title: Sub-100 nm patterning of supported bilayers by nanoshaving lithography.
abstract: Sub-100 nm wide supported phospholipid bilayers (SLBs) were patterned on a planar borosilicate substrate by AFM-based nanoshaving lithography. First, a bovine serum albumin monolayer was coated on the glass and then selectively removed in long strips by an AFM tip. The width of vacant strips could be controlled down to 15 nm. Bilayer lines could be formed within the vacant strips by vesicle fusion. It was found that stable bilayers formed by this method had a lower size limit of approximately 55 nm in width. This size limit stems from a balance between a favorable bilayer adhesion energy and an unfavorable bilayer edge energy.
authors.affiliation: Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77843-3012, USA.
authors.forename: Jinjun
authors.initials: J
authors.lastname: Shi
authors.forename: Jixin
authors.initials: J
authors.lastname: Chen
authors.forename: Paul S
authors.initials: PS
authors.lastname: Cremer
mesh_terms: D001881:Borates / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods; D008856:Microscopy, Fluorescence / Q000379:methods; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001881:Borates; D008051:Lipid Bilayers; D010743:Phospholipids; D017640:Silicates; D012710:Serum Albumin, Bovine