Text-mining assisted regulatory annotation.
BACKGROUND
Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental analyses of regulatory networks and sequences rely heavily on positive control data from prior small-scale experiments, but the vast majority of previously discovered regulatory data remains locked in the biomedical literature.


RESULTS
We develop text-mining strategies to identify relevant publications and extract sequence information to assist the regulatory annotation process. Using a vector space model to identify Medline abstracts from papers likely to have high cis-regulatory content, we demonstrate that document relevance ranking can assist the curation of transcriptional regulatory networks and estimate that, minimally, 30,000 papers harbor unannotated cis-regulatory data. In addition, we show that DNA sequences can be extracted from primary text with high cis-regulatory content and mapped to genome sequences as a means of identifying the location, organism and target gene information that is critical to the cis-regulatory annotation process.


CONCLUSIONS
Our results demonstrate that text-mining technologies can be successfully integrated with genome annotation systems, thereby increasing the availability of annotated cis-regulatory data needed to catalyze advances in the field of gene regulation.
Aerts
Stein
S
Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, B-3000, Belgium. stein.aerts@med.kuleuven.be
Haeussler
Maximilian
M
van Vooren
Steven
S
Griffith
Obi L
OL
Hulpiau
Paco
P
Jones
Steven J M
SJ
Montgomery
Stephen B
SB
Bergman
Casey M
CM
D000818:Animals; D053263:Gene Regulatory Networks; D016678:Genome; D006801:Humans; D016239:MEDLINE; D050436:Regulatory Elements, Transcriptional