Ca(v)1 L-type Ca2+ channel signaling complexes in neurons.
Ca(v)1 L-type Ca2+ channels play crucial and diverse roles in the nervous system. The pre- and post-synaptic functions of Ca(v)1 channels not only depend on their intrinsic biophysical properties but also their dynamic regulation by a host of cellular influences. These include protein kinases and phosphatases, G-protein coupled receptors, scaffolding proteins, and Ca2+-binding proteins. The cytoplasmic domains of the main pore forming alpha(1) subunit of Ca(v)1 offer a number of binding sites for these modulators, permitting fast and localized regulation of Ca2+ entry. Through effects on Ca(v)1 gating, localization, and coupling to effectors, protein modulators are efficiently positioned to adjust Ca(v)1 Ca2+ signals that control neuronal excitability, synaptic plasticity, and gene expression.
Calin-Jageman
Irina
I
Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Lee
Amy
A
D000818:Animals; D001665:Binding Sites / Q000502:physiology; D020746:Calcium Channels, L-Type / Q000737:chemistry / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D009420:Nervous System / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D020746:Calcium Channels, L-Type; C419385:L-type calcium channel alpha(1C)