title: [A case of multi-drug resistant tuberculosis showing psychiatric adverse effect by cycloserine].
abstract: A 45-year-old man with multi-drug resistant tuberculosis were referred to our hospital for treatment. We started chemotherapy with cycloserine (CS), ethionamide (TH), kanamycin (KM), pyrazinamide (PZA), para-aminosalicylic acid (PAS) and gatifloxacin (GFLX). Two months later, psychosis and seizure occurred and worsened day after day. We suspected that these symptoms were due to CS. After stopping CS, psychosis and seizure disappeared. After surgical operation, positive tubercle bacilli in sputum converted to negative both on smear and culture. He was successfully discharged from our hospital. We should take care on side effects with second-line drugs that are often used in treating multi-drug resistant tuberculosis.
authors.affiliation: Department of Respiratory Medicine, Tsukuba Gakuen Hospital, 2573-1, Kamiyokoba, Tsukuba-shi, Ibaraki 305-0854, Japan. jjjjfujita@hotmail.com
authors.forename: Junichi
authors.initials: J
authors.lastname: Fujita
authors.forename: Kouichi
authors.initials: K
authors.lastname: Sunada
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hayashihara
authors.forename: Takefumi
authors.initials: T
authors.lastname: Saito
mesh_terms: D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D003523:Cycloserine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular; D003523:Cycloserine