Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders.
OBJECTIVE
We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders.


METHODS
Genetic association study of quantitative lipoprotein traits.


METHODS
In a sample of 1,310 adult Greenlanders, fasting plasma lipid, lipoprotein and apolipoprotein (apo) concentrations were assessed for association with known functional genomic variants of APOC3, APOA5, APOE and PON1. For significantly associated polymorphisms, between-genotype differences were examined in closer detail.


RESULTS
We found that (1) the APOE restriction isotype was associated with variation in plasma total and LDL cholesterol and apo B (all p < .0001); (2) the APOC3 promoter genotype was associated with variation in plasma triglycerides, HDL cholesterol and apo A-I (all p < .002); (3) the APOA5 codon 19 genotype was associated with variation in plasma triglycerides (p = .027); and (4) the PON1 codon 192 genotype was associated with variation in total and LDL cholesterol and apo B (all p < .05).


CONCLUSIONS
Taken together, our results suggest that common genetic variations in APOC3, APOA5, APOE and PON1 are associated with significant variation in intermediate traits in plasma lipoprotein metabolism in Greenlanders; the associations are similar to those observed for these variants in other populations.
Lahiry
Piya
P
Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada.
Ban
Matthew R
MR
Pollex
Rebecca L
RL
Feldman
Ross D
RD
Sawyez
Cynthia G
CG
Huff
Murray W
MW
Young
T Kue
TK
Bjerregaard
Peter
P
Hegele
Robert A
RA
D000328:Adult; D000367:Age Factors; D053305:Apolipoprotein C-III / Q000235:genetics*; D001054:Apolipoproteins A / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006116:Greenland; D006801:Humans; D004930:Inuit; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D001057:Apolipoproteins E; D008074:Lipoproteins; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human