title: Correlates of local cerebral blood flow (CBF) in normal pressure hydrocephalus patients before and after shunting--A retrospective analysis of [(15)O]H(2)O PET-CBF studies in 65 patients.
abstract: OBJECTIVE
  Findings in local cerebral blood flow (rCBF) in Normal pressure hydrocephalus (NPH) have always been challenged by the variable and inconsistent relation to clinical symptoms before and after shunt treatment. [(15)O]H(2)O PET data from a consecutive cohort of 65 idiopathic NPH patients were retrospectively analyzed questioning whether the functional status before and after shunt treatment might correlate with local blood flow.
  
  
  METHODS
  Using statistical parametric mapping (SPM99, Wellcome Department of Cognitive Neurology, London), the [(15)O]H(2)O uptake was correlated with the preoperative clinical scores, graded according to a modified Stein and Langfitt score. Furthermore, differences in the uptake in the pre-and post-shunt treatment study after seven to 10 days in patients with and without clinical improvement were studied.
  
  
  RESULTS
  A higher clinical score significantly correlated with a reduced tracer uptake in mesial frontal (k=1,239 voxel, Z=4.41) and anterior temporal (k=469, Z=4.07) areas. In the mesial frontal areas, tracer uptake showed significant reciprocal changes in the clinically improved vs. the unimproved patients.
  
  
  CONCLUSIONS
  Matched with the existing literature, the regional blood flow alterations are suggested relevant to the NPH syndrome and to post-treatment functional changes. The present rCBF findings warrant prospective studies on the accuracy of neuroimaging studies as they may provide a more specific insight into disease mechanisms.
authors.affiliation: Department of Neurosurgery, International Neuroscience Institute, Rudolf-Pichlmayr- Str. 4, 30625 Hannover, Germany. pmklinge@gmail.com
authors.forename: Petra M
authors.initials: PM
authors.lastname: Klinge
authors.forename: David J
authors.initials: DJ
authors.lastname: Brooks
authors.forename: Amir
authors.initials: A
authors.lastname: Samii
authors.forename: Eva
authors.initials: E
authors.lastname: Weckesser
authors.forename: Jörg
authors.initials: J
authors.lastname: van den Hoff
authors.forename: Harald
authors.initials: H
authors.lastname: Fricke
authors.forename: Thomas
authors.initials: T
authors.lastname: Brinker
authors.forename: Wolfram H
authors.initials: WH
authors.lastname: Knapp
authors.forename: Georg
authors.initials: G
authors.lastname: Berding
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply*; D015331:Cohort Studies; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000000981:diagnostic imaging* / Q000601:surgery*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010101:Oxygen Consumption / Q000502:physiology; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow / Q000502:physiology; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt
chemical_list: D010104:Oxygen Radioisotopes