title: Risk factors for X-ray pneumonia in the first year of life and its relation to wheezing: a longitudinal study in a socioeconomic disadvantaged population.
abstract: BACKGROUND
  Although thousands of infants under the age of 12 months die each year from pneumonia in Latin America, little is known regarding the true occurrence of pneumonia, wheezing and other related respiratory illnesses in this age group.
  
  
  RESULTS
  In order to describe the prevalence and risk factors for radiologically confirmed pneumonia during the first year of life, a birth-cohort (n = 188) of infants born in a low-income area in Santiago, Chile was followed up monthly.
  
  
  RESULTS
  The prevalence of pneumonia during the first year of life was 13.3 % and there were no fatal events. Exclusive breastfeeding during the first 4 months of life was more prevalent in the non pneumonia group; conversely, wheezing episodes during 0-3 and 3-6 months of age, and hospitalization due to lower respiratory infection during 3-6 and 9-12 months of age were more prevalent in the pneumonia group. After a logistic multivariate analysis, the only risk factor that remained related with pneumonia was wheezing during the first 3 months of life (adjusted OR: 7.7, 95 CI: 1.32-44.92, p = 0.024); while breastfeeding during the first 4 months was an independent protective factor for pneumonia (adjusted OR: 0.11, 95 CI: 0.03-0.44, p = 0.002).
  
  
  CONCLUSIONS
  The significant protective effect of exclusive breast feeding against pneumonia in this cohort and the evident role of recurrent wheezing as risk factor for pneumonia during the first year of life support the implementation or reinforcement of public policies encouraging exclusive breastfeeding and an adequate management of wheezing since the first months of life.
authors.affiliation: School of Medicine, Pontificia Universidad Católica de Chile, Chile. jacastro17@hotmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Castro-Rodriguez
authors.forename: J
authors.initials: J
authors.lastname: Mallol
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez
authors.forename: F
authors.initials: F
authors.lastname: Auger
authors.forename: R
authors.initials: R
authors.lastname: Andrade
mesh_terms: D000886:Anthropometry; D001942:Breast Feeding; D002677:Chile / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006798:Housing / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011014:Pneumonia / Q000150:complications / Q000000981:diagnostic imaging / Q000191:economics / Q000453:epidemiology* / Q000517:prevention & control; D011203:Poverty / Q000706:statistics & numerical data*; D015995:Prevalence; D011859:Radiography; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology*; D012307:Risk Factors; D012494:Sampling Studies; D012959:Socioeconomic Factors