Serum prostate-specific antigen levels in men with type 2 diabetes.
OBJECTIVE
The aims of this study were to examine if serum prostate-specific antigen (PSA) levels are lower in men with type 2 diabetes compared with those in healthy men and to investigate what factors may be associated with serum PSA levels in men with type 2 diabetes.


METHODS
We compared the serum PSA levels in 224 diabetic men with those in 1,293 healthy men and investigated the relationships between serum PSA levels and various variables.


RESULTS
Except for men aged 40-49 years, serum PSA levels were lower in diabetic men than in healthy men. Multiple regression analysis demonstrated that age, BMI, and presence of diabetes were independent determinants of serum PSA level.


CONCLUSIONS
Serum PSA levels were lower in diabetic men compared with those in healthy men, which is in line with previous reports that patients with type 2 diabetes are at a decreased risk of prostate cancer.
Fukui
Michiaki
M
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.com
Tanaka
Muhei
M
Kadono
Mayuko
M
Imai
Saeko
S
Hasegawa
Goji
G
Yoshikawa
Toshikazu
T
Nakamura
Naoto
N
D000328:Adult; D000368:Aged; D000728:Androgens / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D012016:Reference Values
D000728:Androgens; D017430:Prostate-Specific Antigen