title: [Weaning from non-invasive positive pressure ventilation: experience with progressive periods of withdraw].
abstract: BACKGROUND
  In recent years non-invasive ventilation (NIV) as become a valuable therapeutic option in exacerbations of patients with chronic pulmonary obstructive disease. Although widely used there is a paucity of information on weaning from NIV.
  
  
  OBJECTIVE
  We aimed to describe the performance of a weaning protocol based on progressive periods of NIV withdraw.
  
  
  METHODS
  During a one year period we performed NIV in 78 patients with acute exacerbation of chronic respiratory failure. Weaning was considered in patients with 24 hours without acidosis and respiratory rate less than 25 cycles per minute. Weaning was performed as following: during the first 24 hours in each 3 hours, one hour without NIV (except during night period), in the second day in each 3 hours, two hours without NIV (except during night period) and in the third day NIV was used during the night period.
  
  
  RESULTS
  Sixty five patients began the weaning protocol. Mean NIV time was 120,9 hours (17 to 192 hours). No adverse effects were recorded in patients who began the weaning protocol. All patients completed the weaning protocol with no re-institution of NIV or invasive ventilation during hospitalization.
  
  
  CONCLUSIONS
  We report an excellent weaning success rate of NIV in patients with acute severe exacerbation of CRF. Although our weaning protocol required 72 hours, our results suggest that strategies based on periods with and with-out NIV are effective. Weather similar less time consuming weaning strategies are effective, merits investigation.
authors.affiliation: Servico de Pneumologia, Hospital S. Joao, Alameda Hernani Monteiro, Porto, Portugal. cdamas@aeiou.pt
authors.forename: C
authors.initials: C
authors.lastname: Damas
authors.forename: C
authors.initials: C
authors.lastname: Andrade
authors.forename: J P
authors.initials: JP
authors.lastname: Araújo
authors.forename: J
authors.initials: J
authors.lastname: Almeida
authors.forename: P
authors.initials: P
authors.lastname: Bettencourt
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000628:therapy*; D013997:Time Factors; D015300:Ventilator Weaning / Q000379:methods*