title: Isolated non-Hodgkin's lymphoma of the pancreas: case report and review of literature.
abstract: BACKGROUND
  Isolated primary pancreatic lymphoma (PPL) is a rare extra-lymphatic non-Hodgkin's lymphoma comprising less than 1% of all extra-lymphatic lymphomas. It is seen in people of advanced age and there is a slight male preponderance. It is difficult to diagnose; the vague presenting symptoms and nonspecific laboratory/radiological findings make it difficult to differentiate the condition from pancreatic adenocarcinoma. Histopathological examination is of paramount importance to conclusively establish the diagnosis since the treatment involves lymphoma protocols, and prognosis and survival in PPL are considerably superior to that in adenocarcinoma pancreas.
  
  
  METHODS
  We report a case of isolated PPL diagnosed after Tru-Cut biopsy and immunohistochemistry after a thorough staging workup.
  
  
  RESULTS
  The patient was treated with multi-agent combination chemotherapy followed by radiotherapy.
  
  
  CONCLUSIONS
  A review of literature was done using a Medline search to determine the incidence and prevalence of isolated PPL and to note the diagnosis and management of previously reported cases.
  
  
  CONCLUSIONS
  An exceedingly rare entity, isolated PPLs need to be differentiated from pancreatic adenocarcinomas by histopathological evaluation since management is on the lines of other extralymphatic lymphomas and prognosis is significantly better.
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai - 400 012, Maharashtra, India.
authors.forename: Ayan
authors.initials: A
authors.lastname: Basu
authors.forename: Nikhilesh
authors.initials: N
authors.lastname: Patil
authors.forename: Pranshu
authors.initials: P
authors.lastname: Mohindra
authors.forename: Bhooshan
authors.initials: B
authors.lastname: Zade
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gujral
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Muckaden
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Laskar
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D011379:Prognosis; D016896:Treatment Outcome