title: Does preoperative hydration affect postoperative nausea and vomiting? A randomized, controlled trial.
abstract: BACKGROUND
  It has been suggested that relative hypovolemia due to overnight fasting may result in postoperative nausea and vomiting (PONV). The aim of this study was to investigate the effect of preoperative and intraoperative hydration (the necessary amount of fluid preoperatively to cover the fluid deficit) on PONV.
  
  
  METHODS
  Two hundred and ten consecutive patients who underwent elective laparoscopic cholecystectomy with The American Society of Anesthesiologists (ASA)-I physical statuses were studied prospectively. The patients were randomly assigned to one of two groups, each having 104 patients. Group 1 received intraoperative volume replacement, but Group-II received preoperative volume replacement. Postoperative antiemetic efficacy was assessed by the ratio of the patients that require an antiemetic over the whole group.
  
  
  RESULTS
  The PONV was significantly less detected in the preoperative replacement group (48% in Group 2) than the intraoperative one (64% in Group 1) (P = 0.019).
  
  
  CONCLUSIONS
  PONV was reduced when the fluid deficit was replaced preoperatively.
authors.affiliation: Department of Anesthesiology, Ataturk Training and Research Hospital, Izmir, Turkey. tadanir@tnn.net
authors.forename: Tayfun
authors.initials: T
authors.lastname: Adanir
authors.forename: Murat
authors.initials: M
authors.lastname: Aksun
authors.forename: Uğur
authors.initials: U
authors.lastname: Ozgürbüz
authors.forename: Fahri
authors.initials: F
authors.lastname: Altin
authors.forename: Atilla
authors.initials: A
authors.lastname: Sencan
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use; D017081:Cholecystectomy, Laparoscopic; D017558:Elective Surgical Procedures; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D020896:Hypovolemia / Q000517:prevention & control; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics