[Kawasaki disease and atherosclerosis].
The existence of endothelial damage in impaired coronary arteries, both aneurysms and regressed aneurysms, even during the chronic stage of Kawasaki disease (KD) has been reported by morphologic and functional studies. In addition, based on our results of endothelial-dependent dilatation in systemic arteries or the pathological findings in weaning rabbits in the chronic stage of KD-like allergic coronary arteritis by administering a hypercholesterol diet, it is suggested that vascular endothelial dysfunction, not only in coronary arteries but also in systemic arteries, could exist in the KD patients even in a chronic stage, and also suggested that a history of KD was possible to be one of the risk factor for the early onset of atherosclerosis.
Niboshi
Ayumi
A
Department of Paediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science.
Ozawa
Seiichiro
S
Hamaoka
Kenji
K
D000818:Animals; D001167:Arteritis / Q000209:etiology; D050197:Atherosclerosis / Q000209:etiology*; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000209:etiology; D006801:Humans; D007223:Infant; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D011817:Rabbits