title: Bioactive polymeric materials for targeted administration of active agents: synthesis and evaluation.
abstract: Bioerodible polymers displaying both stealth and targeting properties for the preparation of nanosystems for targeted and controlled delivery of fibrinolytic drugs to the thrombus were prepared by straightforward synthetic routes and characterized. Poly[(maleic anhydride)-alt-(butylvinyl ether)]s were synthesized in the presence of dodecyl mercaptan as chain transfer agent allowing for the preparation of copolymers with tunable molecular weight. 2-Methoxyethanol hemiesters containing antiopsonizing molecules of poly(ethylene glycol) were prepared and further biofunctionalized with a Fab fragment by a two-step reaction. In vitro biocompatibility investigation of the prepared materials supported their suitability for biomedical applications.
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications, Department of Chemistry & Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56122 San Piero a Grado, Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Chiellini
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Piras
authors.forename: Matteo
authors.initials: M
authors.lastname: Gazzarri
authors.forename: Cristina
authors.initials: C
authors.lastname: Bartoli
authors.forename: Marcella
authors.initials: M
authors.lastname: Ferri
authors.forename: Laura
authors.initials: L
authors.lastname: Paolini
authors.forename: Emo
authors.initials: E
authors.lastname: Chiellini
mesh_terms: D000818:Animals; D041702:BALB 3T3 Cells; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems / Q000379:methods*; D004951:Esterification; D004987:Ethers / Q000737:chemistry; D005337:Fibrin / Q000737:chemistry / Q000276:immunology; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000737:chemistry; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry / Q000276:immunology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008299:Maleic Anhydrides / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004987:Ethers; D005343:Fibrinolytic Agents; D007140:Immunoglobulin Fab Fragments; D008299:Maleic Anhydrides; D011108:Polymers; D013438:Sulfhydryl Compounds; D014753:Vinyl Compounds; C521980:butyl vinyl ether; C013976:dodecylmercaptan; C016683:polymaleic anhydride; D011092:Polyethylene Glycols; D005337:Fibrin