title: The cerebrovascular pathology in Alzheimer's disease and its influence on clinical variables.
abstract: Vascular pathology is frequently found in the brains of patients with Alzheimer's disease (AD). The aim of this study is to assess the frequency of vascular pathology in the brain in AD patients in a systematic manner and its clinical significance at presentation. A series of 51 patients with mild to moderate AD were consecutively enrolled. At baseline, every patient underwent the following clinical scales: Mini-Mental, Clinical Dementia Rating Scale, Ischemic Scale, Blessed Dementia Rating Scale, Alzheimer's Disease Assessment Scale Cognitive Subscale, Neuropsychiatric Inventory, and an Activities of Daily Living Scale (Disability Assessment for Dementia). We also carried out magnetic resonance imaging of the brain and color echo Doppler of carotids to measure the intima-media thickness. White matter hyperintensities were quantitatively evaluated with the Wahlund scale. We did not find correlation between intima-media thicknesses of carotids and clinical scales and between the Wahlund scale and clinical scales. The presence or absence of both microinfarctions and hypertension had no influence in the scores of the clinical scales. We conclude that the vascular component is common in AD but only as coincident pathology.
authors.affiliation: Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain. pmodrego@salud.aragon.es
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Modrego
authors.forename: Consuelo
authors.initials: C
authors.lastname: Rios
authors.forename: José M
authors.initials: JM
authors.lastname: Pérez Trullen
authors.forename: José M
authors.initials: JM
authors.lastname: Errea
authors.forename: Maria J
authors.initials: MJ
authors.lastname: García-Gómara
authors.forename: Sara
authors.initials: S
authors.lastname: Sanchez
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015140:Dementia, Vascular / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D015995:Prevalence; D012720:Severity of Illness Index