title: Anti-inflammatory and anthelmintic activities of Solanum khasianum Clarke.
abstract: In order to scientifically appraise some of the folkloric uses of Solanum khasianum Clarke (Solanaceae), the present study was undertaken to examine the anti-inflammatory and anthelmintic properties of the berries of ethanol extract. Anti-inflammatory activity was tested in carrageenan induced rat hind paw edema method at three dose level of 200, 300, and 400 mg kg(-1) respectively, Diclofenac sodium (100 mg kg(-1)) was used as the reference standard. The anti-inflammatory activity of the extract was compared with standard and control. The anthelmintic activity of the extract was tested on tape worm, liver fluke, thread worm, and hook worm using two different concentrations, 100 and 200 mg mL(-1) respectively. Time taken for the inhibition of motility was noted and compared with the standard drug, Piperazine citrate 15 mg mL. The plant extract significantly (p < 0.01) reduced the inflammation of the rats when compared to the control group. Also, the ethanol extract of the plant paralyzed the worms followed by death, which was comparable with that of the standard. This study supports the folk claim.
authors.affiliation: Department of Pharmacognosy, BR Nahata College Pharmacy-SIRO, Mandsaur-458001, Madhya Pradesh, India. ejeru@rediffmail.com
authors.forename: E Edwin
authors.initials: EE
authors.lastname: Jarald
authors.forename: S
authors.initials: S
authors.lastname: Edwin
authors.forename: V
authors.initials: V
authors.lastname: Saini
authors.forename: L
authors.initials: L
authors.lastname: Deb
authors.forename: V B
authors.initials: VB
authors.lastname: Gupta
authors.forename: S P
authors.initials: SP
authors.lastname: Wate
authors.forename: K P
authors.initials: KP
authors.lastname: Busari
mesh_terms: D000871:Anthelmintics / Q000737:chemistry / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*
chemical_list: D000871:Anthelmintics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts