[Oxidative stress in the neonatal lung disease].
Oxidative stress is a risk factor for bronchopulmonary dysplasia in the preterm newborn. Antioxidant defense is impaired in the preterm newborn. Oxidative stress is also involved in cell growth and development. The relationship between oxidative stress and cell growth needs to be understood before antioxidant therapy can be routinely introduced. Several antioxidant therapies have been unsuccessfully tried until now. This review highlights the importance of oxygen free radicals in the pathogenesis of bronchopulmonary dysplasia.
Rocha
Gustavo
G
Serviço de Neonatologia. Unidade Autónoma de Gestão da Mulher e da Criança, Hospital de São João, Porto, Portugal. gusrocha@oninet.pt
D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008670:Metals / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D008670:Metals; D017382:Reactive Oxygen Species; D009569:Nitric Oxide