title: Assessment of the phototoxic potential of cosmetic products.
abstract: The cosmetics are nontoxic or less toxic in perse but photoactivation may then sensitize and could produce additional phototoxicity. Phototoxicity assessment of ten different lipsticks and eight facial creams was conducted. Results revealed that six lipsticks and five facial creams generated reactive oxygen species (ROS), produced haemolysis and caused lipid peroxidation in human erythrocytes (in vitro) under sunlight exposure. Seven creams and one lipstick were alkaline while one cream and two lipsticks were acidic. The test lipsticks and creams showed absorption in UV/visible range. The study demonstrated synergistic action of cosmetic products and sunlight. Therefore, sunlight exposure should be avoided after the use of photosensitive cosmetics.
authors.affiliation: Photobiology Division, Industrial Toxicology Research Centre, MG Marg, Lucknow, UP, India. rkhans2004@rediffmail.com
authors.forename: Rajendra K
authors.initials: RK
authors.lastname: Hans
authors.forename: Neeraj
authors.initials: N
authors.lastname: Agrawal
authors.forename: Kiran
authors.initials: K
authors.lastname: Verma
authors.forename: Rajendra B
authors.initials: RB
authors.lastname: Misra
authors.forename: Ratan S
authors.initials: RS
authors.lastname: Ray
authors.forename: Mohammad
authors.initials: M
authors.lastname: Farooq
mesh_terms: D003358:Cosmetics / Q000633:toxicity*; D017484:Dermatitis, Phototoxic / Q000473:pathology*; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000032:analysis; D013472:Sunlight; D013481:Superoxides / Q000032:analysis; D014466:Ultraviolet Rays
chemical_list: D003358:Cosmetics; D007202:Indicators and Reagents; D017382:Reactive Oxygen Species; D013481:Superoxides