Functional topography of early periventricular brain lesions in relation to cytoarchitectonic probabilistic maps.
Early periventricular brain lesions can not only cause cerebral palsy, but can also induce a reorganization of language. Here, we asked whether these different functional consequences can be attributed to topographically distinct portions of the periventricular white matter damage. Eight patients with pre- and perinatally acquired left-sided periventricular brain lesions underwent focal transcranial magnetic stimulation to assess the integrity of cortico-spinal hand motor projections, and functional MRI to determine the hemispheric organization of language production. MRI lesion-symptom mapping revealed that two distinct portions of the periventricular lesions were critically involved in the disruption of cortico-spinal hand motor projections on the one hand and in the induction of language reorganization into the contra-lesional right hemisphere on the other hand. Both regions are located in a position compatible with the course of cortico-spinal/cortico-nuclear projections of the primary motor cortex in the periventricular white matter, as determined by the stereotaxic probabilistic cytoarchitectonic atlas developed by the Jülich group.
Staudt
Martin
M
Department of Pediatric Neurology and Developmental Medicine, University Children's Hospital, Hoppe-Seyler-Str. 1, D-72076 Tübingen, Germany. martin.staudt@med.uni-tuebingen.de
Ticini
Luca F
LF
Grodd
Wolfgang
W
Krägeloh-Mann
Ingeborg
I
Karnath
Hans-Otto
HO
D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006429:Hemiplegia / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D011712:Pyramidal Tracts / Q000473:pathology / Q000503:physiopathology; D013060:Speech / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods