Biologically active metabolites from the basidiomycete Limacella illinita (Fr.) Murr.
In the course of our search for new bioactive compounds from basidiomycetes, four new compounds were isolated from fermentations of Limacella illinita. Illinitone A (1) exhibited weak phytotoxic and moderate nematicidal activities against Caenorhabditis elegans, illinitone B (2) was moderately cytotoxic, while limacellone (3) exhibited weak cytotoxic and phytotoxic activities. The muurolane sesquiterpene 4a was found to be inactive in the assays performed here. Limacellone (3), which appeared to be related with the illinitones 1 and 2, has a new C15 carbon skeleton. It is possible that compounds 1, 2 and 3 are terpenoids/ secoterpenoids, but their biosyntheses were not investigated.
Gruhn
Nina
N
Department of Biotechnology, University of Kaiserslautern, Germany.
Schoettler
Sylvia
S
Sterner
Olov
O
Anke
Timm
T
D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry* / Q000254:growth & development; D017173:Caenorhabditis elegans / Q000187:drug effects; D002457:Cell Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D000969:Antinematodal Agents; D002457:Cell Extracts