Carboxylesterase 2 is downregulated in colorectal cancer following progression of the disease.
Expression of carboxylesterase 2 in colorectal tumor tissues and serum carboxylesterase 2 levels at different stages of the disease were investigated by Western blotting. Carboxylesterase 2 was decreasing in tumor tissues from TNM stages 0 through IV (n = 20); the expression of carboxylesterase 2 was similar between "normal" and tumor tissues (n = 20); serum carboxylesterase 2 levels were similar among patients at different stages of the disease. These results indicate that local expression of carboxylesterase 2 is downregulated following progression of the disease; carboxylesterase 2 expression is altered in histology "normal" tissues from stages I through IV before histopathological changes.
Tang
Xiaobo
X
College of Pharmacy, Harbin Medical University, Harbin, China.
Wu
Hong
H
Wu
Zhenghua
Z
Wang
Guiyu
G
Wang
Zhigang
Z
Zhu
Daling
D
D000230:Adenocarcinoma / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D002166:Camptothecin / Q000031:analogs & derivatives / Q000627:therapeutic use; D043182:Carboxylesterase / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D018450:Disease Progression; D015536:Down-Regulation; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D000077146:Irinotecan; D051379:Mice; D009367:Neoplasm Staging; D059004:Topoisomerase I Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D059004:Topoisomerase I Inhibitors; D000077146:Irinotecan; C517204:CES2 protein, human; D043182:Carboxylesterase; D002166:Camptothecin