Isolation of 8'-phosphate ester derivatives of amicoumacins: structure-activity relationship of hydroxy amino acid moiety.
Two new compounds, 8'-phospho derivatives of amicoumacins A and B, were isolated from the culture broth of a strain of Bacillus pumilus together with amicoumacins A and B. Their structures were elucidated on the basis of spectroscopic methods and alkaline phosphatase treatments. Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8' hydroxyl and C-12' amide group of amicoumacin A played a critical role for anti-MRSA activity.
Hashimoto
Makoto
M
Reseach Institute of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishitokyo, Tokyo, Japan.
Taguchi
Takaaki
T
Nishida
Satoshi
S
Ueno
Kouji
K
Koizumi
Kaio
K
Aburada
Masaki
M
Ichinose
Koji
K
D000469:Alkaline Phosphatase / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D003374:Coumarins; C031379:amicoumacin A; D000469:Alkaline Phosphatase