title: Decoding the dynamics of T cell-dendritic cell interactions in vivo.
abstract: T lymphocytes receive activation signals during their encounters with antigen-bearing dendritic cells (DCs) in secondary lymphoid organs. With the recent application of two-photon imaging to visualize immune responses as they happen, the dynamics of T cell-DC interactions have been dissected in several mouse models. As we are integrating the results of these new studies, we are learning that the dynamics of T cell-DC interactions are regulated by multiple immunological parameters and, most importantly, that the spatiotemporal characteristics of these cell-cell contacts encode part of the T-cell fate.
authors.affiliation: G5 Dynamiques des Réponses Immunes, Département d'Immunologie, Institut Pasteur, Paris, France.
authors.forename: Susanna
authors.initials: S
authors.lastname: Celli
authors.forename: Zacarias
authors.initials: Z
authors.lastname: Garcia
authors.forename: Hélène
authors.initials: H
authors.lastname: Beuneu
authors.forename: Philippe
authors.initials: P
authors.lastname: Bousso
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens; D002450:Cell Communication / Q000276:immunology / Q000502:physiology*; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
chemical_list: D000941:Antigens