title: Vertical transmission of multidrug-resistant Q151M human immunodeficiency virus type 1 strains.
abstract: We report the first case of mother-to-child transmission of human immunodeficiency virus type 1 strains harboring multiple mutations including the Q151M multinucleoside reverse transcriptase inhibitor resistance mutation. Sustained virologic success was obtained in the infant with postnatal antiretroviral therapy optimized according to genotypic drug resistance testing and therapeutic drug monitoring.
authors.affiliation: Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique et d'Hygiène, CHRU Timone, Marseille, France.
authors.forename: Mireille
authors.initials: M
authors.lastname: Henry
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thuret
authors.forename: Caroline
authors.initials: C
authors.lastname: Solas
authors.forename: Sèverine
authors.initials: S
authors.lastname: Genot
authors.forename: Philippe
authors.initials: P
authors.lastname: Colson
authors.forename: Catherine
authors.initials: C
authors.lastname: Tamalet
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy
chemical_list: D044966:Anti-Retroviral Agents