title: Facile and convenient method of deuterium gas generation using a Pd/C-catalyzed H2-D2 exchange reaction and its application to synthesis of deuterium-labeled compounds.
abstract: The Pd/C-catalyzed H(2)-D(2) exchange reaction using a H(2)-D(2)O combination provided a general, efficient and environmentally friendly route for the preparation of deuterium gas (D(2)). H(2) sealed in a reaction flask was converted into nearly pure D(2), which could be used for the Pd/C-catalyzed one-pot reductive deuteration of various reducible functionalities and the chemoselective one-pot deuterogenation of olefin and acetylene. Additionally, we established the capturing method of the generated D(2) in a balloon, which was successfully applied to the Pd/C-catalyzed reductive mono-N-alkylation of a primary amine using nitrile as the alkylating reagent.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi 5-6-1, Gifu, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Kurita
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Aoki
authors.forename: Takuto
authors.initials: T
authors.lastname: Mizumoto
authors.forename: Toshihide
authors.initials: T
authors.lastname: Maejima
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Esaki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D002244:Carbon / Q000737:chemistry*; D003903:Deuterium / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D010165:Palladium; D002244:Carbon; D006859:Hydrogen; D003903:Deuterium