title: Synthesis of cyclic thioethers through tandem C(sp3)-S and C(sp2)-S bond formations from alpha,beta'-dichloro vinyl ketones.
abstract: The synthesis of 5- to 8-memebered cyclic thioethers 4 has been achieved through a simple two-step sequence. The present methodology utilizes the facile Friedel-Crafts acylation of terminal alkynes 1 with acid chlorides 2 followed by tandem C(sp(3))-S and C(sp(2))-S bond formations with NaSH.xH(2)O.
authors.affiliation: Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA. oh@chem.iupui.edu
authors.forename: Kyungsoo
authors.initials: K
authors.lastname: Oh
authors.forename: Hyunjung
authors.initials: H
authors.lastname: Kim
authors.forename: Francesco
authors.initials: F
authors.lastname: Cardelli
authors.forename: Tamayi
authors.initials: T
authors.lastname: Bwititi
authors.forename: Anna M
authors.initials: AM
authors.lastname: Martynow