title: [Relationship between GATA-3 and IL-12 in patients with allergic rhinitis].
abstract: OBJECTIVE
  To explore the relationship between GATA-3 and IL-12 in patients with allergic rhinitis.
  
  
  METHODS
  The expression of GATA-3 was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in 37 patients with allergic rhinitis and 12 control samples. IL-12 was detected by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The relative density ratio of GATA-3 to GAPDH in AR patients was 0.579 +/- 0.102, and in control group was 0.128 +/- 0.021. The concentrations of IL-12 were (53.7 +/- 12.3) ng/g and (121.9 +/- 20.4) ng/g in the two groups respectively. The expression of GATA-3 was negatively correlated to the expression of IL-12 in patients with allergic rhinitis.
  
  
  CONCLUSIONS
  The overexpression of GATA-3 in patients with allergic rhinitis was related to the decrease of IL-12, and to increasing the expression of IL-12 in topical tissue could suppress the expression of GATA-3 and may improve the therapeutic effectiveness of AR.
authors.affiliation: Department of Otolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. Christyhui@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Mei
authors.initials: M
authors.lastname: Xu
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*
chemical_list: D050990:GATA3 Transcription Factor; D018664:Interleukin-12