title: Fasting insulin pulsatile secretion in lean women with polycystic ovary syndrome.
abstract: The aim of our study was to evaluate rapid insulin pulses and insulin secretion regularity in fasting state in lean women with polycystic ovary syndrome (PCOS) in comparison to lean healthy women. PCOS (n=8) and controls (n=7) underwent every minute blood sampling for 60 min. Insulin pulsatility was assessed by deconvolution and insulin secretion regularity by approximate entropy methodology. PCOS had higher testosterone (p<0.02), prolactin (p<0.05) and lower sex hormone binding globulin (SHBG) (p<0.0006) levels than controls. Approximate entropy, insulin pulse frequency, mass, amplitude and interpulse interval did not differ between PCOS and controls. PCOS had broader insulin peaks determined by a common half-duration (p<0.07). Burst mass correlated positively with testosterone (p<0.05) and negatively with SHBG (p 0.0004) and common half-duration correlated positively with prolactin (p<0.008) and cortisol levels (p<0.03). Approximate entropy positively correlated with BMI (p<0.04) and prolactin (p<0.03). Lean PCOS patients tended to have broader insulin peaks in comparison to healthy controls. Prolactin, androgens and cortisol might participate in alteration of insulin secretion in PCOS-affected women. Body weight and prolactin levels could influence insulin secretion regularity.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic. tgrimmichova@endo.cz
authors.forename: T
authors.initials: T
authors.lastname: Grimmichová
authors.forename: J
authors.initials: J
authors.lastname: Vrbíková
authors.forename: P
authors.initials: P
authors.lastname: Matucha
authors.forename: K
authors.initials: K
authors.lastname: Vondra
authors.forename: P P
authors.initials: PP
authors.lastname: Veldhuis
authors.forename: M L
authors.initials: ML
authors.lastname: Johnson
mesh_terms: D000328:Adult; D001835:Body Weight / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005215:Fasting; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood* / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D011673:Pulsatile Flow; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D011388:Prolactin; D006854:Hydrocortisone