Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis.
OBJECTIVE
To determine serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up.


METHODS
This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17).


RESULTS
At the time of diagnosis, serum IL-1beta, IL-6, IL-8, and TNF-alpha levels of culture-proven sepsis were significantly higher than those of the control groups (P<.05). At the time of diagnosis, IL-1beta, IL-6, IL-8, and TNF-alpha levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment.


CONCLUSIONS
Serum IL-1beta, IL-6, IL-8, and TNF-alpha are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.
Kurt
A Nese Citak
AN
Department of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, Turkey. nkurt@firat.edu.tr
Aygun
A Denizmen
AD
Godekmerdan
Ahmet
A
Kurt
Abdullah
A
Dogan
Yasar
Y
Yilmaz
Erdal
E
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology; D002633:Chemotaxis; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha