title: Coupled mother-child model for bioaccumulation of POPs in nursing infants.
abstract: Bioaccumulation of persistent organic pollutants (POPs) leads to high levels in human milk and high doses of POPs for nursing infants. This is currently not considered in chemical risk assessment. A coupled model for bioaccumulation of organic chemicals in breast-feeding mother and nursing infant was developed and tested for a series of organic compounds. The bioaccumulation factors (BAFs) in mother, breast milk and child were predicted to vary with logK(OW) and, for volatile compounds, with K(AW) and concentration in air. The concentrations of POPs in the infant body increase the first half year to about factor 3 above mother and decline thereafter to lower levels. The predicted results are close to empirical data and to an empirical regression. The new mother-child model is compact due to its easy structure and the analytical matrix solution. It could be added to existing exposure and risk assessment systems, such as EUSES.
authors.affiliation: Technical University of Denmark, Department of Environmental Engineering, Bygningstorvet 115, DK-2800 Kongens Lyngby, Denmark. stt@env.dtu.dk
authors.forename: Stefan
authors.initials: S
authors.lastname: Trapp
authors.forename: Li Ma
authors.initials: LM
authors.lastname: Bomholtz
authors.forename: Charlotte N
authors.initials: CN
authors.lastname: Legind
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D001942:Breast Feeding; D004785:Environmental Pollutants / Q000493:pharmacokinetics*; D005506:Food Contamination; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019570:Inhalation Exposure; D007774:Lactation / Q000502:physiology; D008895:Milk, Human / Q000737:chemistry*; D008954:Models, Biological; D009930:Organic Chemicals / Q000493:pharmacokinetics*; D000072317:Polychlorinated Dibenzodioxins / Q000493:pharmacokinetics
chemical_list: D004785:Environmental Pollutants; D009930:Organic Chemicals; D000072317:Polychlorinated Dibenzodioxins