Phytochemical investigation of Tiarella polyphylla.
Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3beta-hydroxy-20(29)lupen-27-oic acid (9), beta-sitosterol-3-O-beta-D-glucoside (10), stigmasterol-3-O-beta-D-glucoside (11), beta-sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis.
Shen
Guanghai
G
College of Pharmacy, Yanbian University, Yanji 133000, PR China.
Oh
Sei-Ryang
SR
Min
Byung-Sun
BS
Lee
Joongku
J
Ahn
Kyung Seop
KS
Kim
Young Ho
YH
Lee
Hyeong-Kyu
HK
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D051056:Complement Inactivating Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003171:Complement Pathway, Classical / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031995:Saxifragaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D051056:Complement Inactivating Agents; D005419:Flavonoids; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes