title: Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women.
abstract: Mitochondria play important roles in cellular energy production, free radical generation, and apoptosis. In a previous report, the mitochondrial DNA (mtDNA) G10398A (Thr-->Ala) polymorphism was associated with breast cancer risk in African-American women [Cancer Res 2005;65:8028-33]. We sought to replicate the association by genotyping the G10398A polymorphism in multiple established population-based case-control studies of breast cancer in African-American women. The 10398A allele was not significantly associated with risk in any of the studies: San Francisco (542 cases, 282 controls, odds ratio OR = 1.73, 95% confidence interval CI = 0.87-3.47, P = 0.12); Multiethnic Cohort (391 cases, 460 controls, OR = 1.08, 95% CI = 0.62-1.86, P = 0.79); and CARE and LIFE (524 cases, 236 controls, OR = 0.81, 95% CI = 0.43-1.52, P = 0.50). With data pooled across the studies (1,456 cases and 978 controls), no significant association was observed with the 10398A allele (OR = 1.14, 95% CI = 0.80-1.62, P = 0.47, test for heterogeneity = 0.30). In analysis of advanced breast cancer cases (n = 674), there was also no significant association (OR = 1.18, 95% CI = 0.76-1.82, P = 0.46). Our results do not support the hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
authors.forename: Veronica Wendy
authors.initials: VW
authors.lastname: Setiawan
authors.forename: Li-Hao
authors.initials: LH
authors.lastname: Chu
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.forename: Yuan Chun
authors.initials: YC
authors.lastname: Ding
authors.forename: Sue A
authors.initials: SA
authors.lastname: Ingles
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Michael F
authors.initials: MF
authors.lastname: Press
authors.forename: Giske
authors.initials: G
authors.lastname: Ursin
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: Susan L
authors.initials: SL
authors.lastname: Neuhausen
mesh_terms: D044383:Black People / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D015141:Los Angeles; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D018401:Sample Size; D012495:San Francisco; D001741:Black or African American
chemical_list: D004272:DNA, Mitochondrial