title: Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor.
abstract: Solitary fibrous tumor is a mesenchymal tumor that was initially described as a pleural-based lesion, but later was discovered in many other locations. The light-microscopic appearance of solitary fibrous tumor may overlap with other diagnostic entities; however, consistent tumor cell CD34 immunoreactivity is useful in establishing the diagnosis. Limited data suggest that solitary fibrous tumors are karyotypically diverse, and no common or characteristic anomaly has yet emerged for this entity. Cytogenetic analysis of two solitary fibrous tumors, one peritoneal and the other arising in the liver, revealed predominantly structural abnormalities in the former and numerical imbalances in the latter. Clonal karyotypic abnormalities were lacking in three additional solitary fibrous tumors.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-3135, USA.
authors.forename: Alireza
authors.initials: A
authors.lastname: Torabi
authors.forename: Subodh M
authors.initials: SM
authors.lastname: Lele
authors.forename: Dominick
authors.initials: D
authors.lastname: DiMaio
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Pinnt
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Hess
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D002648:Child; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D054364:Solitary Fibrous Tumors / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34