Ultrasound in the (premotor) diagnosis of Parkinson's disease.
A number of independent studies provide evidence that transcranial sonography (TCS) is helpful in the diagnosis of idiopathic and monogenetic Parkinson's disease (PD). In the clinical setting, it may exclude a number of secondary or atypical parkinsonian syndromes at very early stages. TCS may additionally depict morphological alterations of symptoms associated with PD motor features like midline alterations in PD-associated depression. Importantly, substantia nigra (SN) hyperechogenicity, the typical ultrasound marker of PD, can also be found in approximately 9% of healthy subjects. PET studies and conditions challenging the dopaminergic system indicate that this stable ultrasound feature has a functional relevance. Ongoing longitudinal studies test the hypothesis that SN hyperechogenicity is a risk marker for nigrostriatal vulnerability.
Berg
Daniela
D
Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tübingen, Germany. daniela.berg@uni-tuebingen.de
D001921:Brain / Q000473:pathology*; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis*; D017585:Ultrasonography, Doppler, Transcranial