Mitochondrion and its related disorders: making a comeback.
The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.
Zhang
Xian-ning
XN
Zhejiang University-Adinovo Center for Genetic and Genomic Medicine, Zhejiang University, Hangzhou 310058, China. zhangxianning@zju.edu.cn
Qi
Ming
M
D004272:DNA, Mitochondrial / Q000378:metabolism*; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000473:pathology*; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D010085:Oxidative Phosphorylation; D010100:Oxygen; D010641:Phenotype; D017382:Reactive Oxygen Species
D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species; D010100:Oxygen