Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine.
Molecularly imprinted polymer (MIP) monoliths for (+)-nilvadipine have been prepared using 4-vinylpyridine as a functional monomer and toluene/1-dodecanol as a porogen without or with addition of N-carbobenzyloxy-L-tryptophan (Cbz-L-Trp) as a co-template molecule. The MIP monoliths prepared with (+)-nilvadipine as a sole template molecule had no macro through-pores, while those could be formed by addition of Cbz-L-Trp as the co-template molecule. Furthermore, on the former nilvadipine enantiomers could not be separated, but on the latter they could. The presence of Cbz-L-Trp affected the polymerization process and resulted in forming macro through-pores of the MIP monoliths for (+)-nilvadipine and attaining separation of nilvadipine enantiomers. These results suggest that co-addition of Cbz-L-Trp could be effective for preparing MIP monoliths for (+)-nilvadipine, whose preparation is difficult.
Haginaka
Jun
J
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya, Hyogo, Japan. haginaka@mukogawa-u.ac.jp
Futagami
Aya
A
D002846:Chromatography, Affinity; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D011108:Polymers; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry
D011108:Polymers; C035100:nilvadipine; D014364:Tryptophan; D009543:Nifedipine