title: Delivering silence: advancements in developing siRNA therapeutics.
abstract: The number of small interfering RNA (siRNA)-based therapeutics that are in or nearing human clinical trials is rapidly expanding. This review summarizes recent in vivo data obtained from studies on siRNA therapeutics and gives an overview of the key in vivo delivery technologies in use today. A section is also devoted to currently ongoing clinical trials employing siRNA drugs.
authors.affiliation: Alnylam Pharmaceuticals Inc, 300 Third Street, Cambridge, MA 02142, USA. tnovobrantseva@alnylam.com
authors.forename: Tatiana I
authors.initials: TI
authors.lastname: Novobrantseva
authors.forename: Akin
authors.initials: A
authors.lastname: Akinc
authors.forename: Anna
authors.initials: A
authors.lastname: Borodovsky
authors.forename: Antonin
authors.initials: A
authors.lastname: de Fougerolles
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004337:Drug Carriers; D016503:Drug Delivery Systems; D018274:Electroporation; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D011108:Polymers; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D011108:Polymers; D034741:RNA, Small Interfering