Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris.
OBJECTIVE
To investigate the relationship between serum resistin level and acute coronary syndrome (ACS) or stable angina pectoris (SAP).


METHODS
Sixty-five patients, with coronary artery disease, were enrolled and divided into three subgroups: acute myocardial infarction (AMI), unstable angina pectoris (UAP) and SAP, and 26 healthy people were recruited as controls in the cross-sectional study. Serum resistin levels were determined by ELISA (enzyme-linked immunosorbent assay), and WBC (white blood cell count), hsCRP (high sensitive C-reaction protein), CK(max) (maximum of creatinkinase), CK-MB(max) (maximum of isozyme of creatinkinase) and cTnI(max) (maximum of troponin) were measured by standard laboratory methods.


RESULTS
The serum resistin levels were 4 folds higher in AMI patients, 2.43 folds in UAP patients and 1.12 folds in SAP patients than in the healthy controls (P<0.05). The resistin levels were also significantly different between AMI [(8.16+/-0.79) ng/ml], UAP [(5.59+/-0.75) ng/ml] and SAP [(3.45+/-0.56) ng/ml] groups (P<0.01); WBC, hsCRP, CK(max), CK-MB(max) and cTnI(max) were significantly increased in AMI patients over UAP and SAP patients. Spearman analysis showed that serum resistin levels were positively correlated with WBC (r=0.412, P=0.046), hsCRP (r=0.427, P=0.037), CK(max), CK-MB(max) and cTnI(max) (r=0.731, 0.678, 0.656; P<0.01).


CONCLUSIONS
Serum resistin levels increased with inflammatory factors and myocardial impairment. The results suggest that human resistin might play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor.
Qiao
Xiao-zhi
XZ
Department of Very Important Person, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. qxz1971@hzcnc.com
Yang
Yun-mei
YM
Xu
Zhe-rong
ZR
Yang
Li-ai
LA
D054058:Acute Coronary Syndrome / Q000097:blood*; D000787:Angina Pectoris / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D052243:Resistin / Q000097:blood*
D052243:Resistin