Standardized T2* map of a normal human heart to correct T2* segmental artefacts; myocardial iron overload and fibrosis in thalassemia intermedia versus thalassemia major patients and electrocardiogram changes in thalassemia major patients.
Studies of the standardized, 3D, 16-segments map of the circumferential distribution of T2* values, of cardiovascular magnetic resonance (CMR) in thalassemia major (TM) and thalassemia intermedia (TI) patients and of electrocardiogram (ECG) changes associated with TM, have been carried out. Similarly, the segment-dependent correction map of the T2* values and the artifactual variations in normal subjects and the T2* correction map to correct segmental measurements in patients with different levels of myocardial iron burden have been evaluated. Cardiovascular magnetic resonance can be a suitable guide to cardiac management in TI, as well as in TM; TI patients show lower myocardial iron burden and more pronounced high cardiac output findings than TM patients. Moreover, it is proposed that, due to its good positive predictive value (PPV) and low cost, ECG can be a suitable guide to orient towards CMR examination in TM cases.
Ramazzotti
Anna
A
Magnetic Resonance Imaging Laboratory, Institute of Clinical Physiology, CNR, Pisa, Italy. miot@ifc.cnr.it
Pepe
Alessia
A
Positano
Vincenzo
V
Scattini
Barbara
B
Santarelli
Maria F
MF
Landini
Luigi
L
De Marchi
Daniele
D
Keilberg
Petra
P
Derchi
Giorgio
G
Formisano
Francesco
F
Pili
Marcello
M
Lai
Maria E
ME
Forni
Gianluca
G
Filosa
Aldo
A
Prossomariti
Luciano
L
Capra
Marcello
M
Pitrolo
Lorella
L
Borgna-Pignatti
Caterina
C
Cianciulli
Paolo
P
Maggio
Aurelio
A
Lombardi
Massimo
M
D000328:Adult; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D005355:Fibrosis; D006801:Humans; D019190:Iron Overload / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D013789:Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology