title: [Influence of chemical analogue of extracellular microbial autoregulators on antilysozyme activity of bacteria].
abstract: Modifying action of C7-alkyloxybenzol (methylresorcin) on the antilysozyme activity (ALA) of opportunistic microorganisms (Bacillus cereus, Klebsiella pneumoniae, and Escherichia coli) was studied. C7-alkyloxybenzol (C7-AOB, methylrezorcin), which was used as chemical analogue of microbial autoregulators, was added to growth medium containing microorganisms, which were cultivated until entered stationary phase. Isolation of clones was performed by seeding of 24-hours broth culture on solid growth medium, and then ALA was measured using photometric method. Modifying action of C7-AOB on ALA characteristic-based population structure of B.cereus, K. pneumoniae, and E. coli was revealed. Maximal effect was detected when the concentration of C7-AOB was in range 1-10 mcg/ml. Decrease of mean ALA level caused by C7-AOB was linked to decrease of proportion of clones with high and intermediate ALA level, increase of proportion of clones with low level of lysozyme inhibitor, and emergence of clones lacking ALA in the population.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
authors.forename: G I
authors.initials: GI
authors.lastname: El'-Registan
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Nikolaev
authors.forename: S V
authors.initials: SV
authors.lastname: Iavnova
authors.forename: E V
authors.initials: EV
authors.lastname: Molostov
authors.forename: D A
authors.initials: DA
authors.lastname: Kirillov
mesh_terms: D001409:Bacillus cereus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D018407:Bacterial Physiological Phenomena / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D009113:Muramidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009930:Organic Chemicals / Q000494:pharmacology; D012118:Resorcinols / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D009930:Organic Chemicals; D012118:Resorcinols; C005282:orcinol; D009113:Muramidase