Increased serum CXCL16 level is a marker for acute coronary syndromes.
BACKGROUND
CXCL16 is a transmembrane molecule combining scavenger receptor functions with the properties of an inflammatory chemokine. Accumulating evidence suggests that CXCL16 is involved in atherosclerosis; however, the role of circulating soluble CXCL16 in human coronary artery disease remains unclear.


METHODS
ELISA was used to examine the concentration of serum-soluble CXCL16 in 26 stable angina pectoris patients (SAP), 29 acute coronary syndrome (ACS) patients and 21 control patients.


RESULTS
In patients with ACS, serum level of CXCL16 was significantly increased compared to control and SAP patients (p <0.001 vs. control; p = 0.041 vs. SAP patients); serum levels of CXCL16 in patients with SAP were higher than in control patients although no statistical significance was found (p = 0.059). No significant association was found between serum CXCL16 and acute-phase reactants, TNF-alpha, or serum lipid parameters. In ACS patients, increased level of serum CXCL16 was not linked to either the severity of coronary stenosis or TIMI risk score, which is an early risk evaluation system for ACS.


CONCLUSIONS
Increased level of serum-soluble CXCL16 was independently associated with ACS.
Sun
Ying
Y
Beijing Tong Ren Hospital, Capital Medical University, Beijing, PR China.
Chang
Zhiwen
Z
Zhang
Sujuan
S
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000473:pathology; D000209:Acute-Phase Proteins / Q000378:metabolism; D000368:Aged; D015415:Biomarkers; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood*; D003251:Constriction, Pathologic / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051116:Receptors, Scavenger / Q000097:blood*; D012307:Risk Factors; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000209:Acute-Phase Proteins; D015415:Biomarkers; C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D008074:Lipoproteins; D051116:Receptors, Scavenger; D014409:Tumor Necrosis Factor-alpha