title: Total synthesis of +-superstolide A.
abstract: A convergent and highly stereocontrolled synthesis of +-superstolide A (1) has been accomplished. Key steps of this synthesis include the intramolecular Suzuki reaction of 26 and the highly diastereoselective transannular Diels-Alder cyclization of macrocyclic octaene 3.
authors.affiliation: Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA.
authors.forename: Mariola
authors.initials: M
authors.lastname: Tortosa
authors.forename: Neal A
authors.initials: NA
authors.lastname: Yakelis
authors.forename: William R
authors.initials: WR
authors.lastname: Roush
mesh_terms: D003500:Cyclization; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003603:Cytotoxins; D018942:Macrolides; D013764:Tetrahydronaphthalenes; C091984:superstolide A