A patient with melorheostosis manifesting with features similar to tricho-dento-osseous syndrome: a case report.
BACKGROUND
A case of melorheostosis in association with tricho-dento-osseous (TDO) syndrome has been encountered.


METHODS
The clinical and the radiographic manifestations of melorheostosis have been encountered in a 41-year-old man. Mutations in the 13 exons and flanking intronic regions of the LEMD3-gene have not been detected. His phenotypic features were consistent but not completely diagnostic for tricho-dento-osseous syndrome (TDO). We report what might be a novel syndromic association.


CONCLUSIONS
Melorheostosis has not previously been reported to be a part of TDO and an extensive review of the literature suggests that the constellation of hair, tooth and bone abnormalities found in our patient either represents an unusual variant of tricho-dento-osseous syndrome or a new syndrome.
Al Kaissi
Ali
A
Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Hanusch Hospital, Vienna, Austria. ali.alkaissi@osteologie.at
Skoumal
Martin
M
Roetzer
Katharina
K
Grill
Franz
F
Klaushofer
Klaus
K