title: Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis.
abstract: OBJECTIVE
  To determine serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up.
  
  
  METHODS
  This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17).
  
  
  RESULTS
  At the time of diagnosis, serum IL-1beta, IL-6, IL-8, and TNF-alpha levels of culture-proven sepsis were significantly higher than those of the control groups (P<.05). At the time of diagnosis, IL-1beta, IL-6, IL-8, and TNF-alpha levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment.
  
  
  CONCLUSIONS
  Serum IL-1beta, IL-6, IL-8, and TNF-alpha are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, Turkey. nkurt@firat.edu.tr
authors.forename: A Nese Citak
authors.initials: AN
authors.lastname: Kurt
authors.forename: A Denizmen
authors.initials: AD
authors.lastname: Aygun
authors.forename: Ahmet
authors.initials: A
authors.lastname: Godekmerdan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kurt
authors.forename: Yasar
authors.initials: Y
authors.lastname: Dogan
authors.forename: Erdal
authors.initials: E
authors.lastname: Yilmaz
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology; D002633:Chemotaxis; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha