title: Exercise and food ad libitum reduce the impact of early in life nutritional inbalances on nitrergic activity of hippocampus and striatum.
abstract: Nutritional imbalances were produced by varying litter size pups per dam: 3 (small), 6 (medium), and 12 (large). On the 21st day, 4 subjects of each litter, were sacrificed and the remaining were grouped, 2 per cage, with or without running wheels, with food and water ad libitum. Adult subjects were tested in water maze, their brains processed for NADPH-diaphorase histochemistry and quantified by densitometry. No differences were detected in water maze. At 21st day, S and L compared with M presented reduced NADPH-d in the stratum molecular of dentate gyrus (DG), stratum lacunosum of CA1 and in all CA3 layers but not in the striatum. On the 58th day, actvity remained low in S and L in CA3 and striatum and L in CA1 and DG. Voluntary exercise increased NADPH-d in DG, CA1, CA3, and striatum in S, and in the stratum lacunosum of CA1 and CA3 in L.
authors.affiliation: Departamento de Morfologia, Universidade Federal do Pará, CEP 66075900 Belém, PA, Brazil.
authors.forename: Lane Coelho
authors.initials: LC
authors.lastname: Viana
authors.forename: João Bento
authors.initials: JB
authors.lastname: Torres
authors.forename: José Augusto
authors.initials: JA
authors.lastname: Farias
authors.forename: Rafael
authors.initials: R
authors.lastname: Kawhage
authors.forename: Nara
authors.initials: N
authors.lastname: Lins
authors.forename: Aline
authors.initials: A
authors.lastname: Passos
authors.forename: Amanda
authors.initials: A
authors.lastname: Quintairos
authors.forename: Nonata
authors.initials: N
authors.lastname: Trévia
authors.forename: Rubem Carlos Araújo
authors.initials: RC
authors.lastname: Guedes
authors.forename: Cristovam Wanderley Picanço
authors.initials: CW
authors.lastname: Diniz
mesh_terms: D000375:Aging; D000818:Animals; D003342:Corpus Striatum / Q000201:enzymology / Q000254:growth & development*; D004032:Diet; D006624:Hippocampus / Q000201:enzymology / Q000254:growth & development*; D006651:Histocytochemistry; D008098:Litter Size; D008297:Male; D018782:Maze Learning; D051379:Mice; D009252:NADPH Dehydrogenase / Q000032:analysis / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D009752:Nutritional Status / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*
chemical_list: D009569:Nitric Oxide; D009252:NADPH Dehydrogenase