FERMing up the plasma membrane.
As cells enter mitosis, shape changes occur that involve rearrangements of the actin cytoskeleton and an increase in cortical stiffness. In a recent article in Current Biology, Kunda et al. describe a new role for ERM proteins in regulating rearrangements of the cortical cytoskeleton during mitosis.
Neisch
Amanda
A
Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA.
Fehon
Richard G
RG
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D048430:Cell Shape; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological; D024462:Myosin Type II / Q000378:metabolism; D017434:Protein Structure, Tertiary
D003598:Cytoskeletal Proteins; D008840:Microfilament Proteins; C071058:moesin; D024462:Myosin Type II