title: [A cellulose derivative with a potential to become an active pharmaceutical substance as well as an auxiliary substance].
abstract: The review article is focused on one of the wide range of pharmaceutically and medicinally employed cellulose derivates--oxycellulose. This substance, prepared by oxidation of cellulose, in contrast to cellulose esters and ethers, has not been not employed in practice in a wide extent yet. However, recent studies reveal its potential use in modern therapeutical systems, whether as a release-modifying excipient, a drug carrier, or also an active substance with ability of hemostasis, prevention of tissue adhesion after surgical operations, and a substance with antimicrobial and immunomodulating activity, whose unique property of biodegradability, promoted by hypoallergenicity and non-irritability, has not been observed in any of the hitherto used cellulose derivates. The article presents a comprehensive overview about the history of this derivate, from its physico-chemical properties through the description of the ability of biodegradability to its already realized and planned utilization.
authors.affiliation: Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ustav technologie léků. gazi007@seznam.cz
authors.forename: J
authors.initials: J
authors.lastname: Gajdziok
authors.forename: M
authors.initials: M
authors.lastname: Bajerová
authors.forename: Z
authors.initials: Z
authors.lastname: Chalupová
authors.forename: R
authors.initials: R
authors.lastname: Masteiková
mesh_terms: D002626:Chemistry, Pharmaceutical; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives*; D010592:Pharmaceutic Aids
chemical_list: D010592:Pharmaceutic Aids; D065347:Hypromellose Derivatives; D008747:Methylcellulose