Expanding chemical biology of 2-oxoglutarate oxygenases.
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
Loenarz
Christoph
C
Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk
Schofield
Christopher J
CJ
D000818:Animals; D002384:Catalysis; D006657:Histones / Q000737:chemistry / Q000502:physiology; D006801:Humans; D006900:Hydroxylation; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008745:Methylation; D008958:Models, Molecular; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry; D010084:Oxidation-Reduction; D010105:Oxygenases / Q000737:chemistry* / Q000502:physiology*; D011506:Proteins / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013237:Stereoisomerism
D006657:Histones; D007656:Ketoglutaric Acids; D009696:Nucleic Acids; D011506:Proteins; D010105:Oxygenases