Griseusin D, a new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp.
A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5'-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC(50) values of 0.23 and 19.6 microg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 microg/ml.
Li
Yi-Qing
YQ
Laboratory for Conservation and Utilization of Bio-resources, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan, China.
Li
Ming-Gang
MG
Li
Wei
W
Zhao
Jiang-Yuan
JY
Ding
Zhang-Gui
ZG
Cui
Xiao-Long
XL
Wen
Meng-Liang
ML
D000192:Actinomycetales / Q000378:metabolism*; D000528:Alternaria / Q000187:drug effects; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D003470:Culture Media / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013057:Spectrum Analysis
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D003470:Culture Media; D009285:Naphthoquinones; C012339:griseusin