title: Oxidative stress in patients with benign prostate hyperplasia.
abstract: Benign Prostate Hyperplasia (BPH) is a common health problem in aging male. Free radicals and Reactive Oxygen Species (ROS) are produced in overwhelming quantity with advancement of age. When in oxidative stress, these reactive species cause extensive damage to various organ in the body, may be associated with pathogenesis of BPH also. This study aimed at assessing Malondialdehyde (MDA), the marker of lipid peroxidation and anti-oxidants e.g. alpha-Tocopherol and Ascorbate status in plasma in BPH patients. Forty eight (n=48) cases of BPH and forty six (n = 46) healthy age matched controls were enrolled. Plasma MDA level showed 4.81+/-1.87 nmol/ml in cases compared to 3.69+/-1.56 nmol/ml in healthy controls (p<0.001). There were significant decrease in plasma alpha-Tocopherol and ascorbate level which were 0.85+/-0.12 mg/dl and 0.93 +/- 0.13 mg/dl in cases compared to 1.37+/-0.31 mg/dl and 1.44+/-0.38 mg/dl in healthy controls respectively. Inverse correlation of plasma MDA with alpha-Tocopherol (r = -0.09, p>0.05) and Ascorbate (r =-0.51, p=0.008) was found in BPH patients. There was mild elevation of PSA in BPH patients compared with control but was not statistically significant. Thus, our study showed the evidence of association of oxidative stress in BPH patients.
authors.affiliation: Department of Biochemistry, B P Koirala Institute of Health Sciences, Dharan, Nepal.
authors.forename: M
authors.initials: M
authors.lastname: Aryal
authors.forename: A
authors.initials: A
authors.lastname: Pandeya
authors.forename: B K
authors.initials: BK
authors.lastname: Bas
authors.forename: M
authors.initials: M
authors.lastname: Lamsal
authors.forename: S
authors.initials: S
authors.lastname: Majhi
authors.forename: R
authors.initials: R
authors.lastname: Pandit
authors.forename: C S
authors.initials: CS
authors.lastname: Agrawal
authors.forename: N
authors.initials: N
authors.lastname: Gautam
authors.forename: N
authors.initials: N
authors.lastname: Baral
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D018384:Oxidative Stress; D011470:Prostatic Hyperplasia / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde