title: Functional topography of early periventricular brain lesions in relation to cytoarchitectonic probabilistic maps.
abstract: Early periventricular brain lesions can not only cause cerebral palsy, but can also induce a reorganization of language. Here, we asked whether these different functional consequences can be attributed to topographically distinct portions of the periventricular white matter damage. Eight patients with pre- and perinatally acquired left-sided periventricular brain lesions underwent focal transcranial magnetic stimulation to assess the integrity of cortico-spinal hand motor projections, and functional MRI to determine the hemispheric organization of language production. MRI lesion-symptom mapping revealed that two distinct portions of the periventricular lesions were critically involved in the disruption of cortico-spinal hand motor projections on the one hand and in the induction of language reorganization into the contra-lesional right hemisphere on the other hand. Both regions are located in a position compatible with the course of cortico-spinal/cortico-nuclear projections of the primary motor cortex in the periventricular white matter, as determined by the stereotaxic probabilistic cytoarchitectonic atlas developed by the Jülich group.
authors.affiliation: Department of Pediatric Neurology and Developmental Medicine, University Children's Hospital, Hoppe-Seyler-Str. 1, D-72076 Tübingen, Germany. martin.staudt@med.uni-tuebingen.de
authors.forename: Martin
authors.initials: M
authors.lastname: Staudt
authors.forename: Luca F
authors.initials: LF
authors.lastname: Ticini
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grodd
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Krägeloh-Mann
authors.forename: Hans-Otto
authors.initials: HO
authors.lastname: Karnath
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006429:Hemiplegia / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D011712:Pyramidal Tracts / Q000473:pathology / Q000503:physiopathology; D013060:Speech / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods