title: Isolation of 8'-phosphate ester derivatives of amicoumacins: structure-activity relationship of hydroxy amino acid moiety.
abstract: Two new compounds, 8'-phospho derivatives of amicoumacins A and B, were isolated from the culture broth of a strain of Bacillus pumilus together with amicoumacins A and B. Their structures were elucidated on the basis of spectroscopic methods and alkaline phosphatase treatments. Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8' hydroxyl and C-12' amide group of amicoumacin A played a critical role for anti-MRSA activity.
authors.affiliation: Reseach Institute of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishitokyo, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Takaaki
authors.initials: T
authors.lastname: Taguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishida
authors.forename: Kouji
authors.initials: K
authors.lastname: Ueno
authors.forename: Kaio
authors.initials: K
authors.lastname: Koizumi
authors.forename: Masaki
authors.initials: M
authors.lastname: Aburada
authors.forename: Koji
authors.initials: K
authors.lastname: Ichinose
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; C031379:amicoumacin A; D000469:Alkaline Phosphatase