Taurine-diabetes interaction: from involvement to protection.
Taurine is a sulfur amino acid (2-amino ethane sulfonic acid) and has been claimed for a number of beneficial actions ranging from anti-epilepsy to anti-hypertension. Taurine in diabetes has an age old story; taurine is involved in the development and protection of insulin apparatus. Taurine and insulin both have mutual stimulating actions with hypoglycemic properties. On the clinical front, taurine supplementation has an acceptable beneficial effect in platelet aggregation and, to name few more, in neuropathy, cardiomyopathy, and nephropathy to retinopathy. Recent studies have provided a role for taurine in fetal development and in blocking the transfer of diabetes from diabetic mother to offspring. A number of mechanisms for the actions of taurine have been advocated, from osmoregulation to anti-oxidation. Though sulfonylurea and recently introduced thiazolidinediones are effective, however they are not free from complications, thus there is a need to design new therapeutics. As taurine is also a sulfonyl derivative, it will be of great interest to develop taurine analogues as an alternative therapy. Considering the great involvement of taurine in diabetes, this review may provide a holistic view of taurine in diabetes and in its prevention in this century.
Kim
S-J
SJ
Department of Pharmacology, Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University, Seoul, Korea. kimsj@khu.ac.kr
Ramesh
C
C
Gupta
H
H
Lee
W
W
D000375:Aging / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D048909:Diabetes Complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D015444:Exercise / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D013654:Taurine / Q000502:physiology / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000975:Antioxidants; D013654:Taurine