Gymnastatins and dankastatins, growth inhibitory metabolites of a gymnascella species from a Halichondria sponge.
Four new metabolites, gymnastatins Q ( 3) and R ( 4) and dankastatins A ( 5) and B ( 6), have been isolated from the mycelial MeOH extract of a fungal strain of Gymnascella dankaliensis separated from a Halichondria sponge. Their stereostructures have been established on the basis of spectroscopic analysis using 1D and 2D NMR techniques. All of the isolated metabolites ( 3- 6) exhibited growth inhibition against the P388 cancer cell line. Furthermore, gymnastatin Q ( 3) showed appreciable growth inhibition against BSY-1 (breast) and MKN7 (stomach) human cancer cell lines.
Amagata
Taro
T
Osaka University of Pharmaceutical Sciences, Osaka, Japan.
Tanaka
Makoto
M
Yamada
Takeshi
T
Minoura
Katsuhiko
K
Numata
Atsushi
A
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007564:Japan; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology
D000970:Antineoplastic Agents; D001578:Benzopyrans; D001952:Bridged-Ring Compounds; C528785:dankastatin A; C528786:dankastatin B; C528783:gymnastatin Q; C528784:gymnastatin R