Corrective effect of flavonoid-containing preparation Extralife on the development of Parkinson's syndrome.
Oral administration of flavonoid-containing preparation Extralife (daily dose 40 mg/kg) to animals with modeled Parkinson's syndrome considerably improved their survival and the main diagnostic and nosological parameters characterizing the state of locomotor functions. The preparation decreased animal mortality, rigidity, disturbances in dynamic muscular work and coordination of movements, and reduced oligokinesia. Experimental data confirm the involvement of mitochondrial enzyme complex I dysfunction in the pathogenesis of the disease and showed the possibility of by-passing this site of the respiratory chain with Extralife.
Luk'yanova
L D
LD
Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Storozheva
Z I
ZI
Proshin
A T
AT
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000375:Aging; D000818:Animals; D005419:Flavonoids / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D027824:Rosaceae / Q000737:chemistry
D005419:Flavonoids; D010936:Plant Extracts; C527119:extralife; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine