title: MMPI measures as signs of predisposition to mental disorder among adoptees at high risk for schizophrenia.
abstract: The DSM-III-R diagnoses of a group of adoptees were predicted by the MMPI (Minnesota Multiphasic Personality Inventory) schizophrenia-related scales in the Finnish Adoptive Family Study. The sample consisted of 60 high-risk (HR) adopted-away offspring of biologic mothers with a diagnosis of broad schizophrenia spectrum and 76 low-risk (LR) control adoptees. They were assessed with the MMPI before the onset of any psychiatric disorder at a mean age of 24 years. High scores on the Psychopathic Deviate scale predicted psychiatric disorder at 11-year follow-up. Furthermore, LR adoptees', but not HR adoptees', mental disorders could be predicted with the MMPI scales Psychopathic Deviate and Golden-Meehl Indicators. These scales measure schizophrenia-related personality traits, including a social behavior, anhedonia, ambivalence, interpersonal aversiveness, and formal thought disturbances.
authors.affiliation: Department of Psychiatry, University of Oulu, Oulu, Finland. virva.siira@oulu.fi <virva.siira@oulu.fi>
authors.forename: Virva
authors.initials: V
authors.lastname: Siira
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Wahlberg
authors.forename: Jouko
authors.initials: J
authors.lastname: Miettunen
authors.forename: Kristian
authors.initials: K
authors.lastname: Läksy
authors.forename: Pekka
authors.initials: P
authors.lastname: Tienari
mesh_terms: D000293:Adolescent; D000300:Adoption / Q000523:psychology*; D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000453:epidemiology; D000367:Age Factors; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology* / Q000706:statistics & numerical data; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D007398:Interpersonal Relations; D008137:Longitudinal Studies; D008950:MMPI / Q000706:statistics & numerical data*; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D010552:Personality Assessment; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D012565:Schizophrenic Psychology; D012919:Social Behavior; D012923:Social Class