Exercise and food ad libitum reduce the impact of early in life nutritional inbalances on nitrergic activity of hippocampus and striatum.
Nutritional imbalances were produced by varying litter size pups per dam: 3 (small), 6 (medium), and 12 (large). On the 21st day, 4 subjects of each litter, were sacrificed and the remaining were grouped, 2 per cage, with or without running wheels, with food and water ad libitum. Adult subjects were tested in water maze, their brains processed for NADPH-diaphorase histochemistry and quantified by densitometry. No differences were detected in water maze. At 21st day, S and L compared with M presented reduced NADPH-d in the stratum molecular of dentate gyrus (DG), stratum lacunosum of CA1 and in all CA3 layers but not in the striatum. On the 58th day, actvity remained low in S and L in CA3 and striatum and L in CA1 and DG. Voluntary exercise increased NADPH-d in DG, CA1, CA3, and striatum in S, and in the stratum lacunosum of CA1 and CA3 in L.
Viana
Lane Coelho
LC
Departamento de Morfologia, Universidade Federal do Pará, CEP 66075900 Belém, PA, Brazil.
Torres
João Bento
JB
Farias
José Augusto
JA
Kawhage
Rafael
R
Lins
Nara
N
Passos
Aline
A
Quintairos
Amanda
A
Trévia
Nonata
N
Guedes
Rubem Carlos Araújo
RC
Diniz
Cristovam Wanderley Picanço
CW
D000375:Aging; D000818:Animals; D003342:Corpus Striatum / Q000201:enzymology / Q000254:growth & development*; D004032:Diet; D006624:Hippocampus / Q000201:enzymology / Q000254:growth & development*; D006651:Histocytochemistry; D008098:Litter Size; D008297:Male; D018782:Maze Learning; D051379:Mice; D009252:NADPH Dehydrogenase / Q000032:analysis / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D009752:Nutritional Status / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*
D009569:Nitric Oxide; D009252:NADPH Dehydrogenase