title: Administration of 75 mg of aspirin daily for 28 days is sufficient prophylaxis against renal transplant vein thrombosis.
abstract: BACKGROUND
  Early postoperative renal transplant vein thrombosis results in graft loss. We evaluate the effect of administering aspirin 75 mg daily for 28 days following transplantation.
  
  
  METHODS
  Prospectively collected data on the outcome of all transplants undertaken in our unit in the five-year period from January 1997 to January 2002 were reviewed, and in cases of graft failure before three months the cause was defined.
  
  
  RESULTS
  In the study period, a total of 401 transplants were undertaken (311 cadaveric and 90 living related). There was one case of renal transplant vein thrombosis (0.25%). This represents a significant reduction on the unit's historical incidence of 5.8%, P < 0.001.
  
  
  CONCLUSIONS
  Aspirin 75 mg daily is adequate to virtually abolish renal transplant vein thrombosis and has a role in thromboprophylaxis in other situations where heparin is contraindicated.
authors.affiliation: The Oxford Transplant Centre, Churchill Hospital, Headington, Oxford, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Stechman
authors.forename: N
authors.initials: N
authors.lastname: Charlwood
authors.forename: D W R
authors.initials: DW
authors.lastname: Gray
authors.forename: A
authors.initials: A
authors.lastname: Handa
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage*; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000209:etiology / Q000517:prevention & control*
chemical_list: D005343:Fibrinolytic Agents; D001241:Aspirin