Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases.
We report the first unambiguous syntheses of glucitol-1,6-bis-phosphate and mannitol-1,6-bis-phosphate and their competitive inhibition of various fructose bis-phosphate aldolases.
Mabiala-Bassiloua
Charles-Gabin
CG
ECBB, ICMMO, Univ Paris-Sud, UMR 8182, F-91405 Orsay, France.
Zwolinska
Magdalena
M
Therisod
Helene
H
Sygusch
Jurgen
J
Therisod
Michel
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors*; D016480:Helicobacter pylori / Q000201:enzymology; D008355:Mannitol Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013403:Sugar Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008355:Mannitol Phosphates; D013403:Sugar Phosphates; C528894:glucitol-1,6-bis-phosphate; C528895:mannitol-1,6-bis-phosphate; D013012:Sorbitol; D005634:Fructose-Bisphosphate Aldolase