title: Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study.
abstract: Ischemia-modified albumin (IMA) is a sensitive marker of myocardial ischemia, skeletal muscle ischemia, pulmonary embolism, and stroke. However, there are no studies showing whether IMA increases in mesenteric ischemia. The aim of this study was to determine whether IMA was elevated in acute mesenteric ischemia. This case-controlled study was performed in an emergency department of a university hospital. The measurement of IMA levels in patient plasma yielded means of 0.264 +/- 0.057 absorbance units (ABSU) in the thromboembolic occlusion of the superior mesenteric artery (SMA) group and 0.163 +/- 0.025 ABSU in the control group. When plasma IMA levels in the thromboembolic occlusion SMA group were compared with those in the control group, statistically significant increases in IMA were observed in the occlusion group (P = .003). Findings indicating that IMA may have a place in the diagnosis of acute mesenteric embolism were obtained in this preliminary study. Further prospective studies are needed to see if IMA is clinically useful in the early detection of thromboembolic occlusion of the SMA.
authors.affiliation: Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, 61080 Trabzon, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Gunduz
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turedi
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: Suleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.forename: Gultekin
authors.initials: G
authors.lastname: Hos
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tatli
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turan
authors.forename: Utku
authors.initials: U
authors.lastname: Ucar
authors.forename: Robert Michael
authors.initials: RM
authors.lastname: Russell
authors.forename: Murat
authors.initials: M
authors.lastname: Topbas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000032:analysis*; D016022:Case-Control Studies; D004636:Emergency Service, Hospital; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia; D008297:Male; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000097:blood* / Q000175:diagnosis* / Q000601:surgery; D013152:Splanchnic Circulation
chemical_list: D000418:Albumins