title: Paternal skeletal size predicts intrauterine bone mineral accrual.
abstract: BACKGROUND
  We have previously demonstrated that maternal body build and lifestyle factors predict neonatal bone mineral accrual. However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring.
  
  
  METHODS
  A total of 278 pregnancies (142 male and 136 female neonates) were recruited from the Southampton Women's Survey, a unique, well-established cohort of women, aged 20-34 yr, who had been assessed before and during pregnancy. The neonates and their fathers underwent whole body dual-x-ray absorptiometry (DXA) within 2 wk of birth using a Lunar DPX (General Electric Corp., Madison, WI) and Hologic Discovery instrument (Hologic Inc., Bedford, MA), respectively; correlation and regression methods were used to explore the parental determinants of neonatal bone mass.
  
  
  RESULTS
  After adjusting the paternal DXA indices for father's age and the neonatal for baby's gestational age and age at DXA scan, there were highly significant positive associations between baby's whole body bone area, bone mineral content, and bone mineral density and the corresponding indices in the father (P = 0.003, 0.0002, 0.046, respectively) among female infants. These relationships were independent of maternal height and fat stores. The associations for male infants with paternal DXA indices did not achieve statistical significance.
  
  
  CONCLUSIONS
  The father's skeletal size predicts skeletal size more strongly in female than male offspring, independently of the mother's body build. These data point toward the importance of considering paternal genotype in studies exploring the developmental origins of osteoporotic fracture and raise intriguing mechanistic questions about the gender specificity of influences on intrauterine bone mineral accrual.
authors.affiliation: Medical Research Council Epidemiology Resource Centre, University of Southampton, and Southampton General Hospital, Southampton, United Kingdom.
authors.forename: N C
authors.initials: NC
authors.lastname: Harvey
authors.forename: M K
authors.initials: MK
authors.lastname: Javaid
authors.forename: J R
authors.initials: JR
authors.lastname: Poole
authors.forename: P
authors.initials: P
authors.lastname: Taylor
authors.forename: S M
authors.initials: SM
authors.lastname: Robinson
authors.forename: H M
authors.initials: HM
authors.lastname: Inskip
authors.forename: K M
authors.initials: KM
authors.lastname: Godfrey
authors.forename: C
authors.initials: C
authors.lastname: Cooper
authors.forename: E M
authors.initials: EM
authors.lastname: Dennison
mesh_terms: D000328:Adult; D001724:Birth Weight; D015519:Bone Density; D001846:Bone Development; D001842:Bone and Bones / Q000033:anatomy & histology*; D005220:Fathers; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D012727:Sex Characteristics