title: Health-related quality of life in inflammatory bowel disease patients: the role of psychopathology and personality.
abstract: BACKGROUND
  The present study aimed at assessing whether psychological factors, specifically psychopathology and personality, together with clinical and sociodemographic factors, were independent predictors of quality of life (QoL) in patients with inflammatory bowel disease (IBD).
  
  
  METHODS
  A cohort of 147 outpatients with IBD was enrolled in the study. Clinical and sociodemographic variables were recorded. QoL was assessed by the Inflammatory Bowel Disease Questionnaire (IBDQ); personality traits were assessed by means of the Temperament and Character Inventory; and psychopathology was evaluated by the Hospital Anxiety and Depression Scale. To explore the relation of variables on the QoL, univariate analyses were performed for each variable. Factors statistically significant at these analyses were included in a multiple linear regression analysis with dimensional and global IBDQ scores as dependent variables.
  
  
  RESULTS
  Some clinical and psychological factors were related with QoL, but regression analysis showed that disease activity and psychological distress were the strongest predictors of QoL impairment. Personality traits do not play a significant role in QoL.
  
  
  CONCLUSIONS
  The presence of psychological distress in IBD patients contributes to poor QoL, along with IBD clinical activity. Controlling and minimizing the symptoms of the disease, along with identification and treatment of psychopathology, should become integral aspects of IBD care to improve QoL of these patients.
authors.affiliation: Department of Clinical Psychology, Hospital Clínic de Barcelona, CIBER-EHD, Institut Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. anvidal@clinic.ub.es
authors.forename: Angela
authors.initials: A
authors.lastname: Vidal
authors.forename: Esther
authors.initials: E
authors.lastname: Gómez-Gil
authors.forename: Miquel
authors.initials: M
authors.lastname: Sans
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Portella
authors.forename: Manel
authors.initials: M
authors.lastname: Salamero
authors.forename: Josep M
authors.initials: JM
authors.lastname: Piqué
authors.forename: Julián
authors.initials: J
authors.lastname: Panés
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000523:psychology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010551:Personality; D011613:Psychotherapy; D011788:Quality of Life; D012044:Regression Analysis; D011795:Surveys and Questionnaires