[Clinical and pathogenetic mechanisms of the formation of complicated course of I type diabetes mellitus in children].
The article presents the review of literature related to the analysis of current theories of the development of complicated I type diabetes mellitus in children. Special attention is given to the mechanisms of formation of late complications and in particular diabetic neuropathies. It is underlined, that the most important in pathogenesis of diabetic involvement of the nervous system is metabolic disorders, oxidizing stress, autoimmune processes. Microangiopathy plays certain role in formation of diabetic neuropathies, leading to disorders of microcirculation and hypoxia of nerves.
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D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism