[Combination of operation, chemotherapy and radiation for AFP producing gastric cancer--a case report].
We report a case of AFP producing gastric cancer after a combination of operation, chemotherapy and radiation. A 70-year-old man was admitted complaining of abdominal fullness. He was diagnosed as having type 3 advanced gastric cancer with multiple lymph node metastasis, including No. 8p lymph node, by endoscopy and computed tomography. Distal gastrectomy and D2 lymph node dissection were performed after chemotherapy using S-1, low-dose CDDP and CPT-11. Histopathological study showed moderately differentiated adenocarcinoma, and immunohistochemical study revealed a few AFP-positive tumor cells. Postoperatively, radiation (50 Gy) was performed for paraaortic lymph node metastasis and right hepatic lobectomy for liver metastasis. However, about 2 months after hepatic lobectomy, liver metastasis was diagnosed again by computed tomography, and radiation (30 Gy) was performed. He died 13 months after first surgery.
Nakamura
Hiroyuki
H
Federation of Public Services and Affiliated Personnel Aid Associations, Dept. of Surgery, Hiroshima Memorial Hospital.
Nakai
Shiro
S
Morifuji
Masahiko
M
Fujimoto
Mikio
M
Miyamoto
Katsunari
K
Yokoyama
Yujiro
Y
D000368:Aged; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000378:metabolism*
C097353:AFP protein, human; D000509:alpha-Fetoproteins