title: Implementation of a stroke thrombolysis service within a tertiary neurosciences centre in the United Kingdom.
abstract: BACKGROUND
  Intravenous alteplase is licensed for treatment of ischaemic stroke within 3 h of onset. Up to one-third of patients in the UK present to hospital within this time window but few are treated.
  
  
  OBJECTIVE
  To examine the effect of a stroke thrombolysis protocol on service provision for an acute stroke service in the UK, jointly run by Neurology and Medicine for the Elderly providing a comprehensive stroke service to a local population of 370,000.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Data collected prospectively for all thrombolysis referrals over a 12-month period beginning July 2004.
  
  
  RESULTS
  One hundred and eighty-eight patients were referred for potential thrombolysis, 129 transferred, 102 had an ischaemic stroke and 49 received intravenous thrombolysis. Referral rates from primary care and accident and emergency increased after guideline dissemination. Forty-three percent of the 49 patients treated with intravenous rt-PA achieved independence (modified Rankin Scale score 0-2) at 3months.
  
  
  CONCLUSIONS
  A high proportion of ischaemic stroke patients can be treated with alteplase within 3 h of onset with organized hospital services and dissemination of a simple referral protocol to local primary and secondary care services.
authors.affiliation: Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, UK. michael.mccormick@clinmed.gla.ac.uk
authors.forename: Michael T
authors.initials: MT
authors.lastname: McCormick
authors.forename: Ian
authors.initials: I
authors.lastname: Reeves
authors.forename: Tracey
authors.initials: T
authors.lastname: Baird
authors.forename: Ian
authors.initials: I
authors.lastname: Bone
authors.forename: Keith W
authors.initials: KW
authors.lastname: Muir
mesh_terms: D004812:Epidemiologic Methods; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D017410:Practice Guidelines as Topic; D012017:Referral and Consultation; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000592:standards* / Q000706:statistics & numerical data; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator