title: Aseptic meningitis in mixed connective tissue disease: cytokine and anti-U1RNP antibodies in cerebrospinal fluids from two different cases.
abstract: In this paper, we report two patients with mixed connective tissue disease (MCTD) who developed aseptic meningitis. In both cases, the concentrations of IFN-gamma and IL-6 in cerebrospinal fluid (CSF) were increased. In the first case, with non-steroidal anti-inflammatory drugs (NSAIDs)-induced meningitis, where anti-U1RNP antibodies (Abs) were not detected in CSF, NSAIDs induced both IFN-gamma and IL-6 secretion from peripheral blood mononuclear cells in vitro. In the second case, with disease-associated meningitis, anti-U1RNP Abs were detected also in CSF. Of note, anti-U1RNP Abs appeared to be more concentrated in CSF than in serum and CSF-anti-U1RNP Ab titer was correlated with disease activity. We suggest that IFN-gamma and IL-6 may be involved in both disease-associated and drug-induced aseptic meningitis, whereas CSF-anti-U1RNP Abs is detected only in a patient with MCTD-associated aseptic meningitis.
authors.affiliation: Department of Rheumatology, Utano National Hospital, Kyoto, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Fujita
authors.forename: Takao
authors.initials: T
authors.lastname: Fujii
authors.forename: Ran
authors.initials: R
authors.lastname: Nakashima
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001323:Autoantibodies / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000134:cerebrospinal fluid; D015847:Interleukin-4 / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology*; D008947:Mixed Connective Tissue Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001323:Autoantibodies; D016207:Cytokines; D015850:Interleukin-6; D017412:Ribonucleoprotein, U1 Small Nuclear; D015847:Interleukin-4; D007371:Interferon-gamma; D011239:Prednisolone