Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation.
The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel-Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b-i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.
Scott
Robin H
RH
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Barnes
Colin
C
Gerhard
Ulrich
U
Balasubramanian
Shankar
S