title: Gastric emptying in healthy newborns fed an intact protein formula, a partially and an extensively hydrolysed formula.
abstract: OBJECTIVE
  Gastric emptying (GE) is influenced by the type of nutrition. The objective of this study was to compare GE in infants fed an intact protein formula (IPF), a partially hydrolysed formula (PHF), and an extensively hydrolysed formula (EHF).
  
  
  METHODS
  This was a double-blind, randomized, cross-over study. Following a fasting period of > or = 3 h, 20 healthy newborns were fed IPF, PHF, and EHF containing 50 microl (13)C-octanoic acid (OA). Breath samples were taken before feeding and every 15 min for 4 h thereafter. (13)C-OA breath test was assessed by isotope-ratio mass spectrometry, and GE half-times (t(1/2)) were determined.
  
  
  RESULTS
  Seventeen infants with a mean gestational age of 37 wk (range 28-40 wk) and birth weight of 2698 g (range 720-3690 g) completed the study. At study initiation, the mean age was 31 d (range 6 d-13 wk) and the mean weight was 3466 g (range 2100-5700 g). EHF emptied significantly faster than IPF and PHF (medians 46 vs. 55 and 53 min, respectively, Wilcoxon, P<0.05 for both). There was no significant difference between GE of PHF and IPF (Wilcoxon, P=0.2).
  
  
  CONCLUSIONS
  EHF may be better tolerated by infants with GE problems.
authors.affiliation: Pediatric Gastroenterology and Nutrition, Queen Paola Children's Hospital, ZNA, Lindendreef 1, 2018 Antwerp, Belgium.
authors.forename: Sofie
authors.initials: S
authors.lastname: Staelens
authors.forename: Mieke
authors.initials: M
authors.lastname: Van den Driessche
authors.forename: Denis
authors.initials: D
authors.lastname: Barclay
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Carrié-Faessler
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Haschke
authors.forename: Kristin
authors.initials: K
authors.lastname: Verbeke
authors.forename: Hilde
authors.initials: H
authors.lastname: Vandebroek
authors.forename: Karel
authors.initials: K
authors.lastname: Allegaert
authors.forename: Bart
authors.initials: B
authors.lastname: Van Overmeire
authors.forename: Mieke
authors.initials: M
authors.lastname: Van Damme
authors.forename: Gigi
authors.initials: G
authors.lastname: Veereman-Wauters
mesh_terms: D001944:Breath Tests / Q000379:methods*; D002210:Caprylates; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D004044:Dietary Proteins / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D006868:Hydrolysis; D007223:Infant; D007225:Infant Food; D041943:Infant Formula / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D007231:Infant, Newborn; D008297:Male
chemical_list: D002210:Caprylates; D002247:Carbon Isotopes; D004044:Dietary Proteins