title: Bending membranes on demand: fluid phospholipid bilayers on topographically deformable substrates.
abstract: We combine hierarchical surface wrinkling of elastomers with lipid membrane deposition techniques to dynamically template complex three-dimensional topographies onto supported lipid bilayers. The real-time introduction of corresponding nano- to micrometer scale curvatures triggers spatially periodic, elastic bending of the bilayer, accompanied by molecular-level reorganizations. This ability to dynamically impose curvatures on supported bilayers and the ensuing re-equilibration promises fundamental material and biophysical investigations of curvature-dependent, static heterogeneities and dynamic reorganizations pervasive in biological membranes.
authors.affiliation: Department of Applied Science and, Biophysics Graduate Group, University of California, Davis, California 95616, USA.
authors.forename: Babak
authors.initials: B
authors.lastname: Sanii
authors.forename: Andreia Michelle
authors.initials: AM
authors.lastname: Smith
authors.forename: Ravichandra
authors.initials: R
authors.lastname: Butti
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Brozell
authors.forename: Atul N
authors.initials: AN
authors.lastname: Parikh
mesh_terms: D008051:Lipid Bilayers / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D010743:Phospholipids / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008051:Lipid Bilayers; D010743:Phospholipids