title: Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).
abstract: There is a little information in literature about circulating asymmetric dimethylarginine (ADMA) concentrations in polycystic ovary syndrome (PCOS) and the results reported are discrepant. In this study, therefore, we aimed (1) to determine the circulating ADMA concentrations in 44 women with PCOS and 22 age- and BMI-matched healthy controls, (2) to evaluate its correlations with insulin resistance, gonadotrophins, and androgen secretion, and (3) to compare effects of metformin and ethinyl estradiol-cyproterone acetate (EE/CPA) treatments on circulating ADMA concentrations. In conclusion, our data indicate that circulating ADMA concentrations in non-obese, non-hypertensive and young women with PCOS are significantly higher than healthy controls and they improved by a 3-month course of metformin and oral contraceptive treatments.
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Ozgurtas
authors.forename: Cagatay
authors.initials: C
authors.lastname: Oktenli
authors.forename: Murat
authors.initials: M
authors.lastname: Dede
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Levent
authors.initials: L
authors.lastname: Kenar
authors.forename: S Yavuz
authors.initials: SY
authors.lastname: Sanisoglu
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yesilova
authors.forename: Mufit C
authors.initials: MC
authors.lastname: Yenen
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Erbil
authors.forename: Iskender
authors.initials: I
authors.lastname: Baser
mesh_terms: D000328:Adult; D000728:Androgens / Q000378:metabolism; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000494:pharmacology*; D017373:Cyproterone Acetate / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008687:Metformin / Q000494:pharmacology*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013997:Time Factors
chemical_list: D000728:Androgens; D003276:Contraceptives, Oral; D006062:Gonadotropins; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C018524:N,N-dimethylarginine; D008687:Metformin; D001120:Arginine