Expedient approach to chiral cyclobutanones: asymmetric synthesis of cyclobut-G.
An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.
Darses
Benjamin
B
Département de Chimie Moléculaire (SERCO) UMR-5250, ICMG FR-2607, CNRS Université Joseph Fourier BP 53, 38041 Grenoble Cedex 9, France.
Greene
Andrew E
AE
Coote
Susannah C
SC
Poisson
Jean-François
JF
D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D003503:Cyclobutanes; D006147:Guanine; C063638:lobucavir