[Activity of inflammatory-destructive changes in the process of formation of unstable atherosclerotic plaque].
We studied parameters of inflammatory (tumor necrosis factor a, antagonist of interleukin-1 receptor, interleukin-6 , interleukin-8, C-reactive protein) and destructive (matrix metalloproteinases type 3 and 9, tissue inhibitor of metalloproteinase type 1) processes in dynamics of sequential stages of development of atherosclerotic foci in coronary arteries: unchanged intimal tissue --> lipid stain/streak --> stable young plaque --> unstable vulnerable plaque with inclination to ulceration of rupture --> stable plaque with fibrosis/calcinosis, and in various types of unstable plaques in men with coronary atherosclerosis. Characteristic for unstable plaques parameters of inflammatory activity were elevated levels of interleukins (IL) 6 and 8, C-reactive protein (CRP), of destructive activity -- elevated level of metalloproteinases-9. In inflammatory erosive type of unstable plaques (lowered level of antagonist of interleukin-1 receptor and elevated level of CRP) and in lipid type (elevated levels of IL-6, IL-8 and CRP) inflammatory activity was dominating compared with necrotic type in which dominated destructive activity (elevated level of tumor necrosis factor a and lowered level of tissue inhibitor of metalloproteinase type 1).
Ragino
Iu I
IuI
Institute of Therapy, Vladimirsky spusk, 2a, 630003, Novosibirsk, Russia.
Cherniavskiĭ
A M
AM
Polonskaia
Ia V
IaV
Volkov
A M
AM
Semaeva
E V
EV
Voevoda
M I
MI
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D023921:Coronary Stenosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D045726:Metalloproteases / Q000378:metabolism*; D008875:Middle Aged; D012720:Severity of Illness Index
D015415:Biomarkers; D007378:Interleukins; D002097:C-Reactive Protein; D045726:Metalloproteases