title: IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
abstract: Emerging evidence supports the concept that T helper type 17 (T(H)17) cells, in addition to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. Interleukin-22 (IL-22) and IL-17A are both effector cytokines produced by the T(H)17 lineage, and both were crucial for maintaining local control of the Gram-negative pulmonary pathogen, Klebsiella pneumoniae. Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury. These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.
authors.affiliation: Children's Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Shean J
authors.initials: SJ
authors.lastname: Aujla
authors.forename: Yvonne R
authors.initials: YR
authors.lastname: Chan
authors.forename: Mingquan
authors.initials: M
authors.lastname: Zheng
authors.forename: Mingjian
authors.initials: M
authors.lastname: Fei
authors.forename: David J
authors.initials: DJ
authors.lastname: Askew
authors.forename: Derek A
authors.initials: DA
authors.lastname: Pociask
authors.forename: Todd A
authors.initials: TA
authors.lastname: Reinhart
authors.forename: Florencia
authors.initials: F
authors.lastname: McAllister
authors.forename: Jennifer
authors.initials: J
authors.lastname: Edeal
authors.forename: Kristi
authors.initials: K
authors.lastname: Gaus
authors.forename: Shahid
authors.initials: S
authors.lastname: Husain
authors.forename: James L
authors.initials: JL
authors.lastname: Kreindler
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Dubin
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Pilewski
authors.forename: Mike M
authors.initials: MM
authors.lastname: Myerburg
authors.forename: Carol A
authors.initials: CA
authors.lastname: Mason
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Iwakura
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D018925:Chemokines / Q000378:metabolism; D003550:Cystic Fibrosis / Q000276:immunology / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology; D053759:Interleukin-23 / Q000276:immunology; D007378:Interleukins / Q000276:immunology* / Q000378:metabolism; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae / Q000276:immunology* / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000382:microbiology; D008198:Lymph Nodes / Q000166:cytology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009500:Neutralization Tests; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology; D015854:Up-Regulation; D000097043:Interleukin-22
chemical_list: D018925:Chemokines; D020381:Interleukin-17; D053759:Interleukin-23; D007378:Interleukins; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C415369:interleukin-22 receptor