Focal segmental glomerulosclerosis: recent advances.
OBJECTIVE
Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children.


RESULTS
The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis.


CONCLUSIONS
A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.
Pollak
Martin R
MR
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. mpollak@rics.bwh.harvard.edu
D000818:Animals; D003599:Cytoskeleton / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D005919:Glomerular Filtration Rate; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D009404:Nephrotic Syndrome / Q000235:genetics / Q000473:pathology; D050199:Podocytes / Q000473:pathology; D012307:Risk Factors; D016896:Treatment Outcome
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C407223:NPHS2 protein