title: Hypothyroid myopathy with manifestations of Hoffman's syndrome and myasthenia gravis.
abstract: Although hypothyroid myopathy is seen frequently and the relationship with autoimmune hypothyroidism and myasthenia gravis is well known, specific forms of hypothyroid myopathy such as Hoffman's syndrome (HS) are rarely described. Here we describe a 40-year-old patient with Hashimoto thyroiditis showing symptoms and signs of two discrete forms of hypothyroid myopathy (HS and myasthenic syndrome) together. To our knowledge this is the first reported case with features of both of these syndromes. We discuss the diagnosis, speculate whether this patient may represent a unique form of hypothyroid myopathy, and report the 6-month follow-up of the patient both clinically and electrophysiologically.
authors.affiliation: Ondokuzmayis University, Faculty of Medicine, Department of Neurology, and Gazi State Hospital, Department of Internal Medicine, Samsun, Turkey. handet@omu.edu.tr
authors.forename: Hande
authors.initials: H
authors.lastname: Turker
authors.forename: Oytun
authors.initials: O
authors.lastname: Bayrak
authors.forename: Levent
authors.initials: L
authors.lastname: Gungor
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Murat
authors.initials: M
authors.lastname: Terzi
authors.forename: Cuneyt M
authors.initials: CM
authors.lastname: Turker
authors.forename: Musa K
authors.initials: MK
authors.lastname: Onar
authors.forename: Hakki
authors.initials: H
authors.lastname: Kahraman
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D003937:Diagnosis, Differential; D004576:Electromyography; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D018908:Muscle Weakness; D009133:Muscular Atrophy / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D009431:Neural Conduction; D013577:Syndrome; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones