Cytotoxic xanthones from Garcinia penangiana Pierre.
Two new xanthones, characterized as 4-(1,1-dimethylprop-2-enyl)-1,3,5,8-tetrahydroxyxanthone (1) and penangianaxanthone (2), with three known xanthones, cudratricusxanthone H (3), macluraxanthone C (4) and gerontoxanthone C (5), as well as friedelin and stigmasterol were isolated from the leaves of Garcinia penangiana. Their structures were elucidated by analysis of spectroscopic data and comparison of the NMR data with the literature ones. Significant cytotoxicity against DU-145, MCF-7 and NCI-H460 cancer cell lines was demonstrated by compounds 1-5, with IC50 values ranging from 3.5 to 72.8 microM.
Jabit
Md Lip
ML
Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Khalid
Rozida
R
Abas
Faridah
F
Shaari
Khozirah
K
Hui
Lim Siang
LS
Stanslas
Johnson
J
Lajis
Nordin H
NH
D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D044004:Xanthones / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity*
D044004:Xanthones