Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.
To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
Blanton
Ronald E
RE
Center for Global Health and Diseases, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA. reb6@case.edu
Silva
Luciano K
LK
Morato
Vanessa G
VG
Parrado
Antonio R
AR
Dias
Juarez P
JP
Melo
Paulo R S
PR
Reis
Eliana A G
EA
Goddard
Katrina A B
KA
Nunes
Márcio R T
MR
Rodrigues
Sueli G
SG
Vasconcelos
Pedro F C
PF
Castro
Jesuina M
JM
Reis
Mitermayer G
MG
Barreto
Maurício L
ML
Teixeira
M Glória
MG
D044383:Black People / Q000235:genetics; D001938:Brazil; D003715:Dengue / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007182:Income