title: [Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method].
abstract: OBJECTIVE
  To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata.
  
  
  METHODS
  An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets.
  
  
  RESULTS
  The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets.
  
  
  CONCLUSIONS
  It can enhance the bioavailability of PF by made it to pellets.
authors.affiliation: Jiangsu Academy of Chinese Medicine Sciences, Jiangsu Engineering and Technology Research Center for Modern Chinese Pharmaceutical Preparation, Nanjing 210028, China.
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Yin
authors.initials: Y
authors.lastname: Cai
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Cheng
authors.forename: Chen-yi
authors.initials: CY
authors.lastname: Fan
authors.forename: Ya-fang
authors.initials: YF
authors.lastname: Shi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D007529:Isoflavones / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008863:Microspheres; D018517:Plant Roots / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D007529:Isoflavones; D013607:Tablets; C511199:yufengningxin