title: hSNF5 /INI1 mutation analysis in acute myeloid leukemia.
abstract: Previous studies indicated that region 11.2 of the long arm of chromosome 22 (22q11.2) might be a locus encoding a tumor suppressor gene, since its deletion is a recurrent genetic characteristic of aggressive pediatric cancer. This region is found in the human immunodeficiency virus integrase interactor 1 (hSNF5/INI1) gene. To investigate whether the hSNF5/INI1 gene is involved in leukemogenesis, mutation analysis of the hSNF5/INI1 gene was performed in the present study using 5 hematopoietic cell lines, acute myeloid leukemia (AML) specimen and normal control. We found two single nucleotide polymorphisms at the hSNF5/INI1 gene in exon 4 and exon 9. The results of this study suggest that the hSNF5/INI1 gene does not play an important role in the leukemogenesis of AML.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin TzuChi General Hospital, No. 2, Ming-Shen Road, Chiayi County, Taiwan. hepatoma@ms3.hinet.net.
authors.forename: Yu-Chieh
authors.initials: YC
authors.lastname: Su
authors.affiliation: Department of Chemical Engineering, National Chung Cheng University, Chiayi, Taiwan.
authors.forename: Chao-Bin
authors.initials: CB
authors.lastname: Chen
authors.affiliation: Department of Chemical Engineering, National Chung Cheng University, Chiayi, Taiwan.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Chang
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin TzuChi General Hospital, No. 2, Ming-Shen Road, Chiayi County, Taiwan.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Tung
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin TzuChi General Hospital, No. 2, Ming-Shen Road, Chiayi County, Taiwan.
authors.forename: Dian-Kun
authors.initials: DK
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D045744:Cell Line, Tumor; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000071796:SMARCB1 Protein; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors