Pregnancy-associated liver disorders.
Liver disorders associated with pregnancy include hyperemesis gravidarum (HG), intrahepatic cholestasis of pregnancy (ICP), preeclampsia, syndrome of hemolysis, elevated liver enzymes and low platelets (HELLP), and acute fatty liver of pregnancy (AFLP). These conditions are relatively common and unique to pregnancy and are more likely to occur at certain terms of gestation specific to each condition. They can be associated with significant maternal and fetal morbidity and mortality. Although managing such patients may be very challenging, spontaneous resolution of the disease occurs shortly after termination of the pregnancy, usually without hepatic sequellae. Early diagnosis and timely treatment is a key to therapeutic success. This article explores the clinical features, pathophysiology, and management of these disorders.
Hepburn
Iryna S
IS
Department of Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. ihepburn@mail.mcg.edu
Schade
Robert R
RR
D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D008107:Liver Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*