[A case of dihydropyrimidine dehydrogenase (DPD) deficiency with severe side effects from UFT/Uzel administration].
5-FU is among the drugs most frequently used in the treatment of gastrointestinal malignancies. Also, it has been reported to reveal severe side effects in the case of a dihydropyrimidine dehydrogenase (DPD) deficiency. A 75-year-old man showed severe nausea and vomiting after administration of UFT/Uzel as adjuvant chemotherapy. Because of severe thrombocytopenia and grade 4 neutropenia, platelet transfusion and G-CSF administration were performed. With time, the leukocyte, neutrophil and platelet count recovered to normal level. We strongly suspected a DPD deficiency from the result of urinary pyrimidine analysis.
Kai
Kyohei
K
Dept. of Surgery, Himeji Red Cross Hospital.
Endo
Yoshikatsu
Y
Yoshida
Kazuhiro
K
Morikawa
Tatsuya
T
Nobuhisa
Tetsuji
T
Watanabe
Takayuki
T
Matsumoto
Yusuke
Y
Yamada
Takatoshi
T
Doi
Yoshinori
Y
Nakashima
Akira
A
Nagahiro
Wataru
W
Ishizuka
Shinji
S
Sato
Shizou
S
Nakashima
Akira
A
Nabeyama
Akira
A
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D054067:Dihydropyrimidine Dehydrogenase Deficiency; D050744:Dihydrouracil Dehydrogenase (NAD+) / Q000172:deficiency* / Q000378:metabolism*; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000378:metabolism*; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014498:Uracil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D005641:Tegafur; D014498:Uracil; D050744:Dihydrouracil Dehydrogenase (NAD+); D042943:Dihydrouracil Dehydrogenase (NADP)