Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation.
PGP peptide had a protective effect in contractile dysfunction of the rat mesenteric lymph vessels under conditions of inflammation, irrespective of the time of its injection (before or after inflammatory agent). The preventive effect of this peptide is largely determined by its capacity to prevent mast cells activation. PGP injected 2 h after induction of inflammation did not inhibit secretory activity of mast cells, which suggests other mechanisms of its therapeutic action.
Umarova
B A
BA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. bellaum@mail.ru.
Kopylova
G N
GN
Lelekova
T V
TV
Bakaeva
Z V
ZV
Goncharova
E L
EL
Samonina
G E
GE
D000818:Animals; D042601:Lymphatic Vessels / Q000187:drug effects / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D008643:Mesentery / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D010538:Peritonitis / Q000139:chemically induced / Q000503:physiopathology*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013864:Thioglycolates
D009842:Oligopeptides; D013864:Thioglycolates; C113164:prolyl-glycyl-proline; D011392:Proline; D009638:Norepinephrine