A case of late-onset severe cardiotoxicity from 5-fluorouracil therapy resulting in death.
This case highlights the possibility of late-onset severe cardiotoxicity resulting in sudden cardiac death from 5-fluorouracil (5-FU) therapy. Late-onset cardiotoxicity of 5-FU, after initial tolerance, has not been reported before.
Wijesinghe
Namal
N
Department of Cardiology, Waikato Hospital, Private Bag 3200, Hamilton. namalw@gmail.com
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives; D003110:Colonic Neoplasms / Q000188:drug therapy*; D017809:Fatal Outcome; D005472:Fluorouracil / Q000009:adverse effects*; D006323:Heart Arrest / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D002955:Leucovorin / Q000009:adverse effects; D008297:Male
D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin