Epigenetic modulation and cancer: effect of metabolic syndrome?
The importance of epigenetics in the etiology of disease, including cancer development and progression, is increasingly being recognized. However, the relevance of epigenetics to the metabolic syndrome, and how it may affect cancer, is only beginning to capture the interest of the scientific community. This review focuses on data supporting the hypothesis that, in addition to the "thrifty genotype" and "thrifty phenotype" hypotheses, diet-induced changes in "epigenetic programming" during fetal and postnatal development may precipitate the metabolic syndrome. Thus, epigenetics may bridge both the thrifty genotype and thrifty phenotype hypotheses and provide a link between genes and the environment concerning disease predisposition to metabolic syndrome and its associated diseases.
Ross
Sharon A
SA
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7328, USA. rossha@mail.nih.gov
Milner
John A
JA
D019175:DNA Methylation; D004032:Diet; D004777:Environment; D044127:Epigenesis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics*; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D010641:Phenotype; D011247:Pregnancy