The thuggacins, novel antibacterial macrolides from Sorangium cellulosum acting against selected Gram-positive bacteria.
In our screening program we found an activity against some Gram-positive bacteria, including mycobacteria in the culture supernatant of Sorangium cellulosum strain So ce895. The antibiotic responsible for this activity was isolated and named thuggacin. Initial studies towards the mechanism of action showed that thuggacin A inhibits a late step of the respiratory chain of some bacteria.
Irschik
Herbert
H
Research Group Microbial Drugs, Germany. herbert.irschik@helmholtz-hzi.de
Reichenbach
Hans
H
Höfle
Gerhard
G
Jansen
Rolf
R
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D003580:Cytochromes / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D009231:Myxococcales / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D013941:Thymine / Q000096:biosynthesis; D014498:Uracil / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D001426:Bacterial Proteins; D003580:Cytochromes; D018942:Macrolides; C523035:thuggacin A; C523034:thuggacin B; C523033:thuggacin C; D009243:NAD; D014498:Uracil; D013941:Thymine; D010100:Oxygen