title: Randomised crossover trial of different postural interventions on bradycardia and intermittent hypoxia in preterm infants.
abstract: BACKGROUND
  Apnoea of prematurity has been shown to respond to changes in posture.
  
  
  OBJECTIVE
  To investigate the effect of three postural interventions on the rate of bradycardia and desaturation events.
  
  
  METHODS
  18 infants (< or =32 weeks' gestational age; 11 boys) with apnoea of prematurity underwent recordings of breathing movements, electrocardiogram and instantaneous heart rate, pulse oximeter saturation (SpO2), photoplethysmographic waveforms and digital video frame while in one of three different prone positions. The following interventions were applied in random order: horizontal position (HP), 15 degrees head-up tilt position (TP) and three-level position (3P) according to Kinaesthetics Infant Handling. The primary study variable was the combined event rate of desaturations (SpO2 <85%) and bradycardias (heart rate <80 bpm). One secondary study variable was the duration of body movements.
  
  
  RESULTS
  The median (range) combined event rate was 26.7/h (0.3-72.7) in HP, 25.2/h (0.3-70.5) in TP and 21.2/h (0-66.3) in 3P (p>0.05). The median (range) duration of body movements was 10.8 s/h (0-48.2) in HP, 7.1 s/h (0-72.4) in TP and 7.0 s/h (0-47.7) in 3P (p>0.05).
  
  
  CONCLUSIONS
  No significant advantage of a head-up tilt or a three-level position over a standard horizontal position could be confirmed.
authors.affiliation: Department of Neonatology, University Children's Hospital, Tuebingen, Germany. christian-f.poets@med.uni-tuebingen.de
authors.forename: C
authors.initials: C
authors.lastname: Reher
authors.forename: K D
authors.initials: KD
authors.lastname: Kuny
authors.forename: T
authors.initials: T
authors.lastname: Pantalitschka
authors.forename: M S
authors.initials: MS
authors.lastname: Urschitz
authors.forename: C F
authors.initials: CF
authors.lastname: Poets
mesh_terms: D001919:Bradycardia / Q000517:prevention & control*; D018592:Cross-Over Studies; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000451:nursing*; D008297:Male; D010092:Oximetry; D010101:Oxygen Consumption / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D016684:Prone Position