Thyroid hormone regulation of heart metabolism.
Thyroid hormone regulates cardiac metabolism through multiple mechanisms. Traditionally, most cardiac metabolic studies have focused on presumed transcriptional actions by defining thyroid hormone-induced changes in mRNA or protein levels. Recent studies have established metabolic pathways in heart that rapidly respond to thyroid hormone. Functions have also been implicated for thyroid hormone receptors, which are separate from their transcriptional actions. Finally, thyroid through ligand binding may play a direct role in transactivation of mitochondrial DNA. This review will explore these newly identified modes of thyroid action on metabolism in heart.
Portman
Michael A
MA
Department of Cardiology, Children's Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA. michael.portman@seattlechildrens.org
D000818:Animals; D004734:Energy Metabolism / Q000235:genetics; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D014284:Triiodothyronine / Q000378:metabolism
D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones; D014284:Triiodothyronine