The poly(ADP-ribosylation) story: a long route from Cinderella to Princess.
Poly(ADP-ribosylation) is a post-translational modification of proteins with a multifunctional role in basic processes, such as DNA repair, transcription, cell proliferation and death. For decades, this reaction was studied by a small community of researchers, devoted to the identification of signals promoting the conversion of the coenzyme NAD into poly(ADP-ribose) and the further degradation of the polymers. The development of specific inhibitors and the discovery of a superfamily of poly(ADP-ribosylating) enzymes have recently conferred a higher importance to this process. The main features of poly(ADP-ribosylation) together with new research perspectives will be discussed.
Scovassi
A Ivana
AI
Istituto di Genetica Molecolare CNR, Pavia, Italy. scovassi@igm.cnr.it
D000818:Animals; D017209:Apoptosis; D035843:Biomedical Research; D004260:DNA Repair; D004330:Drosophila / Q000235:genetics; D005544:Forecasting; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000201:enzymology; D009154:Mutation; D009243:NAD / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D016615:Telomere / Q000187:drug effects
D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D009243:NAD; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase