title: Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.
abstract: Like their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response--called the UV response--that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"--signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.
authors.affiliation: Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany. herrlich@fli-leibniz.de
authors.forename: Peter
authors.initials: P
authors.lastname: Herrlich
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
authors.forename: Carsten
authors.initials: C
authors.lastname: Weiss
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000528:radiation effects; D005544:Forecasting; D008027:Light; D008322:Mammals; D008954:Models, Biological; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology* / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D011506:Proteins