Clinicopathological and genetic characteristics in Chinese patients with lipoprotein glomerulopathy.
OBJECTIVE
In this study, we report on 16 Chinese patients with biopsy-proven lipoprotein glomerulopathy (LPG) investigated for clinical manifestations, pathological characteristics and apolipoprotein E (apoE) genetic analysis.


METHODS
A retrospective analysis of the clinical and pathological features was made in 16 patients with LPG. Plasma concentrations and genetic analysis of apoE were completed. Glomerular depositions of apoA, apoB and apoE were detected using monoclonal antibodies on cryostatic sections in all patients.


RESULTS
All 16 patients presented with edema; 14 presented with nephrotic syndrome. Anemia, microhematuria, hypertension and abnormal levels of serum creatinine were detected in 12 patients (75%), 11 patients (69%), 8 patients (50%) and 6 patients (37.5%), respectively. All the patients showed hypertriglyceridemia, while only 7 showed slight hypercholesterolemia. The characteristic features of hyperlipidemia in these patients were approximately in accord with those of type IV hyperlipoproteinemia. Concentrations of apoB correlated with urine protein, triglycerides and cholesterol (r=0.558, p=0.038; r=0.6, p=0.023; r=0.65, p=0.012; respectively). No correlation was found between serum level of apoE and clinicopathological features in patients with LPG. The genotype of apoE-epsilon3/epsilon4 is the predominant one in Chinese patients with LPG. No mutated forms of apoE were found, compared with previous reports.


CONCLUSIONS
Unique clinicopathological and genetic features were found in this group of Chinese patients with LPG compared with the general population, including lower serum levels of apoE and cholesterol, as well as anemia and microhematuria. Multiple factors other than apoE were involved in the pathogenesis of LPG.
Zhang
Bo
B
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002 [corrected] China. zhihong@public1.ptt.js.cn [corrected]
Liu
Zhi-Hong
ZH
Zeng
Cai-Hong
CH
Zheng
Jing-Min
JM
Chen
Hui-Ping
HP
Li
Lei-Shi
LS
D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011973:Receptors, LDL / Q000378:metabolism
D001057:Apolipoproteins E; D008074:Lipoproteins; D011973:Receptors, LDL