title: Low serum and peritoneal fluid concentration of interferon-gamma-induced protein-10 (CXCL10) in women with endometriosis.
abstract: OBJECTIVE
  To evaluate serum and peritoneal fluid concentrations of interferon-gamma-inducible protein-10 (CXCL10), a chemokine involved in local immune function, in women with endometriosis.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Division of Obstetrics and Gynecology, University of Siena.
  
  
  METHODS
  A total of 147 women were divided in two groups: women with (n = 77) and without (n = 70) endometriosis.
  
  
  METHODS
  Serum and peritoneal fluid were collected from all patients undergoing laparoscopy.
  
  
  METHODS
  CXCL10 concentrations were measured by a specific ELISA.
  
  
  RESULTS
  Serum CXCL10 concentrations in women with endometriosis were significantly lower than in those without endometriosis. No statistically significant difference between women with early endometriosis and those with advanced endometriosis was found. CXCL10 concentrations in peritoneal fluid of women with advanced endometriosis were significantly lower than in that of women with an early stage of, or without, endometriosis.
  
  
  CONCLUSIONS
  The decreased concentrations of CXCL10 in serum and peritoneal fluid of women with endometriosis indicate an impaired immune activity in women with endometriosis.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Pediatrics, Gynecology and Reproductive Medicine, University of Siena, Siena, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Galleri
authors.forename: Stefano
authors.initials: S
authors.lastname: Luisi
authors.forename: Mario
authors.initials: M
authors.lastname: Rotondi
authors.forename: Paola
authors.initials: P
authors.lastname: Romagnani
authors.forename: Luigi
authors.initials: L
authors.lastname: Cobellis
authors.forename: Mario
authors.initials: M
authors.lastname: Serio
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
mesh_terms: D001202:Ascitic Fluid / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000032:analysis* / Q000097:blood; D015536:Down-Regulation; D004715:Endometriosis / Q000276:immunology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D010535:Laparoscopy; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10