A dynamic t-SNARE complex.
Syntaxin-1/SNAP-25 heterodimers with 1:1 stoichiometry likely play a key role in neurotransmitter release but they have been difficult to characterize. In this issue of Structure, Weninger et al. present a beautiful single molecule spectroscopy study showing the dynamic nature of these heterodimers and how they are influenced by other factors.
Rizo
Josep
J
D019281:Dimerization; D031541:Fluorescence Resonance Energy Transfer; D050600:SNARE Proteins / Q000378:metabolism; D050825:Synaptosomal-Associated Protein 25 / Q000737:chemistry* / Q000378:metabolism; D050827:Syntaxin 1 / Q000737:chemistry* / Q000378:metabolism
D050600:SNARE Proteins; D050825:Synaptosomal-Associated Protein 25; D050827:Syntaxin 1