title: Histoplasmosis of the larynx.
abstract: The incidence of laryngeal histoplasmosis is low when compared to the total number of cases. Less than 100 cases of laryngeal histoplasmosis have been described in the medical literature. Isolated laryngeal involvement may lead to the misdiagnosis and mistreatment of tuberculosis or laryngeal cancer, according to some reports. The development of hoarseness in a patient with histoplasmosis or a laryngeal mass leading to hoarseness, might be suggestive of laryngeal histoplasmosis. When histoplasmosis is included among the differential diagnoses of a laryngeal lesion, the biopsy should be limited to a small tissue fragment, enough to perform histological tests. The laboratory technicians must be warned about the possibility of histoplasmosis, because special dyes have to be used to confirm this diagnosis.
authors.affiliation: M.S student in Otolaryngology, MD. Assistant Physician of the Otolaryngology Service Hospital Nossa Senhora de Lourdes. Electronic address: fernandopochini@uol.com.br.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pochini Sobrinho
authors.affiliation: PhD. Professor, Head of the 2nd inpatient unit of the Emílio Ribas Infectology Institute.
authors.forename: Marinella
authors.initials: M
authors.lastname: Della Negra
authors.affiliation: M.S. in Infectology. Assistant Physician - 2nd inpatient unit of the Emílio Ribas Infectology Institute.
authors.forename: Wladimir
authors.initials: W
authors.lastname: Queiroz
authors.affiliation: Otolaryngologist, Head of the Otolaryngology Service - Hospital Nossa Senhora de Lourdes.
authors.forename: Ulisses
authors.initials: U
authors.lastname: José Ribeiro
authors.affiliation: Otolaryngologist, Head of the Otolaryngology Service - Hospital Nossa Senhora de Lourdes.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Bittencourt
authors.affiliation: M.S. in Health Sciences. Assistant Physician - 2nd inpatient unit of the Emílio Ribas Infectology Institute.
authors.forename: Giselle
authors.initials: G
authors.lastname: Burlamaqui Klautau
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D015725:Fluconazole / Q000627:therapeutic use; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D007828:Laryngoscopy; D008297:Male
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole