title: Sudden death due to aortic rupture in acromegaly.
abstract: Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem examination disclosed, nearby the point of rupture, a pulmonary abscess as well as extensive intrinsic alteration of arteries originating from the aortic arch and aorta itself, which featured microscopic cystic medial necrosis. We discussed how these aspects could be related to long-term exposition to growth hormone excess. In particular, this case gives further evidence of vascular system frailty in acromegaly.
authors.affiliation: Department of Medical and Surgical Sciences, Clinica Medica 3, University School of Medicine, Via Giustiniani 2, 35100 Padua, Italy. pietromaffei@libero.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Maffei
authors.forename: Carla
authors.initials: C
authors.lastname: Menegazzo
authors.forename: Mauro
authors.initials: M
authors.lastname: Michelotto
authors.forename: Roberto
authors.initials: R
authors.lastname: Salmaso
authors.forename: Chiara
authors.initials: C
authors.lastname: Martini
authors.forename: Eugenio
authors.initials: E
authors.lastname: De Carlo
authors.forename: Marta
authors.initials: M
authors.lastname: Carli
authors.forename: Martina
authors.initials: M
authors.lastname: Barban
authors.forename: Ambrogio
authors.initials: A
authors.lastname: Fassina
authors.forename: Roberto
authors.initials: R
authors.lastname: Vettor
authors.forename: Nicola
authors.initials: N
authors.lastname: Sicolo
mesh_terms: D000172:Acromegaly / Q000150:complications*; D017545:Aortic Aneurysm, Thoracic / Q000150:complications* / Q000175:diagnosis; D001019:Aortic Rupture / Q000150:complications* / Q000175:diagnosis; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D013902:Radiography, Thoracic; D012307:Risk Factors