title: HIV type 2 intergroup recombinant identified in Cameroon.
abstract: A unique HIV-2 intergroup recombinant strain was identified in Cameroon. The virus, CM-03-510-03, was amplified from blood collected from a 47-year-old female patient in Douala, Cameroon in 2003 who was seroreactive for HIV-2. A near full-length genome 9089 nucleotides in length was amplified from proviral DNA. The genome for CM-03-510-03 is composed of segments of HIV-2 groups A and B with four recombination break-points and has open reading frames for all the structural and regulatory genes. A comparison of CM-03-510-03 to the only previously reported HIV-2 intergroup recombinant shows that the two strains share one recombination breakpoint but are otherwise distinct from each other. Similar to HIV-1, HIV-2 intergroup recombination is an indication that coinfection with more than one strain has occurred in individuals and is a mechanism that increases strain genetic diversity.
authors.affiliation: Abbott Diagnostics, Abbott Park, Illinois 60064, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Yamaguchi
authors.forename: Ana
authors.initials: A
authors.lastname: Vallari
authors.forename: Nicaise
authors.initials: N
authors.lastname: Ndembi
authors.forename: Ruthie
authors.initials: R
authors.lastname: Coffey
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ngansop
authors.forename: Dora
authors.initials: D
authors.lastname: Mbanya
authors.forename: Lazare
authors.initials: L
authors.lastname: Kaptué
authors.forename: Lutz G
authors.initials: LG
authors.lastname: Gürtler
authors.forename: Sushil G
authors.initials: SG
authors.lastname: Devare
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Brennan
mesh_terms: D002163:Cameroon; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015498:HIV-2 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D054298:Human Immunodeficiency Virus Proteins / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D011533:Proviruses / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral; D054298:Human Immunodeficiency Virus Proteins; D012367:RNA, Viral