[The difference in some clinical and pathological characteristics between chronic sinusitis patients with and without nasal polyps].
OBJECTIVE
To explore the difference in some subjective symptoms, objective examination results, and pathological characteristics between chronic sinusitis patients with and without nasal polyps (CRSwNP and CRSsNP).


METHODS
Prospective data of 42 CRSsNP patients and 33 CRSwNP patients scheduled for surgery were collected and analyzed retrospectively. A visual analog scale (VAS) symptom score was completed. The preoperative computed tomography (CT) scans were graded according to Lund and Mackay. The preoperative nasal endoscopy was graded by assigning an endoscopy score according to Lanza and Kennedy. Blood was drawn to determine the number of peripheral eosinophils (EOS) by means of automated analysis. Surgical specimen was examined pathologically for the number of EOS per high-powered field. Interleukin (IL)-5 was determined by means of quantitative enzyme-linked immunosorbent assay.


RESULTS
(1) As to the single VAS symptom score relating to overall symptom severity and the VAS score based on the sum of five sinonasal symptoms, there was no difference between CRSsNP and CRSwNP patients (P > 0.05). However, compared with CRSwNP patients, CRSsNP patients had higher VAS score of nasal discharge (P < 0.05) and lower score of hyposmia (P < 0.01); (2) Compared with CRSsNP patients, CRSwNP patients had higher CT and endoscopy scores, peripheral and mucosal EOS counts, and mucosal IL-5 level (P < 0.05); (3) The preoperative CT and endoscopy scores were positively correlated with peripheral and mucosal EOS counts and mucosal IL-5 level (P < 0.01).


CONCLUSIONS
There is no significant difference in overall symptom between CRSsNP and CRSwNP patients. However, CRSwNP patients have more severe inflammation in nasal and sinus cavity, which is related to eosinophilic inflammation in local mucosa.
Liu
Zheng
Z
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. zhengliuent@hotmail.com
Lu
Xiang
X
Wang
Heng
H
You
Xuejun
X
Gao
Qixue
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D004724:Endoscopy; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000473:pathology; D012189:Retrospective Studies; D012852:Sinusitis / Q000150:complications / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D055815:Young Adult