title: Assembling the pieces.
abstract: Transition metals function as cofactors in specific proteins, catalyzing electron exchange reactions, binding substrates and stabilizing protein structure. Studies of human diseases and of model organisms have defined many of the molecular details of metal uptake, trafficking, and excretion. The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Research Drive, LSRC C351, Durham, North Carolina 27710, USA. dennis.thiele@duke.edu
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Thiele
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Gitlin
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism; D002384:Catalysis; D002462:Cell Membrane / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology / Q000639:trends; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000235:genetics; D008667:Metalloproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D049490:Systems Biology / Q000639:trends; D014054:Tomography / Q000295:instrumentation / Q000639:trends; D028561:Transition Elements / Q000737:chemistry / Q000378:metabolism; D015027:Zebrafish
chemical_list: D008667:Metalloproteins; D028561:Transition Elements