title: [Effect of treatment with amiodarone on sinus node function].
abstract: Treatment with amiodarone is often associated with sinus bradycardia. We studied 477 patients (mean age 48.7 +/- 0.7 years) with various cardiac rhythm disturbances. Most patients had ischemic heart disease. Average saturation dose of amiodarone was 809.4 +/- 13.4 mg/day, average maintenance dose - 263.2 +/- 5.4 mg/day, average duration of follow-up - 20.85 +/- 1.2 months. Regular Holter ECG monitoring was used for detection of sinus bradycardia (heart rate less than 60/min). Sinus bradycardia was registered in 32 and 11.2% of patients during saturation with amiodarone and maintenance treatment, respectively. Bradycardia usually improved after lowering of amiodarone dose. Heart rate slowing was not pronounced and required neither cessation of amiodarone administration nor electrical cardiac pacing.
authors.forename: D I
authors.initials: DI
authors.lastname: Reĭngardene
mesh_terms: D000284:Administration, Oral; D000638:Amiodarone / Q000008:administration & dosage* / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D004334:Drug Administration Schedule; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012849:Sinoatrial Node / Q000187:drug effects*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone