title: Reduced respiratory and skeletal muscle strength in survivors of sibling or unrelated donor hematopoietic stem cell transplantation.
abstract: We performed a retrospective analysis of muscle strength testing obtained following sibling or unrelated donor hematopoietic stem cell transplant (HSCT) between 1 January 1999 and 31 December 2003 in a cohort of 44 subjects at Tufts-New England Medical Center. Maximal inspiratory pressure (PI(max)) was <or=80% predicted in 52% of subjects and <or=60% predicted in 20% of subjects; maximal expiratory pressure (PE(max)) was <or=80% predicted in 88% of subjects and <or=60% predicted in 74% of subjects. Patients with a PI(max) <or=60% predicted spent significantly longer time in hospital following HSCT compared with subjects with PI(max) 60% predicted. Grip strength (n=32) was reduced to <or=80% predicted in 75% of subjects and <or=60% predicted in 47% of subjects following HSCT. Analysis of paired measurements obtained before and after HSCT in 20 of the 44 subjects (45%) showed significant reduction in both PI(max) and PE(max) between the two measures. Respiratory and skeletal muscle weakness is present in a significant percentage of subjects undergoing pulmonary function testing in the post-HSCT period, and may contribute to pulmonary morbidity in subjects with pulmonary complications of HSCT.
authors.affiliation: Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kovalszki
authors.forename: G L
authors.initials: GL
authors.lastname: Schumaker
authors.forename: A
authors.initials: A
authors.lastname: Klein
authors.forename: N
authors.initials: N
authors.lastname: Terrin
authors.forename: A C
authors.initials: AC
authors.lastname: White
mesh_terms: D000328:Adult; D017079:Exercise Tolerance; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000503:physiopathology*; D012189:Retrospective Studies; D014184:Transplantation, Homologous / Q000009:adverse effects*