Prevalence of the BCR/ABL1 transcripts in Mexican patients with chronic myelogenous leukemia.
RT-PCR studies in 93 patients with chronic myelogenous leukemia from the Mexican West were done in order to know the proportion of b2a2 and b3a2 BCR/ABL1 transcripts. Forty-five patients showed the b3a2 transcript (48%), 37 (40%) displayed the b2a2 and in 11 cases (12%) both transcripts were detected. Statistical analyses showed that these figures are in accordance with two of three similar studies realized in Mexican population. Moreover, significant differences were found among Mexican people and patients from other countries, namely Ecuador, England, Italy, Poland, Japan, and Thailand. Ecuadorian patients showed differences with all the populations analyzed. These variations could be due to a different genetic background.
Meza-Espinoza
Juan Pablo
JP
Facultad de Medicina, Unidad Académica de Ciencias de la Salud y Tecnología, Universidad Autónoma de Tamaulipas.
Gutiérrez-Angulo
Melva
M
Vázquez-Cárdenas
Alejandra
A
Delgado-Lamas
José Luis
JL
Esparza-Flores
María Amparo
MA
González-García
Juan Ramón
JR
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014158:Transcription, Genetic
C406060:abl-bcr fusion protein, human; D016044:Fusion Proteins, bcr-abl