title: Biopsy-proven adenoviral diarrhea responding to low-dose cidofovir.
abstract: We present a case of diarrhea secondary to biopsy-proven adenovirus (ADV) infection after autologous peripheral hematopoietic stem cell transplant for multiple myeloma. The patient had a negative plasma polymerase chain reaction for ADV and a dramatic clinical response to low-dose cidofovir. To our knowledge, this is the first report in an adult hematopoietic stem cell recipient of the use of low-dose cidofovir to treat proven ADV gastrointestinal infection.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Nicolasora
authors.forename: P
authors.initials: P
authors.lastname: Reddy
authors.forename: D R
authors.initials: DR
authors.lastname: Kaul
mesh_terms: D000256:Adenoviridae / Q000276:immunology / Q000302:isolation & purification; D000258:Adenovirus Infections, Human / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000368:Aged; D000956:Antigens, Viral / Q000302:isolation & purification; D000998:Antiviral Agents / Q000627:therapeutic use*; D001706:Biopsy; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D003967:Diarrhea / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D004334:Drug Administration Schedule; D005243:Feces / Q000821:virology; D005753:Gastric Mucosa / Q000473:pathology / Q000821:virology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D007181:Inclusion Bodies, Viral; D045586:Intranuclear Inclusion Bodies; D008297:Male; D009101:Multiple Myeloma / Q000601:surgery; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D063065:Organophosphonates; D013792:Thalidomide; D003907:Dexamethasone; D003596:Cytosine; D000077404:Cidofovir