Base excision DNA repair.
DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc. Individual enzymes acting in base excision repair have been identified. The recent years were marked with many advances in understanding of their structure and many interactions that make base excision repair a functional, versatile system. This review describes the current knowledge of structural biology and biochemistry of individual steps of base excision repair, several subpathways of the common base excision repair pathway, and interactions of the repair process with other cellular processes.
Zharkov
D O
DO
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. dzharkov@niboch.nsc.ru
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage / Q000502:physiology; D045647:DNA Glycosylases / Q000502:physiology; D004260:DNA Repair / Q000502:physiology*; D045643:DNA Repair Enzymes / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D015321:Gene Rearrangement / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D008954:Models, Biological; D008958:Models, Molecular; D034521:Nuclear Matrix-Associated Proteins / Q000502:physiology; D063245:Plant Development; D010944:Plants / Q000235:genetics; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000502:physiology; D018406:Virus Physiological Phenomena; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D007136:Immunoglobulins; D034521:Nuclear Matrix-Associated Proteins; D018809:Proliferating Cell Nuclear Antigen; D000076105:X-ray Repair Cross Complementing Protein 1; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases; D045647:DNA Glycosylases; D045643:DNA Repair Enzymes