Late onset of a facial variant of steatocystoma multiplex - calretinin as a specific marker of the follicular companion cell layer.
Steatocystoma multiplex is a rare,almost exclusively autosomal dominant disease of the sebaceous glands. The sites of predilection are the sternal region, upper back, axillae and proximal parts of the extremities. A 78-year-old woman developed multiple yellowish nodules only on the face over a few months. Histology revealed large cysts with a thin wall and connection to sebaceous glands. Immunohistochemical analysis showed the inner epithelial layer of the cysts was positive with calretinin.With curettage and CO2 laser therapy, a good cosmetic result was achieved.This is the first case report in the German literature of a rare sporadic form of steatocystoma multiplex with late onset and exclusive localization in the face.
Riedel
Christian
C
Department of Dermatology, Clinic of Dortmund gGmbH, Beurhausstrasse, Germany. christian.riedel@klinikumdo.de
Brinkmeier
Thomas
T
Kutzne
Heinz
H
Plewig
Gerd
G
Frosch
Peter J
PJ
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D064032:Calbindin 2; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D018859:Hair Follicle / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D035583:Rare Diseases / Q000175:diagnosis / Q000628:therapy; D064030:S100 Calcium Binding Protein G / Q000032:analysis*; D012625:Sebaceous Gland Diseases / Q000175:diagnosis* / Q000628:therapy
D015415:Biomarkers; C576764:CALB2 protein, human; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G