title: Association study of the GAB2 gene with the risk of developing Alzheimer's disease.
abstract: The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE varepsilon4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT+TT)=1.3, 95% CI 1.0-1.6, p=0.09) and the G allele frequency (OR=1.3, 95%CI 1.0-1.6, p=0.05) in varepsilon4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD.
authors.affiliation: INSERM,U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Chapuis
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.forename: Peter
authors.initials: P
authors.lastname: Bentham
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.forename: Isabelle
authors.initials: I
authors.lastname: Leber
authors.forename: Thierry
authors.initials: T
authors.lastname: Frebourg
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Deleuze
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Cousin
authors.forename: Uma
authors.initials: U
authors.lastname: Thaker
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: David
authors.initials: D
authors.lastname: Mann
authors.forename: Corinne
authors.initials: C
authors.lastname: Lendon
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D053327:Apolipoprotein E4 / Q000235:genetics; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003431:Cross-Cultural Comparison; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D053327:Apolipoprotein E4; C490895:GAB2 protein, human