Incorporation by host tissue of two biomaterials used as repair of defects produced in abdominal wall of rats.
OBJECTIVE
Biomaterials may be used as treatment of great abdominal wall defects to avoid tension during repair. In the present research we intended to investigate incorporation type by host tissue of membranes of microbial cellulose (MC), produced by the bacteria Zoogloea sp., and of polytetrafluoroethylene (ePTFE) in abdominal wall defects of rats.


METHODS
Sixty male rats Wistar, anesthetized by ketamine (5mg/100g) and xylazine (2mg/100g), were submitted to a rectangular excision (2 x 3cm) of the abdominal wall, including fascia, muscles and peritoneum and further treated with implants of microbial cellulose (MC Group - 30 animals) or expanded polytetrafluoroethylene ( ePTFE Group- 30 animals). Each group was subdivided in 14th DPO, 28th DPO and 60th DPO Subgroups.


RESULTS
Incorporation of biomaterials was observed by wrapping and infiltration by host tissue. It has been found that wrapping associated to infiltration of host connective tissue in implants of ePTFE were present in 100% of the observed samples, and this may be responsible for increase resistance to traction. Inversely, wrapping without host tissue infiltration was seen in 100% of examined specimens of MC implants.


CONCLUSIONS
Wrapping and host tissue infiltration is seen only in ePTFE implants.
Falcão
Suyiene Cordeiro
SC
Department of Veterinary Medicine, Federal Rural University of Pernambuco, Brazil.
Evêncio Neto
Joaquim
J
Coelho
Antônio Roberto de Barros
AR
D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001672:Biocompatible Materials; D002482:Cellulose; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps; D000267:Tissue Adhesions; D014945:Wound Healing / Q000502:physiology*
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D002482:Cellulose