The road to genome-wide association studies.
The recent crop of results from genome-wide association studies might seem like a sudden development. However, this blooming follows a long germination period during which the necessary concepts, resources and techniques were developed and assembled. Here, I look back at how the necessary pieces fell into place, focusing on the less well-chronicled days before the launch of the HapMap project, and speculate about future developments.
Kruglyak
Leonid
L
Lewis-Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA. leonid@genomics.princeton.edu
D016022:Case-Control Studies; D002874:Chromosome Mapping; D014644:Genetic Variation; D015894:Genome, Human; D023281:Genomics / Q000266:history / Q000379:methods* / Q000639:trends; D049671:History, 18th Century; D049673:History, 20th Century; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide