[Discontinued oral ciprofloxacin for transurethral resection of the prostate in patients with sterile urine without preoperative bladder catheter].
OBJECTIVE
To describe the rate of infectious complications using discontinuous oral ciprofloxacin in transurethral resection of the prostate. To weigh up the influence of clinical background, surgical complications and postoperative outcome on the development of such complications. To compare the results to those obtained will equal methodology using antibiotics until catheter removal.


METHODS
A prospective open study was designed including 105 consecutive patients with sterile urine and without indwelling catheter subjected to transurethral resection of the prostate. Patients received oral ciprofloxacin 500 mg (4 doses) on call to the surgical room, the night of the surgery, next morning of surgery and before catheter removal.


RESULTS
One hundred patients are analyzed. Fever was present in 10% patients (axillary temperature equal or over 37.5 degrees C). Systemic clinical infection was present in 3% patients (axillary temperature over 38 degrees C and C-reactive protein over 40 mg/l). No isolated postoperative bacteriuria was present (colony count > 10(5) CFU/ ml). Active chronic prostatitis was statistically asociated to fever (p= 0,018) and to systemic clinical infection (p= 0,016). Previous urinary tract infection antecedent was statistically associated to active chronic prostatitis on histopathology (p= 0,049).


CONCLUSIONS
This study shows some clinical evidence supporting that previous urinary tract infection antecedent is a risk factor of infectious complications after transurethral resection of the prostate and that prostate bearing microorganisms may be responsible for some of them in this kind of patients. An antibiotic dose before catheter removal seem to reduce postoperative bacteriuria.
Valdevenito Sepúlveda
Juan Pablo
JP
Servicio de Urología, Hospital Clínico Universidad de Chile, División de Bioestadística, Escuela de Salud Pública, Universidad de Chile, Santiago, Chile. jpvaldevenito@redclinicauchile.cl
Hernández
Enrique
E
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects*; D001743:Urinary Bladder; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control* / Q000652:urine
D000890:Anti-Infective Agents; D002939:Ciprofloxacin