Effects of caffeine and siloxanetriol alginate caffeine, as anticellulite agents, on fatty tissue: histological evaluation.
BACKGROUND
Cellulite is a physiological condition that presents etiologic plurality. Caffeine and its derivatives are used in anticellulite cosmetics due to their lipolytic activity on fatty cells. Siloxanetriol alginate caffeine (SAC) is a silanol derived from organic silicon. Radicals primarily from SAC are caffeine and the mannuronic acid.


OBJECTIVE
This study aims to analyze the effects of caffeine and siloxanetriol alginate caffeine on fatty tissue by histological evaluation.


METHODS
Formulations were developed with caffeine, caffeine + sodium benzoate or SAC and were applied topically for 21 days on Wistar female mice. The study regarded the histological aspects by determination of diameter and number of fatty cells with a light microscope.


RESULTS
Emulsion with caffeine caused a reduction of 17% on the diameter of the fatty cells compared with the control. The emulsion with caffeine + sodium benzoate did not cause alterations on cell diameter. Emulsion with SAC provoked reduction on fatty cell diameters of 16%. No significant alterations were observed on the diameter of the fatty cells treated with gels, although it was noticed that gel with SAC promoted a reduction of 26% on the number of fatty cells.


CONCLUSIONS
Emulsion with SAC was considered more indicated to promote the lipolytic action on fatty tissue, acting as a complement to treat cellulite. When sodium benzoate was added to the preparations, it inhibited the caffeine efficiency. Gel was not an adequate vehicle to be incorporated with caffeine and SAC.
Velasco
Maria Valéria Robles
MV
Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Tano
Clara Tsugmi Nakamura
CT
Machado-Santelli
Gláucia Maria
GM
Consiglieri
Vladi Olga
VO
Kaneko
Telma Mary
TM
Baby
André Rolim
AR
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects*; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects*; D000279:Administration, Cutaneous; D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004655:Emulsions / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005782:Gels / Q000737:chemistry / Q000494:pharmacology; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects; D051379:Mice; D017646:Organosilicon Compounds / Q000494:pharmacology*; D020160:Sodium Benzoate / Q000494:pharmacology*
D000464:Alginates; D004655:Emulsions; D005782:Gels; D006603:Hexuronic Acids; D017646:Organosilicon Compounds; D002110:Caffeine; D020723:Glucuronic Acid; D020160:Sodium Benzoate