title: Gymnastatins and dankastatins, growth inhibitory metabolites of a gymnascella species from a Halichondria sponge.
abstract: Four new metabolites, gymnastatins Q ( 3) and R ( 4) and dankastatins A ( 5) and B ( 6), have been isolated from the mycelial MeOH extract of a fungal strain of Gymnascella dankaliensis separated from a Halichondria sponge. Their stereostructures have been established on the basis of spectroscopic analysis using 1D and 2D NMR techniques. All of the isolated metabolites ( 3- 6) exhibited growth inhibition against the P388 cancer cell line. Furthermore, gymnastatin Q ( 3) showed appreciable growth inhibition against BSY-1 (breast) and MKN7 (stomach) human cancer cell lines.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Osaka, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Amagata
authors.forename: Makoto
authors.initials: M
authors.lastname: Tanaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Minoura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007564:Japan; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D001952:Bridged-Ring Compounds; C528785:dankastatin A; C528786:dankastatin B; C528783:gymnastatin Q; C528784:gymnastatin R