title: Genital tract interleukin-8 but not interleukin-1beta or interleukin-6 concentration is associated with bacterial vaginosis and its clearance in HIV-infected and HIV-uninfected women.
abstract: Genital tract infections and cytokine perturbations are associated with increased HIV acquisition and transmission. We measured the relationship between bacterial vaginosis (BV) and concentrations of Interleukin-8 (IL-8), Interleukin-1beta (IL-1beta), and Interleukin-6 (IL-6) in cervicovaginal lavage (CVL) specimens collected longitudinally from 16 HIV-infected and 8 HIV-uninfected high-risk women. CVL samples were analyzed when women presented with BV, and at their next visit, after successful treatment, when BV was cleared. A subset of participants had cytokine levels evaluated at three consecutive clinic visits: before developing BV, at the time of BV diagnosis, and after clearing BV. Significantly higher IL-8, but not IL-1beta or IL-6 levels were present when women had active BV compared to when BV was absent. Trends in cytokine levels were similar for HIV-infected and HIV-uninfected women. BV in these women was associated with significantly higher concentrations of genital tract IL-8 which decreased 2.4 fold when BV was cleared.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA. plosikoff@lifespan.org
authors.forename: Phyllis
authors.initials: P
authors.lastname: Losikoff
authors.forename: Raina
authors.initials: R
authors.lastname: Fichorova
authors.forename: Brad
authors.initials: B
authors.lastname: Snyder
authors.forename: Irma
authors.initials: I
authors.lastname: Rodriguez
authors.forename: Susan
authors.initials: S
authors.lastname: Cu-Uvin
authors.forename: Joseph
authors.initials: J
authors.lastname: Harwell
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000382:microbiology* / Q000821:virology; D006801:Humans; D007378:Interleukins / Q000276:immunology / Q000378:metabolism*; D008137:Longitudinal Studies; D012044:Regression Analysis; D014621:Vagina / Q000276:immunology / Q000382:microbiology; D016585:Vaginosis, Bacterial / Q000276:immunology* / Q000382:microbiology / Q000821:virology*
chemical_list: D007378:Interleukins