title: Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations.
abstract: Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR)=1.30, 95% confidence interval (CI); 1.13-1.49, p=0.00027, allele count model] and Koreans (OR=1.19, 95% CI; 1.02-1.38, p=0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.
authors.affiliation: Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hinohara
authors.affiliation: Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.|Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima
authors.affiliation: Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Department of Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hohda
authors.affiliation: Department of Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Taishi
authors.initials: T
authors.lastname: Sasaoka
authors.affiliation: Division of Internal Medicine, National Hospital Organization Nagasaki Medical Center, Ohmura, Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Nakahara
authors.affiliation: Department of Cardiology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Chida
authors.affiliation: Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan.
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.affiliation: Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
authors.forename: Takuro
authors.initials: T
authors.lastname: Arimura
authors.affiliation: Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Sato
authors.affiliation: Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
authors.forename: Bok-Soo
authors.initials: BS
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Ban
authors.affiliation: Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.|Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Yasunami
authors.affiliation: Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
authors.forename: Jeong-Euy
authors.initials: JE
authors.lastname: Park
authors.affiliation: Department of Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Izumi
authors.affiliation: Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan. akitis@mri.tmd.ac.jp.|Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. akitis@mri.tmd.ac.jp.
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
mesh_terms: D044466:Asian People / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007564:Japan; D007723:Korea; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018709:Statistics, Nonparametric
chemical_list: D017931:DNA Primers