Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus.
To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 were DNAemia-negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.
Revello
Maria Grazia
MG
Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. mg.revello@smatteo.pv.it
Furione
Milena
M
Zavattoni
Maurizio
M
Tassis
Beatrice
B
Nicolini
Umberto
U
Fabbri
Elisa
E
Gerna
Giuseppe
G
D000649:Amniocentesis / Q000009:adverse effects*; D015415:Biomarkers; D015331:Cohort Studies; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000635:transmission*; D004279:DNA, Viral / Q000097:blood*; D005188:False Negative Reactions; D005260:Female; D005865:Gestational Age; D006801:Humans; D007049:Iatrogenic Disease; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies
D015415:Biomarkers; D004279:DNA, Viral