[Methods to evaluate aspirin and clopidogrel resistance].
Based on the concept that the so-called resistance to anti-platelet drugs is meant to describe a phenomenon where the drug does not hit its direct pharmacodynamic target, assays, used to evaluated the effects of anti-platelet drugs, should as closely as possible measure the direct pharmacodynamic effect of a particular drug. Thus, for the detection of aspirin effects, thromboxane concentrations or arachidonic acid-induced responses (light aggregometry, whole-blood aggregometry) should be measured. For the detection of clopidogrel actions, VASP phosphorylation (flow cytometry) or ADP-induced responses (light aggregometry, whole blood aggregometry) should be analysed.
Weber
A-A
AA
Institut für Pharmakologie, Universität Duisburg-Essen, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany. artur.weber@uk-essen.de
Adamzik
M
M
Bachmann
H S
HS
Görlinger
K
K
Grandoch
M
M
Leineweber
K
K
Müller-Beissenhirtz
H
H
Wenzel
F
F
Naber
C
C
D001241:Aspirin / Q000627:therapeutic use*; D000077144:Clopidogrel; D004351:Drug Resistance; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin