Connections of cat auditory cortex: III. Corticocortical system.
The mammalian auditory cortex (AC) is essential for computing the source and decoding the information contained in sound. Knowledge of AC corticocortical connections is modest other than in the primary auditory regions, nor is there an anatomical framework in the cat for understanding the patterns of connections among the many auditory areas. To address this issue we investigated cat AC connectivity in 13 auditory regions. Retrograde tracers were injected in the same area or in different areas to reveal the areal and laminar sources of convergent input to each region. Architectonic borders were established in Nissl and SMI-32 immunostained material. We assessed the topography, convergence, and divergence of the labeling. Intrinsic input constituted >50% of the projection cells in each area, and extrinsic inputs were strongest from functionally related areas. Each area received significant convergent ipsilateral input from several fields (5 to 8; mean 6). These varied in their laminar origin and projection density. Major extrinsic projections were preferentially from areas of the same functional type (tonotopic to tonotopic, nontonotopic to nontonotopic, limbic-related to limbic-related, multisensory-to-multisensory), while smaller projections link areas belonging to different groups. Branched projections between areas were <2% with deposits of two tracers in an area or in different areas. All extrinsic projections to each area were highly and equally topographic and clustered. Intrinsic input arose from all layers except layer I, and extrinsic input had unique, area-specific infragranular and supragranular origins. The many areal and laminar sources of input may contribute to the complexity of physiological responses in AC and suggest that many projections of modest size converge within each area rather than a simpler area-to-area serial or hierarchical pattern of corticocortical connectivity.
Lee
Charles C
CC
Division of Neurobiology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3200, USA. clee@bsd.uchicago.edu
Winer
Jeffery A
JA
D000818:Animals; D001303:Auditory Cortex / Q000033:anatomy & histology* / Q000502:physiology; D001306:Auditory Pathways / Q000033:anatomy & histology / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology; D001369:Axons / Q000502:physiology / Q000648:ultrastructure*; D001931:Brain Mapping; D002415:Cats; D002772:Cholera Toxin; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D019044:Image Cytometry; D017729:Presynaptic Terminals / Q000502:physiology / Q000648:ultrastructure; D013194:Staining and Labeling; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; C062844:wheat germ agglutinin-apohorseradish peroxidase conjugate gold complex; D002772:Cholera Toxin