title: Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy.
abstract: We report the case of a 12-year-old boy who developed staphylococcal toxic shock syndrome associated with S. aureus pharyngeal colonization or infection. The diagnosis was rapidly confirmed by detecting the Vbeta signature of the toxic shock syndrome toxin-1 in peripheral blood, based on transient T cell depletion rapidly followed by massive expansion of Vbeta 2-positive T cells.
authors.affiliation: INSERM U851, Lyon F-69008, France. tristan.ferry@univ-lyon1.fr
authors.forename: Tristan
authors.initials: T
authors.lastname: Ferry
authors.forename: Damien
authors.initials: D
authors.lastname: Thomas
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Bouchut
authors.forename: Gerard
authors.initials: G
authors.lastname: Lina
authors.forename: Maryline
authors.initials: M
authors.lastname: Vasselon-Raina
authors.forename: Olivier
authors.initials: O
authors.lastname: Dauwalder
authors.forename: Yves
authors.initials: Y
authors.lastname: Gillet
authors.forename: François
authors.initials: F
authors.lastname: Vandenesch
authors.forename: Daniel
authors.initials: D
authors.lastname: Floret
authors.forename: Jerome
authors.initials: J
authors.lastname: Etienne
mesh_terms: D001427:Bacterial Toxins / Q000276:immunology*; D002648:Child; D042241:Early Diagnosis; D004768:Enterotoxins / Q000276:immunology*; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D012772:Shock, Septic / Q000175:diagnosis* / Q000276:immunology; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000276:immunology; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal