title: Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
abstract: A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
authors.affiliation: Evotec (UK) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United Kingdom. monika.ermann@evotec.com
authors.forename: Monika
authors.initials: M
authors.lastname: Ermann
authors.forename: Doris
authors.initials: D
authors.lastname: Riether
authors.forename: Edward R
authors.initials: ER
authors.lastname: Walker
authors.forename: Innocent F
authors.initials: IF
authors.lastname: Mushi
authors.forename: James E
authors.initials: JE
authors.lastname: Jenkins
authors.forename: Beatriz
authors.initials: B
authors.lastname: Noya-Marino
authors.forename: Mark L
authors.initials: ML
authors.lastname: Brewer
authors.forename: Malcolm G
authors.initials: MG
authors.lastname: Taylor
authors.forename: Patricia
authors.initials: P
authors.lastname: Amouzegh
authors.forename: Stephen P
authors.initials: SP
authors.lastname: East
authors.forename: Brian W
authors.initials: BW
authors.lastname: Dymock
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Gemkow
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Kahrs
authors.forename: Andreas
authors.initials: A
authors.lastname: Ebneth
authors.forename: Sabine
authors.initials: S
authors.lastname: Löbbe
authors.forename: Kathy
authors.initials: K
authors.lastname: O'Shea
authors.forename: Daw-Tsun
authors.initials: DT
authors.lastname: Shih
authors.forename: David
authors.initials: D
authors.lastname: Thomson
mesh_terms: D015394:Molecular Structure; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2