title: Effects interferon-2alpha on seizures in corasol-induced kindling.
abstract: Intracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.
authors.affiliation: Odessa State Medical University, Ukraine.
authors.forename: V I
authors.initials: VI
authors.lastname: Kresyun
authors.forename: E V
authors.initials: EV
authors.lastname: Kobolev
authors.forename: I V
authors.initials: IV
authors.lastname: Smirnov
authors.forename: V V
authors.initials: VV
authors.lastname: Godovan
authors.forename: L S
authors.initials: LS
authors.lastname: Godlevskii
mesh_terms: D000818:Animals; D004569:Electroencephalography / Q000187:drug effects; D016898:Interferon-alpha / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D016898:Interferon-alpha; D010433:Pentylenetetrazole