Spontaneous short-term variations of circulating endothelin-1 in pulmonary hypertension.
Endothelin-1 (ET-1) is overexpressed in pulmonary arteries of pulmonary hypertension (PH) patients and contributes to the sustained vasoconstriction, remodeling process, and thrombosis of vessels that underlie development and progression of this disease. Increased circulating ET-1 correlates with markers of PH severity, and ET-1 is regarded as a potential diagnostic and prognostic biomarker in PH. Because the within-individual variability measured in PH patients and in healthy subjects contributes to determine the biomarker predictive value and must be taken into account to establish cutoff values, we determined the short-term variability of circulating ET-1 in controls and in PH patients.
Charloux
Anne
A
Chaouat
Ari
A
Brandenberger
Gabrielle
G
Piquard
François
F
Weitzenblum
Emmanuel
E
Geny
Bernard
B
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery; D012016:Reference Values; D012680:Sensitivity and Specificity; D013997:Time Factors
D015415:Biomarkers; D019332:Endothelin-1