title: [Phosphoinositide-specific phospholipase C in mammalian cells: structure, properties, and function].
abstract: Phospholipase C (PLC) catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2) to yield diacylglycerol (DAG) and inositol-1,4,5-triphosphate (IP3). Phospholipase C activities have been described in several organisms, including bacteria, yeast, plants, and mammals. In mammalian cells, PLC (PLC-beta, PLC-gamma, PLC-delta, PLC-epsilon, PLC-zeta, and PLC-eta isoforms) has been implicated in intracellular signal transduction, vesicle transport, endocytosis, exocytosis, ion channel function, mitosis, cytoskeletal reorganization, and neuronal signal transduction. Mammalian phospholipase C is regulated by many factors, including calcium ions, receptor tyrosine kinases, and small G-proteins of the Ras and Rho families. In this review the structure and biological function of PLC are discussed.
authors.affiliation: Katedra i Zakład Biochemii, Akademia Medyczna w Warszawie. mszumilo@amwaw.edu.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Szumiło
authors.forename: Iwonna
authors.initials: I
authors.lastname: Rahden-Staroń
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D054801:Phosphoinositide Phospholipase C / Q000737:chemistry* / Q000378:metabolism*; D020033:Protein Isoforms; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007473:Ion Channels; D020033:Protein Isoforms; D054801:Phosphoinositide Phospholipase C