title: [Expression of HOX C13 in odontogenic tumors].
abstract: OBJECTIVE
  To study the expression of HOXC13 mRNA in odontogenic tumors.
  
  
  METHODS
  HOXC13 mRNA was detected in 47 cases of ameloblastoma (AB), 3 cases of calcifying cystic odontogenic tumor (CCOT), 3 cases of ameloblastic fibroma (AF), 10 cases of keratocystic odontogenic tumor (KCOT) and 2 cases of calcifying epithelial odontogenic tumor (CEOT) by in situ hybridization, and 7 cases of normal oral mucosa were selected as control. SPSS10.0 software package was used for chi(2) test.
  
  
  RESULTS
  HOXC13 mRNA was positively expressed in all odontogenic epithelium except AF. The positive ratios were 97.9% in AB, 100% in CCOT, 100% in CEOT, 70.0% in KCOT epithelium and 42.9% in the normal oral mucosa. There was significant difference among AB, KCOT and normal mucosa (chi(2)=21.665, P<0.001).
  
  
  CONCLUSIONS
  The genesis and development of odontogenic tumors are related to the high expression of HOXC13. The expression of HOXC13 mRNA in the odontogenic lesions has heterogeneity.
authors.affiliation: Department of Oral Pathology, College of Stomatology, China Medical University, Shenyang 110002, China.
authors.forename: Yan-song
authors.initials: YS
authors.lastname: Hong
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000564:Ameloblastoma; D018398:Homeodomain Proteins / Q000096:biosynthesis*; D006801:Humans; D009061:Mouth Mucosa; D018333:Odontogenic Cyst, Calcifying / Q000378:metabolism*; D009808:Odontogenic Tumors / Q000378:metabolism*; D012333:RNA, Messenger; D012878:Skin Neoplasms / Q000378:metabolism*
chemical_list: D018398:Homeodomain Proteins; D012333:RNA, Messenger