title: Multiple newly identified loci associated with prostate cancer susceptibility.
abstract: Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at </=60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 x 10(-8) to P = 8.7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.
authors.affiliation: The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK. rosalind.eeles@icr.ac.uk
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Kote-Jarai
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authors.lastname: Giles
authors.forename: Ali Amin Al
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authors.lastname: Olama
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authors.lastname: Jugurnauth
authors.forename: Shani
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authors.lastname: Mulholland
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authors.forename: David P
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authors.forename: Charmaine
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authors.lastname: Smith
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authors.initials: AT
authors.lastname: Ardern-Jones
authors.forename: Amanda L
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authors.lastname: Hall
authors.forename: Lynne T
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authors.lastname: O'Brien
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authors.lastname: Gehr-Swain
authors.forename: Rosemary A
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authors.lastname: Wilkinson
authors.forename: Angie
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authors.lastname: Cox
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authors.lastname: Lewis
authors.forename: Paul M
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authors.lastname: Brown
authors.forename: Sameer G
authors.initials: SG
authors.lastname: Jhavar
authors.forename: Malgorzata
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authors.lastname: Tymrakiewicz
authors.forename: Artitaya
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authors.lastname: Lophatananon
authors.forename: Sarah L
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authors.lastname: Horwich
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authors.forename: Vincent S
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authors.lastname: Khoo
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authors.forename: Christopher J
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authors.lastname: Thompson
authors.forename: Tim
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authors.lastname: Christmas
authors.forename: Chris
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authors.lastname: Ogden
authors.forename: Cyril
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authors.lastname: Fisher
authors.forename: Charles
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authors.lastname: Jamieson
authors.forename: Colin S
authors.initials: CS
authors.lastname: Cooper
authors.forename: Dallas R
authors.initials: DR
authors.lastname: English
authors.forename: John L
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authors.lastname: Hopper
authors.forename: David E
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authors.forename: Douglas F
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authors.lastname: Easton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001315:Australia; D016022:Case-Control Studies; D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D040641:Quantitative Trait Loci; D006113:United Kingdom