[Relationship between GATA-3 and IL-12 in patients with allergic rhinitis].
OBJECTIVE
To explore the relationship between GATA-3 and IL-12 in patients with allergic rhinitis.


METHODS
The expression of GATA-3 was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in 37 patients with allergic rhinitis and 12 control samples. IL-12 was detected by enzyme-linked immunosorbent assay.


RESULTS
The relative density ratio of GATA-3 to GAPDH in AR patients was 0.579 +/- 0.102, and in control group was 0.128 +/- 0.021. The concentrations of IL-12 were (53.7 +/- 12.3) ng/g and (121.9 +/- 20.4) ng/g in the two groups respectively. The expression of GATA-3 was negatively correlated to the expression of IL-12 in patients with allergic rhinitis.


CONCLUSIONS
The overexpression of GATA-3 in patients with allergic rhinitis was related to the decrease of IL-12, and to increasing the expression of IL-12 in topical tissue could suppress the expression of GATA-3 and may improve the therapeutic effectiveness of AR.
Yao
Jun
J
Department of Otolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. Christyhui@126.com
Zhou
Hui
H
Xu
Mei
M
Zhang
Yuefei
Y
D016022:Case-Control Studies; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*
D050990:GATA3 Transcription Factor; D018664:Interleukin-12