Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
Using nociceptin-receptor-deficient mice, we studied the participation of nociceptin in herpetic and postherpetic allodynia in mice. Although nociceptin-receptor deficiency did not affect the development of skin lesions and herpetic allodynia, it prevented postherpetic allodynia. Messenger ribonucleic acid (mRNA) of pronociceptin increased in the dorsal horn of lumbar enlargement on day 6, but not on day 40, after inoculation. No changes were observed in the mRNA of the nociceptin receptor. Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia. These results suggest that the spinal nociceptin system is involved in the transitional process from herpetic allodynia to postherpetic allodynia.
Sasaki
Atsushi
A
Department of aApplied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyamai, Japan.
Takasaki
Ichiro
I
Andoh
Tsugunobu
T
Shiraki
Kimiyasu
K
Takeshima
Hiroshi
H
Takahata
Hiroki
H
Kuraishi
Yasushi
Y
D000208:Acute Disease; D000588:Amines / Q000008:administration & dosage; D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage; D004195:Disease Models, Animal; D000077206:Gabapentin; D005786:Gene Expression Regulation / Q000187:drug effects; D006561:Herpes Simplex / Q000150:complications*; D018259:Herpesvirus 1, Human; D006930:Hyperalgesia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010147:Pain Measurement; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011957:Receptors, Opioid / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage; D000094942:Nociceptin Receptor
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D011498:Protein Precursors; D012333:RNA, Messenger; D011957:Receptors, Opioid; C119224:pronociceptin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D000094942:Nociceptin Receptor