title: Regulation of secondary metabolite production in filamentous ascomycetes.
abstract: Fungi are renowned for their ability to produce bioactive small molecules otherwise known as secondary metabolites. These molecules have attracted much attention due to both detrimental (e.g. toxins) and beneficial (e.g. pharmaceuticals) effects on human endeavors. Once the topic only of chemical and biochemical studies, secondary metabolism research has reached a sophisticated level in the realm of genetic regulation. This review covers the latest insights into the processes regulating secondary metabolite production in filamentous fungi.
authors.affiliation: Plant Pathology Department, University of Wisconsin-Madison, Russell Laboratories, 1630 Linden Drive, Madison, WI 53706, USA.
authors.forename: E Keats
authors.initials: EK
authors.lastname: Shwab
authors.forename: Nancy P
authors.initials: NP
authors.lastname: Keller
mesh_terms: D001203:Ascomycota / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D005656:Fungal Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005810:Multigene Family; D009183:Mycotoxins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D005656:Fungal Proteins; D009183:Mycotoxins