[Genetic risk factors for development of myocardial infarction in young men living in North-West region of Russia].
With the aim to detect genetic factors of risk of development of early myocardial infarction (MI) we studied 29 allele variants of 19 genes in 206 men who had survived MI in the age before 45 years and in 195 men of similar age without cardiovascular diseases. All subjects were inhabitants of North-West region of Russia. The following factors were associated with history of myocardial infarction: genotype RR191 of paraoxonase-1 (PON1) gene (RR 2.8 [95% CI: 1.24 - 6.30]), P1A2 allele of glycoprotein (GP) IIIa subunit of platelet fibrinogen receptor GPIIb/IIIa (RR 1.8 [95% CI: 1.11 - 2.93]), and Met145 allele of GPIbalpha platelet von Willebrand factor receptor gene. Genotype CC ( - 108) PON1 was associated with lowered risk of MI development (RR 0.6 [95% CI: 0.40 - 0.91]). During 7 years of follow-up 30 men from MI group died of recurrent acute coronary syndromes. In the group of those who died we noted increased prevalence of P1A2 GPIIIa allele compared with those who survived (p < 0.03). The results allow to suggest that contribute to development of MI in young men factors associated with elevation of functional state of platelets and levels of oxidized lipids in blood plasma.
Pchelina
S N
SN
Sirotkina
O V
OV
Sheĭdina
A M
AM
Taraskina
A E
AE
Rodygina
T I
TI
Demina
E P
EP
Zabotina
A M
AM
Mitupova
M I
MI
Bazhenova
E A
EA
Berkovich
O A
OA
Shliakhto
E V
EV
Shvartsman
A L
AL
Shvarts
E I
EI
D054058:Acute Coronary Syndrome / Q000401:mortality; D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics; D001792:Blood Platelets / Q000378:metabolism*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics; D039661:Integrin beta3 / Q000235:genetics; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics; D010980:Platelet Membrane Glycoproteins / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D012008:Recurrence; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
C061248:ITGB3 protein, human; D039421:Integrin alpha2; D039661:Integrin beta3; D008055:Lipids; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; C028254:von Willebrand factor receptor; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human