[Clozapine-induced agranulocytosis and Sweet's syndrome in a 74-year-old female patient. A case study].
A 74-year-old psychotic female patient who was treated with clozapine developed Sweet's syndrome followed by agranulocytosis from which she later died. A link between these two conditions seems unlikely. Sweet's syndrome is characterised by an acute onset of fever, leukocytosis and erythematous plaques with dense neutrophilic infiltrates. Frequent counting of the numbers of neutrophiles is advisable when skin disorders appear during treatment with clozapine.
Kleinen
J M P
JM
Ten tijde van het schrijven van dit artikel arts in Opleiding tot psychiater aan het Universitair Psychiatrisch Centrum KU Leuven, campus Kortenberg en is momenteel als psychiater verbonden aan het Psychotherapeutisch Centrum DeViersprong in Halsteren.
Bouckaert
F
F
Peuskens
J
J
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000401:mortality; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D016463:Sweet Syndrome / Q000139:chemically induced*
D003024:Clozapine