Effects of alpha1-acid glycoprotein on free radical oxidation processes in experimental liver failure.
The effects of alpha1-acid glycoprotein (2 intraperitoneal injections in a total dose of 300 mg/kg) on free radical oxidation during liver failure were studied in 53 outbred rats. On day 3 of liver failure, glycoprotein reduced plasma concentrations of free radical oxidation products, elevated the antioxidant potential of the plasma and liver and kidney homogenates, and restored functional reserve and capacity of leukocytes to generation of oxygen radicals.
Osikov
M V
MV
Department of Pathophysiology, Chelyabinsk State Medical Academy. mvo2003@list.ru
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000097:blood*; D017093:Liver Failure / Q000378:metabolism*; D049449:Luminescence; D008297:Male; D009961:Orosomucoid / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats
D005609:Free Radicals; D009961:Orosomucoid; D006861:Hydrogen Peroxide