title: Metastasized squamous cell carcinoma developed on lupus vulgaris.
abstract: Lupus vulgaris (LV) is the most frequent cutaneous tuberculosis, representing more than 55% of the tuberculoses with this location. Malignization can occur after a long latency (10-30 years), in 1-2% of the cases, and it is mainly in squamous cell carcinoma. The histological exam is highly important in the observation of neoplasic transformations. The authors present a 59-years-old female patient, from the rural environment, working as a farmer, with lupus vulgaris developing since her first childhood years. It started at the age of 2 years, at the right ear lobule, after the empiric perforation for earrings. The evolution was progressive, eccentric, interesting the pinna and the right cheek in the meanwhile. At the first examination, in 2002, a diffuse mass of red-yellowish infiltration was found at the level of the right ear and the right cheek. In the following two years, an ulcero-vegetating tumor developed at the level of the right ear lobule, accompanied by the presence of a right retromandibular adenopathy, of about 1 cm, which was proved by the histopathologic exam to be a squamous cell carcinoma developed from a lupus vulgaris. After scraping out the right retromandibular ganglion, detected by palpation, a histological exam showed ganglion metastasis.
authors.affiliation: Department of Dermatology, Emergency County Hospital of Craiova, University of Medicine and Pharmacy of Craiova, Craiova, Romania. vm.patrascu@gmail.com
authors.forename: V
authors.initials: V
authors.lastname: Pătraşcu
authors.forename: Claudia Valentina
authors.initials: CV
authors.lastname: Georgescu
authors.forename: Loredana Elena
authors.initials: LE
authors.lastname: Tănase
authors.forename: S S
authors.initials: SS
authors.lastname: Mogoantă
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D005153:Facial Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008177:Lupus Vulgaris / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D000995:Antitubercular Agents