title: Complexity analysis of arterial pressure during periods of abrupt hemodynamic changes.
abstract: In this communication, we estimated the Lempel-Ziv complexity (LZC) on over 40 h of arterial blood pressure (ABP) recordings corresponding to 18 mechanically ventilated animal subjects. In this study, all subjects underwent a period of abrupt hemodynamic changes after an induced injury involving severe blood loss leading to hemorrhagic shock, followed by fluid resuscitation using either lactated ringers or 0.9% normal saline. The LZC metric experienced a statistically significant increase (p < 0.01) immediately following the induced injury and a statistically significant reduction following the administration of fluid therapy (p < 0.01). These results indicate that LZC of ABP may be useful as a dynamic metric to assess fluid responsiveness.
authors.affiliation: Grupo de Ingeniería Biomédica (GIB) E T S Ingenieros de Telecomunicación University of Valladolid Camino del Cementerio s/no, 47011 Valladolid, Spain. robhor@tel.uva.es
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
authors.forename: Mateo
authors.initials: M
authors.lastname: Aboy
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez
authors.forename: Daneil S
authors.initials: DS
authors.lastname: Hagg
authors.forename: Charles R
authors.initials: CR
authors.lastname: Phillips
mesh_terms: D000465:Algorithms; D000818:Animals; D001794:Blood Pressure; D003198:Computer Simulation; D006470:Hemorrhage / Q000503:physiopathology*; D008955:Models, Cardiovascular; D013552:Swine