The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades.
The Na/K-ATPase was discovered by Skou in 1957. Since then, the efforts of numerous investigators have led to the following conclusions: (a) This enzyme is indeed the molecular machine for the ATP-dependent and -coupled transport of Na(+) and K(+) across the plasma membrane of a living cell in which such a process (sodium pump) is detected. (b) The Na/K-ATPase is also an important signal transducer that not only interacts and regulates protein kinases, but also functions as a scaffold, capable of bringing the affector and effectors together to form functional signalosomes. This minireview discusses the interaction between the Na/K-ATPase and Src to illustrate how a P-type ATPase can act as a receptor, converting a ligand-binding signal to the activation of protein kinase cascades and the generation of second messengers.
Li
Zhichuan
Z
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Mail Stop 1008, 3000 Arlington Avenue, Toledo, OH 43614-2598, USA.
Xie
Zijian
Z
D000818:Animals; D002316:Cardiotonic Agents / Q000378:metabolism*; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000378:metabolism*; D011487:Protein Conformation; D015290:Second Messenger Systems / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*; D019061:src-Family Kinases / Q000378:metabolism*
D002316:Cardiotonic Agents; D046912:Multiprotein Complexes; D013256:Steroids; D019061:src-Family Kinases; D000254:Sodium-Potassium-Exchanging ATPase