Running rings around chromosomes to trim axons and target dendrites.
The cohesin protein complex holds sister chromatids together to ensure proper chromosome segregation at mitosis in dividing cells. New experiments by two laboratories (reviewed in this issue of Developmental Cell) using different techniques reveal that cohesin also plays critical roles in morphogenesis of nondividing neurons. Other recent studies argue that these roles involve regulation of gene transcription.
Dorsett
Dale
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Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO 63104, USA. dorsettd@slu.edu
D000818:Animals; D001369:Axons / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism*; D004251:DNA Transposable Elements; D003712:Dendrites / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism; D000097722:Cohesins; D000098550:Structural Maintenance of Chromosome Protein 1
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004251:DNA Transposable Elements; D029721:Drosophila Proteins; D010450:Endopeptidases; D009687:Nuclear Proteins; D011987:Receptors, Steroid; D000097722:Cohesins; D000098550:Structural Maintenance of Chromosome Protein 1; C055469:ecdysone receptor; C410884:vtd protein, Drosophila; C099488:TEV protease