title: The potential for dose dumping in normal tissues with IMRT for pelvic and H&N cancers.
abstract: The purpose of this study is to understand the potential for dose dumping in normal tissues (>85% of prescription dose) and to analyze effectiveness of techniques used in reducing dose dumping during IMRT. Two hundred sixty-five intensity modulated radiation therapy (IMRT) plans for 55 patients with prostate, head-and-neck (H&N), and cervix cancers with 6-MV photon beams and >5 fields were reviewed to analyze why dose dumping occurred, and the techniques used to reduce dose dumping. Various factors including gantry angles, depth of beams (100-SSD), duration of optimization, severity of dose-volume constraints (DVC) on normal structures, and spatial location of planning treatment volumes (PTV) were reviewed in relation to dose dumping. In addition, the effect of partial contouring of rectum in beam's path on dose dumping in rectum was studied. Dose dumping occurred at d(max) in 17 pelvic cases (85% to 129%). This was related to (1) depth of beams (100 SSD [source-to-skin distance]), (2) PTV located between normal structures with DVC, and (3) relative lack of rectum and bladder in beam's path. Dose dumping could be reduced to 85% by changing beam angles and/or DVC for normal structures in 5 cases and by creating "phantom structures" in 12 cases. Decreasing the iterations (duration of optimization) also reduced dose dumping and monitor units (MUs). Part of uncontoured rectum, if present in the field, received a higher dose than the contoured rectum with DVC, indicating that complete delineation of normal structures and DVC is necessary to prevent dose dumping. In H&N, when PTV extends inadvertently into air beyond the body even by a few millimeters, dose dumping occurred in beam's path (220% for 5-field and 170%, 7-field plans). Keeping PTV margins within body contour reduced this type of dose dumping. Beamlet optimization, duration of optimization, spatial location of PTV, and DVC on PTV and normal structures has the potential to cause dose dumping. However, these factors are an integral part of IMRT inverse planning. Therefore, understanding these aspects and use of appropriate technique/s would reduce or eliminate the dose dumping and minimize time to obtain optimum plan.
authors.affiliation: Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY, USA.
authors.forename: Nandanuri M S
authors.initials: NM
authors.lastname: Reddy
authors.forename: Andrzej K
authors.initials: AK
authors.lastname: Mazur
authors.forename: Seshadri
authors.initials: S
authors.lastname: Sampath
authors.forename: Adrian
authors.initials: A
authors.lastname: Osian
authors.forename: Brij M
authors.initials: BM
authors.lastname: Sood
authors.forename: Akkamma
authors.initials: A
authors.lastname: Ravi
authors.forename: Dattatreyudu
authors.initials: D
authors.lastname: Nori
mesh_terms: D001822:Body Burden; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods*; D012062:Relative Biological Effectiveness; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors