Brain tumor imaging in clinical trials.
There are substantial challenges in the radiologic evaluation of tumor size during clinical trials, and it is important for neuroradiologists to have a firm understanding of these issues. This review will examine measurement approaches, response criteria, selection of lesions for measurement, technical imaging considerations, interval between tumor measurements and response confirmation, and validity of imaging as a measure of efficacy.
Henson
J W
JW
Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. henson@helix.mgh.harvard.edu
Ulmer
S
S
Harris
G J
GJ
D000465:Algorithms; D001932:Brain Neoplasms / Q000175:diagnosis*; D002986:Clinical Trials as Topic; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*