title: Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males.
abstract: Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia. Altered superoxide dismutase (SOD) and increased lipid peroxidation, measured by the thiobarbituric acid reactive substances (TBARS), are increased in schizophrenia. The aim of this study was to determine the effects of clinical course and subtype on oxidative stress parameters. In this study, 68 male patients, classified according to DSM-IV schizophrenia subtypes and clinical course (partial remission, marked symptoms, and deteriorated), were studied, and TBARS and SOD measured. Mean serum SOD and mean serum TBARS concentrations were similarly not significantly different among different subtypes (paranoid, disorganized and undifferentiated). However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males.
authors.affiliation: Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil. csgama@yahoo.com
authors.forename: Clarissa Severino
authors.initials: CS
authors.lastname: Gama
authors.forename: Mirian
authors.initials: M
authors.lastname: Salvador
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
authors.forename: Maria Ines
authors.initials: MI
authors.lastname: Lobato
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.forename: Flavio
authors.initials: F
authors.lastname: Kapczinski
authors.forename: Paulo Silva
authors.initials: PS
authors.lastname: Belmonte-de-Abreu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D011237:Predictive Value of Tests; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D012720:Severity of Illness Index; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood; D000072105:Superoxide Dismutase-1; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers; C000606290:SOD1 protein, human; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1