Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
Gudmundsson
Julius
J
deCODE genetics, 101 Reykjavik, Iceland. julius@decode.is
Sulem
Patrick
P
Rafnar
Thorunn
T
Bergthorsson
Jon T
JT
Manolescu
Andrei
A
Gudbjartsson
Daniel
D
Agnarsson
Bjarni A
BA
Sigurdsson
Asgeir
A
Benediktsdottir
Kristrun R
KR
Blondal
Thorarinn
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Jakobsdottir
Margret
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Stacey
Simon N
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Kostic
Jelena
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Kristinsson
Kari T
KT
Birgisdottir
Birgitta
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Ghosh
Shyamali
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Magnusdottir
Droplaug N
DN
Thorlacius
Steinunn
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Thorleifsson
Gudmar
G
Zheng
S Lilly
SL
Sun
Jielin
J
Chang
Bao-Li
BL
Elmore
J Bradford
JB
Breyer
Joan P
JP
McReynolds
Kate M
KM
Bradley
Kevin M
KM
Yaspan
Brian L
BL
Wiklund
Fredrik
F
Stattin
Par
P
Lindström
Sara
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Adami
Hans-Olov
HO
McDonnell
Shannon K
SK
Schaid
Daniel J
DJ
Cunningham
Julie M
JM
Wang
Liang
L
Cerhan
James R
JR
St Sauver
Jennifer L
JL
Isaacs
Sara D
SD
Wiley
Kathleen E
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Partin
Alan W
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Walsh
Patrick C
PC
Polo
Sonia
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Ruiz-Echarri
Manuel
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Navarrete
Sebastian
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Fuertes
Fernando
F
Saez
Berta
B
Godino
Javier
J
Weijerman
Philip C
PC
Swinkels
Dorine W
DW
Aben
Katja K
KK
Witjes
J Alfred
JA
Suarez
Brian K
BK
Helfand
Brian T
BT
Frigge
Michael L
ML
Kristjansson
Kristleifur
K
Ober
Carole
C
Jonsson
Eirikur
E
Einarsson
Gudmundur V
GV
Xu
Jianfeng
J
Gronberg
Henrik
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Smith
Jeffrey R
JR
Thibodeau
Stephen N
SN
Isaacs
William B
WB
Catalona
William J
WJ
Mayordomo
Jose I
JI
Kiemeney
Lambertus A
LA
Barkardottir
Rosa B
RB
Gulcher
Jeffrey R
JR
Thorsteinsdottir
Unnur
U
Kong
Augustine
A
Stefansson
Kari
K
D016022:Case-Control Studies; D002889:Chromosomes, Human, Pair 2; D041321:Chromosomes, Human, X; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007055:Iceland; D015810:Linkage Disequilibrium; D008297:Male; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D013030:Spain; D013548:Sweden; D014481:United States