title: Firefly luminescence: a historical perspective and recent developments.
abstract: Significant advances have occurred regarding our knowledge of firefly luciferase mechanisms. Although most of this progress was an outcome of molecular biology and structural studies, important achievements have also occurred on its fundamental chemistry. Those developments are here summarized and presented in a historical perspective.
authors.affiliation: Centro de Investigação em Química (UP), Departamento de Química, Faculdade de Ciências da Universidade do Porto, R. Campo Alegre 687, 4169-007, Porto, Portugal. hugo_fraga@hms.harvard.edu
authors.forename: Hugo
authors.initials: H
authors.lastname: Fraga
mesh_terms: D000818:Animals; D048888:Fireflies / Q000502:physiology*; D007700:Kinetics; D008156:Luciferases / Q000737:chemistry / Q000378:metabolism; D049449:Luminescence; D009705:Nucleosides / Q000096:biosynthesis; D011487:Protein Conformation
chemical_list: D009705:Nucleosides; D008156:Luciferases