title: Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa.
abstract: We report a case of pyogranulomatous pneumonia due to infection with Mycobacterium goodii in an adult female spotted hyena (Crocuta crocuta). The lungs of the animal showed consolidated, granulomatous lesions, and they were extensively and severely infiltrated. Polymerase chain reaction sequencing of isolated crude lung tissue DNA, and boiled lung culture samples, all confirmed that the causative organism was M. goodii, a recently described fast-growing organism closely related to the nonpathogenic mycobacterial species M. smegmatis. The current study illustrates that this organism can be pathogenic and cause extensive pulmonary disease.
authors.affiliation: DST/NRF Centre of Excellence for Biomedical TB Research/Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences-Stellenbosch University, Tygerberg, South Africa. pvh@sun.ac.za
authors.forename: Paul D
authors.initials: PD
authors.lastname: van Helden
authors.forename: Nico C
authors.initials: NC
authors.lastname: Gey van Pittius
authors.forename: Robin M
authors.initials: RM
authors.lastname: Warren
authors.forename: Anita
authors.initials: A
authors.lastname: Michel
authors.forename: Tiny
authors.initials: T
authors.lastname: Hlokwe
authors.forename: Darshana
authors.initials: D
authors.lastname: Morar
authors.forename: Jacques
authors.initials: J
authors.lastname: Godfroid
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: du Plessis
authors.forename: Roy
authors.initials: R
authors.lastname: Bengis
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D045968:Hyaenidae / Q000382:microbiology*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009161:Mycobacterium / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013019:South Africa / Q000453:epidemiology
chemical_list: D004269:DNA, Bacterial