title: Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany.
abstract: OBJECTIVE
  To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI).
  
  
  METHODS
  Prospective controlled blinded study.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years.
  
  
  METHODS
  Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children.
  
  
  RESULTS
  There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence.
  
  
  CONCLUSIONS
  The ICSI children born at term develop normally, similar to SC children.
authors.affiliation: Zentrum für Hormon- und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Endokrinologikum Hamburg, Hamburg, Germany. a.k.ludwig@web.de
authors.forename: Annika
authors.initials: A
authors.lastname: Ludwig
authors.forename: Alexander
authors.initials: A
authors.lastname: Katalinic
authors.forename: Ute
authors.initials: U
authors.lastname: Thyen
authors.forename: Alastair G
authors.initials: AG
authors.lastname: Sutcliffe
authors.forename: Klaus
authors.initials: K
authors.lastname: Diedrich
authors.forename: Michael
authors.initials: M
authors.lastname: Ludwig
mesh_terms: D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D004644:Emotions; D005260:Female; D005858:Germany; D006801:Humans; D007360:Intelligence; D008137:Longitudinal Studies; D008297:Male; D008603:Mental Health; D009048:Motor Skills / Q000502:physiology*; D018579:Patient Selection; D011247:Pregnancy; D011446:Prospective Studies; D016037:Single-Blind Method; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000706:statistics & numerical data*