The effect of maternal betel quid exposure during pregnancy on adverse birth outcomes among aborigines in Taiwan.
In considering documented developmental toxicity and teratogenicity found in earlier research, maternal betel quid chewing may very well be linked to a higher risk of adverse birth outcomes. The aim of this study was to investigate the significance of betel quid chewing, together with the use of cigarettes or alcohol, either independently or combined, on birth-related outcomes. A total of 1264 aboriginal women who had just given birth in 10 hospitals in Southern and Eastern Taiwan were recruited. Information on their maternal and newborn characteristics was obtained from medical charts and by performing personal interviews using a validated questionnaire. Maternal areca nut chewing during pregnancy was found to be significantly associated with both birth weight loss (-89.54 g) and birth length reduction (-0.43 cm). A significantly lower male newborn rate (aOR=0.62) was observed among aboriginal women with a habit of betel quid chewing during pregnancy. The use of this substance conveyed a 2.40- and 3.67-fold independent risk of low birth weight and full-term low birth weight, respectively. An enhanced risk (aOR=3.26-5.99) of low birth weight was observed among women concomitantly using betel quid, cigarette and alcohol during gestation. Our findings suggest that betel quid chewing during pregnancy has a substantial effect on a number of birth outcomes, including sex ratio at birth, lower birth weight and reduced birth length.
Yang
Mei-Sang
MS
College of Nursing, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan.
Lee
Chien-Hung
CH
Chang
Shun-Jen
SJ
Chung
Tieh-Chi
TC
Tsai
Eing-Mei
EM
Ko
Allen Min-Jen
AM
Ko
Ying-Chin
YC
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D001114:Areca / Q000633:toxicity*; D044466:Asian People / Q000706:statistics & numerical data*; D001724:Birth Weight / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D016017:Odds Ratio; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012307:Risk Factors; D012744:Sex Ratio; D012907:Smoking / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000453:epidemiology*; D013624:Taiwan