title: Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
abstract: Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p<0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p=0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Province, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Liu
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Li
authors.forename: Min-Hao
authors.initials: MH
authors.lastname: Peng
authors.forename: Tang-Wei
authors.initials: TW
authors.lastname: Liu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Qin
authors.forename: Ya
authors.initials: Y
authors.lastname: Guo
authors.forename: Kai-Yin
authors.initials: KY
authors.lastname: Xiao
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Ye
authors.forename: Xin-Shao
authors.initials: XS
authors.lastname: Mo
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Lu-Nan
authors.initials: LN
authors.lastname: Yan
authors.forename: Han-Ming
authors.initials: HM
authors.lastname: Shen
authors.forename: LianWen
authors.initials: L
authors.lastname: Wang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.forename: Kai-bo
authors.initials: KB
authors.lastname: Wang
authors.forename: Ren-xiang
authors.initials: RX
authors.lastname: Liang
authors.forename: Zong-liang
authors.initials: ZL
authors.lastname: Wei
authors.forename: Choon Nam
authors.initials: CN
authors.lastname: Ong
authors.forename: Regina M
authors.initials: RM
authors.lastname: Santella
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D000328:Adult; D016604:Aflatoxin B1 / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012306:Risk
chemical_list: D015415:Biomarkers; D016604:Aflatoxin B1