Multiple malignant and benign lesions in the liver in a child with adrenocortical carcinoma.
We report 4-year-old girl who was diagnosed with adrenocortical carcinoma when she was 2 years old. At the time of diagnosis there were no metastases, but 6 months later multiple liver metastases appeared. Following intensive chemotherapy the metastases resolved completely. Multifocal lesions were detected in the liver by US 16 months later. Their morphology on US and MRI differed from the previous metastases. Histopathological examination confirmed focal nodular hyperplasia. We discuss the origin and the uncommon appearance of multifocal nodular hyperplasia in hormone-active tumours such as adrenocortical carcinoma in children.
Sorge
Ina
I
Department of Paediatric Radiology, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany. Ina.Sorge@medizin.uni-leipzig.de
Bierbach
Uta
U
Finke
Rainer
R
Hirsch
Wolfgang
W
D000306:Adrenal Cortex Neoplasms / Q000473:pathology* / Q000601:surgery; D018268:Adrenocortical Carcinoma / Q000473:pathology* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000139:chemically induced / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods; D035583:Rare Diseases; D014463:Ultrasonography