title: Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction.
abstract: Monocyte-chemotactic-protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased (P<001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012). In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR). Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in IUGR.
authors.affiliation: Second Department of Obstetrics and Gynecology, Athens University Medical School, 11528 Athens, Greece.
authors.forename: Despina D
authors.initials: DD
authors.lastname: Briana
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
authors.forename: George
authors.initials: G
authors.lastname: Papadopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gourgiotis
authors.forename: Karl Philipp
authors.initials: KP
authors.lastname: Puchner
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hassiakos
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
mesh_terms: D000328:Adult; D001724:Birth Weight; D018932:Chemokine CCL2 / Q000097:blood*; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000175:diagnosis; D005786:Gene Expression Regulation; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications; D012737:Sex Factors
chemical_list: D018932:Chemokine CCL2; D016207:Cytokines