Effect of ATP and its analogs on contractility of rat myocardium during ontogeny.
The effects of P2-receptor agonists on myocardial contractility were examined in rats aging 14-100 days. ATP and its stable analog 2-methylthio-ATP potentiated the contraction force of isolated myocardial strips in a dose-dependent manner. The agonist concentrations producing the positive inotropic effect increased from days 14 to 100 of life. The efficiency of extracellular purines depends on animal age: in 14- and 56-day rats the positive inotropic effects of ATP and 2-methylthio-ATP were similar, while in 100-day rats ATP produced more pronounced effect than 2-methylthio-ATP.
Anikina
T A
TA
Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University, Kazan. tania57vg1@rambler.ru
Bilalova
G A
GA
Zverev
A A
AA
Sitdikov
F G
FG
D000255:Adenosine Triphosphate / Q000819:agonists / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D003864:Depression, Chemical; D006321:Heart / Q000254:growth & development*; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D013873:Thionucleotides / Q000494:pharmacology*
D013873:Thionucleotides; D000255:Adenosine Triphosphate; C008501:2-methylthio-ATP