title: Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
abstract: BACKGROUND
  Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality.
  
  
  OBJECTIVE
  To compare an established low-tidal-volume ventilation strategy with an experimental strategy based on the original "open-lung approach," combining low tidal volume, lung recruitment maneuvers, and high positive-end-expiratory pressure.
  
  
  METHODS
  Randomized controlled trial with concealed allocation and blinded data analysis conducted between August 2000 and March 2006 in 30 intensive care units in Canada, Australia, and Saudi Arabia.
  
  
  METHODS
  Nine hundred eighty-three consecutive patients with acute lung injury and a ratio of arterial oxygen tension to inspired oxygen fraction not exceeding 250.
  
  
  METHODS
  The control strategy included target tidal volumes of 6 mL/kg of predicted body weight, plateau airway pressures not exceeding 30 cm H2O, and conventional levels of positive end-expiratory pressure (n = 508). The experimental strategy included target tidal volumes of 6 mL/kg of predicted body weight, plateau pressures not exceeding 40 cm H2O, recruitment maneuvers, and higher positive end-expiratory pressures (n = 475).
  
  
  METHODS
  All-cause hospital mortality.
  
  
  RESULTS
  Eighty-five percent of the 983 study patients met criteria for acute respiratory distress syndrome at enrollment. Tidal volumes remained similar in the 2 groups, and mean positive end-expiratory pressures were 14.6 (SD, 3.4) cm H2O in the experimental group vs 9.8 (SD, 2.7) cm H2O among controls during the first 72 hours (P < .001). All-cause hospital mortality rates were 36.4% and 40.4%, respectively (relative risk [RR], 0.90; 95% confidence interval [CI], 0.77-1.05; P = .19). Barotrauma rates were 11.2% and 9.1% (RR, 1.21; 95% CI, 0.83-1.75; P = .33). The experimental group had lower rates of refractory hypoxemia (4.6% vs 10.2%; RR, 0.54; 95% CI, 0.34-0.86; P = .01), death with refractory hypoxemia (4.2% vs 8.9%; RR, 0.56; 95% CI, 0.34-0.93; P = .03), and previously defined eligible use of rescue therapies (5.1% vs 9.3%; RR, 0.61; 95% CI, 0.38-0.99; P = .045).
  
  
  CONCLUSIONS
  For patients with acute lung injury and acute respiratory distress syndrome, a multifaceted protocolized ventilation strategy designed to recruit and open the lung resulted in no significant difference in all-cause hospital mortality or barotrauma compared with an established low-tidal-volume protocolized ventilation strategy. This "open-lung" strategy did appear to improve secondary end points related to hypoxemia and use of rescue therapies.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT00182195.
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada. meadema@hhsc.ca
authors.forename: Maureen O
authors.initials: MO
authors.lastname: Meade
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Cook
authors.forename: Gordon H
authors.initials: GH
authors.lastname: Guyatt
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Slutsky
authors.forename: Yaseen M
authors.initials: YM
authors.lastname: Arabi
authors.forename: D James
authors.initials: DJ
authors.lastname: Cooper
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Davies
authors.forename: Lori E
authors.initials: LE
authors.lastname: Hand
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Lehana
authors.initials: L
authors.lastname: Thabane
authors.forename: Peggy
authors.initials: P
authors.lastname: Austin
authors.forename: Stephen
authors.initials: S
authors.lastname: Lapinsky
authors.forename: Alan
authors.initials: A
authors.lastname: Baxter
authors.forename: James
authors.initials: J
authors.lastname: Russell
authors.forename: Yoanna
authors.initials: Y
authors.lastname: Skrobik
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Ronco
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D016019:Survival Analysis; D013990:Tidal Volume