title: Glycated haemoglobin or mean blood glucose as indicators of metabolic control in Type 2 diabetes?
abstract: The aim of the study was to assess whether HbA(1c) levels reflected mean blood glucose (MBG) levels in Type 2 diabetes. Despite the good correlation between HbA(1c) and MBG, one-third of the patients had consistently higher HbA(1c) or lower HbA(1c) levels than that expected under the hypothesis that HbA(1c) is solely determined by MBG, suggesting the existence of different haemoglobin glycation phenotypes. The use of HbA(1c) alone for glycemic control monitoring in these patients could be insufficient to clearly trace their risk of complications.
authors.affiliation: Metabolism and Diabetes Unit, Ospedale Renzetti, Lanciano, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Pupillo
authors.forename: Giorgia
authors.initials: G
authors.lastname: De Berardis
authors.forename: Daniela
authors.initials: D
authors.lastname: Antenucci
authors.forename: Anita
authors.initials: A
authors.lastname: Minnucci
authors.forename: Antonio
authors.initials: A
authors.lastname: Nicolucci
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004784:Environmental Monitoring / Q000379:methods*; D005215:Fasting; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin