Coenzyme Q10 and high-sensitivity C-reactive protein in ischemic and idiopathic dilated cardiomyopathy.
BACKGROUND
Cardiomyopathy (CMP) is a common debilitating illness, associated with a high mortality and poor quality of life. There is extensive evidence from in vitro and animal experiments that CMP is a state of increased oxidative stress. Coenzyme Q10 (CoQ10) and high-sensitivity C-reactive protein (hs-CRP) are important markers to evaluate the oxidative stress and inflammatory status of patients with CMP.


METHODS
A total of 28 patients with chronic stable heart failure (21 men and 7 women, ages 18-76 years) were included in the study. Causes of heart failure were ischemic CMP in 17 patients and idiopathic dilated CMP in 11 patients. A total of 28 patients (12 men and 16 women; ages 30-71 years) with normal coronary angiography were enrolled as a control group. Levels of CoQ10, albumin, total thiol groups (T-SH), bilirubin, uric acid as plasma antioxidants, hs-CRP as an inflammation marker and lipid profile were studied in patients and controls.


RESULTS
Plasma CoQ10, T-SH and albumin levels were significantly decreased in patients compared to controls. Uric acid, bilirubin and hs-CRP levels were found to be significantly increased compared to controls.


CONCLUSIONS
In this study, evidence of decreased antioxidant status was determined in CMP patients together with vascular inflammation. CoQ10, other plasma antioxidants and hs-CRP measured routinely can reflect decreased antioxidant status and inflammatory process in patients with dilated CMP. These markers can be used to monitor the status of patients with CMP.
Seneş
Mehmet
M
Department of Clinical Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey. senesmehmet@yahoo.com
Erbay
Ali Riza
AR
Yilmaz
F Meriç
FM
Topkaya
B Ciğdem
BC
Zengi
Oğuzhan
O
Doğan
Mehmet
M
Yücel
Doğan
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000201:enzymology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D013379:Substrate Specificity; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D014451:Ubiquinone; D002097:C-Reactive Protein; C024989:coenzyme Q10