A putative role for apelin in the etiology of obesity.
Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.
Rayalam
Srujana
S
Department of Animal & Dairy Science, University of Georgia, 444 Animal Science Complex, Athens, GA 30602-2771, USA.
Della-Fera
Mary Anne
MA
Krieg
Paul A
PA
Cox
Christopher M
CM
Robins
Allan
A
Baile
Clifton A
CA
D000273:Adipose Tissue / Q000098:blood supply* / Q000378:metabolism*; D000818:Animals; D000073861:Apelin; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009765:Obesity / Q000209:etiology* / Q000378:metabolism*
C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins