Characteristics of Devic's disease (neuromyelitis optica) in Mexico.
OBJECTIVE
To report clinical and epidemiological data of Devic's disease in Mexico.


METHODS
Retrospective study of hospital case records.


METHODS
The medical records were those of the National Institute for Neurology and Neurosurgery (INNN), a tertiary care referral center in Mexico City.


METHODS
There were 424 medical histories available for review among 561 discharges with diagnoses of multiple sclerosis (MS), neuromyelitis optica (NMO), or equivalents. 390 met the diagnostic criteria of MS and 34 the NMO criteria.


METHODS
We recorded clinical signs, visual acuities, and the Expanded Disability Status Scale (EDSS) at the initial diagnostic admission and during follow-up. All patients had examination of cerebrospinal fluid (CSF) at diagnosis; head and spine magnetic resonance imaging (MRI) were performed at diagnosis and at follow-up.


RESULTS
All 34 patients were Mexican Mestizos, who comprise 79 % of the residents of Mexico City. There were 23 monophasic and 11 relapsing cases. Intervals between initial and defining events for the 8 ON and 12 myelitis onsets were 17 and 24 months (means) and 15 and 17 months (medians), respectively. Mean follow- up from onset was 70.2 months and 42.9 months from diagnostic examination. No patient showed improvement in EDSS scores. Visual loss was severe.


CONCLUSIONS
A provisional prevalence rate of about 1 per 100,000 population for NMO in Mexican Mestizos might be offered. The disease seems more severe in our population than in other recent series.
Rivera
John Flores
JF
Dept. of Neurology, National Institute of Neurology and Neurosurgery, Insurgentes sur 3877, Mexico City, CP 14362, Mexico.
Kurtzke
John F
JF
Booth
Vanessa J Alatriste
VJ
Corona V
Teresa
T
D000328:Adult; D017668:Age of Onset; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009471:Neuromyelitis Optica / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D009900:Optic Nerve / Q000473:pathology* / Q000503:physiopathology; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000473:pathology* / Q000503:physiopathology; D015354:Vision, Low / Q000209:etiology / Q000503:physiopathology