Regulation of membrane trafficking in polarized epithelial cells.
Polarized epithelial cells continuously sort transmembrane proteins to either apical or basolateral plasma membrane domains. Research in recent years has made tremendous progress in understanding the molecular mechanisms of the major pathways to either basolateral or apical domain. This understanding will help us elucidating how these pathways are interconnected in ensuring maintenance of cell polarity and integrity of epithelial monolayers.
Fölsch
Heike
H
Department of Biochemistry, Molecular Biology & Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60202, USA. h-folsch@northwestern.edu
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans