Aspergillus "fungus ball" of the bladder after hematopoietic transplantation in a pediatric patient: successful treatment with intravesical voriconazole and surgery.
Aspergillosis is an important cause of mortality in allogeneic HSCT. A "fungus ball" formation of Aspergillus in the bladder has seldom been reported. We report a child that underwent HSCT and developed possible disseminated aspergillosis with an intravesical "fungus ball," diagnosed by genitourinary MRI and PCR of the mass that was removed from the bladder. It is important to consider this complication in a patient with HC after HSCT. The treatment included a combination of systemic antifungal therapy along with intravesical voriconazole and surgical removal.
González-Vicent
Marta
M
Pediatric Hematology-Oncology Section, Hospital Niño Jesús, Madrid, Spain. mgonzalezv.hnjs@salud.madrid.org
Lassaletta
Alvaro
A
López-Pino
Miguel Angel
MA
Romero-Tejada
Juan Carlos
JC
de la Fuente-Trabado
Manuel
M
Díaz
Miguel Angel
MA
D000283:Administration, Intravesical; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000628:therapy; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D003556:Cystitis / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D001745:Urinary Bladder Diseases / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole