Assignment of the absolute configuration of goniodomin A by NMR spectroscopy and synthesis of model compounds.
The complete absolute configuration of goniodomin A, an actin-targeting polyether macrolide isolated from the marine dinoflagellate Alexandrium hiranoi, was established from analysis of ROESY experiments and coupling constants, synthesis of suitable model compounds for NMR spectroscopic comparisons, degradation experiments, and correlation with synthetic reference compounds.
Takeda
Yoshiyuki
Y
Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-amamiya, Aoba-ku, Sendai 981-8555, Japan.
Shi
Jinglu
J
Oikawa
Masato
M
Sasaki
Makoto
M
D000199:Actins / Q000187:drug effects; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry*; D004141:Dinoflagellida / Q000737:chemistry; D004987:Ethers / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure
D000199:Actins; D000935:Antifungal Agents; D004987:Ethers; D018942:Macrolides; C059668:goniodomin A