[Mechanisms of neuronal death in Huntington's disease. Second part: therapeutic challenges].
Huntington's disease is caused by an abnormal CAG expansion within the gene encoding Huntingtin which induces a major cortico-striatal degeneration as well as motor and cognitive impairments. Since the discovery of the present mutation, a number of experimental data have been collected to uncover the physiopathological consequences of mutated Huntingtin expression. Here, we review the therapeutic challenges of Huntington's disease.
Bantubungi
K
K
INSERM U837, Centre de Recherche Jean-Pierre Aubert. Bantubungi@lille.inserm.fr
Blum
D
D
D016923:Cell Death; D015316:Genetic Therapy; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D009410:Nerve Degeneration / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000473:pathology; D014158:Transcription, Genetic