Assessment of the phototoxic potential of cosmetic products.
The cosmetics are nontoxic or less toxic in perse but photoactivation may then sensitize and could produce additional phototoxicity. Phototoxicity assessment of ten different lipsticks and eight facial creams was conducted. Results revealed that six lipsticks and five facial creams generated reactive oxygen species (ROS), produced haemolysis and caused lipid peroxidation in human erythrocytes (in vitro) under sunlight exposure. Seven creams and one lipstick were alkaline while one cream and two lipsticks were acidic. The test lipsticks and creams showed absorption in UV/visible range. The study demonstrated synergistic action of cosmetic products and sunlight. Therefore, sunlight exposure should be avoided after the use of photosensitive cosmetics.
Hans
Rajendra K
RK
Photobiology Division, Industrial Toxicology Research Centre, MG Marg, Lucknow, UP, India. rkhans2004@rediffmail.com
Agrawal
Neeraj
N
Verma
Kiran
K
Misra
Rajendra B
RB
Ray
Ratan S
RS
Farooq
Mohammad
M
D003358:Cosmetics / Q000633:toxicity*; D017484:Dermatitis, Phototoxic / Q000473:pathology*; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000032:analysis; D013472:Sunlight; D013481:Superoxides / Q000032:analysis; D014466:Ultraviolet Rays
D003358:Cosmetics; D007202:Indicators and Reagents; D017382:Reactive Oxygen Species; D013481:Superoxides