title: Metabolism of halophilic archaea.
abstract: In spite of their common hypersaline environment, halophilic archaea are surprisingly different in their nutritional demands and metabolic pathways. The metabolic diversity of halophilic archaea was investigated at the genomic level through systematic metabolic reconstruction and comparative analysis of four completely sequenced species: Halobacterium salinarum, Haloarcula marismortui, Haloquadratum walsbyi, and the haloalkaliphile Natronomonas pharaonis. The comparative study reveals different sets of enzyme genes amongst halophilic archaea, e.g. in glycerol degradation, pentose metabolism, and folate synthesis. The carefully assessed metabolic data represent a reliable resource for future system biology approaches as it also links to current experimental data on (halo)archaea from the literature.
authors.affiliation: Department of Membrane Biochemistry, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Falb
authors.forename: Kerstin
authors.initials: K
authors.lastname: Müller
authors.forename: Lisa
authors.initials: L
authors.lastname: Königsmaier
authors.forename: Tanja
authors.initials: T
authors.lastname: Oberwinkler
authors.forename: Patrick
authors.initials: P
authors.lastname: Horn
authors.forename: Susanne
authors.initials: S
authors.lastname: von Gronau
authors.forename: Orland
authors.initials: O
authors.lastname: Gonzalez
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Pfeiffer
authors.forename: Erich
authors.initials: E
authors.lastname: Bornberg-Bauer
authors.forename: Dieter
authors.initials: D
authors.lastname: Oesterhelt
mesh_terms: D019605:Euryarchaeota / Q000502:physiology*; D005492:Folic Acid / Q000096:biosynthesis*; D020745:Genome, Archaeal / Q000502:physiology*; D005990:Glycerol / Q000378:metabolism*; D010429:Pentoses / Q000378:metabolism*
chemical_list: D010429:Pentoses; D005492:Folic Acid; D005990:Glycerol