title: Factors that may mediate the relationship between physical activity and the risk for developing knee osteoarthritis.
abstract: Studies investigating the effect of physical activity on risk for developing osteoarthritis at weight-bearing joints have reported conflicting results. We examine evidence to suggest that this may be due to the existence of subgroups of individuals who differ in their response to physical activity, as well as methodological issues associated with the assessment of knee joint structure and physical activity. Recommendations for future studies of physical activity and the development of knee osteoarthritis are discussed.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Commercial Road, Melbourne 3004, Australia. Donna.Urquhart@med.monash.edu.au
authors.forename: Donna M
authors.initials: DM
authors.lastname: Urquhart
authors.forename: Cathy
authors.initials: C
authors.lastname: Soufan
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Teichtahl
authors.forename: Anita E
authors.initials: AE
authors.lastname: Wluka
authors.forename: Fahad
authors.initials: F
authors.lastname: Hanna
authors.forename: Flavia M
authors.initials: FM
authors.lastname: Cicuttini
mesh_terms: D000367:Age Factors; D001823:Body Composition; D015992:Body Mass Index; D006801:Humans; D007718:Knee Injuries / Q000150:complications; D007719:Knee Joint / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging; D009043:Motor Activity; D053580:Muscle Strength; D020370:Osteoarthritis, Knee / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors