[Correction of cardiotoxic effect of chronic alcoholic intoxication by GABA-ergic compounds].
Toxic effect of 50% ethanol solution (8 g/kg) on the heart appeared as diminishment of contractile properties of the myocardium. Structural GABA-analogues - citrocard (50 mg/kg), phenibut (50 mg/kg) and pyracetam (200 mg/kg) prevented injurious action of alcohol. This was evidenced by higher indices of contraction and relaxation velocity, and left ventricular pressure in intervention groups of animals compared with controls during functional tests with volume and maximal isometric load.
Perfilova
V N
VN
Tiurenkov
I N
IN
Lebedeva
S A
SA
D000437:Alcoholism / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D018682:GABA Agents / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D018697:Nootropic Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D016896:Treatment Outcome; D017725:Ventricular Pressure / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D018682:GABA Agents; D018697:Nootropic Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam