Control of alternative pre-mRNA splicing by Ca(++) signals.
Alternative pre-mRNA splicing is a common way of gene expression regulation in metazoans. The selective use of specific exons can be modulated in response to various manipulations that alter Ca(++) signals, particularly in neurons. A number of splicing factors have also been found to be controlled by Ca(++) signals. Moreover, pre-mRNA elements have been identified that are essential and sufficient to mediate Ca(++)-regulated splicing, providing model systems for dissecting the involved molecular components. In neurons, this regulation likely contributes to the fine-tuning of neuronal properties.
Xie
Jiuyong
J
Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Canada MB R3E 3J7. xiej@cc.umanitoba.ca
D017398:Alternative Splicing / Q000235:genetics / Q000502:physiology*; D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D005091:Exons; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000502:physiology*; D012322:RNA Precursors / Q000235:genetics / Q000502:physiology*
D012322:RNA Precursors