[Gene-diet interactions in atherogenic dyslipidemias (part 2)].
In the second part of the review, functional polymorphisms of some other lipid-related genes are considered, with a special emphasis on genetic variability of the fatty acid binding protein, lipoprotein lipase, hepatic lipase, and PPARs. Gene polymorphisms can profoundly influence metabolic responses to various dietary factors, e.g. effects of a special diet; on the other hand, dietary habits have modulatory effects on the expression of specific genotypes. Atherosclerosis and cardiovascular disease develop as a result of negative nutritional factors and individual genetic predisposition. A better comprehension of complex gene-gene and gene-environment interactions involved in cardiovascular risk could contribute to new preventive and therapeutic methods.
Zák
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IV. interní klinika 1. LF UK a VFN, Praha. azak@vfn.cz
Slabý
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D050197:Atherosclerosis / Q000235:genetics*; D004032:Diet; D050171:Dyslipidemias / Q000235:genetics*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics; D011110:Polymorphism, Genetic
D050556:Fatty Acid-Binding Proteins; D047492:Peroxisome Proliferator-Activated Receptors