A confusion in antibody identification: anti-D production after anti-hrB.
It is well known that certain combinations of alloantibodies are frequently found together. Patients with sickle cell disease (SCD) are mostly ofAfrican ancestry,and they may make anti-hrB. A transfusion of hrB- blood is often achieved by using e- (R2R2) RBCs; it is generally believed that hrB- patients readily make anti-E or a"broad-spectrum" anti-Rh34 (-HrB). We describe two multiply transfused D+ patients with SCD and a history of anti-hrB who subsequently produced anti- D. This raises the question whether anti-hrB together with anti-D is a more common antibody combination than anti-hrB with anti-E or anti-Rh34.
Lomas-Francis
C
C
Laboratory of Immunohematology, New York Blood Center, New York, NY, USA.
Yomtovian
R
R
McGrath
C
C
Walker
P S
PS
Reid
M E
ME
D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy; D044383:Black People / Q000235:genetics; D001787:Blood Group Incompatibility / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000172:deficiency; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis / Q000097:blood* / Q000302:isolation & purification*; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000276:immunology*; D018029:Rho(D) Immune Globulin; D018805:Sepsis / Q000097:blood / Q000628:therapy; D065227:Transfusion Reaction; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000097:blood / Q000628:therapy
D006454:Hemoglobins; D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin