[Effect of preoperative transcatheter arterial chemo-embolization on activity of cell proliferation in Wilms; tumor].
To investigate the effect of preoperative transcatherter arterial chemo-embolization (TACE) on the cell proliferation in Wilms; tumor.



Forty-one cases of Wilms; tumor diagnosed by histopathology were divided into two groups: in TACE group, 23 patients received TACE first and were operated 2 weeks later; in control group, 18 patients were operated alone. A comparative analysis of the pathological finding was made in two groups, and the expression of PCNA and VEGF in tumor tissue was detected by immunohistochemistry.



The degeneration of tumor tissue such as tumor cell necrotic, broken, disappearance occurred in 17 cases of TACE group and in 4 cases of control group, respectively (P <0.01). The expression of PCNA in TACE group and in control group was 1/23 (4.3 %) and 9/18(50.0 %), respectively (P <0.01). VEGF was expressed in 7/23 (30.4 %) of TACE group and 9/18 (50.0 %) of control group (P=0.283).



TACE can significantly inhibit proliferation and enhance degeneration of Wilms; tumor cells.
Liu
Wei-guang
WG
The Affiliated Children's Hospital, College of Medcine, Zhejiang University, Hangzhou 310003, China.
Gu
Wei-zhong
WZ
Zhou
Yin-bao
YB
Tang
Hong-feng
HF
Li
Min-ju
MJ
D049109:Cell Proliferation; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D011300:Preoperative Care; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D009396:Wilms Tumor / Q000150:complications* / Q000473:pathology* / Q000601:surgery / Q000628:therapy
D018809:Proliferating Cell Nuclear Antigen; D042461:Vascular Endothelial Growth Factor A