C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.
We investigated the association between the MDR1 C3435T polymorphism and P-glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with AML, excluding the M3 subtype. The CC, CT and TT genotype frequencies of the C3435T polymorphism among patients were 71, 93 and 36, respectively. The C3435T polymorphism genotypes did not have influence on the P-glycoprotein function of leukemic blasts. Complete remission rates and overall, relapse-free and event-free survival rates were not significantly different among the C3435T polymorphism genotypes. In conclusion, the MDR1 C3435T polymorphism does not appear to have significant clinical implications in AML.
Hur
Eun-Hye
EH
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-2dong, Songpa-ku, Seoul, Republic of Korea.
Lee
Je-Hwan
JH
Lee
Michael Jinpyo
MJ
Choi
Seong-Jun
SJ
Lee
Jung-Hee
JH
Kang
Mun Jung
MJ
Seol
Miee
M
Jang
Yae Eun
YE
Lee
Hee-Jung
HJ
Kang
Ip-Sol
IS
Shim
Soo-Kyung
SK
Ryu
Seong-Gil
SG
Kang
Young-Ah
YA
Lee
Young-Shin
YS
Park
Chan-Jeoung
CJ
Chi
Hyun-Sook
HS
Lee
Kyoo-Hyung
KH
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D005260:Female; D019450:Genes, MDR; D005838:Genotype; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016019:Survival Analysis; D016896:Treatment Outcome
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1