Short- and long-term effects of bacterial gastrointestinal infections.
During 1997-2004, microbiologically confirmed gastrointestinal infections were reported for 101,855 patients in Sweden. Among patients who had Salmonella infection (n = 34,664), we found an increased risk for aortic aneurysm (standardized incidence ratio [SIR] 6.4, 95% confidence interval [CI] 3.1-11.8) within 3 months after infection and an elevated risk for ulcerative colitis (SIR 3.2, 95% CI 2.2-4.6) within 1 year after infection. We also found this elevated risk for ulcerative colitis among Campylobacter infections (n = 57,425; SIR 2.8, 95% CI 2.0-3.8). Within 1 year, we found an increased risk for reactive arthritis among patients with Yersinia enteritis (n = 5,133; SIR 47.0, 95% CI 21.5-89.2), Salmonella infection (SIR 18.2, 95% CI 12.0-26.5), and Campylobacter infection (SIR 6.3, 95% CI 3.5-10.4). Acute gastroenteritis is sometimes associated with disease manifestations from several organ systems that may require hospitalization of patients.
Ternhag
Anders
A
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. anders.ternhag@karolinska.se
Törner
Anna
A
Svensson
Ake
A
Ekdahl
Karl
K
Giesecke
Johan
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001014:Aortic Aneurysm / Q000150:complications; D016918:Arthritis, Reactive / Q000453:epidemiology; D002169:Campylobacter Infections / Q000150:complications / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D005759:Gastroenteritis / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012480:Salmonella Infections / Q000150:complications / Q000453:epidemiology*; D013548:Sweden / Q000453:epidemiology; D013995:Time; D015009:Yersinia Infections / Q000150:complications / Q000453:epidemiology*