Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.
We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum-infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability. The follow-up of such patients should be strengthened.
Durand
Rémy
R
Hôpital Avicenne, Bobigny, France. remy.durand@avc.aphp.fr
Prendki
Virginie
V
Cailhol
Johann
J
Hubert
Véronique
V
Ralaimazava
Pascal
P
Massias
Laurent
L
Bouchaud
Olivier
O
Le Bras
Jacques
J
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D053626:Atovaquone / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000008:administration & dosage / Q000627:therapeutic use; D017211:Treatment Failure
D000962:Antimalarials; D002727:Proguanil; D053626:Atovaquone