Isolation and characterization of new Cannabis constituents from a high potency variety.
Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (+/-)-6,7-trans-epoxycannabigerolic acid ( 2), (+/-)-6,7- CIS-epoxycannabigerolic acid ( 3), (+/-)-6,7- CIS-epoxycannabigerol ( 4), (+/-)-6,7-trans-epoxycannabigerol ( 5), 5'-methyl-4-pentylbiphenyl-2,2',6-triol ( 7), and 7-methoxycannabispirone ( 8), along with seven known compounds namely, cannabigerolic acid ( 1), 5'-methoxycannabigerolic acid ( 6), cannabispirone ( 9), beta-cannabispiranol ( 10), dehydrocannabifuran ( 11), cannflavin B ( 12) and cannabigerol ( 13). The antimicrobial as well as the antileishmanial activities were investigated.
Radwan
Mohamed M
MM
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Ross
Samir A
SA
Slade
Desmond
D
Ahmed
Safwat A
SA
Zulfiqar
Fazila
F
Elsohly
Mahmoud A
MA
D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis*; D002188:Cannabis / Q000737:chemistry*; D002522:Chlorocebus aethiops; D007893:Leishmania donovani / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy*; D019906:Nuclear Magnetic Resonance, Biomolecular; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018675:Toxicity Tests; D014709:Vero Cells
D000890:Anti-Infective Agents; D010936:Plant Extracts