title: A case of suspected contact dermatitis in a juvenile cynomolgus monkey (Macaca fascicularis).
abstract: BACKGROUND
  A 2-year-old male cynomolgus monkey (Macaca fascicularis) presented with vesicular dermatitis exhibiting freshly ruptured blisters, crusts, and papules on the extremities and face.
  
  
  METHODS
  Complete blood count, serum chemistry, skin biopsy, skin scrape, and culture of a fresh blister were initially submitted for diagnostics.
  
  
  RESULTS
  Skin biopsy of the affected area revealed a non-suppurative eosinophilic dermatitis with mild thickening of the epidermis. Serum chemistry showed a marked eosinophilia (1.74 x 10(3)/microl, 17.4%). All other results were within normal limits. Initial differentials included contact dermatitis, immune-mediated disease such as pemphigus or psoriasis. Repeated blood work and skin biopsies were collected as well as serum for allergen-specific IgE latex and food allergy testing. Herpes B virus was added to the differential list after an oral lesion was noted upon repeated physical examination and samples were collected for testing. Repeat blood work maintained a marked eosinophilia and food allergy testing was within normal limits. Serum IgE for latex was equivocal and a follow-up latex sensitivity test was performed and was within normal limits. Repeated skin biopsies were consistent with acute eosinophilic spongiotic dermatitis with vesicles most likely due to contact dermatitis. No therapy was initiated during the diagnostic period and no etiology was confirmed.
  
  
  CONCLUSIONS
  Over time the dermatitis and eosinophilia resolved spontaneously. The animal is currently free of any lesions and maintains an eosinophil count within normal limits.
authors.affiliation: Department of Laboratory Animal Science, GlaxoSmithKline, 709 Swedeland Road UW 2630, King of Prussia, PA 19406, USA. joanne.b.morris@gsk.com
authors.forename: Joanne
authors.initials: J
authors.lastname: Morris
authors.forename: Marcia
authors.initials: M
authors.lastname: Etheridge
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D004802:Eosinophilia / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology