Nasal NK/T-cell lymphoma: epidemiology and pathogenesis.
Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein-Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-KIT, revealed the different frequencies by district. Epidemiological studies revealed the changes of the disease frequency in Korea during the period from 1977-1989 to 1990-1996. Case-control study showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.
Aozasa
Katsuyuki
K
Department of Pathology (C3), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. aozasa@molpath.med.osaka-u.ac.jp.
Takakuwa
Tetsuya
T
Department of Pathology (C3), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hongyo
Tadashi
T
Department of Radiation Biology, Osaka University Graduate School of Medicine, Osaka, Japan.
Yang
Woo-Ick
WI
Department of Pathology, College of Medicine, Yonsei University, Seoul, South Korea.
D001208:Asia / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects; D020031:Epstein-Barr Virus Infections / Q000150:complications; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology* / Q000821:virology; D007843:Latin America / Q000453:epidemiology; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D009669:Nose Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D010573:Pesticide Residues / Q000009:adverse effects; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
D010573:Pesticide Residues; D019009:Proto-Oncogene Proteins c-kit