title: Prediction of placental abruption by testing for C-reactive protein and chlamydial antibody levels in early pregnancy.
abstract: OBJECTIVE
  Placental abruption may be a manifestation of acute and chronic inflammatory process. We wanted to assess the association of first-trimester serum C-reactive protein (CRP), Chlamydia pneumoniae antibodies, Chlamydia trachomatis antibodies or chlamydial heat-shock protein 60 (CHSP60) antibodies to placental abruption.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  A total of 181 women with subsequent placental abruption and 261 control women with normal pregnancy.
  
  
  METHODS
  Serum samples collected at first trimester (mean 10.4 gestational weeks) were analysed for CRP levels, C. pneumoniae-specific immunoglobulin G (IgG) and immunoglobulin A (IgA) antibodies and C. trachomatis-specific IgG, IgA and CHSP60 antibodies.
  
  
  METHODS
  Placental abruption.
  
  
  RESULTS
  The levels of CRP showed no difference between the cases and the controls (median 2.35 mg/l [interquartile range {IQR} 1.09-5.93] versus 2.28 mg/l [IQR 0.92-5.01], not significant). C. pneumoniae-specific IgG and IgA as well as C. trachomatis-specific IgG, IgA and CHSP60 antibody frequencies were similar between the groups. There was no association between CRP levels and chlamydial antibodies.
  
  
  CONCLUSIONS
  These markers of inflammation in early pregnancy failed to predict subsequent placental abruption.
authors.affiliation: Department of Obstetrics and Gynaecology, University Central Hospital, Helsinki, Finland. minna.tikkanen@hus.fi
authors.forename: M
authors.initials: M
authors.lastname: Tikkanen
authors.forename: H-M
authors.initials: HM
authors.lastname: Surcel
authors.forename: A
authors.initials: A
authors.lastname: Bloigu
authors.forename: M
authors.initials: M
authors.lastname: Nuutila
authors.forename: V
authors.initials: V
authors.lastname: Hiilesmaa
authors.forename: O
authors.initials: O
authors.lastname: Ylikorkala
authors.forename: J
authors.initials: J
authors.lastname: Paavonen
mesh_terms: D000037:Abruptio Placentae / Q000175:diagnosis*; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000175:diagnosis*; D002692:Chlamydia trachomatis / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D002097:C-Reactive Protein