Libman-Sacks endocarditis and cerebral embolization in antiphospholipid syndrome.
In antiphospholipid syndrome (APS), there is a high prevalence of valvular heart disease which leads to increased risk of thrombo-embolic events, in particular, cerebrovascular events. We present a patient with cerebral infarction, previous deep-vein thrombosis, and miscarriages with positive lupus anticoagulant and anticardiolipin antibodies. Echocardiographic examination revealed mitral valve leaflet thickening and verrucous vegetations consistent with Libman-Sacks endocarditis, which is commonly associated with APS. In patients with combined Libman-Sacks endocarditis and antiphospholipid antibodies, anticoagulation therapy with warfarin is indicated due to high risk of valvular thrombus formation and subsequent embolization.
Lønnebakken
Mai Tone
MT
Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway. mai.tone.lonnebakken@helse-bergen.no
Gerdts
Eva
E
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002544:Cerebral Infarction / Q000209:etiology; D004696:Endocarditis / Q000150:complications / Q000209:etiology*; D005260:Female; D006801:Humans; D020766:Intracranial Embolism / Q000209:etiology* / Q000517:prevention & control; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D020246:Venous Thrombosis; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin