title: Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation.
abstract: Modified adenosine derivatives may lead to the development of P2Y(12) antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2',3'-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5'-position. The resulting analogues were tested for P2Y(12) antagonism in a platelet aggregation assay.
authors.affiliation: Inspire Pharmaceuticals, Inc., Department of Medicinal Chemistry, 4222 Emperor Boulevard, Suite 200, Durham, NC 27703, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Douglass
authors.forename: J Bryan
authors.initials: JB
authors.lastname: deCamp
authors.forename: Emilee H
authors.initials: EH
authors.lastname: Fulcher
authors.forename: William
authors.initials: W
authors.lastname: Jones
authors.forename: Sanjoy
authors.initials: S
authors.lastname: Mahanty
authors.forename: Anna
authors.initials: A
authors.lastname: Morgan
authors.forename: Dima
authors.initials: D
authors.lastname: Smirnov
authors.forename: José L
authors.initials: JL
authors.lastname: Boyer
authors.forename: Paul S
authors.initials: PS
authors.lastname: Watson
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D058919:Purinergic P2 Receptor Antagonists; D058925:Receptors, Purinergic P2Y12
chemical_list: D008565:Membrane Proteins; C548576:P2RY12 protein, human; D058919:Purinergic P2 Receptor Antagonists; D058925:Receptors, Purinergic P2Y12; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate