Combination chemoprevention of hamster buccal pouch carcinogenesis by bovine milk lactoferrin and black tea polyphenols.
Combination chemoprevention is a promising approach for oral cancer prevention. The authors evaluated the combined chemopreventive effects of bovine milk lactoferrin (bLF) and black tea polyphenols (Polyphenon-B) in a clinically relevant in vivo model of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. Although dietary administration of bLF and Polyphenon-B alone significantly reduced the tumor incidence, combined administration of bLF and polyphenon-B was more effective in inhibiting DMBA-induced genotoxicity and development of HBP carcinomas by modulation of carcinogen-metabolizing enzymes and cellular redox status. These results suggest that a "designer item" approach will be useful for human oral cancer prevention strategies.
Mohan
K V P Chandra
KV
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Letchoumy
P Vidjaya
PV
Hara
Y
Y
Nagini
S
S
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002417:Cattle; D002610:Cheek; D018890:Chemoprevention; D006224:Cricetinae; D004359:Drug Therapy, Combination; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007781:Lactoferrin / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D008647:Mesocricetus; D015162:Micronucleus Tests; D008892:Milk; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D013662:Tea; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D002273:Carcinogens; D010636:Phenols; D013662:Tea; D017392:Thiobarbituric Acid Reactive Substances; C506663:polyphenon B; D015127:9,10-Dimethyl-1,2-benzanthracene; D005979:Glutathione Peroxidase; D016660:NAD(P)H Dehydrogenase (Quinone); D005980:Glutathione Reductase; D005982:Glutathione Transferase; D007781:Lactoferrin; D005978:Glutathione