Ophthalmic light sensitive nanocarrier systems.
The eye is afflicted by chronic vision debilitating neovascular disorders, such as age-related macular degeneration, proliferative diabetic retinopathy, and corneal angiogenesis. Photodynamic therapy (PDT) is an innovative, evolving approach for treating neovascular diseases of the eye. PDT refers to the process of activating a light sensitive agent or carrier with non-thermal light to induce chemical reactions that ameliorate a pathological condition. Key components of PDT include a photosensitizer, a colloidal carrier or formulation and a light source. This article summarizes currently available clinical PDTs, desirable features of PDTs and photosensitizers, useful light sources for PDT and investigational nanosystems, and colloidal carriers for PDT.
Christie
Jennifer G
JG
Department of Pharmaceutical Sciences, 985840 Nebraska Medical Center, Omaha, NE 68198-5840, United States.
Kompella
Uday B
UB
D002908:Chronic Disease; D004337:Drug Carriers / Q000737:chemistry; D005128:Eye Diseases / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008953:Models, Anatomic; D049329:Nanostructures / Q000737:chemistry*; D010778:Photochemotherapy / Q000295:instrumentation / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*
D004337:Drug Carriers; D017319:Photosensitizing Agents