[Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method].
OBJECTIVE
To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata.


METHODS
An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets.


RESULTS
The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets.


CONCLUSIONS
It can enhance the bioavailability of PF by made it to pellets.
Jia
Xiao-bin
XB
Jiangsu Academy of Chinese Medicine Sciences, Jiangsu Engineering and Technology Research Center for Modern Chinese Pharmaceutical Preparation, Nanjing 210028, China.
Cai
Yin
Y
Chen
Yan
Y
Cheng
Xu-dong
XD
Fan
Chen-yi
CY
Shi
Ya-fang
YF
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D007529:Isoflavones / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008863:Microspheres; D018517:Plant Roots / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
D000975:Antioxidants; D005419:Flavonoids; D007529:Isoflavones; D013607:Tablets; C511199:yufengningxin