[Treatment of idiopathic hypereosinophilic syndrome with imatinib].
We here report a case of idiopathic hypereosinophilic syndrome with prompt response to treatment with imatinib. The patient presented with chest pain, myalgias, fatigue and weakness. Blood tests and bone marrow examination revealed striking eosinophilia. Clonal or reactive disorders were excluded by a wide range of diagnostic examinations. Treatment with high-dosis corticosteroids and hydroxyurea had little effect. Additional treatment with imatinib resulted in prompt symptomatic improvement and full haematological remission within five days of therapy.
Sørensen
Anne Louise
AL
2 Lamson Place Apt #3, Cambridge, MA-02139, USA. als@dadlnet.dk.
Larsen
Herdis
H
D001549:Benzamides; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy*; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate