Vertebrate genomes code excess proteins with charge periodicity of 28 residues.
All amino acid sequences derived from 248 prokaryotic genomes, 10 invertebrate genomes (plants and fungi) and 10 vertebrate genomes were analysed by the autocorrelation function of charge sequences. The analysis of the total amino acid sequences derived from the 268 biological genomes showed that a significant periodicity of 28 residues is observable for the vertebrate genomes, but not for the other genomes. When proteins with a charge periodicity of 28 residues (PCP28) were selected from the total proteomes, we found that PCP28 in fact exists in all proteomes, but the number of PCP28 is much larger for the vertebrate proteomes than for the other proteomes. Although excess PCP28 in the vertebrate proteomes are only poorly characterized, a detailed inspection of the databases suggests that most excess PCP28 are nuclear proteins.
Ke
Runcong
R
Department of Applied Physics, Graduate School of Engineering, Nagoya University, Nagoya, Japan. ke@bp.nuap.nagoya-u.ac.jp
Sakiyama
Noriyuki
N
Sawada
Ryusuke
R
Sonoyama
Masashi
M
Mitaku
Shigeki
S
D000818:Animals; D016678:Genome; D006801:Humans; D051379:Mice; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics; D016366:Open Reading Frames; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D020543:Proteome / Q000737:chemistry; D020539:Sequence Analysis, Protein; D014714:Vertebrates / Q000235:genetics*; D016335:Zinc Fingers
D009687:Nuclear Proteins; D011506:Proteins; D020543:Proteome