title: Short-term improvement of erectile dysfunction by viewing humorous films in patients with atopic dermatitis.
abstract: BACKGROUND
  Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by eczema, pruritus and cutaneous hyperreactivity to allergic triggers. We and others have reported that psychogenic stress aggravates these symptoms, while viewing humorous films alleviates them. We have also found that many AD patients suffer from erectile dysfunction (ED). ED exhibits multifactorial etiologies, including psychogenic stress and reduction of serum testosterone levels.
  
  
  OBJECTIVE
  This study assessed the effects of viewing humorous films on ED in patients with AD.
  
  
  METHODS
  The effects of viewing humorous films on International Index Erectile Function (IIEF) domain (erectile function, orgasmic function, sexual desire, intercourse satisfaction, overall satisfaction) were studied.
  
  
  METHODS
  Subjects comprised 36 AD patients with ED and their healthy wives. Randomly assigned 18 patients and their healthy wives first viewed humorous films on three consecutive days (Days 1-3). After 2 weeks, they viewed control nonhumorous weather information films on three consecutive days (Days 1-3). Alternatively, other 18 patients and their wives first viewed control films on three consecutive days, and after 2 weeks they viewed humorous films on three consecutive days. Severity of ED and serum testosterone and estradiol levels were assessed 1 day before viewing (Day -1) and 1-4 days after viewing (Days 4-7).
  
  
  RESULTS
  Viewing humorous films significantly improved the IIEF domain in association with increased serum testosterone levels and decreased serum estradiol levels on Day 4, while viewing control films failed to do so. However, this effect was short-term. After 4 days of viewing (Day 7), no improvement in ED or modulation of serum sex hormone levels was observed.
  
  
  CONCLUSIONS
  Viewing humorous films improved ED in AD patients in association with increased serum testosterone levels and decreased serum estradiol levels. These results may be useful for the study and treatment of ED.
authors.affiliation: Department of Allergy, Moriguchi-Keijinkai Hospital, Moriguchi City, Osaka Prefecture, Japan. kimata-keijinkai@mkc.zaa.ne.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Kimata
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000097:blood / Q000523:psychology / Q000628:therapy*; D007172:Erectile Dysfunction / Q000523:psychology / Q000628:therapy*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007989:Libido; D008297:Male; D009040:Motion Pictures; D017060:Patient Satisfaction; D013739:Testosterone / Q000097:blood; D014925:Wit and Humor as Topic
chemical_list: D013739:Testosterone; D004958:Estradiol