[Protective properties of the immunomodulator Gala-Vet in a complex with cellular Echinococcus multilocularis antigen in experimental hydatidosis].
The paper provides the results of studying the protective properties of the immunomodulator Gala-Vet alone and in combination with the cellular antigens of Echinococcus multiocularis protoscolexes in experimental murine hydatidosis. After checking inoculation with E. multilocularis protoscolexes and acephalocysts (a dose being 750+/-50 specimens), the protective efficiency in the mice immunized with the cellular antigen subcutaneously injected thrice in a dose of 60 micromg was 91.7%. In the mice immunized with the cellular antigen of parasitic protoscolexes in the same dose in the same manner, the protective effect was 75%. The similar protective effect (75%) was recorded in the group of mice receiving the immunomodulator Gala-Vet alone. After inoculation and slaughter, all the control mice administered a sterile physiological solution in the immunization period were infested.
Sasikova
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Berezhko
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D000818:Animals; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000378:metabolism; D002478:Cells, Cultured; D004443:Echinococcosis / Q000517:prevention & control*; D048210:Echinococcus multilocularis / Q000276:immunology* / Q000378:metabolism; D015801:Helminth Proteins / Q000008:administration & dosage* / Q000378:metabolism; D007115:Immunization Schedule; D007155:Immunologic Factors / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D051379:Mice; D014611:Vaccination
D000947:Antigens, Helminth; D015801:Helminth Proteins; D007155:Immunologic Factors