title: [Significance of various methods of assessment of functional state for cardiovascular risk stratification].
abstract: Arterial hypertension (AH) combined with diabetes mellitus accelerates development of damage of the kidney. Elevation of serum creatinine level, lowering of creatinine clearance or calculated glomerular filtration rate (GFR), microalbuminuria are independent prognostic factors of cardiovascular morbidity and mortality. Unfavorable outcomes of impaired renal function can be prevented or delayed with the help of appropriate interventions at early stages. There is an urgency to search for methods allowing to reveal in patients with cardiovascular diseases impairment of renal function at preclinical stages. In all patients with AH estimation of GFR using MDRD equation or creatinine clearance using Cockcroft-Gault formula as well as measurement of urinary protein excretion are necessary. The given article presents review of available literature data devoted to the problem of contemporary methods of early preclinical detection of renal damage.
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Kobalava
authors.forename: S V
authors.initials: SV
authors.lastname: Villeval'de
authors.forename: V S
authors.initials: VS
authors.lastname: Moiseev
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D003404:Creatinine / Q000378:metabolism*; D014943:Global Health; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009017:Morbidity; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D003404:Creatinine