Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57.
In order to search for structurally novel and bioactive natural compounds from microorganisms, a halotolerant fungal strain, Penicillium citrinum B-57, which mainly produces citrinin derivatives, was isolated from sediments collected from the Jilantai salt field. From the ethyl acetate extract of P. citrinum B-57, two new citrinin dimers, pennicitrinone C ( 1) and penicitrinol B ( 2), and 11 known related compounds were isolated and identified by spectroscopic and chemical methods. These compounds showed antioxidative activity against DPPH radicals with IC 50 values ranging from 0.8 to 59 microM.
Lu
Zhen-Yu
ZY
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Lin
Zhen-Jian
ZJ
Wang
Wen-Liang
WL
Du
Lin
L
Zhu
Tian-Jiao
TJ
Fang
Yu-Chun
YC
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002681:China; D002953:Citrinin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010851:Picrates / Q000494:pharmacology
D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; C529464:penicitrinol B; C529463:pennicitrinone C; D002953:Citrinin; C004931:1,1-diphenyl-2-picrylhydrazyl