Multiple newly identified loci associated with prostate cancer susceptibility.
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at </=60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 x 10(-8) to P = 8.7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.
Eeles
Rosalind A
RA
The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK. rosalind.eeles@icr.ac.uk
Kote-Jarai
Zsofia
Z
Giles
Graham G
GG
Olama
Ali Amin Al
AA
Guy
Michelle
M
Jugurnauth
Sarah K
SK
Mulholland
Shani
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Leongamornlert
Daniel A
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Edwards
Stephen M
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Morrison
Jonathan
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Field
Helen I
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Southey
Melissa C
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Severi
Gianluca
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Donovan
Jenny L
JL
Hamdy
Freddie C
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Dearnaley
David P
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Muir
Kenneth R
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Smith
Charmaine
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Bagnato
Melisa
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Ardern-Jones
Audrey T
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Hall
Amanda L
AL
O'Brien
Lynne T
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Gehr-Swain
Beatrice N
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Wilkinson
Rosemary A
RA
Cox
Angie
A
Lewis
Sarah
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Brown
Paul M
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Jhavar
Sameer G
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Tymrakiewicz
Malgorzata
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Lophatananon
Artitaya
A
Bryant
Sarah L
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Horwich
Alan
A
Huddart
Robert A
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Khoo
Vincent S
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Parker
Christopher C
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Woodhouse
Christopher J
CJ
Thompson
Alan
A
Christmas
Tim
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Ogden
Chris
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Fisher
Cyril
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Jamieson
Charles
C
Cooper
Colin S
CS
English
Dallas R
DR
Hopper
John L
JL
Neal
David E
DE
Easton
Douglas F
DF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001315:Australia; D016022:Case-Control Studies; D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D040641:Quantitative Trait Loci; D006113:United Kingdom