Neurocognition and conversion to psychosis in adolescents at high-risk.
This study examined neurocognitive predictors of conversion to Axis I psychosis among adolescents at high-risk for psychosis (AHRP). There were no significant differences in neurocognitive performance between adolescents at high-risk for psychosis who converted (AHRP+) and adolescents at high-risk for psychosis who did not convert (AHRP-). Within-sex comparisons revealed a relation between risk status and performance among females, with AHRP+ performing below AHRP-, but this effect did not hold for males. Between-sex comparisons revealed AHRP- males performed worse than AHRP- females on several measures. Across groups, males performed better than their female counterparts on select measures. Results are discussed in terms of implications for use of neurocognitive profiles as bio-risk markers of psychosis, while considering sex differences.
Walder
D J
DJ
Department of Psychology, Brooklyn College of The City University of New York, USA. dwalder@brooklyn.cuny.edu
Mittal
V
V
Trotman
H D
HD
McMillan
A L
AL
Walker
E F
EF
D000293:Adolescent; D016009:Chi-Square Distribution; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis*; D012307:Risk Factors; D012727:Sex Characteristics