Effects of treadmill exercise on hypoactivity of the hypothalamo-pituitary-adrenal axis induced by chronic administration of corticosterone in rats.
The stress response alters behavior, autonomic function and secretion of multiple hormones, including CRF, ACTH, and glucocorticoid, through the HPA axis. Consecutive stress exposures lead to HPA axis dysregulation such as hyperactivity in Alzheimer's disease and depression, and hypoactivity in post-traumatic stress disorder. In the present study, we established a model of hypoactivated HPA axis in rat through chronic administration of corticosterone (40mg/kg, s.c.) for 19 consecutive days. In this model, CRF mRNA expression in the hypothalamus and ACTH levels in serum were significantly decreased by chronic administration of corticosterone. In addition, the effect of treadmill exercise was investigated in our hypoactivated HPA axis rat model. Treadmill exercise recovered the dysregulated hypoactivity of the HPA axis induced by corticosterone administration for 19 days. The results of the present study suggest that treadmill exercise may aid recovery of hypoactivated HPA axis dysregulation in psychological diseases such as post-traumatic stress disorder.
Kim
Hong Gi
HG
Department of Biological Science, Sungkyunkwan University, 300 Cheoncheon-Dong, Jangan-Gu, Suwon, Gyeonggi-Do 440-746, Republic of Korea.
Lim
Eun Young
EY
Jung
Woo Ram
WR
Shin
Min Kyoo
MK
Ann
Eue Soo
ES
Kim
Kil Lyong
KL
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002908:Chronic Disease / Q000628:therapy; D003345:Corticosterone / Q000008:administration & dosage* / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000235:genetics; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D010805:Physical Conditioning, Animal / Q000379:methods; D010900:Pituitary Diseases / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000150:complications*; D016896:Treatment Outcome
D012333:RNA, Messenger; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone