Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice.
In vivo studies of the effectiveness of various forms of calcium pterin reveal significant antitumor activity associated with (1:4, mol/mol) calcium pterin (CaPterin), (1:2, mol/mol) calcium pterin, dipterinyl calcium pentahydrate (DCP), as well as unexpectedly for a calcium chloride dihydrate solution in nude mice with MDA-MB-231 xenographs. Stepwise regression analysis of nine plasma cytokine and indoleamine 2,3-dioxygenase (IDO) metabolite levels identified four effects correlated to (1:4, mol/mol) calcium pterin administration: (1) decreased IL-6, (2) increased IL-10, (3) decreased IFN-gamma, and (4) increased kynurenine.


CONCLUSIONS
(1:4, mol/mol) CaPterin exerts significant (by Spearman rank order correlation) dose-response antitumor activity in nude mice with MDA-MB-231 xenographs, and sustains both inflammatory and anti-inflammatory changes in the levels of certain plasma factors.
Moheno
Phillip
P
SanRx Pharmaceuticals, Inc., 603 Colima Street, La Jolla, CA 92037, USA. phil.moheno@sanrx.com
Pfleiderer
Wolfgang
W
DiPasquale
Antonio G
AG
Rheingold
Arnold L
AL
Fuchs
Dietmar
D
D000818:Animals; D002118:Calcium / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D007737:Kynurenine / Q000097:blood; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D008968:Molecular Conformation; D011622:Pterins / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013535:Suspensions; D014183:Transplantation, Heterologous; D014364:Tryptophan / Q000097:blood
D016207:Cytokines; D007155:Immunologic Factors; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D011622:Pterins; D013535:Suspensions; D007737:Kynurenine; D014364:Tryptophan; D002118:Calcium