Annexin A1 in the brain--undiscovered roles?
Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions.
Solito
Egle
E
Imperial College London, Commonwealth Building, Hammersmith Hospital, DuCane Road, London, UK. e.solito@imperial.ac.uk
McArthur
Simon
S
Christian
Helen
H
Gavins
Felicity
F
Buckingham
Julia C
JC
Gillies
Glenda E
GE
D000818:Animals; D017305:Annexin A1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000378:metabolism / Q000502:physiology
D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D044042:Receptors, Formyl Peptide