title: Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection.
abstract: BACKGROUND
  Infection with the anthropophilic fungus Trichophyton tonsurans has spread among members of combat sports clubs and has become a serious public health problem in Japan and other countries. Infection usually provokes only a weak inflammatory response, and treatment compliance tends to be poor.
  
  
  OBJECTIVE
  To evaluate the hairbrush method and the treatment protocol described in the guidelines for T. tonsurans infection.
  
  
  METHODS
  The study subjects were 69 individuals with positive hairbrush culture from among 327 members of 12 judo clubs participating in the survey. (a) Subjects with no more than 4 colonies by the hairbrush method were treated with miconazole nitrate shampoo. (b) Subjects with 5 or more colonies were treated with (1) itraconazole at a dose of 100 mg/day for 6 weeks or at a dose of 400 mg/day for 1 week, or (2) terbinafine at a dose of 125 mg/day for 6 weeks or at a dose of 500 mg/day for 1 week. Treatment efficacy was monitored by the hairbrush method at 1.5 and 3 months after treatment.
  
  
  RESULTS
  Of the 46 subjects with 5 or more colonies isolated by the hairbrush method, 32 (69.6%) took itraconazole or terbinafine in compliance with their treatment schedules and were negative for T. tonsurans after treatment. Of the 23 subjects with 4 or fewer colonies, 15 (65.2%) were negative for T. tonsurans after treatment with miconazole nitrate shampoo.
  
  
  CONCLUSIONS
  The treatment protocol seems promising, but poor compliance is a problem with the oral treatment regimens. The shampoo therapy is only partially effective, with 35% of subjects remaining positive for T. tonsurans after this therapy. In order to eradicate this disease, we have renewed the guidelines for T. tonsurans infection.
authors.affiliation: Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Shiraki
authors.forename: Masataro
authors.initials: M
authors.lastname: Hiruma
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002648:Child; D006203:Hair Preparations; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D008825:Miconazole / Q000008:administration & dosage*; D009281:Naphthalenes / Q000008:administration & dosage*; D010349:Patient Compliance; D017410:Practice Guidelines as Topic; D000077291:Terbinafine; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology*; D014249:Trichophyton / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D006203:Hair Preparations; D009281:Naphthalenes; D017964:Itraconazole; D008825:Miconazole; D000077291:Terbinafine