title: Chebulagic acid is a potent alpha-glucosidase inhibitor.
abstract: Chebulagic acid, isolated form Terminalia chebula Retz, proved to be a reversible and non-competitive inhibitor of maltase with a K(i) value of 6.6 muM. The inhibitory influence of chebulagic acid on the maltase-glucoamylase complex was more potent than on the sucrase-isomaltase complex. The magnitude of alpha-glucosidase inhibition by chebulagic acid was greatly affected by its origin. These results show a use for chebulagic acid in managing type-2 diabetes.
authors.affiliation: Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Yi-Na
authors.initials: YN
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D051381:Rats
chemical_list: D001578:Benzopyrans; D004791:Enzyme Inhibitors; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; C076178:chebulagic acid