Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references.
Preparative chemical methods for the synthesis of 10 degradation or photodecomposition products of mestranol and ethinyl estradiol (EE) are described. The synthesized compounds are useful as reference materials and standards for pharmaceutical analysis of mestranol and EE as bulk chemical or in formulated product. New synthetic methods were presented and the known synthetic procedures were improved. Detailed structural characterization of the degradation or photodecomposition products of mestranol and EE and related compounds was reported.
Li
Hongqi
H
Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, PR China. hongqili@dhu.edu.cn <hongqili@dhu.edu.cn>
Song
Yanxi
Y
Peng
Xianfu
X
D004967:Estrogens / Q000138:chemical synthesis* / Q000737:chemistry; D004997:Ethinyl Estradiol / Q000138:chemical synthesis* / Q000737:chemistry; D008656:Mestranol / Q000138:chemical synthesis* / Q000737:chemistry
D004967:Estrogens; D004997:Ethinyl Estradiol; D008656:Mestranol