Proton pump-inhibiting drugs, calcium homeostasis, and bone health.
Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available without a prescription. Two recent studies have demonstrated increased hip fracture rates associated with PPI use. Theoretically, PPIs could impair intestinal calcium absorption resulting in increased rates of bone loss and a greater risk of fragility fracture.
Wright
Matthew J
MJ
The University of Connecticut, Department of Allied Health Sciences, Storrs, Connecticut 06269-2101, USA. matthew.j.wright@uconn.edu
Proctor
Deborah D
DD
Insogna
Karl L
KL
Kerstetter
Jane E
JE
D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D050723:Fractures, Bone / Q000139:chemically induced / Q000453:epidemiology; D006620:Hip Fractures / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D054328:Proton Pump Inhibitors; D002118:Calcium