title: Synthesis and bioevaluation of 22-hydroxyacuminatine analogs.
abstract: A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.
authors.affiliation: Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France.
authors.forename: François
authors.initials: F
authors.lastname: Grillet
authors.forename: Barbora
authors.initials: B
authors.lastname: Baumlová
authors.forename: Grégoire
authors.initials: G
authors.lastname: Prévost
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Constant
authors.forename: Sophie
authors.initials: S
authors.lastname: Chaumeron
authors.forename: Dennis C H
authors.initials: DC
authors.lastname: Bigg
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Greene
authors.forename: Alice
authors.initials: A
authors.lastname: Kanazawa
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004264:DNA Topoisomerases, Type I / Q000235:genetics; D006801:Humans; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: C508964:22-hydroxyacuminatine; D000970:Antineoplastic Agents; D007212:Indolizines; D011804:Quinolines; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I