title: Isoxazoles from 1,1-Disubstituted Bromoalkenes.
abstract: The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,5-disubstituted bromoisoxazoline intermediates that aromatize to the analogous isoxazoles through the loss of HBr.
authors.affiliation: Department of Chemistry, Jackson State University, Jackson, Mississippi 39217, USA.
authors.forename: Sureshbabu
authors.initials: S
authors.lastname: Dadiboyena
authors.forename: Jianping
authors.initials: J
authors.lastname: Xu
authors.forename: Ashton T
authors.initials: AT
authors.lastname: Hamme