title: Effect of a noninvasive ventilatory support during exercise of a program in pulmonary rehabilitation in patients with COPD.
abstract: BACKGROUND
  Breathlessness is the most common symptom limiting exercise in patients with chronic obstructive pulmonary disease (COPD). Exercise training can improve both exercise tolerance and health status in these patients, intensity of exercise being of key importance. Nevertheless, in these patients extreme breathlessness and/or peripheral muscle fatigue may prevent patients from reaching higher levels of intensity.
  
  
  OBJECTIVE
  This study was to determine whether inspiratory pressure support (IPS) applied during sub maximal exercise could enable individuals with severe but stable COPD to increase their exercise tolerance.
  
  
  METHODS
  Twelve subjects with severe stable COPD (mean (SD): age = 63(8.2) years; FEV1 = 0.89(0.42) L (34)% predicted; FEV1/FVC = 0.31(0.07) only nine subjects completed the study.
  
  
  METHODS
  Each subject completed ten sessions of cycling at 25%-50% of their maximum power without NIVS and another ten sessions using NIVS.
  
  
  RESULTS
  Dyspnea was measured using Borg scale. Subjects reached high levels of dyspnea 4.7 (1.81) during the sessions without NIVS vs low levels of dyspnea during the sessions using NIVS 1.3 (0.6). Exercise time during the sessions without NIVS and with NIVS was 19.37 (3.4) and 33.75 (9.5) min, respectively. Maximal workload during the sessions without NIVS and with NIVS was 27 (3.7) and 50 (10.5) watt, respectively.
  
  
  CONCLUSIONS
  We conclude that IPS delivered by nasal mask can improve exercise tolerance and dyspnea in stable severe COPD patients and hence this mode of ventilatory support may be useful in respiratory rehabilitation programs.
authors.affiliation: EDISS, Lyon, France. barakat.shahin@free.fr
authors.forename: Shahin
authors.initials: S
authors.lastname: Barakat
authors.forename: Germain
authors.initials: G
authors.lastname: Michele
authors.forename: Pascale
authors.initials: P
authors.lastname: Nesme
authors.forename: Viallet
authors.initials: V
authors.lastname: Nicole
authors.forename: Annat
authors.initials: A
authors.lastname: Guy
mesh_terms: D000368:Aged; D004417:Dyspnea; D015444:Exercise / Q000502:physiology*; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011175:Positive-Pressure Respiration; D029424:Pulmonary Disease, Chronic Obstructive / Q000534:rehabilitation*