Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males.
Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia. Altered superoxide dismutase (SOD) and increased lipid peroxidation, measured by the thiobarbituric acid reactive substances (TBARS), are increased in schizophrenia. The aim of this study was to determine the effects of clinical course and subtype on oxidative stress parameters. In this study, 68 male patients, classified according to DSM-IV schizophrenia subtypes and clinical course (partial remission, marked symptoms, and deteriorated), were studied, and TBARS and SOD measured. Mean serum SOD and mean serum TBARS concentrations were similarly not significantly different among different subtypes (paranoid, disorganized and undifferentiated). However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males.
Gama
Clarissa Severino
CS
Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil. csgama@yahoo.com
Salvador
Mirian
M
Andreazza
Ana Cristina
AC
Lobato
Maria Ines
MI
Berk
Michael
M
Kapczinski
Flavio
F
Belmonte-de-Abreu
Paulo Silva
PS
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D011237:Predictive Value of Tests; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D012720:Severity of Illness Index; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood; D000072105:Superoxide Dismutase-1; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
D014150:Antipsychotic Agents; D015415:Biomarkers; C000606290:SOD1 protein, human; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1