title: Outcomes after laparoscopic Nissen fundoplication are not influenced by the pattern of reflux.
abstract: The purpose of this study was to compare the outcomes of patients with different types of gastroesophageal reflux disease (upright, supine, or bipositional) after laparoscopic Nissen fundoplication and determine if patients with upright reflux have worse outcomes. Two hundred and twenty-five patients with reflux confirmed by 24-h pH monitoring were divided into three groups based on the type of reflux present. Patients were questioned pre- and post-fundoplication regarding the presence and duration of symptoms (heartburn, regurgitation, dysphagia, cough and chest pain). Symptoms were scored using a 5-point scale, ranging from 0 (no symptom) to 4 (disabling symptom). Esophageal manometry and pH results were also compared. There was no statistically significant difference in lower esophageal sphincter length, pressure or function between the three groups. There was no significant difference in any of the postoperative symptom categories between the three groups. The type of reflux identified preoperatively does not have an adverse effect on postoperative outcomes after Nissen fundoplication and should not discourage physicians from offering antireflux surgery to patients with upright reflux.
authors.affiliation: Department of Surgery and Swallowing Center, University of California San Francisco, San Francisco, California 94143-0790, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Meneghetti
authors.forename: P
authors.initials: P
authors.lastname: Tedesco
authors.forename: C
authors.initials: C
authors.lastname: Galvani
authors.forename: M V
authors.initials: MV
authors.lastname: Gorodner
authors.forename: M G
authors.initials: MG
authors.lastname: Patti
mesh_terms: D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000145:classification / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome