title: [Combination of operation, chemotherapy and radiation for AFP producing gastric cancer--a case report].
abstract: We report a case of AFP producing gastric cancer after a combination of operation, chemotherapy and radiation. A 70-year-old man was admitted complaining of abdominal fullness. He was diagnosed as having type 3 advanced gastric cancer with multiple lymph node metastasis, including No. 8p lymph node, by endoscopy and computed tomography. Distal gastrectomy and D2 lymph node dissection were performed after chemotherapy using S-1, low-dose CDDP and CPT-11. Histopathological study showed moderately differentiated adenocarcinoma, and immunohistochemical study revealed a few AFP-positive tumor cells. Postoperatively, radiation (50 Gy) was performed for paraaortic lymph node metastasis and right hepatic lobectomy for liver metastasis. However, about 2 months after hepatic lobectomy, liver metastasis was diagnosed again by computed tomography, and radiation (30 Gy) was performed. He died 13 months after first surgery.
authors.affiliation: Federation of Public Services and Affiliated Personnel Aid Associations, Dept. of Surgery, Hiroshima Memorial Hospital.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Shiro
authors.initials: S
authors.lastname: Nakai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Morifuji
authors.forename: Mikio
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Katsunari
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Yokoyama
mesh_terms: D000368:Aged; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: C097353:AFP protein, human; D000509:alpha-Fetoproteins