Decoding the dynamics of T cell-dendritic cell interactions in vivo.
T lymphocytes receive activation signals during their encounters with antigen-bearing dendritic cells (DCs) in secondary lymphoid organs. With the recent application of two-photon imaging to visualize immune responses as they happen, the dynamics of T cell-DC interactions have been dissected in several mouse models. As we are integrating the results of these new studies, we are learning that the dynamics of T cell-DC interactions are regulated by multiple immunological parameters and, most importantly, that the spatiotemporal characteristics of these cell-cell contacts encode part of the T-cell fate.
Celli
Susanna
S
G5 Dynamiques des Réponses Immunes, Département d'Immunologie, Institut Pasteur, Paris, France.
Garcia
Zacarias
Z
Beuneu
Hélène
H
Bousso
Philippe
P
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens; D002450:Cell Communication / Q000276:immunology / Q000502:physiology*; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D000941:Antigens