Beta-arrestins: multifunctional cellular mediators.
Initially thought to play a role only in G-protein-coupled receptor desensitization, beta-arrestins are ascribed with new roles such as scaffolding and signaling proteins by their own right. This review explores the many functions of beta-arrestins, with an emphasis on their recently identified role as regulators of receptor signaling.
Barki-Harrington
Liza
L
Department of Biology, University of Haifa, Israel.
Rockman
Howard A
HA
D000818:Animals; D019390:Arrestins / Q000378:metabolism*; D004705:Endocytosis; D054768:G-Protein-Coupled Receptor Kinases / Q000378:metabolism; D006801:Humans; D008024:Ligands; D009206:Myocardium / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction; D000071557:beta-Arrestins
D019390:Arrestins; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D000071557:beta-Arrestins; D054768:G-Protein-Coupled Receptor Kinases