[Specifics of distribution of polymorphic markers of the renin-angiotensin-system genes, relation to ventricular hypertrophy in patients with essential hypertension of Uzbek nationality].
OBJECTIVE
To study distribution of polymorphisms of angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AT1R), aldosterone synthase (CYP11B2) genes, and their association with processes of left ventricular remodeling in men of uzbek nationality with essential hypertension (EH).


METHODS
Patients with stage 1-2 EH were genotyped for carrying I/D polymorphism of ACE gene, A1166C polymorphism of AT1R gene, and C(-344)T polymorphism of CYP11B2 gene. Echocardiography was used for measurement of left ventricular myocardial mass index.


CONCLUSIONS
Special features of distribution of studied genes among uzbek men were the following: accumulation of ID-genotype of I/D polymorphic marker of ACE gene among patients with EH, predominance of I-allele and II-genotype of ACE gene in healthy persons; accumulation of AA-genotype and A-allele of A1166C polymorphic marker of AT1R gene in patients with EH and healthy persons, while CC genotype was found only in patients with EH; predominance of CT genotype of C(-344)T polymorphic marker of CYP11B2 gene in patients with EH and healthy persons with high prevalence of T-allele in patients with EH. Carriage of TT genotype of C(-344)T polymorphic marker of CYP11B2 was associated with higher values of diastolic blood pressure. Associations were revealed between carriage of TT-genotype and T-allele of CYP11B2 gene, AC+CC-genotypes of AR1R gene and severity of left ventricular hypertrophy.
Khamidullaeva
G A
GA
Tashkent Center of Cardiology, Uzbekistan.
Eliseeva
M R
MR
Srozhiddinova
N Z
NZ
Abdullaeva
G Zh
GZh
D000328:Adult; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*; D012720:Severity of Illness Index; D014610:Uzbekistan / Q000453:epidemiology
D044140:Receptor, Angiotensin, Type 1; D019405:Cytochrome P-450 CYP11B2; D007703:Peptidyl-Dipeptidase A