title: Calcium bioavailability from a new calcium-fortified orange beverage, compared with milk, in healthy volunteers.
abstract: The recommended dietary calcium intake may be difficult to reach using dairy products only. This study aimed to evaluate the absorbability of calcium of a new orange beverage in comparison with that of milk. Ten healthy adults, 5 males and 5 females, were randomly divided to receive, under fasting conditions, an orange beverage enriched either with calcium or milk. Both the beverages had been labelled the previous evening with a 44Ca solution. After a two-month interval the subjects underwent a crossover of beverages. Total and ionized calcium, parathyroid (PTH) hormone, and 44Ca were evaluated. The 44Ca was measured by inductively coupled plasma spectrometry. The relative changes in calcium absorption from the two test drinks were similar (23.0 +/- 6.4% for milk and 20.9 +/- 9.1% for the orange beverage). No significant differences were found between the two test groups. Both milk and orange beverage determined a similar and significant (p < 0.001) decrease in serum PTH two hours after the beginning of the test (-22.1 +/- 14.0% for milk and -27.9 +/- 15.3% for orange beverage). We can conclude that the bioavailability of calcium from this new calcium-enriched orange beverage is similar to that of milk.
authors.affiliation: Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Italy. gonnelli@unisi.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Gonnelli
authors.forename: Maria S
authors.initials: MS
authors.lastname: Campagna
authors.forename: Andrea
authors.initials: A
authors.lastname: Montagnani
authors.forename: Carla
authors.initials: C
authors.lastname: Caffarelli
authors.forename: Alice
authors.initials: A
authors.lastname: Cadirni
authors.forename: Giorgio
authors.initials: G
authors.lastname: Giorgi
authors.forename: Ranuccio
authors.initials: R
authors.lastname: Nuti
mesh_terms: D000328:Adult; D000818:Animals; D001628:Beverages; D001682:Biological Availability; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D032084:Citrus sinensis; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008892:Milk / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D013223:Statistics as Topic
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium