Efficacy of a new formulation of amphotericin B in a murine model of disseminated infection by Candida glabrata.
OBJECTIVE
Amphotericin B poly-aggregates are a new formulation of amphotericin B, which can be obtained cheaply. In this study, we tested the efficacy of this new formulation for treating a disseminated infection by Candida glabrata in a murine model.


METHODS
Mice were rendered neutropenic by intraperitoneal cyclophosphamide and intravenous 5-fluorouracil administration and infected intravenously with 2 x 10(8) cfu of C. glabrata. The efficacy of the new formulation of amphotericin B was evaluated by survival and tissue burden studies. The experiments were repeated using three different clinical strains of C. glabrata.


CONCLUSIONS
Amphotericin B poly-aggregates showed an efficacy similar to that of amphotericin B deoxycholate and liposomal amphotericin B in the treatment of a disseminated murine infection by C. glabrata.
Mariné
Marçal
M
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
Espada
Raquel
R
Torrado
Juan
J
Pastor
F Javier
FJ
Guarro
Josep
J
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D041221:Candida glabrata / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology*; D002626:Chemistry, Pharmaceutical; D015169:Colony Count, Microbial; D007275:Injections, Intravenous; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D013154:Spleen / Q000382:microbiology; D016019:Survival Analysis
D000666:Amphotericin B