Biodegradation of aromatic compounds: an overview of meta-fission product hydrolases.
Meta fission product (MFP) hydrolases catalyze hydrolysis of a low reactive carbon-carbon bond found in meta-fission products, generated during biodegradation of various aromatic compounds. These enzymes belong to the alpha/beta hydrolase super family and show structural conservation despite having poor sequence similarity. MFP-hydrolases are substrate specific and studies have indicated that this substrate specificity plays a key role in the determination of the organism's ability to degrade a particular substrate. In this concise review of MFP-hydrolases we discuss their classification, biochemical properties, the molecular basis of their substrate specificity, their catalytic mechanism, and evolutionary significance.
Khajamohiddin
Syed
S
Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Repalle
Elisha Raju
ER
Pinjari
Aleem Basha
AB
Merrick
Mike
M
Siddavattam
Dayananda
D
D001711:Biotransformation; D006841:Hydrocarbons, Aromatic / Q000378:metabolism*; D006867:Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
D006841:Hydrocarbons, Aromatic; D006867:Hydrolases