The Hedgehog, TGF-beta/BMP and Wnt families of morphogens in axon guidance.
During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules and suggest that these proteins, rather than having sharply divergent functions, act more globally to provide graded positional information that can be interpreted by responding cells either to specify cell fate or to direct axonal pathfinding. This chapter presents the roles identified for members of three prominent morphogen families-the Hedgehog, Wnt and TGF-beta/BMP families-in axon guidance, and discusses potential implications for the molecular mechanisms underlying their guidance functions.
Charron
Frédéric
F
Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM), 110 Pine Ave West, Montreal, Quebec, H2W 1 R7, Canada. frederic.charron@ircm.qc.ca
Tessier-Lavigne
Marc
M
D000818:Animals; D001369:Axons / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D053823:Hedgehog Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D005810:Multigene Family / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology*
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins