title: Elevated cerebrospinal fluid and serum YKL-40 levels are not associated with symptomatic vasospasm in patients with aneurysmal subarachnoid haemorrhage.
abstract: YKL-40 is a newly discovered matrix protein that is thought to be released during the acute stages of inflammation. It has recently been speculated that YKL-40 may serve as a specific serological marker of neutrophil function at the site of tissue inflammation. Our aim was to determine whether the levels of YKL-40 in both the cerebrospinal fluid and sera of 22 patients with aneurysmal subarachnoid haemorrhage were associated with either vasospasm or outcome. The levels were also compared with those of 16 control patients with hydrocephalus. We found that patients with aneurysmal subarachnoid haemorrhage had significantly higher YKL-40 levels in both cerebrospinal fluid and serum than controls. However, elevated YKL-40 levels were not associated with symptomatic vasospasm or 6-month outcome. We show that elevated YKL-40 levels are not correlated with the severity of subarachnoid haemorrhage and cannot be used as a serological marker of inflammation in patients with an aneurysm rupture.
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Tibet
authors.initials: T
authors.lastname: Kacira
authors.forename: Hakan
authors.initials: H
authors.lastname: Hanimoglu
authors.forename: Mine
authors.initials: M
authors.lastname: Kucur
authors.forename: Galip Zihni
authors.initials: GZ
authors.lastname: Sanus
authors.forename: Ali Metin
authors.initials: AM
authors.lastname: Kafadar
authors.forename: Taner
authors.initials: T
authors.lastname: Tanriverdi
authors.forename: Mehmet Yasar
authors.initials: MY
authors.lastname: Kaynar
mesh_terms: D054392:Adipokines; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid; D002536:Cerebral Arteries / Q000378:metabolism / Q000503:physiopathology; D000071451:Chitinase-3-Like Protein 1; D004660:Encephalitis / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006023:Glycoproteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D037102:Lectins; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000150:complications; D013346:Subarachnoid Space / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D013997:Time Factors; D015854:Up-Regulation / Q000276:immunology; D020301:Vasospasm, Intracranial / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000150:complications
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins