title: Menisporopsin B, a new polyester from the seed fungus Menisporopsis theobromae BCC 4162.
abstract: A new linear polyester, menisporopsin B, along with the known macrocyclic polyester, menisporopsin A, was isolated from the seed fungus Menisporopsis theobromae BCC 4162. The structure of menisposopsin B was addressed primarily by spectroscopic analyses, and the stereochemistry was established by chemical correlation. Menisporopsin B exhibited antimalarial activity with an IC(50) value of 1.0 microg/ml.
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand.
authors.forename: Vasimon
authors.initials: V
authors.lastname: Ruanglek
authors.forename: Supichar
authors.initials: S
authors.lastname: Chokpaiboon
authors.forename: Nakul
authors.initials: N
authors.lastname: Rattanaphan
authors.forename: Siribhorn
authors.initials: S
authors.lastname: Madla
authors.forename: Patchanee
authors.initials: P
authors.lastname: Auncharoen
authors.forename: Taridaporn
authors.initials: T
authors.lastname: Bunyapaiboonsri
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000962:Antimalarials; D018942:Macrolides; D011091:Polyesters; C485925:menisporopsin A; C529096:menisporopsin B