title: Polycyclic framework synthesis of anominine and tubingensin A indole diterpenoids.
abstract: A highly congested decalin embodying an alpha-methylene ketone is synthesized in 11 steps from the Wieland-Miescher ketone and efficiently converted to the polycyclic frameworks of anominine and tubingensin A, which constitutes the first approach to the skeleton of these indole diterpenoids.
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain.
authors.forename: Ben
authors.initials: B
authors.lastname: Bradshaw
authors.forename: Gorka
authors.initials: G
authors.lastname: Etxebarria-Jardí
authors.forename: Josep
authors.initials: J
authors.lastname: Bonjoch
mesh_terms: D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry; D011083:Polycyclic Compounds / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D007211:Indoles; D007659:Ketones; D009281:Naphthalenes; D011083:Polycyclic Compounds; C007229:decalin