[The role of genetic factors in development of atrial fibrillation].
The review is devoted to problems of pathogenesis of atrial fibrillation and role of genetic factors in its development. Significance of genetic factors for origination of atrial fibrillation has been proved by aggregation of the disease in families. This review contains consideration of main candidate genes possibly related to development of the disease and detailed contemplation of value of polymorphisms of potassium and other ion channels. Data on candidate genes common for arterial hypertension and atrial fibrillation which encode components of renin-angiotensin system, NO-synthase, beta-adrenoreceptors are also presented. Probable role of genes encoding components of synthesis and transport of lipids, markers and mediators of inflammation is considered as well.
Gorshkova
E S
ES
Minushkina
L O
LO
Zateĭshchikov
D A
DA
Sidorenko
B A
BA
D001281:Atrial Fibrillation / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics
D005819:Genetic Markers; D015221:Potassium Channels