title: Phytochemical investigation of Tiarella polyphylla.
abstract: Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3beta-hydroxy-20(29)lupen-27-oic acid (9), beta-sitosterol-3-O-beta-D-glucoside (10), stigmasterol-3-O-beta-D-glucoside (11), beta-sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis.
authors.affiliation: College of Pharmacy, Yanbian University, Yanji 133000, PR China.
authors.forename: Guanghai
authors.initials: G
authors.lastname: Shen
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Joongku
authors.initials: J
authors.lastname: Lee
authors.forename: Kyung Seop
authors.initials: KS
authors.lastname: Ahn
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D051056:Complement Inactivating Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003171:Complement Pathway, Classical / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031995:Saxifragaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D051056:Complement Inactivating Agents; D005419:Flavonoids; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes