Adamantane-resistant influenza infection during the 2004-05 season.
Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared. We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005. Resistant and susceptible viruses caused similar symptoms and illness duration. The prevalence of resistance was highest in children.
Rahman
Mahbubur
M
Epidemiology Research Center (ML2), Marshfield Clinic Research Foundation, 1000 N. Oak Avenue, Marshfield, WI 54449, USA.
Bright
Rick A
RA
Kieke
Burney A
BA
Donahue
James G
JG
Greenlee
Robert T
RT
Vandermause
Mary
M
Balish
Amanda
A
Foust
Angela
A
Cox
Nancy J
NJ
Klimov
Alexander I
AI
Shay
David K
DK
Belongia
Edward A
EA
D000218:Adamantane / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004196:Disease Outbreaks; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D009981:Influenza B virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D014922:Wisconsin / Q000453:epidemiology
D000998:Antiviral Agents; D000218:Adamantane