title: Protein targeting to ATP-dependent proteases.
abstract: ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.
authors.affiliation: Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Hogan 2-100 Northwestern University, Evanston, IL, USA.
authors.forename: Tomonao
authors.initials: T
authors.lastname: Inobe
authors.forename: Andreas
authors.initials: A
authors.lastname: Matouschek
mesh_terms: D049069:ATP-Dependent Proteases / Q000737:chemistry* / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport; D013379:Substrate Specificity; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D025801:Ubiquitin; D049069:ATP-Dependent Proteases; D046988:Proteasome Endopeptidase Complex