title: Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants.
abstract: Experiments on Wistar rats showed that subacute poisoning with anticholinesterase toxicants zarin and agent VX (daily subcutaneous injections in 1/7 LD50 for 6 days) led to suppression of cellular and humoral immune reactions and to a decrease in blood concentrations of cytokines (IL-2, IL-4, IFN-gamma) with a reduction of the IFN-gamma/IL-4 and IL-2/IL-4 ratios, which attests to more pronounced decrease in Th1 lymphocyte function in comparison with Th2 cells.
authors.affiliation: Saratov Military Institute of Radiation, Chemical, and Biological Protection. pz@renet.com.ru
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V G
authors.initials: VG
authors.lastname: Germanchuk
authors.forename: V G
authors.initials: VG
authors.lastname: Mandych
authors.forename: A M
authors.initials: AM
authors.lastname: Kadushkin
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D008297:Male; D062025:Organophosphate Poisoning; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012524:Sarin / Q000506:poisoning*; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*
chemical_list: D002800:Cholinesterase Inhibitors; D007371:Interferon-gamma; D007376:Interleukin-2; D015847:Interleukin-4; D009946:Organothiophosphorus Compounds; D012524:Sarin; C009680:VX-agent