title: Patho-epidemiology of cancer corpus uteri in Karachi South '1995-1997'.
abstract: OBJECTIVE
  To provide demographics and pathology of cancer of the uterine corpus in Karachi.
  
  
  METHODS
  Data for 66 incident cases of cancer corpus uteri, ICD-10 category C54-5 registered at the Karachi Cancer Registry, for Karachi South, during a 3 year period, 1st January, 1995 to 31st December 1997 were reviewed.
  
  
  RESULTS
  Cancer uterine corpus (1995-97) was the sixth most common malignancy, following breast, oral cavity, ovary, esophagus and cervix. The age standardized incidence rate (ASR) world and crude incidence rate (CIR) per 100,000 were 6.4 (4.73 to 8.01) and 2.9 (2.18 to 3.57). The mean age was 53.7 years (SD 15.6; range 6-90 years). Fifty eight cases were endometrial carcinoma with ASR world and CIR per 100,000 of 5.77 (4.20 to 7.33) and 2.53 (1.88 to 3.18) respectively. Sarcomas comprised 6% of the cases. Approximately a third of the females (28.8%) were below 50 years of age. The age-specific curves showed a gradual increase from the fourth till the seventh decade, followed by an actual apparent decrease in risk after 70 years. Peak incidence was observed in the 65-69 year age group. Presenting symptoms were post-menopausal bleeding (86.4%) and purulent discharge (4%). Associated pathologies included adenomyosis, adenomatous hyperplasia (12% each) or leiomyoma (8%). Associated clinical conditions were diabetes mellitus and hypertension (4% each). The majority of the cases presented as well differentiated (39.4%), localized (59.1%) lesions.
  
  
  CONCLUSIONS
  The incidence of cancer corpus uteri in Karachi South reflects a moderate risk population, predominantly middle aged with a higher socio-economic status. On the average the malignancy is observed a decade earlier then reported elsewhere. This calls for in-depth investigation of risk factors and identification of underlying etiology.
authors.affiliation: Pathology & Microbiology Department, Agakhan University, Stadium Road, Karachi, Pakistan. bhurgri@cyber.net.pk
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Bhurgri
authors.forename: Kauser
authors.initials: K
authors.lastname: Nazir
authors.forename: Yasmeen
authors.initials: Y
authors.lastname: Shaheen
authors.forename: Ahmed
authors.initials: A
authors.lastname: Usman
authors.forename: Naveen
authors.initials: N
authors.lastname: Faridi
authors.forename: Hadi
authors.initials: H
authors.lastname: Bhurgri
authors.forename: Jawaid
authors.initials: J
authors.lastname: Malik
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Bashir
authors.forename: Asif
authors.initials: A
authors.lastname: Bhurgri
authors.forename: Sheema H
authors.initials: SH
authors.lastname: Hasan
authors.forename: Naila
authors.initials: N
authors.lastname: Kayani
authors.forename: S H M
authors.initials: SH
authors.lastname: Zaidi
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors; D012509:Sarcoma / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D055815:Young Adult