title: A careful disorderliness in the proteome: sites for interaction and targets for future therapies.
abstract: The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein-protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules.
authors.affiliation: EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. russell@embl.de
authors.forename: Robert B
authors.initials: RB
authors.lastname: Russell
authors.forename: Toby J
authors.initials: TJ
authors.lastname: Gibson
mesh_terms: D040901:Proteomics; D013812:Therapeutics