title: Secular trends in the treatment of hyperemesis gravidarum.
abstract: The purpose of this study was to describe the treatment of women with hyperemesis gravidarum (HG). Women with HG pregnancies of at least 27 weeks duration occurring between 1985 and 2004 described their treatment on an HG website from 2003 to 2005. The usage and effectiveness of > 20 treatment options were reported by 765 women for 1193 pregnancies. The women who used intravenous (IV) hydration, serotonin inhibitors, and parenteral nutrition (PN) reported the highest rates of effectiveness, with 84%, 83%, and 79% reporting that these respective treatments may have contributed to decreased nausea/vomiting. The use of conventional treatments increased from 20 to 30% to > 60% between 1985 and 1989 and 2000 and 2004; serotonin inhibitor use increased to 55% after its introduction in the 1990s. Over the past 20 years, multiple treatments have been used for women with HG, with a trend toward treatment with reportedly more effective modalities, such as IV hydration and serotonin inhibitors.
authors.affiliation: University of Southern California, Keck School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, California, USA.
authors.forename: T Murphy
authors.initials: TM
authors.lastname: Goodwin
authors.forename: Borzouyeh
authors.initials: B
authors.lastname: Poursharif
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Korst
authors.forename: Kimber W
authors.initials: KW
authors.lastname: MacGibbon
authors.forename: Roberto
authors.initials: R
authors.lastname: Romero
authors.forename: Marlena S
authors.initials: MS
authors.lastname: Fejzo
mesh_terms: D005260:Female; D006306:Health Surveys; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000628:therapy*; D009862:Online Systems; D011247:Pregnancy; D016896:Treatment Outcome