title: Cancer of the urinary bladder neovagina in a patient with Morris' syndrome.
abstract: BACKGROUND
  Vaginal agenesis is a rare condition, therefore the incidence of a malignant transformation in the neovagina is extremely low.
  
  
  METHODS
  We report on a 42-year-old patient with Morris' syndrome and urinary bladder neovagina with a history of prolonged infections of the urinary bladder and intertrigo of the perineal region. The biopsy revealed a squamous cell carcinoma arising from the neovagina. The patient underwent combined radio- and chemotherapy and was disqualified from surgical treatment because of the advanced stage of the disease.
  
  
  CONCLUSIONS
  Because of the high risk of malignant transformations regular follow-ups are necessary in patients with neovagina creation, including gynecological examination, cytological screening, and biopsy if necessary. In addition, urinary bladder does not seem to be a good material for a functional vagina.
authors.affiliation: 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland. mwielgos@amwaw.edu.pl
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Wielgos
authors.forename: Iwona
authors.initials: I
authors.lastname: Szymusik
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Banaszek
authors.forename: Barbara
authors.initials: B
authors.lastname: Suchonska
authors.forename: Pawel
authors.initials: P
authors.lastname: Kaminski
authors.forename: Halina
authors.initials: H
authors.lastname: Gadomska
authors.forename: Leszek
authors.initials: L
authors.lastname: Bablok
mesh_terms: D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000473:pathology / Q000601:surgery*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010388:Pelvis / Q000473:pathology; D011183:Postoperative Complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D011867:Radioisotope Teletherapy; D019651:Plastic Surgery Procedures; D013524:Surgical Flaps / Q000473:pathology*; D013577:Syndrome; D001743:Urinary Bladder / Q000473:pathology*; D014621:Vagina / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery*; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy
chemical_list: D002945:Cisplatin