title: [vrk1 gene mutation test in two Chinese pedigrees of the first and second branchial arch syndrome].
abstract: OBJECTIVE
  To explore the role of vrk1 gene in two Chinese pedigrees of the first and second branchial arch syndrome.
  
  
  METHODS
  Sixty members in 2 Chinese pedigrees were recruited. The exon 2 -13 were analyzed by polymerase chain reaction and direct sequencing.
  
  
  RESULTS
  We found a new SNP in proband of Shandong pedigree.
  
  
  CONCLUSIONS
  vrk1 gene mutation can be excluded in 2 Chinese pedigrees of the first and second branchial arch syndrome.
authors.affiliation: The Center of External Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing, 100041, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Pan
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Haiyue
authors.initials: H
authors.lastname: Jiang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cai
authors.forename: Dashan
authors.initials: D
authors.lastname: Yu
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhuang
mesh_terms: D044466:Asian People / Q000235:genetics; D001934:Branchial Region; D005091:Exons; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008265:Macrostomia / Q000235:genetics; D008297:Male; D009154:Mutation; D010375:Pedigree; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D013577:Syndrome
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; C109890:VRK1 protein, human