title: Human health risk assessment related to cyanotoxins exposure.
abstract: This review focuses on the risk assessment associated with human exposure to cyanotoxins, secondary metabolites of an ubiquitous group of photosynthetic procariota. Cyanobacteria occur especially in eutrophic inland and coastal surface waters, where under favorable conditions they attain high densities and may form blooms and scums. Cyanotoxins can be grouped according to their biological effects into hepatotoxins, neurotoxins, cytotoxins, and toxins with irritating potential, also acting on the gastrointestinal system. The chemical and toxicological properties of the main cyanotoxins, relevant for the evaluation of possible risks for human health, are presented. Humans may be exposed to cyanotoxins via several routes, with the oral one being by far the most important, occurring by ingesting contaminated drinking water, food, some dietary supplements, or water during recreational activities. Acute and short-term toxic effects have been associated in humans with exposure to high levels of cyanotoxins in drinking and bathing waters. However, the chronic exposure to low cyanotoxin levels remains a critical issue. This article identifies the actual risky exposure scenarios, provides toxicologically derived reference values, and discusses open issues and research needs.
authors.affiliation: Environment and Primary Prevention Department, Istituto Superiore di Sanità, Rome, Italy. enzo.funari@iss.it
authors.forename: Enzo
authors.initials: E
authors.lastname: Funari
authors.forename: Emanuela
authors.initials: E
authors.lastname: Testai
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000009:adverse effects* / Q000737:chemistry; D000458:Cyanobacteria / Q000472:pathogenicity / Q000502:physiology*; D000087522:Cyanobacteria Toxins; D004781:Environmental Exposure / Q000009:adverse effects*; D004782:Environmental Health; D005506:Food Contamination; D006801:Humans; D008387:Marine Toxins / Q000009:adverse effects* / Q000737:chemistry; D052998:Microcystins / Q000009:adverse effects* / Q000737:chemistry; D009498:Neurotoxins / Q000009:adverse effects* / Q000737:chemistry; D011998:Recreation; D012016:Reference Values; D018570:Risk Assessment; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000737:chemistry; D014881:Water Supply / Q000032:analysis
chemical_list: D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D008387:Marine Toxins; D052998:Microcystins; D009498:Neurotoxins; D014874:Water Pollutants, Chemical