Glycan arrays: biological and medical applications.
Carbohydrates and their conjugates are involved in various biological events, including viral and bacterial infection, the immune response, differentiation and development, and the progression of tumor cell metastasis. Glycan arrays are a new technology that has enabled the high-sensitivity and rapid analysis carbohydrate-protein interaction and contribute to significant advances in glycomics. Glycan arrays use a minute amount of materials and can be used for high-throughput profiling and quantitative analysis and provide information for the development of carbohydrate-based vaccines and new drug discovery.
Liang
Pi-Hui
PH
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Wu
Chung-Yi
CY
Greenberg
William A
WA
Wong
Chi-Huey
CH
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006801:Humans; D037102:Lectins / Q000378:metabolism; D046228:Microarray Analysis; D011134:Polysaccharides / Q000276:immunology / Q000378:metabolism*; D014780:Viruses / Q000378:metabolism
D037102:Lectins; D011134:Polysaccharides