title: [Implementation and electrophysiological validation of combined fMRI and DTI imaging for visualization of cortico-subcortical connectivity].
abstract: The combined application of functional magnetic resonance imaging and diffusion tensor based tractography is a reliable technique to localize cortico-subcortical functional systems of the brain. This technical feature will be particularly important for image-guided neurosurgery as well as for intaroperative imaging in future. Due to methodological limitations and external factors (intraoperative brain shift, interstitial brain edema) these MR imaging modalities need to be supplemented by intraoperative electrophysiological mapping techniques. For this purpose, navigated bipolar stimulation is especially appropriate to validate imaging findings and to preserve the functional integrity of cortico-subcortical systems.
authors.affiliation: Klinik für Neurochirurgie, Universitätsklinikum Tübingen. alireza.gharabaghi@uni-tuebingen.de
authors.forename: Alireza
authors.initials: A
authors.lastname: Gharabaghi
authors.forename: Ralf
authors.initials: R
authors.lastname: Saur
authors.forename: Frank
authors.initials: F
authors.lastname: Kunath
authors.forename: Stefan
authors.initials: S
authors.lastname: Heckl
authors.forename: Michael
authors.initials: M
authors.lastname: Erb
authors.forename: Thomas
authors.initials: T
authors.lastname: Nägele
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grodd
authors.forename: Marcos
authors.initials: M
authors.lastname: Tatagiba
mesh_terms: D001921:Brain / Q000502:physiology*; D001927:Brain Diseases / Q000473:pathology*; D001929:Brain Edema / Q000473:pathology*; D002540:Cerebral Cortex / Q000502:physiology*; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D004558:Electric Stimulation; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging