Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata.
Three lipopeptides, ciliatamides A-C ( 1- 3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A ( 1) and B ( 2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.
Nakao
Yoichi
Y
The University of Tokyo, Tokyo, Japan. ayocha@waseda.jp
Kawatsu
Shizuka
S
Okamoto
Chikane
C
Okamoto
Masaaki
M
Matsumoto
Yoshitsugu
Y
Matsunaga
Shigeki
S
van Soest
Rob W M
RW
Fusetani
Nobuhiro
N
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009792:Oceans and Seas; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D055666:Lipopeptides; D008074:Lipoproteins; D009842:Oligopeptides; C529041:ciliatamide A; C529042:ciliatamide B; C529043:ciliatamide C