Improvement of solubility of C70 by complexation with cyclomaltononaose (delta-cyclodextrin).
We investigated the solubilizing effects of cyclomaltononaose (delta-CD), a cyclic oligosaccharide composed of nine alpha-1,4-linked D-glucose units, on C70 by using the ball-milling method based on a solid-solid mechanochemical reaction. The complex between C70 and delta-CD was characterized by UV-VIS spectrometry and fast atom bombardment mass spectrometry (FAB-MS). Coloration of the C70/delta-CD system was red-brown in aqueous solution, and the UV-VIS spectrum was in agreement with that of C70 in hexane solution. The FAB-MS spectrum of the C70/delta-CD system showed a negative ion peak corresponding to the molecular weight of a complex between two delta-CD and one C70. These findings suggest that the solubilization of C70 in water was due to complex formation of C70 with delta-CD, and the stoichiometric ratio of this complex was 1: 2 (C70: delta-CD).
Furuishi
T
T
Research Unit of Pharmaceutics, College of Pharmacy, Nihon University, Chiba, Japan.
Fukami
T
T
Nagase
H
H
Suzuki
T
T
Endo
T
T
Ueda
H
H
Tomono
K
K
D037741:Fullerenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D012996:Solutions; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction; D047408:gamma-Cyclodextrins / Q000737:chemistry*
D037741:Fullerenes; D012996:Solutions; D047408:gamma-Cyclodextrins; C069836:fullerene C70; C023792:gamma-cyclodextrin