title: [Improved diagnostics of cerebral gliomas using FET PET].
abstract: Positron emission tomography (PET) using radiolabeled amino acids has shown great potential for more accurate diagnostics of cerebral gliomas. O-(2-[18F]Fluoroethyl)-L-tyrosine (FET) is a new tracer for PET which can be produced with high efficiency and distributed on a wide clinical scale in Germany. In a biopsy-controlled study, a significant improvement of the detection of true tumor extent of cerebral gliomas could be demonstrated by the combined use of FET PET and MRT in comparison with MRT alone. Advantages of FET PET are an improved guidance of biopsies, an improved planning of surgery and radiation therapy, and the differentiation of tumor recurrence from unspecific post-therapeutic tissue changes. Furthermore, FET PET appears to be particularly valuable in the prognosis of low-grade gliomas.
authors.affiliation: Institut für Neurowissenschaften und Biophysik, Abteilung für Medizin, Forschungszentrum Jülich. k.j.langen@fz-juelich.de
authors.forename: Karl-Josef
authors.initials: KJ
authors.lastname: Langen
authors.forename: Frank W
authors.initials: FW
authors.lastname: Floeth
authors.forename: Gabriele
authors.initials: G
authors.lastname: Stoffels
authors.forename: Kurt
authors.initials: K
authors.lastname: Hamacher
authors.forename: Heinz H
authors.initials: HH
authors.lastname: Coenen
authors.forename: Dirk
authors.initials: D
authors.lastname: Pauleit
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005462:Fluorine Radioisotopes; D005858:Germany; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D012955:Societies, Medical; D014443:Tyrosine / Q000031:analogs & derivatives*
chemical_list: D005462:Fluorine Radioisotopes; C105990:2-fluoro-alpha-methyltyrosine; D014443:Tyrosine