title: Elevation of high-mobility group box 1 concentration in asphyxiated neonates.
abstract: BACKGROUND
  In asphyxiated neonates, abnormal proinflammatory cytokine/chemokine production may be induced. High-mobility group box 1 (HMGB-1) protein is a new type of proinflammatory cytokine that induces abnormal inflammatory responses involving proinflammatory cytokine production. However, the physiological significance of HMGB-1 in asphyxia is poorly understood.
  
  
  OBJECTIVE
  We aimed to evaluate whether serum HMGB-1 levels were changed in asphyxia by measuring the serum concentration of HMGB-1 in both asphyxiated and normally delivered neonates at birth.
  
  
  METHODS
  Using enzyme-linked immunosorbent assay, we measured the concentration of HMGB-1 in sera obtained from 53 asphyxiated neonates and 32 normally delivered neonates immediately after birth.
  
  
  RESULTS
  The serum concentrations of HMGB-1 in asphyxiated neonates were significantly higher than those in normally delivered neonates without asphyxia (p = 0.033).
  
  
  CONCLUSIONS
  We suggest that the elevation of HMGB-1 might be associated with abnormal inflammatory responses involving the excessive production of proinflammatory cytokines in neonates with asphyxia.
authors.affiliation: Tokyo Metropolitan Hachioji Children's Hospital, Tokyo, Japan. okazaki@chp.hachioji.tokyo.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okazaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kondo
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kato
authors.forename: Ryota
authors.initials: R
authors.lastname: Kakinuma
authors.forename: Akira
authors.initials: A
authors.lastname: Nishida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Noda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D001724:Birth Weight; D004797:Enzyme-Linked Immunosorbent Assay; D005865:Gestational Age; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn
chemical_list: D024243:HMGB1 Protein