title: Optimizing management of metabolic syndrome to reduce risk: focus on life-style.
abstract: The prevalence of metabolic syndrome (MS) is increasing all over the world and its incidence is expected to rise in the next years. Although genetic predisposition appears to play an important role in the regulation of metabolic parameters and in particular of body weight, the rapid increase in the prevalence of obesity and MS suggests that ecological factors (social, economic, cultural and physical environment) are promoting those conditions in susceptible individuals. People with MS are at increased risk of type 2 diabetes and cardiovascular disease and therefore they represent a priority target for preventive strategies. Life-style modifications based on healthy diet and increased physical activity are an effective preventing and therapeutic approach. Unfortunately, implementation of life-style modification and maintenance of effects is a difficult task both at personal and social level, thus drug therapy can be taken into account.
authors.affiliation: Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Pisa, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bianchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Penno
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Daniele
authors.forename: Luca
authors.initials: L
authors.lastname: Benzi
authors.forename: Stefano
authors.initials: S
authors.lastname: Del Prato
authors.forename: Roberto
authors.initials: R
authors.lastname: Miccoli
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D015444:Exercise; D005247:Feeding Behavior; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D009043:Motor Activity; D009752:Nutritional Status; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012907:Smoking / Q000009:adverse effects