Zeatin supplement improves scopolamine-induced memory impairment in mice.
In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.
Kim
Mi Jeong
MJ
Brain Korea 21 Project for Medicine, Yonsei University, Seoul 120-752, South Korea.
Choi
Soo Jung
SJ
Lim
Seung-Taik
ST
Kim
Hye Kyung
HK
Kim
Young Jun
YJ
Yoon
Ho-Geun
HG
Shin
Dong-Hoon
DH
D000818:Animals; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D008569:Memory Disorders / Q000517:prevention & control*; D051379:Mice; D012601:Scopolamine / Q000009:adverse effects*; D015026:Zeatin / Q000008:administration & dosage / Q000494:pharmacology*
D018680:Cholinergic Antagonists; D015026:Zeatin; D012601:Scopolamine