title: Clinical significance of topical instillation technique in Japanese glaucoma patients.
abstract: The clinical significance of a proper eye drop application technique was evaluated in Japanese glaucoma patients. Patients diagnosed with primary open-angle glaucoma having intraocular pressure (IOP) greater than 21 mmHg were treated with eye drops at home. In some patients, however, the topical treatment was ineffective. They returned to the hospital to receive surgical treatment. On admission, 56% of these patients had IOP greater than 21 mmHg. Patient instillation technique was evaluated based on the proximity of the eyedropper tip to the eyes, application position, eyelid closure, treatment (removal) of excess fluid, and nasolacrimal occlusion. In addition, pharmacists interviewed patients to determine the level of understanding of glaucoma, knowledge of prescribed drugs, home application technique, and sensation after application. Multivariate analysis revealed that the key factors influencing the control of IOP to less than 21 mmHg with topical medication were: application of drops in the center of the eye and removal of excessive fluid, in addition to gender and age. Proper topical application at home was dependent on the patient's understanding of the disease, knowledge of prescribed drugs, patient education on the use of drugs, the competence of the instructor, and knowledge of correct application technique. This study indicates that easily comprehensible patient education on the use of eye drops, the nature of glaucoma and the proper use of prescribed drugs is vital to improving the clinical efficacy of topical ophthalmic medication of glaucoma in adult patients.
authors.affiliation: Department of Pharmacy Services, Hiroshima University Hospital, Japan. ike@hiroshima-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: A
authors.initials: A
authors.lastname: Sugimoto
authors.forename: A
authors.initials: A
authors.lastname: Sawa
authors.forename: B L
authors.initials: BL
authors.lastname: Crabtree
authors.forename: H J
authors.initials: HJ
authors.lastname: Byrd
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: H K
authors.initials: HK
authors.lastname: Mishima
authors.forename: K
authors.initials: K
authors.lastname: Kihira
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D010595:Pharmacists
chemical_list: D009883:Ophthalmic Solutions