title: Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: a case report.
abstract: Mantle cell lymphoma (MCL) commonly invades the gastrointestinal (GI) tract. However, primary GI MCL is rare. We experienced a case of synchronous early gastric cancer (EGC) with primary gastric MCL found as a single early lesion rather than as multiple lymphomatous polyposis. An EGC was found in the cardia of a 64-year-old male on a routine GI endoscopic examination. A specimen obtained by total gastrectomy revealed another slightly elevated lesion in the pylorus. Microscopically, monotonous small- to medium-sized atypical lymphocytes with angulated nuclei formed a mass beneath the gastric mucosa. On immunohistochemical staining, the tumor cells revealed strong positivity for cyclin D1, positivity for both CD20 and bcl-2, and weak positivity for CD5, suggesting MCL. Clinically, there was no lymphoma in any other part of the body. This is the first case of an EGC accompanying a primary gastric MCL. Further investigation of a relationship between MCL and EGC and of factors that may affect GI involvement of MCL is necessary.
authors.affiliation: Department of Pathology, Yonsei University Wonju College of Medicine, #162 Ilsan-dong, Wonju, Gangwon-do, South Korea.
authors.forename: Yosep
authors.initials: Y
authors.lastname: Chong
authors.forename: John Junghun
authors.initials: JJ
authors.lastname: Shin
authors.forename: Mee-Yon
authors.initials: MY
authors.lastname: Cho
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.forename: Ho Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Kwang Hwa
authors.initials: KH
authors.lastname: Park
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor