title: [All-trans retinoic acid syndrome [corrected] and renal cortical necrosis].
abstract: We described a patient with acute promyelocytic leukemia (APL) who developed all-trans retinoic acid syndrome (ATRAS). ATRAS presents in patients with APL treated with all-trans retinoic acid (ATRA). It has an incidence from 5-27% with mortality of 29%. ATRAS clinical manifestations are fever, hypotension, respiratory, renal and hepatic insufficiency, lung infiltrates, pleural and pericardic effusion, and generalized edema. It is secondary to ATRA effect on promyelocyte differentiation, which causes systemic inflammatory response syndrome, endothelium damage with increase in capillary permeability, microcirculation obstruction, and tissue infiltration. Treatment is based on ATRA suspension, steroids and support measures.
authors.affiliation: Servicio de Nefrología, Hospital Universitario Central de Asturias, Oviedo. aranchasastre@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Sastre López
authors.forename: E
authors.initials: E
authors.lastname: Gago González
authors.forename: M
authors.initials: M
authors.lastname: Baños Gallardo
authors.forename: E
authors.initials: E
authors.lastname: Gómez-Huertas
authors.forename: F
authors.initials: F
authors.lastname: Ortega Suárez
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007673:Kidney Cortex Necrosis / Q000139:chemically induced*; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D013577:Syndrome; D014212:Tretinoin / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin