The application of FAST-NMR for the identification of novel drug discovery targets.
The continued success of genome sequencing projects has resulted in a wealth of information, but 40-50% of identified genes correspond to hypothetical proteins or proteins of unknown function. The functional annotation screening technology by NMR (FAST-NMR) screen was developed to assign a biological function for these unannotated proteins with a structure solved by the protein structure initiative. FAST-NMR is based on the premise that a biological function can be described by a similarity in binding sites and ligand interactions with proteins of known function. The resulting co-structure and functional assignment may provide a starting point for a drug discovery effort.
Powers
Robert
R
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68522, USA. rpowers3@unl.edu
Mercier
Kelly A
KA
Copeland
Jennifer C
JC
D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*