title: C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.
abstract: We investigated the association between the MDR1 C3435T polymorphism and P-glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with AML, excluding the M3 subtype. The CC, CT and TT genotype frequencies of the C3435T polymorphism among patients were 71, 93 and 36, respectively. The C3435T polymorphism genotypes did not have influence on the P-glycoprotein function of leukemic blasts. Complete remission rates and overall, relapse-free and event-free survival rates were not significantly different among the C3435T polymorphism genotypes. In conclusion, the MDR1 C3435T polymorphism does not appear to have significant clinical implications in AML.
authors.affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-2dong, Songpa-ku, Seoul, Republic of Korea.
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Hur
authors.forename: Je-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Michael Jinpyo
authors.initials: MJ
authors.lastname: Lee
authors.forename: Seong-Jun
authors.initials: SJ
authors.lastname: Choi
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Mun Jung
authors.initials: MJ
authors.lastname: Kang
authors.forename: Miee
authors.initials: M
authors.lastname: Seol
authors.forename: Yae Eun
authors.initials: YE
authors.lastname: Jang
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ip-Sol
authors.initials: IS
authors.lastname: Kang
authors.forename: Soo-Kyung
authors.initials: SK
authors.lastname: Shim
authors.forename: Seong-Gil
authors.initials: SG
authors.lastname: Ryu
authors.forename: Young-Ah
authors.initials: YA
authors.lastname: Kang
authors.forename: Young-Shin
authors.initials: YS
authors.lastname: Lee
authors.forename: Chan-Jeoung
authors.initials: CJ
authors.lastname: Park
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Kyoo-Hyung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D005260:Female; D019450:Genes, MDR; D005838:Genotype; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1