Molecular epidemiology of human immunodeficiency virus type 1 and hepatitis C virus in former blood donors in central China.
The prevalence of hepatitis C virus (HCV) among human immunodeficiency virus (HIV-1)-positive former blood donors (FBDs) in Hubei province, central China, and the subtypes of these two viruses are identified. HIV-1-positive specimens were collected from FBDs, transfusion recipients, and their sexual partners in Hubei province, central China. The prevalence of HCV in HIV-1-positive FBDs was 78.6%. The dominant circulating HIV-1 subtype of FBDs was subtype B' (Thai-B); one belonged to U.S.-European subtype B. HCV genotypes 2a (78.6%) and 1b (21.4%) were detected. No recombinant form of HIV-1 was identified. Non-B' subtypes occurring among FBDs indicate the complexity of the HIV-1 prevalence in central China, where HIV is beginning to spread into the general population.
Liu
Pingping
P
The State Key Laboratory of Virology, Wuhan Institution of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Xiang
Kunlun
K
Tang
Heng
H
Zhang
Wei
W
Wang
Xiaoqiong
X
Tong
Xiao
X
Takebe
Yutaka
Y
Yang
Rongge
R
D001782:Blood Donors; D002681:China / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D015995:Prevalence; D017422:Sequence Analysis, DNA