title: Potent inhibitors of the hedgehog signaling pathway.
abstract: A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
authors.affiliation: Evotec, Oxfordshire, UK. shirley.brunton@evotec.com
authors.forename: Shirley A
authors.initials: SA
authors.lastname: Brunton
authors.forename: John H A
authors.initials: JH
authors.lastname: Stibbard
authors.forename: Lee L
authors.initials: LL
authors.lastname: Rubin
authors.forename: Lawrence I
authors.initials: LI
authors.lastname: Kruse
authors.forename: Oivin M
authors.initials: OM
authors.lastname: Guicherit
authors.forename: Edward A
authors.initials: EA
authors.lastname: Boyd
authors.forename: Steven
authors.initials: S
authors.lastname: Price
mesh_terms: D000818:Animals; D002460:Cell Line; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D051379:Mice; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D053823:Hedgehog Proteins; D052999:Quinazolinones