title: Stem cell transplantation in advanced cutaneous T-cell lymphoma.
abstract: Cutaneous T-cell lymphomas are a type of indolent non-Hodgkin's lymphoma where patients with limited skin disease can be successfully treated with a variety of skin-directed, systemic, and immunomodulating therapies, whereas durable remissions are difficult to achieve in patients with tumor, erythrodermic, or systemic disease. We describe a patient with cutaneous T-cell lymphoma and malignant cells constituting 99% of her peripheral blood lymphocytes who had a sustained complete response after an HLA-matched sibling allogeneic stem cell transplantation. We also review the current literature regarding both autologous and allogeneic stem cell transplantations for advanced stages of cutaneous T-cell lymphoma, discuss the importance of the graft-versus-tumor immunomodulatory effect in successful transplantations, and suggest that allogeneic stem cell transplantation deserves further consideration and study as a potential treatment for selected patients who are younger and at high risk.
authors.affiliation: Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Camille E
authors.initials: CE
authors.lastname: Introcaso
authors.forename: Brian
authors.initials: B
authors.lastname: Leber
authors.forename: Kathleen
authors.initials: K
authors.lastname: Greene
authors.forename: Ravi
authors.initials: R
authors.lastname: Ubriani
authors.forename: Alain H
authors.initials: AH
authors.lastname: Rook
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Kim
mesh_terms: D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000601:surgery*; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000601:surgery*; D033581:Stem Cell Transplantation