title: The ischemic preconditioning and postconditioning effect on the intestinal mucosa of rats undergoing mesenteric ischemia/reperfusion procedure.
abstract: OBJECTIVE
  To evaluate the effect of the ischemic preconditioning and the ischemic postconditioning over the tissue injury in the intestinal mucosa of rats undergoing the procedure of mesenteric ischemia and reperfusion.
  
  
  METHODS
  Thirty Wistar rats were studied, divided in three groups: group A, undergoing mesenteric ischemia (30 minutes) and reperfusion (60 minutes); group B, mesenteric ischemia and reperfusion preceded by ischemic preconditioning; group C, mesenteric ischemia and reperfusion and, before the beginning of reperfusion, the ischemic postconditioning was performed. At the end, a segment of the small intestine was dissected for histological analysis. The results were evaluated using the CHIU et al.6 classification followed by the statistic treatment.
  
  
  RESULTS
  The mean values of the tissue injury levels were: group A, 3.5; group B, 1.2; and group C, 1. The difference between the result of group A with the results of groups B and C was considered statistically significant (p < 0,05).
  
  
  CONCLUSIONS
  The ischemic preconditioning and postconditioning are able to minimize the tissue injury in the intestines of rats that underwent the procedure of mesenteric ischemia and reperfusion.
authors.affiliation: Surgery Department, UFMS, Campo Grande, Mato Grosso do Sul, Brazil. chmarques@terra.com.br
authors.forename: Carlos Henrique Marques Dos
authors.initials: CH
authors.lastname: Santos
authors.forename: Otoni Moreira
authors.initials: OM
authors.lastname: Gomes
authors.forename: José Carlos Dorsa Vieira
authors.initials: JC
authors.lastname: Pontes
authors.forename: Luciana Nakao Odashiro
authors.initials: LN
authors.lastname: Miiji
authors.forename: Marco Aurélio Feltrin
authors.initials: MA
authors.lastname: Bispo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000473:pathology; D007421:Intestine, Small / Q000098:blood supply* / Q000473:pathology; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D018709:Statistics, Nonparametric