title: Correlation between parameters describing tumour motion and its location in the lungs.
abstract: Characterizing respiratory-induced tumour motion is an important step in the effective image-guided radiation treatment of moving tumours, especially for tumours in the lung and lower abdomen. This study characterized tumour motion based on a piecewise linear model representing tumour motion at defined stages of the breathing cycle. Lung tumour locations were categorized based on broncho-pulmonary segments. Association rules between tumour motion characteristics and their locations in the lung were discovered and parameterized through statistical analysis. Results show there is a correlation between tumour motion characteristics and tumour location in the lungs. Generally, tumours with small motion (amplitude < 10 mm) are observed most frequently in the apex region of lung or when attached to a fixed structure, such as the chest wall or aorta. Tumours with relatively large motion (amplitude > 20 mm) are located close to the diaphragm or mid-level periphery of the lungs close to the chest wall.
authors.affiliation: Purdue School of Engineering and Technology, IUPUI, Indianapolis, IN, USA. hw9@iupui.edu
authors.forename: Huanmei
authors.initials: H
authors.lastname: Wu
authors.forename: George
authors.initials: G
authors.lastname: Sandison
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Qingya
authors.initials: Q
authors.lastname: Zhao
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
authors.forename: Steve
authors.initials: S
authors.lastname: Jiang
mesh_terms: D006801:Humans; D016014:Linear Models; D008175:Lung Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D008954:Models, Biological; D009068:Movement; D011880:Radiotherapy Planning, Computer-Assisted; D015656:Respiratory Mechanics; D012189:Retrospective Studies