title: Standardized T2* map of a normal human heart to correct T2* segmental artefacts; myocardial iron overload and fibrosis in thalassemia intermedia versus thalassemia major patients and electrocardiogram changes in thalassemia major patients.
abstract: Studies of the standardized, 3D, 16-segments map of the circumferential distribution of T2* values, of cardiovascular magnetic resonance (CMR) in thalassemia major (TM) and thalassemia intermedia (TI) patients and of electrocardiogram (ECG) changes associated with TM, have been carried out. Similarly, the segment-dependent correction map of the T2* values and the artifactual variations in normal subjects and the T2* correction map to correct segmental measurements in patients with different levels of myocardial iron burden have been evaluated. Cardiovascular magnetic resonance can be a suitable guide to cardiac management in TI, as well as in TM; TI patients show lower myocardial iron burden and more pronounced high cardiac output findings than TM patients. Moreover, it is proposed that, due to its good positive predictive value (PPV) and low cost, ECG can be a suitable guide to orient towards CMR examination in TM cases.
authors.affiliation: Magnetic Resonance Imaging Laboratory, Institute of Clinical Physiology, CNR, Pisa, Italy. miot@ifc.cnr.it
authors.forename: Anna
authors.initials: A
authors.lastname: Ramazzotti
authors.forename: Alessia
authors.initials: A
authors.lastname: Pepe
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Positano
authors.forename: Barbara
authors.initials: B
authors.lastname: Scattini
authors.forename: Maria F
authors.initials: MF
authors.lastname: Santarelli
authors.forename: Luigi
authors.initials: L
authors.lastname: Landini
authors.forename: Daniele
authors.initials: D
authors.lastname: De Marchi
authors.forename: Petra
authors.initials: P
authors.lastname: Keilberg
authors.forename: Giorgio
authors.initials: G
authors.lastname: Derchi
authors.forename: Francesco
authors.initials: F
authors.lastname: Formisano
authors.forename: Marcello
authors.initials: M
authors.lastname: Pili
authors.forename: Maria E
authors.initials: ME
authors.lastname: Lai
authors.forename: Gianluca
authors.initials: G
authors.lastname: Forni
authors.forename: Aldo
authors.initials: A
authors.lastname: Filosa
authors.forename: Luciano
authors.initials: L
authors.lastname: Prossomariti
authors.forename: Marcello
authors.initials: M
authors.lastname: Capra
authors.forename: Lorella
authors.initials: L
authors.lastname: Pitrolo
authors.forename: Caterina
authors.initials: C
authors.lastname: Borgna-Pignatti
authors.forename: Paolo
authors.initials: P
authors.lastname: Cianciulli
authors.forename: Aurelio
authors.initials: A
authors.lastname: Maggio
authors.forename: Massimo
authors.initials: M
authors.lastname: Lombardi
mesh_terms: D000328:Adult; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D005355:Fibrosis; D006801:Humans; D019190:Iron Overload / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D013789:Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology