title: Excimer laser in acute myocardial infarction: single centre experience on 66 patients.
abstract: BACKGROUND
  Pulsed-wave ultraviolet excimer laser light at 308 nm can vaporise thrombus, suppress platelet aggregation, and, unlike other thrombectomy devices, ablates the underlying plaque.
  
  
  OBJECTIVE
  To evaluate both safety and efficacy of laser ablation in patients presenting with Acute Myocardial Infarction (AMI) complicated by persistent thrombotic occlusion.
  
  
  METHODS
  From May 2003 to October 2006, we enrolled 66 AMI patients (age 59+/-11 years; 57 men) presenting complete thrombotic occlusion of the infarct related vessel. All patients were treated with laser. Primary acute angiographic end-points was corrected TIMI frame count. Secondary echocardiographic end-point was left ventricular remodeling defined as an increase in end-diastolic volume >/=20% 6 months after infarction. Tertiary clinical endpoint was event-free survival at 6 months follow-up.
  
  
  RESULTS
  There were no intra-procedural death or coronary perforation. One primary angiographic failure was observed during lasing. Major dissection occurred in 1 (1.5%) and distal embolization in 4 patients (6%). Corrected TIMI frame count was 100 at baseline, 29+/-0.6 after lasing and 22+/-3 after stenting. At 6-months follow-up, left ventricular remodeling occurred in 8% patients. Event-free survival was 95% at 6-months follow-up.
  
  
  CONCLUSIONS
  Laser angioplasty is feasible, safe and effective for the challenging treatment of patients with AMI and thrombus-laden lesions. The acute effects on coronary epicardial and myocardial reperfusion are excellent.
authors.affiliation: CNR, Institute of Clinical Physiology, Pisa, Italy; Clinica Cardiologica "Montevergine", Mercogliano, Italy. scientific1@virgilio.it
authors.forename: V
authors.initials: V
authors.lastname: Ambrosini
authors.forename: A
authors.initials: A
authors.lastname: Cioppa
authors.forename: L
authors.initials: L
authors.lastname: Salemme
authors.forename: T
authors.initials: T
authors.lastname: Tesorio
authors.forename: G
authors.initials: G
authors.lastname: Sorropago
authors.forename: G
authors.initials: G
authors.lastname: Popusoi
authors.forename: E
authors.initials: E
authors.lastname: Stabile
authors.forename: A
authors.initials: A
authors.lastname: Medolla
authors.forename: F
authors.initials: F
authors.lastname: Cangella
authors.forename: M
authors.initials: M
authors.lastname: Agrusta
authors.forename: E
authors.initials: E
authors.lastname: Picano
authors.forename: P
authors.initials: P
authors.lastname: Rubino
mesh_terms: D017222:Angioplasty, Balloon, Laser-Assisted; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D004452:Echocardiography; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome