title: A comprehensive approach toward novel serum biomarkers for benign prostatic hyperplasia: the MPSA Consortium.
abstract: OBJECTIVE
  Clinical benign prostatic hyperplasia is primarily diagnosed based on a diverse array of progressive lower urinary tract symptoms and is likely distinct from histological benign prostatic hyperplasia, which is detected by the presence of nonmalignant proliferation of prostate cells but may or may not be associated with symptoms. Pharmacological management of lower urinary tract symptoms has emerged as an effective initial treatment for clinical benign prostatic hyperplasia due to the introduction of new drug therapies shown to be effective in recent large clinical trials. Despite advances in symptom management and research into disease pathology, diagnostic strategies for the prediction of benign prostatic hyperplasia progression and response to drug modalities are lacking, and questions remain as to the molecular differences underlying clinical (symptomatic) vs histological (nonsymptomatic) benign prostatic hyperplasia.
  
  
  METHODS
  As part of the Medical Therapy of Prostatic Symptoms (MTOPS) clinical trial, which demonstrated the effectiveness of combination drug therapy in slowing benign prostatic hyperplasia progression, an archive of biological specimens linked to clinical data was collected for future profiling of disease pathology and changes associated with response to drug therapy. The MTOPS Prostatic Samples Analysis (MPSA) Consortium was established to identify and validate molecular markers that may better define benign prostatic hyperplasia related pathologies, identify risk of progression of lower urinary tract symptoms, and predict response to drug therapy using the MTOPS archive. The cooperating MPSA Biomarker Discovery Sites and Pathology Coordinating Center use diverse methodologies and scientific approaches as well as unique expertise to address the goals of the Consortium.
  
  
  RESULTS
  To date the MPSA has identified a number of promising biomarkers as well as other molecular and cellular changes associated with benign prostatic hyperplasia.
  
  
  CONCLUSIONS
  These findings and ongoing Consortium discovery efforts have the potential to provide a greater understanding of the defects underlying disease pathology, and may lead to the development of early and more effective pharmacological treatment strategies for benign prostatic hyperplasia.
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Mullins
authors.forename: M Scott
authors.initials: MS
authors.lastname: Lucia
authors.forename: Simon W
authors.initials: SW
authors.lastname: Hayward
authors.forename: Jeannette Y
authors.initials: JY
authors.lastname: Lee
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Levitt
authors.forename: Victor K
authors.initials: VK
authors.lastname: Lin
authors.forename: Brian C-S
authors.initials: BC
authors.lastname: Liu
authors.forename: Arul M
authors.initials: AM
authors.lastname: Chinnaiyan
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rubin
authors.forename: Kevin
authors.initials: K
authors.lastname: Slawin
authors.forename: Robert A
authors.initials: RA
authors.lastname: Star
authors.forename: Robert H
authors.initials: RH
authors.lastname: Getzenberg
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics
chemical_list: D015415:Biomarkers