Preparation of micro-fabricated biodegradable polymeric structures using NCDS.
PLGA scaffolds were prepared using a nano-composite deposition system (NCDS). 5-Fluorouracil (5-FU) was used as a model drug. Hydroxyapatite (HA) was included in the scaffolds to improve the mechanical properties of the scaffolds and modulate the release of 5-FU from the scaffolds. 5-FU and HA were dispersed well in the prepared scaffolds when evaluated with SEM, FT-IR, XRPD and DSC. The release of 5-FU from the prepared scaffolds consisting of different compositions was determined using 40 mL PBS as the medium. The release profiles of 5-FU from PLGA scaffolds followed the typical triphasic release pattern. The addition of HA to the compositions increased the release rate of 5-FU from the scaffolds and improved the mechanical properties of the scaffolds, while it retarded the degradation of PLGA. Therefore, NCDS could be a good system to prepare polymeric implants of various shapes with different drug release patterns.
Lee
Jae-Hoon
JH
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
Ha
Won-Shik
WS
Chu
Won-Shik
WS
Park
Chun-Woong
CW
Ahn
Sung-Hoon
SH
Chi
Sang-Cheol
SC
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004337:Drug Carriers; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D004548:Elasticity; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry; D006244:Hardness; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D004337:Drug Carriers; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite; D005472:Fluorouracil