title: An open-label pilot study to evaluate the efficacy and tolerability of a silicone gel in the treatment of hypertrophic scars using clinical and ultrasound assessments.
abstract: Silicone gel sheets and intralesional corticosteroids are effective treatments for hypertrophic scars according to evidence studies. The aim of this study was to evaluate, both clinically and by ultrasound, the efficacy and tolerability of a topical self-drying silicone gel containing polysiloxane and silicone dioxide applied twice daily in eight hypertrophic scars. After 6 months all lesions showed evident clinical and/or ultrasound improvement, with a mean scar thickness reduction of 37% (range 20-54%). Although controlled trials in larger series of patients are necessary, our results suggest that the self-drying silicone gel may represent a safe and effective treatment for hypertrophic scars.
authors.affiliation: Dermatology Clinic, University of Catania, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lacarrubba
authors.forename: Lara
authors.initials: L
authors.lastname: Patania
authors.forename: Rosario
authors.initials: R
authors.lastname: Perrotta
authors.forename: Giorgio
authors.initials: G
authors.lastname: Stracuzzi
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Nasca
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Micali
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002648:Child; D017439:Cicatrix, Hypertrophic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020034:Silicone Gels / Q000627:therapeutic use*; D012867:Skin / Q000000981:diagnostic imaging / Q000473:pathology / Q000648:ultrastructure; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D020034:Silicone Gels