title: Potential basis for amphotericin B resistance in Aspergillus terreus.
abstract: This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.
authors.affiliation: Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Blum
authors.forename: Susanne
authors.initials: S
authors.lastname: Perkhofer
authors.forename: Hubertus
authors.initials: H
authors.lastname: Haas
authors.forename: Markus
authors.initials: M
authors.lastname: Schrettl
authors.forename: Reinhard
authors.initials: R
authors.lastname: Würzner
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Dierich
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis; D001230:Aspergillus / Q000145:classification* / Q000187:drug effects* / Q000201:enzymology; D002374:Catalase / Q000096:biosynthesis*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D002374:Catalase