[Our experiences with therapeutic hypothermia].
BACKGROUND
The single most important clinically relevant cause of global cerebral ischemia is cardiac arrest. The estimated rate of sudden cardiac arrest is between 40 and 130 cases per 100.000 people per year. Almost 80% of patients initially resuscitated from cardiac arrest remain comatose for more than one hour. One year after cardiac arrest only 10-30% of these patients survive with good neurological outcome. The ability to survive anoxic no-flow states is dramatically increased with protective and preservative hypothermia. The results of clinical studies show a marked neuroprotective effect of mild hypothermia in resuscitation.


METHODS
In our clinic, 12 patients were treated with therapeutic hypothermia. A combination of intravascular and external method of cooling was used according to the ILCOR (International Liaison Committee on Resuscitation) guidelines. The target temperature was 33 degrees C, while the duration of cooling was 24 hours. After that, passive rewarming was allowed. All patients also received other necessary therapy.


RESULTS
Six patients (50%) had a complete neurological recovery. Two patients (16.6%) had partial neurological recovery. Four patients (33.3%) remained comatose. Five patients (41.66%) survived, while 7 (58.33%) patients died. The main cause of cardiac arrest was acute myocardial infarction (91.6%). One patient had acute myocarditis.


CONCLUSIONS
Mild resuscitative hypothermia after cardiac arrest improves neurological outcome and reduces mortality in comatose survivors.
Petrović
Milovan
M
Institut za kardiovaskularne bolesti, 21204 Sremska Kamenica, Klinka za kardiologiju. nsbim@EUnet.yu
Srdanović
Ilija
I
Panić
Gordana
G
Canji
Tibor
T
Miljević
Tihomir
T
D003128:Coma / Q000209:etiology / Q000628:therapy; D006323:Heart Arrest / Q000150:complications / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced; D012151:Resuscitation; D015996:Survival Rate