The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems.
Substantial evidence indicates that brain neurons containing and secreting noradrenaline and corticotropin-releasing factor (CRF) are activated during stress, and that physiological and behavioural responses observed during stress can be induced by exogenous administration of CRF and adrenoceptor agonists. This review focusses on the evidence for the involvement of these two factors in stress-related responses, and the inter-relationships between them. The possible abnormalities of these two systems in depressive illness are also discussed.
Dunn
Adrian J
AJ
Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA. ajdunn@hawaii.edu
Swiergiel
Artur H
AH
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology; D019964:Mood Disorders / Q000503:physiopathology; D009638:Norepinephrine / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*
D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine