title: Adenocarcinoma arising from chronic perianal Crohn's disease: case report and review of the literature.
abstract: Perianal disease is a common manifestation of Crohn's disease. Rarely malignancy arises in perianal fistulas. The etiology of fistula related cancer remains a subject of debate. We present a unique case of a perianal Crohn's disease with adenomatous epithelialization of a fistula tract and an associated mucinous adenocarcinoma. Our case demonstrates that mucinous adenocarcinoma can arise in long standing perianal Crohn's disease and may be associated with adenomatous transformation of the epithelial lining of the fistula tract.
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Smith
authors.forename: David
authors.initials: D
authors.lastname: Hicks
authors.forename: Paul I
authors.initials: PI
authors.lastname: Tomljanovich
authors.forename: Shashikant B
authors.initials: SB
authors.lastname: Lele
authors.forename: Ashwani
authors.initials: A
authors.lastname: Rajput
authors.forename: Kelli Bullard
authors.initials: KB
authors.lastname: Dunn
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001005:Anus Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002908:Chronic Disease; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D012003:Rectal Fistula / Q000209:etiology* / Q000473:pathology / Q000601:surgery