Anti-BK virus activity of nucleoside analogs.
Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.
Randhawa
Parmjeet
P
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA. randhawapa@upmc.edu
Zemlicka
Jiri
J
Sauerbrei
Andreas
A
Meier
Chris
C
Hostetler
Karl Y
KY
Beadle
James R
JR
Farasati
Noush Afarin
NA
Huang
Yuchen
Y
Bradley
Matthews
M
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D001739:BK Virus / Q000187:drug effects* / Q000502:physiology; D004952:Esters / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D004952:Esters; D005227:Fatty Acids; D009705:Nucleosides; D063065:Organophosphonates; C053001:adefovir; C050127:9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine; D000225:Adenine