title: A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes.
abstract: Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.
authors.affiliation: Division of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm. 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA. chunming@ucsd.edu
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Huang
authors.forename: Justin W
authors.initials: JW
authors.lastname: Torpey
authors.forename: Yu-Tseung
authors.initials: YT
authors.lastname: Liu
authors.forename: Yun-Ru
authors.initials: YR
authors.lastname: Chen
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Williams
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Komives
authors.forename: Richard L
authors.initials: RL
authors.lastname: Gallo
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D005260:Female; D005973:Glutamine / Q000737:chemistry; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011392:Proline / Q000737:chemistry; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000254:growth & development; D012463:Saliva / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D010455:Peptides; D012471:Salivary Proteins and Peptides; D005973:Glutamine; D011392:Proline