Clinical pharmacology of cancer therapies in older adults.
This abbreviated review outlines the physiologic changes associated with aging, and examines how these changes may affect the pharmacokinetics and pharmacodynamics of anticancer therapies. We also provide an overview of studies that have been conducted evaluating the pharmacology of anticancer therapies in older adults, and issue a call for further research.
Hurria
A
A
The Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA. ahurria@coh.org
Lichtman
S M
SM
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology; D002986:Clinical Trials as Topic; D006801:Humans
D000970:Antineoplastic Agents