title: [The values of (11)C-acetate and (18)F-fluorodeoxyglucose positron emission tomography in diagnosis of indefinite liver masses].
abstract: OBJECTIVE
  To evaluate the values of the two tracers of positron emission tomography (PET) in the liver masses not definitely diagnosed by routine examinations.
  
  
  METHODS
  Fifteen patients with liver masses of indefinite diagnosis after serum tests and common imaging examinations underwent PET with both (11)C-acetate and (18)F-fluorodeoxyglucose (FDG). The results were compared. After the PET all 15 patients were subjected to surgery.
  
  
  RESULTS
  Pathological examination showed that 13 of the 15 patients were confirmed as malignant liver lesions and the other 2 as benign. Within the 13 malignant liver lesions, (11)C-acetate-PET suggested malignancy in 10 cases, and benignancy in 3 cases. And (18)F-FDG-PET suggested malignancy in 9 cases and benignancy in 4 cases. In the two benign cases, both (11)C-acetate-PET and (18)F-FDG-PET showed one malignant liver lesion and one benign liver lesion. (11)C-acetate-PET showed a high sensitivity (100%) for the well-differentiated tumors, and (18)F-FDG-PET showed a high sensitivity for the poorly-differentiated tumors.
  
  
  CONCLUSIONS
  The diagnostic accuracy for liver lesions may be improved by the two tracers of PET when the lesions can not be definitely diagnosed by routine examinations and at the same time when the patients are able to afford two PET examinations. They may also imply the cell-differentiation of the liver masses, and be helpful for selecting the treatment means for the patients.
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China.
authors.forename: Xin-Ting
authors.initials: XT
authors.lastname: Sang
authors.forename: Shun-da
authors.initials: SD
authors.lastname: DU
authors.forename: Yi-Lei
authors.initials: YL
authors.lastname: Mao
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Huo
authors.forename: Shou-Xian
authors.initials: SX
authors.lastname: Zhong
authors.forename: Jie-Fu
authors.initials: JF
authors.lastname: Huang
mesh_terms: D000085:Acetates; D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D019788:Fluorodeoxyglucose F18