Nuclear factor kappa B and hepatitis viruses.
BACKGROUND
Hepatitis can be caused by a number of viruses, which have similar clinical manifestations and render infected individuals at high risk of death from cirrhosis and liver cancer. Current therapies for hepatitis have limited effects and unsatisfactory patient outcomes. Nuclear factor kappa B (NF-kappaB) is critical for immune and inflammatory responses. During its lifetime the cell demands specific and highly regulated control of NF-kappaB activity.


OBJECTIVE
To develop novel strategies to overcome various hepatitides and related liver cancer with NF-kappaB as the key point.


METHODS
All aspects of NF-kappaB control with regard to hepatitis are covered.


CONCLUSIONS
NF-kappaB plays an important role in the process of hepatitis and is hypothesized to be an anti-cancer factor in the subsequent inflammation-associated hepatocarcinogenesis.
Guan
Yong-Song
YS
West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. yongsongguan@yahoo.com
He
Qing
Q
Wang
Ming-Quan
MQ
Li
Ping
P
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D006518:Hepatitis Viruses / Q000187:drug effects / Q000502:physiology*; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000276:immunology; D016328:NF-kappa B / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D016328:NF-kappa B