title: Correlation of optic nerve sheath diameter with direct measurement of intracranial pressure.
abstract: BACKGROUND
  Measurements of the optic nerve sheath diameter (ONSD) using bedside ultrasound (US) have been shown to correlate with clinical and radiologic signs and symptoms of increased intracranial pressure (ICP).
  
  
  OBJECTIVE
  Previous literature has identified 5 mm as the ONSD measurement above which patients exhibit either clinical or radiologic signs of elevated ICP. The goals of this study were to evaluate the association between ONSD and ICP and to validate the commonly used ONSD threshold of 5 mm using direct measurements of ICP as measured by ventriculostomy.
  
  
  METHODS
  A prospective blinded observational study was performed using a convenience sample of adult patients in both the emergency department (ED) and the neurologic intensive care unit (ICU) who had invasive intracranial monitors placed as part of their clinical care. Ocular USs were performed with a 10(-5) MHz linear probe. Emergency physicians (EPs) with previous ocular US experience performed ONSD measurements while blinded to the contemporaneous ICP reading obtained directly from invasive monitoring. The association between ONSD and ICP was assessed with the Spearman rank correlation coefficient, and a receiver operator characteristic (ROC) curve was created to determine the optimal ONSD cutoff to detect ICP > 20 cm H2O.
  
  
  RESULTS
  Thirty-eight ocular USs were performed on 15 individual patients. Spearman rank correlation coefficient of ONSD and ICP was 0.59 (p < 0.0005) demonstrating a significant positive correlation. An ROC curve was created to assess the ability of ONSD to distinguish an abnormal ICP greater than 20 cm H2O. The area under the ROC curve was 0.93 (95% confidence interval [CI] = 0.84 to 0.99). Based on inspection of the ROC curve, ONSD > 5 mm performed well to detect ICP > 20 cm H(2)O with a sensitivity of 88% (95% CI = 47% to 99%) and specificity of 93% (95% CI = 78% to 99%).
  
  
  CONCLUSIONS
  Using an ROC curve the authors systematically confirmed the commonly used threshold of ONSD > 5 mm to detect ICP > 20 cm H2O. This study directly correlates ventriculostomy measurements of ICP with US ONSD measurements and provides further support for the use of ONSD measurements as a noninvasive test for elevated ICP.
authors.affiliation: Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA. hkimberly@partners.org
authors.forename: Heidi Harbison
authors.initials: HH
authors.lastname: Kimberly
authors.forename: Sachita
authors.initials: S
authors.lastname: Shah
authors.forename: Keith
authors.initials: K
authors.lastname: Marill
authors.forename: Vicki
authors.initials: V
authors.lastname: Noble
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D016037:Single-Blind Method; D014463:Ultrasonography; D014505:Urban Population; D014696:Ventriculostomy; D014947:Wounds and Injuries / Q000150:complications