title: [A patient under hemodialysis with acute distal ischaemia: cholesterol crystal embolism].
abstract: A 61-year old man was admitted in our hospital for distal ischaemic lesions of the right foot with necrosis of the fifth toe. The lesions appeared a few days before admission. He was known for severe atheromatous disease and multiple aortic and femoro-popliteous aneurysms. He presented also numerous cardiovascular risk factors and a terminal chronic kidney disease was found 18 months earlier. The etiology of the kidney disease was not clear. The patient received hemodialysis since one month. We suspected a severe peripheral arterial disease but the investigations showed preserved distal arterial blood flow what made us think about a thromboembolic disease. We ruled out a potential embolic cardiopathy and, after finding eosinophilia and a previous consultation report of livedo, we suggested the diagnosis of cholesterol crystal embolisation. It was confirmed by the macroscopic examination of the necrotic toe. It's a rare and under-diagnosed pathology with a variable presentation. Though, it's important to detect this affection early as possible to prevent the frequent recurrences. The acute mortality is about 15%. There is no specific treatment, but an an aggressive control of the atheromatous disease is important. We must also avoid the known potential triggering factors: vascular surgery, angiography and anticoagulant or thrombolytic medications.
authors.affiliation: Service de Médecine Interne, C.H.U. Charleroi, Site André Vésale, Montigny-le-Tilleul. f.mignon@ulb.ac.be
authors.forename: F
authors.initials: F
authors.lastname: Mignon
authors.forename: A
authors.initials: A
authors.lastname: Chaick
authors.forename: P
authors.initials: P
authors.lastname: Raynal
authors.forename: A
authors.initials: A
authors.lastname: Vereerstraeten
authors.forename: M
authors.initials: M
authors.lastname: Vanhaeverbeek
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D017700:Embolism, Cholesterol / Q000150:complications*; D006801:Humans; D007383:Intermittent Claudication / Q000209:etiology; D007511:Ischemia / Q000150:complications* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D006435:Renal Dialysis; D014034:Toes / Q000473:pathology
chemical_list: D000959:Antihypertensive Agents