[Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma].
OBJECTIVE
To investigate the relationship of angiogenesis and the Ang family members/ receptor (Ang/Tie2) in hemangioma.


METHODS
Expression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin.


RESULTS
The expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas (P < 0.01), and was rare or negative in normal skin. Expression of Ang1 was rare or negative both in hemangioma and normal skin without significant difference between them (P > 0.05).


CONCLUSIONS
Ang/Tie2 system may play an important role in the proliferating and involuting process of hemangioma.
Wang
Biao
B
Department of Plastic Surgery, Second Affiliated Hospital, Kunming Medical College, Kunming 650101, China.
Lu
Kai-hua
KH
Zhao
Ya-nan
YN
Zhuang
Fu-lian
FL
Hong
Fan
F
Lin
Wen-xiong
WX
Lin
Jing-an
JA
Zhang
Sheng
S
D042683:Angiopoietin-1 / Q000378:metabolism*; D042702:Angiopoietin-2 / Q000378:metabolism*; D002675:Child, Preschool; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D042787:Receptor, TIE-2 / Q000378:metabolism*
D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042787:Receptor, TIE-2