Sugar-derived tricatenar catanionic surfactant: synthesis, self-assembly properties, and hydrophilic probe encapsulation by vesicles.
A new sugar-derived tricatenar catanionic surfactant (TriCat) was developed to obtain stable vesicles that could be exploited for drug encapsulation. The presence of the sugar moiety led to the formation of highly hydrophilic stoichiometric catanionic surfactant systems. The three hydrophobic chains permitted vesicles to form spontaneously. The self-assembly properties (morphology, size, and stability) of TriCat were examined in water and in buffer solution. Encapsulation studies of a hydrophilic probe, arbutin, commonly used in cosmetics for its whitening properties, were performed to check the impermeability of the vesicle bilayer. The enhancement of hydrophobic forces by the three chains of TriCat prevented surfactant equilibrium between the bilayer and the solution and enabled the probe to be retained in the aqueous cavity of the vesicles for at least 30 h. Thus, the present study suggests that this tricatenar catanionic surfactant could be a promising delivery system for hydrophilic drugs.
Soussan
Elodie
E
Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, UMR CNRS 5623, Université Paul Sabatier, 31062 Toulouse Cedex 4, France.
Mille
Caroline
C
Blanzat
Muriel
M
Bordat
Pascal
P
Rico-Lattes
Isabelle
I
D002214:Capsules / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D002412:Cations / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010316:Particle Size; D013499:Surface Properties; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D017155:Wettability
D002214:Capsules; D002241:Carbohydrates; D002412:Cations; D004337:Drug Carriers; D013501:Surface-Active Agents; D014867:Water