title: Prenatal magnetic resonance imaging of optic nerve head coloboma.
abstract: OBJECTIVE
  Congenital optic nerve head coloboma represents an important cause of childhood visual impairment and blindness; it can be isolated or, more often, it can be associated with several syndromes. Ultrasound has limitations in depicting the posterior aspect of the fetal eye globe, so prenatal information about ocular coloboma are very scarce. The purpose of this paper was to report prenatal magnetic resonance (MR) imaging features of optic nerve head coloboma.
  
  
  METHODS
  MR imaging at 1.5 Tesla was based on multiplanar single-shot fast spin-echo T2-weighted 3-4 mm thick contiguous sections.
  
  
  RESULTS
  Three fetal cases with optic nerve head coloboma and one with microphthalmos and colobomatous cyst are reported. Coloboma appeared as a focal bulging of ocular globe profile at the insertion of optic nerve.
  
  
  CONCLUSIONS
  Prenatal MR imaging allowed an accurate diagnosis to be obtained.
authors.affiliation: Radiology and Neuroradiology Department, Children's Hospital V. Buzzi, Milan, Italy. neurorad@icp.mi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Righini
authors.forename: Laura
authors.initials: L
authors.lastname: Avagliano
authors.forename: Chiara
authors.initials: C
authors.lastname: Doneda
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinelli
authors.forename: Cecilia
authors.initials: C
authors.lastname: Parazzini
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rustico
authors.forename: Fabio
authors.initials: F
authors.lastname: Triulzi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bulfamante
mesh_terms: D000328:Adult; D003103:Coloboma / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008279:Magnetic Resonance Imaging; D009898:Optic Disk / Q000002:abnormalities*; D011296:Prenatal Diagnosis