Total synthesis of an antigenic heptasaccharide motif found in the cell-wall lipooligosaccharide of Mycobacterium gordonae strain 989.
An antigenic heptasaccharide motif of the cell-wall glycolipid of Mycobacterium gordonae strain 989 has been synthesized in a linear fashion by using a general glycosylation condition and minimum number of protecting group manipulation. All suitably protected monosaccharide intermediates were prepared from commercially available reducing sugars following some novel methodologies recently developed in our laboratory. Most of the synthetic intermediates were obtained as solid compounds in excellent yields.
Mukherjee
Chinmoy
C
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, India.
Misra
Anup Kumar
AK
D000942:Antigens, Bacterial / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002473:Cell Wall / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry*; D009005:Monosaccharides / Q000737:chemistry; D009170:Nontuberculous Mycobacteria / Q000276:immunology*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D009005:Monosaccharides; D009844:Oligosaccharides; C023023:lipid-linked oligosaccharides