A preliminary study comparing the endometrial expression of inhibin, activin and follistatin in women with a history of implantation failure after IVF treatment and a control group.
The aim of this study was to evaluate the expression of activin: beta A and beta B subunit and follistatin in endometrium of women with implantation failure (n = 10) and compare it with a fertile control group (n = 7). Immunohistochemical staining intensity for follistatin in the endometrial glandular epithelium from women with implantation failure were significantly lower than that in control women (P = 0.03). The decreased expression of follistatin in epithelial cells in the endometrium of women with implantation failure after in vitro fertilisation (IVF) may suggest that follistatin may play a role in the implantation process.
Prakash
A
A
Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, UK. alkaprakash@hotmail.com
Tuckerman
E
E
Laird
S
S
Ola
B
B
Li
T C
TC
Ledger
W L
WL
D000328:Adult; D016022:Case-Control Studies; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D038681:Follistatin / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007247:Infertility, Female / Q000378:metabolism* / Q000628:therapy; D028322:Inhibin-beta Subunits / Q000378:metabolism*
D038681:Follistatin; C422402:INHBB protein, human; C103008:inhibin beta A subunit; D028322:Inhibin-beta Subunits