title: Ciliogenesis, ciliary function, and selective isolation.
abstract: In addition to their classic role in cell motility, certain cilia have sensory or signaling functions. In sea urchin embryos, short motile cilia randomly propel the early embryo, while a group of long, immotile cilia appear later, coincident with directional swimming and localized within a region that gives rise to the larval nervous system. Motile cilia can be selectively removed by treatment with a novel derivative of dillapiol, leaving the putative sensory cilia for comparative investigation and a gently deciliated embryo ready for studies of regeneration signaling.
authors.affiliation: Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA. rstephen@bu.edu
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Stephens
mesh_terms: D000498:Allyl Compounds; D000818:Animals; D002923:Cilia / Q000502:physiology*; D004149:Dioxoles / Q000494:pharmacology; D004625:Embryo, Nonmammalian / Q000502:physiology*; D004627:Embryonic Induction / Q000187:drug effects; D012038:Regeneration / Q000502:physiology*; D012617:Sea Urchins / Q000196:embryology*
chemical_list: D000498:Allyl Compounds; D004149:Dioxoles; C498255:5-allyl 6,7-dimethoxy 1,3-benzodioxole