title: Gray matter atrophy in patients with ischemic stroke with cognitive impairment.
abstract: OBJECTIVE
  Patients with ischemic stroke are at risk for developing vascular cognitive impairment ranging from mild impairments to dementia. MRI findings of infarction, white matter hyperintensities, and global cerebral atrophy have been implicated in the development of vascular cognitive impairment. The present study investigated regional gray matter volume differences between patients with ischemic stroke with no cognitive impairment and those with impairment in at least one domain of cognitive function.
  
  
  METHODS
  Ninety-one patients with ischemic stroke participated. Detailed neuropsychological testing was used to characterize cognitive functioning in 7 domains: orientation, attention, working memory, language, visuospatial ability, psychomotor speed, and memory. High-resolution T1-weighted 3-dimensional fast-spoiled gradient recalled structural MRIs were processed using optimized voxel-based morphometry techniques while controlling for lesions. Whole brain voxelwise regional differences in gray matter volume were assessed between patients with stroke with no impaired cognitive domains and patients with stroke with at least one impaired cognitive domain. Logistic regression models were used to assess the contribution of demographic variables, stroke-related variables, and voxel-based morphometry results to classification of cognitive impairment group membership.
  
  
  RESULTS
  Fifty-one patients had no impairments in any cognitive domain and 40 patients were impaired in at least one cognitive domain. Logistic regression identified significant contributions to cognitive impairment groups for demographic variables, stroke-related variables, and cognitive domain performance. Voxel-based morphology results demonstrated significant gray matter volume reductions in patients with stroke with one or more cognitive domain impairment compared with patients with stroke without cognitive impairment that was seen mostly in the thalamus with smaller reductions found in the cingulate gyrus and frontal, temporal, parietal, and occipital lobes. These reductions were present after controlling for group differences in age, education, stroke volume, and laterality of stroke. The addition of voxel-based morphometry-derived thalamic volume significantly improved a logistic regression model predicting cognitive impairment group membership when added to demographic variables, stroke-related variables, and cognitive domain performance.
  
  
  CONCLUSIONS
  These results suggest a central role for the thalamus and lesser roles for other cortical regions in the development of cognitive impairment after ischemic stroke. Indeed, consideration of thalamic volumes adds significant information to the classification of cognitive impaired versus nonimpaired groups beyond information provided by demographic, stroke-related, and cognitive performance measures.
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison, Suite 309, Chicago, IL 60612, USA. gstebbin@rush.edu
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Stebbins
authors.forename: David L
authors.initials: DL
authors.lastname: Nyenhuis
authors.forename: Changsheng
authors.initials: C
authors.lastname: Wang
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Cox
authors.forename: Sally
authors.initials: S
authors.lastname: Freels
authors.forename: Katherine
authors.initials: K
authors.lastname: Bangen
authors.forename: Leyla
authors.initials: L
authors.lastname: deToledo-Morrell
authors.forename: Kumar
authors.initials: K
authors.lastname: Sripathirathan
authors.forename: Michael
authors.initials: M
authors.lastname: Moseley
authors.forename: David A
authors.initials: DA
authors.lastname: Turner
authors.forename: John D E
authors.initials: JD
authors.lastname: Gabrieli
authors.forename: Philip B
authors.initials: PB
authors.lastname: Gorelick
mesh_terms: D002545:Brain Ischemia / Q000150:complications*; D002540:Cerebral Cortex / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D010487:Periaqueductal Gray / Q000473:pathology*; D020521:Stroke / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D013788:Thalamus / Q000473:pathology