title: [Chronic granulomatous disease recognised in 42-years-old patient].
abstract: Chronic granulomatous disease (CGD) comprises a heterogeneous group of diseases that are caused by defect in the superoxide-producing NADPH oxidase of neutrophils. This defect impairs the intracellular killing of microorganisms. Typical manifestations are recurrent bacterial or mycotic infections affecting the lungs, skin, lymph nodes and gastrointestinal tract (liver). Chronic granulomatous disease could be diagnosed on the basis of the anamnesis, clinical picture and results of granulocyte function tests showing impaired phagocytic activity (NBT tests, RDH test and a deficit of superoxide production). Typically symptoms of disease occur in the first years of live, leading often to death in the 2. or 3. decade. Below we present a patient, in whom diagnosis of the CGD was established at the age of 42.
authors.affiliation: III Klinika Chorób Płuc, Instyutu Gruźlicy i Chorób Płuc w Warszawie, Warszawa.
authors.forename: Justyna
authors.initials: J
authors.lastname: Fijołek
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wiatr
authors.forename: Dariusz
authors.initials: D
authors.lastname: Gawryluk
authors.forename: Iwona
authors.initials: I
authors.lastname: Bestry
authors.forename: Ewa
authors.initials: E
authors.lastname: Bernatowska
authors.forename: Waldemar
authors.initials: W
authors.lastname: Jabłoński
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Roszkowski-Sliz
mesh_terms: D000328:Adult; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging*; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D011859:Radiography; D013481:Superoxides / Q000378:metabolism*
chemical_list: D013481:Superoxides; D019255:NADPH Oxidases