title: Catalytic asymmetric total synthesis of (+)-yohimbine.
abstract: The total synthesis of (+)-yohimbine was achieved in 11 steps and 14% overall yield. The absolute configuration was established through a highly enantioselective thiourea-catalyzed acyl-Pictet-Spengler reaction, and the remaining 4 stereocenters were set simultaneously in a substrate-controlled intramolecular Diels-Alder reaction.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Dustin J
authors.initials: DJ
authors.lastname: Mergott
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Zuend
authors.forename: Eric N
authors.initials: EN
authors.lastname: Jacobsen
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D015016:Yohimbine / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D015016:Yohimbine