[Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism].
We carried out comparison of distribution of alleles and genotypes of polymorphic loci of renin-angiotensin-aldosterone system genes: CYP11B2 (C-344T), AGT (Thr174Met) and REN (C-5434T, C-5312T, and A BglI G) and their combinations in two groups of patients with low renin forms of arterial hypertension (AH). Group 1 included 59 patients with low renin hyperaldosteronism (HA) at the background of glomerular zone adenoma and hyperplasia of adrenal cortex. Group 2 included 28 patients with low renin hypertensive disease characterized by normal level of aldosterone. Complex analysis of carriership of allele and genotype combinations evidence for the difference in genetic nature of two forms of low renin AH. Participation of CYP11B2 and REN and possibly AGT genes in development of low renin AH was convincingly shown.
Chikhladze
N M
NM
Samedova
Kh F
KhF
Sudomoina
M A
MA
Thant
Myo
M
Htut
Zaw Min
ZM
Litonova
G N
GN
Favorov
A V
AV
Chazova
I E
IE
Favorova
O O
OO
D000483:Alleles; D000808:Angiotensinogen / Q000097:blood / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D019405:Cytochrome P-450 CYP11B2 / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications* / Q000235:genetics; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012083:Renin / Q000097:blood / Q000235:genetics*
D015415:Biomarkers; D000808:Angiotensinogen; D004247:DNA; D019405:Cytochrome P-450 CYP11B2; D012083:Renin