Effects interferon-2alpha on seizures in corasol-induced kindling.
Intracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.
Kresyun
V I
VI
Odessa State Medical University, Ukraine.
Kobolev
E V
EV
Smirnov
I V
IV
Godovan
V V
VV
Godlevskii
L S
LS
D000818:Animals; D004569:Electroencephalography / Q000187:drug effects; D016898:Interferon-alpha / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D016898:Interferon-alpha; D010433:Pentylenetetrazole