Adenocarcinoma arising from chronic perianal Crohn's disease: case report and review of the literature.
Perianal disease is a common manifestation of Crohn's disease. Rarely malignancy arises in perianal fistulas. The etiology of fistula related cancer remains a subject of debate. We present a unique case of a perianal Crohn's disease with adenomatous epithelialization of a fistula tract and an associated mucinous adenocarcinoma. Our case demonstrates that mucinous adenocarcinoma can arise in long standing perianal Crohn's disease and may be associated with adenomatous transformation of the epithelial lining of the fistula tract.
Smith
Richard
R
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Hicks
David
D
Tomljanovich
Paul I
PI
Lele
Shashikant B
SB
Rajput
Ashwani
A
Dunn
Kelli Bullard
KB
D002288:Adenocarcinoma, Mucinous / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001005:Anus Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002908:Chronic Disease; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D012003:Rectal Fistula / Q000209:etiology* / Q000473:pathology / Q000601:surgery