The cholecystokinin type A receptor g.179A>G polymorphism affects feeding rate.
A polymorphism within the 5' untranslated region of the cholecystokinin type A receptor (CCKAR) gene has been shown to affect feed intake and growth in commercial pig lines. To further investigate the phenotype of animals carrying alternative alleles at this polymorphism, we genotyped animals from a distinct segregating commercial line and an experimental cross F(2) population, both with electronically recorded feeding pattern data. The data indicate that the daily feed intake increasing effect of the DQ496228:g.179G allele is mediated through a faster rate of feed intake, without evidence for an effect on other feeding behaviour traits.
Houston
R D
RD
Division of Genetics and Genomics, Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, UK. ross.houston@bbsrc.ac.uk
Rance
K A
KA
Sutcliffe
E
E
Archibald
A L
AL
Haley
C S
CS
D020121:5' Untranslated Regions / Q000235:genetics*; D000818:Animals; D003433:Crosses, Genetic; D002149:Energy Intake; D005247:Feeding Behavior / Q000502:physiology*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D043886:Receptor, Cholecystokinin A / Q000235:genetics*; D012528:Satiety Response / Q000502:physiology; D013552:Swine / Q000235:genetics* / Q000254:growth & development
D020121:5' Untranslated Regions; D043886:Receptor, Cholecystokinin A