Gastroretentive drug delivery system of DA-6034, a new flavonoid derivative, for the treatment of gastritis.
A gastroretentive drug delivery system of DA-6034, a new synthetic flavonoid derivative, for the treatment of gastritis was developed by using effervescent floating matrix system (EFMS). The therapeutic limitations of DA-6034 caused by its low solubility in acidic conditions were overcome by using the EFMS, which was designed to cause tablets to float in gastric fluid and release the drug continuously. The release of DA-6034 from tablets in acidic media was significantly improved by using EFMS, which is attributed to the effect of the solubilizers and the alkalizing agent such as sodium bicarbonate used as gas generating agent. DA-6034 EFMS tablets showed enhanced gastroprotective effects in gastric ulcer-induced beagle dogs, indicating the therapeutic potential of EFMS tablets for the treatment of gastritis.
Jang
Sun Woo
SW
Research Laboratory, Dong-A Pharmaceutical Company, 47-5 Sanggal-dong, Kiheung-ku, Yongin 446-905, South Korea.
Lee
Jung Woo
JW
Park
Sung Hyun
SH
Kim
Jeong Hoon
JH
Yoo
Moohi
M
Na
Dong Hee
DH
Lee
Kang Choon
KC
D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004285:Dogs; D005079:Excipients / Q000737:chemistry*; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry; D005756:Gastritis / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D005079:Excipients; D005419:Flavonoids; D005765:Gastrointestinal Agents; D013607:Tablets; C121889:recoflavone