Effects of tryptophan depletion on cognitive functioning, obsessive-compulsive symptoms and mood in obsessive-compulsive disorder: preliminary results.
BACKGROUND
Previous studies suggest that obsessive-compulsive disorder (OCD) is associated with moderate cognitive deficits. There is also evidence for altered serotonergic transmission in OCD. The aim of this study was to evaluate the impact of rapid plasma tryptophan depletion on cognitive functioning in OCD.


METHODS
A double-blind crossover study was conducted to explore the effects of tryptophan depletion on cognitive functioning, obsessive or compulsive (OC) symptoms and mood in OCD patients treated with selective serotonin reuptake inhibitors.


RESULTS
After 5 h of tryptophan depletion, 6 out of 7 patients reported worsening of mood (placebo condition: 3 patients). No effect was found regarding OC symptoms. There was a small and nonsignificant improvement of nonverbal memory and fluency. Problem solving ability and verbal memory, in contrast, were slightly impaired after tryptophan depletion. The results, however, represented only tendencies without reaching significance.


CONCLUSIONS
The results suggest that OC symptoms may not depend on the short-time availability of serotonin. As some critical cognitive functions improved following tryptophan depletion, there is no evidence from our study that neuropsychological impairment in OCD can be reduced to a lowered level of serotonin. Future studies are needed to further clarify these findings by use of larger samples.
Külz
Anne Katrin
AK
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany. Anne.Katrin.Kuelz@uniklinik-freiburg.de
Meinzer
Sandra
S
Kopasz
Marta
M
Voderholzer
Ulrich
U
D000328:Adult; D000339:Affect; D001007:Anxiety / Q000097:blood; D003071:Cognition / Q000502:physiology*; D018592:Cross-Over Studies; D003863:Depression / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D014364:Tryptophan / Q000097:blood / Q000172:deficiency*
D017367:Selective Serotonin Reuptake Inhibitors; D014364:Tryptophan