Preventing intraperitoneal adhesions with vitamin E and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats.
OBJECTIVE
To compare the effectiveness of intraperitoneally administered vitamin E with the sodium hyaluronate/carboxymethylcellulose membrane (HA/CBMC) in preventing postoperative intraperitoneal adhesion formation.


METHODS
Sixty Wistar rats underwent a laparotomy and adhesions were induced (IA). The animals were divided into four groups: group 1, control (IA); group 2 (IA + Vitamin E): group 3 (IA+HA/CBMC) and group 4 (IA+ Vitamin E + HA/CBMC). The Vitamin E (groups 2 and 4) and HA/CBMC (groups 3 and 4) were administered intraperitoneally before the abdominal wall was closed. After 30 days, adhesions were classified by an independent surgeon.


RESULTS
Three animals died; one from group 3 and two from group 4. All control animals had substantial adhesions compared with unsubstantial adhesions observed in 11/15 in group 2 (P = 0.000), 11/14 in group 3 (P = 0.001), and 10/13 in group 4 (P = 0.000).


CONCLUSIONS
Vitamin E, administered intraperitoneally, is as effective as HA/CBMC in preventing postoperative adhesions.
Corrales
Fredy
F
HG, UCS, Caxias do Sul, Brazil. clindig@uol.com.br
Corrales
Marcelo
M
Schirmer
Carlos Cauduro
CC
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008297:Male; D010532:Peritoneal Diseases / Q000473:pathology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control; D014810:Vitamin E / Q000008:administration & dosage*
D000975:Antioxidants; D014810:Vitamin E; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium