title: Early hemispherotomy in a patient with multilobar cortical dysplasia with intractable seizure: clinical-neurophysiological study.
abstract: We present a patient with multilobar cortical dysplasia who underwent hemispherotomy, a modified functional hemispherectomy, at the age of 2 months because of intractable seizures and report the clinical-neurophysiological findings including EEG and somatosensory evoked potentials (SEP). After hemispherotomy, the seizures and EEG abnormality disappeared completely and postoperative SEP showed an ipsilateral cortical response at the unaffected hemisphere, suggesting a reorganization process, which was possibly facilitated more intensively after surgery. Furthermore, developmental catch-up was observed. Our patient's clinical course and neurophysiological data suggested that very early hemispherotomy resulted in not only the control of seizures but also a better developmental outcome.
authors.affiliation: Department of Pediatrics, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan. mkmegped@opal.plala.or.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Kubota
authors.forename: Keiji
authors.initials: K
authors.lastname: Goishi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takemura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kawai
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Arai
mesh_terms: D001921:Brain / Q000601:surgery*; D002540:Cerebral Cortex / Q000002:abnormalities / Q000254:growth & development / Q000601:surgery; D002657:Child Development; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D007223:Infant; D008279:Magnetic Resonance Imaging; D054220:Malformations of Cortical Development / Q000150:complications / Q000601:surgery*; D019635:Neurosurgical Procedures; D012640:Seizures / Q000209:etiology*; D017287:Ventriculoperitoneal Shunt