title: Interaction of nanoparticles with lipid membrane.
abstract: A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the l-alpha-dimyristoyl phosphatidylcholine membrane around 1.2-22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle-lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Roiter
authors.forename: Maryna
authors.initials: M
authors.lastname: Ornatska
authors.forename: Aravind R
authors.initials: AR
authors.lastname: Rammohan
authors.forename: Jitendra
authors.initials: J
authors.lastname: Balakrishnan
authors.forename: David R
authors.initials: DR
authors.lastname: Heine
authors.forename: Sergiy
authors.initials: S
authors.lastname: Minko
mesh_terms: D008051:Lipid Bilayers / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*
chemical_list: D008051:Lipid Bilayers