Thrombophilia in the young.
Venous thromboembolism (VTE) is a rare disease that is being increasingly diagnosed and recognized in paediatrics in the past decade, usually as a secondary complication of primary severe underlying diseases. Apart from acquired thrombophilic risk factors, such as lupus anticoagulants, inherited thrombophilias (IT) have been established as risk factors for venous thromboembolic events in adults. In children with idiopathic VTE and in paediatric populations in which thromboses were associated with underlying medical diseases, IT have been described as additional prothrombotic risk factors. Follow-up data for VTE recurrence in children are available and suggest a recurrence rate of approximately 3% in neonates and 8% in other children. Here we present a review of the impact of IT on early onset of VTE and recurrence in children. Statistically significant associations between the IT traits investigated, e.g. factor V G1691A, factor II G20210A, protein C-, protein S-, antithrombin deficiency, elevated lipoprotein (a), combined IT and VTE onset were reported. In addition, statistically significant associations with recurrent VTE were calculated for protein S-, antithrombin-deficiency, and the factor II variant and combined IT. The absolute risk increase for VTE recurrence associated with IT ranged from 9.8 % for children carrying the factorII variant to 26% and 29% in children with combined IT and protein S-deficiency, respectively. Data obtained gave evidence that the detection of IT is clinically meaningful in children with VTE and underlines the importance of a paediatric thrombophilia screening program. Based on these data treatment algorithms have to be discussed.
Nowak-Göttl
U
U
Univ. Children Hospital, Pediatric Hematology and Oncology, Albert-Schweitzer-Str. 33, 48149 Münster, Germany. leagottl@uni-muenster.de
Kurnik
K
K
Krümpel
A
A
Stoll
M
M
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D011627:Puberty; D011859:Radiography; D018570:Risk Assessment; D019851:Thrombophilia / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy; D014463:Ultrasonography
D000925:Anticoagulants