title: Desymmetrization of a meso-allylic acetal by enantioselective conjugate elimination.
abstract: An unprecedented enantioselective deprotonation/conjugate elimination sequence, which transforms an allylic meso-dioxepane into a chiral diene, is described. The best desymmetrization conditions (ee up to 70%) involve s-BuLi and sparteine at -78 degrees C in THF.
authors.affiliation: Laboratoire des Fonctions Azotées et Oxygénées Complexes de l'IRCOF, UMR CNRS 6014, Université et INSA de Rouen, 76821 Mont Saint-Aignan Cedex, France.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Thomas
authors.initials: T
authors.lastname: Regnier
authors.forename: Loïc
authors.initials: L
authors.lastname: Lemiègre
authors.forename: Pascal
authors.initials: P
authors.lastname: Cardinael
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Combret
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouillon
authors.forename: Jérome
authors.initials: J
authors.lastname: Blanchet
authors.forename: Jacques
authors.initials: J
authors.lastname: Rouden
authors.forename: Anne
authors.initials: A
authors.lastname: Harrison-Marchand
authors.forename: Jacques
authors.initials: J
authors.lastname: Maddaluno