title: Some considerations about the hydrophilic-lipophilic balance system.
abstract: The methods and results obtained by Griffin et al. in the determination of the hydrophilic-lipophilic balance (HLB) values of non-ionic surfactants and of required HLB values of oil mixtures are reviewed in the present work. HLB values published by Griffin were compared with those obtained by calculations from theoretic chemical formulas. Griffin HLB values of polyoxyethylene alkyl ethers, polyoxyethylene monoesters and propylene glycol monoesters coincide with those obtained from such theoretical chemical formulations. These results demonstrate that, for these surfactants, Griffin did not experimentally obtain their HLB values, but instead calculated them from theoretic formulae. For the calculation of the HLB values of glycerol monostearate, sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters, Griffin's assumptions were possibly based upon the mean saponification values of the ester and the acid of the fatty acid. It is concluded that the HLB values of non-ionic surfactants were not rigorously defined. Moreover, Griffin could not demonstrate the validity of the assumption that individual required HLB values can be added up to obtain the overall required HLB value of an oil mixture. The HLB and required HLB values published by Griffin should only be taken as approximate guidelines.
authors.affiliation: Cátedra de Farmacotecnia I, Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 6o piso, 1113 Buenos Aires, Argentina. rcpasquali@yahoo.com
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Pasquali
authors.forename: Melina P
authors.initials: MP
authors.lastname: Taurozzi
authors.forename: Carlos
authors.initials: C
authors.lastname: Bregni
mesh_terms: D002626:Chemistry, Pharmaceutical; D057927:Hydrophobic and Hydrophilic Interactions; D011092:Polyethylene Glycols / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D011136:Polysorbates; D011409:Propylene Glycols; D013501:Surface-Active Agents; D011092:Polyethylene Glycols