A review of Kallmann syndrome: genetics, pathophysiology, and clinical management.
Kallmann syndrome is a genetic disorder with the hallmarks of anosmia and hypogonadotrophic hypogonadism. It has a male preponderance. With the elucidation of the genetic pathways involved, affected females and inheritance patterns are becoming more clearly identified. It is an eminently treatable disorder, but it must first be recognized by the physician. With treatment, favorable reproductive outcomes can be attained in addition to maturation of secondary sex characteristics.
Fechner
Adam
A
New Jersey Medical School-UMDNJ, Newark, New Jersey, USA.
Fong
Shirley
S
McGovern
Peter
P
D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D050172:Genes, X-Linked / Q000235:genetics; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D017436:Kallmann Syndrome / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D008297:Male
D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone