title: [Low flow anaesthesia with isoflurane and sevoflurane in the dog].
abstract: The aim of the present study was to compare the safety and efficacy of sevoflurane and isoflurane during low flow anaesthesia (fresh gas flow (FGF) 14 ml/kg/min) as well as to compare the consumption of both anaesthetics. Data were gathered from 60 dogs assigned for surgery under general anaesthesia with an expected duration of 75 minutes or longer. All dogs were induced with 0.6 mg/kg (maximum 25 mg) l-methadone and 1 mg/kg (maximum 25 mg) diazepam i.v.. Anaesthesia was maintained with isoflurane (group 1) or sevoflurane (group 2) in a mixture with 50% O2 and 50% N2O as carrier gases, under controlled ventilation. Monitoring included electrocardiogram, body temperature, the temperature of in- and exspired gases, arterial oxygen saturation, arterial blood pressure as well as a continuous monitoring of inhaled and exhaled gas concentrations (O2, N2O, CO2, isoflurane, sevoflurane). The consumption of isoflurane and sevoflurane as well as the dogs' recovery times were evaluated for both groups. In all groups the inspired oxygen concentrations ranged above the minimum value of 30 Vol% during low flow anaesthesia, with an arterial oxygen saturation above 97%. End tidal concentration of CO2, heart rate and arterial blood pressure were within the physiological ranges and showed no differences between the two groups. Recovery time was significantly shorter after sevoflurane compared to isoflurane anaesthesia, whilst the consumption of sevoflurane was higher than that of isoflurane. Sevoflurane appears to be as clinically safe as isoflurane in low flow anaesthesia. Even considering that sevoflurane is more expensive than isoflurane, the use of the low flow technique decreases the cost of anaesthesia due to the reduced volatile anaesthetic consumption.
authors.affiliation: Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover. sabine.kramer@tiho-hannover.de
authors.forename: Sabine
authors.initials: S
authors.lastname: Kramer
authors.forename: Hassan
authors.initials: H
authors.lastname: Alyakine
authors.forename: Ingo
authors.initials: I
authors.lastname: Nolte
mesh_terms: D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000592:standards; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D004285:Dogs / Q000502:physiology*; D004798:Enzymes / Q000097:blood; D005260:Female; D005740:Gases / Q000032:analysis; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000008:administration & dosage* / Q000592:standards; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage* / Q000592:standards; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane; D013997:Time Factors; D014508:Urea / Q000652:urine
chemical_list: D018685:Anesthetics, Inhalation; D004798:Enzymes; D005740:Gases; D008738:Methyl Ethers; D000077149:Sevoflurane; D014508:Urea; D003404:Creatinine; D007530:Isoflurane