Transfer of signs of aging to young mice by splenic lymphoid cells from old syngeneic donors.
Single intraperitoneal injection of splenic lymphoid cells from 20-month-old mice to 2-month-old syngeneic mice (similarly as 5-day injections of purified brain extract) leads to preterm (4 months earlier than in the control) appearance of aging factor in the blood (the main sign of old age). Combined injections of brain extract and splenic lymphoid cells led to the appearance of aging factor in the blood 5 months earlier than in the control.
Babaeva
A G
AG
Laboratory of Growth and Development, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow.
Zuev
V A
VA
D000375:Aging / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D049109:Cell Proliferation; D017710:Lymphocyte Transfusion; D051379:Mice; D008810:Mice, Inbred C57BL; D009457:Neuroglia / Q000166:cytology; D013154:Spleen / Q000166:cytology; D014185:Transplantation, Isogeneic