Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction.
BACKGROUND
The aim of this study was to examine whether genetic predisposition to high levels of coagulation factors influences the risk of developing fatal and non-fatal arterial cardiovascular events in men with a first myocardial infarction (MI).


METHODS
We performed a cohort study among 542 MI patients with a mean age of 56 years (range 32-70 years) at the time of the event. All of the men had a first MI between 1990 and 1996 and were followed until 1 September 2004. DNA was analyzed for polymorphisms of fibrinogen, prothrombin (factor II), factor V, factor VII and plasminogen activator inhibitor type 1, all of which are associated with gain of function of the protein. We collected information from hospital files and general practitioners on the occurrence of major arterial events.


RESULTS
In total, 254 major arterial cardiovascular events occurred during a median follow-up period of 11 years (range 0.2-15 years). The point estimates of the relative rates (RRs) of these events for the variant genotypes were all between 0.7 and 1.1 except for the prothrombin 20210A mutation: RR 1.8 (95% confidence interval 0.8-4.1).


CONCLUSIONS
These findings suggest that there is no association between coagulation factor polymorphisms, previously associated with plasma levels, and the risk of recurrent cardiovascular events.
van der Krabben
M D
MD
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Rosendaal
F R
FR
van der Bom
J G
JG
Doggen
C J M
CJ
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005340:Fibrinogen; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D012008:Recurrence; D012307:Risk Factors
D001779:Blood Coagulation Factors; D005340:Fibrinogen