title: Besides adhesion: new perspectives of integrin functions in angiogenesis.
abstract: During angiogenic remodelling in embryo and adult life, endothelial cells lining blood vessel walls dynamically modify their integrin-mediated adhesive contacts with the surrounding extracellular matrix. However, besides regulating cell adhesion and migration, integrins dynamically participate in a network with soluble molecules and their receptors. Angiogenesis is characterized by opposing autocrine and paracrine loops of growth factors and semaphorins that regulate the activation of integrins on the endothelial surface through tyrosine kinase receptors (TKR) and the neuropilin/plexin system. Moreover, pro- and anti-angiogenic factors can directly bind integrins and regulate endothelial cell behaviour. This review summarizes the recent progress in understanding the reciprocal interactions between integrins, TKR, and semaphorin receptors.
authors.affiliation: Department of Oncological Sciences, Institute for Cancer Research and Treatment, University of Torino, Sp 142, Km 3.95, 10060 Candiolo, Torino, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Serini
authors.forename: Lucia
authors.initials: L
authors.lastname: Napione
authors.forename: Marco
authors.initials: M
authors.lastname: Arese
authors.forename: Federico
authors.initials: F
authors.lastname: Bussolino
mesh_terms: D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D042783:Endothelial Cells / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D039961:Semaphorins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D042501:Angiogenic Proteins; D016023:Integrins; D039961:Semaphorins; D020794:Receptor Protein-Tyrosine Kinases