title: Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis.
abstract: Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregulation of p53 in mouse cryptorchidism. Furthermore, in vitro over-expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat-induced apoptosis with a marked impairment of p53 expression. These findings indicate that Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis.
authors.affiliation: Department of Histology and Embryology, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Bao
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Xinping
authors.initials: X
authors.lastname: Liu
authors.forename: Ruojun
authors.initials: R
authors.lastname: Xu
authors.forename: Rui-an
authors.initials: RA
authors.lastname: Wang
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D003456:Cryptorchidism / Q000378:metabolism; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012097:Repressor Proteins; D013090:Spermatocytes / Q000378:metabolism; D013091:Spermatogenesis; D013737:Testis / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C503336:Mta1 protein, mouse; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53