Protein targeting to ATP-dependent proteases.
ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.
Inobe
Tomonao
T
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Hogan 2-100 Northwestern University, Evanston, IL, USA.
Matouschek
Andreas
A
D049069:ATP-Dependent Proteases / Q000737:chemistry* / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport; D013379:Substrate Specificity; D025801:Ubiquitin / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D025801:Ubiquitin; D049069:ATP-Dependent Proteases; D046988:Proteasome Endopeptidase Complex