title: Lineage-specific amino acid substitutions in region 2 of the RNA polymerase sigma subunit affect the temperature of promoter opening.
abstract: Highly conserved amino acid residues in region 2 of the RNA polymerase sigma subunit are known to participate in promoter recognition and opening. We demonstrated that nonconserved residues in this region collectively determine lineage-specific differences in the temperature of promoter opening.
authors.affiliation: Institute of Molecular Genetics, Kurchatov Sq. 2, Moscow 123182, Russia.
authors.forename: N
authors.initials: N
authors.lastname: Barinova
authors.forename: E
authors.initials: E
authors.lastname: Zhilina
authors.forename: I
authors.initials: I
authors.lastname: Bass
authors.forename: V
authors.initials: V
authors.lastname: Nikiforov
authors.forename: A
authors.initials: A
authors.lastname: Kulbachinskiy
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism; D034301:Deinococcus / Q000201:enzymology / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D011401:Promoter Regions, Genetic; D012808:Sigma Factor / Q000235:genetics* / Q000378:metabolism*; D013696:Temperature; D013824:Thermus / Q000201:enzymology / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012808:Sigma Factor; D012321:DNA-Directed RNA Polymerases