title: [Levels of interleukin-1beta and tumor necrosis factor-alpha in patients with aggressive periodontitis].
abstract: OBJECTIVE
  To compare the levels of plasma IL-1beta,TNFalpha in aggressive periodontitis (AgP) patients and periodontally healthy subjects.
  
  
  METHODS
  Venous blood samples were collected from 56 AgP patients and 39 periodontally healthy controls. Clinical examination consisted of bleeding index (BI), probing depth(PD)attachment loss measurements (AL) and percentage of severe sites. Plasma levels of IL-1beta and TNF-alpha were determined using a high-sensitivity ELISA assay.
  
  
  RESULTS
  The concentrations of IL-1beta in AgP patients were significantly higher than those in healthy controls (7.23 ng/L vs 3.52 ng/L, P=0.003), which were positively correlated with BI, PD, AL and the percentage of severe sites (r=0.170, P=0.038; r=0.175, P=0.033; r=0.168, P=0.040; r=0.236, P=0.004). The difference between the levels of TNF-alpha in AgP patients and healthy controls was not observed (1.07 ng/L vs 1.06 ng/L, P=0.437). No correlations between the plasma level of TNF-alpha and the periodontal parameters were detected (r=0.023, P=0.808; r=0.025, P=0.782; r=0.075, P=0.407; r=0.049, P=0.586).
  
  
  CONCLUSIONS
  AgP may have impact on the elevation of plasma level of IL-1beta, while no association between AgP and plasma level of TNF-alpha was found.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Sun
authors.forename: Huan-Xin
authors.initials: HX
authors.lastname: Meng
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D010949:Plasma / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha