[Drug delivery systems for intraocular applications].
Numerous drug delivery systems (DDSs) can be used as intraocular tools to provide a sustained and calibrated release for a specific drug. Great progress has been made on the design, biocompatibility, bioavailability, and efficacy of DDSs. Although several of them are undergoing clinical trials, a few are already on the market and could be of a routine use in clinical practice. Moreover, miniaturization of the implants makes them less and less traumatic for the eye tissues and some DDSs are now able to target certain cells or tissues specifically. An overview of ocular implants with therapeutic application potentials is provided.
Bourges
J-L
JL
INSERM; CRC, UMRS 872 équipe 17, Physiopathologie des maladies oculaires: innovations thérapeutiques, Paris, France.
Touchard
E
E
Kowalczuk
L
L
Berdugo
M
M
Thomas-Doyle
A
A
Bochot
A
A
Gomez
A
A
Azan
F
F
Gurny
R
R
Behar-Cohen
F
F
D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004343:Drug Implants; D004867:Equipment Design; D005123:Eye / Q000187:drug effects*; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D008081:Liposomes; D008904:Miniaturization; D053758:Nanoparticles; D010316:Particle Size; D011108:Polymers; D019736:Prostheses and Implants; D014822:Vitreous Body / Q000187:drug effects / Q000473:pathology
D003692:Delayed-Action Preparations; D004343:Drug Implants; D008081:Liposomes; D011108:Polymers