title: Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.
abstract: To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
authors.affiliation: Center for Global Health and Diseases, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA. reb6@case.edu
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Blanton
authors.forename: Luciano K
authors.initials: LK
authors.lastname: Silva
authors.forename: Vanessa G
authors.initials: VG
authors.lastname: Morato
authors.forename: Antonio R
authors.initials: AR
authors.lastname: Parrado
authors.forename: Juarez P
authors.initials: JP
authors.lastname: Dias
authors.forename: Paulo R S
authors.initials: PR
authors.lastname: Melo
authors.forename: Eliana A G
authors.initials: EA
authors.lastname: Reis
authors.forename: Katrina A B
authors.initials: KA
authors.lastname: Goddard
authors.forename: Márcio R T
authors.initials: MR
authors.lastname: Nunes
authors.forename: Sueli G
authors.initials: SG
authors.lastname: Rodrigues
authors.forename: Pedro F C
authors.initials: PF
authors.lastname: Vasconcelos
authors.forename: Jesuina M
authors.initials: JM
authors.lastname: Castro
authors.forename: Mitermayer G
authors.initials: MG
authors.lastname: Reis
authors.forename: Maurício L
authors.initials: ML
authors.lastname: Barreto
authors.forename: M Glória
authors.initials: MG
authors.lastname: Teixeira
mesh_terms: D044383:Black People / Q000235:genetics; D001938:Brazil; D003715:Dengue / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007182:Income