Effect of citrocard on functional reserves of the heart under conditions of chronic stress.
Chronic stress exposure produces a damaging effect on the myocardium and reduces its functional (inotropic) reserves. Citrocard (50 mg/kg) and fenibut (50 mg/kg) prevent stress effects: animals receiving these preparations demonstrate higher contraction and relaxation rates and higher left-ventricular pressure during functional tests (volume load and maximum isometric load).
Perfilova
V N
VN
Department of Pharmacology and Biopharmacy, Department of Postgraduate Medical Training, Volgograd State Medical Academy.
Tyurenkov
I N
IN
Lebedeva
S A
SA
Volotova
E V
EV
Berestovitskaya
V M
VM
Vasil'eva
O S
OS
D000818:Animals; D004558:Electric Stimulation; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid