Cell sensitivity to reaferon in patients with renal cell cancer after reaferon therapy.
Individual sensitivity of blood neutrophils to IFN-alpha2a was studied in vitro in patients with renal cell cancer before and after the first course of reaferon therapy. Cell sensitivity changed after reaferon therapy in 85% patients. This necessitates evaluation of individual cell sensitivity not only before therapy, but also before the next course of therapy.
Shkapova
E A
EA
Krasnoyarsk Territorial Oncological Center, Siberian Division of Russian Academy of Medical Sciences, Krasnoyarsk. k_shkapova@mail.ru
Kurtasova
L M
LM
Savchenko
A A
AA
D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects*; D011994:Recombinant Proteins
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins