[Distribution of chemical elements in various parts of the heart of patients with acute heart failure].
By the method of autopsy in patients with ischemic heart disease (IHD) who died of acute heart failure we took samples of myocardium from 6 parts of the heart: left and right atrium, left and right ventricle, region of myocardial infarction, and scar of the left ventricle. Simultaneously we conducted histological study of these parts of myocardium. For the control we investigated content of chemical elements in myocardium of healthy victims of traffic accidents. By the method of roentgen fluorescent analysis with the use of synchrotron emission we detected content of 17 chemical elements: 4 macroelements (S, Cl, K, Ca) and 13 microelements (Cr, Mn, Fe, Ni, Cu, Zn, Se, Br, Rb, Sr, As, Mo, Hg). It was established that in patients with IHD who had died of acute heart failure content of Ca was elevated 4-8 fold in all parts of the heart. In infarction zone compared with other regions of the heart maximal quantity of Sr, Cr, Hg was contained. These elements can be looked upon as markers of infarction. In myocardium of patients with IHD especially in the zone of infarction elevation of activity of processes of lipid peroxidaton has been noted (calculated activity of malone aldehyde as example).
Okuneva
G N
GN
Cherniavskiĭ
A M
AM
Levicheva
E N
EN
Loginova
I Iu
IIu
Volkov
A M
AM
Kliver
E E
EE
Trunova
V A
VA
Zvereva
V V
VV
D000208:Acute Disease; D001344:Autopsy; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000032:analysis; D009206:Myocardium / Q000737:chemistry*; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology; D018497:Ventricular Dysfunction, Right / Q000453:epidemiology
D008315:Malondialdehyde