Non-melanoma skin cancer: importance of gender, immunosuppressive status and vitamin D.
Ultraviolet light B (UVB) is responsible for the majority of cutaneous damage and is believed to be the single most important etiologic agent in the development of non-melanoma skin cancers (NMSC). These skin tumors are by far the most common form of cancer in humans, with over 1 million new cases identified in the United States each year. Several risk factors exist, which increase the chance of a patient developing NMSC including gender, immunosuppressive status and more controversially vitamin D levels. The present review provides an overview of each of these areas.
Oberyszyn
Tatiana M
TM
Department of Pathology, The Ohio State University, 1645 Neil Avenue, 129 Hamilton Hall, Columbus, OH 43210, USA. Oberyszyn.l@osu.edu
D002280:Basal Cell Carcinoma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007165:Immunosuppression Therapy; D012737:Sex Factors; D012867:Skin / Q000378:metabolism / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects; D014807:Vitamin D / Q000378:metabolism*
D014807:Vitamin D