Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p<0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p=0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region.
Liu
Zhi-Ming
ZM
Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Province, China.
Li
Le-Qun
LQ
Peng
Min-Hao
MH
Liu
Tang-Wei
TW
Qin
Zhong
Z
Guo
Ya
Y
Xiao
Kai-Yin
KY
Ye
Xin-Ping
XP
Mo
Xin-Shao
XS
Qin
Xue
X
Li
Shan
S
Yan
Lu-Nan
LN
Shen
Han-Ming
HM
Wang
LianWen
L
Wang
Qiao
Q
Wang
Kai-bo
KB
Liang
Ren-xiang
RX
Wei
Zong-liang
ZL
Ong
Choon Nam
CN
Santella
Regina M
RM
Peng
Tao
T
D000328:Adult; D016604:Aflatoxin B1 / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012306:Risk
D015415:Biomarkers; D016604:Aflatoxin B1