title: Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.
abstract: Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.
authors.affiliation: Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. karin.ekstrom.smedby@ki.se
authors.forename: Karin
authors.initials: K
authors.lastname: Ekström Smedby
authors.forename: Claire M
authors.initials: CM
authors.lastname: Vajdic
authors.forename: Michael
authors.initials: M
authors.lastname: Falster
authors.forename: Eric A
authors.initials: EA
authors.lastname: Engels
authors.forename: Otoniel
authors.initials: O
authors.lastname: Martínez-Maza
authors.forename: Jennifer
authors.initials: J
authors.lastname: Turner
authors.forename: Henrik
authors.initials: H
authors.lastname: Hjalgrim
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Adele
authors.initials: A
authors.lastname: Seniori Costantini
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Holly
authors.forename: Eleanor
authors.initials: E
authors.lastname: Willett
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Becker
authors.forename: Silvia
authors.initials: S
authors.lastname: De Sanjosé
authors.forename: Brian C-H
authors.initials: BC
authors.lastname: Chiu
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Cocco
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadié
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Anthony
authors.initials: A
authors.lastname: Staines
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Scott
authors.initials: S
authors.lastname: Davis
authors.forename: Richard
authors.initials: R
authors.lastname: Severson
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Breen
authors.forename: Brenda
authors.initials: B
authors.lastname: Birmann
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Grulich
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000150:complications; D001172:Arthritis, Rheumatoid / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications; D019070:Cell Lineage; D003710:Demography; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008228:Lymphoma, Non-Hodgkin / Q000145:classification* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011565:Psoriasis / Q000150:complications; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000150:complications