title: Remineralization of artificial interproximal carious lesions using a fluoride mouthrinse.
abstract: OBJECTIVE
  To evaluate remineralization and fluoride uptake of demineralized enamel specimens in artificial interproximal spaces using a 250 ppm fluoride mouthrinse (100 ppm amine fluoride and 150 ppm sodium fluoride) compared to a placebo-mouthrinse.
  
  
  METHODS
  This was a two-way, double-blind, in situ study. 24 volunteers wore intraoral appliances in the lower jaw with mounted demineralized enamel specimens forming an artificial interproximal space. The volunteers rinsed their mouths for 28 days, twice a day with the respective mouthrinse and brushed their teeth at least twice a day with a fluoride-free dentifrice. The specimens were cleaned once a day to simulate the use of dental floss. For analysis methods transversal microradiography, fluoride content measurement and quantitative light-induced fluorescence were used.
  
  
  RESULTS
  Mineral gain was significantly higher after the use of the fluoride mouthrinse: 571.88 Vol.% x microm (+/- 79.33 Vol.% x microm SEM) compared to the placebo treatment 51.14 Vol.% x microm (+/- 72.14 Vol.% x microm SEM). Significantly more fluoride uptake was observed after using the fluoride mouthrinse: 3666.39 microg/cm3 (+/- 513.50 microg/cm3 SEM) than after the placebo mouthrinse: 516.95 microg/cm3 (+/- 75.83 microg/cm3 SEM). The quantitative light-induced fluorescence showed a significant remineralizing effect after the fluoride treatment: -388.47 % x mm2 (+/- 18.76% x mm2 SEM) compared to the placebo treatment -27.88% x mm2 (+/- 20.19% x mm2 SEM).
authors.affiliation: Department of Operative Dentistry and Periodontology, Dental School and Hospital, Albert-Ludwigs University Freiburg, Hugstetter Str. 49, 79095 Freiburg, Germany. markus.altenburger@uniklinik-freiburg.de
authors.forename: Markus Jörg
authors.initials: MJ
authors.lastname: Altenburger
authors.forename: Jörg Fabian
authors.initials: JF
authors.lastname: Schirrmeister
authors.forename: Karl-Thomas
authors.initials: KT
authors.lastname: Wrbas
authors.forename: Elmar
authors.initials: E
authors.lastname: Hellwig
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002417:Cattle; D003731:Dental Caries / Q000628:therapy*; D003742:Dental Devices, Home Care; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005453:Fluorescence; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008852:Microradiography; D008875:Middle Aged; D009067:Mouthwashes / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014089:Tooth Remineralization / Q000379:methods*; D014099:Toothbrushing
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D009067:Mouthwashes; D010919:Placebos; C094808:amine fluoride solution; D012969:Sodium Fluoride; D005459:Fluorides