title: The formation of argpyrimidine in glyceraldehyde-related glycation.
abstract: Three major glyceraldehyde-related advanced glycation end products (AGEs) were formed from a mixture of N(alpha)-acetyllysine, N(alpha)-acetylarginine, and glyceraldehyde. Two of the compounds were MG-H1 and GLAP, as previously reported, and the other compound was identified as N(alpha)-acetyl-N(delta)-(5-hydroxy-4,6-dimethyl-pyrimidin-2-yl)-ornithine, argpyrimidine (APN). APN is a modification product of arginine residue, but it did not form from glyceraldehyde with arginine residue. The coexistence of lysine residue was necessary to APN formation.
authors.affiliation: Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Usui
authors.forename: Mio
authors.initials: M
authors.lastname: Ohguchi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Watanabe
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Hayase
mesh_terms: D005947:Glucose / Q000737:chemistry*; D005985:Glyceraldehyde / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009952:Ornithine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011743:Pyrimidines / Q000138:chemical synthesis*; D013050:Spectrometry, Fluorescence; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011743:Pyrimidines; C107313:argpyrimidine; D005985:Glyceraldehyde; D009952:Ornithine; D005947:Glucose