Exacerbation of granular corneal dystrophy type II (Avellino corneal dystrophy) after LASEK.
To report cases of granular corneal dystrophy type II (Avellino corneal dystrophy) that were exacerbated by uncomplicated laser epithelial keratomileusis (LASEK) for myopia.



Eight patients (15 eyes) with granular corneal dystrophy type II who underwent LASEK were examined by DNA sequencing, slit-lamp microscopy, and confocal microscopy.



The number and density of the opacities increased after LASEK. Best spectacle-corrected visual acuity decreased after LASEK as the density of the opacities increased. In three patients, mitomycin C was used intraoperatively, but corneal deposits also worsened in these patients.



LASEK is contraindicated in patients with granular corneal dystrophy type II because vision may be reduced from an increase in the density of corneal opacities postoperatively.
Lee
Jae Hwan
JH
Department of Ophthalmology, Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Stulting
R Doyle
RD
Lee
Dong Ho
DH
Lee
Christopher Seungkyu
CS
Kim
Woon Cho
WC
Kim
Eung Kweon
EK
D000328:Adult; D000075202:Contraindications; D003315:Cornea / Q000503:physiopathology; D003317:Corneal Dystrophies, Hereditary / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D049008:Keratectomy, Subepithelial, Laser-Assisted / Q000009:adverse effects*; D054018:Lasers, Excimer; D008297:Male; D018613:Microscopy, Confocal; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D017422:Sequence Analysis, DNA; D014792:Visual Acuity