title: Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study.
abstract: OBJECTIVE
  To describe the epidemiology and clinical spectrum of reactive arthritis (ReA) following culture-confirmed infection with bacterial enteric pathogens in a population-based study in the USA.
  
  
  METHODS
  We conducted telephone interviews of persons age>1 year with culture confirmed Campylobacter, Escherichia coli O157, Salmonella, Shigella and Yersinia infections reported to FoodNet (http://www.cdc.gov/FoodNet/) in Minnesota, USA and Oregon, USA between 2002 and 2004.
  
  
  METHODS
  with new onset joint pain, joint swelling, back pain, heel pain and morning stiffness lasting >or=3 days within 8 weeks of culture (possible ReA) were invited to complete a detailed questionnaire and physical examination.
  
  
  RESULTS
  A total of 6379 culture-confirmed infections were reported; 70% completed screening interviews. Of these, 575 (13%) developed possible ReA; incidence was highest following Campylobacter (2.1/100,000) and Salmonella (1.4/100,000) infections. Risk was greater for females (relative risk (RR) 1.5, 95% CI, 1.3 to 1.7), adults (RR 2.5, 95% CI, 2.0 to 3.1) and subjects with severe acute illness (eg, fever, chills, headache, persistent diarrhoea). Risk was not associated with antibiotic use or human leukocyte antigen (HLA)-B27. A total of 54 (66%) of 82 subjects examined had confirmed ReA. Enthesitis was the most frequent finding; arthritis was less common. The estimated incidence of ReA following culture-confirmed Campylobacter, E coli O157, Salmonella, Shigella and Yersinia infections in Oregon was 0.6-3.1 cases/100,000.
  
  
  CONCLUSIONS
  This is the first population-based study of ReA following infections due to bacterial enteric pathogens in the USA. These data will help determine the burden of illness due to these pathogens and inform clinicians about potential sequelae of these infections.
authors.affiliation: Oregon Health and Science University, Mailcode L457, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239-3098, USA. townesj@ohsu.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Townes
authors.forename: A A
authors.initials: AA
authors.lastname: Deodhar
authors.forename: E S
authors.initials: ES
authors.lastname: Laine
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: H E
authors.initials: HE
authors.lastname: Krug
authors.forename: A
authors.initials: A
authors.lastname: Barkhuizen
authors.forename: M E
authors.initials: ME
authors.lastname: Thompson
authors.forename: P R
authors.initials: PR
authors.lastname: Cieslak
authors.forename: J
authors.initials: J
authors.lastname: Sobel
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D016918:Arthritis, Reactive / Q000453:epidemiology* / Q000382:microbiology; D002169:Campylobacter Infections / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004756:Enterobacteriaceae Infections / Q000453:epidemiology*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D009922:Oregon / Q000453:epidemiology; D010808:Physical Examination / Q000379:methods; D000091402:Prohibitins; D012480:Salmonella Infections / Q000453:epidemiology; D017678:Sex Distribution; D055815:Young Adult