title: Effectiveness of lidocaine infusion for status epilepticus in childhood: a retrospective multi-institutional study in Japan.
abstract: We evaluated the usefulness of intravenous lidocaine therapy for managing of status epilepticus (SE) during childhood in a retrospective multi-institutional study. Questionnaires were sent to 28 hospitals concerning patients admitted for SE who were managed with lidocaine, assessing patient characteristics, treatment protocols and efficacy. In 279 treated patients, 261 SE occurrences at ages between 1 month and 15 years were analyzed. SE was classified as showing continuous, clustered, or frequently repeated seizures. Considering efficacy and side effects in combination, the usefulness of lidocaine was classified into six categories: extremely useful, useful, slightly useful, not useful, associated with deterioration, or unevaluated. In 148 SE cases (56.7%), lidocaine was rated as useful or extremely useful. Multivariate analysis indicated lidocaine was to be useful in SE with clustered and frequently repeated seizures, and SE attributable to certain acute illnesses, such as convulsions with mild gastroenteritis. Efficacy was poor when SE caused by central nervous system (CNS) infectious disease. Standard doses (approximately 2mg/kg as a bolus, 2mg/kg/h as maintenance) produced better outcomes than lower or higher doses. Poor responders to the initial bolus injection of lidocaine were less likely to respond to subsequent continuous infusion than good initial responders. We recommend lidocaine for use in SE with clustered or frequently repeated seizures, and in SE associated with benign infantile convulsion and convulsions with mild gastroenteritis. Lidocaine should be initiated with a bolus of 2mg/kg. If SE is arrested by the bolus, continuous maintenance infusion should follow; treatment should proceed to different measures when SE shows a poor response to the initial bolus of lidocaine.
authors.affiliation: Department of Pediatrics, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. hattorih@med.osaka-cu.ac.jp
authors.forename: Hideji
authors.initials: H
authors.lastname: Hattori
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Yamano
authors.forename: Kitami
authors.initials: K
authors.lastname: Hayashi
authors.forename: Makiko
authors.initials: M
authors.lastname: Osawa
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kondo
authors.forename: Masao
authors.initials: M
authors.lastname: Aihara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haginoya
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hamano
authors.forename: Tatsurou
authors.initials: T
authors.lastname: Izumi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kaneko
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kato
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsukura
authors.forename: Kimio
authors.initials: K
authors.lastname: Minagawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Miura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.forename: Takao
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Yamanouchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hideto
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007564:Japan; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine