Thickening and enhancement of multiple cranial nerves in conjunction with cystic white matter lesions in early infantile Krabbe disease.
We present serial MR findings in a child ultimately diagnosed with the early infantile form of Krabbe disease. MR showed typical features of Krabbe disease including cerebellar and brainstem hyperintensity, periventricular and deep white matter hyperintensity, and cerebral atrophy. In addition, the combination of both enlargement and enhancement of multiple cranial nerves in conjunction with unusual cystic lesions adjacent to the frontal horns of the lateral ventricles was previously unreported and expands the spectrum of imaging findings in early Krabbe disease.
Beslow
Lauren A
LA
Division of Neurology, The Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd., Philadelphia, PA 19104-4399, USA. beslow@email.chop.edu
Schwartz
Erin S
ES
Bönnemann
Carsten G
CG
D000402:Airway Obstruction; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D003391:Cranial Nerves / Q000473:pathology*; D002658:Developmental Disabilities / Q000209:etiology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D005698:Galactosylceramidase / Q000097:blood; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011859:Radiography
D003287:Contrast Media; D005698:Galactosylceramidase