Enriched enrolment with randomised withdrawal (EERW): Time for a new look at clinical trial design in chronic pain.
McQuay
Henry J
HJ
Pain Research, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK Institut Gustave-Roussy, Département de Interdisciplinaire de Soins de Support, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France Laboratoires Grunenthal, 100-102 rue de Villiers, 92309 Levallois-Perret, France.
Derry
Sheena
S
Moore
Andrew R
AR
Poulain
Philippe
P
Legout
Valérie
V
D000700:Analgesics / Q000008:administration & dosage*; D002908:Chronic Disease / Q000628:therapy; D003627:Data Interpretation, Statistical; D006801:Humans; D010148:Intractable Pain / Q000188:drug therapy* / Q000503:physiopathology* / Q000523:psychology; D011897:Random Allocation; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000592:standards*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000523:psychology; D016896:Treatment Outcome; D028761:Withholding Treatment / Q000592:standards
D000700:Analgesics