title: A palladium-catalyzed alkylation/direct arylation synthesis of nitrogen-containing heterocycles.
abstract: A norbornene-mediated palladium-catalyzed sequence is described in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one reaction vessel. The aryl-heteroaryl bond-forming step occurs via a direct arylation reaction. A number of six-, seven-, and eight-membered ring-annulated indoles, pyrroles, pyrazoles, and azaindoles were synthesized from the corresponding bromoalkyl azole and an aryl iodide.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 Canada.
authors.forename: Christophe
authors.initials: C
authors.lastname: Blaszykowski
authors.forename: Evangelos
authors.initials: E
authors.lastname: Aktoudianakis
authors.forename: Dino
authors.initials: D
authors.lastname: Alberico
authors.forename: Cyril
authors.initials: C
authors.lastname: Bressy
authors.forename: David G
authors.initials: DG
authors.lastname: Hulcoop
authors.forename: Farnaz
authors.initials: F
authors.lastname: Jafarpour
authors.forename: Arash
authors.initials: A
authors.lastname: Joushaghani
authors.forename: Benoît
authors.initials: B
authors.lastname: Laleu
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D000478:Alkylation; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D010165:Palladium; D009584:Nitrogen