Implications of imaging malaria sporozoites.
The sporozoites of Plasmodium parasites undergo several transmigrations before their establishment in the hepatocytes of a vertebrate host. Techniques that illustrate parasite intra-vital migration and their interaction with host cells will advance the understanding of parasite biology. In a recent publication, Amino et al. provided a detailed protocol for in vivo imaging of Plasmodium berghei sporozoites in the dermis. The report has important implications in the dissection of malaria parasite biology.
Chen
Qijun
Q
Key Laboratory of Zoonosis, Ministry of Education, Changchun 130062, China. robm@interchange.ubc.ca [corrected]
Wang
Heng
H
D000818:Animals; D006790:Host-Parasite Interactions; D008099:Liver / Q000469:parasitology*; D008124:Locomotion; D008288:Malaria / Q000469:parasitology*; D010961:Plasmodium / Q000472:pathogenicity* / Q000502:physiology*; D034101:Sporozoites / Q000502:physiology*