title: Prediabetes: a must to recognise disease state.
abstract: Prediabetes mellitus (PDM) is defined as a state of abnormal glucose homeostasis in which deficiency or resistance to insulin is the hallmark. PDM precedes the development of overt type 2 DM. It is associated with increased mortality and morbidity and thus fits well with the criteria of a disease condition. Framing PDM as a disease and not a risk or a 'pre' stage for diabetes is needed to facilitate early management.
  
  
  OBJECTIVE
  This review aims therefore to increase awareness of PDM as a disease state.
  
  
  METHODS
  To do so, we shall preview guidelines for its diagnosis. Its prevalence and hazards will be then discussed. Finally, we shall elaborate on the current treatment guidelines.
  
  
  RESULTS
  Enough evidence support the notion that PDM is a curable disease state.
  
  
  CONCLUSIONS
  The current recommendations for the treatment of PDM should be adhered. In addition, there is a room for the use of other pharmacological agents.
authors.affiliation: Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Canada.
authors.forename: W Shehab
authors.initials: WS
authors.lastname: Eldin
authors.forename: M
authors.initials: M
authors.lastname: Emara
authors.forename: A
authors.initials: A
authors.lastname: Shoker
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D050110:Bariatric Surgery / Q000379:methods; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008019:Life Style; D017410:Practice Guidelines as Topic; D011236:Prediabetic State / Q000175:diagnosis* / Q000628:therapy; D015995:Prevalence; D012307:Risk Factors; D009626:Terminology as Topic; D015431:Weight Loss
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents