Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants.
Experiments on Wistar rats showed that subacute poisoning with anticholinesterase toxicants zarin and agent VX (daily subcutaneous injections in 1/7 LD50 for 6 days) led to suppression of cellular and humoral immune reactions and to a decrease in blood concentrations of cytokines (IL-2, IL-4, IFN-gamma) with a reduction of the IFN-gamma/IL-4 and IL-2/IL-4 ratios, which attests to more pronounced decrease in Th1 lymphocyte function in comparison with Th2 cells.
Zabrodskii
P F
PF
Saratov Military Institute of Radiation, Chemical, and Biological Protection. pz@renet.com.ru
Germanchuk
V G
VG
Mandych
V G
VG
Kadushkin
A M
AM
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D008297:Male; D062025:Organophosphate Poisoning; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012524:Sarin / Q000506:poisoning*; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*
D002800:Cholinesterase Inhibitors; D007371:Interferon-gamma; D007376:Interleukin-2; D015847:Interleukin-4; D009946:Organothiophosphorus Compounds; D012524:Sarin; C009680:VX-agent