Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations.
Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR)=1.30, 95% confidence interval (CI); 1.13-1.49, p=0.00027, allele count model] and Koreans (OR=1.19, 95% CI; 1.02-1.38, p=0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.
Hinohara
Kunihiko
K
Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.
Nakajima
Toshiaki
T
Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.|Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Takahashi
Megumi
M
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Hohda
Shigeru
S
Department of Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.
Sasaoka
Taishi
T
Department of Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.
Nakahara
Ken-Ichi
KI
Division of Internal Medicine, National Hospital Organization Nagasaki Medical Center, Ohmura, Japan.
Chida
Kouji
K
Department of Cardiology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan.
Sawabe
Motoji
M
Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan.
Arimura
Takuro
T
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Sato
Akinori
A
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Lee
Bok-Soo
BS
Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
Ban
Ji-Min
JM
Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
Yasunami
Michio
M
Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.|Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Park
Jeong-Euy
JE
Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
Izumi
Toru
T
Department of Cardiology, Kitasato University School of Medicine, Sagamihara, Japan.
Kimura
Akinori
A
Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan. akitis@mri.tmd.ac.jp.|Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. akitis@mri.tmd.ac.jp.
D044466:Asian People / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007564:Japan; D007723:Korea; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018709:Statistics, Nonparametric
D017931:DNA Primers