title: Effect of UVC radiation on conformational restructuring of human serum albumin.
abstract: The study of the influence of UVC-254 nm radiation on spectroscopic and calorimetric properties of human serum albumin in aqueous solutions was conducted. This radiation did not only accelerate aging of albumin solutions but also caused the other qualitative changes. The dose dependent effect on conformational restructuring and thermal stability of albumin for exposure periods from 10 to 60 min was shown. The differences in response to UVC-irradiation between non-defatted and fatty acid-free albumins were found.
authors.affiliation: University of Silesia, A. Chełkowski Institute of Physics, Department of Medical Physics, ul. Uniwerytecka 4, 40-007 Katowice, Poland. michnik@us.edu.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Michnik
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Michalik
authors.forename: Zofia
authors.initials: Z
authors.lastname: Drzazga
mesh_terms: D002152:Calorimetry, Differential Scanning; D005227:Fatty Acids / Q000737:chemistry; D006801:Humans; D011487:Protein Conformation / Q000528:radiation effects; D012709:Serum Albumin / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
chemical_list: D005227:Fatty Acids; D012709:Serum Albumin; D014867:Water