title: [Difficult treatment of amiodarone-induced thyrotoxicosis: a case report].
abstract: Amiodarone causes changes in thyroid function tests in about 15-20% of patients, inducing either hypothyroidism or thyrotoxicosis. The iodine load and the destructive thyroiditis caused by amiodarone produce thyrotoxicosis. We report a case of amiodarone-induced thyrotoxicosis diagnosed when investigating the reason for worsening of cardiac function. Prognosis and treatment of cardiac disorder were determined by thyrotoxicosis. The management needed a closed monitoring of thyroid function. Treatment was based on high doses of propylthiouracil and dexamethasone, but they couldn t control cardiac condition and surgery was warranted. When amiodarone-induced thyrotoxicosis is refractory to medical treatment, we believe surgery should be considered earlier.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Departamento de Medicina, Universidad de Valencia, Valencia. teresapedrofont@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Pedro
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Hervás
authors.forename: R
authors.initials: R
authors.lastname: Lorente
authors.forename: M
authors.initials: M
authors.lastname: Catalá
authors.forename: J
authors.initials: J
authors.lastname: Ortega
authors.forename: J T
authors.initials: JT
authors.lastname: Real
authors.forename: R
authors.initials: R
authors.lastname: Carmena
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000628:therapy*
chemical_list: D000638:Amiodarone