Secondary amyloidosis associated with histiocytosis X.
We report a 34-year-old man diagnosed with Langerhans cell histiocytosis (LCH) or histiocytosis X in 1980. He had multiple focal osseous lesions, difficult control of the disease activity and was treated many times with chemo- and radiotherapy for symptomatic control. His kidney disease started 20 years after the diagnosis with progressive renal failure and increasing non-nephrotic proteinuria, coinciding with two flares of LCH. A percutaneous renal biopsy demonstrated amyloidosis. There is only one case described in the amyloidosis literature associated with LCH.
Pérez-Martínez
J
J
Marques
M
M
Kilmurray
L
L
Medina
I
I
Nam-Cha
S H
SH
Llamas
F
F
Gómez
C
C
Barrientos
A
A
Blanco
J
J
D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001706:Biopsy; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D011507:Proteinuria / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D051437:Renal Insufficiency / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000628:therapy