title: The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine.
abstract: Two decades following their description, the significance of Modic vertebral endplate and marrow changes remains a matter of debate. These changes are closely related to the normal degenerative process affecting the lumbar spine, and their prevalence increases with age. However, the exact pathogenesis underlying these changes and their relation to segmental instability of the lumbar spine and to low back pain remain unclear. In this paper, we review the literature relevant to this topic and discuss the currently available evidence regarding the pathologic and clinical significance of Modic changes.
authors.affiliation: Department of Neurosurgery, Saint-Joseph University and Hôtel-Dieu de France, Beirut, Lebanon. rrahme@waln.org
authors.forename: R
authors.initials: R
authors.lastname: Rahme
authors.forename: R
authors.initials: R
authors.lastname: Moussa
mesh_terms: D001855:Bone Marrow Diseases / Q000150:complications* / Q000175:diagnosis*; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000175:diagnosis*; D007593:Joint Instability / Q000175:diagnosis* / Q000209:etiology; D017116:Low Back Pain / Q000175:diagnosis* / Q000209:etiology*; D008159:Lumbar Vertebrae / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D013117:Spinal Cord Compression / Q000175:diagnosis* / Q000209:etiology; D013131:Spine / Q000473:pathology