Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods.
OBJECTIVE
To analyse the susceptibility pattern of a collection of Fusarium clinical isolates.


METHODS
The antifungal susceptibility pattern of 67 isolates of Fusarium was analysed. Strains were identified by morphological and molecular methods by means of sequencing elongation factor alpha.


CONCLUSIONS
Six different species were identified. Fusarium solani was the most frequently isolated, followed by Fusarium oxysporum, Fusarium proliferatum and Fusarium verticilloides. Amphotericin B was the only drug with in vitro activity (range: 0.015-32 mg/L). The rest of the antifungals tested (itraconazole, voriconazole, ravuconazole, posaconazole and terbinafine) showed very poor activity against Fusarium, confirming the multiresistant nature of this genus.
Alastruey-Izquierdo
Ana
A
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.
Cuenca-Estrella
Manuel
M
Monzón
Araceli
A
Mellado
Emilia
E
Rodríguez-Tudela
Juan Luís
JL
D000935:Antifungal Agents / Q000494:pharmacology*; D004271:DNA, Fungal / Q000235:genetics; D025141:Drug Resistance, Fungal; D005670:Fusarium / Q000145:classification / Q000166:cytology / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*; D020648:Peptide Elongation Factor 1 / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA
D000935:Antifungal Agents; D004271:DNA, Fungal; D020648:Peptide Elongation Factor 1