Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries.
The parallel synthesis of gamma-turn-inspired peptidomimetic libraries has been demonstrated through two approaches toward the preparation of 1,4-diazepin-5-ones. In the first approach, 1,4-diazepin-5-ones scaffolds were prepared on gram scale and subsequently diversified to produce libraries. In a second approach, libraries of 1,4-diazepin-5-ones were produced directly through a three-component strategy that maximizes the diversity obtained in a single step.
Fenster
Erik
E
KU Chemical Methodologies and Library Development Center, University of Kansas, 1501 Wakarusa Drive, Lawrence, Kansas 66047, USA.
Rayabarapu
Dinesh K
DK
Zhang
Mianji
M
Mukherjee
Shubhasish
S
Hill
David
D
Neuenswander
Ben
B
Schoenen
Frank
F
Hanson
Paul R
PR
Aubé
Jeffrey
J
D000215:Acylation; D000478:Alkylation; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*
D001381:Azepines; D010455:Peptides