A careful disorderliness in the proteome: sites for interaction and targets for future therapies.
The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein-protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules.
Russell
Robert B
RB
EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. russell@embl.de
Gibson
Toby J
TJ
D040901:Proteomics; D013812:Therapeutics