title: Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
abstract: The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.
authors.affiliation: College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: André
authors.initials: A
authors.lastname: Alker
authors.forename: Armin
authors.initials: A
authors.lastname: Ruf
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Wang
authors.forename: Francis C K
authors.initials: FC
authors.lastname: Chiu
authors.forename: Julia
authors.initials: J
authors.lastname: Morizzi
authors.forename: Susan A
authors.initials: SA
authors.lastname: Charman
authors.forename: William N
authors.initials: WN
authors.lastname: Charman
authors.forename: Christian
authors.initials: C
authors.lastname: Scheurer
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dong
authors.forename: Daniel
authors.initials: D
authors.lastname: Hunziker
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Vennerstrom
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000378:metabolism*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry* / Q000378:metabolism*; D013141:Spiro Compounds / Q000737:chemistry* / Q000378:metabolism*
chemical_list: C503429:1,2,4-trioxane; D000962:Antimalarials; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; C528887:OZ381; C528886:OZ397; D010545:Peroxides; D013141:Spiro Compounds; C489136:arterolane; D003577:Cytochrome P-450 Enzyme System; D000218:Adamantane