Tonic and phasic pyloric activity in response to CCK-octapeptide.
BACKGROUND
The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide.


METHODS
Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 microg kg(-1) h(-1).


RESULTS
Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 +/- 2.1 to 9.9 +/- 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 microg kg(-1) h(-1) dose increased tonic pressure (8.8 +/- 1.4 to 17.6 +/- 2.0 mmHg; P = 0.01) as compared with the 0.02 microg kg(-1) h(-1) dose (4.7 +/- 0.7 to 7.3 +/- 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 +/- 28.4 mmHg and their frequency was 4.9 +/- 1.1 contractions min(-1).


CONCLUSIONS
CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 mug kg(-1) h(-1) is greater than the response to 0.02 mug kg(-1) h(-1).
Friedenberg
Frank K
FK
Department of Medicine, Section of Gastroenterology, Temple University Hospital, Temple University School of Medicine, 3401 N. Broad Street, Philadelphia, PA 19140, USA. frank.friedenberg@temple.edu
Desipio
Joshua
J
Korimilli
Annapurna
A
Bohning
Matthew
M
Sum
Eva
E
Parkman
Henry P
HP
Richter
Joel E
JE
Fisher
Robert S
RS
D000328:Adult; D002404:Catheterization; D004305:Dose-Response Relationship, Drug; D004867:Equipment Design; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008365:Manometry / Q000295:instrumentation*; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D011706:Pyloric Antrum / Q000187:drug effects* / Q000503:physiopathology; D011708:Pylorus / Q000187:drug effects* / Q000503:physiopathology; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D014159:Transducers
D012844:Sincalide