title: Eph/ephrin signaling: networks.
abstract: Bidirectional signaling has emerged as an important signature by which Ephs and ephrins control biological functions. Eph/ephrin signaling participates in a wide spectrum of developmental processes, and cross-regulation with other communication pathways lies at the heart of the complexity underlying their function in vivo. Here, we review in vitro and in vivo data describing molecular, functional, and genetic interactions between Eph/ephrin and other cell surface signaling pathways. The complexity of Eph/ephrin function is discussed in terms of the pathways that regulate Eph/ephrin signaling and also the pathways that are regulated by Eph/ephrin signaling.
authors.affiliation: Université de Toulouse, Centre de Biologie du Développement, 31062 Toulouse cedex 9, France.
authors.forename: Dina
authors.initials: D
authors.lastname: Arvanitis
authors.forename: Alice
authors.initials: A
authors.lastname: Davy
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D036342:Ephrins / Q000502:physiology*; D006801:Humans; D020239:Receptor Cross-Talk; D036081:Receptors, Eph Family / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family