title: [Our clinical experiences of amrubicin hydrochloride monotherapy in extensive-disease small cell lung cancer].
abstract: We retrospectively investigated monotherapy of amrubicin hydrochloride in patients with extensive-disease small cell lung cancer (ED-SCLC) and assessed its efficacy and safety. Twenty-two patients were enrolled. The response rate of total, previously untreated, sensitive relapsed, and refractory relapsed cases were 59%, 50%, 100% and 46%, respectively. As for the dose of amrubicin, the response rates of 30 mg/m(2), 35 mg/m(2), 40 mg/m(2), and 45 mg/m(2) were 50%, 33%, 69% and 100%, respectively. Severe myelosuppression was frequently observed as the adverse event, but significant differences among several dosages were not recognized. Median survival time was 230 days in relapsed cases. Monotherapy of amrubicin might be effective in ED-SCLC not only as first-line but also as second-line treatment in relapsed cases. The recommended dose was above 40 mg/m(2) because of its higher response rate.
authors.affiliation: Division of Pulmonary Medicine, Dept. of Medicine, Jichi Medical University.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kawakami
authors.forename: Shoji
authors.initials: S
authors.lastname: Ohno
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsujita
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hosono
authors.forename: Akira
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yamasawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Bando
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Sugiyama
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018943:Anthracyclines / Q000009:adverse effects / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018943:Anthracyclines; C055866:amrubicin