Ulcerations caused by livedoid vasculopathy associated with a prothrombotic state: Response to warfarin.
A 50-year-old woman had a lifelong history of painful ulcerations as a result of livedoid vasculopathy. She was a heterozygous carrier of factor V Leiden and prothrombin gene mutations and was receiving hormone replacement therapy. The ulcers healed after warfarin therapy, which has been reported to be effective in only one previous patient with this condition.
Davis
Mark D P
MD
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Wysokinski
Waldemar E
WE
D000925:Anticoagulants / Q000627:therapeutic use*; D005165:Factor V / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology; D054068:Livedo Reticularis / Q000473:pathology; D008875:Middle Aged; D009154:Mutation; D011516:Prothrombin / Q000235:genetics; D017445:Skin Diseases, Vascular / Q000150:complications* / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D019851:Thrombophilia / Q000150:complications / Q000235:genetics*; D014859:Warfarin / Q000627:therapeutic use*
D000925:Anticoagulants; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin