Anti-20S proteasome antibodies in psoriatic arthritis.
OBJECTIVE
Proteasomes are targets of humoral autoimmune response in patients with connective tissue diseases and other organ-specific autoimmune diseases. The finding of circulating proteasomes in psoriasis, the multiplicity of mechanisms regulated by proteasomes that are also implicated in the pathogenesis of psoriatic arthritis (PsA), and the increasing evidence linking PsA and autoimmunity led us to evaluate whether the 20S proteasome represents an antibody target in PsA.


METHODS
Serum samples from 36 patients with PsA and 30 age- and sex-matched healthy subjects were tested for the presence of anti-20S proteasome antibodies (anti-20S antibody). Additional controls included 24 patients with systemic lupus erythematosus (SLE) and 20 with rheumatoid arthritis (RA). The associations of anti-20S antibodies with clinical, laboratory, and therapeutic measures were evaluated.


RESULTS
27.8% of the PsA patients were positive for anti-20S antibody compared to 41.6% of the SLE group and 5% of the RA group. None of the healthy subjects were seropositive for anti-20S antibody. In PsA, anti-20S seropositivity was not associated with the presence of other autoantibodies or with a particular subgroup of articular involvement.


CONCLUSIONS
Immunoreactivity against proteasomes occurs frequently in patients with PsA. This finding supports the concept of PsA as an autoimmune disease and opens new avenues for investigating its pathogenesis.
Colmegna
Inés
I
Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.
Sainz
Bruno
B
Citera
Gustavo
G
Maldonado-Cocco
Jose A
JA
Garry
Robert F
RF
Espinoza
Luis R
LR
D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood* / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008297:Male; D008875:Middle Aged; D046988:Proteasome Endopeptidase Complex / Q000276:immunology*
D001323:Autoantibodies; D046988:Proteasome Endopeptidase Complex