[Frequency of the Pro 12Ala polymorphism of PPARgamma2 gene in Ukrainian population and its possible role in development of metabolic syndrome].
Frequency of the Pro 12Ala gene polymorphism PPARg2 has been studied in 39 healthy men and 42 men with metabolic syndrome (MS) of the age of 40-65 years in Ukrainian population. The frequencies were 27.9% for 12Ala allele, 32.6% for Pro12Ala, and 4.4% for Ala1Ala that is close to the results of estimation of Czech population. The frequency of 12Ala allele was significantly less--18.4% (p < 0.05) in the persons with MS that corresponds to the pre-established information concerning the patients with diabetes of the 2nd type. A tendency has been detected to the increase of the body mass index in patients with 12Ala allele in the metabolic syndrome group.
Kaĭdashev
I P
IP
Rasin
A M
AM
Shlykova
O A
OA
Gorbas'
I M
IM
Smirnova
I P
IP
Petrushov
A V
AV
Rasin
M S
MS
D000328:Adult; D000368:Aged; D000409:Alanine / Q000235:genetics; D001794:Blood Pressure; D015992:Body Mass Index; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D011392:Proline / Q000235:genetics; D014455:Ukraine / Q000453:epidemiology; D044465:White People
D047495:PPAR gamma; D004247:DNA; D011392:Proline; D000409:Alanine