title: Assignment of the absolute configuration of goniodomin A by NMR spectroscopy and synthesis of model compounds.
abstract: The complete absolute configuration of goniodomin A, an actin-targeting polyether macrolide isolated from the marine dinoflagellate Alexandrium hiranoi, was established from analysis of ROESY experiments and coupling constants, synthesis of suitable model compounds for NMR spectroscopic comparisons, degradation experiments, and correlation with synthetic reference compounds.
authors.affiliation: Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-amamiya, Aoba-ku, Sendai 981-8555, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takeda
authors.forename: Jinglu
authors.initials: J
authors.lastname: Shi
authors.forename: Masato
authors.initials: M
authors.lastname: Oikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000199:Actins / Q000187:drug effects; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry*; D004141:Dinoflagellida / Q000737:chemistry; D004987:Ethers / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000199:Actins; D000935:Antifungal Agents; D004987:Ethers; D018942:Macrolides; C059668:goniodomin A