In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis.
In the present work, we evaluated the effect of gatifloxacin on the evolution of experimental murine infection with Nocardia brasiliensis using linezolid as a control. Gatifloxacin was injected subcutaneously at 100 mg/kg body weight every 8 h for 4 weeks. This compound was equally as efficient as linezolid in reducing the production of lesions.
Daw-Garza
Alejandra
A
Servicio de Dermatología, Hospital Universitario José E González, Monterrey, NL, México.
Welsh
Oliverio
O
Said-Fernández
Salvador
S
Lozano-Garza
Hector Gerardo
HG
Waksman de Torres
Noemi
N
Rocha
Norma Cavazos
NC
Ocampo-Candiani
Jorge
J
Vera-Cabrera
Lucio
L
D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D000077734:Gatifloxacin; D006801:Humans; D000069349:Linezolid; D051379:Mice; D008807:Mice, Inbred BALB C; D009615:Nocardia / Q000145:classification / Q000187:drug effects*; D009617:Nocardia Infections / Q000188:drug therapy* / Q000382:microbiology; D023303:Oxazolidinones / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D000081:Acetamides; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D023303:Oxazolidinones; D000069349:Linezolid; D000077734:Gatifloxacin