On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles.
Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained.
Chimichi
Stefano
S
Dipartimento di Chimica Organica U. Schiff and Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi (HeteroBioLab), University of Florence, I 50019 Sesto F.no (Firenze), Italy. stefano.chimichi@unifi.it
Boccalini
Marco
M
Selleri
Silvia
S
Costagli
Camilla
C
Guerrini
Gabriella
G
Viola
Giampietro
G
D049109:Cell Proliferation / Q000187:drug effects; D004583:Electrons; D006801:Humans; D019169:Jurkat Cells; D011083:Polycyclic Compounds / Q000138:chemical synthesis; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011083:Polycyclic Compounds; D011743:Pyrimidines