Dermatopathology and molecular genetics.
The diagnosis of inherited skin diseases has been traditionally been based on clinical findings and occasionally on dermatopathology. Recent developments in molecular genetics have increased tremendously the diagnostic accuracy of genetic skin diseases, but also expanded the role of dermatopathology in the diagnosis and understanding of the pathogenesis of inherited skin diseases. The following is a review of some of the recent discoveries and how they interact with dermatopathology.
Bergman
Reuven
R
Department of Dermatology, Rambam Medical Center, Haifa, Israel. r_bergman@rambam.health.gov.il
D000505:Alopecia / Q000175:diagnosis / Q000235:genetics; D003880:Dermatology / Q000379:methods*; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D010336:Pathology / Q000379:methods*; D012873:Skin Diseases, Genetic / Q000175:diagnosis* / Q000378:metabolism; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000235:genetics
D007633:Keratins