Effect of Siraitia grosvenorii polysaccharide on glucose and lipid of diabetic rabbits induced by feeding high fat/high sucrose chow.
The Siraitia grosvenorii polysaccharide (SGP) from the Siraitia grosvenorii (Swingle) was isolated and purified. The therapeutic effects of SGP on diabetic rabbits induced by feeding high fat/high sucrose chow were studied. After administration of SGP for 4 weeks, the fasting blood glucose (FBG), plasma insulin levels (INS), plasma total cholesterol (TC), triglyceride (TG), and HDL-C were assayed. The results showed that administration of SGP can significantly decrease plasma total cholesterol, triglyceride, and glucose levels; and increase HDL-C levels after 4 weeks of treatment. The antihyperglycaemic effect of SGP at dose of 100 mg.kg(-1) bw was the most significant in three dosage groups. Furthermore, SGP could restore the blood lipid levels of diabetic rabbits (P<.05). These data indicate that SGP not only ameliorates the lipid disorder, but also lowers plasma glucose levels. So SGP have obvious glucose-lowering effect on hyperglycaemic rabbits induced by feeding high fat/high sucrose chow, its mechanism may be related to amelioration of lipid metabolism and restoring the blood lipid levels of hyperglycaemic rabbits.
Lin
Guo-Ping
GP
School of Life Science and Technology, University of South China, Hengyang 421001, Hunan, China. linguo098@yahoo.com
Jiang
Tao
T
Hu
Xiao-Bo
XB
Qiao
Xin-Hui
XH
Tuo
Qin-Hui
QH
D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D019662:Cucurbitaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000188:drug therapy*; D004041:Dietary Fats / Q000009:adverse effects*; D008055:Lipids / Q000097:blood*; D011134:Polysaccharides / Q000494:pharmacology*; D011817:Rabbits; D013395:Sucrose / Q000009:adverse effects*
D001786:Blood Glucose; D004041:Dietary Fats; D008055:Lipids; D011134:Polysaccharides; D013395:Sucrose