[Detection of primary antiretroviral resistance in Chilean patients recently infected with human immunodeficiency virus (HIV)].
BACKGROUND
In countries with universal access to antiretroviral therapy a progressive increase in the number of patients that are infected with resistant virus, is observed.


OBJECTIVE
To detect the presence of primary resistance to antiretroviral drugs among patients with a recent diagnosis of HIV infection.


METHODS
Twenty-five male patients aged 25 to 45 years, with a diagnosis of a recent HIV infection, done between 2004 and 2005, were studied. Genotypic resistance to antiretroviral drugs was studied using the Genetic Resistance Test TRUGENE from Bayer.


RESULTS
Resistance mutations were detected in 10 patients. All had an university title or had university studies. All lived in northeastern Santiago and had risky sexual behaviors while traveling abroad. Seven mutations were detected in reverse transcriptase. Of these, three were associated to a high resistance level and four, to an intermediate or low resistance, were also detected.


CONCLUSIONS
A high frequency of genotypic resistance was detected in this group of Chilean patients recently infected with HIV. A higher socioeconomic status and lifestyle could have influenced these results.
Acevedo
William
W
Sección Inmunología, Hospital Clínico, Universidad de Chile, Santiago, Chile. wacevedo@redclinicauchile.cl
Gallardo
Ana María
AM
Galaz
José
J
Afani
Alejandro
A
Cortés
Esteban
E
D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002677:Chile; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D006678:HIV / Q000187:drug effects* / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D019562:Viral Load
D019380:Anti-HIV Agents; D054303:HIV Reverse Transcriptase; D016333:HIV Protease