title: Introduction to peptide synthesis.
abstract: This overview presents a review of classical and current solid-phase peptide synthesis techniques. Peptide synthesis has become a more practical part of present-day scientific research following the advent of solid-phase techniques, and has practical commercial and scientific implications. This unit provides information on solid-phase peptide-synthesis methodology, offering descriptions of different supports, coupling reagents, and practical approaches to the synthesis of modified residues and structures. It also presents information concerning protein synthesis and the purification and analysis of synthetic peptides. This methodology has great implications for the design of synthetic peptides to serve in antibody production.
authors.affiliation: Florida Atlantic University, Boca Raton, Florida, USA.
authors.forename: Gregg B
authors.initials: GB
authors.lastname: Fields
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001372:Aza Compounds; D002625:Chemistry, Organic / Q000295:instrumentation / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D004024:Dicyclohexylcarbodiimide; D010455:Peptides / Q000138:chemical synthesis* / Q000276:immunology / Q000302:isolation & purification; D011506:Proteins / Q000138:chemical synthesis; D014230:Triazoles
chemical_list: D000596:Amino Acids; D001372:Aza Compounds; D010455:Peptides; D011506:Proteins; D014230:Triazoles; D004024:Dicyclohexylcarbodiimide; C435757:1-hydroxy-7-azabenzotriazole