title: Nasal NK/T-cell lymphoma: epidemiology and pathogenesis.
abstract: Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein-Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-KIT, revealed the different frequencies by district. Epidemiological studies revealed the changes of the disease frequency in Korea during the period from 1977-1989 to 1990-1996. Case-control study showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.
authors.affiliation: Department of Pathology (C3), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. aozasa@molpath.med.osaka-u.ac.jp.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
authors.affiliation: Department of Pathology (C3), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takakuwa
authors.affiliation: Department of Radiation Biology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hongyo
authors.affiliation: Department of Pathology, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Woo-Ick
authors.initials: WI
authors.lastname: Yang
mesh_terms: D001208:Asia / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects; D020031:Epstein-Barr Virus Infections / Q000150:complications; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology* / Q000821:virology; D007843:Latin America / Q000453:epidemiology; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D009669:Nose Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D010573:Pesticide Residues / Q000009:adverse effects; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
chemical_list: D010573:Pesticide Residues; D019009:Proto-Oncogene Proteins c-kit