Chromosomal changes induced in mouse bone marrow cells following six weeks inhalation of cyclohexanol.
The effects of low doses of cyclohexanol exposure were studied in mouse bone marrow cells including chromosome aberrations (CA), micronucleus (MN) and sister chromatid exchanges (SCE) as biomarkers. Capillaries with a tested agent that was evaporated continuously were placed in an experimental chamber for six weeks. No clastogenic and/or aneugenic effect of CA and MN induction was observed. A significant elevation of induced damage was achieved in the SCE study (p < 0.001) that has confirmed the early exposure of cyclohexanol to mice.
Siviková
Katarína
K
Institute of Genetics, University of Veterinary Medicine, Komenského 73, 041 81 Kosice, Slovak Republic. sivikova@uvm.sk
Dianovský
J
J
Piesová
Elena
E
Holecková
Beatá
B
D000280:Administration, Inhalation; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced*; D003511:Cyclohexanols / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D003511:Cyclohexanols