HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.
We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.
Mahdi
Najat
N
Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain.
Al-Ola
Khadija
K
Al-Subaie
Abeer M
AM
Ali
Muhallab E
ME
Al-Irhayim
Zaid
Z
Al-Irhayim
A Qader
AQ
Almawi
Wassim Y
WY
D000293:Adolescent; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000097:blood / Q000235:genetics* / Q000276:immunology; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000235:genetics* / Q000276:immunology; D002648:Child; D003251:Constriction, Pathologic / Q000097:blood*; D004730:Endothelium, Vascular / Q000473:pathology; D004913:Erythrocytes, Abnormal / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D007511:Ischemia / Q000097:blood*; D008297:Male
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen