title: The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP.
abstract: OBJECTIVE
  To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP).
  
  
  METHODS
  The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The contents of some inflammatory indexes in blood were determined. The rat mortality, pathological changes of heart, the changes of NF-kappaB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels as well as apoptotic index were observed in all groups, respectively, at 3 hours, 6 hours, and 12 hours after operation.
  
  
  RESULTS
  The survival rate of model group was less than treated groups at 12 hours, difference was significant. The contents of some inflammatory indexes of the treated groups were lower than those of the model group to various degrees at different time points. The pathological myocardial changes under light microscope were milder in treated groups than in model group. The changes of NF-kappaB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in all groups were different. There was only a case of myocardial cell apoptosis in an Octreotide-treated group at 6 hours.
  
  
  CONCLUSIONS
  Baicalin and Octreotide have protecting effects on heart injury of rats with SAP.
authors.affiliation: Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, Zhejiang Province , China. zxp99688@vip.163.com
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiping
authors.forename: Tian
authors.initials: T
authors.lastname: Hua
authors.forename: Chen
authors.initials: C
authors.lastname: Hanqing
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Wang
authors.initials: W
authors.lastname: Zhiwei
authors.forename: Wang
authors.initials: W
authors.lastname: Keyi
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.forename: Li
authors.initials: L
authors.lastname: Yun
authors.forename: Li
authors.initials: L
authors.lastname: Qingyu
authors.forename: He
authors.initials: H
authors.lastname: Qing
authors.forename: Wang
authors.initials: W
authors.lastname: Fei
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis; D053148:Caspase 3 / Q000096:biosynthesis; D005419:Flavonoids / Q000494:pharmacology*; D005765:Gastrointestinal Agents / Q000494:pharmacology; D006335:Heart Injuries / Q000188:drug therapy*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D015282:Octreotide / Q000494:pharmacology*; D019007:P-Selectin / Q000096:biosynthesis; D010195:Pancreatitis / Q000188:drug therapy*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D005765:Gastrointestinal Agents; D016328:NF-kappa B; D019007:P-Selectin; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; C038044:baicalin; D053148:Caspase 3; D015282:Octreotide