title: Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance.
abstract: Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylalanine-arginine-beta-naphthylamide (PAbetaN) revealed an additional system(s) contributing to intrinsic resistance. This is the first analysis of the role of multidrug efflux systems in Aeromonas spp.
authors.affiliation: CNRS UMR 5234, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France. corinne.arpin@bacterio.u-bordeaux2.fr.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Hernould
authors.forename: Séverine
authors.initials: S
authors.lastname: Gagné
authors.forename: Michel
authors.initials: M
authors.lastname: Fournier
authors.forename: Claudine
authors.initials: C
authors.lastname: Quentin
authors.forename: Corinne
authors.initials: C
authors.lastname: Arpin
mesh_terms: D016980:Aeromonas hydrophila / Q000187:drug effects* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001693:Biological Transport, Active; D004151:Dipeptides / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013379:Substrate Specificity
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004151:Dipeptides; C419365:phenylalanine arginine beta-naphthylamide