title: Complexation of morin with three kinds of cyclodextrin. A thermodynamic and reactivity study.
abstract: Properties of inclusion complexes between morin (M) and beta-cyclodextrin (betaCD), 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and Heptakis (2,6-O-di methyl) beta-cyclodextrin (DMbetaCD) such as aqueous solubility and the association constants of this complex have been determined. The water solubility of morin was increased by inclusion with cyclodextrins. The phase-solubility diagrams drawn from UV spectral measurements are of the A(L)-type. Also ORAC(FL) studies were done. An increase in the antioxidant reactivity is observed when morin form inclusion complex with the three cyclodextrin studied. Finally, thermodynamics studies of cyclodextrin complexes indicated that for DMbetaCD the inclusion is primarily enthalpy-driven process meanwhile betaCD and HPbetaCD are entropy-driven processes. This is corroborated by the different inclusion geometries obtained by 2D-NMR.
authors.affiliation: Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile. cjullian@uchile.cl
authors.forename: Carolina
authors.initials: C
authors.lastname: Jullian
authors.forename: Teresita
authors.initials: T
authors.lastname: Orosteguis
authors.forename: Fernanda
authors.initials: F
authors.lastname: Pérez-Cruz
authors.forename: Paulina
authors.initials: P
authors.lastname: Sánchez
authors.forename: Fernando
authors.initials: F
authors.lastname: Mendizabal
authors.forename: Claudio
authors.initials: C
authors.lastname: Olea-Azar
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D003505:Cyclodextrins; D004305:Dose-Response Relationship, Drug; D019277:Entropy; D005419:Flavonoids / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D012995:Solubility; D013053:Spectrophotometry / Q000379:methods; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013816:Thermodynamics; D047392:beta-Cyclodextrins / Q000737:chemistry*; D047309:Flavones
chemical_list: D000975:Antioxidants; D003505:Cyclodextrins; D005419:Flavonoids; D047392:beta-Cyclodextrins; C008548:morin; D047309:Flavones; C031215:betadex