[A cellulose derivative with a potential to become an active pharmaceutical substance as well as an auxiliary substance].
The review article is focused on one of the wide range of pharmaceutically and medicinally employed cellulose derivates--oxycellulose. This substance, prepared by oxidation of cellulose, in contrast to cellulose esters and ethers, has not been not employed in practice in a wide extent yet. However, recent studies reveal its potential use in modern therapeutical systems, whether as a release-modifying excipient, a drug carrier, or also an active substance with ability of hemostasis, prevention of tissue adhesion after surgical operations, and a substance with antimicrobial and immunomodulating activity, whose unique property of biodegradability, promoted by hypoallergenicity and non-irritability, has not been observed in any of the hitherto used cellulose derivates. The article presents a comprehensive overview about the history of this derivate, from its physico-chemical properties through the description of the ability of biodegradability to its already realized and planned utilization.
Gajdziok
J
J
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ustav technologie léků. gazi007@seznam.cz
Bajerová
M
M
Chalupová
Z
Z
Masteiková
R
R
D002626:Chemistry, Pharmaceutical; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives*; D010592:Pharmaceutic Aids
D010592:Pharmaceutic Aids; D065347:Hypromellose Derivatives; D008747:Methylcellulose