Immunopharmacological properties of noopept.
Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, noopept exhibited immunocorrector properties.
Kovalenko
L P
LP
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Shipaeva
E V
EV
Alekseeva
S V
SV
Pronin
A V
AV
Durnev
A D
AD
Gudasheva
T A
TA
Ostrovskaja
R U
RU
Seredenin
S B
SB
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000917:Antibody Formation / Q000187:drug effects; D004151:Dipeptides / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007111:Immunity, Cellular / Q000187:drug effects; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D017737:Macrophages, Peritoneal / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects; D012756:Sheep
D000893:Anti-Inflammatory Agents; D004151:Dipeptides; C103871:ethyl phenylacetyl-Pro-Gly