title: Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis).
abstract: A 12-year-old, male black and white colobus monkey (Colobus guereza kikuyuensis) from a small community zoo presented with a 6-month history of mild, slowly progressive ataxia and paresis culminating in an acute episode of recumbency, depression, and seizures. The animal was humanely euthanatized. Gross post-mortem examination revealed significant abnormalities including diffuse pallor of the carcass and a firm, pale, 8-cm diameter mass, adherent to the serosa of the proximal duodenum and colon, and embedded within the pancreas and mesenteric root. Histologically, the mass had characteristics of a neuroendocrine or endocrine tumor. Immunohistochemical stains for chromogranin, synaptophysin, insulin, and glucagon were positive, confirming the diagnosis of a mixed pancreatic islet cell tumor. These tumors are rare in all species except ferrets and unreported previously in colobus monkeys.
authors.affiliation: Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hobson
authors.forename: Patricia V
authors.initials: PV
authors.lastname: Turner
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D003104:Colobus; D003106:Colon / Q000473:pathology; D003937:Diagnosis, Differential; D004386:Duodenum / Q000473:pathology; D037901:Euthanasia, Animal; D007150:Immunohistochemistry; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*