title: Exploration of hematological and immunological changes associated with the severity of type 2 diabetes mellitus in Japan.
abstract: It has been postulated that immune modulation and activation play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM), but evidence for this has not yet been well documented. We explored the changes in peripheral immunocompetent cells in relationship to the severity of T2DM in 142 patients, and 34 healthy individuals in Japan. A severity index with 0-12 grades was derived based on the HbA1c level and the number of complications. By multiple regression analysis, the severity index was positively associated with neutrophil counts and negatively associated with platelet and CD19+ lymphocyte counts. However, we did not observe any significant changes in other lymphocyte subsets such as CD4+, CD8+, and CD56+. These results suggest that poor diabetic control may be marked by changes in some blood cell types.
authors.affiliation: Faculty of Health Sciences, Yamaguchi University School of Medicine, Yamaguchi, Japan. kozue@yamaguchi-u.ac.jp
authors.forename: Kozue
authors.initials: K
authors.lastname: Okano
authors.forename: Minako
authors.initials: M
authors.lastname: Araki
authors.forename: Misa
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Toshizo
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ichihara
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018941:Antigens, CD19; D001792:Blood Platelets; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D007121:Immunocompetence; D007564:Japan; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010865:Pilot Projects
chemical_list: D018941:Antigens, CD19; D006442:Glycated Hemoglobin