title: [Collections of pathogenic viruses for addressing general biologic problems].
abstract: Development of the theory and practice of building and maintenance of collections of reference cultures of pathogens strains is actual in conservation of a biodiversity, and as for maintenance with standardized superfine starting materials fundamental and applied researches in fields of microbiology, an immunology, biotechnology, ecology, and biosafety. Various approaches to taxonomy of viruses, and also definition of concepts "strain" and "species" are discussed in the article. Formulations of the concepts most conforming to museum collections activity are given. The methodology of collecting pathogens, including fifteen-year experience of maintenance of the National collection of hemorrhagic fever viruses belonging to group I of pathogenicity, is summarized. The systemic approach is suggested as a basis of methodology of collecting. Selection of pathogen species and their specific strains according to purpose and on the basis of complex study of their biological and other characteristics, as well as standardization and unification of methods of pathogens maintenance and preparing on their basis working materials, diagnostic kits and other preparations, create a real basis of optimization, unification and continuity of the subsequent applied researches. The offer about formation at the state level of a new independent direction--pathogens collecting with establishment of federal centers based on pathogens' classes has been made.
authors.forename: V A
authors.initials: VA
authors.lastname: Markin
mesh_terms: D000047:Academies and Institutes / Q000592:standards*; D000818:Animals; D044822:Biodiversity; D002965:Classification; D006801:Humans; D007391:International Cooperation; D009626:Terminology as Topic; D014774:Virulence; D014777:Virus Diseases / Q000821:virology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000145:classification* / Q000472:pathogenicity