Cadmium telluride quantum dots as pH-sensitive probes for tiopronin determination.
The pH-sensitive cadmium telluride (CdTe) quantum dots (QDs) were used as proton probes for tiopronin determination. Based on the fluorescence quenching of CdTe QDs caused by tiopronin, a simple, rapid and specific quantitative method was proposed. Under the optimal conditions, the calibration plot of ln(F(0)/F) with concentration of tiopronin was linear in the range of 0.15-20 microg mL(-1)(0.92-122.5 micromol L(-1)) with correlation coefficient of 0.998. The limit of detection (LOD) (3sigma/k) was 0.15 microg mL(-1)(0.92 micromol mL(-1)). The content of tiopronin in pharmaceutical tablet was determined by the proposed method and the result agreed with that obtained from the oxidation-reduction titration method and the claimed value.
Wang
Yun-Qing
YQ
Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing 210009, China.
Ye
Chao
C
Zhu
Zheng-Hui
ZH
Hu
Yu-Zhu
YZ
D019187:Cadmium Compounds / Q000737:chemistry*; D002138:Calibration; D046529:Microscopy, Electron, Transmission; D015335:Molecular Probes; D010084:Oxidation-Reduction; D045663:Quantum Dots; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013691:Tellurium / Q000737:chemistry*; D008625:Tiopronin / Q000032:analysis*
D019187:Cadmium Compounds; D015335:Molecular Probes; D008625:Tiopronin; D013691:Tellurium; C028337:cadmium telluride