title: Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug.
abstract: BACKGROUND
  Desmoid tumours or fibromatoses are rare entities characterized by the benign proliferation of fibroblasts, which can be life-threatening due to their locally aggressive properties. Surgery is widely accepted as the first line of treatment for extra-abdominal desmoids; however, it is not recommended for intra-abdominal desmoids because of the high-risk of recurrence and difficulties with the operation. Here, we report on a patient with sporadic intra-abdominal desmoid tumours, who showed partial response following the intake of non-steroidal anti-inflammatory drugs.
  
  
  METHODS
  A 73-year-old man presented with swelling and pain of the right leg. Computed tomography showed an abnormal multilocular soft-tissue mass (95 x 70 mm) in the right pelvis, which was revealed by biopsy to be a desmoid tumour. Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin, CD34, or desmin. Very few Ki-67-positive cells were found. Non-cytotoxic treatment with etodolac (200 mg/day) was chosen because of the patient's age, lack of bowel obstruction, and the likelihood of prostate cancer. Two years after the commencement of non-steroidal anti-inflammatory drug administration, computed tomography showed a decrease in tumour size (63 x 49 mm), and the disappearance of intratumoural septa.
  
  
  CONCLUSIONS
  Our case report suggests that non-steroidal anti-inflammatory drug treatment should be taken into consideration for use as first-line treatment in patients with sporadic intra-abdominal desmoid tumours.
authors.affiliation: Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. keita2s@hyo-med.ac.jp
authors.forename: Keita
authors.initials: K
authors.lastname: Tanaka
authors.forename: Reigetsu
authors.initials: R
authors.lastname: Yoshikawa
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yanagi
authors.forename: Makoto
authors.initials: M
authors.lastname: Gega
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hashimoto-Tamaoki
authors.forename: Syozo
authors.initials: S
authors.lastname: Hirota
authors.forename: Tohru
authors.initials: T
authors.lastname: Tsujimura
authors.forename: Naohiro
authors.initials: N
authors.lastname: Tomita
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy*; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D018221:Fibromatosis, Abdominal / Q000188:drug therapy*; D018222:Desmoid Tumors / Q000188:drug therapy*; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal