title: Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57.
abstract: In order to search for structurally novel and bioactive natural compounds from microorganisms, a halotolerant fungal strain, Penicillium citrinum B-57, which mainly produces citrinin derivatives, was isolated from sediments collected from the Jilantai salt field. From the ethyl acetate extract of P. citrinum B-57, two new citrinin dimers, pennicitrinone C ( 1) and penicitrinol B ( 2), and 11 known related compounds were isolated and identified by spectroscopic and chemical methods. These compounds showed antioxidative activity against DPPH radicals with IC 50 values ranging from 0.8 to 59 microM.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Lu
authors.forename: Zhen-Jian
authors.initials: ZJ
authors.lastname: Lin
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Fang
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhu
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002681:China; D002953:Citrinin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010851:Picrates / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; C529464:penicitrinol B; C529463:pennicitrinone C; D002953:Citrinin; C004931:1,1-diphenyl-2-picrylhydrazyl