Delivering silence: advancements in developing siRNA therapeutics.
The number of small interfering RNA (siRNA)-based therapeutics that are in or nearing human clinical trials is rapidly expanding. This review summarizes recent in vivo data obtained from studies on siRNA therapeutics and gives an overview of the key in vivo delivery technologies in use today. A section is also devoted to currently ongoing clinical trials employing siRNA drugs.
Novobrantseva
Tatiana I
TI
Alnylam Pharmaceuticals Inc, 300 Third Street, Cambridge, MA 02142, USA. tnovobrantseva@alnylam.com
Akinc
Akin
A
Borodovsky
Anna
A
de Fougerolles
Antonin
A
D000818:Animals; D002986:Clinical Trials as Topic; D004337:Drug Carriers; D016503:Drug Delivery Systems; D018274:Electroporation; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D011108:Polymers; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*
D004337:Drug Carriers; D008081:Liposomes; D011108:Polymers; D034741:RNA, Small Interfering