title: Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus.
abstract: To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 were DNAemia-negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.
authors.affiliation: Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. mg.revello@smatteo.pv.it
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Revello
authors.forename: Milena
authors.initials: M
authors.lastname: Furione
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zavattoni
authors.forename: Beatrice
authors.initials: B
authors.lastname: Tassis
authors.forename: Umberto
authors.initials: U
authors.lastname: Nicolini
authors.forename: Elisa
authors.initials: E
authors.lastname: Fabbri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gerna
mesh_terms: D000649:Amniocentesis / Q000009:adverse effects*; D015415:Biomarkers; D015331:Cohort Studies; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000635:transmission*; D004279:DNA, Viral / Q000097:blood*; D005188:False Negative Reactions; D005260:Female; D005865:Gestational Age; D006801:Humans; D007049:Iatrogenic Disease; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D004279:DNA, Viral