title: Application of an in vivo swine model for the determination of arsenic bioavailability in contaminated vegetables.
abstract: Considerable information is available in the literature regarding the uptake of arsenic (As) from contaminated soil and irrigation water by vegetables. However, few studies have investigated As speciation in these crops while a dearth of information is available on As bioavailability following their consumption. In this study, the concentration and speciation of As in chard, radish, lettuce and mung beans was determined following hydroponic growth of the vegetables using As-contaminated water. In addition, As bioavailability was assessed using an in vivo swine feeding assay. While As concentrations ranged from 3.0 to 84.2mg As kg(-1) (dry weight), only inorganic As (arsenite and arsenate) was detected in the edible portions of the vegetables. When As bioavailability was assessed through monitoring blood plasma As concentrations following swine consumption of As-contaminated vegetables, between 50% and 100% of the administered As dose was absorbed and entered systemic circulation. Arsenic bioavailability decreased in the order mung beans>radish>lettuce=chard.
authors.affiliation: Centre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the Environment, University of South Australia, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia. Albert.Juhasz@unisa.edu.au
authors.forename: Albert L
authors.initials: AL
authors.lastname: Juhasz
authors.forename: Euan
authors.initials: E
authors.lastname: Smith
authors.forename: John
authors.initials: J
authors.lastname: Weber
authors.forename: Matthew
authors.initials: M
authors.lastname: Rees
authors.forename: Allan
authors.initials: A
authors.lastname: Rofe
authors.forename: Tim
authors.initials: T
authors.lastname: Kuchel
authors.forename: Lloyd
authors.initials: L
authors.lastname: Sansom
authors.forename: Ravi
authors.initials: R
authors.lastname: Naidu
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001151:Arsenic / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D001682:Biological Availability; D023421:Models, Animal; D012989:Soil Pollutants / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D013552:Swine; D014675:Vegetables / Q000378:metabolism*
chemical_list: D012989:Soil Pollutants; D001151:Arsenic