Effects of carovertin on the reaction of retinal pigmented epithelium and radial glia to bright light.
Light exposure (6000 lux, 6 h) caused reactive changes in rat retinal pigmented epithelium and radial glia on day 1. Foci of lesions with virtually complete absence of the layers formed by neurosensory cells appeared on day 7. The number of destructively changed radial gliocytes in these foci was by one order of magnitude higher than in the control. Carovertin reduced destruction of pigmented epithelium and radial glia and reduced the area of lesion foci.
Logvinov
S V
SV
Department of Histology, Embryology, and Cytology, Siberian State Medical University, Tomsk. s_logvinov@mail.ru
Plotnikov
M B
MB
Varakuta
E Yu
EY
Zhdankina
A A
AA
Potapov
A V
AV
Mikhulya
E P
EP
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D044948:Flavonols / Q000494:pharmacology; D008027:Light / Q000009:adverse effects*; D008297:Male; D009457:Neuroglia / Q000187:drug effects* / Q000528:radiation effects*; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000528:radiation effects*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D019207:beta Carotene / Q000494:pharmacology*
D044948:Flavonols; D019207:beta Carotene; D011794:Quercetin; C003377:taxifolin; D001205:Ascorbic Acid