Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.
To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.
Kang
Myung-Soo
MS
Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
Soni
Vishal
V
Bronson
Roderick
R
Kieff
Elliott
E
D000818:Animals; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D008223:Lymphoma / Q000821:virology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic
D019309:Epstein-Barr Virus Nuclear Antigens; C417029:EBV-encoded nuclear antigen 1