title: Proteomics: advances in biomarker discovery.
abstract: The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number of proteomic platforms to search for discriminant biomarkers of disease in easily accessible bodily fluids including serum and urine. Several potential pitfalls for proteomic researchers were mentioned and the potential of collaborative networks between research institutions to increase the size and power of clinical studies was discussed. Overall, the meeting highlighted the exciting opportunities that proteomic techniques offer for discovering not only diagnostic but also prognostic and mechanistic markers of a number of clinically important diseases.
authors.affiliation: Section for Infection, Division of Cellular and Molecular Medicine, St George's, University of London, London SW17 0RE, UK. mcowan@sgul.ac.uk
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Cowan
authors.forename: Jaime
authors.initials: J
authors.lastname: Vera
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000235:genetics / Q000652:urine; D000818:Animals; D001168:Arthritis / Q000276:immunology / Q000378:metabolism; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000276:immunology; D001943:Breast Neoplasms / Q000532:radiotherapy; D002358:Cartilage, Articular / Q000737:chemistry; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000175:diagnosis; D004268:DNA-Binding Proteins / Q000276:immunology; D016002:Discriminant Analysis; D019075:Electrophoresis, Capillary / Q000379:methods; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D051379:Mice; D009363:Neoplasm Proteins / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000652:urine; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D011471:Prostatic Neoplasms / Q000097:blood; D040901:Proteomics / Q000379:methods*; D011836:Radiation Tolerance / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase