Mechanism of mobilization of mesenchymal stem cell under the effect of granulocyte colony-stimulating factor.
We studied the role of cell components and extracellular matrix of the microenvironment in the mechanisms of mobilization of mesenchymal bone marrow stem cells under the effect of granulocyte colony-stimulating factor in vitro and in vivo on CBA/CaLac mice. It was found that the mechanisms underlying the dissociation effect of granulocyte colony-stimulating factor do not include its direct effect on the interaction of precursor cells with fibronectin. The major role in this process is played by changes in functional state of stromal precursors and cell component of the microenvironment induced by granulocytic colony-stimulating factor and mediated by regulatory systems of the microorganism.
Zhdanov
V V
VV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Stavrova
L A
LA
Dygai
A M
AM
Goldberg
E D
ED
D000818:Animals; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology*; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells; D008297:Male; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA
D016179:Granulocyte Colony-Stimulating Factor