GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: still a controversy?
OBJECTIVE
An update on the subject of ovarian hyperstimulation syndrome (OHSS) prevention with GnRH agonist ovulation trigger.


METHODS
Review of pertinent English language studies published during the past 4 years.


RESULTS
Randomized prospective studies support the notion that agonist trigger completely eliminates OHSS. Conflicting results regarding on going pregnancy rate probably reflect different approaches to luteal phase support. Embryos obtained and frozen after agonist trigger yield good clinical outcome in subsequent thaw cycles.


CONCLUSIONS
The notion that agonist trigger can eliminate OHSS is strongly supported by randomized controlled trials. Further research is needed to assess optimal luteal support post agonist trigger.
Kol
S
S
Maccabi Health Services, Women Health Center, 10 Markoni Street, Haifa, Israel. skol@rambam.health.gov.il
Solt
I
I
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects; D009866:Oogenesis / Q000187:drug effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010062:Ovulation Induction; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic
D007987:Gonadotropin-Releasing Hormone