title: Water-soluble two-photon absorbing nitrosyl complex for light-activated therapy through nitric oxide release.
abstract: A water-soluble nitrosyl complex with large two-photon absorption was synthesized by incorporating a two-photon absorbing chromophore with tetra(ethylene glycol) units, into the Roussin's red salt. The nitrosyl complex exhibits quenched emission due to energy transfer from the two-photon chromophore to the Roussin's red salt. The nitric oxide (NO) release induced by one- or two-photon irradiation was detected by EPR spectroscopy with a chemical probe, the Fe(II)- N-(dithiocarbamoyl)- N-methyl- d-glucamine (Fe-MGD) complex. Increased one- or two-photon excited fluorescence, with a concomitant photochemical release of NO, was observed upon one- or two-photon light irradiation. With the observed light-dependent cytotoxicity against cancer cells of the water-soluble nitrosyl complex, it was demonstrated that two-photon-functionalized nitrosyl complexes can be effective NO donors for light-activated treatment.
authors.affiliation: Department of Chemistry, Institute for Lasers, Photonics, and Biophotonics, State University of New York at Buffalo, Buffalo, New York 14260, USA.
authors.forename: Qingdong
authors.initials: Q
authors.lastname: Zheng
authors.forename: Adela
authors.initials: A
authors.lastname: Bonoiu
authors.forename: Tymish Y
authors.initials: TY
authors.lastname: Ohulchanskyy
authors.forename: Guang S
authors.initials: GS
authors.lastname: He
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D058085:Iron Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry*; D017785:Photons; D010789:Phototherapy; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D058085:Iron Compounds; D020030:Nitric Oxide Donors; D014867:Water; D009569:Nitric Oxide; C106536:Roussin's red salt