[Effects of Salviae miltiorrhizae and Platycodon grandiflorum in Tianwang Buxin decoction for microcirculation of brain meninx vascullosa in rats].
OBJECTIVE
To investigat the effects of Salviae miltiorrhizae and Platycodon grandiflorum in Tianwang Buxin decoction for microcirculation of brain meninx vascullosa in rats.


METHODS
The rats were equally and randomly divided into six groups. Control, Tianwang Buxin decoction, P. grandiflorum-absenced Tianwang Buxin decoction, Radix S. miltiorrhizae, Radix S. miltiorrhizae and P. grandiflorum, P. grandiflorum. The effect on brain meninx vascullosa in rats were observed through an inverted microscope, doppler perfusion imager and blood reheology measurement meter.


RESULTS
The effect of Tianwang Buxin decoction was best among the six groups in dilatation of the diameter of arterial and venule, and velocity of blood flow. The effect of Radix Salviae miltiorrhizae was postponed and decreased when P. grandflorum was removed of from this prescription. However, it was minimal advance of blood apparent-viscosity for Tianwang Buxin decoction.


CONCLUSIONS
It is indeed that P. grandiflorum leads S. miltiorrhizae to main and collaterall channel, goes up like the boat and oar and aims to reinforce affection for the other drugs of Tianwang Buxin decoction to mprove the microcirculation of brain meninx vascullosa of rats.
Liu
Ping
P
Traditional Chinese Medicine Pharmacy of PLA General Hospital, Beijing 100853, China. Liuping0707@yahoo.com.cn
Zhou
Wen-bing
WB
Wu
Bo
B
Chang
Hong
H
D000818:Animals; D001921:Brain / Q000098:blood supply*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D031238:Platycodon / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C532371:tianwang buxinwan