title: Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea.
abstract: This study explored the potential protective role of taurine against aminoglycoside ototoxicity and the involvement of inducible nitric oxide synthase (iNOS) in the process. Guinea pigs, which received a single intravenous administration of gentamycin (100 mg/kg) followed by one large dose of furosemide (90 mg/kg, intravenously) were used as subjects. A rapid and profound hearing loss was seen in these animals 3-day posttreatment with iNOS expression upregulated in the cochlea. However, pretreatment with taurine prevented the hearing damage with decreased iNOS expression, similar to the effect of aminoguanidine, a selective inhibitor of iNOS. These findings suggest that taurine provides protection against the acute gentamycin/furosemide ototoxicity possibly by downregulating iNOS expression in the cochlea.
authors.affiliation: Department of Physiology, the Second Military Medical University, Shanghai, PR China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Liu
authors.forename: Fang-Lu
authors.initials: FL
authors.lastname: Chi
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Gao
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000201:enzymology* / Q000503:physiopathology; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects*; D004347:Drug Interactions; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005260:Female; D005665:Furosemide; D005839:Gentamicins; D006168:Guinea Pigs; D034381:Hearing Loss / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D013654:Taurine / Q000627:therapeutic use*
chemical_list: D000617:Aminoglycosides; D005839:Gentamicins; D013654:Taurine; D005665:Furosemide; D052247:Nitric Oxide Synthase Type II