Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement.
A sample labeled to be a natural herbal supplement for the enhancement of sexual function, was sent to Health Sciences Authority (HSA) of Singapore for testing. An unknown compound was detected and isolated from the product. The structure of the unknown compound was identified using LC-UV, high-resolution MS, ESI-MS/MS, IR, and NMR. The compound was characterized as a phosphodiesterase-5 (PDE-5) inhibitor, benzamidenafil. This is the first report of benzamidenafil, representing a new class of PDE-5 inhibitors, as an adulterant of a dietary supplement.
Zou
Peng
P
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Hou
Peiling
P
Oh
Sharon Sze-Yin
SS
Ge
Xiaowei
X
Bloodworth
Bosco Chen
BC
Low
Min-Yong
MY
Koh
Hwee-Ling
HL
D001549:Benzamides / Q000032:analysis / Q000737:chemistry*; D002853:Chromatography, Liquid; D019587:Dietary Supplements / Q000032:analysis*; D007172:Erectile Dysfunction / Q000178:diet therapy; D005506:Food Contamination; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000032:analysis* / Q000737:chemistry / Q000145:classification*; D012846:Singapore
D001549:Benzamides; D010726:Phosphodiesterase Inhibitors; C530319:benzamidenafil