title: [Prospects for use of iodine-free radiopaques for cholecystocholangiography].
abstract: By using the compounds tantalum and lanthanum, a new radiopaque substance (ROS) was synthesized at the Institute for Chemistry of Solids, Urals Branch of the Russian Academy of Sciences. Experiments on laboratory animals provided evidence that there was no acute or chronic toxicity of helium-based lanthanum orthotantalate. The specific radiopaque properties of the agent versus iodine- and barium-containing ROSs were studied in in vitro and in vivo experiments. The radiodiagnostic properties and locally irritant effect of the test ROS versus iodine-containing agents were evaluated in dogs at cholecystocholangiography.
authors.forename: I M
authors.initials: IM
authors.lastname: Strekalov
authors.forename: L P
authors.initials: LP
authors.lastname: Larionov
authors.forename: M G
authors.initials: MG
authors.lastname: Zuev
mesh_terms: D000818:Animals; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging*; D002758:Cholangiography / Q000379:methods*; D002765:Cholecystography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004285:Dogs; D004333:Drug Administration Routes; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003287:Contrast Media