[Functions of heat shock proteins in the system of adaptive immunity. Construction of vaccines].
One of the most important aspects of heat shock proteins (HSP) functioning, namely their role in reactions of innate and adaptive immunity, was reviewed in the article. Mechanisms of involvement of HSP in processing and presentation of antigens to T-lymphocytes were described. Principles of construction of prophylactic and therapeutic vaccines on the basis of HSP were set out. Assessment of range of indications for their use and possible risks related with inductive action of vaccines on the development of immunopathologic processes was a specially discussed topic.
Sveshnikov
P G
PG
Malaĭtsev
V V
VV
Kiselev
V I
VI
D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology; D015551:Autoimmunity; D001424:Bacterial Infections / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D001428:Bacterial Vaccines / Q000009:adverse effects; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D007110:Immunity, Active; D007113:Immunity, Innate; D013601:T-Lymphocytes / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000009:adverse effects
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D006360:Heat-Shock Proteins; D014614:Vaccines, Synthetic