Comparative study of the effects of trophoblastin and polydeoxyribonucleotide preparations on cultured skin fibroblast.
We studied the effects of trophoblastin and polydeoxyribonucleotide on the morphology and functional characteristics of fibroblasts in the culture of skin cells. Positive effects of trophoblastin and polydeoxyribonucleotide on fibroblast growth and survival during culturing were demonstrated. Trophoblastin exhibited similar effects on cells of early and late passages. Polydeoxyribonucleotide exhibited a more pronounced effect on cells of late passages, whose growth activity decreased with age. Being a multicomponent preparation, trophoblastin stimulated processes leading to positive dynamic of cell development and vital activity. Polydeoxyribonucleotide had a favorable impact on functioning of basal cell structures at the level of cell nucleus and maintained high level of cells with complete DNA set.
Pleshkanyova
O G
OG
Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency for High-Technology Medical Care, Moscow. o_akhanova@mail.ru
Dubrovina
I V
IV
Teryushkova
Zh I
ZhI
Sukhikh
G T
GT
D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D011089:Polydeoxyribonucleotides / Q000494:pharmacology*; D011257:Pregnancy Proteins / Q000494:pharmacology*; D012867:Skin / Q000166:cytology
D007370:Interferon Type I; D011089:Polydeoxyribonucleotides; D011257:Pregnancy Proteins; C020947:interferon tau