Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.
We recently reported that parthenolide and related sesquiterpene lactones are able to prevent and reverse behavioral responses in planarian worms induced by acute cocaine exposure. Previous reports indicate that when planarians are chronically exposed to microM concentrations of cocaine, they display stereotypical withdrawal-like behaviors when the cocaine is removed. Here we report that parthenolide prevents this cocaine-induced expression of planarian withdrawal-like behaviors.
Rowlands
Amanda L
AL
Department of Biology, West Chester University, West Chester, PA 19383-2112, USA.
Pagán
Oné R
OR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000009:adverse effects*; D010932:Planarians / Q000502:physiology*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000523:psychology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012717:Sesquiterpenes; C002669:parthenolide; D003042:Cocaine