Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).
There is a little information in literature about circulating asymmetric dimethylarginine (ADMA) concentrations in polycystic ovary syndrome (PCOS) and the results reported are discrepant. In this study, therefore, we aimed (1) to determine the circulating ADMA concentrations in 44 women with PCOS and 22 age- and BMI-matched healthy controls, (2) to evaluate its correlations with insulin resistance, gonadotrophins, and androgen secretion, and (3) to compare effects of metformin and ethinyl estradiol-cyproterone acetate (EE/CPA) treatments on circulating ADMA concentrations. In conclusion, our data indicate that circulating ADMA concentrations in non-obese, non-hypertensive and young women with PCOS are significantly higher than healthy controls and they improved by a 3-month course of metformin and oral contraceptive treatments.
Ozgurtas
Taner
T
Department of Biochemistry and Clinical Biochemistry, Gülhane Military Medical Academy, Ankara, Turkey.
Oktenli
Cagatay
C
Dede
Murat
M
Tapan
Serkan
S
Kenar
Levent
L
Sanisoglu
S Yavuz
SY
Yesilova
Zeki
Z
Yenen
Mufit C
MC
Erbil
M Kemal
MK
Baser
Iskender
I
D000328:Adult; D000728:Androgens / Q000378:metabolism; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000494:pharmacology*; D017373:Cyproterone Acetate / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008687:Metformin / Q000494:pharmacology*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013997:Time Factors
D000728:Androgens; D003276:Contraceptives, Oral; D006062:Gonadotropins; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C018524:N,N-dimethylarginine; D008687:Metformin; D001120:Arginine