title: Neuromuscular painful disorders: a rare side effect of voriconazole in lung transplant patients under tacrolimus.
abstract: Voriconazole is an anti-fungal agent active against Aspergillus infection that is used for prophylaxis and curative treatment in lung transplant patients. We present nine cases of painful neuromuscular disorders, an unusual and rare side effect of high-dose voriconazole in association with tacrolimus.
authors.affiliation: Département de chirurgie cardio-vasculaire, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Boussaud
authors.forename: N
authors.initials: N
authors.lastname: Daudet
authors.forename: E M
authors.initials: EM
authors.lastname: Billaud
authors.forename: A
authors.initials: A
authors.lastname: Lillo-Le Louet
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
authors.forename: C
authors.initials: C
authors.lastname: Amrein
authors.forename: M Maud
authors.initials: MM
authors.lastname: Bergé
authors.forename: R
authors.initials: R
authors.lastname: Guillemain
authors.forename: C
authors.initials: C
authors.lastname: Le Beller
mesh_terms: D000293:Adolescent; D000328:Adult; D001228:Aspergillosis / Q000188:drug therapy; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D016559:Tacrolimus