[Cardiac natriuretic peptides in patients with hypertrophic cardiomyopathy].
OBJECTIVE
To study interrelation of main clinico-hemodynamic parameters and levels of natriuretic peptides (NUP) in patients with hypertrophic cardiomyopathy (HCMP).


METHODS
We measured concentrations of N-terminal fragments of precursors of plasma brain and atrial natriuretic peptides (NT-proBNP and NT-proANP) and conducted complex echocardiographical examination in 94 patients (mean age 42.3 +/- 133.8 years) with obstructive (n=43) and nonobstructive (n=51) HCMP.


RESULTS
Content of NUP did not depend on patients age, contractile function and dimensions of the left ventricle (LV), moderate and significant correlation between content of NT-proBNP, NT-proANP and type of ventricular filling (r=0.45 and 0.46, respectively), heart failure functional class (r=0.41 and 0.44, respectively), severity of LV hypertrophy (r=0.42 and 0.34, respectively), left atrial dimension (r=0.26 and 0.35, respectively), magnitude of pressure gradient in LV outflow tract (r=0.35 and 0.26, respectively). Degree of mitral regurgitation correlated significantly only with NT -proBNP level (r=0.34). The patients who eventually died (n=6) were characterized by higher plasma content of NUP.


CONCLUSIONS
In patients with HCMP elevated plasma content of N-terminal precursors of brain and atrial natriuretic peptides are associated with severity of LV diastolic dysfunction and hypertrophy of LV as well as of hemodynamic and functional disturbances.
Safrygina
Iu V
IuV
Gabrusenko
S A
SA
Ovchinnikov
A G
AG
Masenko
V P
VP
Naumov
V G
VG
Ageev
F T
FT
Belenkov
Iu N
IuN
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D002312:Cardiomyopathy, Hypertrophic / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male
D009320:Atrial Natriuretic Factor