title: Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis.
abstract: PA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of PA-824, moxifloxacin, and pyrazinamide cured mice more rapidly than the first-line regimen of rifampin, isoniazid, and pyrazinamide. If applicable to humans, regimens containing this combination may radically shorten the treatment of multidrug-resistant tuberculosis.
authors.affiliation: Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA. enuermb@jhmi.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Nuermberger
authors.forename: Sandeep
authors.initials: S
authors.lastname: Tyagi
authors.forename: Rokeya
authors.initials: R
authors.lastname: Tasneen
authors.forename: Kathy N
authors.initials: KN
authors.lastname: Williams
authors.forename: Deepak
authors.initials: D
authors.lastname: Almeida
authors.forename: Ian
authors.initials: I
authors.lastname: Rosenthal
authors.forename: Jacques H
authors.initials: JH
authors.lastname: Grosset
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001372:Aza Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008168:Lung / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D000077266:Moxifloxacin; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D009593:Nitroimidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D011718:Pyrazinamide / Q000008:administration & dosage / Q000627:therapeutic use; D011804:Quinolines / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D009593:Nitroimidazoles; D011804:Quinolines; C410767:pretomanid; D011718:Pyrazinamide; D000077266:Moxifloxacin