title: Suppressed recombination on mouse chromosome 15 defined regions of chromosomal inversions associated with koala (koa) and hairy ears (eh) mutations.
abstract: Koala (Koa) and hairy ears (Eh) mutations of mice are associated with chromosomal inversions in the distal half of chromosome 15. Since these two mutant mice show some common phenotypic features including extra hair on pinna and craniofacial dysmorphogenesis and have similar inverted regions, we determined the inverted regions of these two chromosomal inversions to examine whether a common gene is responsible for the phenotypes of these two mutants. The inverted regions were identified as the recombination-suppressed regions by linkage analysis. The length of the recombination-suppressed regions of Koa and Eh were approximately 52 and 47 Mb, respectively, and these inverted regions were not the same. These results indicate that the phenotypes of Koa and Eh mutant mice are likely to be caused by different genes.
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Katayama
authors.forename: Aki
authors.initials: A
authors.lastname: Furuno
authors.forename: Sayaka
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Miyuki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Izumi
authors.initials: I
authors.lastname: Ojika
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shinkai
authors.forename: Kouyou
authors.initials: K
authors.lastname: Akiyama
authors.forename: Takehito
authors.initials: T
authors.lastname: Tsuji
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kunieda
mesh_terms: D000818:Animals; D007446:Chromosome Inversion / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D010641:Phenotype; D011995:Recombination, Genetic / Q000235:genetics*