Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns.
The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.
Sugawa
Fumihiro
F
Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.
Wada
Yuka
Y
Maruyama
Tetsuo
T
Uchida
Hiroshi
H
Ishizuka
Bunpei
B
Ogata
Tsutomu
T
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D010641:Phenotype; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D012307:Risk Factors; D018911:Trinucleotide Repeats; D049951:X Chromosome Inactivation; D055815:Young Adult
C410798:AR protein, human; D043373:Follicle Stimulating Hormone, Human; D011944:Receptors, Androgen; D004958:Estradiol; D007986:Luteinizing Hormone