title: Expression of basement membrane laminin in oral squamous cell carcinomas.
abstract: The basement membrane is a dynamic structure that undergoes quantitative and qualitative changes during the progression of squamous cell carcinoma, which is essentially important in tumoral invasion and metastasis.
  
  
  OBJECTIVE
  This study is aimed at investigating the behavior of the basement membrane in oral squamous cell carcinomas with different malignancy scores, which were obtained through the immunohistochemical expression of the laminin, a glycoprotein present in the basement membrane.
  
  
  METHODS
  History cross-sectional cohort.
  
  
  METHODS
  Thirty-one cases of oral squamous cell carcinoma were subjected to histological grading of malignant tumors. The immunohistochemical expression of the laminin in lesions bearing different scores of malignancy was evaluated according to intensity and integrity, using the Streptavidin-Biotin complex method.
  
  
  RESULTS
  We noticed significant differences in the media between intensity and continuity laminin expression in relation to different grades of malignancy.
  
  
  CONCLUSIONS
  Different expressions of laminin, a glycoprotein present in basement membranes were evident in oral cell carcinomas within different grades of histological malignancy.
authors.affiliation: Doctorate in Dentistry, Adjunct Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University. Electronic address: srareis@uol.com.br.
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: de Almeida Reis
authors.affiliation: Master's degree in Dentistry, Substitute Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University.
authors.forename: Leonardo Francisco
authors.initials: LF
authors.lastname: Provedel de Souza
authors.affiliation: Master's degree in Dentistry, Assistant Professor, Dentistry School of the Southwestern Bahia State University.
authors.forename: Verônica
authors.initials: V
authors.lastname: Ferreira de Souza
authors.affiliation: Bolsista do Programa de Educação Tutorial, Graduanda da Faculdade de Odontologia da Universidade Federal da Bahia.
authors.forename: Lílian Dantas
authors.initials: LD
authors.lastname: de Góes Silva
authors.affiliation: Doctorate in Dentistry, Adjunct Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University.
authors.forename: Jean Nunes
authors.initials: JN
authors.lastname: Dos Santos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor; D007797:Laminin