title: Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow.
abstract: The drug-eluting stent's increasingly frequent occurrence late stage thrombosis have created a need for new strategies for intervention in coronary artery disease. This paper demonstrates further development of our minimally invasive, targeted drug delivery system that uses induced magnetism to administer repeatable and patient specific dosages of therapeutic agents to specific sites in the human body. Our first aim is the use of magnetizable stents for the prevention and treatment of coronary restenosis; however, future applications include the targeting of tumors, vascular defects, and other localized pathologies. Future doses can be administered to the same site by intravenous injection. This implant-based drug delivery system functions by placement of a weakly magnetizable stent or implant at precise locations in the cardiovascular system, followed by the delivery of magnetically susceptible drug carriers. The stents are capable of applying high local magnetic field gradients within the body, while only exposing the body to a modest external field. The local gradients created within the blood vessel create the forces needed to attract and hold drug-containing magnetic nanoparticles at the implant site. Once these particles are captured, they are capable of delivering therapeutic agents such as antineoplastics, radioactivity, or biological cells.
authors.affiliation: Department of Surgery, Drextel University College of Medicine, Philadelphia, PA 19102, USA. zachary.forbes@drextelmed.edu
authors.forename: Zachary G
authors.initials: ZG
authors.lastname: Forbes
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Yellen
authors.forename: Derek S
authors.initials: DS
authors.lastname: Halverson
authors.forename: Gregory
authors.initials: G
authors.lastname: Fridman
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Barbee
authors.forename: Gary
authors.initials: G
authors.lastname: Friedman
mesh_terms: D000818:Animals; D004343:Drug Implants; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008280:Magnetics / Q000627:therapeutic use*; D051381:Rats; D012212:Rheology / Q000295:instrumentation* / Q000379:methods; D015607:Stents
chemical_list: D004343:Drug Implants