[Brief review about compatibility and their pharmacological effects of Chinese material medica as tranquilizer].
The paper summarized the sedative pharmacological effects of CMM, which were reported in the past 10 years. Those sedative CMMs were found in several type of Chinese medicine, such as tranquilizing the mind, calming the liver to stop the wind, general tonic, blood-activating and stasis-resolving drugs, heat-clearing drugs, exterior-releasing drugs, drugs for resuscitation, diuresis-inducing and dampness-draining drugs, ect. Out of them, the general tonic drugs were used in many occasions. Two Chinese herbs, jujube seed and polygala were used popularly as sedative drugs. And their effects have something to do with heart Meridian and liver Meridian. The Locomotor activity, sleeping test and forcing swimming were used commonly to detect the sedative effects. The sedative mechanisms of those CMM were related with neuro-transmitters such as Dopamine (DA), 5-HT and gamma-GABA, etc.
Wang
Qiong
Q
Chinese Academy of Medical Sciences, Peking Union Medical College, Institute of Medicinal Plant Development, Beijing 100094, China.
Wang
Li-wei
LW
Liu
Xin-min
XM
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology / Q000627:therapeutic use; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use; D008516:Medicine, Chinese Traditional; D018377:Neurotransmitter Agents / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000378:metabolism; D014149:Tranquilizing Agents / Q000494:pharmacology / Q000627:therapeutic use*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D008419:Materia Medica; D018377:Neurotransmitter Agents; D014149:Tranquilizing Agents