title: Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries.
abstract: The parallel synthesis of gamma-turn-inspired peptidomimetic libraries has been demonstrated through two approaches toward the preparation of 1,4-diazepin-5-ones. In the first approach, 1,4-diazepin-5-ones scaffolds were prepared on gram scale and subsequently diversified to produce libraries. In a second approach, libraries of 1,4-diazepin-5-ones were produced directly through a three-component strategy that maximizes the diversity obtained in a single step.
authors.affiliation: KU Chemical Methodologies and Library Development Center, University of Kansas, 1501 Wakarusa Drive, Lawrence, Kansas 66047, USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Fenster
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Rayabarapu
authors.forename: Mianji
authors.initials: M
authors.lastname: Zhang
authors.forename: Shubhasish
authors.initials: S
authors.lastname: Mukherjee
authors.forename: David
authors.initials: D
authors.lastname: Hill
authors.forename: Ben
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Frank
authors.initials: F
authors.lastname: Schoenen
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Aubé
mesh_terms: D000215:Acylation; D000478:Alkylation; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*
chemical_list: D001381:Azepines; D010455:Peptides