title: Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10.
abstract: Intensive physical exercise may cause muscular injury and increase oxidative stress. The purpose of this study was to examine the effect of an antioxidant, coenzyme Q10 (CoQ10), on muscular injury and oxidative stress during exercise training. Eighteen male students, all elite Japanese kendo athletes, were randomly assigned to either a CoQ10 group (n 10) or a placebo group (n 8) in a double-blind manner. Subjects in the CoQ10 group took 300 mg CoQ10 per d for 20 d, while subjects in the placebo group took the same dosage of a placebo. All subjects practised kendo 5.5 h per d for 6 d during the experimental period. Blood samples were taken 2 weeks before, during (1 d, 3 d, 5 d) and 1 week after the training. Serum creatine kinase (CK) activity and myoglobin (Mb) concentration significantly increased in both groups (at 3 d and 5 d). Serum CK (at 3 d), Mb (at 3 d) and lipid peroxide (at 3 d and 5 d) of the CoQ10 group were lower than those of the placebo group. The leucocyte counts in the placebo group significantly increased (at 3 d) and neutrophils significantly increased in both groups (at 3 d and 5 d). Serum scavenging activity against superoxide anion did not change in either group. These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes.
authors.affiliation: Graduate School of Comprehensive Human Sciences, Doctoral program of Sports Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Kon
authors.forename: Kai
authors.initials: K
authors.lastname: Tanabe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Akimoto
authors.forename: Fuminori
authors.initials: F
authors.lastname: Kimura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tanimura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kono
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D006801:Humans; D007958:Leukocyte Count; D015227:Lipid Peroxidation; D008297:Male; D016139:Martial Arts / Q000293:injuries*; D018482:Muscle, Skeletal / Q000293:injuries*; D009211:Myoglobin / Q000032:analysis; D009504:Neutrophils / Q000276:immunology; D018384:Oxidative Stress; D010807:Physical Endurance; D013481:Superoxides / Q000097:blood; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009211:Myoglobin; D013481:Superoxides; D014451:Ubiquinone; D003402:Creatine Kinase; C024989:coenzyme Q10