[Preparation of chitosan-encapsulated porous calcium polyphosphate bioceramic].
OBJECTIVE
To investigate the preparation of a chitosan-encapsulated porus calcium polyphosphate (CPP) bioceramic so as to provide a feasible approach to repair of the bone defect.


METHODS
The chitosan microspheres were produced by chemical procedures. The CPP bioceramic was made by the following steps: annealing, ball milling, admixing, and calcinating. The chemical method was used to encapsule the calcinated bioceramic by the porus chitosan film. The physicochemical property, biomechanical property, and toxicity of the chitosan-encapsulated porus CPP bioceramic were analyzed.


RESULTS
The uniform holes were observed in the CPP bioceramic under a microscope. The diameter of the hole was 100-300 microm. The chitosan microballoons were amber in color. The particles were uniform with a diameter of 200-400 microm, with a poor compressive strength. They could be easily ground by hand. The maximally tolerated dose of the CPP bioceramic leaching liquor given to the Jimpy mice of both sexes was >24 g/kg on average. The compressive strength reached 200 MPa, and the interval porosity was about 60%-80%, which could completely meet with the compressive strength of the bone substitute.


CONCLUSIONS
The chitosan-encapsulated porous CPP bioceramic can be used as a good porous bioceramic scaffold material, which has a good biomechanical property with no acute toxicity, and so may be used as an excellent material for the bone substitute.
Fan
Changchun
C
Department of Traumatic Orthopedics, the Second Military Medical University Jinan school of Medicine, Jinan Shandong, 250031, PR China. fanchangchun688@sina.com
Liu
Dejun
D
Ren
Yunpeng
Y
D000818:Animals; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D048271:Chitosan / Q000737:chemistry*; D019245:Compressive Strength; D005260:Female; D008297:Male; D051379:Mice; D008863:Microspheres; D010316:Particle Size; D011122:Polyphosphates; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D023382:Toxicity Tests, Acute
D018786:Bone Substitutes; D002130:Calcium Phosphates; D011122:Polyphosphates; D048271:Chitosan