title: Association study between interleukin 1 beta gene and epileptic disorders: a HuGe review and meta-analysis.
abstract: Previous studies have examined the association of a single nucleotide polymorphism at the promoter region of interleukin 1B (IL-1 beta-511T) with temporal lobe epilepsy and febrile seizures susceptibility, but those studies have been inconclusive. Published studies up to March 2007 of temporal lobe epilepsy, febrile seizures and the IL-1 beta-511T single nucleotide polymorphism were identified by searches of Medline and Embase databases. Meta-analysis of temporal lobe epilepsy and febrile seizures case-control data were performed to assess the association of IL-1 beta-511T with temporal lobe epilepsy, temporal lobe epilepsy with hippocampal sclerosis, febrile seizures, and other epileptic disorders. Pooled odds ratios (OR) were estimated by means of a genetic-model-free approach. The quality of the included studies was assessed by a score. The results show a modest association (OR, 1.48; 95% confidence interval, 1.09-2.00; P = 0.01) between the IL-1 beta-511T polymorphism and temporal lobe epilepsy with hippocampal sclerosis.
authors.affiliation: Consultorio de Neurogenética, Centro de Epilepsia, División Neurología, Hospital Ramos Mejía, CEFYBO, CONICET, Buenos Aires, Argentina. marcelokauffman@gmail.com
authors.forename: Marcelo Andrés
authors.initials: MA
authors.lastname: Kauffman
authors.forename: Dolores Gonzalez
authors.initials: DG
authors.lastname: Moron
authors.forename: Damian
authors.initials: D
authors.lastname: Consalvo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bello
authors.forename: Silvia
authors.initials: S
authors.lastname: Kochen
mesh_terms: D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta