Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice.
The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.
Bergmeier
Wolfgang
W
Cardeza Foundation and Department of Medicine, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19007, USA. wolfgang.bergmeier@jefferson.edu
Chauhan
Anil K
AK
Wagner
Denisa D
DD
D000071120:ADAMTS13 Protein; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D004195:Disease Models, Animal; D008666:Metalloendopeptidases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010973:Platelet Adhesiveness / Q000235:genetics; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood* / Q000235:genetics; D020246:Venous Thrombosis / Q000097:blood; D014841:von Willebrand Factor / Q000235:genetics / Q000378:metabolism*
D019038:Platelet Glycoprotein GPIb-IX Complex; D014841:von Willebrand Factor; C502939:ADAMTS13 protein, mouse; D008666:Metalloendopeptidases; D000071120:ADAMTS13 Protein