Expression of basement membrane laminin in oral squamous cell carcinomas.
The basement membrane is a dynamic structure that undergoes quantitative and qualitative changes during the progression of squamous cell carcinoma, which is essentially important in tumoral invasion and metastasis.


OBJECTIVE
This study is aimed at investigating the behavior of the basement membrane in oral squamous cell carcinomas with different malignancy scores, which were obtained through the immunohistochemical expression of the laminin, a glycoprotein present in the basement membrane.


METHODS
History cross-sectional cohort.


METHODS
Thirty-one cases of oral squamous cell carcinoma were subjected to histological grading of malignant tumors. The immunohistochemical expression of the laminin in lesions bearing different scores of malignancy was evaluated according to intensity and integrity, using the Streptavidin-Biotin complex method.


RESULTS
We noticed significant differences in the media between intensity and continuity laminin expression in relation to different grades of malignancy.


CONCLUSIONS
Different expressions of laminin, a glycoprotein present in basement membranes were evident in oral cell carcinomas within different grades of histological malignancy.
de Almeida Reis
Silvia Regina
SR
Doctorate in Dentistry, Adjunct Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University. Electronic address: srareis@uol.com.br.
Provedel de Souza
Leonardo Francisco
LF
Master's degree in Dentistry, Substitute Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University.
Ferreira de Souza
Verônica
V
Master's degree in Dentistry, Assistant Professor, Dentistry School of the Southwestern Bahia State University.
de Góes Silva
Lílian Dantas
LD
Bolsista do Programa de Educação Tutorial, Graduanda da Faculdade de Odontologia da Universidade Federal da Bahia.
Dos Santos
Jean Nunes
JN
Doctorate in Dentistry, Adjunct Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D009367:Neoplasm Staging
D014408:Biomarkers, Tumor; D007797:Laminin