Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine.
OBJECTIVE
To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines.


METHODS
Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus injection of 4 mg/kg of either agent for intoxication. Hemodynamic results were then evaluated at 1, 5, 10, 15, 20 and 30 minutes.


RESULTS
Levobupivacaine had greater hemodynamic repercussions than racemic bupivacaine. These results disagree with those found when the levorotatory isomer of bupivacaine was used in humans, but are in agreement with recently reported findings in animals.


CONCLUSIONS
Levobupivacaine was shown to be more toxic in pigs than racemic bupivacaine when large doses are injected intravenously.
Udelsmann
Artur
A
Laboratory of Experimental Anesthesia, Center for Experimental Medicine and Surgery, School of Medicine, UNICAMP, Campinas, São Paulo, Brazil. audelsmann@yahoo.com.br
Lorena
Sílvia Elaine Rodolfo de Sá
SE
Girioli
Samira Ubaid
SU
Silva
William Adalberto
WA
Moraes
Ana Cristina de
AC
Andreollo
Nelson Adami
NA
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D002045:Bupivacaine / Q000031:analogs & derivatives / Q000633:toxicity*; D002319:Cardiovascular System / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D000077554:Levobupivacaine; D008297:Male; D011897:Random Allocation; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
D000779:Anesthetics, Local; D000077554:Levobupivacaine; D002045:Bupivacaine