Calciotropic and magnesiotropic TRP channels.
Significant progress has been made into our understanding of the molecular mechanisms responsible for Ca2+ and Mg2+ homeostasis. Members of the transient receptor potential channel (TRP) superfamily proved essential to the maintenance of divalent cation levels by regulating their absorption from renal and intestinal lumina. This review highlights the molecular and functional aspects of these new calciotropic and magnesiotropic TRPs in health and disease.
Hoenderop
Joost G J
JG
Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Bindels
René J M
RJ
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism; D006801:Humans; D006996:Hypocalcemia / Q000378:metabolism; D015640:Ion Channel Gating; D007674:Kidney Diseases / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D050053:TRPM Cation Channels / Q000378:metabolism; D050916:TRPV Cation Channels / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D015220:Calcium Channels; D006728:Hormones; D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; D050916:TRPV Cation Channels; D050051:Transient Receptor Potential Channels; C492240:Trpv5 protein, mouse; C446923:Trpv6 protein, mouse; D008274:Magnesium; D002118:Calcium