The effect of chronic diazepam administration on lipid peroxidation and Ca2+ -ATPase activity in rat liver.
Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca2+ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca2+ -ATPase activity may play a role in DZP induced hepatic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxicity.
Seçkin
Sule
S
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093 Istanbul, Turkey. sseckin@istanbul.edu.tr
Alsancak
Seyda
S
Başaran-Küçükgergin
Canan
C
Uysal
Müjdat
M
D000704:Analysis of Variance; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D003975:Diazepam / Q000009:adverse effects*; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D012643:Selenium / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D008315:Malondialdehyde; D000252:Calcium-Transporting ATPases; D005978:Glutathione; D012643:Selenium; D003975:Diazepam