[Role of apoptosis in the kidney after reperfusion].
Organ transplantation is one of the most important achievements of medicine in the 20th century. Ischaemia-reperfusion has a great impact on both: immediate organ function and long-term survival. Organ transplantation can be regarded as a clinical model of ischaemia-reperfusion phenomenon.


OBJECTIVE
The prevention of ischaemia-reperfusion damages. Apoptosis plays a key-role in these processes.


METHODS
Apoptosis was investigated in the course of human kidney transplantation. In animal experiments the characteristics of apoptosis were analysed after short ischaemia. Calcium antagonists: verapamil, nifedipine, bepridil, fendiline and (-)-deprenyl, an irreversible selective inhibitor of monoamino oxidase type B, (-)-deprenyl, were administered to prevent apoptosis.


RESULTS
The observations showed that in the course of human kidney transplantation necrotic, apoptotic and proliferating renal tubular cells can be observed. All calcium channel blockers and (-)-deprenyl decreased the occurrence and degree of apoptosis in rat kidney.


CONCLUSIONS
The functional capacity of tubular cells is a significant factor in the adequate kidney function. The reduction of the apoptosis of tubular cells possibly could improve the function of transplanted kidneys.
Toronyi
Eva
E
Semmelweis Egyetem, Altalános Orvostudományi Kar Transzplantációs és Sebészeti Klinika Budapest Baross u. 23. 1082. toronyi@trans.sote.hu
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015764:Bepridil / Q000008:administration & dosage; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005275:Fendiline / Q000008:administration & dosage; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D007684:Kidney Tubules / Q000473:pathology* / Q000503:physiopathology*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage; D009543:Nifedipine / Q000008:administration & dosage; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control*; D012642:Selegiline / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage
D002121:Calcium Channel Blockers; D008996:Monoamine Oxidase Inhibitors; D014665:Vasodilator Agents; D012642:Selegiline; D015764:Bepridil; D014700:Verapamil; D009543:Nifedipine; D005275:Fendiline