title: Botanicals for age-related diseases: from field to practice.
abstract: The Purdue-University of Alabama Botanicals Research Center for Age Related Disease joins novel technologies to study the bioavailability of bioactive polyphenolic constituents and their relation to health. Many diseases that manifest with age relate to oxidative stress and tissue damage. Our goal is to follow the fate of bioactive constituents from a complex mixture to the organ affected by the disease and relate that to a protective mechanism. Equally important is to screen commercially available botanicals for their efficacy and safety. Botanicals and their relation to bone antiresorptive capacity, cognitive function, vascular effects, and cancer are principal themes in our center.
authors.affiliation: Foods and Nutrition, Rutgers University, New Brunswick, NJ, USA. weavercm@purdue.edu
authors.forename: Connie M
authors.initials: CM
authors.lastname: Weaver
authors.forename: Stephen
authors.initials: S
authors.lastname: Barnes
authors.forename: J Michael
authors.initials: JM
authors.lastname: Wyss
authors.forename: Helen
authors.initials: H
authors.lastname: Kim
authors.forename: Dorothy M
authors.initials: DM
authors.lastname: Morré
authors.forename: D James
authors.initials: DJ
authors.lastname: Morré
authors.forename: James E
authors.initials: JE
authors.lastname: Simon
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Lila
authors.forename: Elsa M
authors.initials: EM
authors.lastname: Janle
authors.forename: Mario G
authors.initials: MG
authors.lastname: Ferruzzi
mesh_terms: D000375:Aging / Q000378:metabolism / Q000523:psychology; D000975:Antioxidants / Q000494:pharmacology; D001682:Biological Availability; D001808:Blood Vessels / Q000187:drug effects*; D001862:Bone Resorption / Q000188:drug therapy*; D002392:Catechin / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000517:prevention & control; D005419:Flavonoids / Q000494:pharmacology*; D006262:Health; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D018384:Oxidative Stress; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D002392:Catechin