title: Spontaneous short-term variations of circulating endothelin-1 in pulmonary hypertension.
abstract: Endothelin-1 (ET-1) is overexpressed in pulmonary arteries of pulmonary hypertension (PH) patients and contributes to the sustained vasoconstriction, remodeling process, and thrombosis of vessels that underlie development and progression of this disease. Increased circulating ET-1 correlates with markers of PH severity, and ET-1 is regarded as a potential diagnostic and prognostic biomarker in PH. Because the within-individual variability measured in PH patients and in healthy subjects contributes to determine the biomarker predictive value and must be taken into account to establish cutoff values, we determined the short-term variability of circulating ET-1 in controls and in PH patients.
authors.forename: Anne
authors.initials: A
authors.lastname: Charloux
authors.forename: Ari
authors.initials: A
authors.lastname: Chaouat
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Brandenberger
authors.forename: François
authors.initials: F
authors.lastname: Piquard
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Weitzenblum
authors.forename: Bernard
authors.initials: B
authors.lastname: Geny
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery; D012016:Reference Values; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D015415:Biomarkers; D019332:Endothelin-1