title: [Methods to evaluate aspirin and clopidogrel resistance].
abstract: Based on the concept that the so-called resistance to anti-platelet drugs is meant to describe a phenomenon where the drug does not hit its direct pharmacodynamic target, assays, used to evaluated the effects of anti-platelet drugs, should as closely as possible measure the direct pharmacodynamic effect of a particular drug. Thus, for the detection of aspirin effects, thromboxane concentrations or arachidonic acid-induced responses (light aggregometry, whole-blood aggregometry) should be measured. For the detection of clopidogrel actions, VASP phosphorylation (flow cytometry) or ADP-induced responses (light aggregometry, whole blood aggregometry) should be analysed.
authors.affiliation: Institut für Pharmakologie, Universität Duisburg-Essen, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany. artur.weber@uk-essen.de
authors.forename: A-A
authors.initials: AA
authors.lastname: Weber
authors.forename: M
authors.initials: M
authors.lastname: Adamzik
authors.forename: H S
authors.initials: HS
authors.lastname: Bachmann
authors.forename: K
authors.initials: K
authors.lastname: Görlinger
authors.forename: M
authors.initials: M
authors.lastname: Grandoch
authors.forename: K
authors.initials: K
authors.lastname: Leineweber
authors.forename: H
authors.initials: H
authors.lastname: Müller-Beissenhirtz
authors.forename: F
authors.initials: F
authors.lastname: Wenzel
authors.forename: C
authors.initials: C
authors.lastname: Naber
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D000077144:Clopidogrel; D004351:Drug Resistance; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin