HIV subtypes induce distinct profiles of HIV-specific CD8(+) T cell responses.
CD8(+) T cells play an important role in controlling HIV infection and qualitative differences in HIV-specific CD8(+) responses may determine the degree of immune control. We studied 56 HIV-infected, ARV-naive Ugandans and examined the role of subtypes in modulating their HIV-specific T cell responses. Gag-specific responses were readily detectable in our study population. Interestingly, we found significantly decreased Gag-specific cytolysis (as measured by CD107 expression) in subtype D (n = 21) compared to subtype A (n = 35) HIV infection. Sequence analyses within identified epitopes suggest patterns of conservation that are subtype specific. We conclude that HIV subtypes may promote distinct profiles of T cells responses and immune control.
Baker
Chris A R
CA
California Department of Public Health, Richmond, California 94804, USA.
McEvers
Kimberly
K
Byaruhanga
Rose
R
Mulindwa
Rwabaingi
R
Atwine
Diana
D
Nantiba
Josephine
J
Jones
Norman G
NG
Ssewanyana
Isaac
I
Cao
Huyen
H
D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D005260:Female; D005838:Genotype; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D052118:Lysosomal-Associated Membrane Protein 1 / Q000032:analysis; D052119:Lysosomal-Associated Membrane Protein 2 / Q000032:analysis; D008297:Male; D014454:Uganda; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D052118:Lysosomal-Associated Membrane Protein 1; D052119:Lysosomal-Associated Membrane Protein 2; D054301:gag Gene Products, Human Immunodeficiency Virus; D007371:Interferon-gamma