Regioselective C-H functionalization directed by a removable carboxyl group: palladium-catalyzed vinylation at the unusual position of indole and related heteroaromatic rings.
The palladium-catalyzed oxidative vinylation of indole-3-carboxylic acids with alkenes effectively proceeds via directed C-H functionalization and decarboxylation to produce the corresponding 2-vinylated indoles. Similarly, pyrrole-, furan-, and thiophenecarboxylic acids also undergo decarboxylative vinylation.
Maehara
Atsushi
A
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Tsurugi
Hayato
H
Satoh
Tetsuya
T
Miura
Masahiro
M
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D006571:Heterocyclic Compounds; D007211:Indoles; D010165:Palladium