title: Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation.
abstract: The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel-Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b-i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.
authors.affiliation: University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Robin H
authors.initials: RH
authors.lastname: Scott
authors.forename: Colin
authors.initials: C
authors.lastname: Barnes
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gerhard
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian