Arterial ischemic stroke: experience in Chinese children.
The aim of this study was to review cases of pediatric arterial ischemic stroke among Chinese subjects and thereby evaluate risk factors, clinical and neuroimaging features, and treatment, to establish a reasonable guideline for assessment and management of the disease. Between 1996 and 2006, 157 children (male:female ratio, 1.4:1) with arterial ischemic stroke were identified at Beijing Children's Hospital. The median age at stroke was 32 months (range, 4-192). Among patients with determined etiology, infections (12.1%), moyamoya disease (12.1%), and trauma (10.8%) were the most common. In 51 patients, there were no obvious risk factors (32.5%). Hemiplegia was the most common presenting feature (81.5%). The region of left middle cerebral artery was most frequently affected (36.3%), followed by the right middle cerebral artery (29.9%). Of the 157 patients, 56 were treated by intravenous thrombolytic agents (35.7%), all but one of them successfully (the one exception involving hemorrhagic complication). Randomized controlled trials are needed to establish primary prevention, acute treatment, and secondary prevention of pediatric ischemic stroke.
Shi
Kai-Li
KL
Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, China.
Wang
Jian-Jun
JJ
Li
Jiu-Wei
JW
Jiang
Li-Qiong
LQ
Mix
Eilhard
E
Fang
Fang
F
Wu
Hu-Sheng
HS
Jin
Xiao
X
Jing
Hong
H
Zou
Li-Ping
LP
D000293:Adolescent; D044466:Asian People; D002545:Brain Ischemia / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology; D010372:Pediatrics; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology / Q000209:etiology*; D015912:Thrombolytic Therapy / Q000379:methods