Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis.
Three new 3,4- seco-lanostanes, kadsuracoccinic acids A-C ( 1- 3), were isolated from the medicinal plant Kadsura coccinea, in addition to the known compounds kadsuric acid ( 4) and micranoic acid A ( 5). The structures of 1- 3 were elucidated by analysis of their 2D-NMR spectroscopic data. Furthermore, the relative conformation of 1 was confirmed by an X-ray crystallographic study. This is the first report of a 3,4- seco-lanostane-type triterpene with a 17(20)-ene functional group. Treatment of cultured individual Xenopus laevis cells with 1 at the blastular stage arrested cleavage of these cells with an IC 50 of 0.32 microg/mL.
Li
Heran
H
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
Wang
Liyan
L
Miyata
Syohei
S
Kitanaka
Susumu
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032135:Kadsura / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014982:Xenopus laevis / Q000196:embryology*
D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C529405:kadsuracoccinic acid A; C529406:kadsuracoccinic acid B; C529407:kadsuracoccinic acid C; D007810:Lanosterol