Management of pregnancy complicated by anti-hrB/anti-HrB.
Anti-hrB and anti-HrB are rare alloantibodies found predominantly in people of Black African descent. It has been assumed that strongly reacting examples of anti-hrB may cause hemolytic transfusion reactions, but precise information is limited. Anti-HrB is a clinically significant antibody and may cause hemolytic transfusion reactions and HDN. Selection of blood for transfusion support for patients with these alloantibodies, and especially with anti-HrB, imposes a special challenge in the United Kingdom. We report two antenatal patients (both patients were of the partial D phenotype DIII), one with anti-hrB, anti-Ce, and anti-D; the other,with anti-hrB and anti-D, who later formed anti-HrB. Transfusion support and the outcome of the pregnancies are discussed. A literature search confirms that,apart from some publications in abstract form,there is not much detailed clinical information available for either anti-hrB or anti-HrB. Further information and publications are warranted to gain more knowledge of these rare antibodies.
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Red Cell Immunohaematology, National Blood Service-Tooting Centre, London SW17 ORB, UK.
Needs
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Tillyer
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D000328:Adult; D001788:Blood Grouping and Crossmatching; D001803:Blood Transfusion / Q000379:methods*; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000628:therapy*; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods / Q000592:standards; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin / Q000627:therapeutic use
D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin