Platelet glycoprotein Ibalpha gene polymorphism and massive or submassive pulmonary embolism.
OBJECTIVE
The -5T/C polymorphism in the Kozak sequence of glycoprotein Ibalpha, a component of the platelet glycoprotein Ib-IX-V receptor complex, is associated with an increase in this receptor density on the surface of the platelet. This study was designed to investigate the effect of platelet glycoprotein Ibalpha Kozak polymorphism on the clinical presentation of the patients with acute pulmonary embolism.


METHODS
Forty-two patients with pulmonary embolism were genotyped for Kozak polymorphism of the glycoprotein Ibalpha by polymerase chain reaction/restriction fragment length polymorphism.


RESULTS
Carriers of the -5T/C polymorphism of glycoprotein Ibalpha were significantly over-represented in the patient group with clinically massive or submassive pulmonary embolism (odds ratio 5.5, 95% confidence interval 1.4 to 22.2, P = 0.023). Also the association between this polymorphism and massive or submassive pulmonary embolism still existed even after being adjusted for conventional risk factors.


CONCLUSIONS
The -5T/C polymorphism in the Kozak sequence of glycoprotein Ibalpha may present as a risk factor for clinical manifestation of pulmonary embolism in which clot burden plays an important role.
Soylu
Ahmet
A
Department of Cardiology, Meram Medical School of Selcuk University, S.U. Meram Tip Fakültesi Kardiyoloji AD, Konya, Turkey. asoylu44@gmail.com
Tokaç
Mehmet
M
Cora
Tülin
T
Düzenli
Mehmet Akif
MA
Acar
Hasan
H
D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011655:Pulmonary Embolism / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
D019038:Platelet Glycoprotein GPIb-IX Complex; C023592:glycocalicin