title: Oxidative stress parameters in patients with slow coronary flow.
abstract: BACKGROUND
  We investigated the probable role of free-radical damage in the pathogenesis of slow coronary flow (SCF) by using oxidative stress parameters.
  
  
  METHODS
  Sixty-four patients with angiographically proven SCF and 63 patients with normal coronary flow (NCF) pattern with similar risk profiles were enrolled in this study. We measured erythrocyte superoxide dismutase (SOD), reduced glutathione (GSH), serum malondialdehyde (MDA), catalase and myeloperoxidase (MPO) levels in all subjects.
  
  
  RESULTS
  There were statistically significant differences in the levels of erythrocyte SOD, GSH and serum MDA between the 2 groups. Serum MDA (P = 0.003) and erythrocyte SOD levels (P = 0.0001) were increased in the SCF group. The level of erythrocyte GSH (P = 0.010) was lower in patients with SCF. There were no differences between the groups' serum catalase (P = 0.682) and MPO levels (P = 0.070).
  
  
  CONCLUSIONS
  Our data showed that in patients with SCF, serum MDA and erythrocyte SOD levels were increased while erythrocyte GSH levels were decreased significantly, compared with NCF patients. These results indicate that free-radical damage may play a role in the pathogenesis of SCF.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey. enli21@yahoo.com
authors.forename: Yasar
authors.initials: Y
authors.lastname: Enli
authors.forename: Mehmet
authors.initials: M
authors.lastname: Turk
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akbay
authors.forename: Harun
authors.initials: H
authors.lastname: Evrengul
authors.forename: Halil
authors.initials: H
authors.lastname: Tanriverdi
authors.forename: Omur
authors.initials: O
authors.lastname: Kuru
authors.forename: Deniz
authors.initials: D
authors.lastname: Seleci
authors.forename: Asuman
authors.initials: A
authors.lastname: Kaftan
authors.forename: Oztekin
authors.initials: O
authors.lastname: Ozer
authors.forename: Havane
authors.initials: H
authors.lastname: Enli
mesh_terms: D001783:Blood Flow Velocity; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress