title: Structural characterization of trimethylsilyl methyl glycosides derivatives by high-resolution mass spectrometry, linked scans and MIKE experiments.
abstract: Gas chromatography-mass spectrometry investigations have been carried out for the structural analysis of trimethylsilyl methyl derivatives of keto-deoxy sugars and sialic acids studied under electron ionization. Fragmentation patterns were determined. The three derivatives undergo some common fragmentation pathways. Formation of fragment ions possessing cyclic resonance-stabilized structures was demonstrated. As the sialic acid derivative contained a N-acetyl substituent, some additional fragmentations occurred and were also elucidated. Thus, the mechanism of fragmentation was revealed for these derivatives and new findings concerning some series of fragment ions are presented.
authors.affiliation: COBRA-IRCOF, UFR des Sciences, Université de Rouen, CNRS UMR 6014, 76821, Mont-Saint-Aignan Cedex, France. corinne.loutelier@univ-rouen.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Loutelier-Bourhis
authors.forename: Muriel
authors.initials: M
authors.lastname: Bardor
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Lange
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006027:Glycosides / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012794:Sialic Acids / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000032:analysis*
chemical_list: D002241:Carbohydrates; D006027:Glycosides; D012794:Sialic Acids; D014297:Trimethylsilyl Compounds