Isoxazoles from 1,1-Disubstituted Bromoalkenes.
The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,5-disubstituted bromoisoxazoline intermediates that aromatize to the analogous isoxazoles through the loss of HBr.
Dadiboyena
Sureshbabu
S
Department of Chemistry, Jackson State University, Jackson, Mississippi 39217, USA.
Xu
Jianping
J
Hamme
Ashton T
AT