title: Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome.
abstract: To asses the role of virus load in the pathogenesis of hemorrhagic fever with renal syndrome, the serum Dobrava virus RNA load in 46 patients was measured with a novel quantitative real-time reverse-transcriptase polymerase chain reaction assay and compared to the disease severity. The level of viremia, detected in 26 patients, ranged from 10(2)-10(8) copies/mL of serum. The patients with severe disease had, on average, higher viral RNA loads than patients with a milder course of disease (6.15 vs. 4.67 log(10) copies/mL; P = .053). These results suggest that the Dobrava virus load might be associated with the severity of disease.
authors.affiliation: Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Ana
authors.initials: A
authors.lastname: Saksida
authors.forename: Darja
authors.initials: D
authors.lastname: Duh
authors.forename: Misa
authors.initials: M
authors.lastname: Korva
authors.forename: Tatjana
authors.initials: T
authors.lastname: Avsic-Zupanc
mesh_terms: D015331:Cohort Studies; D018450:Disease Progression; D006476:Orthohantavirus / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load; D014766:Viremia / Q000503:physiopathology*
chemical_list: D012367:RNA, Viral