title: Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.
abstract: A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A).
authors.affiliation: Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
authors.forename: T
authors.initials: T
authors.lastname: Hari Babu
authors.forename: V
authors.initials: V
authors.lastname: Rama Subba Rao
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: P V
authors.initials: PV
authors.lastname: Srinivas
authors.forename: Amtul Z
authors.initials: AZ
authors.lastname: Ali
authors.forename: J
authors.initials: J
authors.lastname: Madhusudana Rao
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one