[Effect of a fixed combination of perindopril and indapamide on 24-hour blood pressure profile, morpho-functional parameters of the heart, heart rate variability, functional state of the kidney, and quality of life in patients with arterial hypertension combined with metabolic syndrome].
Therapy with the use of a fixed combination of perindopril and indapamide was prescribed to 22 patients with metabolic syndrome and I - II degree hypertension for 16 weeks. Examination at baseline and after treatment included 24-hour blood pressure (BP) monitoring, echocardiography, biochemical analysis of blood, study of functional state of the kidney, heart rate variability, and quality of life. Positive dynamics of 24-hour BP profile and renal function was revealed after treatment. The therapy affected positively geometry of the left ventricle and vegetative homeostasis, improved quality of life, lowered atherogeneity of blood plasma and did not change significantly level of fasting glycemia, i.e. was associated with high antihypertensive effect and exerted pronounced organoprotective action.
Statsenko
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Zemlianskaia
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D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D007190:Indapamide / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D020913:Perindopril / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D007190:Indapamide; D020913:Perindopril