[Level of hormones of pituitary-gonadal axis, penile blood flow and sexual function in men with arterial hypertension during monotherapy with bisoprolol and nebivolol].
Measurement of levels of hormones of the pituitary-gonadal system, dopplerography of penile arteries and questioning after Vasiltchenko were carried out in 30 men (age 35-55 years) with I-II degree arterial hypertension who received monotherapy with bisoprolol and nebivolol for 2 months. Treatment with both superselective beta-adrenoblockers was associated with significant lowering of systolic and diastolic blood pressure and heart rate. Antihypertensive effect of bisoprolol was significantly more pronounced than that of nebivolol. Bisoprolol and nebivolol significantly increased concentration of testosterone (by 82 and 85%, respectively) and prolactin (by 77 and 83%, respectively), lowered levels of estradiol and follicle-stimulating hormone, improved vascular blood flow in penile arteries, and did not worsen sexual function.
Nurmamedova
G S
GS
Gumbatov
N B
NB
Mustafaev
I I
II
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D001578:Benzopyrans / Q000627:therapeutic use*; D017298:Bisoprolol / Q000627:therapeutic use*; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000627:therapeutic use*; D005500:Follow-Up Studies; D042341:Gonadal Hormones / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D009569:Nitric Oxide; D010413:Penis / Q000098:blood supply* / Q000000981:diagnostic imaging; D019529:Sexuality / Q000187:drug effects / Q000502:physiology*; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D042341:Gonadal Hormones; D000068577:Nebivolol; D009569:Nitric Oxide; D017298:Bisoprolol