Sindbis virus infection in resident birds, migratory birds, and humans, Finland.
Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe. To gain a better understanding of SINV epidemiology in Finland, we searched for SINV antibodies in 621 resident grouse, whose population declines have coincided with human SINV outbreaks, and in 836 migratory birds. We used hemagglutination-inhibition and neutralization tests for the bird samples and enzyme immunoassays and hemagglutination-inhibition for the human samples. SINV antibodies were first found in 3 birds (red-backed shrike, robin, song thrush) during their spring migration to northern Europe. Of the grouse, 27.4% were seropositive in 2003 (1 year after a human outbreak), but only 1.4% were seropositive in 2004. Among 2,529 persons, the age-standardized seroprevalence (1999-2003) was 5.2%; seroprevalence and incidence (1995-2003) were highest in North Karelia (eastern Finland). Grouse may contribute to the epidemiology of SINV in humans.
Kurkela
Satu
S
Department of Virology, Faculty of Medicine, Haartman Institute at the University of Helsinki, Haartmaninkatu 3, Helsinki, Finland. satu.kurkela@helsinki.fi
Rätti
Osmo
O
Huhtamo
Eili
E
Uzcátegui
Nathalie Y
NY
Nuorti
J Pekka
JP
Laakkonen
Juha
J
Manni
Tytti
T
Helle
Pekka
P
Vaheri
Antti
A
Vapalahti
Olli
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018354:Alphavirus Infections / Q000453:epidemiology / Q000662:veterinary*; D025041:Animal Migration; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D005387:Finland / Q000453:epidemiology; D046094:Galliformes / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D012845:Sindbis Virus / Q000472:pathogenicity*; D020308:Songbirds / Q000821:virology*; D015047:Zoonoses / Q000453:epidemiology / Q000821:virology