Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
Ermann
Monika
M
Evotec (UK) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United Kingdom. monika.ermann@evotec.com
Riether
Doris
D
Walker
Edward R
ER
Mushi
Innocent F
IF
Jenkins
James E
JE
Noya-Marino
Beatriz
B
Brewer
Mark L
ML
Taylor
Malcolm G
MG
Amouzegh
Patricia
P
East
Stephen P
SP
Dymock
Brian W
BW
Gemkow
Mark J
MJ
Kahrs
Andreas F
AF
Ebneth
Andreas
A
Löbbe
Sabine
S
O'Shea
Kathy
K
Shih
Daw-Tsun
DT
Thomson
David
D
D015394:Molecular Structure; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists*; D013329:Structure-Activity Relationship
D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2