title: Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.
abstract: We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum-infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability. The follow-up of such patients should be strengthened.
authors.affiliation: Hôpital Avicenne, Bobigny, France. remy.durand@avc.aphp.fr
authors.forename: Rémy
authors.initials: R
authors.lastname: Durand
authors.forename: Virginie
authors.initials: V
authors.lastname: Prendki
authors.forename: Johann
authors.initials: J
authors.lastname: Cailhol
authors.forename: Véronique
authors.initials: V
authors.lastname: Hubert
authors.forename: Pascal
authors.initials: P
authors.lastname: Ralaimazava
authors.forename: Laurent
authors.initials: L
authors.lastname: Massias
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouchaud
authors.forename: Jacques
authors.initials: J
authors.lastname: Le Bras
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D053626:Atovaquone / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000008:administration & dosage / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D002727:Proguanil; D053626:Atovaquone