title: Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway.
abstract: A method for the determination of five selective serotonin reuptake inhibitors (citalopram, sertraline, fluoxetine, fluvoxamine and paroxetine) and four of their metabolites (desmethylcitalopram, didesmethylcitalopram, norfluoxetine and desmethylsertraline) in seawater and sewage influents and effluents, has been developed and validated. The method is based on a three-phase hollow-fibre supported liquid phase microextraction of 1.1L samples, followed by high performance liquid chromatography with electrospray ionization and mass spectrometric detection. The detection limits varied between 17 pg/L (citalopram) and 618 ng/L (desmethylsertraline), and the quantification limits between 57 pg/L (citalopram) and 4.1 ng/L (desmethylsertraline). Sampling was done from February to August in 2007 on three different locations with dissimilarities concerning waste water treatment procedures. No significant difference in SSRI cleansing efficiency between merely sieving (Langnes STP, Tromsø) and a more advanced sewage treatment (VEAS STP, Oslo) was seen. All the investigated compounds are present in all waste water samples from these STPs, and a total concentration of SSRIs and metabolites up to 840 ng/L has been found. Untreated sewage samples have been collected in the small town Longyearbyen at Spitsbergen. Despite few inhabitants (2000), it was still possible to find traces of SSRIs in the waste water. In Tromsø and Longyearbyen the waste water is discharged into the sea, therefore seawater samples have been collected close to the outlets. The results show higher concentrations of SSRIs outside Longyearbyen than Tromsø, possibly due to the stronger tidal currents around Tromsø. However, the concentrations are quite low, not exceeding total concentrations of 3 ng/L.
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Tromsø, Tromsø, Norway. terjev@farmasi.uit.no
authors.forename: Terje
authors.initials: T
authors.lastname: Vasskog
authors.forename: Trude
authors.initials: T
authors.lastname: Anderssen
authors.forename: Stig
authors.initials: S
authors.lastname: Pedersen-Bjergaard
authors.forename: Roland
authors.initials: R
authors.lastname: Kallenborn
authors.forename: Einar
authors.initials: E
authors.lastname: Jensen
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D009664:Norway; D012680:Sensitivity and Specificity; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D012722:Sewage / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013538:Svalbard; D014867:Water / Q000032:analysis*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D012722:Sewage; D014867:Water