title: Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria.
abstract: Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention trials and cautiously suggests clinical investigation of potential preexposure prophylaxis of malaria.
authors.affiliation: Walter Reed Project, United States Army Medical Research Unit, Kisumu, Kenya. mpolhemus@wrp-ksm.org
authors.forename: Mark E
authors.initials: ME
authors.lastname: Polhemus
authors.forename: Shon
authors.initials: S
authors.lastname: Remich
authors.forename: Bernhards
authors.initials: B
authors.lastname: Ogutu
authors.forename: John
authors.initials: J
authors.lastname: Waitumbi
authors.forename: Marc
authors.initials: M
authors.lastname: Lievens
authors.forename: W Ripley
authors.initials: WR
authors.lastname: Ballou
authors.forename: D Gray
authors.initials: DG
authors.lastname: Heppner
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D053626:Atovaquone / Q000627:therapeutic use*; D018890:Chemoprevention; D006801:Humans; D053208:Kaplan-Meier Estimate; D007630:Kenya; D017780:Malaria Vaccines / Q000008:administration & dosage; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control; D018512:Parasitemia / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects / Q000276:immunology; D002727:Proguanil / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000962:Antimalarials; D017780:Malaria Vaccines; D002727:Proguanil; D053626:Atovaquone