title: Super-sentinel chickens and detection of low-pathogenicity influenza virus.
abstract: Chicken interferon-alpha administered perorally in drinking water acts on the oropharyngeal mucosal system as an adjuvant that causes chickens to rapidly seroconvert after natural infection by low-pathogenicity Influenza virus. These chickens, termed super sentinels, can serve as sensitive early detectors of clinically inapparent infections.
authors.affiliation: Department of Molecular and Cell Biology, University of Connecticut, U-3125, 75 North Eagleville Rd, Storrs, CT 06269, USA. philip.marcus@uconn.edu
authors.forename: Philip I
authors.initials: PI
authors.lastname: Marcus
authors.forename: Theodore
authors.initials: T
authors.lastname: Girshick
authors.forename: Louis
authors.initials: L
authors.lastname: van der Heide
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Sekellick
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000284:Administration, Oral; D000818:Animals; D002645:Chickens / Q000276:immunology / Q000821:virology*; D016867:Immunocompromised Host; D053126:Influenza A Virus, H7N7 Subtype / Q000276:immunology*; D005585:Influenza in Birds / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D007370:Interferon Type I / Q000008:administration & dosage; D011994:Recombinant Proteins; D018571:Sentinel Surveillance / Q000662:veterinary*; D016036:Seroepidemiologic Studies
chemical_list: D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D011994:Recombinant Proteins