Ratios of free to total prostate-specific antigen and total prostate specific antigen to protein concentrations in saliva and serum of healthy men.
BACKGROUND
We evaluated the ratio of free to total prostate-specific antigen (PSA) and PSA to protein concentrations in saliva and serum of healthy men.


METHODS
Concentrations of protein, free PSA, and total PSA in serum and saliva were measured in 30 healthy men aged 42 to 73 years, and their ratios were compared between the two fluids.


RESULTS
There was a significant direct correlation between serum free-total PSA ratios of serum and saliva (P = .04) and between total PSA-protein ratios of serum and saliva (P = .02). Also, there were significant correlations between total and free PSA levels in saliva (P = .05) and between those in serum (P < .001). Significant inverse and direct correlations were detected between the body mass index and serum values of total PSA-protein (P = .04) and free-total PSA (P = .01), respectively.


CONCLUSIONS
We can use saliva sample instead of serum sample for estimation of free-total PSA and total PSA-protein levels in men without prostate diseases. There is, however, a pressing need for much additional research in this area before the true clinical value of saliva as a diagnostic fluid can be determined.
Ayatollahi
Hossein
H
Department of Biochemistry and Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. ayatollahih@mums.ac.ir
Darabi Mahboub
Mohammad Reza
MR
Mohammadian
Nema
N
Parizadeh
Mohammad Reza
MR
Kianoosh
Tayyebeh
T
Khabbaz Khoob
Mahdi
M
Kamalian
Fahimeh
F
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis* / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis; D012016:Reference Values; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D012471:Salivary Proteins and Peptides; D017430:Prostate-Specific Antigen