The effects of bicarbonate and its combination with chelating agents used for the removal of depleted uranium in rats.
The effects of bicarbonate and its combination with the chelating agents, deferiprone (L1), 4,6-dimethyl-1-hydroxypyrimidin-2(1H)-one (AK-4), catechol-3,6-bis(methyleneimino-diacetic-acid) (CBMIDA), and ethane-1-hydroxy-1,1-bisphoshonate (EHBP) in removing depleted uranium (DU) for radiation emergency medicine were examined. After the intramuscular injection of DU in rats, various time schedules of bicarbonate and chelating agent administration were tested. The results indicate that the bicarbonate helps increase significantly the effects of LI and AK-4, while there were no effects of using bicarbonate alone. The effects of bicarbonate on CBMIDA were unclear, and the effects of EHBP were negative. Further studies are necessary to obtain distinctly synergic effects by the combination of chelating agents with bicarbonate.
Fukuda
Satoshi
S
Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan. s_fukuda@nirs.go.jp
Ikeda
Mizuyo
M
Nakamura
Mariko
M
Katoh
Akira
A
Yan
Xueming
X
Xie
Yuyuan
Y
Kontoghiorghes
George J
GJ
D000410:Alanine Transaminase / Q000097:blood / Q000652:urine; D000469:Alkaline Phosphatase / Q000097:blood / Q000652:urine; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000652:urine; D001639:Bicarbonates / Q000378:metabolism / Q000627:therapeutic use*; D002614:Chelating Agents / Q000378:metabolism / Q000627:therapeutic use*; D015913:Chelation Therapy; D003404:Creatinine / Q000097:blood / Q000652:urine; D008297:Male; D009584:Nitrogen / Q000097:blood / Q000652:urine; D011832:Radiation Injuries / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000378:metabolism / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014501:Uranium / Q000378:metabolism*
D001639:Bicarbonates; D002614:Chelating Agents; D011837:Radiation-Protective Agents; D014501:Uranium; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D009584:Nitrogen