title: TAE226 inhibits human neuroblastoma cell survival.
abstract: OBJECTIVE
  Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro.
  
  
  METHODS
  Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated.
  
  
  RESULTS
  Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis.
  
  
  CONCLUSIONS
  Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.
authors.affiliation: Department of Surgery, University of Florida, Gainesville, Florida 32610-0286, USA. beierea@surgery.ufl.edu
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Beierle
authors.forename: Angelica
authors.initials: A
authors.lastname: Trujillo
authors.forename: Abhilasha
authors.initials: A
authors.lastname: Nagaram
authors.forename: Vita M
authors.initials: VM
authors.lastname: Golubovskaya
authors.forename: William G
authors.initials: WG
authors.lastname: Cance
authors.forename: Elena V
authors.initials: EV
authors.lastname: Kurenova
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D051417:Focal Adhesion Kinase 1 / Q000037:antagonists & inhibitors*; D006801:Humans; D009025:Morpholines / Q000494:pharmacology*; D009447:Neuroblastoma / Q000188:drug therapy* / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D009025:Morpholines; C524632:TAE226; D051417:Focal Adhesion Kinase 1