title: [To study the effect of oral mucosa cell transfected with IFN-gamma recover denuded hard palate to the growth of maxilla].
abstract: OBJECTIVE
  To study the effect of oral mucosa cell transfected with IFN-gamma recover denuded hard palate to the growth of maxilla in rats.
  
  
  METHODS
  Divide 3-week-age 80 female rats with left denuded hard palate into 4 groups randomly, depends on different methods recovered the denuded hard palate, granulation tissue growing itselves (I), transplanting amnion (II), transplanting oral mucous cell loaded by amnion (III), or oral mucous cell transfected with IFN-gamma (IV), 20 rats in one group. After 9 weeks, measure the width of left hard palate and the right, and analyse the width of hard palate by different methods.
  
  
  RESULTS
  The antisymmetry rate of hard palate width of groups I, II, III and IV are (68.64 +/- 9.03)%, (58.53 +/- 7.40)%, (53.12 +/- 4.92)% and (52.25 +/- 4.61)%, statistical analysis through SNK of SPSS 11.0 show group I is different from groups II, III, IV (P < 0.05), group II is different from groups III, IV (P < 0.05), but group III is not different from group IV (P > 0.05).
  
  
  CONCLUSIONS
  It has energetic significance to prevent maxillary secondary deformity with amnion and tissue-engineered oral mucosa recover denuded hard palate, the tissue-engineered oral mucosa is better than amnion, the tissue-engineered oral mucosa transfected with IFN-gamma is better than not transfected.
authors.affiliation: Department of Oral Maxillofacial Surgery of Zunyi Medical College, Zunyi 563003, China.
authors.forename: Qing-gao
authors.initials: QG
authors.lastname: Song
authors.forename: Bing
authors.initials: B
authors.lastname: Shi
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D002972:Cleft Palate / Q000601:surgery*; D005260:Female; D007371:Interferon-gamma / Q000235:genetics*; D008437:Maxilla / Q000002:abnormalities / Q000601:surgery; D008445:Maxillofacial Development; D009061:Mouth Mucosa / Q000637:transplantation*; D019647:Oral Surgical Procedures; D021362:Palate, Hard / Q000254:growth & development; D051381:Rats; D017207:Rats, Sprague-Dawley; D013234:Stem Cells / Q000166:cytology; D013524:Surgical Flaps; D023822:Tissue Engineering; D014162:Transfection
chemical_list: D007371:Interferon-gamma