title: Influence of atropine therapy on fenthion-induced pancreatitis.
abstract: OBJECTIVE
  We searched the influence of dose and timing of atropine therapy in fenthion-induced pancreatitis model.
  
  
  METHODS
  All rats were intoxicated with fenthion except the control group. Two milligrams of atropine was administered for 24 hours in a high dose atropine group while a low dose atropine group received 100 micrograms of atropine for 24 hours. One group received 2 milligrams of atropine in the first four hours of intoxication while the other group received 2 milligrams of atropine in the last four hours before sacrifice. All rats were sacrificed 24 hours after intoxication. Pseudo-cholinesterase and lipase concentrations and histopathological markers of pancreatitis were studied.
  
  
  RESULTS
  None of the models in this study completely prevented pancreatitis, however high dose atropine that is administered for 24 hours or the first four hours after intoxication prevented severe pancreatitis.
  
  
  CONCLUSIONS
  Atropine administration influence on fenthion-induced pancreatitis should be studied for other organophosphates in animals and humans.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Ela
authors.forename: Huseyin
authors.initials: H
authors.lastname: Fidan
authors.forename: Onder
authors.initials: O
authors.lastname: Sahin
authors.forename: Aynur
authors.initials: A
authors.lastname: Kilbas
authors.forename: Orhan
authors.initials: O
authors.lastname: Bas
authors.forename: Yucel
authors.initials: Y
authors.lastname: Yavuz
authors.forename: Hudaverdi
authors.initials: H
authors.lastname: Kucuker
authors.forename: Irfan
authors.initials: I
authors.lastname: Altuntas
mesh_terms: D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use*; D002091:Butyrylcholinesterase / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005284:Fenthion / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008049:Lipase / Q000032:analysis; D010755:Organophosphates / Q000008:administration & dosage / Q000633:toxicity; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D010755:Organophosphates; D001285:Atropine; D005284:Fenthion; D008049:Lipase; D002091:Butyrylcholinesterase