Waldenström's macroglobulinemia and large B-cell central nervous system lymphoma: a case report.
BACKGROUND
Waldenström's macroglobulinemia is a low-grade B-cell lymphoma characterized by monoclonal synthesis and secretion of IgM antibodies [3]. The classic symptoms of WM result from blood hyperviscosity. Neurologic symptoms, such as fatigue, dizziness, and blurred vision, are common. The metastatic spread to the CNS, which rarely has been reported, can occur either diffusely or in the form of a mass lesion.


METHODS
We present the case of a 73-year-old woman with intracerebral large B-cell lymphoma and concurrent WM.


CONCLUSIONS
This case illustrates the importance of histopathologic diagnosis by brain biopsy despite an existing diagnosis of systemic neoplasm.
Langevin
Jean-Philippe
JP
Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. jlangevin@mednet.ucla.edu
Bergsneider
Marvin
M
Yashar
Parham
P
Makary
Raafat F
RF
D000368:Aged; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000473:pathology* / Q000628:therapy