title: Depression in children.
abstract: OBJECTIVE
  This summary of literature published during the past year focuses on research into factors that may contribute to development of childhood-onset depression and on appropriate assessment and treatment.
  
  
  RESULTS
  The recent literature suggests that investigating risk factors and gene-environment interactions could be fruitful in elucidating the aetiology of childhood-onset depression and could have implications for developing preventive (selective or targeted programmes) and therapeutic strategies. These strategies clearly should involve interventions to improve parent-child relationships and parenting style, especially in children at high risk early in their lives. Cognitive-behavioural therapy, interpersonal therapy and (in the case of severe depression) selective serotonin reuptake inhibitor medications (fluoxetine as the first-line option, with close monitoring for adverse effects during treatment) appear to be effective in the management of depression in children. However, recent reports on psychotherapies yield a less clear picture about their effectiveness in childhood depression than was previously indicated.
  
  
  CONCLUSIONS
  Controlled trial data and evidence-based guidelines for management of depressed children are limited with respect to pharmacological and psychotherapeutic options, especially in prepubertal and preschool children. Further research in this area is therefore warranted.
authors.affiliation: Department of Child and Adolescent Psychiatry, University of Szeged, Szeged, Hungary. kapornai@gyip.szote.u-szeged.hu
authors.forename: Krisztina
authors.initials: K
authors.lastname: Kapornai
authors.forename: Agnes
authors.initials: A
authors.lastname: Vetró
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology / Q000628:therapy*; D004493:Education; D005196:Family Therapy; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D006801:Humans; D009769:Object Attachment; D011613:Psychotherapy; D012307:Risk Factors; D012931:Social Environment
chemical_list: D000928:Antidepressive Agents