Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs.
The hippocampus contains a heterogeneous population of interneurons. Parvalbumin (PV) positive neurons constitute an abundant subpopulation of cells that express GABA. The authors observed PV immunoreactivity in the hippocampal CA1 region and dentate gyrus of variously aged dogs. In 1-year-old dogs, PV immunoreactive neurons were detected in the stratum oriens of the CA1 region, and in the polymorphic layer of the dentate gyrus. In addition, weak PV immunoreactive fibers were observed in all layers in the CA1 region and dentate gyrus. In 3-year-old dogs, PV immunoreactivity was significantly higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old dogs. This finding suggests that PV immunoreactive interneurons may show high resistance to age-dependent neurodegenerative processes.
Hwang
In Koo
IK
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
Yoon
Yeo Sung
YS
Yoo
Ki-Yeon
KY
Li
Hua
H
Sun
Yuanjie
Y
Choi
Jung Hoon
JH
Lee
Choong Hyun
CH
Huh
Sung-Oh
SO
Lee
Yun Lyul
YL
Won
Moo-Ho
MH
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology; D001931:Brain Mapping; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival / Q000502:physiology; D019610:Cytoprotection / Q000502:physiology; D018891:Dentate Gyrus / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology; D010320:Parvalbumins / Q000378:metabolism*; D013045:Species Specificity; D015854:Up-Regulation
D010320:Parvalbumins; D002118:Calcium