The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP.
OBJECTIVE
To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP).


METHODS
The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The contents of some inflammatory indexes in blood were determined. The rat mortality, pathological changes of heart, the changes of NF-kappaB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels as well as apoptotic index were observed in all groups, respectively, at 3 hours, 6 hours, and 12 hours after operation.


RESULTS
The survival rate of model group was less than treated groups at 12 hours, difference was significant. The contents of some inflammatory indexes of the treated groups were lower than those of the model group to various degrees at different time points. The pathological myocardial changes under light microscope were milder in treated groups than in model group. The changes of NF-kappaB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in all groups were different. There was only a case of myocardial cell apoptosis in an Octreotide-treated group at 6 hours.


CONCLUSIONS
Baicalin and Octreotide have protecting effects on heart injury of rats with SAP.
Xiping
Zhang
Z
Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, Zhejiang Province , China. zxp99688@vip.163.com
Hua
Tian
T
Hanqing
Chen
C
Li
Chen
C
Zhiwei
Wang
W
Keyi
Wang
W
Wei
Yan
Y
Yun
Li
L
Qingyu
Li
L
Qing
He
H
Fei
Wang
W
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis; D053148:Caspase 3 / Q000096:biosynthesis; D005419:Flavonoids / Q000494:pharmacology*; D005765:Gastrointestinal Agents / Q000494:pharmacology; D006335:Heart Injuries / Q000188:drug therapy*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D015282:Octreotide / Q000494:pharmacology*; D019007:P-Selectin / Q000096:biosynthesis; D010195:Pancreatitis / Q000188:drug therapy*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D005765:Gastrointestinal Agents; D016328:NF-kappa B; D019007:P-Selectin; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; C038044:baicalin; D053148:Caspase 3; D015282:Octreotide