title: Dermatitis in a rhesus macaque (Macaca mulatta) experimentally infected with simian immunodeficiency virus.
abstract: Dermatopathies are common with human immunodeficiency virus (HIV) infection, affecting an estimated 90% of HIV patients. Opportunistic infections are common and include viral, bacterial and fungal etiologies. Dermal eruptions from highly active anti-retroviral therapy (HAART) or antibiotics such as trimethoprim-sulfamethoxazole (TMS) are also common, and can be challenging to differentiate from other causes of dermatitis. Presented is a challenging dermatology case involving a six year old male rhesus macaque experimentally infected with simian immunodeficiency virus (SIV). Skin cultures identified multi-antibiotic resistant Staphylococcus aureus, with incomplete resolution following appropriate antibiotic treatment. Skin biopsy results indicated non-specific dermatitis not consistent with typical SIV dermatitis and with a hypersensitivity component. Fungal culture revealed aspergillosis, and the patient responded favorably to oral itraconazole therapy.
authors.affiliation: Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA. wilkj@ohsu.edu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wilk
authors.forename: Anne
authors.initials: A
authors.lastname: Lewis
authors.forename: Victor
authors.initials: V
authors.lastname: Lukas
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D003872:Dermatitis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D017964:Itraconazole / Q000627:therapeutic use; D008253:Macaca mulatta; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary
chemical_list: D017964:Itraconazole