Genome-wide association studies: progress and potential for drug discovery and development.
Although genetic studies have been critically important for the identification of therapeutic targets in Mendelian disorders, genetic approaches aiming to identify targets for common, complex diseases have traditionally had much more limited success. However, during the past year, a novel genetic approach - genome-wide association (GWA) - has demonstrated its potential to identify common genetic variants associated with complex diseases such as diabetes, inflammatory bowel disease and cancer. Here, we highlight some of these recent successes, and discuss the potential for GWA studies to identify novel therapeutic targets and genetic biomarkers that will be useful for drug discovery, patient selection and stratification in common diseases.
Kingsmore
Stephen F
SF
National Center for Genome Resources, 2935 Rodeo Park Drive East, Santa Fe, New Mexico 87505, USA. sfk@ncgr.org
Lindquist
Ingrid E
IE
Mudge
Joann
J
Gessler
Damian D
DD
Beavis
William D
WD
D003920:Diabetes Mellitus / Q000235:genetics; D015195:Drug Design; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics; D009369:Neoplasms / Q000235:genetics