title: Effect of senescence on macrophage polarization and angiogenesis.
abstract: There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University, St. Louis School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Dru S
authors.initials: DS
authors.lastname: Dace
authors.forename: Rajendra S
authors.initials: RS
authors.lastname: Apte
mesh_terms: D000375:Aging / Q000276:immunology / Q000502:physiology*; D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D005123:Eye / Q000098:blood supply*; D005128:Eye Diseases / Q000209:etiology; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D008954:Models, Biological; D018919:Neovascularization, Physiologic