title: Assessment of characteristic of the vasomotor control dynamics based on plethysmographic blood flow measurement.
abstract: Enhancing the knowledge about the characteristic of the vasomotor control can help physicians to improve the treatment of cardiovascular diseases and their consequences in people's daily activities. Vessels are generally evaluated from a static point of view, where some vascular features are obtained in a given space of time, or expressed as an average of some evaluation. The present study presents a method to assess some characteristics of the vasomotor control dynamics. Such a method is based on a mathematical description of the temporal profile of the blood flow observed during a reactive hyperemia condition induced by a protocol of 5 min of ischemia. The parameters for such a mathematical descriptive function were evaluated by searching for sensitivity to identify normal and vasomotor alterations induced by oral administration of ibuprofen (1200 mg) in ten healthy volunteers. The results indicated by the proposed mathematical description fitted appropriately experimental blood flow data (fitting-error of 0.18 ml/100 ml of tissue/min). Additionally, one parameter of the mentioned function was statistically different (P < 0.05) when one considers the normal and altered conditions of the vessel, even when the traditional peak and the basal flow values did not hint at the distinction.
authors.affiliation: Department of Biomedical Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Adriana Ribeiro
authors.initials: AR
authors.lastname: de Macedo
authors.forename: Antonio Claudio Lucas
authors.initials: AC
authors.lastname: da Nobrega
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Machado
authors.forename: Marcio Nogueira
authors.initials: MN
authors.lastname: de Souza
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D010991:Plethysmography / Q000379:methods*; D012212:Rheology / Q000379:methods*; D014666:Vasomotor System / Q000502:physiology*