[Pronounced homeostatic action of angiotensin converting enzyme inhibitors with high affinity to tissue renin-angiotensin-aldosterone system on cellular membranes].
Endothelial dysfunction is considered in the paper from the point of view of pathology of cellular membranes presenting as vesiculation of cytoplasmatic membrane, release of membrane-bound microparticles, elevation of concentration of peeled off endotheliocytes in the blood. Comparative analysis of action of angiotensin converting enzyme inhibitors with various affinities to tissue renin-angiotensin-aldosterone system on the indicated parameters of pathology of cellular membranes and endothelial dysfunction has been conducted. The following mechanisms of stabilization of membranous homeostasis under influence of angiotensin converting enzyme inhibitor perindopril are discussed: action on apoptosis and activation of cells.
Inzhutova
A I
AI
Salmina
A B
AB
Petrova
M M
MM
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000494:pharmacology* / Q000627:therapeutic use; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D020913:Perindopril