Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism.
As obesity, diabetes, and associated comorbidities are on a constant rise, large efforts have been put into better understanding the cellular and molecular mechanisms by which nutrients and metabolic signals influence central and peripheral energy regulation. For decades, peripheral organs as a source and a target of such cues have been the focus of study. Their ability to integrate metabolic signals is essential for balanced energy and glucose metabolism. Only recently has the pivotal role of the central nervous system in the control of fuel partitioning been recognized. The rapidly expanding knowledge on the elucidation of molecular mechanisms and neuronal circuits involved is the focus of this review.
Rother
Eva
E
Institute for Genetics, Department of Mouse Genetics and Metabolism, Center of Molecular Medicine, University of Cologne, Cologne, Germany.
Könner
A Christine
AC
Brüning
Jens C
JC
D000818:Animals; D005947:Glucose / Q000096:biosynthesis / Q000378:metabolism*; D006728:Hormones / Q000502:physiology*; D006801:Humans; D054086:KATP Channels / Q000502:physiology; D008099:Liver / Q000378:metabolism; D009415:Nerve Net / Q000502:physiology*; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D006728:Hormones; D054086:KATP Channels; D005947:Glucose