Toward the synthesis of spirastrellolide B: a synthesis of the C1-C23 subunit.
A synthesis of the C1-C23 subunit of spirastrellolide B is described. The synthesis features two applications of a Kulinkovich-cyclopropanol ring-opening strategy for the coupling of esters with olefins to produce ketones.
Keaton
Katie A
KA
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309-0215, USA.
Phillips
Andrew J
AJ
D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D018942:Macrolides; D013141:Spiro Compounds; C519027:spirastrellolide B