Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis.
OBJECTIVE
To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces.


METHODS
Forty-eight Wistar rats, weighting between 300 g and 330 g (mean, 311,45 +/-9,67 g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied.


RESULTS
Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p<0.001), and higher in group 4 than in group 3 (p<0.01).


CONCLUSIONS
Peritoneal lavage with a 2% lidocaine saline solution without adrenaline, prevented the mortality of all animals with fecal peritonitis.
Brocco
Marcos Célio
MC
Federal University of Espírito Santo, Brazil. mcbrocco@unimedvitória.com.br
Paulo
Danilo Nagib Salomão
DN
Baptista
João Florêncio de Abreu
JF
Ferrari
Thiago Antunes
TA
Azevedo
Thiago Caetano V de
TC
Silva
Alcino Lázaro da
AL
D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005243:Feces; D008012:Lidocaine / Q000008:administration & dosage*; D010533:Peritoneal Lavage / Q000009:adverse effects / Q000379:methods*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride
D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D012965:Sodium Chloride; D008012:Lidocaine