Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide.
OBJECTIVE
To evaluate the effects of Metformin and Glyburide on cardiovascular, metabolic and hormonal parameters during progressive exercise performed to exhaustion in the post-prandial state in women with type 2 diabetes (T2DM).


METHODS
Ten T2DM patients treated with Metformin (M group), 10 with Glyburide (G group) and 10 age-paired healthy subjects exercised on a bicycle ergometer up to exercise peak. Cardiovascular and blood metabolic and hormonal parameters were measured at times -60 min, 0 min, exercise end, and at 10 and 20 minutes of recovery phase. Thirty minutes before the exercise, a standard breakfast was provided to all participants. The diabetic patients took Metformin or Glyburide before or with meal.


RESULTS
Peak oxygen uptake (VO(2)) was lower in patients with diabetes. Plasma glucose levels remained unchanged, but were higher in both diabetic groups. Patients with diabetes also presented lower insulin levels after meals and higher glucagon levels at exercise peak than C group. Serum cortisol levels were higher in G than M group at exercise end and recovery phase. Lactate levels were higher in M than G group at fasting and in C group at exercise peak. Nor epinephrine, GH and FFA responses were similar in all 3 groups.


CONCLUSIONS
Progressive exercise performed to exhaustion, in the post-prandial state did not worsen glucose control during and after exercise. The administration of the usual dose of Glyburide or Metformin to T2DM patients did not influence the cardiovascular, metabolic and hormonal response to exercise.
Cunha
M R
MR
Laboratory of Medical Investigation LIM-18, and Endocrine Service, Hospital das Clinicas - University of São Paulo Medical School, São Paulo, Brazil. maria_cunha@uol.com.br
Silva
M E R
ME
Machado
H A
HA
Fukui
R T
RT
Correia
M R S
MR
Santos
R F
RF
Wajchenberg
B L
BL
Rocha
D M
DM
Rondon
M U P B
MU
Negrão
C E
CE
Ursich
M J M
MJ
D001786:Blood Glucose / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D015444:Exercise / Q000502:physiology; D017079:Exercise Tolerance; D005221:Fatigue / Q000209:etiology*; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006728:Hormones / Q000097:blood; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged
D001786:Blood Glucose; D006728:Hormones; D007004:Hypoglycemic Agents; D008687:Metformin; D005905:Glyburide