title: Hemodynamic blood flow disturbances in the middle cerebral arteries in patients with atrial fibrillation during acute ischemic stroke.
abstract: OBJECTIVE
  The purpose of the present study was to evaluate whether blood flow in the middle cerebral arteries (MCAs) in patients with atrial fibrillation (AF) during acute ischemic stroke is disturbed, as well as to assess if potential disturbances result from arrhythmia rather than a consequence of an embolus within the cerebral circulation.
  
  
  METHODS
  A total of 180 subjects were included in the study; 90 consecutive patients with AF and 90 consecutive patients in sinus rhythm who were admitted to the Stroke Unit of the Department of Neurology at Pomeranian Medical University Hospital in Szczecin, Poland within 24h of the onset of ischemic stroke symptoms. During the acute phase of the stroke (24h), all patients underwent transcranial Doppler ultrasonography (TCD) with assessment of mean blood flow velocity (MV) in the MCAs.
  
  
  RESULTS
  We observed significantly lower values of MV in MCAs of both damaged and intact hemispheres in patients with AF as compared to patients in sinus rhythm.
  
  
  CONCLUSIONS
  In patients with AF, hemodynamic disturbances occur within the cerebral circulation during acute ischemic stroke which can cause a more severe course and worse stroke outcome. AF patients need more appropriate prevention of stroke, as well as more efficient treatment during acute ischemic stroke.
authors.affiliation: Department of Neurology, University Hospital, Pomeranian Medical University of Szczecin, Unii Lubelskiej 1 Street, 71-252 Szczecin, Poland. agatka104@yahoo.com
authors.forename: Agata
authors.initials: A
authors.lastname: Porebska
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Nowacki
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Marta
authors.initials: M
authors.lastname: Nowik
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications* / Q000503:physiopathology; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000502:physiology; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000209:etiology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial