title: Selective synthesis of spiro[4,5]trienyl acetates via an intramolecular electrophilic ipso-iodocyclization process.
abstract: A general and efficient intramolecular electrophilic ipso-iodocyclization of para-unactivated arylalkynes has been developed for the synthesis of spiro[4,5]trienyl acetates. In the presence of NIS (N-iodosuccimide) and HOAc, para-unactivated arylalkynes, including N-arylpropiolamides and phenyl 3-phenylpropiolate, underwent the intramolecular electrophilic ipso-iodocyclization smoothly in moderate to good yields.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Hunan Normal University, Changsha, China.
authors.forename: Bo-Xiao
authors.initials: BX
authors.lastname: Tang
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: Tang
authors.forename: Shi
authors.initials: S
authors.lastname: Tang
authors.forename: Quan-Fu
authors.initials: QF
authors.lastname: Yu
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Liang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000085:Acetates