Allogeneic stem cell transplantation in a patient with relapsed Ewing sarcoma.
Ewing sarcoma (ES) can express tumor antigens which can be recognized by T cells, making allogeneic stem cell transplant (SCT) a potential option for those patients with refractory disease. A 6-year old with multifocal ES developed a recurrence of pulmonary metastases and underwent an allogeneic bone marrow transplant from her human leukocyte antigen (HLA) 10/10 matched mother. During a taper of her immunosuppression, she developed grade 1 skin and oral graft versus host disease (GVHD). CT scans performed 9 months post-transplant revealed a marked decrease in the size of her pulmonary lesions compared to scans 2 months post-transplant. This case highlights the possibility of treating patients with refractory metastatic ES with allogeneic SCT.
Lucas
Kenneth G
KG
Division of Pediatric Hematology-Oncology, Stem Cell Transplantation Program, Penn State Children's Hospital, Hershey, Pennsylvania, USA. klucas@psu.edu
Schwartz
Cindy
C
Kaplan
Joel
J
D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D012512:Sarcoma, Ewing / Q000473:pathology / Q000628:therapy*; D014184:Transplantation, Homologous; D016896:Treatment Outcome