title: Synthesis, characterization and DNA-binding studies of 1-cyclohexyl-3-tosylurea and its Ni(II), and Cd(II) complexes.
abstract: 1-Cyclohexyl-3-tosylurea (HL) and its two complexes, ML2.2H2O [M=Ni(1), and Cd(2)], have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra and thermal analyses. In addition, the DNA-binding properties of the ligand and the two complexes have been investigated by electronic absorption, fluorescence, CD spectroscopy and viscosity measurements. The experiment results suggest that the ligand and its two complexes bind to DNA via a groove binding mode, and the binding affinity of the complex 2 is higher than that of the complex 1 and the ligand.
authors.affiliation: College of Chemistry and Chemical Engineering and State Key Laboratory Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Pin-xian
authors.initials: PX
authors.lastname: Xi
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Xu
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Feng-juan
authors.initials: FJ
authors.lastname: Cheng
authors.forename: Zheng-zhi
authors.initials: ZZ
authors.lastname: Zeng
mesh_terms: D000042:Absorption; D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry*; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D004583:Electrons; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013053:Spectrophotometry; D017186:Titrimetry; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry; D014783:Viscosity
chemical_list: C529360:1-cyclohexyl-3-tosylurea; D019187:Cadmium Compounds; D008024:Ligands; D009532:Nickel; D014508:Urea; D004247:DNA; C427203:calf thymus DNA