Informatic innovations in glycobiology: relevance to drug discovery.
The recent development and applications of tree-based informatics on glycans have accelerated the biological analysis on glycans, particularly from structural viewpoints. We review three major aspects of recent informatics innovations on glycan structures: maturity of well-organized databases on glycan structures linking with other biological information, implementation of glycan structure matching algorithms and extensive development of methods for mining frequent patterns from glycan structures.
Mamitsuka
Hiroshi
H
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji 611-0011, Japan. mami@kuicr.kyoto-u.ac.jp
D015195:Drug Design; D054794:Glycomics / Q000379:methods*; D006801:Humans; D048088:Informatics / Q000379:methods*; D015233:Models, Statistical; D008968:Molecular Conformation; D011134:Polysaccharides / Q000737:chemistry
D011134:Polysaccharides