A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes.
Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.
Huang
Chun-Ming
CM
Division of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm. 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA. chunming@ucsd.edu
Torpey
Justin W
JW
Liu
Yu-Tseung
YT
Chen
Yun-Ru
YR
Williams
Katherine E
KE
Komives
Elizabeth A
EA
Gallo
Richard L
RL
D000328:Adult; D000595:Amino Acid Sequence; D005260:Female; D005973:Glutamine / Q000737:chemistry; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011392:Proline / Q000737:chemistry; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000254:growth & development; D012463:Saliva / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D010455:Peptides; D012471:Salivary Proteins and Peptides; D005973:Glutamine; D011392:Proline