title: Comparative therapeutic effect of toltrazuril, sulphadimidine and amprolium on Eimeria bovis and Eimeria zuernii given at different times following infection in buffalo calves (Bubalus bubalis).
abstract: We compared the therapeutic effect of three anticoccidial drugs (toltrazuril, sulphadimidine and amprolium) in buffalo (Bubalus bubalis) calves experimentally infected with Eimeria bovis (E. bovis) and E. zuernii oocysts (3 x 104oocyst/calf). Buffalo calves (1.5-4 month old, 70-kg body weight) were randomly allocated into 3 groups (9 calves each). Group T was experimentally infected with oocysts and treated with toltrazuril (20 mg/kg BW twice orally at a 1-week interval). Group S was experimentally infected with oocysts and treated with sulphadimidine (125 mg/kg injected IM followed by half dose for 4 successive days). Group A was experimentally infected with oocysts and treated with amprolium (50 mg/kg orally for 7 successive days). Each group had three subgroups (three calves/subgroup) to represent timing of the drug administration: 1st day of coccidia infection (FD), onset of clinical signs of coccidiosis (CC), and onset of oocyst shedding into the faeces (OS). Clinical signs, body-weight gain (BWG) and number of oocysts per gram feces (OPG) were monitored daily for 35 days post-infection (DPI). The OPG were reduced (but the BWG was not different) in the T calves compared to S and A calves. Within the same group, treatment from the 1st day of infection reduced the OPG and increased the BWG compared to the later treatment timings.
authors.affiliation: Animal Medicine Department, College of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt. dr.mohamedghanem@yahoo.com
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Ghanem
authors.forename: Mervat E
authors.initials: ME
authors.lastname: Radwaan
authors.forename: Abdel Moneim M
authors.initials: AM
authors.lastname: Moustafa
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Ebeid
mesh_terms: D000670:Amprolium / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002020:Buffaloes / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004539:Eimeria / Q000187:drug effects*; D005243:Feces / Q000469:parasitology; D013424:Sulfanilamides / Q000008:administration & dosage / Q000627:therapeutic use*; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*; D015430:Weight Gain
chemical_list: D003049:Coccidiostats; D013424:Sulfanilamides; D014227:Triazines; C043086:sulfamethomidine; D000670:Amprolium; C036670:toltrazuril