title: Creation of polynucleotide-assisted molecular assemblies in organic solvents: general strategy toward the creation of artificial DNA-like nanoarchitectures.
abstract: The influence of added polynucleotide on the gelation ability of nucleobase-appended organogelators was investigated. Uracil-appended cholesterol gelator formed a stable organogel in polar organic solvents such as n-butanol. It was found that the addition of the complementary polyadenylic acid (poly(A)) not only stabilizes the gel but also creates the helical structure in the original gel phase. Thymidine and thymine-appended gelators can form stable gel in apolar solvents, such as benzene, where poly(A)-lipid complex can act as a complementary template for the gelator molecules to create the fibrous composites. Based on these findings, we can conclude that self-assembling modes and gelation properties of nucleobase-appended organogelators are controllable by the addition of their complementary polynucleotide in organic solvents. We believe, therefore, that the present system can open the new paths to accelerate development of well-controlled one-dimensional molecular assembly systems, which would be indispensable for the creation of novel nanomaterials based on organic compounds.
authors.affiliation: Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 819-0395, Japan.
authors.forename: Munenori
authors.initials: M
authors.lastname: Numata
authors.forename: Kazunori
authors.initials: K
authors.lastname: Sugiyasu
authors.forename: Takanori
authors.initials: T
authors.lastname: Kishida
authors.forename: Shuichi
authors.initials: S
authors.lastname: Haraguchi
authors.forename: Norifumi
authors.initials: N
authors.lastname: Fujita
authors.forename: Sun Min
authors.initials: SM
authors.lastname: Park
authors.forename: Young Ji
authors.initials: YJ
authors.lastname: Yun
authors.forename: Byeang Hyean
authors.initials: BH
authors.lastname: Kim
authors.forename: Seiji
authors.initials: S
authors.lastname: Shinkai
mesh_terms: D000438:Alcohols / Q000737:chemistry; D001554:Benzene / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D011119:Polynucleotides / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013936:Thymidine / Q000737:chemistry; D013941:Thymine / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000438:Alcohols; D005782:Gels; D008055:Lipids; D009930:Organic Chemicals; D011119:Polynucleotides; D012997:Solvents; D014867:Water; D004247:DNA; D001554:Benzene; D013941:Thymine; D013936:Thymidine