title: A putative role for apelin in the etiology of obesity.
abstract: Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.
authors.affiliation: Department of Animal & Dairy Science, University of Georgia, 444 Animal Science Complex, Athens, GA 30602-2771, USA.
authors.forename: Srujana
authors.initials: S
authors.lastname: Rayalam
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Della-Fera
authors.forename: Paul A
authors.initials: PA
authors.lastname: Krieg
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Cox
authors.forename: Allan
authors.initials: A
authors.lastname: Robins
authors.forename: Clifton A
authors.initials: CA
authors.lastname: Baile
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply* / Q000378:metabolism*; D000818:Animals; D000073861:Apelin; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009765:Obesity / Q000209:etiology* / Q000378:metabolism*
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins