Histological study on acute inflammatory reaction to polyurethane-coated silicone implants in rats.
OBJECTIVE
Evaluating histologically the silicone peri-implant coated by polyurethane inflammation associated to the use of anti-microbial and bacterial contamination.


METHODS
It was used 35 Wistar rats. The animals were divided in seven groups: I - Control; II - implant cavity contamination with 10 bacteria/ml; III - implant cavity contamination with 10 bacteria/ml; IV - implant cavity contamination with 10 bacteria/ml; V - identical contamination to group II and implant immersions in anti-microbial solution; VI - identical contamination in group III and implant immersions in the anti-microbial solution; VII - identical contamination of group IV and implant immersions in anti-microbial solution. It was evaluated morphometrically the peri-implant capsules after 30 days of introduction.


RESULTS
The factors with more discriminating power were the giants cells of a strange body and the mononuclear. There was no correlation between the bacterial concentrations and the histological alterations.


CONCLUSIONS
1) The histological standard of the inflammatory reaction around the silicone implant coated with polyurethan is chronic granulomatosis type of a strange body; 2) There isn't correlation between concentration of Staphylococcus epidermidis and histological changes; 3) The use of anti-microbial solution decreased the mononuclear cell reactions, with the increase of giant cells in a strange body.
Mendes
Paulo Roberto da Silva
PR
University Hospital, Santa Catarina, Brazil.
Bins-Ely
Jorge
J
Lima
Eduardo Arnaut Dos Santos
EA
Vasconcellos
Zulmar Antonio Accioli de
ZA
d'Acampora
Armando José
AJ
Neves
Rodrigo D' Eça
RD
D000818:Animals; D001672:Biocompatible Materials; D018427:Breast Implants / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005549:Foreign-Body Reaction / Q000382:microbiology / Q000473:pathology*; D020007:Implants, Experimental; D011140:Polyurethanes; D051381:Rats; D017208:Rats, Wistar; D020034:Silicone Gels / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology; D013212:Staphylococcus epidermidis / Q000302:isolation & purification
D001672:Biocompatible Materials; D011140:Polyurethanes; D020034:Silicone Gels