Preparation and properties of a silybin-phospholipid complex.
Due to its poor solubility in water and oil, silybin is hardly absorbed orally and cannot be dissolved directly for parenteral preparations. In this study, a silybin-phospholipid complex was prepared by single-factor design and orthogonal experimental design. Lipophilicity was improved to a large extent, which was determined by solubility experiments and oil/water partition studies. Various methods were used to confirm the formation and explore the properties of the silybin-phospholipid complex, such as UV, IR, ATR, CNMR, XRD,DSC, SEM and TEM. The structure of the phytosome when the complex was dispersed in aqueous solution is suggested.
Song
Yunmei
Y
Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China.
Zhuang
Jie
J
Guo
Jianxin
J
Xiao
Yanyu
Y
Ping
Qineng
Q
D000975:Antioxidants / Q000737:chemistry*; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003890:Desiccation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009821:Oils / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014280:Triglycerides / Q000737:chemistry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000975:Antioxidants; D007202:Indicators and Reagents; D009821:Oils; D010743:Phospholipids; D012838:Silymarin; D012997:Solvents; D014280:Triglycerides; D014867:Water; D000077385:Silybin