Shared principles in NF-kappaB signaling.
The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.
Hayden
Matthew S
MS
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Ghosh
Sankar
S
D000818:Animals; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D020672:I-kappa B Proteins / Q000378:metabolism; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
C083487:I kappa B beta protein; D020672:I-kappa B Proteins; D016328:NF-kappa B; D051550:I-kappa B Kinase