Photochemical DNA cleavage by novel water-soluble sulfonated dihydroxy phosphorus(V) tetrabenzotriazacorrole.
The photosensitizing properties of a novel water-soluble phthalocyanine-like photosensitizer, sulfonated dihydroxy phosphorus(V) tetrabenzotriazacorrole {P(OH)(2)TBCS(n)}, have been reported. It is relevant for the use of this dye as photodynamic sensitizer. The compound exhibited significant photocleavage of supercoiled (SC) pUC19 DNA. The photooxygenation and photocleavage to DNA showed high efficiency in generating singlet oxygen.
Huang
Lei
L
The Key Lab of Organic Photoelectrons & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Haidian, Beijing 100084, People's Republic of China.
Zhong
Cheng
C
Zhang
Fushi
F
Tung
Chen-Ho
CH
D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects* / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D007259:Infrared Rays; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D026082:Singlet Oxygen
D009943:Organophosphorus Compounds; C529344:P(OH)(2)TBCS(n); D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D004247:DNA