title: Aspergillus "fungus ball" of the bladder after hematopoietic transplantation in a pediatric patient: successful treatment with intravesical voriconazole and surgery.
abstract: Aspergillosis is an important cause of mortality in allogeneic HSCT. A "fungus ball" formation of Aspergillus in the bladder has seldom been reported. We report a child that underwent HSCT and developed possible disseminated aspergillosis with an intravesical "fungus ball," diagnosed by genitourinary MRI and PCR of the mass that was removed from the bladder. It is important to consider this complication in a patient with HC after HSCT. The treatment included a combination of systemic antifungal therapy along with intravesical voriconazole and surgical removal.
authors.affiliation: Pediatric Hematology-Oncology Section, Hospital Niño Jesús, Madrid, Spain. mgonzalezv.hnjs@salud.madrid.org
authors.forename: Marta
authors.initials: M
authors.lastname: González-Vicent
authors.forename: Alvaro
authors.initials: A
authors.lastname: Lassaletta
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: López-Pino
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Romero-Tejada
authors.forename: Manuel
authors.initials: M
authors.lastname: de la Fuente-Trabado
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Díaz
mesh_terms: D000283:Administration, Intravesical; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000628:therapy; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D003556:Cystitis / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D001745:Urinary Bladder Diseases / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole