Specialized perinodal fat fuels and fashions immunity.
Adipose tissue around lymph nodes is usually removed prior to the study of immune activity-but is it time to reconsider this practice? Perinodal adipose tissue may provide not only a specific lipid resource but also fatty acids, dendritic cells, and soluble mediators that modulate local immunity.
Knight
Stella C
SC
Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark's Campus, Watford Road, Harrow, UK. s.knight@imperial.ac.uk
D017667:Adipocytes / Q000276:immunology / Q000378:metabolism*; D000273:Adipose Tissue / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D005227:Fatty Acids / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007109:Immunity; D008198:Lymph Nodes / Q000276:immunology* / Q000378:metabolism*
D016207:Cytokines; D005227:Fatty Acids