title: Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline.
abstract: Tetrahydrozoline is an imidazoline derivative with alpha receptor agonist activity widely available in over-the-counter topical ocular and nasal formulations. More than 1,600 cases of oral exposures are reported to United States poison centers annually (1,2). Reports of significant toxicity from tetrahydrozoline ingestion are unusual but have occured primarily in small children after unintentional ingestion (3-63, 6). We report a case of unintentional tetrahydrozoline ingestion with cardiovascular effects persisting for 36 hours.
authors.affiliation: Kentucky Regional Poison Center, Louisville, Kentucky 40232-5070, USA. henry.spiller@nortonhealthcare.org
authors.forename: Henry
authors.initials: H
authors.lastname: Spiller
authors.forename: Jill
authors.initials: J
authors.lastname: Griffith
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001919:Bradycardia / Q000139:chemically induced* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000506:poisoning*; D008508:Medication Errors; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000506:poisoning; D012646:Self Administration; D013997:Time Factors
chemical_list: D007093:Imidazoles; D009883:Ophthalmic Solutions; C005810:tetrahydrozoline