title: Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during progression.
abstract: A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy showed duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.
authors.affiliation: The First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsurumi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kato
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Imao
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kojima
authors.forename: Keishi
authors.initials: K
authors.lastname: Kojima
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kitagawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Katsumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Araki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takami
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D018450:Disease Progression; D004379:Duodenal Neoplasms / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D007161:Immunoproliferative Small Intestinal Disease / Q000150:complications* / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism
chemical_list: D011506:Proteins