An acute intracerebral vein thromboses in AIDS with protein C and S deficiency.
A 22-year-old woman with advanced AIDS presented with altered mental status. A brain magnetic resonance imaging and angiogram showed extensive dural sinus thromboses of the sagittal and bilateral transverse sinuses. CD4 level was low (<15/mm3) and a significant low protein S (7%; normal 54-137%) and C (41%; normal 72-147%) levels were detected. No other hypercoagulable factors were identified. Successful treatment was done with heparin and plasminogen activator catheter-directed thrombolysis were administered. A variety of haematological abnormalities have been observed in human immunodeficiency virus infection. Advanced AIDS might be considered as an acquired hypercoagulable state.
Marcos
Luis A
LA
Internal Medicine Department, University of Texas Health Science, Houston, TX 77030, USA. Luis.A.Marcos@uth.tmc.edu
Majid
Ruckshanda
R
Hamzeh
Nabeel
N
Mehta
Niraj
N
Escobar
Miguel
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D018791:CD4 Lymphocyte Count; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D020767:Intracranial Thrombosis; D018810:Magnetic Resonance Angiography; D010960:Plasminogen Activators / Q000627:therapeutic use; D020151:Protein C Deficiency / Q000150:complications*; D018455:Protein S Deficiency / Q000150:complications*; D011859:Radiography; D015912:Thrombolytic Therapy / Q000379:methods
D006493:Heparin; D010960:Plasminogen Activators