title: Comparison of long-term angiographic follow-up after sirolimus-eluting stent and bare-metal stent implantation.
abstract: BACKGROUND
  The sirolimus-eluting stent (SES) has dramatically reduced the rate of restenosis in comparison to that with the bare-metal stent (BMS). In previous studies, the minimal luminal diameter (MLD) of lesions treated with a BMS was shown to improve from 6 months to 1 year.
  
  
  METHODS
  To evaluate 6-month and 1-year outcomes, angiographic follow-up data were analyzed for 285 patients (451 lesions) who underwent successful SES implantation compared to follow-up data for 2,561 patients (3,367 lesions) who underwent BMS implantation.
  
  
  RESULTS
  Angiographic follow-up was performed at 6 months for 396 SES-treated lesions and 2,628 BMS-treated lesions and at 1 year for 322 SES-treated lesions and 1,540 BMS-treated lesions. The 6-month angiographic restenosis rate was significantly lower for SES-treated lesions than for BMS-treated lesions (4.8% vs. 23.4%, p<0.01). From immediately after stent implantation to 6 months, quantitative coronary angiography revealed a significantly larger decrease in MLD of BMS-treated lesions than in MLD of SES-treated lesions (p<0.01). In BMS-treated lesions in which repeat revascularization was not performed at 6 months, MLD increased significantly from 2.08+/-0.63 mm at 6 months to 2.11+/-0.61 mm at 1 year (p<0.01). In SES-treated lesions, however, MLD decreased significantly from 2.55+/-0.56 mm at 6 months to 2.44+/-0.61 mm at 1 year (p<0.05).
  
  
  CONCLUSIONS
  From 6 months to 1 year, stenosis of BMS-treated lesions regressed, but stenosis of SES-treated lesions progressed.
authors.affiliation: Department of Cardiology, Matsue Red Cross Hospital, Matsue, Japan. nobucode.0317@kfd.biglobe.ne.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shiode
authors.forename: Kinya
authors.initials: K
authors.lastname: Shirota
authors.forename: Kenji
authors.initials: K
authors.lastname: Goto
authors.forename: Akinori
authors.initials: A
authors.lastname: Sairaku
authors.forename: Shinya
authors.initials: S
authors.lastname: Mikami
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kato
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Suenari
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Ishi
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000628:therapy*; D054855:Drug-Eluting Stents; D005500:Follow-Up Studies; D006801:Humans; D011474:Prosthesis Design; D020123:Sirolimus / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D020123:Sirolimus