title: Anti-BK virus activity of nucleoside analogs.
abstract: Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.
authors.affiliation: Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA. randhawapa@upmc.edu
authors.forename: Parmjeet
authors.initials: P
authors.lastname: Randhawa
authors.forename: Jiri
authors.initials: J
authors.lastname: Zemlicka
authors.forename: Andreas
authors.initials: A
authors.lastname: Sauerbrei
authors.forename: Chris
authors.initials: C
authors.lastname: Meier
authors.forename: Karl Y
authors.initials: KY
authors.lastname: Hostetler
authors.forename: James R
authors.initials: JR
authors.lastname: Beadle
authors.forename: Noush Afarin
authors.initials: NA
authors.lastname: Farasati
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Huang
authors.forename: Matthews
authors.initials: M
authors.lastname: Bradley
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D001739:BK Virus / Q000187:drug effects* / Q000502:physiology; D004952:Esters / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D004952:Esters; D005227:Fatty Acids; D009705:Nucleosides; D063065:Organophosphonates; C053001:adefovir; C050127:9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine; D000225:Adenine