title: Platelet glycoprotein Ibalpha gene polymorphism and massive or submassive pulmonary embolism.
abstract: OBJECTIVE
  The -5T/C polymorphism in the Kozak sequence of glycoprotein Ibalpha, a component of the platelet glycoprotein Ib-IX-V receptor complex, is associated with an increase in this receptor density on the surface of the platelet. This study was designed to investigate the effect of platelet glycoprotein Ibalpha Kozak polymorphism on the clinical presentation of the patients with acute pulmonary embolism.
  
  
  METHODS
  Forty-two patients with pulmonary embolism were genotyped for Kozak polymorphism of the glycoprotein Ibalpha by polymerase chain reaction/restriction fragment length polymorphism.
  
  
  RESULTS
  Carriers of the -5T/C polymorphism of glycoprotein Ibalpha were significantly over-represented in the patient group with clinically massive or submassive pulmonary embolism (odds ratio 5.5, 95% confidence interval 1.4 to 22.2, P = 0.023). Also the association between this polymorphism and massive or submassive pulmonary embolism still existed even after being adjusted for conventional risk factors.
  
  
  CONCLUSIONS
  The -5T/C polymorphism in the Kozak sequence of glycoprotein Ibalpha may present as a risk factor for clinical manifestation of pulmonary embolism in which clot burden plays an important role.
authors.affiliation: Department of Cardiology, Meram Medical School of Selcuk University, S.U. Meram Tip Fakültesi Kardiyoloji AD, Konya, Turkey. asoylu44@gmail.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Soylu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tokaç
authors.forename: Tülin
authors.initials: T
authors.lastname: Cora
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Düzenli
authors.forename: Hasan
authors.initials: H
authors.lastname: Acar
mesh_terms: D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011655:Pulmonary Embolism / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
chemical_list: D019038:Platelet Glycoprotein GPIb-IX Complex; C023592:glycocalicin