Costimulation and allergic responses: immune and bioinformatic analyses.
Asthma is a complex polygenic disease, the prevalence of which has been on the rise for last few decades. Defining the underpinnings of allergic immune responses and the factors predisposing to asthma are fundamental investigative challenges. T cell costimulatory pathways play critical roles in the pathogenesis of asthma. In this review, we analyze the current state of the art of T cell costimulation in allergic airway inflammation. Also, we discuss both immune and bioinformatic approaches as potential strategies for analyzing multiple costimulatory pathways relevant to asthma.
Jain
Vipul V
VV
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92093, United States. vjcriticalcare@gmail.com
Perkins
David L
DL
Finn
Patricia W
PW
D000208:Acute Disease; D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology; D001249:Asthma / Q000209:etiology / Q000276:immunology*; D018106:CD28 Antigens / Q000502:physiology; D060908:CTLA-4 Antigen; D002908:Chronic Disease; D019295:Computational Biology; D006801:Humans; D060889:Inducible T-Cell Co-Stimulator Protein; D007249:Inflammation / Q000276:immunology; D051379:Mice; D012137:Respiratory System / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C556707:Ctla4 protein, mouse; C556692:ICOS protein, human; C556694:Icos protein, mouse; D060889:Inducible T-Cell Co-Stimulator Protein