[Relationships of nucleotide, amino acid sequence and secondary structure of protein and molecular design].
May the structure information of protein be obtained from the corresponding nucleotide sequence? For this question, a computer program was used to conduct a statistical analysis about the clustering phenomena of amino acids. In this method, 20 kinds of amino acid were classified into 2 types according to the number of hydrogen bonds formed by middle base of their correlation codons. It can be seen that amino acid has a rather great possibility of neighboring on another of its class and this assembly has a tendency to forming specific secondary structure. A sequence was designed and its secondary structure was predicted by this prediction software.
Ma
Peng
P
Life College of Science and Engineering, Shaanxi University of Science & Technology, Xianyang, 712081, China. mapeng_true@yahoo.com.cn
Wang
Lian-Jie
LJ
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000145:classification*; D016000:Cluster Analysis; D009711:Nucleotides / Q000737:chemistry* / Q000235:genetics; D017433:Protein Structure, Secondary / Q000235:genetics*; D020539:Sequence Analysis, Protein / Q000379:methods
D000596:Amino Acids; D009711:Nucleotides