Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation.
Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPARalpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes.
Kang
Min-Sook
MS
Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Hirai
Shizuka
S
Goto
Tsuyoshi
T
Kuroyanagi
Kayo
K
Lee
Joo-Young
JY
Uemura
Taku
T
Ezaki
Yoichiro
Y
Takahashi
Nobuyuki
N
Kawada
Teruo
T
D041721:3T3-L1 Cells; D045784:Abietanes / Q000008:administration & dosage*; D017667:Adipocytes / Q000187:drug effects / Q000276:immunology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002460:Cell Line; D007249:Inflammation / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D008024:Ligands; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D047493:PPAR alpha / Q000276:immunology*; D047495:PPAR gamma / Q000276:immunology*
D045784:Abietanes; D000893:Anti-Inflammatory Agents; D008024:Ligands; D047493:PPAR alpha; D047495:PPAR gamma; C013913:dehydroabietic acid