title: [Effect of the estrous cycle stage on sensitivity to pheromone 2,5-dimethylpyrazine in the house mouse Mus musculus].
abstract: Frequency of cytogenetic disturbances was estimated in mitotically dividing bone marrow cells of CBA strain female mice after the 24-h long action of pheromone 2,5-dimethylpyrazine (2,5-DMP). The stage of the estrous cycle of each animal was taken into account at the moment of the end of the pheromone action. The analysis was performed using the anatelophase method that allows evaluating frequencies of various types of disturbances--bridges, fragments, delayed chromosomes. The spontaneous level of the mitotic disturbances revealed by the anatelophase method in animals of the control group amounts to 5.4 %. Action of pheromone 2,5-dimethylpyrasine induced the mitosis disturbances detected in the dividing bone marrow cells at the anaphase-telophase stage in the females at the di- + postestrus stage. The corresponding frequency of disturbances after the pheromone action was equal to 9.2%. In the female in estrus, the mitotic disturbance level amounted 6.7%, which did not differ statistically significantly from control. It is suggested that differences in the female mouse hormonal state at different estrous cycle stages affect sensitivity to olfactory signals. Mechanisms of the revealed effect and significance of the differences in sensitivity to pheromone for reproductive processes are discussed.
authors.forename: E V
authors.initials: EV
authors.lastname: Daev
authors.forename: A V
authors.initials: AV
authors.lastname: Dukel'skaia
authors.forename: V E
authors.initials: VE
authors.lastname: Kazarova
authors.forename: Ia A
authors.initials: IaA
authors.lastname: Fil'kina
mesh_terms: D000705:Anaphase / Q000187:drug effects*; D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D002869:Chromosome Aberrations / Q000187:drug effects*; D030762:Estrous Cycle / Q000378:metabolism*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D010675:Pheromones / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D013692:Telophase / Q000187:drug effects*; D013997:Time Factors
chemical_list: D010675:Pheromones; D011719:Pyrazines; C075524:2,5-dimethylpyrazine