title: Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations.
abstract: We present a giant tumor of the skull base compressing the brain in a 40-years-old man. The tumor was policystic at imaging. Its histopathology, immunohistochemical profile and long evolution suggest an endolymphatic sac tumor (ELST), a rare case of neoplasia. Since the patient had multiple otolaryngological procedures in his medical history, a possible traumatic pathogenesis could be suspected. On the other way, some immunohistochemical aspects found in our case may imply a histogenesis divergent from that currently accepted. This could be from either the organ of Corti or some local cells that generate a resemblance with a systemic tumor, the so-called benign mesothelioma. Further studies are needed in order to clarify this topic.
authors.affiliation: Department of Histopathology and Immunohistochemistry, Victor Babeş National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania. dorelarsene@yahoo.com
authors.forename: D
authors.initials: D
authors.lastname: Arsene
authors.forename: Alina
authors.initials: A
authors.lastname: Georgescu
authors.forename: L
authors.initials: L
authors.lastname: Dănăilă
authors.forename: Carmen
authors.initials: C
authors.lastname: Ardeleanu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D004712:Endolymphatic Sac / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D019292:Skull Base Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor