title: [Human HSF1 mutants and their applications].
abstract: Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional activity, which dominant-negative HSF1 does not acquire. In this paper, the progress of using these HSF1 mutants in the research of cancer, neurodegenerative disorders and cardiovascular diseases will be discussed.
authors.affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China.
authors.forename: Yun-Hong
authors.initials: YH
authors.lastname: Huang
authors.forename: Shou-Fang
authors.initials: SF
authors.lastname: Gong
authors.forename: Jiang-Ying
authors.initials: JY
authors.lastname: Zou
mesh_terms: D015316:Genetic Therapy; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000627:therapeutic use; D006801:Humans; D050505:Mutant Proteins / Q000235:genetics*; D009369:Neoplasms / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000628:therapy*
chemical_list: D006360:Heat-Shock Proteins; D050505:Mutant Proteins