title: Racial differences in disease extent and severity in patients with ulcerative colitis: a retrospective cohort study.
abstract: BACKGROUND
  Ulcerative colitis (UC) is increasing in African-Americans (AA). The objectives of this study were to assess disease extent and severity in UC by race.
  
  
  METHODS
  Disease extent and severity was assessed in UC outpatients evaluated at the University of Maryland and Baltimore VA from 1997 to 2005.
  
  
  RESULTS
  About 197 patients were identified; 47 were AA (23%). Of AA, 23% had proctitis, 23% had left-sided colitis, and 53% had extensive colitis compared to 10%, 31%, and 59% of Caucasians, respectively (P = 0.056). African-Americans were less likely to ever receive steroids (45% versus 62%; P = 0.065), be treated with > or = 2 courses of steroids (54% versus 68%; P = 0.242) or be steroid dependant (33% versus 46%; P = 0.304). After adjustment, only female gender (OR 0.32, [0.16-0.66]) and age at diagnosis (OR 2.50, [1.28-4.90]) were associated with extensive colitis. Being seen at UMMS (OR 5.10, [2.60-10.10]) was associated with steroid use.
  
  
  CONCLUSIONS
  Race was not associated with extent of colitis or disease severity in UC.
authors.affiliation: Veterans Affairs, Maryland Health Care System, Baltimore, MD, USA.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Flasar
authors.forename: Sandra
authors.initials: S
authors.lastname: Quezada
authors.forename: Priti
authors.initials: P
authors.lastname: Bijpuria
authors.forename: Raymond K
authors.initials: RK
authors.lastname: Cross
mesh_terms: D000328:Adult; D001741:Black or African American / Q000208:ethnology*; D015331:Cohort Studies; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000208:ethnology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008396:Maryland; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use; D044465:White People / Q000208:ethnology*
chemical_list: D013256:Steroids