Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis.
Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregulation of p53 in mouse cryptorchidism. Furthermore, in vitro over-expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat-induced apoptosis with a marked impairment of p53 expression. These findings indicate that Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis.
Li
Wei
W
Department of Histology and Embryology, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
Bao
Wei
W
Ma
Jing
J
Liu
Xinping
X
Xu
Ruojun
R
Wang
Rui-an
RA
Zhang
Yuanqiang
Y
D000818:Animals; D017209:Apoptosis; D003456:Cryptorchidism / Q000378:metabolism; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012097:Repressor Proteins; D013090:Spermatocytes / Q000378:metabolism; D013091:Spermatogenesis; D013737:Testis / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
C503336:Mta1 protein, mouse; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53