Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study.
OBJECTIVE
To determine the impact of previous coronary artery revascularization by percutaneous transluminal coronary angioplasty and/or stenting (PCI) on outcome after subsequent coronary artery bypass grafting (CABG).


RESULTS
The ischaemia management with Accupril post-bypass Graft via Inhibition of the coNverting Enzyme (IMAGINE) trial, conducted between November 1999 and September 2004, tested whether early initiation of an angiotensin-converting enzyme inhibitor post-CABG, in stable patients with LVEF >or=40%, would reduce cardiovascular events. Of the 2489 patients included in the IMAGINE trial, undergoing their first operation, 430 had a history of PCI prior to surgery (PCI group), and 2059 were referred to surgery without previous PCI (non-PCI group). There was a significant increase in the primary IMAGINE endpoint in the PCI group, HR = 1.53 [1.17-1.98], P = 0.0016. Coronary revascularization, HR = 1.80 [1.13-2.87], P = 0.014, unstable angina requiring hospitalization, HR = 2.43 [1.52-3.89], P = 0.0002, were the two individual components that significantly increased in the PCI group, even when adjusted for baseline characteristics (age, sex, history of myocardial infarction or stroke, diabetes, treatment group, or off-pump surgery).


CONCLUSIONS
Patients with left ventricular ejection fraction >or=40% having a history of PCI prior to surgery had a worse outcome post-CABG than those with no prior PCI. Further studies are needed to investigate whether these results apply for drug eluting stents.
Chocron
Sidney
S
Department of Cardiac Surgery, Hopital Jean Minjoz, University of Franche-Comté, 25030 Besançon Cedex, France. sidney.chocron@univ-fcomte.fr
Baillot
Richard
R
Rouleau
Jean Lucien
JL
Warnica
Wayne J
WJ
Block
Pierre
P
Johnstone
David
D
Myers
Martin G
MG
Calciu
Cristina Dana
CD
Nozza
Anna
A
Martineau
Pierre
P
van Gilst
Wiek H
WH
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D001026:Coronary Artery Bypass / Q000379:methods*; D003327:Coronary Disease / Q000628:therapy*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000209:etiology*; D011475:Prosthesis Failure; D012086:Reoperation / Q000379:methods; D015607:Stents / Q000009:adverse effects*; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome