Synthesis of indole-3-carboxylic acid derivatives by Pd(0)-catalyzed intramolecular alpha-arylation of beta-(2-iodoanilino) esters.
beta-(2-Iodoanilino) esters undergo intramolecular alpha-arylation in the presence of Pd(PPh(3))(4) and potassium phenoxide. The reaction is a useful methodology for the preparation of indole-3-carboxylic acid ester derivatives.
Solé
Daniel
D
Laboratori de Química Orgànica, Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028-Barcelona, Spain. dsole@ub.edu
Serrano
Olga
O
D000814:Aniline Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D002384:Catalysis; D004952:Esters / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis*; D007462:Iodobenzenes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
D000814:Aniline Compounds; D002264:Carboxylic Acids; D004952:Esters; D007211:Indoles; D007462:Iodobenzenes; D010165:Palladium