Development of two alginate-based wound dressings.
Two types of new alginate-based wound dressings, Type-AP and Type-AE, were fabricated by the EDC-activated crosslinking of alginate with Polyethyleneimine and Ethylenediamine, respectively. As compared with the commercial non-woven wound dressing, Kaltostat, both Type-AP and Type-AE dressings had higher degradation temperature, lower calcium content, and a sponge-like macroporous structure. In addition, these two alginate-based dressings had higher mechanical stress (12.37 +/- 1.72 and 6.87 +/- 0.5 MPa for Type-AP and -AE, respectively) and higher water vapor transmission rates (both about 3,500 g/m2/day) than Kaltostat (0.87 +/- 0.12 MPa and 2,538 g/m2/day). Fibroblasts proliferated faster on these two newly developed wound dressings at a higher rate as compared with that on Kalostat dressing. The results of animal study showed that the wounds treated with either Type-AP or Type-AE dressings healed faster than Kaltostat with less encapsulation of residuals by fibrous tissue and more neo-capillary formation. These two newly developed Type-AP and Type-AE porous wound dressings thus have great potential for clinical applications.
Chiu
Chih-Tung
CT
Institute of Biomedical Engineering, National Yang Ming University, No. 155, Sec. 2, Li-Nung St., Beitou District, Taipei 11221, Taiwan, ROC.
Lee
Jui-Sheng
JS
Chu
Chi-Shung
CS
Chang
Yi-Pin
YP
Wang
Yng-Jiin
YJ
D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001458:Bandages; D005029:Ethylenediamines / Q000737:chemistry; D005347:Fibroblasts / Q000378:metabolism; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D008855:Microscopy, Electron, Scanning; D011094:Polyethyleneimine / Q000737:chemistry; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D014867:Water / Q000737:chemistry; D014945:Wound Healing
D000464:Alginates; D005029:Ethylenediamines; D006603:Hexuronic Acids; D014867:Water; C031234:ethylenediamine; D020723:Glucuronic Acid; D011094:Polyethyleneimine