title: The Claisen rearrangement approach to fused bicyclic medium-ring oxacycles.
abstract: The synthesis of five fused-bicyclic medium-ring lactones carrying identical ring-fusion to that in the polyether toxins is described using an enolate hydroxylation, intramolecular hydrosilation, Claisen rearrangement sequence.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW. johnathan.burton@chem.ox.ac.uk
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Burton
authors.forename: Edward A
authors.initials: EA
authors.lastname: Anderson
authors.forename: Paul T
authors.initials: PT
authors.lastname: O'Sullivan
authors.forename: Ian
authors.initials: I
authors.lastname: Collins
authors.forename: John E
authors.initials: JE
authors.lastname: Davies
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Bond
authors.forename: Neil
authors.initials: N
authors.lastname: Feeder
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Holmes
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006900:Hydroxylation; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones