title: Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters: assessment of different treatments.
abstract: BACKGROUND
  The treatment of multidrug-resistant Acinetobacter baumannii meningitis is a serious therapeutic problem due to the limited penetration of antibiotics into the CSF. We describe the clinical features and the outcome of a group of patients with nosocomial neurosurgical meningitis treated with different therapeutic options.
  
  
  METHODS
  All patients with nosocomial post-surgical meningitis due to A. baumannii diagnosed between 1990 and 2004 were retrospectively reviewed.
  
  
  RESULTS
  During the period of study, 51 cases of this nosocomial infection were identified. Twenty-seven patients were treated with intravenous (iv) monotherapy: carbapenems (21 cases), ampicillin/sulbactam (4 cases) and other antibiotics (2 cases). Four patients were treated with iv combination therapy. Nineteen patients were treated with iv and intrathecal regimens: colistin by both routes (8 cases), carbapenems plus iv and intrathecal (4 cases) or only intrathecal (5 cases) aminoglycosides, and others (2 cases). Seventeen patients died due to the infection. One patient died without treatment. The mean (SD) duration of therapy was 17.4 (8.3) days (range 3-44). Although no patients treated with colistin died, we did not observe statistically significant differences in the mortality among the groups with different treatments.
  
  
  CONCLUSIONS
  Nosocomial Acinetobacter meningitis has a high mortality. Combined therapy with iv and intrathecal colistin is a useful and safe option in the treatment of nosocomial Acinetobacter meningitis.
authors.affiliation: Infectious Diseases Unit, Hospital Central de Asturias, Spain. azucenarodriguez@telecable.es
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez Guardado
authors.forename: A
authors.initials: A
authors.lastname: Blanco
authors.forename: V
authors.initials: V
authors.lastname: Asensi
authors.forename: F
authors.initials: F
authors.lastname: Pérez
authors.forename: J C
authors.initials: JC
authors.lastname: Rial
authors.forename: V
authors.initials: V
authors.lastname: Pintado
authors.forename: E
authors.initials: E
authors.lastname: Bustillo
authors.forename: M
authors.initials: M
authors.lastname: Lantero
authors.forename: E
authors.initials: E
authors.lastname: Tenza
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: J A
authors.initials: JA
authors.lastname: Maradona
authors.forename: J A
authors.initials: JA
authors.lastname: Cartón
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002557:Cerebrospinal Fluid Shunts; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008581:Meningitis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents