Potential basis for amphotericin B resistance in Aspergillus terreus.
This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.
Blum
Gerhard
G
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria.
Perkhofer
Susanne
S
Haas
Hubertus
H
Schrettl
Markus
M
Würzner
Reinhard
R
Dierich
Manfred P
MP
Lass-Flörl
Cornelia
C
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis; D001230:Aspergillus / Q000145:classification* / Q000187:drug effects* / Q000201:enzymology; D002374:Catalase / Q000096:biosynthesis*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D000666:Amphotericin B; D002374:Catalase