title: Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus.
abstract: Silymarin (70 mg/kg) and succinic acid (50 mg/kg) reduce blood glucose and cholesterol concentrations, inhibit LPO, and correct oxidative phosphorylation disturbances in liver mitochondria in experimental diabetes mellitus induced by injection of streptozotocin (65 mg/kg) in rats.
authors.affiliation: Department of Pharmacology, Siberian State Medical University, Tomsk. edu@ssmu.ru
authors.forename: A I
authors.initials: AI
authors.lastname: Vengerovskii
authors.forename: V A
authors.initials: VA
authors.lastname: Khazanov
authors.forename: K A
authors.initials: KA
authors.lastname: Eskina
authors.forename: K Yu
authors.initials: KY
authors.lastname: Vasilyev
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000188:drug therapy; D010085:Oxidative Phosphorylation / Q000187:drug effects; D012838:Silymarin / Q000627:therapeutic use*; D019802:Succinic Acid / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D012838:Silymarin; D002784:Cholesterol; D019802:Succinic Acid