title: [A case of advanced gastric cancer successfully treated by combination therapy of S-1 and docetaxel].
abstract: A 70-year-old man with gastric cancer of Borrmann type 3, liver metastases and peritoneal dissemination was treated by combination therapy of S-1 and docetaxel (DOC). He received DOC intravenously at 40 mg/m(2) on day 1 and S-1 orally at 100 mg/body on day 1 to 14, repeated every 28 days. After 2 courses of treatment, a CT scan revealed improvement of the gastric wall thickness, the eminent decrease of the peritoneal fluid and the reduction of the liver metastasis. After 3 courses of treatment, the primary lesion was remarkably improved on endoscopic examination, and the tumor marker normalized after 4 courses of treatment. Toxicities included leukocytopenia (WHO grade 3), neutropenia ( grade 3), anorexia (grade 2), and nausea (grade 2). Outpatient chemotherapy was possible by reduction of dose (S-1 100--> 80 mg/body, DOC 40--> 32 mg/m2). The response was maintained on CT and endoscopic examination after 21 courses of treatment. A case of an advanced gastric cancer patient successfully treated by combination therapy of S-1 and DOC was reported.
authors.affiliation: Dept. of Internal Medicine, Niigata Cancer Center Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ikarashi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Akiyama
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Motoyama
authors.forename: Syunya
authors.initials: S
authors.lastname: Sasaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ito
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Funakoshi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kato
authors.forename: Futoshi
authors.initials: F
authors.lastname: Arai
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D000077143:Docetaxel; D004338:Drug Combinations; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology*; D043823:Taxoids / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid