Vertical transmission of multidrug-resistant Q151M human immunodeficiency virus type 1 strains.
We report the first case of mother-to-child transmission of human immunodeficiency virus type 1 strains harboring multiple mutations including the Q151M multinucleoside reverse transcriptase inhibitor resistance mutation. Sustained virologic success was obtained in the infant with postnatal antiretroviral therapy optimized according to genotypic drug resistance testing and therapeutic drug monitoring.
Henry
Mireille
M
Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique et d'Hygiène, CHRU Timone, Marseille, France.
Thuret
Isabelle
I
Solas
Caroline
C
Genot
Sèverine
S
Colson
Philippe
P
Tamalet
Catherine
C
D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy
D044966:Anti-Retroviral Agents