title: Frequency of and trends in fragrance allergy over a 15-year period.
abstract: BACKGROUND
  The widespread use of fragrance-containing products is probably the most important reason for its high impact in allergic contact dermatitis.
  
  
  OBJECTIVE
  To describe the frequency of contact allergy to fragrance allergens as tested in the standard series, in relation to age, sex and lesion locations. To determine trends in frequency over the years and to study the association between positive tests observed with the different fragrance-allergy markers as well as between specific fragrance allergens and locations of the lesions.
  
  
  METHODS
  10 128 patients underwent patch testing between January 1990 and December 2005 at the Dermatology department in Leuven.
  
  
  RESULTS
  1463 (14.5%), that is, 380 (26%) males and 1083 (74%) females, reacted positively to at least 1 fragrance-allergy marker in the standard series: 9% to fragrance mix I, 6% to Myroxylon pereirae, and 4.8% to colophonium (often in association), 2.1% to hydroxyisohexyl 3-cyclohexene carboxaldehyde and 2.1% to fragrance mix II, the latter 2 allergens having been introduced more recently. Over the years, fragrance contact allergy has shown a fluctuating trend. Hands and face were the most commonly affected body sites. Moreover, a significant association was found between specific fragrance allergens and certain locations.
  
  
  CONCLUSIONS
  This study illustrates that fragrance contact allergy is common in patients suffering from contact dermatitis.
authors.affiliation: Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Andrea
authors.initials: A
authors.lastname: Nardelli
authors.forename: An
authors.initials: A
authors.lastname: Carbonez
authors.forename: Winfried
authors.initials: W
authors.lastname: Ottoy
authors.forename: Jacques
authors.initials: J
authors.lastname: Drieghe
authors.forename: An
authors.initials: A
authors.lastname: Goossens
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000009:adverse effects*; D001530:Belgium / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D000485:Allergens; D010476:Perfume