title: Central neurocytoma: 9 case series and review.
abstract: BACKGROUND
  Reviewing the literature on central neurocytoma revealed that functional outcomes traditionally have been assessed by KPS. However, KPS is not sufficiently sensitive to assess functional outcomes compared with the Barthel Index and the Functional Independence Measure (the FIM instrument). Discussion of other functional assessments and various aspects of central neurocytomas has never been documented clearly.
  
  
  METHODS
  Nine case series of primary central neurocytomas received total or STR at our hospital. The clinical features, neuroradiologic findings, histopathologic features, and functional outcomes were listed and analyzed. Moreover, the functional outcomes were assessed using KPS, Barthel Index, and FIM instrument. The follow-up period ranged from 8 to 33 months after surgery.
  
  
  RESULTS
  Patients with increased GFAP positivity or MIB-1 index greater than 3% did not have the worst scores in functional assessments. The functional outcomes of the cases presented here, including KPS, Barthel Index, and FIM instrument, were listed in Table 4. Most patients achieved good functional outcomes. The average KPS, Barthel Index, and FIM instrument were 86.25 +/- 14.08 (range, 60-100), 86.88 +/- 17.31 (range, 50-100), and 111 +/- 17.02 (range, 78-126), respectively.
  
  
  CONCLUSIONS
  Most of the patients in this investigation achieved good ability to independently perform daily activity. Whether the high score of functional outcome was correlated with benign tumor course or 5-year survival rate remains uncertain. We recommend regular follow-up for detecting tumor growth or recurrence, although central neurocytomas are always benign.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chang Gung University, Kuei-Shan County, Taoyuan 333, Taiwan, Republic of China.
authors.forename: Chien-Min
authors.initials: CM
authors.lastname: Chen
authors.forename: Kai-Hua
authors.initials: KH
authors.lastname: Chen
authors.forename: Shih-Ming
authors.initials: SM
authors.lastname: Jung
authors.forename: Hung-Chih
authors.initials: HC
authors.lastname: Hsu
authors.forename: Chin-Man
authors.initials: CM
authors.lastname: Wang
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D002533:Cerebral Angiography; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D018306:Neurocytoma / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D019635:Neurosurgical Procedures / Q000379:methods; D011878:Radiotherapy / Q000379:methods; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen