title: Intensive care unit acquired infection and organ failure.
abstract: OBJECTIVE
  To assess the temporal relationship between ICU-acquired infection (IAI) and the prevalence and severity of organ dysfunction or failure (OD/F).
  
  
  METHODS
  Observational, single center study in a mixed intensive care unit of a university hospital.
  
  
  METHODS
  We analyzed 1,191 patients hospitalized for more than 2 days during a 2-year observation period: 845 did not acquire IAI, 306 of whom had infection on admission (IOA); 346 did acquire IAI, 125 of whom had IOA.
  
  
  RESULTS
  The SOFA score was calculated daily, both SOFAmax, the sum of the worst OD/F during the ICU stay, and SOFApreinf, the sum of the worst OD/F existing before the occurrence of the first IAI. The SAPS II and SOFA score of the first 24 h were significantly higher in patients with than in those without IAI. SOFApreinf of IAI patients was also higher than the SOFAmax of patients without IAI both in patients with (12.1+/-4.6 vs. 8.9+/-4.7) and those without IOA (9.2+/-4.0 vs. 6.7+/-3.5). SOFApreinf represented 85.7% of the value of SOFAmax in patients with IAI. SOFApreinf increased significantly with the occurrence of sepsis, severe sepsis, or septic shock during ICU stay. Severe sepsis and septic shock during ICU stay as well as SOFApreinf were part of the factors associated with hospital mortality.
  
  
  CONCLUSIONS
  IAI is significantly associated with hospital mortality; however, its contribution to OD/F is minor. Moreover, severity of IAI seems to be related to previous health status.
authors.affiliation: Department of General Intensive Care, University Hospital Center, University of Liege, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium. pdamas@chu.ulg.ac.be
authors.forename: Pierre
authors.initials: P
authors.lastname: Damas
authors.forename: Didier
authors.initials: D
authors.lastname: Ledoux
authors.forename: Monique
authors.initials: M
authors.lastname: Nys
authors.forename: Mehran
authors.initials: M
authors.lastname: Monchi
authors.forename: Patricia
authors.initials: P
authors.lastname: Wiesen
authors.forename: Benoît
authors.initials: B
authors.lastname: Beauve
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Preiser
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium / Q000453:epidemiology; D003428:Cross Infection / Q000150:complications* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D015999:Multivariate Analysis; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D012720:Severity of Illness Index