Activity of daptomycin against Listeria monocytogenes isolates from cerebrospinal fluid.
We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC(90)) was 4.0 mg/liter. For the Etest method, the MIC range was 1.0 to 4.0 and the MIC(90) was 4.0 mg/liter. Presently, daptomycin cannot be recommended for the treatment of L. monocytogenes meningitis.
Spanjaard
Lodewijk
L
Department of Medical Microbiology, L1-243, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. L.Spanjaard@amc.uva.nl
Vandenbroucke-Grauls
Christina M J E
CM
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017576:Daptomycin / Q000494:pharmacology*; D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000302:isolation & purification; D008088:Listeriosis / Q000134:cerebrospinal fluid* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009426:Netherlands
D000900:Anti-Bacterial Agents; D017576:Daptomycin