Association between interleukin-6 promoter haplotypes and aggressive periodontitis.
BACKGROUND
Interleukin-6 (IL-6) polymorphisms have been shown to affect IL-6 promoter activity. This study investigated the possible role of IL-6 genetic polymorphisms and haplotypes in the predisposition to aggressive periodontitis (AgP).


METHODS
A case-control association study on 224 AgP patients and 231 healthy controls was performed in order to detect differences in genotype distributions of five single nucleotide polymorphisms (SNPs) located in the promoter region of the IL-6 gene.


RESULTS
The IL-6 -1363 polymorphism was associated with a diagnosis of AgP in subjects of all ethnicities (p=0.006, adjusted logistic regression). The -1480 SNP was associated with LAgP in subjects of all ethnicities (p=0.003). The -1480 and -6106 polymorphisms were associated with Localized AgP in Caucasians (n=24) (p=0.007 and 0.010, respectively). Haplotypes determined by the -1363 and -1480 polymorphisms were also associated with LAgP (p=0.001) in Caucasians.


CONCLUSIONS
This study supports the hypothesis of a link between IL-6 genetic factors and AgP and highlights the importance of two IL-6 polymorphisms (-1363 and -1480) in modulating disease phenotype and susceptibility.
Nibali
Luigi
L
Periodontology Unit, University College London, London, UK. l.nibali@eastman.ucl.ac.uk
Griffiths
Gareth S
GS
Donos
Nikos
N
Parkar
Mohamed
M
D'Aiuto
Francesco
F
Tonetti
Maurizio S
MS
Brett
Peter M
PM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011859:Radiography
D015850:Interleukin-6