title: Multiple aggressive squamous skin cancers in association with nonbullous congenital ichthyosiform erythroderma.
abstract: Nonbullous congenital ichthyosiform erythroderma (NBCIE) is one of the autosomal recessive inherited non-syndromic ichthyoses and is currently diagnosed on clinical grounds alone. Skin cancer is not a recognized complication of NBCIE. We report here two NBCIE patients who have developed multiple aggressive nonmelanoma skin cancers, predominantly cutaneous squamous cell carcinoma. NBCIE may be a risk factor for skin cancer development.
authors.affiliation: Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK. vbrown@doctors.org.uk
authors.forename: V L
authors.initials: VL
authors.lastname: Brown
authors.forename: P B J
authors.initials: PB
authors.lastname: Farrant
authors.forename: R J
authors.initials: RJ
authors.lastname: Turner
authors.forename: M L
authors.initials: ML
authors.lastname: Price
authors.forename: S M
authors.initials: SM
authors.lastname: Burge
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*