title: Pancreatic changes in patients with primary sclerosing cholangitis: MR cholangiopancreatography and MRI findings.
abstract: OBJECTIVE
  To evaluate the possible pancreatic changes and their frequencies in patients with primary sclerosing cholangitis (PSC) on MR cholangiopancreatography (MRCP), and conventional abdominal MRI.
  
  
  METHODS
  Patient group consisted of 29 PSC (13 male, 16 female) cases, whereas cohort 1 consisted of 12 female patients with primary biliary cirrhosis, and cohort 2 consisted of 17 patients (6 male, 11 female) with non-immune chronic liver disease. Two radiologists retrospectively evaluated the MR examinations paying special attention to the pancreatic size (atrophy or enlargement), T1- and T2-signal intensity of the pancreas, focal pancreatic lesion, capsule-like rim, peripancreatic edema or fluid, fascial thickening, and pancreatic ducts (dilatation or narrowing). The results are expressed as percentages. Three groups were compared using Pearson chi-square test for each feature. However, only p-value for "dilatation of the pancreatic duct" was determined, whereas p-value could not be calculated because of the insufficient number of subjects/sequences for the other features.
  
  
  RESULTS
  Twelve PSC patients (41.3%) had pancreatic abnormalities. The most common pancreatic changes in PSC patients were decreased T1-signal intensity (44%) and dilatation of the pancreatic duct (13.8%), respectively. Increased T2-signal intensity was also shown in 2 PSC patients (6.9%).
  
  
  CONCLUSIONS
  Even PSC patients without any sign of pancreatitis, can show MR changes in the pancreatic parenchyma or the pancreatic duct. The etiologies of these changes, and whether they are unique to PSC, are still controversial. Histopathological studies bringing light to these pancreatic changes are needed.
authors.affiliation: Ankara University School of Medicine, Department of Radiology, Ankara Universitesi Tip Fakültesi, Cebeci Hastanesi, Cebeci, Ankara 06100, Turkey. eozkavukcu@gmail.com
authors.forename: Esra
authors.initials: E
authors.lastname: Ozkavukcu
authors.forename: Ayşe
authors.initials: A
authors.lastname: Erden
authors.forename: Ilhan
authors.initials: I
authors.lastname: Erden
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000209:etiology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity