Primary synovial sarcoma arising in the parotid region diagnosed by fluorescence in situ hybridization.
Synovial sarcomas account for 5% of pediatric soft tissue sarcomas, and primarily arise in the extremities. We report a case of synovial sarcoma in the parotid region. A 29-year-old woman presented with a 3-year history of a slow-growing, slight painful swelling in the preauricular region. The patient underwent right deep parotidectomy preserved with facial nerve. In immunohistochemistry, the epithelial cells were positive for cytokeratin AE1/3 and epithelial membrane antigen. The stromal cells were immunoreactive for vimentin and BCL2. The both types of cells were positive for CD99. The SYT-SSX fusion gene from chromosomal translocation was detected by fluorescence in situ hybridization in this case.
Kawata
Ryo
R
Department of Otolaryngology, Osaka Medical College, 2-7 Daigaku-Cho Takatsuki, Osaka 569-8686, Japan. oto034@poh.osaka-med.ac.jp
Terada
Tetsuya
T
Takenaka
Hiroshi
H
Kurisu
Yoshitaka
Y
Tsuji
Motomu
M
D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D010306:Parotid Gland / Q000473:pathology / Q000601:surgery; D010307:Parotid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D011518:Proto-Oncogene Proteins / Q000235:genetics; D018714:Radiotherapy, Adjuvant; D012097:Repressor Proteins / Q000235:genetics; D013584:Sarcoma, Synovial / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C093961:SS18 protein, human