Glucose reverses fasting-induced activation in the arcuate nucleus of mice.
The hypothalamic arcuate nucleus is an important target for metabolic and hormonal signals controlling food intake. As demonstrated by c-Fos studies, arcuate neurons are activated in food-deprived mice, whereas refeeding reverses the fasting-induced activation. To evaluate whether an increase in blood glucose has an inhibitory effect on these neurons, we analyzed the c-Fos response to an intraperitoneal glucose injection in fasted mice. This treatment increased blood glucose levels twofold and reduced 2-h food intake. Similar to refeeding, it also reversed the fasting-induced activation in the arcuate nucleus. Therefore, an increase in blood glucose might be an important feeding-related signal acting via the arcuate nucleus to oppose orexigenic stimuli.
Becskei
Csilla
C
Institute of Veterinary Physiology and Zurich Centre of Integrative Human Physiology, University of Zurich, Zurich, Switzerland. csillab@vetphys.uzh.ch
Lutz
Thomas A
TA
Riediger
Thomas
T
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects*; D001522:Behavior, Animal; D001786:Blood Glucose / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005215:Fasting / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D013549:Sweetening Agents / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D016760:Proto-Oncogene Proteins c-fos; D013549:Sweetening Agents; D005947:Glucose