Deep brain stimulation in the globus pallidus to treat dystonia: electrophysiological characteristics and 2 years' follow-up in 10 patients.
Deep brain stimulation (DBS) was applied in the internal segment of the globus pallidus (GPi) to treat dystonia in 10 patients. One year after surgery the Burke-Fahn-Marsden movement scores were significantly lower than preoperative values (P=0.01). Two years after surgery the mean decrease reached 65% (P=0.001) with no motor symptoms worsening. Single unity activity was recorded in the operating room: GPi cells discharged with tonic (n=19; 29%), irregular (n=32; 48%), or burst-like activity (n=15; 23%) and fired with a mean discharge rate of 39 Hz+/-22. Some neurons demonstrated an oscillatory activity with periods lasting several seconds. Pairs of pallidal cells (n=8) recorded simultaneously displayed discharge synchronization. Movement modulated 64.4% of the cells tested, with increases in firing in 89% of cells and decreases in firing in 10% of cells. GPi cells responded to flexion and extension movements and to several passive manipulations indicating an important sensory role in dystonia. GPi neurons fired in advance of the electromyography (EMG) when the surface EMG was recorded simultaneously with the neuronal activity. Spectral analysis of the co-contracting muscles during dystonia demonstrated prominent high peaks at a low frequency band (20 Hz) during involuntary and voluntary movements. The high amplitude EMG profile recorded at rest diminished to very low values with GPi stimulation, allowing an ease of voluntary contractions. We conclude that DBS in the GPi is a reliable surgical technique for dystonia. GPi cells discharge with distinct electrophysiological characteristics that may explain some of the symptoms in dystonia. EMG recording in the operating room helps to determine which DBS contacts produce the best benefit.
Magariños-Ascone
C M
CM
Servicio de Neurología Experimental, Departamento Investigación, Hospital Ramón y Cajal, Madrid, 28034, Spain. carlos.magarinos@hrc.es
Regidor
I
I
Gómez-Galán
M
M
Cabañes-Martínez
L
L
Figueiras-Méndez
R
R
D000200:Action Potentials / Q000528:radiation effects*; D000293:Adolescent; D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D004185:Disability Evaluation; D004307:Dose-Response Relationship, Radiation; D004421:Dystonia / Q000503:physiopathology* / Q000628:therapy*; D004567:Electrodes, Implanted; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000528:radiation effects; D009119:Muscle Contraction / Q000502:physiology / Q000528:radiation effects; D018482:Muscle, Skeletal / Q000503:physiopathology; D009474:Neurons / Q000145:classification / Q000502:physiology; D013997:Time Factors