Hypocretin-1 and secondary signs in Huntington's disease.
Huntington's disease is characterised by unwanted movements, psychiatric disturbances and cognitive decline. Less well recognised symptoms and signs are weight loss, autonomic dysfunction and sleep disorders. In this study we focus on hypocretin-1 and hypothalamus functions. We found a reduction by about 30% in hypocretin signalling in patients with HD. However, it remains unclear whether this moderate decrease in hypocretin signalling contributes to clinical symptoms.
Roos
R A C
RA
Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands. r.a.c.roos@lumc.nl
Aziz
N A
NA
D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D000068797:Orexins; D015398:Signal Transduction
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins