title: Outcome of lupus nephritis in Iranian children: prognostic significance of certain features.
abstract: The objective of this study was to determine the clinical and histopathological features and outcome of children with lupus nephritis (LN). Of 84 children with systemic lupus erythematosus (SLE), we retrospectively studied 58 children (69%) under 15 years of age with biopsy-proven LN who had been followed between October 1989 and January 2005. The mean age at diagnosis or initial referral was 10.6 +/- 2.25 years, and the mean follow-up was 5.3 +/- 4.1 years. Class IV LN was observed in 34 (58.6%) patients. The 5-year patient and renal survival rates were 82.5 and 78.5%, respectively, in the total group, and 75 and 85.8%, respectively, in patients with Class IV LN. No independent predictor of unfavorable outcome, including renal histology, was detected by multivariate analysis. The mid-term patient and the renal survival rates of Iranian children with biopsy-proven LN are high. Within 5 years of follow-up, renal histology was not a predictor for survival.
authors.affiliation: Department of Pediatric Nephrology, The Children's Hospital Medical Center, School of Medicine, Medical Sciences/University of Tehran, Dr. Gharib St. Azadi Avenue, Tehran, Iran. ataiinem@sina.tums.ac.ir
authors.forename: Neamatollah
authors.initials: N
authors.lastname: Ataei
authors.forename: Manijeh
authors.initials: M
authors.lastname: Haydarpour
authors.forename: Abbas
authors.initials: A
authors.lastname: Madani
authors.forename: Seyed Taher
authors.initials: ST
authors.lastname: Esfahani
authors.forename: Niloufar
authors.initials: N
authors.lastname: Hajizadeh
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Moradinejad
authors.forename: Taghi
authors.initials: T
authors.lastname: Gholmohammadi
authors.forename: Shahriar
authors.initials: S
authors.lastname: Arbabi
authors.forename: Marzieh
authors.initials: M
authors.lastname: Haddadi
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007492:Iran / Q000453:epidemiology; D007668:Kidney / Q000473:pathology*; D008181:Lupus Nephritis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents