title: Chromosomal changes induced in mouse bone marrow cells following six weeks inhalation of cyclohexanol.
abstract: The effects of low doses of cyclohexanol exposure were studied in mouse bone marrow cells including chromosome aberrations (CA), micronucleus (MN) and sister chromatid exchanges (SCE) as biomarkers. Capillaries with a tested agent that was evaporated continuously were placed in an experimental chamber for six weeks. No clastogenic and/or aneugenic effect of CA and MN induction was observed. A significant elevation of induced damage was achieved in the SCE study (p < 0.001) that has confirmed the early exposure of cyclohexanol to mice.
authors.affiliation: Institute of Genetics, University of Veterinary Medicine, Komenského 73, 041 81 Kosice, Slovak Republic. sivikova@uvm.sk
authors.forename: Katarína
authors.initials: K
authors.lastname: Siviková
authors.forename: J
authors.initials: J
authors.lastname: Dianovský
authors.forename: Elena
authors.initials: E
authors.lastname: Piesová
authors.forename: Beatá
authors.initials: B
authors.lastname: Holecková
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced*; D003511:Cyclohexanols / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D003511:Cyclohexanols