Models and signal processing for an implanted ethanol bio-sensor.
The understanding of drinking patterns leading to alcoholism has been hindered by an inability to unobtrusively measure ethanol consumption over periods of weeks to months in the community environment. An implantable ethanol sensor is under development using microelectromechanical systems technology. For safety and user acceptability issues, the sensor will be implanted subcutaneously and, therefore, measure peripheral-tissue ethanol concentration. Determining ethanol consumption and kinetics in other compartments from the time course of peripheral-tissue ethanol concentration requires sophisticated signal processing based on detailed descriptions of the relevant physiology. A statistical signal processing system based on detailed models of the physiology and using extended Kalman filtering and dynamic programming tools is described which can estimate the time series of ethanol concentration in blood, liver, and peripheral tissue and the time series of ethanol consumption based on peripheral-tissue ethanol concentration measurements.
Han
Jae-Joon
JJ
School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA. jhan@purdue.edu
Doerschuk
Peter C
PC
Gelfand
Saul B
SB
O'Connor
Sean J
SJ
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D000431:Ethanol / Q000032:analysis / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000502:physiology*; D008954:Models, Biological; D019736:Prostheses and Implants; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
D000431:Ethanol