[Levels of interleukin-1beta and tumor necrosis factor-alpha in patients with aggressive periodontitis].
OBJECTIVE
To compare the levels of plasma IL-1beta,TNFalpha in aggressive periodontitis (AgP) patients and periodontally healthy subjects.


METHODS
Venous blood samples were collected from 56 AgP patients and 39 periodontally healthy controls. Clinical examination consisted of bleeding index (BI), probing depth(PD)attachment loss measurements (AL) and percentage of severe sites. Plasma levels of IL-1beta and TNF-alpha were determined using a high-sensitivity ELISA assay.


RESULTS
The concentrations of IL-1beta in AgP patients were significantly higher than those in healthy controls (7.23 ng/L vs 3.52 ng/L, P=0.003), which were positively correlated with BI, PD, AL and the percentage of severe sites (r=0.170, P=0.038; r=0.175, P=0.033; r=0.168, P=0.040; r=0.236, P=0.004). The difference between the levels of TNF-alpha in AgP patients and healthy controls was not observed (1.07 ng/L vs 1.06 ng/L, P=0.437). No correlations between the plasma level of TNF-alpha and the periodontal parameters were detected (r=0.023, P=0.808; r=0.025, P=0.782; r=0.075, P=0.407; r=0.049, P=0.586).


CONCLUSIONS
AgP may have impact on the elevation of plasma level of IL-1beta, while no association between AgP and plasma level of TNF-alpha was found.
Sun
Xiao-Jun
XJ
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Meng
Huan-Xin
HX
Chen
Zhi-Bin
ZB
D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D010949:Plasma / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha