Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production.
Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.
Flores-Mendoza
Lilian
L
Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a la Victoria, Km. 0.6., Hermosillo, Sonora, México.
Silva-Campa
Erika
E
Reséndiz
Mónica
M
Osorio
Fernando A
FA
Hernández
Jesús
J
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D018122:B7-1 Antigen / Q000096:biosynthesis / Q000276:immunology; D051940:B7-2 Antigen / Q000096:biosynthesis / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000276:immunology; D008213:Lymphocyte Activation; D019318:Porcine Reproductive and Respiratory Syndrome / Q000276:immunology* / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology*; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology; D015854:Up-Regulation
D018122:B7-1 Antigen; D051940:B7-2 Antigen; D000949:Histocompatibility Antigens Class II; D016753:Interleukin-10