Glutamate/aspartate supplementation during cardiopulmonary bypass: effect on postoperative neurocognitive function.
In this randomized trial, we investigated the effect of glutamate/aspartate-containing cardioplegia on neurocognitive function in 70 patients undergoing first-time elective coronary artery bypass graft surgery. Half of the patients received glutamate/aspartate, and the other 35 patients served as controls and received crystalloid cardioplegia. Neurocognitive function after surgery was assessed with the Mini-Mental State Examination performed before surgery and again on postoperative day 3. Although patients in both groups scored slightly lower postoperatively (17 versus 18 of a total of 30 points), no significant group differences were found. Our results indicate that glutamate/aspartate supplementation had no impact on neurocognitive function after coronary artery bypass graft surgery.
Erol
Demet Dogan
DD
Department of Anesthesiology and Reanimation, Kocatepe University School of Medicine, Afyonkarahisar, Turkey. demetdoganerol@mynet.com
Ibis
Halil Arif
HA
D000368:Aged; D001224:Aspartic Acid / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D003071:Cognition; D003072:Cognition Disorders / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D018698:Glutamic Acid / Q000008:administration & dosage*; D006305:Health Status Indicators; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D049590:Postpartum Period; D011581:Psychological Tests; D011594:Psychometrics; D012307:Risk Factors
D001224:Aspartic Acid; D018698:Glutamic Acid