Connections of cat auditory cortex: I. Thalamocortical system.
Despite the functional importance of the medial geniculate body (MGB) in normal hearing, many aspects of its projections to auditory cortex are unknown. We analyzed the MGB projections to 13 auditory areas in the cat using two retrograde tracers to investigate thalamocortical nuclear origins, topography, convergence, and divergence. MGB divisions and auditory cortex areas were defined independently of the connectional results using architectonic, histochemical, and immunocytochemical criteria. Each auditory cortex area received a unique pattern of input from several MGB nuclei, and these patterns of input identify four groups of cortical areas distinguished by their putative functional affiliations: tonotopic, nontonotopic, multisensory, and limbic. Each family of areas received projections from a functionally related set of MGB nuclei; some nuclei project to only a few areas (e.g., the MGB ventral division to tonotopic areas), and others project to all areas (e.g., the medial division input to every auditory cortical area and to other regions). Projections to tonotopic areas had fewer nuclear origins than those to multisensory or limbic-affiliated fields. All projections were organized topographically, even those from nontonotopic nuclei. The few divergent neurons (mean: 2%) are consistent with a model of multiple segregated streams ascending to auditory cortex. The expanded cortical representation of MGB auditory, multisensory, and limbic affiliated streams appears to be a primary facet of forebrain auditory function. The emergence of several auditory cortex representations of characteristic frequency may be a functional multiplication of the more limited maps in the MGB. This expansion suggests emergent cortical roles consistent with the divergence of thalamocortical connections.
Lee
Charles C
CC
Division of Neurobiology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3200, USA. clee@bsd.uchicago.edu
Winer
Jeffery A
JA
D000818:Animals; D001303:Auditory Cortex / Q000033:anatomy & histology* / Q000502:physiology; D001306:Auditory Pathways / Q000033:anatomy & histology / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D001369:Axons / Q000502:physiology / Q000648:ultrastructure*; D001931:Brain Mapping; D002415:Cats; D002772:Cholera Toxin; D005260:Female; D005829:Geniculate Bodies / Q000033:anatomy & histology* / Q000502:physiology; D019044:Image Cytometry; D007150:Immunohistochemistry; D016900:Neurofilament Proteins / Q000032:analysis / Q000378:metabolism; D010897:Pitch Discrimination / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology / Q000648:ultrastructure; D013194:Staining and Labeling; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
D016900:Neurofilament Proteins; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; C062844:wheat germ agglutinin-apohorseradish peroxidase conjugate gold complex; C051774:neurofilament protein H; D002772:Cholera Toxin