Breaking the code of polyadenylation-induced translation.
The translation of many maternal mRNAs is regulated by dynamic changes in poly(A) tail length. During maturation of Xenopus oocytes, polyadenylation is mediated by three different cis elements in the 3' untranslated region (UTR) of maternal mRNAs. In this issue, Piqué et al. (2008) explore the interplay of these elements to elucidate a combinatorial code that predicts the timing of polyadenylation and translation of maternal mRNAs.
Richter
Joel D
JD
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
D000818:Animals; D008954:Models, Biological; D009865:Oocytes / Q000378:metabolism; D026723:Polyadenylation; D014176:Protein Biosynthesis; D039104:RNA 3' Polyadenylation Signals; D012333:RNA, Messenger / Q000378:metabolism*; D014982:Xenopus laevis; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism
D012333:RNA, Messenger; D039221:mRNA Cleavage and Polyadenylation Factors