title: Design of iron oxide/silica/alginate hybrid magnetic carriers (HYMAC).
abstract: A large number of natural and synthetic polymers have already been evaluated for the design of nanomaterials incorporating magnetic nanoparticles for biomedical applications. The possibility to use hybrid (bio)-organic/inorganic nano-carriers have been much less studied. Here we describe the design of Hybrid MAgnetic Carriers (HYMAC) consisting of alginate/silica nanocomposites incorporating magnetite nanoparticles, based on a spray-drying approach. Transmission electron microscopy and X-ray energy dispersive spectrometry confirm the successful incorporation of magnetic colloids within homogeneous hybrid capsules. X-ray diffraction data suggest that surface iron ions are partially desorbed by the spray-drying process, leading to the formation of lepidocrocite and of an iron silicate phase. Magnetic measurements show that the resulting nanocomposites exhibit a superparamagnetic behaviour with a blocking temperature close to 225 K. Comparison with un-silicified capsules indicate that the mineral phase enhances the thermal stability of the polymer network and do not modify of the amount of incorporated iron oxide nanoparticles. Moreover, evaluation of nanocomposite up-take by fibroblasts indicates their possible internalization. A selective intracellular alginate degradation is observed, suggesting that these HYMAC nanomaterials may exhibit interesting properties for the design of drug delivery devices.
authors.affiliation: Chimie de la Matière Condensée de Paris, UMR CNRS 7574, Université Pierre et Marie Curie, 75252 Paris cedex 05, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Boissière
authors.forename: Joachim
authors.initials: J
authors.lastname: Allouche
authors.forename: Roberta
authors.initials: R
authors.lastname: Brayner
authors.forename: Corinne
authors.initials: C
authors.lastname: Chanéac
authors.forename: Jacques
authors.initials: J
authors.lastname: Livage
authors.forename: Thibaud
authors.initials: T
authors.lastname: Coradin
mesh_terms: D000464:Alginates / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008280:Magnetics; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000464:Alginates; D005290:Ferric Compounds; D006603:Hexuronic Acids; C000499:ferric oxide; D012822:Silicon Dioxide; D020723:Glucuronic Acid