title: Effect of Siraitia grosvenorii polysaccharide on glucose and lipid of diabetic rabbits induced by feeding high fat/high sucrose chow.
abstract: The Siraitia grosvenorii polysaccharide (SGP) from the Siraitia grosvenorii (Swingle) was isolated and purified. The therapeutic effects of SGP on diabetic rabbits induced by feeding high fat/high sucrose chow were studied. After administration of SGP for 4 weeks, the fasting blood glucose (FBG), plasma insulin levels (INS), plasma total cholesterol (TC), triglyceride (TG), and HDL-C were assayed. The results showed that administration of SGP can significantly decrease plasma total cholesterol, triglyceride, and glucose levels; and increase HDL-C levels after 4 weeks of treatment. The antihyperglycaemic effect of SGP at dose of 100 mg.kg(-1) bw was the most significant in three dosage groups. Furthermore, SGP could restore the blood lipid levels of diabetic rabbits (P<.05). These data indicate that SGP not only ameliorates the lipid disorder, but also lowers plasma glucose levels. So SGP have obvious glucose-lowering effect on hyperglycaemic rabbits induced by feeding high fat/high sucrose chow, its mechanism may be related to amelioration of lipid metabolism and restoring the blood lipid levels of hyperglycaemic rabbits.
authors.affiliation: School of Life Science and Technology, University of South China, Hengyang 421001, Hunan, China. linguo098@yahoo.com
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Lin
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Hu
authors.forename: Xin-Hui
authors.initials: XH
authors.lastname: Qiao
authors.forename: Qin-Hui
authors.initials: QH
authors.lastname: Tuo
mesh_terms: D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D019662:Cucurbitaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000188:drug therapy*; D004041:Dietary Fats / Q000009:adverse effects*; D008055:Lipids / Q000097:blood*; D011134:Polysaccharides / Q000494:pharmacology*; D011817:Rabbits; D013395:Sucrose / Q000009:adverse effects*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D008055:Lipids; D011134:Polysaccharides; D013395:Sucrose