Bending membranes on demand: fluid phospholipid bilayers on topographically deformable substrates.
We combine hierarchical surface wrinkling of elastomers with lipid membrane deposition techniques to dynamically template complex three-dimensional topographies onto supported lipid bilayers. The real-time introduction of corresponding nano- to micrometer scale curvatures triggers spatially periodic, elastic bending of the bilayer, accompanied by molecular-level reorganizations. This ability to dynamically impose curvatures on supported bilayers and the ensuing re-equilibration promises fundamental material and biophysical investigations of curvature-dependent, static heterogeneities and dynamic reorganizations pervasive in biological membranes.
Sanii
Babak
B
Department of Applied Science and, Biophysics Graduate Group, University of California, Davis, California 95616, USA.
Smith
Andreia Michelle
AM
Butti
Ravichandra
R
Brozell
Adrian M
AM
Parikh
Atul N
AN
D008051:Lipid Bilayers / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D010743:Phospholipids / Q000737:chemistry*; D013499:Surface Properties
D008051:Lipid Bilayers; D010743:Phospholipids