Pallbearer and friends: lending a hand in apoptotic cell clearance.
Engulfment and prompt removal of apoptotic cells occurs from embryogenesis throughout the lifespan of multicellular organisms. A new player, Pallbearer, has recently been identified in Drosophila as being important for efficient engulfment by macrophages. Pallbearer is a component of the SCF E3 ubiquitin ligase complex involved in the ubiquitylation of proteins targeted for proteasomal degradation. This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently.
Elliott
Michael R
MR
Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.
Ravichandran
Kodi S
KS
D000818:Animals; D017209:Apoptosis; D029721:Drosophila Proteins / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000201:enzymology / Q000378:metabolism*; D010587:Phagocytosis; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism*; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism*
D029721:Drosophila Proteins; D025801:Ubiquitin; D044843:SKP Cullin F-Box Protein Ligases; D046988:Proteasome Endopeptidase Complex