Follow-up of cardiovascular adverse events after smallpox vaccination among civilians in the United States, 2003.
Limited information exists regarding intermediate or long-term consequences of cardiac adverse events (CAEs) after smallpox vaccination. We conducted follow up at 5-12 months after vaccination of 203 US civilian vaccinees who reported a possible CAE. Among 31 of the 33 with confirmed CAEs, at least 1 health-related quality-of-life change persisted for approximately 48%; approximately 87% missed work (average, 11.5 days). Among 168 of the 170 case patients with other reported cardiovascular conditions, at least 1 health-related quality-of-life change persisted for approximately 40%; almost 49% missed work (average, 10.2 days). Almost all vaccinees with possible CAEs were working the same number of hours at follow-up compared with before vaccination. Although intermediate-term consequences among possible postvaccination CAEs were not considered serious, lost days of work and a decline in health-related quality of life at the time of follow-up were common, resulting in personal economic and quality-of-life burden.
Sniadack
Mercedes M
MM
National Immunization Program, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Neff
Linda J
LJ
Swerdlow
David L
DL
Schieber
Richard A
RA
McCauley
Mary M
MM
Mootrey
Gina T
GT
D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006282:Health Personnel; D006331:Heart Diseases / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D032541:Mass Vaccination / Q000009:adverse effects*; D008875:Middle Aged; D011788:Quality of Life; D018571:Sentinel Surveillance; D012900:Smallpox Vaccine / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology
C078786:DryVax vaccine; D012900:Smallpox Vaccine