title: The composition of the inflammatory infiltrate in three cases of polyneuritis equi.
abstract: Polyneuritis equi (PNE) is a rare neurological disease in the horse. Because of the suspicion in PNE of a T-lymphocyte mediated immune response against the myelin, the objective of this study was to determine the composition of the inflammatory infiltrate in the involved nerves of 3 horses with PNE, studied retrospectively. T-lymphocytes were demonstrated in the lesions, which suggests a T-lymphocyte mediated immune response against myelin. In addition, the presence of B-lymphocytes indicated a local production of antibodies. More research, involving a prospective study, is needed to determine whether the T-lymphocytes are cytotoxic or T-helper lymphocytes.
authors.affiliation: Department of Clinical Science, Equine Section, Faculty of Veterinary Medicine, University of Liege, Boulevard de Colonster 20, B41 Liege, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: van Galen
authors.forename: D
authors.initials: D
authors.lastname: Cassart
authors.forename: C
authors.initials: C
authors.lastname: Sandersen
authors.forename: C
authors.initials: C
authors.lastname: Delguste
authors.forename: H
authors.initials: H
authors.lastname: Nollet
authors.forename: H
authors.initials: H
authors.lastname: Amory
authors.forename: R
authors.initials: R
authors.lastname: Ducatelle
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002420:Cauda Equina; D005260:Female; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000662:veterinary*; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology*