title: Autosomal dominant polycystic kidney disease is not a risk factor for post-transplant diabetes mellitus. Matched-pair design multicenter study.
abstract: BACKGROUND
  Post-transplant diabetes mellitus (PTDM) is a relatively common complication of kidney transplantation. The aim of our work was to compare the incidence of PTDM in kidney transplant recipients with and without autosomal dominant polycystic kidney disease (ADPKD) in a matched-pair design study.
  
  
  METHODS
  In total, 98 pairs of graft recipients, all of Caucasian origin and who received a kidney from the same cadaveric donor, were included in the study. The following clinical data were collected for statistical analysis: age, body mass index (BMI) before transplant, length and type of dialysis treatment, residual diuresis, and cold and warm graft ischemia time. Diabetes was diagnosed based on American Diabetes Association (ADA) criteria.
  
  
  RESULTS
  Incidence of PTDM was 19.4% in the ADPKD group and 18.4% in the non-ADPKD group, with no significant differences between groups. Multivariate logistic regression analysis of the PTDM risk in the ADPKD group including age, gender, BMI, and dialysis time as independent variables indicated that only higher residual diuresis is a significant independent risk factor (OR = 5.64 per every L/24 h, 95% CI = 1.31-24.33, p = 0.017). Similarly, logistic regression analysis adjusted for age and gender in the non-ADPKD group has shown that significant independent risk factors are BMI (OR = 1.30 per every kg/m(2), 95% CI = 1.06-1.59, p = 0.0094), longer dialysis time prior to transplant (OR = 1.036 per each month, 95% CI = 1.004-1.070, p = 0.025), and a history of arterial hypertension (OR = 9.09, 95% CI = 1.20-68.66, p = 0.030).
  
  
  CONCLUSIONS
  In this paired analysis, our results suggest that diagnosis of ADPKD does not increase risk of PTDM.
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Pietrzak-Nowacka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Jacek
authors.initials: J
authors.lastname: Rózański
authors.forename: Alicja
authors.initials: A
authors.lastname: Debska-Slizień
authors.forename: Leszek
authors.initials: L
authors.lastname: Domański
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dziewanowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Głyda
authors.forename: Magdalena
authors.initials: M
authors.lastname: Jankowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Noceń
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pabisiak
authors.forename: Bolesław
authors.initials: B
authors.lastname: Rutkowski
authors.forename: Magda
authors.initials: M
authors.lastname: Wiśniewska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology; D012307:Risk Factors