title: Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders.
abstract: OBJECTIVE
  We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders.
  
  
  METHODS
  Genetic association study of quantitative lipoprotein traits.
  
  
  METHODS
  In a sample of 1,310 adult Greenlanders, fasting plasma lipid, lipoprotein and apolipoprotein (apo) concentrations were assessed for association with known functional genomic variants of APOC3, APOA5, APOE and PON1. For significantly associated polymorphisms, between-genotype differences were examined in closer detail.
  
  
  RESULTS
  We found that (1) the APOE restriction isotype was associated with variation in plasma total and LDL cholesterol and apo B (all p < .0001); (2) the APOC3 promoter genotype was associated with variation in plasma triglycerides, HDL cholesterol and apo A-I (all p < .002); (3) the APOA5 codon 19 genotype was associated with variation in plasma triglycerides (p = .027); and (4) the PON1 codon 192 genotype was associated with variation in total and LDL cholesterol and apo B (all p < .05).
  
  
  CONCLUSIONS
  Taken together, our results suggest that common genetic variations in APOC3, APOA5, APOE and PON1 are associated with significant variation in intermediate traits in plasma lipoprotein metabolism in Greenlanders; the associations are similar to those observed for these variants in other populations.
authors.affiliation: Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada.
authors.forename: Piya
authors.initials: P
authors.lastname: Lahiry
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Ban
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Pollex
authors.forename: Ross D
authors.initials: RD
authors.lastname: Feldman
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Sawyez
authors.forename: Murray W
authors.initials: MW
authors.lastname: Huff
authors.forename: T Kue
authors.initials: TK
authors.lastname: Young
authors.forename: Peter
authors.initials: P
authors.lastname: Bjerregaard
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hegele
mesh_terms: D000328:Adult; D000367:Age Factors; D053305:Apolipoprotein C-III / Q000235:genetics*; D001054:Apolipoproteins A / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006116:Greenland; D006801:Humans; D004930:Inuit; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
chemical_list: D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D001057:Apolipoproteins E; D008074:Lipoproteins; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human