Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier.
Acute pancreatitis (AP) is a common acute abdomen in clinic with a rapid onset and dangerous pathogenetic condition. AP can cause an injury of intestinal mucosa barrier, leading to translocation of bacteria or endotoxin through multiple routes, bacterial translocation (BT), gut-origin endotoxaemia, and secondary infection of pancreatic tissue, and then cause systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS), which are important factors influencing AP's severity and mortality. Meanwhile, the injury of intestinal mucosa barrier plays a key role in AP's process. Therefore, it is clinically important to study the relationship between the injury of intestinal mucosa barrier and AP. In addition, many factors such as microcirculation disturbance, ischemic reperfusion injury, excessive release of inflammatory mediators and apoptosis may also play important roles in the damage of intestinal mucosa barrier. In this review, we summarize studies on mechanisms of AP.
Zhang
Xi-ping
XP
Department of General Surgery, Hangzhou First People's Hospital, Hangzhou, China. zxp99688@vip.163.com
Zhang
Jie
J
Song
Qiao-ling
QL
Chen
Han-qin
HQ
D000208:Acute Disease; D000818:Animals; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply / Q000293:injuries* / Q000378:metabolism; D044342:Malnutrition / Q000473:pathology; D008833:Microcirculation / Q000378:metabolism; D010195:Pancreatitis / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D015427:Reperfusion Injury / Q000473:pathology