[Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis].
The nasal epithelium is considered to play an active role in the allergic inflammation through its capacity to synthesize and release a wide range of cytokines and mediators. Few studies have investigated the involvement of endothelin-1 in the pathogenesis of inflammatory diseases of the upper airways. To examine the release of endothelin-1 from nasal mucosa after allergen challenge we investigated 24 patients. 15 subjects (7 male, 8 female) allergic to birch pollen aged 37.1 +/- 4.9 years participated in the study. Nasal birch allergen provocation with following lavage was performed in all subjects. Endothelin-1 in the nasal secretion were assayed before and after challenge. Increase in concentration of endothelin-1 in nasal lavage fluid from allergic patients were significantly higher than in control group respectively from 18.33 +/- 5.47 fmol/ml to 26.41 +/- 6.92 fmol/ml versus 18.8 +/- 3.99 to 19.80 +/- 4.18 fmol/ml (p < 0.05) in controls. We conclude that endothelin-1 could be involved in the pathogenesis of seasonal allergic rhinitis.
Gawlik
Radosław
R
Katedra i Klinika Chorób Wewnetrznych, Alergologii i Immunologii Klinicznej Slaskiego Uniwersytetu Medycznego w Katowicach.
Jawor
Barbara
B
D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D009297:Nasal Mucosa / Q000378:metabolism*; D009299:Nasal Provocation Tests; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*
D015415:Biomarkers; D019332:Endothelin-1