Effects of therapeutic doses of lactulose vs. polyethylene glycol on isotopic colonic transit.
BACKGROUND
Lactulose and polyethylene glycol are osmotic agents used to treat idiopathic chronic constipation.


OBJECTIVE
To compare the effects of low doses of lactulose and PEG 4000 on transit time measured by scintigraphy in normal subjects.


METHODS
For 5 days, 10 healthy subjects received either 10 g b.d. of lactulose or PEG 4000 in a randomized, double-blind, crossover study. On the evening of day 4, they took a capsule containing Amberlite resin pellets labelled with (111)In. On day 5, after a 1000 kcal test meal labelled with 99 Tcm, gastric, small bowel and colonic transits were measured.


RESULTS
Gastric emptying and small bowel transit time were not different. Ascending colon emptying curve was significantly accelerated with lactulose in comparison with polyethylene glycol (P = 0.001) and, respectively, 50 +/- 18% vs. 35 +/- 18% of the radioactivity had left the ascending colon at the end of the study (P < 0.05). The descending colon filling curves, variations in the geometric centre and numbers of scintigraphic movements were not different.


CONCLUSIONS
In healthy subjects, in comparison to PEG 4000, usual therapeutic doses of lactulose significantly accelerate ascending colon emptying. This result supports a stimulating motor effect of colonic fermentation of lactulose.
Jouët
P
P
AP-HP, Hôpital Louis Mourier, Department of Hepato-Gastroenterology, Colombes CEDEX, France. pauline.jouet@lmr.aphp.fr
Sabate
J-M
JM
Flourie
B
B
Cuillerier
E
E
Gambini
D
D
Lemann
M
M
Jian
R
R
Coffin
B
B
D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000378:metabolism; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D007792:Lactulose / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D013501:Surface-Active Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D007792:Lactulose