PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma.
PB183, a non-selective sigma receptor ligand displaying high sigma-1 and sigma-2 receptor affinity, was evaluated in prostate tumour cell lines for its suitability as PET radiotracer. The pharmacodynamic and pharmacokinetic properties suggested PB183 as a potential PET radiotracer to visualize prostate adenocarcinoma.
Colabufo
Nicola Antonio
NA
Dipartimento Farmacochimico, Università degli Studi di Bari, via Orabona 4, 70125 Bari, Italy. colabufo@farmchim.uniba.it
Abate
Carmen
C
Contino
Marialessandra
M
Inglese
Carmela
C
Niso
Mauro
M
Berardi
Francesco
F
Perrone
Roberto
R
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000818:Animals; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D005434:Flow Cytometry; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000493:pharmacokinetics; D010879:Piperazines / Q000737:chemistry / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D017480:Receptors, sigma / Q000378:metabolism*; D000097605:Sigma-1 Receptor
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D009281:Naphthalenes; D010879:Piperazines; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor; C529332:PB183 compound; C106107:sigma-2 receptor