[Human HSF1 mutants and their applications].
Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional activity, which dominant-negative HSF1 does not acquire. In this paper, the progress of using these HSF1 mutants in the research of cancer, neurodegenerative disorders and cardiovascular diseases will be discussed.
Huang
Yun-Hong
YH
Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China.
Gong
Shou-Fang
SF
Zou
Jiang-Ying
JY
D015316:Genetic Therapy; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000627:therapeutic use; D006801:Humans; D050505:Mutant Proteins / Q000235:genetics*; D009369:Neoplasms / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000628:therapy*
D006360:Heat-Shock Proteins; D050505:Mutant Proteins