title: Changes in obesity status and lung function decline in a general population sample.
abstract: Aim of this paper was to evaluate the effects of changes in obesity status on lung function decline over an 8-year follow-up. Adults over 24 years (n=1212) from the general population, who participated in both Po River Delta first (PD1, 1980-1982) and second (PD2, 1988-1991) epidemiological surveys, were stratified as "never obese" (BMI < 30 Kg/m(2) at both PD1 and PD2), "becoming obese" (BMI < 30 Kg/m(2) at PD1 and > or = 30 Kg/m(2) at PD2), "always obese" (BMI > or = 30 Kg/m(2) at both PD1 and PD2), and "becoming non-obese" (BMI > or = 30 Kg/m(2) at PD1 and < 30Kg/m(2) at PD2). Linear regression models for changes in FEV(1), FVC, and VC (computed as absolute differences between the values at PD2 and those at PD1) with longitudinal categories of obesity, gender, age, and baseline smoking habits as covariates were applied. The "becoming obese" and "always obese" categories had a significantly greater decline of lung function than "never obese" group; in the "always obese" group, this was true for vital capacities but not FEV(1). Conversely, in the "becoming non-obese" group lung function was at PD2 improved with respect to PD1. Compared with "Never obese" the mean increase in lung function was of 93, 180, and 48 mL for FEV(1), FVC, and VC, respectively. In this general population sample, remaining or becoming obese increases the decline in lung function over 8 years, while becoming non-obese decreases it.
authors.affiliation: Cardio-Thoracic Department, University Hospital of Pisa, Pisa, Italy. francesco.pistelli@ifc.cnr.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Pistelli
authors.forename: Matteo
authors.initials: M
authors.lastname: Bottai
authors.forename: Laura
authors.initials: L
authors.lastname: Carrozzi
authors.forename: Francesco Di
authors.initials: FD
authors.lastname: Pede
authors.forename: Sandra
authors.initials: S
authors.lastname: Baldacci
authors.forename: Sara
authors.initials: S
authors.lastname: Maio
authors.forename: Vito
authors.initials: V
authors.lastname: Brusasco
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pellegrino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Viegi
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D012129:Respiratory Function Tests; D013995:Time; D015430:Weight Gain; D015431:Weight Loss