[The role of brain natriuretic peptide in diagnosis of diastolic myocardial dysfunction in patients with predialysis chronic kidney disease].
Aim of the study was to elucidate possibility of the use of brain and atrial natriuretic peptide (BNP) as a diagnostic marker of diastolic dysfunction (DD) of the left ventricular myocardium in 37 patients with predialysis chronic kidney disease (CKD). We used data of echocardiography and Doppler echocardiography for detection of functional signs of DD and correlated with BNP levels. Patients with signs of DD (81.1%) had significantly higher BNP level than patients without these signs (214.3 +/- 12.3 and 60.6 +/- 17.7 pg/ml, respectively, p < 0.0001). Main parameters of DD correlated significantly with BNP level (r=0.51, p < 0.005) and were independently related to the level of the hormone according the data of multifactorial regression analysis (R2=0.76, p < 0.001). BNP concentration 100 pg/ml in predialysis patients with CKD appears to be not only diagnostic for DD, but also differential index of pseudonormal type of DD.
Belov
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Il'icheva
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D000328:Adult; D005260:Female; D006333:Heart Failure / Q000453:epidemiology / Q000503:physiopathology*; D054144:Heart Failure, Diastolic / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000502:physiology*; D006435:Renal Dialysis
D020097:Natriuretic Peptide, Brain