title: Modulation of signaling pathways by RNA virus capsid proteins.
abstract: Capsid proteins are structural components of virus particles. They are nucleic acid-binding proteins whose main recognized function is to package viral genomes into protective structures called nucleocapsids. Research over the last 10 years indicates that in addition to their role as genome guardians, viral capsid proteins modulate host cell signaling networks. Disruption or alteration of intracellular signaling pathways by viral capsids may benefit replication of the virus by affecting innate immunity and in some cases, may underlie disease progression. In this review, we describe how the capsid proteins from medically relevant RNA viruses interact with host cell signaling pathways.
authors.affiliation: Department of Cell Biology, University of Alberta, Edmonton, Canada.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Urbanowski
authors.forename: Carolina S
authors.initials: CS
authors.lastname: Ilkow
authors.forename: Tom C
authors.initials: TC
authors.lastname: Hobman
mesh_terms: D036022:Capsid Proteins / Q000378:metabolism*; D017934:Coronavirus / Q000378:metabolism; D005416:Flavivirus / Q000378:metabolism; D012328:RNA Viruses / Q000378:metabolism*; D015398:Signal Transduction; D014035:Togaviridae / Q000378:metabolism
chemical_list: D036022:Capsid Proteins