Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism.
Foxp3(+)CD4(+) T cells represent a population of naturally arising suppressor T cells that are crucial for the control of autoimmune responses. The suppressive activity of this T cell subset relies on multiple mechanisms that include secretion of anti-inflammatory factors such as TGF-beta or IL-10. Novel studies now establish that, through the generation of the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to the regulatory activity of Foxp3(+)CD4(+) T cells.
Bynoe
Margaret S
MS
College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA. msb76@cornell.edu
Viret
Christophe
C
D000818:Animals; D005110:Extracellular Space / Q000276:immunology / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000096:biosynthesis*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice; D009711:Nucleotides / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D009711:Nucleotides