title: Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement.
abstract: A sample labeled to be a natural herbal supplement for the enhancement of sexual function, was sent to Health Sciences Authority (HSA) of Singapore for testing. An unknown compound was detected and isolated from the product. The structure of the unknown compound was identified using LC-UV, high-resolution MS, ESI-MS/MS, IR, and NMR. The compound was characterized as a phosphodiesterase-5 (PDE-5) inhibitor, benzamidenafil. This is the first report of benzamidenafil, representing a new class of PDE-5 inhibitors, as an adulterant of a dietary supplement.
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
authors.forename: Peng
authors.initials: P
authors.lastname: Zou
authors.forename: Peiling
authors.initials: P
authors.lastname: Hou
authors.forename: Sharon Sze-Yin
authors.initials: SS
authors.lastname: Oh
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ge
authors.forename: Bosco Chen
authors.initials: BC
authors.lastname: Bloodworth
authors.forename: Min-Yong
authors.initials: MY
authors.lastname: Low
authors.forename: Hwee-Ling
authors.initials: HL
authors.lastname: Koh
mesh_terms: D001549:Benzamides / Q000032:analysis / Q000737:chemistry*; D002853:Chromatography, Liquid; D019587:Dietary Supplements / Q000032:analysis*; D007172:Erectile Dysfunction / Q000178:diet therapy; D005506:Food Contamination; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000032:analysis* / Q000737:chemistry / Q000145:classification*; D012846:Singapore
chemical_list: D001549:Benzamides; D010726:Phosphodiesterase Inhibitors; C530319:benzamidenafil