title: Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
abstract: We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
authors.affiliation: deCODE genetics, 101 Reykjavik, Iceland. julius@decode.is
authors.forename: Julius
authors.initials: J
authors.lastname: Gudmundsson
authors.forename: Patrick
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authors.lastname: Sulem
authors.forename: Thorunn
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authors.lastname: Rafnar
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authors.lastname: Bergthorsson
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authors.lastname: Manolescu
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authors.lastname: Gudbjartsson
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authors.lastname: Sigurdsson
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authors.lastname: Benediktsdottir
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authors.lastname: Blondal
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authors.lastname: Jakobsdottir
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authors.lastname: Kostic
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authors.lastname: Kristinsson
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authors.lastname: Birgisdottir
authors.forename: Shyamali
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authors.lastname: Ghosh
authors.forename: Droplaug N
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authors.lastname: Magnusdottir
authors.forename: Steinunn
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authors.lastname: Thorlacius
authors.forename: Gudmar
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authors.lastname: Thorleifsson
authors.forename: S Lilly
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authors.lastname: Zheng
authors.forename: Jielin
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authors.lastname: Sun
authors.forename: Bao-Li
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authors.lastname: Chang
authors.forename: J Bradford
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authors.lastname: Elmore
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authors.lastname: Breyer
authors.forename: Kate M
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authors.lastname: McReynolds
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authors.lastname: Bradley
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authors.lastname: Wiklund
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authors.lastname: Stattin
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authors.lastname: Lindström
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authors.lastname: Adami
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authors.lastname: McDonnell
authors.forename: Daniel J
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authors.lastname: Schaid
authors.forename: Julie M
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authors.lastname: Cunningham
authors.forename: Liang
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authors.lastname: Wang
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authors.lastname: Cerhan
authors.forename: Jennifer L
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authors.lastname: St Sauver
authors.forename: Sara D
authors.initials: SD
authors.lastname: Isaacs
authors.forename: Kathleen E
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authors.lastname: Wiley
authors.forename: Alan W
authors.initials: AW
authors.lastname: Partin
authors.forename: Patrick C
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authors.lastname: Walsh
authors.forename: Sonia
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authors.lastname: Polo
authors.forename: Manuel
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authors.lastname: Ruiz-Echarri
authors.forename: Sebastian
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authors.lastname: Navarrete
authors.forename: Fernando
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authors.lastname: Fuertes
authors.forename: Berta
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authors.lastname: Saez
authors.forename: Javier
authors.initials: J
authors.lastname: Godino
authors.forename: Philip C
authors.initials: PC
authors.lastname: Weijerman
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: Katja K
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authors.lastname: Aben
authors.forename: J Alfred
authors.initials: JA
authors.lastname: Witjes
authors.forename: Brian K
authors.initials: BK
authors.lastname: Suarez
authors.forename: Brian T
authors.initials: BT
authors.lastname: Helfand
authors.forename: Michael L
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authors.lastname: Frigge
authors.forename: Kristleifur
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authors.lastname: Kristjansson
authors.forename: Carole
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authors.lastname: Ober
authors.forename: Eirikur
authors.initials: E
authors.lastname: Jonsson
authors.forename: Gudmundur V
authors.initials: GV
authors.lastname: Einarsson
authors.forename: Jianfeng
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authors.lastname: Xu
authors.forename: Henrik
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authors.lastname: Gronberg
authors.forename: Jeffrey R
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authors.lastname: Smith
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
authors.forename: William J
authors.initials: WJ
authors.lastname: Catalona
authors.forename: Jose I
authors.initials: JI
authors.lastname: Mayordomo
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Rosa B
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authors.lastname: Barkardottir
authors.forename: Jeffrey R
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authors.lastname: Gulcher
authors.forename: Unnur
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authors.lastname: Thorsteinsdottir
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D016022:Case-Control Studies; D002889:Chromosomes, Human, Pair 2; D041321:Chromosomes, Human, X; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007055:Iceland; D015810:Linkage Disequilibrium; D008297:Male; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D013030:Spain; D013548:Sweden; D014481:United States