Role of coagulation and fibrinolysis in lung and renal fibrosis.
Elevated procoagulant and suppressed fibrinolytic activities are regularly encountered in different forms of clinical and experimental fibrosis of the lungs and the kidneys. Although primarily serving to provide a provisional matrix of repair largely consisting of fibrin and fibronectin, the involved procoagulant serine proteases and protease inhibitors may also exert distinct cellular downstream signaling events modifying the fibrotic response. In this review, evidence for an impaired regulation of coagulation and fibrinolysis factors in clinical and experimental lung and renal fibrosis is provided and the role of PAR (protease activated receptor) induced profibrotic and HGF (hepatocyte growth factor) elicited antifibrotic cellular events is worked out. In view of experiments obtained in animal models of lung and renal fibrosis, the potential therapeutic usefulness of anticoagulant or profibrinolytic strategies is discussed.
Ruppert
C
C
University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany.
Markart
P
P
Wygrecka
M
M
Preissner
K T
KT
Günther
A
A
D000818:Animals; D001777:Blood Coagulation; D004195:Disease Models, Animal; D005342:Fibrinolysis; D005355:Fibrosis; D006487:Hemostasis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000097:blood / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D011658:Pulmonary Fibrosis / Q000097:blood / Q000503:physiopathology*