Variation of a newcastle disease virus hemagglutinin-neuraminidase linear epitope.
Fifty-six Newcastle disease virus strains collected from 2000 to 2006 could be grouped into subgenotype VIId. However, they displayed cumulative mutations in and around the linear epitope of hemagglutinin-neuraminidase (residues 345 to 353) with time. The antigenicities of the variants that became predominant in Korea differ from each other and from the wild type.
Cho
Sun-Hee
SH
Zoonotic Disease Institute, Seoul National University, San 56-1, Shillim-Dong, Gwanak-Gu, Seoul 151-742, South Korea. kwonhj01@snu.ac.kr.
Kwon
Hyuk-Joon
HJ
Kim
Tae-Eun
TE
Kim
Jae-Hong
JH
Yoo
Han-Sang
HS
Kim
Sun-Joong
SJ
D000595:Amino Acid Sequence; D000818:Animals; D000940:Antigenic Variation; D002645:Chickens / Q000821:virology; D000939:Epitopes / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D014644:Genetic Variation; D015707:HN Protein / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D009521:Newcastle Disease / Q000821:virology; D009522:Newcastle disease virus / Q000235:genetics / Q000276:immunology*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D011201:Poultry Diseases / Q000821:virology; D017422:Sequence Analysis, DNA; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000235:genetics
D000939:Epitopes; D015707:HN Protein; D010455:Peptides; D014760:Viral Fusion Proteins