title: Seroprevalence of Chikungunya virus (CHIKV) infection on Lamu Island, Kenya, October 2004.
abstract: An outbreak of Chikungunya virus (CHIKV) disease associated with high fever and severe protracted arthralgias was detected in Lamu, Kenya, peaking in July 2004. At least 1,300 cases were documented. We conducted a seroprevalence study to define the magnitude of transmission on Lamu Island. We conducted a systematic cross-sectional survey. We administered questionnaires and tested 288 sera from Lamu residents for IgM and IgG antibodies to CHIKV. Chikungunya virus infection (seropositivity) was defined as a person with IgG and/or IgM antibodies to CHIKV. IgM antibodies to CHIKV were detected in 18% (53/288) and IgG antibodies in 72% (206/288); IgM and/or IgG antibodies were present in 75% (215/288). The seroprevalence findings suggested that the outbreak was widespread, affecting 75% of the Lamu population; extrapolating the findings to the entire population, 13,500 (95% CI, 12,458-14328) were affected. Vector control strategies are needed to control the spread of this mosquito-borne infection.
authors.affiliation: Field Epidemiology and Laboratory Training Program, Nairobi, Kenya.
authors.forename: Kibet
authors.initials: K
authors.lastname: Sergon
authors.forename: Charles
authors.initials: C
authors.lastname: Njuguna
authors.forename: Rosalia
authors.initials: R
authors.lastname: Kalani
authors.forename: Victor
authors.initials: V
authors.lastname: Ofula
authors.forename: Clayton
authors.initials: C
authors.lastname: Onyango
authors.forename: Limbaso S
authors.initials: LS
authors.lastname: Konongoi
authors.forename: Sheryl
authors.initials: S
authors.lastname: Bedno
authors.forename: Heather
authors.initials: H
authors.lastname: Burke
authors.forename: Athman M
authors.initials: AM
authors.lastname: Dumilla
authors.forename: Joseph
authors.initials: J
authors.lastname: Konde
authors.forename: M Kariuki
authors.initials: MK
authors.lastname: Njenga
authors.forename: Rosemary
authors.initials: R
authors.lastname: Sang
authors.forename: Robert F
authors.initials: RF
authors.lastname: Breiman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018354:Alphavirus Infections / Q000097:blood / Q000453:epidemiology*; D000914:Antibodies, Viral / Q000097:blood*; D002646:Chikungunya virus / Q000276:immunology* / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M