title: HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.
abstract: We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.
authors.affiliation: Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain.
authors.forename: Najat
authors.initials: N
authors.lastname: Mahdi
authors.forename: Khadija
authors.initials: K
authors.lastname: Al-Ola
authors.forename: Abeer M
authors.initials: AM
authors.lastname: Al-Subaie
authors.forename: Muhallab E
authors.initials: ME
authors.lastname: Ali
authors.forename: Zaid
authors.initials: Z
authors.lastname: Al-Irhayim
authors.forename: A Qader
authors.initials: AQ
authors.lastname: Al-Irhayim
authors.forename: Wassim Y
authors.initials: WY
authors.lastname: Almawi
mesh_terms: D000293:Adolescent; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000097:blood / Q000235:genetics* / Q000276:immunology; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000235:genetics* / Q000276:immunology; D002648:Child; D003251:Constriction, Pathologic / Q000097:blood*; D004730:Endothelium, Vascular / Q000473:pathology; D004913:Erythrocytes, Abnormal / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D007511:Ischemia / Q000097:blood*; D008297:Male
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen