Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies.
OBJECTIVE
To identify if a common set of cytokines is elevated in both ovarian cancer and acute coronary syndrome (ACS).


METHODS
A cytokine array (Randox Ltd) was measured in healthy women (n=33), women with ACS (n=21) and ovarian cancer (n=45).


RESULTS
Women with ACS or ovarian cancer had higher concentrations of IL-6, IL-8, VEGF, MCP-1, and EGF as compared to healthy volunteers.


CONCLUSIONS
Common cytokine elevations are present in both ACS and ovarian cancer.
Kavsak
Peter A
PA
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. kavsakp@mcmaster.ca
Lee
Agnes
A
Hirte
Hal
H
Young
Ed
E
Gauldie
Jack
J
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000209:etiology; D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000328:Adult; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000209:etiology; D015854:Up-Regulation / Q000502:physiology*
D000209:Acute-Phase Proteins; D016207:Cytokines