Synthesis and bioevaluation of 22-hydroxyacuminatine analogs.
A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.
Grillet
François
F
Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France.
Baumlová
Barbora
B
Prévost
Grégoire
G
Constant
Jean-François
JF
Chaumeron
Sophie
S
Bigg
Dennis C H
DC
Greene
Andrew E
AE
Kanazawa
Alice
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004264:DNA Topoisomerases, Type I / Q000235:genetics; D006801:Humans; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured
C508964:22-hydroxyacuminatine; D000970:Antineoplastic Agents; D007212:Indolizines; D011804:Quinolines; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I