title: Brazil nuts: an effective way to improve selenium status.
abstract: BACKGROUND
  Brazil nuts provide a rich natural source of selenium, yet no studies have investigated the bioavailability of selenium in humans.
  
  
  OBJECTIVE
  We investigated the efficacy of Brazil nuts in increasing selenium status in comparison with selenomethionine.
  
  
  METHODS
  A randomized controlled trial was conducted with 59 New Zealand adults. Participants consumed 2 Brazil nuts thought to provide approximately 100 mug Se, 100 mug Se as selenomethionine, or placebo daily for 12 wk. Actual intake from nuts averaged 53 mug Se/d (possible range: 20-84 mug Se). Plasma selenium and plasma and whole blood glutathione peroxidase (GPx) activities were measured at baseline and at 2, 4, 8, and 12 wk, and effects of treatments were compared.
  
  
  RESULTS
  Plasma selenium increased by 64.2%, 61.0%, and 7.6%; plasma GPx by 8.3%, 3.4%, and -1.2%; and whole blood GPx by 13.2%, 5.3%, and 1.9% in the Brazil nut, selenomethionine, and placebo groups, respectively. Change over time at 12 wk in plasma selenium (P < 0.0001 for both groups) and plasma GPx activity in the Brazil nut (P < 0.001) and selenomethionine (P = 0.014) groups differed significantly from the placebo group but not from each other. The change in whole blood GPx activity was greater in the Brazil nut group than in the placebo (P = 0.002) and selenomethionine (P = 0.032) groups.
  
  
  CONCLUSIONS
  Consumption of 2 Brazil nuts daily is as effective for increasing selenium status and enhancing GPx activity as 100 mug Se as selenomethionine. Inclusion of this high-selenium food in the diet could avoid the need for fortification or supplements to improve the selenium status of New Zealanders.
authors.affiliation: Department of Human Nutrition, University of Otago, Dunedin, New Zealand. christine.thomson@otago.ac.nz
authors.forename: Christine D
authors.initials: CD
authors.lastname: Thomson
authors.forename: Alexandra
authors.initials: A
authors.lastname: Chisholm
authors.forename: Sarah K
authors.initials: SK
authors.lastname: McLachlan
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Campbell
mesh_terms: D000328:Adult; D031383:Bertholletia; D005247:Feeding Behavior; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D012643:Selenium / Q000097:blood*; D012645:Selenomethionine / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D012645:Selenomethionine; D005979:Glutathione Peroxidase; D012643:Selenium