[Sex influences on opioid pharmacotherapy].
Opioids make up a pharmacological group employed from antiquity for the treatment of various ailments. Nowadays they are far used like palliative of acute or chronic pains of high intensity considering their great analgesic effectiveness. During the last years, many articles have reported sex-related differences in the response of laboratory animals to several opioids. These data is according to the knowledge about sex determining both brain structure and functions. In addition, this sexual dimorphism has been recently reported for women and men treated with opioids. The relevance of this information could give rise to a revision of the dosage traditionally employed by physicians in either sex. The present article covers the main aspects of this subject considering its significance in the pharmacotherapy with opioids.
Díaz
Silvina L
SL
Instituto de Investigaciones Farmacológicas (ININFA, CONICET - UBA). silvinalauradiaz@yahoo.com.ar
D000328:Adult; D004358:Drug Therapy / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000453:epidemiology* / Q000534:rehabilitation*; D017678:Sex Distribution
D012739:Gonadal Steroid Hormones