Mediastinal extravasation of doxorubicin.
A 48-year-old woman with a diagnosis of breast carcinoma was treated with adjuvant chemotherapy through a central venous catheter with subcutaneous reservoir (Port-A-Cath). While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum. The patient recovered without sequelae with conservative therapy. Cytostatic extravasation via central catheter is an uncommon complication in clinical practice. In this paper we present the first doxorubicin extravasation through a central catheter in adults and review the only ten cases found in the literature.
Quintanar Verdúguez
Teresa
T
Servicio de Oncología Médica, Hospital Virgen de la Salud, Toledo, Spain. teresaqv@yahoo.com
Blanco Jarava
Adolfo
A
Martínez-Barbeito
María Blanca
MB
Pangua Méndez
Cristina
C
López Gómez
Luis
L
Andrade Santiago
Jesús
J
Chacón López-Muñiz
Ignacio
I
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008482:Mediastinum / Q000473:pathology*; D008875:Middle Aged; D010996:Pleural Effusion / Q000209:etiology
D000970:Antineoplastic Agents; D004317:Doxorubicin