Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.
A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A).
Hari Babu
T
T
Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
Rama Subba Rao
V
V
Tiwari
Ashok K
AK
Suresh Babu
K
K
Srinivas
P V
PV
Ali
Amtul Z
AZ
Madhusudana Rao
J
J
D000818:Animals; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013329:Structure-Activity Relationship
D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one