Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany.
OBJECTIVE
To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI).


METHODS
Prospective controlled blinded study.


METHODS
Tertiary care center.


METHODS
A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years.


METHODS
Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children.


RESULTS
There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence.


CONCLUSIONS
The ICSI children born at term develop normally, similar to SC children.
Ludwig
Annika
A
Zentrum für Hormon- und Stoffwechselerkrankungen, Reproduktionsmedizin und Gynäkologische Endokrinologie, Endokrinologikum Hamburg, Hamburg, Germany. a.k.ludwig@web.de
Katalinic
Alexander
A
Thyen
Ute
U
Sutcliffe
Alastair G
AG
Diedrich
Klaus
K
Ludwig
Michael
M
D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D004644:Emotions; D005260:Female; D005858:Germany; D006801:Humans; D007360:Intelligence; D008137:Longitudinal Studies; D008297:Male; D008603:Mental Health; D009048:Motor Skills / Q000502:physiology*; D018579:Patient Selection; D011247:Pregnancy; D011446:Prospective Studies; D016037:Single-Blind Method; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000706:statistics & numerical data*