Change in fatty acid composition of serum lipids in obese females after short-term weight-reducing regimen with the addition of n-3 long chain polyunsaturated fatty acids in comparison to controls.
Short-term weight-reducing regimens were shown to influence fatty acid composition of serum lipids unfavorably. Adding long chain n-3 polyunsaturated fatty acids (n-3 LC PUFA) to a low-calorie diet (LCD) could avoid these changes. The aim of this study was to examine the effect of a short-term in-patient weight-reducing regimen including LCD with yogurt enriched by low doses of n-3 PUFA (n-3 LCD). The enriched yogurt contained 790 mg of fish oil, predominantly eicosapentaenoic (20:5n-3; EPA) and docosahexaenoic (22:6n-3; DHA). Forty obese women were randomly assigned to the group consuming LCD and joghurt either with or without n-3 enrichment. Following the 3-week diet in the n-3 LCD group a significantly higher increase in the proportion of n-3 LC PUFA (sum of n-3 FA, EPA and DHA) in serum lipids was confirmed. In phospholipids (PL) a significant difference in the sum of n-6 fatty acids was found, a decrease in the n-3 LCD group and an increase in LCD group. Significantly higher increase in the PL palmitate (16:0) was shown in the LCD group. The results suggest that low doses of n-3 fatty acid enrichment can help to avoid unfavorable changes in fatty acid composition in serum lipids after a short-term weight-reducing regimen.
Hlavatý
P
P
Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic.
Kunešová
M
M
Gojová
M
M
Tvrzická
E
E
Vecka
M
M
Roubal
P
P
Hill
M
M
Hlavatá
K
K
Kalousková
P
P
Hainer
V
V
Žák
A
A
Drbohlav
J
J
D000328:Adult; D000368:Aged; D004038:Diet, Reducing / Q000379:methods*; D002149:Energy Intake / Q000502:physiology; D005227:Fatty Acids / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology; D015014:Yogurt
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils