Acanthosulfate, a sulfated hydroxyhydroquinone sesterterpenoid from the sponge Acanthodendrilla sp.
The marine sponge Acanthodendrilla sp. contains the proteasome inhibitor acanthosulfate ( 4), a disulfated merosesterterpene having a scalarane-type skeleton. The structure of acanthosulfate ( 4), which possesses an unusual configuration, was elucidated by interpretation of spectroscopic data.
West
Lyndon M
LM
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212F, USA. lwest@rx.uga.edu
Faulkner
D John
DJ
D000818:Animals; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D061988:Proteasome Inhibitors; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D006873:Hydroquinones; D061988:Proteasome Inhibitors; D054830:Sesterterpenes; D013463:Sulfuric Acid Esters; C528143:acanthosulfate; C013038:hydroxyhydroquinone