title: Scopolamine for prevention of postoperative nausea in gynecologic laparoscopy, a randomized trial.
abstract: OBJECTIVE
  We sought to estimate effectiveness of transdermal scopolamine to prevent postoperative nausea and vomiting after gynecologic laparoscopy.
  
  
  METHODS
  Patients were randomized to receive preoperative transdermal scopolamine or placebo. Main outcome measure was incidence of nausea during the first 24 hours postoperatively. Wilcoxon rank sum, Student t, chi2, and Fischer exact tests were used for data analysis (Canadian Task Force classification IA).
  
  
  METHODS
  Academic teaching hospital.
  
  
  METHODS
  A total of 48 patients undergoing gynecologic laparoscopy were studied.
  
  
  METHODS
  Randomized administration of transdermal Scopolamine or placebo in patients having gynecologic laparoscopic surgery.
  
  
  RESULTS
  Patients in the scopolamine group had significantly less incidence of nausea (20.8% vs 62.5%, p = .003) and vomiting (8.3% vs 37.5%, p = .016) during the first 24 hours after surgery. Number needed to treat was 3 (95% CI 1.5, 6.1) for nausea and 4 (95% CI 1.9, 14.6) for vomiting. Symptoms of visual disturbance and dry mouth were more common in the scopolamine group.
  
  
  CONCLUSIONS
  Scopolamine patch significantly reduces incidence and severity of nausea and vomiting in the first 24 hours after gynecologic laparoscopic surgery.
authors.affiliation: Department of Obstetrics and Gynecology, Landspitali-University Hospital, Reykjavik, Iceland. jeinarsson@partners.org
authors.forename: Jon I
authors.initials: JI
authors.lastname: Einarsson
authors.forename: Bjarki O
authors.initials: BO
authors.lastname: Audbergsson
authors.forename: Adalbjorn
authors.initials: A
authors.lastname: Thorsteinsson
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000758:Anesthesia / Q000009:adverse effects*; D000932:Antiemetics / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D012601:Scopolamine / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000932:Antiemetics; D012601:Scopolamine