Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds.
Stearoyl CoA desaturase (SCD) is the key enzyme involved in the endogenous synthesis of conjugated linoleic acid (CLA) in ruminants. Changes in the enzymatic activity as a result of SCD gene polymorphism and regulation have been hypothesized to cause diet-independent variations of CLA content in milk. Evidences for the direct influence of SCD polymorphism on fatty acid composition of milk and beef have also been reported. To evaluate genetic differences because of breed and/or selection goal, we investigated the polymorphism of three previously reported single nucleotide polymorphisms located in exon 5 of the SCD gene in 11 cattle breeds raised in Italy and selected for different production goals. Results obtained: (i) evidenced a high variability in the allele frequencies across breeds; (ii) detected three novel haplotypes, one of which is private to indigenous beef breeds, and (iii) showed a significant association between haplotypes and selective goal.
Milanesi
E
E
Sezione di Zootecnica Agraria, Dipartimento di Scienze Animali, Università degli Studi di Milano, Milano, Italy.
Nicoloso
L
L
Crepaldi
P
P
D000818:Animals; D001947:Breeding; D002417:Cattle; D005091:Exons; D005260:Female; D006239:Haplotypes; D007558:Italy; D044243:Linoleic Acids, Conjugated / Q000378:metabolism; D008297:Male; D008460:Meat / Q000032:analysis; D008892:Milk / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D013230:Stearoyl-CoA Desaturase / Q000235:genetics*
D044243:Linoleic Acids, Conjugated; D013230:Stearoyl-CoA Desaturase