Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima.
Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new lignans, acutissimalignans A ( 6) and B ( 7), along with two known lignans and three known ellagic acid derivatives. The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities.
Tuchinda
Patoomratana
P
Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scptc@mahidol.ac.th
Kornsakulkarn
Jittra
J
Pohmakotr
Manat
M
Kongsaeree
Palangpon
P
Prabpai
Samran
S
Yoosook
Chalobon
C
Kasisit
Jitra
J
Napaswad
Chanita
C
Sophasan
Samaisukh
S
Reutrakul
Vichai
V
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D015497:HIV-1 / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D014315:Triterpenes; C529472:acutissimalignan A; C529473:acutissimalignan B