title: Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues.
abstract: A series of constrained pentapeptide analogues of the fragment Abeta(31-35) has been prepared using solid phase synthesis protocols. The results of conformational studies and surface plasmon resonance (SPR) experiments seem to indicate that the affinity of these constrained analogues for immobilized Abeta(25-35) peptide could be related to their ability to adopt a Leu34N-Ile31O beta-turn-like folded conformation.
authors.affiliation: Instituto de Química Médica (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain. pdevega@iqm.csic.es
authors.forename: M Jesús
authors.initials: MJ
authors.lastname: Pérez de Vega
authors.forename: José Luis
authors.initials: JL
authors.lastname: Baeza
authors.forename: M Teresa
authors.initials: MT
authors.lastname: García-López
authors.forename: Miquel
authors.initials: M
authors.lastname: Vila-Perelló
authors.forename: Carmen
authors.initials: C
authors.lastname: Jiménez-Castells
authors.forename: Ana María
authors.initials: AM
authors.lastname: Simón
authors.forename: Diana
authors.initials: D
authors.lastname: Frechilla
authors.forename: Joaquin
authors.initials: J
authors.lastname: del Río
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gutiérrez-Gallego
authors.forename: David
authors.initials: D
authors.lastname: Andreu
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
mesh_terms: D016229:Amyloid beta-Peptides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D015153:Blotting, Western; D002470:Cell Survival; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D007103:Immobilization; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D017433:Protein Structure, Secondary; D051381:Rats; D017208:Rats, Wistar; D020349:Surface Plasmon Resonance
chemical_list: D016229:Amyloid beta-Peptides