Synthesis and structural analysis of polyester prodrugs of norfloxacin.
Two-, three- and four-arm, star-shaped poly(epsilon-caprolactone) and poly(D,L-lactide) homopolymers, and copolymers of epsilon-caprolactone with D,L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel macromolecular prodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated by means of MALDI-TOF MS, NMR and IR studies.
Sobczak
Marcin
M
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wp.pl
Witkowska
Ewa
E
Oledzka
Ewa
E
Kolodziejski
Waclaw
W
D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy; D009643:Norfloxacin / Q000138:chemical synthesis* / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry*; D011522:Protons; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D002247:Carbon Isotopes; D011091:Polyesters; D011355:Prodrugs; D011522:Protons; C033616:poly(lactide); D009643:Norfloxacin