title: The thuggacins, novel antibacterial macrolides from Sorangium cellulosum acting against selected Gram-positive bacteria.
abstract: In our screening program we found an activity against some Gram-positive bacteria, including mycobacteria in the culture supernatant of Sorangium cellulosum strain So ce895. The antibiotic responsible for this activity was isolated and named thuggacin. Initial studies towards the mechanism of action showed that thuggacin A inhibits a late step of the respiratory chain of some bacteria.
authors.affiliation: Research Group Microbial Drugs, Germany. herbert.irschik@helmholtz-hzi.de
authors.forename: Herbert
authors.initials: H
authors.lastname: Irschik
authors.forename: Hans
authors.initials: H
authors.lastname: Reichenbach
authors.forename: Gerhard
authors.initials: G
authors.lastname: Höfle
authors.forename: Rolf
authors.initials: R
authors.lastname: Jansen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D003580:Cytochromes / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D009231:Myxococcales / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D013941:Thymine / Q000096:biosynthesis; D014498:Uracil / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D001426:Bacterial Proteins; D003580:Cytochromes; D018942:Macrolides; C523035:thuggacin A; C523034:thuggacin B; C523033:thuggacin C; D009243:NAD; D014498:Uracil; D013941:Thymine; D010100:Oxygen