title: Renal cell carcinomas arising from the allograft and bilateral native kidneys.
abstract: We present the case of a young lady who developed renal cell carcinomas (RCC) in the allograft and bilateral native kidneys metachronously within one year. She received a living donor kidney transplantation from her father. A solid tumor of 4 cm in diameter was uncovered first in the allograft kidney 103 months after transplantation, and was treated with graftectomy. Six months after graftectomy, a right renal tumor measuring 3.5 cm and left renal tumors emerged in the native kidneys. She underwent laparoscopic right and left radical nephrectomy in separate sessions. The pathological diagnosis in the allograft and right renal tumors was clear cell RCC with eosinophilic cytoplasm and that in the left kidney was clear cell carcinoma. Fluorescence in situ hybridization and human leukocyte antigen typing showed that each tumor was most probably primary disease. She was free of disease 18 months postoperatively. This is the first report on RCC arising both in the allograft and bilateral native kidneys.
authors.affiliation: Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nobushita
authors.forename: Noboru
authors.initials: N
authors.lastname: Hara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Saito
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Kota
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000601:surgery; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D016030:Kidney Transplantation; D019737:Transplants