Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during progression.
A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy showed duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.
Hara
Takeshi
T
The First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Tsurumi
Hisashi
H
Kato
Tomohiro
T
Imao
Yasuyuki
Y
Kojima
Yasushi
Y
Kojima
Keishi
K
Kitagawa
Jun-ichi
J
Katsumura
Naoki
N
Araki
Hiroshi
H
Takami
Tsuyoshi
T
Moriwaki
Hisataka
H
D018450:Disease Progression; D004379:Duodenal Neoplasms / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D007161:Immunoproliferative Small Intestinal Disease / Q000150:complications* / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism
D011506:Proteins