Total synthesis of +-superstolide A.
A convergent and highly stereocontrolled synthesis of +-superstolide A (1) has been accomplished. Key steps of this synthesis include the intramolecular Suzuki reaction of 26 and the highly diastereoselective transannular Diels-Alder cyclization of macrocyclic octaene 3.
Tortosa
Mariola
M
Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA.
Yakelis
Neal A
NA
Roush
William R
WR
D003500:Cyclization; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
D003603:Cytotoxins; D018942:Macrolides; D013764:Tetrahydronaphthalenes; C091984:superstolide A