title: Glutamate/aspartate supplementation during cardiopulmonary bypass: effect on postoperative neurocognitive function.
abstract: In this randomized trial, we investigated the effect of glutamate/aspartate-containing cardioplegia on neurocognitive function in 70 patients undergoing first-time elective coronary artery bypass graft surgery. Half of the patients received glutamate/aspartate, and the other 35 patients served as controls and received crystalloid cardioplegia. Neurocognitive function after surgery was assessed with the Mini-Mental State Examination performed before surgery and again on postoperative day 3. Although patients in both groups scored slightly lower postoperatively (17 versus 18 of a total of 30 points), no significant group differences were found. Our results indicate that glutamate/aspartate supplementation had no impact on neurocognitive function after coronary artery bypass graft surgery.
authors.affiliation: Department of Anesthesiology and Reanimation, Kocatepe University School of Medicine, Afyonkarahisar, Turkey. demetdoganerol@mynet.com
authors.forename: Demet Dogan
authors.initials: DD
authors.lastname: Erol
authors.forename: Halil Arif
authors.initials: HA
authors.lastname: Ibis
mesh_terms: D000368:Aged; D001224:Aspartic Acid / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D003071:Cognition; D003072:Cognition Disorders / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D018698:Glutamic Acid / Q000008:administration & dosage*; D006305:Health Status Indicators; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D049590:Postpartum Period; D011581:Psychological Tests; D011594:Psychometrics; D012307:Risk Factors
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid