Pyramidal neurons grow up and change their mind.
The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical pyramidal cell populations. Here, we discuss these new findings in the context of our present understanding of cortical cell specification.
Fishell
Gord
G
New York University School of Medicine, New York, NY 10016, USA. fishell@saturn.med.nyu.edu
Hanashima
Carina
C
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D008322:Mammals; D009434:Neural Pathways / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
D015816:Cell Adhesion Molecules, Neuronal; C486733:Stab2 protein, mouse; D014157:Transcription Factors