Anxiogenic effect of chronic exposure to extremely low frequency magnetic field in adult rats.
Previous study has suggested some relations between extremely low frequency magnetic field (ELF MF) and the emotional state of human beings and animals. The aim of the present study was to investigate whether the anxiety level could be affected by repeated ELF MF exposure of different daily durations. Adult SD rats were submitted to no exposure, MF exposure 1h/day or 4h/day for 25 days. Anxiety-related behaviors were examined in the open field test (OFT), the elevated plus maze (EPM), and light/dark box on the 21th, 23th and 25th exposure day, respectively. Results demonstrated that MF exposure 4h/day increased the anxiety-like behaviors in rats in the open field test and the elevated plus maze test, without altering their locomotor activity, but had no effect in the light/dark box test. Moreover, MF exposure 1h/day had no effect in any test. These findings indicate that chronic ELF MF exposure has anxiogenic effect in rats, which is dependent on the daily exposure duration and it is more sensitive to void space than to strong light.
Liu
Tongtong
T
Department of Occupational and Environmental Health, School of Public Health, Peking University Health Science Center, Beijing 100083, PR China.
Wang
Sheng
S
He
Lihua
L
Ye
Kangping
K
D000818:Animals; D001007:Anxiety / Q000209:etiology / Q000503:physiopathology; D001008:Anxiety Disorders / Q000209:etiology* / Q000503:physiopathology; D001522:Behavior, Animal / Q000502:physiology / Q000528:radiation effects; D001921:Brain / Q000503:physiopathology / Q000528:radiation effects*; D002940:Circadian Rhythm / Q000502:physiology / Q000528:radiation effects; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005106:Exploratory Behavior / Q000502:physiology / Q000528:radiation effects; D008027:Light / Q000009:adverse effects; D008297:Male; D018782:Maze Learning / Q000502:physiology / Q000528:radiation effects; D009043:Motor Activity / Q000502:physiology / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors