Eye movements as a marker for cerebellar damage in paraneoplastic neurological syndromes.
Cerebellar disturbances can induce a variety of motor deficits, ranging from severe ataxia to mild deficits of fine motor control. Although motor disturbances appear as an important clinical feature in many neurological disorders, mild disturbances are often difficult to assess properly. Eye movement recordings using video-oculography in a group of patients with a paraneoplastic neurological disorder revealed subtle saccadic and smooth pursuit deficits when compared to controls. We conclude that an easy quantification of eye movement control may assist in the diagnosis and follow-up of mild motor disturbances in patients with neurological disorders, especially when such signs are not overt during clinical neurological examination.
van Broekhoven
P C A
PC
Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Frens
M A
MA
Sillevis Smitt
P A
PA
van der Geest
J N
JN
D000368:Aged; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology*; D004585:Electrooculography; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis / Q000503:physiopathology*; D013577:Syndrome