title: Chlorine inactivation of highly pathogenic avian influenza virus (H5N1).
abstract: To determine resistance of highly pathogenic avian influenza (H5N1) virus to chlorination, we exposed allantoic fluid containing 2 virus strains to chlorinated buffer at pH 7 and 8, at 5 degrees C. Free chlorine concentrations typically used in drinking water treatment are sufficient to inactivate the virus by >3 orders of magnitude.
authors.affiliation: US Environmental Protection Agency, Cincinnati, Ohio 45268, USA. rice.gene@epa.gov
authors.forename: Eugene W
authors.initials: EW
authors.lastname: Rice
authors.forename: Noreen J
authors.initials: NJ
authors.lastname: Adcock
authors.forename: Mano
authors.initials: M
authors.lastname: Sivaganesan
authors.forename: Justin D
authors.initials: JD
authors.lastname: Brown
authors.forename: David E
authors.initials: DE
authors.lastname: Stallknecht
authors.forename: David E
authors.initials: DE
authors.lastname: Swayne
mesh_terms: D000818:Animals; D002645:Chickens; D002713:Chlorine / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods; D054879:Halogenation; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D005585:Influenza in Birds / Q000517:prevention & control*; D038301:Virus Inactivation / Q000187:drug effects*; D018508:Water Purification / Q000379:methods*
chemical_list: D004202:Disinfectants; D002713:Chlorine