Glycopeptide dendrimers, part III: a review. Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases.
Glycopeptide dendrimers containing different types of tumor associated-carbohydrate antigens (T(N), TF, sialyl-T(N), sialyl-TF, sialyl-Le(x), sialyl-Le(a) etc.) were used in diagnosis and therapy of different sorts of cancer. These dendrimeric structures with incorporated T-cell epitopes and adjuvants can be used as antitumor vaccines. Best results were obtained with multiantigenic vaccines, containing, e.g. five or six different TAAs. The topic of TAAs and their dendrimeric forms at molecular level are reviewed, including structure, syntheses, and biological activities. Use of glycopeptide dendrimers as antiviral vaccines against HIV and influenza is also described. Their syntheses, physico-chemical properties, and biological activities are given with many examples.
Niederhafner
Petr
P
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 6, Czech Republic.
Reinis
Milan
M
Sebestík
Jaroslav
J
Jezek
Jan
J
D016915:AIDS Vaccines / Q000737:chemistry / Q000627:therapeutic use; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry / Q000145:classification; D019496:Cancer Vaccines / Q000737:chemistry / Q000627:therapeutic use; D002240:Carbohydrate Sequence; D050091:Dendrimers / Q000737:chemistry / Q000627:therapeutic use*; D006020:Glycopeptides / Q000737:chemistry / Q000627:therapeutic use*; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007252:Influenza Vaccines / Q000737:chemistry / Q000627:therapeutic use; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000627:therapeutic use; D014765:Viral Vaccines / Q000737:chemistry / Q000627:therapeutic use; D014777:Virus Diseases / Q000175:diagnosis / Q000628:therapy
D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D015295:Antigens, Tumor-Associated, Carbohydrate; D019496:Cancer Vaccines; D050091:Dendrimers; D006020:Glycopeptides; D007252:Influenza Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines