Secreting tumor suppression.
Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment.
Chien
Yuchen
Y
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Lowe
Scott W
SW
D000818:Animals; D017209:Apoptosis; D016922:Cellular Senescence; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism*; D008544:Melanocytes / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D009508:Nevus, Pigmented / Q000378:metabolism; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*
D018969:Insulin-Like Growth Factor Binding Proteins; C102529:insulin-like growth factor binding protein-related protein 1; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf