Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus.
Silymarin (70 mg/kg) and succinic acid (50 mg/kg) reduce blood glucose and cholesterol concentrations, inhibit LPO, and correct oxidative phosphorylation disturbances in liver mitochondria in experimental diabetes mellitus induced by injection of streptozotocin (65 mg/kg) in rats.
Vengerovskii
A I
AI
Department of Pharmacology, Siberian State Medical University, Tomsk. edu@ssmu.ru
Khazanov
V A
VA
Eskina
K A
KA
Vasilyev
K Yu
KY
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000188:drug therapy; D010085:Oxidative Phosphorylation / Q000187:drug effects; D012838:Silymarin / Q000627:therapeutic use*; D019802:Succinic Acid / Q000627:therapeutic use*
D001786:Blood Glucose; D012838:Silymarin; D002784:Cholesterol; D019802:Succinic Acid