[Anti-apoptotic effect of the androgen receptor in human prostate cancer].
Prostate cancer is one of the common cancers in old men. Androgen ablation is a major option for the treatment of the metastatic diseases. However, most of the cancers progress to a more aggressive stage, so-called androgen-independent (or hormone refractory) relapse beyond any cure. The androgen receptor (AR) is an important factor in regulating the differentiation and proliferation of prostate epithelial cells, and also plays a critical role in cellular survival. Studies have demonstrated that aberrant activation of the AR is a major determinant in prostate cancer progression. We have provide a brief summary of AR-mediated cellular survival and an introduction to the advances of RNA interference techniques in silencing AR expression as a novel therapy for prostate cancer.
Shen
Fang-Yun
FY
Department of Urology, Shenzhen Sun Hospital of Dalian Medical University, Shenzhen, Guangdong 518000, China. shenfangyun@hotmail.com
Li
Ben-Yi
BY
D017209:Apoptosis / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D034622:RNA Interference; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology*
D011944:Receptors, Androgen