[Angiotensin II-receptor antagonists compared to other antihypertensives: still insufficient evidence for reducing the risk of cerebrovascular incidents].
--There is growing evidence that angiotensin II-receptor antagonists may have protective effects for preventing cerebrovascular incidents. --It is unlikely that these effects are due only to a decrease in blood pressure. --One hypothesis is that high concentrations ofangiotensin II result in improved cerebral perfusion ofangiotensin type 2-receptor mediated mechanisms such as local vasodilatation and angiogenesis. --Several clinical and preclinical studies support this hypothesis. --The results of these studies are discussed in this overview. There is still insufficient evidence that a protective effect on the brain occurs.
Meerum Terwogt
J M
JM
Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, afd. Medische Oncologische Disciplines, Amsterdam. j.meerum@nki.nl
Koopmans
R P
RP
Roos
Y B W E M
YB
van Montfrans
G A
GA
D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D057912:Angiotensin II Type 2 Receptor Blockers; D000959:Antihypertensive Agents / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000517:prevention & control*
D047228:Angiotensin II Type 1 Receptor Blockers; D057912:Angiotensin II Type 2 Receptor Blockers; D000959:Antihypertensive Agents