title: Poor correlation between coronary artery calcification and obstructive coronary artery disease in an end-stage renal disease patient.
abstract: Vascular calcification is highly prevalent and often severe in patients with chronic kidney disease. Arterial calcification in patients with chronic kidney disease can result from the deposition of mineral along the intimal layer of arteries in conjunction with atheromatous plaques or from calcium deposition in the medial wall of arteries, also known as Monckeberg's sclerosis. Whether coronary artery calcium scores as measured by electron beam computed tomography correlate with occlusive atherosclerotic disease in the dialysis population is uncertain. Here we report a case of an asymptomatic patient with diabetes mellitus and end-stage renal disease undergoing maintenance hemodialysis, who was found to have extremely elevated coronary artery calcium scores on electron beam computed tomography, but varied degrees of atherosclerotic plaque in her coronary arteries on coronary angiography. This suggests that in addition to the calcification anticipated in a remodeled intima, a proportion of the calcification is also likely to be in the arterial media. Thus, this case demonstrates that even an extremely high coronary calcium score may not be a satisfactory surrogate marker for obstructive atherosclerosis in elderly diabetic dialysis patients.
authors.affiliation: Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Torrance, California, U.S.A.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Tong
authors.forename: Rajnish
authors.initials: R
authors.lastname: Mehrotra
authors.forename: David M
authors.initials: DM
authors.lastname: Shavelle
authors.forename: Matthew
authors.initials: M
authors.lastname: Budoff
authors.forename: Sharon
authors.initials: S
authors.lastname: Adler
mesh_terms: D001157:Arterial Occlusive Diseases / Q000453:epidemiology*; D002102:Cadaver; D002114:Calcinosis / Q000453:epidemiology*; D003327:Coronary Disease / Q000453:epidemiology*; D004502:Education, Medical, Continuing; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D019520:Living Donors / Q000706:statistics & numerical data; D015141:Los Angeles; D009398:Nephrology / Q000706:statistics & numerical data; D006435:Renal Dialysis / Q000379:methods*; D012577:Schools, Medical; D014019:Tissue Donors / Q000706:statistics & numerical data