title: Giant mature ovarian cystic teratoma including more than 300 teeth.
abstract: Preoperative diagnosis of malignant tumors arising from mature cystic teratoma (MCT) of the ovary is not easy; malignant tumors are mostly diagnosed only postoperatively. Tumor size, serum tumor markers, and patient age have been proposed as risk factors for malignancy. This article reports a rare case of a giant, benign MCT of the ovary in a young woman (25 years old). It had a very large size (320 x 270 x 185 mm, 10 kg), a great number of teeth (> 300), and preoperative serum level of tumor markers were elevated (CA125, 875 U/mL(-1); CA19-9, 2087 U/mL(-1); CEA, 5.1 ng/mL(-1); AFP, 23.3 ng/mL(-1); SCC, 20.7 ng/mL(-1)). Based on clinical and laboratory data, tumor markers and tumor size when used alone or in combination do not appear to be useful in making a differential diagnosis between MCT and squamous cell carcinoma arising from MCT. However, radiologically detectable, well-differentiated teeth may be indicative of benignity.
authors.affiliation: Inserm, Clermont-Ferrand, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Devoize
authors.forename: Denise
authors.initials: D
authors.lastname: Collangettes
authors.forename: Guillaume
authors.initials: G
authors.lastname: Le Bouëdec
authors.forename: Florence
authors.initials: F
authors.lastname: Mishellany
authors.forename: Thierry
authors.initials: T
authors.lastname: Orliaguet
authors.forename: Radhouane
authors.initials: R
authors.lastname: Dallel
authors.forename: Martine
authors.initials: M
authors.lastname: Baudet-Pommel
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology*; D011237:Predictive Value of Tests; D011506:Proteins / Q000032:analysis; D015843:Serpins / Q000032:analysis; D013724:Teratoma / Q000276:immunology / Q000473:pathology*; D014070:Tooth; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D047908:Intracellular Signaling Peptides and Proteins; C549756:NBR1 protein, human; D011506:Proteins; D015843:Serpins; D000509:alpha-Fetoproteins; C051072:squamous cell carcinoma-related antigen