title: Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin.
abstract: This work reports the cloning and sequence determination of the horse alpha subunit of the integrin CD11c/CD18, a marker of dendritic cells. A cDNA clone of 4582 base pairs was obtained. It encodes a protein segment of 1086 amino acid residues of the extracellular domain with 10 potential sites of glycosylation, a transmembrane domain of 32 residues and a C-terminal cytoplasmic tail of 24 residues. A phylogenetic analysis of this integrin shows close similarity (83%) with that of Canis familiaris.
authors.affiliation: Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca 62210, Mexico.
authors.forename: Gerardo P
authors.initials: GP
authors.lastname: Espino-Solis
authors.forename: Joel
authors.initials: J
authors.lastname: Osuna-Quintero
authors.forename: Lourival D
authors.initials: LD
authors.lastname: Possani
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D039521:CD11c Antigen / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D018821:CD18 Antigens / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D003001:Cloning, Molecular; D006736:Horses / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D039521:CD11c Antigen; D018821:CD18 Antigens