title: Neurodevelopmental outcome of very-low-birth-weight infants with chorioamnionitis.
abstract: BACKGROUND
  Chorioamnionitis (CAM) is one of the main causes of preterm labor and has been associated with an adverse perinatal outcome in preterm infants.
  
  
  OBJECTIVE
  The specific aim of our study was to evaluate whether there is significant difference in the Bayley developmental index scores at 6, 12, 18 and 24 months of corrected age for very-low-birthweight (birth body weight <1500 gm, VLBW) infants with or without placental CAM.
  
  
  METHODS
  Ninety-five cases (54 in CAM and 41 in non-CAM groups) available for the study were all VLBW infants with adequate histologic placental material for analysis. Neonatal characteristics and morbidities were recorded. The infants were followed up prospectively with Bayley Scales of Infant Development in the Neonatal Follow-up Clinic for 2 years.
  
  
  RESULTS
  We found that 56.8% of placentas presented a picture of CAM. In comparison of the neonatal characteristics, VLBW infants with CAM had shorter gestational age (27.9 +/- 2.8 vs. 30.0 +/- 3.7 weeks, p = 0.003), lower Cesarean delivery rate (48.1% vs. 73.2%, p = 0.011), more maternal steroid use (44.4% vs. 12.2%, p = 0.004) and higher incidence of preterm premature rupture of membrane (PPROM, 37.0% vs. 12.2%, p = 0.009). In comparison of neonatal outcomes, the CAM group had higher incidence of bronchopulmonary dysplasia (BPD, 40.7% vs. 19.5%, p = 0.044), more mechanical ventilation (87.0% vs. 27/41, p = 0.023) and intubation (68.5% vs. 46.3%, p = 0.049), and more median days of ventilation (23.1 +/- 29.1 vs. 7.8. +/- 13.7 days, p = 0.001). As for the follow-up, at any test age, either the mean (Mental Development Index (MDI) / (Psychomotor Development Index (PDI) scores of Bayley test or the incidence of score below 85, there was no significant difference in both groups.
  
  
  CONCLUSIONS
  The VLBW infants with histologic chorioamnionitis were not associated with an increased risk of lower MDI or PDI scores at the corrected ages of 6, 12, 18 and 24 months compared with the non-CAM control group.
authors.affiliation: National Yang-Ming University, Shin-Kong Wu Ho-Su Memorial Hospital.
authors.forename: Shu-Chi
authors.initials: SC
authors.lastname: Mu
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Lin
authors.forename: Tseng-Chen
authors.initials: TC
authors.lastname: Sung
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Chen
authors.forename: Yi-Chieh
authors.initials: YC
authors.lastname: Lin
authors.forename: Chin-Cheng
authors.initials: CC
authors.lastname: Lee
authors.forename: Tong-Jong
authors.initials: TJ
authors.lastname: Chen
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Lin
authors.forename: Guey-Mei
authors.initials: GM
authors.lastname: Jow
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000209:etiology; D002657:Child Development; D002821:Chorioamnionitis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D009420:Nervous System / Q000254:growth & development*; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy