title: Plasma kinetics and urine profile of ethyl glucosides after oral administration in the rat.
abstract: In this in vivo study, the time course of plasma concentration and the urinary excretion of ethyl alpha-D-glucoside (alpha-EG) and ethyl beta-D-glucoside (beta-EG) were investigated in rats after a single oral dose of 4 mmol/kg body weight. Maximal plasma concentrations of both alpha-EG and beta-EG (EGs) reached approximately 3 mM at 1 h after oral administration and then decreased rapidly. Approximately 80% of EGs administered were excreted into the urine during the first 6 h. Within 24 h, cumulative urinary alpha-EG and beta-EG excretions were estimated to be 87.2+/-7.9% and 85.4+/-5.0%, respectively. Traces of both EGs were detected in plasma and urine 24 h after oral ingestion. The results of this study indicate that almost all of both EGs was rapidly absorbed into the blood stream and easily excreted into the urine after oral administration, and that a small amount of them remained in the rat body 24 h after administration.
authors.affiliation: Faculty of Applied Biological Sciences, Gifu University, Japan. mishima@u-gifu-ms.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Mishima
authors.forename: Shinpei
authors.initials: S
authors.lastname: Harino
authors.forename: Jun
authors.initials: J
authors.lastname: Sugita
authors.forename: Michio
authors.initials: M
authors.lastname: Nakahara
authors.forename: Tohru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayakawa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004563:Electrochemistry; D005960:Glucosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats
chemical_list: D005960:Glucosides