[Glycated albumin level and its influential factors in type 2 diabetes mellitus].
OBJECTIVE
To provide evidence for assessing glycated albumin (GA) appropriately cliniccally through determining the GA level of type 2 diabetes mellitus (DM) patients and analyzing its influential factors.


METHODS
Continuous glucose monitor system was used to monitor the levels of fasting plasmic glucose (FPG), 2-hour post-prandial plasmic glucose (2hPG), GA, and glycated hemoglobin (HbA1c) in 445 type 2 DM in-patients.


RESULTS
(1) The mean GA value was 24.9% +/- 7.0% and the mean HbA1c was 8.9% +/- 2.2%. (2) GA value was associated with HbA1c (P < 0.001). GA was positively correlated with FPG, 2hPG, and mean blood glucose (MBG) (all P < 0.01). (3) GA value was negatively correlated with BMI (P < 0.01). (4) Multiple stepwise regression analysis showed that HbA1c, BMI, and FPG were the main influential factors of GA.


CONCLUSIONS
(1) GA value has good relationship with HbA1c, a golden standard to reflect the glycemic control in a long period. (2) BMI should be concerned when assessing GA value of DM patients, especially of the obese and thin subjects.
Li
Qing
Q
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People Hospital, Shanghai, China.
Wu
Song-Hua
SH
Pan
Jie-Min
JM
Tang
Jun-Ling
JL
Zhang
Yang
Y
Lu
Hui-Juan
HJ
Bao
Yu-Qian
YQ
Jia
Wei-Ping
WP
Xiang
Kun-San
KS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006031:Glycosylation; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin