Structural insights into DNA lesion bypass.
A number of highly specialized DNA polymerases with the ability to replicate through DNA lesions have been identified. In this issue of Structure, Nair et al. show how one such polymerase, yeast Rev1, accomplishes the DNA lesion bypass task.
Sung
Patrick
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D001120:Arginine / Q000737:chemistry; D020029:Base Pairing; D004247:DNA / Q000096:biosynthesis* / Q000737:chemistry; D004249:DNA Damage; D003845:Deoxycytosine Nucleotides / Q000737:chemistry; D009713:Nucleotidyltransferases / Q000737:chemistry* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000378:metabolism; D000099270:Y-Family DNA Polymerases
D001120:Arginine; D004247:DNA; D003845:Deoxycytosine Nucleotides; D009713:Nucleotidyltransferases; D029701:Saccharomyces cerevisiae Proteins; C024107:2'-deoxycytidine 5'-triphosphate; C100951:REV1 protein, S cerevisiae; D000099270:Y-Family DNA Polymerases