[Effect of Yishen capsule on serum vascular endothelial growth factor and cell immunity in patients with chronic glomerulonephritis].
OBJECTIVE
To explore the effect of Yishen capsule on the serum vascular endothelial growth factor (VEGF), the cell immunity and the theraphic.


METHODS
Serum VEGF and T cell subsets were studied in 30 normal subjects and 83 patients before and after treatment.


RESULTS
Compare with normal subjects, CD3, CD4, CD4/CD8 were decreased, CD8 and serum VEGF were increased obviously (P <0. 05 or P <0. 01). After three months treatment with YiShen capsule, CD4/CD8 was increased, CD8 and serum VEGF were decreased significantly (P <0.05 or P <0.01).


CONCLUSIONS
Yishen capsule can reduce the proteinuria, increase the function of immunity and improve the clinical symptom of patients with chronic glomerulonephritis, achieved the effects of allevating chronic glomerular sclerosis ultimately.
Wu
Xi-li
XL
Department of Integrated Chinese Traditional and Western Medicine, Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China. wuxili1984@163.com
Sun
Wan-sen
WS
Zhang
Wang-gang
WG
Qiao
Cheng-lin
CL
Wang
Zhu
Z
Wang
Juan
J
D000293:Adolescent; D000328:Adult; D017252:CD3 Complex / Q000097:blood; D015704:CD4 Antigens / Q000097:blood; D016516:CD4-CD8 Ratio; D002214:Capsules; D002648:Child; D002908:Chronic Disease; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
D017252:CD3 Complex; D015704:CD4 Antigens; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D042461:Vascular Endothelial Growth Factor A; C525740:yishen