title: Hemocompatibility and antibacterial properties of lanthanum oxide films synthesized by dual plasma deposition.
abstract: Lanthanum oxide (La(2)O(3)) films with good hemocompatibility and antibacterial properties have been fabricated using dual plasma deposition. X-ray photoelectron spectroscopy (XPS) shows that La exists in the +3 oxidation state. The band gap of the materials is determined to be 3.6 eV. Activated partial thromboplastin time (APTT) and blood platelet adhesion tests were used to evaluate the blood compatibility. The bacteria, Staphylococcus aureus, were used in plate counting tests to determine the surface antibacterial properties. The APTT is a little longer than those of blood plasma and stainless steel (SS). Furthermore, the numbers of adhered, aggregated, and morphologically changed platelets are reduced compared with those on low-temperature isotropic carbon and SS. The antibacterial plate-counting test indicates that La(2)O(3) has good antibacterial activity against S. aureus. These unique hemocompatibility and antibacterial properties make La(2)O(3) useful in many biomedical applications.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People's Republic of China.
authors.forename: F J
authors.initials: FJ
authors.lastname: Jing
authors.forename: N
authors.initials: N
authors.lastname: Huang
authors.forename: Y W
authors.initials: YW
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: X B
authors.initials: XB
authors.lastname: Zhao
authors.forename: R K Y
authors.initials: RK
authors.lastname: Fu
authors.forename: J B
authors.initials: JB
authors.lastname: Wang
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Shao
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.forename: Y X
authors.initials: YX
authors.lastname: Leng
authors.forename: X Y
authors.initials: XY
authors.lastname: Liu
authors.forename: P K
authors.initials: PK
authors.lastname: Chu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D007811:Lanthanum / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D010087:Oxides / Q000737:chemistry / Q000494:pharmacology; D010973:Platelet Adhesiveness; D013211:Staphylococcus aureus / Q000187:drug effects*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D010087:Oxides; C103829:lanthanum oxide; D007811:Lanthanum