T-helper 1-related chemokines in the exacerbation of childhood asthma.
BACKGROUND
T-helper (Th) 2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon-inducible protein 10 (IP-10)/CXCL10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. The aim of the present study was to evaluate the role of Th1- and Th2- related chemokines in the pathogenesis of asthma exacerbation.


METHODS
Plasma levels of the Th2-related C-C chemokine I-309 (CCL1), the Th1-related CXC chemokines IP-10, and the monokine induced by interferon-gamma (Mig)/CXCL9 were measured in patients with stable asthma.


RESULTS
These results were compared to the results measured prior to, and after corticosteroid treatment, in patients who experienced asthma exacerbations. A significant increase in the plasma levels of IP-10 and Mig, but not I-309, were found in patients with an acute exacerbation in contrast to patients with stable asthma. Plasma levels of IP-10 and Mig were significantly higher in patients during an acute asthma exacerbation than during a subsequent convalescent period.


CONCLUSIONS
The Th1-related CXC chemokines IP-10 and Mig may be useful inflammatory markers of asthma exacerbation in children.
Lai
Shu-Tse
ST
Department of Pediatrics, Wei Gong Memorial Hospital, Miaoli, Taiwan.
Hung
Chih-Hsing
CH
Hua
Yi-Ming
YM
Hsu
Shih-Hsien
SH
Jong
Yuh-Jyh
YJ
Suen
Jau-Ling
JL
D000293:Adolescent; D001249:Asthma / Q000503:physiopathology*; D054402:Chemokine CCL1 / Q000097:blood*; D054357:Chemokine CXCL10 / Q000097:blood*; D054370:Chemokine CXCL9 / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male
C065971:CCL1 protein, human; D054402:Chemokine CCL1; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9