title: Free circulating mRNA in plasma from breast cancer patients and clinical outcome.
abstract: We studied by real-time PCR cyclin D1 and thymidylate synthase (TS) mRNA in plasma as possible markers of clinical outcome in breast cancer. We observed poor outcome in patients with presence of cyclin D1 mRNA in good-prognosis groups, such as negative vascular invasion. Presence of both markers was associated with non-response to treatment after relapse. In patients treated with tamoxifen, a trend to significant relation between poor outcome and cyclin D1 mRNA was found. Cyclin D1 mRNA in plasma could identify patients with poor overall survival in good-prognosis groups and patients non-responsive to tamoxifen.
authors.affiliation: Department of Medical Oncology, Hospital Universitario Puerta de Hierro, C/ San Martín de Porres, 4, E-28035 Madrid, Spain.
authors.forename: Vanesa
authors.initials: V
authors.lastname: García
authors.forename: José M
authors.initials: JM
authors.lastname: García
authors.forename: Cristina
authors.initials: C
authors.lastname: Peña
authors.forename: Javier
authors.initials: J
authors.lastname: Silva
authors.forename: Gemma
authors.initials: G
authors.lastname: Domínguez
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Lorenzo
authors.forename: Raquel
authors.initials: R
authors.lastname: Diaz
authors.forename: Pablo
authors.initials: P
authors.lastname: Espinosa
authors.forename: Javier García
authors.initials: JG
authors.lastname: de Sola
authors.forename: Blanca
authors.initials: B
authors.lastname: Cantos
authors.forename: Félix
authors.initials: F
authors.lastname: Bonilla
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000401:mortality; D019938:Cyclin D1 / Q000032:analysis* / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D011379:Prognosis; D011446:Prospective Studies; D012333:RNA, Messenger / Q000097:blood*; D016019:Survival Analysis; D013629:Tamoxifen / Q000627:therapeutic use; D013940:Thymidylate Synthase / Q000097:blood / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D012333:RNA, Messenger; D013629:Tamoxifen; D019938:Cyclin D1; D013940:Thymidylate Synthase