title: A locus for autosomal dominant progressive non-syndromic hearing loss, DFNA27, is on chromosome 4q12-13.1.
abstract: We ascertained a large North American family, LMG2, segregating progressive, non-syndromic, sensorineural hearing loss. A genome-wide scan identified significant evidence for linkage (maximum logarithm of the odds (LOD) score = 4.67 at theta = 0 for D4S398) to markers in a 5.7-cM interval on chromosome 4q12-13.1. The DFNA27 interval spans 8.85 Mb and includes at least 61 predicted and 8 known genes. We sequenced eight genes and excluded them as candidates for the DFNA27 gene.
authors.affiliation: National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Peters
authors.forename: R A
authors.initials: RA
authors.lastname: Fridell
authors.forename: E T
authors.initials: ET
authors.lastname: Boger
authors.forename: T B
authors.initials: TB
authors.lastname: San Agustin
authors.forename: A C
authors.initials: AC
authors.lastname: Madeo
authors.forename: A J
authors.initials: AJ
authors.lastname: Griffith
authors.forename: T B
authors.initials: TB
authors.lastname: Friedman
authors.forename: R J
authors.initials: RJ
authors.lastname: Morell
mesh_terms: D000328:Adult; D000368:Aged; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree