title: Partial blood recirculation: a new trial for prolonging filter life during continuous hemodiafiltration.
abstract: Although continuous hemodiafiltration (CHDF) has been widely accepted in the management of complicated acute renal failure, the requirement for prolonged continuous systemic anticoagulation appears to be a major drawback. We herein describe the case of a patient who developed postoperative multiple organ failure and received CHDF therapy with partial blood recirculation (PBR). PBR is a mode of extracorporeal circulation used as an anticoagulation modality. The technique accelerates the blood flow rate with the goal of extending filter life, and it was performed because the filter life had been significantly shortened (10.5 +/- 5.1 h) during the CHDF process in this case. Despite increasing the dose of the anticoagulant, changing the hemofilter and changing the mode from postdilution to predilution, we did not obtain amelioration of filter life. The filter life was significantly improved (41.5 +/- 1.4 h) when we performed PBR. It is difficult to minimize the bleeding risk and maintain filter life during CHDF. Our success in prolonging the filter life during this case therefore suggests that PBR might resolve one of the main problems related to CHDF, although more study is needed to clarify the advantages of this system.
authors.affiliation: Department of Internal Medicine, Saga Medical School, Saga, Japan. ikedayuu@cc.saga-u.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kishi
authors.forename: Chie
authors.initials: C
authors.lastname: Kishi
authors.forename: Motoaki
authors.initials: M
authors.lastname: Miyazono
authors.forename: Yukio
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Mikio
authors.initials: M
authors.lastname: Nakashima
authors.forename: Takanobu
authors.initials: T
authors.lastname: Sakemi
authors.forename: Toru
authors.initials: T
authors.lastname: Sanai
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D001783:Blood Flow Velocity; D004867:Equipment Design; D004868:Equipment Failure; D017583:Hemodiafiltration / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy; D011183:Postoperative Complications / Q000628:therapy
chemical_list: D000925:Anticoagulants