[Expression of HOX C13 in odontogenic tumors].
OBJECTIVE
To study the expression of HOXC13 mRNA in odontogenic tumors.


METHODS
HOXC13 mRNA was detected in 47 cases of ameloblastoma (AB), 3 cases of calcifying cystic odontogenic tumor (CCOT), 3 cases of ameloblastic fibroma (AF), 10 cases of keratocystic odontogenic tumor (KCOT) and 2 cases of calcifying epithelial odontogenic tumor (CEOT) by in situ hybridization, and 7 cases of normal oral mucosa were selected as control. SPSS10.0 software package was used for chi(2) test.


RESULTS
HOXC13 mRNA was positively expressed in all odontogenic epithelium except AF. The positive ratios were 97.9% in AB, 100% in CCOT, 100% in CEOT, 70.0% in KCOT epithelium and 42.9% in the normal oral mucosa. There was significant difference among AB, KCOT and normal mucosa (chi(2)=21.665, P<0.001).


CONCLUSIONS
The genesis and development of odontogenic tumors are related to the high expression of HOXC13. The expression of HOXC13 mRNA in the odontogenic lesions has heterogeneity.
Hong
Yan-song
YS
Department of Oral Pathology, College of Stomatology, China Medical University, Shenyang 110002, China.
Wang
Jie
J
Liu
Jie
J
Zhang
Bo
B
Hou
Lin
L
Zhong
Ming
M
D000564:Ameloblastoma; D018398:Homeodomain Proteins / Q000096:biosynthesis*; D006801:Humans; D009061:Mouth Mucosa; D018333:Odontogenic Cyst, Calcifying / Q000378:metabolism*; D009808:Odontogenic Tumors / Q000378:metabolism*; D012333:RNA, Messenger; D012878:Skin Neoplasms / Q000378:metabolism*
D018398:Homeodomain Proteins; D012333:RNA, Messenger