title: Pregnancy, delivery and birth outcome in different stages of maternal multiple sclerosis.
abstract: To investigate the influence of maternal multiple sclerosis (MS) on pregnancy, we compared pregnancy, delivery and birth outcome in births prior to onset of MS (pre MS), between MS onset and diagnosis (early MS), and after diagnosis of MS (manifest MS). Mothers with MS were identified through linkage of the Norwegian MS Registry and the Medical Birth Registry of Norway (1967-2002). All pre MS births (n = 1910), early MS births (n = 555), and manifest MS births (n = 308) were compared. There was a significantly lower mean birth weight in term births (adjusted for gestation in weeks, mother's age, time period and caesarean section) in the manifest MS compared to the pre MS group (P = 0.046). The rate of birth complications and interventions did not differ between the three groups. Manifest MS in birth-giving mothers seems to affect birth weight.
authors.affiliation: Dept. of Clinical Medicine, University of Bergen, Bergen, Norway. julie.dahl@helse-bergen.no
authors.forename: Julie
authors.initials: J
authors.lastname: Dahl
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.forename: Anne Kjersti
authors.initials: AK
authors.lastname: Daltveit
authors.forename: Nils Erik
authors.initials: NE
authors.lastname: Gilhus
mesh_terms: D000328:Adult; D001724:Birth Weight; D002585:Cesarean Section / Q000706:statistics & numerical data; D015897:Comorbidity; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008297:Male; D008423:Maternal Age; D009103:Multiple Sclerosis / Q000453:epidemiology*; D009664:Norway / Q000453:epidemiology; D007744:Obstetric Labor Complications / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors