Primary non-gestational uterine cervical choriocarcinoma with metaplastic transformation from squamous cells.
BACKGROUND
Primary non-gestational uterine cervical choriocarcinoma is very unusual and although it has been hypothesized that it can arise by metaplastic transformation of cervical epithelium, solid evidence has been lacking.


METHODS
Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a 47-year-old, woman undergoing tubal resection 17 years previously. A histologically- and immunohistochemically-confirmed, non-gestational cervical choriocarcinoma could be diagnosed in which there was metaplastic transformation from squamous cells . The patient underwent 5 courses of an actinomycin-D chemotherapeutic regimen and radical hysterectomy with bilateral pelvic lymphadenectomy.


CONCLUSIONS
Primary non-gestational uterine cervical choriocarcinoma may indeed arise from metaplastic transformation of epithelial tissue.
Chumworathayi
Bandit
B
Kleebkaow
Pilaiwan
P
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D031954:Choriocarcinoma, Non-gestational / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008679:Metaplasia / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
D000903:Antibiotics, Antineoplastic; D003609:Dactinomycin