Protective effects of overexpression of bcl-xl gene on local cerebral infarction in transgenic mice undergoing permanent occlusion of middle cerebral artery.
In order to investigate the protective effects of the overexpression of bcl-xl gene on local cerebral infarction in the transgenic mice subject to permanent occlusion of middle cerebral artery, the models of bcl-xl transgenic mice were established and subjected to cerebral infarction by intraluminal occlusion of the middle cerebral artery. The infarct volume and the neurological scores were observed and comparison between the wild type mice and the transgenic mice was made. It was found that the infarct volume and the neurological scores in the transgenic mice were significantly decreased as compared with those in the wild type mice. It was suggested that the overexpression of bcl-xl gene in transgenic mice could reduce the infarct volume and improve the neurological function of the mice.
Wang
Furong
F
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. jys@medmail.com.cn
Jiang
Yongsheng
Y
Zhang
Suming
S
Xiao
Wenwu
W
Zhu
Suiqiang
S
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000378:metabolism; D002544:Cerebral Infarction / Q000235:genetics*; D005786:Gene Expression Regulation; D020244:Infarction, Middle Cerebral Artery / Q000235:genetics*; D007425:Intracellular Membranes / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D020768:Middle Cerebral Artery / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D013997:Time Factors; D051020:bcl-X Protein / Q000096:biosynthesis* / Q000235:genetics*
D051020:bcl-X Protein