[Research progress in epigenetics of sperm].
Epigenetics is defined as the study of the heritable phenotype change that is not strictly dependent on DNA sequence. It involves DNA methylation, histone modifications, regulations of non-coding RNAs, and so on. Great epigenetic changes take place during the spermatogenesis and fertilization, so it is very important for us to understand the epigenetic messages. This paper provides an overview of the latest researches on epigenetics of male germ cells, and briefly discusses the possible genetic risks of the assisted reproductive technology (ART).
Yang
Bin
B
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Command, PLA , Nanjing, Jiangsu 210002, China. ybdz@163.com
Xia
Xin-Yi
XY
Huang
Yu-Feng
YF
Xu
Xiao-Feng
XF
D044127:Epigenesis, Genetic; D006801:Humans; D008297:Male; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects / Q000639:trends; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism*