Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species.
Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis, but not in biofilms of Candida glabrata or Candida tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms.
Al-Dhaheri
Rawya S
RS
Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Douglas
L Julia
LJ
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D025141:Drug Resistance, Fungal; D013045:Species Specificity
D000935:Antifungal Agents; D000666:Amphotericin B