HIV type 2 intergroup recombinant identified in Cameroon.
A unique HIV-2 intergroup recombinant strain was identified in Cameroon. The virus, CM-03-510-03, was amplified from blood collected from a 47-year-old female patient in Douala, Cameroon in 2003 who was seroreactive for HIV-2. A near full-length genome 9089 nucleotides in length was amplified from proviral DNA. The genome for CM-03-510-03 is composed of segments of HIV-2 groups A and B with four recombination break-points and has open reading frames for all the structural and regulatory genes. A comparison of CM-03-510-03 to the only previously reported HIV-2 intergroup recombinant shows that the two strains share one recombination breakpoint but are otherwise distinct from each other. Similar to HIV-1, HIV-2 intergroup recombination is an indication that coinfection with more than one strain has occurred in individuals and is a mechanism that increases strain genetic diversity.
Yamaguchi
Julie
J
Abbott Diagnostics, Abbott Park, Illinois 60064, USA.
Vallari
Ana
A
Ndembi
Nicaise
N
Coffey
Ruthie
R
Ngansop
Charlotte
C
Mbanya
Dora
D
Kaptué
Lazare
L
Gürtler
Lutz G
LG
Devare
Sushil G
SG
Brennan
Catherine A
CA
D002163:Cameroon; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015498:HIV-2 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D054298:Human Immunodeficiency Virus Proteins / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D011533:Proviruses / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
D004279:DNA, Viral; D054298:Human Immunodeficiency Virus Proteins; D012367:RNA, Viral