title: Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen.
abstract: Finegoldia magna (formerly Peptostreptococcus magnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report the complete genome sequence of F. magna ATCC 29328. The genome consists of a 1,797,577 bp circular chromosome and an 189,163 bp plasmid (pPEP1). The metabolic maps constructed based on the genome information confirmed that most F. magna strains cannot ferment most sugars, except fructose, and have various aminopeptidase activities. Three homologs of albumin-binding protein, a known virulence factor useful for antiphagocytosis, are encoded on the chromosome, and one albumin-binding protein homolog is encoded on the plasmid. A unique feature of the genome is that F. magna encodes many sortase genes, of which substrates may be involved in bacterial pathogenesis, such as antiphagocytosis and adherence to the host cell. The plasmid pPEP1 encodes seven sortase and seven substrate genes, whereas the chromosome encodes four sortase and 19 substrate genes. These plasmid-encoded sortases may play important roles in the pathogenesis of F. magna by enriching the variety of cell wall anchored surface proteins.
authors.affiliation: Department of Microbiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-0012, Japan. t-goto@wakayama-med.ac.jp
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Goto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamashita
authors.forename: Hideki
authors.initials: H
authors.lastname: Hirakawa
authors.forename: Minenosuke
authors.initials: M
authors.lastname: Matsutani
authors.forename: Kozo
authors.initials: K
authors.lastname: Todo
authors.forename: Kenshiro
authors.initials: K
authors.lastname: Ohshima
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Toh
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Kuhara
authors.forename: Masahira
authors.initials: M
authors.lastname: Hattori
authors.forename: Tohru
authors.initials: T
authors.lastname: Shimizu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Akimoto
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002876:Chromosomes, Bacterial; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010462:Peptostreptococcus / Q000235:genetics* / Q000648:ultrastructure; D010957:Plasmids / Q000235:genetics
chemical_list: D001426:Bacterial Proteins