Chromatin proteomics and epigenetic regulatory circuits.
Many phenotypic changes of eukaryotic cells due to changes in gene expression depend on alterations in chromatin structure. Processes involved in the alteration of chromatin are diverse and include post-translational modifications of histone proteins, incorporation of specific histone variants, methylation of DNA and ATP-dependent chromatin remodeling. Interconnected with these processes are the localization of chromatin domains within the nuclear architecture and the appearance of various classes of noncoding regulatory RNAs. Recent experiments underscore the role of these processes in influencing diverse biological functions. However, the evidence to date implies the importance of an interplay of all these chromatin-changing functions, generating an epigenetic regulatory circuit that is still not well understood.
Bönisch
Clemens
C
Adolf-Butenandt-Institute & Center for Integrated Protein Science Munich (CIPSM), Department of Molecular Biology, Ludwig-Maximilians University, Schillerstr. 44, 80336 Munich, Germany. clemens.boenisch@med.uni-muenchen.de
Nieratschker
Sonja M
SM
Orfanos
Nikos K
NK
Hake
Sandra B
SB
D000107:Acetylation; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D018899:CpG Islands; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D007448:Invertebrates / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000032:analysis / Q000502:physiology; D009707:Nucleosomes / Q000648:ultrastructure; D010766:Phosphorylation; D010944:Plants / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods*; D022661:RNA, Untranslated / Q000235:genetics; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins; D009707:Nucleosomes; D020033:Protein Isoforms; D022661:RNA, Untranslated; D000255:Adenosine Triphosphate