title: Association of functional polymorphisms in NOS1 and NOS3 with loudness dependence of auditory evoked potentials.
abstract: Nitric oxide (NO) is a gaseous molecule with neurotransmitter properties that is involved in numerous functions in the central nervous system (CNS), the vascular system and also in macrophages. Haplotypes of NOS1 and NOS3 genes have been shown to be associated with different psychiatric disorders such as schizophrenia and bipolar disorder. Therefore, the detection of other characteristics of nitrinergic transmission is desirable. Because nitrinergic functioning influences serotonergic transmission, a functional marker of the serotonergic transmission, the loudness dependence of auditory evoked potentials (LDAEP), can be assumed to be influenced by nitrinergic changes as well. In order to clarify the relationship between nitrinergic transmission and LDAEP, 95 healthy subjects (41 males, 54 females) underwent electrophysiological recording and blood drawing for genotyping of single nucleotide polymorphisms (SNPs) and haplotypes of the NOS1 and NOS3 genes. Interestingly, two functional SNPs in both NOS1 (G-84A_exon 1c promoter polymorphism) and NOS3 (Glu298Asp) were associated with lower LDAEP. Further studies are needed to fully clarify the relationship between nitrinergic transmission, LDAEP and complex disorders such as schizophrenia and affective disorders.
authors.affiliation: Research Group Clinical and Experimental Psychopathology, Psychiatric University Hospital Zurich, Zurich, Switzerland.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Kawohl
authors.forename: Ina
authors.initials: I
authors.lastname: Giegling
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Mavrogiorgou
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
authors.forename: Christoph
authors.initials: C
authors.lastname: Mulert
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: Georg
authors.initials: G
authors.lastname: Juckel
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000235:genetics* / Q000502:physiology; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D052248:Nitric Oxide Synthase Type I / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012701:Serotonin / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D009569:Nitric Oxide; D012701:Serotonin; C496320:NOS1 protein, human; C496314:NOS3 protein, human; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III