title: New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima.
abstract: Two new cyclohexenones (antheminones A and B) and a new cyclohexanone, (antheminone C) along with five known compounds were isolated from the leaves of Anthemis maritima L. The structures were mainly deduced from extensive 1D and 2D NMR spectroscopy and mass spectrometry. The new compounds were tested in vitro for their cytotoxic activity against adherent and non-adherent cancer cell lines. Antheminones A and C exhibited significant antiproliferative activity against leukemia cells with IC(50) values ranging from 3.2 to 14 microM.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Collu
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bonsignore
authors.forename: Mariano
authors.initials: M
authors.lastname: Casu
authors.forename: Costantino
authors.initials: C
authors.lastname: Floris
authors.forename: Jürg
authors.initials: J
authors.lastname: Gertsch
authors.forename: Filippo
authors.initials: F
authors.lastname: Cottiglia
mesh_terms: D031166:Anthemis / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones; C528888:antheminone A; C528889:antheminone B; C528890:antheminone C