title: Association of albuminuria and cancer incidence.
abstract: Albuminuria, which is associated with noncardiovascular mortality, might be a result of altered vascular permeability caused by cytokines and other tumor cell products. The aim of this population-based, longitudinal study was to examine whether elevated albumin-to-creatinine ratio (ACR) is associated with cancer incidence. A total of 5425 participants without diabetes or previous cancer in the Tromsø Study were followed; 590 had a first diagnosis of cancer during 10.3 yr of follow-up. The ACR at baseline significantly correlated with the incidence of cancer, even after adjustment for age, gender, body mass index, physical activity, and smoking (P < 0.001). Participants with ACR in the highest quintile were 8.3- and 2.4-fold more likely to receive a diagnosis of bladder cancer and lung cancer, respectively, compared with those with ACR in the lowest quintile after similar adjustments. It is concluded that albuminuria is associated with cancer incidence in individuals without a history of diabetes, macroalbuminuria, or previous cancer and that it might confer risks of varying magnitude for different types of cancer.
authors.affiliation: Institute of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway. lone.jorgensen@ism.uit.no
authors.forename: Lone
authors.initials: L
authors.lastname: Jørgensen
authors.forename: Ivar
authors.initials: I
authors.lastname: Heuch
authors.forename: Trond
authors.initials: T
authors.lastname: Jenssen
authors.forename: Bjarne K
authors.initials: BK
authors.lastname: Jacobsen
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000453:epidemiology*; D001943:Breast Neoplasms / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D009664:Norway / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology