Menisporopsin B, a new polyester from the seed fungus Menisporopsis theobromae BCC 4162.
A new linear polyester, menisporopsin B, along with the known macrocyclic polyester, menisporopsin A, was isolated from the seed fungus Menisporopsis theobromae BCC 4162. The structure of menisposopsin B was addressed primarily by spectroscopic analyses, and the stereochemistry was established by chemical correlation. Menisporopsin B exhibited antimalarial activity with an IC(50) value of 1.0 microg/ml.
Ruanglek
Vasimon
V
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand.
Chokpaiboon
Supichar
S
Rattanaphan
Nakul
N
Madla
Siribhorn
S
Auncharoen
Patchanee
P
Bunyapaiboonsri
Taridaporn
T
Isaka
Masahiko
M
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013057:Spectrum Analysis
D000962:Antimalarials; D018942:Macrolides; D011091:Polyesters; C485925:menisporopsin A; C529096:menisporopsin B