title: Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk.
abstract: We examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38(-) cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns with >or=3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk.
authors.affiliation: Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Strohsnitter
authors.forename: T M
authors.initials: TM
authors.lastname: Savarese
authors.forename: H P
authors.initials: HP
authors.lastname: Low
authors.forename: D P
authors.initials: DP
authors.lastname: Chelmow
authors.forename: P
authors.initials: P
authors.lastname: Lagiou
authors.forename: M
authors.initials: M
authors.lastname: Lambe
authors.forename: K
authors.initials: K
authors.lastname: Edmiston
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: I
authors.initials: I
authors.lastname: Baik
authors.forename: K L
authors.initials: KL
authors.lastname: Noller
authors.forename: H-O
authors.initials: HO
authors.lastname: Adami
authors.forename: D
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: C-C
authors.initials: CC
authors.lastname: Hsieh
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000097:blood*; D001724:Birth Weight; D001772:Blood Cell Count; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000453:epidemiology; D012306:Risk
chemical_list: D051997:ADP-ribosyl Cyclase 1