Decreased matriptase/HAI-1 ratio in advanced colorectal adenocarcinoma of Chinese patients.
Matriptase is a serine protease expressed by tumors of surface epithelial origin. We tested the expressions of matriptase and hepatocyte growth factor activator inhibitor-1 (HAI-1) maybe associated with the progression of colorectal adenocarcinoma. Immunohistochemical analysis of matriptase and HAI-1 was performed in tissue microarray slides of 91 colorectal adenocarcinomas with various degrees. The matriptase scores in moderately (346.7 +/- 10.6) and poorly differentiated (248.1 +/- 12.9) were significantly lower than those in well differentiated (368.4 +/- 9.6) colorectal adenocarcinomas. The matriptase/HAI-1 ratios in poorly (1.8 +/- 0.4) and moderately differentiated (1.8 +/- 0.3) were significantly lower than in well differentiated (2.2 +/- 0.2) colorectal adenocarcinomas. Otherwise, the matriptase scores and matriptase/HAI-1 ratio showed significant reverse correlation with more advanced TNM stages of colorectal adenocarcinomas in Chinese patients. In conclusion, pharmacological inhibitors of matriptase may not be effective treatment for advanced colorectal adenocarcinomas.
Tsai
Wen-Chiuan
WC
Department of Pathology, Division of Gastroenterology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Sheu
Lai-Fa
LF
Chao
You-Chen
YC
Chen
Ann
A
Chiang
Hung
H
Jin
Jong-Shiaw
JS
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology*; D000368:Aged; D044466:Asian People; D002681:China; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D053491:Proteinase Inhibitory Proteins, Secretory / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism*; D015996:Survival Rate; D013997:Time Factors
D053491:Proteinase Inhibitory Proteins, Secretory; C109149:SPINT1 protein, human; D012697:Serine Endopeptidases; C485595:matriptase