Medication use in the neonatal intensive care unit: current patterns and off-label use of parenteral medications.
OBJECTIVE
To study the current patterns of medication use, assess the extent of off-label parenteral medication use, and evaluate evidence for efficacy and safety of parenteral medications used off-label in neonates.


METHODS
We collected information on all medications dispensed for infants admitted to an urban tertiary care neonatal intensive care unit over a 3-year period. Parenteral drugs were reviewed for off-label use, and medications not approved for use in neonates were evaluated for evidence of efficacy and safety in neonates.


RESULTS
The ranges of gestational age, length of stay, and number of medications per infant were 23 to 42 weeks, 1 to 190 days, and 1 to 62, respectively, for 2304 admissions during the study period. Infants with lower birth weight and shorter gestational age received more medications compared with more mature infants. Of 61 parenteral medications evaluated, 27 (45%) were used off-label in neonates. Food and Drug Administration (FDA) approval for use in neonatal period was highest for antibiotics (14/16); the parenteral medications most frequently used off-label were analgesics, vasopressors, and hematologic agents.


CONCLUSIONS
Critically ill neonates are exposed to numerous medications, a significant proportion of which are not yet FDA-approved for use in this vulnerable group of patients.
Kumar
Praveen
P
Department of Pediatrics, Northwestern Memorial Hospital and Children's Memorial Hospital, Chicago, IL, USA.
Walker
Jennifer K
JK
Hurt
Kristin M
KM
Bennett
Kimberly M
KM
Grosshans
Neal
N
Fotis
Michael A
MA
D015331:Cohort Studies; D017277:Drug Approval; D004348:Drug Labeling; D004363:Drug Utilization; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007363:Intensive Care Units, Neonatal; D008297:Male; D017063:Outcome Assessment, Health Care; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010818:Practice Patterns, Physicians'; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D014481:United States; D014486:United States Food and Drug Administration
D004364:Pharmaceutical Preparations