title: [Glaucoma neuropathy and neuropathy in multiple sclerosis--common elements of pathogenesis?].
abstract: The optic neuropathy in multiple sclerosis and glaucoma neuropathy are very common ophthalmological diseases. Multiple sclerosis /MS/ is the chronic inflammatory central nervous system demyelinisation disease with an autoimmunological ethiology. The last investigation of multiple sclerosis indicate the molecular and cellular autoimmunisation aspects. Te role of vasoactive factors is underlines in its pathogenesis which also suggests the common elements of glaucoma and MS pathogenesis. The over expressed vasoconstrictive mechanisms in both diseases can conduct to optic nerve injury. The aim of this study is evaluation of the optic disc morphological changes in sclerosis multiplex patients /MS/ with or without neuritis optica in anamnesis in glaucoma "remodeling" aspects.
  
  
  METHODS
  We present two patients with coexsist sclerosis multiplex and glaucoma neuropathy, which underwent retrobulbar neuritis.
  
  
  CONCLUSIONS
  Coexistance of glaucoma neuropathy and multiple sclerosis neuropathy may indicate common elements of glaucoma and SM pathogenesis. The authors recommend precise morphological optic disc evaluation in multiple sclerosis patients because glaucoma neuropathy may appear.
authors.affiliation: Kliniki Okulistyki Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
authors.forename: Irmina
authors.initials: I
authors.lastname: Jankowska-Lech
authors.forename: Barbara
authors.initials: B
authors.lastname: Terelak-Borys
authors.forename: Iwona
authors.initials: I
authors.lastname: Grabska-Liberek
authors.forename: Witold
authors.initials: W
authors.lastname: Palasik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019332:Endothelin-1 / Q000378:metabolism; D005901:Glaucoma / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology; D009898:Optic Disk / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009902:Optic Neuritis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011859:Radiography; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color; D014661:Vasoconstriction; D014664:Vasodilation; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D019332:Endothelin-1