title: Pulmonary thromboembolism associated with olanzapine and risperidone.
abstract: Several studies and reports suggest an increased risk of venous thromboembolism (VTE) in patients treated with conventional antipsychotic drugs, as well as with clozapine. We report the case of a 25-year-old man with early-onset schizo-affective disorder, with no identified risk factor for thromboembolism, who developed pulmonary embolism on three occasions, once shortly after initiating treatment with olanzapine and twice with risperidone. This case indicates that VTE can be associated with the use of olanzapine and risperidone, two atypical agents having similar properties and the same 5HT2 receptors antagonism, possibly implicated in this adverse event. As suggested by this observation, patients who have had one episode of VTE with antipsychotics with an affinity for 5HT2 receptors should receive neuroleptics from other classes, such as amisulpride, which does not interact with 5HT2 receptors. They should also be closely monitored to ensure early detection and prompt treatment of VTE.
authors.affiliation: Department of Psychiatry, Division of Adult Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
authors.forename: Laurence
authors.initials: L
authors.lastname: Borras
authors.forename: Ariel
authors.initials: A
authors.lastname: Eytan
authors.forename: Philippe
authors.initials: P
authors.lastname: de Timary
authors.forename: Eric-Louis
authors.initials: EL
authors.lastname: Constant
authors.forename: Philippe
authors.initials: P
authors.lastname: Huguelet
authors.forename: Cédric
authors.initials: C
authors.lastname: Hermans
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D000077152:Olanzapine; D011655:Pulmonary Embolism / Q000139:chemically induced*; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine