Exercise training in patients with stable chronic heart failure: effects on thoracic impedance cardiography and B-type natriuretic peptide.
OBJECTIVE
Recent evidence has suggested that patients with stable chronic heart failure (CHF) may respond favorably to a progressive exercise program. The use of noninvasive hemodynamic monitoring and B-type natriuretic peptide (BNP) measurement in these patients is not well reported. This study investigated the utility of noninvasive hemodynamic monitoring and point-of-care BNP in a cardiac rehabilitation outpatient setting.


METHODS
Patients with stable CHF were assigned to a supervised 12-week exercise program (n = 13) or control (n = 6). At baseline and at the end of the study period, patients were assessed for functional and quality-of-life status. Point-of-care BNP and noninvasive hemodynamic parameters were also obtained.


RESULTS
As expected, patients assigned to the exercise group showed significant improvement in quality of life and distance covered by the 6-minute walk test, but control subjects showed no such changes. There was a trend toward improved BNP in the exercise group, with 73% of these patients showing a decrease in comparison with 67% of controls showing an increase. There was a significant improvement in stroke volume in the exercise group but not in the control group.


CONCLUSIONS
Both BNP and noninvasive hemodynamic monitoring can be utilized in the cardiac rehabilitation outpatient setting and seem to mirror the favorable response to exercise of other functional tests.
Butterfield
John A
JA
Biosite Inc, Kingswood, NSW, Australia.
Faddy
Steven C
SC
Davidson
Patricia
P
Ridge
Barry
B
D015415:Biomarkers / Q000097:blood; D002307:Cardiography, Impedance; D005081:Exercise Therapy; D017079:Exercise Tolerance; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000534:rehabilitation*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011788:Quality of Life
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain