title: Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima.
abstract: Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new lignans, acutissimalignans A ( 6) and B ( 7), along with two known lignans and three known ellagic acid derivatives. The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scptc@mahidol.ac.th
authors.forename: Patoomratana
authors.initials: P
authors.lastname: Tuchinda
authors.forename: Jittra
authors.initials: J
authors.lastname: Kornsakulkarn
authors.forename: Manat
authors.initials: M
authors.lastname: Pohmakotr
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
authors.forename: Samran
authors.initials: S
authors.lastname: Prabpai
authors.forename: Chalobon
authors.initials: C
authors.lastname: Yoosook
authors.forename: Jitra
authors.initials: J
authors.lastname: Kasisit
authors.forename: Chanita
authors.initials: C
authors.lastname: Napaswad
authors.forename: Samaisukh
authors.initials: S
authors.lastname: Sophasan
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D015497:HIV-1 / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D014315:Triterpenes; C529472:acutissimalignan A; C529473:acutissimalignan B