title: Preparation and antileishmanial activity of lipophilic N-alkyl diamines.
abstract: We report in this work the preparation and the in vitro antileishmanial activity of a series of long chains N-monoalkylated diamines and two pyridinediamine derivatives. Several compounds, tested for their in vitro antiproliferative activity against Leishmania amazonensis and Leishmania chagasi, displayed a good inhibition of parasite growth, with IC(50) below 10 microM. Compounds 10 (N-dodecyl-1,2-ethanediamine), 15 (N-decyl-1,3-propanediamine) and 20 (N-dodecyl-1,4-butanediamine) were 7.3, 2.6 and 3.6 times, respectively, more active than the reference drug amphotericin B against L. chagasi promastigote forms.
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, Campos Martelos, Juiz de Fora, MG, Brazil.
authors.forename: Cristiane F
authors.initials: CF
authors.lastname: da Costa
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Coimbra
authors.forename: Fernanda G
authors.initials: FG
authors.lastname: Braga
authors.forename: Roberta C N
authors.initials: RC
authors.lastname: dos Reis
authors.forename: Adilson D
authors.initials: AD
authors.lastname: da Silva
authors.forename: Mauro V
authors.initials: MV
authors.lastname: de Almeida
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003959:Diamines / Q000737:chemistry* / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D015394:Molecular Structure
chemical_list: D000981:Antiprotozoal Agents; D003959:Diamines