title: Peripheral subretinal pigment accumulation following transpupillary thermotherapy for choroidal melanoma.
abstract: Transpupillary thermotherapy (TTT) used as either an adjunct to plaque brachytherapy or a primary treatment for choroidal melanoma can cause several intraocular complications, particularly in the retina. A 61-year-old woman had a macular choroidal melanoma measuring 8 x 7.5 X 3.6 mm and received TTT in three sessions, each 6 months apart. After the second treatment, pigmented material began to accumulate on the peripheral retina with an increasing pace. The tumor gradually regressed for 16 months, followed by a sudden regrowth. Enucleation of the eye revealed that the peripheral subretinal pigmented deposits consisted of pigment-laden macrophages and retinal pigment epithelial cells without viable tumor cells. The rare complication of peripheral subretinal pigment dispersion following TTT should not be alarming, but close monitoring is recommended.
authors.affiliation: Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
authors.forename: Hayyam
authors.initials: H
authors.lastname: Kiratli
authors.forename: Sevgül
authors.initials: S
authors.lastname: Bilgiç
authors.forename: Figen
authors.initials: F
authors.lastname: Söylemezoglu
authors.forename: Sibel
authors.initials: S
authors.lastname: Alaçal
mesh_terms: D002830:Choroid Neoplasms / Q000473:pathology / Q000628:therapy*; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D008264:Macrophages / Q000473:pathology*; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D011680:Pupil; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*