Clinical experience with exenatide in predominantly Asian and Pacific Islander patients with type 2 diabetes.
Exenatide is a new injectable medication for the treatment of hyperglycemia in type 2 diabetes. Due to limited information of exenatide use in Asians and Pacific Islanders (API), we retrospectively reviewed API patients' responses to exenatide treatment and compared the efficacy and safety of treatment to Caucasian patients. A total of 92 patients (70 API, 21 Caucasians, and 1 Hispanic) with type 2 diabetes were treated with exenatide. In all patients, there was a significant decrease in A1c level, BMI, and weight after 6 months of exenatide treatment (A1c from 8.63 +/- 1.46 to 8.23 +/- 1.46; P = 0.03, BMI from 34.54 +/- 7.07 to 32.14 +/- 6.41; P < 0.01, and weight from 215.24 +/- 52.04 to 202.50 +/- 49.90; P < 0.01 at 95% CI, N = 51). However, differences in mean change of A1c level, BMI, and weight between API and Caucasian patients were not observed at 3 and 6 months of treatment. Side effects and discontinuation of exenatide treatment between API and Caucasian patients were similar. In conclusion, exenatide is an effective anti-hyperglycemic agent in API patients with responses similar to that observed for Caucasian patients.
Chokrungvaranon
Nalurporn
N
Department of Medicine, John A. Burns School of Medicine University of Hawaii-Manoa, 677 Ala Moana Blvd, 1024 Honolulu, Hawaii 96813.
Chentanez
Teera
T
Arakaki
Richard F
RF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001208:Asia; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000208:ethnology* / Q000378:metabolism; D000077270:Exenatide; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010139:Pacific Islands; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014688:Venoms / Q000009:adverse effects / Q000627:therapeutic use*; D044465:White People
D001786:Blood Glucose; D000077270:Exenatide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D010455:Peptides; D014688:Venoms