The utility of thrombo-elastography in the monitoring of aspirin therapy.
To assess the utility of the thrombo-elastogram in monitoring of aspirin therapy 25 healthy volunteers were selected and given low-dose aspirin therapy. Thrombo-elastography and platelet aggregometry were conducted at baseline and 1 week later. After 1 week of aspirin therapy, thrombo-elastogram data failed to demonstrate a significant change in the clotting profile. Platelet aggregometry identified significant changes in the clotting profile in response to stimulation with arachidonic acid, adrenaline and ADP. We conclude that thrombo-elastography may not have utility in monitoring of response to aspirin.
Mayne
E
E
Department of Molecular Medicine and Haematology, University of the Witwatersrand and National Health Laboratory Service, Johannesburg.
Jacobson
B
B
Louw
S
S
Bernstein
P
P
Mayne
A
A
D000704:Analysis of Variance; D001241:Aspirin / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D012016:Reference Values; D015203:Reproducibility of Results; D013916:Thrombelastography / Q000706:statistics & numerical data*; D013927:Thrombosis / Q000097:blood* / Q000517:prevention & control
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin