title: Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.
abstract: Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, bacterial virulence, and drug resistance. Inhibitors of bacterial quorum sensing could therefore be useful therapeutics. Herein we report for the first time the discovery of several pyrogallol compounds as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Nanting
authors.initials: N
authors.lastname: Ni
authors.forename: Gaurav
authors.initials: G
authors.lastname: Choudhary
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008958:Models, Molecular; D015394:Molecular Structure; D011748:Pyrogallol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects*; D014733:Vibrio / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D011748:Pyrogallol