Adapting proteostasis for disease intervention.
The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era.
Balch
William E
WE
Department of Cell Biology and Institute for Childhood and Neglected Diseases, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Morimoto
Richard I
RI
Dillin
Andrew
A
Kelly
Jeffery W
JW
D000375:Aging; D000818:Animals; D002460:Cell Line; D002468:Cell Physiological Phenomena; D004358:Drug Therapy; D006706:Homeostasis; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D011487:Protein Conformation; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000627:therapeutic use; D015398:Signal Transduction
D011506:Proteins