title: [Diagnosis and quantification of iron overload in the liver using MRI].
abstract: Hereditary hemochromatosis is the most common cause of iron overload. The diagnosis of hereditary hemochromatosis has improved since Feder et al. isolated the HFE gene in 1996 and discovered the mutations related with this disease. Nevertheless, in many cases genetic tests for hereditary hemochromatosis are negative. These cases require diagnostic confirmation by quantifying the concentration of iron in the liver (LIC); this has traditionally been accomplished by liver biopsy. Many studies have shown that it is possible to quantify LIC using MRI. However, a consensus has yet to be reached about the most appropriate technique or whether it is possible to reproduce the same methods of calculation on different MRI units. This article reviews the current state of these questions and points to possible lines to standardize this noninvasive method of quantifying LIC in the future.
authors.affiliation: Osatek SA. San Sebastián. España. jmalustiza@osatek.es
authors.forename: J M
authors.initials: JM
authors.lastname: Alústiza Echeverría
authors.forename: A
authors.initials: A
authors.lastname: Castiella Eguzkiza
authors.forename: M
authors.initials: M
authors.lastname: De Juan Echávarri
authors.forename: J I
authors.initials: JI
authors.lastname: Emparanza Knorr
authors.forename: J
authors.initials: J
authors.lastname: Artetxe Okasar
authors.forename: M
authors.initials: M
authors.lastname: Uranga Uranga
authors.forename: J
authors.initials: J
authors.lastname: Echevarría Uraga
authors.forename: M
authors.initials: M
authors.lastname: Merino Hernández
authors.forename: M M
authors.initials: MM
authors.lastname: Calvo Cenizo
authors.forename: J A
authors.initials: JA
authors.lastname: Larena Iturbe
authors.forename: A
authors.initials: A
authors.lastname: Altés Hernández
mesh_terms: D002138:Calibration; D005260:Female; D006432:Hemochromatosis / Q000235:genetics; D006801:Humans; D007501:Iron / Q000032:analysis; D019190:Iron Overload / Q000175:diagnosis* / Q000235:genetics; D008099:Liver / Q000737:chemistry; D008107:Liver Diseases / Q000175:diagnosis* / Q000235:genetics; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009154:Mutation
chemical_list: D007501:Iron