title: Antifatigue effects of coenzyme Q10 during physical fatigue.
abstract: OBJECTIVE
  This study examined the effects of coenzyme Q10 administration on physical fatigue.
  
  
  METHODS
  In a double-blinded, placebo-controlled, three crossover design, 17 healthy volunteers were randomized to oral coenzyme Q10 (100 or 300 mg/d) or placebo administration for 8 d. As a fatigue-inducing physical task, subjects performed workload trials on a bicycle ergometer at fixed workloads twice for 2 h and then rested for 4 h. During the physical tasks, subjects performed non-workload trials with maximum velocity for 10 s at 30 min (30-min trial) after the start of physical tasks and 30 min before the end of the tasks (210-min trial).
  
  
  RESULTS
  The change in maximum velocity from the 30- to the 210-min trial in the 300-mg coenzyme Q10-administered group was higher than that in the placebo group. In addition, subjective fatigue sensation measured on a visual analog scale in the 300-mg coenzyme Q10-administered group after the fatigue-inducing physical task and recovery period was alleviated when compared with that in the placebo group.
  
  
  CONCLUSIONS
  Oral administration of coenzyme Q10 improved subjective fatigue sensation and physical performance during fatigue-inducing workload trials and might prevent unfavorable conditions as a result of physical fatigue.
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan. mizuno@med.osaka-cu.ac.jp
authors.forename: Kei
authors.initials: K
authors.lastname: Mizuno
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nozaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuma
authors.forename: Suzuka
authors.initials: S
authors.lastname: Ataka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tahara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sugino
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shirai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kajimoto
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kuratsune
authors.forename: Osami
authors.initials: O
authors.lastname: Kajimoto
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D001642:Bicycling / Q000502:physiology*; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects* / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10