title: Polymer-associated liposomes as a novel delivery system for cyclodextrin-bound drugs.
abstract: It is known that cyclodextrins (CDs) extract lipid components from bilayer of liposomes. This could undermine the potential benefits of liposomes as drug carriers. In this study, we demonstrated that PC-Chol liposomes with various CDs or rhapontin (Rh)-hydroxypropyl betaCD (HPbetaCD) complexes could be stabilized by association with the amphiphilic polyelectrolyte, poly(methacrylic acid-co-stearyl methacrylate). Based on the results of differential scanning calorimetry, photocorrelation spectroscopy and transmission electron microscopy, the polymer-associated liposomes had the same vesicular form as liposome with clear boundaries and retained structural integrity for at least 1 month. In addition, the polymer-associated structure was unaffected by the type of CD, the composition and concentration of lipid components, and the concentration of the Rh-HPbetaCD complex. This contrasted with PC-Chol liposomes, whose structure was dependent on these factors. Using structurally different polymer-associated liposomes and PC-Chol liposomes containing the Rh-HPbetaCD complex, we also showed that the stability of vesicles could influence the skin permeability of CD-drug complexes.
authors.affiliation: Amorepacific Corporation/R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin, 446-729, Republic of Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Lim
authors.forename: Eun Chul
authors.initials: EC
authors.lastname: Cho
authors.forename: Jongwon
authors.initials: J
authors.lastname: Shim
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: An
authors.forename: Junoh
authors.initials: J
authors.lastname: Kim
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes; D008689:Methacrylates / Q000737:chemistry*; D010316:Particle Size; D013267:Stilbenes / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D008051:Lipid Bilayers; D008081:Liposomes; D008689:Methacrylates; D013267:Stilbenes; C522565:poly(methacrylic acid-co-stearyl methacrylate); C023538:rhapontin