Proteomics and diagnostics: Let's Get Specific, again.
DNA array technology has changed all discussions about proteomics. Whole genome arrays allow unbiased experimentation, and the surprises that flow from those approaches. 'Whole proteome' proteomics is not possible today, and might never be possible unless experiments are guided by careful evaluation of reagent specificity. In this paper we explore some possible ways to increase the content of proteomic analysis.
Zichi
Dom
D
SomaLogic, 1775 38th Street, Boulder, CO 80301, USA. dzichi@somalogic.com
Eaton
Bruce
B
Singer
Britta
B
Gold
Larry
L
D000818:Animals; D000906:Antibodies / Q000276:immunology; D052158:Aptamers, Peptide / Q000378:metabolism; D003933:Diagnosis; D006801:Humans; D040081:Protein Array Analysis; D040901:Proteomics / Q000379:methods*; D012680:Sensitivity and Specificity
D000906:Antibodies; D052158:Aptamers, Peptide