Prognostic modelling in ischaemic stroke study, additional value of genetic characteristics. Rationale and design.
OBJECTIVE
The prediction of prognosis after cerebral infarction might be improved by genetic information. The aim of the Prognostic Modelling in Ischaemic Stroke study is to develop 2 different prognostic models on the basis of traditional vascular risk factors and genetic information in patients who have suffered from cerebral ischaemia of arterial origin, 1 concerning new ischaemic and the other new haemorrhagic events.


METHODS
Polymorphisms and haplotypes describing the haemostatic system and those that influence antithrombotic drug activity will be identified in a cohort of 1,200 patients with cerebral ischaemia of arterial origin who will be followed up for a mean of 6.5 years. In total, 312 ischaemic and 78 haemorrhagic events are anticipated. With a prevalence of a genetic characteristic of 10% a relative risk of 1.4 (95% confidence interval = 1.1-1.8) for ischaemic events and of 1.8 (95% confidence interval = 1.0-3.2) for haemorrhagic events can be estimated with sufficient precision. To determine the additional prognostic value of genetic characteristics the area under the ROC curves of 2 separate models will be compared: 1 based on non-genetic risk factors only, the other also including genetic data.
Achterberg
S
S
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands. s.achterberg-2@umcutrecht.nl
Kappelle
L J
LJ
Algra
A
A
D006239:Haplotypes; D006487:Hemostasis / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011379:Prognosis; D012372:ROC Curve; D012107:Research Design; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*