Metabolism of halophilic archaea.
In spite of their common hypersaline environment, halophilic archaea are surprisingly different in their nutritional demands and metabolic pathways. The metabolic diversity of halophilic archaea was investigated at the genomic level through systematic metabolic reconstruction and comparative analysis of four completely sequenced species: Halobacterium salinarum, Haloarcula marismortui, Haloquadratum walsbyi, and the haloalkaliphile Natronomonas pharaonis. The comparative study reveals different sets of enzyme genes amongst halophilic archaea, e.g. in glycerol degradation, pentose metabolism, and folate synthesis. The carefully assessed metabolic data represent a reliable resource for future system biology approaches as it also links to current experimental data on (halo)archaea from the literature.
Falb
Michaela
M
Department of Membrane Biochemistry, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Müller
Kerstin
K
Königsmaier
Lisa
L
Oberwinkler
Tanja
T
Horn
Patrick
P
von Gronau
Susanne
S
Gonzalez
Orland
O
Pfeiffer
Friedhelm
F
Bornberg-Bauer
Erich
E
Oesterhelt
Dieter
D
D019605:Euryarchaeota / Q000502:physiology*; D005492:Folic Acid / Q000096:biosynthesis*; D020745:Genome, Archaeal / Q000502:physiology*; D005990:Glycerol / Q000378:metabolism*; D010429:Pentoses / Q000378:metabolism*
D010429:Pentoses; D005492:Folic Acid; D005990:Glycerol