Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.
Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
Carvalho
A
A
School of Health Sciences, University of Minho, Braga, Portugal.
Pasqualotto
A C
AC
Pitzurra
L
L
Romani
L
L
Denning
D W
DW
Rodrigues
F
F
D000368:Aged; D001228:Aspergillosis / Q000235:genetics / Q000276:immunology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000235:genetics / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology* / Q000472:pathogenicity; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051195:Toll-Like Receptor 2 / Q000235:genetics; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D051217:Toll-Like Receptor 9 / Q000235:genetics*
C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051217:Toll-Like Receptor 9