Intake of heterocyclic aromatic amines from meat in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort.
It was the aim of the present study to estimate the intake of heterocyclic aromatic amines (HCA) from meat, which have been associated with cancer risk in several epidemiological studies, of 21 462 subjects who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) in Heidelberg. This was accomplished by using a detailed dietary questionnaire that assessed meat consumption, cooking methods, and degree of browning of the respective food items. Median total HCA intake from meat was 31 ng/d (mean 69 ng/d), which was lower than results observed in previous studies. 2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine was the most common HCA in this cohort (median 17; mean 48 ng/d). The present study offers the opportunity of a detailed examination of the associations between meat cooking as well as HCA intake from meat and cancer risk in a prospective way.
Rohrmann
Sabine
S
Division of Clinical Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. s.rohrmann@dkfz.de
Zoller
Dorothee
D
Hermann
Silke
S
Linseisen
Jakob
J
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000588:Amines / Q000032:analysis*; D003296:Cooking; D005060:Europe; D005260:Female; D006571:Heterocyclic Compounds / Q000032:analysis*; D006801:Humans; D008297:Male; D008460:Meat / Q000032:analysis*; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced*; D009749:Nutrition Surveys; D011446:Prospective Studies; D012306:Risk; D017678:Sex Distribution; D012959:Socioeconomic Factors
D000588:Amines; D006571:Heterocyclic Compounds