title: Body mass index is associated with USF1 haplotype in Korean premenopausal women.
abstract: The upstream stimulatory factor 1 (USF1) gene has been shown to play an essential role as the cause of familial combined hyperlipidemia, and there are several association studies on the relationship between USF1 and metabolic disorders. In this study, we analyzed two single nucleotide polymorphisms in USF1 rs2073653 (306A>G) and rs2516840 (1748C>T) between the case (dyslipidemia or obesity) group and the control group in premenopausal females, postmenopausal females, and males among 275 Korean subjects. We observed a statistically significant difference in the GC haplotype between body mass index (BMI) > or =25 kg/m2) and BMI <25 kg/m2 groups in premenopausal females ( chi2=4.23, p=0.04). It seems that the USF1 GC haplotype is associated with BMI in premenopausal Korean females.
authors.affiliation: Department of Internal Medicine, School of Medicine, Eulji University, Daejeon, Korea.
authors.forename: Seong-Kyu
authors.initials: SK
authors.lastname: Lee
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Byung-Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Young-Suk
authors.initials: YS
authors.lastname: Jo
authors.forename: Kang-Seo
authors.initials: KS
authors.lastname: Park
authors.forename: Haing-Woon
authors.initials: HW
authors.lastname: Baik
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Hyun
authors.forename: Je Chul
authors.initials: JC
authors.lastname: Lee
authors.forename: Soon Ae
authors.initials: SA
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017697:Premenopause; D051720:Upstream Stimulatory Factors / Q000235:genetics*
chemical_list: D008076:Cholesterol, HDL; C497181:USF1 protein, human; D051720:Upstream Stimulatory Factors