title: Does the brain become heavier or lighter after trauma?
abstract: An uncontrolled rise in intracranial pressure is probably the most common cause of death in traumatic brain-injured patients. The intracranial pressure rise is often due to cerebral oedema. Diffusion-weighted imaging has been extensively used to study cerebral oedema formation after trauma in experimental studies. Nevertheless, this technology is difficult to perform at the acute phase, especially in unstable head trauma patients. For these reasons, a safe examination allowing us to better understand the pathophysiology of cerebral oedema formation in such patients would be of great interest. Radiological attenuation is linearly correlated with estimated specific gravity in human tissue. This property gives the opportunity to measure in vivo the volume, weight and specific gravity of any tissue by computed tomography. We recently developed a software package (BrainView) for Windows workstations, providing semi-automatic tools for brain analysis from DICOM images obtained from cerebral computed tomography. In this review, we will discuss the results of the in vivo analysis of brain weight, volume and specific gravity and consider the use of this software as a new technology to improve our knowledge of cerebral oedema formation after trauma and to evaluate the severity of traumatic brain-injured patients.
authors.affiliation: Groupe hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris and Université Pierre et Marie Curie (Paris 6), Department of Anesthesiology and Critical Care, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Lescot
authors.forename: V
authors.initials: V
authors.lastname: Degos
authors.forename: L
authors.initials: L
authors.lastname: Puybasset
mesh_terms: D001812:Blood-Brain Barrier; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology*; D001929:Brain Edema / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007427:Intracranial Pressure; D009929:Organ Size; D012984:Software; D013046:Specific Gravity; D014057:Tomography, X-Ray Computed; D015599:Trauma Severity Indices; D014947:Wounds and Injuries