title: A cytoskeletal platform for local translation in axons.
abstract: Recent data indicate that local translation in growth cones is critical for axon guidance. Evidence from the Drosophila midline axon guidance system suggests that the F-actin-microtubule cross-linker Short stop (Shot) might link the translation machinery to the cytoskeleton in the growth cone. The identification of a complex of translation factors attached to the actin and microtubule networks points to a mechanism by which cytoskeletal dynamics regulate translation in axons and vice versa.
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
authors.forename: Francisca P G
authors.initials: FP
authors.lastname: Van Horck
authors.forename: Christine E
authors.initials: CE
authors.lastname: Holt
mesh_terms: D000818:Animals; D001369:Axons; D003599:Cytoskeleton / Q000502:physiology*; D004330:Drosophila; D010766:Phosphorylation; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger