title: Comparison of magnetic resonance imaging and transthoracic echocardiography for the identification of LV mass and volume regression indices 6 months after mitral valve repair.
abstract: BACKGROUND
  Magnetic Resonance Imaging (MRI) and transthoracic echocardiography have been shown to be noninvasive highly sensitive diagnostic tools to identify changes in LV mass and volume. We therefore investigated the effects of mitral valve repair (MVR) on LV function parameters including ejection fraction (EF; %), indices of LV mass (LVMI; g/m2) and volume (LVEDVI, LVESVI; mL/m2) as detected by MRI and echocardiography.
  
  
  METHODS
  Eight consecutive patients (mean age 53.3 +/- 10.0 years) with severe mitral regurgitation (MR; grade III-IV), normal LV function and sinus rhythm were included in this prospective study. Cine MRI and transthoracic M-mode echocardiography were performed pre-operatively, as well as 6 months post-op, to identify changes in EF and in LV mass and volume. Data are given as mean +/- standard deviation.
  
  
  RESULTS
  Post-op MR was grade 0-I in all patients. Early mortality and late mortality was 0%. EF by either method did not change significantly within the follow-up period. A significant improvement of indices of LV mass and volume was detected by Cine MRI and echocardiography within 6 months following surgery (LVMIMRI: pre-op: 76.3 +/- 20.1 vs. post-op: 66.5 +/- 14.3, p < 0.05; LVMIEcho: pre-op: 184.2 +/- 38.1 vs. post-op: 136.5 +/- 28.4, p < 0.05. LVEDVIMRI: pre-op: 119.3 +/- 26.0 vs. post-op: 75.4 +/- 13.1, p < 0.05; LVEDVIEcho: pre-op: 97.4 +/- 28.8 vs. post-op: 69.2 +/- 13.1, p < 0.05. LVESVIMRI: pre-op: 44.6 +/- 12.0 vs. post-op: 32.5 +/- 9.5, p < 0.05; LVESVIEcho: pre-op: 29.3 +/- 8.3 vs. post-op: 21.8 +/- 4.6, p < 0.05).
  
  
  CONCLUSIONS
  MRI and echocardiography show a significant reduction of LV volume and mass 6 months after MVR. The data show that for routine follow-up transthoracic M-mode echocardiography provides reliable information for the identification of LV mass and volume regression in patients after MVR.
authors.affiliation: Department of Cardiovascular Surgery German Heart Center Munich, Technical University of Munich, Munich, Germany. guenzinger@dhm.mhn.de
authors.forename: R
authors.initials: R
authors.lastname: Guenzinger
authors.forename: S M
authors.initials: SM
authors.lastname: Wildhirt
authors.forename: K
authors.initials: K
authors.lastname: Voegele
authors.forename: I
authors.initials: I
authors.lastname: Wagner
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
authors.forename: R
authors.initials: R
authors.lastname: Bauernschmitt
authors.forename: R
authors.initials: R
authors.lastname: Lange
mesh_terms: D000328:Adult; D000368:Aged; D003971:Diastole; D018450:Disease Progression; D004452:Echocardiography / Q000295:instrumentation; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D016896:Treatment Outcome