The biochemistry of heme biosynthesis.
Heme is an integral part of proteins involved in multiple electron transport chains for energy recovery found in almost all forms of life. Moreover, heme is a cofactor of enzymes including catalases, peroxidases, cytochromes of the P(450) class and part of sensor molecules. Here the step-by-step biosynthesis of heme including involved enzymes, their mechanisms and detrimental health consequences caused by their failure are described. Unusual and challenging biochemistry including tRNA-dependent reactions, radical SAM enzymes and substrate derived cofactors are reported.
Heinemann
Ilka U
IU
Institute of Microbiology, Technical University of Braunschweig, Spielmannstr. 7, D-38106 Braunschweig, Germany.
Jahn
Martina
M
Jahn
Dieter
D
D000622:Aminolevulinic Acid / Q000378:metabolism; D001105:Archaea / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis* / Q000737:chemistry; D006540:Herbicides; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010778:Photochemotherapy; D010944:Plants / Q000378:metabolism; D011164:Porphyrias / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D045725:Tetrapyrroles / Q000096:biosynthesis*
D006540:Herbicides; D045725:Tetrapyrroles; D006418:Heme; D000622:Aminolevulinic Acid; D012343:RNA, Transfer