title: The relationship between periodontal status and alkaline phosphatase levels in gingival crevicular fluid in men with hypergonadotropic hypogonadism.
abstract: OBJECTIVE
  The aim of this preliminary study was to determine the possible relationship between alkaline phosphatase (ALP) levels in the gingival crevicular fluid (GCF) and periodontal disease in men with hypergonadotropic hypogonadism (HH).
  
  
  METHODS
  A total of 41 patients were divided into four groups. 9 with HH and periodontitis (P/HH), 11 with HH and gingivitis (G/HH), 12 with systemically healthy and periodontally healthy (H/C) and 9 with systemically healthy and periodontitis (P/C). The clinical evaluation of patients was based on the following parameters; the plaque index (PI), gingival index (GI), probing depths (PD) and attachment level (AL). The levels of ALP in the GCF were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  No significant difference could be detected in the mean clinical parameter data between the P/HH and P/C groups (p > 0.05). The periodontitis patients in both groups (P/C and P/HH) had higher mean probing depths than the H/C and G/HH patients (p < 0.001). The concentrations and total amounts of ALP in the GCF were significantly higher in both periodontitis groups compared to healthy and gingivitis groups (p < 0.01). The serum ALP levels were significantly higher in the P/HH group when compared to the other groups (p < 0.001).
  
  
  CONCLUSIONS
  The findings of this study suggested that HH could be implicated as a contributing factor to the progress of periodontal disease.
authors.affiliation: Department of Periodontology, Gazi University, Faculty of Dentistry, Ankara, Turkey. bunsal@gazi.edu.tr
authors.forename: Berrin
authors.initials: B
authors.lastname: Unsal
authors.forename: Işil
authors.initials: I
authors.lastname: Saygun
authors.forename: Ozlem
authors.initials: O
authors.lastname: Daltaban
authors.forename: Belgin
authors.initials: B
authors.lastname: Bal
authors.forename: Erol
authors.initials: E
authors.lastname: Bolu
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000201:enzymology*; D008297:Male; D010519:Periodontium / Q000201:enzymology*
chemical_list: D000469:Alkaline Phosphatase