title: Spindle cell pseudotumor of the brain associated with Mycobacterium haemophilum and Mycobacterium simiae mixed infection in a patient with AIDS: the first case report.
abstract: BACKGROUND
  Spindle cell pseudotumors may occur due to mycobacterial infection, especially in immunocompromised hosts including those with AIDS. They have been reported from many body sites; the lymph nodes are predominantly involved, most frequently associated with Mycobacterium avium complex infection. To the best of our knowledge, Mycobacterium-associated spindle cell pseudotumors have not been previously described in the brain stem and in association with mixed mycobacterial infection.
  
  
  METHODS
  We describe a man with AIDS who presented with right hemiparesis and truncal ataxia. Magnetic resonance imaging revealed enhancing nodular lesions at the cerebral peduncle and medulla. A mycobacterial spindle cell pseudotumor was diagnosed on surgical specimens. Blood and brain tissue cultures grew Mycobacterium haemophilum and Mycobacterium simiae.
  
  
  CONCLUSIONS
  To our knowledge, this is the first case of spindle cell pseudotumor of the brain associated with M. haemophilum and M. simiae mixed infection.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Prasit
authors.initials: P
authors.lastname: Phowthongkum
authors.forename: Apatcha
authors.initials: A
authors.lastname: Puengchitprapai
authors.forename: Nibhondh
authors.initials: N
authors.lastname: Udomsantisook
authors.forename: Somying
authors.initials: S
authors.lastname: Tumwasorn
authors.forename: Chusana
authors.initials: C
authors.lastname: Suankratay
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000473:pathology*; D000328:Adult; D001927:Brain Diseases / Q000382:microbiology*; D006801:Humans; D008297:Male; D009164:Mycobacterium Infections / Q000473:pathology*; D018393:Mycobacterium haemophilum; D017966:Pyramidal Cells / Q000473:pathology*