title: Efficacy of intracameral and subconjunctival cefuroxime in preventing endophthalmitis after cataract surgery.
abstract: OBJECTIVE
  To compare the efficacy of intracameral cefuroxime versus subconjunctival cefuroxime in reducing the rate of endophthalmitis after cataract surgery.
  
  
  METHODS
  Single-specialty eye hospital, Sunderland, United Kingdom.
  
  
  METHODS
  A retrospective analysis of all presumed infectious endophthalmitis cases from January 1,2000, to December 31,2006 was performed. The rate of presumed infectious endophthalmitis in patients receiving subconjunctival cefuroxime was compared with those receiving intracameral cefuroxime at the end of surgery.
  
  
  RESULTS
  This study included 36743 phacoemulsification cataract procedures. The mean rate of presumed infectious endophthalmitis was 0.95 per 1000 cases. The incidence of endophthalmitis was higher in the subconjunctival cefuroxime group than in the intracameral cefuroxime group; the difference was statistically significant with an odds ratio of 3.01 (95% confidence interval, 1.37-6.63).
  
  
  CONCLUSIONS
  Intracameral cefuroxime was a safe alternative to subconjunctival cefuroxime and led to a lower rate of endophthalmitis.
authors.affiliation: Sunderland Eye Infirmary, University of Sunderland, Sunderland, United Kingdom.
authors.forename: Patrick
authors.initials: P
authors.lastname: Yu-Wai-Man
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Morgan
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Hildreth
authors.forename: David H
authors.initials: DH
authors.lastname: Steel
authors.forename: David
authors.initials: D
authors.lastname: Allen
mesh_terms: D000867:Anterior Chamber / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D002444:Cefuroxime / Q000008:administration & dosage*; D003228:Conjunctiva / Q000187:drug effects; D009877:Endophthalmitis / Q000453:epidemiology / Q000517:prevention & control*; D015818:Eye Infections, Bacterial / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007267:Injections; D018918:Phacoemulsification; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime