title: Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease.
abstract: OBJECTIVE
  Data regarding the nutritional status, antioxidant compounds and plasma fatty acid (FA) composition in inactive IBD are conflicting. We compared plasma levels of antioxidants and FA of patients with inactive IBD with active IBD and controls.
  
  
  METHODS
  Plasma levels of vitamin C, vitamin E, carotenoids, saturated, monounsaturated and polyunsaturated FA, inflammatory markers and nutritional status were determined after an overnight fast in 132 patients with quiescent IBD (40.6+/-13.2 years, 87F/45M), 35 patients with active disease (37.9+/-12.1 years, 25F/10M) and 45 age- and BMI-matched healthy controls (38.1+/-10.5 years, 39F/6M). Results are expressed as mean+/-SD or median [25th percentile;75th percentile].
  
  
  RESULTS
  Body mass index (BMI) was normal in inactive (23.9+/-4.7 kg/m(2)), active IBD (22.7+/-4.2 kg/m(2)) and controls (22.3+/-1.9 kg/m(2)). Compared with controls patients with quiescent IBD showed significantly decreased plasma levels of carotenoids (1.85 [1.37;2.56] vs 1.39 [0.88;1.87] micromol/L) and vitamin C (62.3 [48.7;75.0] vs 51.0 [36.4;77.6] micromol/L), increased levels of saturated FA (3879 [3380;4420] vs 3410 [3142;3989] micromol/L) and monounsaturated FA (2578 [2258;3089] vs 2044 [1836;2434] micromol/L) and similar levels of vitamin E and polyunsaturated FA. Results in active disease were similar to inactive disease.
  
  
  CONCLUSIONS
  This study shows that antioxidant status and FA profile in a larger population of IBD patients are disturbed independently from disease activity and despite normal overall nutritional status.
authors.affiliation: Charité-Universitatsmedizin Berlin, Campus Mitte, Department of Gastroenterology, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Hengstermann
authors.forename: Luzia
authors.initials: L
authors.lastname: Valentini
authors.forename: Lennart
authors.initials: L
authors.lastname: Schaper
authors.forename: Carsten
authors.initials: C
authors.lastname: Buning
authors.forename: Thomas
authors.initials: T
authors.lastname: Koernicke
authors.forename: Michaela
authors.initials: M
authors.lastname: Maritschnegg
authors.forename: Sabine
authors.initials: S
authors.lastname: Buhner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Tillinger
authors.forename: Nunzia
authors.initials: N
authors.lastname: Regano
authors.forename: Francesco
authors.initials: F
authors.lastname: Guglielmi
authors.forename: Brigitte M
authors.initials: BM
authors.lastname: Winklhofer-Roob
authors.forename: Herbert
authors.initials: H
authors.lastname: Lochs
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002338:Carotenoids / Q000097:blood; D016022:Case-Control Studies; D005227:Fatty Acids / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D008297:Male; D009752:Nutritional Status; D010084:Oxidation-Reduction; D011795:Surveys and Questionnaires; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D014815:Vitamins; D014810:Vitamin E; D002338:Carotenoids; D002097:C-Reactive Protein; D001205:Ascorbic Acid