title: Guidelines for the management of paracetamol poisoning in Australia and New Zealand--explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres.
abstract: Paracetamol is involved in a large proportion of accidental paediatric exposures and deliberate self-poisoning cases, although subsequent hepatic failure and death are both uncommon outcomes. The optimal management of most patients with paracetamol overdose is usually straightforward. However, several differing nomograms and varying recommendations regarding potential risk factors for hepatic injury introduce complexity. In order to reconcile management advice with current Australasian clinical toxicology practice, revised guidelines have been developed by a panel of clinical toxicologists consulting to the poisons information centres in Australia and New Zealand using a workshop and consultative process. This article summarises the rationale for the recommendations made in these new guidelines.
authors.affiliation: Emergency Medicine, Royal Perth Hospital, and University of Western Australia, Perth, WA, Australia. frank.daly@health.wa.gov.au
authors.forename: Frank F S
authors.initials: FF
authors.lastname: Daly
authors.forename: John S
authors.initials: JS
authors.lastname: Fountain
authors.forename: Lindsay
authors.initials: L
authors.lastname: Murray
authors.forename: Andis
authors.initials: A
authors.lastname: Graudins
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Buckley
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics / Q000506:poisoning*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics / Q000506:poisoning*; D001315:Australia; D002648:Child; D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D009520:New Zealand; D017410:Practice Guidelines as Topic
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen