title: Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics.
abstract: OBJECTIVE
  The risk of seizure early after the diagnosis of cerebral vein and dural sinus thrombosis (CVT) is not known, and the use of prophylactic antiepileptic (AED) medication in the acute phase of CVT is controversial.
  
  
  METHODS
  In a multicenter, prospective, observational study, we analyzed the risk factors for seizures experienced before the diagnosis of CVT was confirmed (presenting seizures) or within the following 2 weeks (early seizures). The risk of occurrence of early seizures was compared in 4 risk strata and related to whether patients received AEDs or not. Criteria for the strata were "presenting seizures" and "supratentorial lesions."
  
  
  RESULTS
  Two hundred forty-five of 624 (39.3%) patients with CVT experienced presenting seizures, and 43 (6.9%) patients had early seizure. In logistic-regression analysis, supratentorial lesion (odds ratio [OR]=4.05, 95% CI=2.74 to 5.95), cortical vein thrombosis (OR=2.31, 95% CI=1.44 to 3.73), sagittal sinus thrombosis (OR=2.18, 95% CI=1.50 to 3.18), and puerperal CVT (OR=2.06, 95% CI=1.19 to 3.55) were associated with presenting seizures, whereas supratentorial lesion (OR=3.09, 95% CI=1.56 to 9.62) and presenting seizures (OR=1.74, 95% CI=0.90 to 3.37) predicted early seizures. The risk of early seizures in patients with supratentorial lesions and presenting seizures was significantly lower when AED prophylaxis was used (1 with seizures in 148 patients with AEDs vs 25 in 47 patients without AEDs; OR=0.006, 95% CI=0.001 to 0.05).
  
  
  CONCLUSIONS
  CVT patients with supratentorial lesions had a higher risk for both presenting and early seizures, whereas patients with presenting seizures had a higher risk of recurrent seizures within 2 weeks. Our results support the prescription of AEDs in acute CVT patients with supratentorial lesions who present with seizures.
authors.affiliation: Department of Neurosciences and Mental Health, Hospital Santa Maria, Lisboa, Portugal. jmferro@fm.ul.pt
authors.forename: José M
authors.initials: JM
authors.lastname: Ferro
authors.forename: Patrícia
authors.initials: P
authors.lastname: Canhão
authors.forename: Marie-Germaine
authors.initials: MG
authors.lastname: Bousser
authors.forename: Jan
authors.initials: J
authors.lastname: Stam
authors.forename: Fernando
authors.initials: F
authors.lastname: Barinagarrementeria
mesh_terms: D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002550:Cerebral Veins; D015331:Cohort Studies; D004388:Dura Mater / Q000098:blood supply; D042241:Early Diagnosis; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D000927:Anticonvulsants