title: Local recurrence of tumor at sites of intervention in malignant pleural mesothelioma.
abstract: In malignant pleural mesothelioma (MPM) patients, local dissemination (LD) of the tumor is frequently observed at the sites of intervention where diagnosis/treatment are performed. We evaluate the factors affecting LD frequency and discuss the use of PR in MPM patients. Histopathologically diagnosed 212 MPM patients who had not received PR were evaluated in terms of development of LD. Of the 212 patients, 29 received supportive therapy, 157 received chemotherapy and 26 received multi-modal therapy. The LD frequency was 13.2% for all patients. The median survival rate was 9 or 10 months in patients with or without LD, respectively. A higher LD frequency was observed in patients receiving thoracotomy. The LD appearance time in supportive care is short. The LD frequency in patients treated with chemotherapy that revealed progressive disease was higher than the patients who revealed stable disease or objective response. LD developed in 2 months in patients with sarcomatous and mixed cell type, and the survival rate was low. LD was not associated with the stage of the disease. The most suitable candidate groups for PR are patients receiving supportive therapy, thoracotomy without multi-modal therapy or patients with sarcomatous and mixed cell type tumors.
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, Department of Chest Diseases, Eskisehir, Turkey. metintas@superonline.com
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Metintas
authors.forename: Guntulu
authors.initials: G
authors.lastname: Ak
authors.forename: Sebnem
authors.initials: S
authors.lastname: Parspour
authors.forename: Huseyin
authors.initials: H
authors.lastname: Yildirim
authors.forename: Sinan
authors.initials: S
authors.lastname: Erginel
authors.forename: Fusun
authors.initials: F
authors.lastname: Alatas
authors.forename: Hasan F
authors.initials: HF
authors.lastname: Batirel
authors.forename: Cumhur
authors.initials: C
authors.lastname: Sivrikoz
authors.forename: Selma
authors.initials: S
authors.lastname: Metintas
authors.forename: Emine
authors.initials: E
authors.lastname: Dundar
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010997:Pleural Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D016019:Survival Analysis; D013908:Thoracotomy / Q000009:adverse effects / Q000401:mortality