Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
Eight C-6-geranylflavonoids ( 1- 8) were isolated from an ethanol extract of Paulownia tomentosa fruits. Tomentodiplacone ( 1), 3'- O-methyl-5'-hydroxydiplacone ( 2), 3'- O-methyl-5'- O-methyldiplacone ( 3), and tomentodiplacone B ( 4) were obtained as new compounds, and 3'- O-methyldiplacol ( 5) was isolated for the first time from a natural source. The structures of these new compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy, and the absolute configurations of the compounds were determined by circular dichroism. The antibacterial activities of 1- 8 against seven bacteria and yeast were evaluated.
Smejkal
Karel
K
Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic. karel.mejkal@post.cz
Chudík
Stanislav
S
Kloucek
Pavel
P
Marek
Radek
R
Cvacka
Josef
J
Urbanová
Marie
M
Julínek
Ondrej
O
Kokoska
Ladislav
L
Slapetová
Tereza
T
Holubová
Pavla
P
Zima
Ales
A
Dvorská
Margita
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002942:Circular Dichroism; D018153:Czech Republic; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D028083:Scrophulariaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D005419:Flavonoids