The mammalian target of rapamycin pathway and its role in molecular nutrition regulation.
Mammalian target of rapamycin (mTOR) is a protein serine-threonine kinase that functions as a central element in signaling pathway involved in control of cell growth and proliferation. mTOR exists in at least two distinct multi-protein complexes, mTORC1 and mTORC2. mTOR kinase controls the translation machinery, in response to nutrients and growth factors, via activation of p70 ribosomal S6 kinase and inhibition of eukaryotic initiation factor-4E-binding protein. In this report, we review the mTOR signaling pathway and its interaction with food intake, insulin resistance, lifespan and adipogenic regulation during the molecular nutrition regulation.
Lian
Jun
J
Laboratory of Animal Molecular Nutrition, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, P.R. China.
Yan
Xiang-Hua
XH
Peng
Jian
J
Jiang
Si-Wen
SW
D000818:Animals; D002149:Energy Intake; D039603:Eukaryotic Initiation Factor-4G / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008322:Mammals; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology*; D019893:Ribosomal Protein S6 Kinases / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases
D039603:Eukaryotic Initiation Factor-4G; D011494:Protein Kinases; C546842:MTOR protein, human; D019893:Ribosomal Protein S6 Kinases; D058570:TOR Serine-Threonine Kinases; D005947:Glucose