title: Improved waveform fidelity using local HYPR reconstruction (HYPR LR).
abstract: The recently introduced HYPR (HighlY constrained backPRojection) method allows reconstruction of serial images from highly undersampled data. In HYPR, individual timeframes are obtained via unfiltered backprojections of normalized sinograms using anatomical constraints provided by a composite image. Here we develop the idea of constraining the backprojected data further to a series of local regions of interest in order to decrease the corruption of local information by distant signals. HYPR LR (local reconstruction) permits the use of a longer temporal window in the formation of the composite image, resulting in increased signal-to-noise ratio and quantitative reconstruction accuracy. Unlike HYPR, the new HYPR LR method can be applied to images acquired with arbitrary k-space trajectories. It is suitable for a broad range of medical imaging applications involving serial changes in image sequence, offering exciting new opportunities in the future.
authors.affiliation: Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53792-3252, USA. kmjohnson3@wisc.edu
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Johnson
authors.forename: Julia
authors.initials: J
authors.lastname: Velikina
authors.forename: Yijing
authors.initials: Y
authors.lastname: Wu
authors.forename: Steve
authors.initials: S
authors.lastname: Kecskemeti
authors.forename: Oliver
authors.initials: O
authors.lastname: Wieben
authors.forename: Charles A
authors.initials: CA
authors.lastname: Mistretta
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging