Salivary diagnostics: enhancing disease detection and making medicine better.
To monitor health status, disease onset and progression, and treatment outcome non-invasively is a most desirable goal in the health care delivery and health research. There are three prerequisites necessary to reach this goal: 1. A non-invasive method for collecting biological samples. 2. Specific biomarkers associated with health or disease. 3. A technology platform to rapidly discriminate the biomarkers. An initiative catalysed by the National Institute of Dental and Craniofacial Research (NIDCR) has created a roadmap to achieve this goal through the use of oral fluids as the diagnostic medium to scrutinize the health and disease status. This is an ideal opportunity to bridge state-of-the-art saliva-based biosensors and disease-discriminatory salivary biomarkers in diagnostic applications. Oral fluid, often called the mirror of the body, is a perfect medium to be explored for health and disease surveillance. The translational applications and opportunities are enormous. This review presents the translational value of saliva as a credible clinical diagnostic fluid and the scientific rationale for such use.
Segal
Alik
A
University of California-Los Angeles, School of Dentistry and Dental Research Institute, Los Angeles, CA 90095, USA. dtww@ucla.edu
Wong
David T
DT
D015415:Biomarkers / Q000032:analysis; D003933:Diagnosis; D004194:Disease; D006304:Health Status; D006801:Humans; D012463:Saliva / Q000737:chemistry*; D013674:Technology, Dental
D015415:Biomarkers