title: Antifouling metabolites from the mangrove plant Ceriops tagal.
abstract: The new diterpene methoxy-ent-8(14)-pimarenely-15-one (1) and three known metabolites: ent-8(14)-pimarene-15R,16-diol (2), stigmasterol (3) and beta-sitosterol (4), were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means of extensive NMR, IR and MS analysis. Compounds 1, 2, 3 and 4 exhibited significant antifouling activities against cyprid larvae of the barnacle Balanus albicostatus Pilsbry, with EC(50) values of 0.32 +/- 0.01, 0.04 +/- 0.00,4.05 +/- 0.15 and 18.47 +/- 0.40 microg/cm(2), respectively, whereas their toxicities towards cyprids were very low, with LC(50 )values all above 10 microg/cm(2).
authors.affiliation: Department of Biology, School of Life Sciences, Xiamen University, Xiamen 361005, PR China.
authors.forename: Jun De
authors.initials: JD
authors.lastname: Chen
authors.forename: Dan Qin
authors.initials: DQ
authors.lastname: Feng
authors.forename: Zhi Wei
authors.initials: ZW
authors.lastname: Yang
authors.forename: Zhan Chang
authors.initials: ZC
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Yi Ming
authors.initials: YM
authors.lastname: Lin
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018517:Plant Roots / Q000737:chemistry; D011522:Protons; D043982:Rhizophoraceae / Q000737:chemistry*; D016019:Survival Analysis; D001468:Thoracica / Q000187:drug effects
chemical_list: D004224:Diterpenes; D011522:Protons