Effect of pronounced weight loss on visceral fat, liver steatosis and adiponectin isoforms.
BACKGROUND
Weight loss induced by bariatric surgery is an effective method to reverse obesity and comorbidities. The aim of this prospective weight loss study was to investigate changes of body fat distribution in relation to adiponectin and its isoforms and further to investigate the influence of both body fat distribution and adiponectin on the degree of liver steatosis.


METHODS
Fifteen severely obese female patients (body mass index 43.1 +/- 4.1, mean age 34.5 +/- 8.6 years) were examined before and after surgical treatment. Grading of fatty liver disease and the subcutaneous and visceral fat diameters were determined by abdominal ultrasonography. Metabolic parameters were determined using standard methods; serum total adiponectin and its isoforms were detected by enzyme immuno assay (EIA).


RESULTS
Mean weight loss was 28.3 kg, which was mostly due to a loss in fat mass, accompanied by an increase in total adiponectin and the high molecular weight (HMW) adiponectin isoform. Visceral adipose tissue (VAT) diameter was highly correlated with liver steatosis, even more strongly than the parameters of liver function. In addition, liver steatosis correlated negatively with HMW adiponectin and binary logistic regression revealed that changes in fat mass, HMW adiponectin and alanine aminotransferase (ALT) were the best predictors for changes in the degree of hepatic steatosis.


CONCLUSIONS
Our results suggest that circulating HMW adiponectin is associated with both VAT and liver steatosis. In summary, the major findings were that the VAT diameter is highly correlated with liver steatosis, even stronger than the parameters of liver function and the association of HMW adiponectin with liver steatosis was better than with total adiponectin.
Engl
J
J
Department of Internal Medicine, Clinical Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria.
Sturm
W
W
Sandhofer
A
A
Kaser
S
S
Tschoner
A
A
Tatarczyk
T
T
Weiss
H
H
Tilg
H
H
Patsch
J R
JR
Ebenbichler
C F
CF
D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050218:Body Fat Distribution; D005234:Fatty Liver / Q000378:metabolism*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D011446:Prospective Studies; D020033:Protein Isoforms / Q000097:blood; D016896:Treatment Outcome; D015431:Weight Loss
D052242:Adiponectin; D020033:Protein Isoforms