Perspectives on articular cartilage biology and osteoarthritis.
Cartilage biochemistry and cell biology is presented in context with osteoarthritis and cartilage regeneration and repair. Success in current efforts towards cell-based orthopaedic treatment options in cases of cartilage trauma and early stages of osteoarthritic degeneration will strictly depend on strategies that rely on known mechanisms of a chondrocyte's regulation.
Mollenhauer
Juergen A
JA
Natural and Medical Sciences Institute, University of Tübingen, Germany. juergen.mollenhauer@nmi.de
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018771:Arthralgia / Q000517:prevention & control*; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000378:metabolism* / Q000503:physiopathology; D019902:Chondrocytes / Q000378:metabolism* / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal