title: FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females.
abstract: There have been several evidences that the mRNA expressions in the peripheral leukocytes may indicate not only physical but also psychological states. The purpose of this study is whether the mRNA expressional changes in the leukocytes are related to the mental states across the menstrual cycle in reproductive healthy female subjects. Thirty-eight female subjects (22.4+/-1.4 year-old) were participated in this study at three menstruation cycle periods (menstrual, follicular and luteal phase). The FKBP5 (FK506-binding protein gene), SERT (serotonin transporter gene) and COMT (catechol-o-methyltransferase gene) mRNA expressions in the leukocytes were determined with hormonal data. The psychological changes were assessed with self-rating hospital anxiety and depression scale (HADS). Only one thirds of subjects (n=12) had regular menstrual cycles during the experiment. So we analyzed the data from these 12 subjects. The anxiety score of each subject was changed across the menstrual cycle (Friedman test: P<0.05). The FKBP5 mRNA expression was significantly lower in the follicular phase than in the other phases but no changes were seen in either SERT or COMT mRNA expressions among the phases. In conclusion, there are differences of HADS anxiety score and FKBP5 mRNA expression in the leukocytes across the menstrual cycle but there is no correlation between anxiety scores and FKBP5 mRNA.
authors.affiliation: Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Kinouchi
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Iga
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Ken
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Hongwei
authors.initials: H
authors.lastname: Song
authors.forename: Satsuki
authors.initials: S
authors.lastname: Sumitani
authors.forename: Sumiko
authors.initials: S
authors.lastname: Shibuya-Tayoshi
authors.forename: Mari
authors.initials: M
authors.lastname: Haku
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
authors.forename: Kyoko
authors.initials: K
authors.lastname: Morita
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Rokutan
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D000328:Adult; D001007:Anxiety / Q000097:blood / Q000235:genetics / Q000503:physiopathology; D001008:Anxiety Disorders / Q000097:blood / Q000235:genetics / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002395:Catecholamines / Q000378:metabolism; D003863:Depression / Q000097:blood / Q000235:genetics / Q000503:physiopathology; D003866:Depressive Disorder / Q000097:blood / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005498:Follicular Phase / Q000097:blood; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008183:Luteal Phase / Q000097:blood; D008597:Menstrual Cycle / Q000502:physiology*; D011293:Premenstrual Syndrome / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D012333:RNA, Messenger / Q000032:analysis / Q000097:blood; D012016:Reference Values; D012098:Reproduction / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D015415:Biomarkers; D002394:Catechol O-Methyltransferase; D002395:Catecholamines; D012333:RNA, Messenger; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5