Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report.
BACKGROUND
Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis.


METHODS
We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor.


CONCLUSIONS
We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence.
Yamaguchi
Shigeru
S
Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. syamama1945@yahoo.co.jp
Terasaka
Shunsuke
S
Ando
Sachiko
S
Shinohara
Toshiya
T
Iwasaki
Yoshinobu
Y
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D020360:Neoadjuvant Therapy; D019635:Neurosurgical Procedures; D010954:Plasmacytoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016879:Salvage Therapy; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin