title: The role of TNF-alpha in patients with chronic low back pain-a prospective comparative longitudinal study.
abstract: OBJECTIVE
  In this prospective longitudinal clinical study with a matched-pair design, we evaluated the role of tumor necrosis factor-alpha (TNF-alpha) and its clinical relevance in patients with chronic low back pain.
  
  
  METHODS
  One hundred twenty patients with chronic low back pain were matched to a healthy control group. Patients and controls were prospectively followed for 6 months. At 4 fixed time points (day 0, day 10, day 20, and 6 mo) blood samples were taken and TNF-alpha levels compared in the 2 groups, and correlations with pain level and clinical function were analyzed.
  
  
  RESULTS
  At the beginning and at all other time points, there was a significantly higher proportion of TNF-alpha positive participants in the patients group than in the control group. The proportion of TNF-alpha positive patients decreased during the first 10 days of a multidisciplinary therapy in the patient group, but after this initial period, TNF-alpha levels remained constantly high with no further change until the final follow-up. In the healthy control group, the proportion of participants with positive TNF-alpha levels remained constant throughout the entire period. No significant correlation between TNF-alpha levels and pain or clinical function was detected.
  
  
  CONCLUSIONS
  TNF-alpha seems to have a significant role in patients with chronic low back pain. However, the pathophysiology of this process, the clinical relevance of TNF-alpha and, especially, its part in a potential therapy regimen in these patients need to be more closely examined and defined in additional studies.
authors.affiliation: Department of Orthopaedic Surgery, University Clinic of Heidelberg, Germany.
authors.forename: Haili
authors.initials: H
authors.lastname: Wang
authors.forename: Marcus
authors.initials: M
authors.lastname: Schiltenwolf
authors.forename: Matthias
authors.initials: M
authors.lastname: Buchner
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D017116:Low Back Pain / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D013223:Statistics as Topic; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D014409:Tumor Necrosis Factor-alpha