Heme oxygenase: a target gene for anti-diabetic and obesity.
Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.
Abraham
N G
NG
New York Medical College, Director of Gene Therapy, Room 527, Valhalla NY 10595, USA. NADER_ABRAHAM@NYMC.EDU
Tsenovoy
P L
PL
McClung
J
J
Drummond
G S
GS
D052242:Adiponectin / Q000097:blood; D000818:Animals; D016207:Cytokines / Q000097:blood; D003920:Diabetes Mellitus / Q000201:enzymology / Q000235:genetics / Q000517:prevention & control*; D024861:Genetic Enhancement; D051547:Heme Oxygenase-1 / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D009765:Obesity / Q000201:enzymology / Q000235:genetics / Q000517:prevention & control*; D018384:Oxidative Stress
D052242:Adiponectin; D016207:Cytokines; D051547:Heme Oxygenase-1