title: Apraxia of eyelid opening after subthalamic deep brain stimulation may be caused by reduction of levodopa.
abstract: Apraxia of eyelid opening (ALO) is an infrequent side effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD). However, the pathogenesis of ALO after STN DBS is not well understood. We report on two patients who suffered from disabling ALO after bilateral STN DBS. Their ALO improved by resuming the levodopa medication that had been discontinued after the surgery. Although ALO after STN DBS is considered as an adverse effect of STN stimulation, postoperative modification of dopaminergic medication may be a cause of ALO after STN DBS.
authors.affiliation: Department of Neurosurgery, Nagoya City University Medical School, 1 Kawasumi, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. aume@med.nagoya-cu.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Umemura
authors.forename: Takanari
authors.initials: T
authors.lastname: Toyoda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oka
authors.forename: Fumiyasu
authors.initials: F
authors.lastname: Ishii
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001072:Apraxias / Q000188:drug therapy* / Q000209:etiology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005143:Eyelids / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa