Circumdatin I, a new ultraviolet-A protecting benzodiazepine alkaloid from a marine isolate of the fungus Exophiala.
A new ultraviolet-A (UV-A) protecting benzodiazepine alkaloid, circumdatin I (1), along with the previously described circumdatin C (2) and circumdatin G (3), have been isolated from the mycelium of a marine-derived fungus of the genus Exophiala. The structures of the three circumdatins were assigned on the basis of physicochemical evidence. The absolute stereochemistry of 1 was determined by comparison of optical rotation and CD experiments with those of 2 and 3.
Zhang
Dahai
D
Department of Chemistry, Pukyong National University, Busan, Korea.
Yang
Xiudong
X
Kang
Jung Sook
JS
Choi
Hong Dae
HD
Son
Byeng Wha
BW
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001569:Benzodiazepines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005093:Exophiala / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D015394:Molecular Structure; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014466:Ultraviolet Rays
D000470:Alkaloids; D001570:Benzodiazepinones; D011837:Radiation-Protective Agents; C529286:circumdatin I; D001569:Benzodiazepines