title: Rhino-orbito-cerebral mucormycosis: report of two cases and review of the literature.
abstract: Rhino-orbito-cerebral mucormycosis (ROCM) is a rare, fulminant opportunistic fungal infection that is mostly seen in immunocompromised or diabetic patients. The disease should be recognised and treated immediately. We present here MR imaging findings of two patients with histopathologically proven ROCM. One of the cases had a history of corticosteroid treatment and iatrogenic diabetes mellitus and although amphotericin B was started immediately, the disease progressed and surgical debridement was necessary. The second case was a patient with diabetes mellitus type 1 in whom ROCM had occurred following an abdominal surgery; amphotericin B treatment alone was adequate in this patient.
authors.affiliation: University of Ankara, Faculty of Medicine, Department of Radiology, Ibni Sina Hospital, 06100 Ankara, Turkey. nurayunsal2@hotmail.com
authors.forename: N U
authors.initials: NU
authors.lastname: Haliloglu
authors.forename: Z
authors.initials: Z
authors.lastname: Yesilirmak
authors.forename: A
authors.initials: A
authors.lastname: Erden
authors.forename: I
authors.initials: I
authors.lastname: Erden
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000382:microbiology*; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D006801:Humans; D007049:Iatrogenic Disease; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis*; D009668:Nose Diseases / Q000382:microbiology*; D009894:Opportunistic Infections / Q000175:diagnosis*; D009916:Orbital Diseases / Q000382:microbiology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D000666:Amphotericin B