Hospital and 1-year outcomes of septic syndromes in older people: a cohort study.
OBJECTIVE
Our objective was to describe the relationship between sepsis syndrome mortality and cognitive and physical disability in elderly persons.


METHODS
A 1-year consecutive cohort study in clinical beds of a university hospital was performed. Variables were severity of sepsis syndrome, organ failure, functional status, age, sex, and positive cultures. Outcomes were in-hospital and 1-year mortalities.


RESULTS
The study included 137 patients (>70 years), both sexes. Data from 116 (84.5%) patients were obtainable at 1-year follow-up. Forty-eight (35%) patients presented with sepsis (11/137, 8%) or severe sepsis (37/137, 27%). In-hospital mortality was 15.3% (0% for sepsis and 21.8% if severe) and increased with organ failure (p <.0001). One-year mortality was 54.78% (63/116), mostly related to severe sepsis; predictors were severe organ failure (p <.0001), prior functional status (p =.0005), and Mini-Mental State Examination (p =.03). Prior functional status and organ failure were independent predictors.


CONCLUSIONS
In-hospital and 1-year mortality increased with septic syndrome severity, prior functional status, and organ failure.
Regazzoni
Carlos Javier
CJ
INECO, Centro de Estudios de la Memoria y Conducta, Castex 3293 (C1425CDC) Buenos Aires, Argentina. cregazzoni@intramed.net
Zamora
Rafael Jose
RJ
Petrucci
Enrique
E
Pisarevsky
Ana Andrea
AA
Saad
Ariel Karim
AK
De Mollein
Daniela
D
Luna
Carlos Marcelo
CM
Poderoso
Juan Jose
JJ
D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D016016:Proportional Hazards Models; D018746:Systemic Inflammatory Response Syndrome / Q000401:mortality*