title: Chronic kidney disease--a disease domain complex.
abstract: Chronic kidney disease (CKD) is a silent disorder that is under-recognized. It is most often diagnosed by biochemical abnormalities. The combination of age, ethnicity, gender, and serum creatinine yields the best overall index of kidney function, and the estimated glomerular filtration rate (GFR) must be readily available for clinical practitioners to facilitate identification of CKD. The detection of persistent proteinuria also heralds the presence of CKD, but this sign is often ignored. A detailed case study is presented to demonstrate the evolution of CKD and its insidious progression to a multifaceted and complex disorder. Delineation of the complications of CKD permits the adaptation of a collaborative action plan between primary care physicians and nephrologists, and sample approaches are outlined.
authors.affiliation: Wayne State University and Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Jerry
authors.initials: J
authors.lastname: Yee
mesh_terms: D000368:Aged; D019386:Alendronate / Q000627:therapeutic use; D017311:Amlodipine / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D018450:Disease Progression; D004358:Drug Therapy / Q000379:methods*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000031:analogs & derivatives / Q000627:therapeutic use; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008790:Metoprolol / Q000627:therapeutic use; D005996:Nitroglycerin / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D013876:Thiophenes / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D050071:Bone Density Conservation Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D013449:Sulfonamides; D013876:Thiophenes; D017311:Amlodipine; D000069036:Insulin Glargine; C062765:dorzolamide; D005996:Nitroglycerin; D008790:Metoprolol; D001241:Aspirin; D002118:Calcium; D019386:Alendronate