title: Diagnostic efficacy of bone scintigraphy, magnetic resonance imaging, and positron emission tomography in bone metastases of myxoid liposarcoma.
abstract: Myxoid liposarcomas (MLS) have a tendency to metastasize to unusual sites. We report an unusual case of bone metastases not detected by bone scan and neither by fluorodeoxyglucose positron emission tomography (PET-FDG) and successfully identified with magnetic resonance imaging (MRI) in a patient with metachronic MLS. Histopathological examination of the primary tumor evidenced a tumor with unfavorable prognostic markers, and the biopsy of an iliac bone lesion confirmed the diagnosis of metastatic disease. On histological grounds, the tumor showed features of a more differentiated neoplasm without foci of round cells or necrosis in the latter. MRI allowed the identification of disseminated disease compared to computed tomography (CT) and PET scans. Thus, because of the heterogeneous histological features of MLS and the biological behavior of the disease, a combined approach of FDGPET-CT and MRI, may allow a more accurate staging of soft tissue sarcomas.
authors.affiliation: Department of Radiation Oncology, Musculoskeletal Oncology Unit, Institute of Hematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. cconill@clinic.ub.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Conill
authors.forename: Xavier
authors.initials: X
authors.lastname: Setoain
authors.forename: Luis
authors.initials: L
authors.lastname: Colomo
authors.forename: Antonio
authors.initials: A
authors.lastname: Palacín
authors.forename: Andreu
authors.initials: A
authors.lastname: Combalia-Aleu
authors.forename: Jaime
authors.initials: J
authors.lastname: Pomés
authors.forename: Jordi
authors.initials: J
authors.lastname: Marruecos
authors.forename: Mauricio
authors.initials: M
authors.lastname: Vargas
authors.forename: Joan
authors.initials: J
authors.lastname: Maurel
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D012983:Soft Tissue Neoplasms / Q000473:pathology*
chemical_list: D019788:Fluorodeoxyglucose F18