[Role of vitamin D3 in arterial blood pressure control].
The basic function of vitamin D3 in human body is to maintain the calcium-phosphate homeostasis. Its metabolic function is mediated by the nuclear VDR receptor. The existance of vitamin D3 receptors outside tissues and organs which take part in calcium-phosphate metabolism has resulted in not treating it as an anti rickets agent only. Lower arterial blood pressure observed in people living in sunny areas and decrease of arterial blood pressure values after exposure to UVB radiation could confirm the relationship between vitamin D3 and hypertension. Perhaps through its influence on calcium-phosphate metabolism, RAA system, immune system, control of endocrine glands and endothelium function the vitamin D3 contributes to lowering arterial blood pressure and lessening the risk of cardiovascular disease.
Bednarski
Rafał
R
Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra i Klinika Nefrologii, Nadciśnienia Tetniczego i Chorób Wewnetrznych. nerka@nerka.cpro.pl
Donderski
Rafał
R
Manitius
Jacek
J
D001794:Blood Pressure / Q000502:physiology*; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D010758:Phosphorus / Q000097:blood; D012084:Renin-Angiotensin System
D002762:Cholecalciferol; D010758:Phosphorus; D002118:Calcium