title: A fatal case of necrotizing fasciitis due to bacterial translocation of Klebsiella oxytoca.
abstract: We report a 73-year-old man with hepatocellular cell carcinoma who had eruptions on and severe pain in the lower leg. Within several hours, the patient's skin lesions had progressed markedly. Magnetic resonance imaging findings were consistent with necrotizing fasciitis. Klebsiella oxytoca was isolated from cultures of biopsy samples taken from the leg. The resulting DNA fingerprint pattern revealed that the enteric bacterium was the same as that obtained from the biopsy samples taken from the leg. Furthermore, a dendrogram showed that genetic proximity between samples was extremely high. These results confirmed that translocation of Klebsiella oxytoca as an enteric pathogen caused the necrotizing fasciitis in this patient.
authors.affiliation: Ariake Sea Research Project, Saga University, 5-1-1 Nabeshima, Saga, Japan. ooishih@cc.saga-u.ac.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Oishi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Mitsumizo
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Genta
authors.initials: G
authors.lastname: Kobayashi
authors.forename: Kazuma
authors.initials: K
authors.lastname: Udo
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Aoki
authors.forename: Megumi
authors.initials: M
authors.lastname: Takayanagi
authors.forename: Zenzo
authors.initials: Z
authors.lastname: Nagasawa
authors.forename: Kazukuni
authors.initials: K
authors.lastname: Araki
authors.forename: Noriko
authors.initials: N
authors.lastname: Ohza
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Mikio
authors.initials: M
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D018988:Bacterial Translocation; D006528:Carcinoma, Hepatocellular / Q000150:complications*; D004269:DNA, Bacterial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D005243:Feces / Q000382:microbiology; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis*; D041121:Klebsiella oxytoca / Q000235:genetics / Q000302:isolation & purification; D007866:Leg / Q000382:microbiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012867:Skin / Q000382:microbiology; D017211:Treatment Failure
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S