title: "Click" synthesis of small-molecule inhibitors targeting caspases.
abstract: A panel of 198 P4-diversified aldehyde (reversible) and vinyl sulfone (irreversible) inhibitors is successfully synthesized via an efficient "click chemistry" platform and directly screened against caspase-3 and -7 for inhibition.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Su Ling
authors.initials: SL
authors.lastname: Ng
authors.forename: Peng-Yu
authors.initials: PY
authors.lastname: Yang
authors.forename: Kitty Y-T
authors.initials: KY
authors.lastname: Chen
authors.forename: Rajavel
authors.initials: R
authors.lastname: Srinivasan
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D061945:Caspase Inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D008970:Molecular Weight; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors; D054852:Small Molecule Libraries; D013450:Sulfones; C009873:divinyl sulfone