title: [Main regulatory factors for differentiation, development and function of naturally occurred CD4+ CD25+ regulatory T cells].
abstract: Naturally occurred CD4(+)CD25(+) regulatory T cells derived from thymus. It plays an important role in self-tolerance and allograft-tolerance through cell-contact dependent mechanism. This review described the advances of study on the probable regulatory factors of the naturally occurring regulatory T cells, such as Foxp3, IL-2, TGF-beta(1), dendritic cells and CTLA-4. As a marker of Treg, the expression of Foxp3 could be used to identify regulatory T cells. The combination of interferon 2 and IL-2Ralpha would activate Treg and promote its proliferation through the phosphorylation of STAT5. TGF-beta(1) on the cell surface may influence the function of Treg, while the secretion type of TGF-beta may promote the proliferation of Treg. Dendritic cells can positively or negatively regulate Treg, which depends on the signal transduction pathway. CTLA-4 expressed on the surface of Treg might bind to the B7 molecule on the DC, effective cell or Treg itself directly or indirectly regulate Treg.
authors.affiliation: Department of Hematology, Huashan Hospitals, Fudan University Shanghai Medical College, Shanghai 200040, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Xue
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism*; D002454:Cell Differentiation / Q000276:immunology*; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D016212:Transforming Growth Factor beta