title: Treatment of akinetic mutism with intramuscular olanzapine: a case series.
abstract: Akinetic mutism is a wakeful state of severe apathy and paucity of volitional movement. Evidence indicates a possible dopaminergic hypofunction within the anterior cingulate cortex. The authors present three cases of acute onset akinetic mutism successfully treated with intramuscular olanzapine.
authors.affiliation: Eastern Virginia Medical School, Department of Psychiatry and Behavior Sciences, 825 Fairfax Ave., Norfolk, VA 23507, USA. spiegedr@evms.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Spiegel
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Casella
authors.forename: David M
authors.initials: DM
authors.lastname: Callender
authors.forename: Neetu
authors.initials: N
authors.lastname: Dhadwal
mesh_terms: D000368:Aged; D000405:Akinetic Mutism / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001569:Benzodiazepines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000379:methods; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine