Blood and marrow transplant for lymphoma patients with HIV/AIDS.
OBJECTIVE
Important strides in the management of patients with HIV/AIDS-related lymphomas have been made in recent years. This review will discuss the role of bone marrow or peripheral stem-cell transplantation as a modality for patients with HIV and lymphoma.


RESULTS
In the era of highly active antiretroviral therapy, patients with HIV-associated lymphoma are generally being treated with standard or only slightly modified chemotherapy regimens. Autologous bone marrow and stem-cell transplant approaches in lymphoma patients have been successful. Case reports suggest that allogeneic transplantation for patients with HIV and hematologic malignancies merits further investigation.


CONCLUSIONS
High-dose hematopoietic stem-cell therapies with curative intent should be considered as standard therapeutic options in patients who otherwise are appropriate for such therapies.
Wagner-Johnston
Nina D
ND
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA.
Ambinder
Richard F
RF
D016026:Bone Marrow Transplantation; D015658:HIV Infections / Q000150:complications* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy* / Q000821:virology*