title: [Catecholamines level variation during pregnancy in women with diabetes and preeclampsia].
abstract: BACKGROUND
  In obstetrical service it is frequent to find women with acute renal failure during second trimester of pregnancy. Main causes are related to hypertensive alterations, hemorrhage, sepsis, intrinsic renal disease and some rare disorders that produce high maternal morbidity and mortality.
  
  
  OBJECTIVE
  [corrected] To evaluate changes of adrenal function in pregnancy as well as its associated repercussions in diabetic and preeclamsic patients.
  
  
  METHODS
  Prospective study in 56 patients. Groups included women with normal pregnancy, patients with diabetes type 2, and women with preeclampsia. It was requested basic exams and samples from urine of 24 h for catecholamines determinations; as well as after two months of delivery. Catecholamines were measured with Bertler immune-fluorescent procedure.
  
  
  RESULTS
  Levels of catecholamines has statistically significant difference in all groups of study during the gestation. There was high quantity in the group of patients that developed preeclampsia 4535.5 +/- 356.4 microg/24 h (p < 0.05), compared with 31.2 +/- 9.2 microg/24 h in normal pregnancy; however, those with diabetes has a trend to increas 45.6 +/- 3.7 microg/24 h, without statistical differences. Two months after pregnancy levels shown 17.1 +/- 4.9 microg/24 h in normal pregnancy group, with preeclampsia 17.2 +/- 8.7 microg/24 h, and mild permanent increase 33.8 +/- 4.7 microg/24 h in the group with diabetes (p = 0.537).
  
  
  CONCLUSIONS
  An important catecholamines elevation is related with progress or severity of preeclampsia, and could be due to less adrenal injury associated with pregnancy, and contribute to renal failure. Longer studies are necessary to evaluate this approach in renal function.
authors.affiliation: Unidad de Investigación en Enfermedades Endocrinas, Centro Médico Nacional Siglo XXI. mhernadezvalencia@prodigy.net.mx
authors.forename: Marcelino
authors.initials: M
authors.lastname: Hernández-Valencia
authors.forename: Alfredo Martín
authors.initials: AM
authors.lastname: Rivera Montes
authors.forename: Carlos
authors.initials: C
authors.lastname: Vargas López
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Páez Angulo
authors.forename: Antonio
authors.initials: A
authors.lastname: Vargas Girón
authors.forename: Arturo
authors.initials: A
authors.lastname: Zárate
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000652:urine*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000652:urine*; D011446:Prospective Studies
chemical_list: D002395:Catecholamines