title: Proteomics, nanotechnology and molecular diagnostics.
abstract: Sequencing of the human genome opened the way to the exploration of the proteome and this has lead to the identification of large numbers of proteins in complex biological samples. The identification of diagnostic patterns in samples taken from patients to aid diagnosis is in the early stages of development. The solution to many of the technical challenges in proteomics and protein based molecular diagnostics will be found in new applications of nanomaterials. This review describes some of the physical and chemical principles underlying nanomaterials and devices and outlines how they can be used in proteomics; developments which are establishing nanoproteomics as a new field. Nanoproteomics will provide the platform for the discovery of next generation biomarkers. The field of molecular diagnostics will then come of age.
authors.affiliation: Institute of Biomedical Engineering, Imperial College, London, UK.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Johnson
authors.forename: Nikolay
authors.initials: N
authors.lastname: Zhukovsky
authors.forename: Anthony E G
authors.initials: AE
authors.lastname: Cass
authors.forename: Judit M
authors.initials: JM
authors.lastname: Nagy
mesh_terms: D015415:Biomarkers / Q000032:analysis; D015180:Electrophoresis, Gel, Two-Dimensional; D015894:Genome, Human; D006801:Humans; D007118:Immunoassay; D008280:Magnetics; D053768:Metal Nanoparticles; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D053758:Nanoparticles; D049329:Nanostructures; D036103:Nanotechnology; D053770:Nanowires; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*; D045663:Quantum Dots; D020349:Surface Plasmon Resonance
chemical_list: D015415:Biomarkers