title: Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat.
abstract: An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture, yogurt and commercial drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol (3 g/kg body weight). The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanol-induced toxicity comparable to the commercial drug treatment, according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol (2 g/kg body weight, over one week) provided protection against ethanol toxicity. After the initial set of experiments, the herbal extract mixture and yogurt treatments were extended for three more weeks. When compared to the positive control, further treatment with both the herbal extract and yogurt significantly reduced liver injury and resulted in a lower grade of lipid deposition.
authors.affiliation: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: Min-Won
authors.initials: MW
authors.lastname: Baek
authors.forename: Seung-Hyeok
authors.initials: SH
authors.lastname: Seok
authors.forename: Hui-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Dong Jae
authors.initials: DJ
authors.lastname: Kim
authors.forename: Byoung-Hee
authors.initials: BH
authors.lastname: Lee
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Ahn
authors.forename: Kwang-Sei
authors.initials: KS
authors.lastname: Lim
authors.forename: Chul-Sung
authors.initials: CS
authors.lastname: Huh
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Park
mesh_terms: D029661:Alnus / Q000737:chemistry*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D029688:Brassica napus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004435:Eating; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007887:Fabaceae / Q000737:chemistry*; D005285:Fermentation; D008099:Liver / Q000473:pathology; D008297:Male; D020944:Silybum marianum / Q000737:chemistry*; D012275:Oryza / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015014:Yogurt
chemical_list: D010936:Plant Extracts; D000431:Ethanol