Ama "zinc" link between TrkB transactivation and synaptic plasticity.
While Trk receptors can be activated in a neurotrophin-independent manner through "transactivation" by GPCR ligands, its physiological significance in the brain remains unknown. Huang et al. have now identified a novel mechanism of TrkB transactivation. They show that zinc ions can transactivate TrkB independent of neurotrophins and that such a transactivation is important for mossy fiber long-term potentiation (LTP).
Nagappan
Guhan
G
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892-3714, USA.
Woo
Newton H
NH
Lu
Bai
B
D000818:Animals; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D020813:Receptor, trkB / Q000096:biosynthesis* / Q000235:genetics; D013569:Synapses / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology*; D015032:Zinc / Q000378:metabolism*
D020813:Receptor, trkB; D015032:Zinc