title: [Allogeneic peripheral blood hematopoietic stem cell transplantation for post-operatively treating acute non-lymphocytic leukemia patient complicated with renal cell carcinoma: one case report].
abstract: The aim of this study was to evaluate the safety and efficacy of allogeneic hematopoietic peripheral blood stem cell transplantation (allo-PBHSCT) for post-operative therapy of acute non-lymphocytic leukemia (ANLL) patient complicated with renal cell carcinoma (RCC). One ANLL patient complicated with RCC underwent an myeloablative HLA-identical relative allo-PBHSCT after RCC operation. The conditioning regimen consisted of total body irradiation, cyclophosphamide and cytarabine. Graft versus host disease (GVHD) prophylaxis regimen composed of cyclosporine A, myco-phenolate mofetil and short course of methotrexate. The results indicated that the patient achieved engraftment 16 days after transplantation with full donor-type chimerism detected by STR-PCR at 30 and 100 days after transplantation. No acute or chronic GVHD and any severe complication developed. As of March 2007, the patient remains without disease at follow-up of 44 months. In conclusion, allo-HSCT procedure is feasible and effective for post-operative therapy of ANLL patient complicated with RCC without severe toxicity.
authors.affiliation: Department of Hematology, The General Hospital of PLA, Beijing 100853, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhu
authors.forename: Wan-Ming
authors.initials: WM
authors.lastname: DA
authors.forename: Chun-Ji
authors.initials: CJ
authors.lastname: Gao
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Han
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
authors.forename: Jian
authors.initials: J
authors.lastname: Bo
authors.forename: Hai-jie
authors.initials: HJ
authors.lastname: Jin
authors.forename: Meng
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000601:surgery / Q000628:therapy*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011184:Postoperative Period; D014184:Transplantation, Homologous