From basic science to blockbuster drug: the discovery of Lyrica.
Silverman
Richard B
RB
Department of Chemistry, Center for Drug Discovery and Chemical Biology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA. Agman@chem.northwestern.edu
D000700:Analgesics / Q000737:chemistry / Q000266:history* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000737:chemistry / Q000266:history* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical / Q000266:history*; D002986:Clinical Trials as Topic / Q000266:history; D049673:History, 20th Century; D006801:Humans; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000266:history / Q000627:therapeutic use
D000700:Analgesics; D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid