Changes in miRNA expression in solid tumors: an miRNA profiling in melanomas.
In this review, we briefly described microRNA biogenesis, function and the principal approaches for studying the function of microRNAs (miRNA) in solid cancers. There are currently hundreds of confirmed miRNAs in humans, and computational predictions suggest that the total count might be more than thousand. The regulatory nature of miRNAs combined with the large number of presumptive target genes suggests that they are essential regulators of a wide range of cellular processes. To illustrate the importance of miRNA-mediated regulation in solid cancer some confirmed interactions were collected. Their relevance is described in detail in melanomas from the aspect of diagnosis, the potential application of miRNAs as biomarkers and as potential therapeutic tools.
Molnár
Viktor
V
Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvárad tér, H-1089 Budapest, Hungary.
Tamási
Viola
V
Bakos
Beáta
B
Wiener
Zoltán
Z
Falus
András
A
D016543:Central Nervous System Neoplasms / Q000235:genetics; D004701:Endocrine Gland Neoplasms / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics*; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D012142:Respiratory Tract Neoplasms / Q000235:genetics; D014565:Urogenital Neoplasms / Q000235:genetics
D035683:MicroRNAs