Fluoroquinolone-resistant uropathogenic Escherichia coli in Norway: evidence of clonal spread.
Prevalence, resistance profiles, virulence gene complements, and phylogenetic and clonal affinities of fluoroquinolone-resistant Escherichia coli from urinary tract infections (UTIs) in Norway were investigated. Of 7302 E. coli UTI isolates from 2003, 1.2% were fluoroquinolone-resistant; 35 of these fluoroquinolone-resistant isolates were included in the present study. The isolates were predominantly multiresistant, carried few virulence factors, and tended to belong to the less-virulent phylogroups A and B1. Although the isolates were genetically heterogeneous, there was evidence of a limited degree of clonal dissemination.
Grude
N
N
Department of Medical Microbiology, Telemark Biomedical Centre, Skien, Norway. nils.grude@telelab.no
Strand
L
L
Mykland
H
H
Nowrouzian
F L
FL
Nyhus
J
J
Jenkins
A
A
Kristiansen
B-E
BE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D009664:Norway / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology*; D037521:Virulence Factors / Q000235:genetics
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D037521:Virulence Factors