Effects of Radix scutellariae and Rhizoma atractylodis on LPS-induced abortion and the uterine IL-10 contents in mice.
In the present study, lipopolysaccharide (LPS) was injected i.v. via the tail vein (0.1 microg per mouse) to induce abortion (embryo resorption) in Kunming mice. The interleukin 10 (IL-10) contents in the uterus were assayed by ELISA. The results revealed that the IL-10 level was significantly decreased in the LPS-induced abortion group of mice compared to the controls. Use of Pentoxifylline (PXF), or a combination of Radix scutellariae and Rhizoma atractylodis reversed the LPS effects: bringing down the fetal resorption rate, and increasing the IL-10 level significantly. The study indicates that the anti-abortive effects of PXF and the combination of Radix scutellariae and Rhizoma atractylodis are closely related to up-regulation of the Th2 cytokine IL-10 at the maternal fetal interface.
Zhong
Xiu-Hui
XH
College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding City 071001, China. zhongxiuhui@263.net
Shi
Wan-Yu
WY
Ma
Ai-Tuan
AT
Gong
Xin-Cheng
XC
Zhai
Xiang-He
XH
Zhang
Tie
T
Wang
Xiao-Dan
XD
D000019:Abortifacient Agents / Q000633:toxicity*; D000028:Abortion, Induced / Q000379:methods / Q000706:statistics & numerical data; D000818:Animals; D029064:Araceae; D020964:Embryo Loss / Q000503:physiopathology; D005260:Female; D016753:Interleukin-10 / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D029626:Ranunculaceae; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D000019:Abortifacient Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D016753:Interleukin-10