Chloropupukeananin, the first chlorinated pupukeanane derivative, and its precursors from Pestalotiopsis fici.
Chloropupukeananin (1), the first pupukeanane chloride with highly functionalized tricyclo-[4.3.1.03,7]-decane skeleton and its possible biosynthetic precursors iso-A82775C (2) and pestheic acid (3), have been isolated from the plant endophyte Pestalotiopsis fici. The structure of 1 was determined by NMR spectroscopy and X-ray crystallography. Biogenetically, 1 could be derived from the Diels-Alder adduct of 2 and 3.
Liu
Ling
L
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China.
Liu
Shuchun
S
Jiang
Lihua
L
Chen
Xulin
X
Guo
Liangdong
L
Che
Yongsheng
Y
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015497:HIV-1 / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019469:Indinavir / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry*
D019380:Anti-HIV Agents; D006843:Hydrocarbons, Chlorinated; D012717:Sesquiterpenes; C529542:chloropupukeananin; D019469:Indinavir