title: Fusarielin A as an anti-angiogenic and anti-proliferative agent: basic biological characterization.
abstract: Fusarielin A shows anti-angiogenic activity in the human umbilical vein endothelial cell (HUVEC) tube formation assay. Structural development studies indicated the importance of the hydroxyl groups in this molecule. A 3H-labeled derivative and a fluorescent affinity-labeling agent were prepared and used to examine the cellular distribution and biological behavior of fusarielin A.
authors.affiliation: Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoyama
authors.forename: Tomomi
authors.initials: T
authors.lastname: Noguchi-Yachide
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D001236:Aspergillus oryzae / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003374:Coumarins / Q000737:chemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D005456:Fluorescent Dyes; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D019920:Photoaffinity Labels; D013172:Spores, Fungal / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D003374:Coumarins; D004852:Epoxy Compounds; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D009281:Naphthalenes; D019920:Photoaffinity Labels; C092174:fusarielin A; C030123:coumarin