Mechanisms of venous thrombosis and resolution.
Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies.
Wakefield
Thomas W
TW
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. thomasww@umich.edu
Myers
Daniel D
DD
Henke
Peter K
PK
D000818:Animals; D015815:Cell Adhesion Molecules / Q000187:drug effects / Q000378:metabolism; D003018:Clot Retraction / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D051379:Mice; D019007:P-Selectin / Q000378:metabolism*; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000503:physiopathology*
D015815:Cell Adhesion Molecules; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors