title: Exposure-response in occupational allergy.
abstract: OBJECTIVE
  This review examines the relationship between exposure to workplace allergens and the risk of developing occupational allergy.
  
  
  RESULTS
  Evidence suggests that the risk of developing occupational allergy increases with allergen exposure; however, with some occupational allergens, this exposure-response relationship is more complex. In laboratory animal workers, the risk of developing occupational allergy increases with exposure, except at high allergen exposure when there is a reduction in sensitization. This attenuation of specific immunoglobulin E antibody is associated with increased specific immunoglobulin G4 antibodies, which are likely to play a protective role, leading to a form of natural tolerance. Exposure-response relationships are also very dependent on the genetic susceptibility of the individual. The interaction between genes, occupational allergens and other cofactors in the environment, such as endotoxin, are also important risk factors in the development of sensitization and asthma.
  
  
  CONCLUSIONS
  Occupational allergy provides a good opportunity to understand the complex relationships between exposure to allergens in the workplace, interaction with genes and the coexposures with other factors in the working environment and the increased risk of developing occupational allergy.
authors.affiliation: Department of Occupational and Environmental Medicine, Imperial College, 1B Manresa Road, London, UK. meinir.jones@imperial.ac.uk
authors.forename: Meinir G
authors.initials: MG
authors.lastname: Jones
mesh_terms: D000485:Allergens / Q000276:immunology; D017750:Animal Technicians; D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D004198:Disease Susceptibility / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D008452:Maximum Allowable Concentration; D016273:Occupational Exposure / Q000009:adverse effects* / Q000517:prevention & control; D012130:Respiratory Hypersensitivity / Q000235:genetics* / Q000276:immunology* / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D000485:Allergens; D007073:Immunoglobulin E