Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome.
This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.
Saltevo
Juha
J
Department of Internal Medicine, Central Hospital of Middle Finland, 40620 Jyväskylä, Finland. juha.saltevo@ksshp.fi
Vanhala
Mauno
M
Kautiainen
Hannu
H
Kumpusalo
Esko
E
Laakso
Markku
M
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007249:Inflammation; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D012680:Sensitivity and Specificity
D052242:Adiponectin; D015415:Biomarkers; D053590:Interleukin 1 Receptor Antagonist Protein; D002097:C-Reactive Protein