title: Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra) use.
abstract: Sildenafil citrate (Viagra) is one of the frequently prescribed drugs for men with erectile dysfunction. We describe a 52-year-old man with bilateral middle cerebral artery (MCA) territory infarction after sildenafil use. He ingested 100 mg of sildenafil and about 1 h later, he complained of chest discomfort, palpitation and dizziness followed by mental obtundation, global aphasia and left hemiparesis. Brain magnetic resonance imaging documented acute bilateral hemispheric infarction, and cerebral angiography showed occluded bilateral MCA. Despite significant bilateral MCA stenosis and cerebral infarction, systemic hypotension persisted for a day. We presume that cerebral infarction was caused by cardioembolism with sildenafil use.
authors.affiliation: Department of Neurology, Pochon CHA University College of Medicine, Seongnam-si, Gyeunggi-do, South Korea.
authors.forename: K-K
authors.initials: KK
authors.lastname: Kim
authors.forename: D G
authors.initials: DG
authors.lastname: Kim
authors.forename: Y H
authors.initials: YH
authors.lastname: Ku
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
authors.forename: W-C
authors.initials: WC
authors.lastname: Kim
authors.forename: O J
authors.initials: OJ
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
mesh_terms: D002533:Cerebral Angiography / Q000379:methods; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate