title: Neisseria meningitidis strains from patients with invasive meningococcal disease differ in stimulation of cytokine production.
abstract: Cytokine production was determined in vitro after stimulation with three different Neisseria meningitidis (NM) strains. Virulent NM B strain isolated from a patient with mild course of invasive meningococcal disease (IMD) elicited higher cytokine production than NM B and NM C hypervirulent strains isolated from patients with moderate and fatal course of IMD, respectively. Endotoxin concentration after in vitro stimulation correlated with cytokine production: the highest endotoxin levels were observed with virulent NM B strain. Serum cytokines and endotoxin levels showed an opposite trend. These results suggest that inflammatory response during IMD is predominantly influenced by host factors.
authors.affiliation: 3rd Department of Infectious and Tropical Diseases, 1st Faculty of Medicine, Charles University in Prague, Prague, Czechia. michal.holub@lf1.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Holub
authors.forename: M
authors.initials: M
authors.lastname: Scheinostová
authors.forename: O
authors.initials: O
authors.lastname: Dzupová
authors.forename: A
authors.initials: A
authors.lastname: Fiserová
authors.forename: O
authors.initials: O
authors.lastname: Beran
authors.forename: J
authors.initials: J
authors.lastname: Kalmusová
authors.forename: M
authors.initials: M
authors.lastname: Musilek
authors.forename: P
authors.initials: P
authors.lastname: Krízová
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D004731:Endotoxins / Q000097:blood; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D008585:Meningitis, Meningococcal / Q000276:immunology* / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D014774:Virulence
chemical_list: D016207:Cytokines; D004731:Endotoxins; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides