title: Gradenigo's syndrome.
abstract: The syndrome of constant otorrhea, headache, and diplopia, which is attributed to inflammation of the petrous apex, is known as Gradenigo's syndrome. It is often the result of chronic otitis media with long-standing purulent otorrhea. It has traditionally been treated surgically, but recent advances in imaging, allied with improved antibiotic treatment, have allowed for consideration of non-surgical management of these cases. A 60-year-old woman presented to the emergency department with 7 days of right-sided headache, facial pain, and diplopia. She awoke with the headache and facial pain 7 days earlier. She was without any preceding infectious symptoms including ear pain, sinus congestion, sore throat, and cough, and she denied fevers and chills. Examination demonstrated a right eye lateral gaze palsy and reproducible diplopia. Computed tomography studies demonstrated the possibility of fluid in the petrous apex of the temporal bone. A follow-up magnetic resonance imaging study confirmed a moderate amount of fluid in the right petrous apex consistent with Gradenigo's syndrome. Imaging with computed tomography and magnetic resonance is an important tool in the evaluation of petrous apex lesions. Gradenigo's syndrome is a rare condition that does not always present with the classical triad of otorrhea, headache, and diplopia. Appropriate management requires antibiotic treatment and possible surgical intervention.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Medical Center, San Diego, California, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Tornabene
authors.forename: Gary M
authors.initials: GM
authors.lastname: Vilke
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004172:Diplopia / Q000209:etiology*; D005260:Female; D006261:Headache / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013577:Syndrome; D013701:Temporal Bone / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents