title: Genetics, clinical manifestations and management of FAP and HNPCC.
abstract: Colorectal cancer occurs in the familial cancer syndromes in about 2 to 4 percent. The major genetic syndromes are Familial adenomatous polyposis (FAP) and Hereditary nonpolyposis colorectal cancer (HNPCC). FAP is caused by germline mutation of APC gene, and HNPCC is caused by germline mutation in one of five MMR genes. The identification of patients with inherited disease is very important in the management of colorectal cancer. But, it is impractical to test every patient with the disease for these mutations. The clinical and genetical screening programme should be advised for family members at risk and colectomy in affected individuals in purpose to reduce the frequency of colorectal cancer.
authors.affiliation: Gastroenterology Department, Clinic of Internal Diseases, University Clinical Center Tuzla, Bosnia and Herzegovina. dupavlov@bih.net.ba
authors.forename: Nada
authors.initials: N
authors.lastname: Pavlovic-Calic
authors.forename: Kasim
authors.initials: K
authors.lastname: Muminhodzic
authors.forename: Muharem
authors.initials: M
authors.lastname: Zildzic
authors.forename: Midhat
authors.initials: M
authors.lastname: Smajic
authors.forename: Adnan
authors.initials: A
authors.lastname: Gegic
authors.forename: Ervin
authors.initials: E
authors.lastname: Alibegovic
authors.forename: Nermin
authors.initials: N
authors.lastname: Salkic
authors.forename: Predrag
authors.initials: P
authors.lastname: Jovanovic
authors.forename: Mirela
authors.initials: M
authors.lastname: Basic
authors.forename: Samra
authors.initials: S
authors.lastname: Iljazovic
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans