title: Neonatal outcome and two-year follow-up after expectant management of second trimester rupture of membranes.
abstract: OBJECTIVE
  To assess neonatal outcome and 2-year follow-up of pregnancies complicated by second trimester preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  A retrospective review of obstetric and neonatal records for 87 pregnancies (56 singletons, 6 twins, 1 triplet) with PPROM between 14+0 and 24+6 weeks of gestation. Patients received antibiotics and steroids for fetal lung maturity once they reached 24 weeks of gestation. Placentas were examined histopathologically. Surviving infants were followed-up at 2 years of age.
  
  
  RESULTS
  Median latency from PPROM to delivery was 4 days. Survival rate of 56 singletons was 45% (25/56); and 13 died in hospital. Survival rate of infants discharged from hospital was 23% (12/56). Chorioamnionitis was seen histologically in 42% (5/12) of surviving infants compared with 92% (12/13) of those that died in hospital. Of the 12 surviving infants, 50% had a normal neurological and developmental outcome at 2 years of age.
  
  
  CONCLUSIONS
  Gestational age, birth weight, and histologic chorioamnionitis have prognostic importance in pregnancies complicated by PPROM. Surviving infants have a 50% chance of achieving an adequate health status at 2 years of age.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria. gunda.pristauz@klinikum-graz.at
authors.forename: Gunda
authors.initials: G
authors.lastname: Pristauz
authors.forename: Margit
authors.initials: M
authors.lastname: Bauer
authors.forename: Ute
authors.initials: U
authors.lastname: Maurer-Fellbaum
authors.forename: Christa
authors.initials: C
authors.lastname: Rotky-Fast
authors.forename: Arnim A
authors.initials: AA
authors.lastname: Bader
authors.forename: Josef
authors.initials: J
authors.lastname: Haas
authors.forename: Uwe
authors.initials: U
authors.lastname: Lang
mesh_terms: D000305:Adrenal Cortex Hormones; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002821:Chorioamnionitis / Q000188:drug therapy; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis / Q000628:therapy*; D005325:Fetal Organ Maturity / Q000187:drug effects; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000401:mortality*; D008499:Medical Records; D007752:Obstetric Labor, Premature / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents