Role of HLA B27 in diagnosis of seronegative spondyloarthropathies.
Seronegative Spondyloarthropathies (SSA) is a very common problem in our area. The main aim of present study was (1) to find the HLA B27 positivity in patients presenting with sacroileitis (2) to see the correlation of B27 positivity on haematological, radiological and extra articular manifestations. Total 110 patients of SSA were studied between July 2004 to June 2005. Routine haematological and immunological test were done by standard method. Total positivity of B27 in SSA was 43.63%, HLA B27 positivity was higher in children (68.75%). Sex wise analysis of B27 positive cases showed that 81.81% B27 positive patients were males. In HLA B27 positive cases lower spine, hip, sacroiliac, shoulder and knee joints were more involved (77.08%, 79.16%, 79.16%, 37.50% and 50.00% respectively). Urinary tract infection (UTI), diarrhoea and constipation were more common in B27 positive cases. Leukocytosis of neutrophilic type (33.33%), raised ESR (77.55%)., CRP positivity (63.63%) and anaemia (65.00%) were seen more frequently in B27 positive cases. In bilateral sacroiliitis diagnosed by X-ray, only 69.23% patient were B27 positive. Our study concludes that HLA B 27 positivity is higher in SSA seen in childhood and in young adult males. B27 positive patients have more severe disease and systemic manifestation Hence, male patients specially young adolescent or young adults with sacroileitis must be subjected for B27 typing.
Sonkar
Gyanendra Kumar
GK
UGC Advanced Immunodiagnostic Training and Research Center, Department of Pathology, IMS, BHU, Varanasi.
Usha
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016918:Arthritis, Reactive / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D002648:Child; D003248:Constipation / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D007592:Joint Diseases / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D007964:Leukocytosis; D008297:Male; D008875:Middle Aged; D012446:Sacroiliac Joint / Q000473:pathology*; D012737:Sex Factors; D013122:Spinal Diseases / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology
D015796:HLA-B27 Antigen