[Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder].
BACKGROUND
Gallbladder adenomas are infrequent neoplasms whose relation to adenocarcinoma is not well understood. It has been suggested that adenomas and adenocarcinomas follow different molecular pathways.


METHODS
This is a comparative, cross-sectional study in which we compared p53 and D1 cyclin expression in adenomas and adenocarcinomas of the gallbladder.


RESULTS
We included 12 cases in each group. Expression of p53 occurred in 83.3% of adenocarcinomas and in 16.6% of adenomas (p = 0.003). D1 cyclin was expressed in a similar number of adenomas and adenocarcinomas.


CONCLUSIONS
Our results support the hypothesis that p53 is an important step in the pathogenesis of adenocarcinomas but not of adenomas of the gallbladder. D1 cyclin is apparently a common pathway involved in the genesis of both tumors.
Arévalo
F
F
Instituto de Anatomía Patológica y Biológica Molecular Arias Stella, Universidad Nacional Mayor, Lima, Perú. fer13013@hotmail.com
Arias Stella
C
C
Monge
E
E
D000236:Adenoma / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D003430:Cross-Sectional Studies; D019938:Cyclin D1 / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005706:Gallbladder Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1