title: In vitro activity of daptomycin against multidrug-resistant Staphylococcus aureus and S. aureus with known virulence factors, including community-acquired methicillin-resistant isolates.
abstract: The in vitro activity of daptomycin was evaluated against 360 multidrug-resistant Staphylococcus aureus isolates (including hospital-acquired isolates) and multidrug-susceptible community-acquired methicillin-resistant S. aureus with known virulence genes. All isolates were inhibited at <or=1 microg/mL, suggesting that daptomycin has excellent activity against both hospital-acquired and community-acquired S. aureus isolates.
authors.affiliation: Cubist Pharmaceuticals Inc., Lexington, MA 02421, USA. diane.anastasiou@cubist.com
authors.forename: Diane M
authors.initials: DM
authors.lastname: Anastasiou
authors.forename: Margie
authors.initials: M
authors.lastname: Morgan
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ruane
authors.forename: Judith N
authors.initials: JN
authors.lastname: Steenbergen
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Katz
authors.forename: Jeff D
authors.initials: JD
authors.lastname: Alder
authors.forename: Grace M
authors.initials: GM
authors.lastname: Thorne
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology; D017576:Daptomycin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D037521:Virulence Factors / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors; D017576:Daptomycin