Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow.
OBJECTIVE
In this study, we aimed to investigate the relationship between T-786C polymorphism of the endothelial nitric oxide synthase (eNOS) gene and slow coronary flow (SCF).


METHODS
A total of 56 patients with SCF but otherwise normal coronary arteries (mean age 48+/-9 years) and 37 controls with normal coronary angiograms (mean age 50+/-12 years) were enrolled in the study. Screening for the eNOS T-786C polymorphism was performed by restriction fragment length polymorphism methodology.


RESULTS
In normal coronary artery and SCF groups, TT genotype frequency was 23 (62.2%) versus 22 (39.3%), TC heterozygote genotype frequency was 11 (29.7%) versus 30 (53.6%), and CC homozygote genotype frequency was 3 (8.1%) versus 4 (7.1%), respectively (P=0.07). In dominant model statistical analysis, total CC and CT genotype frequency in control and study groups was found to be 14 (37.3%) versus 34 (60.7%), respectively (P=0.025). A positive correlation was found between the mean thrombolysis in myocardial infarction frame count and C allele in patients with SCF (r=0.21, P=0.043).


CONCLUSIONS
We concluded that the T-786C polymorphism of eNOS gene might be a risk factor for the SCF.
Nurkalem
Zekeriya
Z
Siyami Ersek Cardiovascular and Thoracic Surgery Center, Training and Research Hospital, Istanbul, Turkey. zeknurkalem@yahoo.com
Tangurek
Burak
B
Zencirci
Ertugrul
E
Alper
Ahmet T
AT
Aksu
Huseyin
H
Erer
Betul
B
Gorgulu
Sevket
S
Ciloglu
Figen
F
Eren
Mehmet
M
D000328:Adult; D016022:Case-Control Studies; D017023:Coronary Angiography; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III