Genes and structure of selected cytokines involved in pathogenesis of psoriasis.
Psoriasis is a common skin disease involving 1-4% of human population worldwide, of strong genetic background. The following cytokines are directly involved in psoriasis: TNF, IL-1, IL-2, IL-6, IL-7, IL-8, IL-15, IL-18, IL-19, IL-20, IL-23 whereas IL-4, IL-10, IL-12 as well as IL-11, IL-17 and IFN-gamma are rather indirectly engaged. This work is a review of some genetic factors and structure of selected cytokines and receptors and their genes location.
Pietrzak
Aldona
A
Department of Dermatology, Medical University of Lublin, Poland.
Zalewska
Anna
A
Chodorowska
Grazyna
G
Nockowski
Piotr
P
Michalak-Stoma
Anna
A
Osemlak
Paweł
P
Krasowska
Dorota
D
D000818:Animals; D016207:Cytokines / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D011565:Psoriasis / Q000235:genetics* / Q000473:pathology*; D018121:Receptors, Cytokine / Q000737:chemistry / Q000235:genetics
D016207:Cytokines; D018121:Receptors, Cytokine