Histiocyte-rich reactive lymphoid hyperplasia of the liver: unusual morphologic features.
Reactive lymphoid hyperplasia (RLH) of the liver is a rare entity and has also been termed nodular lymphoid lesion or pseudolymphoma of the liver. We report a case of hepatic RLH exhibiting unusual histiocyte-rich histologic features in a 47-yr-old woman in conjunction with a renal cell carcinoma. A follow-up computed tomography scan was done 14 months after a right radical nephrectomy for renal cell carcinoma revealed a nodular lesion in segment 5 of the liver. The lesion was interpreted as metastatic renal cell carcinoma or hepatocellular carcinoma based on the history of the patient and radiologic findings. Wedge resection of segment 5 was done with sufficient distance from the mass. Microscopically, the lesion was composed predominantly of peculiar histiocytic proliferation and was characterized by lymphoid aggregates forming a lymphoid follicle with germinal centers. The present case and prior cases reported in the literature suggest that RLH of the liver appear to be a heterogenous group of reactive inflammatory lesions that are often associated with autoimmune disease or malignant tumors.
Park
Ho Sung
HS
Department of Pathology, Chonbuk National University, Medical School, Institute for Medical Sciences and the Center for Healthcare Technology Development, Jeonju, Korea.
Jang
Kyu Yun
KY
Kim
Young Kon
YK
Cho
Baik Hwan
BH
Moon
Woo Sung
WS
D002292:Carcinoma, Renal Cell / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D008875:Middle Aged; D019310:Pseudolymphoma / Q000473:pathology*