title: Migratory neighbors and distant invaders: tumor-associated niche cells.
abstract: The cancer environment is comprised of tumor cells as well as a wide network of stromal and vascular cells participating in the cellular and molecular events necessary for invasion and metastasis. Tumor secretory factors can activate the migration of host cells, both near to and far from the primary tumor site, as well as promote the exodus of cells to distant tissues. Thus, the migration of stromal cells and tumor cells among specialized microenvironments takes place throughout tumor and metastatic progression, providing evidence for the systemic nature of a malignancy. Investigations of the tumor-stromal and stromal-stromal cross-talk involved in cellular migration in cancer may lead to the design of novel therapeutic strategies.
authors.affiliation: Department of Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA.
authors.forename: Jared
authors.initials: J
authors.lastname: Wels
authors.forename: Rosandra N
authors.initials: RN
authors.lastname: Kaplan
authors.forename: Shahin
authors.initials: S
authors.lastname: Rafii
authors.forename: David
authors.initials: D
authors.lastname: Lyden
mesh_terms: D002465:Cell Movement; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology