title: Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle.
abstract: The aim of this study was to determine whether single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle. By direct DNA sequencing in 24 unrelated Korean native cattle, we identified 20 SNPs in FABP3 and FABP4. Among them, 10 polymorphic sites were selected for genotyping in our beef cattle. We performed SNP, haplotype and linkage disequilibrium studies on 419 Korean native cattle with the 10 SNPs in the FABP genes. Statistical analysis revealed that 220AG (I74V) and 348+303TC polymorphisms in FABP4 showed putative associations with BF traits (P=0.02 and 0.01, respectively). Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence BF in beef cattle.
authors.affiliation: Laboratory of Bioinformatics and Biostatistics, Interdisciplinary Program in Bioinformatics, Department of Statistics, Seoul National University, Seoul, Korea.
authors.forename: Seoae
authors.initials: S
authors.lastname: Cho
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
authors.forename: Du-Hak
authors.initials: DH
authors.lastname: Yoon
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Sohg
authors.initials: S
authors.lastname: Namgoong
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Han
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Kim
authors.forename: Il-Cheong
authors.initials: IC
authors.lastname: Cheong
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D001835:Body Weight / Q000235:genetics; D002417:Cattle; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D007723:Korea; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D050556:Fatty Acid-Binding Proteins