Matrix polymeric excipients: comparing a novel interpolyelectrolyte complex with hydroxypropylmethylcellulose.
The in vitro dissolution, swelling, and erosion behavior of monolithic matrix systems containing the well-known hydrophilic polymer, hydroxypropylmethylcellulose, and a combination of chitosan and polycarbophil in the form of an interpolyelectrolyte complex were compared in this study. The two different types of matrix systems showed both a combination of swelling and erosion as the drug release mechanism. Kinetic analysis of the in vitro release profiles of water-soluble drugs from the matrix tablets illustrated that those containing the chitosan-polycarbophil complex exhibited higher mean dissolution time values and therefore slower drug release compared with the other matrix systems. The analysis also indicated that zero-order release kinetics were approached for some of the formulations containing the chitosan-polycarbophil complex, while this could not be achieved for those containing hydroxypropylmethylcellulose.
Lu
Zhilei
Z
Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa.
Chen
Weiyang
W
Olivier
Eugene
E
Hamman
Josias H
JH
D000180:Acrylic Resins; D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D048271:Chitosan; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000032:analysis; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013607:Tablets
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005079:Excipients; D004364:Pharmaceutical Preparations; D011108:Polymers; D013607:Tablets; D065347:Hypromellose Derivatives; C030312:calcium polycarbophil; D008747:Methylcellulose; D048271:Chitosan