[Effects of Citrus aurantium extract on liver antioxidant defense function in experimental diabetic mouse].
OBJECTIVE
To study the effect of Citrus aurantium extract on liver antioxidant ability in experimental diabetic mice.


METHODS
Experimental diabetic mice were treated with C. aurantium extract (C. aurantium 5, 10, 15g/ kg) respectively. After 5 weeks, the general status, liver antioxidant ability and the change of livers histological were observed.


RESULTS
Experimental diabetic mice groups were treated with C. aurantium extract in comparison with the experimental diabetic mice group. It was indicated that the levels of blood glucose were significantly reduced (P < 0.05), the levels of glutathione (GSH) were remarkably increased (P < 0.05). The activities of glutathione peroxidase (GSHPx), the contents of malon dialdehyde (MDA) and nitric oxide (NO) were significantly reduced (P < 0.01). The activities of superoxide dismutase (SOD) were increased in liver. The liver histological damages of experimental diabetic mice treated with C. aurantium extract were abated in comparison with the experimental diabetic mice under light microscope observation.


CONCLUSIONS
It was suggested that the extract of C. aurantium could effectively enhance the liver antioxidant function and decrease hepatocyte damages.
Jiao
Shirong
S
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China. jsrong2004@163.com
Huang
Chengyu
C
Wang
Ho
H
Yu
Shuang
S
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002957:Citrus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase