title: Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum.
abstract: Usimines A-C ( 1- 3), three new usnic acid derivatives, have been isolated from a MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of 1- 3 were determined by analysis of their spectroscopic data (NMR, UV, MS) and by chemical methods. The known compound usnic acid ( 4) was also obtained. Compounds 1- 4 showed moderate inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B).
authors.affiliation: College of Medical and Life Sciences, Silla University, Busan 617-736, Korea.
authors.forename: Changon
authors.initials: C
authors.lastname: Seo
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Sohn
authors.forename: Seong Min
authors.initials: SM
authors.lastname: Park
authors.forename: Joung Han
authors.initials: JH
authors.lastname: Yim
authors.forename: Hong Kum
authors.initials: HK
authors.lastname: Lee
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
mesh_terms: D000864:Antarctic Regions; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*
chemical_list: D001572:Benzofurans; C529411:usimine A; C529412:usimine B; C529413:usimine C; C073339:usnic acid; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1