Cyclosporin effectively inhibits posterior capsule opacification after phacoemulsification in rabbits: a preliminary study.
OBJECTIVE
To evaluate whether cyclosporin A prevents or reduce posterior capsule opacification after phacoemulsification surgery in rabbit eyes.


METHODS
Twenty rabbits underwent cataract surgery in their right eyes were randomized into two groups. In group 1, 0.1 mL cyclosporin A (0.5 mg/mL) was given into the capsular bag after phacoemulsification and 0.1 mL cyclosporin A (0.5 mg/mL) was injected subconjunctivally once every 3 days for 1 week. Group 2 served as a control group. The development of posterior capsule opacification was assessed weekly, its density was graded clinically, and the proliferation of lens epithelial cells was evaluated histologically.


RESULTS
On clinical assessment, cyclosporin A was significantly effective in preventing posterior capsule opacification compared with controls (P = 0.0045). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment group, in contrast to multilayer lens epithelial cells proliferation in the control group.


CONCLUSIONS
The preliminary results indicate that cyclosporin A is effective in suppressing posterior capsule opacification in rabbits, yet requires further investigation.
Totan
Yüksel
Y
Department of Ophthalmology, Medical School, Fatih University, Ankara, Turkey.
Yağci
Ramazan
R
Erdurmuş
Mesut
M
Bayrak
Reyhan
R
Hepşen
Ibrahim Feyzi
IF
D000818:Animals; D002386:Cataract / Q000209:etiology / Q000517:prevention & control*; D002387:Cataract Extraction / Q000009:adverse effects* / Q000379:methods*; D049109:Cell Proliferation / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D004847:Epithelial Cells / Q000473:pathology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007903:Lens Capsule, Crystalline / Q000473:pathology; D018918:Phacoemulsification / Q000009:adverse effects*; D011184:Postoperative Period; D011817:Rabbits
D007166:Immunosuppressive Agents; D016572:Cyclosporine