Generalized granuloma annulare associated with gastrointestinal stromal tumour: case report and review of clinical features and management.
The paraneoplastic variant of granuloma annulare (GA) is a rare cutaneous manifestation of underlying malignancy that is most commonly associated with systemic lymphoma. We report an interesting case of a patient with gastrointestinal stromal tumour (GIST) of the stomach presenting with extensive generalized GA. GIST was diagnosed 2 months after the diagnosis of GA. Resolution of the GA was seen 1 month after surgical excision of GIST. The close correlation of the clinical courses of these two rare diseases suggests that their coexistence was more than a coincidental finding. This case highlights the importance of excluding paraneoplastic GA, especially in cases where the skin manifestations are extensive and resistant to treatment.
Chiu
M L S
ML
National Skin Centre, Singapore. monachiu_2000@yahoo.com.hk
Tang
M B Y
MB
D000328:Adult; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016460:Granuloma Annulare / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome