title: Similar mechanisms formed ring markers containing chromosome 12 pericentromeric region in two patients with therapy-related acute myeloid leukemia.
abstract: Two cases of therapy-related acute myeloid leukemia showed complex karyotypes, including a small ring and a larger D-chromosome. Multicolor fluorescence in situ hybridization and bacterial artificial chromosome and fosmid clones showed that both ring chromosomes were composed entirely of material excised from chromosome 12. The deleted segment of 12 was found fused to the short arm of a D-group chromosome. We hypothesized that similar mechanisms were involved in both rearrangements. A fusion at the short arms of chromosome 12 and a D-group chromosome was accompanied by excision and ligation of the chromosome 12 pericentromeric region to form a small ring chromosome.
authors.affiliation: Department of Genetics and Microbiology, University of Bari, Bari, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Impera
authors.forename: Francesco
authors.initials: F
authors.lastname: Albano
authors.forename: Marco
authors.initials: M
authors.lastname: Mancini
authors.forename: Ana
authors.initials: A
authors.lastname: Aventin
authors.forename: Mariano
authors.initials: M
authors.lastname: Rocchi
authors.forename: Clelia Tiziana
authors.initials: CT
authors.lastname: Storlazzi
mesh_terms: D022202:Chromosomes, Artificial, Bacterial; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D012303:Ring Chromosomes