title: Diagnosing and management of iatrogenic moderate and severe ovarian hyperstymulation syndrome (OHSS) in clinical material.
abstract: Severe ovarian hyperstymulation syndrome is a rare but potentially life-threatening complication in patients undergoing assisted reproductive techniques (ART). The pathogenesis of this condition is likely to be multifactorial. The aim of the retrospective study was to present management in moderate and severe iatrogenic ovarian hyperstymulation syndrome (OHSS) in clinical material. The study group was 19 women, admitted to the Department of Obstetrics and Gynecology in Central Clinical Hospital of Ministry of Interior and Administration in Warsaw from large outpatient infertility center "Novum" in Warsaw with moderate and severe OHSS between 14.07.2004 and 8.11.2005. Laboratory tests and ultrasound examination of the ovarian size and ascites were performed, abdominal circumference was measured. Patients were treated with rehydration with intravenous crystalloids and colloids, diuretics, antibiotics, anticoagulants and ultrasound-guided paracentesis if symptoms of ascites become severe (ascites causes pain and compromised pulmonary function). Oral intake of water was restricted, monitoring of fluid intake and output, and daily monitoring of body weight was performed. During treatment controlled laboratory tests were done. In one patient occurred intra-abdominal hemorrhage from ovarian rupture and laparotomy with oophorectomy was performed. The ovarian hyperstimulation syndrome is still a difficult diagnostic and therapeutic problem and more studies are required to elucidate pathophysiology of OHSS. Because of still unknown etiology treatment is empirical and in most of cases bases on experience of medical team. Thus, the management in individual patients varies according to the severity of ovarian hyperstymulation syndrome and its complications.
authors.affiliation: Department of Obstetrics and Gynecology in Central Clinical Hospital of Ministry of Interior and Administration, Warsaw, Poland. jakimiuk@yahoo.com
authors.forename: Artur J
authors.initials: AJ
authors.lastname: Jakimiuk
authors.forename: Anna
authors.initials: A
authors.lastname: Fritz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Grzybowski
authors.forename: Irena
authors.initials: I
authors.lastname: Walecka
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewandowski
mesh_terms: D000328:Adult; D000418:Albumins / Q000008:administration & dosage / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects; D001835:Body Weight; D003102:Colloids / Q000008:administration & dosage / Q000009:adverse effects; D000077324:Crystalloid Solutions; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000009:adverse effects; D007049:Iatrogenic Disease; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000009:adverse effects; D009929:Organ Size; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010053:Ovary / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014463:Ultrasonography
chemical_list: D000418:Albumins; D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D003102:Colloids; D000077324:Crystalloid Solutions; D004232:Diuretics; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions