title: Avian influenza virus, a very sticky situation.
abstract: The appearance of the highly pathogenic avian influenza virus H5N1 highlighted the potential impact of influenza virus on humanity. The emergence of this high profile virus stimulated much research towards a better understanding of the key determinants for successful human-to-human transmission and as such has provided new directions for therapeutic intervention strategies. For example, a phylogenetic-based grouping of influenza virus sialidases into either Group 1 or 2 has been proposed. This has provided new opportunity for the development of Group 1-specific anti-influenza drugs. Furthermore, a number of next generation sialidase inhibitors as anti-influenza drugs have also been developed.
authors.affiliation: Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia. m.vonitzstein@griffith.edu.au
authors.forename: Mark
authors.initials: M
authors.lastname: von Itzstein
mesh_terms: D000818:Animals; D001717:Birds / Q000821:virology*; D050260:Carbohydrate Metabolism; D015195:Drug Design; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D011200:Poultry / Q000821:virology
chemical_list: D009439:Neuraminidase