title: Mechanisms and functional implications of adult neurogenesis.
abstract: The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factors that regulate proliferation and fate determination of adult neural stem cells and describe recent studies concerning the integration of newborn neurons into the existing neural circuitry. We further address the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
authors.affiliation: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000502:physiology; D002454:Cell Differentiation; D006801:Humans; D009422:Nervous System Diseases / Q000473:pathology; D009474:Neurons / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology*