Synthesis and biological evaluation of diversely substituted indolin-2-ones.
The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptomyces chartreusis, a Gram-negative bacterium Escherichia coli and a yeast Candida albicans.
Bouchikhi
Fadoua
F
Laboratoire SEESIB, Université Blaise Pascal, UMR 6504 du CNRS, 24 avenue des Landais, F-63177 Aubière Cedex, France.
Rossignol
Emilie
E
Sancelme
Martine
M
Aboab
Bettina
B
Anizon
Fabrice
F
Fabbro
Doriano
D
Prudhomme
Michelle
M
Moreau
Pascale
P
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001686:Biological Phenomena / Q000187:drug effects*; D003198:Computer Simulation; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D050296:Microbial Viability / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007211:Indoles; D047428:Protein Kinase Inhibitors; C456900:indolin-2-one