Cytokines in combination to treat radiation-induced myelosuppresssion: evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys.
Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to granulopoiesis. Early administration of Erythropoietin did not prevent radiation-induced anemia.
Drouet
Michel
M
Delaunay
Christophe
C
Grenier
Nancy
N
Garrigou
Philippe
P
Mayol
Jean-François
JF
Hérodin
Francis
F
D000818:Animals; D001803:Blood Transfusion; D016207:Cytokines / Q000008:administration & dosage / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004630:Emergencies; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D007377:Interleukin-3 / Q000008:administration & dosage / Q000627:therapeutic use; D008252:Macaca fascicularis; D008565:Membrane Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D010198:Pancytopenia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D011092:Polyethylene Glycols; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D019089:Stem Cell Factor / Q000008:administration & dosage / Q000627:therapeutic use; D013926:Thrombopoietin / Q000008:administration & dosage / Q000627:therapeutic use
D016207:Cytokines; D007377:Interleukin-3; D008565:Membrane Proteins; D011994:Recombinant Proteins; D019089:Stem Cell Factor; C084881:flt3 ligand protein; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D013926:Thrombopoietin; D000069585:Filgrastim