[Coincidence of Graves' disease and Angelman syndrome in a 13 month old boy].
Both in Angelman-Syndrome and Graves' disease somatic and psychomotoric retardation, agitation and sleep disorder are major symptoms and signs. We report on the coincidence of both diseases in a 13 month old boy. Due to the overlapping pathology physicians should take special care on symptoms and signs of thyroid dysfunction in children with Angelman-Syndrome. In the case of coincidence a delayed diagnosis and treatment of hyperthyroidism could be avoided.
Karremann
M
M
Universitätsklinik und Poliklinik für Kinder- und Jugendmedizin der Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany. michael.karremann@medizin.uni-halle.de
Cseke-Friedrich
A
A
Horneff
G
G
D000367:Age Factors; D017204:Angelman Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015897:Comorbidity; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008297:Male; D008713:Methimazole / Q000008:administration & dosage / Q000627:therapeutic use; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use
D000927:Anticonvulsants; D013956:Antithyroid Agents; D008713:Methimazole; D014635:Valproic Acid; D013974:Thyroxine