title: Microwave promoted one-pot synthesis of novel A-ring fused steroidal dehydropiperazines.
abstract: The preparation of ring-A fused steroidal dehydropiperazine at the 3,4-position is herein described. The novel steroidal dehydropiperazines were prepared from the annulation reaction of ethylenediamine with 3-keto-4-en steroids in a one-pot reaction under microwave irradiation. The key step involves base catalysed aerial oxidation of the C-6 methylene group followed by cyclocondensation of ethylenediamine via Michael addition reaction.
authors.affiliation: Medicinal Chemistry Division, North-East Institute of Science and Technology, Jorhat-785006, India.
authors.forename: Moyurima
authors.initials: M
authors.lastname: Borthakur
authors.forename: Madan G
authors.initials: MG
authors.lastname: Barthakur
authors.forename: Romesh C
authors.initials: RC
authors.lastname: Boruah
mesh_terms: D002384:Catalysis; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005029:Ethylenediamines; D010879:Piperazines; D013256:Steroids; C031234:ethylenediamine