Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Congenital adrenal hyperplasia due to steroid 11beta-hydroxylase deficiency is a genetic disorder of steroidogenesis, transmitted as an autosomal recessive trait. It is associated with low renin hypertension, hypokalemia, hyperandrogenemia and genital ambiguity in affected females. Mutations in the CYP11B1 gene, causing 11beta-hydroxylase deficiency in the zona fasciculata in the adrenal cortex, have been identified. The indicators of congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency, include increased serum concentrations of desoxycorticosterone, 11 deoxycortisol and delta4-androstenedione, and suppressed plasma renin concentrations. The disorder is treated by administration of glucocorticoids.
Nimkarn
Saroj
S
Adrenal Steroid Disorders Program, Mount Sinai School of Medicine, New York, New York 10029, USA.
New
Maria I
MI
D000302:Adrenal Cortex / Q000378:metabolism; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000209:etiology; D009154:Mutation; D013252:Steroid 11-beta-Hydroxylase / Q000235:genetics / Q000378:metabolism*
D005938:Glucocorticoids; D013252:Steroid 11-beta-Hydroxylase