title: Zarit burden inventory and activities of daily living in the behavioral variant of frontotemporal dementia.
abstract: BACKGROUND
  Activities of daily living (ADL) and caregiver burden are known to have a major impact on the decision to institutionalize patients with Alzheimer's disease (AD), yet little research has been done on these aspects in patients with frontotemporal dementia (FTD).
  
  
  OBJECTIVE
  To compare ADL and caregiver burden in FTD and in early-onset AD.
  
  
  METHODS
  We compared 26 FTD and 28 AD patients with respect to the Neuropsychiatric Inventory (NPI), Mini Mental State Examination, Mattis Dementia Rating Scale (MDRS), Disability Assessment for Dementia (DAD) and Zarit Burden Inventory (ZBI).
  
  
  RESULTS
  Demographic variables for FTD and AD were similar. FTD patients obtained a significantly higher NPI behavioral score than AD patients (median, 39.5 vs. 11; p < 0.0001). However, the two groups did not differ in their total DAD score. No correlations were observed between DAD and cognitive status (MDRS) or between DAD and behavioral impairment (NPI). The ZBI was higher in FTD than in AD patients (median, 40 vs. 18.5; p = 0.0004) and was correlated with the NPI in both groups.
  
  
  CONCLUSIONS
  Functional disability was similar in FTD and AD patients. Nevertheless, the caregiver burden was higher in FTD than in AD, a result that has important implications for caregiver help.
authors.affiliation: Memory Clinic, Department of Neurology, University Hospital, Nantes, France. claire.boutoleau-bretonniere@chu-nantes.fr
authors.forename: Claire
authors.initials: C
authors.lastname: Boutoleau-Bretonnière
authors.forename: Martine
authors.initials: M
authors.lastname: Vercelletto
authors.forename: Christelle
authors.initials: C
authors.lastname: Volteau
authors.forename: Pierre
authors.initials: P
authors.lastname: Renou
authors.forename: Estelle
authors.initials: E
authors.lastname: Lamy
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017028:Caregivers / Q000523:psychology / Q000706:statistics & numerical data; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007326:Institutionalization / Q000706:statistics & numerical data; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011595:Psychomotor Agitation / Q000453:epidemiology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires