Aldosterone-induced signalling and cation transport in the distal nephron.
Aldosterone is an important regulator of Na(+) and K(+) transport in the distal nephron modulating the surface expression of transporters through the action of the mineralocorticoid receptor as a ligand-dependent transcription factor. Aldosterone stimulates the rapid activation of protein kinase-based signalling cascades that modulate the genomic effects of the hormone. Evidence is accumulating about the multi-factorial regulation of the epithelial sodium channel (ENaC) by aldosterone. Recent published data suggests that the activation of a novel PKC/PKD signalling pathway through the c-Src-dependent trans-activation of epidermal growth factor receptor contributes to early ENaC trafficking in response to aldosterone.
Thomas
Warren
W
Department of Molecular Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ie
McEneaney
Victoria
V
Harvey
Brian J
BJ
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002412:Cations; D002450:Cell Communication; D004789:Enzyme Activation; D004815:Epidermal Growth Factor / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D008954:Models, Biological; D009399:Nephrons / Q000378:metabolism*; D011188:Potassium / Q000737:chemistry; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D015533:Transcriptional Activation
D002412:Cations; D000450:Aldosterone; D004815:Epidermal Growth Factor; D011494:Protein Kinases; D011188:Potassium