title: Review of linear epidermal nevus with oral mucosal involvement--series of five new cases.
abstract: BACKGROUND
  Linear epidermal nevi are sporadic hamartomatous alterations of the epidermis and superficial dermis that clinically appear as verrucous papules and plaques distributed in a linear pattern following Blaschko's lines. Their extent varies from unilateral involvement (nevus unius lateris) to extensive bilateral involvement (ichthyosis hystrix). Oral mucosal lesions have rarely been described.
  
  
  OBJECTIVE
  We review the literature, focusing on the rare intraoral manifestations of linear epidermal nevus.
  
  
  METHODS
  We present a series of five new cases with oral mucosal involvement. Four cases had associated cutaneous lesions and one case had oral lesions exclusively. Histopathologic evaluation of lesional tissue in four cases showed hyperkeratosis, acanthosis, epithelial hyperplasia, and papillomatosis. Dental abnormalities, consisting of enamel hypoplasia and congenitally missing teeth, were noted in one patient adjacent to the oral lesions.
authors.affiliation: Oral and Maxillofacial Pathology, The Ohio State University, 305 W12th Avenue, Columbus, OH 43210, USA. allen.12@osu.edu
authors.forename: C
authors.initials: C
authors.lastname: Haberland-Carrodeguas
authors.forename: C M
authors.initials: CM
authors.lastname: Allen
authors.forename: J G L
authors.initials: JG
authors.lastname: Lovas
authors.forename: J
authors.initials: J
authors.lastname: Hicks
authors.forename: C M
authors.initials: CM
authors.lastname: Flaitz
authors.forename: R
authors.initials: R
authors.lastname: Carlos
authors.forename: S
authors.initials: S
authors.lastname: Stal
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005148:Facial Dermatoses / Q000150:complications* / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009506:Nevus / Q000150:complications* / Q000473:pathology