title: Interactive web simulation for propofol and fospropofol, a new propofol prodrug.
abstract: Using pharmacokinetic and pharmacodynamic data published in the scientific literature, we have developed interactive on-line simulations to model administration of propofol and fospropofol, a new water-soluble prodrug formulation of propofol. The prodrug formulation of fospropofol leads to a delayed onset to peak concentrations of propofol. A comparison simulation that overlays administration of fospropofol and propofol allows clinicians to understand the differences of administering fospropofol and traditional propofol. The simulations have the added advantage of allowing for differences among patients documented in test studies and the use of different models.
authors.affiliation: Department of Anesthesiology, University of Florida College of Medicine, PO Box 100254, Gainesville, FL 32610-0254, USA. syavas@anest.ufl.edu
authors.forename: Sinan
authors.initials: S
authors.lastname: Yavas
authors.forename: David
authors.initials: D
authors.lastname: Lizdas
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Gravenstein
authors.forename: Samsun
authors.initials: S
authors.lastname: Lampotang
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003198:Computer Simulation; D003243:Consciousness / Q000187:drug effects; D004334:Drug Administration Schedule; D054796:Drug Dosage Calculations; D006801:Humans; D007263:Infusions, Parenteral; D020407:Internet; D008297:Male; D008954:Models, Biological; D010597:Pharmacogenetics; D011355:Prodrugs / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015742:Propofol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015203:Reproducibility of Results
chemical_list: D018686:Anesthetics, Intravenous; D011355:Prodrugs; C472965:fospropofol; D015742:Propofol