[Effect of different light regimens on the development of metabolic syndrome of aging rats].
During two years the influence of light regimens (standard lightning--LD, constant lightning--LL, natural lightning of the North-West of Russia--NL) and of melatonin on the development of metabolic syndrome of ageing LIO rats was studied. It was found out that during the process of ageing of rats kept in the conditions of the broken rhythm of day and night, different breaches of metabolism in the form of abdominal obesity, hyperinsulinemia, hypercholesterolemia, hyperglycemia, hyperbetalipoproteinemia and glycosuria occurred. These breaches can be considered to be metabolic syndrome or the syndrome of insulinoresistancy. The use of melatonin at night time starting from the rats' age of four months slowed down the age breaches of metabolism in rats. This fact proves indirectly the lack of this hormone in the conditions of natural lightning of the North-West of Russia.
Vinogradova
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D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004435:Eating; D007333:Insulin Resistance; D008027:Light; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D010455:Peptides / Q000097:blood; D051381:Rats; D012621:Seasons
D000975:Antioxidants; D001786:Blood Glucose; D008074:Lipoproteins; D010455:Peptides; C050632:polypeptide C; D002784:Cholesterol; D008550:Melatonin