title: Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period.
abstract: Bipolar disorders are usually defined by alternative mood states, but a more precise characterization of the euthymic period could provide further insights into the pathophysiology of bipolar disorders. Surprisingly, few studies have investigated core affective dimensions in euthymic bipolar patients. In this study, we assessed 179 euthymic bipolar patients (score<12 on the Montgomery-Asberg Depression Scale and a score<6 on the Bech-Rafaelsen Mania Scale) compared with 86 control subjects using French versions of the Affective Lability Scale (ALS) and the Affect Intensity Measure (AIM). Data were analyzed by logistic regression. Our results showed that euthymic bipolar subjects reported having more intense emotions than controls and also had a higher affective lability. High scores in both affective dimensions were associated with a significantly higher risk for psychiatric axis I comorbidity. Moreover, a high affective lability score was associated with an earlier age of onset for bipolar disease. Affective lability and affect intensity might be two core dimensions of bipolar disorder during euthymic periods, suggesting that bipolar disorder is not circumscribed to mood episodes but also affects emotional reactivity between episodes. Both dimensions could account for the stress reactivity of bipolar patients that may lead to relapses.
authors.affiliation: Département de Psychiatrie adulte, Bâtiment Lescure, CHS Charles Perrens, 121 rue de la Béchade, 33076 Bordeaux Cedex, France. chenry@ch-perrens.fr
authors.forename: Chantal
authors.initials: C
authors.lastname: Henry
authors.forename: Donatienne
authors.initials: D
authors.lastname: Van den Bulke
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Roy
authors.forename: Joël
authors.initials: J
authors.lastname: Swendsen
authors.forename: Katia
authors.initials: K
authors.lastname: M'Baïlara
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Siever
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D017668:Age of Onset; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology; D001143:Arousal / Q000235:genetics / Q000502:physiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D015897:Comorbidity; D035061:Control Groups; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007206:Individuality; D016015:Logistic Models; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology; D010555:Personality Inventory / Q000706:statistics & numerical data; D010641:Phenotype; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012307:Risk Factors; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000523:psychology; D013694:Temperament