Transient acquired hemophilia associated with Mycoplasma pneumoniae pneumonia.
Acquired hemophilia is a rare disorder caused by autoantibodies to factor VIII (FVIII) (also referred to as factor VIII inhibitors or anti-FVIII) and may be associated with pregnancy, underlying malignancy, or autoimmune disorders. A 33-month-old girl who presented with hematochezia and ecchymotic skin lesions was diagnosed with Mycoplasma pneumoniae pneumonia by serology and polymerase chain reaction. Hematologic studies showed a prolonged activated partial thromboplastin time (aPTT), partially corrected mixing test for aPTT, reduced levels of FVIII, and the presence of antibodies against FVIII. She was treated conservatively with prednisone and intravenous immunoglobulin (IVIG) without FVIII transfusion and recovered without sequelae. This report provides the first description of acquired hemophilia due to anti-FVIII in association with M. pneumoniae in Korea. We discuss this case in the context of the current literature on acquired hemophilia in children.
Kim
Min Sun
MS
Department of Pediatrics and the Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, Korea.
Kilgore
Paul E
PE
Kang
Ju Sung
JS
Kim
Sun Young
SY
Lee
Dae Yeol
DY
Kim
Jung Soo
JS
Hwang
Pyoung Han
PH
D001323:Autoantibodies / Q000097:blood; D002675:Child, Preschool; D005169:Factor VIII / Q000276:immunology; D005260:Female; D006467:Hemophilia A / Q000209:etiology*; D006801:Humans; D010314:Partial Thromboplastin Time; D011019:Pneumonia, Mycoplasma / Q000150:complications* / Q000276:immunology; D013997:Time Factors
D001323:Autoantibodies; D005169:Factor VIII