[Pigment epithelium-derived factor and its application in retinal angiogenic diseases].
Retinal neovascularization (RNV) is one of the most important causes of blindness. No efficient treatment for RNV is available. Pigment epithelium-derived factor (PEDF) is a natural inhibitor of angiogenesis. It plays an important role in the modulation of ocular neovascularization. It has been demonstrated recently that the ischemia-induced retinal neovascularization can be dramatically inhibited by the recombinant PEDF protein or local viral vector-mediated delivery of PEDF cDNA, which predicts PEDF to be an optional strategy for intractable retinal angiogenic diseases like diabetic retinopathy, retinopathy of prematurity, and central retinal vein occlusion. Therefore, it is necessary to review the biological aspects of PEDF, its effect on the inhibition of angiogenesis and the prospect of using PEDF for the treatment of retinal neovascularization.
Liu
Hui
H
Department of Ophthalmology, Second Hospital of Jilin University, Changchun 130041, China.
Su
Guan-fang
GF
D005136:Eye Proteins / Q000627:therapeutic use; D006801:Humans; D009389:Neovascularization, Pathologic / Q000628:therapy; D009414:Nerve Growth Factors / Q000627:therapeutic use; D015861:Retinal Neovascularization / Q000628:therapy*; D015843:Serpins / Q000627:therapeutic use; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor