title: Anaemia in acute HIV-1 subtype C infection.
abstract: BACKGROUND
  The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection.
  
  
  METHODS
  HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and at regular intervals in the first twelve months of HIV infection.
  
  
  RESULTS
  Fifty-seven participants with acute HIV infection were identified at a median of 14.5 days post-infection (range 10-81) and were enrolled in the CAPRISA Acute Infection cohort at a median of 41 days post-infection (range 15-104). Mean haemoglobin prior to HIV-1 infection was 12.7 g/dL, with a mean decline of 0.46 g/dL following infection. The prevalence of anaemia increased from 25.0% prior to HIV-1 infection to 52.6% at 3 months post-infection, 61.1% at 6 months post-infection, and 51.4% at 12 months post-infection.
  
  
  CONCLUSIONS
  Haematologic derangements and anaemia with a trend towards iron deficiency are common with acute HIV-1 subtype C infection in this small cohort. The negative impact of anaemia concurrent with established HIV infection upon morbidity and mortality has been well documented but the prognostic potential and long-term effects of anaemia during acute HIV-1 infection remain unknown.
authors.affiliation: Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Koleka
authors.initials: K
authors.lastname: Mlisana
authors.forename: Sara C
authors.initials: SC
authors.lastname: Auld
authors.forename: Anneke
authors.initials: A
authors.lastname: Grobler
authors.forename: Francois
authors.initials: F
authors.lastname: van Loggerenberg
authors.forename: Carolyn
authors.initials: C
authors.lastname: Williamson
authors.forename: Itua
authors.initials: I
authors.lastname: Iriogbe
authors.forename: Magdalena E
authors.initials: ME
authors.lastname: Sobieszczyk
authors.forename: Salim S
authors.initials: SS
authors.lastname: Abdool Karim
mesh_terms: D000208:Acute Disease; D000740:Anemia / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006679:HIV Seropositivity / Q000097:blood; D015497:HIV-1; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D013019:South Africa; D013997:Time Factors
chemical_list: D006454:Hemoglobins