[In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions].
ABCG2, a transporter of the ATP-binding cassette family, is known to play a prominent role in the absorption, distribution, metabolism, and excretion of xenobiotics. Drug-transporter interactions are commonly screened by in vitro systems using transfected insect and/or human cell lines.
Pál
Akos
A
SOLVO Biotechnológiai Zrt., Szeged.
Kis
Emese
E
Méhn
Dóra
D
Glavinas
Hristos
H
Nagy
Tünde
T
Mészaros
Péter
P
Báthori
György
G
Krajcsi
Péter
P
Falkay
György
G
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D004347:Drug Interactions; D004358:Drug Therapy; D006801:Humans; D007313:Insecta; D009363:Neoplasm Proteins / Q000187:drug effects / Q000378:metabolism*; D015262:Xenobiotics / Q000493:pharmacokinetics
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins; D015262:Xenobiotics