title: Microtubule dynamics regulated by stathmin.
abstract: Microtubules perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin-tubulin interaction gradients. Computer simulation of the model with stathmin-tubulin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin-tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored.
authors.affiliation: Computational Neuroscience and Neuroimaging Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India.
authors.forename: Kh
authors.initials: Kh
authors.lastname: Budhachandra
authors.forename: R K
authors.initials: RK
authors.lastname: Brojen Singh
authors.forename: G I
authors.initials: GI
authors.lastname: Menon
mesh_terms: D003198:Computer Simulation; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure*; D008954:Models, Biological; D050777:Stathmin / Q000378:metabolism*
chemical_list: D050777:Stathmin