Ghrelin gets its GOAT.
Ghrelin, a powerful appetite-stimulating hormone secreted by the stomach, is modified by an octanyl side chain on its third amino acid, a serine, which is essential for its activity. A recent study (Yang et al., 2008) reports identification of the enzyme catalyzing the addition of this octanyl, GOAT.
Gardiner
James
J
Department of Investigative Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Bloom
Steve
S
D000217:Acyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects; D002460:Cell Line; D003001:Cloning, Molecular; D004791:Enzyme Inhibitors / Q000494:pharmacology; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D054440:Receptors, Ghrelin / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D012694:Serine / Q000378:metabolism
D004791:Enzyme Inhibitors; D054439:Ghrelin; D008565:Membrane Proteins; D054440:Receptors, Ghrelin; D011994:Recombinant Proteins; C422650:ghrelin, des-n-octanoyl; D012694:Serine; D000217:Acyltransferases; C526983:Mboat4 protein, mouse