title: Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins.
abstract: We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Athanasiadou
authors.forename: Kostas
authors.initials: K
authors.lastname: Stamatopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Gaitatzi
authors.forename: Niki
authors.initials: N
authors.lastname: Stavroyianni
authors.forename: Athanasios
authors.initials: A
authors.lastname: Fassas
authors.forename: Achilles
authors.initials: A
authors.lastname: Anagnostopoulos
mesh_terms: D002869:Chromosome Aberrations; D022801:Complementarity Determining Regions / Q000235:genetics*; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics*; D007134:Immunoglobulin Switch Region; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics*; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*
chemical_list: D022801:Complementarity Determining Regions; D007074:Immunoglobulin G; D009363:Neoplasm Proteins; D011947:Receptors, Antigen, B-Cell