Intron mis-splicing: no alternative?
A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.
Roy
Scott William
SW
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA. scottwroy@gmail.com
Irimia
Manuel
M
D017398:Alternative Splicing; D000818:Animals; D016678:Genome; D006801:Humans; D007438:Introns / Q000235:genetics*; D020871:RNA Stability; D017381:Spliceosomes; D014158:Transcription, Genetic