Characterization of two novel HLA class I alleles: HLA-A*310103 and HLA-B*9531.
Two novel human leucocyte antigen (HLA) class I alleles were characterized by means of sequencing-based typing techniques. HLA-A*310103 was identified in a cord blood unit from a Caucasoid individual. The sequence of this allele is identical to that of HLA-A*310102 except for a silent mutation in exon 3 at position 480 (G --> A). HLA-B*9531 was found in a Caucasoid female patient registered on the heart transplantation waiting list in the North Italy Transplant programme. This new variant differs from HLA-B*1503 at position 572 (G --> C) in exon 3. This nucleotide change leads to an amino acidic substitution at codon 167 from tryptophan to serine.
Frison
S
S
Regenerative Medicine Department, Organ and Tissue Transplantation Immunology, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Longhi
E
E
Andreini
E
E
Poli
F
F
Scalamogna
M
M
D000483:Alleles; D001483:Base Sequence; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D015234:HLA-A Antigens; D015235:HLA-B Antigens