title: Open-source platform for the analysis of liquid chromatography-mass spectrometry (LC-MS) data.
abstract: The analysis of protein mixtures by liquid chromatography-mass spectrometry (LCMS) requires tools for viewing and navigating LC-MS data, locating peptides in LC-MS data, and eliminating low-quality peptides. msInspect, an open source platform, can carry out these steps for single experiments and can align and normalize peptide features in comparative studies with multiple LC-MS runs. In addition, msInspect can analyze quantitative studies with and without isotopic labels to generate peptide arrays.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Fitzgibbon
authors.forename: Wendy
authors.initials: W
authors.lastname: Law
authors.forename: Damon
authors.initials: D
authors.lastname: May
authors.forename: Andrea
authors.initials: A
authors.lastname: Detter
authors.forename: Martin
authors.initials: M
authors.lastname: McIntosh
mesh_terms: D000465:Algorithms; D002853:Chromatography, Liquid / Q000706:statistics & numerical data*; D003627:Data Interpretation, Statistical; D006801:Humans; D013058:Mass Spectrometry / Q000706:statistics & numerical data*; D010455:Peptides / Q000032:analysis; D040081:Protein Array Analysis / Q000706:statistics & numerical data; D020543:Proteome / Q000032:analysis; D040901:Proteomics / Q000706:statistics & numerical data*; D012984:Software
chemical_list: D010455:Peptides; D020543:Proteome