title: 14-3-3 proteins in Echinococcus: their role and potential as protective antigens.
abstract: 14-3-3 Proteins are a family of highly conserved proteins among all eukaryotic organisms studied so far. As basically intracellular proteins, they play a key role in basic cellular events related to cellular proliferation, including signal transduction, cell-cycle control, cell differentiation and cell survival. The 14-3-3 proteins have been described and characterized in several parasites, and mostly studied in Echinococcus granulosus and Echinococcus multilocularis. Here, we review the discoveries regarding this protein family in the genus Echinococcus, describing new data about specific aspects related with their implication in the parasite biology and immunology in the frame of the host-parasite relationship.
authors.affiliation: Unidad de Patología Animal, Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA), Consejo Superior de Investigaciones Científicas (CSIC), Cordel de Merinas 40-52, 37008 Salamanca, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Siles-Lucas
authors.affiliation: Department of Parasitology, University of Hohenheim, Stuttgart, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Merli
authors.affiliation: Institute of Parasitology, University of Berne, Länggass Strasse 122, CH-3001 Berne, Switzerland.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gottstein
mesh_terms: D048948:14-3-3 Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000276:immunology; D000947:Antigens, Helminth / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D004443:Echinococcosis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D004446:Echinococcus / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D010802:Phylogeny; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D014612:Vaccines / Q000737:chemistry / Q000235:genetics / Q000276:immunology
chemical_list: D048948:14-3-3 Proteins; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015801:Helminth Proteins; D020033:Protein Isoforms; D014612:Vaccines