title: Biomimetic hydroxyapatite particulate nanofiber modified silicon: in vitro bioactivity.
abstract: A novel particulate nanofibrous hydroxyapatite (HA), which mimics the bone matrix, is presented as a surface functional material to modify silicon wafers by the electrospinning method. The HA precursors were treated with viscous polymer solution, and then electrospun under controlled conditions. After successive calcinations, the powder X-ray diffraction patterns of the samples revealed reflection toward the (300) HA plane that is linear with temperature. This prominent reflection suggests the crystallographic purity of the HA. Biocompatibility, cell proliferation, and microstructure were examined using AFM and FE-SEM. Morphology showed cell spreading and penetration instead of cell aggregation. The surface roughness as well as adhesion force was calculated using contact mode AFM. The results show that the composite matrix holds promise for use as a bone implant material.
authors.affiliation: Center for Healthcare Technology Development, Chonbuk National University, Jeonju, Republic of Korea.
authors.forename: Santosh
authors.initials: S
authors.lastname: Aryal
authors.forename: Madhab Prasad
authors.initials: MP
authors.lastname: Bajgai
authors.forename: Myung Seob
authors.initials: MS
authors.lastname: Khil
authors.forename: Hyung-Sub
authors.initials: HS
authors.lastname: Kang
authors.forename: Hak Yong
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000378:metabolism; D001826:Body Fluids / Q000737:chemistry; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D017886:Durapatite / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D053761:Nanocomposites / Q000737:chemistry*; D010006:Osteoblasts / Q000502:physiology / Q000648:ultrastructure; D012825:Silicon / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D020099:Coated Materials, Biocompatible; D017886:Durapatite; D012825:Silicon