title: Larvicidal effects of fungal Meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and Yellow fever.
abstract: The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1-7, previously obtained fungal secondary metabolites from Penicillium sp., against the third-instar larvae of A. aegypti. The lethal concentrations (LC(50) and LC(90)) of 1-7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC(50) value of 2.9 ppm, making it an attractive natural insecticide.
authors.affiliation: Instituto de Química, Universidade Federal da Bahia, Rua Barão de Geremoabo s/n, Ondina, Salvador - BA, 41950-350, Brasil. rmgeris@ufba.br
authors.forename: Regina
authors.initials: R
authors.lastname: Geris
authors.forename: Edson
authors.initials: E
authors.lastname: Rodrigues-Fo
authors.forename: Heloísa Helena
authors.initials: HH
authors.lastname: Garcia da Silva
authors.forename: Ionizete
authors.initials: I
authors.lastname: Garcia da Silva
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D003715:Dengue / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D008968:Molecular Conformation; D009032:Mosquito Control / Q000379:methods*; D010407:Penicillium / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015004:Yellow Fever / Q000517:prevention & control*
chemical_list: D007306:Insecticides; D013729:Terpenes