title: Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.
abstract: We investigated the relationship between the two main molecular markers for chloroquine resistance (Pfcrt T76 and Pfmdr-1 Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of Pfcrt T76, Pfmdr-1 Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment.
authors.affiliation: Institut de Recherche en Sciences de la Santé (IRSS), Bobo Dioulasso, Burkina Faso, and Centre Muraz, Bobo Dioulasso, Burkina Faso. tintohalidou@yahoo.fr
authors.forename: Halidou
authors.initials: H
authors.lastname: Tinto
authors.forename: Lougué
authors.initials: L
authors.lastname: Guekoun
authors.forename: Issaka
authors.initials: I
authors.lastname: Zongo
authors.forename: Robert Tinga
authors.initials: RT
authors.lastname: Guiguemdé
authors.forename: Umberto
authors.initials: U
authors.lastname: D'Alessandro
authors.forename: Jean Bosco
authors.initials: JB
authors.lastname: Ouédraogo
mesh_terms: D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D002050:Burkina Faso / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology; D026901:Membrane Transport Proteins / Q000235:genetics*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D009154:Mutation; D010963:Plasmodium falciparum / Q000187:drug effects*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000655:Amodiaquine; D000962:Antimalarials; D002738:Chloroquine; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D015800:Protozoan Proteins; C513498:Mdr1 protein, Plasmodium falciparum; C416369:PfCRT protein, Plasmodium falciparum