The invention and development of enflurane, isoflurane, sevoflurane, and desflurane.
Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics.
Terrell
Ross C
RC
Minrad, Inc., Orchard Park, New York 14127-1421, USA. mariposa4@yahoo.com
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends; D000077335:Desflurane; D015195:Drug Design; D004737:Enflurane / Q000138:chemical synthesis*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D008738:Methyl Ethers / Q000138:chemical synthesis*; D000077149:Sevoflurane
D006845:Hydrocarbons, Fluorinated; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D000077335:Desflurane; D007530:Isoflurane