The behavior of different carrageenans in pelletization by extrusion/spheronization.
kappa-Carrageenan is known as a novel pelletization aid in manufacturing of pellets by extrusion/spheronization. The implentation of kappa-carrageenan as a pelletization aid can overcome several disadvantages of commonly used microcrystalline cellulose (MCC) such as lacking disintegration and adsorption of several actives. The aim of this study was to compare different types of carrageenans from different suppliers: one iota-, five kappa-, and one lambda-carrageenan. The kappa-carrageenans had the best pelletization behavior. Four of the five tested kappa-carrageenans resulted in pellets with acceptable shapes, sizes, and size distributions using a high drug load of 80% hydrochlorothiazide. These pellets have similar properties over a wide range of water contents ranging from 90 to 105%. The filler, dicalcium phosphate, affected the pelletization process and the pellet properties of all investigated kappa-carrageenans.
Thommes
Markus
M
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany. markus.thommes@uni-duesseldorf.de
Kleinebudde
Peter
P
D002240:Carbohydrate Sequence; D002351:Carrageenan / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D007091:Image Processing, Computer-Assisted; D008969:Molecular Sequence Data; D010316:Particle Size; D011208:Powders; D013718:Tensile Strength; D014867:Water / Q000032:analysis
D005079:Excipients; D011208:Powders; D014867:Water; D002351:Carrageenan