Short synthesis of the C1-C14 stretch of discodermolide from building blocks prepared by asymmetric catalysis.
A convergent and stereoselective synthesis of the C1-C14 stretch of (+)-discodermolide demonstrates the utility of the "asymmetric catalysis approach" to complex polypropionates. The preparation of this complex synthon requires 15 steps in the longest linear sequence and 19 steps total from inexpensive materials.
Cao
Huanyan
H
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.
Parker
Kathlyn A
KA
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000473:Alkanes; D002219:Carbamates; D007783:Lactones; D011753:Pyrones; C071229:discodermolide