Structure-function relationship research of glycerol backbone-based cationic lipids for gene delivery.
Transfection activities of two series of synthetic glycerol backbone-based cationic lipids were studied as gene delivery carriers. The variable length of hydrocarbon chains, diverse quaternary ammonium heads, different linkage, as well as alternative anion combined with them allowed to find how these factors affect cationic lipids on their gene delivery performance. The structure-function relationship of the synthetic glycerol backbone-based cationic lipids was discussed, and the transfection efficiency of some of the cationic liposomes was superior or parallel to that of two commercial transfection agents.
Liu
Dongliang
D
Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, North Renmin RD. 2999th, Shanghai 201620, PR China. dut_liud@yahoo.com.cn
Qiao
Weihong
W
Li
Zongshi
Z
Chen
Yanxiang
Y
Cui
Xiuyun
X
Li
Kun
K
Yu
Lihua
L
Yan
Kelu
K
Zhu
Limin
L
Guo
Yuliang
Y
Cheng
Lvbo
L
D000818:Animals; D002219:Carbamates / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival; D004247:DNA / Q000378:metabolism; D004987:Ethers / Q000737:chemistry; D018014:Gene Transfer Techniques; D005990:Glycerol / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014162:Transfection / Q000379:methods
D002219:Carbamates; D002412:Cations; D004987:Ethers; D008081:Liposomes; D004247:DNA; D005990:Glycerol