Four weeks of mobility after 8 weeks of immobility fails to restore normal motion: a preliminary study.
Prolonged immobilization reduces passive range of motion of joints creating joint contractures. Whether and to what extent these iatrogenic contractures can be reduced is unknown. We raised three questions using an animal model: What degree of contracture remains at the end of a defined remobilization period? Do contractures in sham-operated and immobilized joints differ? What is the contribution of the posterior knee capsule in limiting knee extension? We immobilized one knee of 11 adult male rats in flexion to induce a joint contracture; 10 control animals underwent a sham operation. After 8 weeks, the internal fixation device was removed, and the animals were allowed to resume unrestricted activity for 4 weeks at the end of which the knee range of motion was measured with standardized torques. The mean flexion contracture was higher in the immobilized group (51.9 degrees +/- 2.8 degrees ) than in the sham-operated group (18.9 degrees +/- 2.1 degrees ). Eighty-eight percent of the contractures remained in the immobilized group after dividing skin and muscle, suggesting an important contribution of the posterior knee capsule in limiting knee mobility. Based on our preliminary study the range of motion of rat knees immobilized for 8 weeks remained substantially reduced after a 4-week period of unassisted remobilization.
Trudel
Guy
G
Bone and Joint Laboratory, University of Ottawa, Ottawa, ON, Canada.
Zhou
Jian
J
Uhthoff
Hans K
HK
Laneuville
Odette
O
D000818:Animals; D003286:Contracture / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D007103:Immobilization / Q000009:adverse effects; D017746:Joint Capsule / Q000503:physiopathology*; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D010865:Pilot Projects; D016059:Range of Motion, Articular; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D013997:Time Factors; D019415:Torque