14-3-3 proteins in Echinococcus: their role and potential as protective antigens.
14-3-3 Proteins are a family of highly conserved proteins among all eukaryotic organisms studied so far. As basically intracellular proteins, they play a key role in basic cellular events related to cellular proliferation, including signal transduction, cell-cycle control, cell differentiation and cell survival. The 14-3-3 proteins have been described and characterized in several parasites, and mostly studied in Echinococcus granulosus and Echinococcus multilocularis. Here, we review the discoveries regarding this protein family in the genus Echinococcus, describing new data about specific aspects related with their implication in the parasite biology and immunology in the frame of the host-parasite relationship.
Siles-Lucas
Mar
M
Unidad de Patología Animal, Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA), Consejo Superior de Investigaciones Científicas (CSIC), Cordel de Merinas 40-52, 37008 Salamanca, Spain.
Merli
Michael
M
Department of Parasitology, University of Hohenheim, Stuttgart, Germany.
Gottstein
Bruno
B
Institute of Parasitology, University of Berne, Länggass Strasse 122, CH-3001 Berne, Switzerland.
D048948:14-3-3 Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000276:immunology; D000947:Antigens, Helminth / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D004443:Echinococcosis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D004446:Echinococcus / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D010802:Phylogeny; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D014612:Vaccines / Q000737:chemistry / Q000235:genetics / Q000276:immunology
D048948:14-3-3 Proteins; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015801:Helminth Proteins; D020033:Protein Isoforms; D014612:Vaccines