title: [Subchronic toxic effects of fish muscle-bound MCLR].
abstract: Subchronic oral gavage toxicity of MCLR in water and in fish muscle was examined in male Balb/C mice for 13 weeks to assess the safety of aquatic products. The results showed that the liver coefficient (p < 0.05), the activities of ALT and AST (p < 0.01) increased significantly and distinct centrilobular to midzonal hepatucellular occurred after oral gavage of dissolved MCLR at a dose of 68.75 microg/kg (body weight), but neither influence on the activities of BUN and Cr nor histological changes on kidney were observed at any time point. In contrast, the administration of fish muscle-bound MCLR at the same dose resulted in no obvious subchronic toxicity in mice, except that the increase of liver coefficient (p < 0.05) and the activity of ALT (p < 0.01) can be observed only at the first week. It was concluded that the toxicity of fish muscle-bound MCLR was much lower than that of dissolved MCLR.
authors.affiliation: College of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan 430070, China. sail_neptune@hotmail.com
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Bang-ding
authors.initials: BD
authors.lastname: Xiao
authors.forename: Xiao-guo
authors.initials: XG
authors.lastname: Chen
authors.forename: Xing-qiang
authors.initials: XQ
authors.lastname: Wu
authors.forename: Min
authors.initials: M
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002857:Chromium / Q000032:analysis; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis* / Q000517:prevention & control; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008387:Marine Toxins; D051379:Mice; D008807:Mice, Inbred BALB C; D052998:Microcystins / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D017747:Seafood / Q000032:analysis; D018675:Toxicity Tests / Q000379:methods*; D014873:Water Pollutants / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity
chemical_list: D008387:Marine Toxins; D052998:Microcystins; D014873:Water Pollutants; D002857:Chromium; C057862:cyanoginosin LR