title: An update on the management of anticoagulated patients programmed for dental extractions and surgery.
abstract: Oral anticoagulants (OACs) antagonizing vitamin K - fundamentally sodium warfarin and acenocoumarol - are widely used for preventing arterial thromboembolism in patients with atrial fibrillation and/or heart valve prostheses, and for the treatment and prevention of deep venous thrombosis and pulmonary embolism. The handling of these drugs requires correct monitorization and dose adjustment to obtain the desired therapeutic effect while minimizing the adverse effects associated both with excessive anticoagulation (which leads to bleeding) and with insufficient antithrombotic action (which can produce thrombosis). This is particularly important when patients must be subjected to surgical procedures such as tooth extractions. In this context, a number of management recommendations are available. The present study offers an update on the recommendations for the management of anticoagulated patients programmed for tooth extractions. In recent years, most studies do not recommend reducing or interrupting anticoagulation, or replacing it with heparin, prior to tooth extraction - provided therapeutic international normalized ration (INR) levels are maintained, with emphasis on the application of local measures such as antifibrinolytic agents, for the control of hemostasia.
authors.affiliation: Oral Medicine, Valencia University, Spain. Yolanda.Jimenez@uv.es
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jiménez
authors.forename: Rafael
authors.initials: R
authors.lastname: Poveda
authors.forename: Carmen
authors.initials: C
authors.lastname: Gavaldá
authors.forename: María
authors.initials: M
authors.lastname: Margaix
authors.forename: Gracia
authors.initials: G
authors.lastname: Sarrión
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage*; D016903:Drug Monitoring; D006801:Humans; D019647:Oral Surgical Procedures; D012307:Risk Factors; D014081:Tooth Extraction
chemical_list: D000925:Anticoagulants