The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme.
Heme oxygenase-1 (HO-1) is the rate-limiting enzyme of ferroheme metabolic pathway, which has the functions of anti-oxidation, anti-inflammatory, anti-apoptosis and anti-smooth muscle hyperplasia. Furthermore, HO-1 exerts a protective action in the diseases mediated by effector T lymphocytes such as T helper (Th) 1, Th2 and Th17. In addition, regulatory T cells (Treg) control the activity of CD4+CD25- effector cells in a suppressive manner. Numerous studies indicate that the protective action of HO-1 in diseases is through CD4+CD25+ Treg. This paper will review the current research and understanding of HO-1's role in T cells-mediated immunoregulation.
Xia
Z W
ZW
Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 200025, Shanghai, China. xzw63@hotmail.com
Zhong
W W
WW
Meyrowitz
J S
JS
Zhang
Z L
ZL
D000818:Animals; D051547:Heme Oxygenase-1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007154:Immune System Diseases / Q000201:enzymology / Q000276:immunology; D007111:Immunity, Cellular; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000201:enzymology / Q000276:immunology; D018417:Th1 Cells / Q000201:enzymology / Q000276:immunology; D018418:Th2 Cells / Q000201:enzymology / Q000276:immunology
D051547:Heme Oxygenase-1