Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple.
A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This procedure employs a highly enantioselective lipase from Pseudomonas stutzeri (trade name, lipase TL) as the resolution catalyst and a ruthenium complex as the racemization catalyst. Sixteen 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields (95-97%) and high enantiomeric excesses (96-99%).
Kim
Mahn-Joo
MJ
Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784, Korea. mjkim@postech.ac.kr
Choi
Yoon Kyung
YK
Kim
Sol
S
Kim
Daeho
D
Han
Kiwon
K
Ko
Soo-Byung
SB
Park
Jaiwook
J
D000431:Ethanol / Q000031:analogs & derivatives*; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000431:Ethanol; D012428:Ruthenium; D008049:Lipase