title: Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer.
abstract: Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.
authors.affiliation: Metastasis Research Laboratory, University of Liege, Tour de Pathologie, -1, Bât. B23, Sart Tilman via 4000 Liège, Belgium.
authors.forename: Akeila
authors.initials: A
authors.lastname: Bellahcène
authors.forename: Vincent
authors.initials: V
authors.lastname: Castronovo
authors.forename: Kalu U E
authors.initials: KU
authors.lastname: Ogbureke
authors.forename: Larry W
authors.initials: LW
authors.lastname: Fisher
authors.forename: Neal S
authors.initials: NS
authors.lastname: Fedarko
mesh_terms: D000818:Animals; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic; D053495:Osteopontin / Q000096:biosynthesis; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
chemical_list: D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D016023:Integrins; D008024:Ligands; D010750:Phosphoproteins; D053495:Osteopontin