title: Proline-mediated enantioselective construction of tetrahydropyrans via a domino aldol/acetalization reaction.
abstract: Highly enantioselective synthesis of tetrahydropyrans was accomplished via a domino proline-mediated aldol reaction/intramolecular acetal formation from an aldehyde and inexpensive aqueous tetrahydro-2H-pyran-2,6-diol as a five-carbon unit.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
authors.forename: Damien
authors.initials: D
authors.lastname: Hazelard
authors.forename: Hayato
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hashizume
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D011714:Pyrans; D011392:Proline