IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants.
We analyzed polymorphisms of IL-10 -1082 G/A, IL-18 -137 G/C, TLR4 +896 A/G, and IFNG +874 T/A in 139 infants under 6 months of age hospitalized with bronchiolitis and 400 unselected blood donors. Causative viruses were determined by PCR. Infants with bronchiolitis associated with a virus other than respiratory syncytial virus (N = 18), were more often IL-10 -1082 allele G non-carriers, that is, homozygous for allele A (AA) than controls (66.7% vs. 28.0%, P < 0.0001). Infants with RSV bronchiolitis did not differ from controls. This finding suggests a different pathogenic mechanism for RSV bronchiolitis as compared with wheezing associated with other viral infections, for example, rhinovirus in infants under 6 months of age.
Helminen
Merja
M
Paediatric Research Centre, Tampere University and University Hospital, Tampere, Finland. merja.helminen@fimnet.fi
Nuolivirta
Kirsi
K
Virta
Miia
M
Halkosalo
Anne
A
Korppi
Matti
M
Vesikari
Timo
T
Hurme
Mikko
M
D000483:Alleles; D001990:Bronchiolitis, Viral / Q000235:genetics* / Q000276:immunology / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006720:Homozygote; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012229:Rhinovirus / Q000302:isolation & purification; D012720:Severity of Illness Index
D016753:Interleukin-10