Microtubule dynamics regulated by stathmin.
Microtubules perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin-tubulin interaction gradients. Computer simulation of the model with stathmin-tubulin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin-tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored.
Budhachandra
Kh
Kh
Computational Neuroscience and Neuroimaging Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India.
Brojen Singh
R K
RK
Menon
G I
GI
D003198:Computer Simulation; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure*; D008954:Models, Biological; D050777:Stathmin / Q000378:metabolism*
D050777:Stathmin