title: Comparison of prevalence of >70% diameter narrowing of one or more major coronary arteries in patients with versus without mitral annular calcium and clinically suspected coronary artery disease.
abstract: The prevalence of >70% narrowing of 1, 2, or 3 major coronary arteries and of 3 major coronary arteries was investigated in 2,465 patients (1,437 men, 1,028 women; mean age 69 +/- 13 years) with severe, moderate, mild, or no mitral annular calcium (MAC) diagnosed by 2-dimensional echocardiography who underwent coronary angiography for suspected coronary artery disease. Greater than 70% narrowing of 1, 2, or 3 major coronary arteries was present in 259 of 315 patients (82%) with severe MAC (group 1), in 835 of 1,052 patients (79%) with moderate or mild MAC (group 2), and in 756 of 1,098 patients (69%) with no MAC (group 3) (p <0.001 comparing group 1 with group 3 and group 2 with group 3). Greater than 70% narrowing of 3 major coronary arteries was present in 149 of 315 patients (47%) in group 1, in 366 of 1,052 patients (35%) in group 2, and in 325 of 1,098 patients (30%) in group 3 (p <0.001 comparing group 1 with group 3 and group 1 with group 2; p <0.01 comparing group 2 with group 3). In conclusion, MAC is associated with obstructive >or=1-vessel coronary artery disease and with obstructive 3-vessel coronary artery disease.
authors.affiliation: Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York, USA.
authors.forename: Hari
authors.initials: H
authors.lastname: Kannam
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.forename: Kiran
authors.initials: K
authors.lastname: Chilappa
authors.forename: Tarunjit
authors.initials: T
authors.lastname: Singh
authors.forename: John A
authors.initials: JA
authors.lastname: McClung
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Pucillo
authors.forename: Melvin B
authors.initials: MB
authors.lastname: Weiss
authors.forename: Kumar
authors.initials: K
authors.lastname: Kalapatapu
authors.forename: Thomas
authors.initials: T
authors.lastname: Sullivan
authors.forename: Craig E
authors.initials: CE
authors.lastname: Monsen
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D015995:Prevalence; D012720:Severity of Illness Index; D014463:Ultrasonography