title: Comparative study of conventional colonoscopy and pan-colonic narrow-band imaging system in the detection of neoplastic colonic polyps: a randomized, controlled trial.
abstract: BACKGROUND
  Detection and removal of adenomas by colonoscopy is an important means for preventing cancer; however, small adenomas may be missed during colonoscopy. The narrow-band imaging (NBI) system clearly enhances the microvasculature in neoplastic lesions, making it appear as a dark complex. Therefore, the NBI system may improve the detection of colonic neoplasias. However, no randomized, controlled trials have evaluated the efficacy of a pan-colonic NBI system in adenoma detection. We conducted a randomized, controlled trial to determine the efficacy of the pancolonic NBI system in adenoma detection.
  
  
  METHODS
  Two hundred forty-three patients were randomized, 121 to conventional colonoscopy and 122 to pan-colonic NBI system. Demographics, indication for colonoscopy, and quality of preparation were similar between groups.
  
  
  RESULTS
  Extubation time was not significantly different between the conventional colonoscopy and pan-colonic NBI system. The proportions of patients with at least one adenoma and those with multiple adenomas were not significantly different between groups. However, the pan-colonic NBI system significantly increased the total number of adenomas detected (P < 0.05) and the number of diminutive (<5 mm) adenomas detected (P < 0.05). The pan-colonic NBI system allowed detection of more diminutive adenomas in the distal colon than did conventional colonoscopy (P < 0.01), and more patients in the NBI group had at least one diminutive adenoma than in the control group (P < 0.05).
  
  
  CONCLUSIONS
  The pan-colonic NBI system improves the total number of adenomas detected, including significantly more diminutive adenomas, without prolongation of extubation time. These results indicate that routine use of the NBI system for surveillance of diminutive adenomas may be recommended.
authors.affiliation: Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, 569-8686, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Inoue
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Murano
authors.forename: Naoko
authors.initials: N
authors.lastname: Murano
authors.forename: Takanori
authors.initials: T
authors.lastname: Kuramoto
authors.forename: Ken
authors.initials: K
authors.lastname: Kawakami
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Abe
authors.forename: Eijiro
authors.initials: E
authors.lastname: Morita
authors.forename: Ken
authors.initials: K
authors.lastname: Toshina
authors.forename: Hideo
authors.initials: H
authors.lastname: Hoshiro
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Egashira
authors.forename: Eiji
authors.initials: E
authors.lastname: Umegaki
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D001706:Biopsy; D003111:Colonic Polyps / Q000473:pathology*; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D014741:Video Recording / Q000295:instrumentation