title: [The modulation of mitochondrial pore sensitivity of isolated myocardial preparations to the action of phenylarsenoxide].
abstract: In the experiments with coperfused isolated ring strips from a. carotis (A) and trabecule (T) from the right auricle of guinea pigs it has been shown the modification of a sensitivity of mitochondrial pore (MP) to the action of its activators. Exogenous NO-donor-sodium nitroprusside and hypoxic precondition (HP) caused a protective action on myocardium and arterial vessels isolated preparations of the old animals due to reducing of a myocardium MP sensitivity. While the contractile response to control electric stimulation T and A of the trained animals was almost twice lower in comparison to the group untraining ones, which can be evidence of the resources depleted of myocardium and vessels preparations caused by hypoxic training of the old animals.
authors.forename: A V
authors.initials: AV
authors.lastname: Dmytriieva
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Bubnova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Bohuslavs'kyĭ
authors.forename: V F
authors.initials: VF
authors.lastname: Sahach
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001152:Arsenicals / Q000494:pharmacology*; D017536:Carotid Artery, Common / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D006168:Guinea Pigs; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D066298:In Vitro Techniques; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D009119:Muscle Contraction / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology
chemical_list: D001152:Arsenicals; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; C029341:oxophenylarsine; D009599:Nitroprusside; D009569:Nitric Oxide