title: Synthesis, characterization of some transition metal(II) complexes of acetone p-amino acetophenone salicyloyl hydrazone and their anti microbial activity.
abstract: Complexes of the type [M(apash)Cl] and [M(Hapash)(H2O)SO4], where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II); Hapash = acetone p-amino acetophenone salicyloyl hydrazone have been synthesized and characterized by elemental analyses, molar conductance, magnetic moments, electronic, ESR and IR spectra, thermal studies (TGA & DTA) and X-ray diffraction studies. The ligand coordinates through two >C=N and a deprotonated enolate group in all the chloro complexes, whereas through two >C=N- and a >C=O group in all the sulfato complexes. The electronic spectra suggest a square planar geometry for Co(II), Ni(II) and Cu(II) chloride complexes and an octahedral geometry for the sulfate complexes. ESR data show an isotropic symmetry for [Cu(apash)Cl] and [Cu(Hapash)(H2O)SO4] in solid state. However, ESR spectra of both Cu(II) complexes indicate the presence of unpaired electron in d x2-y2. The X-ray diffraction parameters for [Co(apash)Cl] and [Cu(Hapash)(H2O)SO4] complexes correspond to a tetragonal and an orthorhombic crystal lattices, respectively. Thermal studies of [Co(apash)Cl] complex shows a multi-step decomposition pattern. Most of the complexes show better antifungal activity than the standard miconazole against a number of pathogenic fungi. The antibacterial activity of these complexes has been evaluated against E. coli and Clostridium sp. which shows a moderate activity.
authors.affiliation: Chemistry Department, Faculty of Science, Banaras Hindu University, Varanasi, India. singvp@yahoo.co.in
authors.forename: Vinod P
authors.initials: VP
authors.lastname: Singh
authors.forename: Anshu
authors.initials: A
authors.lastname: Katiyar
authors.forename: Shweta
authors.initials: S
authors.lastname: Singh
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000098:Acetophenones / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000890:Anti-Infective Agents; D006835:Hydrazones; D008670:Metals; D028561:Transition Elements; D000096:Acetone; C066837:acetone hydrazone