Meibomian gland alterations in polycystic ovary syndrome.
OBJECTIVE
Polycystic ovary syndrome (PCOS) is an endocrinopathy characterized by chronic anovulation and hyperandrogenism where hyperinsulinemia can be seen. Hormonal changes can affect meibomian gland function. In this study, we evaluated tear function in PCOS.


METHODS
Twenty-seven women having PCOS and 22 normal individuals aged between 18-42 years were enrolled in the study. Patients were asked about dry eye symptoms. Schirmer test, tear film breakup time, and rose Bengal staining were performed. Conjunctival brush cytology specimens were obtained and goblet cell count was done.


RESULTS
Dry eye symptoms were more frequent in subjects with PCOS (p=0.025). Mean breakup time was shorter in women with PCOS (p=0.034). Schirmer test results, rose Bengal staining scores, and goblet cell count were not different between groups (p=0.48, p=0.18, p=0.82, respectively).


CONCLUSIONS
Meibomian gland function and tear film lipid layer can be affected in cases with PCOS.
Yavas
Guliz Fatma
GF
School of Medicine, Department of Ophthalmology, Afyon Kocatepe University, Afyonkarahisar, Turkey. gkumbar@ttnet.net.tr
Ozturk
Faruk
F
Kusbeci
Tuncay
T
Ermis
Sitki Samet
SS
Yilmazer
Mehmet
M
Cevrioglu
Serhan
S
Aktepe
Fatma
F
Kose
Songul
S
D000328:Adult; D002452:Cell Count; D015352:Dry Eye Syndromes / Q000503:physiopathology*; D005141:Eyelid Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008537:Meibomian Glands / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D013666:Tears / Q000502:physiology