A norsesquiterpene lactone and a benzoic acid derivative from the leaves of Cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activities.
Two novel compounds, 3-methoxypterolactone ( 1) and 2-amino-3,4-dihydroxy-5-methoxybenzoic acid ( 2), were isolated from leaves of Cyclocarya paliurus (Batal.) Iljinsk, together with nine known compounds: pterolactone ( 3), gallic acid ( 4), 4-hydroxy-3-methoxybenzoic acid ( 5), oleanolic acid ( 6), beta-boswellic acid ( 7), alpha-boswellic acid ( 8), beta-amyrin ( 9), beta-amyrone ( 10) and 3beta-O-trans-caffeoyl-morolic acid ( 11). The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments ( (1)H- (1)H COSY, HMQC and HMBC). All isolated compounds were evaluated for their glycosidase and glycogen phosphorylase inhibitory activities. 2-Amino-3,4-dihydroxy-5-methoxybenzoic acid and gallic acid showed significant alpha-glucosidase and glycogen phosphorylase inhibitory activities.
Li
Jun
J
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, P. R. China.
Lu
Yuanyuan
Y
Su
Xiaojian
X
Li
Fu
F
She
Zhigang
Z
He
Xingcun
X
Lin
Yongcheng
Y
D001565:Benzoates / Q000302:isolation & purification / Q000494:pharmacology*; D005707:Gallic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors; D062425:Hydroxybenzoate Ethers; D029525:Juglandaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
C530125:2-amino-3,4-dihydroxy-5-methoxybenzoic acid; D001565:Benzoates; D065089:Glycoside Hydrolase Inhibitors; D062425:Hydroxybenzoate Ethers; D005707:Gallic Acid; D024981:Glycogen Phosphorylase