title: Applications of the combination of microwave and parallel synthesis in medicinal chemistry.
abstract: The blending of microwave heating and parallel chemistry is a logical consequence of the significant rate enhancement and higher product yield afforded by microwave technology and the increase in productivity afforded by combinatorial chemistry. For this reason, this combination has become increasingly popular in the organic chemistry community. The current review highlights the application of this approach as a way to increase the rate of analogue synthesis in medicinal chemistry.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, Division of Janssen-Cilag, S.A. Jarama 75, Toledo, Spain. jalcazar@prdes.jnj.com
authors.forename: Jesús
authors.initials: J
authors.lastname: Alcázar
authors.forename: Gaston
authors.initials: G
authors.lastname: Dielsb
authors.forename: Bruno
authors.initials: B
authors.lastname: Schoentjes
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008872:Microwaves; D008956:Models, Chemical; D009930:Organic Chemicals / Q000138:chemical synthesis*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
chemical_list: D009930:Organic Chemicals; D004364:Pharmaceutical Preparations