title: Randomized comparison of distal protection versus conventional treatment in primary percutaneous coronary intervention: the drug elution and distal protection in ST-elevation myocardial infarction (DEDICATION) trial.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the use of distal protection during percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in native coronary vessels.
  
  
  BACKGROUND
  Embolization of material from the infarct-related lesion during PCI may result in impaired myocardial perfusion and worsen the prognosis. Previous attempts to protect the microcirculation during primary PCI have had conflicting results.
  
  
  METHODS
  We randomly assigned 626 patients with STEMI referred within 12 h to have PCI performed with (n = 312) or without (n = 314) distal protection. The primary end point was complete (>or=70%) ST-segment resolution detected by continuous ST-segment monitoring. Blood levels of troponin-T and creatine kinase-MB were monitored before and after the procedure, and echocardiographic determination of the left ventricular wall motion index (WMI) was performed before discharge.
  
  
  RESULTS
  Patients were well matched in terms of demographic and angiographic baseline characteristics. There was no significant difference in the occurrence of the primary end point (76% vs. 72%, p = 0.29), no difference in maximum troponin-T (4.8 microg/l and 5.0 microg/l, p = 0.87) or maximum creatine kinase-MB (185 microg/l and 184 microg/l, p = 0.99), and no difference in median WMI (1.70 vs. 1.70, p = 0.35). The rate of major adverse cardiac and cerebral events (MACCE) 1 month after PCI was 5.4% with distal protection and 3.2% with conventional treatment (p = 0.17).
  
  
  CONCLUSIONS
  The routine use of distal protection by a filterwire system during primary PCI does not seem to improve microvascular perfusion, limit infarct size, or reduce the occurrence of MACCE.
authors.affiliation: Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Kelbaek
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Terkelsen
authors.forename: Steffen
authors.initials: S
authors.lastname: Helqvist
authors.forename: Jens F
authors.initials: JF
authors.lastname: Lassen
authors.forename: Peter
authors.initials: P
authors.lastname: Clemmensen
authors.forename: Lene
authors.initials: L
authors.lastname: Kløvgaard
authors.forename: Anne
authors.initials: A
authors.lastname: Kaltoft
authors.forename: Thomas
authors.initials: T
authors.lastname: Engstrøm
authors.forename: Hans E
authors.initials: HE
authors.lastname: Bøtker
authors.forename: Kari
authors.initials: K
authors.lastname: Saunamäki
authors.forename: Lars R
authors.initials: LR
authors.lastname: Krusell
authors.forename: Erik
authors.initials: E
authors.lastname: Jørgensen
authors.forename: Hans-Henrik T
authors.initials: HH
authors.lastname: Hansen
authors.forename: Evald H
authors.initials: EH
authors.lastname: Christiansen
authors.forename: Jan
authors.initials: J
authors.lastname: Ravkilde
authors.forename: Lars
authors.initials: L
authors.lastname: Køber
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Kofoed
authors.forename: Leif
authors.initials: L
authors.lastname: Thuesen
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D017225:Atherectomy, Coronary / Q000295:instrumentation*; D003328:Coronary Thrombosis / Q000628:therapy*; D054855:Drug-Eluting Stents; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome