title: Fifteen-year, single-center experience with the surgical management of intrahepatic cholangiocarcinoma: operative results and long-term outcome.
abstract: BACKGROUND
  Limited data exist regarding the role of extended liver resection for the management of intrahepatic cholangiocarcinoma (ICC), most of which derive from small single-center or larger multicenter series. In the current report, we present our experience with the surgical management of ICC, analyze operative results, and investigate prognostic factors in resected patients.
  
  
  METHODS
  A total of 72 patients underwent operative exploration for ICC between 1991 and 2005; 54 patients were resected, and 18 patients were deemed unresectable based on intraoperative findings. Demographics, pathology, anatomic characteristics, operative results, and survival were analyzed.
  
  
  RESULTS
  The resectability rate was 71%, with negative margins achieved in 78% of the resected patients. Extended liver resections were performed in 24 (44%) of the 72 patients. Perioperative mortality after resection was 7%, with 11% morbidity. The 1-, 3- and 5-year survival rates after resection were 80%, 49% and 25%, respectively, and were significantly greater than for patients with unresectable disease (P < .001). R1 liver resections conferred increased 5-year survival compared with patients deemed unresectable (P = .03). None of the factors evaluated proved to be independent prognostic factors on multivariate analysis.
  
  
  CONCLUSIONS
  R0 resection of ICC provides the best chance for prolonged survival, whereas R1 resection appears to be superior to nonoperative treatment. Declining operative mortality as a result of improved intraoperative and perioperative care justifies the performance of extended liver resections in these patients, although benefit has to be evaluated with respect to nodal involvement.
authors.affiliation: Recanati-Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY, USA. manousos.konstadoulakis@mountsinai.org
authors.forename: Manousos M
authors.initials: MM
authors.lastname: Konstadoulakis
authors.forename: Sasan
authors.initials: S
authors.lastname: Roayaie
authors.forename: Ilias P
authors.initials: IP
authors.lastname: Gomatos
authors.forename: Daniel
authors.initials: D
authors.lastname: Labow
authors.forename: Maria-Isabell
authors.initials: MI
authors.lastname: Fiel
authors.forename: Charles M
authors.initials: CM
authors.lastname: Miller
authors.forename: Myron E
authors.initials: ME
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D015999:Multivariate Analysis; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome