title: Frequency and clinical profile of patients with polycystic kidney disease in southern Brazil.
abstract: BACKGROUND
  Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic nephropathies, affecting one in every 800-1000 individuals in the worldwide general population and 5-10% of hemodialysis patients. Little data concerning the prevalence of ADPKD in Brazil are available. Thus, the aim of the present study was to investigate both the frequency and clinical profile of ADPKD among hemodialysis patients in south of Brazil.
  
  
  METHODS
  This cross-sectional study consisted of patients from 24 hemodialysis centers. Patients were screened for ADPKD by clinical, laboratorial, and image examination in medical records.
  
  
  RESULTS
  Of 1326 patients on hemodialysis in the south of Brazil that composed this study, 99 (7.5%) had polycystic kidney as primary cause for chronic renal failure. Comparisons between ADPKD and non-ADPKD patients revealed no differences regarding mean age, gender, and ethnicity.
  
  
  CONCLUSIONS
  Our data revealed that ADPKD is prevalent among patients on hemodialysis in the south of Brazil. In addition, the clinical profile of ADPKD is similar to reported data from North America and Europe, putatively due to the similar ethnic composition mainly based on European descents.
authors.affiliation: Laboratory of Cellular, Genetics and Molecular Nephrology/ LIM-29, Division of Nephrology, São Paulo University Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Ane Cláudia Fernandes
authors.initials: AC
authors.lastname: Nunes
authors.forename: Vagner
authors.initials: V
authors.lastname: Milani
authors.forename: Daiana Benck
authors.initials: DB
authors.lastname: Porsch
authors.forename: Liana Bertolin
authors.initials: LB
authors.lastname: Rossato
authors.forename: Cristiane Bastos
authors.initials: CB
authors.lastname: Mattos
authors.forename: Israel
authors.initials: I
authors.lastname: Roisenberg
authors.forename: Elvino José Guardão
authors.initials: EJ
authors.lastname: Barros
mesh_terms: D000328:Adult; D017677:Age Distribution; D000704:Analysis of Variance; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D011336:Probability; D011379:Prognosis; D006435:Renal Dialysis / Q000706:statistics & numerical data; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome