Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples.
BACKGROUND
Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus


METHODS
The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated.


RESULTS
Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age.


CONCLUSIONS
Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.
Ferreccio
Catterina
C
P. Universidad Católica de Chile, Escuela de Medicina, Santiago Chile. cferrec@med.puc.cl
Corvalán
Alejandro
A
Margozzini
Paula
P
Viviani
Paola
P
González
Claudia
C
Aguilera
Ximena
X
Gravitt
Patti E
PE
D000293:Adolescent; D000328:Adult; D002677:Chile / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D014626:Vaginal Smears