title: Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area.
abstract: Fine particulate matter (PM(2.5)) is associated with respiratory effects, and asthmatic children are especially sensitive. Preliminary evidence suggests that combustion-derived particles play an important role. Our objective was to evaluate effect estimates from different PM(2.5) exposure metrics in relation to airway inflammation and lung function among children residing in woodsmoke-impacted areas of Seattle. Nineteen children (ages 6-13 yr) with asthma were monitored during the heating season. We measured 24-h outdoor and personal concentrations of PM(2.5) and light-absorbing carbon (LAC). Levoglucosan (LG), a marker of woodsmoke, was also measured outdoors. We partitioned PM(2.5) exposure into its ambient-generated (E(ag)) and nonambient (E(na)) components. These exposure metrics were evaluated in relation to daily changes in exhaled nitric oxide (FE(NO)), a marker of airway inflammation, and four lung function measures: midexpiratory flow (MEF), peak expiratory flow (PEF), forced expiratory volume in the first second (FEV(1)), and forced vital capacity (FVC). E(ag), but not E(na), was correlated with combustion markers. Significant associations with respiratory health were seen only among participants not using inhaled corticosteroids. Increases in FE(NO) were associated with personal PM(2.5), personal LAC, and E(ag) but not with ambient PM(2.5) or its combustion markers. In contrast, MEF and PEF decrements were associated with ambient PM(2.5), its combustion markers, and E(ag), but not with personal PM(2.5) or personal LAC. FEV(1) was associated only with ambient LG. Our results suggest that lung function may be especially sensitive to the combustion-generated component of ambient PM(2.5), whereas airway inflammation may be more closely related to some other constituent of the ambient PM(2.5) mixture.
authors.affiliation: Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada. allenr@sfu.ca
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Allen
authors.forename: Therese
authors.initials: T
authors.lastname: Mar
authors.forename: Jane
authors.initials: J
authors.lastname: Koenig
authors.forename: L-J Sally
authors.initials: LJ
authors.lastname: Liu
authors.forename: Timothy
authors.initials: T
authors.lastname: Gould
authors.forename: Christopher
authors.initials: C
authors.lastname: Simpson
authors.forename: Timothy
authors.initials: T
authors.lastname: Larson
mesh_terms: D000293:Adolescent; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000378:metabolism / Q000503:physiopathology*; D002648:Child; D002947:Cities; D004784:Environmental Monitoring; D005947:Glucose / Q000031:analogs & derivatives / Q000032:analysis; D006801:Humans; D007249:Inflammation; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism; D052638:Particulate Matter / Q000009:adverse effects* / Q000032:analysis; D012129:Respiratory Function Tests; D012906:Smoke; D014505:Urban Population; D014934:Wood
chemical_list: D052638:Particulate Matter; D012906:Smoke; D009569:Nitric Oxide; C014989:1,6-anhydro-beta-glucopyranose; D005947:Glucose