Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study.
We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.
Robertson
Marli A
MA
Department of Pediatrics, University of Calgary, Calgary, AB, Canada. marli.robertson@calgaryhealthregion.ca
Sigalet
David L
DL
Holst
Jens J
JJ
Meddings
Jon B
JB
Wood
Julie
J
Sharkey
Keith A
KA
D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005260:Female; D053767:Glucagon-Like Peptide 2 / Q000097:blood*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D007421:Intestine, Small / Q000503:physiopathology; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism; D010865:Pilot Projects; D012016:Reference Values; D012528:Satiety Response / Q000502:physiology
D053767:Glucagon-Like Peptide 2; D008353:Mannitol; D007792:Lactulose