Halogenation strategies in natural product biosynthesis.
Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.
Neumann
Christopher S
CS
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Fujimori
Danica Galonić
DG
Walsh
Christopher T
CT
D001688:Biological Products / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D054879:Halogenation; D006219:Halogens / Q000378:metabolism; D005810:Multigene Family; D010544:Peroxidases / Q000378:metabolism
D001688:Biological Products; D006219:Halogens; D010544:Peroxidases