Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS.
Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.
Bae
Jinhee
J
College of Natural Sciences, Kangwon National University, Chunchon 200-701, Korea.
Park
Deokbum
D
Lee
Yun-Sil
YS
Jeoung
Dooil
D
D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018919:Neovascularization, Physiologic; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014471:Umbilical Veins / Q000502:physiology
D042501:Angiogenic Proteins; D007376:Interleukin-2; D017382:Reactive Oxygen Species; D051057:Proto-Oncogene Proteins c-akt