title: Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease.
abstract: Alzheimer's disease is a progressive and fatal neurodegenerative disorder manifested by cognitive and memory deterioration, progressive impairment of activities of daily living, and a variety of neuropsychiatric symptoms and behavioral disturbances. Alzheimer's disease affects 15 million people worldwide and it has been estimated that Alzheimer's disease affects 4.5 million Americans. Rivastigmine is a reversible cholinesterase inhibitor used for the treatment of Alzheimer's disease. Central nervous system drug efficacy depends upon the ability of a drug to cross the blood-brain barrier and reach therapeutic concentrations in brain following systemic administration. The clinical failures of most of the potentially effective therapeutics to treat the central nervous system disorders are often not due to a lack of drug potency but rather shortcomings in the method by which the drug is delivered. Hence, considering the importance of treating Alzheimer's disease, we made an attempt to target the anti-Alzheimer's drug rivastigmine in the brain by using poly(n-butylcyanoacrylate) nanoparticles. The drug was administered as a free drug, bound to nanoparticles and also bound to nanoparticles coated with polysorbate 80. In the brain a significant increase in rivastigmine uptake was observed in the case of poly(n-butylcyanoacrylate) nanoparticles coated with 1% polysorbate 80 compared to the free drug. In conclusion that the present study demonstrates that the brain concentration of intravenously injected rivastigmine can be enhanced over 3.82 fold by binding to poly(n-butylcyanoacrylate) nanoparticles coated with 1% nonionic surfactant polysorbate 80.
authors.affiliation: Department of Pharmaceutics, J.S.S. College of Pharmacy, Rocklands, Ootacamund, Tamil Nadu-643001, India. b_wilson@rediffmaill.com
authors.forename: Barnabas
authors.initials: B
authors.lastname: Wilson
authors.forename: Malay Kumar
authors.initials: MK
authors.lastname: Samanta
authors.forename: Kumaraswamy
authors.initials: K
authors.lastname: Santhi
authors.forename: Kokilampal Perumal Sampath
authors.initials: KP
authors.lastname: Kumar
authors.forename: Nallupillai
authors.initials: N
authors.lastname: Paramakrishnan
authors.forename: Bhojraj
authors.initials: B
authors.lastname: Suresh
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000379:methods*; D004659:Enbucrilate / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D048448:Phenylcarbamates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011136:Polysorbates / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000068836:Rivastigmine; D013501:Surface-Active Agents / Q000737:chemistry / Q000627:therapeutic use; D015854:Up-Regulation / Q000502:physiology
chemical_list: D002800:Cholinesterase Inhibitors; D048448:Phenylcarbamates; D011136:Polysorbates; D013501:Surface-Active Agents; D004659:Enbucrilate; D000068836:Rivastigmine