title: Anti-Scl-70 antibodies in autoimmune hypothyroidism.
abstract: The relationship between autoimmune thyroiditis and systemic sclerosis is controversial. Data exist on the presence of thyroid autoantibodies in patients with systemic sclerosis but, as far as we could ascertain, anti-Scl-70 antibodies, which are highly specific for systemic sclerosis, have not been investigated in autoimmune hypothyroidism. This study compares the presence of anti-Scl-70 in females with autoimmune hypothyroidism (n = 24) and in healthy age-matched female controls (n = 26). Free thyroxine levels were similar in both groups. Thyroid stimulating hormone (TSH), antithyroid peroxidase (anti-TPO), antithyroglobulin (anti-Tg) and index values for anti-Scl-70 levels were significantly higher in patients with autoimmune hypothyroidism compared with controls, although the anti-Scl-70 test was negative in both groups. Anti-TPO, anti-Tg and TSH significantly correlated with anti-Scl-70. In conclusion, autoimmune hypothyroidism seems to be associated with a higher index level of anti-Scl-70, yet a negative anti-Scl-70 antibody test. This suggests that autoimmune hypothyroidism might have common aetiological factors with systemic sclerosis.
authors.affiliation: Department of Medicine, Medical Faculty, University of Cumhuriyet, Sivas, Turkey. serdalugurlu@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Ugurlu
authors.forename: E
authors.initials: E
authors.lastname: Caglar
authors.forename: T
authors.initials: T
authors.lastname: Yesim
authors.forename: H
authors.initials: H
authors.lastname: Balci
authors.forename: E
authors.initials: E
authors.lastname: Tasan
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D004264:DNA Topoisomerases, Type I; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D007453:Iodide Peroxidase / Q000276:immunology; D009687:Nuclear Proteins / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D001323:Autoantibodies; D009687:Nuclear Proteins; C048100:Scl 70 antigen, human; D013972:Thyrotropin; D013954:Thyroglobulin; D007453:Iodide Peroxidase; D004264:DNA Topoisomerases, Type I; D013974:Thyroxine