Multimerin 1.
Multimerin 1 is a massive, soluble, disulfide-linked homopolymeric protein that is expressed in megakaryocytes, platelets and endothelial cells. Normally, multimerin 1 undergoes efficient sorting to secretion granules, and it is not detectable in plasma. Recently, multimerin 1 was designated as a member of the EMILIN protein family, a group of structurally similar, disulfide-linked multimeric proteins. Multimerin 1 has the structural features of an adhesive protein and it supports the adhesion of many different cell types in vitro, including activated platelets, neutrophils, and endothelial cells. Multimerin 1 also has the ability to self associate and form large, branching matrix fibers. In platelet alpha-granules, multimerin 1 functions as the binding protein for coagulation factor V, a key regulator of coagulation. This review summarizes the current knowledge on multimerin 1 including its orthologous genes, restricted pattern of expression, structure, biosynthesis and functions.
Jeimy
Samira B
SB
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Tasneem
Subia
S
Cramer
Elisabeth M
EM
Hayward
Catherine P M
CP
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D001798:Blood Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D003594:Cytoplasmic Granules / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005165:Factor V / Q000378:metabolism; D006801:Humans; D008533:Megakaryocytes / Q000502:physiology; D015539:Platelet Activation; D010974:Platelet Aggregation; D011485:Protein Binding; D021381:Protein Transport
D001798:Blood Proteins; D016326:Extracellular Matrix Proteins; C069282:multimerin; D005165:Factor V