Wires in the soup: quantitative models of cell signaling.
Living cells are capable of extracting information from their environments and mounting appropriate responses to a variety of challenges. The underlying signal transduction networks enabling this response can be quite complex, and so sophisticated computational modeling coupled with precise experimentation is required to unravel them. Although we are still at the beginning of this process, some recent examples of integrative analysis of cell signaling are very encouraging. Quantitative models of signaling pathways (e.g. NF-kappaB) can be gradually constructed through continuous experimental validation, and important lessons can be learnt from such exercises.
Cheong
Raymond
R
Whitaker Institute for Biomedical Engineering, Institute for Cell Engineering, Department of Biomedical Engineering, Johns Hopkins University, 208C Clark Hall, 3400 North Charles Street, Baltimore, MD 21218, USA.
Levchenko
Andre
A
D000818:Animals; D019295:Computational Biology; D025461:Feedback, Physiological; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D020672:I-kappa B Proteins; D046912:Multiprotein Complexes; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha