title: Oxidative stress in benign prostate hyperplasia.
abstract: Benign Prostate Hyperplasia (BPH) is the common health problem in ageing male. Free radicals and reactive oxygen species (ROS) are produced more with advancement of age leads to oxidative stress. This study aims to assess Malondialdehyde (MDA), the marker of lipid peroxidation and vitaminic antioxidants e.g. alpha-Tocopherol (Toc) and Ascorbate (Asc) status in plasma of BPH patients. This is a case control study conducted in Department of Biochemistry in collaboration with Dept of Surgery, BPKIHS. Forty eight (n = 48) confirmed patients of BPH and forty six (n = 46) healthy age matched controls were enrolled. Plasma MDA, Asc and alpha-Toc were estimated. Plasma MDA level showed 4.81 +/- 1.87 nmol/ml in BPH patients compared to 3.69 +/- 1.56 nmol/ml in healthy controls (p < 0.001). There were significant decrease in plasma alpha-Toc and Asc level which were 0.85 +/- 0.12 mg/dl and 0.93 +/- 0.13 mg/dl in BPH patients compared to 1.37 +/- 0.31 mg/dl and 1.44 +/- 0.38 mg/dl in healthy controls respectively. Inverse correlation of plasma MDA with a- Toc (r = -0.09) and Asc (r = -0.51) was found in BPH patients. There was mild elevation of PSA in BPH patients compared with control but was not statistically significant. Thus, our study showed the evidence of association of oxidative stress in BPH patients.
authors.affiliation: Department of Biochemistry, B.P. Koirala Institute of Health Science, Dharan, Nepal. madhukararyal@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Aryal
authors.forename: A
authors.initials: A
authors.lastname: Pandeya
authors.forename: N
authors.initials: N
authors.lastname: Gautam
authors.forename: N
authors.initials: N
authors.lastname: Baral
authors.forename: M
authors.initials: M
authors.lastname: Lamsal
authors.forename: S
authors.initials: S
authors.lastname: Majhi
authors.forename: L
authors.initials: L
authors.lastname: Chandra
authors.forename: R
authors.initials: R
authors.lastname: Pandit
authors.forename: B K L
authors.initials: BK
authors.lastname: Das
mesh_terms: D000367:Age Factors; D000368:Aged; D001205:Ascorbic Acid; D016022:Case-Control Studies; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011470:Prostatic Hyperplasia / Q000097:blood / Q000503:physiopathology*; D024505:Tocopherols
chemical_list: D008315:Malondialdehyde; D001205:Ascorbic Acid; D024505:Tocopherols