title: Syntheses of manzacidins: a stage for the demonstration of synthetic methodologies.
abstract: Manzacidins, a family of bromopyrrole alkaloids, have attracted much attention from the synthetic community due to their intriguing structures, bearing chiral tertiary and secondary stereocentres in a 1,3-relationship, and biological activities. In this article, we summarise the approaches for the preparation of manzacidins using novel synthetic methodologies. Organocatalysis and Lewis acid catalysis, as well as transition-metal catalysis, offered efficient ways to access these molecules.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka
mesh_terms: D003500:Cyclization; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011743:Pyrimidines; D011758:Pyrroles; C470325:manzacidin A; C520151:manzacidin B; C470326:manzacidin C; C528770:manzacidin D