title: Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
abstract: Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
authors.affiliation: Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France. kamar.n@chu-toulouse.fr
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Janick
authors.initials: J
authors.lastname: Selves
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Mansuy
authors.forename: Leila
authors.initials: L
authors.lastname: Ouezzani
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Péron
authors.forename: Joëlle
authors.initials: J
authors.lastname: Guitard
authors.forename: Olivier
authors.initials: O
authors.lastname: Cointault
authors.forename: Laure
authors.initials: L
authors.lastname: Esposito
authors.forename: Florence
authors.initials: F
authors.lastname: Abravanel
authors.forename: Marie
authors.initials: M
authors.lastname: Danjoux
authors.forename: Dominique
authors.initials: D
authors.lastname: Durand
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vinel
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016751:Hepatitis E / Q000175:diagnosis / Q000635:transmission*; D016752:Hepatitis E virus; D006521:Hepatitis, Chronic / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects