title: Alkaloids from Daphniphyllum oldhami.
abstract: Four new Daphniphyllum alkaloids, daphnioldhanines H-K ( 1- 4), along with 34 known alkaloids, were isolated from Daphniphyllum oldhami. The known alkaloid dehydrodaphnigraciline ( 5) is now reported as a natural product. Their structures were elucidated by spectroscopic methods, especially 2D NMR techniques. The effects against platelet aggregation of compounds 1, 3, and 5 were evaluated, and 3 showed stronger activity against platelet aggregation induced by PAF. This is the first report of quinolizidine alkaloids from the genus Daphniphyllum.
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Guiyang 550002, People's Republic of China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Mu
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Xiao-Sheng
authors.initials: XS
authors.lastname: Yang
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Lie-Jun
authors.initials: LJ
authors.lastname: Huang
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054837:Quinolizidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D054837:Quinolizidines