The "Golden Age" of prostate brachytherapy: a cautionary tale.
OBJECTIVE
To investigate the earliest attempts to use man-made isotopes for prostate brachytherapy.


METHODS
Two radiogold brachytherapy programs were analyzed, using literature review and interviews of participants.


RESULTS
Although (198)Au has been discredited as a source for permanent prostate brachytherapy, the major flaw in the reviewed programs was the misapplication of the isotope.


CONCLUSIONS
Safe and effective implant programs are grounded in the sound application of brachytherapy principles. New brachytherapy procedures should arise from the collaboration of radiation oncologists, surgeons, physicists, radiobiologists, and radiation safety specialists.
Aronowitz
Jesse N
JN
University of Massachusetts Medical School, Worcester, MA 01605, USA. aronowij@ummhc.org
D001918:Brachytherapy / Q000266:history* / Q000379:methods; D006050:Gold Radioisotopes / Q000627:therapeutic use; D049673:History, 20th Century; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D018787:Radiation Oncology / Q000266:history; D011879:Radiotherapy Dosage; D012017:Referral and Consultation; D014572:Urology / Q000266:history
D006050:Gold Radioisotopes