[Improvement effects of Jincao tablet on immune function of model of hysteromyoma in rats].
OBJECTIVE
To investigate the improvement effects of Jincao tablet on immune function of the model of hysteromyoma in rat and the relationship between the model and pathogenesis.


METHODS
Rats were randomly divided into 6 groups: normal group, model group, treatment groups including low,middle and high dosage groups of Jincao tablet and Guizhi Fuling pill. Rats were injected respectively with diethyl stilbestrol and progesterone. The immune apparatus of rats were measured. The levels of CD3, CD4 and CD4/ CD8 in serum were determined by flow cytometer. The estrogen and receptor were measured by radioligand binding assay and pathologic changes of womb tissue were observed microscopically.


RESULTS
Compared with normal group, the weight of thymus, the levels of CD3, CD4 and CD4/CD8 of model group were significantly decreased, and the levels of estrogen, estrogen receptor and CD8 were obviously increased. Jincao tablet groups were significant difference compared with model group and could alleviate the pathological changes of womb tissue.


CONCLUSIONS
Jincao tablet could improve the levels of immune function of the model of hysteromyoma in rat, and it might play a role in the pathogenesis of leiomyoma.
Li
Jian-Rong
JR
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. JtonhLiem@sina.com
Wu
Lan-Sheng
LS
Zhang
Guang-Ping
GP
D031328:Ajuga / Q000737:chemistry; D000818:Animals; D017252:CD3 Complex / Q000097:blood; D015704:CD4 Antigens / Q000097:blood; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000097:blood; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D007889:Leiomyoma / Q000097:blood / Q000276:immunology* / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000097:blood; D013607:Tablets; D014594:Uterine Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology
D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D004365:Drugs, Chinese Herbal; D011960:Receptors, Estrogen; D013607:Tablets; D004958:Estradiol