[Side effects of COX-2 selective inhibitors. Critic related with its administration in patients with rheumatoid arthritis and osteoarthritis].
At the end of 2000 the new age of AINEs was introduced, specially the selective inhibitors of the COX-2, whose main function is to block the production of the prostaglandins and the acute tissue inflammation. These inhibitors have analgesic, antithermal and antiinflammatory effects similar to traditional AINEs; they are prescribed specifically to diminish pain and inflammation in patients with rheumatoid arthritis and osteoarthritis. After them introduction, it was reported that they can produce cardiovascular effects, mainly infarcts. This revision exposes the adverse effects that selective inhibitors of the COX-2 produce when elevated doses are administered, during prolonged time, in patients with rheumatoid arthritis and osteoarthritis; in addition, it comments present recommendations for them prescription.
Carrillo Gutiérrez
Ofmara Y
OY
Divisi6ón de Estudios de Postgrado de la Facultad de Ciencias Médicas y Biológicas, Dr. Ignacio Chávez, de la Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México.
Pérez Sánchez
Adriana G
AG
Medina Serriteño
Nicolás
N
Rodríguez Orozco
Alain R
AR
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects*; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy*; D011159:Population Surveillance
D052246:Cyclooxygenase 2 Inhibitors