Genetic and environmental influences on obsessive-compulsive disorder.
It is important to understand how genetic and environmental factors interact in the development of obsessive-compulsive disorder (OCD) in order to provide a cohesive model of the underlying pathogenic mechanisms. In this article, we provide an overview of the current knowledge of possible genetic and environmental contributions to the development of OCD. We consider the significant challenges for identifying risk factors for OCD as well as promising avenues for overcoming these obstacles in future research. In particular, we discuss the value of focusing on certain phenotypes, applying a dimensional approach, and investigating possible endophenotypes. We also describe innovative study designs that may be used in future research to explore the interaction between genetic vulnerability and environmental risk factors for OCD.
Grisham
Jessica R
JR
School of Psychology, University of New South Wales, Sydney, NSW, Australia. jgrisham@psy.unsw.edu.au
Anderson
Tracy M
TM
Sachdev
Perminder S
PS
D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000145:classification / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D010641:Phenotype; D012737:Sex Factors