[Studies on preparation of sinomenine hydrochloride-loaded bovine serum albumin microspheres].
OBJECTIVE
To prepare Sinomenine hydrochloride-loaded bovine serum albumin microspheres (SM-BSA-MS).


METHODS
SM-BSA-MS was prepared by spray drying technique. The morphology, drug-loading and release in vitro of SM-BSA-MS was studied.


RESULTS
The diameters of SM-BSA-MS were in the range of 1-3 m. The drug loading of microspheres, formulated with different drug/albumin ratios as 1, 2, 1:1, 2:1, were 31.6%, 47.7% and 67.9% , respectively. And the drug entrapment efficiencies of different drug/albumin ratios were higher than 94%. The results of in vitro release experiments showed that the drug loaded microspheres have the properties of sustained-release compared with the Sinomenine hydrochloride injection. Different release characteristics could be obtained by adjusting the prescription composition and the thermal denaturation condition.


CONCLUSIONS
Spray drying technique is a simple and feasible method for preparing SM-BSA-MS. The drug loaded microspheres had high drug-loading and sustained-release effect.
Zou
Ling-Yan
LY
Pharmaceutical Division, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China.
Feng
Jian-Fang
JF
Chen
Man-Cang
MC
D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D008863:Microspheres; D009019:Morphinans / Q000737:chemistry*; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D032841:Sinomenium / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009019:Morphinans; D012710:Serum Albumin, Bovine; C009271:sinomenine