title: 14-3-3 proteins regulate the potassium channel KAT1 by dual modes.
abstract: KAT1 is a cloned plant potassium channel belonging to the superfamily of Shaker-like Kv channels. Previous studies have shown that 14-3-3 proteins significantly increase KAT1 current by modifying the channel open probability. Employing a 14-3-3 scavenger construct to lower the long-term availability of endogenous 14-3-3 proteins, we found that 14-3-3 proteins not only control the voltage dependency of the channel but also the number of channels in the plasma membrane.
authors.affiliation: Dipartimento di Biologia and IBF-CNR, Università degli Studi di Milano, Milano, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Sottocornola
authors.forename: S
authors.initials: S
authors.lastname: Gazzarrini
authors.forename: C
authors.initials: C
authors.lastname: Olivari
authors.forename: G
authors.initials: G
authors.lastname: Romani
authors.forename: P
authors.initials: P
authors.lastname: Valbuzzi
authors.forename: G
authors.initials: G
authors.lastname: Thiel
authors.forename: A
authors.initials: A
authors.lastname: Moroni
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004594:Electrophysiology; D005260:Female; D015640:Ion Channel Gating / Q000235:genetics / Q000502:physiology*; D008564:Membrane Potentials; D009865:Oocytes / Q000378:metabolism / Q000502:physiology; D010940:Plant Proteins / Q000235:genetics / Q000502:physiology; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D048948:14-3-3 Proteins; D010940:Plant Proteins; D024661:Potassium Channels, Inwardly Rectifying