[Heart defects and other anomalies in fetuses conceived by assisted reproduction techniques].
OBJECTIVE
The aim of the work was to evaluate the frequency of occurrence of structural, chromosome defects and developmental disorders in fetuses conceived with the help of different assisted reproduction techniques.


METHODS
The research group consisted of 30 patients, aged from 25 to 37, subjected to various techniques of assisted reproduction from 2003 to 2006, who reported for consultation in the referral centre. 13 (43%) of the patients underwent the IVF procedure, 12 (40%) the ICSI procedure, 5 patients underwent interuterine insemination. Ultrasonographic examination with the evaluation of the fetal heart was conducted on average in the 22nd week of gestation.


RESULTS
Multiple pregnancies constituted 14 (47%) of the examined pregnancies. In total, fetal anomalies were diagnosed in 3 fetuses (6%). Cardiovascular anomalies occurred in 2 fetuses (atrioventricular septal defect--AVSD and ventricular septal defect--VSD), each with diagnosed trisomy of chromosome pairs 21 and 18 respectively. In one case an anomaly within the urinary system was diagnosed.


CONCLUSIONS
Multiple pregnancies constituted nearly half of the researched group. Structural defects were diagnosed in 3 (6%) fetuses, which slightly exceeds population risk. A higher anomaly percentage occurred in fetuses from twin pregnancies and in the group after ICSI. In the study the risk is related to the selected group of patient undergoing fetal echocardiography exam. To estimate the risk in the ART group precisely, all pregnancies conceived with implementation of ART should be examined. Multi-centre studies are our future goal.
Budziszewska
Patrycja
P
Oddział Kliniczny Ginekologii i Połoinictwa w Rudzie Slaskiej, Katedry Zdrowia Kobiety Wydziału Opieki Zdrowotnej Slaskiej Akademii Medycznej w Katowicach.
Włoch
Agata
A
Rozmus-Warcholińiska
Wioletta
W
Czuba
Bartosz
B
Kuka-Panasiuk
Dorota
D
Ilski
Aleksander
A
Sodowski
Marcin
M
Cnota
Wojciech
W
Ziomek
Maciej
M
Grettka
Krzysztop
K
Kiecka
Mariusz
M
Sodowski
Krzysztof
K
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D004314:Down Syndrome / Q000000981:diagnostic imaging; D005260:Female; D005307:Fertilization in Vitro; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging; D006801:Humans; D011044:Poland; D011247:Pregnancy; D011272:Pregnancy, Multiple; D012189:Retrospective Studies; D012307:Risk Factors; D016216:Ultrasonography, Prenatal