Exercise caution when taking ibuprofen.  High doses of ibuprofen have been associated with an increased risk of cardiovascular events.  How much is safe?
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000209:etiology*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen