Preoperative peripheral naïve / memory ratio and prognosis of nonsmall-cell lung cancer patients.
OBJECTIVE
This study focused on the relationship between preoperative peripheral blood CD4(+) naïve/memory ratio and prognosis following surgery for patients with nonsmall-cell lung cancer.


METHODS
After measuring CD3, CD4, CD8, CD45RA, CD45RO, CD25, and intracellular CTLA4 levels, CD4(+) naïve/memory ratios were determined for 13 controls and 38 patients.


RESULTS
Although we observed no significant difference in the ratios, the patients exhibited a wider range of values than the controls. Of the 38 patients, 24 subsequently underwent surgery and were divided into three groups based on their preoperative CD4(+) naïve/memory ratio: Group I: <0.3; Group II: 0.3-0.8; and Group III: >0.8. Survival times were then evaluated. Group II survival was significantly better than Groups I and III.


CONCLUSIONS
Our data suggest that the preoperative CD4(+) naïve/memory ratio may serve as a prognostic factor for nonsmall-cell lung cancer patients.
Hara
Masaki
M
Department of Cardiovascular, University of Miyazaki, Miyazaki, Japan.
Matsuzaki
Yasunori
Y
Shimizu
Tetsuya
T
Tomita
Masaki
M
Ayabe
Takanori
T
Enomoto
Yusuke
Y
Onitsuka
Toshio
T
D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000401:mortality; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
D017493:Leukocyte Common Antigens