title: Reagent-controlled domino synthesis of skeletally-diverse compound collections.
abstract: An efficient reagent-controlled methodology for generating highly substituted diverse scaffolds from a common substrate has been developed; thus, treatment of a common precursor with different desilylating reagents, such as ammonium fluoride, caesium fluoride and PPTS, triggers different domino reaction sequences, yielding highly substituted pyridines, phenols and benzopyrans, respectively; the substituent patterns of these scaffolds provide further opportunities for library development.
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. Herbert.Waldmann@mpi-dortmund.mpg.de
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
authors.forename: Marc
authors.initials: M
authors.lastname: Kühn
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Kamal
authors.initials: K
authors.lastname: Kumar
mesh_terms: D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D007202:Indicators and Reagents