Concise synthesis of 2-amino-4(3H)-quinazolinones from simple (Hetero)aromatic amines.
A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero)aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution.
Zeghida
Walid
W
Département Chimie Moléculaire, UMR 5250, Université Joseph Fourier, BP 53, 38041 Grenoble cedex 9, France.
Debray
Julien
J
Chierici
Sabine
S
Dumy
Pascal
P
Demeunynck
Martine
M
D000814:Aniline Compounds / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis*
D000814:Aniline Compounds; D052999:Quinazolinones