Antidepressant prescribing practices for the treatment of children and adolescents.
OBJECTIVE
This study evaluates pediatric antidepressant prescribing practices of Nebraska clinicians.


METHODS
Surveys were sent in July, 2005, to 1,521 prescribing clinicians throughout Nebraska to assess pediatric antidepressant use along with any practice changes following the U.S. Food and Drug Administration (FDA) "black box" warning issued in October, 2004.


RESULTS
Over half (n = 866) of the clinicians responded to the survey, of which 96.8% reported awareness of the FDA "black box" warning. Of the respondents, 76.9% (n = 666) were prescribing antidepressants to children and/or adolescents. Clinicians reported decreased prescribing frequency for both children (15.5%) and adolescents (36.6%), with 36% having increased referrals to specialists. While 31.9% reported seeing patients more frequently upon initiation of antidepressants, only 7.5% reported weekly visits for the first month of treatment, as recommended by the FDA. Over one fifth (21.9%) reported a caregiver or patient had refused antidepressant medication treatment due to the FDA's warning.


CONCLUSIONS
Clinicians in Nebraska report changes in clinical practice due to the issuance of the FDA "black box" warning, with a decrease in prescribing antidepressants to pediatric patients and an increase in referrals to specialists. Although awareness of the FDA's warning was evident among clinicians and patients, adherence to recommended guidelines was low.
Bhatia
Supriya K
SK
Psychopharmacology Research Center, 985581 University of Nebraska Medical Center, Omaha, NE 68198, USA.
Rezac
Amy J
AJ
Vitiello
Benedetto
B
Sitorius
Michael A
MA
Buehler
Bruce A
BA
Kratochvil
Christopher J
CJ
D000293:Adolescent; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D011307:Drug Prescriptions; D004363:Drug Utilization; D006801:Humans; D010818:Practice Patterns, Physicians'; D014481:United States; D014486:United States Food and Drug Administration
D000928:Antidepressive Agents