Body composition and serum prostate-specific antigen: review and findings from Flint Men's Health Study.
Recent studies have suggested that obesity is associated with lower serum prostate-specific antigen levels, perhaps influencing the recommendation for prostate biopsy and potentially explaining part of the observed poorer prognosis among obese men. African-American men have the greatest rates of prostate cancer and are more likely to die of the disease, making early detection a priority in this group. We present findings from the Flint Men's Health Study, a study of African-American men, that are consistent with most studies suggesting that overweight men have prostate-specific antigen levels that are 0.15 to 0.30 ng/mL lower than those who are not overweight. We have coupled our results with a systematic review of publications in this area.
Beebe-Dimmer
Jennifer L
JL
Karmanos Cancer Institute, Wayne State School of Medicine, Detroit, Michigan 48201, USA. dimmerj@karmanos.org
Faerber
Gary J
GJ
Morgenstern
Hal
H
Werny
David
D
Wojno
Kirk
K
Halstead-Nussloch
Bronwen
B
Cooney
Kathleen A
KA
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D001823:Body Composition; D001837:Body Weights and Measures; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000150:complications / Q000208:ethnology*
D017430:Prostate-Specific Antigen