Association of the asporin D14 allele with lumbar-disc degeneration in Asians.
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
Song
You-Qiang
YQ
Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China.
Cheung
Kenneth M C
KM
Ho
Daniel W H
DW
Poon
Sandy C S
SC
Chiba
Kazuhiro
K
Kawaguchi
Yoshiharu
Y
Hirose
Yuichiro
Y
Alini
Mauro
M
Grad
Sibylle
S
Yee
Anita F Y
AF
Leong
John C Y
JC
Luk
Keith D K
KD
Yip
Shea-Ping
SP
Karppinen
Jaro
J
Cheah
Kathryn S E
KS
Sham
Pak
P
Ikegawa
Shiro
S
Chan
Danny
D
D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001224:Aspartic Acid / Q000737:chemistry / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007403:Intervertebral Disc; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics; D010007:Osteochondritis / Q000235:genetics*; D011110:Polymorphism, Genetic; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics
C439889:ASPN protein, human; D016326:Extracellular Matrix Proteins; D001224:Aspartic Acid