title: A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy.
abstract: OBJECTIVE
  To observe the dose-response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy.
  
  
  METHODS
  One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and chi (2) test.
  
  
  RESULTS
  The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated.
  
  
  CONCLUSIONS
  The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.
authors.affiliation: Department of Pediatrics, Beijing TianTan Hospital, Beijing 100050, China. yajienet@yahoo.com.cn
authors.forename: Yajie
authors.initials: Y
authors.lastname: Wang
authors.forename: Baoqin
authors.initials: B
authors.lastname: Gao
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D002547:Cerebral Palsy / Q000150:complications*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000379:methods; D008297:Male; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology*; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D012720:Severity of Illness Index
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A