title: Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
abstract: Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Timmons
authors.forename: Mark
authors.initials: M
authors.lastname: Seierstad
authors.forename: Rich
authors.initials: R
authors.lastname: Apodaca
authors.forename: Matt
authors.initials: M
authors.lastname: Epperson
authors.forename: Dan
authors.initials: D
authors.lastname: Pippel
authors.forename: Sean
authors.initials: S
authors.lastname: Brown
authors.forename: Leon
authors.initials: L
authors.lastname: Chang
authors.forename: Brian
authors.initials: B
authors.lastname: Scott
authors.forename: Michael
authors.initials: M
authors.lastname: Webb
authors.forename: Sandra R
authors.initials: SR
authors.lastname: Chaplan
authors.forename: J Guy
authors.initials: JG
authors.lastname: Breitenbucher
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D006801:Humans; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy* / Q000201:enzymology*; D010147:Pain Measurement / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D013127:Spinal Nerves / Q000187:drug effects* / Q000293:injuries; D013329:Structure-Activity Relationship; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D010080:Oxazoles; D011725:Pyridines; D000099252:Fatty Acid Amide Hydrolases; C495479:1-oxo-1-(5-(2-pyridyl)-2-yl)-7-phenylheptane