title: Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance.
abstract: Cancer patients who receive chemotherapy often experience intrinsic or acquired resistance to a broad spectrum of chemotherapeutic agents. The phenomenon, termed multidrug resistance (MDR), is often associated with the over-expression of P-glycoprotein, a transmembrane protein pump, which can enhance efflux of a various chemicals structurally unrelated at the expense of ATP depletion, resulting in decrease of the intracellular cytotoxic drug accumulation. The MDR has been a big threaten to the human health and the war fight for it continues. Although several other mechanisms for MDR are elucidated in recent years, considerable efforts attempting to inverse MDR are involved in exploring P-glycoprotein modulators and suppressing P-glycoprotein expression. In this review, we will report on the recent advances in various strategies for overcoming or circumventing MDR mediated by P-glycoprotein.
authors.affiliation: Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong Province, PR China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Yuan
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Jifeng
authors.initials: J
authors.lastname: Wu
authors.forename: Jinpei
authors.initials: J
authors.lastname: Li
authors.forename: Xianjun
authors.initials: X
authors.lastname: Qu
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1