Checkpoint control: the journey continues.
Mad2 and p31(comet) are components of the spindle assembly checkpoint which controls the fidelity of chromosome segregation. Two recent structural studies reveal new insight into how these proteins achieve this difficult task.
Peters
Jan-Michael
JM
Research Institute of Molecular Pathology , Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. peters@imp.univie.ac.at
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D064246:Mad2 Proteins; D015394:Molecular Structure; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D008941:Spindle Apparatus / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; C577697:MAD2L1 protein, human; C470309:MAD2L1BP protein, human; D064246:Mad2 Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D012097:Repressor Proteins