Comparative study of conventional colonoscopy and pan-colonic narrow-band imaging system in the detection of neoplastic colonic polyps: a randomized, controlled trial.
BACKGROUND
Detection and removal of adenomas by colonoscopy is an important means for preventing cancer; however, small adenomas may be missed during colonoscopy. The narrow-band imaging (NBI) system clearly enhances the microvasculature in neoplastic lesions, making it appear as a dark complex. Therefore, the NBI system may improve the detection of colonic neoplasias. However, no randomized, controlled trials have evaluated the efficacy of a pan-colonic NBI system in adenoma detection. We conducted a randomized, controlled trial to determine the efficacy of the pancolonic NBI system in adenoma detection.


METHODS
Two hundred forty-three patients were randomized, 121 to conventional colonoscopy and 122 to pan-colonic NBI system. Demographics, indication for colonoscopy, and quality of preparation were similar between groups.


RESULTS
Extubation time was not significantly different between the conventional colonoscopy and pan-colonic NBI system. The proportions of patients with at least one adenoma and those with multiple adenomas were not significantly different between groups. However, the pan-colonic NBI system significantly increased the total number of adenomas detected (P < 0.05) and the number of diminutive (<5 mm) adenomas detected (P < 0.05). The pan-colonic NBI system allowed detection of more diminutive adenomas in the distal colon than did conventional colonoscopy (P < 0.01), and more patients in the NBI group had at least one diminutive adenoma than in the control group (P < 0.05).


CONCLUSIONS
The pan-colonic NBI system improves the total number of adenomas detected, including significantly more diminutive adenomas, without prolongation of extubation time. These results indicate that routine use of the NBI system for surveillance of diminutive adenomas may be recommended.
Inoue
Takuya
T
Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, 569-8686, Japan.
Murano
Mitsuyuki
M
Murano
Naoko
N
Kuramoto
Takanori
T
Kawakami
Ken
K
Abe
Yosuke
Y
Morita
Eijiro
E
Toshina
Ken
K
Hoshiro
Hideo
H
Egashira
Yutaro
Y
Umegaki
Eiji
E
Higuchi
Kazuhide
K
D001706:Biopsy; D003111:Colonic Polyps / Q000473:pathology*; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D014741:Video Recording / Q000295:instrumentation