title: Importance of iron and iron metabolism in nonalcoholic fatty liver disease.
abstract: Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.
authors.affiliation: Subdirección de Investigación Clínica, Instituto Nacional de Perinatologia, Mexico City, Mexico.
authors.forename: Hector
authors.initials: H
authors.lastname: Baptista-Gonzalez
authors.forename: Norberto C
authors.initials: NC
authors.lastname: Chavez-Tapia
authors.forename: Daniel
authors.initials: D
authors.lastname: Zamora-Valdés
authors.forename: Misael
authors.initials: M
authors.lastname: Uribe
authors.forename: Nahum
authors.initials: N
authors.lastname: Mendez-Sanchez
mesh_terms: D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000150:complications / Q000378:metabolism
chemical_list: D007501:Iron