title: Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans.
abstract: Hesperidin (Hsp) is an abundant flavonoid in citrus fruits, and the oral administration of Hsp has been recently reported to suppress collagen-induced arthritis in mice. Therefore, we sought to determine whether alpha-glucosylhesperidin (Hsp-G), which is an Hsp derivative with enhanced water-solubility, is effective on treating arthritis in both mice and humans. Hsp-G was orally administered to mice with collagen-induced arthritis, and its effects were evaluated clinically and histologically. Oral administration of Hsp-G improved collagen-induced arthritis when administered before the onset of arthritis as well as when administered after its onset. A decrease in tumor necrosis factor-alpha production was found to cause this improvement. In the human study, 19 patients with rheumatoid arthritis (RA) were enrolled in a 12-week double-blind, placebo-controlled trial. Patients were administered beverages containing 3 g Hsp-G (n = 9) or placebo (n = 10) every morning for the duration of the 3-month trial. Additionally, patients received standard therapy from a physician every 4 weeks. As a result, 3 of 9 patients in the Hsp-G group improved, while only 1 of 10 patients in the placebo group improved; this was in accordance with the American College of Rheumatology criteria. The present study revealed that the food material Hsp-G was effective when administered with standard anti-rheumatoid therapy in ameliorating RA in mice and humans without any adverse effects and may improve the quality of life for patients with RA as a complementary/alternative medicine.
authors.affiliation: Health Science Laboratory, Ezaki Glico Co., Ltd., Osaka, Japan. kometani-takashi@glico.co.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kometani
authors.forename: Takaaki
authors.initials: T
authors.lastname: Fukuda
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Kakuma
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: Wataru
authors.initials: W
authors.lastname: Tamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kumazawa
authors.forename: Kensei
authors.initials: K
authors.lastname: Nagata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018501:Antirheumatic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D002957:Citrus / Q000737:chemistry; D004311:Double-Blind Method; D005260:Female; D005502:Food; D005960:Glucosides / Q000737:chemistry / Q000627:therapeutic use*; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008875:Middle Aged; D010919:Placebos; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D005960:Glucosides; D010919:Placebos; C487382:glucosyl hesperidin; D006569:Hesperidin