Percutaneous pulmonary valve-in-valve implantation: a successful treatment concept for early device failure.
OBJECTIVE
Percutaneous pulmonary valve implantation (PPVI) is now an accepted treatment strategy for right ventricular (RV) outflow tract (RVOT) dysfunction in many European Heart Centres. We analysed the efficacy of repeat PPVI as a treatment modality for early device failure.


RESULTS
Twenty patients underwent repeat PPVI for RVOT obstruction because of early device failure ('Hammock effect', 'Hammock-like effect', stent fracture, residual stenosis). Repeat PPVI was feasible in all patients with no procedural complications. Following implantation of a second device, catheter-measured RVOT gradient and RV systolic pressure fell significantly (RVOT gradient: 46.1 +/- 3.9 to 18.1 +/- 2.4 mmHg, P < 0.001; RVSP: 70.9 +/- 4.8 to 46.1 +/- 2.6 mmHg, P < 0.001), in all but one patient (15 years, male, common arterial trunk, 11.5 mm homograft). During follow-up, four of 20 required re-intervention [third PPVI for stent fracture (n = 2), device explantation: external compression by the sternum (n = 1), endocarditis (n = 1)], and one of the 20 is awaiting surgical management. In the remainder, second PPVI resulted in a sustained improvement in haemodynamics with a mean follow-up of 10.9 +/- 3.0 months. In this series, the probability of freedom from re-intervention at 2 years was higher after second PPVI when compared with the index procedure (89.4 vs. 20.0%, P < 0.001).


CONCLUSIONS
Repeat PPVI is an effective treatment for early device failure in defined conditions and leads to improved freedom from re-intervention.
Nordmeyer
Johannes
J
Cardiothoracic Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Coats
Louise
L
Lurz
Philipp
P
Lee
Twin-Yen
TY
Derrick
Graham
G
Rees
Philipp
P
Cullen
Seamus
S
Taylor
Andrew M
AM
Khambadkone
Sachin
S
Bonhoeffer
Philipp
P
D000293:Adolescent; D000328:Adult; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000601:surgery; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D011475:Prosthesis Failure; D011664:Pulmonary Valve; D011665:Pulmonary Valve Insufficiency / Q000628:therapy*; D055502:Secondary Prevention; D016896:Treatment Outcome; D014694:Ventricular Outflow Obstruction / Q000628:therapy*