Atherosclerotic cardiovascular disease in systemic lupus erythematosus: the Beer Sheva experience.
Atherosclerotic disease is common in systemic lupus erythematosus and is the result of multiple pathogenic mechanisms that include traditional risk factors as well as SLE-related factors. Endothelial dysfunction and arterial stiffness contribute significantly to the atherogenic process. Dobutamine stress echocardiogram has not been shown to detect subclinical coronary artery disease; however, the high percentage of left ventricular outflow gradient requires further evaluation and follows-up studies.
Abu-Shakra
Mahmoud
M
Rheumatic Diseases Unit and Lupus Clinic, Soroka Medical Center, Beer Sheva, Israel. mahmoud@bgu.ac.il
Codish
Shlomi
S
Zeller
Lior
L
Wolak
Talya
T
Sukenik
Shaul
S
D050197:Atherosclerosis / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000175:diagnosis; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007557:Israel; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008403:Mass Screening / Q000379:methods; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology