title: Detection of mechanical ventricular asynchrony by high temporal resolution cine MRI.
abstract: The purpose was to assess the feasibility of high temporal resolution cine MRI (HTRC-MRI) to detect and to quantify mechanical ventricular asynchrony in patients with left bundle branch block (LBBB). Inter- and intraventricular delays were quantified by HTRC-MRI in 32 patients with (n=17) and without (n=15) LBBB. In patients with LBBB, delays by HTRC-MRI were correlated with echocardiographic parameters using pulsed wave Doppler echocardiography (PW-Echo) and tissue Doppler imaging (TDI-Echo). The interventricular delay by HTRC-MRI was 110+/-50 ms in patients with and -1+/-18 ms in patients without LBBB (P<0.0001). The intraventricular delay was 336+/-86 ms in patients with compared to 40+/-49 ms in patients without LBBB (P<0.0001). A strong correlation (r=0.78, P=0.0002) and good agreement (mean difference: 39+/-36 ms) was found for the interventricular delay between HTRC-MRI and PW-Echo. A good correlation (r=0.66, P=0.0042), but a large discrepancy (mean difference: 257+/-64 ms) was found for the intraventricular delay between HTRC-MRI and TDI-Echo. Detection and quantification of mechanical ventricular asynchrony using HTRC-MRI is feasible. However, further comparison with other imaging modalities is required.
authors.affiliation: Center for Cardiology and Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. kaiml@web.de
authors.forename: Kai
authors.initials: K
authors.lastname: Muellerleile
authors.forename: Alexander
authors.initials: A
authors.lastname: Stork
authors.forename: Martin
authors.initials: M
authors.lastname: Bansmann
authors.forename: Achim
authors.initials: A
authors.lastname: Barmeyer
authors.forename: Alexander
authors.initials: A
authors.lastname: Dinkelacker
authors.forename: Loant
authors.initials: L
authors.lastname: Baholli
authors.forename: Joachim
authors.initials: J
authors.lastname: Graessner
authors.forename: Ralf
authors.initials: R
authors.lastname: Koester
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: Gunnar
authors.initials: G
authors.lastname: Lund
mesh_terms: D002037:Bundle-Branch Block / Q000503:physiopathology*; D016009:Chi-Square Distribution; D018619:Echocardiography, Doppler, Pulsed; D004562:Electrocardiography; D005240:Feasibility Studies; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged