title: Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique.
abstract: Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs.51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.
authors.affiliation: Departamento de Microbiologia, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors.forename: Marco
authors.initials: M
authors.lastname: Tovar
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Siedner
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Carlos
authors.initials: C
authors.lastname: Santillan
authors.forename: Luz
authors.initials: L
authors.lastname: Caviedes
authors.forename: Teresa
authors.initials: T
authors.lastname: Valencia
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Jave
authors.forename: A Rod
authors.initials: AR
authors.lastname: Escombe
authors.forename: David A J
authors.initials: DA
authors.lastname: Moore
authors.forename: Carlton A
authors.initials: CA
authors.lastname: Evans
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology; D003470:Culture Media; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D012680:Sensitivity and Specificity; D013997:Time Factors; D014396:Tuberculosis, Pleural / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D003470:Culture Media