A survivor hits the breaks.
Bcl2 is the founding member of a family of proteins that regulates apoptosis by controlling mitochondrial outer membrane integrity. In this issue of Molecular Cell, Wang et al. (2008) propose another function for Bcl2: the inhibition of DNA repair by nonhomologous end-joining.
Green
Douglas R
DR
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. douglas.green@stjude.org
McKinnon
Peter J
PJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D008958:Models, Molecular; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000378:metabolism*
D019253:Proto-Oncogene Proteins c-bcl-2