title: Metaanalysis of filler materials in periapical surgery.
abstract: OBJECTIVE
  To evaluate the success and failure, apical sealing and biocompatibility of silver amalgam, IRM, SuperEBA and MTA as retrograde filler materials.
  
  
  METHODS
  A metaanalysis is made of filler materials in periapical surgery, evaluating a total of 30 articles published in recent years.
  
  
  RESULTS
  Percentage success with silver amalgam was 76.5% and slightly inferior to that afforded by IRM. Performance in turn increased considerably when the materials used were SuperEBA or MTA. As regards marginal leakage, MTA with a mean leakage time of 65.5 days afforded the best results, followed by SuperEBA, IRM and silver amalgam. MTA was the most biocompatible of the materials studied, with practically no inflammatory response, while inflammation proved mild or moderate with SuperEBA, mild with IRM, and moderate to severe in the case of silver amalgam. Tissue regeneration was only observed with MTA, in the same way as cement appositioning. Bone neoformation was observed with all four filler materials.
  
  
  CONCLUSIONS
  MTA appears to be an ideal material, though the results obtained require confirmation by in vivo studies.
authors.affiliation: Oral Surgery, Implantology and Periodontics of Mississippi University Institution, USA. aferya_1980@hotmail.com.
authors.forename: Angela
authors.initials: A
authors.lastname: Fernández-Yáñez Sánchez
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Leco-Berrocal
authors.forename: José M
authors.initials: JM
authors.lastname: Martínez-González
mesh_terms: D017607:Aluminum Compounds; D017610:Calcium Compounds; D003723:Dental Amalgam; D017220:Dentin-Bonding Agents; D004338:Drug Combinations; D006801:Humans; D008768:Methylmethacrylates; D010087:Oxides; D010483:Periapical Diseases / Q000601:surgery*; D012387:Root Canal Filling Materials; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D017220:Dentin-Bonding Agents; D004338:Drug Combinations; D008768:Methylmethacrylates; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement; C086631:mineral trioxide aggregate; C107243:silver mercury amalgam; C031667:IRM cement; D003723:Dental Amalgam; C084074:Super EBA