title: Effect of brain DHA levels on cytoskeleton expression.
abstract: Brain docosahexaenoic acid (DHA, 22:6n-3) levels are associated with learning memory performance, but it is not known the mechanism of DHA on enhancing memory effect. The aim of this study was to examine effect of brain DHA levels on cytoskeleton expression. Rats were fed a chow or sunflower oil-based n-3 fatty acid-deficient diet supplemented with or without fish oil starting from embryo and through postnatal day 140. The various DHA levels were from 5.0% to 15.6% of total fatty acids in hippocampus, 3.9% to 13.7% in visual cortex, and 5.3% to 14.4% in olfactory bulbs. The expression of the cytoskeleton markers tyrosine tubulin, acetylated tubulin, and beta-actin in the hippocampus, visual cortex and olfactory bulb was not affected by brain DHA levels.
authors.affiliation: Department of Physiology, National Taiwan University College of Medicine, No. 1, Jen-Ai Rd, 1 sec, Taipei, 100, Taiwan.
authors.forename: Ann-Che
authors.initials: AC
authors.lastname: Hasio
authors.forename: Jen-Jui
authors.initials: JJ
authors.lastname: Chen
authors.forename: Wan-Ling
authors.initials: WL
authors.lastname: Chung
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Su
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005395:Fish Oils; D015870:Gene Expression; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010938:Plant Oils; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000074242:Sunflower Oil; D014404:Tubulin / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D014404:Tubulin; D004281:Docosahexaenoic Acids