[Retrospective study of chemoradiotherapy based on cisplatin compared with radiotherapy alone for cervical cancer].
OBJECTIVE
To compare the treatment effects and side events between chemoradiotherapy and radiotherapy alone for patients with primary cervical cancer.


METHODS
Totally 197 patients with primary cervical cancer in our hospital from 2000 to 2006 were studied. They were divided into two groups: radiotherapy alone (RT) or cisplatin-based chemoradiotherapy (CRT). Group of RT included 100 patients who received external irradiation by (60)Co and intracavitary irradiation by (192)Ir. Group of CRT included 97 patients who received cisplatin-based chemoradiotherapy. The RT regimen was the same as group RT.


RESULTS
The local control (CR + PR) in two groups had no statistic difference (P = 0.500). The total 5 year survival rate in the two groups were 82% and 79%, with no significant difference (P = 0.177); however, there was a significant difference for stage III squamous cell carcinoma of the cervix, the 5 year survival rate being 56% and 84%, respectively (P < 0.01). The common side effect was hematological toxicity in some patients, which was more serious in CRT group than in RT group. Grade 3 hematological toxicity were 3% and 14% (P < 0.01), although the long-term complications in two groups were not different (P = 0.496).


CONCLUSIONS
Chemoradiotherapy based on cisplatin may be effective for stage III squamous cell carcinoma of the cervix.
Han
Chao
C
Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital University of Medical Sciences, Beijing 100006, China.
Kong
Wei-min
WM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003556:Cystitis / Q000209:etiology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D013921:Thrombocytopenia / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*
D002945:Cisplatin; D005472:Fluorouracil