Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan.
Pestafolide A ( 1), a new reduced spiro azaphilone derivative, and pestaphthalides A ( 2) and B ( 3), two new isobenzofuranones, have been isolated form solid cultures of an isolate of Pestalotiopsis foedan. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative configuration of 1- 3 was assigned by analysis of (1)H NMR J-values and NOESY data, and the absolute configuration was determined by application of the CD excitation chirality and modified Mosher method. Compounds 1- 3 showed modest antifungal activity.
Ding
Gang
G
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, China.
Liu
Shuchun
S
Guo
Liangdong
L
Zhou
Yuguang
Y
Che
Yongsheng
Y
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000935:Antifungal Agents; D001572:Benzofurans; D001578:Benzopyrans; D010860:Pigments, Biological; D013141:Spiro Compounds; C494154:azaphilone; C529470:pestafolide A