[Antimicrobial therapy associated with preterm birth].
The effect of 51 antimicrobial drugs was evaluated for the reduction of preterm birth.


METHODS
Newborn infants without birth defects were selected from the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996, for the study. Medically recorded gestational age and the proportion of preterm birth were the primary outcomes of the study and newborn infants born to mothers with or without a given antimicrobial drug were compared.


RESULTS
The use of 51 antimicrobial drugs in the mothers of 38 151 newborn infants including at least ten pregnant women was evaluated. Only two: ampicillin and clotrimazole showed an obvious preterm birth preventive effect, mainly after the use during the first trimester of pregnancy.


CONCLUSIONS
Our findings suggest that ampicillin and particularly clotrimazole may be effective for the reduction of preterm birth associated with infectious diseases of pregnant women.
Kazy
Zoltán
Z
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Szülészeti és Nogyógyászati Klinika, Budapest. kazydoki@gmai.com
Puhó
Erzsébet
E
Czeizel
Endre
E
D000328:Adult; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D016022:Case-Control Studies; D003022:Clotrimazole / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D006801:Humans; D006814:Hungary; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D047928:Premature Birth / Q000382:microbiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000667:Ampicillin; D003022:Clotrimazole