title: Botox for the brain: enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories.
abstract: It has been suggested that the recent rapid developments in the fields of neuroscience and psychopharmacology have increased the possibilities for pharmacological enhancement of mental functioning. Here, evidence is reviewed which shows that drugs acting on a variety of neurotransmitter systems can indeed enhance cognition, and to a lesser extent mood and pro-social behavior. Moreover, it seems possible to interfere with the (re)consolidation of traumatic memories. There are, however, a number of caveats: first, as cognition-enhancing drugs can simultaneously exert both linear and quadratic (U-shaped) effects, doses most effective in facilitating one behavior could at the same time exert null or even detrimental effects on other cognitive domains. Second, individuals with a 'low memory span' might benefit from cognition-enhancing drugs, whereas 'high span subjects' are 'overdosed'. And finally, evidence suggests that a number of trade-offs could occur. For example, increases of cognitive stability might come at the cost of a decreased capacity to flexibly alter behavior. A short overview of ethical issues raised by the use of cognition and mood enhancing drugs demonstrates the tremendous variety in views and opinions regarding the subject.
authors.affiliation: Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, the Netherlands. dejongh@fsw.eur.nl
authors.forename: Reinoud
authors.initials: R
authors.lastname: de Jongh
authors.forename: Ineke
authors.initials: I
authors.lastname: Bolt
authors.forename: Maartje
authors.initials: M
authors.lastname: Schermer
authors.forename: Berend
authors.initials: B
authors.lastname: Olivier
mesh_terms: D000339:Affect / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008568:Memory / Q000187:drug effects*; D012919:Social Behavior
chemical_list: D000697:Central Nervous System Stimulants