Severe hemolytic disease of the newborn from anti-e.
Maternal antibody-mediated fetal red blood cell destruction secondary to non-D Rhesus (Rh) antibodies is a significant cause of hemolytic disease of the newborn (HDN). Here, we report a rare case of severe HDN associated with maternal antibody to Rh e. In addition to severe anemia, the infant developed thrombocytopenia, conjugated hyperbilirubinemia and cholelithiasis. Resolution of the infant's cholelithiasis occurred following treatment with ursodeoxycholic acid.
McAdams
R M
RM
Department of Neonatology, US Naval Hospital Okinawa and 18th Medical Group, Kadena Air Base, Kadena, Japan. ryan.mcadams@.med.navy.mil
Dotzler
S A
SA
Winter
L W
LW
Kerecman
J D
JD
D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002769:Cholelithiasis / Q000209:etiology; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal; D007231:Infant, Newborn; D010789:Phototherapy; D012203:Rh Isoimmunization / Q000276:immunology / Q000503:physiopathology*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D013921:Thrombocytopenia / Q000209:etiology; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D002756:Cholagogues and Choleretics; D012204:Rh-Hr Blood-Group System; D014580:Ursodeoxycholic Acid