LPS/TLR4 signal transduction pathway.
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.
Lu
Yong-Chen
YC
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1.
Yeh
Wen-Chen
WC
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1. Electronic address: wyeh38@gmail.com.
Ohashi
Pamela S
PS
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1; Department of Immunology, University of Toronto, Toronto, Ont., Canada M5S1A8. Electronic address: pohashi@uhnres.utoronto.ca.
D000818:Animals; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D015398:Signal Transduction / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000502:physiology*
D008070:Lipopolysaccharides; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4