Calcium alginate film used for guided bone regeneration in mandible defects in a rabbit model.
The objective of this research was to study a new bioabsorbable membrane material, calcium alginate film (CAF), used for guided tissue regeneration (GTR) or guided bone regeneration (GBRL). Circular bone defects of five mm diameter were created in the corners of the mandibles in 45 rabbits. The defects covered with calcium alginate film (CAF) served as the experimental sites, and collagen membrane (CM) or no membrane served as the control sites without considering left or right side, just with a mark on the ear of the same side. The healing condition was analyzed by histological studies and histometry analysis after one, two, four, six, and eight weeks. The histological evaluation showed that the bone regeneration pattern was centripetal in growth from the defect rim. The quantitative histometry analysis showed significantly more and faster newly generated bone in CAF defects than that in CM defects or in empty defects (p < 0.01) at two, four, six, and eight weeks postsurgically. Calcium alginate film was more effective for GTR and GBR than the collagen membrane.
He
Hong
H
Second Affiliated Hospital of Medical School, Zhejiang University, China. honghehh70@sina.com
Huang
Jianqi
J
Ping
Feiyun
F
Sun
Gang
G
Chen
Guanfu
G
D000464:Alginates / Q000627:therapeutic use*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use; D020723:Glucuronic Acid / Q000627:therapeutic use; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006603:Hexuronic Acids / Q000627:therapeutic use; D008297:Male; D008334:Mandible / Q000601:surgery*; D011817:Rabbits
D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D003094:Collagen