Relation of corrected thrombolysis in myocardial infarction frame count and ST-segment resolution to myocardial tissue perfusion after acute myocardial infarction.
OBJECTIVE
To evaluate myocardial tissue perfusion by corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) and ST-segment resolution after successful percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).


BACKGROUND
Early and sustained potency of infarct-related artery (IRA) has become the main goal of reperfusion therapy in patients with AMI. However, myocardial tissue perfusion may remain impaired even after the achievement of TIMI grade 3 flow of the epicardial artery without residual stenosis.


METHODS
CTFC was measured after successful PCI in 63 patients with first AMI. The extent of ST-segment resolution was recorded 1 hr after reperfusion therapy. The wall motion score index (WMSI) was assessed before and 1 month after PCI. Then we studied the correlation between CTFC, ST-segment resolution, and WMSI.


RESULTS
According to CTFC, the patients with TIMI grade 3 flow after PCI were divided into two groups: CTFC fast group and CTFC slow group. CTFC fast group had higher percentage of complete ST resolution (54.1% vs. 25.0%, P < 0.05) and lower percentage of no ST resolution (2.6% vs. 29.2%, P < 0.05). Improvement of WMSI in the CTFC fast group was significantly greater than that of the CTFC slow group (1.30 +/- 0.41 vs. 0.64 +/- 0.30, P < 0.05). CTFC had a significant negative correlation with the change in WMSI (r = -0.75, P < 0.01).


CONCLUSIONS
Combined with ST-segment resolution, CTFC could predict risk for patients with successful reperfusion therapy after AMI and provide evidence for additional adjunctive treatment.
Li
Chun-Mei
CM
Department of Cardiology, Shandong Provincial Hospital of Shandong University, Jinan 250021, China.
Zhang
Xing-Hua
XH
Ma
Xiao-Jing
XJ
Zhu
Xing-Lei
XL
D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D006328:Cardiac Catheterization; D015331:Cohort Studies; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D004638:Emergency Treatment; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D009204:Myocardial Revascularization / Q000379:methods; D011336:Probability; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents; D016019:Survival Analysis; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency / Q000502:physiology*