title: Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.
abstract: OBJECTIVE
  To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence.
  
  
  METHODS
  Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months).
  
  
  RESULTS
  Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence (P<0.05). The Cox multivariate analysis indicated the nucleophosmin/B23 expression as an independent indicator for tumor recurrence (P=0.009).
  
  
  CONCLUSIONS
  The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence.
authors.affiliation: Chang Gung Bioinformatics Center, Department of Urology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kwei-Shan, Taiwan, China.
authors.forename: Ke-hung
authors.initials: KH
authors.lastname: Tsui
authors.forename: Horng-heng
authors.initials: HH
authors.lastname: Juang
authors.forename: Tsong-hai
authors.initials: TH
authors.lastname: Lee
authors.forename: Phei-lang
authors.initials: PL
authors.lastname: Chang
authors.forename: Chien-lun
authors.initials: CL
authors.lastname: Chen
authors.forename: Benjamin Yat-ming
authors.initials: BY
authors.lastname: Yung
mesh_terms: D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology / Q000601:surgery; D015653:Cystectomy; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D000090243:Nucleophosmin; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D012044:Regression Analysis; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery
chemical_list: C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D012333:RNA, Messenger; D000090243:Nucleophosmin