[Network theory in autoimmunity].
The presence on periphery auto-reactive lymphocytes and antibodies, showing non-pathogen activity in norm and at many infections allows to enter concept the autoimmune state. Autoimmune state reflects that part of a functional condition of the immune system, which characterizes its activity in relation to autoantigens. The competence auto-reactive lymphocytes cells can not be explained in frameworks of mechanisms of formation natural tolerance, which assume auto-reactive lymphocytes exception or anergy. The new representation is necessary about, why the immune system in norm does not react on autoantigens and why loses ability to distinguish their and another. There are bases to believe, that the natural tolerance is formed as reaction of the immune system to autoantigens, which establishes the subsequent limiting control of auto-reactive lymphocytes. The natural tolerance is one of properties of the immune network.
Beduleva
L V
LV
Men'shikov
I V
IV
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D017634:Self Tolerance