title: Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients.
abstract: Mutations of the p53 gene represent the most common genetic alterations in human cancer. Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid. Polymorphisms at codon 72 of the p53 gene were determined using a PCR-RFLP-based method. We analysed the relationship of this polymorphism to patient survival in 121 non-small cell lung cancer (NSCLC) cases. Interestingly, the 72P homozygous NSCLC patients often presented high-grade tumours and had significantly poorer survival rates than patients with R72 homozygotes or heterozygotes. Our results may help clarify discrepancies in the literature concerning the prognostic role of p53 codon 72 variants.
authors.affiliation: Department of Surgery, University of Pisa, 56126 Pisa, Italy. l.boldrini@med.unipi.it
authors.forename: Laura
authors.initials: L
authors.lastname: Boldrini
authors.forename: Silvia
authors.initials: S
authors.lastname: Gisfredi
authors.forename: Silvia
authors.initials: S
authors.lastname: Ursino
authors.forename: Marco
authors.initials: M
authors.lastname: Lucchi
authors.forename: Giordana
authors.initials: G
authors.lastname: Greco
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mussi
authors.forename: Gabriella
authors.initials: G
authors.lastname: Fontanini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D003062:Codon; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D011392:Proline / Q000235:genetics*; D015996:Survival Rate
chemical_list: D003062:Codon; D001120:Arginine; D011392:Proline