Abdominal manifestations of neurofibromatosis.
The purpose of this review is to illustrate, with examples, the abdominal manifestations of neurofibromatosis type 1 (NF) on imaging, with emphasis on computed tomography. Mutations of the NF gene lead to abnormal tumor suppression. Consequently, NF is a complex disease, with patients having an increased prevalence of benign and malignant neoplasms throughout the body. We present cases of the most common abdominal presentations: neurofibroma, malignant peripheral nerve sheath tumor, pheochromocytoma, carcinoid, gastrointestinal stromal tumor, and seminoma.
Hartley
Nicola
N
Department of Radiology, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, United Kingdom. nicola.hartley@uhl-tr.nhs.uk
Rajesh
Arumugam
A
Verma
Ratan
R
Sinha
Rakesh
R
Sandrasegaran
Kumaresan
K
D000008:Abdominal Neoplasms / Q000175:diagnosis*; D004701:Endocrine Gland Neoplasms / Q000175:diagnosis*; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis*; D006801:Humans; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis*; D018358:Neuroendocrine Tumors / Q000175:diagnosis*; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis; D011860:Radiography, Abdominal / Q000379:methods; D018239:Seminoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography