Diffusion generated T1 and T2 contrast.
In MR images of porous organic samples (such as roots or wood) in water media, the sample is often surrounded by a bright ring, with a corresponding decreased T1 value in T1 maps. When the medium is removed, or contrast agents are added, the ring disappears, indicating that the signal does not originate in the outer layers of the sample, but from the medium itself. It can be shown that this "bright ring effect" is only observed when the medium experiences a reduction in T1 when permeating the sample. In order to investigate this effect, a computer model was used to simulate the diffusion of magnetisation between regions that exhibit different relaxation constants. Using this model, the origin of the signal increase was found to be an inflow effect, as diffusion transports relaxed magnetisation from the boundary regions of the sample into the surrounding medium. In the case of the "bright ring" around the plants described above, a mixing of short T1 values from within the sample and long T1 values within the medium occurs, yielding a "transition region" between the two values. There, a signal increase can be observed at T1 weighted images, compared to the signal from the medium beyond this transition region. The width of the transition region is on the order of magnitude of the diffusion displacement that is calculated from the T1 value as diffusion time. In addition to causing the bright ring around the plant samples, this diffusion effect also limits the resolution of the relaxation time maps. This effect is not limited to T1 relaxation but also applies to T2 relaxation. However, at high B0 field strengths such as those used in this study (11.7 T), a T2 effect is not usually observed due to the considerably shorter T2 times in plants (about 50 ms, compared to T1 times of higher than 1 s). Because the diffusion length during this T2 relaxation is short with respect to the resolution of the imaging experiments, no T2 ring effect is seen.
Kaufmann
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I
Department of Physics, EP5 (Biophysics), University of Würzburg, Würzburg, Germany. kaufmann@physik.uni-wuerzburg.de
Seiberlich
N
N
Haase
A
A
Jakob
P
P
D003198:Computer Simulation; D003287:Contrast Media; D003510:Cyclohexanes / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D019786:Gadolinium DTPA; D018514:Plant Structures; D003313:Zea mays
D003287:Contrast Media; D003510:Cyclohexanes; C506365:Cyclohexane; D019786:Gadolinium DTPA