Dermatitis herpetiformis in siblings.
Two Caucasian sisters, XZ and YZ, suffered from DH. However, the clinical course of their diseases was different; patient XZ, contrary to her sister YZ, suffered besides dermatitis herpetiformis (DH) also from coeliac disease (CD) and an autoimmune thyroid disease. The sisters were ordered to adhere to gluten-free diet and dapsone was prescribed, however, patient XZ developed a hypersensitivity to dapsone. The HLA typing disclosed that they were homozygous and that they shared HLA alleles DQB1*0201. Our results confirm the known association of DH to other autoimmune disorders and its well established association the HLA-DQB1*0201 allele. Although DH is generally not regarded as a familial disease our case report suggests its familial character (Fig. 3, Ref. 10). Full Text (Free, PDF) www.bmj.sk.
Chmurova
N
N
Department of Dermatovenerology, Faculty of Medicine, Comenius University, Mickiewiczova 13, SK-813 69 Bratislava 1, Slovakia. nada.chmuroav@centrum.sk
Parnicka
Z
Z
Svecova
D
D
Manova
A
A
Simaljakova
M
M
D000328:Adult; D002446:Celiac Disease / Q000150:complications / Q000235:genetics; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D006683:HLA-DQ Antigens / Q000097:blood; D059866:HLA-DQ beta-Chains; D006801:Humans; D013967:Thyroiditis, Autoimmune / Q000150:complications
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen