[Effect of Danxiongfang and its components on experimental liver injury models induced by CCl4 in mice].
OBJECTIVE
The study investigates the protective effect on liver of Danxionfang and its components.


METHODS
Mice are injected with CCl4 to establish liver injured model. ALT, AST, serum albumin, globulin in serum and SOD, MDA in liver and liver histological changes were measured to confirm the ability of protecting liver of Danxiongfang.


RESULTS
The results show Danxiongfang can inhibit obviously the abnormal increase of ALT, AST in serum and MDA in liver, enhance SOD activity in liver, total protein, albumin, globulin in serum, and decrease liver pathological changes, which suggests Danxiongfang can protect injured liver induced by CCl4.


CONCLUSIONS
Danxiongfang showed powerful protective effect against liver damage induced by CCl4.
Li
Xiao-Rong
XR
Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences Institute of Material Medical, Capital Medical University, Beijing 100069, China.
Wang
Li-Juan
LJ
Li
Yu-Hang
YH
Xu
Yan-Xia
YX
Chen
Yi
Y
Ruan
Jin-Xiu
JX
Xue
Ming
M
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D030004:Ligusticum / Q000737:chemistry; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase