Rat models of cardiac insulin resistance.
Cardiovascular disease is the leading cause of death in the industrialized world. Diabetes is a major risk factor for cardiovascular disease. Unchecked diabetes can also lead to renal failure, blindness, heart attack, stroke, and amputation. The focus of this chapter will be to review the different mechanisms of insulin resistance (IR)/type 2 diabetes and various animal models used to study cardiac changes during these conditions.
Ghosh
Sanjoy
S
Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, British Columbia, Canada.
Rodrigues
Brian
B
Ren
Jun
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005938:Glucocorticoids / Q000009:adverse effects; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D023421:Models, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005938:Glucocorticoids; D007328:Insulin