Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents.
The efficient synthesis of novel azetidin-2-ones 6 has been established. Thus, condensation of 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-amine 4 with various aromatic aldehydes afforded 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-N-[(substituted) phenylmethylidene]-1,3,4-thiadiazol-2-amine 5 which on cycloaddition with chloroacetyl chloride in the presence of triethylamine catalyst yielded 3-chloro-1-{5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-yl}-4-(substituted) phenylazetidin-2-one 6. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.
Ansari
K F
KF
Department of Chemistry, Harcourt Butler Technological Institute, Nawabganj, Kanpur 208004, Uttar Pradesh, India.
Lal
C
C
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001384:Azetidines / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000447:Aldehydes; D000588:Amines; D000890:Anti-Infective Agents; D001384:Azetidines