Polyadenylation in mammalian mitochondria: insights from recent studies.
Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3' termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.
Nagaike
Takashi
T
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Suzuki
Tsutomu
T
Ueda
Takuya
T
D000818:Animals; D018388:Codon, Terminator / Q000235:genetics / Q000378:metabolism*; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000201:enzymology* / Q000235:genetics; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D026723:Polyadenylation / Q000502:physiology*; D011062:Polynucleotide Adenylyltransferase / Q000235:genetics / Q000378:metabolism*
D018388:Codon, Terminator; D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins; D011062:Polynucleotide Adenylyltransferase