title: Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission: a Go/Nogo study.
abstract: Major depressive disorder (MDD) can be characterized by a wide-ranging profile of cognitive deficits including attention, memory, and executive functions which is possibly due to reduced volumes and a hypometabolism of the anterior cingulate cortex, orbitofrontal, and dorsolateral prefrontal cortex. We examined 21 patients with MDD in partial remission and 21 age-, sex-, and education matched healthy controls using event-related potentials (ERPs). Participants performed a hybrid flanker Go/Nogo task while multichannel EEG was recorded. Two ERP components were of interest which repeatedly have been linked to response inhibition: the Nogo-N2 and the Nogo-P3 which can be observed in Nogo trials of a Go/Nogo task. MDD patients showed a specifically reduced Nogo-P3 while the Nogo-N2 and the P3b in Go trials were unaffected. These results provide further evidence of impaired response monitoring and control processes in patients with MDD.
authors.affiliation: Department of Psychiatry, Christophsbad Göppingen, Germany. martin.ruchsow@christophsbad.de
authors.forename: Martin
authors.initials: M
authors.lastname: Ruchsow
authors.forename: Georg
authors.initials: G
authors.lastname: Groen
authors.forename: Markus
authors.initials: M
authors.lastname: Kiefer
authors.forename: Petra
authors.initials: P
authors.lastname: Beschoner
authors.forename: Leopold
authors.initials: L
authors.lastname: Hermle
authors.forename: Dietrich
authors.initials: D
authors.lastname: Ebert
authors.forename: Michael
authors.initials: M
authors.lastname: Falkenstein
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003657:Decision Making / Q000502:physiology*; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests