title: Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates.
abstract: A series of the copper (II) complexes 5a-d of estrogen-macrocyclic polyamine conjugates were synthesized and characterized. The interactions of complexes 5a-d with DNA were studied by fluorescence spectroscopy and gel electrophoresis under physiological conditions. The results indicate that the conjugated estrogens have increased the cleavage efficiency of Cu[cyclen](2+) while the conjugates display poor binding affinities. The functional groups of D-ring of estrogens may play a key role in deciding binding and cleavage extent of the complexes to DNA.
authors.affiliation: Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, No. 29, Wangjiang Road, Chengdu, Sichuan 610064, PR China.
authors.forename: Xin-Bin
authors.initials: XB
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Hong-Hui
authors.initials: HH
authors.lastname: Lin
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Zhou
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D004967:Estrogens; D047028:Macrocyclic Compounds; D011073:Polyamines; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; D003851:Deoxyribonucleases