Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population.
OBJECTIVE
To evaluate the association between genetic polymorphisms of CYP2E1 RsaI and GSTM1 and development of bladder cancer in a south-eastern Han Chinese population.


METHODS
We hypothesized that the CYP2E1-1019T>A and GSTM1 polymorphisms were associated with risk of bladder cancer. In a hospital-based case-control study of 202 case patients with newly diagnosed bladder transitional cell carcinoma and 272 cancer-free controls frequency-matched by the age and sex, we genotyped these two polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism method.


RESULTS
We found that the GSTM1 null genotype was associated with an increased risk of bladder cancer (adjusted odds ratio [OR] = 1.73, 95% confidence interval [CI] = 1.17-2.56) compared with those with the non-null genotype, but the CYP2E1-1019T>A polymorphisms did not show any association. In the stratification analysis of the GSTM1 polymorphism, we found that the increased risk was more pronounced among subgroups aged < or =60 years (OR = 2.02, 95% CI = 1.08-3.77), smokers (OR = 1.94, 95% CI = 1.11-3.38) and non-drinkers (OR = 3.86, 95% CI = 1.28-11.60).


CONCLUSIONS
GSTM1 polymorphism (but not CYP2E1 RsaI polymorphism) appears to contribute to the etiology of bladder cancer in a south-eastern Chinese population.
Shao
Jianfeng
J
Department of Urological Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Gu
Min
M
Zhang
Zhendong
Z
Xu
Zhuoqun
Z
Hu
Qiang
Q
Qian
Lixin
L
D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D019392:Cytochrome P-450 CYP2E1; D005982:Glutathione Transferase