title: In vivo confocal and multiphoton microendoscopy.
abstract: The ability to conduct high-resolution fluorescence imaging in internal organs of small animal models in situ and over time can make a significant impact in biomedical research. Toward this goal, we developed a real-time confocal and multiphoton endoscopic imaging system. Using 1-mm-diameter endoscopes based on gradient index lenses, we demonstrate video-rate multicolor multimodal imaging with cellular resolution in live mice.
authors.affiliation: Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 50 Blossom St., BAR 818, Boston, Massachusetts 02114, USA.
authors.forename: Pilhan
authors.initials: P
authors.lastname: Kim
authors.forename: Mehron
authors.initials: M
authors.lastname: Puoris'haag
authors.forename: Daniel
authors.initials: D
authors.lastname: Côté
authors.forename: Charles P
authors.initials: CP
authors.lastname: Lin
authors.forename: Seok H
authors.initials: SH
authors.lastname: Yun
mesh_terms: D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D018613:Microscopy, Confocal / Q000295:instrumentation*; D036641:Microscopy, Fluorescence, Multiphoton / Q000295:instrumentation*; D008904:Miniaturization; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity