title: Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.
abstract: The placenta is a transitory structure indispensable for the proper development of the embryo and fetus during mammalian gestation. Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the placentation. This placental involvement has been recently reviewed focusing on the early stages of placental development (implantation and invasion, etc.), mouse PPARs knockout phenotypes, and cytotrophoblast physiology. In this review, we describe the placental involvement of PPARs (e.g., fat transport and metabolism, etc.) during the late stages of gestation and in the amniotic membranes, highlighting their roles in the inflammation process (e.g., chorioamnionitis), metabolic disorders (e.g., diabetes), and parturition.
authors.affiliation: Université d'Auvergne, JE 2447, ARDEMO, 63000 Clermont-Ferrand, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Borel
authors.forename: Denis
authors.initials: D
authors.lastname: Gallot
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Marceau
authors.forename: Vincent
authors.initials: V
authors.lastname: Sapin
authors.forename: Loïc
authors.initials: L
authors.lastname: Blanchon