title: Ceruloplasmin, copper, selenium, iron, zinc, and manganese levels in normal and sulfite oxidase deficient rat plasma: effects of sulfite exposure.
abstract: A noticeable effect of sulfite treatment was observed on the plasma ceruloplasmin ferroxidase activity of rats with normal sulfite oxidase activity when compared to normal controls. The plasma levels of selenium, iron, and zinc were unaffected by sulfite in normal and sulfite oxidase (SOX)-deficient rats. While plasma level of Mn was decreasing, plasma Cu level increased in SOX-deficient rats. Treating SOX-deficient groups with sulfite did not alter plasma level of Mn but made plasma level of Cu back to its normal level. This is the first evidence that Cu and Mn status were affected in experimental sulfite oxidase deficiency induced by low molybdenum diet with tungsten addition deserving further research to determine the underlying mechanisms of these observations in experimental sulfite oxidase deficiency.
authors.affiliation: Faculty of Engineering, Food Engineering Department, Pamukkale University, Kinikli, 20020, Denizli, Turkey. nurherken@pau.edu.tr
authors.forename: Emine Nur
authors.initials: EN
authors.lastname: Herken
authors.forename: Erdogan
authors.initials: E
authors.lastname: Kocamaz
authors.forename: Melek Bor
authors.initials: MB
authors.lastname: Kucukatay
authors.forename: Huseyin
authors.initials: H
authors.lastname: Vural
authors.forename: Hilmi
authors.initials: H
authors.lastname: Demirin
authors.forename: Vural
authors.initials: V
authors.lastname: Kucukatay
mesh_terms: D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000097:blood; D007501:Iron / Q000097:blood; D008297:Male; D008345:Manganese / Q000097:blood; D051381:Rats; D012643:Selenium / Q000097:blood; D013054:Spectrophotometry, Atomic; D050876:Sulfite Oxidase / Q000235:genetics; D013447:Sulfites / Q000008:administration & dosage*; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D013447:Sulfites; D014131:Trace Elements; D008345:Manganese; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin; D050876:Sulfite Oxidase; D012643:Selenium; D015032:Zinc