[Screening of effective fraction on experimental gastric ulcer from Pongamia pinnata roots].
OBJECTIVE
To study the effect of extract from Pongamia pinnata roots on experimental gastric ulcer and screen the effective fraction.


METHODS
The models of gastric mucosa damage were induced by absolute alcohol in rats and reserpine in mice to observed the effect of ethyl alcohol extract from P. pinnata roots (PRE) and different parts on experimental gastric ulcer.


RESULTS
PRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. In absolute alcohol models the gastric ulcer rates of inhibition were 86.4%, 85.4%, 11.5%, respectively. In reserpine models the gastric ulcer rates of inhibition were 37.8%, 33.8%, 19.7%, respectively.


CONCLUSIONS
PRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. Acetic ether extract from P. pinnata roots has the best effect on experimental gastric ulcer.
Liu
Ke-Yun
KY
Department of Pharmacology, Institute for Drug Control of Hainan province, Haikou 570216, China.
Zhu
Yi
Y
Chen
Guo-Biao
GB
Dong
Zhi
Z
Zhao
Yu-Mei
YM
Li
Bei
B
Liu
Chun
C
Li
Jing
J
D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000431:Ethanol; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D033641:Millettia / Q000737:chemistry*; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D000431:Ethanol; D012110:Reserpine