title: Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
abstract: Novel, achiral 1H-1,3,5-benzotriazepine-2,4(3H,5H)-diones have been prepared and structurally characterized. These compounds are potent CCK(2) receptor antagonists that display a high degree of selectivity over CCK(1) receptors.
authors.affiliation: James Black Foundation, 68 Half Moon Lane, Dulwich, London SE24 9JE, UK.
authors.forename: John
authors.initials: J
authors.lastname: Spencer
authors.forename: John
authors.initials: J
authors.lastname: Gaffen
authors.forename: Eric
authors.initials: E
authors.lastname: Griffin
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Harper
authors.forename: Ian D
authors.initials: ID
authors.lastname: Linney
authors.forename: Iain M
authors.initials: IM
authors.lastname: McDonald
authors.forename: Sonia P
authors.initials: SP
authors.lastname: Roberts
authors.forename: Mark E
authors.initials: ME
authors.lastname: Shaxted
authors.forename: Trushar
authors.initials: T
authors.lastname: Adatia
authors.forename: Alan
authors.initials: A
authors.lastname: Bashall
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding; D043887:Receptor, Cholecystokinin B / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D001552:Benzazepines; D043887:Receptor, Cholecystokinin B; D014227:Triazines