Plasma pyridoxal 5'-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease.
OBJECTIVE
Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5'-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD.


METHODS
This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects' height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured.


RESULTS
Plasma PLP concentration was only negatively associated with hs-CRP level in the control group (beta = -0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs-CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35).


CONCLUSIONS
Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double.
Cheng
Chien-Hsiung
CH
Critical Care and Respiratory Therapy, Taichung Veterans General Hospital, Taichung, Taiwan.
Lin
Ping-Ting
PT
Liaw
Yung-Po
YP
Ho
Chien-Chang
CC
Tsai
Tsung-Po
TP
Chou
Ming-Chih
MC
Huang
Yi-Chia
YC
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011732:Pyridoxal Phosphate / Q000097:blood* / Q000172:deficiency; D012307:Risk Factors; D025101:Vitamin B 6 / Q000097:blood; D026681:Vitamin B 6 Deficiency / Q000097:blood* / Q000150:complications; D014803:Vitamin B Complex / Q000097:blood
D006710:Homocysteine; D014803:Vitamin B Complex; D011732:Pyridoxal Phosphate; D025101:Vitamin B 6; D002097:C-Reactive Protein; D002784:Cholesterol