Human gene therapy vectors derived from feline lentiviruses.
Lentiviral vectors are useful for gene transfer to dividing and nondividing cells. Feline immunodeficiency virus (FIV) vectors transduce most human cell types with good efficiency and may have advantages for clinical gene therapy applications. This article reviews significant progress in the development and refinement of FIV vector systems.
Barraza
Román A
RA
Molecular Medicine Program, Guggenheim 18, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States. barraza.roman@mayo.edu
Poeschla
Eric M
EM
D000818:Animals; D002415:Cats; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000235:genetics*; D014158:Transcription, Genetic; D014161:Transduction, Genetic