title: Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple.
abstract: A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This procedure employs a highly enantioselective lipase from Pseudomonas stutzeri (trade name, lipase TL) as the resolution catalyst and a ruthenium complex as the racemization catalyst. Sixteen 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields (95-97%) and high enantiomeric excesses (96-99%).
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784, Korea. mjkim@postech.ac.kr
authors.forename: Mahn-Joo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Choi
authors.forename: Sol
authors.initials: S
authors.lastname: Kim
authors.forename: Daeho
authors.initials: D
authors.lastname: Kim
authors.forename: Kiwon
authors.initials: K
authors.lastname: Han
authors.forename: Soo-Byung
authors.initials: SB
authors.lastname: Ko
authors.forename: Jaiwook
authors.initials: J
authors.lastname: Park
mesh_terms: D000431:Ethanol / Q000031:analogs & derivatives*; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000431:Ethanol; D012428:Ruthenium; D008049:Lipase