title: Anti-Müllerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection.
abstract: OBJECTIVE
  To evaluate anti-Müllerian hormone (AMH) as a marker of reproductive outcome after IVF/intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Two hundred seventy-six consecutive women undergoing IVF/ICSI.
  
  
  METHODS
  Ovarian stimulation, oocyte retrieval, IVF, ICSI, embryo transfer, AMH, and inhibin B determinations in serum and follicular fluid (FF).
  
  
  METHODS
  The AMH and inhibin B concentrations in 276 matched FF/serum pairs have been determined. Different outcome groups have been compared and set in relation to the oocyte count, morphological parameters, and steroid hormone levels.
  
  
  RESULTS
  The concentrations of AMH and inhibin B in both serum and FF were significantly higher in the group of women who became pregnant in the corresponding treatment cycle than in those who did not conceive. Positive correlations were observed between serum inhibin B concentrations and embryo morphology (r = 0.126, 95% confidence interval 0.026-0.284). Serum and FF AMH or inhibin B correlated positively with the oocyte count and negatively with the pretreatment cycle day 3 FSH level and the total administered gonadotropin dose.
  
  
  CONCLUSIONS
  The AMH and inhibin B levels on the day of oocyte retrieval are correlated to reproductive outcome.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. dorothea.wunder@insel.ch
authors.forename: Dorothea M
authors.initials: DM
authors.lastname: Wunder
authors.forename: Jean
authors.initials: J
authors.lastname: Guibourdenche
authors.forename: Martin H
authors.initials: MH
authors.lastname: Birkhäuser
authors.forename: Nick A
authors.initials: NA
authors.lastname: Bersinger
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D010064:Embryo Implantation; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007246:Infertility / Q000378:metabolism / Q000628:therapy*; D007265:Inhibins / Q000097:blood / Q000378:metabolism*; D008137:Longitudinal Studies; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; C422364:inhibin B; D011374:Progesterone; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone