title: Relation between serum IL-4, IL-13 and IFN-gamma levels and recurrence of wheezing episodes in infants with acute bronchiolitis.
abstract: Lower respiratory tract infections are the most important factors among various causes which trigger wheezing in the first year of life. The factors associated with episodic wheezing in children with acute bronchiolitis are still subjects of research. Infections, environmental factors, immunologic mechanisms are sorted as etiologic risk factors of episodic wheezing. We aimed to investigate the relationship between serum interleukin (IL)-4, IL-13 and gamma-interferon (IFN-gamma) levels and recurrence of wheezing episodes in infants with acute bronchiolitis. One hundred twenty infants between 3 and 36 months with acute bronchiolitis enrolled in the study. Personal histories, clinical and laboratory data of infants were recorded. The patients were followed for a year. Venous blood samples were obtained to determine serum IL-4, IL-13, and IFN-gamma levels during acute bronchiolitis episode. The number of wheezing episodes was significantly higher in infants with a positive family history of allergy. A statistically significant correlation was determined between serum IL-13 levels of infants and number of wheezing episodes. High serum IL-13 levels and a positive history of allergy may have important roles in the recurrence of acute bronchiolitis.
authors.affiliation: Division of Allergy, Department of Pediatrics, Dokuz Eylul University School of Medicine, Izmir, Turkey. nuzuner@deu.edu.tr
authors.forename: Nevin
authors.initials: N
authors.lastname: Uzuner
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gurcu
authors.forename: Duygu
authors.initials: D
authors.lastname: Olmez
authors.forename: Arzu
authors.initials: A
authors.lastname: Babayigit
authors.forename: Huray
authors.initials: H
authors.lastname: Islekel
authors.forename: Ozkan
authors.initials: O
authors.lastname: Karaman
authors.forename: Dilek
authors.initials: D
authors.lastname: Tezcan
mesh_terms: D000208:Acute Disease; D001988:Bronchiolitis / Q000175:diagnosis* / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood*; D018793:Interleukin-13 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D012008:Recurrence; D012135:Respiratory Sounds / Q000175:diagnosis* / Q000276:immunology
chemical_list: D018793:Interleukin-13; D015847:Interleukin-4; D007371:Interferon-gamma