title: Meibomian gland alterations in polycystic ovary syndrome.
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) is an endocrinopathy characterized by chronic anovulation and hyperandrogenism where hyperinsulinemia can be seen. Hormonal changes can affect meibomian gland function. In this study, we evaluated tear function in PCOS.
  
  
  METHODS
  Twenty-seven women having PCOS and 22 normal individuals aged between 18-42 years were enrolled in the study. Patients were asked about dry eye symptoms. Schirmer test, tear film breakup time, and rose Bengal staining were performed. Conjunctival brush cytology specimens were obtained and goblet cell count was done.
  
  
  RESULTS
  Dry eye symptoms were more frequent in subjects with PCOS (p=0.025). Mean breakup time was shorter in women with PCOS (p=0.034). Schirmer test results, rose Bengal staining scores, and goblet cell count were not different between groups (p=0.48, p=0.18, p=0.82, respectively).
  
  
  CONCLUSIONS
  Meibomian gland function and tear film lipid layer can be affected in cases with PCOS.
authors.affiliation: School of Medicine, Department of Ophthalmology, Afyon Kocatepe University, Afyonkarahisar, Turkey. gkumbar@ttnet.net.tr
authors.forename: Guliz Fatma
authors.initials: GF
authors.lastname: Yavas
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozturk
authors.forename: Tuncay
authors.initials: T
authors.lastname: Kusbeci
authors.forename: Sitki Samet
authors.initials: SS
authors.lastname: Ermis
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmazer
authors.forename: Serhan
authors.initials: S
authors.lastname: Cevrioglu
authors.forename: Fatma
authors.initials: F
authors.lastname: Aktepe
authors.forename: Songul
authors.initials: S
authors.lastname: Kose
mesh_terms: D000328:Adult; D002452:Cell Count; D015352:Dry Eye Syndromes / Q000503:physiopathology*; D005141:Eyelid Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008537:Meibomian Glands / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D013666:Tears / Q000502:physiology