Atenolol reduces salivary activity in pups of spontaneously hypertensive and normotensive rats treated during pregnancy and lactation.
The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance.
Elias
Gracieli P
GP
Pediatric Dentistry Postgraduate Program, School of Dentistry at Araçatuba, São Paulo State University, UNESP, SP, Brazil.
Sassaki
Kikue T
KT
Delbem
Alberto C B
AC
Antoniali
Cristina
C
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D005260:Female; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D007774:Lactation; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism* / Q000473:pathology; D012471:Salivary Proteins and Peptides / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D012471:Salivary Proteins and Peptides; D001262:Atenolol; D000681:Amylases