title: Concise synthesis of 2-amino-4(3H)-quinazolinones from simple (Hetero)aromatic amines.
abstract: A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero)aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution.
authors.affiliation: Département Chimie Moléculaire, UMR 5250, Université Joseph Fourier, BP 53, 38041 Grenoble cedex 9, France.
authors.forename: Walid
authors.initials: W
authors.lastname: Zeghida
authors.forename: Julien
authors.initials: J
authors.lastname: Debray
authors.forename: Sabine
authors.initials: S
authors.lastname: Chierici
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.forename: Martine
authors.initials: M
authors.lastname: Demeunynck
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis*
chemical_list: D000814:Aniline Compounds; D052999:Quinazolinones