title: Olanzapine plasma concentration in a newborn.
abstract: Little is known about the use of antipsychotics in pregnancy and the corresponding plasma levels in the newborn child. We report on a woman with schizophrenia treated with olanzapine during pregnancy. Plasma levels of olanzapine were assessed both from the mother and from umbilical cord. The plasma level of the newborn (11 ng/mL) was about one third compared to the mother (range 25-34 ng/mL).The development of the fetus, delivery and the development of the child during the first six months were normal.
authors.affiliation: Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria. w.aichhorn@salk.at
authors.forename: W
authors.initials: W
authors.lastname: Aichhorn
authors.forename: K
authors.initials: K
authors.lastname: Yazdi
authors.forename: K
authors.initials: K
authors.lastname: Kralovec
authors.forename: H
authors.initials: H
authors.lastname: Steiner
authors.forename: S
authors.initials: S
authors.lastname: Whitworth
authors.forename: C
authors.initials: C
authors.lastname: Stuppaeck
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000097:blood*; D001569:Benzodiazepines / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D000077152:Olanzapine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine