[Acute graft versus host disease in non-myeloablative allogeneic stem cell transplantation].
The objective of this study was to explore the occurrence and clinical features of acute graft versus host disease (aGVHD) in non-myeloablative stem cell transplantation (NAST). 19 cases developed aGVHD out of 71 cases with NAST in recent years were analyzed retrospectively. Out of 19 cases, 9 males and 10 females at the median age of 38 (18-59), 16 cases with grade I-II aGVHD, 3 cases with grade III-IV aGVHD. The results indicated that the incidence of aGVHD in NAST was 26.7% (19/71), and severe aGVHD was 4.2%, the median onset time was 58 days (17-240 days) after transplantation. Skin and especially the intestine were the main target organs of aGVHD, while diarrhea occurred as the first symptom in 7 cases, 3 cases showed mixed acute and chronic GVHD involving more locations at the same time. aGVHD occurrence was 38.2% in those patients with full donor chimerism (FDC) and 16% in patients with the mixed chimerism (MC). It is concluded that aGVHD in NAST is less in occurrence, lighter in severity and later in time, but higher occurrence in those with early FDC, which intestine and skin are the main target organs. The clinical course is prolonged and easily complicated with severe infection in the later phase. Early combined therapy with powerful supportive treatment is necessary.
Qiao
Jian-Hui
JH
Department of Hematology, Affiliated Hospital, Academy of Military Medical Science, Beijing 100071, China.
Wang
Dan-Hong
DH
Yu
Chang-Lin
CL
Guo
Mei
M
Sun
Wan-Jun
WJ
Sun
Qi-Yun
QY
Yao
Bo
B
Zhang
Shi
S
Ai
Hui-Sheng
HS
D000293:Adolescent; D000328:Adult; D016465:Bone Marrow Purging; D002681:China / Q000453:epidemiology; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D055815:Young Adult