title: Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
abstract: Aza TSAO-T derivatives bearing a substituted dihydroisothiazole dioxide ring with a phenyl group at 5'' position were prepared. Biological evaluation showed that phenyl group gives rise to a dramatical decrease of the inhibitory effect.
authors.affiliation: Laboratoire des Glucides (UMR6219), Faculté des Sciences, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Tomassi
authors.forename: Albert
authors.initials: A
authors.lastname: Nguyen Van Nhien
authors.forename: José
authors.initials: J
authors.lastname: Marco-Contelles
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Denis
authors.initials: D
authors.lastname: Postel
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D001372:Aza Compounds; D009705:Nucleosides; D013141:Spiro Compounds