Mechanisms for decreased function of B cells in aged mice and humans.
The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.
Frasca
Daniela
D
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Landin
Ana Marie
AM
Riley
Richard L
RL
Blomberg
Bonnie B
BB
D000375:Aging / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D003564:Cytidine Deaminase / Q000037:antagonists & inhibitors / Q000235:genetics; D015536:Down-Regulation / Q000235:genetics / Q000276:immunology*; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000235:genetics; D051379:Mice; D051820:TCF Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics; D058125:Transcription Factor 7-Like 1 Protein; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D051820:TCF Transcription Factors; C544912:TCF7L1 protein, human; C544913:Tcf7l1 protein, mouse; D058125:Transcription Factor 7-Like 1 Protein; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase