Plasma glutathione levels are independently associated with gamma-glutamyltransferase activity in subjects with cardiovascular risk factors.
To investigate whether GGT (gamma-glutamyltransferase) is associated to specific redox patterns. GGT, total and reduced aminothiols and malondialdehyde, were measured in 150 subjects (83 males, 48 (39-56) years), with none, one or more risk factors. By univariable analysis GGT was positively associated with age (p =0.001), male gender (p <0.001), risk factor number (p <0.001), ACE-inhibitors (p =0.008), anti-platelet agents (p =0.029), atherothrombotic events (p =0.001), glucose (p =0.013), malondialdehyde (p =0.029), plasma total cysteine (p =0.046) and inversely associated with plasma total glutathione (p =0.001). By multivariable analysis only male gender (p <0.001), risk factor number (p <0.001) and glutathione (p <0.001) were independently associated with GGT activity. These findings suggest that an ongoing redox imbalance, in terms of decreased plasma glutathione, is associated with raised GGT activity in subjects with a greater risk factor burden.
Sedda
Valentina
V
CNR Clinical Physiology Institute-Milan, Italy.
De Chiara
Benedetta
B
Parolini
Marina
M
Caruso
Raffaele
R
Campolo
Jonica
J
Cighetti
Giuliana
G
De Maria
Renata
R
Sachero
Aldo
A
Donato
Luigi
L
Parodi
Oberdan
O
D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000453:epidemiology*; D005783:Gender Identity; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010949:Plasma / Q000737:chemistry / Q000201:enzymology*; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
D008315:Malondialdehyde; D005723:gamma-Glutamyltransferase; D005978:Glutathione