kdr: can a single mutation produce an entire insecticide resistance phenotype?
Knockdown resistance (kdr) is closely associated with DDT and pyrethroid resistance in the major malaria vector Anopheles gambiae and is considered to be causative of the resistance phenotype. The same association does not apply to Sudanese populations of the closely related malaria vector A. arabiensis. Speculation on this discrepancy and on the incidence of multiple insecticide resistance and cross-resistance has implications for the manner in which entomological surveys are conducted in the field as well as on the array of technologies employed to produce usable data.
Brooke
Basil D
BD
Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Sandringham, South Africa. basilb@nicd.ac.za
D000818:Animals; D000852:Anopheles / Q000235:genetics*; D003634:DDT; D007303:Insect Vectors / Q000187:drug effects / Q000235:genetics*; D007305:Insecticide Resistance / Q000235:genetics*; D007306:Insecticides; D009032:Mosquito Control; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D011722:Pyrethrins
D007306:Insecticides; D011722:Pyrethrins; D003634:DDT