title: [Beta-ionone induced apoptosis in SGC-7901 cells].
abstract: OBJECTIVE
  In order to determine the inhibitory effects and apoptosis of beta-ionone in human gastric carcinoma SGC-7901 cell line and its possible mechanism.
  
  
  METHODS
  The assays of the curves of cell proliferation, cell mitosis, Hoechst 33258 dye stained, emission electronic microscope, and western blotting were employed.
  
  
  RESULTS
  Beta-ionone could inhibit the growth and cell mitosis in SGC-7901 cells. The EC50 value was (174.93 +/- 12.79) micromol/L. Morphology of apoptosis was observed by Hoechst 33258 dye stained and emission electronic microscope. The fragmentation of activated caspase-3 was induced and expression of Erkl/2 protein was decreased in SGC-7901 cells treated with different levels of beta-ionone.
  
  
  CONCLUSIONS
  Thus beta-ionone could induce apoptosis in SGC-7901 cells and exactly mechanism needed further to be studied.
authors.affiliation: Department of Environmental Health, Public Health College, Harbin Medical University, Harbin 150086, China.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Sun
authors.forename: Jiaren
authors.initials: J
authors.lastname: Liu
authors.forename: Wenguang
authors.initials: W
authors.lastname: Sun
authors.forename: Xuanle
authors.initials: X
authors.lastname: Tang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D045792:Norisoprenoids / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045792:Norisoprenoids; C008157:beta-ionone; D048052:Mitogen-Activated Protein Kinase 3; C505407:CASP3 protein, human; D053148:Caspase 3