Vascular endothelial growth factor 936 C/T polymorphism is associated with vascular invasion in oral squamous cell carcinoma.
OBJECTIVE
The objective of this study was to analyze the relation of VEGF 936 C/T polymorphisms in progression of oral squamous cell carcinoma (OSCC) patients and healthy subjects in Taiwan.


METHODS
We genotyped 218 patients with OSCC, comparing the genotypes and gene frequencies with those of 121 control subjects. VEGF 936 C/T polymorphisms were determined by using polymerase chain reaction and restriction fragment length polymorphism.


RESULTS
There were no significant differences in genotype, phenotype, or gene frequency between the OSCC and control groups. Among patients with OSCC, there were also no significant differences in the polymorphism between those with and without cervical lymph node metastases or in survival. However, 21 of the 218 patients had vascular invasion by their OSCC, and these patients were significantly more likely to have a C/C (P = .033) or C/T genotype (P = .026) than were those without vascular invasion.


CONCLUSIONS
This study suggests that the VEGF 936 C allele is associated with vascular invasion in OSCC.
Cheng
Chieh-Yuan
CY
Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
Chang
Che-Shoa
CS
Liu
Chung-Ji
CJ
Kao
Shou-Yen
SY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000098:blood supply* / Q000235:genetics; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000098:blood supply* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D004273:DNA, Neoplasm; D042461:Vascular Endothelial Growth Factor A