[Recent advances in the study of antifungal lead compounds with new chemical scaffolds].
In recent years, the incidence of infections caused by invasive fungal pathogens has increased dramatically. However, most antifungal agents used in clinic have many drawbacks and cannot meet the demand of the clinical use. Therefore, for the development of new generation of antifungal agents, it is of great significance to find antifungal lead compounds with novel chemical scaffolds and new mode of action. Novel antifungal lead compounds reported in recent years are reviewed. Their chemical structures, antifungal activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.
Shao
Lü-cheng
LC
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Sheng
Chun-quan
CQ
Zhang
Wan-nian
WN
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001599:Berberine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D002777:Cholestanols / Q000737:chemistry / Q000494:pharmacology; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D002777:Cholestanols; D006571:Heterocyclic Compounds; D007783:Lactones; D009285:Naphthoquinones; D011725:Pyridines; C101439:UK 2A; C094022:incrustoporin; D001599:Berberine; D003515:Cycloleucine; C065594:cispentacin; C079655:squalamine; D015107:4-Butyrolactone