title: Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome.
abstract: We report the case of a 19-month-old male child with diarrhea-associated hemolytic uremic syndrome (HUS) who developed swelling of the right arm at the site of a peripherally inserted central venous catheter (PICC), fever, and later, ecchymosis. Wound cultures at the time of surgical debridement grew Clostridium septicum. The child subsequently required amputation of the right arm and prolonged therapy with parenteral penicillin and clindamycin. Clostridium septicum infections in children with HUS have been associated with a high rate of mortality. Along with colon cancer, diarrhea-associated HUS comprises a clinical entity which appears to predispose to atraumatic C. septicum infection, where acidic and anaerobic conditions in the diseased colon favor C. septicum invasion. Though not well recognized among pediatric nephrologists, C. septicum infection constitutes a severe, albeit rare, complication of diarrhea-associated HUS, but one in which a high index of suspicion is warranted as aggressive surgical and antibiotic therapy may be life-saving.
authors.affiliation: Division of Pediatric Nephrology, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, TN 37232-9560, USA. tray.hunley@vanderbilt.edu
authors.forename: Tracy E
authors.initials: TE
authors.lastname: Hunley
authors.forename: Michele D
authors.initials: MD
authors.lastname: Spring
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Peters
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Weikert
authors.forename: Kathy
authors.initials: K
authors.lastname: Jabs
mesh_terms: D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001132:Arm; D003015:Clostridium Infections / Q000150:complications / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D052557:Clostridium septicum / Q000302:isolation & purification*; D003131:Combined Modality Therapy; D003646:Debridement; D003968:Diarrhea, Infantile / Q000150:complications*; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D018482:Muscle, Skeletal / Q000382:microbiology* / Q000473:pathology; D009135:Muscular Diseases / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D009336:Necrosis; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents