title: Insight into initiator-DNA interactions: a lesson from the archaeal ORC.
abstract: Although initiation of DNA replication is considered to be highly coordinated through multiple protein-DNA and protein-protein interactions, it is poorly understood how particular locations within the eukaryotic chromosome are selected as origins of DNA replication. Here, we discuss recent reports that present structural information on the interaction characteristics of the archaeal orthologues of the eukaryotic origin recognition complex with their cognate binding sequences. Since the archaeal replication system is postulated as a simplified version of the one in eukaryotes, by analogy, these works provide insights into the functions of the eukaryotic initiator proteins.
authors.affiliation: Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan. tada@mail.pharm.tohoku.ac.jp
authors.forename: Shusuke
authors.initials: S
authors.lastname: Tada
authors.forename: Lena R
authors.initials: LR
authors.lastname: Kundu
authors.forename: Takemi
authors.initials: T
authors.lastname: Enomoto
mesh_terms: D019843:Archaeal Proteins / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D002874:Chromosome Mapping; D002875:Chromosomes; D004247:DNA / Q000378:metabolism*; D004261:DNA Replication; D004926:Escherichia coli / Q000378:metabolism; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D051738:Origin Recognition Complex; D017434:Protein Structure, Tertiary; D018741:Replication Origin
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D051738:Origin Recognition Complex; D004247:DNA