title: Sleep, hypnotics and chronic obstructive pulmonary disease.
abstract: The quality of sleep is significantly compromised in many patients with chronic obstructive pulmonary disease (COPD) and may be further diminished when certain comorbidities are present. A reduced sleep quality is associated with daytime consequences like fatigue, psychiatric problems and an impaired quality of life. Sleep induces physiologic alterations in respiratory function, which can become pathologic and may provoke or worsen hypoxemia and hypercapnia in COPD. Dyspnea, cough and excessive mucus production should be optimised to minimise causes for sleep disturbance. Pharmacological therapy may be helpful; sedatives like benzodiazepines and non-benzodiazepine benzodiazepine-receptor agonists (NBBRAs) are (equally) effective in improving sleep quality. Whether or not these hypnotics produce serious adverse respiratory effects during sleep, remains unclear due to opposing studies. Therefore, their use should be as short as possible.
authors.affiliation: Department of Pulmonology, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The Netherlands. gstege@alysis.nl <gstege@alysis.nl>
authors.forename: Gerben
authors.initials: G
authors.lastname: Stege
authors.forename: Petra J E
authors.initials: PJ
authors.lastname: Vos
authors.forename: Frank J J
authors.initials: FJ
authors.lastname: van den Elshout
authors.forename: P N
authors.initials: PN
authors.lastname: Richard Dekhuijzen
authors.forename: Marjo J T
authors.initials: MJ
authors.lastname: van de Ven
authors.forename: Yvonne F
authors.initials: YF
authors.lastname: Heijdra
mesh_terms: D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology*
chemical_list: D006993:Hypnotics and Sedatives