title: [Multivariate analysis of impact of different neck treatment and prognostic factors affecting disease-free survival in patients with early-staged squamous cell carcinoma of tongue].
abstract: OBJECTIVE
  To analyze the prognostic factors affecting the disease-free survival in T1/T2N0M0-staged patients with squamous cell carcinoma of tongue and compare the effectiveness of different neck treatment modalities.
  
  
  METHODS
  97 consecutive patients with early-staged squamous cell carcinoma of tongue were included in this study. The treatment and following-up records were reviewed retrospectively. Cox proportional hazard model was used to identify the statistically significant prognostic factors in the 6 potential factors. Kaplan-Meier method was used to estimate the disease-free survival and analyze the survival rate among the different levels, and log-rank method for comparison of the different distribution of the survival. A special focus was on the effectiveness of different neck treatment modalities.
  
  
  RESULTS
  T stage, treatment methods of primary tumor, the modalities of neck treatment and cell differentiation were statistically significant prognostic factors. The value of P and relative risk (RR) were P < 0.001, RR = 4.387; P = 0.04, RR = 0.496; P = 0.003, RR = 0.504; P < 0.001, RR = 2.620, respectively. The difference of disease-free survival was statistically significant among the different levels under the different factors.
  
  
  CONCLUSIONS
  The disease-free survival was affected by neck treatment modalities remarkably in cN0 stage patients. Selected neck dissection together with adjuvant irradiation could decrease the recurrence risk by 49.6% according to the results of this study. TNM stage system could describe the characteristics of the patients with early-staged squamous cell carcinoma of tongue reasonably.
authors.affiliation: Dept of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, Jinan 250012, China.
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Liu
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Liu
authors.forename: Chu-Hui
authors.initials: CH
authors.lastname: Yang
authors.forename: Zheng-Hua
authors.initials: ZH
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell; D018572:Disease-Free Survival; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D037981:Neck Dissection; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D014062:Tongue Neoplasms