Concise synthesis of enantiomers of 4-aminobutane-1,2,3-triol.
A very efficient synthesis of (2R,3S) and (2S,3R)-4-aminobutane-1,2,3-triol has been developed using either d- or l-glucose as the starting material. A key step is the one-pot conversion of an aldehyde to an amide, the scope of which has been extended to include other carbohydrate-derived aldehydes.
Dunlap
Norma K
NK
Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, USA. ndunlap@mtsu.edu
Drake
John
J
Ward
Andrea
A
Salyard
Tracy L J
TL
Martin
Leah
L
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002082:Butylamines / Q000138:chemical synthesis* / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000438:Alcohols; D002082:Butylamines; D005947:Glucose