Sequencing of subcloned PCR products facilitates earlier detection of BCR-ABL1(T315I) and other mutants compared to direct sequencing of the ABL1 kinase domain.
Quintás-Cardama
A
A
Gibbons
D L
DL
Kantarjian
H
H
Talpaz
M
M
Donato
N
N
Cortes
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis / Q000379:methods* / Q000592:standards; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D016315:Proto-Oncogene Proteins c-abl / Q000235:genetics*; D017422:Sequence Analysis, DNA
D016315:Proto-Oncogene Proteins c-abl