title: The effect of Korean pine nut oil (PinnoThin) on food intake, feeding behaviour and appetite: a double-blind placebo-controlled trial.
abstract: Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). In the current study, the effects of a Korean pine nut oil product, PinnoThin, at doses 2 g, 4 g and 6 g triglyceride (TG) and 2 g free fatty acid (FFA), on food intake and appetite were examined in a cross-over double-blind placebo-controlled randomised counter-balanced design in 42 overweight female volunteers. 2 g FFA PinnoThin, given 30 minutes prior to an ad-libitum buffet test lunch, significantly reduced food intake (gram) by 9% (F(4,164) = 2.637, p = 0.036) compared to olive oil control. No significant effect of PinnoThin on macronutrient intake or ratings of appetite were observed. Given the recent data showing that the TG form of PinnoThin may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime. Collectively, these data suggest that PinnoThin may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings.
authors.affiliation: School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK. georgina.hughes@liverpool.ac.uk
authors.forename: Georgina M
authors.initials: GM
authors.lastname: Hughes
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Boyland
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Williams
authors.forename: Louise
authors.initials: L
authors.lastname: Mennen
authors.forename: Corey
authors.initials: C
authors.lastname: Scott
authors.forename: Tim C
authors.initials: TC
authors.lastname: Kirkham
authors.forename: Joanne A
authors.initials: JA
authors.lastname: Harrold
authors.forename: Hiskias G
authors.initials: HG
authors.lastname: Keizer
authors.forename: Jason Cg
authors.initials: JC
authors.lastname: Halford
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001066:Appetite / Q000187:drug effects*; D002214:Capsules; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009753:Nutritive Value; D009754:Nuts / Q000737:chemistry*; D028223:Pinus; D010919:Placebos; D010938:Plant Oils / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D002214:Capsules; D010919:Placebos; D010938:Plant Oils