Protective effect of lignans against sepsis from the roots of Saururus chinensis.
In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saururus chinensis, twelve lignans, sarisan (1), erythro-austrobailignan-6 (2), meso-dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-alpha (TNF-alpha) and alanine aminotransferase (ALT) activity in mice administered LPS/D-GalN.
Seo
Chang-Seob
CS
College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
Lee
Yeun-Kyung
YK
Kim
Young-Jin
YJ
Jung
Jun-Sub
JS
Jahng
Yurngdong
Y
Chang
Hyun-Wook
HW
Song
Dong-Keun
DK
Son
Jong-Keun
JK
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004195:Disease Models, Animal; D017705:Lignans / Q000302:isolation & purification / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D032134:Saururaceae / Q000737:chemistry*; D018805:Sepsis / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology
D016207:Cytokines; D017705:Lignans; D008070:Lipopolysaccharides; D010936:Plant Extracts; C482199:lipopolysaccharide, E coli O55-B5; D000410:Alanine Transaminase