Psychiatric manifestations in Wilson's disease: a cross-sectional analysis.
Behavioral and psychiatric abnormalities in Wilson's disease (WD) have a variable frequency and spectrum. This study involved evaluation of the psychiatric comorbidities in patients of Wilson's disease, using structured clinical interview for DSM-IV Axis-I disorders (SCID). Among the 50 confirmed patients with Wilson's disease recruited for this study, 12 patients (24%) fulfilled the diagnostic criteria for syndromic psychiatric diagnosis: bipolar affective disorder (18%), major depression (4%), and dysthymia (2%). Formal assessment of psychopathology in all patients with Wilson's disease may have therapeutic significance.
Shanmugiah
A
A
Department of Neurology, NIMH and Neurosciences (NIMHANS), Hosur Road, Bangalore-560 029, Karnataka, India.
Sinha
S
S
Taly
A B
AB
Prashanth
L K
LK
Tomar
M
M
Arunodaya
G R
GR
Reddy
Janardhana Y C
JY
Khanna
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D017831:Diagnosis, Dual (Psychiatry); D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006527:Hepatolenticular Degeneration / Q000453:epidemiology*; D006801:Humans; D007406:Interview, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D011569:Psychiatric Status Rating Scales