Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors.
BACKGROUND
Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis.


METHODS
In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V.


RESULTS
Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment.


CONCLUSIONS
Apoptosis can be quantified using (99m)Tc EC-annexin V.
Kurihara
Hiroaki
H
Department of Experimental Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Yang
David J
DJ
Cristofanilli
Massimo
M
Erwin
William D
WD
Yu
Dong-Fang
DF
Kohanim
Saady
S
Mendez
Richard
R
Kim
E Edmund
EE
D000328:Adult; D000368:Aged; D017304:Annexin A5 / Q000138:chemical synthesis; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000138:chemical synthesis; D011446:Prospective Studies; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D017304:Annexin A5; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C433841:technetium Tc 99m ethylenedicysteine annexin V