A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols.
A highly selective method to protect the 11 beta-OH position of steroid (1) has been developed. This is achieved via double silyl protection of the 11 beta, 17 alpha-diol, followed by selective desilylation of the 17 alpha-OH under basic conditions without the need for a fluoride source.
Glossop
Paul A
PA
Pfizer Global R & D, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.
Hoogenraad
Marcel
M
Peakman
Torren M
TM
Roberts
Dannielle F
DF
D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship
D013256:Steroids