title: Clinical course of neuropathologically confirmed frontal-variant Alzheimer's disease.
abstract: Background A 66-year-old man presented with a 3-year history of personality changes marked by increasing apathy, social withdrawal and deficits in complex attention, and a 1-year history of progressive memory problems and difficulties in planning and carrying out complex tasks. Investigations Three neuropsychological examinations over 2 years, neurological examination, routine laboratory tests, brain MRI, single-photon emission CT scan, genetic analyses, and neuropathological examination. Diagnosis A clinical diagnosis of frontal-variant frontotemporal dementia was superseded by postmortem neuropathological evidence, which established a diagnosis of frontal-variant Alzheimer's disease. Management The patient and his spouse were referred for counseling, and the patient was referred for follow-up examinations.
authors.affiliation: Marie Curie Fellow at the University of Cambridge, Cambridge, UK.
authors.forename: Kirsten I
authors.initials: KI
authors.lastname: Taylor
authors.forename: Alphonse
authors.initials: A
authors.lastname: Probst
authors.forename: André R
authors.initials: AR
authors.lastname: Miserez
authors.forename: Andreas U
authors.initials: AU
authors.lastname: Monsch
authors.forename: Markus
authors.initials: M
authors.lastname: Tolnay
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology*; D001526:Behavioral Symptoms / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000175:diagnosis / Q000473:pathology / Q000523:psychology