Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug.
A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6-Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug.
Bifulco
Maurizio
M
Dipartmento di Scienze Farmaceutiche, Università di Salerno, 84084 Fisciano, SA, Italy. maubiful@unisa.it
Malfitano
Anna Maria
AM
Proto
Maria Chiara
MC
Santoro
Antonietta
A
Caruso
Maria Gabriella
MG
Laezza
Chiara
C
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007541:Isopentenyladenosine / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D000970:Antineoplastic Agents; D007541:Isopentenyladenosine