title: Hepatocellular carcinoma and occupation in men: a case-control study.
abstract: OBJECTIVE
  The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations.
  
  
  METHODS
  This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects.
  
  
  RESULTS
  An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0-19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8-5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years.
  
  
  CONCLUSIONS
  Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.
authors.affiliation: Inserm Unité 754-IFR 69, Villejuif, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Ferrand
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cénée
authors.forename: Pierre
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Loriot
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Trinchet
authors.forename: Françoise
authors.initials: F
authors.lastname: Degos
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bronovicky
authors.forename: Gilles
authors.initials: G
authors.lastname: Pelletier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stücker
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000453:epidemiology*; D016022:Case-Control Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007407:Interviews as Topic; D008113:Liver Neoplasms / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations / Q000145:classification*; D012307:Risk Factors; D013997:Time Factors