Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery.
Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas co-regulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.
Montecino
Martin
M
Laboratory of Cellular and Molecular Biology, Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Concepcion, Casilla 160-C, Concepcion, Chile. mmonteci@udec.cl
Stein
Gary S
GS
Stein
Janet L
JL
Lian
Jane B
JB
van Wijnen
Andre J
AJ
Carvallo
Loreto
L
Marcellini
Sylvain
S
Cruzat
Fernando
F
Arriagada
Gloria
G
D000818:Animals; D001846:Bone Development / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014807:Vitamin D / Q000502:physiology*
D046912:Multiprotein Complexes; D014157:Transcription Factors; D014807:Vitamin D