Unusual detritylation of tritylated tetrazole in Sartan molecules.
Tritylated tetrazole of 2a underwent unusual detritylation under basic reaction condition during the synthesis of methyl ether of olmesartan medoxomil 1. The unusual detritylation was found to be a common feature in the case of all tetrazole containing Sartan molecules (3-7).
Srimurugan
Sankareswaran
S
Department of Process Chemistry, Advinus Therapeutics, Bangalore-560058, India.
Suresh
Paulsamy
P
Babu
Balaji
B
Hiriyanna
Salmara Ganeshbhat
SG
Pati
Hari Narayan
HN
D047228:Angiotensin II Type 1 Receptor Blockers / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D007093:Imidazoles / Q000737:chemistry; D007553:Isotope Labeling; D013777:Tetrazoles / Q000737:chemistry*; D014316:Tritium / Q000737:chemistry
D047228:Angiotensin II Type 1 Receptor Blockers; D007093:Imidazoles; D013777:Tetrazoles; D014316:Tritium; C437965:olmesartan