Recent advances in andrology-related stem cell research.
Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the former is lagging in reaching clinical applications because of ethical concerns and governmental restrictions. Bone marrow stem cells (BMSC) are the best-studied adult stem cells (ASC) and have the potential to treat a wide variety of diseases, including erectile dysfunction (ED) and male infertility. More recently discovered adipose tissue-derived stem cells (ADSC) are virtually identical to bone marrow stem cells in differentiation and therapeutic potential, but are easier and safer to obtain, can be harvested in larger quantities, and have the associated benefit of reducing obesity. Therefore, ADSC appear to be a better choice for future clinical applications. We have previously shown that ESC could restore the erectile function of neurogenic ED in rats, and we now have evidence that ADSC could do so as well. We are also investigating whether ADSC can differentiate into Leydig, Sertoli and male germ cells. The eventual goal is to use ADSC to treat male infertility and testosterone deficiency.
Lin
Ching-Shwun
CS
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California-San Francisco, CA 94143, USA. clin@urology.ucsf.edu
Xin
Zhong-Cheng
ZC
Deng
Chun-Hua
CH
Ning
Hongxiu
H
Lin
Guiting
G
Lue
Tom F
TF
D053687:Adult Stem Cells; D000818:Animals; D017690:Cell Transplantation; D053595:Embryonic Stem Cells; D007172:Erectile Dysfunction / Q000628:therapy*; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D012106:Research