title: Safety of intramyocardial stem cell therapy for the ischemic myocardium: results of the Rostock trial after 5-year follow-up.
abstract: Stem cell treatment for acute or chronic ischemic myocardium has gained major attention in the last decade. Experimental and clinical studies have shown evidence for functional improvement after cell-based treatments in acute or chronically ischemic jeopardized myocardium. Since 2001 we have performed bone marrow-derived CD133+ stem cell transplantations with concomitant coronary artery bypass surgery. Although our focus is mainly on the functional results of the stem cell treatment, possible long-term side effects of the new therapeutic strategy should also be addressed. Here we present for the first time the long-term follow-up safety results of the Rostock trial after direct intramyocardial stem cell treatment in 32 patients.
authors.affiliation: Department of Cardiac Surgery, University of Rostock, Rostock, Germany.
authors.forename: Can
authors.initials: C
authors.lastname: Yerebakan
authors.forename: Alexander
authors.initials: A
authors.lastname: Kaminski
authors.forename: Andreas
authors.initials: A
authors.lastname: Liebold
authors.forename: Gustav
authors.initials: G
authors.lastname: Steinhoff
mesh_terms: D015703:Antigens, CD / Q000008:administration & dosage; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D001026:Coronary Artery Bypass / Q000379:methods; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D015552:Injections, Intralesional; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D015703:Antigens, CD