title: Formal total synthesis of fostriecin via 1,4-asymmetric induction using cobalt-alkyne complex.
abstract: The synthesis of a protected dephosphofostriecin, and thereby a formal synthesis of fostriecin, has been accomplished. Two of the four chiral centers are controlled by an external chiral auxiliary and the other two are synthesized stereoselectively, one by a novel 1,4-asymmetric induction using cobalt-alkyne complex, and the other by 1,3-asymmetric induction.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Maya
authors.initials: M
authors.lastname: Toyoshima
authors.forename: Kotaro
authors.initials: K
authors.lastname: Okado
authors.forename: Takumi
authors.initials: T
authors.lastname: Toyo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Shoji
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D015394:Molecular Structure; D011090:Polyenes; D011753:Pyrones / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000475:Alkenes; D000480:Alkynes; D011090:Polyenes; D011753:Pyrones; D003035:Cobalt; C040313:fostriecin