title: Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients.
abstract: OBJECTIVE
  To evaluate the oxidative status and antioxidant defense in patients with acute lymphoblastic leukemia (ALL).
  
  
  METHODS
  We measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasmatic and erythrocyte thiol levels and serum vitamin E concentration. This study was performed on 80 children with ALL divided into 4 groups: just diagnosed, remission induction, remission maintenance and out-of-treatment.
  
  
  RESULTS
  TBARS levels and serum protein carbonylation were higher in ALL patients than in controls and reduced levels of antioxidants were found in these patients.
  
  
  CONCLUSIONS
  These findings may indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistence of oxidative stress in acute lymphoblastic leukemia.
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Battisti
authors.forename: Liési D K
authors.initials: LD
authors.lastname: Maders
authors.forename: Margarete D
authors.initials: MD
authors.lastname: Bagatini
authors.forename: Karen F
authors.initials: KF
authors.lastname: Santos
authors.forename: Rosélia M
authors.initials: RM
authors.lastname: Spanevello
authors.forename: Paula A
authors.initials: PA
authors.lastname: Maldonado
authors.forename: Alice O
authors.initials: AO
authors.lastname: Brulé
authors.forename: Maria do Carmo
authors.initials: Mdo C
authors.lastname: Araújo
authors.forename: Maria R C
authors.initials: MR
authors.lastname: Schetinger
authors.forename: Vera M
authors.initials: VM
authors.lastname: Morsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology
chemical_list: D000975:Antioxidants