title: Intraoperative parathyroid hormone levels measured by intact and whole parathyroid hormone assays in patients with Graves' disease.
abstract: OBJECTIVE
  To find out if the whole parathyroid hormone (wPTH) assay has practical advantages over the intact (iPTH) assay in patients with Graves' disease.
  
  
  METHODS
  We measured iPTH and wPTH levels before and after subtotal thyroidectomy in 111 consecutive patients (94 women and 17 men) with Graves' disease. Blood samples for assays were obtained after the induction of anesthesia (basal) and following skin closure (postoperative).
  
  
  RESULTS
  There was a significant correlation between wPTH and iPTH in both the basal and postoperative levels. Logistic regression analyses examining the relationship between the reduction in parathyroid hormone (PTH) levels and the incidence of tetany revealed that both the wPTH and iPTH assays were significantly equally predictive of postoperative tetany.
  
  
  CONCLUSIONS
  We found that both the wPTH and iPTH assays were useful for predicting postoperative tetany in patients with Graves' disease, yielding similar results.
authors.affiliation: Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Oita, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Kai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamashita
authors.forename: Tom
authors.initials: T
authors.lastname: Cantor
authors.forename: Taiki
authors.initials: T
authors.lastname: Moriyama
authors.forename: Masae
authors.initials: M
authors.lastname: Rai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ogawa
authors.forename: Shin
authors.initials: S
authors.lastname: Watanabe
authors.forename: Shinya
authors.initials: S
authors.lastname: Uchino
authors.forename: Shiro
authors.initials: S
authors.lastname: Noguchi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000601:surgery*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013746:Tetany / Q000097:blood*; D013965:Thyroidectomy / Q000009:adverse effects*
chemical_list: D010281:Parathyroid Hormone