title: Towards a new attenuating compound: a potentiometric, spectrophotometric and NMR equilibrium study on Fe(III), Al(III) and a new tetradentate mixed bisphosphonate-hydroxypyridinonate ligand.
abstract: Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of simultaneous coordination of both groups to the same metal ion. Quantum mechanical calculations confirm this finding allowing to determine the minimal length of the linker necessary for a stable conformation of complexes in which Fe(III) is coordinated both by pyridinone and bisphosphonate groups.
authors.affiliation: Centro Interdipartimentale per lo Studio dei Metalli in Medicina, Dipartimento di Scienze Chimiche, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Crisponi
authors.forename: Valeria Marina
authors.initials: VM
authors.lastname: Nurchi
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pivetta
authors.forename: Joanna
authors.initials: J
authors.lastname: Gałezowska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Gumienna-Kontecka
authors.forename: Théodorine
authors.initials: T
authors.lastname: Bailly
authors.forename: Ramon
authors.initials: R
authors.lastname: Burgada
authors.forename: Henryk
authors.initials: H
authors.lastname: Kozłowski
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011199:Potentiometry; D011728:Pyridones / Q000737:chemistry*; D011789:Quantum Theory; D013057:Spectrum Analysis
chemical_list: D004164:Diphosphonates; D005290:Ferric Compounds; D008024:Ligands; D011728:Pyridones; D000535:Aluminum