title: Lack of association between apolipoprotein E polymorphism and vascular dementia in Koreans.
abstract: To investigate an association of vascular dementia (VD) with the apolipoprotein E (APOE) polymorphism, the APOE polymorphism of 100 VD patients, 100 age- and gender-matched Alzheimer disease (AD) patients, and 200 age- and gender-matched nondemented control (NC) subjects was genotyped. The distribution of APOE polymorphism was compared. Neither the APOE epsilon4 allele nor the APOE epsilon2 allele was more prevalent in the VD patients compared with the NC subjects (P > .1 by the chi 2 test), which was the case when both men and women were analyzed separately (P > .1 by the chi2 test) and when young patients (75 years old or less) and old patients (more than 75 years old) were analyzed separately (P > .1 by the chi2 test). The estimated statistical power was over 0.80 when the odds ratios (OR) for VD conferred to the APOE epsilon4 are assumed to be higher than 2.2 and the type I error probability is set at 0.05, which is much higher than the power of the previous studies on the VD/APOE association. In conclusion, the results suggested that APOE epsilon4 allele does not confer the risk for VD, and even if it does, it does so very modestly.
authors.affiliation: Department of Neuropsychiatry and Stroke Center, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
authors.forename: Jong-Chul
authors.initials: JC
authors.lastname: Youn
authors.forename: Moon-Ku
authors.initials: MK
authors.lastname: Han
authors.forename: Nam Jong
authors.initials: NJ
authors.lastname: Paik
authors.forename: Tae Joo
authors.initials: TJ
authors.lastname: Lee
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Park
authors.forename: Seok Bum
authors.initials: SB
authors.lastname: Lee
authors.forename: Il Han
authors.initials: IH
authors.lastname: Choo
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Jin Hyeong
authors.initials: JH
authors.lastname: Jhoo
authors.forename: Jong Inn
authors.initials: JI
authors.lastname: Woo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D015140:Dementia, Vascular / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E