title: Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model.
abstract: In this report, we have addressed the effect of oral administration of a hydrophilic extract of the fern Polypodium leucotomos (PL) on the deleterious effects of ultraviolet radiation (UVR) on the levels of epidermal and plasmatic antioxidants in hairless rats. We have found that pretreatment with PL effectively reduced glutathione oxidation in both blood and epidermis, suggesting a potent systemic antioxidant effect. In addition, PL inhibited UVR-mediated Langerhans cell (LC) depletion. Our results demonstrate the efficacy of PL as an oral antioxidant and photoimmunoprotective agent and support its employment as a complement to topical sunscreens.
authors.affiliation: Department of Pharmacology, School of Medicine and Health Sciences, University Rovira i Virgili, Reus, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Mulero
authors.forename: Esperanza
authors.initials: E
authors.lastname: Rodríguez-Yanes
authors.forename: María Rosa
authors.initials: MR
authors.lastname: Nogués
authors.forename: Montserrat
authors.initials: M
authors.lastname: Giralt
authors.forename: Marta
authors.initials: M
authors.lastname: Romeu
authors.forename: Salvador
authors.initials: S
authors.lastname: González
authors.forename: Jordi
authors.initials: J
authors.lastname: Mallol
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002452:Cell Count; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects / Q000528:radiation effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D019803:Glutathione Disulfide / Q000097:blood / Q000378:metabolism; D007801:Langerhans Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D008297:Male; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000008:administration & dosage; D032494:Polypodium; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D051381:Rats; D054772:Rats, Hairless; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D002374:Catalase; D005978:Glutathione; D019803:Glutathione Disulfide