Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.
Liu
Yi
Y
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA.
Curlin
Marcel E
ME
Diem
Kurt
K
Zhao
Hong
H
Ghosh
Ananta K
AK
Zhu
Haiying
H
Woodward
Amanda S
AS
Maenza
Janine
J
Stevens
Claire E
CE
Stekler
Joanne
J
Collier
Ann C
AC
Genowati
Indira
I
Deng
Wenjie
W
Zioni
Rafael
R
Corey
Lawrence
L
Zhu
Tuofu
T
Mullins
James I
JI
D018562:Disease Transmission, Infectious; D005260:Female; D015686:Gene Products, env / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006031:Glycosylation; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019302:HIV Envelope Protein gp160 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160