Radioprotective properties of eckol against ionizing radiation in mice.
We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients.
Park
Eunjin
E
Department of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690-756, South Korea.
Ahn
Gin-nae
GN
Lee
Nam Ho
NH
Kim
Jeong Mi
JM
Yun
Jin Seok
JS
Hyun
Jin Won
JW
Jeon
You-Jin
YJ
Wie
Myung Bok
MB
Lee
Young Jae
YJ
Park
Jae Woo
JW
Jee
Youngheun
Y
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D049109:Cell Proliferation / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D004147:Dioxins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects
D004147:Dioxins; D011837:Radiation-Protective Agents; C060311:eckol