[Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors].
It was investigated the influence of pineal gland's peptides (epithalamin, epithalon) and indols (melatonin) on the aging changes of circannual rhythms of stromal cells-precurcors (CFC-F), granulocyte-macrophage cells-precurcors (CFC-GM), CD4+, Mac-1+ and CD19+-cells amount in bone marrow of mice CBA. In old animals the rhythmical disturbances of the indices were characterized by loss of fluctuations (Mac 1+-cells), increase of CD4+-cells amplitude, displacement of seasonal acrophase (CFC-F), inversion of rhythm (CFC-GM), desynchronization. In old mice after epithalamin injections the season differences between the amount of Mac-1+-cells restored, CD4+-cells amplitude diminished, the amount of CFC-GM increased in spring and CFC-F diminished in autumn. The influence of epithalon on CFC-F and CFG-GM rhythm was in a smaller dose. The rhythms of some indices in old animals showed a pattern observed in adults. After melatonin injections to adult mice in winter the amount of CD4+-cells increased; the ratio CFC-GM and CFC-F changed because of increase of stromal fibroblasts. In old mice the indices were without changes.
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D000375:Aging / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology*; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000378:metabolism / Q000502:physiology*; D012621:Seasons
D009842:Oligopeptides; D010455:Peptides; C027437:epithalamin; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine