Treatment of akinetic mutism with intramuscular olanzapine: a case series.
Akinetic mutism is a wakeful state of severe apathy and paucity of volitional movement. Evidence indicates a possible dopaminergic hypofunction within the anterior cingulate cortex. The authors present three cases of acute onset akinetic mutism successfully treated with intramuscular olanzapine.
Spiegel
David R
DR
Eastern Virginia Medical School, Department of Psychiatry and Behavior Sciences, 825 Fairfax Ave., Norfolk, VA 23507, USA. spiegedr@evms.edu
Casella
Daniel P
DP
Callender
David M
DM
Dhadwal
Neetu
N
D000368:Aged; D000405:Akinetic Mutism / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001569:Benzodiazepines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000379:methods; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine