Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones.
A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human fibroblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC(50) 1.3-89.5 microM, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety.
Valderrama
Jaime A
JA
Facultad de Quimica, Pontificia Universidad Católica de Chile, Casilla 306, Vicuna Machenna, 4860 Santiago, Chile. jvalderr@uc.cl
Leiva
Hilda
H
Rodríguez
Jaime A
JA
Theoduloz
Cristina
C
Schmeda-Hirshmann
Guillermo
G
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013329:Structure-Activity Relationship
D009285:Naphthoquinones; D011092:Polyethylene Glycols