Effects of extended-release felodipine on endothelial vasoactive substances in patients with essential hypertension.
BACKGROUND
Endothelial dysfunction plays a significant role in the pathogenesis of essential hypertension (EH). This trial was undertaken to reveal the effects of extended-release felodipine on endothelial vasoactive substances in EH patients.


METHODS
A colorimetric chemical method was employed to measure the level of nitric oxide (NO) and nitric oxide synthase (NOS), while radioimmunoassay was employed to measure endothelin (ET), angiotensin-II (Ang-II), thromboxane A2 (TXA(2)) and prostacyclin I(2) (PGI(2)) in plasma of the subjects. Group 1 consisted of 120 patients who were treated with a 4-week mono-therapy of felodipine. Group 2 consisted of 70 patients who were participating in fitness programs during this period. Another group comprising 80 individuals was selected as controls. Data from both the starting point and the ending point were collected and analyzed.


RESULTS
After a 4-week mono-therapy of extended-release felodipine in Group 1, the levels of plasma ET, Ang-II and TXA(2) decreased significantly, while levels of NO, NOS and PGI(2) did not noticeably change. In Group 2, there were almost no changes in levels of ET, Ang-II, TXA(2), NO, NOS and PGI(2).


CONCLUSIONS
From these results, we conclude that felodipine reduced blood pressure by decreasing the secretion of ET, Ang-II and TXA(2). Consequently, felodipine can revitalize the endothelial function in EH patients.
Song
Hui
H
Department of Medicine, Clinical Medical College of Shandong University, Jinan, Shandong, China.
Bao
Weiguo
W
Wang
Haibin
H
An
Guipeng
G
Feng
Jinbo
J
Wang
Rong
R
Zhang
Yun
Y
An
Fengshuang
F
D000804:Angiotensin II / Q000378:metabolism; D003124:Colorimetry; D003692:Delayed-Action Preparations / Q000494:pharmacology*; D016232:Endothelins / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism; D015736:Felodipine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism
D003692:Delayed-Action Preparations; D016232:Endothelins; D000804:Angiotensin II; D009569:Nitric Oxide; D011464:Epoprostenol; D019001:Nitric Oxide Synthase; D015736:Felodipine