Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum.
Usimines A-C ( 1- 3), three new usnic acid derivatives, have been isolated from a MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of 1- 3 were determined by analysis of their spectroscopic data (NMR, UV, MS) and by chemical methods. The known compound usnic acid ( 4) was also obtained. Compounds 1- 4 showed moderate inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B).
Seo
Changon
C
College of Medical and Life Sciences, Silla University, Busan 617-736, Korea.
Sohn
Jae Hak
JH
Park
Seong Min
SM
Yim
Joung Han
JH
Lee
Hong Kum
HK
Oh
Hyuncheol
H
D000864:Antarctic Regions; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*
D001572:Benzofurans; C529411:usimine A; C529412:usimine B; C529413:usimine C; C073339:usnic acid; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1