title: A novel polycationic analogue of gratisin with antibiotic activity against both Gram-positive and Gram-negative bacteria.
abstract: A novel polycationic analogue of gratisin, cyclo(-Val-Orn-Leu-D-Phe-Pro-D-Lys-)2, was designed and synthesized, which exhibited strong activity against all Gram-positive and Gram-negative bacteria tested. Its activity against Pseudomonas aeruginosa IFO 3080 was two times higher than gramicidin S.
authors.affiliation: Department of Chemistry, Toho University, Funabashi, Chiba, Japan. tamaki@chem.sci.toho-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Tamaki
authors.forename: Manabu
authors.initials: M
authors.lastname: Kokuno
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Iwama
authors.forename: Mitsuno
authors.initials: M
authors.lastname: Shindo
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002942:Circular Dichroism; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D010456:Peptides, Cyclic; C529284:cyclo(valyl-ornithyl-leucyl-phenylalanyl-prolyl-lysyl)2; C033282:gratisin