title: Association of the asporin D14 allele with lumbar-disc degeneration in Asians.
abstract: Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
authors.affiliation: Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: You-Qiang
authors.initials: YQ
authors.lastname: Song
authors.forename: Kenneth M C
authors.initials: KM
authors.lastname: Cheung
authors.forename: Daniel W H
authors.initials: DW
authors.lastname: Ho
authors.forename: Sandy C S
authors.initials: SC
authors.lastname: Poon
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chiba
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hirose
authors.forename: Mauro
authors.initials: M
authors.lastname: Alini
authors.forename: Sibylle
authors.initials: S
authors.lastname: Grad
authors.forename: Anita F Y
authors.initials: AF
authors.lastname: Yee
authors.forename: John C Y
authors.initials: JC
authors.lastname: Leong
authors.forename: Keith D K
authors.initials: KD
authors.lastname: Luk
authors.forename: Shea-Ping
authors.initials: SP
authors.lastname: Yip
authors.forename: Jaro
authors.initials: J
authors.lastname: Karppinen
authors.forename: Kathryn S E
authors.initials: KS
authors.lastname: Cheah
authors.forename: Pak
authors.initials: P
authors.lastname: Sham
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
authors.forename: Danny
authors.initials: D
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001224:Aspartic Acid / Q000737:chemistry / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007403:Intervertebral Disc; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics; D010007:Osteochondritis / Q000235:genetics*; D011110:Polymorphism, Genetic; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics
chemical_list: C439889:ASPN protein, human; D016326:Extracellular Matrix Proteins; D001224:Aspartic Acid