Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.
OBJECTIVE
To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence.


METHODS
Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months).


RESULTS
Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence (P<0.05). The Cox multivariate analysis indicated the nucleophosmin/B23 expression as an independent indicator for tumor recurrence (P=0.009).


CONCLUSIONS
The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence.
Tsui
Ke-hung
KH
Chang Gung Bioinformatics Center, Department of Urology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kwei-Shan, Taiwan, China.
Juang
Horng-heng
HH
Lee
Tsong-hai
TH
Chang
Phei-lang
PL
Chen
Chien-lun
CL
Yung
Benjamin Yat-ming
BY
D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology / Q000601:surgery; D015653:Cystectomy; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D000090243:Nucleophosmin; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D012044:Regression Analysis; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery
C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D012333:RNA, Messenger; D000090243:Nucleophosmin