title: Integrin-dependent translational control: Implication in cancer progression.
abstract: The importance of translational control in cancer progression has been underscored by a number of recent studies. However, little is known how cancer cells maintain their high efficiency of translation. Here, we summarize studies that support the role of integrins in translational control, especially at the initiation step, and discuss the various mechanisms by which integrins regulate the recruitment of translational machinery. This review also examines the hypothesis that integrins contribute to various aspects of cancer progression such as proliferation, survival, angiogenesis, and invasion through translational control.
authors.affiliation: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. jchung@lsuhsc.edu
authors.forename: Jun
authors.initials: J
authors.lastname: Chung
authors.forename: Tae Hyong
authors.initials: TH
authors.lastname: Kim
mesh_terms: D018450:Disease Progression; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D009385:Neoplastic Processes; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis
chemical_list: D015852:Eukaryotic Initiation Factor-2; D039561:Eukaryotic Initiation Factor-4E; D005353:Fibronectins; D016023:Integrins