[Study of long-term toxicity on applying Solanum lyratum on rat skin].
OBJECTIVE
To observe the long-term toxicity of rats which we had applied Solanum lyratum Thunb gel on their skins daily for 90 days.


METHODS
We had applied high and low doses of Solanum lyratum Thunb gel one time each day on healthy and punctured rats skins respectively for 90 days. The rats' characters were observed, and their blood routines, blood biochemistry index, anatomic and pathologic changes of their major organs were also detected.


RESULTS
Rats' characters had no change, the results of all detections were normal. There was no significant difference between test groups and control group. Rats'major organs had no change in anatomy and pathology.


CONCLUSIONS
No long-term toxic reaction can be found in the test of rats applied Solanum lyratum Thunb gel on their skins for a long term. It proves that it is safe using the normal dose of this gel on the skin in clinic.
Su
Xiang-yang
XY
Dermatology Department, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Qu
Cai-hong
CH
Zhang
Gan-yuan
GY
Lai
Wei
W
D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005782:Gels; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D032322:Solanum / Q000737:chemistry*; D036401:Toxicity Tests, Chronic
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D005782:Gels