The Salmonella-containing vacuole: moving with the times.
Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells. Following invasion the bacteria remain within a modified phagosome known as the Salmonella-containing vacuole (SCV), within which they will survive and replicate. Invasion and SCV biogenesis are dependent on two Type III secretion systems, T3SS1 and T3SS2, which are used to translocate distinct cohorts of bacterial effector proteins into the host cell. Elucidating the roles of individual effector proteins in SCV biogenesis has proven difficult but several distinct themes are now emerging and it is apparent that SCV biogenesis is an extremely dynamic process involving; extensive membrane remodeling, interactions with the endolysosomal pathway, actin rearrangements and microtubule-based movement and tubule extension.
Steele-Mortimer
Olivia
O
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA. omortimer@niaid.nih.gov
D000199:Actins / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D021381:Protein Transport; D019779:Salmonella enterica / Q000502:physiology*; D014617:Vacuoles / Q000382:microbiology*; D037521:Virulence Factors / Q000378:metabolism*
D000199:Actins; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D037521:Virulence Factors