title: REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease.
abstract: We report a case of a 68-year-old man with probable Alzheimer's disease who developed rapid eye movement (REM) sleep behaviour disorder. This was confirmed with polysomnography but the patient also had some sleep apnea, which prevented the use of clonazepam for treatment. Melatonin was successfully used as an alternative treatment.
authors.affiliation: Respiratory Support and Sleep Centre, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, United Kingdom. kirstieanderson@nhs.net
authors.forename: Kirstie N
authors.initials: KN
authors.lastname: Anderson
authors.forename: Sarah
authors.initials: S
authors.lastname: Jamieson
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Graham
authors.forename: John M
authors.initials: JM
authors.lastname: Shneerson
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D003937:Diagnosis, Differential; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D006728:Hormones; D008550:Melatonin