Composition, and anti-inflammatory and antioxidant activities of the volatile oil from the fruit peel of Garcinia brasiliensis.
The composition of the volatile oil obtained by hydrodistillation from the fruit peel of Garcinia brasiliensis (Mart.) Planch. et Triana was determined by GC/MS. A total of 38 components were identified, including gamma-muurolene (10.3%), spathulenol (8.7%), delta-cadinene (8.3%), torreyol (8.0%), alpha-cadinol (7.0%), cadalene (6.3%), and gamma-cadinene (5.3%). Oxygenated sesquiterpenes (43%) were the main group of compounds. The anti-inflammatory activity of the volatile oil was evaluated through the rat-paw edema model induced by carrageenan. Inhibition of the inflammatory process was noticed 3 h after carrageenan administration. In addition, the volatile oil showed poor antioxidant activity.
Martins
Felipe T
FT
Laboratório de Cristalografia, Departamento de Ciências Exatas, Universidade Federal de Alfenas - UNIFAL-MG, Rua Gabriel Monteiro da Silva, 714, Alfenas - MG, 37130-000, Brazil. felipetmartins@yahoo.com.br
Doriguetto
Antônio C
AC
de Souza
Thiago C
TC
de Souza
Kamila R D
KR
Dos Santos
Marcelo H
MH
Moreira
Maria E C
ME
Barbosa
Luiz C A
LC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002351:Carrageenan / Q000008:administration & dosage; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D029760:Garcinia / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes; D002351:Carrageenan