title: [Studies on hydrolysis of aconitine].
abstract: OBJECTIVE
  To find out hydrolysis regularity of aconitine.
  
  
  METHODS
  Aconitine was air-tighted and hydrolyzed in water for 8, 12, 16, 20, 24 h. The hydrolysis products were analyzed by HPLC-MS. A major hydrolysis product was isolated by alumina oxide column chromatography, and identified by 1H and 13C-NMR spectra.
  
  
  RESULTS
  HPLC-MS analysis shows that the major hydrolysis products are benzoylaconine and aconine. The hydrolysis can mostly be completed within 20 hours.
  
  
  CONCLUSIONS
  Diester aconitum alkaloid can be changed to monoester aconitum and aconine alkaloids. Under the controled condition benzoylaconine is a major hydrolysis products.
authors.affiliation: Chemistry Department of Wannan Medical College, Wuhu 241001, China. hqaa128@sohu.com
authors.forename: Qin-An
authors.initials: QA
authors.lastname: Huang
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Lin
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006868:Hydrolysis; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; C047307:benzoylaconine; C047306:aconine; D000157:Aconitine