The impact of acupuncture on in vitro fertilization outcome.
OBJECTIVE
To replicate previous research on the efficacy of acupuncture in increasing pregnancy rates (PR) in patients undergoing IVF and to determine whether such an increase was due to a placebo effect.


METHODS
Prospective, randomized, controlled, single blind trial.


METHODS
Private, academically affiliated, infertility clinic.


METHODS
One hundred fifty patients scheduled to undergo embryo transfer.


METHODS
Subjects were randomized to either the acupuncture or control group. Acupuncture patients received the protocol, as first described by Paulus and his colleagues, for 25 minutes before and after embryo transfer. Control subjects laid quietly. All subjects then completed questionnaires on anxiety and optimism. The IVF staff remained blind to subject assignment.


METHODS
Clinical PRs, anxiety, optimism.


RESULTS
Before randomization both groups had similar demographic characteristics including age and psychological variables. There were no significant differences in PRs between the two groups. Acupuncture patients reported significantly less anxiety post-transfer and reported feeling more optimistic about their cycle and enjoyed their sessions more than the control subjects.


CONCLUSIONS
The use of acupuncture in patients undergoing IVF was not associated with an increase in PRs but they were more relaxed and more optimistic.
Domar
Alice D
AD
Boston IVF, Inc., Waltham, Massachusetts 02451, USA.
Meshay
Irene
I
Kelliher
Joseph
J
Alper
Michael
M
Powers
R Douglas
RD
D015670:Acupuncture Therapy; D000328:Adult; D001007:Anxiety / Q000209:etiology / Q000517:prevention & control; D004311:Double-Blind Method; D004624:Embryo Transfer; D004644:Emotions; D005260:Female; D005307:Fertilization in Vitro / Q000523:psychology; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome