Familial aggregation in patients with non-alcoholic steatohepatitis.
We encountered three families that showed NASH accumulation. In family #1, a 21-year-old son and 10-year-old daughter were diagnosed with nonalcoholic steatohepatitis (NASH). They shared two adiponectin-gene single nucleotide polymorphisms (SNP). In family #2, a 51-year-old mother and 27-year-old son were diagnosed with NASH and shared the SNPs of other genes. In family #3, a 66-year-old mother and 34-year-old son were diagnosed with NASH and shared the SNPs of other genes. SNP sites differed among the three families, suggesting that the genes associated with the occurrence of NASH might be different in each patient.
Tokushige
Katsutoshi
K
Department of Medicine and Gastroenterology, Tokyo Women's Medical University. ktoku@pg7.so-net.ne.jp <ktoku@pg7.so-net.ne.jp>
Yatsuji
Satoru
S
Hashimoto
Etsuko
E
Kabutake
Ayae
A
Tobari
Maki
M
Taniai
Makiko
M
Shiratori
Keiko
K
D052242:Adiponectin / Q000235:genetics; D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000235:genetics; D002648:Child; D005234:Fatty Liver / Q000178:diet therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
C499918:ADIPOQ protein, human; D052242:Adiponectin; D002352:Carrier Proteins; D022702:Receptors, Adrenergic, beta-3; D014409:Tumor Necrosis Factor-alpha; C106092:microsomal triglyceride transfer protein; D013482:Superoxide Dismutase