Apraxia of eyelid opening after subthalamic deep brain stimulation may be caused by reduction of levodopa.
Apraxia of eyelid opening (ALO) is an infrequent side effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD). However, the pathogenesis of ALO after STN DBS is not well understood. We report on two patients who suffered from disabling ALO after bilateral STN DBS. Their ALO improved by resuming the levodopa medication that had been discontinued after the surgery. Although ALO after STN DBS is considered as an adverse effect of STN stimulation, postoperative modification of dopaminergic medication may be a cause of ALO after STN DBS.
Umemura
Atsushi
A
Department of Neurosurgery, Nagoya City University Medical School, 1 Kawasumi, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. aume@med.nagoya-cu.ac.jp
Toyoda
Takanari
T
Yamamoto
Kenichi
K
Oka
Yuichi
Y
Ishii
Fumiyasu
F
Yamada
Kazuo
K
D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001072:Apraxias / Q000188:drug therapy* / Q000209:etiology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005143:Eyelids / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology
D000978:Antiparkinson Agents; D007980:Levodopa