title: Poor postoperative blood glucose control increases surgical site infections after surgery for hepato-biliary-pancreatic cancer: a prospective study in a high-volume institute in Japan.
abstract: Two hundred and sixty-five consecutive patients awaiting hepato-biliary-pancreatic surgery were prospectively observed for surgical site infections (SSIs). SSI rates differed according to type of hepato-biliary-pancreatic surgery. Multivariate analysis identified enteric anastomoses, poor postoperative blood glucose control and type of cancer as independent risk factors. SSI rates were directly correlated with the degree of hyperglycaemia encountered during the postoperative period. In particular, SSI rates were 5/25 (20%) among patients in whom a blood glucose level of <200mg/dL was maintained by insulin infusion therapy, which was significantly better than the rates of 49/94 (52%) among patients in whom a blood glucose level of <200mg/dL was not maintained despite insulin infusion therapy (P<0.01). It is necessary to maintain postoperative blood glucose levels of <200mg/dL in order to reduce SSI rates.
authors.affiliation: Surgical Centre, Chiba University Hospital, 1-8-1 Inohana, Chiba 260-8677, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ambiru
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: F
authors.initials: F
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Yoshidome
authors.forename: M
authors.initials: M
authors.lastname: Otsuka
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D001661:Biliary Tract Neoplasms / Q000601:surgery*; D001786:Blood Glucose / Q000187:drug effects*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin