Hepatocellular carcinoma and occupation in men: a case-control study.
OBJECTIVE
The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations.


METHODS
This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects.


RESULTS
An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0-19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8-5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years.


CONCLUSIONS
Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.
Ferrand
Jean-François
JF
Inserm Unité 754-IFR 69, Villejuif, France.
Cénée
Sylvie
S
Laurent-Puig
Pierre
P
Loriot
Marie-Anne
MA
Trinchet
Jean Claude
JC
Degos
Françoise
F
Bronovicky
Jean-Pierre
JP
Pelletier
Gilles
G
Stücker
Isabelle
I
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000453:epidemiology*; D016022:Case-Control Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007407:Interviews as Topic; D008113:Liver Neoplasms / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations / Q000145:classification*; D012307:Risk Factors; D013997:Time Factors