Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients.
To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy (HE). S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE.
Saleh
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A
Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt. azzasaleh@hotmail.com
Kamel
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L
Ghali
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Ismail
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A
El Khayat
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H
D000641:Ammonia / Q000097:blood; D000704:Analysis of Variance; D001253:Astrocytes / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D004534:Egypt / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D015985:Precipitating Factors; D015995:Prevalence; D012372:ROC Curve; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014504:Urban Health
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D000641:Ammonia; D010751:Phosphopyruvate Hydratase