title: Prenylated flavonoid derivatives from the bark of Erythrina addisoniae.
abstract: Two new prenylated flavanones, 2 S-3'-(2-hydroxy-3-methylbut-3-enyl)licoflavone-4'-methyl ether ( 3) and 2 S-3'-(2-hydroxy-3-methylbut-3-enyl)abyssinone II ( 4), and four known flavanones ( 1, 2, 5, 6) were isolated from the stem bark of Erythrina addisoniae. The structures were elucidated on the basis of their spectroscopic and physicochemical data. None of the compounds showed antioxidative properties. 4'-Methylabyssinone V ( 1) and abyssinoflavanone VII ( 6) showed moderate cytotoxic activity (IC 50 = 5 and 3.5 micromol/L, respectively), but apoptosis (caspase-3/7-activation, nuclear fragmentation) was selectively induced by abyssinoflavanone VII ( 6).
authors.affiliation: Institute of Toxicology, Heinrich-Heine-University, P.O. Box 101007, 40001 Düsseldorf, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Wätjen
authors.forename: A K
authors.initials: AK
authors.lastname: Suckow-Schnitker
authors.forename: R
authors.initials: R
authors.lastname: Rohrig
authors.forename: A
authors.initials: A
authors.lastname: Kulawik
authors.forename: J
authors.initials: J
authors.lastname: Addae-Kyereme
authors.forename: C W
authors.initials: CW
authors.lastname: Wright
authors.forename: C M
authors.initials: CM
authors.lastname: Passreiter
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004895:Erythrina / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D051381:Rats
chemical_list: D044950:Flavanones