A comparative study of bimatoprost and travoprost: effect on intraocular pressure and ocular circulation in newly diagnosed glaucoma patients.
BACKGROUND
This study compares intraocular pressure (IOP)-lowering efficacy and retrobulbar hemodynamic effects of bimatoprost and travoprost in patients with newly diagnosed open-angle glaucoma.


METHODS
Patients were randomly assigned to one of two treatment groups (bimatoprost group, n = 36; travoprost group, n = 46). IOP levels were measured with Goldmann applanation tonometer. Peak systolic velocity, end-diastolic velocity and resistivity index were obtained for each vessel by color Doppler imaging.


RESULTS
Both bimatoprost and travoprost significantly lowered IOP on days 30, 90 and 180 (p < 0.001). There was no significance between the 2 drugs on all follow-up visits. End-diastolic velocity of central retinal artery on day 180 was significantly higher than the value obtained at baseline in both groups.


CONCLUSIONS
Patients were likely to achieve and maintain low target IOP with both drugs. Both drugs also resulted in improvement in the central retinal artery blood flow.
Alagoz
Gürsoy
G
Department of Ophthalmology, Medical Faculty, Abant Izzet Baysal University, Bolu, Turkey. gursoyalagoz@hotmail.com
Gürel
Kamil
K
Bayer
Atilla
A
Serin
Didem
D
Celebi
Serdal
S
Kukner
Sahap
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000577:Amides / Q000627:therapeutic use*; D000069580:Bimatoprost; D001783:Blood Flow Velocity / Q000187:drug effects; D003008:Cloprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003971:Diastole; D005123:Eye / Q000098:blood supply*; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008055:Lipids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D012161:Retinal Artery / Q000503:physiopathology; D013997:Time Factors; D000069557:Travoprost; D018615:Ultrasonography, Doppler, Color
D000577:Amides; D008055:Lipids; D003008:Cloprostenol; D000069580:Bimatoprost; D000069557:Travoprost