Protein tyrosine phosphatases: regulatory mechanisms.
Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
den Hertog
Jeroen
J
Hubrecht Institute, Utrecht, the Netherlands. j.denhertog@niob.knaw.nl
Ostman
Arne
A
Böhmer
Frank-D
FD
D017398:Alternative Splicing; D000818:Animals; D019281:Dimerization; D006801:Humans; D008024:Ligands; D010084:Oxidation-Reduction; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017027:Protein Tyrosine Phosphatases / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*
D008024:Ligands; D017027:Protein Tyrosine Phosphatases