A cautionary tale: anaphylaxis to isosulfan blue dye after 12 years and 3339 cases of lymphatic mapping.
Sentinel node biopsy has become the standard method for lymphatic staging in early-stage breast cancer and melanomas. The most commonly used technique uses both a radioactive tracer as well as blue dye, usually isosulfan blue. In this report, we discuss two episodes of anaphylaxis to isosulfan blue during lymphatic mapping, occurring 12 years and 3339 lymphatic mapping cases after adoption of the technique, and discuss management issues raised by these events.
Kaufman
Gabriel
G
Division of Surgical Oncology, Department of Surgery, New York University School of Medicine, New York, NY 10016, USA.
Guth
Amber A
AA
Pachter
H Leon
HL
Roses
Daniel F
DF
D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D004396:Coloring Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012394:Rosaniline Dyes / Q000009:adverse effects*; D021701:Sentinel Lymph Node Biopsy / Q000379:methods* / Q000706:statistics & numerical data; D013997:Time Factors
D004396:Coloring Agents; D012394:Rosaniline Dyes; C025484:iso-sulfan blue