[Study on the characteristics of content and distribution of light rare earth elements in rat testes].
OBJECTIVE
To study the characteristics of content and distribution of light Rare Earth Elements (LREEs) in rat testes.


METHODS
Based on animal weight, 60 healthy male SD rats were randomly divided into two control groups and four experimental groups. After four week treat, the testes were collected except High-II . The High- II group was freely fed for another four week without the Citrate REEs. The LREE concentrations in the testes were determined by the inductively coupled plasma mass spectrometer (ICP-MS).


RESULTS
(1) The concentrations of LREEs in testes increased with the increase of the doses. The concentrations of LREEs of High-II were much lower than those of High-I significantly (P < 0.05). (2) The distribution patterns of La, Ce, Pr in the testes approximated to the Odd Harkin's rule, but the Nd was an exception (negative deviation). 3. The correlation coefficients of LREEs concentrations between hair and testis were about 0.4, while those between blood and testis were much lower and have no significance.


CONCLUSIONS
(1) Dose response relationship could exist in the accumulation of LREEs in the rat testes. (2) Testis could have its own distribution pattern of LREEs. (3) The accumulation of LREEs in testis could be reversible. (4) As it was, a biomarker of the LREEs in hair could be much better than that of blood.
Liu
Jingxiu
J
School of Public Health, Peking University, Beijing 100083, China. xiugeer@yahoo.com.cn
Wang
Xiaoyan
X
Xie
Qing
Q
Liu
Yang
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006197:Hair / Q000737:chemistry*; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008674:Metals, Rare Earth / Q000032:analysis / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000737:chemistry* / Q000378:metabolism; D014018:Tissue Distribution
D008674:Metals, Rare Earth