title: Recurrent pure mucinous carcinoma of the breast with mediastinal great vessel invasion: HER-2/neu confers aggressiveness.
abstract: Mucinous carcinoma of the breast, also known as colloid carcinoma, is a less common variant of breast cancer constituting less than five per cent of breast cancers. We report the case of a 42-year-old premenopausal female who presented with a palpable chest wall recurrence 4 years after simple mastectomy, axillary node dissection, and TRAM flap reconstruction for pure mucinous carcinoma. The recurrent neoplasm was a pure mucinous carcinoma and was found to be invading the mediastinum into the great vessels. The tumor was estrogen receptor positive, progesterone receptor negative, and HER-2/neu positive, which is an unusual finding for mucinous carcinoma. The fact that this tumor demonstrated HER-2/neu positivity may explain the uncharacteristic aggressive nature of this normally indolent type of breast tumor. To our knowledge, this is the first reported case of any mucinous breast cancer invading the mediastinal great vessels and its subsequent en-bloc resection.
authors.affiliation: St. Joseph Mercy Oakland Hospital, Pontiac, Michigan 48341, USA.
authors.forename: Jamie D
authors.initials: JD
authors.lastname: Adair
authors.forename: Kyle P
authors.initials: KP
authors.lastname: Harvey
authors.forename: Ali
authors.initials: A
authors.lastname: Mahmood
authors.forename: James
authors.initials: J
authors.lastname: Caralis
authors.forename: William
authors.initials: W
authors.lastname: Gordon
authors.forename: Gregory
authors.initials: G
authors.lastname: Yanish
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000328:Adult; D016121:Brachiocephalic Veins; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018734:Genes, erbB-2 / Q000502:physiology; D006801:Humans; D008482:Mediastinum; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D019043:Vascular Neoplasms / Q000235:genetics / Q000473:pathology*; D014683:Vena Cava, Superior