Serotonin transporter gene polymorphisms: effect on serotonin transporter availability in the brain of suicide attempters.
The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using (123)I-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.
Bah
Jessica
J
Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Sweden. jessica.bah@pharm.gu.se
Lindström
Mats
M
Westberg
Lars
L
Mannerås
Louise
L
Ryding
Erik
E
Henningsson
Susanne
S
Melke
Jonas
J
Rosén
Ingmar
I
Träskman-Bendz
Lil
L
Eriksson
Elias
E
D000328:Adult; D000483:Alleles; D001921:Brain / Q000378:metabolism*; D015870:Gene Expression / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic; D016728:Self-Injurious Behavior / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*; D015899:Tomography, Emission-Computed, Single-Photon
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins