title: Inflammatory marker but not adipokine predicts mortality among long-term hemodialysis patients.
abstract: OBJECTIVE
  chronic inflammation contributes significantly to the morbidity and mortality of chronic hemodialysis patients. A recent research has shown that adipokines were associated with inflammation in these patients. We aim to investigate whether biomarkers of inflammation, adipokines, and clinical features can predict the outcome of hemodialysis patients.
  
  
  METHODS
  we enrolled 181 hemodialysis patients (men: 97, mean age: 56.3+/-13.6) and analyzed predictors of long-term outcomes.
  
  
  RESULTS
  during the 3-year followup period, 41 patients died; the main causes of death were infection and cardiovascular disease. Elevated serum levels of hsCRP and albumin and advanced age were highly associated with death (all P<.001). Leptin and adiponectin levels were not significantly different between deceased patients and survivors. Cox-regression analysis indicated that age, diabetes, albumin level, and hsCRP were independent factors predicting mortality.
  
  
  CONCLUSIONS
  the presence of underlying disease, advanced age, and markers of chronic inflammation is strongly related to survival rate in long-term hemodialysis patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung Hsien 833, Taiwan.
authors.forename: Yu-Che
authors.initials: YC
authors.lastname: Tsai
authors.forename: Chien-Te
authors.initials: CT
authors.lastname: Lee
authors.forename: Tiao-Lai
authors.initials: TL
authors.lastname: Huang
authors.forename: Ben-Chung
authors.initials: BC
authors.lastname: Cheng
authors.forename: Chien-Chun
authors.initials: CC
authors.lastname: Kuo
authors.forename: Yih
authors.initials: Y
authors.lastname: Su
authors.forename: Hwee-Yeong
authors.initials: HY
authors.lastname: Ng
authors.forename: Chih-Chau
authors.initials: CC
authors.lastname: Yang
authors.forename: Fong-Rong
authors.initials: FR
authors.lastname: Chuang
authors.forename: Shang-Chih
authors.initials: SC
authors.lastname: Liao
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D054392:Adipokines; D015415:Biomarkers