Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle.
The aim of this study was to determine whether single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle. By direct DNA sequencing in 24 unrelated Korean native cattle, we identified 20 SNPs in FABP3 and FABP4. Among them, 10 polymorphic sites were selected for genotyping in our beef cattle. We performed SNP, haplotype and linkage disequilibrium studies on 419 Korean native cattle with the 10 SNPs in the FABP genes. Statistical analysis revealed that 220AG (I74V) and 348+303TC polymorphisms in FABP4 showed putative associations with BF traits (P=0.02 and 0.01, respectively). Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence BF in beef cattle.
Cho
Seoae
S
Laboratory of Bioinformatics and Biostatistics, Interdisciplinary Program in Bioinformatics, Department of Statistics, Seoul National University, Seoul, Korea.
Park
Tae Sung
TS
Yoon
Du-Hak
DH
Cheong
Hyun Sub
HS
Namgoong
Sohg
S
Park
Byung Lae
BL
Lee
Hye Won
HW
Han
Chang Soo
CS
Kim
Eun Mi
EM
Cheong
Il-Cheong
IC
Kim
Heebal
H
Shin
Hyoung Doo
HD
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D001835:Body Weight / Q000235:genetics; D002417:Cattle; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D007723:Korea; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D050556:Fatty Acid-Binding Proteins