title: [Treatment of antiphospholipid syndrome].
abstract: The antiphospholipid syndrome (APS) is a disorder of recurrent thrombosis and/or pregnancy loss associated with the presence of antiphospholipid antibodies and persistently positive lupus anticoagulant, anticardiolipin or anti beta2-glycoprotein1. Oral anticoagulants are the best available and most effective treatment for the secondary prevention of recurrent venous or arterial thrombosis. Patients with APS are treated with long-term therapy to prolong the INR to 2.0-3.0. Low-molecular-weight heparin in combination with low-aspirin dose is a reasonable strategy to avoid pregnancy loss in women with this syndrome.
authors.affiliation: Servicio de Hematología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona. japaramo@unav.es
authors.forename: J A
authors.initials: JA
authors.lastname: Páramo
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Panizo
authors.forename: R
authors.initials: R
authors.lastname: Lecumberri
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D016736:Antiphospholipid Syndrome / Q000188:drug therapy*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight