title: The inflammatory radicular cysts have higher concentration of tnf-alpha in comparison to odontogenic keratocysts (odontogenic tumour).
abstract: TNF-alpha is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-alpha in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-alpha is elevated in both cysts' fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-alpha was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p < 0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-alpha. We here for the first time present that a difference in the concentration of TNF-alpha exists between these two cystic types.
authors.affiliation: University of Kragujevac, School of Medicine, Kragujevc, Serbia. vdvd@mailcity.com
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jurisic
authors.forename: Snjezana
authors.initials: S
authors.lastname: Colic
authors.forename: Milan
authors.initials: M
authors.lastname: Jurisic
mesh_terms: D020420:Cyst Fluid / Q000737:chemistry; D006801:Humans; D009807:Odontogenic Cysts / Q000737:chemistry*; D011842:Radicular Cyst / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D014409:Tumor Necrosis Factor-alpha