Impact of anti-tuberculosis therapy on plasma zinc status in childhood tuberculosis.
This study compared plasma zinc levels in 15 children with active pulmonary tuberculosis, 15 malnourished children and 15 healthy children. Mean plasma zinc concentrations in children with tuberculosis (71.7 microg/dL) were not significantly different than the other 2 groups (72.5 and 76.9 microg/dL). The zinc status of the children with tuberculosis was evaluated after 2 months and 4 months of DOTS therapy. The serum zinc level during anti-tuberculosis therapy decreased after 1 month and then recovered to the initial level after 4 months of treatment.
Boloorsaz
M R
MR
National Research Institute of Tuberculosis and Lung Disease, Massih Daneshvari Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Khalilzadeh
S
S
Milanifar
A R
AR
Safavi
A
A
Velayati
A A
AA
D000995:Antitubercular Agents / Q000009:adverse effects*; D001798:Blood Proteins / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D015362:Child Nutrition Disorders / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D002675:Child, Preschool; D023801:Directly Observed Therapy / Q000009:adverse effects; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007223:Infant; D007492:Iran; D008297:Male; D015596:Nutrition Assessment; D009752:Nutritional Status; D012709:Serum Albumin / Q000378:metabolism; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*; D015032:Zinc / Q000097:blood / Q000172:deficiency
D000995:Antitubercular Agents; D001798:Blood Proteins; D012709:Serum Albumin; D015032:Zinc