title: Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum.
authors.forename: Sanja
authors.initials: S
authors.lastname: Kezic
authors.forename: Patrick M J H
authors.initials: PM
authors.lastname: Kemperman
authors.forename: Ellen S
authors.initials: ES
authors.lastname: Koster
authors.forename: Cindy M
authors.initials: CM
authors.lastname: de Jongh
authors.forename: Hok Bing
authors.initials: HB
authors.lastname: Thio
authors.forename: Linda E
authors.initials: LE
authors.lastname: Campbell
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
authors.forename: W H Irwin
authors.initials: WH
authors.lastname: McLean
authors.forename: Irwin W H
authors.initials: IW
authors.lastname: McLean
authors.forename: Gerwin J
authors.initials: GJ
authors.lastname: Puppels
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Caspers
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000150:complications / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism*; D005260:Female; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D014870:Water Loss, Insensible / Q000235:genetics*
chemical_list: D015415:Biomarkers; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins