title: Chromatin organization and virus gene expression.
abstract: Many viruses introduce DNA into the host-cell nucleus, where they must either embrace or confront chromatin factors as a support or obstacle to completion of their life cycle. Compared to the eukaryotic cell, viruses have compact and rapidly evolving genomes. Despite their smaller size, viruses have complex life cycles that involve dynamic changes in DNA structure. Nuclear entry, transcription, replication, genome stabilization, and virion packaging involve complex changes in chromosome organization and structure. Chromatin dynamics and epigenetic modifications play major roles in viral and host chromosome biology. In some cases, viruses may use novel or viral-specific epigenetic modifying activities, which may reflect variant pathways that distinguish their behavior from the bulk of the cellular chromosome. This review examines several recent discoveries that highlight the role of chromatin dynamics in the life cycle of DNA viruses.
authors.affiliation: The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Lieberman
mesh_terms: D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D004267:DNA Viruses / Q000235:genetics* / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism; D044127:Epigenesis, Genetic; D015967:Gene Expression Regulation, Viral; D020868:Gene Silencing; D016679:Genome, Viral; D046911:Macromolecular Substances / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D004279:DNA, Viral; D046911:Macromolecular Substances; D014764:Viral Proteins