title: Duodenal mucosa-associated lymphoid tissue lymphoma: a case report.
abstract: Primary duodenal mucosa associated lymphoid tissue (MALT) lymphoma is very rare, and little is known about its clinical course or effective treatment. We describe a case of primary duodenal MALT lymphoma that was resistant to Helicobacter pylon (H. pylori) eradication and regressed after chemotherapy with cyclophosphamide, vincristine, and prednisolone (CVP). A 71-year-old woman was referred to our department because of epigastric pain and dyspepsia. Gastroduodenoscopy revealed an irregular mucosal nodular lesion with ulceration extending from the bulb to the second portion of the duodenum. Histopathological examination of a biopsy specimen disclosed low-grade MALT lymphoma composed of atypical lymphoid cells with lymphoepithelial lesion. Abdominal CT scans revealed 0.5 to 1.5 cm lymph nodes in the peritoneal cavity, suggestive of lymph node metastasis. We successfully eradicated H. pylori but did not see signs of remission. We administered systemic CVP chemotherapy every 3 weeks. After 6 courses of CVP, the patient achieved complete remission and was followed up without recurrence for about a year.
authors.affiliation: Department of Internal Medicine, Kangnam Sacred-heart Hospital, College of Medicine Hallym University, Seoul, Korea.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Woo
authors.forename: Jung Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Seong Bo
authors.initials: SB
authors.lastname: Yoon
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Jang
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Lee
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Hong
authors.forename: Il Hyun
authors.initials: IH
authors.lastname: Baek
mesh_terms: D000368:Aged; D024221:Antineoplastic Protocols; D003520:Cyclophosphamide; D004386:Duodenum / Q000473:pathology*; D005260:Female; D016481:Helicobacter Infections; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000473:pathology*; D011239:Prednisolone; D014750:Vincristine
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone