title: Preoperative peripheral naïve / memory ratio and prognosis of nonsmall-cell lung cancer patients.
abstract: OBJECTIVE
  This study focused on the relationship between preoperative peripheral blood CD4(+) naïve/memory ratio and prognosis following surgery for patients with nonsmall-cell lung cancer.
  
  
  METHODS
  After measuring CD3, CD4, CD8, CD45RA, CD45RO, CD25, and intracellular CTLA4 levels, CD4(+) naïve/memory ratios were determined for 13 controls and 38 patients.
  
  
  RESULTS
  Although we observed no significant difference in the ratios, the patients exhibited a wider range of values than the controls. Of the 38 patients, 24 subsequently underwent surgery and were divided into three groups based on their preoperative CD4(+) naïve/memory ratio: Group I: <0.3; Group II: 0.3-0.8; and Group III: >0.8. Survival times were then evaluated. Group II survival was significantly better than Groups I and III.
  
  
  CONCLUSIONS
  Our data suggest that the preoperative CD4(+) naïve/memory ratio may serve as a prognostic factor for nonsmall-cell lung cancer patients.
authors.affiliation: Department of Cardiovascular, University of Miyazaki, Miyazaki, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hara
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Matsuzaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shimizu
authors.forename: Masaki
authors.initials: M
authors.lastname: Tomita
authors.forename: Takanori
authors.initials: T
authors.lastname: Ayabe
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Enomoto
authors.forename: Toshio
authors.initials: T
authors.lastname: Onitsuka
mesh_terms: D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000401:mortality; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D017493:Leukocyte Common Antigens