title: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.
abstract: Some 40-odd genes in mammals encode phosphotyrosine-specific, 'classical' protein tyrosine phosphatases. The generation of animal model systems and the study of various human disease states have begun to elucidate the important and diverse roles of protein tyrosine phosphatases in cellular signalling pathways, development and disease. Here, we provide an overview of those findings from mice and men, and indicate several novel approaches that are now being exploited to further our knowledge of this fascinating enzyme family.
authors.affiliation: Department of Cell Biology, Radboud University Nijmegen Medical Centre, The Netherlands. w.hendriks@ncmls.ru.nl
authors.forename: Wiljan J A J
authors.initials: WJ
authors.lastname: Hendriks
authors.forename: Ari
authors.initials: A
authors.lastname: Elson
authors.forename: Sheila
authors.initials: S
authors.lastname: Harroch
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Stoker
mesh_terms: D000818:Animals; D004194:Disease / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000201:enzymology; D051379:Mice; D009857:Oncogenes; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000502:physiology*; D051381:Rats; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
chemical_list: D025521:Tumor Suppressor Proteins; D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases