Current topics in DNA double-strand break repair.
DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.
Kobayashi
Junya
J
Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan.
Iwabuchi
Kuniyoshi
K
Miyagawa
Kiyoshi
K
Sonoda
Eiichiro
E
Suzuki
Keiji
K
Takata
Minoru
M
Tauchi
Hiroshi
H
D018797:Cell Cycle Proteins / Q000502:physiology; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D004720:Endonucleases / Q000502:physiology; D006657:Histones / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D044763:Ubiquitin-Conjugating Enzymes / Q000502:physiology
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D006657:Histones; C112156:NBN protein, human; D009687:Nuclear Proteins; C478985:PDRG1 protein, human; C471607:UBE2N protein, human; D044763:Ubiquitin-Conjugating Enzymes; D004720:Endonucleases; C498772:MUS81 protein, human