Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure.
OBJECTIVE
To investigate the association of exposure to fine particulate matter (PM2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes.


METHODS
Forty-one workers were monitored over 24 hours during which baseline, postshift, bedtime, and next morning measurements were collected. Twenty-two workers participated as controls.


RESULTS
Linear regression was used to model pairwise change in u-8-isoprostane and u-8-OHdG: pre- to postshift, preshift to bedtime, postshift to bedtime, and postshift to next morning. In the models, pre- to postshift change in 8-OHdG was statistically significant, whereas postshift to bedtime change in 8-isoprostane showed an unexpected inverse relationship with PM2.5.


CONCLUSIONS
Acute welding exposure is associated with a postshift blunting of systemic inflammation in chronically exposed boilermakers, as measured by 8-isoprostane. The level of oxidative DNA damage as measured by 8-OHdG is less clear.
Nuernberg
Amy M
AM
Department of Environmental Health, Harvard School of Public Health, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Boyce
Paul D
PD
Cavallari
Jennifer M
JM
Fang
Shona C
SC
Eisen
Ellen A
EA
Christiani
David C
DC
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D016902:Air Pollution, Indoor / Q000009:adverse effects; D015415:Biomarkers / Q000652:urine; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D016014:Linear Models; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress; D052638:Particulate Matter / Q000652:urine; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry; D014896:Welding
D000395:Air Pollutants, Occupational; D015415:Biomarkers; D052638:Particulate Matter; C075750:8-epi-prostaglandin F2alpha; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine