title: Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
abstract: BACKGROUND
  The importance of oral health to systemic health and quality of life (QOL) is gaining attention. Although several studies have examined generic (general) QOL in Sjögren syndrome (SS), little information exists on the effect of oral health on QOL and relationships among self-reported oral health, systemic health and objective clinical measures of health. The authors conducted this study to characterize these relationships in a sample of patients with SS.
  
  
  METHODS
  Thirty-nine patients with a diagnosis of SS ascertained by means of the 2002 American-European Consensus criteria completed both the Oral Health Impact Profile (OHIP-14) and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) QOL questionnaires. OHIP-14 measures pain; functional limitation; and psychological, emotional and social disability associated with the mouth. SF-36 measures physical and emotional health and the ability to perform usual activities. Additional measures included the number of self-reported autoimmune symptoms and an index of disease damage. Statistical analysis was performed by using hierarchical regression analysis.
  
  
  RESULTS
  Both generic and oral health-related QOL were poor in these patients. Specifically, the findings indicated that salivary flow rate was correlated significantly with both Disease Damage Index and OHIP-14 ratings, the number of autoimmune symptoms was correlated significantly with both oral and generic QOL, and oral health accounted for a significant percentage of variance in SF-36 domains of general health and social function.
  
  
  CONCLUSIONS
  Oral health appears to have an independent influence on general QOL in patients with SS. These findings underscore the importance of proactive dental management of the oral manifestations of SS.
  
  
  CONCLUSIONS
  Dentists and physicians must work collaboratively to maintain oral health and quality of life for patients with Sjögren syndrome. The dentist should address patients' concerns of xerostomia and hyposalivation in an aggressive manner.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida, Gainesville 32610, USA. cstewart@dental.ufl.edu
authors.forename: Carol M
authors.initials: CM
authors.lastname: Stewart
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Berg
authors.forename: Seunghee
authors.initials: S
authors.lastname: Cha
authors.forename: Westley H
authors.initials: WH
authors.lastname: Reeves
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012044:Regression Analysis; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate; D018434:Sickness Impact Profile; D012859:Sjogren's Syndrome / Q000503:physiopathology* / Q000523:psychology*; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000503:physiopathology / Q000523:psychology