title: [Recent advances in the study of antifungal lead compounds with new chemical scaffolds].
abstract: In recent years, the incidence of infections caused by invasive fungal pathogens has increased dramatically. However, most antifungal agents used in clinic have many drawbacks and cannot meet the demand of the clinical use. Therefore, for the development of new generation of antifungal agents, it is of great significance to find antifungal lead compounds with novel chemical scaffolds and new mode of action. Novel antifungal lead compounds reported in recent years are reviewed. Their chemical structures, antifungal activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Lü-cheng
authors.initials: LC
authors.lastname: Shao
authors.forename: Chun-quan
authors.initials: CQ
authors.lastname: Sheng
authors.forename: Wan-nian
authors.initials: WN
authors.lastname: Zhang
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001599:Berberine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D002777:Cholestanols / Q000737:chemistry / Q000494:pharmacology; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D002777:Cholestanols; D006571:Heterocyclic Compounds; D007783:Lactones; D009285:Naphthoquinones; D011725:Pyridines; C101439:UK 2A; C094022:incrustoporin; D001599:Berberine; D003515:Cycloleucine; C065594:cispentacin; C079655:squalamine; D015107:4-Butyrolactone