Transient global amnesia associated with the infusion of DMSO-cryopreserved autologous peripheral blood stem cells.
Dimethylsulfoxide (DMSO) is a solvent commonly used for the cryopreservation of autologous peripheral blood stem cells (APBSC). Side effects upon infusion of DMSO-cryopreserved APBSC mainly consist of nausea, emesis, chills, rigors, and cardiovascular events, such as bradyarrhythmia or hypotension. We report the case of a patient who received DMSO-cryopreserved APBSC after myeloablative chemotherapy for a relapsing lymphoma. The patient developed a rare reaction during the infusion manifesting as transient global amnesia. The clinical course during the reaction is described and an explanation of the possible causes is discussed. This observation underlines the need for an adequate DMSO depletion to limit neurotoxicity or other adverse manifestations.
Otrock
Zaher K
ZK
Department of Pathology and Laboratory Medicine, American University of Beirut-Medical Center, PO Box 113-6044, Beirut, Lebanon.
Beydoun
Ahmad
A
Barada
Wissam M
WM
Masroujeh
Rami
R
Hourani
Rola
R
Bazarbachi
Ali
A
D000328:Adult; D000472:Alkalosis, Respiratory / Q000209:etiology / Q000503:physiopathology; D000648:Amnesia, Retrograde / Q000139:chemically induced / Q000209:etiology*; D020236:Amnesia, Transient Global / Q000139:chemically induced / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002330:Carmustine / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003221:Confusion / Q000139:chemically induced; D003451:Cryoprotective Agents / Q000633:toxicity*; D003561:Cytarabine / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004121:Dimethyl Sulfoxide / Q000633:toxicity*; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006624:Hippocampus / Q000473:pathology; D006689:Hodgkin Disease / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D006985:Hyperventilation / Q000150:complications / Q000503:physiopathology; D007069:Ifosfamide / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D010292:Paresthesia / Q000139:chemically induced; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D016879:Salvage Therapy; D014747:Vinblastine / Q000008:administration & dosage; D014786:Vision Disorders / Q000139:chemically induced
D003451:Cryoprotective Agents; D003561:Cytarabine; D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D003606:Dacarbazine; D003907:Dexamethasone; D004317:Doxorubicin; D002945:Cisplatin; D008558:Melphalan; D002330:Carmustine; D007069:Ifosfamide; D004121:Dimethyl Sulfoxide