title: Progress in the studies on rutaecarpine.
abstract: Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. Recent progress in the studies on the isolation, synthesis, structure-activity relationship studies, biological activities and metabolism of rutaecarpine are reviewed.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan 712-749 Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Byeong Seon
authors.initials: BS
authors.lastname: Jeong
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Jeong
authors.forename: Hyeon Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Eung-Seok
authors.initials: ES
authors.lastname: Lee
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
mesh_terms: D000818:Animals; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D052999:Quinazolinones
chemical_list: D026121:Indole Alkaloids; D011799:Quinazolines; C028632:rutecarpine; D052999:Quinazolinones