Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.
Some 40-odd genes in mammals encode phosphotyrosine-specific, 'classical' protein tyrosine phosphatases. The generation of animal model systems and the study of various human disease states have begun to elucidate the important and diverse roles of protein tyrosine phosphatases in cellular signalling pathways, development and disease. Here, we provide an overview of those findings from mice and men, and indicate several novel approaches that are now being exploited to further our knowledge of this fascinating enzyme family.
Hendriks
Wiljan J A J
WJ
Department of Cell Biology, Radboud University Nijmegen Medical Centre, The Netherlands. w.hendriks@ncmls.ru.nl
Elson
Ari
A
Harroch
Sheila
S
Stoker
Andrew W
AW
D000818:Animals; D004194:Disease / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000201:enzymology; D051379:Mice; D009857:Oncogenes; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000502:physiology*; D051381:Rats; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D025521:Tumor Suppressor Proteins; D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases