Aurora kinases as an anti-cancer target.
The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitosis and presents the rationale for these kinases as an anti-cancer target. I also review recently developed inhibitors of Aurora kinases.
Ikezoe
Takayuki
T
D064127:Aurora Kinases; D043171:Chromosomal Instability; D048749:Cytokinesis; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology
D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases