Progress in the studies on rutaecarpine.
Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. Recent progress in the studies on the isolation, synthesis, structure-activity relationship studies, biological activities and metabolism of rutaecarpine are reviewed.
Lee
Seung Ho
SH
College of Pharmacy, Yeungnam University, Gyeongsan 712-749 Korea.
Son
Jong-Keun
JK
Jeong
Byeong Seon
BS
Jeong
Tae-Cheon
TC
Chang
Hyeon Wook
HW
Lee
Eung-Seok
ES
Jahng
Yurngdong
Y
D000818:Animals; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D052999:Quinazolinones
D026121:Indole Alkaloids; D011799:Quinazolines; C028632:rutecarpine; D052999:Quinazolinones