Reagent-controlled domino synthesis of skeletally-diverse compound collections.
An efficient reagent-controlled methodology for generating highly substituted diverse scaffolds from a common substrate has been developed; thus, treatment of a common precursor with different desilylating reagents, such as ammonium fluoride, caesium fluoride and PPTS, triggers different domino reaction sequences, yielding highly substituted pyridines, phenols and benzopyrans, respectively; the substituent patterns of these scaffolds provide further opportunities for library development.
Waldmann
Herbert
H
Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. Herbert.Waldmann@mpi-dortmund.mpg.de
Kühn
Marc
M
Liu
Wei
W
Kumar
Kamal
K
D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure
D007202:Indicators and Reagents