title: Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease.
abstract: BACKGROUND
  Apolipoprotein E polymorphisms have important effects on plasma lipid levels and in the genetic susceptibility to development of cardiovascular diseases. Thus, the purpose of this study was to investigate the association of apolipoprotein E polymorphisms with coronary artery disease and with plasma lipid levels in a group of Mexican Mestizo patients.
  
  
  METHODS
  Apolipoprotein E polymorphisms were determined in 156 Mexican patients with coronary artery disease and 200 non-related healthy controls using the restriction fragment length polymorphism technique. The correlation of these polymorphisms with lipid profile (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides) in the patient group was determined.
  
  
  RESULTS
  A similar distribution of allele and genotype frequencies in coronary artery disease patients and healthy controls was found. Higher serum levels of high-density lipoprotein cholesterol and lower levels of low-density lipoprotein cholesterol, triglycerides and glucose were found in patients with the APOE*2/3 genotype when compared to patients with the APOE*3/4 and APOE*3/3 genotypes, although these differences were not significant.
  
  
  CONCLUSIONS
  Our data suggest that genetic variation at the APOE is not a genetic factor related to the genetic susceptibility to coronary artery disease in Mexican individuals, but the role of this polymorphism in determining the lipid profile cannot be excluded.
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gamboa
authors.forename: Claudia
authors.initials: C
authors.lastname: Huesca-Gómez
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
authors.forename: David
authors.initials: D
authors.lastname: Cruz-Robles
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.forename: Teresa
authors.initials: T
authors.lastname: Juarez-Cedillo
authors.forename: Maite
authors.initials: M
authors.lastname: Vallejo
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D001774:Blood Chemical Analysis / Q000379:methods; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL