title: 1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.
abstract: In our ongoing investigation of the bioactive constituents from plants, two new lignans, magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol were isolated from heartwood of Streblus asper, along with three known lignans, magnolignan A, magnolol, and magnaldehyde D. 1D and 2D NMR experiments, including COSY, HMQC, and HMBC, and other spectroscopic methods, including UV, IR, and MS were used for the determination of the structures and NMR assignments. Primary bioassays showed that magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, 46.4 microM and 10.1 microM, 21.7 microM, respectively.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Bai-Feng
authors.initials: BF
authors.lastname: Jin
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Su
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Tao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Yong-Cheng
authors.initials: YC
authors.lastname: Lin
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017705:Lignans / Q000008:administration & dosage* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D029586:Moraceae / Q000378:metabolism*; D011522:Protons; D014934:Wood / Q000737:chemistry*
chemical_list: D017705:Lignans; D011522:Protons