title: [Compared studies on the effect and toxicity of extractions of Fructus Meliae Toosendan in mice].
abstract: OBJECTIVE
  To evaluate the effect and acute toxicity of different extraction of Fructus Meliae Toosendan.
  
  
  METHODS
  Samples were extracted from Fructus Meliae Toosendan using petroleum ether (I), ethyl acetate (II), 80% alcohol (III) or water (IV). Miceś writhing response were induce by ip 0.9% acetic acid and foot ache were induced by sc formaldehyde. Mices feet or ears were smeated by sccarrageenin or dimethylbenzene. And the effects of these samples were evaluated on these models.
  
  
  RESULTS
  The sample II 40 g/kg significantly decreased the writhing response induced by acetic acid and relieved mice foot pain induced by formaldehyde, inhibited the swelling of mice ear induced by dimethylbenzene. It markedly decreased the body weight and increased the index of testes in mice. The sample III 20 g/kg inhibited foot swelling induced by carrageenin and ear swelling induced by dimethylbenzene in mice. The sample I significantly relieved the foot pain induced by formaldehyde, increased the indexes of testis and adrenal gland in mice. The sample IV had no action on pain or inflammatory in mice. The LD50 of the sample II was 82.85 g/kg. And ig the sample I 133.2 g/kg, sample III 122.0 g/kg or sample IV 52.0 g/kg could not induce mice to death.
  
  
  CONCLUSIONS
  The sample II has anti-inflammatory and antalgic action. But it also has serious acute toxicity. These results show that the efficacious component of Fructus Meilae Toosendan may exist in the ethyl acetate extraction, The toxicity and efficacious component may be the same material.
authors.affiliation: Sichuan Institute of Chinese Materia Medica, Sichuan Chengdu 610041, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
authors.forename: Yong
authors.initials: Y
authors.lastname: Lei
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Liang
authors.forename: Da-xuan
authors.initials: DX
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Zheng-huai
authors.initials: ZH
authors.lastname: Tan
mesh_terms: D000085:Acetates; D000700:Analgesics / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use* / Q000633:toxicity; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D000431:Ethanol; D005260:Female; D005638:Fruit / Q000737:chemistry; D008297:Male; D031585:Melia / Q000737:chemistry*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000188:drug therapy / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000085:Acetates; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D000431:Ethanol; C007650:ethyl acetate