title: Cerebral palsy after perinatal arterial ischemic stroke.
abstract: The frequency of cerebral palsy, degree of disability, and predictors of disability were assessed in children in a perinatal arterial stroke database. Risk factors were assessed at the univariate level using the Pearson chi(2) and Fisher exact test and at the multivariate level using logistic regression analysis. Seventy-six of 111 children with perinatal stroke (68%) had cerebral palsy, most commonly hemiplegic (66/76; 87%). Multivariate analysis of the entire cohort showed both delayed presentation (OR,9.96; 95% CI, 3.10-32.02) and male sex (OR, 2.55; 95% CI, 1.03-6.32) were associated with cerebral palsy. In subgroup multivariate analyses: in children with neonatal presentation, bilateral infarcts were associated with triplegia or quadriplegia (OR, 5.33; 95% CI, 1.28-22.27); in children with unilateral middle cerebral artery infarcts, delayed presentation (OR, 10.60; 95% CI, 2.28-72.92) and large-branch infarction (OR, 8.78; 95% CI, 2.18-43.67) were associated with cerebral palsy. These data will aid physicians in planning long-term rehabilitative care for children with perinatal stroke.
authors.affiliation: Division of Pediatric Neurology, Indiana University School of Medicine, 575 West Drive, Indianapolis, IN 46202, USA. mgolomb@iupui.edu
authors.forename: Meredith R
authors.initials: MR
authors.lastname: Golomb
authors.forename: Bhuwan P
authors.initials: BP
authors.lastname: Garg
authors.forename: Chandan
authors.initials: C
authors.lastname: Saha
authors.forename: Faouzi
authors.initials: F
authors.lastname: Azzouz
authors.forename: Linda S
authors.initials: LS
authors.lastname: Williams
mesh_terms: D002545:Brain Ischemia / Q000150:complications* / Q000453:epidemiology; D002536:Cerebral Arteries / Q000473:pathology; D002544:Cerebral Infarction / Q000150:complications* / Q000453:epidemiology; D002547:Cerebral Palsy / Q000453:epidemiology / Q000209:etiology*; D016009:Chi-Square Distribution; D002675:Child, Preschool; D015331:Cohort Studies; D004185:Disability Evaluation; D019988:Children with Disabilities; D005260:Female; D007839:Functional Laterality; D006429:Hemiplegia / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007196:Indiana / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications* / Q000453:epidemiology