title: Effect of acute lindane and alcohol intoxication on serum concentration of enzymes and fatty acids in rats.
abstract: This study examines possible synergistic effects of lindane and ethanol on inducing liver injury and serum fatty acid derangement in adult male Wistar rats. When administered together, ethanol and lindane-induced even more pronounced increase of alanine aminotransferase (165 +/- 10 U/L) and gamma-glutamyltranspeptidase activity (10.3 +/- 0.6 U/L) than after isolated administration of either substance. In addition, separate administration of lindane and ethanol was followed by a significant decrease of linoleic acid level in the serum (301 +/- 38 mg/L, 276 +/- 35 mg/L vs. 416 +/- 48 mg/L). However, when ethanol administration was followed by lindane injection, serum linoleic acid was at the similar level found in the control group (516 +/- 62 mg/L). Ethanol-treated rats that received lindane 30 min after ethanol administration have shown a marked increase of palmitic (421 +/- 27 mg/L) and linolic acid level (43 +/- 5 mg/L) in comparison with rats that have been treated only with ethanol (316+/-26 mg/L for palmitic and 32 +/- 2 mg/L for linolic acid) or lindane (295 +/- 26 mg/L for palmitic and 301 +/- 38 mg/L for linolic acid). Linolic acid level was significantly greater in comparison with control group (29 +/- 1 mg/L). In conclusion, this study found enough evidence to support the hypothesis that acute ethanol intoxication potentiates lindane-induced liver injury and enhances lipid derangement.
authors.affiliation: Department of Pathophysiology, School of Medicine, University of Belgrade, Belgrade, Serbia. tanjamm@med.bg.ac.yu
authors.forename: T
authors.initials: T
authors.lastname: Radosavljević
authors.forename: D
authors.initials: D
authors.lastname: Mladenović
authors.forename: D
authors.initials: D
authors.lastname: Vucević
authors.forename: J
authors.initials: J
authors.lastname: Petrović
authors.forename: D
authors.initials: D
authors.lastname: Hrncić
authors.forename: D
authors.initials: D
authors.lastname: Djuric
authors.forename: H
authors.initials: H
authors.lastname: Loncar-Stevanović
authors.forename: O
authors.initials: O
authors.lastname: Stanojlović
mesh_terms: D000435:Alcoholic Intoxication / Q000097:blood* / Q000201:enzymology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000097:blood; D000431:Ethanol / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002492:Central Nervous System Depressants; D005227:Fatty Acids; D007306:Insecticides; D000431:Ethanol; D001556:Hexachlorocyclohexane