title: Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae.
abstract: Pestalotheols A-D ( 1- 4 ), four new metabolites, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis theae. The structures of these compounds were determined by NMR spectroscopy, and 1 is further confirmed by X-ray crystallography. The absolute configurations of compounds 1 and 3 were assigned by application of the modified Mosher method. Pestalotheol C ( 3) displayed an inhibitory effect on HIV-1 LAI replication in C8166 cells with an EC 50 value of 16.1 microM.
authors.affiliation: Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China.
authors.forename: Erwei
authors.initials: E
authors.lastname: Li
authors.forename: Renrong
authors.initials: R
authors.lastname: Tian
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Xulin
authors.initials: X
authors.lastname: Chen
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D002681:China; D018360:Crystallography, X-Ray; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; C529353:pestalotheol C