Syntheses of manzacidins: a stage for the demonstration of synthetic methodologies.
Manzacidins, a family of bromopyrrole alkaloids, have attracted much attention from the synthetic community due to their intriguing structures, bearing chiral tertiary and secondary stereocentres in a 1,3-relationship, and biological activities. In this article, we summarise the approaches for the preparation of manzacidins using novel synthetic methodologies. Organocatalysis and Lewis acid catalysis, as well as transition-metal catalysis, offered efficient ways to access these molecules.
Hashimoto
Takuya
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Maruoka
Keiji
K
D003500:Cyclization; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D011743:Pyrimidines; D011758:Pyrroles; C470325:manzacidin A; C520151:manzacidin B; C470326:manzacidin C; C528770:manzacidin D