Sulfonic acid functionalized silica: an efficient heterogeneous catalyst for a three-component synthesis of 1,4-dihydropyridines under solvent-free conditions.
Sulfonic acid functionalized silica catalyzed the three-component reaction of aromatic amines, alpha,beta-unsaturated aldehydes and beta-keto esters forming the corresponding 1,4-dihydropyridines in short reaction times and in high yields.
Das
Biswanath
B
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India. biswanathdas@yahoo.com
Suneel
Kanaparthy
K
Venkateswarlu
Katta
K
Ravikanth
Bommena
B
D002384:Catalysis; D004095:Dihydropyridines / Q000138:chemical synthesis*; D004952:Esters / Q000737:chemistry; D007202:Indicators and Reagents; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013451:Sulfonic Acids / Q000737:chemistry*
D004095:Dihydropyridines; D004952:Esters; D007202:Indicators and Reagents; D012997:Solvents; D013451:Sulfonic Acids; D012822:Silicon Dioxide; C038806:1,4-dihydropyridine