Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity.
A novel 2,3-dioxygenated flavanone, erigeroflavanone ( 1), as well as eight known flavonoids and two known gamma-pyranone derivatives, were isolated from an ethyl acetate-soluble extract of the flowers of Erigeron annuus. The structure of compound 1 was elucidated by interpretation of spectroscopic data. All of the isolates were subjected to in vitro bioassays to evaluate their inhibitory activity against advanced glycation end products formation and rat lens aldose reductase.
Yoo
Nam Hee
NH
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
Jang
Dae Sik
DS
Yoo
Jeong Lim
JL
Lee
Yun Mi
YM
Kim
Young Sook
YS
Cho
Jung-Hee
JH
Kim
Jin Sook
JS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D049919:Erigeron / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D007723:Korea; D007908:Lens, Crystalline / Q000201:enzymology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D044950:Flavanones; D017127:Glycation End Products, Advanced; C529414:erigeroflavanone; D000449:Aldehyde Reductase