Kalman filter control of a model of spatiotemporal cortical dynamics.
Recent advances in Kalman filtering to estimate system state and parameters in nonlinear systems have offered the potential to apply such approaches to spatiotemporal nonlinear systems. We here adapt the nonlinear method of unscented Kalman filtering to observe the state and estimate parameters in a computational spatiotemporal excitable system that serves as a model for cerebral cortex. We demonstrate the ability to track spiral wave dynamics, and to use an observer system to calculate control signals delivered through applied electrical fields. We demonstrate how this strategy can control the frequency of such a system, or quench the wave patterns, while minimizing the energy required for such results. These findings are readily testable in experimental applications, and have the potential to be applied to the treatment of human disease.
Schiff
Steven J
SJ
Center for Neural Engineering, Departments of Neurosurgery, Engineering Sciences and Mechanics, and Physics, The Pennsylvania State University, University Park, PA 16802, USA.
Sauer
Tim
T
D000465:Algorithms; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D016014:Linear Models; D008959:Models, Neurological; D015233:Models, Statistical; D016571:Neural Networks, Computer; D017711:Nonlinear Dynamics