title: Application of turbo fluid-attenuated inversion-recovery MRI in evaluation of intraspinal tumors.
abstract: OBJECTIVE
  Although fluid-attenuated inversion-recovery (FLAIR) magnetic resonance imaging (MRI) is widely applied to diagnose central nervous system diseases, its role in diagnosis of intraspinal tumors is unclear. In this study, we evaluated the potential clinical application of a turbo FLAIR sequence for imaging of intraspinal tumors.
  
  
  METHODS
  Forty-eight consecutive patients with intraspinal tumors underwent MRI with turbo FLAIR and turbo spinal echo (TSE) sequences. Turbo FLAIR images were then qualitatively and quantitatively compared with T2-weighted TSE images.
  
  
  RESULTS
  Turbo FLAIR images were evaluated as superior to T2-weighted TSE images for image artifact, extradural tumor conspicuity, and intradural extramedullary tumor conspicuity and detection. Intramedullary tumor conspicuity with turbo FLAIR was less than T2-weighted TSE. Similar capabilities in detection of extradural and intramedullary tumors were found between turbo FLAIR and T2-weighted TSE. Turbo FLAIR and T2-weighted TSE displayed similar normal spinal cord signal-noise ratio (SNR) and tumor-to-cerebrospinal fluid (CSF) contrast-to-noise ratio (CNR). In addition, turbo FLAIR yielded significantly higher tumor-to-CSF contrast than T2-weighted TSE. However, tumor SNR, tumor-to-normal spinal cord contrast and CNR with turbo FLAIR images were lower than those with T2-weighted TSE images.
  
  
  CONCLUSIONS
  This study demonstrated (a) a superiority of turbo FLAIR to T2-weighted TSE in displaying and detecting intradural extramedullary tumors, (b) a superiority of turbo FLAIR to T2-weighted TSE in demonstrating extradural tumors, and (c) less usefulness in displaying intramedullary tumors with turbo FLAIR than with T2-weighted TSE.
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Province, Hangzhou City, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Sun
authors.forename: Shizheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Dingyao
authors.initials: D
authors.lastname: Jiang
authors.forename: Dejun
authors.initials: D
authors.lastname: Zhang
authors.forename: Xiufang
authors.initials: X
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis*