title: Synthetic GPI array to study antitoxic malaria response.
abstract: Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.
authors.affiliation: Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland.
authors.forename: Faustin
authors.initials: F
authors.lastname: Kamena
authors.forename: Marco
authors.initials: M
authors.lastname: Tamborrini
authors.forename: Xinyu
authors.initials: X
authors.lastname: Liu
authors.forename: Yong-Uk
authors.initials: YU
authors.lastname: Kwon
authors.forename: Fiona
authors.initials: F
authors.lastname: Thompson
authors.forename: Gerd
authors.initials: G
authors.lastname: Pluschke
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000737:chemistry*; D000937:Antigen-Antibody Reactions; D000953:Antigens, Protozoan / Q000737:chemistry* / Q000276:immunology; D002236:Carbohydrate Conformation; D017261:Glycosylphosphatidylinositols / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D008288:Malaria / Q000276:immunology; D017780:Malaria Vaccines / Q000138:chemical synthesis / Q000737:chemistry* / Q000276:immunology; D046228:Microarray Analysis / Q000379:methods*; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000276:immunology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D017261:Glycosylphosphatidylinositols; D017780:Malaria Vaccines; D011134:Polysaccharides