Modeling clonal expansion from M-FISH experiments.
A population genetic model is used to describe dynamical aspects of chromosomal abberations observed in M-FISH experiments. Linear differential equations model the evolution of relative frequencies of mutations. The unknown parameters involved are estimated by maximum likelihood methods. We propose a scoring system to select the most important mutations. In order to reduce the number of parameters and computation time, only the highest ranked mutations are considered. First applications to M-FISH data show rather promising results.
Stolte
Thomas
T
Centre for Mathematical Sciences, Technical University Munich, Garching/Munich, Germany.
Hösel
Volker
V
Müller
Johannes
J
Speicher
Michael
M
D002869:Chromosome Aberrations; D005828:Genetics, Population; D017404:In Situ Hybridization, Fluorescence; D016013:Likelihood Functions; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation