Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins.
We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.
Athanasiadou
Anastasia
A
Stamatopoulos
Kostas
K
Gaitatzi
Maria
M
Stavroyianni
Niki
N
Fassas
Athanasios
A
Anagnostopoulos
Achilles
A
D002869:Chromosome Aberrations; D022801:Complementarity Determining Regions / Q000235:genetics*; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics*; D007134:Immunoglobulin Switch Region; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics*; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*
D022801:Complementarity Determining Regions; D007074:Immunoglobulin G; D009363:Neoplasm Proteins; D011947:Receptors, Antigen, B-Cell