title: A comparison of circulating TNF-alpha in obese and lean women with and without preeclampsia.
abstract: OBJECTIVE
  We hypothesized that TNF-alpha would be higher in obese versus lean women with preeclampsia.
  
  
  METHODS
  Total plasma TNF-alpha was measured in a nested case-control study of 123 nulliparous lean and obese control women and women with preeclampsia.
  
  
  RESULTS
  Adjusted mean TNF-alpha concentrations were 0.97 +/- 0.11 (pg/mL +/- SEM) in lean controls, 1.01 +/- 0.10 in obese controls, 1.43 +/- 0.11 in lean women with preeclampsia and 1.16 +/- 0.11 in obese women with preeclampsia. Pregnancy outcome was the single predictor of TNF-alpha concentration in the general linear regression model (p = 0.04).
  
  
  CONCLUSIONS
  TNF-alpha concentration was higher in preeclampsia compared with control subjects. Obesity was not associated with higher TNF-alpha concentrations in either preeclampsia or control subjects.
authors.affiliation: University of Pittsburgh School of Nursing, Pittsburgh, PA 15261, USA. safounds@comcast.net
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Founds
authors.forename: Robert W
authors.initials: RW
authors.lastname: Powers
authors.forename: Thelma E
authors.initials: TE
authors.lastname: Patrick
authors.forename: Dianxu
authors.initials: D
authors.lastname: Ren
authors.forename: Gail F
authors.initials: GF
authors.lastname: Harger
authors.forename: Nina
authors.initials: N
authors.lastname: Markovic
authors.forename: James M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013851:Thinness / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D014409:Tumor Necrosis Factor-alpha