title: Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding.
abstract: Obsessive-compulsive disorder (OCD) is likely a disorder involving complex genetic transmission. This suggests that multiple genetic and environmental factors are involved in its etiology. This is complicated further by the probability of genetic heterogeneity for this phenotype. In this report, we describe a preliminary approach to deal with both complexities. SLC1A1, a glutamate transporter gene on chromosome 9p, was originally proposed to be related to OCD based on two linkage studies, and subsequently association of OCD to the gene has been replicated. Additionally, genetic linkage to a subtype of OCD, compulsive hoarding, has been reported on chromosome 14q. We hypothesized that both genomic regions contribute to OCD in some instances. Using the analytic program GENEFINDER we found that conditioning linkage on chromosome 14q to a marker adjacent to SLC1A1, reduced the size of the linkage region on chromosome 14q and provided evidence for interaction between the regions on chromosomes 9p and 14q.
authors.affiliation: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
authors.forename: Kung-Yee
authors.initials: KY
authors.lastname: Liang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yin Yao
authors.initials: YY
authors.lastname: Shugart
authors.forename: Marco
authors.initials: M
authors.lastname: Grados
authors.forename: Abby J
authors.initials: AJ
authors.lastname: Fyer
authors.forename: Scott
authors.initials: S
authors.lastname: Rauch
authors.forename: Dennis
authors.initials: D
authors.lastname: Murphy
authors.forename: James
authors.initials: J
authors.lastname: McCracken
authors.forename: Steven
authors.initials: S
authors.lastname: Rasmussen
authors.forename: Bernadette
authors.initials: B
authors.lastname: Cullen
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hoehn-Saric
authors.forename: Benjamin
authors.initials: B
authors.lastname: Greenberg
authors.forename: Anthony
authors.initials: A
authors.lastname: Pinto
authors.forename: James
authors.initials: J
authors.lastname: Knowles
authors.forename: John
authors.initials: J
authors.lastname: Piacentini
authors.forename: David
authors.initials: D
authors.lastname: Pauls
authors.forename: O
authors.initials: O
authors.lastname: Bienvenu
authors.forename: Mark
authors.initials: M
authors.lastname: Riddle
authors.forename: Jack
authors.initials: J
authors.lastname: Samuels
authors.forename: Gerald
authors.initials: G
authors.lastname: Nestadt
mesh_terms: D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002899:Chromosomes, Human, Pair 9; D003192:Compulsive Behavior / Q000235:genetics*; D030541:Databases, Genetic; D004843:Epistasis, Genetic; D050580:Excitatory Amino Acid Transporter 3 / Q000235:genetics*; D005190:Family; D008040:Genetic Linkage; D006801:Humans; D018895:Microsatellite Repeats; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000503:physiopathology; D012984:Software
chemical_list: D050580:Excitatory Amino Acid Transporter 3; C493400:SLC1A1 protein, human