title: The impact of macular laser photocoagulation on contrast sensitivity function in patients with clinically significant macular edema.
abstract: BACKGROUND
  Contrast sensitivity is an important aspect of visual function and is even more important for ordinary daily tasks than visual acuity. Contrast sensitivity function may be deteriorated to a significant level in diabetic retinopathy, especially in diabetic macular edema. The objective of this study was to determine the impact of macular laser photocoagulation-as the standard treatment of clinically significant macular edema-on contrast sensitivity function.
  
  
  METHODS
  In a prospective noncomparative interventional case series, 17 patients with clinically significant bilateral macular edema and no history of prior macular laser photocoagulation were enrolled. Baseline visual acuity, contrast sensitivity function, and fluorescein angiography were obtained and reassessed three months after macular laser photocoagulation.
  
  
  RESULTS
  Clinically significant macular edema resolved in 22 (65%) of 34 eyes, three months after their first session of macular laser photocoagulation. The mean pretreatment visual acuity was 24.5/40 (0.21 logMAR) +/-10.3/40. Three months after macular photocoagulation, visual acuity remained stable in 19 eyes, decreased in 12 eyes, and increased in three eyes. The mean post-treatment visual acuity was 24/40 (0.24 logMAR) +/-10.8/40. There was a statistically significant (P = 0.02) decrease in visual acuity following laser therapy. In subgroup analysis, this decrease in visual acuity was only observed in those with unresolved clinically significant macular edema. The mean contrast sensitivity threshold increased in all spatial frequencies by three months after macular photocoagulation. The maximum rise was observed in the frequency of 6.4 cycles per degree in the mid range of frequencies, with a pretreatment mean of 9.41 dB and a post-treatment mean of 11.50 dB (P<0.05).
  
  
  CONCLUSIONS
  Contrast sensitivity function improved after macular laser photocoagulation in clinically significant macular edema patients.
authors.affiliation: Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran. Farahva@yahoo.com
authors.forename: Mohammad-Sadegh
authors.initials: MS
authors.lastname: Farahvash
authors.forename: Amir-Hossein
authors.initials: AH
authors.lastname: Mahmoudi
authors.forename: Mohammad-Mehdi
authors.initials: MM
authors.lastname: Farahvash
authors.forename: Ali
authors.initials: A
authors.lastname: Tabatabaee
authors.forename: Mohammad
authors.initials: M
authors.lastname: Riazi
authors.forename: Shiva
authors.initials: S
authors.lastname: Mohammadzadeh
authors.forename: Houshang
authors.initials: H
authors.lastname: Faghihi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nilli-Ahmadabadi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mirshahi
authors.forename: Reza
authors.initials: R
authors.lastname: Karkhaneh
authors.forename: Zahra
authors.initials: Z
authors.lastname: Aalami-Harandi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Javadian
authors.forename: Ali
authors.initials: A
authors.lastname: Abdolahi
authors.forename: Alireza
authors.initials: A
authors.lastname: Lashey
mesh_terms: D015350:Contrast Sensitivity / Q000502:physiology*; D003930:Diabetic Retinopathy / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D015203:Reproducibility of Results; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology