[Cellular parameters quantification, prognostic assessment of cervical squamous cell carcinoma].
Invasive squamous cell carcinoma develops from squamous intraepithelial lesions (SIL), that is why women with this tumour have the same epidemiologic characteristics to those with preinvasive precursor lesions.


METHODS
We have investigated 34 cases of intraepithelial squamous lesions, cytological and histopathological diagnosis.


RESULTS
For the biphasic quantification, there were taken in consideration all the established parameters (area, perimeter, diameter, long axis, short axis, roundness, eccentricity) and the results are presented for nucleus and nucleolus. For proliferative activity, there were quantified the mitotic activity index and mitotic density, the results being presented for high grade cervical intraepithelial neoplasia (CIN 3).


CONCLUSIONS
Biphasic measurement could be useful in diagnostic and prognostic of different grades of squamous carcinomas, adenocarcinomas or undifferentiated carcinomas, but not in assessment of malignancy risk of some dysplasias.
Pandeli
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Universitatea de Medicină Si Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină, Clinica a II-a Obstetrică Ginecologie.
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D003196:Computer Graphics; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*