Antifouling metabolites from the mangrove plant Ceriops tagal.
The new diterpene methoxy-ent-8(14)-pimarenely-15-one (1) and three known metabolites: ent-8(14)-pimarene-15R,16-diol (2), stigmasterol (3) and beta-sitosterol (4), were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means of extensive NMR, IR and MS analysis. Compounds 1, 2, 3 and 4 exhibited significant antifouling activities against cyprid larvae of the barnacle Balanus albicostatus Pilsbry, with EC(50) values of 0.32 +/- 0.01, 0.04 +/- 0.00,4.05 +/- 0.15 and 18.47 +/- 0.40 microg/cm(2), respectively, whereas their toxicities towards cyprids were very low, with LC(50 )values all above 10 microg/cm(2).
Chen
Jun De
JD
Department of Biology, School of Life Sciences, Xiamen University, Xiamen 361005, PR China.
Feng
Dan Qin
DQ
Yang
Zhi Wei
ZW
Wang
Zhan Chang
ZC
Qiu
Yan
Y
Lin
Yi Ming
YM
D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018517:Plant Roots / Q000737:chemistry; D011522:Protons; D043982:Rhizophoraceae / Q000737:chemistry*; D016019:Survival Analysis; D001468:Thoracica / Q000187:drug effects
D004224:Diterpenes; D011522:Protons