title: Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report.
abstract: BACKGROUND
  Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis.
  
  
  METHODS
  We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor.
  
  
  CONCLUSIONS
  We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence.
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. syamama1945@yahoo.co.jp
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Terasaka
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ando
authors.forename: Toshiya
authors.initials: T
authors.lastname: Shinohara
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D020360:Neoadjuvant Therapy; D019635:Neurosurgical Procedures; D010954:Plasmacytoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016879:Salvage Therapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin