Biology of somatostatin in breast cancer.
The biological effects of the neuropeptide somatostatin (SST) are mediated via a family of five somatostatin receptors (SSTRs) belonging to a family of G-protein-coupled receptors (GPCRs). SSTR regulate the secretion of hormones, growth factors, neurotransmission and cell growth in receptor-specific manner. In addition, SST plays an inhibitory role in several mammary cancer models. These effects are mediated both indirectly through inhibition of hormones and growth factors which promote tumor growth as well as directly via SSTRs present on tumor cells to inhibit mitogenic signaling of growth factor receptor kinases leading to growth arrest and induction of apoptosis. Here, we present an overview on the role of SST and its analogs in breast cancer.
Watt
Heather L
HL
Department of Medicine, Royal Victoria Hospital, McGill University, Canada.
Kharmate
G
G
Kumar
Ujendra
U
D000595:Amino Acid Sequence; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D017481:Receptors, Somatostatin / Q000819:agonists / Q000502:physiology*; D015398:Signal Transduction; D013004:Somatostatin / Q000031:analogs & derivatives / Q000502:physiology* / Q000627:therapeutic use
D018931:Antineoplastic Agents, Hormonal; D017481:Receptors, Somatostatin; D013004:Somatostatin