Inflammatory marker but not adipokine predicts mortality among long-term hemodialysis patients.
OBJECTIVE
chronic inflammation contributes significantly to the morbidity and mortality of chronic hemodialysis patients. A recent research has shown that adipokines were associated with inflammation in these patients. We aim to investigate whether biomarkers of inflammation, adipokines, and clinical features can predict the outcome of hemodialysis patients.


METHODS
we enrolled 181 hemodialysis patients (men: 97, mean age: 56.3+/-13.6) and analyzed predictors of long-term outcomes.


RESULTS
during the 3-year followup period, 41 patients died; the main causes of death were infection and cardiovascular disease. Elevated serum levels of hsCRP and albumin and advanced age were highly associated with death (all P<.001). Leptin and adiponectin levels were not significantly different between deceased patients and survivors. Cox-regression analysis indicated that age, diabetes, albumin level, and hsCRP were independent factors predicting mortality.


CONCLUSIONS
the presence of underlying disease, advanced age, and markers of chronic inflammation is strongly related to survival rate in long-term hemodialysis patients.
Tsai
Yu-Che
YC
Division of Nephrology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung Hsien 833, Taiwan.
Lee
Chien-Te
CT
Huang
Tiao-Lai
TL
Cheng
Ben-Chung
BC
Kuo
Chien-Chun
CC
Su
Yih
Y
Ng
Hwee-Yeong
HY
Yang
Chih-Chau
CC
Chuang
Fong-Rong
FR
Liao
Shang-Chih
SC
D054392:Adipokines / Q000378:metabolism*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
D054392:Adipokines; D015415:Biomarkers