title: [Analysis of the risk factors causing tracheal stenosis after tracheotomy for mechanical ventilation in 560 patients].
abstract: OBJECTIVE
  To investigate the risk factors causing tracheal stenosis after tracheotomy for mechanical ventilation.
  
  
  METHODS
  A retrospective study was carried out to review the clinical data of 560 patients who had been tracheotomy for mechanical ventilation in the First Affiliated Hospital of Sun Yat-sen University from 1990 to 2006. The clinical relevant factors causing tracheal stenosis included age, sex, preoperative intubation, preoperative intubation time, postoperative mechanical ventilation duration, airway infection, multiple changes of intubation tube, cricothyroidotomy, previous tracheotomy, gastroesophageal reflux, diabetes, etc. Multivariate stepwise logistic regression model was used for the analysis.
  
  
  RESULTS
  Fifty-four cases (9.6%) presented tracheal stenosis in 560 patients after tracheotomy. With multivariate analysis, it was confirmed that the following variable correlated to tracheal stenosis. i.e, preoperative intubation time (chi2 = 4.323, P = 0.038), postoperative mechanical ventilation duration (chi2 = 14.062, P = 0.000), airway infection (chi2 = 8.604, P = 0.004), diabetes (chi2 = 5.237, P = 0.014). The effect degree of these risk factors was as below, postoperative mechanical ventilation duration (OR = 10.818), airway infection (OR = 6.349), diabetes (OR = 3.019), intubation time preoperative (OR = 2.156).
  
  
  CONCLUSIONS
  Among patients who received tracheotomy for mechanical ventilation, the clinical relevant factors causing tracheal stenosis were various. Statistical analysis showed that preoperative intubation time, postoperative mechanical ventilation duration, diabetes, airway infection were main risky factors which may cause tracheal stenosis.
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital of SUN Yat-sen University, Guangzhou 510080, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wu
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Su
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Hu
authors.forename: Ai-Yun
authors.initials: AY
authors.lastname: Jiang
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Wen
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Lei
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012121:Respiration, Artificial / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D014135:Tracheal Stenosis / Q000209:etiology*; D014140:Tracheotomy / Q000009:adverse effects*; D055815:Young Adult