Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique.
Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs.51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.
Tovar
Marco
M
Departamento de Microbiologia, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
Siedner
Mark J
MJ
Gilman
Robert H
RH
Santillan
Carlos
C
Caviedes
Luz
L
Valencia
Teresa
T
Jave
Oswaldo
O
Escombe
A Rod
AR
Moore
David A J
DA
Evans
Carlton A
CA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology; D003470:Culture Media; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D012680:Sensitivity and Specificity; D013997:Time Factors; D014396:Tuberculosis, Pleural / Q000175:diagnosis* / Q000382:microbiology
D000995:Antitubercular Agents; D003470:Culture Media