title: Alpha-fetoprotein (AFP)-producing adrenocortical carcinoma--long survival with various therapeutic strategies including a lung resection: report of a case.
abstract: We experienced a very rare case of late pulmonary metastasis from ACC. The patient was a 40-year-old woman who had undergone a left adrenectomy 12 years earlier. Instead of a large metastatic lung tumor with hemothorax and the existence of metastases in other organs, combined therapy of repeated resections for metastases and adjuvant therapy allowed for almost a 36-month survival following the first recurrence and a good quality of life. In addition, a blood and pathological study revealed that the tumor in this case was an alpha-fetoprotein-producing ACC, which is, as far as we could ascertain, the first case of its kind.
authors.affiliation: Department of Thoracic Surgery, Imakiire General Hospital, 4-16 Shimotatsuo-cho, Kagoshima 892-0852, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Hamanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoneda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shirakusa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shirahama
authors.forename: Yukie
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Tsuru
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D011013:Pneumonectomy; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins