Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus.
Premature newborn baboons [125 d (67%) gestation], exposed to a moderate-size patent ductus arteriosus (PDA) [pulmonary-to-systemic blood-flow-ratio (Qp/Qs) = 1.8] for 14 d, have impaired pulmonary function and arrested alveolar development and surface area when compared with age matched fetuses (140 d gestation). Pharmacologic closure of the PDA reduces the detrimental effects of preterm delivery on pulmonary function and surface area. We used preterm baboons (delivered at 125 d gestation and ventilated for 14 d) to study the effects of surgical PDA ligation on pulmonary function and alveolar surface area. After ligation (on day of life 6), ligated animals had lower Qp/Qs ratios [Qp/Qs (ligated, n = 10) = 1.00 +/- 0.04; (nonligated, n = 12) = 2.05 +/- 0.17; mean +/- SD] and higher systemic blood pressures than nonligated control animals. Ventilation and oxygenation indices did not differ between the groups, during either the pre- or postoperative periods. Alveolar surface area measurements were made by digital image analysis and compared with measurements made from fetal lungs at 125 d (n = 6) and 140 d (n = 7) gestation. PDA ligation failed to improve the postnatal arrest in alveolar surface area. In contrast with pharmacologic closure of the PDA, surgical closure failed to improve either pulmonary function or alveolar surface area in baboons with a moderate PDA shunt.
Chang
Ling Yi
LY
Department of Medicine, University of Colorado, Denver, Colorado 80204, USA.
McCurnin
Donald
D
Yoder
Bradley
B
Shaul
Phillip W
PW
Clyman
Ronald I
RI
D000818:Animals; D001794:Blood Pressure; D006348:Cardiac Surgical Procedures; D004195:Disease Models, Animal; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005865:Gestational Age; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use; D008026:Ligation; D008170:Lung Compliance; D008297:Male; D048531:Papio papio; D047928:Premature Birth; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000196:embryology / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology; D011652:Pulmonary Circulation; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D007052:Ibuprofen