title: Timing and correlates of very early major adverse clinical events following percutaneous coronary intervention.
abstract: We attempted to determine the incidence, timing and correlates of very early (< 24 hours) major adverse clinical events in patients undergoing contemporary percutaneous coronary intervention (PCI). Early discharge following PCI may offer significant advantages to patient and practitioner, but the timing of, and risk factors for, very early (< 24 hours) major adverse clinical events following PCI are not well characterized. A retrospective analysis of the CREDO trial was performed. A total of 1,815 patients underwent a PCI procedure and 139 patients (7.7%) experienced a major adverse clinical event (death, myocardial infarction or urgent target vessel revascularization) within the first 28 days. The majority of these events (111 patients) occurred within the first 24 hours, with the greatest risk of an event within the first 6 hours. Multivariable predictors of very early events were age, AHA lesion grade, history of peripheral vascular disease, preprocedural TIMI flow grade and no. of vessels with stenosis > 50%. These data show a very low and constant risk of adverse events 6 hours following PCI.
authors.affiliation: University of Kentucky, Gill Heart Institute, 900 South Limestone Avenue, 326 Charles T. Wethington Bldg., Lexington, KY, 40536-0200, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Jozic
authors.forename: James
authors.initials: J
authors.lastname: Orford
authors.forename: Steven
authors.initials: S
authors.lastname: Steinhubl
authors.forename: Peter
authors.initials: P
authors.lastname: Berger
authors.forename: Amy
authors.initials: A
authors.lastname: Hsu
authors.forename: Eric
authors.initials: E
authors.lastname: Topol
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D003327:Coronary Disease / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology*; D017063:Outcome Assessment, Health Care; D010351:Patient Discharge; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors