A defective angiogenesis in chronic kidney disease.
BACKGROUND
A progressive reduction in peritubular capillary flow is observed in chronic kidney disease (CKD) patients as the disease severity progresses. This suggests an altered vascular homeostasis in CKD patients, but such a defective mechanism needs to be verified.


METHODS
To study the vascular injury as reflected by circulating endothelial cell (CEC), the balance between angiogenic factor, vascular endothelial growth factor (VEGF), and antiangiogenic factor, endostatin.


RESULTS
A deficient VEGF was observed, whereas the value of endostatin and CEC were abnormally elevated in CKD patients.


CONCLUSIONS
Enhanced CEC reflects an increased activity of vascular injury. A deficient VEGF in the presence of enhanced antiangiogenesis (endostatin) implies a defective angiogenesis. This may explain the progressive nature of renal microvascular disease observed in late stage of CKD patients.
Futrakul
Narisa
N
King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Butthep
Punnee
P
Laohareungpanya
Narumon
N
Chaisuriya
Papada
P
Ratanabanangkoon
Kavi
K
D016022:Case-Control Studies; D018450:Disease Progression; D043169:Endostatins / Q000032:analysis; D042783:Endothelial Cells / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology* / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D043169:Endostatins; D042461:Vascular Endothelial Growth Factor A