Diagnosis and management of pleomorphic sarcomas (so-called "MFH") in adults.
The existence of "malignant fibrous histiocytoma" ("MFH") as a distinct entity is controversial. Previously accepted as the most common sarcoma affecting adults, it is now known to comprise a heterogeneous group of tumors without a specific known line of differentiation. Reclassification of many tumors in this group afforded better prognostication, but traditional treatments still apply. Pleomorphic soft tissue tumors for which a line of differentiation is debatable are presently categorized as undifferentiated pleomorphic sarcoma.
Nascimento
Alessandra F
AF
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. anascimento@partners.org
Raut
Chandrajit P
CP
D000328:Adult; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D051677:Histiocytoma, Malignant Fibrous / Q000145:classification / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000628:therapy; D008080:Liposarcoma / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012509:Sarcoma / Q000145:classification / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*