title: Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury.
abstract: Matrix metalloproteineases are associated with extracellular remodeling that occurs in injury and repair processes in the central nervous system (CNS). We examined the role of MMP-2 in a model of olfactory nerve injury and found that MMP-2 levels increased several hours following injury, peaked at day 7 and then decreased rapidly. We previously reported a rapid increase in MMP-9, within 5 h after nerve injury, corresponding to neuronal degeneration and increased glial activity. In this study, we show that MMP-2 peaks later than MMP-9, at the onset of neuronal regeneration and repair. Using MMP-9 knockout mice, we determined that the MMP-2 increase is independent of MMP-9. Our data suggest that MMP-2 and MMP-9 may play different roles in the injury and repair processes.
authors.affiliation: Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA. rconstanz@vcu.edu
authors.forename: Richard M
authors.initials: RM
authors.lastname: Costanzo
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Perrino
mesh_terms: D000818:Animals; D015153:Blotting, Western; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009416:Nerve Regeneration / Q000502:physiology; D009830:Olfactory Bulb / Q000201:enzymology; D061219:Olfactory Nerve Injuries
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9