Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading.
The cytological Ki-67 expression measured on cytological samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETs) management. The aim of our study was to assess reliability of Ki-67 expression measured on cytological samples obtained by EUS-FNAC in patients with PETs. Eighteen patients with PETs underwent EUS-FNAC before surgery. Ki-67 expression was measured on FNACs and on histological sections. Using a cut-off of 2%, percent agreement of Ki-67 expression on cytological and histological samples was 89% (k-statistic: 0.78, 95% confidence intervals (95% CI): 0.5, 1.0). Using cut-off values of 2 and 10%, percent agreement was 78% (k-statistic: 0.65, 95% CI: 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples.
Piani
Cecilia
C
General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Via Olgettina 60, Milano, Italy.
Franchi
Giulia M
GM
Cappelletti
Chiara
C
Scavini
Marina
M
Albarello
Luca
L
Zerbi
Alessandro
A
Giorgio Arcidiacono
Paolo
P
Bosi
Emanuele
E
Manzoni
Marco F
MF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002454:Cell Differentiation; D019160:Endosonography; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007340:Insulinoma / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D011300:Preoperative Care; D011379:Prognosis
D019394:Ki-67 Antigen