Purine alkaloids from the South China Sea gorgonian Subergorgia suberosa.
Four new purine alkaloids, namely, 6-(1'-purine-6',8'-dionyl)suberosanone ( 1), 3,9-(2-imino-1-methyl-4-imidazolidinone-5-yl)isopropenylpurine-6,8-dione ( 2), 1-(3'-carbonylbutyl)purine-6,8-dione ( 3), and 9-(3'-carbonylbutyl)purine-6,8-dione ( 4), together with three known compounds, guanosine ( 5), thymidine ( 6), and adenosine ( 7), were isolated from the EtOH/CH 2Cl 2 extracts of the South China Sea gorgonian Subergorgia suberosa. The structures of 1- 4 were determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1- 4 all showed weak cytotoxicity toward human cancer cell lines MDA-MB-231 and A435.
Qi
Shu-Hua
SH
Key Laboratory of Marine Bio-resourses Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, Guangdong, People's Republic of China. shuhuaqi2001@yahoo.com
Zhang
Si
S
Huang
Hui
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011687:Purines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D000970:Antineoplastic Agents; D011687:Purines