title: Trace element profiles in single strands of human hair determined by HR-ICP-MS.
abstract: Trace element analysis of human hair has the potential to reveal retrospective information about an individual's nutritional status and exposure. As trace elements are incorporated into the hair during the growth process, longitudinal segments of the hair may reflect the body burden during the growth period. We have evaluated the potential of human hair to indicate exposure or nutritional status over time by analysing trace element profiles in single strands of human hair. The hair strands from five healthy and occupationally unexposed subjects were cut into 1-cm long segments starting from the scalp. By using high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), we achieved profiles of 12 elements in single strands of human hair, namely, Ag, As, Au, Cd, Cu, Hg, Fe, Pb, Se, Sr, U and Zn. We have shown that trace element analysis along single strands of human hair can yield information about essential and toxic elements, and for some elements, can be correlated with seasonal changes in diet and exposure. The information obtained from the trace element profiles of human hair in this study substantiates the potential of hair as a biomarker.
authors.affiliation: Department of Chemistry, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway. kristin.gellein@chem.ntnu.no
authors.forename: Kristin
authors.initials: K
authors.lastname: Gellein
authors.forename: Syverin
authors.initials: S
authors.lastname: Lierhagen
authors.forename: Per Steinar
authors.initials: PS
authors.lastname: Brevik
authors.forename: Marte
authors.initials: M
authors.lastname: Teigen
authors.forename: Parvinder
authors.initials: P
authors.lastname: Kaur
authors.forename: Tajeshwar
authors.initials: T
authors.lastname: Singh
authors.forename: Trond Peder
authors.initials: TP
authors.lastname: Flaten
authors.forename: Tore
authors.initials: T
authors.lastname: Syversen
mesh_terms: D006197:Hair / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D014131:Trace Elements / Q000032:analysis*
chemical_list: D014131:Trace Elements