title: A novel one-step method for the synthesis of C-5-substituted Omicron6,5'-cyclopyrimidine nucleoside analogues in ammonia water.
abstract: A novel one-step method for preparing C-5-substituted Omicron(6),5'-cyclopyrimidine nucleoside analogues is reported. This method employs molecular iodine to mediate the cyclization from the 5'-Omicron-hydroxyl group of the sugar ring and C-6 at the position of the nitrogen base in ammonia water under mild conditions without any other aprotic organic solvent.
authors.affiliation: College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, Henan, P R China.
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
authors.forename: Bo
authors.initials: B
authors.lastname: Ren
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Mao
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
mesh_terms: D000641:Ammonia / Q000737:chemistry*; D003500:Cyclization; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: D011741:Pyrimidine Nucleosides; D012996:Solutions; D014867:Water; D000641:Ammonia