title: Using heparin therapy to reverse protein-losing enteropathy in a patient with CDG-Ib.
abstract: BACKGROUND
  A 22-year-old female presented with edema, diarrhea, hypoalbuminemia and pancytopenia. She had previously been diagnosed with congenital disorder of glycosylation type Ib, and had a history of congenital hepatic fibrosis, portal hypertension and esophageal varices. In the past she had refused mannose therapy because of associated diarrhea and abdominal pain.
  
  
  METHODS
  Laboratory examinations, abdominal ultrasonography, bacterial and viral cultures of blood, urine and stools, double-balloon enteroscopy and fecal excretion test using 51Cr-labeled albumin.
  
  
  METHODS
  Protein-losing enteropathy.
  
  
  RESULTS
  Infusion of albumin followed by intravenous and subcutaneous therapy with unfractionated heparin.
authors.affiliation: Department of Internal Medicine, Erasmus University Medical Center, Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors.forename: Ylian S
authors.initials: YS
authors.lastname: Liem
authors.forename: Lars
authors.initials: L
authors.lastname: Bode
authors.forename: Hudson H
authors.initials: HH
authors.lastname: Freeze
authors.forename: Frank Wg
authors.initials: FW
authors.lastname: Leebeek
authors.forename: Adrienne Am
authors.initials: AA
authors.lastname: Zandbergen
authors.forename: Jh
authors.initials: J
authors.lastname: Paul Wilson
mesh_terms: D000328:Adult; D000418:Albumins / Q000008:administration & dosage*; D018981:Congenital Disorders of Glycosylation / Q000145:classification / Q000150:complications; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000418:Albumins; D006493:Heparin