title: Synthesis of novel C6-phosphonated purine nucleosides under microwave irradiation by SNAr-Arbuzov reaction.
abstract: Novel C6-phosphonated purine nucleosides were obtained in good to excellent isolated yields by the simple and catalyst-free SNAr-Arbuzov reaction of trialkyl phosphite with 6-choloropurine nucleosides, including a series of nonsugar carbon nucleosides. Shorter reaction times were needed, and substantially higher yields were obtained under microwave irradiation conditions compared with conventional heating conditions.
authors.affiliation: College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, Henan, P R China. ghm@henannu.edu.cn
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
authors.forename: Ran
authors.initials: R
authors.lastname: Xia
authors.forename: Xi-Ning
authors.initials: XN
authors.lastname: Yang
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Li
authors.forename: Dong-Chao
authors.initials: DC
authors.lastname: Wang
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
mesh_terms: D013058:Mass Spectrometry; D008872:Microwaves; D063065:Organophosphonates / Q000138:chemical synthesis*; D011684:Purine Nucleosides / Q000138:chemical synthesis*
chemical_list: D063065:Organophosphonates; D011684:Purine Nucleosides