Pathologic aspects of inflammatory breast cancer: part 2. Biologic insights into its aggressive phenotype.
Inflammatory breast cancer (IBC) is the most aggressive and distinct form of primary breast cancer with a peculiar clinical presentation and dismal clinical outcome. This review addresses the pathologic aspects of this entity and discusses the molecular alterations involved in the highly malignant phenotype of IBC.
Gong
Yun
Y
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. yungong@mdanderson.org
D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D002277:Carcinoma / Q000150:complications / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology*; D042583:Lymphangiogenesis / Q000502:physiology; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000473:pathology
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules