Pinning down signaling in the immune system: the role of the peptidyl-prolyl isomerase Pin1 in immune cell function.
The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.
Esnault
Stephane
S
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine and UW-Madison School of Medicine and Public Health, Madison, WI 53705, USA.
Shen
Zong-Jian
ZJ
Malter
James S
JS
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D007107:Immune System; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D022021:Tacrolimus Binding Proteins / Q000378:metabolism*
D016207:Cytokines; D022021:Tacrolimus Binding Proteins; D019696:Peptidylprolyl Isomerase