title: Protein tyrosine phosphatases: regulatory mechanisms.
abstract: Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
authors.affiliation: Hubrecht Institute, Utrecht, the Netherlands. j.denhertog@niob.knaw.nl
authors.forename: Jeroen
authors.initials: J
authors.lastname: den Hertog
authors.forename: Arne
authors.initials: A
authors.lastname: Ostman
authors.forename: Frank-D
authors.initials: FD
authors.lastname: Böhmer
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D019281:Dimerization; D006801:Humans; D008024:Ligands; D010084:Oxidation-Reduction; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017027:Protein Tyrosine Phosphatases / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*
chemical_list: D008024:Ligands; D017027:Protein Tyrosine Phosphatases