Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia.
The study was undertaken with the aim to outline deletion patterns involving the long arm of chromosome 6, a common abnormality in lymphoproliferative disorders. Using a chromosome 6 specific tile path array, 60 samples from in total 49 cases with mantle cell lymphoma (MCL), de novo diffuse large B-cell lymphoma (DLBCL), transformed DLBCL as well as preceding follicular lymphoma (FL), and childhood acute lymphoblastic leukemia (ALL), were characterized. Twenty-six of the studied cases, representing all diagnoses, showed a 6q deletion among which 85% involved a 3 Mb region in 6q21. The minimal deleted interval in 6q21 encompasses the FOXO3A, PRDM1 and HACE1 candidate genes. The PRDM1 gene was found homozygously deleted in a case of DLBCL. Moreover, in two DLBCL cases, an overlapping homozygous deletion was identified in 6q23.3 - 24.1, encompassing the TNFAIP3 gene among others. Taken together, we refined the deletion pattern within the long arm of chromosome 6 in four different types of hematological malignances, suggesting the location of tumor suppressor genes involved in the tumor progression.
Thelander
Emma Flordal
EF
Medical Genetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Ichimura
Koichi
K
Corcoran
Martin
M
Barbany
Gisela
G
Nordgren
Ann
A
Heyman
Mats
M
Berglund
Mattias
M
Mungall
Andy
A
Rosenquist
Richard
R
Collins
V Peter
VP
Grandér
Dan
D
Larsson
Catharina
C
Lagercrantz
Svetlana
S
D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000235:genetics*; D008224:Lymphoma, Follicular; D016403:Lymphoma, Large B-Cell, Diffuse; D020522:Lymphoma, Mantle-Cell; D000074462:Positive Regulatory Domain I-Binding Factor 1; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1; C497506:HACE1 protein, human; D044767:Ubiquitin-Protein Ligases