[Male antifertility drugs and cell apoptosis].
Male antifertility drugs can induce contraception by interfering with spermatogenesis progression. Their action mechanism is correlated with the apoptosis of spermatogenic cells. This paper summarizes recent researches on the mechanism of male antifertility-drugs, including testosterone, gossypol, tamoxifen and triptolide, reviews their regulating effect on cell apoptosis and the expression of the key genes and proteins involved, and explores the significance of further researches on male antifertility drugs and cell apoptosis.
Zha
Shu-Wei
SW
Jiangsu Family Planning Research Institute, Nanjing, Jiangsu 210036, China. zhaji423@tom.com
Zha
Ji
J
Huang
Yu-Feng
YF
D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D020169:Caspases / Q000235:genetics / Q000378:metabolism; D003272:Contraceptive Agents, Male / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D006072:Gossypol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010616:Phenanthrenes / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology*
D003272:Contraceptive Agents, Male; D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; D013629:Tamoxifen; C001899:triptolide; D013739:Testosterone; D020169:Caspases; D006072:Gossypol