title: Synthesis of highly substituted 2,3-dihydro-1H-pyrrole derivatives via a tandem regioselective addition of nitrones to 1,3-enynes with subsequent rearrangement.
abstract: A novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole derivatives via a tandem regioselective addition with subsequent rearrangement.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India.
authors.forename: Sivaperuman
authors.initials: S
authors.lastname: Saravanan
authors.forename: Ismail Abulkalam
authors.initials: IA
authors.lastname: Azath
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Muthusubramanian
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis*; D000480:Alkynes / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry; D009589:Nitrogen Oxides / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis*
chemical_list: D000475:Alkenes; D000480:Alkynes; D001555:Benzene Derivatives; D009589:Nitrogen Oxides; D011758:Pyrroles; C015388:nitrones