title: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing: response to antiepileptic dual therapy.
abstract: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is included among trigeminal autonomic cephalalgias in the International Classification of Headache Disorders-2. Available literature suggests that it responds to anticonvulsants, particularly lamotrigine. However, management of partial responders is difficult and antiepileptic duo-therapy may be an answer to it. Nonetheless, to our knowledge, anticonvulsant combination has never been tried in partial responders to monotherapy. We are presenting a case of SUNCT that had overlapping symptoms with Short-lasting Unilateral Neuralgiform headache attacks with cranial Autonomic features and responded well only to the combination of lamotrigine with carbamazepine. However, lamotrigine had to be stopped as patient developed leucopenia and it resulted in partial recurrence of symptoms.
authors.affiliation: Department of Psychiatry, University College of Medical Sciences and GTB Hospital, Shahdara, New Delhi-110 095, India. guptaravi_2003@yahoo.co.in
authors.forename: Ravi
authors.initials: R
authors.lastname: Gupta
authors.forename: Manjeet S
authors.initials: MS
authors.lastname: Bhatia
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000188:drug therapy*; D002220:Carbamazepine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D007839:Functional Laterality / Q000502:physiology; D020773:Headache Disorders / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D008875:Middle Aged; D050798:SUNCT Syndrome / Q000150:complications / Q000188:drug therapy*; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D002220:Carbamazepine; D000077213:Lamotrigine