title: SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway.
abstract: Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA.
authors.affiliation: Department of Biochemistry and Molecular Biology, Basic Science Building, New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Jeanette H
authors.initials: JH
authors.lastname: Sutherland
authors.forename: Bokun
authors.initials: B
authors.lastname: Cheng
authors.forename: I-Fen
authors.initials: IF
authors.lastname: Liu
authors.forename: Yuk-Ching
authors.initials: YC
authors.lastname: Tse-Dinh
mesh_terms: D053903:DNA Breaks, Double-Stranded; D053904:DNA Breaks, Single-Stranded; D053837:DNA Cleavage; D004264:DNA Topoisomerases, Type I / Q000235:genetics / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D043211:Exodeoxyribonuclease V / Q000235:genetics / Q000378:metabolism*; D011938:Rec A Recombinases / Q000235:genetics; D013014:SOS Response, Genetics
chemical_list: D029968:Escherichia coli Proteins; D011938:Rec A Recombinases; D043211:Exodeoxyribonuclease V; C468322:exodeoxyribonuclease V, E coli; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II