Cytomorphometric and immunohistochemical comparison between central and peripheral giant cell lesions of the jaws.
OBJECTIVE
To determine whether cytomorphometric differences of multinucleated giant cells (MGCs) and CD68 reactivity of both MGCs and infiltrating macrophages may be associated with the clinical behavior of central and peripheral giant cell lesions of the jaws.


METHODS
Paraffin-embedded samples of central giant cell lesions (CGCLs; n = 20) and peripheral giant cell lesions (PGCLs; n = 20) were prepared for cytomorphometric analysis and immunohistochemistry.


RESULTS
The nuclei in CGCLs were more numerous, larger, and more irregular than those in PGCLs. Furthermore, CD68 expression and the ratio of CD68(+) macrophage to MGCs were significantly greater in CGCLs than in PGCLs. Statistical correlations between CD68 expression and the staining-intensity distribution score within the diagnostic groups were significant in CGCLs and not significant in PGCLs.


CONCLUSIONS
Although the CGCLs share some histopathologic similarities with PGCLs, differences in both nuclear morphometric parameters of MGC and CD68 immunoreactivity may underlie the distinct clinical behavior.
Flórez-Moreno
Gloria Amparo
GA
Department of Integrated Basic Studies, Medellín, Colombia.
Henao-Ruiz
Marcela
M
Santa-Sáenz
Diana Marcela
DM
Castañeda-Peláez
Diego Andrés
DA
Tobón-Arroyave
Sergio Iván
SI
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D002467:Cell Nucleus / Q000473:pathology; D048430:Cell Shape; D048429:Cell Size; D002648:Child; D005260:Female; D005882:Gingival Diseases / Q000378:metabolism / Q000473:pathology*; D006101:Granuloma, Giant Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D007571:Jaw Diseases / Q000378:metabolism / Q000473:pathology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule