title: Synthesis of curcumin mimics with multidrug resistance reversal activities.
abstract: In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.
authors.affiliation: College of Medicine, Kwandong University, Gangneung 210-701, Republic of Korea.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Um
authors.forename: Sungsik
authors.initials: S
authors.lastname: Cho
authors.forename: Ho Bum
authors.initials: HB
authors.lastname: Woo
authors.forename: Yong Kee
authors.initials: YK
authors.lastname: Kim
authors.forename: Hanna
authors.initials: H
authors.lastname: Kim
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
authors.forename: Su-Nam
authors.initials: SN
authors.lastname: Kim
authors.forename: Chan Mug
authors.initials: CM
authors.lastname: Ahn
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D003474:Curcumin