title: The prevalence of optic disc pits and their relationship to glaucoma.
abstract: OBJECTIVE
  To determine prevalence and associations of pits of the optic disc in an older population and assess their relationship to open-angle glaucoma.
  
  
  METHODS
  Population-based cross-sectional study.
  
  
  METHODS
  The Blue Mountains Eye Study examined 3654 persons (82.4% of permanent residents) aged over 48 years. Stereo-optic disc photographs were graded in a masked fashion.
  
  
  RESULTS
  Nine pits were found in 7 persons, a population prevalence of 0.19%. Three morphologic subtypes were found. Four peripheral pits were found at the inferior pole. Four central pits were located adjacent to the main vessel trunk. One pit was on the temporal disc margin. Pit prevalence increased with age (beta=0.0879, P=0.0099). It was strongly associated with high-pressure open-angle glaucoma [odds ratio (OR) 29, 95% confidence interval (95CI) 7-127], beta-peripapillary atrophy (OR 7.5, 95CI 2-32), and optic disc hemorrhage (OR 42, 95CI 9-183) after adjusting for age and sex. All peripheral pits were associated with paracentral visual field loss.
  
  
  CONCLUSIONS
  The classically described temporal optic disc pit was the rarest morphologic subtype found in this older population. Optic disc pits were primarily associated with glaucoma and the related signs of optic disc hemorrhage and beta-peripapillary atrophy. The previously reported optic disc pit association with low-tension glaucoma may represent acquisition bias.
authors.affiliation: Department of Ophthalmology, University of Sydney, Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Australia. PHealey@glaucoma.net.au
authors.forename: Paul R
authors.initials: PR
authors.lastname: Healey
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005124:Eye Abnormalities / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000453:epidemiology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D016017:Odds Ratio; D009898:Optic Disk / Q000002:abnormalities* / Q000473:pathology; D015995:Prevalence; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields