Treatment with rhBMP-2 of extreme radial bone atrophy secondary to fracture management in an Italian Greyhound.
rhBMP-2 solution on a collagen sponge was placed along the diaphysis of an atrophicradius, which had a history of recurring fractures. Two months after rhBMP-2 treatment, new mineralized bone was present, which significantly increased the diameter of the radius and allowed the removal of the external skeletal fixator (ESF). Due to carpo-metacarpal joint compromise, a pancarpal arthrodesis was performed seven months later. At follow-up evaluation two years later the dog was only very mildly lame.
Bernard
F
F
Surgery Unit, University College Dublin, Belfield, Dublin, Republic of Ireland. fabrice.bernard@ucd.ie
Furneaux
R
R
Adrega Da Silva
C
C
Bardet
J-F
JF
D020341:Absorbable Implants / Q000662:veterinary; D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D004285:Dogs / Q000293:injuries* / Q000601:surgery; D004343:Drug Implants / Q000627:therapeutic use; D005260:Female; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D011885:Radius Fractures / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D016896:Treatment Outcome; D014458:Ulna Fractures / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D016474:Weight-Bearing
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D004343:Drug Implants; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2