title: Tendon tissue engineering using scaffold enhancing strategies.
abstract: Tendon traumas or diseases are prevalent and debilitating lesions that affect the quality of life among populations worldwide. As a novel solution, tendon tissue engineering aims to address these lesions by integrating engineered, living substitutes with their native counterparts in vivo, thereby restoring the defective functions in situ. For such a purpose, competent scaffolding materials are essential. To date, three major categories of scaffolding materials have been employed: polyesters, polysaccharides, and collagen derivatives. Furthermore, with these materials as a base, a variety of specialized methodologies have been developed or adopted to enhance neo-tendogenesis. These strategies include cellular hybridization, interfacing improvement, and physical stimulation.
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Republic of Singapore.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: H S
authors.initials: HS
authors.lastname: Ramanath
authors.forename: Dong-An
authors.initials: DA
authors.lastname: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism / Q000627:therapeutic use; D018920:Coculture Techniques / Q000639:trends; D003094:Collagen / Q000378:metabolism / Q000627:therapeutic use; D003260:Contact Inhibition; D048091:Guided Tissue Regeneration / Q000639:trends*; D006801:Humans; D008422:Materials Testing; D010812:Physical Stimulation; D011091:Polyesters / Q000378:metabolism / Q000627:therapeutic use; D011134:Polysaccharides / Q000378:metabolism / Q000627:therapeutic use; D012038:Regeneration; D013708:Tendon Injuries / Q000628:therapy; D013710:Tendons / Q000473:pathology / Q000502:physiology*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds / Q000639:trends*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011134:Polysaccharides; D003094:Collagen