Effect of 1,3;1,6-beta-D-glucans on developing sea urchin embryos.
The effect of 1,3;1,6-beta-D-glucooligo- and polysaccharides with different structures (from 1 to 10 kDa of molecular mass; from 10-25% of beta-1,6-linked glucose residues content) on the developing embryos of sea urchin, Strongylocentrotus intermedius, was evaluated for the screening of potential positive stimulants. 1,3;1,6-beta-D-glucans with a molecular mass of between 6-10 kDa and at concentrations of 0.05-0.25 mg/ml shown the best modulator effect on the sea urchin embryos. 1,3;1,6-beta-D-glucans increased the survival of the sea urchin embryos up to 2.5-fold compared with the control animals.
Kiseleva
Marina I
MI
Laboratory of Enzymatic Chemistry, Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Academy of Sciences, Vladivostok, prospect 100-letya Vladivostoka, 159, Russian Federation.
Balabanova
Larissa A
LA
Rasskazov
Valery A
VA
Zvyagintseva
Tatiana N
TN
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D047269:Strongylocentrotus / Q000187:drug effects* / Q000196:embryology*; D016019:Survival Analysis; D013997:Time Factors; D047071:beta-Glucans / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D047071:beta-Glucans; C064197:beta-1,6-glucan; C033363:beta-1,3-glucan