title: Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells.
abstract: Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the ClogP values, were examined for their ability to induce apoptosis (through the DNA ladder fragmentation pattern), mitochondrial and cytoplasmic GSH depletion and NF-kappaB activation in murine lymphoblastic L1210 leukemia cells. A relationship between cytotoxic effect and a limited degree of lipophilicity was observed.
authors.affiliation: Departamentos de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, CP 476 Florianópolis, 88040-900 SC, Brazil.
authors.forename: Claudriana
authors.initials: C
authors.lastname: Locatelli
authors.forename: Rober
authors.initials: R
authors.lastname: Rosso
authors.forename: Maria C
authors.initials: MC
authors.lastname: Santos-Silva
authors.forename: Camila A
authors.initials: CA
authors.lastname: de Souza
authors.forename: Marley A
authors.initials: MA
authors.lastname: Licínio
authors.forename: Paulo
authors.initials: P
authors.lastname: Leal
authors.forename: Maria L
authors.initials: ML
authors.lastname: Bazzo
authors.forename: Rosendo A
authors.initials: RA
authors.lastname: Yunes
authors.forename: Tânia B
authors.initials: TB
authors.lastname: Creczynski-Pasa
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004952:Esters / Q000737:chemistry*; D005707:Gallic Acid / Q000737:chemistry* / Q000633:toxicity*; D057927:Hydrophobic and Hydrophilic Interactions; D007938:Leukemia / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007939:Leukemia L1210; D051379:Mice; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D004952:Esters; D016328:NF-kappa B; D005707:Gallic Acid