Chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type and bronchogenic adenocarcinoma.
We present the chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma and bronchogenic adenocarcinoma with bronchioloalveolar features. Using fluorescence in situ hybridization, we identified deletion of the immunoglobulin heavy chain gene in the lymphomatous component, but not the carcinomatous component. The presence of differing genetic compositions suggests a biclonal environment composed of 2 distinct neoplastic processes.
Cupp
John S
JS
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, UAS.
Wrede
Joanna E
JE
Cherry
Athena M
AM
Arber
Daniel A
DA
George
Tracy I
TI
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D002283:Carcinoma, Bronchogenic / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery; D020169:Caspases / Q000235:genetics; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis / Q000235:genetics; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000235:genetics; D009378:Neoplasms, Multiple Primary; D017384:Sequence Deletion
D007143:Immunoglobulin Heavy Chains; D009363:Neoplasm Proteins; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein