Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.
SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.
Kakeya
Hiroshi
H
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. kakeya@nagasaki-u.ac.jp
Miyazaki
Yoshitsugu
Y
Senda
Hisato
H
Kobayashi
Tsutomu
T
Seki
Masafumi
M
Izumikawa
Koichi
K
Yamamoto
Yoshihiro
Y
Yanagihara
Kazunori
K
Tashiro
Takayoshi
T
Kohno
Shigeru
S
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000382:microbiology; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D011090:Polyenes / Q000494:pharmacology* / Q000627:therapeutic use
D000935:Antifungal Agents; D011090:Polyenes; C115650:SPA S 843