A case of rhabdomyosarcoma masquerading as acute leukemia at presentation: a case report.
Non-hematopoietic malignancies infiltrating bone marrow have always been a source of erroneous diagnosis. Among these, the small round cell tumors like neuroblastomas and rhabdomyosarcomas mimick the hematopoietic blasts. Several case reports of rhabdomyosarcoma mimicking acute leukemia, clinically and morphologically at presentation have been reported in the literature. To the best of our knowledge such an entity has not been reported in Indian literature. We report here one such case of alveolar rhabdomyosarcoma masquerading as acute leukemia. A thorough clinical examination with high degree of suspicion on bone marrow morphology and judicious use of appropriate immunohistochemistry markers will solve many of these cases.
Srinivas
Upendra
U
Department of Hematology, All India Institute of Medical Sciences, New Delhi.
Pillai
Lakshmi
L
Kar
Rakhee
R
Mahapatra
Manoranjan
M
Gujra
Sumeet
S
Pati
Hara Prasad
HP
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology*; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D017570:MyoD Protein / Q000032:analysis; D018008:Myogenin / Q000032:analysis; D009195:Peroxidase / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D018232:Rhabdomyosarcoma, Alveolar / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology
D014408:Biomarkers, Tumor; D003893:Desmin; D017730:Ki-1 Antigen; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D018008:Myogenin; D009195:Peroxidase; D017493:Leukocyte Common Antigens; D010751:Phosphopyruvate Hydratase