Experimental models of abdominal aortic aneurysms: an overview.
In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons. The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.
Paraskevas
Kosmas I
KI
Department of Clinical Biochemistry (Vascular Disease Prevention Clinic), Royal Free Hospital and Royal Free Medical School, University College of London, Pond Street, London NW3 2QG, UK.
Mikhailidis
Dimitri P
DP
Perrea
Despina
D
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology* / Q000628:therapy*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D015607:Stents