Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects.
(-) Hydroxycitric acid (HCA), an active ingredient extracted from the Garcinia cambogia fruit rind, has been commonly used as a dietary supplement for weight management. Given the controversy over HCA related testicular toxicity in animal studies, we investigated changes in serum sex hormones levels as an extension of our previous double-blind placebo-controlled trial in human subjects, in which 44 participants received either G. cambogia extract (1667.3 mg/day equivalent to 1000 mg HCA/day) or placebo for 12 weeks. Compared to the placebo group, administration of the extract did not significantly alter the serum testosterone, estrone, and estradiol levels. Similarly, hematology, serum triacylglycerol and serum clinical pathology parameters did not reveal any significant adverse effects. The results of this preliminary investigation indicate that ingestion of G. cambogia extract at dose levels commonly recommended for human use does not affect serum sex hormone levels and blood parameters.
Hayamizu
Kohsuke
K
FANCL Research Institute, Kamishinano 12-13, Totsuka-ku, Yokohama, Japan. kohayamizu@fancl.co.jp
Tomi
Hironori
H
Kaneko
Izuru
I
Shen
Manzhen
M
Soni
Madhu G
MG
Yoshino
Gen
G
D000328:Adult; D000368:Aged; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004334:Drug Administration Schedule; D005260:Female; D029760:Garcinia / Q000737:chemistry*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*
D019440:Anti-Obesity Agents; D012739:Gonadal Steroid Hormones; D010936:Plant Extracts