Promoting physiological hypertrophy in the failing heart.
1. Heart failure rates have reached epidemic proportions in Western society. 2. New strategies proposed to improve cardiac function of the failing heart include regeneration, stem cell therapy, innovative methods for the revascularization of ischaemic cardiac tissue and the activation of signalling pathways that promote physiological growth (hypertrophy). 3. The insulin-like growth factor 1-phosphoinositide-3-kinase pathway is a well characterized regulator of physiological hypertrophy. 4. In this mini-review we present studies that suggest promoting physiological hypertrophy in the failing heart may be beneficial.
Pretorius
Lynette
L
Baker Heart Research Institute, and Faculty of Medicine, Nursing and Health Sciences, Department of Medicine (Alfred Hospital), Monash University, Melbourne, Victoria, Australia.
Owen
Kate L
KL
Jennings
Garry L
GL
McMullen
Julie R
JR
D006332:Cardiomegaly; D015444:Exercise; D006333:Heart Failure / Q000628:therapy*; D006801:Humans