A novel one-step method for the synthesis of C-5-substituted Omicron6,5'-cyclopyrimidine nucleoside analogues in ammonia water.
A novel one-step method for preparing C-5-substituted Omicron(6),5'-cyclopyrimidine nucleoside analogues is reported. This method employs molecular iodine to mediate the cyclization from the 5'-Omicron-hydroxyl group of the sugar ring and C-6 at the position of the nitrogen base in ammonia water under mild conditions without any other aprotic organic solvent.
Qu
Gui-Rong
GR
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, Henan, P R China.
Ren
Bo
B
Niu
Hong-Ying
HY
Mao
Zhi-Jie
ZJ
Guo
Hai-Ming
HM
D000641:Ammonia / Q000737:chemistry*; D003500:Cyclization; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D012996:Solutions; D014867:Water / Q000737:chemistry
D011741:Pyrimidine Nucleosides; D012996:Solutions; D014867:Water; D000641:Ammonia