title: A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response.
abstract: We have discovered functionalized multiwalled carbon nanotubes with reduced protein-binding, cytotoxicity, and immune response and the associated structure-activity relationships using in silico surface molecular diversity design, combinatorial library synthesis, and multiple biological screenings. Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research.
authors.affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Mu
authors.forename: Ningning
authors.initials: N
authors.lastname: Gao
authors.forename: Aifeng
authors.initials: A
authors.lastname: Liu
authors.forename: Yuehan
authors.initials: Y
authors.lastname: Xing
authors.forename: Sulian
authors.initials: S
authors.lastname: Gao
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guangbo
authors.initials: G
authors.lastname: Qu
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016208:Databases, Factual; D006801:Humans; D013058:Mass Spectrometry; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity* / Q000648:ultrastructure; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000276:immunology*
chemical_list: D011506:Proteins