title: Optic atrophy, necrotizing anterior scleritis and keratitis presenting in association with Streptococcal Toxic Shock Syndrome: a case report.
abstract: BACKGROUND
  We report a case of optic atrophy, necrotizing anterior scleritis and keratitis presenting in a patient with Streptococcal Toxic Shock Syndrome.
  
  
  METHODS
  A 43-year-old woman developed streptococcal toxic shock syndrome secondary to septic arthritis of her right ankle. Streptococcus pyogenes (b-haemolyticus Group A) was isolated from blood cultures and joint aspirate. She was referred for ophthalmology review as her right eye became injected and the pupil had become unresponsive to light whilst she was in the Intensive Therapy Unit (ITU). The iris appeared atrophic and was mid-dilated with no direct or consensual response to light. Three zones of sub-epithelial opacification where noted in the cornea. There where extensive posterior synechiae. Indirect ophthalmoscopy showed a pale right disc. The vision was reduced to hand movements (HM). A diagnosis of optic atrophy was made secondary to post-streptococcal uveitis. She subsequently developed a necrotizing anterior scleritis.
  
  
  CONCLUSIONS
  This case illustrates a previously unreported association of optic atrophy, necrotizing anterior scleritis and keratitis in a patient with post-streptococcal uveitis. This patient had developed Streptococcal Toxic Shock Syndrome secondary to septic arthritis. We recommend increased awareness of the potential risks of these patients developing severe ocular involvement.
authors.affiliation: Department of Ophthalmology, Mid Essex NHS Trust, Court Road, Chelmsford, UK. papageorgiouk@doctors.org.uk
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Papageorgiou
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Ioannidis
authors.forename: Petros S
authors.initials: PS
authors.lastname: Andreou
authors.forename: Ajay J
authors.initials: AJ
authors.lastname: Sinha