title: Effect of Gd-DTPA induCED susceptibility on single-point Dixon fat/water separation.
abstract: A single-point Dixon (SPD) fat/water separation method is proposed for breast dynamic contrast-enhanced MRI (DCE-MRI) in which field inhomogeneities and phase offsets measured prior to the injection of gadopentate dimeglumine (Gd-DTPA) are used to correct the postinjection images. A breast phantom study was conducted to demonstrate this technique, in which varying excess concentrations of Gd-DTPA (0-3 mM) were introduced into a 25-cm(3) breast lesion. The presence of excess Gd-DTPA in the lesion was found to create magnetic field perturbations of up to 0.35 microT per mM excess Gd-DTPA around the lesion. However, these perturbations had a negligible effect on the quality of the fat/water separation for Gd-DTPA concentrations in the range of, and exceeding, those observed in breast tumors following a standard 0.1 mmole/kg injection. Therefore, we conclude that the preinjection phase data is adequate for the correction of the postinjection images in breast exams.
authors.affiliation: Division of Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: Tamar
authors.initials: T
authors.lastname: Hoory
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ramsay
authors.forename: Donald B
authors.initials: DB
authors.lastname: Plewes
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000465:Algorithms; D016477:Artifacts; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014867:Water
chemical_list: D003287:Contrast Media; D014867:Water; D019786:Gadolinium DTPA