title: Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.
abstract: We hypothesized that heightened systemic inflammation contributes to the increased rate of cardiovascular events in HIV-infected patients not receiving combination antiretroviral therapy. We performed a pilot trial to assess the effects of the nuclear factor-kappaB inhibitor salsalate on flow-mediated dilation of the brachial artery, a measure of endothelial function. Flow-mediated dilation significantly improved after 8 weeks of salsalate. However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease.
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Samir K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Johnson
authors.forename: Chandan
authors.initials: C
authors.lastname: Saha
authors.forename: Kieren J
authors.initials: KJ
authors.lastname: Mather
authors.forename: Martha L
authors.initials: ML
authors.lastname: Greenwald
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Waltz
authors.forename: Jalees
authors.initials: J
authors.lastname: Rehman
authors.forename: Michael P
authors.initials: MP
authors.lastname: Dubé
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D001916:Brachial Artery / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000821:virology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010865:Pilot Projects; D012459:Salicylates / Q000009:adverse effects / Q000627:therapeutic use*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016328:NF-kappa B; D012459:Salicylates; C014182:salicylsalicylic acid