title: Lymphomatoid drug reaction secondary to methylphenidate hydrochloride.
abstract: Lymphomatoid drug reactions are relatively rare, with no gender, race, or age predilection. The condition generally may be divided into 2 broad categories with some overlap: (1) drug-induced pseudolymphoma and (2) anticonvulsant-induced pseudolymphoma syndrome, marked by the triad of papular to nodular skin lesions, fever, and lymphadenopathy. While a vast array of pharmacologic agents has been linked to lymphomatoid drug reactions, our case represents the first reported incidence of methylphenidate hydrochloride--a ubiquitously prescribed medication for attention deficit hyperactivity disorder--causing a pseudolymphoma.
authors.affiliation: Department of Dermatology, Drexel University College of Medicine, 219 N Broad Street, 4th Fl, Philadelphia, PA 19107, USA.
authors.forename: John Patrick
authors.initials: JP
authors.lastname: Welsh
authors.forename: Christine
authors.initials: C
authors.lastname: Ko
authors.forename: W Teresa
authors.initials: WT
authors.lastname: Hsu
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis; D008774:Methylphenidate / Q000009:adverse effects*; D019310:Pseudolymphoma / Q000139:chemically induced* / Q000175:diagnosis; D012867:Skin / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D000697:Central Nervous System Stimulants; D008774:Methylphenidate