Secondary metabolites from the mycelia of the fungus Monascus pilosus BCRC 38072.
Three new compounds, including two phenylacetic acid derivatives, monaspilosin (1) and monaspiloindole (2), and one pyranoindole alkaloid, monaspyranoindole (3), were isolated from the EtOAc-soluble fraction of the MeOH extract of the mycelia of Monascus pilosus BCRC 38072. Twelve known compounds were also obtained in this study. The structures were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. This is the first report of Monascus metabolites with an indole ring. All isolates were also evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in TLC autographic and spectroscopic assays.
Cheng
Ming-Jen
MJ
Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, Taiwan, Republic of China.
Wu
Ming-Der
MD
Chen
Ih-Sheng
IS
Yuan
Gwo-Fang
GF
D001713:Biphenyl Compounds; D003470:Culture Media; D000431:Ethanol; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D032741:Monascus / Q000737:chemistry* / Q000254:growth & development; D025282:Mycelium / Q000737:chemistry*; D010084:Oxidation-Reduction; D010648:Phenylacetates / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
D001713:Biphenyl Compounds; D003470:Culture Media; D016166:Free Radical Scavengers; D026121:Indole Alkaloids; D007211:Indoles; D010648:Phenylacetates; D010851:Picrates; D012997:Solvents; C528527:monaspiloindole; C528526:monaspilosin; C528528:monaspyranoindole; D000431:Ethanol; C004931:1,1-diphenyl-2-picrylhydrazyl