title: [Study of long-term toxicity on applying Solanum lyratum on rat skin].
abstract: OBJECTIVE
  To observe the long-term toxicity of rats which we had applied Solanum lyratum Thunb gel on their skins daily for 90 days.
  
  
  METHODS
  We had applied high and low doses of Solanum lyratum Thunb gel one time each day on healthy and punctured rats skins respectively for 90 days. The rats' characters were observed, and their blood routines, blood biochemistry index, anatomic and pathologic changes of their major organs were also detected.
  
  
  RESULTS
  Rats' characters had no change, the results of all detections were normal. There was no significant difference between test groups and control group. Rats'major organs had no change in anatomy and pathology.
  
  
  CONCLUSIONS
  No long-term toxic reaction can be found in the test of rats applied Solanum lyratum Thunb gel on their skins for a long term. It proves that it is safe using the normal dose of this gel on the skin in clinic.
authors.affiliation: Dermatology Department, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Xiang-yang
authors.initials: XY
authors.lastname: Su
authors.forename: Cai-hong
authors.initials: CH
authors.lastname: Qu
authors.forename: Gan-yuan
authors.initials: GY
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Lai
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005782:Gels; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D032322:Solanum / Q000737:chemistry*; D036401:Toxicity Tests, Chronic
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D005782:Gels