title: Cyclosporin effectively inhibits posterior capsule opacification after phacoemulsification in rabbits: a preliminary study.
abstract: OBJECTIVE
  To evaluate whether cyclosporin A prevents or reduce posterior capsule opacification after phacoemulsification surgery in rabbit eyes.
  
  
  METHODS
  Twenty rabbits underwent cataract surgery in their right eyes were randomized into two groups. In group 1, 0.1 mL cyclosporin A (0.5 mg/mL) was given into the capsular bag after phacoemulsification and 0.1 mL cyclosporin A (0.5 mg/mL) was injected subconjunctivally once every 3 days for 1 week. Group 2 served as a control group. The development of posterior capsule opacification was assessed weekly, its density was graded clinically, and the proliferation of lens epithelial cells was evaluated histologically.
  
  
  RESULTS
  On clinical assessment, cyclosporin A was significantly effective in preventing posterior capsule opacification compared with controls (P = 0.0045). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment group, in contrast to multilayer lens epithelial cells proliferation in the control group.
  
  
  CONCLUSIONS
  The preliminary results indicate that cyclosporin A is effective in suppressing posterior capsule opacification in rabbits, yet requires further investigation.
authors.affiliation: Department of Ophthalmology, Medical School, Fatih University, Ankara, Turkey.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Totan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yağci
authors.forename: Mesut
authors.initials: M
authors.lastname: Erdurmuş
authors.forename: Reyhan
authors.initials: R
authors.lastname: Bayrak
authors.forename: Ibrahim Feyzi
authors.initials: IF
authors.lastname: Hepşen
mesh_terms: D000818:Animals; D002386:Cataract / Q000209:etiology / Q000517:prevention & control*; D002387:Cataract Extraction / Q000009:adverse effects* / Q000379:methods*; D049109:Cell Proliferation / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D004847:Epithelial Cells / Q000473:pathology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007903:Lens Capsule, Crystalline / Q000473:pathology; D018918:Phacoemulsification / Q000009:adverse effects*; D011184:Postoperative Period; D011817:Rabbits
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine