title: Adolescent problem behaviours predicting DSM-IV diagnoses of multiple substance use disorder. Findings of a prospective birth cohort study.
abstract: BACKGROUND
  Whether there is an independent association between problem behaviours and substance use disorders (SUD) needs further investigation. This study examined prospective associations of adolescent psychopathology and problem behaviours with SUD in early adulthood, and whether these associations are confounded by other factors.
  
  
  METHODS
  Data were from a prospective study of 2,429 young Australian adults from birth to the age of 21 when data on SUD were collected. Adolescent psychopathology and behaviour were assessed at 14 years via the Youth Self Report instrument on eight sub-scales of emotional and behavioural problems.
  
  
  RESULTS
  In multivariate analyses, attention problems, delinquency, and aggression were associated with both single and multiple SUD in early adulthood, with delinquent behaviour being the strongest predictor (OR = 2.0, 95% CI 1.4-2.9 for one SUD and OR = 3.6, 95% CI 2.4-5.0 for multiple SUDs).
  
  
  CONCLUSIONS
  Problem behaviours, in particular delinquency and aggression in early adolescence predict long-term SUD. The results suggest that substance use prevention programs should target adolescents with early symptoms of psychopathology and problem behaviour.
authors.affiliation: QADREC, School of Population Health, The University of Queensland, Herston Road, Herston (QLD) 4006, Australia. m.hayatbakhsh@sph.uq.edu.au
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Hayatbakhsh
authors.forename: Jake Moses
authors.initials: JM
authors.lastname: Najman
authors.forename: Konrad
authors.initials: K
authors.lastname: Jamrozik
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al Mamun
authors.forename: William
authors.initials: W
authors.lastname: Bor
authors.forename: Rosa
authors.initials: R
authors.lastname: Alati
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology; D015331:Cohort Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007604:Juvenile Delinquency / Q000706:statistics & numerical data*; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*