Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.
Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). alpha(1)-Adrenoceptors (alpha(1)ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific alpha(1)AR subtypes in the treatment of LUTS.
Schwinn
Debra A
DA
Department of Anesthesiology, University of Washington, Seattle, Washington 98195-6540, USA. dschwinn@u.washington.edu
Roehrborn
Claus G
CG
D058668:Adrenergic alpha-1 Receptor Antagonists; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D053448:Prostatism / Q000188:drug therapy*; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification*
D058668:Adrenergic alpha-1 Receptor Antagonists; D018340:Receptors, Adrenergic, alpha-1