Pulse wave velocity is associated with metabolic syndrome components in CAPD patients.
BACKGROUND
Overall, the proportion of deaths due to cardiovascular disease (CVD) reached 40-50% in dialysis patients. Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and CVD risk. Individual components of the metabolic syndrome (MetS) are well-established cardiovascular risk factors. Thus we conducted a cross-sectional study in continuous ambulatory peritoneal dialysis (CAPD) patients to explore the association of MetS components with PWV.


METHODS
Prevalent CAPD patients (n = 148, 63 M/85 F) were categorized according to the number of traits of the MetS into one of three groups (No MetS, Risk of MetS, MetS). Due to the effect of peritoneal dialysis (PD), waist circumference was not assessed. Aortic stiffness was assessed by carotid-femoral PWV (C-F PWV).


RESULTS
Patients' MetS trait numbers were positively associated with C-F PWV (r = 0.301, p < 0.01), pulse pressure (r = 0.256, p < 0.01), systolic blood pressure (r = 0.233, p < 0.01), and serum albumin (r = 0.205, p < 0.05). In a multivariate regression analysis, PWV was independently determined by age (p < 0.01) and MetS score (p = 0.01). Adjusted R(2) of the model was 0.24.


CONCLUSIONS
MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients.
Zhe
Xing-wei
XW
Division of Nephrology, Peking University Third Hospital, Beijing, PR China.
Zeng
Jing
J
Tian
Xin-kui
XK
Chen
Wei
W
Gu
Yue
Y
Cheng
Li-tao
LT
Chen
Hui-min
HM
Axelsson
Jonas
J
Lindholm
Bengt
B
Wang
Tao
T
D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011674:Pulse; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin