A comparison of circulating TNF-alpha in obese and lean women with and without preeclampsia.
OBJECTIVE
We hypothesized that TNF-alpha would be higher in obese versus lean women with preeclampsia.


METHODS
Total plasma TNF-alpha was measured in a nested case-control study of 123 nulliparous lean and obese control women and women with preeclampsia.


RESULTS
Adjusted mean TNF-alpha concentrations were 0.97 +/- 0.11 (pg/mL +/- SEM) in lean controls, 1.01 +/- 0.10 in obese controls, 1.43 +/- 0.11 in lean women with preeclampsia and 1.16 +/- 0.11 in obese women with preeclampsia. Pregnancy outcome was the single predictor of TNF-alpha concentration in the general linear regression model (p = 0.04).


CONCLUSIONS
TNF-alpha concentration was higher in preeclampsia compared with control subjects. Obesity was not associated with higher TNF-alpha concentrations in either preeclampsia or control subjects.
Founds
Sandra A
SA
University of Pittsburgh School of Nursing, Pittsburgh, PA 15261, USA. safounds@comcast.net
Powers
Robert W
RW
Patrick
Thelma E
TE
Ren
Dianxu
D
Harger
Gail F
GF
Markovic
Nina
N
Roberts
James M
JM
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013851:Thinness / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D014409:Tumor Necrosis Factor-alpha