Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future.
New regenerative treatment strategies are being developed for intervertebral disc degeneration of which the implantation of various cell types is promising. All cell types used so far require in vitro expansion prior to clinical use, as these cells are only limited available. Adipose-tissue is an abundant, expendable and easily accessible source of mesenchymal stem cells. The use of these cells therefore eliminates the need for in vitro expansion and subsequently one-step regenerative treatment strategies can be developed. Our group envisioned, described and evaluated such a one-step procedure for spinal fusion in the goat model. In this review, we summarize the current status of cell-based treatments for intervertebral disc degeneration and identify the additional research needed before adipose-derived mesenchymal stem cells can be evaluated in a one-step procedure for regenerative treatment of the intervertebral disc. We address the selection of stem cells from the stromal vascular fraction, the specific triggers needed for cell differentiation and potential suitable scaffolds. Although many factors need to be studied in more detail, potential application of a one-step procedure for intervertebral disc regeneration seems realistic.
Hoogendoorn
R J W
RJ
Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands.
Lu
Z F
ZF
Kroeze
R J
RJ
Bank
R A
RA
Wuisman
P I
PI
Helder
M N
MN
D017667:Adipocytes / Q000637:transplantation*; D000818:Animals; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology / Q000503:physiopathology; D045164:Mesenchymal Stem Cell Transplantation / Q000639:trends*; D012038:Regeneration; D013122:Spinal Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D013123:Spinal Fusion / Q000639:trends; D023822:Tissue Engineering / Q000639:trends