On the role of granule yield strength for the compactibility of granular solids.
The objective of this article was to explore the relationship between mechanical properties of single granules and the evolution in tensile strength and tablet micro-structure. Granules of different expected deformation behavior were used as model materials. It is suggested that the role of plasticity in this context is twofold: firstly, to affect the rate of compactibility and thus the pressure range needed to reach the maximal attained tablet strength and, secondly, to affect the mode of deformation of the granules and thus the maximal attained tablet strength. A decrease in yield pressure of single granules increased the tablet tensile strength at a given compaction pressure. The yield pressure can be controlled by the granule composition and porosity.
Nordström
J
J
Department of Pharmacy, Uppsala University, P.O. Box 580, SE-75123 Uppsala, Sweden. josefina.nordstrom@farmaci.uu.se
Welch
K
K
Frenning
G
G
Alderborn
G
G
D002626:Chemistry, Pharmaceutical; D008422:Materials Testing; D011208:Powders; D013607:Tablets
D011208:Powders; D013607:Tablets