Children at high altitude have less nocturnal periodic breathing than adults.
Although children commonly travel to high altitudes, their respiratory adaptation to hypoxia remains elusive. Therefore, in the present study respiratory inductive plethysmography, pulse oximetry (S(p,O(2))) and end-tidal CO(2) tension (P(ET,CO(2))) were recorded in 20 pre-pubertal children (aged 9-12 yrs) and their fathers during 1 night in Zurich (490 m) and 2 nights at the Swiss Jungfrau-Joch research station (3,450 m) following ascent by train within <3 h. In children, mean+/-sd nocturnal S(p,O(2)) fell from 98+/-1% at 490 m to 85+/-4 and 86+/-4% at 3,450 m (nights 1 and 2, respectively); P(ET,CO(2)) decreased significantly from 37+/-6 to 32+/-3 and 33+/-4 mmHg (3,450 versus 490 m). In adults, changes in nocturnal S(p,O(2)) and P(ET,CO(2)) at 3,450 m were similar to those in children. Children spent less time in periodic breathing at 3,450 m during night 1 and 2 (8+/-11 and 9+/-13%, respectively) than adults (34+/-24 and 22+/-17%, respectively), and their apnoea threshold for CO(2) was lower compared with adults (27+/-2 and 30+/-2 mmHg, respectively, both nights). S(p,O(2)), P(ET,CO(2)) and time in periodic breathing at altitude were not correlated between children and their fathers. In conclusion, children revealed a similarly reduced nocturnal O(2) saturation and associated hyperventilation at high altitude as adults but their breathing pattern was more stable, possibly related to a lower apnoea threshold for CO(2).
Kohler
M
M
Pulmonary Division, Dept of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland.
Kriemler
S
S
Wilhelm
E M
EM
Brunner-LaRocca
H
H
Zehnder
M
M
Bloch
K E
KE
D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000503:physiopathology*; D001049:Apnea / Q000209:etiology / Q000503:physiopathology*; D001944:Breath Tests; D002648:Child; D015331:Cohort Studies; D005220:Fathers; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010991:Plethysmography; D017286:Polysomnography