Microwave promoted one-pot synthesis of novel A-ring fused steroidal dehydropiperazines.
The preparation of ring-A fused steroidal dehydropiperazine at the 3,4-position is herein described. The novel steroidal dehydropiperazines were prepared from the annulation reaction of ethylenediamine with 3-keto-4-en steroids in a one-pot reaction under microwave irradiation. The key step involves base catalysed aerial oxidation of the C-6 methylene group followed by cyclocondensation of ethylenediamine via Michael addition reaction.
Borthakur
Moyurima
M
Medicinal Chemistry Division, North-East Institute of Science and Technology, Jorhat-785006, India.
Barthakur
Madan G
MG
Boruah
Romesh C
RC
D002384:Catalysis; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
D005029:Ethylenediamines; D010879:Piperazines; D013256:Steroids; C031234:ethylenediamine