title: Epigenome-derived drugs: recent advances and future perspectives.
abstract: This review highlights the current knowledge of epigenetic targets of anticancer therapy and outlines the current limitations of epigenetic approaches and the difficulties in defining preventive tools and strategies. Promising strategies towards achieving the goal of developing effective epigenetic treatments are discussed, including restoration or enhancement of sensitivity to other treatment modalities, and combinations with other agents and new therapeutic areas.
authors.affiliation: Department of Molecular Biology, Medical Genetics Unit, University of Siena, Siena, Italy.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Vogiatzi
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Aimola
authors.forename: Maria Irene
authors.initials: MI
authors.lastname: Scarano
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Claudio
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents