A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.
Tanaka
Atsushi
A
Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
Youle
Richard J
RJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008564:Membrane Potentials; D008869:Microtubule-Associated Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000235:genetics / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism
D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051028:bcl-2-Associated X Protein; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; D034281:Dynamins