The role of candidal histolytic enzymes on denture-induced stomatitis in patients living in retirement homes.
METHODS
Fifty nine elders wearing complete dentures and living in retirement homes in Curitiba (southern Brazil), were divided into two groups: group #1, 26 patients with denture-induced stomatitis and group #2, 33 patients without denture-induced stomatitis. The two groups were evaluated in relation to the degree of denture-induced stomatitis, salivary fungal loads, and secretion of some histolytic enzymes.


RESULTS
Patients from group #1 showed higher degrees of colonisation by Candida albicans (p = 0.031). Candida krusei, Candida tropicalis, and Candida parapsilosis were also isolated, but there were no differences between the groups (p > 0.05). Secretory aspartyl protease (Sap) and chondroitinase did not show significant differences among the isolated Candida spp. in the two groups. Phospholipase secretion rates were higher among the strains of C. albicans from group #2 (p = 0.036). The same behaviour was not detected for non-albicans Candida species.


CONCLUSIONS
The results could infer that differences in the secretion rates of candidal histolytic enzymes should not be imputed as imperative for the progress of denture-induced stomatitis.
Thiele
Magna Carvalho de Menezes
MC
Laboratory of Stomatology, Faculty of Dentistry, Pontifical Catholic University of Paraná, Curitiba, Brazil.
Carvalho
Alessandra de Paula E
Ade P
Gursky
Lauren Christine
LC
Rosa
Rosimeire Takaki
RT
Samaranayake
Lakshman Perera
LP
Rosa
Edvaldo Antonio Ribeiro
EA
D000368:Aged; D016282:Aspartic Acid Endopeptidases / Q000032:analysis; D002175:Candida / Q000145:classification / Q000201:enzymology*; D002176:Candida albicans / Q000201:enzymology; D041022:Candida tropicalis / Q000201:enzymology; D002810:Chondroitinases and Chondroitin Lyases / Q000032:analysis; D015169:Colony Count, Microbial; D003824:Denture, Complete / Q000382:microbiology; D005260:Female; D005656:Fungal Proteins / Q000502:physiology*; D006707:Homes for the Aged; D054884:Host-Pathogen Interactions; D006801:Humans; D006867:Hydrolases / Q000032:analysis / Q000502:physiology*; D008297:Male; D010740:Phospholipases / Q000032:analysis; D012179:Retirement; D012463:Saliva / Q000382:microbiology; D012737:Sex Factors; D013282:Stomatitis, Denture / Q000382:microbiology*; D014774:Virulence
D005656:Fungal Proteins; D006867:Hydrolases; D010740:Phospholipases; D016282:Aspartic Acid Endopeptidases; D002810:Chondroitinases and Chondroitin Lyases