title: New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm.
abstract: Three new compounds: 2R,3R-pterosin L 3-O-beta-D-glucopyranoside (1), beta-D-xylopyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (2) and 4-O-benzoyl-beta-D-xylo-pyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (3), together with nine known compounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated from natural sources for the first time. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. tony_chen72001@yahoo.com.tw
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Hsieh
authors.forename: Ming-Jiuan
authors.initials: MJ
authors.lastname: Wu
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Du
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D002247:Carbon Isotopes; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D032495:Pteris / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D002247:Carbon Isotopes; D005960:Glucosides; D007189:Indans; D011522:Protons; D012717:Sesquiterpenes; C010772:pterosin; C586064:pterosin B