Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae.
Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.
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Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti Foundation, University of Rome La Sapienza, 5 00185 Rome, Italy.
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D049069:ATP-Dependent Proteases; D000251:Adenosine Triphosphatases / Q000235:genetics / Q000502:physiology; D017209:Apoptosis; D005144:F Factor / Q000235:genetics / Q000502:physiology; D044783:F-Box Proteins / Q000235:genetics / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000235:genetics / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000502:physiology; D009154:Mutation; D018384:Oxidative Stress; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology
D044783:F-Box Proteins; C464859:FIS1 protein, S cerevisiae; C481653:Mdm30 protein, S cerevisiae; D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins; D049069:ATP-Dependent Proteases; C082702:YME1 protein, S cerevisiae; D000251:Adenosine Triphosphatases; D020558:GTP Phosphohydrolases; C094774:DNM1 protein, S cerevisiae