Modular RNA heats up.
In this issue of Molecular Cell, Mariner et al. (2008) demonstrate that Alu RNA from a human SINE represses RNA polymerase II transcription during heat shock. This noncoding RNA is the first example of a "protein-like" transcription factor with a distinct modular architecture.
Shamovsky
Ilya
I
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.
Nudler
Evgeny
E
D000818:Animals; D018869:Heat-Shock Response / Q000502:physiology; D006801:Humans; D009690:Nucleic Acid Conformation; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020086:Short Interspersed Nucleotide Elements / Q000235:genetics*; D014158:Transcription, Genetic
D022661:RNA, Untranslated; D012319:RNA Polymerase II