title: Protective effect of lignans against sepsis from the roots of Saururus chinensis.
abstract: In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saururus chinensis, twelve lignans, sarisan (1), erythro-austrobailignan-6 (2), meso-dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-alpha (TNF-alpha) and alanine aminotransferase (ALT) activity in mice administered LPS/D-GalN.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Yeun-Kyung
authors.initials: YK
authors.lastname: Lee
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Jung
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Dong-Keun
authors.initials: DK
authors.lastname: Song
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004195:Disease Models, Animal; D017705:Lignans / Q000302:isolation & purification / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D032134:Saururaceae / Q000737:chemistry*; D018805:Sepsis / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology
chemical_list: D016207:Cytokines; D017705:Lignans; D008070:Lipopolysaccharides; D010936:Plant Extracts; C482199:lipopolysaccharide, E coli O55-B5; D000410:Alanine Transaminase