Coexistence of the antiphospholipid syndrome and abdominal aortic aneurysm.
The antiphospholipid syndrome is characterized by recurrent fetal loss, venous and/or arterial thrombosis, and thrombocytopenia associated with elevated titers of lupus anticoagulant and anticardiolipin antibodies. Although thrombosis is the characteristic vascular involvement in APS, the development of vascular aneurysms in patients with APS has been reported. We describe four patients with established APS who developed abdominal aortic aneurysm, and review the literature on previous published cases of arterial aneurysms developing in patients with APS. In addition, we discuss the possible pathophysiological association between APS and the development of this vascular abnormality.
Szyper-Kravitz
Martine
M
Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
Altman
Arie
A
de Carvalho
Jozélio Freire
JF
Bellisai
Francesca
F
Galeazzi
Mauro
M
Eshet
Yael
Y
Shoenfeld
Yehuda
Y
D000368:Aged; D016736:Antiphospholipid Syndrome / Q000150:complications*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D001323:Autoantibodies / Q000097:blood; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008875:Middle Aged; D011859:Radiography
D001323:Autoantibodies; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor