Chromosome segregation: centromeres get bent.
Work over the last several decades has shown that kinetochores play an active part in chromosome segregation, while the chromatin and, more to the point, the DNA have gathered little attention. In two intriguing papers, the Bloom and Khodjakov groups show that intercentromeric chromatin plays a much more active part in chromosome segregation than previously suspected.
Dorn
Jonas F
JF
Department of Pathology and Cell Biology, Université de Montreal, Montréal, Quebec H3C 3J7, Canada.
Maddox
Paul S
PS
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002503:Centromere / Q000502:physiology*; D002843:Chromatin / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D020090:Chromosome Segregation / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D000097722:Cohesins