N-myristoyltransferase: a novel target.
Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid, myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for anticancer, antiviral and antifungal agents. Recent N-myristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.
Prasad
K K
KK
Department of Pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Sector-8, C.B.D., Belapur, Navi Mumbai-400614, India.
Toraskar
M P
MP
Kadam
V J
VJ
D000217:Acyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D000977:Antiparasitic Agents / Q000378:metabolism / Q000494:pharmacology; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D012680:Sensitivity and Specificity
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D000998:Antiviral Agents; D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase