title: A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage.
abstract: OBJECTIVE
  This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results.
  
  
  METHODS
  A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected in organized screening to treatment either (1) if they were positive in a repeat Papanicolaou test smear and/or a human papillomavirus test or (2) if they were positive in the repeat Papanicolaou test smear test only. Women who tested positive were treated, regardless of colposcopic findings.
  
  
  RESULTS
  There were 208 of 337 (62%) women who were treated in the human papillomavirus /Papanicolaou test smear group (187/337 because of HPV positivity) and 138 of 337 (41%) in the Papanicolaou test smear only group. Histopathologically diagnosed cervical intraepithelial neoplasia grade 2 or worse was found among 112 of 337 (33.2%) women in the human papillomavirus/Papanicolaou test smear group compared with 85 of 337 (25.2%) women in the Papanicolaou test smear only group (P < .05). Twenty-one women with cervical intraepithelial neoplasia 2+ had normal colposcopy.
  
  
  CONCLUSIONS
  For adequate cervical intraepithelial neoplasia 2+ sensitivity, the decision to use loop electrosurgical excision procedure needs to be based on human papillomavirus testing results and should not exclude women with normal colposcopy.
authors.affiliation: Department of Obstetrics and Gynecology, Central Hospital, Karlstad, Sweden.
authors.forename: Pontus
authors.initials: P
authors.lastname: Bjerre
authors.forename: Lena
authors.initials: L
authors.lastname: Silfverdal
authors.forename: Lena
authors.initials: L
authors.lastname: Dillner
authors.forename: Björn
authors.initials: B
authors.lastname: Hagmar
authors.forename: Henrik
authors.initials: H
authors.lastname: Edvardsson
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
authors.forename: Agneta
authors.initials: A
authors.lastname: Andersson-Ellström
mesh_terms: D000328:Adult; D000465:Algorithms; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery / Q000821:virology; D003127:Colposcopy; D004598:Electrosurgery / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000302:isolation & purification*; D016896:Treatment Outcome; D014218:Triage; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery* / Q000821:virology