Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.
Biron
Eric
E
CIPS at Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747-Garching, Germany.
Chatterjee
Jayanta
J
Ovadia
Oded
O
Langenegger
Daniel
D
Brueggen
Joseph
J
Hoyer
Daniel
D
Schmid
Herbert A
HA
Jelinek
Raz
R
Gilon
Chaim
C
Hoffman
Amnon
A
Kessler
Horst
H
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D018938:Caco-2 Cells; D006801:Humans; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D013004:Somatostatin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*
D013004:Somatostatin