[Cervical-uterine-cancer associated factors in Nayarit state, Mexico].
OBJECTIVE
To establish the association between high-grade intraepithelial lesions and cervical-uterine-cancer, and the infection by human papillomavirus, genetic antecedents, socioeconomics, sexual behavior and gynecology and obstetrics factors in women of the State of Nayarit, Mexico.


METHODS
With a case-control design were studied 66 cases of high-grade intraepithelial lesions and cervical-uterine-cancer, and 132 controls. The information upon the risk factors was obtained by the application of a structured questionnaire. Polymerase Chain Reaction executed the virus identification. In the statistical analysis the association was obtained by odds ratio. The statistical significance was evaluated by the chi-square-Fisher and Student t tests, and multivariate logistic regression was used to explain the factors' influence.


RESULTS
In women with high-risk squamous intraepithelial lesions and cervical-uterine-cancer, the most frequently high-risk human papillomavirus found were: 18, 35, 58, 16, 31, 33 and 51.


CONCLUSIONS
Familial data of cervical-uterine-cancer, socioeconomic level, number of sexual partners, data of sexual transmitted diseases, and infection due to human papillomavirus 18 and 35 are the factors related to high-risk squamous intraepithelial lesions and cervical-uterine-cancer.
Aguirre Hernández
Raúl
R
Universidad Autónoma de Nayarit, México.
Medina Carrillo
Leopoldo
L
Montoya Fuentes
Héctor
H
Sandoval López
José Guadalupe
JG
Padilla Rosas
Miguel
M
García Silva
Valentín
V
Jáuregui Martínez
Armando
A
D000328:Adult; D000368:Aged; D002391:Catchment Area, Health; D005260:Female; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010212:Papilloma / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000209:etiology*