title: Synthesis of vinyl-functionalized oxazoles by olefin cross-metathesis.
abstract: A ruthenium-based catalyzed olefin cross-methathesis reaction involving 2- and 4-vinyl-functionalized oxazoles was developed. A wide range of olefinic partners was coupled in good to excellent yields and high stereoselectivities under mild conditions. This methodology offers new opportunities for the synthesis of a plethora of biologically active natural products.
authors.affiliation: Laboratoire de Chimie Organique, ESPCI, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hoffman
authors.forename: James H
authors.initials: JH
authors.lastname: Rigby
authors.forename: Stellios
authors.initials: S
authors.lastname: Arseniyadis
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D010080:Oxazoles; D014753:Vinyl Compounds; D012428:Ruthenium