Effect of growth hormone on Cyclooxygenase-2 expression in the hippocampus of rats chronically exposed to ozone.
The aim of this study was to determine GH-effects on Cyclooxygenase-2 (COX-2) expression on hippocampus alterations caused by ozone exposure. Seventy male rats were divided into: (1) control; (2) exposed to ozone for 7, 15, and 30 days; (3) exposed to ozone and treated with GH, for 7, 15, and 30 days. Results showed that lipoperoxidation levels and number of COX-2-positive cells increased in all groups exposed to ozone compared to control. In the groups treated with GH, COX-2 immunoreactive cell number decreased with respect to the ozone group. Therefore, GH could provide protection against damage induced by oxidative stress.
Martínez-Canabal
Alonso
A
Physiology Department, School of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico DF.
Angoa-Pérez
Mariana
M
Rugerio-Vargas
Concepción
C
Borgonio-Perez
Gabino
G
Rivas-Arancibia
Selva
S
D000818:Animals; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D010126:Ozone / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D010126:Ozone; D013006:Growth Hormone; D051546:Cyclooxygenase 2