Etiological analysis of initial colonization of periodontal pathogens in oral cavity.
It is unclear when the initial colonization by periodontal pathogens occurs in the oral cavity. Therefore, we report here the association between specific age groups and the time when the initial colonization by periodontal pathogens occurs in the oral cavity in such groups. Findings are based on an epidemiological analysis of the prevalence of five periodontal pathogens in the oral cavities of a wide range of age populations, from newborn to elderly, who were randomly selected in a geographic region of Brazil. These periodontal pathogens include Campylobacter rectus, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythia and were analyzed in the bacterial samples isolated from gingival sulcus, the dorsum of the tongue, and cheek mucosa of diverse age groups, using a bacterial DNA-specific PCR method. Results indicated that there are distinct age-related groups where initial colonization by the five periodontal pathogens examined in this study can be detected and that the presence of teeth is a permissive factor for colonization by P. gingivalis, P. intermedia, and T. forsythia. Although it remains unclear exactly how or when target pathogens colonize healthy subjects, an understanding of age-related groups does provide a potentially useful tool in the early detection and prevention of periodontitis in healthy individuals.
Cortelli
Jose Roberto
JR
Rua Nelson Freire Campelo, 343, Jardim Eulália, Taubaté, São Paulo, Cep 12010-700, Brazil. jrcortelli@uol.com.br
Aquino
Davi Romeiro
DR
Cortelli
Sheila Cavalca
SC
Fernandes
Camila Borges
CB
de Carvalho-Filho
Jonas
J
Franco
Gilson César Nobre
GC
Costa
Fernando Oliveira
FO
Kawai
Toshihisa
T
D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002167:Campylobacter / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D005881:Gingiva / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D009061:Mouth Mucosa / Q000382:microbiology; D010510:Periodontal Diseases / Q000453:epidemiology* / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000302:isolation & purification*; D015995:Prevalence; D018713:Prevotella intermedia / Q000302:isolation & purification*; D014059:Tongue / Q000382:microbiology