Flavonoids and related compounds in parasitic disease control.
Flavonoids are natural plant compounds increasingly used in therapeutic applications. Their large spectrum of activities depends on their structures and cellular targets. Most recent research shows they are promising drugs for controlling human and animal parasitic diseases. Their multiple effects make it difficult to understand their modes of action, but some of them have been elucidated. This review also deals with their toxicity in mammals.
Kerboeuf
D
D
INRA, Animal Infectiology and Public Health (UR-1282, IASP), (Multiresistances and antiparasitic drugs) team, F-37380 Nouzilly, France. kerboeuf@tours.inra.fr
Riou
M
M
Guégnard
F
F
D000818:Animals; D056890:Eukaryota / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006376:Helminths / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000378:metabolism; D010272:Parasitic Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D005419:Flavonoids