title: Long-term control of cystoid macular oedema in noninfectious uveitis with Mycophenolate Mofetil.
abstract: OBJECTIVE
  To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU).
  
  
  METHODS
  The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics, best corrected visual acuity (BCVA), fluorescein angiography (FA), and optical coherence tomography (OCT) findings were evaluated.
  
  
  RESULTS
  There were eight females and 11 males with a mean age of 32.9 +/- 8.9 years. After a 1-year follow-up, 18/19 patients (31 eyes, 96.9%, P < 0.05) no longer had signs of CMO, as per their FA and OCT findings; the mean central foveal thickness (CFT) was 167.2 +/- 12.8 microm. At the last follow-up, only 3/19 patients, all affected by Behçet panuveitis, had recurrences of CMO. Mean BCVA improved from 0.34 +/- 0.14 SD at baseline to 0.65 +/- 0.2 SD at last follow-up.
  
  
  CONCLUSIONS
  MMF was safe and effective in controlling CMO and in reducing the uveitis relapse rate in patients not responding to traditional immunosuppressants. Further case-controlled studies are mandatory to validate those preliminary results.
authors.affiliation: Neuroscience Department, Ophthalmology Section, Polytechnic University of Marche, Via Tronto 10, Torrette, Ancona, Italy. doctor_blacks@hotmail.com
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Neri
authors.forename: Cesare
authors.initials: C
authors.lastname: Mariotti
authors.forename: Luca
authors.initials: L
authors.lastname: Cimino
authors.forename: Lucia
authors.initials: L
authors.lastname: Mercanti
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giovannini
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008269:Macular Edema / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011241:Prednisone / Q000008:administration & dosage; D013995:Time; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D011241:Prednisone; D008775:Methylprednisolone