Light-chain amyloidosis with echocardiographic features of hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy and cardiac amyloidosis result in thickening of the left ventricle, as visualized by 2-dimensional echocardiography. Hemodynamically, hypertrophic cardiomyopathy can be typified by a left ventricular outflow tract gradient and systolic anterior motion of the mitral apparatus, findings rarely seen in cardiac amyloidosis. This case series reports 4 patients with cardiac light-chain amyloidosis and left ventricular outflow tract obstruction at rest, suggesting that there may be echocardiographic overlap between these 2 disparate disease processes. In a series of consecutive patients with cardiac light-chain amyloidosis over a 2-year period, the prevalence of these echocardiographic findings was approximately 4%. In conclusion, awareness of this overlap in echocardiographic presentation may permit more accurate diagnosis, particularly at early stages of amyloid disease, when more treatment options exist.
Dinwoodey
Danya L
DL
Section of Cardiology, Department of Medicine, Boston Medical Center, Boston, MA, USA.
Skinner
Martha
M
Maron
Martin S
MS
Davidoff
Ravin
R
Ruberg
Frederick L
FL
D000368:Aged; D000686:Amyloidosis / Q000150:complications*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000000981:diagnostic imaging*; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006331:Heart Diseases / Q000150:complications*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007147:Immunoglobulin Light Chains; D008297:Male; D008875:Middle Aged; D012146:Rest; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology; D014694:Ventricular Outflow Obstruction / Q000150:complications / Q000000981:diagnostic imaging*
D007147:Immunoglobulin Light Chains