Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients.
The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P=0.004 and P=0.003, and P=0.01 and P=0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P=0.01 and P=0.02, respectively).
Joe
Keun-Ho
KH
Department of Social Welfare with Addiction Rehabilitation, Eulji University, 143-5, Yangji-Dong, Sungnam, Kyounggi-do 461-713, Republic of Korea.
Kim
Dai-Jin
DJ
Park
Byung Lae
BL
Yoon
Sujung
S
Lee
Hae-Kook
HK
Kim
Tae-Suk
TS
Cheon
Young-Hoon
YH
Gwon
Do-Hoon
DH
Cho
Sung-Nam
SN
Lee
Hye Won
HW
Namgung
Suk
S
Shin
Hyoung Doo
HD
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000235:genetics*; D001007:Anxiety / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*
D017448:Receptors, Dopamine D2