title: Intron mis-splicing: no alternative?
abstract: A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA. scottwroy@gmail.com
authors.forename: Scott William
authors.initials: SW
authors.lastname: Roy
authors.forename: Manuel
authors.initials: M
authors.lastname: Irimia
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D016678:Genome; D006801:Humans; D007438:Introns / Q000235:genetics*; D020871:RNA Stability; D017381:Spliceosomes; D014158:Transcription, Genetic