Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line.
A small library of 2-indolinone derivatives with the 2,6-dichlorophenyl ring at the N(1) position and with varying substitutions including aryl groups at the 3-position were synthesized, and their structures were confirmed by spectral analysis. All molecules were screened for their in vitro cytotoxic activity on SW620 colon cancer cell lines. Among the designed series compounds 4c, 4f and 4j were found to be active at concentrations of 2-15 microg/ml. Some 3D-QSAR models were also built to understand the structure-activity relationship.
Virsodia
Vijay
V
Jubilant Organosys, 1A, Sector 16-A, Noida 201 301, Uttar Pradesh, India.
Manvar
Atul
A
Upadhyay
Kuldip
K
Loriya
Rajesh
R
Karia
Denish
D
Jaggi
Manu
M
Singh
Anu
A
Mukherjee
Rama
R
Shaikh
Mushtaque S
MS
Coutinho
Evans C
EC
Shah
Anamik
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D021281:Quantitative Structure-Activity Relationship; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D007211:Indoles