[Churg-Strauss syndrome].
Churg-Strauss syndrome is a systemic ANCA-associated vasculitis arising almost exclusively in patients with a pre-existent asthma. Common clinical manifestations are marked blood eosinophilia, asthma, chronic sinusitis, cardiomyopathy, pulmonary infiltrates, gastrointestinal complaints and a multiplex neuropathy. The morphological substrate is an eosinophilic necrotizing vasculitis. Other eosinophilic disorders such as parasitic diseases, allergies and idiopathic hyper-eosinophilic syndrome have to be excluded. The mainstay of therapy is high-dose corticosteroids with the addition of cytotoxic drugs in patients with poor prognosis.
Zwerina
J
J
Medizinische Klinik 3 mit Rheumatologie und Klinischer Immunologie, Universität Erlangen-Nürnberg, Erlangen, Deutschland. jochen.zwerina@uk-erlangen.de
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D003603:Cytotoxins / Q000627:therapeutic use*; D005858:Germany; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D003603:Cytotoxins