Lactate, with oxygen, incites angiogenesis.
Lactate has been reconsidered! As we now know, most is produced aerobically We report that lactate accumulation commonly occurs in the presence of oxygen and is sufficient to instigate signals for angiogenesis and connective tissue deposition. These include vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF beta), interleukin-1 (IL-1), and hypoxia-inducible factor (hif-1alpha). This paper, a mini-review, is occasioned by new data showing increased presence of VEGF and angiogenesis in an oxygenated site by adding a slow-release source of lactate into Matrigel and implanting the Matrigel subcutaneously in mice.
Hunt
Thomas K
TK
Department of Surgery, University of California Medical Center, San Francisco, CA 94143, USA.
Aslam
Rummana
R
Hussain
Zamir
Z
Beckert
Stefan
S
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D004338:Drug Combinations; D007375:Interleukin-1 / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D007797:Laminin / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D010100:Oxygen / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D001672:Biocompatible Materials; D004338:Drug Combinations; D007375:Interleukin-1; D007773:Lactates; D007797:Laminin; D011509:Proteoglycans; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; C059485:matrigel; D003094:Collagen; D010100:Oxygen