Adipose cell-adrenal interactions: current knowledge and future perspectives.
The central role of adipose tissue in the development of cardiovascular and metabolic pathology has been highlighted by the discovery of mediators (adipokines) secreted by adipose tissue and their involvement in the regulation of various biological processes. In light of recent experimental data, cross-talk between adipose tissue and the adrenal gland, particularly via the mineralocorticoid aldosterone, has been proposed. Aldosterone can induce adipogenesis, and human white adipose tissue is reported to release as-yet-uncharacterized factors that stimulate adrenocortical steroidogenesis and aldosterone production. These data could provide new insights into the pathophysiology of obesity-related disorders, including hypertension and aldosterone excess, with further studies necessary for confirming and better defining such adipose-adrenal interactions.
Ronconi
Vanessa
V
Division of Endocrinology, Università Politecnica delle Marche, 60020 Ancona, Italy.
Turchi
Federica
F
Bujalska
Iwona J
IJ
Giacchetti
Gilberta
G
Boscaro
Marco
M
D000273:Adipose Tissue / Q000502:physiology*; D000311:Adrenal Glands / Q000502:physiology*; D002450:Cell Communication; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D008901:Mineralocorticoids / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*
D008901:Mineralocorticoids