title: Radioprotective properties of eckol against ionizing radiation in mice.
abstract: We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients.
authors.affiliation: Department of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690-756, South Korea.
authors.forename: Eunjin
authors.initials: E
authors.lastname: Park
authors.forename: Gin-nae
authors.initials: GN
authors.lastname: Ahn
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
authors.forename: Jeong Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Yun
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Myung Bok
authors.initials: MB
authors.lastname: Wie
authors.forename: Young Jae
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Youngheun
authors.initials: Y
authors.lastname: Jee
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D049109:Cell Proliferation / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D004147:Dioxins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects
chemical_list: D004147:Dioxins; D011837:Radiation-Protective Agents; C060311:eckol