Mammary development in the embryo and adult: a journey of morphogenesis and commitment.
Mammary gland development occurs through distinctive stages throughout embryonic and pubertal development and reproductive life. At each stage, different signals are required to induce changes in both the epithelium and the surrounding mesenchyme/stroma. Recent studies have provided new insights into the origin, specification and fate of mammary stem and progenitor cells and into how the differentiated lineages that comprise the functional mammary gland are determined. The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells.
Watson
Christine J
CJ
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. cjw53@cam.ac.uk
Khaled
Walid T
WT
D000818:Animals; D019521:Body Patterning; D004847:Epithelial Cells / Q000166:cytology; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology / Q000196:embryology* / Q000254:growth & development* / Q000502:physiology; D051379:Mice; D009024:Morphogenesis; D011247:Pregnancy; D012098:Reproduction; D012741:Sexual Maturation; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology