[Effects of Lycium barbarum on the behavior, body weight and TNF-alpha level of rat treated with binding].
OBJECTIVE
To explore the effects of Lycium barbarum (L) on the behavior and body weight and TNF-alpha level of rat treated with binding.


METHODS
Rats were randomly divided into 6 groups: control group,binding group, 2.5% L group, 5.0% L group, 2.5% L plus binding group, 5.0% L plus binding group. Lycium barbarums were pressed into juice, then rats were fed with the drinking water contening juice. Rats were bound to restrict for 21 days.


RESULTS
(1) The increases of serum-cortisol level and the decreases of body weight and the increases of TNF-alpha level of rats of binding group in comparision with control groups (P < 0.05) (2) Rats body weight gain, movement and TNF-alpha level in both of 2.5% L plus binding group and 5.0% L plus binding group were more higher than those in binding group (P < 0.05). Serum-cortisol level of these two groups were more lower and had statistical significance in comparison with those of binding groups (P < 0.05).


CONCLUSIONS
Binding could suppress body weight gain and markedly reduce the activity and TNF-alpha level of rat. Lycium barbarum could be a good adjustment on the behavior, body weight and TNF-alpha.
Li
Honghui
H
Department of Environmental Health, Ningxia Medical College, Yinchuan 750004, China. lihh31@sina.com
Liu
Xiufang
X
Yang
Huifang
H
Zhu
Lingqin
L
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood; D032305:Lycium / Q000737:chemistry*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013315:Stress, Psychological; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D006854:Hydrocortisone