The role of intralesional Pingyangmycin in the treatment of venous malformation of facial and maxillary region.
OBJECTIVE
To investigate the effect of intralesional Pingyangmycin injection in venous malformation of facial and maxillary region.


METHODS
From September 2001 to October 2004, 82 patients were referred with venous malformation for intralesional Pingyangmycin injection.


RESULTS
After a minimum follow-up of 2 years, 67 patients (81.7%) developed 76-100% regression in their lesions; 12 patients (14.6%) had 51-75% regression in their lesion; 3 patients underwent surgical excision for the residual swellings. No changes in renal function or cytopenias were encountered. No patients developed chest X-ray changes during the course of therapy. There were no mortalities.


CONCLUSIONS
Intralesional injection of Pingyangmycin is an effective, inexpensive, and safe method in venous malformation of facial and maxillary region. We now favor Pingyangmycin sclerotherapy before considering surgical excision in all cases of venous malformation in our hospital.
Zhi
Keqian
K
Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Number 98, Xiwu Road, Xi'an 710004, ShaanXi, China. zhikeqian@sina.com
Wen
Yuming
Y
Li
Longjiang
L
Ren
Wenhao
W
D000293:Adolescent; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D002648:Child; D005145:Face; D005260:Female; D006801:Humans; D015552:Injections, Intralesional / Q000009:adverse effects; D008297:Male; D009059:Mouth Diseases / Q000628:therapy; D015911:Sclerotherapy / Q000009:adverse effects; D054079:Vascular Malformations / Q000628:therapy*
D001761:Bleomycin; C025703:bleomycetin