A naturalistic multicenter trial of a 12-week weight management program for overweight and obese patients with schizophrenia or schizoaffective disorder.
OBJECTIVE
The primary aim of this study was to examine the efficacy and feasibility of a weight control program for overweight and obese patients with schizophrenia or schizoaffective disorder using a large sample across various clinical settings.


METHODS
Psychiatric patients taking antipsychotics participated in a 12-week weight management program at 33 clinical centers across South Korea, and the data for 232 subjects who had a body mass index (BMI) 25 kg/m(2) or above and were diagnosed with DSM-IV schizophrenia or schizoaffective disorder were used in the final analysis. The primary measures of efficacy were changes in body weight and BMI. The study was conducted from December 2005 to July 2006.


RESULTS
These patients showed significant mean +/- SD reductions in BMI (0.98 +/- 1.01 kg/m(2), p < .001) and body weight (2.64 +/- 2.75 kg, p < .001), with moderate compliance, after the 12-week intervention. Diet compliance was the strongest single predictor of weight loss. Although significant differences in BMI reduction occurred between groups classified by clinical setting and compliance, all sex, age, clinical setting, compliance, and initial BMI groups showed significant BMI reductions, which fell between 0.4 and 1.5 kg/m(2).


CONCLUSIONS
Overall results suggest that a weight management program may be disseminated and adopted by practitioners across settings, resulting in short-term weight loss in schizophrenic and schizoaffective patients.
Lee
Seung Jae
SJ
Department of Psychiatry, Seoul National University Hospital & Neuroscience Institute, Seoul, South Korea.
Choi
Eun Ju
EJ
Kwon
Jun Soo
JS
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015992:Body Mass Index; D004035:Diet Therapy / Q000379:methods*; D004359:Drug Therapy, Combination; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000628:therapy; D050177:Overweight / Q000453:epidemiology* / Q000628:therapy*; D010349:Patient Compliance / Q000706:statistics & numerical data*; D016730:Program Development; D011618:Psychotic Disorders / Q000188:drug therapy / Q000453:epidemiology*; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology*; D015431:Weight Loss / Q000502:physiology*
D014150:Antipsychotic Agents