Synthesis and absolute configuration of hormone alpha1.
An important biological event in phytopathogens of the genus Phytophthora is sexual reproduction, which is conducted by two mating types, A1 and A2. A factor known as hormone alpha1 is secreted by the A1 mating type and induces the formation of sexual spores (oospores) in the A2 mating type. Here we describe the asymmetric synthesis and assignment of the absolute configuration of hormone alpha1 by oospore-inducing assays of the synthesized isomers.
Yajima
Arata
A
Department of Fermentation Science, Faculty of Applied Biological Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-ku, Tokyo 156-8502, Japan. ayaji@nodai.ac.jp
Qin
Yong
Y
Zhou
Xuan
X
Kawanishi
Naoki
N
Xiao
Xue
X
Wang
Jue
J
Zhang
Dan
D
Wu
Yi
Y
Nukada
Tomoo
T
Yabuta
Goro
G
Qi
Jianhua
J
Asano
Tomoyo
T
Sakagami
Youji
Y
D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D005656:Fungal Proteins / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D010316:Particle Size; D010838:Phytophthora / Q000737:chemistry*; D013237:Stereoisomerism
D004224:Diterpenes; D005656:Fungal Proteins; C504077:mating hormone alpha1, Phytophthora