title: Unmeasured anions: the unknown unknowns.
abstract: Evidence is emerging that elevated concentrations of the intermediates of the citric acid cycle may contribute to unmeasured anions in critical illness. Both the anion gap and the strong ion gap are used as scanning tools for recognition of these anions. The mechanisms underlying these elevations and their significance require further clarification.
authors.forename: Bala
authors.initials: B
authors.lastname: Venkatesh
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Morgan
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000378:metabolism*; D000818:Animals; D000838:Anions / Q000378:metabolism*; D006801:Humans; D012771:Shock, Hemorrhagic / Q000378:metabolism*
chemical_list: D000838:Anions