title: Comparison of efficacy of selamectin, ivermectin and mebendazole for the control of gastrointestinal nematodes in rhesus macaques, China.
abstract: An experiment was conducted to evaluate the efficacy of ivermectin and mebendazole compared with selamectin against gastrointestinal nematodes in rhesus macaques. A total of 60 rhesus macaques (Macaca mulatta), which were all infected with gastrointestinal nematodes, were randomly assigned to three treatment groups (selamectin, ivermectin and mebendazole) and one control group. Fecal samples for determining nematode egg counts were collected pre- and post-treatment. All treatments resulted in decrease in the number of eggs per gram (EPG) in the post-treatment sample compared with the pre-treatment sample. Reductions of mean egg counts from day -3 levels were 99.4% for selamectin, 99.2% for ivermectin and 99.4% for mebendazole on trial day 11, respectively. However, no significant difference was found among treatment groups. According to the data demonstrating a similar efficacy in selamectin-, ivermectin- and mebendazole-treated rhesus macaques, it was effective and convenient to apply either selamectin and ivermectin or mebendazole in rotation on the local conditions.
authors.affiliation: Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Guang-You
authors.initials: GY
authors.lastname: Yang
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Yan
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Bian
authors.forename: An-Chun
authors.initials: AC
authors.lastname: Chen
authors.forename: Feng-Jun
authors.initials: FJ
authors.lastname: Bi
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D002681:China; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000662:veterinary*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008253:Macaca mulatta; D008463:Mebendazole / Q000627:therapeutic use*; D008992:Monkey Diseases / Q000188:drug therapy*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; D008463:Mebendazole; C414354:selamectin