title: Tumour-immune cell interactions modulated by chemokines.
abstract: BACKGROUND
  Chemokines are involved in almost all aspects of tumour establishment and progression.
  
  
  OBJECTIVE
  This review gives an insight into the complexity of chemokines and chemokine signalling in tumours, especially focusing on the tuning of the immune system within the tumour microenvironment.
  
  
  METHODS
  Experimental evidence from manipulation of the chemokine network in murine models and in vitro data are critically discussed, and the current status and potential future interventions therapeutically targeting chemokines for efficient and long-lasting tumour control in cancer patients are described.
authors.affiliation: Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria. Karin.Joehrer@tkfi.at
authors.forename: Karin
authors.initials: K
authors.lastname: Jöhrer
authors.forename: Lisa
authors.initials: L
authors.lastname: Pleyer
authors.forename: Angelika
authors.initials: A
authors.lastname: Olivier
authors.forename: Eva
authors.initials: E
authors.lastname: Maizner
authors.forename: Claudia
authors.initials: C
authors.lastname: Zelle-Rieser
authors.forename: Richard
authors.initials: R
authors.lastname: Greil
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D019707:Receptors, Chemokine / Q000378:metabolism / Q000502:physiology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine