title: Transient pancytopenia preceding acute lymphoblastic leukemia with positive Philadelphia chromosome.
abstract: Transient pancytopenia preceding acute lymphoblastic leukemia (pre-ALL) is a rare but well-known occurrence usually affecting children and adolescents. Though pre-ALL in a few adults has ever been reported, the association of this preleukemic syndrome with positive Philadelphia chromosome and P190(BCR-ABL) is extremely rare. To the best of our knowledge, this is the first report of adult B-cell type pre-ALL with positive Philadelphia chromosome and P190(BCR-ABL) published in the literature. We report the case of a 49-year-old woman who was diagnosed with B-cell type ALL associated positive Philadelphia chromosome and P190(BCR-ABL) preceded by transient pancytopenia. The clinical, morphologic, immunophenotypic and molecular features of this patient are described and the literature reviewed.
authors.affiliation: Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors.forename: Qiubai
authors.initials: Q
authors.lastname: Li
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: You
authors.forename: Ping
authors.initials: P
authors.lastname: Zou
mesh_terms: D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D008875:Middle Aged; D010198:Pancytopenia / Q000175:diagnosis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D011289:Preleukemia / Q000175:diagnosis
chemical_list: D016044:Fusion Proteins, bcr-abl