title: Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.
abstract: Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.
authors.affiliation: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Marcel E
authors.initials: ME
authors.lastname: Curlin
authors.forename: Kurt
authors.initials: K
authors.lastname: Diem
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Ananta K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhu
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Woodward
authors.forename: Janine
authors.initials: J
authors.lastname: Maenza
authors.forename: Claire E
authors.initials: CE
authors.lastname: Stevens
authors.forename: Joanne
authors.initials: J
authors.lastname: Stekler
authors.forename: Ann C
authors.initials: AC
authors.lastname: Collier
authors.forename: Indira
authors.initials: I
authors.lastname: Genowati
authors.forename: Wenjie
authors.initials: W
authors.lastname: Deng
authors.forename: Rafael
authors.initials: R
authors.lastname: Zioni
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Tuofu
authors.initials: T
authors.lastname: Zhu
authors.forename: James I
authors.initials: JI
authors.lastname: Mullins
mesh_terms: D018562:Disease Transmission, Infectious; D005260:Female; D015686:Gene Products, env / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006031:Glycosylation; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019302:HIV Envelope Protein gp160 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160