title: Evolution of VX2 carcinoma in rabbit tibia: magnetic resonance imaging with pathologic correlation.
abstract: OBJECTIVE
  To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation.
  
  
  METHODS
  VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done.
  
  
  RESULTS
  On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (1 week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks).
  
  
  CONCLUSIONS
  The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor.
authors.affiliation: Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jung-Ah
authors.initials: JA
authors.lastname: Choi
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Kang
authors.forename: Han Kyeom
authors.initials: HK
authors.lastname: Kim
authors.forename: In Chan
authors.initials: IC
authors.lastname: Song
authors.forename: Young I I
authors.initials: YI
authors.lastname: Kim
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Kang
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D011817:Rabbits; D013977:Tibia / Q000473:pathology*