title: Successful management of life-threatening choriocarcinoma syndrome with rupture of pulmonary metastatic foci causing hemorrhagic shock.
abstract: We report a case of a man with testicular cancer metastatic to the lung and retroperitoneal lymph node, with significant elevation of serum levels of human chorionic gonadotropin, 534,000 mIU/mL. Just after the initiation of chemotherapy, life-threatening hemothorax occurred and hemorrhagic shock ensued. The pulmonary tumor had broken off, and lower lobectomy was carried out. Pathologic examination of the specimen revealed choriocarcinoma and yolk sac tumor. Through multimodal treatments he achieved complete remission. To our knowledge, this is the first case report of choriocarcinoma syndrome with life-threatening hemorrhage caused by rupture of pulmonary metastases, resulting in complete remission through multimodal treatments.
authors.affiliation: Department of Urology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Tatokoro
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawakami
authors.forename: Mizuaki
authors.initials: M
authors.lastname: Sakura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kihara
authors.forename: Hideki
authors.initials: H
authors.lastname: Akamatsu
mesh_terms: D000328:Adult; D002822:Choriocarcinoma / Q000150:complications* / Q000556:secondary*; D004638:Emergency Treatment; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000556:secondary*; D008297:Male; D012074:Remission Induction; D012422:Rupture, Spontaneous; D012771:Shock, Hemorrhagic / Q000209:etiology*; D013736:Testicular Neoplasms / Q000473:pathology*