title: Partial bladder transplantation with en bloc kidney transplant--the first case report of a 'bladder patch technique' in a human.
abstract: Transplantation of the urinary bladder has not been reported in humans. We transplanted a portion of the donor bladder with an en bloc kidney graft in a 12-month-old girl. The child had a congenital hypoplastic single kidney with an ectopic ureteral opening into the vagina. Her native bladder was extremely small. Bilateral kidneys were transplanted en bloc with their ureters connected to a patch of the donor bladder, which encompassed the bilateral ureterovesical junctions (UVJs) (bladder patch technique). Approximately one-third of the donor bladder wall was used. The bladder patch reperfused well via blood supply from the ureters. Posttransplant cystoscopy with retrograde cystogram revealed a viable transplanted bladder with normal emptying of transplanted ureters. No reflux across the donor UVJs was seen in a voiding cystourethrogram. The child is doing well with normal renal function at 18-month follow-up.
authors.affiliation: Division of Transplant, University of Miami, Miami, FL, USA. tkato@med.miami.edu
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: G
authors.initials: G
authors.lastname: Selvaggi
authors.forename: G
authors.initials: G
authors.lastname: Burke
authors.forename: G
authors.initials: G
authors.lastname: Ciancio
authors.forename: G
authors.initials: G
authors.lastname: Zilleruelo
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: R
authors.initials: R
authors.lastname: Gosalbez
authors.forename: A
authors.initials: A
authors.lastname: Tzakis
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016030:Kidney Transplantation / Q000276:immunology / Q000379:methods*; D016896:Treatment Outcome; D014513:Ureter / Q000002:abnormalities; D001743:Urinary Bladder / Q000002:abnormalities / Q000601:surgery* / Q000637:transplantation*
chemical_list: D007166:Immunosuppressive Agents