title: N-myristoyltransferase: a novel target.
abstract: Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid, myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for anticancer, antiviral and antifungal agents. Recent N-myristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.
authors.affiliation: Department of Pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Sector-8, C.B.D., Belapur, Navi Mumbai-400614, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Prasad
authors.forename: M P
authors.initials: MP
authors.lastname: Toraskar
authors.forename: V J
authors.initials: VJ
authors.lastname: Kadam
mesh_terms: D000217:Acyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D000977:Antiparasitic Agents / Q000378:metabolism / Q000494:pharmacology; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D000998:Antiviral Agents; D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase