Hepatic lobectomy and segmentectomy models using microsurgical techniques.
The mouse and rat models are the most commonly utilized experimental models of partial liver resection. Microscope-assisted partial hepatectomy is associated with better outcomes by reducing the risk of vena cava stenosis after ligature and injury to other liver pedicles. In addition, microsurgery allows lobectomies and segmentectomies after individual ligation of intrahepatic vascular branches, including the left and right segments of the median lobe, which has not been reported before. Here, we describe a new technique (catheter-assisted suture technique) and report our experience with partial hepatectomies in rodents using a microsurgical approach.
Martins
Paulo Ney Aguiar
PN
Department of Surgery, Transplant Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. paulo.martins@tbrc.mgh.harvard.edu
Neuhaus
Peter
P
D000818:Animals; D002408:Catheters, Indwelling; D004210:Dissection / Q000379:methods; D006498:Hepatectomy / Q000379:methods*; D008026:Ligation / Q000379:methods; D051379:Mice; D008866:Microsurgery / Q000379:methods*; D023421:Models, Animal; D051381:Rats; D013536:Suture Techniques / Q000295:instrumentation*