[Association between the TPH2 gene and suicidal behavior].
The paper describes the location of TPH gene and the role of serotonin for a human organism. It analyses the path of serotonin formation from tryptophan as a result of hydroxylation and decarboxylation. It underscores the part the TPH gene plays in disclosing depressive disorders and suicidal tendencies. The opinions of different researchers on the relation between the individual TPH alleles and the occurrences of suicidal tendencies have been presented, indicating the obstacles in determining clear results of the research. The paper pays attention to the fact that variants of TPH may influence human behaviour. The author has also pointed to the role of hydroxyindole acetic acid in cerebrospinal fluid, which may be significant in suicidal tendencies. Pathogenesis of periodical depressive mood disorders has also been emphasized. A location of serotonin transporter gene and a role of its polymorphism in arising depressive disorders have been presented. Genetically conditioned differences in effectiveness of the therapy in patients with recognised diagnosis of depressive syndrome indicate strong relations with pharmacokinetic and pharmacodynamic mechanism of antidepressant activities.
Kamrowska
Anna
A
Uniwersytet Medyczny w Łodzi, Klinika Psychiatrii Doroslych. ann.kamrowska@poczta.onet.pl
D000483:Alleles; D001519:Behavior / Q000502:physiology*; D003866:Depressive Disorder / Q000235:genetics*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D011110:Polymorphism, Genetic; D013406:Suicide, Attempted / Q000523:psychology*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D006897:Hydroxyindoleacetic Acid; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase