title: Decreased placental X-linked inhibitor of apoptosis protein in an ovine model of intrauterine growth restriction.
abstract: OBJECTIVE
  The objective of the study was to assess placental apoptosis at both midgestation and near term in an ovine model of placental insufficiency (PI) and intrauterine growth restriction (IUGR).
  
  
  METHODS
  At 40 days' gestational age (dGA), 2 groups of 4 ewes were exposed to hyperthermic conditions for either 55 days or 80 days to induce IUGR with necropsies at 95 (midgestation) and 130 dGA (term = 140 dGA), respectively. Blood gases were assessed and placental tissues obtained for apoptosis analyses.
  
  
  RESULTS
  PI-IUGR pregnancies showed: (1) a decrease in fetal O(2) saturation and pO(2) (P < .04), (2) an increase in placental villi apoptosis (P < .05) at midgestation and near term, and (3) a decrease of cotyledon X-linked inhibitor of apoptosis protein (XIAP) at both gestational periods (P < .04) with no differences in caruncle XIAP protein.
  
  
  CONCLUSIONS
  Placental villous apoptosis is increased at midgestation and near term in our ovine model of IUGR, and this increase is associated with a significant decrease in XIAP protein in the cotyledon of IUGR animals.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Perinatal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA. juan.arroyo@uchsc.edu
authors.forename: Juan A
authors.initials: JA
authors.lastname: Arroyo
authors.forename: Russell V
authors.initials: RV
authors.lastname: Anthony
authors.forename: Henry L
authors.initials: HL
authors.lastname: Galan
mesh_terms: D000818:Animals; D017209:Apoptosis; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D005334:Fever / Q000150:complications; D005865:Gestational Age; D010920:Placenta / Q000378:metabolism* / Q000473:pathology*; D011247:Pregnancy; D012756:Sheep; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000378:metabolism*
chemical_list: D051636:X-Linked Inhibitor of Apoptosis Protein