Target-induced strand release (TISR) from aptamer-DNA duplex: a general strategy for electronic detection of biomolecules ranging from a small molecule to a large protein.
We describe a general strategy for electronic aptamer-based biosensor that is based on target-induced strand release (TISR) of a redox-modified aptamer from the aptamer-capture DNA duplex bound on an electrode.
Yoshizumi
Jyun
J
Department of Materials Science and Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, 671-2201, Japan.
Kumamoto
Satoshi
S
Nakamura
Mitsunobu
M
Yamana
Kazushige
K
D000818:Animals; D052157:Aptamers, Nucleotide; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004247:DNA; D008832:Microchemistry / Q000379:methods; D036103:Nanotechnology; D010084:Oxidation-Reduction; D011506:Proteins / Q000032:analysis*
D052157:Aptamers, Nucleotide; D011506:Proteins; D004247:DNA