Unnarmicins A and C, new antibacterial depsipeptides produced by marine bacterium Photobacterium sp. MBIC06485.
Two new antibiotic depsipeptides, unnarmicins C (1) and A (2), were isolated from the fermentation broth of a marine bacterium, Photobacterium sp. strain MBIC06485. The structure of 1 was established by spectroscopic studies and chiral analyses of its chemical degradation/conversion products, and that of 2 by comparing its NMR, MS, and CD data with those of 1. Both compounds selectively inhibited the growth of two strains belonging to the genus Pseudovibrio, one of the most prevalent genera in the marine environments within the class Alphaproteobacteria.
Oku
Naoya
N
Marine Biotechnology Institute Co. Ltd., 3-75-1 Heita, Kamaishi, Iwate, Japan.
Kawabata
Kazutaka
K
Adachi
Kyoko
K
Katsuta
Atsuko
A
Shizuri
Yoshikazu
Y
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology; D047630:Depsipeptides / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010776:Photobacterium / Q000145:classification / Q000378:metabolism*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C529278:unnarmicin A; C529279:unnarmicin C