Autoimmunity and celiac disease.
In celiac disease (CD), abnormal immune-mediated responses follow ingestion of gluten. Although the triggering agent is a dietary protein, the disease has autoimmune components because of the presence of autoantibodies and its association with autoimmune conditions. We review the most recent studies on CD pathogenesis and the possibilities to modulate immune dysfunction in CD.
Gianfrani
Carmen
C
Institute of Food Sciences of CNR, Avellino, Italy.
Troncone
Riccardo
R
La Cava
Antonio
A
D000595:Amino Acid Sequence; D015551:Autoimmunity / Q000276:immunology*; D002446:Celiac Disease / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D004847:Epithelial Cells / Q000276:immunology / Q000473:pathology; D019204:GTP-Binding Proteins; D005983:Glutens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008969:Molecular Sequence Data; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology
D005983:Glutens; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins