Alpha-fetoprotein (AFP)-producing adrenocortical carcinoma--long survival with various therapeutic strategies including a lung resection: report of a case.
We experienced a very rare case of late pulmonary metastasis from ACC. The patient was a 40-year-old woman who had undergone a left adrenectomy 12 years earlier. Instead of a large metastatic lung tumor with hemothorax and the existence of metastases in other organs, combined therapy of repeated resections for metastases and adjuvant therapy allowed for almost a 36-month survival following the first recurrence and a good quality of life. In addition, a blood and pathological study revealed that the tumor in this case was an alpha-fetoprotein-producing ACC, which is, as far as we could ascertain, the first case of its kind.
Hamanaka
Wakako
W
Department of Thoracic Surgery, Imakiire General Hospital, 4-16 Shimotatsuo-cho, Kagoshima 892-0852, Japan.
Yoneda
Satoshi
S
Shirakusa
Takayuki
T
Shirahama
Hiroshi
H
Tashiro
Yukie
Y
Iwasaki
Akinori
A
Shiraishi
Takeshi
T
Tsuru
Hirohumi
H
D000306:Adrenal Cortex Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D011013:Pneumonectomy; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins