Alkaloids from Daphniphyllum oldhami.
Four new Daphniphyllum alkaloids, daphnioldhanines H-K ( 1- 4), along with 34 known alkaloids, were isolated from Daphniphyllum oldhami. The known alkaloid dehydrodaphnigraciline ( 5) is now reported as a natural product. Their structures were elucidated by spectroscopic methods, especially 2D NMR techniques. The effects against platelet aggregation of compounds 1, 3, and 5 were evaluated, and 3 showed stronger activity against platelet aggregation induced by PAF. This is the first report of quinolizidine alkaloids from the genus Daphniphyllum.
Mu
Shu-Zhen
SZ
The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Guiyang 550002, People's Republic of China.
Wang
Jun-Song
JS
Yang
Xiao-Sheng
XS
He
Hong-Ping
HP
Li
Chun-Shun
CS
Di
Ying-Tong
YT
Wang
Ye
Y
Zhang
Yu
Y
Fang
Xin
X
Huang
Lie-Jun
LJ
Hao
Xiao-Jiang
XJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054837:Quinolizidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031995:Saxifragaceae / Q000737:chemistry*
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D054837:Quinolizidines