Adipokines and insulin resistance during pregnancy.
Normal pregnancy has been characterized as a "diabetogenic state". On the other hand, the adipose tissue is now considered an active organ, capable of secreting substances such as adipokines, which may play a role in the pathogenesis of insulin resistance. Resistin, leptin serum and placental levels increase as pregnancy progresses, which is in contrast to levels of adiponectin. These levels correlate with the state of reduced insulin sensitivity often developed in the latter stages of pregnancy. The objective of this article is to review recent advances in our understanding of adipokines and insulin resistance during pregnancy.
Zavalza-Gómez
Ana Bertha
AB
Division of Research, Hospital of Obstetrics and Gynecology at Western Medical Center, Mexican Institute of Social Security, Jalisco, Mexico. postmen71@yahoo.com.mx
Anaya-Prado
Roberto
R
Rincón-Sánchez
Ana Rosa
AR
Mora-Martínez
José Miguel
JM
D054392:Adipokines / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D054392:Adipokines; D007328:Insulin