[Expressions of matrix metalloproteinase-9 and interleukin-8 in nasopharyngeal carcinoma and association with Epstein-Barr virus latent membrane protein-1].
OBJECTIVE
To investigate the expressions of matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8) in nasopharyngeal carcinoma and their association with Epstein-Barr virus latent membrane protein-1 (LMP-1).


METHODS
The expressions of MMP-9, IL-8 and LMP-1 were immunohistochemical studied in 53 nasopharyngeal carcinoma sections. We statistically analyzed the correlation of these data and also the relationship between the clinical features and the experimental data of these patients.


RESULTS
The positive expression rate of MMP-9, IL-8 and LMP-1 were all 66.04% (35/53) and their average expression score were (33.19 +/- 29.73)%, (33.46 +/- 30.23)%, (35.49 +/- 29.63)% respectively. The expressions of MMP-9 and IL-8 both showed positive correlation with the expression of LMP-1 (r = 0.792, 0.786 respectively). The expressions of MMP-9, IL-8 and LMP-1 showed significant relationship with lymph nodes metastasis (P < 0.05), but no-significant association with age, gender, pathological classification, and clinical stage.


CONCLUSIONS
The expressions of MMP-9, IL-8 and LMP-1 were significantly associated with neck lymph nodes metastasis in nasopharyngeal carcinoma. The correlation between LMP-1 and MMP-9, IL-8 showed LMP-1 might enhance neck lymph nodes metastasis by up-regulating the expressions of MMP-9 and IL-8.
Cai
Zhaoyang
Z
Department of Otolaryngology, First Hospital of Wenling City, Wenling, 317500, China.
Tang
Jianguo
J
Li
Xuan
X
Chen
Xiaoyou
X
Ying
Zhengbiao
Z
Zhu
Yangli
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009333:Neck; D011379:Prognosis; D014763:Viral Matrix Proteins / Q000378:metabolism*; D055815:Young Adult
C508606:CXCL8 protein, human; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D016209:Interleukin-8; D014763:Viral Matrix Proteins; D020780:Matrix Metalloproteinase 9