title: Comparison of the incidence of opacification of Hydroview hydrogel intraocular lenses with the ophthalmic viscosurgical device used during surgery.
abstract: OBJECTIVE
  To determine the effect of intraoperative ophthalmic viscosurgical devices (OVDs) on late opacification of the Hydroview hydrogel intraocular lens (IOL) (Bausch & Lomb Surgical).
  
  
  METHODS
  Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  
  
  METHODS
  A retrospective study of 949 cases of Hydroview IOL implantations from February 1998 to September 2000 was conducted. Of the 949 implantations, 462 were performed by 1 surgeon (J.H.S.) using Viscoat (sodium chondroitin sulfate 4.0%-sodium hyaluronate 3.0%) and 487 were performed by a second surgeon (W.A.N.) using Biolon (sodium hyaluronate 1.0%). Surgical techniques were identical with the exception of surgeon OVD preference. The number of IOLs opacifying and requiring explantation was determined in each group.
  
  
  RESULTS
  Seventy-one Hydroview IOLs had surface calcification deposits that presented a mean of 39 months postoperatively. Twenty-two IOLs opacified sufficiently to warrant a recommendation of IOL explantation; 20 IOLs were explanted, and 2 surgeries were cancelled due to death or disability. In all cases of opacification, Viscoat had been used intraoperatively. This represented a 15.4% incidence of opacification in the Viscoat group, with 31.0% cases severe enough to warrant a recommendation of explantation.
  
  
  CONCLUSIONS
  The results suggest that the intraoperative use of Viscoat has a facilitating role in the development of late calcification and opacification of the Hydroview IOL.
authors.affiliation: Department of Eye Medicine and Surgery, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Sher
authors.forename: Patrick
authors.initials: P
authors.lastname: Gooi
authors.forename: William
authors.initials: W
authors.lastname: Dubinski
authors.forename: Seymour
authors.initials: S
authors.lastname: Brownstein
authors.forename: Sherif
authors.initials: S
authors.lastname: El-Defrawy
authors.forename: Wesley A
authors.initials: WA
authors.lastname: Nash
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000209:etiology; D002807:Chondroitin / Q000009:adverse effects*; D002809:Chondroitin Sulfates; D020878:Device Removal; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D015994:Incidence; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D004338:Drug Combinations; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates