Differences in insulin sensitivity and secretory capacity based on OGTT in subjects with impaired glucose regulation.
BACKGROUND
This study examined whether defects in insulin secretion contribute to the development and progression of type 2 diabetes mellitus (T2DM).


METHODS
Plasma insulin and glucose were measured after a glucose tolerance test to calculate the insulinogenic index (IGI) and the HOMA-IR Homeostasis model assessment of insulin resistance in subjects with normal glucose tolerance (NGT), prediabetes (preDM, n = 49), and T2DM patients with disease duration < 1 year (n = 84), 1 approximately 5 years (n = 45), or > 5 years (n = 37). Plasma proinsulin and adiponectin levels were also measured as a parameter of insulin secretion and resistance.


RESULTS
The mean HOMA-IR increased and the adiponectin levels decreased relative to the deterioration of glucose tolerance in NGT and preDM subjects. However, differences in the HOMA-IR were not related to disease duration in T2DM subjects. The mean IGI was similar in NGT and preDM subjects, but there were significant deteriorations in IGI relative to the duration of diabetes.


CONCLUSIONS
Defects in both insulin sensitivity and insulin secretion contribute to T2DM, but decreased insulin secretion may be more important in the development and progression of T2DM.
Rhee
Sang Youl
SY
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
Kwon
Mi Kwang
MK
Park
Byong-Jo
BJ
Chon
Suk
S
Jeong
In-Kyung
IK
Oh
Seungjoon
S
Ahn
Kyu Jeung
KJ
Chung
Ho Yeon
HY
Kim
Sung Woon
SW
Kim
Jin-Woo
JW
Kim
Young Seol
YS
Woo
Jeong-Taek
JT
D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004196:Disease Outbreaks; D005260:Female; D005951:Glucose Tolerance Test; D006305:Health Status Indicators; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged
D007328:Insulin