A high-throughput approach towards a novel formulation of fenofibrate in omega-3 oil.
A novel lipid formulation containing fenofibrate in omega-3 oil was developed using a novel high-throughput screening platform. The optimized formulation combines the cardiovascular health benefits from omega-3 oil with the potent lipid-regulating effect of fenofibrate. When tested against the current marketed product Tricor in healthy human volunteers, the new formulation was shown to be equivalent to Tricor.
Ratanabanangkoon
Pasut
P
TransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, MA 02421, United States.
Guzman
Hector
H
Almarsson
Orn
O
Berkovitz
Dina
D
Tokarcyzk
Stephanie
S
Straughn
Arthur B
AB
Chen
Hongming
H
D000284:Administration, Oral; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D018592:Cross-Over Studies; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D011345:Fenofibrate / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D015394:Molecular Structure; D012995:Solubility
D004655:Emulsions; D005079:Excipients; D015525:Fatty Acids, Omega-3; D000960:Hypolipidemic Agents; D011345:Fenofibrate