title: Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia.
abstract: We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derived from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, with proliferation of CD4(-) CD8+. The co-existence of two translocations involving both sex chromosomes in a case of T-PLL is rare. Chromosomal instability associated with the disease progression may have allowed the emergence of cell clones with translocations involving the sex chromosomes and the ring chromosome observed.
authors.affiliation: Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. morato.oliveira@yahoo.com.br
authors.forename: F M
authors.initials: FM
authors.lastname: de Oliveira
authors.forename: L G
authors.initials: LG
authors.lastname: Tone
authors.forename: B P
authors.initials: BP
authors.lastname: Simões
authors.forename: E M
authors.initials: EM
authors.lastname: Rego
authors.forename: A F
authors.initials: AF
authors.lastname: Marinato
authors.forename: R H
authors.initials: RH
authors.lastname: Jácomo
authors.forename: R P
authors.initials: RP
authors.lastname: Falcão
mesh_terms: D000328:Adult; D043171:Chromosomal Instability / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D006801:Humans; D015461:Leukemia, Prolymphocytic, T-Cell / Q000235:genetics*; D008297:Male; D012303:Ring Chromosomes; D032681:Spectral Karyotyping; D014178:Translocation, Genetic