Sex differences in muscle-derived stem cells and skeletal muscle.
Sex is well known to influence life expectancy and disposition to disease. Stem and progenitor cells are believed to persist throughout life, and they contribute to the repair and healthy maintenance of tissue; consequently, sex-related differences demonstrated by stem cells may provide insight to sex-related differences in aging, disease, and healing. However, cell sex is an often overlooked variable in stem cell biology.
Deasy
Bridget M
BM
Department of Orthopaedic Surgery, School of Medicine, Rangos Research Center, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15260, USA. deasybm@upmc.edu
Schugar
Rebecca C
RC
Huard
Johnny
J
D053687:Adult Stem Cells / Q000502:physiology*; D000375:Aging / Q000502:physiology; D000818:Animals; D018929:Cell Culture Techniques; D004194:Disease / Q000209:etiology; D004967:Estrogens / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D008297:Male; D008954:Models, Biological; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D009929:Organ Size; D018384:Oxidative Stress / Q000502:physiology; D020286:Pericytes / Q000502:physiology; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology; D012727:Sex Characteristics
D004967:Estrogens