PPARalpha is involved in photoentrainment of the circadian clock.
We found that bezafibrate, a ligand of peroxisome proliferator-activated receptor alpha (PPARalpha), advances the active phase of mice under light-dark (LD) conditions in a photoperiod-dependent manner. Bezafibrate gradually advanced the activity onset that consequently almost completely reversed the active phase from the dark to the light period under a long photoperiod (18 h of light and 6 h of darkness: LD 18 : 6). The activity onset was not changed under a short photoperiod (LD 8 : 16) or under constant illumination. These observations suggest that PPARalpha is involved in entrainment of the circadian clock to environmental LD conditions.
Oishi
Katsutaka
K
Clock Cell Biology Research Group, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.
Shirai
Hidenori
H
Ishida
Norio
N
D000221:Adaptation, Ocular / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology* / Q000528:radiation effects; D003623:Dark Adaptation / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D004779:Environment Design; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008027:Light; D051379:Mice; D008813:Mice, Inbred ICR; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism*; D010775:Photic Stimulation; D017440:Photoperiod
D000960:Hypolipidemic Agents; D047493:PPAR alpha; D001629:Bezafibrate