Bioevaluation of 32P patch designed for the treatment of skin diseases.
OBJECTIVE
The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases.


METHODS
The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied.


RESULTS
Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples.


CONCLUSIONS
The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.
Salgueiro
Maria Jimena
MJ
Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina. jsalgueiro@ffyb.uba.ar
Duran
Hebe
H
Palmieri
Monica
M
Pirchio
Rosana
R
Medina
Vanina
V
Ughetti
Ricardo
R
Croci
Maximo
M
Nicolini
Jorge
J
Zubillaga
Marcela
M
D000279:Administration, Cutaneous; D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D004195:Disease Models, Animal; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008657:Metabolic Clearance Rate; D051379:Mice; D010761:Phosphorus Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000532:radiotherapy*; D014018:Tissue Distribution; D016896:Treatment Outcome
D010761:Phosphorus Radioisotopes