title: CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability.
abstract: CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.
authors.affiliation: Department of Molecular Pharmacology and Biological Chemistry, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Ray
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kiyokawa
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018450:Disease Progression; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D042822:Genomic Instability; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D020687:cdc25 Phosphatases / Q000737:chemistry / Q000502:physiology*; D018631:ras Proteins / Q000378:metabolism
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D020687:cdc25 Phosphatases; D018631:ras Proteins