Acremolides A-D, lipodepsipeptides from an Australian marine-derived fungus, Acremonium sp.
An Australian estuarine isolate of an Acremonium sp. (MST-MF588a) yielded the two known compounds 19- O-acetylchaetoglobosin D ( 1) and 19- O-acetylchaetoglobosin B ( 2), as the sole cytotoxic principles, along with the known aromatic metabolite RKB 3564S ( 3), and a novel family of lipodepsipeptides, acremolides A-D ( 4- 7). Structures were assigned to 4- 7 on the basis of detailed spectroscopic analysis and chemical derivatization and by application of a new C 3 Marfey's method for amino acid analysis.
Ratnayake
Ranjala
R
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Fremlin
Leith J
LJ
Lacey
Ernest
E
Gill
Jennifer H
JH
Capon
Robert J
RJ
D000164:Acremonium / Q000737:chemistry*; D000818:Animals; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013648:Tasmania
C529253:19-O-acetylchaetoglobosin B; C529252:19-O-acetylchaetoglobosin D; D047630:Depsipeptides