title: Bioelectrical impedance analysis and diabetes mellitus: which correlation among fructosamine, glycosylated haemoglobin and exchangeable potassium.
abstract: OBJECTIVE
  Bioelectrical impedance analysis (BIA) can monitor diabetics suffering from the frequently occurring state of hyperglycemia, as this can cause alterations in the water distribution in the body. The aim of the present study was to evaluate the relationship between the composition of the body and the diabetic disease during decompensation through the impedanciometric analysis in diabetic patients of type 1 and type 2 and to understand the possible alterations of water distribution.
  
  
  METHODS
  The study was carried out with 52 subjects (8 males, 44 females), average years 46.5; 15 of them were diabetic, 7 characterised by diabetes of type 1 and 8 by diabetes of type 2. All the patients recruited were in poor metabolic control (glycosylated hemoglobin [HbAlc] >6%). In order to avoid any errors during the evaluation ofa water distribution in the body, patients suffering from hypertension were excluded from the recruitment process. All patients underwent impedanciometry total body using the HUMAN IM SCAN apparatus multifrequency.
  
  
  RESULTS
  Through the application of BIA, our work has shown how diabetic patients have a lower quantity of extracellular water (ECW) and exchangeable potassium (Ke) in the body, as compared to non-diabetic patients. The causes of this could be the alteration of the plasmic osmolarity and the possible reduction of the mass of metabolically active cells. Further-more a relationship between fructosamine in the blood and Ke has been found and, alongside another, more significant, between HbA1c and Ke. According to the opinions of the authors, such results are worthy for further studies in order to obtain a greater accuracy in the evaluation of the amount of Ke and an alternative in estimation of metabolic control.
authors.affiliation: Department of Biomedical Sciences, University of Catania, Garibaldi Hospital, Catania, Italy. mdimauro@unict.it
authors.forename: M
authors.initials: M
authors.lastname: Di Mauro
authors.forename: D
authors.initials: D
authors.lastname: Lazzarini
authors.forename: P
authors.initials: P
authors.lastname: Fumelli
authors.forename: F
authors.initials: F
authors.lastname: Carle
authors.forename: A
authors.initials: A
authors.lastname: Kosmidis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D001834:Body Water / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D017097:Electric Impedance; D005260:Female; D019270:Fructosamine / Q000032:analysis / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000032:analysis / Q000097:blood*
chemical_list: D019270:Fructosamine; D006442:Glycated Hemoglobin; D011188:Potassium