title: Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.
abstract: BACKGROUND
  Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the susceptibility to lung cancer patients younger than 51 years at diagnosis.
  
  
  METHODS
  246 patients with a primary, histologically or cytologically confirmed neoplasm, recruited from 2000 to 2003 in major lung clinics across Germany, were matched to 223 unrelated healthy controls. 11 single nucleotide polymorphisms of genes with reported associations to lung cancer have been genotyped.
  
  
  RESULTS
  Genetic associations or gene-smoking interactions was found for GPX1(Pro200Leu) and EPHX1(His113Tyr). Carriers of the Leu-allele of GPX1(Pro200Leu) showed a significant risk reduction of OR = 0.6 (95% CI: 0.4-0.8, p = 0.002) in general and of OR = 0.3 (95% CI:0.1-0.8, p = 0.012) within heavy smokers. We could also find a risk decreasing genetic effect for His-carriers of EPHX1(His113Tyr) for moderate smokers (OR = 0.2, 95% CI:0.1-0.7, p = 0.012). Considered both variants together, a monotone decrease of the OR was found for smokers (OR of 0.20; 95% CI: 0.07-0.60) for each protective allele.
  
  
  CONCLUSIONS
  Smoking is the most important risk factor for young lung cancer patients. However, this study provides some support for the T-Allel of GPX1(Pro200Leu) and the C-Allele of EPHX1(His113Tyr) to play a protective role in early onset lung cancer susceptibility.
authors.affiliation: Department of Genetic Epidemiology, Georg-August University of Göttingen, Medical School, Germany. arosenb@gwdg.de
authors.forename: Albert
authors.initials: A
authors.lastname: Rosenberger
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Katrin
authors.initials: K
authors.lastname: Korb
authors.forename: Norman
authors.initials: N
authors.lastname: Klopp
authors.forename: Vera
authors.initials: V
authors.lastname: Zietemann
authors.forename: Gabi
authors.initials: G
authors.lastname: Wölke
authors.forename: Eckart
authors.initials: E
authors.lastname: Meese
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sybrecht
authors.forename: Florian
authors.initials: F
authors.lastname: Kronenberg
authors.forename: Matthias
authors.initials: M
authors.lastname: Cebulla
authors.forename: Maria
authors.initials: M
authors.lastname: Degen
authors.forename: Peter
authors.initials: P
authors.lastname: Drings
authors.forename: Andreas
authors.initials: A
authors.lastname: Gröschel
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Konietzko
authors.forename: Karsten Grosse
authors.initials: KG
authors.lastname: Kreymborg
authors.forename: Karl
authors.initials: K
authors.lastname: Häussinger
authors.forename: Gerd
authors.initials: G
authors.lastname: Höffken
authors.forename: Bettina
authors.initials: B
authors.lastname: Jilge
authors.forename: You-Dschun
authors.initials: YD
authors.lastname: Ko
authors.forename: Harald
authors.initials: H
authors.lastname: Morr
authors.forename: Christine
authors.initials: C
authors.lastname: Schmidt
authors.forename: E-Wilhelm
authors.initials: EW
authors.lastname: Schmidt
authors.forename: Dagmar
authors.initials: D
authors.lastname: Täuscher
authors.forename: Heike
authors.initials: H
authors.lastname: Bickeböller
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000483:Alleles; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004851:Epoxide Hydrolases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005858:Germany; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking; D000094765:Glutathione Peroxidase GPX1
chemical_list: D005819:Genetic Markers; D005979:Glutathione Peroxidase; D004851:Epoxide Hydrolases; C522330:EPHX1 protein, human; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human