[Subchronic toxic effects of fish muscle-bound MCLR].
Subchronic oral gavage toxicity of MCLR in water and in fish muscle was examined in male Balb/C mice for 13 weeks to assess the safety of aquatic products. The results showed that the liver coefficient (p < 0.05), the activities of ALT and AST (p < 0.01) increased significantly and distinct centrilobular to midzonal hepatucellular occurred after oral gavage of dissolved MCLR at a dose of 68.75 microg/kg (body weight), but neither influence on the activities of BUN and Cr nor histological changes on kidney were observed at any time point. In contrast, the administration of fish muscle-bound MCLR at the same dose resulted in no obvious subchronic toxicity in mice, except that the increase of liver coefficient (p < 0.05) and the activity of ALT (p < 0.01) can be observed only at the first week. It was concluded that the toxicity of fish muscle-bound MCLR was much lower than that of dissolved MCLR.
Yang
Fan
F
College of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan 430070, China. sail_neptune@hotmail.com
Xiao
Bang-ding
BD
Chen
Xiao-guo
XG
Wu
Xing-qiang
XQ
Liu
Min
M
D000284:Administration, Oral; D000818:Animals; D002857:Chromium / Q000032:analysis; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis* / Q000517:prevention & control; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008387:Marine Toxins; D051379:Mice; D008807:Mice, Inbred BALB C; D052998:Microcystins / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D017747:Seafood / Q000032:analysis; D018675:Toxicity Tests / Q000379:methods*; D014873:Water Pollutants / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity
D008387:Marine Toxins; D052998:Microcystins; D014873:Water Pollutants; D002857:Chromium; C057862:cyanoginosin LR