Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems.
Alginate based microparticle drug delivery systems were prepared for the sustained release of antineoplastic drugs. Two drugs, 5-fluorouracil (5-FU) and tegafur, were encapsulated into the microparticles. The drug loaded microparticles were fabricated using a very convenient method under very mild conditions, i.e., directly shredding the drug loaded beads into microparticles in a commercial food processor. The mean sizes of the obtained microparticles were between 100 and 200 microm. To effectively sustain the drug release, alginate microparticles were reinforced by chitosan during gelation. The drug release from the chitosan-reinforced alginate microparticles was obviously slower than that from the unreinforced microparticles. The effect of the reinforcement conditions on the drug release property of the microparticles was studied, and the optimized concentration of chitosan solution for reinforcement was identified. The effects of drug feeding concentration and pH value of the release medium on the drug release were investigated.
Yu
Cui-Yun
CY
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
Zhang
Xi-Chen
XC
Zhou
Fang-Zhou
FZ
Zhang
Xian-Zheng
XZ
Cheng
Si-Xue
SX
Zhuo
Ren-Xi
RX
D000464:Alginates / Q000737:chemistry*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D010316:Particle Size; D011134:Polysaccharides / Q000737:chemistry; D005641:Tegafur / Q000008:administration & dosage / Q000737:chemistry
D000464:Alginates; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D011134:Polysaccharides; D005641:Tegafur; D048271:Chitosan; D005472:Fluorouracil