Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines.
Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.
Kok
Stanton Hon Lung
SH
Lo Ka Chung Centre for Natural Anti-cancer Drug Development (Laboratory B), Hong Kong Polytechnic University, Yuk Choi Road, Hung Hom, Kowloon, Hong Kong, China.
Gambari
Roberto
R
Chui
Chung Hin
CH
Yuen
Marcus Chun Wah
MC
Lin
Eva
E
Wong
Raymond Siu Ming
RS
Lau
Fung Yi
FY
Cheng
Gregory Yin Ming
GY
Lam
Wing Sze
WS
Chan
Sau Hing
SH
Lam
Kim Hung
KH
Cheng
Chor Hing
CH
Lai
Paul Bo Shan
PB
Yu
Michael Wing Yiu
MW
Cheung
Filly
F
Tang
Johnny Cheuk On
JC
Chan
Albert Sun Chi
AS
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D052160:Benzothiazoles / Q000737:chemistry*; D002277:Carcinoma / Q000473:pathology*; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D015394:Molecular Structure; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D052160:Benzothiazoles; D010797:Phthalimides; C037431:phthalimide; D020169:Caspases