title: In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification.
abstract: Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.
authors.affiliation: Institute of Molecular Sciences and Bioinformatics, Lahore, Pakistan.
authors.forename: Ishtiaq
authors.initials: I
authors.lastname: Ahmad
authors.forename: Tehmina S
authors.initials: TS
authors.lastname: Khan
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Hoessli
authors.forename: Evelyne
authors.initials: E
authors.lastname: Walker-Nasir
authors.forename: Afshan
authors.initials: A
authors.lastname: Kaleem
authors.forename: Abdul R
authors.initials: AR
authors.lastname: Shakoori
authors.lastname: Nasir-ud-Din
mesh_terms: D000117:Acetylglucosamine / Q000737:chemistry* / Q000378:metabolism; D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003198:Computer Simulation; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D024241:HMGN1 Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment
chemical_list: D024241:HMGN1 Protein; D006657:Histones; D009707:Nucleosomes; D000117:Acetylglucosamine