[Acid-related disorders].
The diagnostic value of dyspeptic symptoms, various management strategies for dyspepsia and possible long-term consequences of acid inhibition is reviewed. In functional dyspepsia a uniform response to drug treatment is not likely, and acid suppression is not superior to placebo. A random starting day trial design identifies true drug response in a minority of patients. A symptom-driven management approach will reduce long term drug intake in reflux patients. The proportion of H. pylori-negative ulcers has increased; helicobacter status must be assessed in all ulcer patients.
Bytzer
Peter
P
Køge Sygehus, Medicinsk Afdeling, Gastroenterologisk Sektion, Køge. peter.bytzer@dadlnet.dk
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004415:Dyspepsia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors