[Assessment of bone quality. Effects of osteoporosis medications on structural and mechanical integrity of bone].
While mechanical strength of bone can be explained by measures of quantity up to 60 - 80%, several additional factors called 'quality' including microarchitecture have been proposed for better prediction of fracture risks. Osteoporosis medication can exert favorable effects on bone microarchitecture and strength, and has been evaluated by micro-CT using animal models. Studies are now moving toward the in vivo study using clinical imaging. Finite element analysis has been introduced for biomechanical evaluation of the bone, and this can be also applied to in vivo data. Several aspects of these basic and clinical researches will be discussed in this review.
Mawatari
Taro
T
Kyushu University, Graduate School of Medical Sciences, Department of Orthopaedic Surgery.
Miura
Hiromasa
H
Iwamoto
Yukihide
Y
Higaki
Hidehiko
H
D019386:Alendronate / Q000627:therapeutic use*; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D004195:Disease Models, Animal; D006801:Humans; D021621:Imaging, Three-Dimensional; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D019379:Teriparatide / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed / Q000379:methods*
D050071:Bone Density Conservation Agents; D019379:Teriparatide; D019386:Alendronate