Management of Cushing's disease using cavernous sinus sampling: effectiveness in tumor lateralization.
OBJECTIVE
The aim of this study was to determine the accuracy of bilateral cavernous sinus sampling (CSS) in preoperative tumor lateralization (right/left) within the pituitary in patients with Cushing's disease (CD).


METHODS
The study consisted of 26 consecutive patients who had undergone CSS followed by transsphenoidal surgery (TS) for CD between 2000 and 2006 at our institution. The magnetic resonance imaging (MRI) of the selected patients either revealed a normal pituitary or a lesion <or=6mm within the gland. Simultaneous bilateral CSS with corticotropin releasing hormone (CRH) stimulation were performed in all cases and the data was analyzed in relation to the results of the MRI studies, intraoperative and pathological findings and the outcome.


RESULTS
Early remission was achieved in 23 patients (88%) and CSS predicted the correct localization of the adenoma in 22 patients (85%). No lateralization (elevated levels in both sides) was detected during CSS in two patients, due to lesions within the central part of the pituitary. In four cases, there was a false positive lateralization, in which no microadenoma could be located in the lateralized side of the pituitary, resulting in no remission. There were no complications related to the CSS.


CONCLUSIONS
CSS in CD seems to be a valuable and safe diagnostic tool, which can predict the correct location of the pituitary adenoma in 85% of the cases.
Gazioglu
Nurperi
N
Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. nurperi@istanbul.edu.tr
Ulu
Mustafa Onur
MO
Ozlen
Fatma
F
Albayram
Sait
S
Islak
Civan
C
Kocer
Naci
N
Oz
Buge
B
Tanriover
Necmettin
N
Yetkin
Demet Ozgil
DO
Gundogdu
Sadi
S
Acbay
Ozer
O
Kadioglu
Pinar
P
D000236:Adenoma / Q000097:blood / Q000601:surgery*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002940:Circadian Rhythm; D003346:Corticotropin-Releasing Hormone; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007016:Hypophysectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D017591:Petrosal Sinus Sampling / Q000379:methods*; D047748:Pituitary ACTH Hypersecretion / Q000097:blood / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery*; D011237:Predictive Value of Tests; D011300:Preoperative Care; D013101:Sphenoid Sinus / Q000601:surgery
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone