title: Interactions between immune and biotransformation systems in fish: a review.
abstract: In animals biotransformation and immune system are not totally independent, there are numerous functional interrelationships between these two systems. They are both implicated in the capacity of organisms to resist to a wide variety of environmental components such as viruses, bacteria and xenobiotics. It is known for a long time that the immune system functions as a physiologic system and interacts with all the other components of the organism including nervous or endocrine ones. In the same manner, the biotransformation system (especially the cytochrome P450 monooxygenases) is involved in the regulation of numerous hormone productions. In this way, many studies in mammals have revealed the possible interaction between immune and biotransformation systems. Among these interactions, the capacity of the activation of host defense mechanisms to down-regulate microsomal cytochrome P450 and the role of biotransformation system in the xenobiotic-mediated immunotoxicity have been underlined. Advances in the basic knowledge of fish immune and biotransformation systems should lead to a better understanding of the possible interactions between both systems and should improve fish health monitoring which is a crucial ecotoxicological goal.
authors.affiliation: Laboratoire d'Ecologie Alpine, UMR CNRS No. 5553, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 09, France. stephane.reynaud@ujf-grenoble.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Reynaud
authors.forename: Muriel
authors.initials: M
authors.lastname: Raveton
authors.forename: Patrick
authors.initials: P
authors.lastname: Ravanel
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000276:immunology*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000276:immunology; D005399:Fishes / Q000276:immunology* / Q000378:metabolism*; D005786:Gene Expression Regulation; D007107:Immune System / Q000276:immunology*; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism; D015262:Xenobiotics / Q000633:toxicity
chemical_list: D018336:Receptors, Aryl Hydrocarbon; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System