title: A new route to indolines by the Cu-catalyzed cyclization reaction of 2-ethynylanilines with sulfonyl azides.
abstract: It is revealed that 2-sulfonyliminoindolines can be efficiently synthesized by the Cu-catalyzed cyclization reaction of N-alkyl- or aryl-substituted 2-ethynylanilines with sulfonyl azides. This new route to the indoline derivatives is characterized by mild reaction conditions, facile introduction of functional groups at the 2-position of the indoline ring, and the wide substrate scope. Selective transformation of indoline to oxindole and isatin analogs is also demonstrated.
authors.affiliation: Center for Molecular Design and Synthesis (CMDS), Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization
chemical_list: D000814:Aniline Compounds; D001386:Azides; D003300:Copper; C023650:aniline