The Ser9Gly polymorphism of the dopamine D3 receptor gene and risk of schizophrenia: an association study and a large meta-analysis.
Dopamine D3 receptor (DRD3) binds antipsychotic drugs and is abundant in the limbic system of the brain. It has been shown to play important roles in schizophrenia. A number of studies investigated the Ser9Gly polymorphism of the DRD3 gene to test its possible association with schizophrenia; however, the results were inconsistent. Our study aims to further evaluate the possible association between the Ser9Gly polymorphism and schizophrenia using a case-control association study within the Han Chinese population as well as a meta-analysis covering all previous studies. Our study, based on 329 schizophrenic patients and 288 controls, found no significant difference in the genotype or allele distributions of Ser9Gly polymorphism, the meta-analysis showed that the Ser9Gly polymorphism was not associated with Schizophrenia. Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia in the Chinese population.
Ma
Gang
G
Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China.
He
ZangDong
Z
Fang
WenLi
W
Tang
Wei
W
Huang
Ke
K
Li
ZhiQiang
Z
He
Guang
G
Xu
Yifeng
Y
Feng
GuoYin
G
Zheng
Tao
T
Zhou
Jian
J
He
Lin
L
Shi
YongYong
Y
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000235:genetics*; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D011110:Polymorphism, Genetic; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*; D012694:Serine / Q000235:genetics*
D050637:Receptors, Dopamine D3; D012694:Serine; D005998:Glycine