Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
Novel, achiral 1H-1,3,5-benzotriazepine-2,4(3H,5H)-diones have been prepared and structurally characterized. These compounds are potent CCK(2) receptor antagonists that display a high degree of selectivity over CCK(1) receptors.
Spencer
John
J
James Black Foundation, 68 Half Moon Lane, Dulwich, London SE24 9JE, UK.
Gaffen
John
J
Griffin
Eric
E
Harper
Elaine A
EA
Linney
Ian D
ID
McDonald
Iain M
IM
Roberts
Sonia P
SP
Shaxted
Mark E
ME
Adatia
Trushar
T
Bashall
Alan
A
D000818:Animals; D001552:Benzazepines / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding; D043887:Receptor, Cholecystokinin B / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*
D001552:Benzazepines; D043887:Receptor, Cholecystokinin B; D014227:Triazines