title: A comparison of the local effectiveness of mitomycin C, aprotinin, and Adcon-L in experimental peridural fibrosis.
abstract: BACKGROUND
  Peridural fibrosis and leptomeningeal adhesion formation are among the common causes of FBSS. Various materials have been used to prevent the compressive effect of postoperative PF on neural structures. We investigated and compared the effects of 3 agents--aprotinin, mitomycin C, and Adcon-L--to PF after lumbar laminectomy in rabbits.
  
  
  METHODS
  Four groups each including 8 rabbits were formed: Adcon-L, aprotinin, mitomycin C, and control groups. L3 laminectomy was performed on each animal. One of the 3 agents was administered locally to laminectomy areas in each group. All the animals were killed 4 weeks after the surgery. Peridural fibrosis, arachnoidal fibrosis, and dural adhesions were evaluated histologically and graded. The results were compared statistically by using a standard chi2 test.
  
  
  RESULTS
  There were significant differences in the PF grades among the experimental groups and the control group (P < .05). When the fibroblast density and the inflammatory cell density were evaluated, the grades of the experimental groups were better compared with the grades of the control group, but the difference was not statistically significant (P > .05).
  
  
  CONCLUSIONS
  Various materials have been used to prevent the compressive effect of postoperative PF on the neural structures. Aprotinin, mitomycin C, and Adcon-L are effective in preventing PF and dural adhesions in postlaminectomy areas. However, mitomycin C and Adcon-L were more effective than aprotinin in preventing peridural scarring.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Gazi, Ankara 06500, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kurt
authors.forename: Murat Hamit
authors.initials: MH
authors.lastname: Aytar
authors.forename: Fikret
authors.initials: F
authors.lastname: Doğulu
authors.forename: Berker
authors.initials: B
authors.lastname: Cemil
authors.forename: Ozlem
authors.initials: O
authors.lastname: Erdem
authors.forename: M Kemali
authors.initials: MK
authors.lastname: Baykaner
authors.forename: Necdet
authors.initials: N
authors.lastname: Ceviker
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004388:Dura Mater / Q000473:pathology; D004824:Epidural Space / Q000473:pathology*; D005355:Fibrosis; D007796:Laminectomy / Q000009:adverse effects*; D008159:Lumbar Vertebrae; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D009930:Organic Chemicals / Q000627:therapeutic use; D011817:Rabbits; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control
chemical_list: C104199:ADCON-L; D019384:Nucleic Acid Synthesis Inhibitors; D009930:Organic Chemicals; D015842:Serine Proteinase Inhibitors; D016685:Mitomycin; D007611:Aprotinin