title: Psychiatric manifestations in Wilson's disease: a cross-sectional analysis.
abstract: Behavioral and psychiatric abnormalities in Wilson's disease (WD) have a variable frequency and spectrum. This study involved evaluation of the psychiatric comorbidities in patients of Wilson's disease, using structured clinical interview for DSM-IV Axis-I disorders (SCID). Among the 50 confirmed patients with Wilson's disease recruited for this study, 12 patients (24%) fulfilled the diagnostic criteria for syndromic psychiatric diagnosis: bipolar affective disorder (18%), major depression (4%), and dysthymia (2%). Formal assessment of psychopathology in all patients with Wilson's disease may have therapeutic significance.
authors.affiliation: Department of Neurology, NIMH and Neurosciences (NIMHANS), Hosur Road, Bangalore-560 029, Karnataka, India.
authors.forename: A
authors.initials: A
authors.lastname: Shanmugiah
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: A B
authors.initials: AB
authors.lastname: Taly
authors.forename: L K
authors.initials: LK
authors.lastname: Prashanth
authors.forename: M
authors.initials: M
authors.lastname: Tomar
authors.forename: G R
authors.initials: GR
authors.lastname: Arunodaya
authors.forename: Janardhana Y C
authors.initials: JY
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Khanna
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D017831:Diagnosis, Dual (Psychiatry); D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006527:Hepatolenticular Degeneration / Q000453:epidemiology*; D006801:Humans; D007406:Interview, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D011569:Psychiatric Status Rating Scales