title: Cytomorphometric and immunohistochemical comparison between central and peripheral giant cell lesions of the jaws.
abstract: OBJECTIVE
  To determine whether cytomorphometric differences of multinucleated giant cells (MGCs) and CD68 reactivity of both MGCs and infiltrating macrophages may be associated with the clinical behavior of central and peripheral giant cell lesions of the jaws.
  
  
  METHODS
  Paraffin-embedded samples of central giant cell lesions (CGCLs; n = 20) and peripheral giant cell lesions (PGCLs; n = 20) were prepared for cytomorphometric analysis and immunohistochemistry.
  
  
  RESULTS
  The nuclei in CGCLs were more numerous, larger, and more irregular than those in PGCLs. Furthermore, CD68 expression and the ratio of CD68(+) macrophage to MGCs were significantly greater in CGCLs than in PGCLs. Statistical correlations between CD68 expression and the staining-intensity distribution score within the diagnostic groups were significant in CGCLs and not significant in PGCLs.
  
  
  CONCLUSIONS
  Although the CGCLs share some histopathologic similarities with PGCLs, differences in both nuclear morphometric parameters of MGC and CD68 immunoreactivity may underlie the distinct clinical behavior.
authors.affiliation: Department of Integrated Basic Studies, Medellín, Colombia.
authors.forename: Gloria Amparo
authors.initials: GA
authors.lastname: Flórez-Moreno
authors.forename: Marcela
authors.initials: M
authors.lastname: Henao-Ruiz
authors.forename: Diana Marcela
authors.initials: DM
authors.lastname: Santa-Sáenz
authors.forename: Diego Andrés
authors.initials: DA
authors.lastname: Castañeda-Peláez
authors.forename: Sergio Iván
authors.initials: SI
authors.lastname: Tobón-Arroyave
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D002467:Cell Nucleus / Q000473:pathology; D048430:Cell Shape; D048429:Cell Size; D002648:Child; D005260:Female; D005882:Gingival Diseases / Q000378:metabolism / Q000473:pathology*; D006101:Granuloma, Giant Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D007571:Jaw Diseases / Q000378:metabolism / Q000473:pathology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule