An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to alpha,beta-unsaturated aldehydes.
The addition of nitroalkanes to alpha,beta-unsaturated aldehydes under the catalysis of (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine and lithium acetate as additive afforded gamma-nitroaldehydes in good yield and up to 97% ee.
Wang
Yongcan
Y
Dalian Institute of Chemical Physics, Chinese Academy of Science, 457 Zhongshan Road, Dalian 116023, China.
Li
Pengfei
P
Liang
Xinmiao
X
Zhang
Tony Y
TY
Ye
Jinxing
J
D000447:Aldehydes / Q000737:chemistry*; D000473:Alkanes / Q000737:chemistry*; D017672:Nitrogen Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000473:Alkanes; D017672:Nitrogen Compounds