Octyl-methoxycinnamate (OMC), an ultraviolet (UV) filter, alters LHRH and amino acid neurotransmitters release from hypothalamus of immature rats.
OMC (octyl-methoxycinnamate), is an endocrine disruptor with estrogenic activity, which is used in sunscreen creams as a UV filter. We studied its " IN VITRO" effects on the hypothalamic release of LHRH as well as on the amino acid neurotransmitter system in immature rats of 15 (prepubertal) and 30 (peripubertal) days of age. OMC decreased the LH-RH release significantly in male and female rats of both age. In male rats OMC increased the release of GABA while in the female ones It diminished the excitatory amino acid aspartate (ASP) and Glutamate (GLU) without modifications in the hypothalamic GABA release. These results suggest that during sexual maturation the inhibitory effect of OMC on LH-RH release appears to be related to its action on the inhibitory and excitatory amino acid neurotransmitters in male and female rats.
Szwarcfarb
B
B
Facultad de Medicina, de Fisiología, Buenos Aires, Argentina. bertaburijson@yahoo.com.ar
Carbone
S
S
Reynoso
R
R
Bollero
G
G
Ponzo
O
O
Moguilevsky
J
J
Scacchi
P
P
D000818:Animals; D002934:Cinnamates / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D012741:Sexual Maturation / Q000187:drug effects*; D013473:Sunscreening Agents / Q000494:pharmacology; D014466:Ultraviolet Rays; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D002934:Cinnamates; D018846:Excitatory Amino Acids; D018377:Neurotransmitter Agents; D013473:Sunscreening Agents; D007987:Gonadotropin-Releasing Hormone; C118580:octylmethoxycinnamate; D005680:gamma-Aminobutyric Acid