Anti-Müllerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection.
OBJECTIVE
To evaluate anti-Müllerian hormone (AMH) as a marker of reproductive outcome after IVF/intracytoplasmic sperm injection (ICSI).


METHODS
Longitudinal study.


METHODS
University hospital.


METHODS
Two hundred seventy-six consecutive women undergoing IVF/ICSI.


METHODS
Ovarian stimulation, oocyte retrieval, IVF, ICSI, embryo transfer, AMH, and inhibin B determinations in serum and follicular fluid (FF).


METHODS
The AMH and inhibin B concentrations in 276 matched FF/serum pairs have been determined. Different outcome groups have been compared and set in relation to the oocyte count, morphological parameters, and steroid hormone levels.


RESULTS
The concentrations of AMH and inhibin B in both serum and FF were significantly higher in the group of women who became pregnant in the corresponding treatment cycle than in those who did not conceive. Positive correlations were observed between serum inhibin B concentrations and embryo morphology (r = 0.126, 95% confidence interval 0.026-0.284). Serum and FF AMH or inhibin B correlated positively with the oocyte count and negatively with the pretreatment cycle day 3 FSH level and the total administered gonadotropin dose.


CONCLUSIONS
The AMH and inhibin B levels on the day of oocyte retrieval are correlated to reproductive outcome.
Wunder
Dorothea M
DM
Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. dorothea.wunder@insel.ch
Guibourdenche
Jean
J
Birkhäuser
Martin H
MH
Bersinger
Nick A
NA
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D010064:Embryo Implantation; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007246:Infertility / Q000378:metabolism / Q000628:therapy*; D007265:Inhibins / Q000097:blood / Q000378:metabolism*; D008137:Longitudinal Studies; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; C422364:inhibin B; D011374:Progesterone; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone