Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview.
Sodium (Na) channels are essential for cardiac electrical activity. Cardiac Na channel dysfunction, inherited or acquired, can induce life-threatening conduction and arrhythmia disorders. Inherited Na channel dysfunction may put affected patients at a greater risk for these complications when channel-modifying drugs are prescribed. This study addressed pharmacogenetic effects in three well-described Na channel-related diseases: long QT syndrome type 3, Brugada syndrome and inherited cardiac conduction disease. A review of the currently available literature on cardiac Na channel-modulating drugs was undertaken. An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms.
Smits
Jeroen P P
JP
University of Amsterdam, Academic Medical Center, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Blom
Marieke T
MT
Wilde
Arthur A M
AA
Tan
Hanno L
HL
D000200:Action Potentials / Q000187:drug effects; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D053840:Brugada Syndrome / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D002317:Cardiovascular Agents / Q000009:adverse effects*; D004562:Electrocardiography; D020022:Genetic Predisposition to Disease; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009154:Mutation; D009206:Myocardium / Q000378:metabolism*; D010375:Pedigree; D010597:Pharmacogenetics; D011487:Protein Conformation; D012307:Risk Factors; D015222:Sodium Channels / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
D002317:Cardiovascular Agents; D015222:Sodium Channels