title: Neuroendocrine carcinoma of the liver and gallbladder in a cow.
abstract: A 15-year-old Limousin-cross cow was presented for examination with neurological signs and serum biochemical changes consistent with liver disease. Necropsy revealed enlargement of the liver with multifocal firm, depressed, pale, circumscribed lesions throughout the parenchyma. Within the gallbladder there were exophytic and villiform mucosal masses. Microscopically, hepatic structure was displaced by neoplastic cells forming trabeculae, nests and rosettes. There was transmural infiltration of the gallbladder by similar cells. The histological pattern of growth of the neoplastic cells, the presence of silver-stained cytoplasmic granules within these cells and the immunohistochemical demonstration of chromogranin A supported the diagnosis of neuroendocrine carcinoma. Bovine liver and gallbladder neuroendocrine carcinomas are rare and this is the first detailed documentation of the disease in the United Kingdom.
authors.affiliation: Pathology Unit, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone KT15 3NB, UK.
authors.forename: L K
authors.initials: LK
authors.lastname: Johnson
authors.forename: A
authors.initials: A
authors.lastname: Nunez
authors.forename: J R
authors.initials: JR
authors.lastname: Bracegirdle
authors.forename: J R
authors.initials: JR
authors.lastname: Dwyer
authors.forename: T
authors.initials: T
authors.lastname: Konold
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism / Q000473:pathology*; D053379:Chromogranin A / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000737:chemistry; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D005260:Female; D005704:Gallbladder / Q000473:pathology*; D005706:Gallbladder Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests / Q000662:veterinary; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008214:Lymphocytes / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009504:Neutrophils / Q000473:pathology; D016622:Silver Staining / Q000662:veterinary
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A