Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.
Sako
Kumiko
K
Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Aoyama
Hiroshi
H
Sato
Shinichi
S
Hashimoto
Yuichi
Y
Baba
Masanori
M
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D006801:Humans; D007536:Isomerism; D008745:Methylation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D002243:Carbolines; C055572:gamma-carboline