title: Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.
abstract: Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.
authors.affiliation: Department of Genomics, Life and Brain Center, University of Bonn, D-53127 Bonn, Germany. axel.hillmer@uni-bonn.de
authors.forename: Axel M
authors.initials: AM
authors.lastname: Hillmer
authors.forename: Antonia
authors.initials: A
authors.lastname: Flaquer
authors.forename: Sandra
authors.initials: S
authors.lastname: Hanneken
authors.forename: Sibylle
authors.initials: S
authors.lastname: Eigelshoven
authors.forename: Anne-Katrin
authors.initials: AK
authors.lastname: Kortüm
authors.forename: Felix F
authors.initials: FF
authors.lastname: Brockschmidt
authors.forename: Astrid
authors.initials: A
authors.lastname: Golla
authors.forename: Christine
authors.initials: C
authors.lastname: Metzen
authors.forename: Holger
authors.initials: H
authors.lastname: Thiele
authors.forename: Susanne
authors.initials: S
authors.lastname: Kolberg
authors.forename: Roman
authors.initials: R
authors.lastname: Reinartz
authors.forename: Regina C
authors.initials: RC
authors.lastname: Betz
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruzicka
authors.forename: Hans Christian
authors.initials: HC
authors.lastname: Hennies
authors.forename: Roland
authors.initials: R
authors.lastname: Kruse
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
mesh_terms: D000328:Adult; D017668:Age of Onset; D000505:Alopecia / Q000235:genetics*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005190:Family; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D008297:Male