Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
Aza TSAO-T derivatives bearing a substituted dihydroisothiazole dioxide ring with a phenyl group at 5'' position were prepared. Biological evaluation showed that phenyl group gives rise to a dramatical decrease of the inhibitory effect.
Tomassi
Cyrille
C
Laboratoire des Glucides (UMR6219), Faculté des Sciences, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France.
Nguyen Van Nhien
Albert
A
Marco-Contelles
José
J
Balzarini
Jan
J
Pannecouque
Christophe
C
De Clercq
Erik
E
Postel
Denis
D
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D001372:Aza Compounds; D009705:Nucleosides; D013141:Spiro Compounds