The biology and chemistry of the zoanthamine alkaloids.
Marine natural products have long played an important role in natural products chemistry and drug discovery. Mirroring the rich variety and complicated interactions of the marine environment, the substances isolated from sea creatures tend to be incredibly diverse in both molecular structure and biological activity. The natural products isolated from the polyps of marine zoanthids are no exception. The zoanthamine alkaloids, the first of which were isolated over 20 years ago, are of particular interest to the synthetic community because they feature a novel structural framework and exhibit a broad range of biological activities. In this Review, we summarize the major contributions to understanding the zoanthamine natural products with regard to their isolation and structure determination, as well as studies on their biological activity and total synthesis.
Behenna
Douglas C
DC
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, MC 164-30, Pasadena, CA 91125, USA.
Stockdill
Jennifer L
JL
Stoltz
Brian M
BM
D000470:Alkaloids / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001381:Azepines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D011804:Quinolines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000470:Alkaloids; D001381:Azepines; D001688:Biological Products; D006576:Heterocyclic Compounds, 4 or More Rings; D011804:Quinolines; C400280:norzoanthamine