title: Atenolol reduces salivary activity in pups of spontaneously hypertensive and normotensive rats treated during pregnancy and lactation.
abstract: The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance.
authors.affiliation: Pediatric Dentistry Postgraduate Program, School of Dentistry at Araçatuba, São Paulo State University, UNESP, SP, Brazil.
authors.forename: Gracieli P
authors.initials: GP
authors.lastname: Elias
authors.forename: Kikue T
authors.initials: KT
authors.lastname: Sassaki
authors.forename: Alberto C B
authors.initials: AC
authors.lastname: Delbem
authors.forename: Cristina
authors.initials: C
authors.lastname: Antoniali
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D005260:Female; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D007774:Lactation; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism* / Q000473:pathology; D012471:Salivary Proteins and Peptides / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D012471:Salivary Proteins and Peptides; D001262:Atenolol; D000681:Amylases