title: Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients.
abstract: The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P=0.004 and P=0.003, and P=0.01 and P=0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P=0.01 and P=0.02, respectively).
authors.affiliation: Department of Social Welfare with Addiction Rehabilitation, Eulji University, 143-5, Yangji-Dong, Sungnam, Kyounggi-do 461-713, Republic of Korea.
authors.forename: Keun-Ho
authors.initials: KH
authors.lastname: Joe
authors.forename: Dai-Jin
authors.initials: DJ
authors.lastname: Kim
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Sujung
authors.initials: S
authors.lastname: Yoon
authors.forename: Hae-Kook
authors.initials: HK
authors.lastname: Lee
authors.forename: Tae-Suk
authors.initials: TS
authors.lastname: Kim
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Cheon
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Gwon
authors.forename: Sung-Nam
authors.initials: SN
authors.lastname: Cho
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Suk
authors.initials: S
authors.lastname: Namgung
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000235:genetics*; D001007:Anxiety / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2