Genomics and the immune system.
While the hereditary information encoded in the Watson-Crick base pairing of genomes is largely static within a given individual, access to this information is controlled by dynamic mechanisms. The human genome is pervasively transcribed, but the roles played by the majority of the non-protein-coding genome sequences are still largely unknown. In this review we focus on insights to gene transcriptional regulation by placing special emphasis on genome-wide approaches, and on how non-coding RNAs, which derive from global transcription of the genome, in turn control gene expression. We review recent progress in the field with highlights on the immune system.
Pipkin
Matthew E
ME
Immune Disease Institute and Harvard Medical School, Boston, MA, USA.
Monticelli
Silvia
S
D000818:Animals; D004268:DNA-Binding Proteins / Q000276:immunology; D044127:Epigenesis, Genetic / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D023281:Genomics / Q000379:methods*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D009707:Nucleosomes / Q000276:immunology; D022661:RNA, Untranslated / Q000235:genetics; D014158:Transcription, Genetic / Q000276:immunology
D004268:DNA-Binding Proteins; D009707:Nucleosomes; D022661:RNA, Untranslated