title: The Southeast Asian Influenza Clinical Research Network: development and challenges for a new multilateral research endeavor.
abstract: The Southeast Asia Influenza Clinical Research Network (SEA ICRN) (www.seaclinicalresearch.org) is a recently developed multilateral, collaborative partnership that aims to advance scientific knowledge and management of human influenza through integrated clinical investigation. The partnership of hospitals and institutions in Indonesia, Thailand, United Kingdom, United States, and Viet Nam was established in late 2005 after agreement on the general principles and mission of the initiative and after securing initial financial support. The establishment of the SEA ICRN was both a response to the re-emergence of the highly pathogenic avian influenza A(H5N1) virus in Southeast Asia in late 2003 and an acknowledgment that clinical trials on emerging infectious diseases require prepared and coordinated research capacity. The objectives of the Network also include building sustainable research capacity in the region, compliance with international standards, and prompt dissemination of information and sharing of samples. The scope of research includes diagnosis, pathogenesis, treatment and prevention of human influenza due to seasonal or novel viruses. The Network has overcome numerous logistical and scientific challenges but has now successfully initiated several clinical trials. The establishment of a clinical research network is a vital part of preparedness and an important element during an initial response phase to a pandemic.
authors.affiliation: Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ehiggs@niaid.nih.gov
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Higgs
authors.forename: Frederick G
authors.initials: FG
authors.lastname: Hayden
authors.forename: Tawee
authors.initials: T
authors.lastname: Chotpitayasunondh
authors.forename: Jimmy
authors.initials: J
authors.lastname: Whitworth
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
mesh_terms: D000818:Animals; D001210:Asia, Southeastern; D035843:Biomedical Research / Q000458:organization & administration; D021821:Communicable Diseases, Emerging / Q000188:drug therapy / Q000517:prevention & control*; D032921:Consensus; D003299:Cooperative Behavior; D004189:Disaster Planning; D004196:Disease Outbreaks; D028744:Ethics Committees, Research; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000472:pathogenicity; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*