title: Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia.
abstract: Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia. Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies.
authors.forename: Hiroshi I
authors.initials: HI
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Asai
authors.forename: Zenshiro
authors.initials: Z
authors.lastname: Tamaki
authors.forename: Akira
authors.initials: A
authors.lastname: Hangaishi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Chiba
authors.forename: Mineo
authors.initials: M
authors.lastname: Kurokawa
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000503:physiopathology; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D005077:Exanthema Subitum / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006410:Hematopoiesis; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D015614:Histiocytosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage / Q000009:adverse effects; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017254:Leukemic Infiltration / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D000914:Antibodies, Viral; D003561:Cytarabine; D000493:Allopurinol; D015255:Idarubicin