Composite hemangioendothelioma of the oral cavity: case report and review of the literature.
BACKGROUND
Composite hemangioendothelioma is a rare histopathologic feature, which is part of the hemangioendothelioma family. This is a heterogeneous group of vascular neoplasia with a high tendency to local relapse but a rare predisposition to metastatic spread. Composite hemangioendothelioma mainly affects adults and is usually localized in the distal extremity of the limbs. To date, only 1 case has been detected in the oral cavity.


METHODS
A case of composite hemangioendothelioma in a 38-year-old man is reported. The lesion was localized in the left cheek vestibular mucosa. It was surgically excised with a 1-cm safety margin. Reconstruction was performed with a platysma myocutaneous flap.


RESULTS
At present, the patient is free from recurrence. The aesthetic and functional outcomes are satisfactory.


CONCLUSIONS
This case demonstrates how a composite hemangioendothelioma histological diagnosis can be difficult to achieve. Furthermore, therapy must be surgical and excision should be wide.
Fasolis
Massimo
M
Division of Maxillo-Facial Surgery, Department of Clinical Physiopathology, University of Turin, Turin, Italy. massimo.fasolis@unito.it
Iaquinta
Caterina
C
Montesco
Maria Cristina
MC
Garzino-Demo
Paolo
P
Tosco
Paolo
P
Tanteri
Giulia
G
Bonandini
Elena
E
Ninfo
Vito
V
Berrone
Sid
S
D000328:Adult; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006390:Hemangioendothelioma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D019647:Oral Surgical Procedures / Q000379:methods; D035583:Rare Diseases; D019651:Plastic Surgery Procedures / Q000379:methods; D013524:Surgical Flaps; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome