Aurora B kinase expression in ependymal neoplasms.
Overexpression of Aurora B kinase, which regulates cell progression through mitosis and cytokinesis, has been shown to be associated with higher-grade tumors and shortened survival in astrocytomas. Aurora B expression was evaluated by immunohistochemistry in 32 ependymomas, 10 anaplastic ependymomas, 16 myxopapillary ependymomas, and 9 subependymomas. Aurora B expression was identified in 20 (62.5%) ependymomas, 5 (50%) anaplastic ependymomas, 1 (6.3%) myxopapillary ependymoma, and no subependymomas. The association between Aurora B expression and World Health Organization grade II/III tumors was statistically significant (P<0.0001). There was no difference in the level of Aurora B expression between ependymomas and anaplastic ependymomas. Aurora B expression was not associated with patient age, sex, tumor location, tumor recurrence, or death from tumor. In contrast to astrocytomas, elevated Aurora B expression in higher-grade ependymomas does not seem to correlate with clinical course, although it may be a potential target of Aurora kinase inhibitors.
Gibson
Sarah E
SE
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.
Zeng
Weifen F
WF
Weil
Robert J
RJ
Prayson
Richard A
RA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D064107:Aurora Kinase B; D064127:Aurora Kinases; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis*; D012737:Sex Factors
C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases