title: Daptomycin use in infants: report of two cases with peak and trough drug concentrations.
abstract: We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
authors.affiliation: Department of Pediatrics, Duke University, Durham, NC, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cohen-Wolkowiez
authors.forename: P B
authors.initials: PB
authors.lastname: Smith
authors.forename: D K
authors.initials: DK
authors.lastname: Benjamin
authors.forename: V G
authors.initials: VG
authors.lastname: Fowler
authors.forename: K C
authors.initials: KC
authors.lastname: Wade
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D017576:Daptomycin / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D016106:Methicillin Resistance / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin