title: Characterization of two novel HLA class I alleles: HLA-A*310103 and HLA-B*9531.
abstract: Two novel human leucocyte antigen (HLA) class I alleles were characterized by means of sequencing-based typing techniques. HLA-A*310103 was identified in a cord blood unit from a Caucasoid individual. The sequence of this allele is identical to that of HLA-A*310102 except for a silent mutation in exon 3 at position 480 (G --> A). HLA-B*9531 was found in a Caucasoid female patient registered on the heart transplantation waiting list in the North Italy Transplant programme. This new variant differs from HLA-B*1503 at position 572 (G --> C) in exon 3. This nucleotide change leads to an amino acidic substitution at codon 167 from tryptophan to serine.
authors.affiliation: Regenerative Medicine Department, Organ and Tissue Transplantation Immunology, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Frison
authors.forename: E
authors.initials: E
authors.lastname: Longhi
authors.forename: E
authors.initials: E
authors.lastname: Andreini
authors.forename: F
authors.initials: F
authors.lastname: Poli
authors.forename: M
authors.initials: M
authors.lastname: Scalamogna
mesh_terms: D000483:Alleles; D001483:Base Sequence; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens