title: Long-term follow-up of renal function in patients after surgery for obstructive uropathy.
abstract: In this prospective study, selected biochemical markers of glomerular and tubular function, proteinuria, and ultrasound findings in 62 pediatric patients who underwent surgery for obstructive uropathy were examined. Patients were younger than 12 months, normocreatininemic at the time of surgery, and examined at a mean age of 6.3+/-0.9 years. Out of the markers tested, serum concentration of cystatin C was significantly higher in patients when compared with the control group (p<0.001), and serum creatinine concentration was within reference interval in all patients. With respect to tubular function, 26% of patients had decreased concentration ability. Proteinuria was detected in 4.8% of patients. On ultrasound, 66.7% of kidneys after surgery had residual dilatation of the renal pelvis. The patients thrive well, and their somatic parameters do not differ from their peers. Half of the patients had one or more urinary tract infections from the date of surgery to the date of examination. Study results support the need for long-term nephrologic follow-up in patients after surgery for obstructive uropathy. The hypothesis that renal function in patients undergoing surgery aged younger than 3 or 6 months is better when compared with those aged 6 to 12 months has not been confirmed.
authors.affiliation: 1st Department of Pediatrics, University Children's Hospital, Comenius University in Bratislava, Bratislava, Slovakia. d_miklovicova@hotmail.com
authors.forename: Daniela
authors.initials: D
authors.lastname: Miklovicova
authors.forename: Olga
authors.initials: O
authors.lastname: Cervenova
authors.forename: Andrea
authors.initials: A
authors.lastname: Cernianska
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Jancovicova
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dedik
authors.forename: Alena
authors.initials: A
authors.lastname: Vasilenkova
mesh_terms: D001794:Blood Pressure; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D004108:Dilatation, Pathologic; D004775:Enuresis / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery*; D007671:Kidney Concentrating Ability; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects; D011446:Prospective Studies; D011507:Proteinuria / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D014517:Ureteral Obstruction / Q000503:physiopathology / Q000601:surgery*; D014552:Urinary Tract Infections / Q000209:etiology / Q000503:physiopathology; D013520:Urologic Surgical Procedures / Q000009:adverse effects*
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine