title: Ablative targeting of fatty-tissue using a high-powered diode laser.
abstract: OBJECTIVE
  Concerning current clinical practice, laser-assisted lipoplasty is still secondary to other procedures. In order to evaluate effects of thermal interaction with fatty-tissue, a near infrared diode laser was examined under reproducible conditions.
  
  
  METHODS
  Based on optical spectroscopy of fatty-tissue, a high-powered diode laser (lambda = 940 nm) was used to irradiate n = 59 fat samples of fresh corpses in non-contact mode. Thermal effects were histologically evaluated by computer based metric measurements. Calculated values included ablation rate (AR) and the ratio of cavity diameter to diameter of collateral damage (CCD(ratio)). Pearson's correlation and analysis of covariance (ANCOVA) were used for statistical evaluation. P values of less than 0.05 were considered to indicate statistical significance.
  
  
  RESULTS
  Regarding the conditions examined, irradiances from 250 to 400 W/cm(2) revealed both increased ablation capacities and decreased collateral damages. An average irradiance of 370+/-0 W/cm(2) shows an average CCD(ratio) of 2:1 and an average AR of 9.98+/-7.65 mm(3)/second.
  
  
  CONCLUSIONS
  Near infrared high-powered diode laser energy proved to be eligible for tissue protective ablation of fat in vitro. Further studies are necessary to improve efficiency and safety of this procedure.
authors.affiliation: Department of Plastic Surgery, Reconstructive and Hand Surgery, Burn Center, University Hospital, D-52074 Aachen, Germany. d.m.odey@t-online.de
authors.forename: Dan mon
authors.initials: Dm
authors.lastname: O'Dey
authors.forename: Andreas
authors.initials: A
authors.lastname: Prescher
authors.forename: Reinhart
authors.initials: R
authors.lastname: Poprawe
authors.forename: Sebastian
authors.initials: S
authors.lastname: Gaus
authors.forename: Sven
authors.initials: S
authors.lastname: Stanzel
authors.forename: Norbert
authors.initials: N
authors.lastname: Pallua
mesh_terms: D000273:Adipose Tissue / Q000473:pathology / Q000528:radiation effects*; D002102:Cadaver; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D054023:Lasers, Semiconductor; D019265:Spectroscopy, Near-Infrared; D013848:Thigh; D046509:Tissue Culture Techniques