title: Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors.
abstract: BACKGROUND
  Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis.
  
  
  METHODS
  In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V.
  
  
  RESULTS
  Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment.
  
  
  CONCLUSIONS
  Apoptosis can be quantified using (99m)Tc EC-annexin V.
authors.affiliation: Department of Experimental Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurihara
authors.forename: David J
authors.initials: DJ
authors.lastname: Yang
authors.forename: Massimo
authors.initials: M
authors.lastname: Cristofanilli
authors.forename: William D
authors.initials: WD
authors.lastname: Erwin
authors.forename: Dong-Fang
authors.initials: DF
authors.lastname: Yu
authors.forename: Saady
authors.initials: S
authors.lastname: Kohanim
authors.forename: Richard
authors.initials: R
authors.lastname: Mendez
authors.forename: E Edmund
authors.initials: EE
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D017304:Annexin A5 / Q000138:chemical synthesis; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000138:chemical synthesis; D011446:Prospective Studies; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D017304:Annexin A5; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C433841:technetium Tc 99m ethylenedicysteine annexin V