[Effect of mitogen-activated protein kinases and transcriptional factor c-Fos on estradiol signal transduction in the rat adrenocorticocytes].
Signal transduction mechanisms mediating estradiol regulatory signals in the adrenal cortex were studied in rats. The effect of estradiol benzoate treatment on corticosteroids secretion, levels of ERK1/2, JNK, p38 mitogen-activated protein kinases, transcription factors c-Jun and c-Fos in adrenal cortex were investigated. The level of ERK1/2 was increased 1.7-fold in adrenocortical tissue after injections (3 days, 100 mkg per rat) of estradiol. However, the level of p38 kinase and protein kinase JNK was not changed in these conditions. The transcription factor AP-1, which includes c-Fos and c-Jun factors, is involved in realization of estradiol signal transduction. The level of c-Fos protein raised 1.8-fold after estradiol treatment, c-Jun protein was not increased. We conclude that ERK1/2 kinase and transcriptional factor c-Fos mediate fast estrogen signal transduction in adrenocorticocytes.
Kovzun
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D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects*
D000305:Adrenal Cortex Hormones; D016760:Proto-Oncogene Proteins c-fos; C074283:estradiol 3-benzoate; D004958:Estradiol; D020928:Mitogen-Activated Protein Kinases