Thermodynamic and spectroscopic studies of Cu(II) and Ni(II) complexes with a new proline-threonine dipeptide ligand.
The interactions between a new proline-threonine dipeptide ligand with two metallic cations were investigated in aqueous solution. The metallic cations studied were the copper(II) and the nickel(II), which are involved in many biological processes. The combination of potentiometry, UV-visible spectrophotometry, EPR, and mass spectrometry was used to determine the formation constants of the complexes and their structure in solution. The complexation sites were identified using electronic absorption and EPR spectroscopies. Copper complexes were obtained as square planar or square pyramidal mononuclear species, whereas nickel complexes were obtained as dinuclear species with an octahedral geometry.
Boudesocque
Stéphanie
S
GRECI (Groupe de Recherche en Chimie Inorganique), Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France.
Damaj
Ziad
Z
Dupont
Laurent
L
Behr
Jean-Bernard
JB
Guillon
Emmanuel
E
D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D008024:Ligands; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011392:Proline; D013053:Spectrophotometry; D013816:Thermodynamics; D013912:Threonine
D004151:Dipeptides; D008024:Ligands; D009942:Organometallic Compounds; D013912:Threonine; D003300:Copper; D009532:Nickel; D011392:Proline