Pharmaconutrition with omega-3 fatty acids: status quo and further perspectives.
Beneficial rapid onset effects of omega-3 fatty acids from fish oil on host defense compensatory fit into the comprehensive pathophysiology of critical illness. Because of balanced pro- and anti-inflammatory effects on a variety of host defense subsystems even septic patients had earlier recovery and improved survival. This review focuses in a compressed view on the beneficial aspects of omega-3 fatty acid supplementation on diverse organ functions, host defense and on balanced pro - and anti-inflammatory effects. Clinical impact of fish oil based pharmaconutrition during critical inflammation processes and immune response in humans is thoroughly discussed.
Heller
Axel R
AR
Klinik für Anaesthesiologie und Intensivtherapie, Universitätsklinikum Carl Gustav Carus, Fetscherstrasse 74, D-01309 Dresden, Germany. axel.heller@mailbox.tu-dresden.de
D000818:Animals; D015777:Eicosanoids / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D044623:Nutrition Therapy / Q000379:methods*; D010538:Peritonitis / Q000473:pathology / Q000628:therapy; D015398:Signal Transduction / Q000187:drug effects
D015777:Eicosanoids; D015525:Fatty Acids, Omega-3