title: Incidence and risk factors for perioperative adverse respiratory events in children who are obese.
abstract: BACKGROUND
  Consistent with the increasing prevalence of obesity in the United States and many countries worldwide, anesthesiologists are now presented with a greater number of adult and pediatric patients who are significantly overweight. This prospective study was designed to examine the relation between age-adjusted body mass index, preoperative comorbidities, and perioperative outcome in children.
  
  
  METHODS
  Children aged 2-18 yr undergoing noncardiac elective procedures were classified as overweight or obese based on their age- and sex-adjusted body mass index. Information was elicited regarding patient demographics, presence of comorbidities, and anesthetic technique. Data regarding the incidence and severity of perioperative adverse events were collected prospectively.
  
  
  RESULTS
  Two thousand twenty-five children comprised the sample (1,380 normal weight, 351 overweight, and 294 obese). Obese children had a significantly higher prevalence of comorbidities than nonobese children, including asthma, hypertension, sleep apnea, and type II diabetes. Furthermore, obese children had a higher incidence of difficult mask ventilation, airway obstruction, major oxygen desaturation (>10% of baseline), and overall critical respiratory adverse events. Logistic regression analysis revealed several risk factors for adverse events, including procedures involving the airway, obesity, age younger than 10 yr, and a history of obstructive sleep apnea.
  
  
  CONCLUSIONS
  These results suggest that children presenting for elective surgical procedures who are obese have a greater prevalence of preexisting comorbid medical conditions and an increased incidence of perioperative adverse respiratory events compared with normal-weight children. Identification and awareness of risk factors for perioperative complications will be important in optimizing the anesthetic management of these children.
authors.affiliation: Department of Anesthesiology, Universityof Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA. atait@umich.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Tait
authors.forename: Terri
authors.initials: T
authors.lastname: Voepel-Lewis
authors.forename: Constance
authors.initials: C
authors.lastname: Burke
authors.forename: Amy
authors.initials: A
authors.lastname: Kostrzewa
authors.forename: Ian
authors.initials: I
authors.lastname: Lewis
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017558:Elective Surgical Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology; D011446:Prospective Studies; D012120:Respiration Disorders / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D012137:Respiratory System / Q000503:physiopathology; D012307:Risk Factors