Daptomycin use in infants: report of two cases with peak and trough drug concentrations.
We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
Cohen-Wolkowiez
M
M
Department of Pediatrics, Duke University, Durham, NC, USA.
Smith
P B
PB
Benjamin
D K
DK
Fowler
V G
VG
Wade
K C
KC
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D017576:Daptomycin / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D016106:Methicillin Resistance / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D017576:Daptomycin