title: Glycosides from the bark of Adina polycephala.
abstract: Four new dimeric phenolic glycosides (1- 4), a new iridoid diglycoside (5), and 15 known glycosides have been isolated from an ethanolic extract of the bark of Adina polycephala. Their structures were determined by spectroscopic and chemical methods. Compounds 1, 3, and 5 showed in vitro inhibitory activity against the release of beta-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Maoluo
authors.initials: M
authors.lastname: Gan
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Mingtao
authors.initials: M
authors.lastname: Liu
authors.forename: Weixia
authors.initials: W
authors.lastname: Song
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zi
authors.forename: Sujuan
authors.initials: S
authors.lastname: Wang
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005966:Glucuronidase / Q000187:drug effects / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D039823:Iridoids; D010972:Platelet Activating Factor; D005966:Glucuronidase