Pioglitazone and losartan modify hemodynamic and metabolic parameters and vascular prostanoids in fructose-overloaded rats.
This study analyzes the effects of losartan (AT1 blocker) and pioglitazone (insulin sensitizer), alone and in combination, in the fructose-overloaded rat, a model of metabolic syndrome. All treatments (nine weeks) reduced blood pressure and triglyceridemia and also restored the diminished release of vasodilator prostaglandins (prostacyclin in aorta and mesenteric vascular bed and prostaglandin E(2) in the latter). Pioglitazone, alone and in combination with losartan, reduced the release of the vasoconstrictor thromboxane in controls and fructose rats in both vascular preparations. In conclusion, although combination therapy and single treatments exerted similar effects, there may still be some advantage to the combined treatment.
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Cátedras de Anatomía Humana (Macro y Microscópica) y Farmacotecnia I, Facultad de Farmacia y Bioquímica, Instituto de Morfología JJ Naón, Argentina. horacio.peredo@gmail.com
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D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D004357:Drug Synergism; D011464:Epoprostenol / Q000378:metabolism; D005632:Fructose / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D008643:Mesentery / Q000098:blood supply; D047495:PPAR gamma / Q000819:agonists; D000077205:Pioglitazone; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D045162:Thiazolidinediones / Q000494:pharmacology*; D013931:Thromboxanes / Q000037:antagonists & inhibitors; D014280:Triglycerides / Q000097:blood
D047228:Angiotensin II Type 1 Receptor Blockers; D047495:PPAR gamma; D011453:Prostaglandins; D045162:Thiazolidinediones; D013931:Thromboxanes; D014280:Triglycerides; D005632:Fructose; D011464:Epoprostenol; D019808:Losartan; D015232:Dinoprostone; D000077205:Pioglitazone