title: Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow.
abstract: OBJECTIVE
  In this study, we aimed to investigate the relationship between T-786C polymorphism of the endothelial nitric oxide synthase (eNOS) gene and slow coronary flow (SCF).
  
  
  METHODS
  A total of 56 patients with SCF but otherwise normal coronary arteries (mean age 48+/-9 years) and 37 controls with normal coronary angiograms (mean age 50+/-12 years) were enrolled in the study. Screening for the eNOS T-786C polymorphism was performed by restriction fragment length polymorphism methodology.
  
  
  RESULTS
  In normal coronary artery and SCF groups, TT genotype frequency was 23 (62.2%) versus 22 (39.3%), TC heterozygote genotype frequency was 11 (29.7%) versus 30 (53.6%), and CC homozygote genotype frequency was 3 (8.1%) versus 4 (7.1%), respectively (P=0.07). In dominant model statistical analysis, total CC and CT genotype frequency in control and study groups was found to be 14 (37.3%) versus 34 (60.7%), respectively (P=0.025). A positive correlation was found between the mean thrombolysis in myocardial infarction frame count and C allele in patients with SCF (r=0.21, P=0.043).
  
  
  CONCLUSIONS
  We concluded that the T-786C polymorphism of eNOS gene might be a risk factor for the SCF.
authors.affiliation: Siyami Ersek Cardiovascular and Thoracic Surgery Center, Training and Research Hospital, Istanbul, Turkey. zeknurkalem@yahoo.com
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Nurkalem
authors.forename: Burak
authors.initials: B
authors.lastname: Tangurek
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Zencirci
authors.forename: Ahmet T
authors.initials: AT
authors.lastname: Alper
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aksu
authors.forename: Betul
authors.initials: B
authors.lastname: Erer
authors.forename: Sevket
authors.initials: S
authors.lastname: Gorgulu
authors.forename: Figen
authors.initials: F
authors.lastname: Ciloglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eren
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D017023:Coronary Angiography; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III