title: Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.
abstract: A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.
authors.affiliation: Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Khadijah M
authors.initials: KM
authors.lastname: Hindi
authors.forename: Tammy J
authors.initials: TJ
authors.lastname: Siciliano
authors.forename: Semih
authors.initials: S
authors.lastname: Durmus
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Panzner
authors.forename: Doug A
authors.initials: DA
authors.lastname: Medvetz
authors.forename: D Venkat
authors.initials: DV
authors.lastname: Reddy
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Hogue
authors.forename: Christine E
authors.initials: CE
authors.lastname: Hovis
authors.forename: Julia K
authors.initials: JK
authors.lastname: Hilliard
authors.forename: Rebekah J
authors.initials: RJ
authors.lastname: Mallet
authors.forename: Claire A
authors.initials: CA
authors.lastname: Tessier
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Cannon
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019117:Burkholderia / Q000187:drug effects* / Q000254:growth & development; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004583:Electrons; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D006571:Heterocyclic Compounds / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008745:Methylation; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D018030:Silver Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D018030:Silver Compounds; D014867:Water; C103100:silver acetate; C030011:carbene; D008697:Methane