Lifelong consumption of sodium selenite: gender differences on blood-brain barrier permeability in convulsive, hypoglycemic rats.
The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood-brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood-brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p<0.05), but the decrease was not significant in female rats (p>0.05). The blood-brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p<0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood-brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.
Seker
F Burcu
FB
Department of Physiology, Faculty of Dentistry, Istanbul University, Capa, Istanbul, Turkey. fbseker@istanbul.edu.tr
Akgul
Sibel
S
Oztas
Baria
B
D000818:Animals; D001794:Blood Pressure; D001812:Blood-Brain Barrier / Q000378:metabolism*; D005260:Female; D007003:Hypoglycemia / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000378:metabolism*; D012727:Sex Characteristics; D018038:Sodium Selenite / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D018038:Sodium Selenite