title: Histiocyte-rich reactive lymphoid hyperplasia of the liver: unusual morphologic features.
abstract: Reactive lymphoid hyperplasia (RLH) of the liver is a rare entity and has also been termed nodular lymphoid lesion or pseudolymphoma of the liver. We report a case of hepatic RLH exhibiting unusual histiocyte-rich histologic features in a 47-yr-old woman in conjunction with a renal cell carcinoma. A follow-up computed tomography scan was done 14 months after a right radical nephrectomy for renal cell carcinoma revealed a nodular lesion in segment 5 of the liver. The lesion was interpreted as metastatic renal cell carcinoma or hepatocellular carcinoma based on the history of the patient and radiologic findings. Wedge resection of segment 5 was done with sufficient distance from the mass. Microscopically, the lesion was composed predominantly of peculiar histiocytic proliferation and was characterized by lymphoid aggregates forming a lymphoid follicle with germinal centers. The present case and prior cases reported in the literature suggest that RLH of the liver appear to be a heterogenous group of reactive inflammatory lesions that are often associated with autoimmune disease or malignant tumors.
authors.affiliation: Department of Pathology, Chonbuk National University, Medical School, Institute for Medical Sciences and the Center for Healthcare Technology Development, Jeonju, Korea.
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Park
authors.forename: Kyu Yun
authors.initials: KY
authors.lastname: Jang
authors.forename: Young Kon
authors.initials: YK
authors.lastname: Kim
authors.forename: Baik Hwan
authors.initials: BH
authors.lastname: Cho
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Moon
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D008875:Middle Aged; D019310:Pseudolymphoma / Q000473:pathology*