title: Adipokines and insulin resistance during pregnancy.
abstract: Normal pregnancy has been characterized as a "diabetogenic state". On the other hand, the adipose tissue is now considered an active organ, capable of secreting substances such as adipokines, which may play a role in the pathogenesis of insulin resistance. Resistin, leptin serum and placental levels increase as pregnancy progresses, which is in contrast to levels of adiponectin. These levels correlate with the state of reduced insulin sensitivity often developed in the latter stages of pregnancy. The objective of this article is to review recent advances in our understanding of adipokines and insulin resistance during pregnancy.
authors.affiliation: Division of Research, Hospital of Obstetrics and Gynecology at Western Medical Center, Mexican Institute of Social Security, Jalisco, Mexico. postmen71@yahoo.com.mx
authors.forename: Ana Bertha
authors.initials: AB
authors.lastname: Zavalza-Gómez
authors.forename: Roberto
authors.initials: R
authors.lastname: Anaya-Prado
authors.forename: Ana Rosa
authors.initials: AR
authors.lastname: Rincón-Sánchez
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Mora-Martínez
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D054392:Adipokines; D007328:Insulin