Psychiatric comorbidity in epilepsy: a study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy.
We evaluated the frequency of psychiatric disorders (PDs) in a homogenous series of patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS), as compared with patients with juvenile myoclonic epilepsy (JME), aiming to determine possible differences in psychiatric diagnoses between these two epileptic syndromes. Data from 170 patients with refractory TLE-MTS and from 100 patients with JME were reviewed and compared. The prevalence of PDs was high in both groups of patients with epilepsy: PDs were present in 85 patients with TLE-MTS (50%) and 49 patients with JME (49%). Among the TLE-MTS group, mood (25.8%), psychotic (15.8%), and anxiety (14.1%) disorders were the most frequent diagnoses, whereas anxiety and mood disorders (23 and 19%, respectively) were the most common among patients with JME. Psychoses were significantly associated with MTS (P<0.01) and anxiety disorders with JME (P<0.05). These findings suggest the existence of an anatomic correlation between PDs and brain structures involved in both epilepsy syndromes.
Filho
Gerardo Maria de Araújo
GM
Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil.
Rosa
Vivianne Pellegrino
VP
Lin
Katia
K
Caboclo
Luís Otávio Sales Ferreira
LO
Sakamoto
Américo Ceiki
AC
Yacubian
Elza Márcia Targas
EM
D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D008875:Middle Aged; D020190:Myoclonic Epilepsy, Juvenile / Q000453:epidemiology*; D012189:Retrospective Studies; D012598:Sclerosis / Q000453:epidemiology; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000473:pathology*