title: Solitary pituitary sarcoidosis with normal endocrine function: case report.
abstract: Sarcoidosis is a multisystemic granulomatous disease characterized by noncaseating epithelioid granulomata that affects the lung in over 90% of patients and the central nervous system (CNS) in 5-9%. Neurosarcoidosis often occurs as multifocal meningeal and parenchymal lesions, and its diagnosis is particularly difficult in the absence of concomitant systemic disease. Hypothalamic-pituitary sarcoidosis occurs in fewer than 10% of patients with neurosarcoidosis and has been previously reported in association with profound endocrinological dysfunction. The authors report the case of a patient with isolated pituitary sarcoidosis who was first evaluated for visual symptoms and showed no preoperative endocrinological dysfunction or evidence of multisystemic or other CNS involvement. To the authors' knowledge, only 1 other such presentation is previously reported in the English literature. Such presentations are diagnostically and therapeutically challenging, and definitive diagnosis requires obtaining a biopsy specimen of the lesion with histological proof of noncaseating epithelioid granuloma, as well as the exclusion of other possible entities.
authors.affiliation: Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA. promod.pillai@osumc.edu
authors.forename: Promod
authors.initials: P
authors.lastname: Pillai
authors.forename: Abhik
authors.initials: A
authors.lastname: Ray-Chaudhury
authors.forename: Mario
authors.initials: M
authors.lastname: Ammirati
authors.forename: E Antonio
authors.initials: EA
authors.lastname: Chiocca
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology