title: Neurogenic bladder due to hypoxic-ischemic demyelination.
abstract: OBJECTIVE
  Hypoxia is commonly known to target neuronal cell bodies. Although myelin is a non-infrequent target, posthypoxic demyelination is a rarely described entity. We describe the case of a man who developed neurogenic bladder following a motor vehicle accident.
  
  
  METHODS
  Following a severe motor-vehicle accident involving massive blood loss, a 46-year-old man developed urinary urgency requiring catheterization, with hyperactive reflexes and bilateral Babinski signs on exam.
  
  
  RESULTS
  Magnetic resonance imaging of the brain and cervical cord revealed diffuse, isolated white matter signal abnormality in a symmetric, confluent distribution, extending inferiorly into the spinal cord, with changes consistent with bilateral Wallerian degeneration. Serologic and CSF evaluations were normal.
  
  
  CONCLUSIONS
  Unlike previous reports of hypoxic-ischemic demyelination, our patient lacked any cortical abnormalities, presumably due to isolated white matter changes. This report alerts physicians to the possibility of hypoxic-ischemic demyelination due to global hypoxia-ischemia as an etiologic factor for neurogenic bladder.
authors.affiliation: University of Michigan Health System, Neurology, Ann Arbor, MI 48109, USA. sindhur@med.umich.edu
authors.forename: Sindhu
authors.initials: S
authors.lastname: Ramchandren
authors.forename: David S
authors.initials: DS
authors.lastname: Liebeskind
mesh_terms: D000328:Adult; D003711:Demyelinating Diseases / Q000150:complications*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D001750:Urinary Bladder, Neurogenic / Q000209:etiology*