Fundus autofluorescence imaging of retinal dystrophies.
Fundus autofluorescence (FAF) is a non-invasive imaging technique that enables the visualization of lipofuscin changes in the retinal pigment epithelium. This study aims to illustrate the spectrum of FAF changes in a variety of retinal dystrophies. For this purpose, we examined patients with retinal dystrophies such as Stargardt disease, Best vitelliform macular dystrophy, and retinal dystrophies associated with mutations in the peripherin/RDS gene. All retinal dystrophies were confirmed by molecular genetic analysis. A broad range of characteristic FAF patterns was observed. Our results indicate that FAF imaging constitutes a useful additive tool in the diagnosis and follow-up of various retinal dystrophies.
Boon
Camiel J F
CJ
Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Philips van Leydenlaan 15, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Jeroen Klevering
B
B
Keunen
Jan E E
JE
Hoyng
Carel B
CB
Theelen
Thomas
T
D015862:Choroid Diseases / Q000175:diagnosis; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism; D008268:Macular Degeneration / Q000175:diagnosis; D018613:Microscopy, Confocal / Q000379:methods; D009887:Ophthalmoscopy / Q000379:methods; D012162:Retinal Degeneration / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000378:metabolism
D008062:Lipofuscin