title: The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis.
abstract: Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case-control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r(2) = 0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR = 0.81, 95% C.I. = 0.70-0.94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3.
authors.affiliation: Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
authors.forename: Fuencisla
authors.initials: F
authors.lastname: Matesanz
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández
authors.forename: Roger L
authors.initials: RL
authors.lastname: Milne
authors.forename: Maria
authors.initials: M
authors.lastname: Fedetz
authors.forename: Laura
authors.initials: L
authors.lastname: Leyva
authors.forename: Miguel
authors.initials: M
authors.lastname: Guerrero
authors.forename: Concepción
authors.initials: C
authors.lastname: Delgado
authors.forename: Miguel
authors.initials: M
authors.lastname: Lucas
authors.forename: Guillermo
authors.initials: G
authors.lastname: Izquierdo
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcina
mesh_terms: D001216:Asparagine / Q000235:genetics; D001224:Aspartic Acid / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics* / Q000378:metabolism*; D013030:Spain; D018709:Statistics, Nonparametric
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic; D001224:Aspartic Acid; D001216:Asparagine