Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification.
In practical positron emission tomography (PET) diagnosis, a shortened protocol is preferred for patients with brain disorders. In this study, the applicability of a shortened protocol as an alternative to the 90-min PET scan with [(11)C]SA4503 for quantitative sigma(1) receptor measurement was investigated. Tissue time-activity curves of 288 regions of interest in the brain from 32 [(11)C]SA4503-PET scans of 16 healthy subjects prior to and following administration of a selective serotonin reuptake inhibitor (fluvoxamine or paroxetine) were applied to two algorithms of quantitative analysis; binding potential (BP) was derived from compartmental analysis based on nonlinear estimation, and total distribution volume (tDV) was derived from Logan plot analysis. As a result, although both BP and tDV tended to be underestimated by the shortened method, the estimates from the shortened protocol had good linear relationships with those of the full-length protocol. In conclusion, if approximately 10% differences in the estimated results are acceptable for a specific purpose, then a 60-min measurement protocol is capable of providing reliable results.
Sakata
Muneyuki
M
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Kimura
Yuichi
Y
Naganawa
Mika
M
Ishikawa
Masatomo
M
Oda
Keiichi
K
Ishii
Kenji
K
Hashimoto
Kenji
K
Chihara
Kunihiro
K
Ishiwata
Kiichi
K
D000328:Adult; D001923:Brain Chemistry / Q000187:drug effects; D001931:Brain Mapping / Q000379:methods; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D002985:Clinical Protocols; D016666:Fluvoxamine / Q000494:pharmacology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D017374:Paroxetine / Q000494:pharmacology; D010879:Piperazines / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography / Q000592:standards*; D011869:Radioligand Assay / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D017480:Receptors, sigma / Q000032:analysis* / Q000737:chemistry; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D016666:Fluvoxamine; D017374:Paroxetine; D010879:Piperazines; D019275:Radiopharmaceuticals; D017480:Receptors, sigma; D017367:Selective Serotonin Reuptake Inhibitors; C101789:SA 4503