New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm.
Three new compounds: 2R,3R-pterosin L 3-O-beta-D-glucopyranoside (1), beta-D-xylopyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (2) and 4-O-benzoyl-beta-D-xylo-pyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (3), together with nine known compounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated from natural sources for the first time. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively.
Chen
Yung-Husan
YH
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. tony_chen72001@yahoo.com.tw
Chang
Fang-Rong
FR
Lu
Mei-Chin
MC
Hsieh
Pei-Wen
PW
Wu
Ming-Jiuan
MJ
Du
Ying-Chi
YC
Wu
Yang-Chang
YC
D002247:Carbon Isotopes; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D032495:Pteris / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D002247:Carbon Isotopes; D005960:Glucosides; D007189:Indans; D011522:Protons; D012717:Sesquiterpenes; C010772:pterosin; C586064:pterosin B