Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae.
Pestalotheols A-D ( 1- 4 ), four new metabolites, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis theae. The structures of these compounds were determined by NMR spectroscopy, and 1 is further confirmed by X-ray crystallography. The absolute configurations of compounds 1 and 3 were assigned by application of the modified Mosher method. Pestalotheol C ( 3) displayed an inhibitory effect on HIV-1 LAI replication in C8166 cells with an EC 50 value of 16.1 microM.
Li
Erwei
E
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China.
Tian
Renrong
R
Liu
Shuchun
S
Chen
Xulin
X
Guo
Liangdong
L
Che
Yongsheng
Y
D001203:Ascomycota / Q000737:chemistry*; D002681:China; D018360:Crystallography, X-Ray; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D006575:Heterocyclic Compounds, 3-Ring; C529353:pestalotheol C