title: Multifaceted intervention to improve diagnosis and treatment of osteoporosis in patients with recent wrist fracture: a randomized controlled trial.
abstract: BACKGROUND
  Older patients who experience a fragility fracture are at high risk of future fractures but are rarely tested or treated for osteoporosis. We developed a multifaceted intervention directed at older patients with wrist fractures (in the form of telephone-based education) and their physicians (in the form of guidelines endorsed by opinion leaders, supported by reminders) to improve the quality of osteoporosis care.
  
  
  METHODS
  In a randomized controlled trial with blinded ascertainment of outcomes, we compared our intervention with usual care (provision of printed educational materials to patients). Eligible patients were those older than 50 years of age who had experienced a wrist fracture and were seen in emergency departments and fracture clinics; we excluded those who were already being treated for osteoporosis. The primary outcome was bisphosphonate treatment within 6 months after the fracture. Secondary outcomes included bone mineral density testing, "appropriate care" (consisting of bone mineral density testing with treatment if bone mass was low) and quality of life.
  
  
  RESULTS
  We screened 795 patients for eligibility and randomly assigned 272 to the intervention (137 patients) or control (135 patients) group. The median age was 60 years; 210 (77%) of the subjects were women, and 130 (48%) reported a previous fracture as an adult. Six months after the fracture, 30 (22%) of the intervention patients, as compared with 10 (7%) of the control patients, were receiving bisphosphonate therapy for osteoporosis (adjusted relative risk [RR] 2.6, 95% confidence interval [CI] 1.3-5.1, p = 0.008). Intervention patients were more likely than control patients to undergo bone mineral density testing (71/137 [52%] v. 24/135 [18%]; adjusted RR 2.8, 95% CI 1.9-4.2, p < 0.001) and to receive appropriate care (52/137 [38%] v. 15/135 [11%]; adjusted RR 3.1, 95% CI 1.8-5.3, p < 0.001). There were no differences between the groups in other outcomes. One patient died, and 4 others experienced recurrent fracture.
  
  
  CONCLUSIONS
  A multifaceted intervention directed at high-risk patients and their physicians substantially increased rates of testing and treatment for osteoporosis. Nevertheless, more than half of the patients in the intervention group were not receiving appropriate care 6 months after their fracture, which suggests that additional strategies should be explored. (ClinicalTrials.gov trial register no. NCT00152321.).
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alta. me2.majumdar@ualberta.ca
authors.forename: Sumit R
authors.initials: SR
authors.lastname: Majumdar
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Finlay A
authors.initials: FA
authors.lastname: McAlister
authors.forename: Debbie
authors.initials: D
authors.lastname: Bellerose
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Russell
authors.forename: David A
authors.initials: DA
authors.lastname: Hanley
authors.forename: Don W
authors.initials: DW
authors.lastname: Morrish
authors.forename: Walter P
authors.initials: WP
authors.lastname: Maksymowych
authors.forename: Brian H
authors.initials: BH
authors.lastname: Rowe
mesh_terms: D015502:Absorptiometry, Photon / Q000706:statistics & numerical data; D000058:Accidental Falls; D000368:Aged; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D050723:Fractures, Bone / Q000209:etiology*; D019983:Guideline Adherence; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D014954:Wrist Injuries / Q000209:etiology*
chemical_list: D004164:Diphosphonates