title: Plasma glutathione levels are independently associated with gamma-glutamyltransferase activity in subjects with cardiovascular risk factors.
abstract: To investigate whether GGT (gamma-glutamyltransferase) is associated to specific redox patterns. GGT, total and reduced aminothiols and malondialdehyde, were measured in 150 subjects (83 males, 48 (39-56) years), with none, one or more risk factors. By univariable analysis GGT was positively associated with age (p =0.001), male gender (p <0.001), risk factor number (p <0.001), ACE-inhibitors (p =0.008), anti-platelet agents (p =0.029), atherothrombotic events (p =0.001), glucose (p =0.013), malondialdehyde (p =0.029), plasma total cysteine (p =0.046) and inversely associated with plasma total glutathione (p =0.001). By multivariable analysis only male gender (p <0.001), risk factor number (p <0.001) and glutathione (p <0.001) were independently associated with GGT activity. These findings suggest that an ongoing redox imbalance, in terms of decreased plasma glutathione, is associated with raised GGT activity in subjects with a greater risk factor burden.
authors.affiliation: CNR Clinical Physiology Institute-Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Sedda
authors.forename: Benedetta
authors.initials: B
authors.lastname: De Chiara
authors.forename: Marina
authors.initials: M
authors.lastname: Parolini
authors.forename: Raffaele
authors.initials: R
authors.lastname: Caruso
authors.forename: Jonica
authors.initials: J
authors.lastname: Campolo
authors.forename: Giuliana
authors.initials: G
authors.lastname: Cighetti
authors.forename: Renata
authors.initials: R
authors.lastname: De Maria
authors.forename: Aldo
authors.initials: A
authors.lastname: Sachero
authors.forename: Luigi
authors.initials: L
authors.lastname: Donato
authors.forename: Oberdan
authors.initials: O
authors.lastname: Parodi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000453:epidemiology*; D005783:Gender Identity; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010949:Plasma / Q000737:chemistry / Q000201:enzymology*; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D008315:Malondialdehyde; D005723:gamma-Glutamyltransferase; D005978:Glutathione