Discovery of heparin chemosensors through diversity oriented fluorescence library approach.
Two novel heparin sensors, Heparin Orange and Heparin Blue, were developed by a diversity oriented fluorescence library approach (DOFLA) from a benzimidazolium library; the discovered compounds showed remarkable properties and have the potential to be applied to monitoring heparin levels in clinical plasma samples for point-of-care detection.
Wang
Shenliang
S
Department of Chemistry, New York University, New York, New York 10003, USA.
Chang
Young-Tae
YT
D000925:Anticoagulants / Q000097:blood*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006493:Heparin / Q000097:blood*
D000925:Anticoagulants; D005456:Fluorescent Dyes; D006493:Heparin