Bicyclic polyketide lactones from Chinese medicinal ants, Polyrhacis lamellidens.
Two new bicyclic polyketide lactones, polyrhacitides A ( 1) and B ( 2), were isolated from Chinese medicinal ants, Polyrhacis lamellidens, which have been used as an effective therapeutic agent to treat rheumatoid arthritis and hepatitis in China. Their absolute structures were elucidated on the basis of spectroscopic analyses and chemical evidence. The occurrence of polyketides with similar structures in plants of the Lamiaceae, Lauraceae, and Staphyleaceae indicates their significance in the study of chemical ecology.
Jiang
Zhi-Hong
ZH
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China. zhjiang@hkbu.edu.hk
Yang
Qing-Xiong
QX
Tanaka
Takashi
T
Kouno
Isao
I
D000818:Animals; D001000:Ants / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry
D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; C529416:polyrhacitide A; C529417:polyrhacitide B