Tumour-immune cell interactions modulated by chemokines.
BACKGROUND
Chemokines are involved in almost all aspects of tumour establishment and progression.


OBJECTIVE
This review gives an insight into the complexity of chemokines and chemokine signalling in tumours, especially focusing on the tuning of the immune system within the tumour microenvironment.


METHODS
Experimental evidence from manipulation of the chemokine network in murine models and in vitro data are critically discussed, and the current status and potential future interventions therapeutically targeting chemokines for efficient and long-lasting tumour control in cancer patients are described.
Jöhrer
Karin
K
Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria. Karin.Joehrer@tkfi.at
Pleyer
Lisa
L
Olivier
Angelika
A
Maizner
Eva
E
Zelle-Rieser
Claudia
C
Greil
Richard
R
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D019707:Receptors, Chemokine / Q000378:metabolism / Q000502:physiology*
D018925:Chemokines; D019707:Receptors, Chemokine