title: [Acute Toxoplasma gondii infection affects the reproductive function of male mice].
abstract: OBJECTIVE
  To investigate the influence of acute Toxoplasma gondii infection on the reproductive function of male mice.
  
  
  METHODS
  Twenty-six adult male mice were randomized into an infection and a control group of equal number. Acute Toxoplasma gondii infection was induced in the testes of the former, while abdominal injection of normal saline given to the latter. Cell imprints and pathological sections were obtained to observe the pathological changes and Toxoplasma gondii invasion in the spermatogenic cells and to compare the testicular LDH-X, sperm concentration and motility and the number of deformed spermatozoa between the two groups.
  
  
  RESULTS
  The testicular LDH-X, sperm concentration and motility and the number of deformed spermatozoa were 53.19 +/- 18.04, (15.01 +/- 2.42) x 10(6)/ ml, (8.26 +/- 2.57) % and (17.69 +/- 11.91) % in the infection group, as compared with 68.71 +/- 17.79, (23.87 +/- 6.66) x 10(6)/ ml, (13.21 +/- 2.82) % and (11.30 +/- 6.60) % in the control, with significant differences between the two groups (P < 0 05).
  
  
  CONCLUSIONS
  Acute Toxoplasma gondii infection affects the reproductive function of male mice.
authors.affiliation: Reproductive Center, Wuxi Maternity and Child Care Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, China. lihua-sun@163.com
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Sun
authors.forename: Feng
authors.initials: F
authors.lastname: Fan
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
mesh_terms: D000208:Acute Disease; D000818:Animals; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D051379:Mice; D011897:Random Allocation; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*; D013737:Testis / Q000378:metabolism* / Q000469:parasitology / Q000473:pathology; D014123:Toxoplasmosis / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4