Homogeneous pd-catalyzed enantioselective decarboxylative protonation.
General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.
Marinescu
Smaranda C
SC
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Nishimata
Toyoki
T
Mohr
Justin T
JT
Stoltz
Brian M
BM
D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D011522:Protons; D013237:Stereoisomerism
D002264:Carboxylic Acids; D011522:Protons; D010165:Palladium