title: Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Overweight and obesity have been associated with better survival in patients with chronic obstructive pulmonary disease (COPD). On the other hand, excess body weight is associated with abnormal metabolic and inflammatory profiles that define the metabolic syndrome and predispose to cardiovascular diseases. This study was undertaken to evaluate the impact of overweight and obesity on the prevalence of the metabolic syndrome and on the metabolic and inflammatory profiles in patients with COPD.
  
  
  METHODS
  Twenty-eight male patients with COPD were divided into an overweight/obese group [ n = 16, body mass index (BMI) = 33.5 +/- 4.2 kg/m(2)] and normal weight group (n = 12, BMI = 21.1 +/- 2.6 kg/m(2)). Anthropometry, pulmonary function and body composition were assessed. The metabolic syndrome was diagnosed according to waist circumference, circulating levels of triglyceride and high-density lipoprotein cholesterol levels, fasting glycemia and blood pressure. C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), leptin and adiponectin plasma levels were measured.
  
  
  RESULTS
  Airflow obstruction was less severe in overweight/obese compared with normal weight patients (forced expiratory volume(1): 51 +/- 19% versus 31 +/- 12% predicted, respectively, P < 0.01). The metabolic syndrome was diagnosed in 50% of overweight/obese patients and in none of the normal weight patients. TNF-alpha, IL-6 and leptin were significantly higher in overweight/obese patients whereas the adiponectin levels were reduced in the presence of excess weight.
  
  
  CONCLUSIONS
  The metabolic syndrome was frequent in overweight/obese patients with COPD. Obesity in COPD was associated with a spectrum of metabolic and inflammatory abnormalities.
authors.affiliation: Clinique du Souffle, La Solane, Osséja, France.
authors.forename: M
authors.initials: M
authors.lastname: Poulain
authors.forename: M
authors.initials: M
authors.lastname: Doucet
authors.forename: V
authors.initials: V
authors.lastname: Drapeau
authors.forename: G
authors.initials: G
authors.lastname: Fournier
authors.forename: A
authors.initials: A
authors.lastname: Tremblay
authors.forename: P
authors.initials: P
authors.lastname: Poirier
authors.forename: F
authors.initials: F
authors.lastname: Maltais
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D001823:Body Composition; D002097:C-Reactive Protein / Q000032:analysis; D015897:Comorbidity; D006801:Humans; D007320:Inspiratory Capacity; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein