Placental growth factor (PlGF) is a surrogate marker in preeclamptic hypertension.
OBJECTIVE
To evaluate plasma levels of angiogenic factors and their association with preeclampsia.


METHODS
Twenty-three women with preeclampsia and nine normotensive pregnant women from the Maternity of Hospital das Clínicas of Belo Horizonte/MG-Brazil were assessed by National High Blood Pressure Education Program Working Group Creteria (NHBPEPWG). The plasma levels of vascular endothelial growth factor (VEGF) and Placental growth factor (PlGF) were determined by ELISA assay.


RESULTS
Plasma concentration of PlGF was 12-fold lower in preeclampsia versus non preeclampsia pregnancies. An inverse correlation was observed between PlGF plasma levels and mean arterial pressure (MAP); a decrease in 1pg/mL of PlGF resulted in 6.18 mm Hg increase in MAP.


CONCLUSIONS
These results indicate that PlGF is related to MAP in pregnant women.
Teixeira
Patrícia Gonçalves
PG
Fetal Medicine Center, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Cabral
Antônio Carlos Vieira
AC
Andrade
Silvia Passos
SP
Reis
Zilma Silveira Nogueira
ZS
da Cruz
Lívia Pieroni Barroso
LP
Pereira
Jacqueline Braga
JB
Martins
Breno Oliveira de Barcelos
BO
Rezende
Cezar Alencar de Lima
CA
D000328:Adult; D015415:Biomarkers; D001938:Brazil; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor