Risk factors for cervical cancer among HPV positive women in Mexico.
OBJECTIVE
To identify factors that are associated with an increased risk of developing high-grade cervical intraepithelial neoplasia (CIN) or cancer among human papillomavirus (HPV)-positive women in Mexico.


METHODS
A case-control study design was used. A total of 94 cases and 501 controls who met the study inclusion criteria were selected from the 7 732 women who participated in the Morelos HPV Study from May 1999 to June 2000. Risk factor information was obtained from interviews and from HPV viral load results. Odds ratios and 95 percent confidence intervals were estimated using unconditional multivariate regression.


RESULTS
Increasing age, high viral load, a young age at first sexual intercourse, and a low socio-economic status are associated with an increased risk of disease among HPV-positive women.


CONCLUSIONS
These results could have important implications for future screening activities in Mexico and other low resource countries.
Flores
Yvonne N
YN
Unidad de Investigación Epidemiológica y en Servicios de, Instituto Mexicano del Seguro Social, Morelos, México. yflores@jhsph.edu
Bishai
David M
DM
Shah
Keerti V
KV
Lazcano-Ponce
Eduardo
E
Lörincz
Attila
A
Hernández
Mauricio
M
Ferris
Daron
D
Salmerón
Jorge
J
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*