title: Pulse wave velocity is associated with metabolic syndrome components in CAPD patients.
abstract: BACKGROUND
  Overall, the proportion of deaths due to cardiovascular disease (CVD) reached 40-50% in dialysis patients. Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and CVD risk. Individual components of the metabolic syndrome (MetS) are well-established cardiovascular risk factors. Thus we conducted a cross-sectional study in continuous ambulatory peritoneal dialysis (CAPD) patients to explore the association of MetS components with PWV.
  
  
  METHODS
  Prevalent CAPD patients (n = 148, 63 M/85 F) were categorized according to the number of traits of the MetS into one of three groups (No MetS, Risk of MetS, MetS). Due to the effect of peritoneal dialysis (PD), waist circumference was not assessed. Aortic stiffness was assessed by carotid-femoral PWV (C-F PWV).
  
  
  RESULTS
  Patients' MetS trait numbers were positively associated with C-F PWV (r = 0.301, p < 0.01), pulse pressure (r = 0.256, p < 0.01), systolic blood pressure (r = 0.233, p < 0.01), and serum albumin (r = 0.205, p < 0.05). In a multivariate regression analysis, PWV was independently determined by age (p < 0.01) and MetS score (p = 0.01). Adjusted R(2) of the model was 0.24.
  
  
  CONCLUSIONS
  MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients.
authors.affiliation: Division of Nephrology, Peking University Third Hospital, Beijing, PR China.
authors.forename: Xing-wei
authors.initials: XW
authors.lastname: Zhe
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Xin-kui
authors.initials: XK
authors.lastname: Tian
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.forename: Li-tao
authors.initials: LT
authors.lastname: Cheng
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Chen
authors.forename: Jonas
authors.initials: J
authors.lastname: Axelsson
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011674:Pulse; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin