title: Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines.
abstract: Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.
authors.affiliation: Lo Ka Chung Centre for Natural Anti-cancer Drug Development (Laboratory B), Hong Kong Polytechnic University, Yuk Choi Road, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Stanton Hon Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Chung Hin
authors.initials: CH
authors.lastname: Chui
authors.forename: Marcus Chun Wah
authors.initials: MC
authors.lastname: Yuen
authors.forename: Eva
authors.initials: E
authors.lastname: Lin
authors.forename: Raymond Siu Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Fung Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Gregory Yin Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Wing Sze
authors.initials: WS
authors.lastname: Lam
authors.forename: Sau Hing
authors.initials: SH
authors.lastname: Chan
authors.forename: Kim Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Chor Hing
authors.initials: CH
authors.lastname: Cheng
authors.forename: Paul Bo Shan
authors.initials: PB
authors.lastname: Lai
authors.forename: Michael Wing Yiu
authors.initials: MW
authors.lastname: Yu
authors.forename: Filly
authors.initials: F
authors.lastname: Cheung
authors.forename: Johnny Cheuk On
authors.initials: JC
authors.lastname: Tang
authors.forename: Albert Sun Chi
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D052160:Benzothiazoles / Q000737:chemistry*; D002277:Carcinoma / Q000473:pathology*; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D015394:Molecular Structure; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D052160:Benzothiazoles; D010797:Phthalimides; C037431:phthalimide; D020169:Caspases