title: Comparing the mucoadhesivity and drug release mechanisms of various polymer-containing propranolol buccal tablets.
abstract: The aims were to compare the mucoadhesivity, controlled release properties, and release mechanisms of several polymeric systems of propranolol buccal tablets and to propose polymer(s) for formulation optimization. Mucoadhesivity differences in the polymer ranking between compacts and tablets were found. Mathematical models that best described the matrices were power law or a combination of the power law and Hopfenberg models. Poly acrylic acid (PAA), carboxymethyl cellulose (CMC), and poly ethylene glycol (PEG) in combination, were identified as suitable polymers for formulation optimization of a multipolymeric propranolol buccal tablet. Artificial neural networks were employed as a confirmatory approach to explicate that the selected polymers, in particular PAA, produced the most significant effect on the mean dissolution time and mucoadhesivity.
authors.affiliation: School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Ashmitha P
authors.initials: AP
authors.lastname: Munasur
authors.forename: Viness
authors.initials: V
authors.lastname: Pillay
authors.forename: Yahya E
authors.initials: YE
authors.lastname: Choonara
authors.forename: Irene
authors.initials: I
authors.lastname: Mackraj
authors.forename: Thirumala
authors.initials: T
authors.lastname: Govender
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D000278:Administration, Buccal; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D016503:Drug Delivery Systems; D008962:Models, Theoretical; D016571:Neural Networks, Computer; D011092:Polyethylene Glycols / Q000737:chemistry*; D011433:Propranolol / Q000008:administration & dosage / Q000737:chemistry*; D011786:Quality Control; D012995:Solubility; D013607:Tablets
chemical_list: D000180:Acrylic Resins; D000959:Antihypertensive Agents; D013607:Tablets; D011092:Polyethylene Glycols; C006903:carbopol 940; D011433:Propranolol; D002266:Carboxymethylcellulose Sodium