title: Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study.
abstract: BACKGROUND
  Imported falciparum malaria is characterized by a broad spectrum of potentially life-threatening complications that may arise even after initiation of appropriate antimalarial drug therapy. Hence, at Heidelberg University Hospital, all patients with newly diagnosed falciparum malaria are initially treated in the intermediate care unit (IMC) or intensive care unit (ICU). The present study was undertaken to evaluate critically the benefit of this strategy, which includes daily consultation with senior specialists in tropical medicine.
  
  
  METHODS
  We conducted a retrospective cohort study at the 14-bed combined IMC/ICU of a 1,685-bed university hospital. A cohort of 122 patients with imported falciparum malaria admitted from 1 January 1996 to 31 December 2003 was included.
  
  
  RESULTS
  Thirty-four patients (27.9%) developed complications, defined according to the current World Health Organization classification. Most patients (80.3%) studied did not take the recommended chemoprophylaxis against malaria. The majority of patients (89.3% [n = 109]) could be adequately treated in the IMC. Life-threatening complications requiring ICU support occurred in 13 patients (10.7%). All complications were successfully managed. Fifty-five patients (45.1%) fulfilling recently published criteria for outpatient treatment had an excellent therapeutic response and did not require ICU support.
  
  
  CONCLUSIONS
  This retrospective evaluation demonstrated favourable therapeutic results in hospitalized patients with imported falciparum malaria. Both initial treatment in the medical IMC/ICU and close collaboration between intensivists and specialists in tropical medicine may improve disease outcome among affected patients. Prospective studies are needed to confirm these preliminary findings.
authors.affiliation: Department of Internal Medicine IV (Gastroenterology, Infectious Diseases and Intensive Care Medicine), University Hospital Heidelberg, Im Neuenheimer Feld, D-69120 Heidelberg, Germany. Lukas_Schwake@gmx.net
authors.forename: Lukas
authors.initials: L
authors.lastname: Schwake
authors.forename: Judith Pamela
authors.initials: JP
authors.lastname: Streit
authors.forename: Lutz
authors.initials: L
authors.lastname: Edler
authors.forename: Jens
authors.initials: J
authors.lastname: Encke
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Stremmel
authors.forename: Thomas
authors.initials: T
authors.lastname: Junghanss
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000628:therapy; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D005260:Female; D005858:Germany; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D016015:Logistic Models; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008499:Medical Records; D010349:Patient Compliance; D012189:Retrospective Studies; D014195:Travel
chemical_list: D000962:Antimalarials