title: Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading.
abstract: The cytological Ki-67 expression measured on cytological samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETs) management. The aim of our study was to assess reliability of Ki-67 expression measured on cytological samples obtained by EUS-FNAC in patients with PETs. Eighteen patients with PETs underwent EUS-FNAC before surgery. Ki-67 expression was measured on FNACs and on histological sections. Using a cut-off of 2%, percent agreement of Ki-67 expression on cytological and histological samples was 89% (k-statistic: 0.78, 95% confidence intervals (95% CI): 0.5, 1.0). Using cut-off values of 2 and 10%, percent agreement was 78% (k-statistic: 0.65, 95% CI: 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples.
authors.affiliation: General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Via Olgettina 60, Milano, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Piani
authors.forename: Giulia M
authors.initials: GM
authors.lastname: Franchi
authors.forename: Chiara
authors.initials: C
authors.lastname: Cappelletti
authors.forename: Marina
authors.initials: M
authors.lastname: Scavini
authors.forename: Luca
authors.initials: L
authors.lastname: Albarello
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zerbi
authors.forename: Paolo
authors.initials: P
authors.lastname: Giorgio Arcidiacono
authors.forename: Emanuele
authors.initials: E
authors.lastname: Bosi
authors.forename: Marco F
authors.initials: MF
authors.lastname: Manzoni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002454:Cell Differentiation; D019160:Endosonography; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007340:Insulinoma / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D011300:Preoperative Care; D011379:Prognosis
chemical_list: D019394:Ki-67 Antigen