Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model.
In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H(2)O(2) generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.
Li
Min
M
Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.
Wang
Ao-Jin
AJ
Xu
Jian-Xing
JX
D017209:Apoptosis / Q000502:physiology; D020169:Caspases / Q000378:metabolism*; D002460:Cell Line; D045304:Cytochromes c / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D016877:Oxidants / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D016877:Oxidants; D017382:Reactive Oxygen Species; D045304:Cytochromes c; D006861:Hydrogen Peroxide; D020169:Caspases; D010100:Oxygen