Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension.
The importance of oxidative stress in hypertension has recently received increasing attention. The association between the incidence of hypertension and a super family of antioxidant enzymes, glutathione S-transferase (GST)A1, GSTM1 and GSTT1, polymorphisms was investigated in 468 Japanese participants in a health screening program. The frequency of the GSTA1*B allele carriers was significantly higher in hypertensive patients than normotensive participants [adjusted odds ratio (OR): 1.8; 95% confidence interval (CI): 1.1-2.9]. The risk of hypertension was significantly increased in the GSTA1*B allele carriers having also the GSTM1 null genotype or both the GSTM1 and GSTT1 null genotypes (adjusted OR: 2.4; 95% CI: 1.2-4.9; adjusted OR: 3.1; 95% CI: 1.0-9.5, respectively). This is the first report identifying the GSTA1*B allele as a genetic risk factor for hypertension. The determination of the GST genotypes may help in identifying individuals at high-risk for hypertension.
Oniki
Kentaro
K
Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan.
Hori
Masaharu
M
Takata
Keiji
K
Yokoyama
Tomoko
T
Mihara
Shuichi
S
Marubayashi
Toru
T
Nakagawa
Kazuko
K
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D007564:Japan; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C484555:GSTA1 protein, human