title: Coagulation abnormalities and complications after percutaneous liver biopsy in horses.
abstract: BACKGROUND
  Liver biopsy is useful in the diagnosis of liver disease in horses. However, bleeding is the major complication. Liver dysfunction can result in abnormalities in coagulation, although there is no definitive association between risk of hemorrhage after biopsy and coagulopathy in humans. Frequency of coagulopathies in horses with liver disease and the nature and frequency of complications after liver biopsy are not reported.
  
  
  OBJECTIVE
  To determine whether there is an association between coagulopathy and hemorrhage after liver biopsy in horses.
  
  
  METHODS
  Horses with suspected liver disease from which a liver biopsy had been obtained.
  
  
  METHODS
  Retrospective study. Variables indicative of coagulation were recorded. The frequency and nature of complications after biopsy were assessed using clinical and hematologic data. The association between abnormal coagulation variables and complications was assessed.
  
  
  RESULTS
  Seventy biopsies were obtained from 66 horses. At least 1 coagulation profile abnormality was identified in 58% of the 43 horses with histopathologically confirmed liver disease. Complications were observed in 4/32 monitored horses (33 biopsies). Three horses had a decrease in the packed cell volume suggestive of subclinical bleeding, and 1 horse developed a diaphragmatic hematoma. There was no association between coagulation profile abnormality and complications.
  
  
  CONCLUSIONS
  Abnormalities of coagulation are common in horses with liver disease. Liver biopsy appears to be a safe procedure in the horse. An abnormal coagulation profile is not clearly associated with an increased risk of complications after biopsy.
authors.affiliation: Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA. ijohns@rvc.ac.uk
authors.forename: I C
authors.initials: IC
authors.lastname: Johns
authors.forename: R W
authors.initials: RW
authors.lastname: Sweeney
mesh_terms: D000818:Animals; D001706:Biopsy / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000662:veterinary*; D006734:Horse Diseases / Q000175:diagnosis*; D006736:Horses; D008099:Liver / Q000473:pathology* / Q000601:surgery; D008107:Liver Diseases / Q000175:diagnosis / Q000662:veterinary*; D012189:Retrospective Studies