title: Analysis of serum levels of anti-Mullerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal status.
abstract: This study was undertaken to investigate age-dependent and postmenopausal changes in the serum levels of anti-Mullerian hormone (AMH), inhibin B, insulin-like growth factor (IGF)-I, IGF-binding protein-3 (IGFBP-3), and follicle-stimulating hormone (FSH), and to determine which of these markers best reflects the aging process in women. A total of 144 women aged 20-59 yr were enrolled in this cross-sectional study. Blood samples were obtained on cycle day 3 of regularly menstruating women (n=111), or at random in postmenopausal women (n=33). Data were analyzed with respect to premenopausal women age groups and compared in pre- and postmenopausal women. Area under the receiver operating characteristic curve (ROCAUC) analyses were performed to assess the ability of each marker to discriminate between the pre- and postmenopausal status. Serum levels of AMH, IGF-I, and IGFBP-3 decreased and serum levels of FSH increased significantly with age in premenopausal women. Serum luteinizing hormone (LH) was higher and inhibin B was lower in women in their 20-30's than in 40's. Serum levels of AMH and IGF-I showed a consistent decrease with all age groups. ROCAUC analysis showed that the diagnostic accuracy of AMH for menopausal status was similar to those of FSH, LH, and inhibin B, and was better than that of IGF-I. In conclusion, the serum AMH level appears to be the best marker of the aging process in premenopausal women.
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Shin
authors.forename: Jung Ryeol
authors.initials: JR
authors.lastname: Lee
authors.forename: Gyung Woon
authors.initials: GW
authors.lastname: Noh
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Kang
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007265:Inhibins / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007265:Inhibins; D007334:Insulin-Like Growth Factor I; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone