Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients.
OBJECTIVE
To evaluate the oxidative status and antioxidant defense in patients with acute lymphoblastic leukemia (ALL).


METHODS
We measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasmatic and erythrocyte thiol levels and serum vitamin E concentration. This study was performed on 80 children with ALL divided into 4 groups: just diagnosed, remission induction, remission maintenance and out-of-treatment.


RESULTS
TBARS levels and serum protein carbonylation were higher in ALL patients than in controls and reduced levels of antioxidants were found in these patients.


CONCLUSIONS
These findings may indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistence of oxidative stress in acute lymphoblastic leukemia.
Battisti
Vanessa
V
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, 97105-900 Santa Maria, RS, Brazil.
Maders
Liési D K
LD
Bagatini
Margarete D
MD
Santos
Karen F
KF
Spanevello
Rosélia M
RM
Maldonado
Paula A
PA
Brulé
Alice O
AO
Araújo
Maria do Carmo
Mdo C
Schetinger
Maria R C
MR
Morsch
Vera M
VM
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology
D000975:Antioxidants