Current understanding of fungal microflora in inflammatory bowel disease pathogenesis.
Inflammatory bowel diseases are a current and growing public health problem, with a prevalence that appears to be increasing in most countries and cultures. While most research into the triggering phenomenon has focused on the interaction between commensal bacteria and inflammatory bowel disease, enteric fungi may also be important in determining disease susceptibility. Herein we review what is known about enteric fungi and the mechanisms by which they and their dysregulation might be involved in triggering inflammatory diseases of the bowel.
Underhill
David
D
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Braun
Jonathan
J
D000818:Animals; D000908:Antibodies, Fungal; D003093:Colitis, Ulcerative / Q000276:immunology / Q000382:microbiology; D003424:Crohn Disease / Q000276:immunology / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000382:microbiology*; D051193:Toll-Like Receptors
D000908:Antibodies, Fungal; D051193:Toll-Like Receptors