Determinants of CRP level in statin-treated patients.
OBJECTIVE
All factors of the metabolic syndrome (MetS) are reported to be associated with elevated C-reactive protein (CRP) levels. As CRP levels have been found to decrease as a result of statin treatment, the present study was intended to explore the relationship between CRP and the MetS in statin treated patients.


METHODS
In this study, the relationship between the components of the MetS and CRP level were analysed and factors determining CRP were identified in patients with longstanding intensive lipid lowering therapy with known cardiovascular disease.


RESULTS
In this population CRP levels are still associated with the MetS, with waist circumference, fasting glucose level and smoking being the most important determinants of CRP levels.


CONCLUSIONS
CRP levels are still associated with the MetS in patients treated with intensive lipid lowering therapy.
Liem
A H
AH
Oosterschelde Ziekenhuizen, Goes, The Netherlands. anho@zeelandnet.nl
van de Woestijne
A P
AP
Zwinderman
A H
AH
Visseren
F L J
FL
Jukema
J W
JW
D000069059:Atorvastatin; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000187:drug effects* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D005464:Fluorobenzenes / Q000627:therapeutic use; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology; D008875:Middle Aged; D010865:Pilot Projects; D011743:Pyrimidines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D012307:Risk Factors; D000068718:Rosuvastatin Calcium; D019821:Simvastatin / Q000627:therapeutic use; D012907:Smoking; D013449:Sulfonamides / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D005464:Fluorobenzenes; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D002097:C-Reactive Protein; D000069059:Atorvastatin; D019821:Simvastatin