High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus.
In a series of three homologous and eight heterologous challenge experiments, it was shown that high potency vaccines against foot-and-mouth disease (FMD) serotype A can induce protection even against heterologous challenge infection with viruses that give low r-values with the vaccine strains. The challenge virus specific neutralizing antibody response on the day of challenge (21 days post vaccination) generally correlated with protection.
Brehm
K E
KE
Friedrich-Loeffler-Institute, Institute of Diagnostic Virology, Südufer 10, Greifswald-Insel Riems, Germany.
Kumar
N
N
Thulke
H-H
HH
Haas
B
B
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005536:Foot-and-Mouth Disease / Q000276:immunology / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D008297:Male; D009500:Neutralization Tests; D014765:Viral Vaccines / Q000276:immunology*
D014765:Viral Vaccines