Isocyanide-based multicomponent reactions in drug discovery.
This review describes recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery and summarizes the various chemotypes used to probe biological targets. In the past couple of years, IMCR-derived ligands have been used to develop agents against infectious diseases and to interfere with protein-protein interactions. Additionally, they were active against a variety of targets such as enzymes, GPCRs and ion channels. The rational for the chemical biologist to apply such diversity generating chemistries is also discussed.
Akritopoulou-Zanze
Irini
I
R4CP, AP10-101, Abbott Laboratories, Abbott Park, IL 60064-6099, USA. irini.zanze@abbott.com
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D003486:Cyanides / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding / Q000187:drug effects
D000890:Anti-Infective Agents; D003486:Cyanides; D004791:Enzyme Inhibitors