Rapid lipid enrichment in omega3 fatty acids: liver data.
The bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion to normal subjects was recently reported to enrich within 60 min the phospholipid content of leucocytes and platelets in long-chain polyunsaturated omega3 fatty acids. The present study, conducted in second generation omega3-depleted rats, aims at investigating whether such a procedure may also increase within 60 min the phospholipid content of omega3 fatty acids in cells located outwards of the bloodstream, in this case liver cells, and whether this coincides with correction of the perturbation in the liver triglyceride fatty acid content and profile otherwise prevailing in these rats. The results indicate that such is indeed the case and further suggest a cause-to-effect relationship between the two events.
Carpentier
Yvon A
YA
Laboratories of Experimental Hormonology and Surgery, Brussels Free University, Brussels, Belgium.
Peltier
Sebastien
S
Portois
Laurence
L
Sener
Abdullah
A
Malaisse
Willy J
WJ
D000818:Animals; D004075:Diglycerides / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005260:Female; D005395:Fish Oils / Q000378:metabolism; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism*; D008297:Male; D000069463:Olive Oil; D010743:Phospholipids / Q000378:metabolism; D010938:Plant Oils / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D004075:Diglycerides; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D000069463:Olive Oil; D010743:Phospholipids; D010938:Plant Oils; D014280:Triglycerides