title: Bioactive films on metallic surfaces for osteoconduction.
abstract: A fast and effective electrochemical method was developed to make a dense calcium phosphate films on titanium and stainless steel for hard tissue replacement. The surfaces of titanium and stainless steel were cathodically treated in an electrochemical cell. By controlling the treatment parameters, a film of 100-nm thickness was deposited on the metal surface in several minutes. The thin film was amorphous calcium phosphate containing octacalcium phosphate nuclei, and also dense and ductile. The treated metals were able to induce bioactive calcium phosphate deposition after immersion in simulated body fluid (SBF) for only 1 and 2 days. In vivo study was conducted by implanting the treated specimens of titanium and stainless steel in dog's femur cavity. The treated metallic surfaces showed good ability of osteoconduction. This surface treatment method can be potentially used to enhance bioactivity of any type of metallic surfaces.
authors.affiliation: School of Chemical Engineering, Sichuan University, Chengdu, China.
authors.forename: Qiyi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Leng
authors.forename: Xiong
authors.initials: X
authors.lastname: Lu
authors.forename: Renlong
authors.initials: R
authors.lastname: Xin
authors.forename: Xiudong
authors.initials: X
authors.lastname: Yang
authors.forename: Jiyong
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D004285:Dogs; D004563:Electrochemistry / Q000379:methods*; D020007:Implants, Experimental; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D013193:Stainless Steel / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; D014025:Titanium