[Synthesis and antimicrobial activity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoyl)-D,L-methionine].
In order to obtain new compounds with potential antimicrobial activity some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-methionine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-P-methylthioethyl)- delta2-5-oxazolinone with various sulfonamides. The chemical structure of the new sulfonamides was confirmed by elemental analysis data and IR and 1NMR spectral measurements. The compounds were also investigated for their antimicrobial activity using Staphylococcus aureus, Escherichia coli, Listeria monocytogenes and Proteus vulgaris strains.
Pintilie
Otilia
O
Universitatea Al. l. Cuza Iaşi, Facultatea de Chimie, Catedra de Chimie Organică şi Biochimie.
Sunel
V
V
Profire
Lenuţa
L
Pui
A
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects; D013058:Mass Spectrometry; D008715:Methionine / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests / Q000379:methods; D011514:Proteus vulgaris / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D008715:Methionine