Cis interactions of immunoreceptors with MHC and non-MHC ligands.
The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also with those on the same cell. These cis interactions are a feature of immunoreceptors that inhibit, rather than activate, cellular functions. Here, we review situations in which cis interactions have been observed, the characteristics of receptors that bind in trans and cis, and the biological roles of cis recognition.
Held
Werner
W
Ludwig Institute for Cancer Research, Lausanne Branch and University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. Werner.Held@licr.unil.ch
Mariuzza
Roy A
RA
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D011971:Receptors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens; D011971:Receptors, Immunologic