Intracellular calcium release from human platelets: different messengers for multiple stores.
Two separate Ca2+ stores have been reported in human platelets: the dense tubular system (DTS) and lysosome-like acidic organelles. Recent work has reported that Ca2+ release from the DTS is mediated by the generation of inositol 1,4,5-trisphosphate, whereas Ca2+ efflux from the acidic stores is mostly linked to nicotinic acid adenine dinucleotide phosphate. Platelet agonists release Ca2+ selectively from one or both stores, which provides additional insight into the complexity of Ca2+ signaling and the cellular functions activated. Here, we review the role of multiple Ca2+ mobilizing messengers and Ca2+ stores in the activation of specific functions in platelets in response to different physiologic agonists.
Jardín
Isaac
I
Department of Physiology, Cell Physiology Research Group, University of Extremadura, Cáceres 10071, Spain.
López
José J
JJ
Pariente
José A
JA
Salido
Ginés M
GM
Rosado
Juan A
JA
D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D011983:Receptors, Purinergic / Q000502:physiology; D018179:Receptors, Thrombin / Q000502:physiology; D017483:Receptors, Vasopressin / Q000502:physiology
D011983:Receptors, Purinergic; D018179:Receptors, Thrombin; D017483:Receptors, Vasopressin; D002118:Calcium