title: Beta-carotene-loaded nanostructured lipid carriers.
abstract: Nanostructured lipid carriers (NLC) technology was used to disperse hydrophobic beta-carotene in an aqueous phase. NLC are lipid nanoparticles with a particle matrix consisting of a blend of a liquid and solid lipid. They were produced by melting the lipid blend at 80 degrees C and dispersing it into a hot emulsifier solution. The aim of this study was to extend the limited knowledge of melt-emulsified lipidic colloids in food systems and to evaluate the feasibility for further applications as functional ingredient in beverages. Physical stability of the NLC suspension was examined at 2 different storage temperatures by measuring the particle size with photon correlation spectroscopy (PCS) and laser diffractometry (LD). All particles containing sufficient amounts of emulsifier were smaller than 1 microm (LD diameter 100%) at a mean particle size of around 0.3 microm (LD) for 9 wk at 20 degrees C and at least 30 wk at 4 to 8 degrees C. Differential scanning calorimetry (DSC) was used to study the solid state of the lipids both in the beta-carotene loaded PGMS and in the NLC particles. Propylene glycol monostearate (PGMS) when dispersed as NLC recrystallized up to 98% during storage time. Within the regarded period of 7 mo no polymorph transitions were observed. Furthermore, stability of the beta-carotene in water dependent on NLC concentration and tocopherol content was measured photospectrometrically to get an estimation of the behavior of NLC in beverages.
authors.affiliation: Dept. of Food Process Engineering, Technische Univ. Berlin, Faculty of Process Sciences, Amrumer Str. 32, 13353 Berlin, Germany. Anke.Hentschel@tu-berlin.de
authors.forename: A
authors.initials: A
authors.lastname: Hentschel
authors.forename: S
authors.initials: S
authors.lastname: Gramdorf
authors.forename: R H
authors.initials: RH
authors.lastname: Müller
authors.forename: T
authors.initials: T
authors.lastname: Kurz
mesh_terms: D001628:Beverages / Q000032:analysis; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D004337:Drug Carriers; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D005524:Food Technology; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D049329:Nanostructures; D010316:Particle Size; D013696:Temperature; D013997:Time Factors; D019207:beta Carotene / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D019207:beta Carotene