Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi.
Bacterial quorum sensing plays a very important role in the regulation of biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe for the first time the discovery of several boronic acids as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi.
Ni
Nanting
N
Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA.
Chou
Han-Ting
HT
Wang
Junfeng
J
Li
Minyong
M
Lu
Chung-Dar
CD
Tai
Phang C
PC
Wang
Binghe
B
D001897:Boronic Acids / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D053038:Quorum Sensing / Q000187:drug effects / Q000502:physiology*; D014733:Vibrio / Q000187:drug effects / Q000502:physiology*
D001897:Boronic Acids