[Changes of serum creatine kinase levels in children with Duchenne muscular dystrophy].
OBJECTIVE
Duchenne muscular dystrophy (DMD) usually occurs prior to 3 years old. The value of serum creatine kinase changes with clinical progression and age in patients with DMD. This study aimed to investigate the regularity in the changes of serum creatine kinase activities in children with DMD.


METHODS
Peripheral blood samples were obtained from 40 children with DMD (ranged from 3-14 years). Serum creatine kinase levels were assayed by kinetic UV test.


RESULTS
Serum creatine kinase level in the 40 DMD patients (ranged from 2 595- 45 495 U/L) was remarkably higher than the reference value (35-174 U/L). The highest serum creatine kinase level (average: 27750-31173 U/L) was found in 3-5 years old patients. Afterwards, serum creatine kinase level decreased with clinical progression and age, with a yearly average rate of decline was 8.7%.


CONCLUSIONS
Serum creatine kinase level reaches a peak between 3 and 5 years old and then reduces with increasing age in children with DMD. The characteristic changes of serum creatine kinase are suspected to reflect the rate of muscle decay.
Sun
Shun-Chang
SC
Department of Clinical Laboratory, People's Hospital of Bao'an District of Shenzhen, Shenzhen, Guangdong 518101, China. shunchangsun@sohu.com
Peng
Yun-Sheng
YS
He
Jing-Bo
JB
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000097:blood* / Q000188:drug therapy / Q000235:genetics
D000305:Adrenal Cortex Hormones; D003402:Creatine Kinase