[Mechanisms of mitogen-activated protein kinase pathway in male reproductive toxicity induced organochlorine pesticides].
Mitogen-activated protein kinase pathway may closely associated with cell growth, differentiation and apoptosis, it may play an important role in cell death. With growing evidences from in vitro test, recently it demonstrated that the MAPK play a key role in the reproductive toxicity induced organochlorine pesticides and also showed that the products of Reactive Oxygen Species (ROS) induced organochlorine pesticides in these process. The relationship between MAPK and their activation results in apoptosis induced organochlorine pesticides, for further clarification of the mechanism of male reproductive toxicity induced organochlorine pesticides.
Yu
Haige
H
MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Yang
Kedi
K
D000818:Animals; D005837:Genitalia, Male / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010575:Pesticides / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*
D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D020928:Mitogen-Activated Protein Kinases