Larvicidal effects of fungal Meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and Yellow fever.
The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1-7, previously obtained fungal secondary metabolites from Penicillium sp., against the third-instar larvae of A. aegypti. The lethal concentrations (LC(50) and LC(90)) of 1-7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC(50) value of 2.9 ppm, making it an attractive natural insecticide.
Geris
Regina
R
Instituto de Química, Universidade Federal da Bahia, Rua Barão de Geremoabo s/n, Ondina, Salvador - BA, 41950-350, Brasil. rmgeris@ufba.br
Rodrigues-Fo
Edson
E
Garcia da Silva
Heloísa Helena
HH
Garcia da Silva
Ionizete
I
D000330:Aedes / Q000187:drug effects*; D000818:Animals; D003715:Dengue / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D008968:Molecular Conformation; D009032:Mosquito Control / Q000379:methods*; D010407:Penicillium / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015004:Yellow Fever / Q000517:prevention & control*
D007306:Insecticides; D013729:Terpenes