1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.
In our ongoing investigation of the bioactive constituents from plants, two new lignans, magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol were isolated from heartwood of Streblus asper, along with three known lignans, magnolignan A, magnolol, and magnaldehyde D. 1D and 2D NMR experiments, including COSY, HMQC, and HMBC, and other spectroscopic methods, including UV, IR, and MS were used for the determination of the structures and NMR assignments. Primary bioassays showed that magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, 46.4 microM and 10.1 microM, 21.7 microM, respectively.
Li
Jun
J
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Zhang
Yan-Jun
YJ
Jin
Bai-Feng
BF
Su
Xiao-Jian
XJ
Tao
Yi-Wen
YW
She
Zhi-Gang
ZG
Lin
Yong-Cheng
YC
D017209:Apoptosis / Q000187:drug effects*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017705:Lignans / Q000008:administration & dosage* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D029586:Moraceae / Q000378:metabolism*; D011522:Protons; D014934:Wood / Q000737:chemistry*
D017705:Lignans; D011522:Protons