title: Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
abstract: Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.
authors.affiliation: Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sako
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoyama
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Baba
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D006801:Humans; D007536:Isomerism; D008745:Methylation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D002243:Carbolines; C055572:gamma-carboline