title: Cytotoxic hydrolyzable tannins from Balanophora japonica.
abstract: Four hydrolyzable tannins named balanophotannins D-G ( 1- 4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D ( 1) and F ( 3) were determined via the PGME method. Balanophotannin E ( 2) showed cytotoxicity to Hep G2 cancer cells with an IC 50 value of 4.22 microM.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, People's Republic of China. zhjiang@hkbu.edu.hk
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Wen
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shao-Yu
authors.initials: SY
authors.lastname: Wu
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Liu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwata
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hirose
authors.forename: Shuguang
authors.initials: S
authors.lastname: Wu
authors.forename: Isao
authors.initials: I
authors.lastname: Kouno
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031111:Balanophoraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D047348:Hydrolyzable Tannins; C529415:balanophotannin E