title: Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure.
abstract: OBJECTIVE
  To investigate the association of exposure to fine particulate matter (PM2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes.
  
  
  METHODS
  Forty-one workers were monitored over 24 hours during which baseline, postshift, bedtime, and next morning measurements were collected. Twenty-two workers participated as controls.
  
  
  RESULTS
  Linear regression was used to model pairwise change in u-8-isoprostane and u-8-OHdG: pre- to postshift, preshift to bedtime, postshift to bedtime, and postshift to next morning. In the models, pre- to postshift change in 8-OHdG was statistically significant, whereas postshift to bedtime change in 8-isoprostane showed an unexpected inverse relationship with PM2.5.
  
  
  CONCLUSIONS
  Acute welding exposure is associated with a postshift blunting of systemic inflammation in chronically exposed boilermakers, as measured by 8-isoprostane. The level of oxidative DNA damage as measured by 8-OHdG is less clear.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Nuernberg
authors.forename: Paul D
authors.initials: PD
authors.lastname: Boyce
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Cavallari
authors.forename: Shona C
authors.initials: SC
authors.lastname: Fang
authors.forename: Ellen A
authors.initials: EA
authors.lastname: Eisen
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D016902:Air Pollution, Indoor / Q000009:adverse effects; D015415:Biomarkers / Q000652:urine; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D016014:Linear Models; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress; D052638:Particulate Matter / Q000652:urine; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry; D014896:Welding
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D052638:Particulate Matter; C075750:8-epi-prostaglandin F2alpha; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine