title: Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity.
abstract: A novel 2,3-dioxygenated flavanone, erigeroflavanone ( 1), as well as eight known flavonoids and two known gamma-pyranone derivatives, were isolated from an ethyl acetate-soluble extract of the flowers of Erigeron annuus. The structure of compound 1 was elucidated by interpretation of spectroscopic data. All of the isolates were subjected to in vitro bioassays to evaluate their inhibitory activity against advanced glycation end products formation and rat lens aldose reductase.
authors.affiliation: Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
authors.forename: Nam Hee
authors.initials: NH
authors.lastname: Yoo
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Jeong Lim
authors.initials: JL
authors.lastname: Yoo
authors.forename: Yun Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Kim
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D049919:Erigeron / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D007723:Korea; D007908:Lens, Crystalline / Q000201:enzymology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D044950:Flavanones; D017127:Glycation End Products, Advanced; C529414:erigeroflavanone; D000449:Aldehyde Reductase