title: Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice.
abstract: Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl. In the present study, we investigated the effects of acteoside administration on serum uric acid levels in mice rendered hyperuricemic with the uricase inhibitor potassium oxonate. When administered orally for 3 days at doses of 50, 100 and 150 mg/kg, acteoside reduced serum uric acid levels by 15.2, 23.8 and 33.1%, respectively, relative to vehicle-treated hyperuricemic mice. Importantly, in non-hyperuricemic mice, the serum uric acid levels were not affected by acetoside treatment. Acteoside also inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity at all three doses. These results suggest that the hypouricemic action of acteoside may be attributable to its inhibition of XDH/XO activity.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
authors.forename: Cai Guo
authors.initials: CG
authors.lastname: Huang
authors.forename: Yan Jun
authors.initials: YJ
authors.lastname: Shang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian Rong
authors.initials: JR
authors.lastname: Zhang
authors.forename: Wen Jie
authors.initials: WJ
authors.lastname: Li
authors.forename: Bin Hua
authors.initials: BH
authors.lastname: Jiao
mesh_terms: D000818:Animals; D006027:Glycosides / Q000494:pharmacology*; D033461:Hyperuricemia / Q000097:blood*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010094:Oxonic Acid / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D032266:Scrophularia; D014527:Uric Acid / Q000097:blood*; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D014527:Uric Acid; C489337:potassium oxonate; D010094:Oxonic Acid; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase