title: WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines.
abstract: Mitochondrial fission and trafficking to dendritic protrusions have been implicated in dendritic spine development. Here, we show that Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1) controls depolarization-induced mitochondrial movement into dendritic spines and filopodia and regulates spine morphogenesis. Depolarization-induced degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant decreased inhibitory phosphorylation on WAVE1, depend on NMDA receptor activation. Thus, WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and spine morphogenesis.
authors.affiliation: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
authors.forename: Jee Young
authors.initials: JY
authors.lastname: Sung
authors.forename: Olivia
authors.initials: O
authors.lastname: Engmann
authors.forename: Merilee A
authors.initials: MA
authors.lastname: Teylan
authors.forename: Angus C
authors.initials: AC
authors.lastname: Nairn
authors.forename: Paul
authors.initials: P
authors.lastname: Greengard
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000818:Animals; D049229:Dendritic Spines / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology*; D007091:Image Processing, Computer-Assisted; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D034622:RNA Interference; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000378:metabolism*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; C114864:WASF1 protein, human; D051300:Wiskott-Aldrich Syndrome Protein Family