title: Renal involvement in childhood vasculitis.
abstract: OBJECTIVE
  Renal involvement comprises one of the major organ involvements in childhood vasculitis and has also an important role in the long term prognosis. The aim of this retrospective study was to analyze the demographic, clinical, laboratory features, and the treatment modalities of patients with vasculitis who had renal involvement.
  
  
  METHODS
  Patients with the diagnosis of vasculitis who had been followed in two pediatric nephrology centers between 1990 and 2005 were analyzed retrospectively. Patients with renal involvement were selected and further evaluated.
  
  
  RESULTS
  The study population consisted of 152 of 816 patients with vasculitis. Renal involvement was seen in 134 patients (17%) with Henoch-Schonlein purpura(HSP), 14 patients (45%) with polyarteritis nodosa(PAN), 3 patients with Takayasu arteritis (TA) (50%) and in 1 Wegener granulomatosis (WG) patient. The mean age of patients with renal involvement was 9.2 +/- 0.91 years in the HSP group. Hematuria with proteinuria was the most common renal finding and joint manifestations were seen less in this group. During the follow-up, only 1 patient developed chronic renal failure. Proteinuria, hematuria and aneurysms were seen in 26, 35 and 57% respectively in the PAN group. Only 1 patient (3.2%) had developed chronic renal failure. All 3 patients with TA had bilateral renal arterial involvement.
  
  
  CONCLUSIONS
  Renal involvement constitutes an important part of childhood vasculitides. With the institution of early and aggressive immunosuppressive treatment significant improvement in the long-term survival of these patients can be achieved.
authors.affiliation: Ministry of Health Diskapi Children's Hospital, Division of Pediatric Nephrology, Ankara, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Cakar
authors.forename: Z Birsin
authors.initials: ZB
authors.lastname: Ozçakar
authors.forename: Derya
authors.initials: D
authors.lastname: Soy
authors.forename: Yetiş
authors.initials: Y
authors.lastname: Uçar
authors.forename: Suat
authors.initials: S
authors.lastname: Fitöz
authors.forename: Nazli
authors.initials: N
authors.lastname: Kara
authors.forename: Nermin
authors.initials: N
authors.lastname: Uncu
authors.forename: Canan
authors.initials: C
authors.lastname: Atakan
authors.forename: Mesiha
authors.initials: M
authors.lastname: Ekim
authors.forename: Fatoş
authors.initials: F
authors.lastname: Yalçinkaya
mesh_terms: D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000453:epidemiology*; D008297:Male; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014657:Vasculitis / Q000453:epidemiology*