Diminished functional association between proximal and distal gastric motility in critically ill patients.
OBJECTIVE
This study examined the effects of critical illness on the relationship between proximal and distal gastric motor activity during fasting and duodenal nutrient stimulation.


METHODS
Prospective, case-controlled study.


METHODS
Ten critically ill patients and ten healthy volunteers.


METHODS
Concurrent proximal gastric (barostat) and antro-pyloro-duodenal (manometry) motility were recorded during fasting and during two 60-min duodenal nutrient infusions (Ensure at 1 kcal/min and 2 kcal/min) in random order, separated by a 2-h wash-out period.


RESULTS
Baseline proximal gastric volumes were similar between the two groups. At 10 min nutrient-induced fundic relaxation was lower in patients than healthy subjects (45 +/- 26 vs. 196 +/- 29 ml). In patients the frequency and volume amplitude of fundic waves were also lower. There were fewer propagated antral waves in patients than in healthy subjects during both fasting and nutrient infusion. These were more retrograde, shorter in length and associated with a pyloric contraction. The proportion of fundic waves followed by a distally propagated antral wave was significantly less in patients (0%, 0-8%) than controls 36% (11-44%).


CONCLUSIONS
In critical illness, in addition to impairment of proximal and distal gastric motor activity, the association between the two gastric regions is abnormal. This disturbance may interfere with meal distribution and further contribute to slow gastric emptying in these patients.
Nguyen
Nam Q
NQ
Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, North Terrace, SA, Australia. namphoung28@hotmail.com
Fraser
Robert J
RJ
Bryant
Laura K
LK
Chapman
Marianne
M
Holloway
Richard H
RH
D018806:APACHE; D000328:Adult; D016022:Case-Control Studies; D016638:Critical Illness; D004750:Enteral Nutrition; D005215:Fasting; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged