title: Failure of prophylactic zinc in Wilson disease.
abstract: Early institution of prophylactic therapy of asymptomatic Wilson disease patients can prevent the expression of the disease. Zinc is currently preferred therapy for presymptomatic patients. We report onset of symptomatic disease in a presymptomatic patient and deterioration of biochemical parameters in another, despite appropriate zinc therapy.
authors.affiliation: Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Mishra
authors.forename: Veena
authors.initials: V
authors.lastname: Kalra
authors.forename: Rachna
authors.initials: R
authors.lastname: Seth
mesh_terms: D001921:Brain / Q000473:pathology; D002648:Child; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017211:Treatment Failure; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D015032:Zinc