title: A high-throughput approach towards a novel formulation of fenofibrate in omega-3 oil.
abstract: A novel lipid formulation containing fenofibrate in omega-3 oil was developed using a novel high-throughput screening platform. The optimized formulation combines the cardiovascular health benefits from omega-3 oil with the potent lipid-regulating effect of fenofibrate. When tested against the current marketed product Tricor in healthy human volunteers, the new formulation was shown to be equivalent to Tricor.
authors.affiliation: TransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, MA 02421, United States.
authors.forename: Pasut
authors.initials: P
authors.lastname: Ratanabanangkoon
authors.forename: Hector
authors.initials: H
authors.lastname: Guzman
authors.forename: Orn
authors.initials: O
authors.lastname: Almarsson
authors.forename: Dina
authors.initials: D
authors.lastname: Berkovitz
authors.forename: Stephanie
authors.initials: S
authors.lastname: Tokarcyzk
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Straughn
authors.forename: Hongming
authors.initials: H
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D018592:Cross-Over Studies; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D011345:Fenofibrate / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D015394:Molecular Structure; D012995:Solubility
chemical_list: D004655:Emulsions; D005079:Excipients; D015525:Fatty Acids, Omega-3; D000960:Hypolipidemic Agents; D011345:Fenofibrate