Anti-inflammatory mechanism of Rungia pectinata (Linn.) Nees.
This study is to explore the inner anti-inflammatory mechanism of the ethanol extract of Rungia pectinata (Linn.) Nees. As a result, the ethanol extract of Rungia pectinata (Linn.) Nees could not only strongly reduce production of pro-inflammatory cytokines and mediators via blocking NF-kappaB activation but slightly promote release of anti-inflammatory mediator HO-1 and suppress IL-10 secretion. In conclusion, compared to Dexamethasone, Rungia pectinata (Linn.) Nees has not only similar effects on antagonizing pro-inflammatory mediators and cytokines but also mild effects on promoting production of anti-inflammatory mediators.
Zhao
Lei
L
Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Tao
Jun-Yan
JY
Zhang
Shu-Ling
SL
Jin
Feng
F
Pang
Ran
R
Dong
Ji-Hua
JH
Guo
Yuan-Jin
YJ
Ye
Pian
P
D027901:Acanthaceae; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000737:chemistry; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000037:antagonists & inhibitors; D051379:Mice; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D016328:NF-kappa B; D010936:Plant Extracts; D016753:Interleukin-10; D009569:Nitric Oxide; D000431:Ethanol; D051547:Heme Oxygenase-1; D051546:Cyclooxygenase 2