title: Phenotypic differences on the outcome of the host-parasite relationship: behavior of mice of the CBi stock in natural and experimental infections.
abstract: Investigation of defined animal models may help to elucidate the role of the host genetic background in the development and establishment of a parasitic infection. Four lines of mice obtained by disruptive selection for body conformation (CBi+, CBi-, CBi/C and CBi/L) and the unselected control line CBi were examined in their response to different parasites to assess whether these distinct genotypes showed differences in their resistance to natural and experimental parasitosis. Protozoans (Trichomonas muris and Spironucleus muris) and nemathelminths (Syphacia obvelata and Aspiculurus tetraptera) were found naturally parasitizing the mice's intestines. CBi/C and CBi were the only genotypes in which T. muris was found. CBi- was least resistant to S. muris. The helminth parasitic burden showed differences between sexes within genotypes (males had a higher burden than females) and among genotypes (CBi/L males had the lowest burden). CBi/L animals were also most resistant to experimental challenge with Heligmosomoides polygyrus and Trypanosoma cruzi. Since all the animals examined shared a common habitat throughout the study and were equally exposed to infection, the phenotypic differences in the natural enteroparasitism herein described evince genetic differences among lines in the host-parasite relationship. This interpretation is further supported by the differences in the response to the experimental challenge to H. polygyrus and T. cruzi.
authors.affiliation: Cátedra de Parasitología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
authors.forename: M D
authors.initials: MD
authors.lastname: Vasconi
authors.forename: P
authors.initials: P
authors.lastname: Malfante
authors.forename: A
authors.initials: A
authors.lastname: Bassi
authors.forename: C
authors.initials: C
authors.lastname: Giudici
authors.forename: S
authors.initials: S
authors.lastname: Revelli
authors.forename: R
authors.initials: R
authors.lastname: Di Masso
authors.forename: M T
authors.initials: MT
authors.lastname: Font
authors.forename: L
authors.initials: L
authors.lastname: Hinrichsen
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001947:Breeding; D005260:Female; D005767:Gastrointestinal Diseases / Q000235:genetics / Q000469:parasitology / Q000662:veterinary; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006374:Helminthiasis, Animal / Q000235:genetics / Q000469:parasitology*; D006790:Host-Parasite Interactions; D008297:Male; D051379:Mice; D011529:Protozoan Infections, Animal / Q000235:genetics / Q000469:parasitology*