title: Relationship between osteopontin and vascular calcifications in type 2 diabetic patients.
abstract: OBJECTIVE
  To measure circulating osteopontin levels in a cohort of type 2 diabetic patients and to determine whether osteopontin could be associated with lower limb arteries calcifications, either intimal (atherosclerotic) or medial (mediacalcinosis).
  
  
  METHODS
  Osteopontin was measured in 60 patients with type 2 diabetes who were subdivided in three groups: group 1 (n=19) was characterized by the absence of peripheral vascular calcifications on plain soft tissue radiograms; group 2 (n=18) presented intimal calcifications without mediacalcinosis; in group 3 (n=23), mediacalcinosis was the dominant pattern.
  
  
  RESULTS
  Osteopontin levels were significantly higher in patients with mediacalcinosis (558 ng/ml [140-2289], median [range]) than in subjects without vascular calcifications (337 [134-841], P = 0.024) or in individuals with intimal lesions (340 [140-1154], P = 0.05). No correlation was observed between osteopontin, glycaemic control or HOMA test results. Osteopontin was correlated with creatinine clearance (P = 0.037).
  
  
  CONCLUSIONS
  In type 2 diabetic patients, circulating levels of osteopontin were higher in the presence of medial calcifications than in subjects without vascular lesions or in individuals with calcifications limited to the intimal
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy Iaşi, School of Medicine, Vth Medical Clinic.
authors.forename: Maria
authors.initials: M
authors.lastname: Belovici
authors.forename: J
authors.initials: J
authors.lastname: Ketelslegers
authors.forename: M
authors.initials: M
authors.lastname: Buysschaert
authors.forename: G I
authors.initials: GI
authors.lastname: Pandele
authors.forename: Valerie
authors.initials: V
authors.lastname: Coninck
authors.forename: A
authors.initials: A
authors.lastname: Leblanc
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000209:etiology; D001530:Belgium; D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000097:blood* / Q000209:etiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology*
chemical_list: D015415:Biomarkers; D053495:Osteopontin