Severe hemolytic disease of the newborn due to anti-Di b treated with phototherapy and intravenous immunoglobulin.
The Di(b) antigen usually occurs with high incidence, except in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Di(b) is not severe and its clinical course is benign. We report a Korean neonate with severe hemolytic disease of the newborn caused by anti-Di(b). The phenotype and genotype of the Diego blood group system of the patient and his mother were Di(a+b+) and Di(a+b-), respectively. The mother's serum and eluate from the neonate's erythrocytes contained anti-Di(b). This case was successfully managed with phototherapy and high dose iv immunoglobulin. Since most commercial antibody detection panels do not contain Di(b-) red cells, it is important to consider anti-Di(b) in cases of hemolytic disease of the newborn caused by an antibody against a high frequency antigen.
Oh
Eun-Jee
EJ
Department of Laboratory Medicine, College of Medicine, Catholic University of Korea, 505 Banpo-dong Seocho-ku, Seoul, 137-040, South Korea. ejoh@catholic.ac.kr
Jekarl
Dong Wook
DW
Jang
Hyun-Sik
HS
Park
Hae-Il
HI
Park
Yeon-Joon
YJ
Choi
Hyun Ah
HA
Chun
Chung-Sik
CS
Kim
Yonggoo
Y
Kim
Hyung Hoi
HH
D001789:Blood Group Antigens / Q000276:immunology*; D004899:Erythroblastosis, Fetal / Q000276:immunology* / Q000628:therapy*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007231:Infant, Newborn; D008297:Male; D010789:Phototherapy
D001789:Blood Group Antigens; D016756:Immunoglobulins, Intravenous