Integrating hippocampus and striatum in decision-making.
Learning and memory and navigation literatures emphasize interactions between multiple memory systems: a flexible, planning-based system and a rigid, cached-value system. This has profound implications for decision-making. Recent conceptualizations of flexible decision-making employ prospection and projection arising from a network involving the hippocampus. Recent recordings from rodent hippocampus in decision-making situations have found transient forward-shifted representations. Evaluation of that prediction and subsequent action-selection probably occurs downstream (e.g. in orbitofrontal cortex, in ventral and dorsomedial striatum). Classically, striatum has been identified as a crucial component of the less-flexible, incremental system. Current evidence, however, suggests that striatum is involved in both flexible and stimulus-response decision-making, with dorsolateral striatum involved in stimulus-response strategies and ventral and dorsomedial striatum involved in goal-directed strategies.
Johnson
Adam
A
University of Minnesota, Neuroscience, Minneapolis, MN 55455, United States.
van der Meer
Matthijs A A
MA
Redish
A David
AD
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D009434:Neural Pathways / Q000502:physiology