title: Development of aortic aneurysm/dilatation during the followup of patients with giant cell arteritis: a cross-sectional screening of fifty-four prospectively followed patients.
abstract: OBJECTIVE
  Giant cell arteritis (GCA) may involve the aorta. Retrospective studies have demonstrated a higher prevalence of aortic aneurysm among patients with GCA compared with the general population. We investigated the prevalence of aortic aneurysm in a cohort of patients with biopsy-proven GCA using a defined protocol and assessed whether persisting low-grade disease activity is associated with higher risk of developing aortic aneurysm.
  
  
  METHODS
  Fifty-four patients with GCA (14 men and 40 women) were cross-sectionally evaluated after a median followup of 5.4 years (range 4.0-10.5 years). The screening protocol included a chest radiograph, abdominal ultrasonography scan, and computed tomography scan when aortic aneurysm was suspected or changes with respect to the baseline chest radiograph were observed. Clinical and laboratory data, corticosteroid requirements, and relapses were prospectively recorded.
  
  
  RESULTS
  Twelve patients (22.2%) had significant aortic structural damage (aneurysm/dilatation), 5 of them candidates for surgical repair. Aortic aneurysm/dilatation was more frequent among men (50%) than women (12.5%; relative risk 3.5, 95% confidence interval 1.53-8.01, P = 0.007). At the time of screening, patients with aneurysm/dilatation had lower serum acute-phase reactants, lower relapse rate, and needed shorter periods to withdraw prednisone than patients without aortic structural damage.
  
  
  CONCLUSIONS
  There is a substantial risk of developing aortic aneurysm/dilatation among patients with GCA. Our data do not support that aneurysm formation mainly results from persistent detectable disease activity. Additional factors including characteristics of the initial injury or the target tissue may also determine susceptibility to aortic aneurysm/dilatation.
authors.affiliation: Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: García-Martínez
authors.forename: José
authors.initials: J
authors.lastname: Hernández-Rodríguez
authors.forename: Pedro
authors.initials: P
authors.lastname: Arguis
authors.forename: Pilar
authors.initials: P
authors.lastname: Paredes
authors.forename: Marta
authors.initials: M
authors.lastname: Segarra
authors.forename: Ester
authors.initials: E
authors.lastname: Lozano
authors.forename: Carlos
authors.initials: C
authors.lastname: Nicolau
authors.forename: José
authors.initials: J
authors.lastname: Ramírez
authors.forename: Francesc
authors.initials: F
authors.lastname: Lomeña
authors.forename: Miguel
authors.initials: M
authors.lastname: Josa
authors.forename: Francesca
authors.initials: F
authors.lastname: Pons
authors.forename: Maria C
authors.initials: MC
authors.lastname: Cid
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001014:Aortic Aneurysm / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology