Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia.
We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derived from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, with proliferation of CD4(-) CD8+. The co-existence of two translocations involving both sex chromosomes in a case of T-PLL is rare. Chromosomal instability associated with the disease progression may have allowed the emergence of cell clones with translocations involving the sex chromosomes and the ring chromosome observed.
de Oliveira
F M
FM
Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. morato.oliveira@yahoo.com.br
Tone
L G
LG
Simões
B P
BP
Rego
E M
EM
Marinato
A F
AF
Jácomo
R H
RH
Falcão
R P
RP
D000328:Adult; D043171:Chromosomal Instability / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D006801:Humans; D015461:Leukemia, Prolymphocytic, T-Cell / Q000235:genetics*; D008297:Male; D012303:Ring Chromosomes; D032681:Spectral Karyotyping; D014178:Translocation, Genetic