Proline-mediated enantioselective construction of tetrahydropyrans via a domino aldol/acetalization reaction.
Highly enantioselective synthesis of tetrahydropyrans was accomplished via a domino proline-mediated aldol reaction/intramolecular acetal formation from an aldehyde and inexpensive aqueous tetrahydro-2H-pyran-2,6-diol as a five-carbon unit.
Hazelard
Damien
D
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Ishikawa
Hayato
H
Hashizume
Daisuke
D
Koshino
Hiroyuki
H
Hayashi
Yujiro
Y
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D011714:Pyrans; D011392:Proline