title: Concise synthesis of enantiomers of 4-aminobutane-1,2,3-triol.
abstract: A very efficient synthesis of (2R,3S) and (2S,3R)-4-aminobutane-1,2,3-triol has been developed using either d- or l-glucose as the starting material. A key step is the one-pot conversion of an aldehyde to an amide, the scope of which has been extended to include other carbohydrate-derived aldehydes.
authors.affiliation: Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, USA. ndunlap@mtsu.edu
authors.forename: Norma K
authors.initials: NK
authors.lastname: Dunlap
authors.forename: John
authors.initials: J
authors.lastname: Drake
authors.forename: Andrea
authors.initials: A
authors.lastname: Ward
authors.forename: Tracy L J
authors.initials: TL
authors.lastname: Salyard
authors.forename: Leah
authors.initials: L
authors.lastname: Martin
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002082:Butylamines / Q000138:chemical synthesis* / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D002082:Butylamines; D005947:Glucose