Three-dimensional microtomographic imaging of human brain cortex.
This paper describes an X-ray microtomographic technique for imaging the three-dimensional structure of the human cerebral cortex. Neurons in the brain constitute a neural circuit as a three-dimensional network. The brain tissue is composed of light elements that give little contrast in a hard X-ray transmission image. The contrast was enhanced by staining neural cells with metal compounds. The obtained structure revealed the microarchitecture of the gray and white matter regions of the frontal cortex, which is responsible for the higher brain functions.
Mizutani
Ryuta
R
Department of Applied Biochemistry, School of Engineering, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan. ryuta@keyaki.cc.u-tokai.ac.jp
Takeuchi
Akihisa
A
Uesugi
Kentaro
K
Ohyama
Masami
M
Takekoshi
Susumu
S
Osamura
R Yoshiyuki
RY
Suzuki
Yoshio
Y
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods*