[Effect of pineal gland peptides on morphofunctional structure of the pancreas in ageing].
A study of pineal gland peptides effect on morphology and functions of the pancreas in the model of premature ageing in rats was performed with respect to the need in methods for premature ageing prevention. Structural, morphological and functional alterations in pancreas tissue, suggesting premature ageing of the gland, were identified by methods of immunohistochemistry and electronic microscopy. There was registered a geroprotective effect of the pineal gland peptides on pancreas tissue, manifested in the resistance of the latter to the impact of stress factors entailing premature ageing.
Ryzhak
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Kostiuchek
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D019588:Aging, Premature / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D005934:Glucagon / Q000378:metabolism; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology / Q000502:physiology; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010455:Peptides / Q000494:pharmacology / Q000502:physiology; D010870:Pineal Gland / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism
D009842:Oligopeptides; D010455:Peptides; D013004:Somatostatin; C027437:epithalamin; D005934:Glucagon; C421253:alanyl-glutamyl-aspartyl-glycine