title: Gastrointestinal stromal tumour of the rectum: report of a case and review of literature.
abstract: Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CD117 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and non-metastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST.
authors.affiliation: Department of Oncology, Division of General and Oncological Surgery, University of Palermo, Via del Vespro 129, Palermo 90127, Italy.
authors.forename: Nello
authors.initials: N
authors.lastname: Grassi
authors.forename: Calogero
authors.initials: C
authors.lastname: Cipolla
authors.forename: Adriana
authors.initials: A
authors.lastname: Torcivia
authors.forename: Stefano
authors.initials: S
authors.lastname: Mandala
authors.forename: Giuseppa
authors.initials: G
authors.lastname: Graceffa
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bottino
authors.forename: Federica
authors.initials: F
authors.lastname: Latteri
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D003131:Combined Modality Therapy / Q000379:methods; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis; D011743:Pyrimidines / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit