title: Three-dimensional microtomographic imaging of human brain cortex.
abstract: This paper describes an X-ray microtomographic technique for imaging the three-dimensional structure of the human cerebral cortex. Neurons in the brain constitute a neural circuit as a three-dimensional network. The brain tissue is composed of light elements that give little contrast in a hard X-ray transmission image. The contrast was enhanced by staining neural cells with metal compounds. The obtained structure revealed the microarchitecture of the gray and white matter regions of the frontal cortex, which is responsible for the higher brain functions.
authors.affiliation: Department of Applied Biochemistry, School of Engineering, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan. ryuta@keyaki.cc.u-tokai.ac.jp
authors.forename: Ryuta
authors.initials: R
authors.lastname: Mizutani
authors.forename: Akihisa
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Uesugi
authors.forename: Masami
authors.initials: M
authors.lastname: Ohyama
authors.forename: Susumu
authors.initials: S
authors.lastname: Takekoshi
authors.forename: R Yoshiyuki
authors.initials: RY
authors.lastname: Osamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods*