title: Nanofibers and nanoparticles for orthopaedic surgery applications.
abstract: The ability of nanostructures to elicit altered cell behaviors, including cell adhesion, proliferation, orientation, motility, integrin expression, cytoskeletal organization, and modulation of intracellular signaling, has raised heightened interest in these materials for various biomedical applications, including orthopaedic repair and regeneration. Studies have demonstrated that nanofibrous structures can favorably modulate osteoblast, osteoclast, and fibroblast activities toward implant and/or scaffold materials. Nanomaterials based on silver nanoparticles have received significant attention. Apart from their unique wound-healing ability, silver nanoparticles also exhibit high antibacterial properties, making them potential candidates for use in the development of infection-resistant biomaterials.
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia, 415 LaneRoad, Box 800759, Charlottesville, VA 22908, USA. nair@virginia.edu
authors.forename: Lakshmi S
authors.initials: LS
authors.lastname: Nair
authors.forename: Cato T
authors.initials: CT
authors.lastname: Laurencin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D019637:Orthopedic Procedures; D011108:Polymers; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011108:Polymers