title: Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
abstract: Eight C-6-geranylflavonoids ( 1- 8) were isolated from an ethanol extract of Paulownia tomentosa fruits. Tomentodiplacone ( 1), 3'- O-methyl-5'-hydroxydiplacone ( 2), 3'- O-methyl-5'- O-methyldiplacone ( 3), and tomentodiplacone B ( 4) were obtained as new compounds, and 3'- O-methyldiplacol ( 5) was isolated for the first time from a natural source. The structures of these new compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy, and the absolute configurations of the compounds were determined by circular dichroism. The antibacterial activities of 1- 8 against seven bacteria and yeast were evaluated.
authors.affiliation: Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic. karel.mejkal@post.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Smejkal
authors.forename: Stanislav
authors.initials: S
authors.lastname: Chudík
authors.forename: Pavel
authors.initials: P
authors.lastname: Kloucek
authors.forename: Radek
authors.initials: R
authors.lastname: Marek
authors.forename: Josef
authors.initials: J
authors.lastname: Cvacka
authors.forename: Marie
authors.initials: M
authors.lastname: Urbanová
authors.forename: Ondrej
authors.initials: O
authors.lastname: Julínek
authors.forename: Ladislav
authors.initials: L
authors.lastname: Kokoska
authors.forename: Tereza
authors.initials: T
authors.lastname: Slapetová
authors.forename: Pavla
authors.initials: P
authors.lastname: Holubová
authors.forename: Ales
authors.initials: A
authors.lastname: Zima
authors.forename: Margita
authors.initials: M
authors.lastname: Dvorská
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002942:Circular Dichroism; D018153:Czech Republic; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D028083:Scrophulariaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids