Microwave reactions under continuous flow conditions.
Microwave chemistry has already impacted significantly on the everyday synthesis of organic molecules. The adoption and integration of this liberating technology has permitted a resurrection of many synthetic transformations that were previously considered too extreme in their conditions (temperatures, pressures, reaction times) to be synthetically useful. Furthermore, whole arrays of additional chemical transformations have been devised under microwave heating that allow access to more diverse chemical architectures via more expedient routes. Continuous flow processing of chemical intermediates taking advantage of the unique heating mechanism and characteristics of microwave irradiation will certainly be the next evolutionary step forward in this area. The synergistic combination afforded by the simultaneous application of these two core processing tools will enhance still further the synthetic capabilities of tomorrow's chemists. This short review aims to highlight the current developments and future potential offered by continuous flow microwave mediated synthesis.
Baxendale
Ian R
IR
Innovative Technology Centre (ACS), Department of Chemistry, Lensfield Road, Cambridge, UK. svl1000@cam.ac.uk
Hayward
John J
JJ
Ley
Steven V
SV
D002625:Chemistry, Organic / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D004867:Equipment Design; D006361:Heating; D008872:Microwaves; D008956:Models, Chemical; D014465:Ultrasonics