title: Aphasia during the acute phase in ischemic stroke.
abstract: OBJECTIVE
  We investigated the incidence, clinical characteristics, outcome and factors associated with aphasia and early improvement in acute ischemic stroke.
  
  
  METHODS
  We consecutively studied 855 patients with acute ischemic stroke who were admitted to our hospital within 48 h after onset and who were not comatose on admission. Assessment of aphasia was performed on admission (day 0) and day 10. We examined the incidence, severity, and subtypes of aphasia, and compared the clinical background of patients with and without aphasia on admission, and also those with and without early improvement by day 10. In addition, we investigated the independent factors associated with the presence of aphasia on admission and with early improvement.
  
  
  RESULTS
  Of the 855 patients, 130 (15.2%) had aphasia on admission. The National Institutes of Health Stroke Scale (NIHSS) on admission (OR 1.21; 95% CI 1.17-1.26) was a significant and independent factor associated with the presence of aphasia on admission. Early improvement was seen in 56 of 121 aphasic patients (46.3%) who were still alive on day 10. A history of hypercholesterolemia (OR 3.27; 95% CI 1.14-9.39) was a significant and independent factor associated with early improvement in aphasia during the acute phase and NIHSS on admission (OR 0.95; 95% CI 0.90-0.99) was marginally significant.
  
  
  CONCLUSIONS
  It is difficult to predict the outcome of aphasia within the first few days after the onset of ischemic stroke.
authors.affiliation: Department of Neurology, Stroke Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan. y.inatomix@silk.ocn.ne.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Inatomi
authors.forename: T
authors.initials: T
authors.lastname: Yonehara
authors.forename: S
authors.initials: S
authors.lastname: Omiya
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Uchino
mesh_terms: D000368:Aged; D001037:Aphasia / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D015994:Incidence; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications*