Surface activation leukocyte markers and humoral factors in cord blood of newborns at risk of early infection.
Due to immaturity of both specific and non-specific immune mechanisms, neonates are at risk of serious infections. The risk group definition is vague, clinical signs are non-specific and common laboratory markers are not as useful as in later ages, especially due to delayed reactions. In an attempt to find early, sensitive and specific markers, we assessed a defined set of surface leukocyte markers and humoral factors in cord blood. Several differences were noted--children in the risk group had a higher proportion of CD19+/23+, CD16+/64+, CD45RO cells and higher levels of IL-6. We find it promising that already at birth there are notable signs of reaction to infection and that a follow-up of a set of infectious markers could be useful to identify the children in need of antibiotic treatment and for diminishing unnecessary treatment.
Rozsíval
Pavel
P
Charles University in Prague, Faculty of Medicine, Hradec Králové. pavel.rozsival@seznam.cz
Parízková
Eva
E
Vokurková
Doris
D
Buriánková
Bozena
B
Andrýs
Ctira
C
D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood*; D012307:Risk Factors
D015703:Antigens, CD; D015415:Biomarkers; D015850:Interleukin-6