Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?
The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.
Vodovar
Nicolas
N
Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.
Schweisguth
François
F
D000818:Animals; D005647:Fucosyltransferases / Q000502:physiology*; D006801:Humans; D021381:Protein Transport / Q000502:physiology; D051880:Receptors, Notch / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D051880:Receptors, Notch; D005647:Fucosyltransferases