Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics.
The aim of the study was to show the difference in the pattern of inflammation, and Th1/Th2 polarization between asthmatic and non-asthmatic patients with CRS, specifically eosinophil activation, local IgE levels in the sinus fluid and tissue, and the severity of inflammation were measured. The maxillary sinus lavages, mucosal biopsies and bacteriological swabs were taken in 17 asthmatic and 36 non-asthmatic adult patients with CRS. The concentrations of IgE, eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase were analyzed and IgE+ cells, eosinophils, lymphocytes and plasma cells were counted. The granulocyte activation markers and IgE in sinus lavages, and the inflammatory and IgE+ cells counts were significantly higher in the asthmatics with the greatest difference in ECP and IgE concentrations. The tryptase concentrations did not differ, but only in the asthmatics they correlated significantly with the IgE concentrations and IgE+ cells count. Asthmatic patients present a distinct subgroup among the patients with chronic rhinosinusitis (CRS). The levels of the cellular markers and IgE in the sinus fluid differ from those of non-asthmatic patients with CRS. The activation of granulocytes (especially eosinophils), local IgE concentrations and the inflammatory cells infiltration are significantly higher in the asthmatics.
Vagic
Davor
D
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital "Sestre milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.
Ferencic
Zeljko
Z
Drvis
Petar
P
Geber
Goran
G
Dzidic
Senka
S
Baudoin
Tomislav
T
Kalogjera
Livije
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D047150:Eosinophil Cationic Protein / Q000378:metabolism; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D005500:Follow-Up Studies; D006098:Granulocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism; D011379:Prognosis; D011863:Radioimmunoassay; D012220:Rhinitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D012720:Severity of Illness Index; D012852:Sinusitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D015415:Biomarkers; D007073:Immunoglobulin E; D009195:Peroxidase; D047150:Eosinophil Cationic Protein