Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB.
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha. Rutin also lowers NF-kappaB activation in response to RANKL.
Kyung
Tae Wook
TW
Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea.
Lee
Ji Eun
JE
Shin
Hyun Hee
HH
Choi
Hye Seon
HS
D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology* / Q000187:drug effects*; D053245:RANK Ligand / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012431:Rutin / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000494:pharmacology
D016328:NF-kappa B; D053245:RANK Ligand; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D012431:Rutin