Pyranose N-glycosyl amines: emerging targets with diverse biological potential.
Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.
Norris
Peter
P
Department of Chemistry, Youngstown State University, 1 University Plaza, Youngstown, OH 44555, USA. pnorris@ysu.edu
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004798:Enzymes / Q000187:drug effects*; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000588:Amines; D001685:Biological Factors; D004798:Enzymes; D014230:Triazoles; D005947:Glucose