Campylobacter jejuni CsrA mediates oxidative stress responses, biofilm formation, and host cell invasion.
The putative global posttranscriptional regulator csrA was mutated in Campylobacter jejuni 81-176. The csrA mutant was attenuated in surviving oxidative stress. CsrA also contributed to biofilm formation and adherence to and invasion of INT407 intestinal epithelial cells, suggesting a regulatory role for CsrA in C. jejuni pathogenesis.
Fields
Joshua A
JA
Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1459 Laney-Walker Blvd., Augusta, GA 30912, USA.
Thompson
Stuart A
SA
D001422:Bacterial Adhesion / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms; D002169:Campylobacter Infections / Q000382:microbiology*; D016123:Campylobacter jejuni / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology*; D002460:Cell Line; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D007422:Intestines / Q000382:microbiology; D009154:Mutation; D018384:Oxidative Stress / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D014157:Transcription Factors