Looking for a synergic effect between NHCs and chiral P-ligands.
The issue of the added value of NHCs in asymmetric catalysis with respect to trusted chiral P-ligands was addressed: considering a prototypical asymmetric allylic alkylation reaction as a model, the association of a priori inhibiting and achiral NHCs with modular P-ligand resulted in enhancement of er up to 508% and increased rates.
Toselli
Nicolas
N
Université Aix-Marseille, ECM, Institut des Sciences Moléclaires de Marseille, CNRS UMR 6263, Avenue Escadrille Normandie Niemen, case A 62, F-13397 Marseille Cedex 20, France.
Martin
David
D
Buono
Gérard
G