title: Homogeneous pd-catalyzed enantioselective decarboxylative protonation.
abstract: General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Smaranda C
authors.initials: SC
authors.lastname: Marinescu
authors.forename: Toyoki
authors.initials: T
authors.lastname: Nishimata
authors.forename: Justin T
authors.initials: JT
authors.lastname: Mohr
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D011522:Protons; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D011522:Protons; D010165:Palladium