title: Numerical investigation and identification of susceptible sites of atherosclerotic lesion formation in a complete coronary artery bypass model.
abstract: As hemodynamics is widely believed to correlate with anastomotic stenosis in coronary bypass surgery, this paper investigates the flow characteristics and distributions of the hemodynamic parameters (HPs) in a coronary bypass model (which includes both proximal and distal anastomoses), under physiological flow conditions. Disturbed flows (flow separation/reattachment, vertical and secondary flows) as well as regions of high oscillatory shear index (OSI) with low wall shear stress (WSS), i.e., high-OSI-and-low-WSS and low-OSI-and-high-WSS were found in the proximal and distal anastomoses, especially at the toe and heel regions of distal anastomosis, which indicate highly suspected sites for the onset of the atherosclerotic lesions. The flow patterns found in the graft and distal anastomoses of our model at deceleration phases are different from those of the isolated distal anastomosis model. In addition, a huge significant difference in segmental averages of HPs was found between the distal and proximal anastomoses. These findings further suggest that intimal hyperplasia would be more prone to form in the distal anastomosis than in the proximal anastomosis, particularly along the suture line at the toe and heel of distal anastomosis.
authors.affiliation: Thermal and Fluids Engineering Division, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, 639798, Singapore. tslzjm@nus.edu.sg
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Zhang
authors.forename: Leok Poh
authors.initials: LP
authors.lastname: Chua
authors.forename: Dhanjoo N
authors.initials: DN
authors.lastname: Ghista
authors.forename: Simon Ching Man
authors.initials: SC
authors.lastname: Yu
authors.forename: Yong Seng
authors.initials: YS
authors.lastname: Tan
mesh_terms: D000714:Anastomosis, Surgical; D001783:Blood Flow Velocity; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000209:etiology*; D006083:Graft Occlusion, Vascular / Q000209:etiology*; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow