title: Assessment of diastolic function using 16-frame 201Tl gated myocardial perfusion SPECT: a comparative study of QGS2 and pFAST2.
abstract: OBJECTIVE
  The objective of the present study is to investigate the correlations across various types of interface software for (201)Tl gated myocardial perfusion SPECT (MPS) in calculating two common diastolic function parameters (DFx), peak-filling rates (PFR), and time-to-peak filling (TTPF).
  
  
  METHODS
  A total of 109 patients (66 men and 43 women; age 35-78 years) were studied. All patients were classified into three groups (i.e., ND, no-defect group; SD, small-defect group; LD, large-defect group) to clarify the influence of perfusion defects possibly affecting the analysis. Two kinds of available software, namely, quantitative gated SPECT (QGS2) and perfusion and functional analysis for gated SPECT (pFAST2) with cardioGRAF were used to obtain PFR and TTPF. Finally, we analyzed the correlation between DFx obtained with the two different kinds of software.
  
  
  RESULTS
  The values of LVEF, PFR, and TTPF were assessed in all patients. In both the ND (correlation coefficients were 0.92, 0.79, and 0.99, respectively) and SD groups (correlation coefficients were 0.74, 0.88, and 0.98, respectively), a strong correlation was observed. In contrast, PFR did not show a significant correlation in the LD group.
  
  
  CONCLUSIONS
  With the two different kinds of software, QGS2 and pFAST2, the calculated PFR was almost equal and showed good correlations in both ND and SD groups. In contrast, the numerical value varied between the two methods, and its correlation was poor in the LD group. However, TTPF showed a good correlation regardless of the presence of perfusion defects, and the values were equal. TTPF was confirmed to be a stable diastolic index across the two kinds of software, QGS2 and pFAST2, in (201)Tl gated MPS.
authors.affiliation: Department of Radiology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. snagama@med.miyazaki-u.ac.jp
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nagamachi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Wakamatsu
authors.forename: Seigo
authors.initials: S
authors.lastname: Fujita
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nishii
authors.forename: Kiyohisa
authors.initials: K
authors.lastname: Kamimura
authors.forename: Shogo
authors.initials: S
authors.lastname: Kiyohara
authors.forename: Shigemi
authors.initials: S
authors.lastname: Futami
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Onitsuka
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Nagoshi
authors.forename: Shozo
authors.initials: S
authors.lastname: Tamura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Hideo
authors.initials: H
authors.lastname: Arita
mesh_terms: D000328:Adult; D000368:Aged; D002302:Cardiac Output; D003971:Diastole / Q000502:physiology; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000295:instrumentation / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D012986:Software Validation; D013318:Stroke Volume; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*; D016277:Ventricular Function, Left
chemical_list: D013794:Thallium Radioisotopes