Endocrine disruptors affect developmental programming of HOX gene expression.
HOX gene expression determines the differential developmental identity of the Müllerian duct. Diethylstilbestrol and several environmental xenoestrogens disrupt the development of the female reproductive tract by altering HOX gene expression, leading to structural and functional defects.
Taylor
Hugh S
HS
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA. hugh.taylor@yale.edu
D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D005836:Genitalia, Female / Q000002:abnormalities* / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans
D052244:Endocrine Disruptors; D018398:Homeodomain Proteins