title: Dynamics of infection and immunity in a dairy cattle population undergoing an eradication programme for Infectious Bovine Rhinotracheitis (IBR).
abstract: Several countries within the European Union (EU) have successfully eradicated Infectious Bovine Rhinotracheitis (IBR), while others (e.g. Germany) are making efforts to achieve IBR-free status. EU member states IBR eradication programmes must meet Community legislation requirements that ban breeding farms from purchasing positive animals, from using whole-virus IBR vaccines, and from inseminating cows with semen from positive bulls. A follow-up study from 2002 to 2005 was carried out in the province of Trento (Italy), where a compulsory programme for IBR eradication was started in 1998. IBR outbreaks (identified on the basis of seroconversion of sentinel animals) were concentrated in larger positive herds. A higher incidence was recorded between 2003 and 2004. An association between markedly high temperatures in the summer of 2003 and virus reactivation has been suggested but is yet to be confirmed. The practice of driving cattle to common alpine pastures for the summer season did not play a significant epidemiological role in IBR transmission. Premising that only seronegative animals are allowed to enter dairy farms, animal movement increases the infection risk to a moderate extent. The long-term persistence of IBR antibodies was more pronounced in animals positive for antibodies to the glycoprotein E (gE). Scattered seroconversions, occurring mostly in positive herds, require careful interpretation in order to avoid overestimating the incidence of the infection at herd level.
authors.affiliation: Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'Università 10, 35020 Legnaro, Italy. snardelli@izsvenezie.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Nardelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Farina
authors.forename: Rosaria
authors.initials: R
authors.lastname: Lucchini
authors.forename: Claudio
authors.initials: C
authors.lastname: Valorz
authors.forename: Angela
authors.initials: A
authors.lastname: Moresco
authors.forename: Riccardo
authors.initials: R
authors.lastname: Dal Zotto
authors.forename: Carlo
authors.initials: C
authors.lastname: Costanzi
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002417:Cattle; D003140:Communicable Disease Control / Q000379:methods; D016208:Databases, Factual; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology* / Q000302:isolation & purification; D007241:Infectious Bovine Rhinotracheitis / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D007558:Italy / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014764:Viral Proteins; C046998:bovine herpesvirus type-1 glycoproteins