title: Acremolides A-D, lipodepsipeptides from an Australian marine-derived fungus, Acremonium sp.
abstract: An Australian estuarine isolate of an Acremonium sp. (MST-MF588a) yielded the two known compounds 19- O-acetylchaetoglobosin D ( 1) and 19- O-acetylchaetoglobosin B ( 2), as the sole cytotoxic principles, along with the known aromatic metabolite RKB 3564S ( 3), and a novel family of lipodepsipeptides, acremolides A-D ( 4- 7). Structures were assigned to 4- 7 on the basis of detailed spectroscopic analysis and chemical derivatization and by application of a new C 3 Marfey's method for amino acid analysis.
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
authors.forename: Ranjala
authors.initials: R
authors.lastname: Ratnayake
authors.forename: Leith J
authors.initials: LJ
authors.lastname: Fremlin
authors.forename: Ernest
authors.initials: E
authors.lastname: Lacey
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Gill
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000818:Animals; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013648:Tasmania
chemical_list: C529253:19-O-acetylchaetoglobosin B; C529252:19-O-acetylchaetoglobosin D; D047630:Depsipeptides