title: Bioevaluation of 32P patch designed for the treatment of skin diseases.
abstract: OBJECTIVE
  The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases.
  
  
  METHODS
  The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied.
  
  
  RESULTS
  Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples.
  
  
  CONCLUSIONS
  The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.
authors.affiliation: Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina. jsalgueiro@ffyb.uba.ar
authors.forename: Maria Jimena
authors.initials: MJ
authors.lastname: Salgueiro
authors.forename: Hebe
authors.initials: H
authors.lastname: Duran
authors.forename: Monica
authors.initials: M
authors.lastname: Palmieri
authors.forename: Rosana
authors.initials: R
authors.lastname: Pirchio
authors.forename: Vanina
authors.initials: V
authors.lastname: Medina
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ughetti
authors.forename: Maximo
authors.initials: M
authors.lastname: Croci
authors.forename: Jorge
authors.initials: J
authors.lastname: Nicolini
authors.forename: Marcela
authors.initials: M
authors.lastname: Zubillaga
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D004195:Disease Models, Animal; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008657:Metabolic Clearance Rate; D051379:Mice; D010761:Phosphorus Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000532:radiotherapy*; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D010761:Phosphorus Radioisotopes