Helicobacter pylori interference with micronutrients and orally administered drugs: a new mechanism explaining its role in extragastric disorders.
There is an increasing evidence that Helicobacter pylori may interfere with gastrointestinal metabolism of micronutrients and drugs such as iron, cobalamin, thyroxine and levodopa, with relevant clinical effects. In this review we examine the strength of the causal association and the plausible pathophysiologic mechanisms underlying these adverse effects.
Pietroiusti
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Dipartimento di Biopatologia-Cattedra di Medicina del Lavoro, Viale Montpellier 1 - 00133 - Roma, Italy. pietroiu@uniroma2.it
Galante
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Magrini
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Bergamaschi
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D000284:Administration, Oral; D016480:Helicobacter pylori / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D008286:Malabsorption Syndromes; D018977:Micronutrients / Q000008:administration & dosage / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D014805:Vitamin B 12 / Q000378:metabolism
D018977:Micronutrients; D004364:Pharmaceutical Preparations; D014805:Vitamin B 12