[Pharmacovigilance update].
The observations of pharmacovigilance reported during 2007 reflect an increasing attention towards drug-induced augmentation of the incidence of common disorders. New substances are thus to be added to the list of risk factors susceptible to favour cardiovascular events (tegaserod, rosiglitazone, erythropoïetin, aprotinine) or psychiatric disorders (dopaminergic agonists, rimonabant). The evaluation of the security profile of new medicines remains challenging. Besides biological investigations of questionable relevance and clinical trial of inconstant efficiency towards safety outcomes, the role of pharmacovigilance notifications by practitioners remains of paramount importance.
Livio
F
F
Division de pharmacologie et toxicologie cliniques, CHUV, 1011 Lausanne. francoise.livio@chuv.ch
Buclin
T
T
Biollaz
J
J
D003863:Depression / Q000139:chemically induced; D064420:Drug-Related Side Effects and Adverse Reactions; D006331:Heart Diseases / Q000139:chemically induced; D006801:Humans; D009468:Neuromuscular Diseases / Q000139:chemically induced; D004364:Pharmaceutical Preparations / Q000008:administration & dosage
D004364:Pharmaceutical Preparations