title: [Constrictive pericarditis or restrictive cardiomyopathy? Echocardiographic tissue Doppler analysis].
abstract: OBJECTIVE
  Echocardiographic tissue Doppler imaging (TDI) has been proposed for differentiating between constrictive pericarditis (CP) and restrictive cardiomyopathy (RCM). The aim of this retrospective study was to analyse TDI in patients with severe diastolic dysfunction associated with proven constrictive pericarditis or restrictive cardiomyopathy.
  
  
  METHODS
  The cohort included 34 consecutive patients (24 men. 10 women; mean age 58 12 years), 20 of whom had proven CP (pericardectomy) and 14 had RCM due to amyloidosis (proven by biopsy). Tissue Doppler Imaging was performed online by pulsed-wave TDI at the lateral and septal mitral annulus in the four-chamber view. Filling pressures were measured invasively.
  
  
  RESULTS
  20 of the 34 patients (60%) were in NYHA class III. 19 of the 34 patients were in sinus rhythm (56 %) and 15 had atrial fibrillation. Left ventricular systolic function was normal in all patients with CP. Eight patients with RCM had normal, 3 patients near normal and 3 patients slightly impaired left ventricular contractile function (EF 50-55% and EF 40%, respectively). Respiratory variation of the transmitral inflow was increased in 10 of 12 patients with CP and sinus rhythm. TDI of the early diastolic velocity across the mitral annulus E} was significantly higher in patients with CP than in those with RCM at the septal and at the lateral mitral annulus (13.8 4.2 cm/s vs. 4.0 1.2 cm/s; p < 0.01 and 11.4 3.4 cm/s vs. 4.4 1.7 cm/s; p < 0.01, respectively). A cut-off value 8 cm/s for the diagnosis of RCM showed a sensitivity of 100% and a specificity of 90% (septal) and 80% (lateral), respectively. The E/E}ratio also was significantly different between both groups (septal: 11.2 8.8 vs. 25.1 8.7; p < 0.01).
  
  
  CONCLUSIONS
  TDI of the early diastolic velocity of the mitral annulus E} makes it possible to differentiate between constrictive pericarditis and restrictive cardiomyopathy and should be part of the echocardiographic work-up in clinical routine.
authors.affiliation: Medizinische Klinik II (Kardiologie u. Angiologie), Marienhospital Herne, Klinikum der Ruhr-Universität Bochum, Herne. thomas.butz@marienhospital-herne.de
authors.forename: T
authors.initials: T
authors.lastname: Butz
authors.forename: L
authors.initials: L
authors.lastname: Faber
authors.forename: C
authors.initials: C
authors.lastname: Piper
authors.forename: C
authors.initials: C
authors.lastname: Langer
authors.forename: T
authors.initials: T
authors.lastname: Kottmann
authors.forename: H K
authors.initials: HK
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Wiemer
authors.forename: R
authors.initials: R
authors.lastname: Körfer
authors.forename: D
authors.initials: D
authors.lastname: Horstkotte
mesh_terms: D000686:Amyloidosis / Q000150:complications; D001706:Biopsy; D001783:Blood Flow Velocity; D002313:Cardiomyopathy, Restrictive / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D015331:Cohort Studies; D003937:Diagnosis, Differential; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D010494:Pericarditis, Constrictive / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity