title: Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China.
abstract: The frequencies of human leukocyte antigen (HLA) alleles HLA-A, -B, and -DRB1 alleles and A-B-DRB1, A-B, and B-DRB1 haplotypes were studied in Jinuo and Wa populations in Southwest China using the polymerase chain reaction-Luminex (PCR-Luminex) typing method. A total of 12 A, 22 B, and 16 DRB1 alleles were found in the Jinuo population, and 10 A, 28 B, and 18 DRB1 alleles were found in the Wa population. The A*110101-B*1502-DRB1*120201 was the predominant haplotype in both the Jinuo and Wa populations; A*110101-B*1301-DRB1*120201 and A*24020101-B*1502-DRB1*120201 were common in the Jinuo population, whereas A*110101-B*1532-DRB1*1504 and A*110101-B*350101-DRB1*1404 were common in the Wa population. Phylogenetic tree and principal component analyses based on HLA-A, -B, and -DRB1 allele frequencies suggested that both the Jinuo and Wa populations belong to the Southeast Asian group, whereas Wa population is still maintaining its original genetic character and a great distance from other populations because of a founder effect and subsequent geographic isolation. A close relationship among Jinuo, Wa, Thai, and Vietnamese was also suggested.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.forename: Saeko
authors.initials: S
authors.lastname: Ogata
authors.forename: Jian Kun
authors.initials: JK
authors.lastname: Yu
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Keqin
authors.initials: K
authors.lastname: Lin
authors.forename: Xiao Qin
authors.initials: XQ
authors.lastname: Huang
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsushita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Horai
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Jia You
authors.initials: JY
authors.lastname: Chu
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
mesh_terms: D002681:China / Q000208:ethnology; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D010802:Phylogeny; D025341:Principal Component Analysis
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains