title: Autoimmune lymphoproliferative syndrome (ALPS): a rare cause of immune cytopenia.
abstract: Autoimmune Lymphoproliferative syndrome (ALPS) is an inherited disorder manifesting with autoimmune cytopenia, lymphadenopathy and splenomegaly. The differential diagnosis includes infections, autoimmune disorders or malignancies. The disease is characterized by accumulation of double negative (CD3+ CD4- CD8-) T cells (DNT) in the peripheral blood. We describe a case and review the literature.
authors.affiliation: Department of Hematology, Christian Medical College, Vellore, India.
authors.forename: M Joseph
authors.initials: MJ
authors.lastname: John
authors.forename: Reena
authors.initials: R
authors.lastname: Rajasekhar
authors.forename: Vikram
authors.initials: V
authors.lastname: Mathews
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D017252:CD3 Complex / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology*; D002648:Child; D015897:Comorbidity; D003937:Diagnosis, Differential; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications / Q000276:immunology*; D008231:Lymphopenia / Q000150:complications / Q000276:immunology*; D008297:Male; D013163:Splenomegaly / Q000150:complications / Q000276:immunology*; D013577:Syndrome
chemical_list: D001323:Autoantibodies; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens