Intracellular spatial control of fluorescent magnetic nanoparticles.
We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.
Gao
Jinhao
J
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Zhang
Wei
W
Huang
Pingbo
P
Zhang
Bei
B
Zhang
Xixiang
X
Xu
Bing
B
D019187:Cadmium Compounds / Q000737:chemistry; D002460:Cell Line; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry
D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D018036:Selenium Compounds; C058667:cadmium selenide; D052203:Ferrosoferric Oxide