title: Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia.
abstract: The study was undertaken with the aim to outline deletion patterns involving the long arm of chromosome 6, a common abnormality in lymphoproliferative disorders. Using a chromosome 6 specific tile path array, 60 samples from in total 49 cases with mantle cell lymphoma (MCL), de novo diffuse large B-cell lymphoma (DLBCL), transformed DLBCL as well as preceding follicular lymphoma (FL), and childhood acute lymphoblastic leukemia (ALL), were characterized. Twenty-six of the studied cases, representing all diagnoses, showed a 6q deletion among which 85% involved a 3 Mb region in 6q21. The minimal deleted interval in 6q21 encompasses the FOXO3A, PRDM1 and HACE1 candidate genes. The PRDM1 gene was found homozygously deleted in a case of DLBCL. Moreover, in two DLBCL cases, an overlapping homozygous deletion was identified in 6q23.3 - 24.1, encompassing the TNFAIP3 gene among others. Taken together, we refined the deletion pattern within the long arm of chromosome 6 in four different types of hematological malignances, suggesting the location of tumor suppressor genes involved in the tumor progression.
authors.affiliation: Medical Genetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Emma Flordal
authors.initials: EF
authors.lastname: Thelander
authors.forename: Koichi
authors.initials: K
authors.lastname: Ichimura
authors.forename: Martin
authors.initials: M
authors.lastname: Corcoran
authors.forename: Gisela
authors.initials: G
authors.lastname: Barbany
authors.forename: Ann
authors.initials: A
authors.lastname: Nordgren
authors.forename: Mats
authors.initials: M
authors.lastname: Heyman
authors.forename: Mattias
authors.initials: M
authors.lastname: Berglund
authors.forename: Andy
authors.initials: A
authors.lastname: Mungall
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
authors.forename: V Peter
authors.initials: VP
authors.lastname: Collins
authors.forename: Dan
authors.initials: D
authors.lastname: Grandér
authors.forename: Catharina
authors.initials: C
authors.lastname: Larsson
authors.forename: Svetlana
authors.initials: S
authors.lastname: Lagercrantz
mesh_terms: D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000235:genetics*; D008224:Lymphoma, Follicular; D016403:Lymphoma, Large B-Cell, Diffuse; D020522:Lymphoma, Mantle-Cell; D000074462:Positive Regulatory Domain I-Binding Factor 1; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1; C497506:HACE1 protein, human; D044767:Ubiquitin-Protein Ligases