The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors.
Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.
Han
Yefei
Y
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lai
Jun
J
Barditch-Crovo
Patricia
P
Gallant
Joel E
JE
Williams
Thomas M
TM
Siliciano
Robert F
RF
Blankson
Joel N
JN
D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D015236:HLA-C Antigens / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014766:Viremia / Q000235:genetics; D014779:Virus Replication / Q000235:genetics*
C080521:HCP5 long noncoding RNA, human; D015236:HLA-C Antigens; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated