In vivo measurements of ultrasound transmission through the human proximal femur.
Quantitative ultrasound (QUS) measurements can be used to estimate osteoporotic fracture risk. The commonly used variables are the speed of sound (SOS) and the frequency dependent sound attenuation (broadband ultrasound attenuation, [BUA]) of a wave propagating through the bone, preferably the calcaneus. The technology, so far, is less suitable for direct measurement in vivo at the spine or the femur for prediction of bone mineral density (BMD) or fracture risk at the main osteoporotic fracture sites. To improve the clinical performance of QUS, we built a device for direct QUS measurements at the human femur in vivo. In vivo images of ultrasound transmission at one of the main fracture sites, the proximal femur, could be acquired. The estimated precision of SOS measurements of 0.5% achieved at the femur is comparable with the precision of peripheral QUS devices.
Barkmann
Reinhard
R
Medizinische Physik, Diagnostische Radiologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany. barkmann@rad.uni-kiel.de
Laugier
Pascal
P
Moser
Urs
U
Dencks
Stefanie
S
Klausner
Michael
M
Padilla
Frédéric
F
Haiat
Guillaume
G
Heller
Martin
M
Glüer
Claus-C
CC
D015519:Bone Density; D005240:Feasibility Studies; D005269:Femur / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006620:Hip Fractures / Q000209:etiology; D006801:Humans; D010024:Osteoporosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018570:Risk Assessment; D014159:Transducers; D014463:Ultrasonography