Changes in regional cerebral blood flow after repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in treatment-resistant depression.
High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex is effective in treatment-resistant depression, although its mechanism is still not completely elucidated. To clarify the neuroanatomical alteration of function elicited by rTMS, single photon emission computed tomography (SPECT) with (99m)Tc-ECD was performed on 12 male inpatients with treatment-resistant unipolar depression before and after high-frequency rTMS of the left dorsolateral prefrontal cortex. These results suggest that the manifestation of the antidepressant effect of high-frequency rTMS is associated with changes in the neuroanatomical function of the left dorsolateral prefrontal cortex as well as of the limbic-paralimbic region, including the ipsilateral subgenual cingulate, and the basal ganglia.
Kito
Shinsuke
S
Department of Neuropsychiatry, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. kito@kk.iij4u.or.jp
Fujita
Kenichi
K
Koga
Yoshihiko
Y
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives / Q000378:metabolism; D003863:Depression / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000378:metabolism; D017397:Prefrontal Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D050781:Transcranial Magnetic Stimulation
D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine