title: Effects of Radix scutellariae and Rhizoma atractylodis on LPS-induced abortion and the uterine IL-10 contents in mice.
abstract: In the present study, lipopolysaccharide (LPS) was injected i.v. via the tail vein (0.1 microg per mouse) to induce abortion (embryo resorption) in Kunming mice. The interleukin 10 (IL-10) contents in the uterus were assayed by ELISA. The results revealed that the IL-10 level was significantly decreased in the LPS-induced abortion group of mice compared to the controls. Use of Pentoxifylline (PXF), or a combination of Radix scutellariae and Rhizoma atractylodis reversed the LPS effects: bringing down the fetal resorption rate, and increasing the IL-10 level significantly. The study indicates that the anti-abortive effects of PXF and the combination of Radix scutellariae and Rhizoma atractylodis are closely related to up-regulation of the Th2 cytokine IL-10 at the maternal fetal interface.
authors.affiliation: College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding City 071001, China. zhongxiuhui@263.net
authors.forename: Xiu-Hui
authors.initials: XH
authors.lastname: Zhong
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Shi
authors.forename: Ai-Tuan
authors.initials: AT
authors.lastname: Ma
authors.forename: Xin-Cheng
authors.initials: XC
authors.lastname: Gong
authors.forename: Xiang-He
authors.initials: XH
authors.lastname: Zhai
authors.forename: Tie
authors.initials: T
authors.lastname: Zhang
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Wang
mesh_terms: D000019:Abortifacient Agents / Q000633:toxicity*; D000028:Abortion, Induced / Q000379:methods / Q000706:statistics & numerical data; D000818:Animals; D029064:Araceae; D020964:Embryo Loss / Q000503:physiopathology; D005260:Female; D016753:Interleukin-10 / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D029626:Ranunculaceae; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
chemical_list: D000019:Abortifacient Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D016753:Interleukin-10