[Bitterness of the mixture of clarithromycin dry syrup and carbocisteine preparation--difference between brand name and generic drugs].
The purpose of this study was to assess the bitterness intensity and pH of the solutions of clarithromycin dry syrup (CAM-DS), carbocisteine preparation (CC), and the concomitant use of both drugs. We conducted 6 types of human gustatory sensation tests with 6 healthy male volunteers. As a result, there was almost no difference in the bitterness intensity of CAM-DS between the branded (the latest and former preparations) and the generic formulations. The bitterness intensity of CAM-DS (the latest and former preparations of the branded as well as the generic formulations) was almost equally enhanced by mixing it with either the branded CC-DS or the branded and the generic carbocisteine granule (CC-Gr). On this occasion, the enhancing the bitterness of the branded CAM-DS (latest and former preparation) was nearly avoided safely by dosage form's changing CC-DS or CC-Gr to the branded CC-Sy. However, unlike the branded CC-Sy, some generic CC-Sy failed to suppress the bitterness. Furthermore, it was proven that some generic CAM-DS were shown to exhibit bitterness when mixed with even branded CC-Sy. In conclusion, it should be noted that the extent of bitterness of the mixture of CAM-DS and CC highly varies among the generic formulations.
Matsuo
Ritsuko
R
Incorporated Foundation of Wadoukai Pharmacy, Tokyo, Japan.
Tanaka
Syouko
S
Kanou
Michiko
M
Isono
Kimiko
K
Tanaka
Yasuha
Y
Taura
Tomoko
T
Asada
Yuki
Y
Akamine
Yukiko
Y
Sawai
Hashimu
H
Kinosita
Masakazu
M
Sudou
Tomomi
T
Kunoki
Yoshiko
Y
Miki
Akiko
A
Hori
Satoko
S
Satoh
Hiroki
H
Ohtani
Hisakazu
H
Sawada
Yasufumi
Y
D000900:Anti-Bacterial Agents; D002233:Carbocysteine; D002626:Chemistry, Pharmaceutical; D017291:Clarithromycin; D004304:Dosage Forms; D004338:Drug Combinations; D004339:Drug Compounding; D016568:Drugs, Generic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D013649:Taste; D013652:Taste Threshold
D000900:Anti-Bacterial Agents; D004304:Dosage Forms; D004338:Drug Combinations; D016568:Drugs, Generic; D002233:Carbocysteine; D017291:Clarithromycin