Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer.
Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.
Bellahcène
Akeila
A
Metastasis Research Laboratory, University of Liege, Tour de Pathologie, -1, Bât. B23, Sart Tilman via 4000 Liège, Belgium.
Castronovo
Vincent
V
Ogbureke
Kalu U E
KU
Fisher
Larry W
LW
Fedarko
Neal S
NS
D000818:Animals; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic; D053495:Osteopontin / Q000096:biosynthesis; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D016023:Integrins; D008024:Ligands; D010750:Phosphoproteins; D053495:Osteopontin