title: Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has been applied with variable success to terminate the seizures of epilepsia partialis continua. The rationale for using this technique to suppress ongoing seizures is the capacity of rTMS to interrupt ongoing neuronal activity, and to produce a lasting decrease in cortical excitability with low-frequency (1 Hz) stimulation. We report a case of epilepsia partialis continua in a child with Rasmussen's encephalitis, in whom seizures were transiently suppressed by 1-Hz rTMS delivered in nine daily 30-minute sessions. In this case, total ictal time was significantly reduced during stimulation, but the daily baseline seizure rate remained unchanged. Notably, the detection and quantification of this short-lived improvement were enabled by recording EEG continuously during the rTMS session. Thus, we present this case to illustrate a potential utility of combined continuous EEG recording and rTMS in seizure treatment.
authors.affiliation: Division of Epilepsy and Clinical Neurophysiology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. alexander.rotenberg@childrens.harvard.edu
authors.forename: Alexander
authors.initials: A
authors.lastname: Rotenberg
authors.forename: Dewi
authors.initials: D
authors.lastname: Depositario-Cabacar
authors.forename: Erica Hyunji
authors.initials: EH
authors.lastname: Bae
authors.forename: Chellamani
authors.initials: C
authors.lastname: Harini
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pascual-Leone
authors.forename: Masanori
authors.initials: M
authors.lastname: Takeoka
mesh_terms: D000293:Adolescent; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications; D017036:Epilepsia Partialis Continua / Q000209:etiology / Q000628:therapy*; D019054:Evoked Potentials, Motor; D006801:Humans; D008297:Male; D050781:Transcranial Magnetic Stimulation / Q000379:methods*