Effect of short-term treatment with meloxicam and pimobendan on the renal function in healthy beagle dogs.
The aim of the study was to investigate the renal function in clinically normal dogs receiving meloxicam and pimobendan alone or in combination. Ten adult female beagle dogs were administered the treatment for 7 days in a randomized crossover trial (control/meloxicam/pimobendan/meloxicam and pimobendan). Renal function was assessed by blood urea, creatinine, sodium, potassium and chloride concentrations and by glomerular filtration rate, measured by means of renal scintigraphy [renal uptake of (99m)Tc-diethylenetriaminepentacetic acid (DTPA)] and plasma clearance of (99m)Tc-DTPA. As compared with the control group, renal uptake and plasma clearance of (99m)Tc-DTPA were not significantly modified after a 7-day period of treatment with meloxicam or pimobendan alone, or meloxicam and pimobendan in combination. Furthermore, urea, creatinine, sodium, potassium and chloride levels in the serum of the dogs during the 7-day period treatment were not significantly modified in relation to the treatments. It was therefore concluded that meloxicam and pimobendan alone or in combination did not alter renal function in healthy dogs.
Fusellier
M
M
Unité de Physiopathologie Animale et Pharmacologie Fonctionnelle, UPSP 5304, ENV Nantes, Nantes Cedex, France.
Desfontis
J-C
JC
Le Roux
A
A
Madec
S
S
Gautier
F
F
Thuleau
A
A
Gogny
M
M
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D018592:Cross-Over Studies; D004285:Dogs / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects*; D000077239:Meloxicam; D011724:Pyridazines / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate; D013843:Thiazines / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D013844:Thiazoles / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D014508:Urea / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011724:Pyridazines; D013843:Thiazines; D013844:Thiazoles; C041648:pimobendan; D014508:Urea; D003404:Creatinine; D000077239:Meloxicam; D016284:Technetium Tc 99m Pentetate