Muscle fatigue from losing your PHD.
Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2alpha- and PPARalpha-dependent fashion.
Dang
Chi V
CV
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. cvdang@jhmi.edu
Gao
Ping
P
D000222:Adaptation, Physiological; D000818:Animals; D001481:Basal Metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D017079:Exercise Tolerance; D006019:Glycolysis; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D007511:Ischemia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008931:Mitochondria, Muscle / Q000378:metabolism; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000098:blood supply / Q000201:enzymology*; D010101:Oxygen Consumption; D047495:PPAR gamma / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D047495:PPAR gamma; D011393:Procollagen-Proline Dioxygenase; D017382:Reactive Oxygen Species; D000099162:Endothelial PAS Domain-Containing Protein 1; C522721:PHD1 protein, mouse