B-Lymphoid and myeloid lineages biphenotypic acute leukemia with t(8;21)(q22;q22).
By analyzing the characteristics of morphology, immune phenotype, chromosome karyotype and clinical manifestations of six cases of B-lymphoid and myeloid lineages biphenotypic acute leukemia (BAL) with t(8;21)(q22;q22), a new subgroup of BAL was reported. Bone marrow eosinophilia (more than 5%) and pseudo-Chediak abnormalities were not found. Auer rods were also not identified in four of six cases. Immunophenotype revealed B-lymphoid and myeloid lineages positive, together with frequent and high expression of CD34 and CD33, and weak expression of HLA-DR. In addition to t(8;21) chromosomal translocation, deletion of Y chromosome and complex chromosome abnormalities were also found. Chemotherapy for myeloid and lymphoid leukemia simultaneously produced good response in the patients. BAL with t(8; 21)(q22; q22) might be a new subgroup of BAL, and it was suggested that the leukemia clone with t(8;21)(q22;q22) might have originated from an early phase of hematopoiesis, and AML1/ETO fusion gene might be related to differentiation of B lymphocyte.
He
Guangsheng
G
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Wu
Depei
D
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China. wudepei@suda.com.cn.
Sun
Aining
A
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Xue
Yongquan
Y
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Jin
Zhengming
Z
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Qiu
Huiying
H
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Tang
Xiaowen
X
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Miao
Miao
M
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Fu
Zhengzheng
Z
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Ma
Xiao
X
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Wang
Xiuli
X
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Chen
Zixin
Z
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Ruan
Changgeng
C
Jiangsu Insititute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D051925:CD79 Antigens / Q000378:metabolism; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D063268:Sialic Acid Binding Ig-like Lectin 3; D014178:Translocation, Genetic
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D051925:CD79 Antigens; C497881:CD79A protein, human; D063268:Sialic Acid Binding Ig-like Lectin 3