Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.
Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg.
Mohr
John F
JF
Division of Infectious Diseases, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 2.112, Houston, Texas 77030, USA. john.mohr@uth.tmc.edu
Ostrosky-Zeichner
Luis
L
Wainright
David J
DJ
Parks
Donald H
DH
Hollenbeck
Timothy C
TC
Ericsson
Charles D
CD
D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D019540:Area Under Curve; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D017576:Daptomycin / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D017576:Daptomycin