Cytotoxic hydrolyzable tannins from Balanophora japonica.
Four hydrolyzable tannins named balanophotannins D-G ( 1- 4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D ( 1) and F ( 3) were determined via the PGME method. Balanophotannin E ( 2) showed cytotoxicity to Hep G2 cancer cells with an IC 50 value of 4.22 microM.
Jiang
Zhi-Hong
ZH
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, People's Republic of China. zhjiang@hkbu.edu.hk
Wen
Xiao-Yun
XY
Tanaka
Takashi
T
Wu
Shao-Yu
SY
Liu
Zhongqiu
Z
Iwata
Hiromi
H
Hirose
Yoko
Y
Wu
Shuguang
S
Kouno
Isao
I
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031111:Balanophoraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000970:Antineoplastic Agents; D047348:Hydrolyzable Tannins; C529415:balanophotannin E