title: GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations.
abstract: BACKGROUND
  The most renowned biological ontology, Gene Ontology (GO) is widely used for annotations of genes and gene products of different organisms. However, there are shortcomings in the Resource Description Framework (RDF) data file provided by the GO consortium: 1) Lack of sufficient semantic relationships between pairs of terms coming from the three independent GO sub-ontologies, that limit the power to provide complex semantic queries and inference services based on it. 2) The term-centric view of GO annotation data and the fact that all information is stored in a single file. This makes attempts to retrieve GO annotations based on big volume datasets unmanageable. 3) No support of GOSlim.
  
  
  RESULTS
  We propose a RDF model, GORouter, which encodes heterogeneous original data in a uniform RDF format, creates additional ontology mappings between GO terms, and introduces a set of inference rulebases. Furthermore, we use the Oracle Network Data Model (NDM) as the native RDF data repository and the table function RDF_MATCH to seamlessly combine the result of RDF queries with traditional relational data. As a result, the scale of GORouter is minimized; information not directly involved in semantic inference is put into relational tables.
  
  
  CONCLUSIONS
  Our work demonstrates how to use multiple semantic web tools and techniques to provide a mixture of semantic query and inference solutions of GO and its associations. GORouter is licensed under Apache License Version 2.0, and is accessible via the website: http://www.scbit.org/gorouter/.
authors.affiliation: The Key Laboratory of Biomedical Photonics of the Ministry of Education, HUST, Wuhan 430074, China. xuqingwei@sina.com.cn
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Xu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Shi
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhang
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
authors.forename: Yixue
authors.initials: Y
authors.lastname: Li
mesh_terms: D000465:Algorithms; D003628:Database Management Systems; D030541:Databases, Genetic; D005796:Genes / Q000235:genetics*; D016247:Information Storage and Retrieval / Q000379:methods*; D008957:Models, Genetic; D009323:Natural Language Processing; D012984:Software