title: Autoimmune thrombocytopenia in non-Hodgkin's lymphomas.
abstract: Autoimmune thrombocytopenia is a common immunehematologic complication in non-Hodgkin's lymphomas and may complicate the treatment. We analyzed an original series from our institute as well as published cases of non-Hodgkin's lymphomas (excluding chronic lymphocytic leukemia) associated with autoimmune thrombocytopenia with regard to demographic factors, prevalence in non-Hodgkin's lymphoma subtypes and treatment outcome. The male/female ratio is 1.75. Half of the cases occurred prior to diagnosis of lymphoma. Chemotherapy is the best treatment in many non-Hodgkin's lymphomas patients with autoimmune thrombocytopenia compared with standard treatment of autoimmune thrombocytopenia. Splenectomy is effective in splenic marginal zone lymphoma. Autoimmune thrombocytopenia in patients with non-Hodgkin's lymphomas is potentially life-threatening and difficult to treat.
authors.affiliation: Department of Medicine I, Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria. alexander.hauswirth@meduniwien.ac.at
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Hauswirth
authors.forename: Cathrin
authors.initials: C
authors.lastname: Skrabs
authors.forename: Christian
authors.initials: C
authors.lastname: Schützinger
authors.forename: Markus
authors.initials: M
authors.lastname: Raderer
authors.forename: Andreas
authors.initials: A
authors.lastname: Chott
authors.forename: Peter
authors.initials: P
authors.lastname: Valent
authors.forename: Klaus
authors.initials: K
authors.lastname: Lechner
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jäger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology; D036102:Peripheral Blood Stem Cell Transplantation; D011183:Postoperative Complications / Q000453:epidemiology; D015995:Prevalence; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000453:epidemiology*; D013156:Splenectomy; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000453:epidemiology
chemical_list: D000970:Antineoplastic Agents