title: A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols.
abstract: A highly selective method to protect the 11 beta-OH position of steroid (1) has been developed. This is achieved via double silyl protection of the 11 beta, 17 alpha-diol, followed by selective desilylation of the 17 alpha-OH under basic conditions without the need for a fluoride source.
authors.affiliation: Pfizer Global R & D, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Glossop
authors.forename: Marcel
authors.initials: M
authors.lastname: Hoogenraad
authors.forename: Torren M
authors.initials: TM
authors.lastname: Peakman
authors.forename: Dannielle F
authors.initials: DF
authors.lastname: Roberts
mesh_terms: D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D013256:Steroids