Correlation between clinical features and degree of immunosuppression in HIV infected children.
We conducted this study to find out correlation of CD4% with clinical status in 102 HIV infected antiretroviral naive children. Mean age of presentation was 4.8 years. Perinatal transmission was the commonest mode of transmission (94%). Fever (53%), chronic diarrhea (36%), and cough (29%) were the commonest presenting symptoms. Protein energy malnutrition was seen in 56.7% of children. 33.3% children were asymptomatic, whereas 45.1% were in WHO clinical stages III and IV at the time of presentation. The most common opportunistic infection was tuberculosis. CD4% correlated significantly with the deterioration of the WHO clinical stages (P<0.01) and increasing grades of protein energy malnutrition (P< 0.05).
Agarwal
D
D
ART Center, Department of Medicine, Institute of Medical Science, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India. drdiptiagarwal@yahoo.co.in
Chakravarty
J
J
Sundar
S
S
Gupta
V
V
Bhatia
B D
BD
D000293:Adolescent; D015704:CD4 Antigens / Q000097:blood* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D011502:Protein-Energy Malnutrition / Q000453:epidemiology; D014944:World Health Organization
D015704:CD4 Antigens