An old paper revisited: "a mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load" by V.V. Dynnik, R. Heinrich and E.E. Sel'kov.
We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel'kov (1980a,b) describing: "A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load". We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the structure of the metabolic network in terms of elementary flux modes. We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles.
Nazaret
Christine
C
IMB, Université de Bordeaux 2, 146 Rue Léo-Saignat, F 33076 Bordeaux-cedex, France. nazaret@sm.u-bordeaux2.fr
Mazat
Jean-Pierre
JP
D000251:Adenosine Triphosphatases / Q000502:physiology; D000818:Animals; D001671:Biochemistry / Q000266:history*; D001693:Biological Transport, Active / Q000502:physiology; D050260:Carbohydrate Metabolism / Q000502:physiology*; D002952:Citric Acid Cycle / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D049673:History, 20th Century; D008954:Models, Biological
D000251:Adenosine Triphosphatases