title: Antigen detection from urine of Kala-azar cases by latex agglutination test.
abstract: A recently developed Latex agglutination method known as "KATEX" for detecting leishmanial antigen in urine of Kala-azar patients was evaluated on 97 Kala-azar cases and 35 controls in the department of Microbiology, Mymensingh Medical College during the period from March' 2004 to February' 2005. The method yielded sensitivity as 100% and 82.8% in 33 confirmed and 64 ICT positive cases respectively. Since 8.6% controls showed antigen positive results, so specificity of KATEX was calculated as 91.4%. KATEX methods for antigen detection in urine should be used as an early immuno-diagnostic test as it has yielded high sensitivity. But interpretation of a positive test must be made cautiously having correlation with clinical findings as because it becomes false positive in Kala-azar free person. Further elucidation of KATEX method including larger population from community giving particular emphasis on its prognostic use was strongly recommended.
authors.affiliation: Community Based Medical College, Bangladesh, Mymensingh, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: Ak
authors.initials: A
authors.lastname: Shamsuzzaman
authors.forename: Ak
authors.initials: A
authors.lastname: Musa
authors.forename: Ah
authors.initials: A
authors.lastname: Khan
authors.forename: Mc
authors.initials: M
authors.lastname: Mahmud
authors.forename: Ma
authors.initials: M
authors.lastname: Hossain
authors.forename: Aa
authors.initials: A
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000953:Antigens, Protozoan / Q000652:urine*; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007841:Latex Fixation Tests / Q000379:methods*; D007893:Leishmania donovani / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D000953:Antigens, Protozoan