title: Long-range 1H-1H NMR correlation: extending connectivities to remote bonds via an intermediate heterospin.
abstract: An out-and-stay 2D proton-proton NMR correlation experiment is proposed to detect long-range proton-proton connectivities up to six and seven bonds away. The magnetization flow pathway is based on a consecutive, dual-step J(CH)-transfer mechanism and it allows one to trace out (1)H-(1)H connectivities between protons belonging to different spin systems. This novel experimental scheme will be particularly useful in cases when carbon resonances overlap, providing connectivity information that could not be obtained in a HMBC experiment. The success of the experiment is demonstrated in the structural studies of a wide variety of chemical compounds.
authors.affiliation: Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, E-08193-Bellaterra, Barcelona, Spain. teodor.parella@uab.cat
authors.forename: Teodor
authors.initials: T
authors.lastname: Parella
authors.forename: Juan Félix
authors.initials: JF
authors.lastname: Espinosa
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry*; D003198:Computer Simulation; D006859:Hydrogen / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D011522:Protons; D013113:Spin Labels
chemical_list: D002250:Carbon Radioisotopes; D011522:Protons; D013113:Spin Labels; D006859:Hydrogen