title: Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma.
abstract: Lymphangiogenesis has recently been considered important for spread of malignant tumors. In the present study, lymphatic vessel density (LVD) including peritumoral LVD (P-LVD) and intratumoral LVD (I-LVD) was determined, respectively, by immunohistochemical staining with the antibody to LYVE-1 in 63 cases of early gastric carcinoma and 105 cases of advanced gastric carcinoma. The aim of the study is to investigate whether or not increased LVD could be a risk factor for nodal metastasis and survival. We conclude that increased P-LVD, but not I-LVD, could serve as an independent risk factor for nodal metastasis, recurrence and overall survival in gastric carcinoma.
authors.affiliation: Department of Pathology, School of Medicine, Shandong University, Jinan Wen Hua Xi Road 44, Jinan 250012, PR China. gaopeng@sdu.edu.cn
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Geng-Yin
authors.initials: GY
authors.lastname: Zhou
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Xiang
authors.forename: Shun-Li
authors.initials: SL
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Yan-Lin
authors.initials: YL
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis; D033921:Vesicular Transport Proteins / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C119248:LYVE1 protein, human; D033921:Vesicular Transport Proteins