Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission: a Go/Nogo study.
Major depressive disorder (MDD) can be characterized by a wide-ranging profile of cognitive deficits including attention, memory, and executive functions which is possibly due to reduced volumes and a hypometabolism of the anterior cingulate cortex, orbitofrontal, and dorsolateral prefrontal cortex. We examined 21 patients with MDD in partial remission and 21 age-, sex-, and education matched healthy controls using event-related potentials (ERPs). Participants performed a hybrid flanker Go/Nogo task while multichannel EEG was recorded. Two ERP components were of interest which repeatedly have been linked to response inhibition: the Nogo-N2 and the Nogo-P3 which can be observed in Nogo trials of a Go/Nogo task. MDD patients showed a specifically reduced Nogo-P3 while the Nogo-N2 and the P3b in Go trials were unaffected. These results provide further evidence of impaired response monitoring and control processes in patients with MDD.
Ruchsow
Martin
M
Department of Psychiatry, Christophsbad Göppingen, Germany. martin.ruchsow@christophsbad.de
Groen
Georg
G
Kiefer
Markus
M
Beschoner
Petra
P
Hermle
Leopold
L
Ebert
Dietrich
D
Falkenstein
Michael
M
D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003657:Decision Making / Q000502:physiology*; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests