title: Molecular-genetic systems of development: functional dynamics and molecular evolution.
abstract: This work for the first time compares results obtained with studies of parametric robustness of the Hh- and Dpp/BMP signal cascades responsible for morphogenesis and molecular evolution of the Hh- and Dpp/BMP cascade genes. There is a link between adaptive evolution of genes and those changes in kinetic parameters of the signal cascade models, which are critical for normal functioning of these cascades. Special attention is paid to events of the molecular evolution of the Hh- and Dpp/BMP cascade genes that matched with the emergence of the major taxonomic types and classes of Bilateria.
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. genkvg@bionet.nsc.ru
authors.forename: K V
authors.initials: KV
authors.lastname: Gunbin
authors.forename: V V
authors.initials: VV
authors.lastname: Suslov
authors.forename: N A
authors.initials: NA
authors.lastname: Kolchanov
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D016212:Transforming Growth Factor beta