Olanzapine plasma concentration in a newborn.
Little is known about the use of antipsychotics in pregnancy and the corresponding plasma levels in the newborn child. We report on a woman with schizophrenia treated with olanzapine during pregnancy. Plasma levels of olanzapine were assessed both from the mother and from umbilical cord. The plasma level of the newborn (11 ng/mL) was about one third compared to the mother (range 25-34 ng/mL).The development of the fetus, delivery and the development of the child during the first six months were normal.
Aichhorn
W
W
Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria. w.aichhorn@salk.at
Yazdi
K
K
Kralovec
K
K
Steiner
H
H
Whitworth
S
S
Stuppaeck
C
C
D000328:Adult; D014150:Antipsychotic Agents / Q000097:blood*; D001569:Benzodiazepines / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D000077152:Olanzapine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine