title: Trauma-induced central diabetes insipidus in a cat.
abstract: A 1-year-old neutered male domestic shorthair cat presented with a 4-week history of polydipsia that began immediately after an 8 m fall. Trauma-induced central diabetes insipidus was suspected on the basis of the identification of hyposthenuria, normal haematology and serum biochemistry profile and unremarkable abdominal ultrasound examination. Failure to concentrate urine with water deprivation followed by production of hypersthenuric urine with administration of the synthetic antidiuretic hormone, Damino-8-D-arginine vasopressin (DDAVP), confirmed the diagnosis of central diabetes insipidus. Treatment via conjunctival administration of DDAVP failed to attenuate the polydipsia, however, resolution of polydipsia was achieved with subcutaneous administration of DDAVP and the cat remains eudipsic with twice daily subcutaneous DDAVP administration 17 months after diagnosis.
authors.affiliation: Veterinary Teaching Hospital, University of Queensland, St Lucia QLD 4072, Australia. f.campbell@uq.edu.au
authors.forename: F E
authors.initials: FE
authors.lastname: Campbell
authors.forename: B
authors.initials: B
authors.lastname: Bredhauer
mesh_terms: D000058:Accidental Falls; D000818:Animals; D050034:Antidiuretic Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy / Q000209:etiology*; D002415:Cats; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin