title: Crystallization and preliminary x-ray analysis of anti-obesity peptide hormone oxyntomodulin.
abstract: Oxyntomodulin is a proglucagon-derived gut hormone that reduces food intake and body weight, thus represents a potential therapy for obesity. We synthesized and crystallized oxyntomodulin. The crystal diffracts x-ray to 2.4 A resolution and belongs to space group P2(1)3 with unit-cell parameters a=b=c= 48.44 A, alpha=beta=gamma=90 degrees . Preliminary analysis indicates a trimer packing in one asymmetric unit.
authors.affiliation: Department of Chemistry and Biochemistry Program, Indiana University, Bloomington, Indiana 47405, USA.
authors.forename: Pengyun
authors.initials: P
authors.lastname: Li
authors.forename: Tanya
authors.initials: T
authors.lastname: Rogers
authors.forename: David
authors.initials: D
authors.lastname: Smiley
authors.forename: Richard D
authors.initials: RD
authors.lastname: Dimarchi
authors.forename: Faming
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry*; D001835:Body Weight; D003460:Crystallization; D053772:Oxyntomodulin / Q000138:chemical synthesis / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D019440:Anti-Obesity Agents; D053772:Oxyntomodulin