title: High prevalence of diabetes and cardiovascular risk factors associated with urbanization in India.
abstract: OBJECTIVE
  To compare prevalence of diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and cardiovascular risk factors between a city, a town, and periurban villages (PUVs) in southern India and to look for temporal changes in the city and PUVs.
  
  
  METHODS
  Subjects aged >/=20 years were studied in Tamilnadu, India, in Chennai (city, n = 2,192; 1,053 men and 1,138 women), Kanchipuram (town, n = 2,290; 988 men and 1,302 women), and Panruti (PUVs, n = 2,584; 1,280 men and 1,304 women) in 2006. Demographic, socioeconomic, and anthropometric details; blood pressure; physical activity; diet habits; and lipids were studied. Risk associations with diabetes were analyzed using multiple logistic regression analyses. Present and previous data in the city and the PUVs were compared.
  
  
  RESULTS
  Mean BMI, waist circumference, and family history of diabetes were significantly lower in the PUVs. The PUVs had a lower prevalence of diabetes (9.2 [95% CI 8.0-10.5], P < 0.0001) than the city (18.6 [16.6-20.5]) and town (16.4 [14.1-18.6]). Approximately 40% of subjects were newly diagnosed. Prevalence of impaired glucose tolerance (IGT) was higher (P < 0.0001) in the city (7.4 [6.2-8.5]) than in the town (4.3 [3.3-5.3]) and the PUVs (5.5 [4.6-6.5]). Prevalence of IFG was generally low. Age, family history, and waist circumference were significantly associated with diabetes, while physical activity was not. Overweight, elevated waist circumference, hypertension, and dyslipidemia were more prevalent in the city.
  
  
  CONCLUSIONS
  In the city, diabetes increased from 13.9 to 18.6% in 6 years and IGT decreased significantly. The town and city had similar prevalences; the PUVs had lower diabetes prevalence, but prevalence had increased compared with that in a previous survey. Cardiometabolic abnormalities were more prevalent in urban populations.
authors.affiliation: India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals, Egmore, Chennai, India. ramachandran@vsnl.com
authors.forename: Ambady
authors.initials: A
authors.lastname: Ramachandran
authors.forename: Simon
authors.initials: S
authors.lastname: Mary
authors.forename: Annasami
authors.initials: A
authors.lastname: Yamuna
authors.forename: Narayanasamy
authors.initials: N
authors.lastname: Murugesan
authors.forename: Chamukuttan
authors.initials: C
authors.lastname: Snehalatha
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D004522:Educational Status; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D007194:India / Q000453:epidemiology; D008019:Life Style; D008297:Male; D009790:Occupations; D015995:Prevalence; D012307:Risk Factors; D014505:Urban Population / Q000706:statistics & numerical data*
chemical_list: D001786:Blood Glucose