title: Proinflammatory and oxidative stress markers in patients with periodontal disease.
abstract: OBJECTIVE
  To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis.
  
  
  METHODS
  Eighteen subjects were divided in two groups: experimental (age 52.9+/-5.0) and control (age 51.1+/-9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test and P<.05.
  
  
  RESULTS
  Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05).
  
  
  CONCLUSIONS
  The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
authors.affiliation: Department of Nutrition, Federal University of Santa Catarina, 88040-970 Florianópolis, SC, Brazil.
authors.forename: Ivan
authors.initials: I
authors.lastname: Borges
authors.forename: Emília Addison Machado
authors.initials: EA
authors.lastname: Moreira
authors.forename: Danilo Wilhem
authors.initials: DW
authors.lastname: Filho
authors.forename: Tiago Bittencourt
authors.initials: TB
authors.lastname: de Oliveira
authors.forename: Marcelo Barreto Spirelle
authors.initials: MB
authors.lastname: da Silva
authors.forename: Tânia Silvia
authors.initials: TS
authors.lastname: Fröde
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005881:Gingiva / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010510:Periodontal Diseases / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D009195:Peroxidase; D005978:Glutathione