title: Intranasal corticosteroids in the treatment of allergic rhinitis.
abstract: Intranasal corticosteroids (INCSs) have been established as the first-line treatment of moderate to severe allergic rhinitis (AR). Compared with other monotherapies, INCSs are most effective at controlling underlying allergic inflammation and providing symptom relief. Although currently available INCSs show comparable efficacy in controlling nasal symptoms of AR, onset and duration of action are thought to be somewhat variable among the INCSs. The low frequency of side effects suggests that, at recommended doses, INCSs are safe for the treatment of AR. However, concerns remain regarding the long-term systemic side effects associated with INCS therapy. Recent clinical studies have indicated that ciclesonide provides effective relief from nasal symptoms of AR and may have a rapid onset of action. Moreover, the results of two clinical trials, including a 52-week study, have suggested that intranasal ciclesonide does not cause cortisol suppression. Furthermore, intranasal ciclesonide does not have an additive effect on the hypothalamic-pituitary-adrenal-axis function when administered in combination with inhaled corticosteroids (ICSs), indicating that intranasal ciclesonide can be used in combination with an ICS in patients with asthma and comorbid AR. Therefore, intranasal ciclesonide appears to provide an additional treatment option for patients with AR.
authors.affiliation: Sylvana Research Associates, 7711 Louis Pasteur Drive, Suite 407, San Antonio, TX 78229, USA. phratner@swbell.net
authors.forename: Paul H
authors.initials: PH
authors.lastname: Ratner
authors.forename: Stuart
authors.initials: S
authors.lastname: Stoloff
authors.forename: Eli O
authors.initials: EO
authors.lastname: Meltzer
authors.forename: James A
authors.initials: JA
authors.lastname: Hadley
mesh_terms: D000280:Administration, Inhalation; D000281:Administration, Intranasal; D018926:Anti-Allergic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000150:complications / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D006889:Hydroxycorticosteroids / Q000008:administration & dosage*; D011282:Pregnenediones / Q000008:administration & dosage*; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000188:drug therapy*
chemical_list: D018926:Anti-Allergic Agents; D006889:Hydroxycorticosteroids; D011282:Pregnenediones; C120481:ciclesonide