Interactions of polyphenols with the P450 system: possible implications on human therapeutics.
Polyphenols are a family of natural compounds with many biological properties. This review focuses on their potential interaction on the cytochrome P450 system. Effects of phenolic acids, anthocyanins, stilbenes, catechins and other flavonoids on the drug metabolising function are revised. Their daily intake and presence in herbal medicines justify the study of potential drug-interaction to prevent undesirable clinical consequences.
Rodeiro
I
I
Laboratorio de Farmacología, Departamento de Investigaciones Biomédicas, Centro de Química Farmacéutica, Ciudad de la Habana, Cuba.
Donato
M T
MT
Lahoz
A
A
Garrido
G
G
Delgado
R
R
Gómez-Lechón
M J
MJ
D001682:Biological Availability; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D029001:Herbal Medicine; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry; D059808:Polyphenols
D065607:Cytochrome P-450 Enzyme Inhibitors; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D003577:Cytochrome P-450 Enzyme System