Type I interferon response to cytomegalovirus infection: the kick-start.
Host responses to cytomegalovirus infection include initial early production of alpha and beta interferons, also called type I interferons, which are elicited directly by viral products via Toll-like receptors. New data indicate that, preceding these events, an earlier critical type I interferon elicited in primary infected stromal cells via the lymphotoxin beta receptor system and mediated by B cells is necessary to kick-start an efficient antiviral response.
Fodil-Cornu
Nassima
N
Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada.
Vidal
Silvia M
SM
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology*; D053361:Lymphotoxin alpha1, beta2 Heterotrimer / Q000378:metabolism; D053259:Lymphotoxin beta Receptor / Q000378:metabolism; D051379:Mice; D018146:Muromegalovirus / Q000276:immunology*; D017154:Stromal Cells / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
D007370:Interferon Type I; D053361:Lymphotoxin alpha1, beta2 Heterotrimer; D053259:Lymphotoxin beta Receptor; D051193:Toll-Like Receptors