title: Gold-catalyzed double migration-benzannulation cascade toward naphthalenes.
abstract: A novel gold(I)-catalyzed cycloisomerization of propargylic esters leading to unsymmetrically substituted naphthalenes has been developed. This cascade reaction involves an unprecedented tandem sequence of 1,3- and 1,2-migration of two different migrating groups. It is believed that this transformation likely proceeds via the formation of 1,3-diene intermediate or its precursor, which upon cyclization and aromatization steps transforms into the naphthalene core.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Dudnik
authors.forename: Todd
authors.initials: T
authors.lastname: Schwier
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D009281:Naphthalenes; D006046:Gold