title: Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi.
abstract: Bacterial quorum sensing plays a very important role in the regulation of biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe for the first time the discovery of several boronic acids as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi.
authors.affiliation: Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA.
authors.forename: Nanting
authors.initials: N
authors.lastname: Ni
authors.forename: Han-Ting
authors.initials: HT
authors.lastname: Chou
authors.forename: Junfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
authors.forename: Chung-Dar
authors.initials: CD
authors.lastname: Lu
authors.forename: Phang C
authors.initials: PC
authors.lastname: Tai
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D001897:Boronic Acids / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D053038:Quorum Sensing / Q000187:drug effects / Q000502:physiology*; D014733:Vibrio / Q000187:drug effects / Q000502:physiology*
chemical_list: D001897:Boronic Acids