title: Factors associated with early failure of infrainguinal lower extremity arterial bypass.
abstract: OBJECTIVE
  We analyzed the Veterans Affairs (VA) National Surgical Quality Improvement Program (NSQIP), a large clinical database, to investigate which factors, other than technical, were associated with a higher incidence of early graft failure in infrainguinal bypass.
  
  
  METHODS
  Data are prospectively collected in NSQIP from 123 participating VA Medical Centers. All patients from 1995 to 2003 in the NSQIP database who underwent infrainguinal arterial bypass were identified by Current Procedural Terminology (CPT) codes (CPT is a registered trademark of the American Medical Association, Chicago, Ill, Copyright 2007). Data for 30-day graft failure were evaluated by univariate analysis, and multivariate logistic regression was used to control for possible confounders.
  
  
  RESULTS
  The NSQIP database identified 14,788 patients who underwent infrainguinal lower extremity arterial bypasses during the study period, and 723 acute graft failures (4.9%) occurred. On multivariate analysis, compared with patients aged >70 years, patient ages of <50 and 51 to 60 years were significantly associated with early graft failure (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.6-3.0; P < .001; OR, 1.4; 95% CI, 1.2-1.6, P < .001; respectively); age range of 61 to 70 years was not significantly associated with early graft failure. African American race was also associated with early graft failure, and diabetes mellitus had a negative association with early graft failure (OR, 1.4; 95% CI, 1.3-1.5; P < .001; OR, 0.72; 95% CI, 0.58-0.89; P = .002; respectively). Although smoking was a significant factor for acute graft failure on univariate analysis, it was not significant on multivariate analysis. Multivariate analysis of the type of procedure performed revealed that femoral to popliteal bypass with vein or prosthetic graft was associated with better early graft patency than any of the tibial vessel bypass procedures except for popliteal to tibial bypass with autogenous vein.
  
  
  CONCLUSIONS
  These data suggest that factors other than technique have an effect on the 30-day graft failure rates of infrainguinal bypasses. These results help the vascular surgeon to predict more accurately early bypass failure rates while planning the procedure and counseling patients about its prognosis.
authors.affiliation: Veterans Affairs Medical Center, Washington Hospital Center, Georgetown University Hospital, Washington, DC, USA.
authors.forename: Niten
authors.initials: N
authors.lastname: Singh
authors.forename: Anton N
authors.initials: AN
authors.lastname: Sidawy
authors.forename: Kent J
authors.initials: KJ
authors.lastname: DeZee
authors.forename: Richard F
authors.initials: RF
authors.lastname: Neville
authors.forename: Cameron
authors.initials: C
authors.lastname: Akbari
authors.forename: William
authors.initials: W
authors.lastname: Henderson
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data; D000367:Age Factors; D000368:Aged; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology; D006400:Hematocrit; D006787:Hospitals, Veterans; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011150:Popliteal Artery / Q000503:physiopathology / Q000601:surgery; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016909:Tibial Arteries / Q000503:physiopathology; D013997:Time Factors; D017211:Treatment Failure; D014481:United States / Q000453:epidemiology; D014654:Vascular Patency; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D014680:Veins / Q000637:transplantation*