Pharmacological agents and impairment of fracture healing: what is the evidence?
Bone healing is an extremely complex process which depends on the coordinated action of several cell lineages on a cascade of biological events, and has always been a major medical concern. The use of several drugs such as corticosteroids, chemotherapeutic agents, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, anticoagulants and drugs which reduce osteoclastic activity have been shown to affect bone healing. This review article presents our current understanding on this topic, focusing on data illustrating the effect of these drugs on fracture healing and bone regeneration.
Pountos
Ippokratis
I
Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, UK.
Georgouli
Theodora
T
Blokhuis
Taco J
TJ
Pape
Hans Chistoph
HC
Giannoudis
Peter V
PV
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology; D000925:Anticoagulants / Q000009:adverse effects / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D002146:Bony Callus / Q000187:drug effects*; D004164:Diphosphonates / Q000009:adverse effects / Q000494:pharmacology; D004195:Disease Models, Animal; D019317:Evidence-Based Medicine; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D004164:Diphosphonates