Apolipoprotein E knockout models.
Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.
Kolovou
Genovefa
G
Onassis Cardiac Surgery Center, 356 Sygrou Ave 176 74 Athens, Greece. genovefa@kolovou.com
Anagnostopoulou
Katherine
K
Mikhailidis
Dimitri P
DP
Cokkinos
Dennis V
DV
D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000628:therapy*; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D011485:Protein Binding / Q000235:genetics
D001057:Apolipoproteins E