title: Placental growth factor (PlGF) is a surrogate marker in preeclamptic hypertension.
abstract: OBJECTIVE
  To evaluate plasma levels of angiogenic factors and their association with preeclampsia.
  
  
  METHODS
  Twenty-three women with preeclampsia and nine normotensive pregnant women from the Maternity of Hospital das Clínicas of Belo Horizonte/MG-Brazil were assessed by National High Blood Pressure Education Program Working Group Creteria (NHBPEPWG). The plasma levels of vascular endothelial growth factor (VEGF) and Placental growth factor (PlGF) were determined by ELISA assay.
  
  
  RESULTS
  Plasma concentration of PlGF was 12-fold lower in preeclampsia versus non preeclampsia pregnancies. An inverse correlation was observed between PlGF plasma levels and mean arterial pressure (MAP); a decrease in 1pg/mL of PlGF resulted in 6.18 mm Hg increase in MAP.
  
  
  CONCLUSIONS
  These results indicate that PlGF is related to MAP in pregnant women.
authors.affiliation: Fetal Medicine Center, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Patrícia Gonçalves
authors.initials: PG
authors.lastname: Teixeira
authors.forename: Antônio Carlos Vieira
authors.initials: AC
authors.lastname: Cabral
authors.forename: Silvia Passos
authors.initials: SP
authors.lastname: Andrade
authors.forename: Zilma Silveira Nogueira
authors.initials: ZS
authors.lastname: Reis
authors.forename: Lívia Pieroni Barroso
authors.initials: LP
authors.lastname: da Cruz
authors.forename: Jacqueline Braga
authors.initials: JB
authors.lastname: Pereira
authors.forename: Breno Oliveira de Barcelos
authors.initials: BO
authors.lastname: Martins
authors.forename: Cezar Alencar de Lima
authors.initials: CA
authors.lastname: Rezende
mesh_terms: D000328:Adult; D015415:Biomarkers; D001938:Brazil; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor