[Optimal extraction of Dingxiang jiangqi granules].
OBJECTIVE
To screen and optimize the extraction of Dingxiangjiangqi granules.


METHODS
The extraction route was screened by using pharmacodynamic experiment and the extraction conditions were optimized by orthogonal design and taking extract yield, content of naringin and tetrahydropalmatine as indexes.


RESULTS
The pharmacodynamic result showed that aqueous extract had the best effect to cure the esophagitis of rats and the optimized extraction technique was adding 12 times water, extracting 0. 5 hour for 3 times.


CONCLUSIONS
The optimum extraction was simple, reasonable, stable and useful for further development.
Zhang
Li-Hong
LH
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China.
Fu
Yan
Y
Zhang
Zhi-Rong
ZR
Wang
Jian-Xin
JX
Ma
Shu-Ying
SY
Zhu
Sheng-Liang
SL
D000818:Animals; D001600:Berberine Alkaloids / Q000032:analysis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004942:Esophagitis, Peptic / Q000188:drug therapy / Q000473:pathology; D004947:Esophagus / Q000187:drug effects / Q000473:pathology; D044950:Flavanones / Q000032:analysis; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D027842:Syzygium / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
D001600:Berberine Alkaloids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D044950:Flavanones; C014215:tetrahydropalmatine; C005274:naringin