title: Analytical comparison of different parts of Radix Angelicae Sinensis by gas chromatography coupled with mass spectrometry.
abstract: The three parts of Radix Angelicae Sinensis (Danggui) were reported to have different therapeutic effects. In order to investigate their chemical compositions of different parts of Danggui, gas chromatography-mass spectrometry (GC-MS) combined with chemometrics data analysis was applied to provide a more detailed study. Subwindow factor analysis (SFA) and a modified augmented evolving window orthogonal projection (AEWOP) method were used to resolve the batch GC-MS data sets from the Danggui samples. Then, t-test, Wilcoxon rank sum test, and principal component analysis (PCA) were applied to carry out the comparison job. The results indicate which components are found to have significant differences among the three parts. These findings may be helpful for further research of the pharmacological activities of Danggui.
authors.affiliation: State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Chemometrics and Herbal Medicines Laboratory, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Shui-Yin
authors.initials: SY
authors.lastname: Wei
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Xu
authors.forename: Daniel Kam-Wah
authors.initials: DK
authors.lastname: Mok
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.forename: Tsui-Yan
authors.initials: TY
authors.lastname: Lau
authors.forename: Foo-Tim
authors.initials: FT
authors.lastname: Chau
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D025341:Principal Component Analysis
chemical_list: D010936:Plant Extracts