Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia.
Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia. Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies.
Suzuki
Hiroshi I
HI
Asai
Takashi
T
Tamaki
Zenshiro
Z
Hangaishi
Akira
A
Chiba
Shigeru
S
Kurokawa
Mineo
M
D000368:Aged; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000503:physiopathology; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D005077:Exanthema Subitum / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006410:Hematopoiesis; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D015614:Histiocytosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage / Q000009:adverse effects; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017254:Leukemic Infiltration / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014775:Virus Activation / Q000187:drug effects*
D000890:Anti-Infective Agents; D000914:Antibodies, Viral; D003561:Cytarabine; D000493:Allopurinol; D015255:Idarubicin