Crystallization and preliminary x-ray analysis of anti-obesity peptide hormone oxyntomodulin.
Oxyntomodulin is a proglucagon-derived gut hormone that reduces food intake and body weight, thus represents a potential therapy for obesity. We synthesized and crystallized oxyntomodulin. The crystal diffracts x-ray to 2.4 A resolution and belongs to space group P2(1)3 with unit-cell parameters a=b=c= 48.44 A, alpha=beta=gamma=90 degrees . Preliminary analysis indicates a trimer packing in one asymmetric unit.
Li
Pengyun
P
Department of Chemistry and Biochemistry Program, Indiana University, Bloomington, Indiana 47405, USA.
Rogers
Tanya
T
Smiley
David
D
Dimarchi
Richard D
RD
Zhang
Faming
F
D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry*; D001835:Body Weight; D003460:Crystallization; D053772:Oxyntomodulin / Q000138:chemical synthesis / Q000737:chemistry*; D014961:X-Ray Diffraction
D019440:Anti-Obesity Agents; D053772:Oxyntomodulin