Synthesis of novel C6-phosphonated purine nucleosides under microwave irradiation by SNAr-Arbuzov reaction.
Novel C6-phosphonated purine nucleosides were obtained in good to excellent isolated yields by the simple and catalyst-free SNAr-Arbuzov reaction of trialkyl phosphite with 6-choloropurine nucleosides, including a series of nonsugar carbon nucleosides. Shorter reaction times were needed, and substantially higher yields were obtained under microwave irradiation conditions compared with conventional heating conditions.
Qu
Gui-Rong
GR
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, Henan, P R China. ghm@henannu.edu.cn
Xia
Ran
R
Yang
Xi-Ning
XN
Li
Jian-Guo
JG
Wang
Dong-Chao
DC
Guo
Hai-Ming
HM
D013058:Mass Spectrometry; D008872:Microwaves; D063065:Organophosphonates / Q000138:chemical synthesis*; D011684:Purine Nucleosides / Q000138:chemical synthesis*
D063065:Organophosphonates; D011684:Purine Nucleosides