Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.
A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.
Hindi
Khadijah M
KM
Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
Siciliano
Tammy J
TJ
Durmus
Semih
S
Panzner
Matthew J
MJ
Medvetz
Doug A
DA
Reddy
D Venkat
DV
Hogue
Lisa A
LA
Hovis
Christine E
CE
Hilliard
Julia K
JK
Mallet
Rebekah J
RJ
Tessier
Claire A
CA
Cannon
Carolyn L
CL
Youngs
Wiley J
WJ
D000085:Acetates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019117:Burkholderia / Q000187:drug effects* / Q000254:growth & development; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004583:Electrons; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D006571:Heterocyclic Compounds / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008745:Methylation; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D018030:Silver Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
D000085:Acetates; D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D018030:Silver Compounds; D014867:Water; C103100:silver acetate; C030011:carbene; D008697:Methane