title: High-resolution, hand-held camera for sentinel-node detection.
abstract: BACKGROUND
  The imaging probe (IP) is a high-resolution (HR), 1-in(2) field-of-view hand-held gamma camera. We used it to detect breast cancer sentinel node (SN).
  
  
  METHODS
  We divided 120 T1 breast cancer patients, who underwent Anger camera lymphoscintigraphy (ACL), in two subgroups of 60 patients who were age, body mass index, and cancer size matched: subgroup A (SA) and B (SB). SN was detected with a common gamma probe (GP) in SA, with IP plus GP in SB.
  
  
  RESULTS
  Surgeons removed radioactive nodes without exceeding four nodes. Eighty-two (82) SNs were taken off in SA and 105 in SB (p<0.01). Of SA, 22 of 60 patients and 36 of 60 patients of SB showed more than 1 node, and 3 of them showed 3 nodes and 1 showed 4 nodes. Thirteen (13) patients resulted N(+) (21.6%) in SA. Ten (10) patients of SA showed an invasion on the hottest nodes and 3 on the second nodes. In the SB, 18 patients (25%) showed invasion. Sixteen (16) invasions were on hot, 4 on second, and 1 on the third node. Withdrawal time of SN was 11.25+/-4.7 minutes for SA and 7.4+/-2.8 minutes for SB (p<0.025).
  
  
  CONCLUSIONS
  SN biopsy with IP is fast and discovers more SNs and more invasions than ACL.
authors.affiliation: Department of Radiological Sciences, La Sapienza University, Rome, Italy. francesco.scopinaro@uniroma1.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Scopinaro
authors.forename: Anna
authors.initials: A
authors.lastname: Tofani
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: di Santo
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Pietro
authors.forename: Augusto
authors.initials: A
authors.lastname: Lombardi
authors.forename: Marzia
authors.initials: M
authors.lastname: Lo Russo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Soluri
authors.forename: Roberto
authors.initials: R
authors.lastname: Massari
authors.forename: Carlo
authors.initials: C
authors.lastname: Trotta
authors.forename: Claudio
authors.initials: C
authors.lastname: Amanti
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000556:secondary; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid