title: Edible safety requirements and assessment standards for agricultural genetically modified organisms.
abstract: This paper describes the background, principles, concepts and methods of framing the technical regulation for edible safety requirement and assessment of agricultural genetically modified organisms (agri-GMOs) for Shenzhen Special Economic Zone in the People's Republic of China. It provides a set of systematic criteria for edible safety requirements and the assessment process for agri-GMOs. First, focusing on the degree of risk and impact of different agri-GMOs, we developed hazard grades for toxicity, allergenicity, anti-nutrition effects, and unintended effects and standards for the impact type of genetic manipulation. Second, for assessing edible safety, we developed indexes and standards for different hazard grades of recipient organisms, for the influence of types of genetic manipulation and hazard grades of agri-GMOs. To evaluate the applicability of these criteria and their congruency with other safety assessment systems for GMOs applied by related organizations all over the world, we selected some agri-GMOs (soybean, maize, potato, capsicum and yeast) as cases to put through our new assessment system, and compared our results with the previous assessments. It turned out that the result of each of the cases was congruent with the original assessment.
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China. szdpj2002@163.com
authors.forename: Pingjian
authors.initials: P
authors.lastname: Deng
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhou
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Zhong
authors.initials: Z
authors.lastname: Du
authors.forename: Hongli
authors.initials: H
authors.lastname: Hou
authors.forename: Dongyan
authors.initials: D
authors.lastname: Yang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Tan
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Wu
authors.forename: Jinzhou
authors.initials: J
authors.lastname: Zhang
authors.forename: Yongcun
authors.initials: Y
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Guihua
authors.initials: G
authors.lastname: Liu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Shisong
authors.initials: S
authors.lastname: Fang
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D002681:China; D005502:Food / Q000009:adverse effects* / Q000592:standards*; D030841:Food, Genetically Modified / Q000009:adverse effects* / Q000592:standards*; D006801:Humans; D030821:Plants, Genetically Modified / Q000009:adverse effects / Q000737:chemistry; D015203:Reproducibility of Results; D018675:Toxicity Tests