Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma.
Lymphangiogenesis has recently been considered important for spread of malignant tumors. In the present study, lymphatic vessel density (LVD) including peritumoral LVD (P-LVD) and intratumoral LVD (I-LVD) was determined, respectively, by immunohistochemical staining with the antibody to LYVE-1 in 63 cases of early gastric carcinoma and 105 cases of advanced gastric carcinoma. The aim of the study is to investigate whether or not increased LVD could be a risk factor for nodal metastasis and survival. We conclude that increased P-LVD, but not I-LVD, could serve as an independent risk factor for nodal metastasis, recurrence and overall survival in gastric carcinoma.
Gao
Peng
P
Department of Pathology, School of Medicine, Shandong University, Jinan Wen Hua Xi Road 44, Jinan 250012, PR China. gaopeng@sdu.edu.cn
Zhou
Geng-Yin
GY
Zhang
Qing-Hui
QH
Xiang
Lei
L
Zhang
Shun-Li
SL
Li
Chao
C
Sun
Yan-Lin
YL
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis; D033921:Vesicular Transport Proteins / Q000032:analysis
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C119248:LYVE1 protein, human; D033921:Vesicular Transport Proteins