Syndromic colon cancer: lynch syndrome and familial adenomatous polyposis.
Colon cancer, the third leading cause of mortality from cancer in the United States, afflicts about 150,000 patients annually. More than 10% of these patients exhibit familial clustering. The most common and well characterized of these familial colon cancer syndromes is hereditary nonpolyposis colon cancer syndrome (Lynch syndrome), which accounts for about 2% to 3% of all cases of colon cancer in the United States. We review the current knowledge of familial cancer syndromes, with an emphasis on Lynch syndrome and familial adenomatous polyposis.
Desai
Tusar K
TK
Division of Gastroenterology, Department of Medicine, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA. tusardesai@aol.com
Barkel
Donald
D
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D053843:DNA Mismatch Repair; D004273:DNA, Neoplasm / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D009017:Morbidity / Q000639:trends; D009154:Mutation / Q000235:genetics*; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm