Genetic factors in common obstetric disorders.
Genetic research of disease has recently turned from individual genes for rare but highly penetrant diseases (like cystic fibrosis) to focus on common, multigene disorders with polygenic inheritance patterns, such as preterm labor, preeclampsia, gestational diabetes, placental abruption, and thromboembolism. These conditions are characterized by multiple etiologies, chronicity, fetal involvement, adaptive clinical manifestations, and gene-environment interactions. As we understand genetic contributions to complex disease and build upon the genetic data and technology available, more effective and specific management and treatment options will become available for clinicians and their patients.
Ward
Kenneth
K
Department of Obstetrics, Gynecology and Women's Health and The Pacific Research Center for Early Human Development, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. ken.ward.hi@mac.com
D000037:Abruptio Placentae / Q000235:genetics; D035843:Biomedical Research; D002874:Chromosome Mapping / Q000379:methods*; D016640:Diabetes, Gestational / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D023281:Genomics; D006801:Humans; D007752:Obstetric Labor, Premature / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D013923:Thromboembolism / Q000235:genetics
D005819:Genetic Markers