title: Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study.
abstract: We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.
authors.affiliation: Department of Pediatrics, University of Calgary, Calgary, AB, Canada. marli.robertson@calgaryhealthregion.ca
authors.forename: Marli A
authors.initials: MA
authors.lastname: Robertson
authors.forename: David L
authors.initials: DL
authors.lastname: Sigalet
authors.forename: Jens J
authors.initials: JJ
authors.lastname: Holst
authors.forename: Jon B
authors.initials: JB
authors.lastname: Meddings
authors.forename: Julie
authors.initials: J
authors.lastname: Wood
authors.forename: Keith A
authors.initials: KA
authors.lastname: Sharkey
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005260:Female; D053767:Glucagon-Like Peptide 2 / Q000097:blood*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D007421:Intestine, Small / Q000503:physiopathology; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism; D010865:Pilot Projects; D012016:Reference Values; D012528:Satiety Response / Q000502:physiology
chemical_list: D053767:Glucagon-Like Peptide 2; D008353:Mannitol; D007792:Lactulose