Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation.
A woman with acute poisoning from extended-release paracetamol presented at 14.5 hours post-ingestion. The paracetamol's absorption phase and elimination half-life appeared prolonged, with peak blood concentration occurring at 20 hours post-ingestion, requiring an extended course of intravenous N-acetylcysteine. Current treatment recommendations, based on experience with a different formulation in the United States, may not be appropriate for the Australian formulation.
Roberts
Darren M
DM
Medical School, Australian National University, Canberra, ACT, Australia. 1darren1@gmail.com
Buckley
Nicholas A
NA
D000042:Absorption; D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000506:poisoning*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000506:poisoning*; D019540:Area Under Curve; D003692:Delayed-Action Preparations; D062787:Drug Overdose / Q000628:therapy; D005260:Female; D006207:Half-Life; D006801:Humans
D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; D000082:Acetaminophen