title: Regulation of DNA repair throughout the cell cycle.
abstract: The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.
authors.affiliation: FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy. dana.branzei@ifom-ieo-campus.it.
authors.forename: Dana
authors.initials: D
authors.lastname: Branzei
authors.forename: Marco
authors.initials: M
authors.lastname: Foiani
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D011494:Protein Kinases