title: The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors.
abstract: Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Yefei
authors.initials: Y
authors.lastname: Han
authors.forename: Jun
authors.initials: J
authors.lastname: Lai
authors.forename: Patricia
authors.initials: P
authors.lastname: Barditch-Crovo
authors.forename: Joel E
authors.initials: JE
authors.lastname: Gallant
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Williams
authors.forename: Robert F
authors.initials: RF
authors.lastname: Siliciano
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
mesh_terms: D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D015236:HLA-C Antigens / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014766:Viremia / Q000235:genetics; D014779:Virus Replication / Q000235:genetics*
chemical_list: C080521:HCP5 long noncoding RNA, human; D015236:HLA-C Antigens; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated