Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat.
An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture, yogurt and commercial drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol (3 g/kg body weight). The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanol-induced toxicity comparable to the commercial drug treatment, according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol (2 g/kg body weight, over one week) provided protection against ethanol toxicity. After the initial set of experiments, the herbal extract mixture and yogurt treatments were extended for three more weeks. When compared to the positive control, further treatment with both the herbal extract and yogurt significantly reduced liver injury and resulted in a lower grade of lipid deposition.
Baek
Min-Won
MW
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
Seok
Seung-Hyeok
SH
Lee
Hui-Young
HY
Kim
Dong Jae
DJ
Lee
Byoung-Hee
BH
Ahn
Young-Tae
YT
Lim
Kwang-Sei
KS
Huh
Chul-Sung
CS
Park
Jae-Hak
JH
D029661:Alnus / Q000737:chemistry*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D029688:Brassica napus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004435:Eating; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007887:Fabaceae / Q000737:chemistry*; D005285:Fermentation; D008099:Liver / Q000473:pathology; D008297:Male; D020944:Silybum marianum / Q000737:chemistry*; D012275:Oryza / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015014:Yogurt
D010936:Plant Extracts; D000431:Ethanol