title: Metabolic syndrome does not impact survival in patients treated for coronary artery disease.
abstract: OBJECTIVE
  We evaluated the effect of metabolic syndrome (a risk factor for the development of coronary artery disease) on survival in patients with established coronary artery disease.
  
  
  METHODS
  Survival was determined for 2886 patients with coronary artery disease diagnosed by cardiac catheterization performed between 1990 and 2005 at a Department of Veterans Affairs hospital. Variables obtained from the computerized medical record were evaluated in multivariate analysis by Cox regression. The analysis was performed for the entire population; separate analyses were performed for patient cohorts treated with percutaneous coronary intervention and medication (n=1274), coronary artery bypass grafting and medication (n=1096), or medication alone (n=516).
  
  
  RESULTS
  Although age (odds ratio 0.948; P<0.000), left ventricular function (odds ratio 0.701; P<0.000), serum creatinine (odds ratio 0.841; P<0.000), and smoking (odds ratio 0.873; P=0.019) were all strong predictors of mortality. Metabolic syndrome had no independent effect irrespective of diabetic status.
  
  
  CONCLUSIONS
  Metabolic syndrome does not impact survival patients with coronary artery disease treated by revascularization and/or medical therapy.
authors.affiliation: VA New York Harbor Health Care System, New York, NY 10010, USA.
authors.forename: Binita
authors.initials: B
authors.lastname: Shah
authors.forename: Nidhi
authors.initials: N
authors.lastname: Kumar
authors.forename: Parveen
authors.initials: P
authors.lastname: Garg
authors.forename: Eunice
authors.initials: E
authors.lastname: Kang
authors.forename: Eugene
authors.initials: E
authors.lastname: Grossi
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lorin
authors.forename: Arthur Z
authors.initials: AZ
authors.lastname: Schwartzbard
authors.forename: Howard
authors.initials: H
authors.lastname: Mass
authors.forename: Ann
authors.initials: A
authors.lastname: Danoff
authors.forename: Steven P
authors.initials: SP
authors.lastname: Sedlis
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D005500:Follow-Up Studies; D006787:Hospitals, Veterans; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome