title: Chitosan-polycarbophil interpolyelectrolyte complex as an excipient for bioadhesive matrix systems to control macromolecular drug delivery.
abstract: The in vitro performance of monolithic matrix systems containing the interpolyelectrolyte complex between chitosan and polycarbophil as excipient was evaluated in terms of their swelling, bioadhesive, and drug release properties. The different matrix systems showed excellent swelling properties without erosion, except for the formulation containing the highest quantity chitosan-polycarbophil complex that exhibited surface erosion in addition to swelling. All the different matrix systems exhibited significantly higher bioadhesive properties than the control group. Furthermore, they showed controlled insulin release without an initial burst release effect. However, only the matrix system that exhibited surface erosion in combination with swelling approached zero-order release.
authors.affiliation: Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa.
authors.forename: Zhilei
authors.initials: Z
authors.lastname: Lu
authors.forename: Weiyang
authors.initials: W
authors.lastname: Chen
authors.forename: Josias H
authors.initials: JH
authors.lastname: Hamman
authors.forename: Jian
authors.initials: J
authors.lastname: Ni
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhai
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000269:Adhesives; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D000180:Acrylic Resins; D000269:Adhesives; D003692:Delayed-Action Preparations; D005079:Excipients; D007004:Hypoglycemic Agents; D007328:Insulin; D013607:Tablets; C030312:calcium polycarbophil; D048271:Chitosan