[Nickel and magnesium effects in the rat kidney, treated with acid retinoic. Comparative study].
Magnesium and nickel are ions with an important role in the human body, but their effects are not completely understood.


OBJECTIVE
To clarify the actions of magnesium and nickel on the rat kidney, which was experimentally treated with retinoic acid, an important therapeutic agent.


METHODS
The first lot of animals was the witness lot and didn't receive any substance. The second lot received retinoic acid, 50 mg/kg weight/day for 30 days. The third lot received retinoic acid in the same way and magnesium acexamate, 0.5 mEq /kg weight/day for 30 days. The fourth lot received retinoic acid in the same way and NiCl2, 0.5 mEq /kg weight/day for 30 days.


RESULTS
The retinoic acid has a toxic effect on the rat kidney. The magnesium decreases this toxic effect but the nickel increases this toxic effect and destroys some urinary tubes.
Scutariu
M D
MD
Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Anatomie şi Fiziologie.
Ciupilan
Corina
C
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D009532:Nickel / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
D000970:Antineoplastic Agents; D014212:Tretinoin; D009532:Nickel; D008274:Magnesium