Glycosides from the bark of Adina polycephala.
Four new dimeric phenolic glycosides (1- 4), a new iridoid diglycoside (5), and 15 known glycosides have been isolated from an ethanolic extract of the bark of Adina polycephala. Their structures were determined by spectroscopic and chemical methods. Compounds 1, 3, and 5 showed in vitro inhibitory activity against the release of beta-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor.
Zhang
Yanling
Y
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
Gan
Maoluo
M
Lin
Sheng
S
Liu
Mingtao
M
Song
Weixia
W
Zi
Jiachen
J
Wang
Sujuan
S
Li
Shuai
S
Yang
Yongchun
Y
Shi
Jiangong
J
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005966:Glucuronidase / Q000187:drug effects / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D039823:Iridoids; D010972:Platelet Activating Factor; D005966:Glucuronidase