Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines.
Angiogenesis is tightly regulated by numerous endogenous pro- and anti-angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro-angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22-24-amino acid peptides derived from the pro-angiogenic ELR-containing CXC chemokines exhibit notable anti-proliferative and anti-migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro-angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis.
Karagiannis
Emmanouil D
ED
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. ekaragi1@jhmi.edu
Popel
Aleksander S
AS
D020816:Amino Acid Motifs; D020533:Angiogenesis Inhibitors / Q000737:chemistry*; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D019743:Chemokines, CXC; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D014471:Umbilical Veins
D020533:Angiogenesis Inhibitors; D019743:Chemokines, CXC; D010446:Peptide Fragments; D010455:Peptides