Lack of association between apolipoprotein E polymorphism and vascular dementia in Koreans.
To investigate an association of vascular dementia (VD) with the apolipoprotein E (APOE) polymorphism, the APOE polymorphism of 100 VD patients, 100 age- and gender-matched Alzheimer disease (AD) patients, and 200 age- and gender-matched nondemented control (NC) subjects was genotyped. The distribution of APOE polymorphism was compared. Neither the APOE epsilon4 allele nor the APOE epsilon2 allele was more prevalent in the VD patients compared with the NC subjects (P > .1 by the chi 2 test), which was the case when both men and women were analyzed separately (P > .1 by the chi2 test) and when young patients (75 years old or less) and old patients (more than 75 years old) were analyzed separately (P > .1 by the chi2 test). The estimated statistical power was over 0.80 when the odds ratios (OR) for VD conferred to the APOE epsilon4 are assumed to be higher than 2.2 and the type I error probability is set at 0.05, which is much higher than the power of the previous studies on the VD/APOE association. In conclusion, the results suggested that APOE epsilon4 allele does not confer the risk for VD, and even if it does, it does so very modestly.
Kim
Ki Woong
KW
Department of Neuropsychiatry and Stroke Center, Seoul National University Bundang Hospital, Seongnam, Korea.
Youn
Jong-Chul
JC
Han
Moon-Ku
MK
Paik
Nam Jong
NJ
Lee
Tae Joo
TJ
Park
Joon Hyuk
JH
Lee
Seok Bum
SB
Choo
Il Han
IH
Lee
Dong Young
DY
Jhoo
Jin Hyeong
JH
Woo
Jong Inn
JI
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D015140:Dementia, Vascular / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
D001057:Apolipoproteins E