[Effect of cationic and anionic amphiphilic compounds on hypertonic cryohemolysis of mammalian red blood cells].
We studied the effect of derivatives of anionic (sodium decyl- and dodecyl- sulphate) and cationic (trifluoperazine, chlorpromazine) amphiphilic compounds on morphological peculiarities and hypertonic cryohemolysis of human, rabbit, bovine, equine red blood cells. The mentioned substances cause changes in red blood cell shape for all the studied mammals: anionic amphiphils on the discocyte-echinocyte type and cationic ones on discocyte-stomatocyte type. It was revealed a significant antihemolytic activity of the studied substances under hypertonic cryohemolysis of mammalian red blood cells with manifested species differences in the efficiency. The most effective are cationic trifluoperazine and anionic sodium decylsulphate, moreover the latter is much more active for animal red blood cells if compared with human ones.
Iershov
S S
SS
Pysarenko
N A
NA
Orlova
N V
NV
Shpakova
N M
NM
D000818:Animals; D000838:Anions / Q000494:pharmacology; D002412:Cations / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D003470:Culture Media; D004912:Erythrocytes / Q000187:drug effects*; D005615:Freezing; D006461:Hemolysis / Q000187:drug effects*; D006736:Horses; D006801:Humans; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013045:Species Specificity; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*
D000838:Anions; D002412:Cations; D003470:Culture Media; D012462:Saline Solution, Hypertonic; D013501:Surface-Active Agents