title: [Reconstruction of the anterior wall of frontal sinus with biopolymers].
abstract: The two biopolymers Ethisorb and its modification Ethisorb Rapid were implanted in 80 defects of the anterior wall of frontal sinus in 20 Goettingen minipigs to analyze density of trabecula (Mann-Whtiney-Rank-Sum-Test), degradation of biopolymers and histomorphology. To optimate bone regeneration, particular resorbable membranes and autogenic spongiosa chips were used. The animals were killed after six, 12, 26 and 52 weeks and then postoperative undecalcified bone cuts were obtained. All in all, with Ethisorb contrary to Ethisorb Rapid a faster biopolymer resorption in the 12th and 26th week with a statistically significant greater density of trabecula could be observed. The use of resorbable membranes and autogenic spongiosa chips led, in comparison to simple implantation of biopolymers, to significantly greater densities of trabecula. The use of Ethisorb contrary to Ethisorb Rapid with membranes led to a Guided Bone Regeneration (GBR) with persistence of membrane particles to week 12 and 26. By mixing biopolymers with autogenic spongiosa chips a multiloculated bone regeneration could be generated. For Ethisorb with resorbable membranes and autogenic spongiosa chips the best bone regeneration with highest densities of trabecula could be recognized.
authors.affiliation: Klinik und Poliklinik für Neurochirurgie, Georg-August-Universität Göttingen. axel.nitsch@gmx.de
authors.forename: Axel
authors.initials: A
authors.lastname: Nitsch
authors.forename: Raphaela
authors.initials: R
authors.lastname: Verheggen
authors.forename: Jörg
authors.initials: J
authors.lastname: Holste
authors.forename: Hans-Albert
authors.initials: HA
authors.lastname: Merten
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001704:Biopolymers; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D005626:Frontal Sinus / Q000601:surgery*; D048091:Guided Tissue Regeneration / Q000379:methods*; D008567:Membranes, Artificial; D011091:Polyesters; D011100:Polyglycolic Acid; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001704:Biopolymers; D018786:Bone Substitutes; C460779:Ethisorb; D008567:Membranes, Artificial; D011091:Polyesters; D011100:Polyglycolic Acid