title: Efficacy of oxyclozanide against the rumen fluke Calicophoron daubneyi in experimentally infected goats.
abstract: Paramphistome infections are very common in ruminants and may induce clinical signs, but little is known about effective treatments. In this study, the efficacy of oxyclozanide against Calicophoron daubneyi was studied in goats and its activity tested against immature stages (10 days post-infection) at a dose of 22.5mg/kg bodyweight (BW) and against adult stages using two doses (15 and 22.5mg/kg BW). There was a reduction (82%) in the number of immature worms (compared to controls) but the result was not statistically significant. When tested against adult stages, however, oxyclozanide reduced the worm burdens by 95.6% and 95.9% at doses of 15 and 22.5mg/kg BW, respectively, with no significant difference between the two doses. The experiment demonstrated that oxyclozanide is highly effective in reducing the number of adult paramphistomes in goats.
authors.affiliation: French Food Safety Agency (AFSSA), Laboratoire d'Etudes et de Recherches Caprines, 60 rue de Pied de Fond, 79012 NIORT Cedex, France. c.paraud@niort.afssa.fr
authors.forename: C
authors.initials: C
authors.lastname: Paraud
authors.forename: C
authors.initials: C
authors.lastname: Gaudin
authors.forename: I
authors.initials: I
authors.lastname: Pors
authors.forename: C
authors.initials: C
authors.lastname: Chartier
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology*; D006041:Goats; D010097:Oxyclozanide / Q000627:therapeutic use*; D010250:Paramphistomatidae / Q000254:growth & development*; D013272:Stomach Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D014201:Trematode Infections / Q000188:drug therapy* / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000980:Antiplatyhelmintic Agents; D010097:Oxyclozanide