Collapsing glomerulopathy: many means to a similar end.
Collapsing glomerulopathy (CG) represents a morphologic pattern of disease, characterized histologically by glomerular capillary collapse, severe podocyte injury, and glomerular epithelial cell proliferation, and clinically by marked proteinuria and renal insufficiency. CG has multiple etiologies; however, many questions remain about its pathogenesis. A new set of animal models of CG, characterized by absence of the normal podocyte cytoskeletal protein alpha-actinin-4, has potential to help us gain a greater understanding of cellular events involved in producing this pattern of disease.
Haas
M
M
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. mhaas@jhmi.edu
D000185:Actinin / Q000172:deficiency* / Q000235:genetics; D000818:Animals; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000209:etiology* / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout
C491752:Actn4 protein, mouse; D000185:Actinin