title: 3D MR flow analysis in realistic rapid-prototyping model systems of the thoracic aorta: comparison with in vivo data and computational fluid dynamics in identical vessel geometries.
abstract: The knowledge of local vascular anatomy and function in the human body is of high interest for the diagnosis and treatment of cardiovascular disease. A comprehensive analysis of the hemodynamics in the thoracic aorta is presented based on the integration of flow-sensitive 4D MRI with state-of-the-art rapid prototyping technology and computational fluid dynamics (CFD). Rapid prototyping was used to transform aortic geometries as measured by contrast-enhanced MR angiography into realistic vascular models with large anatomical coverage. Integration into a flow circuit with patient-specific pulsatile in-flow conditions and application of flow-sensitive 4D MRI permitted detailed analysis of local and global 3D flow dynamics in a realistic vascular geometry. Visualization of characteristic 3D flow patterns and quantitative comparisons of the in vitro experiments with in vivo data and CFD simulations in identical vascular geometries were performed to evaluate the accuracy of vascular model systems. The results indicate the potential of such patient-specific model systems for detailed experimental simulation of realistic vascular hemodynamics. Further studies are warranted to examine the influence of refined boundary conditions of the human circulatory system such as fluid-wall interaction and their effect on normal and pathological blood flow characteristics associated with vascular geometry.
authors.affiliation: Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Canstein
authors.forename: P
authors.initials: P
authors.lastname: Cachot
authors.forename: A
authors.initials: A
authors.lastname: Faust
authors.forename: A F
authors.initials: AF
authors.lastname: Stalder
authors.forename: J
authors.initials: J
authors.lastname: Bock
authors.forename: A
authors.initials: A
authors.lastname: Frydrychowicz
authors.forename: J
authors.initials: J
authors.lastname: Küffer
authors.forename: J
authors.initials: J
authors.lastname: Hennig
authors.forename: M
authors.initials: M
authors.lastname: Markl
mesh_terms: D001013:Aorta, Thoracic / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D003287:Contrast Media; D005240:Feasibility Studies; D019786:Gadolinium DTPA; D006439:Hemodynamics; D006801:Humans; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D011673:Pulsatile Flow
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA