title: Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A.
abstract: Total synthesis of salvinorin A (1), a neoclerodane diterpenoid having the most potent hallucinogenic activity and a selective kappa-opioid agonist, was completed in 20 steps starting from enantiomerically pure hydroxy-Wieland-Miescher ketone 5.
authors.affiliation: Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Nishi-ku, Niigata 950-2181, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Nozawa
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Suka
authors.forename: Takashi
authors.initials: T
authors.lastname: Hoshi
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Hagiwara
mesh_terms: D045785:Diterpenes, Clerodane / Q000138:chemical synthesis* / Q000737:chemistry; D006213:Hallucinogens / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D027544:Salvia / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D045785:Diterpenes, Clerodane; D006213:Hallucinogens; C090499:salvinorin A