Midlife C-reactive protein and risk of cognitive decline: a 31-year follow-up.
There is evidence for a relationship between raised inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), measured late in life, and an increased risk of cognitive decline and dementia. This study evaluates the association of midlife hs-CRP concentrations with late-life longitudinal trends in cognitive function. Data are from the Honolulu-Asia Aging Study (HAAS), a longitudinal community-based study of Japanese American men. hs-CRP levels were measured on average 25 years before cognitive testing began in 1991. Subjects were followed from up to three follow-up examinations (mean of 6.1 years). At each exam, cognitive function was measured with the Cognitive Abilities Screening Instrument (CASI). This analysis includes a sub-sample of 691 subjects dementia-free in 1991. With incident dementia cases included, those with the highest quartile of hs-CRP had significantly more cognitive decline than those in the lowest quartile, after adjustment for baseline CASI score, demographic and cardiovascular risk factors. When cases were removed, there was no difference in cognitive decline by CRP quartile. This relationship was not modified by the presence of apolipoprotein E varepsilon4. These findings suggest that inflammatory mechanisms during midlife may reflect underlying processes contributing to dementia-related cognitive decline late in life.
Laurin
Danielle
D
Laval University Geriatrics Research Unit, Centre de recherche du CHA, and Faculty of Pharmacy, Laval University, 1050 Chemin Sainte-Foy, Local L2-30, Quebec City, Quebec G1S 4L8, Canada.
David Curb
J
J
Masaki
Kamal H
KH
White
Lon R
LR
Launer
Lenore J
LJ
D000368:Aged; D000369:Aged, 80 and over; D001213:Asian; D002097:C-Reactive Protein / Q000378:metabolism*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000378:metabolism*; D015577:Geriatric Assessment; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D012111:Residence Characteristics; D018570:Risk Assessment; D012307:Risk Factors
D002097:C-Reactive Protein