Baroreceptors mask sympathetic responses to high intraocular pressure in dogs.
These experiments were designed to investigate whether increasing intraocular pressure (IOP) in anesthetized dogs produces differential control of sympathetic nerve activities to various organs (heart, kidney, liver, and spleen) and if these sympathetic responses are modified by baroreceptors. We performed simultaneous multi-recordings of cardiac, renal, hepatic and splenic sympathetic nerve activities (CNA, RNA, HNA and SpNA, respectively) during 2 min of increasing IOP to a mean pressure of 30 mmHg. After increasing IOP in dogs with the intact baroreceptors, all of measured nerve activities did not change significantly throughout the experiment. In dogs with denervation of baroreceptors (cervical vagotomy with denervation of the carotid sinus and aortic nerves), only RNA and CNA showed significant increases in response to the increased IOP. However, time course changes in HNA and SpNA did not show any significant differences as compared with the baseline or that of the control group. These results indicate that systemic sympathetic nerve responses to increasing IOP are masked by systemic baroreceptors. As animals were denervated of their systemic baroreceptors, the unidirectional sympathoexcitatory responses to increased IOP were observed on CNA and RNA, but not on HNA and SpNA. These sympathetic outflow, when systemic baroreceptors are impaired as observed in old age, may play an important role in management of glaucoma attack with the use of adrenolytic drugs.
Yahagi
Toru
T
Shinshu University School of Medicine, Department of Integrative Physiology and System Control, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan.
Koyama
Shozo
S
Osaka
Kazumasa
K
Koyama
Haruhide
H
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000502:physiology; D007022:Hypotension / Q000503:physiopathology*; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors