Failure of prophylactic zinc in Wilson disease.
Early institution of prophylactic therapy of asymptomatic Wilson disease patients can prevent the expression of the disease. Zinc is currently preferred therapy for presymptomatic patients. We report onset of symptomatic disease in a presymptomatic patient and deterioration of biochemical parameters in another, despite appropriate zinc therapy.
Mishra
Devendra
D
Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India.
Kalra
Veena
V
Seth
Rachna
R
D001921:Brain / Q000473:pathology; D002648:Child; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017211:Treatment Failure; D015032:Zinc / Q000627:therapeutic use*
D015032:Zinc