title: Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging.
abstract: BACKGROUND
  Diastolic dysfunction is common in patients with overt hypertrophic cardiomyopathy (HCM). Steady-state cine magnetic resonance imaging (MRI) enables measurement of the diastolic function of the left ventricle (LV), and late gadolinium enhanced MRI can delineate the presence and extent of fibrosis in HCM. The purpose of this study was to determine the relationship between the extent of myocardial fibrosis demonstrated by late gadolinium-enhanced MRI and diastolic dysfunction.
  
  
  RESULTS
  Seventeen patients (13 men, mean age 57.7+/-9.8 years) with HCM were studied. The severity index of late gadolinium enhancement was determined by scoring the extent of enhanced tissue in 30 myocardial segments. The peak filling rate (PFR), LV ejection fraction and LV mass were determined by cine MRI. Contrast-enhanced MRI demonstrated late gadolinium enhancement in 97 of 510 segments (19%) and 13 of the 17 patients (77%). The severity index of late gadolinium enhancement demonstrated a significant negative correlation with PFR (r= -0.86, p<0.01) and with the LV ejection fraction (r= -0.59, p<0.05). No significant correlation was observed between the severity index of late gadolinium enhancement and LV mass (r=0.23, p=0.30).
  
  
  CONCLUSIONS
  The extent of myocardial fibrosis revealed by late gadolinium-enhanced MRI has a strong relationship to diastolic dysfunction in patients with HCM.
authors.affiliation: Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Munenobu
authors.initials: M
authors.lastname: Motoyasu
authors.forename: Tairo
authors.initials: T
authors.lastname: Kurita
authors.forename: Katsuya
authors.initials: K
authors.lastname: Onishi
authors.forename: Shoko
authors.initials: S
authors.lastname: Uemura
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Okinaka
authors.forename: Kan
authors.initials: K
authors.lastname: Takeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakano
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
authors.forename: Hajime
authors.initials: H
authors.lastname: Sakuma
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005355:Fibrosis; D005682:Gadolinium; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*
chemical_list: D005682:Gadolinium