title: Ropinirole treatment for restless legs syndrome.
abstract: BACKGROUND
  Restless legs syndrome (RLS) is a chronic neurological disorder associated with sleep disturbance.
  
  
  OBJECTIVE
  Prepare a drug evaluation of the non-ergot dopamine agonist ropinirole in RLS.
  
  
  METHODS
  Review of scientific literature on RLS, particularly focusing on treatment with ropinirole.
  
  
  CONCLUSIONS
  Ropinirole has been studied for treatment of moderate to severe primary RLS in a comprehensive clinical development program. Ropinirole significantly improved symptoms of RLS, versus placebo, in patients with primary RLS. These improvements are supported by data from individual studies and pooled analyses. Significant improvements in RLS symptoms were observed within two nights of treatment. Ropinirole also produced significant benefits on objective measures of RLS motor symptoms, such as periodic leg movements, and subjective measures of sleep. Ropinirole was generally well tolerated.
authors.affiliation: SleepMed of South Carolina, 1333 Taylor St, Suite 6B, Columbia, SC 29201, USA. rbogan@sleepmed.md
authors.forename: Richard K
authors.initials: RK
authors.lastname: Bogan
mesh_terms: D018491:Dopamine Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D007211:Indoles; C046649:ropinirole