Epidermal growth factor receptor inhibitors in the treatment of lung cancer: reality and hopes.
OBJECTIVE
Inhibition of the epidermal growth factor receptor (EGFR) is now an established part of the treatment of nonsmall cell lung cancer. This review summarizes the clinical trials that have been performed with monoclonal antibodies and small molecule tyrosine kinase inhibitors targeting EGFR in nonsmall cell lung cancer.


RESULTS
Erlotinib has established second and third-line efficacy following the BR.21 study. Recently the INTEREST trial showed gefitinib to have an equivalent outcome to docetaxel in the second line setting. Numerous other tyrosine kinase inhibitor drugs and monoclonal antibodies have demonstrated clinical activity in phase I and phase II trials. Novel tyrosine kinase inhibitors may have the ability to overcome resistance to first generation tyrosine kinase inhibitor therapy. Furthermore there are encouraging studies combining EGFR inhibitors and antiangiogenesis drugs such as bevacizumab.


CONCLUSIONS
EGFR inhibition, by a range of strategies, remains a central node in the treatment of nonsmall cell lung cancer.
Wheatley-Price
Paul
P
University Health Network, Princess Margaret Hospital Division and the University of Toronto, Toronto, Ontario, Canada.
Shepherd
Frances A
FA
D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000628:therapy*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors