Chiral induction in phenanthroline-derived oligoamide foldamers: an acid- and base-controllable switch in helical molecular strands.
A series of phenanthroline-derived oligoamides bearing a chiral (R)-phenethylamino end group were synthesized that displayed chiral helical induction and subsequently formed one-hand helical foldamers in solution. Moreover, an acid- and base-controllable switch in the helical molecular strands was observed, which has been demonstrated by NMR, UV-vis, and circular dichroism spectroscopy.
Hu
Hai-Yu
HY
Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Xiang
Jun-Feng
JF
Yang
Yong
Y
Chen
Chuan-Feng
CF
D000143:Acids / Q000737:chemistry; D000468:Alkalies / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D010618:Phenanthrolines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000143:Acids; D000468:Alkalies; D000577:Amides; D010618:Phenanthrolines