title: Diagnostic value of ischaemia-modified albumin for predicting myocardial ischaemia during myocardial perfusion scintigraphy.
abstract: During acute ischaemia the N-terminal site of albumin is altered, reducing its binding capacity; the modified protein is termed ischaemia-modified albumin (IMA). IMA is a sensitive marker of acute myocardial ischaemia but its diagnostic value in chronic angina pectoris patients is unclear. We investigated changes in blood levels of IMA during myocardial perfusion scintigraphy in patients with chronic angina pectoris in a study including 26 male and 20 female patients, with mean age 60 years. Technetium 99m perfusion imaging detected myocardial ischaemia in 26 patients. Coronary angiography was carried out in these 26 ischaemic patients. Mean IMA values at rest and peak exercise were significantly higher in the ischaemic than the nonischaemic group. All IMA values were considered negative for cardiac ischaemia. Peak exercise IMA was significantly lower than the pre-exercise level only in the non-ischaemic group. IMA measurements during myocardial perfusion scintigraphy are not helpful in the diagnosis of myocardial ischaemia in patients with stable angina pectoris.
authors.affiliation: Department of Cardiology, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: B Y
authors.initials: BY
authors.lastname: Cingozbay
authors.forename: N
authors.initials: N
authors.lastname: Ozmen
authors.forename: N
authors.initials: N
authors.lastname: Canbolat
authors.forename: M
authors.initials: M
authors.lastname: Aparci
authors.forename: E
authors.initials: E
authors.lastname: Kardeşoğlu
authors.forename: Y
authors.initials: Y
authors.lastname: Narin
authors.forename: M
authors.initials: M
authors.lastname: Gultepe
authors.forename: B S
authors.initials: BS
authors.lastname: Cebeci
authors.forename: M
authors.initials: M
authors.lastname: Dincturk
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis*; D002908:Chronic Disease; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis*; D015425:Myocardial Reperfusion; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging / Q000379:methods*; D012709:Serum Albumin / Q000032:analysis*; D013667:Technetium
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D013667:Technetium