title: Prevalence of ceftriaxone-induced red blood cell antibodies in pediatric patients with sickle cell disease and human immunodeficiency virus infection.
abstract: Ceftriaxone can be associated with catastrophic immune hemolysis in pediatric patients, particularly those with underlying diseases such as sickle cell disease and human immunodeficiency virus infection. We designed a study to screen for ceftriaxone-induced RBC antibodies in these 2 pediatric populations. The prevalence of anticeftriaxone antibody was 12.5% (8 of 64). Two of these 8 patients with the antibody experienced hemolysis; 1 case was fatal.
authors.affiliation: Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, MA 02118, USA. kq@bu.edu
authors.forename: Karen
authors.initials: K
authors.lastname: Quillen
authors.forename: Catherine
authors.initials: C
authors.lastname: Lane
authors.forename: Edward
authors.initials: E
authors.lastname: Hu
authors.forename: Stephen
authors.initials: S
authors.lastname: Pelton
authors.forename: Scot
authors.initials: S
authors.lastname: Bateman
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001323:Autoantibodies / Q000097:blood*; D002443:Ceftriaxone / Q000009:adverse effects* / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D015658:HIV Infections / Q000150:complications*; D006461:Hemolysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
chemical_list: D001323:Autoantibodies; D002443:Ceftriaxone