title: Effect of topical ciprofloxacin/dexamethasone or dexamethasone alone on acute Streptococcus pneumoniae rhinosinusitis in mice.
abstract: OBJECTIVE
  To test whether intranasal ciprofloxacin/dexamethasone or dexamethasone alone affects the course of acute bacterial rhinosinusitis in mice.
  
  
  METHODS
  We performed a randomized, double-blind, parallel, placebo-controlled study in mice.
  
  
  METHODS
  Three groups of 10 C57Bl/6 mice were infected with Streptococcus pneumoniae, and then 1 day later randomized to treatment with placebo, ciprofloxacin plus dexamethasone, or dexamethasone. The mice were killed 3 or 10 days after treatment was begun.
  
  
  RESULTS
  The placebo-treated mice became infected and developed an inflammatory cell infiltration in their sinuses. None of the treatments significantly affected the course of the illness.
  
  
  CONCLUSIONS
  The lack of topical, intranasal efficacy of ciprofloxacin and dexamethasone could be attributed to subpotent dosage, rapid nasal clearance, or inability of the drops to reach the site of infection. Treatment with dexamethasone neither improved nor worsened the bacterial infection.
authors.affiliation: Department of Surgery, Section of Otolaryngology Head and Neck Surgery, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Asli
authors.initials: A
authors.lastname: Sahin-Yilmaz
authors.forename: Fuad
authors.initials: F
authors.lastname: Baroody
authors.forename: Adam
authors.initials: A
authors.lastname: Markaryan
authors.forename: Kenneth
authors.initials: K
authors.lastname: Thompson
authors.forename: G Michael
authors.initials: GM
authors.lastname: Wall
authors.forename: Robert
authors.initials: R
authors.lastname: Naclerio
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D015169:Colony Count, Microbial; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005434:Flow Cytometry; D051379:Mice; D008810:Mice, Inbred C57BL; D011008:Pneumococcal Infections / Q000188:drug therapy*; D012220:Rhinitis / Q000188:drug therapy* / Q000382:microbiology*; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology*; D020858:Tissue and Organ Harvesting
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D003907:Dexamethasone