title: Stereoselective synthesis of trisubstituted E-iodoalkenes by indium-catalyzed syn-addition of 1,3-dicarbonyl compounds to 1-iodoalkynes.
abstract: Indium-catalyzed addition of 1,3-dicarbonyl compounds to 1-iodo-1-alkynes takes place exclusively in a syn-fashion to produce E-iodoalkenes. The iodine atom serves both as an activating group and as a group that controls the regioselectivity of the addition. The E-alkenyl iodide product can be further derivatized using either a one-pot or a two-pot procedure into trisubstituted olefins in high overall yield with retention of the stereochemistry.
authors.affiliation: Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Tsuji
authors.forename: Taisuke
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Endo
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura