title: Pulmonary complaints and lung function after pediatric kidney transplantation.
abstract: Recently four of 38 children with a kidney transplant were diagnosed with bronchiectasis. The aim of the current study was to identify patients with increased risk for pulmonary damage. In this cross-sectional observational study, children with a functioning kidney graft in the Netherlands and Antwerp, Belgium, were screened with the use of a symptom checklist and spirometry. Maximum score for upper airway complaints was 21 (normal: <8), for lower airway complaints 28 (<10). Results of FVC, FEV(1) and MEF(25) were expressed as percentage predicted for height and sex. One hundred and thirty-five patients completed the interview (122) and/or spirometry (103); 91 did both. Lower airways symptoms were above acceptable levels in 18 (14%) patients. Forty-nine patients (48%) had an abnormal lung function test: in 12 concerning FVC%, in 11 FEV(1)%, in 24 MEF(25)% and in 36 FEV(1)/FVC. Of correlations between symptomatology or spirometry data, and clinical parameters, only that between GFR and MEF(25)% was statistically significant. Children with a kidney transplant are at increased risk for obstructive lung disease. We recommend to monitor lung function during the follow-up after renal transplantation.
authors.affiliation: Department of Pediatric Nephrology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands. k.cransberg@erasmusmc.nl
authors.forename: Karlien
authors.initials: K
authors.lastname: Cransberg
authors.forename: Mariëlle
authors.initials: M
authors.lastname: Pijnenburg
authors.forename: Maaike
authors.initials: M
authors.lastname: Lunstroot
authors.forename: Marc
authors.initials: M
authors.lastname: Lilien
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Cornelissen
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Davin
authors.forename: Koen
authors.initials: K
authors.lastname: VanHoeck
authors.forename: Peter
authors.initials: P
authors.lastname: Merkus
authors.forename: Jeroen
authors.initials: J
authors.lastname: Nauta
mesh_terms: D001987:Bronchiectasis / Q000175:diagnosis / Q000209:etiology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology*; D012129:Respiratory Function Tests; D013147:Spirometry