title: Contemporary results with ampullectomy for 29 "benign" neoplasms of the ampulla.
abstract: BACKGROUND
  Ampullectomy may be an appropriate oncologic procedure in selected patients. Sparse data exist on procedure-related complications and the relationship between histologic analysis and outcomes.
  
  
  METHODS
  We retrospectively reviewed our experience with ampullectomy in 29 patients with a preoperative benign histologic diagnosis over 15 years (1991 to 2006). Presenting signs, symptoms, and preoperative diagnostic studies were reviewed. Postoperative complications and followup for recurrence were recorded. The abilities of preoperative histologic biopsy, intraoperative frozen section, and final histologic analysis to guide management and predict outcomes were determined.
  
  
  RESULTS
  Median age was 63 years. Jaundice was present in 30% of patients. Median length of hospital stay was 9 days. Forty-five percent of patients had a complication, and there was one postoperative mortality (3%). Ampullary adenomatous neoplasms were present in 89% of patients. Preoperative biopsy had complete concordance with final pathology in 76% of patients. Preoperative biopsy and intraoperative frozen section failed to identify carcinoma in four patients. Pancreaticoduodenectomy was performed within 7 days in the postoperative period in three of these patients. After ampullectomy (median followup=16 months), recurrences were identified in two patients (8%) with benign tumors. No patients with high-grade dysplasia (n=4) have had recurrence.
  
  
  CONCLUSIONS
  Preoperative biopsy and intraoperative frozen section analysis have limitations in the management of patients undergoing ampullectomy. High-grade dysplasia on preoperative biopsy is not an absolute contraindication to ampullectomy. Morbidity of ampullectomy is significant, but longterm outcomes of this procedure, in patients without invasive malignancy, are acceptable.
authors.affiliation: Division of Surgical Oncology and Endocrine Surgery, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Grobmyer
authors.forename: Chad N
authors.initials: CN
authors.lastname: Stasik
authors.forename: Peter
authors.initials: P
authors.lastname: Draganov
authors.forename: Alan W
authors.initials: AW
authors.lastname: Hemming
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Dixon
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Vogel
authors.forename: Steven N
authors.initials: SN
authors.lastname: Hochwald
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D003138:Common Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016896:Treatment Outcome