title: Psychiatric comorbidity in epilepsy: a study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy.
abstract: We evaluated the frequency of psychiatric disorders (PDs) in a homogenous series of patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS), as compared with patients with juvenile myoclonic epilepsy (JME), aiming to determine possible differences in psychiatric diagnoses between these two epileptic syndromes. Data from 170 patients with refractory TLE-MTS and from 100 patients with JME were reviewed and compared. The prevalence of PDs was high in both groups of patients with epilepsy: PDs were present in 85 patients with TLE-MTS (50%) and 49 patients with JME (49%). Among the TLE-MTS group, mood (25.8%), psychotic (15.8%), and anxiety (14.1%) disorders were the most frequent diagnoses, whereas anxiety and mood disorders (23 and 19%, respectively) were the most common among patients with JME. Psychoses were significantly associated with MTS (P<0.01) and anxiety disorders with JME (P<0.05). These findings suggest the existence of an anatomic correlation between PDs and brain structures involved in both epilepsy syndromes.
authors.affiliation: Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Gerardo Maria de Araújo
authors.initials: GM
authors.lastname: Filho
authors.forename: Vivianne Pellegrino
authors.initials: VP
authors.lastname: Rosa
authors.forename: Katia
authors.initials: K
authors.lastname: Lin
authors.forename: Luís Otávio Sales Ferreira
authors.initials: LO
authors.lastname: Caboclo
authors.forename: Américo Ceiki
authors.initials: AC
authors.lastname: Sakamoto
authors.forename: Elza Márcia Targas
authors.initials: EM
authors.lastname: Yacubian
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D008875:Middle Aged; D020190:Myoclonic Epilepsy, Juvenile / Q000453:epidemiology*; D012189:Retrospective Studies; D012598:Sclerosis / Q000453:epidemiology; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000473:pathology*