[Preparation of liposomes containing extracts of Tripterygium wilfordii and evaluation of its stability].
OBJECTIVE
The liposomes containing extracts of Tripterygium wilfordii were prepared and the possibility of entrapment of complex chemicals by liposomes were studied.


METHODS
The liposomes containing extracts of T. wilfordii were prepared by thin-film dispersion method, the effect of process parameters and composition of materials on the entrapment efficiency of the main components were studied. The stability of the liposomes dispersion was also evaluated.


RESULTS
The liposomes made by thin-film dispersion method were mostly small unilamellar vesicles and their particle size was 30 nm to approximately 50 nm. The optimum entrapment efficiency of tripterine and the total alkaloids were respectively 98.10% and 88.63% but the liposomes dispersion was unstable when kept at 4 degrees C.


CONCLUSIONS
The complex chemicals can be entrapped by the liposomes, but its stability need to be improved furtherly.
Li
Hong-Ru
HR
Key Laboratory for Green Chemical Technologies of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Li
Shu-Fen
SF
Duan
Hong-Quan
HQ
D000470:Alkaloids / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D053978:Pentacyclic Triterpenes; D013696:Temperature; D013997:Time Factors; D029757:Tripterygium / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry
D000470:Alkaloids; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D008081:Liposomes; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D002784:Cholesterol; C050414:celastrol