Formal total synthesis of triptolide.
A new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels-Alder reactions and a new deoxygenative aromatisation process.
Miller
Natalie A
NA
Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
Willis
Anthony C
AC
Sherburn
Michael S
MS
D004224:Diterpenes / Q000138:chemical synthesis*; D004852:Epoxy Compounds / Q000138:chemical synthesis; D010616:Phenanthrenes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; C001899:triptolide