Experimental models of hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is a common and deadly cancer whose pathogenesis is incompletely understood. Comparative genomic studies from human HCC samples have classified HCCs into different molecular subgroups; yet, the unifying feature of this tumor is its propensity to arise upon a background of inflammation and fibrosis. This review seeks to analyze the available experimental models in HCC research and to correlate data from human populations with them in order to consolidate our efforts to date, as it is increasingly clear that different models will be required to mimic different subclasses of the neoplasm. These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies.
Newell
Philippa
P
Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
Villanueva
Augusto
A
Friedman
Scott L
SL
Koike
Kazuhiko
K
Llovet
Josep M
JM
D000818:Animals; D030801:Animals, Genetically Modified; D002453:Cell Cycle; D004195:Disease Models, Animal; D023281:Genomics; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D009368:Neoplasm Transplantation; D016615:Telomere; D014183:Transplantation, Heterologous