Lignans from the fruits of Forsythia suspensa.
Bioactivity-guided fractionation of the methanol extract of the fruits of Forsythia suspensa Vahl has led to the isolation of two new monoepoxylignans, forsythialan A (1) and B (2), together with a known tetrahydrofurofuran lignan, phillyrin (3). The structures of compounds 1 and 2 were elucidated by spectroscopic methods. The antioxidant activities of these lignans have been assessed by evaluating their protective effects against peroxynitrite-induced oxidative stress. The compounds 1 and 2 showed protective effects against renal epithelial cell injury by 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator. The relatively stronger antioxidant activities of compounds 1 and 2 may be associated with the presence of aromatic hydroxy function.
Piao
Xiang-Lan
XL
Chinese Minority Traditional Medical Center, College of Life and Environmental Sciences, Central University for Nationalities, Beijing 100081, China. piaoxsh@mafic.ac.cn
Jang
Moon Hee
MH
Cui
Jian
J
Piao
Xiangshu
X
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D031657:Forsythia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D005663:Furans / Q000737:chemistry; D005960:Glucosides / Q000494:pharmacology; D018374:LLC-PK1 Cells / Q000378:metabolism; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D030421:Peroxynitrous Acid / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013552:Swine
D000975:Antioxidants; D005663:Furans; D005960:Glucosides; D017705:Lignans; D020030:Nitric Oxide Donors; D010936:Plant Extracts; C529329:forsythialan A; C529330:forsythialan B; D030421:Peroxynitrous Acid; C018674:tetrahydrofuran; C002385:linsidomine; D008981:Molsidomine; C075528:phillyrin