Stress-response hormesis and aging: "that which does not kill us makes us stronger".
Hormesis refers to the beneficial effects of a treatment that at a higher intensity is harmful. In one form of hormesis, sublethal exposure to stressors induces a response that results in stress resistance. The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models.
Gems
David
D
Institute of Healthy Ageing and Department of Genetics, Environment and Evolution, University College London, London WC1E 6BT, UK.
Partridge
Linda
L
D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D031204:Caloric Restriction; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D013312:Stress, Physiological / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology
D004785:Environmental Pollutants; D007328:Insulin; D007334:Insulin-Like Growth Factor I