title: MR analysis of regional brain volume in adolescent idiopathic scoliosis: neurological manifestation of a systemic disease.
abstract: OBJECTIVE
  To investigate whether regional brain volumes in adolescent idiopathic scoliosis (AIS) patients differ from matched control subjects as AIS subjects are reported to have poor performance on combined visual and proprioceptive testing and impaired postural balance in previous studies.
  
  
  METHODS
  Twenty AIS female patients with typical right-convex thoracic curve (age range,11-18 years; mean, 14.1 years) and 26 female controls (mean age, 14.8 years) underwent three-dimensional magnetization prepared rapid acquisition gradient echo (3D-MPRAGE) MR imaging. Volumes of 99 preselected neuroanatomical regions were compared by statistical parametric mapping and atlas-based hybrid warping.
  
  
  RESULTS
  Analysis of variance statistics revealed significant mean volumetric differences in 22 brain regions between AIS and controls. Ten regions were larger in AIS including the left frontal gyri and white matter in left frontal, parietal, and temporal regions, corpus callosum and brainstem. Twelve regions were smaller in AIS, including right-sided descending white matter tracts (anterior and posterior limbs of the right internal capsule and the cerebral peduncle) and deep nucleus (caudate), bilateral perirhinal cortices, left hippocampus and amygdala, bilateral precuneus gyri, and left middle and inferior occipital gyri.
  
  
  CONCLUSIONS
  Regional brain volume difference in AIS subjects may help to explain neurological abnormalities in this group.
authors.affiliation: Functional and Molecular Imaging Center, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
authors.forename: Winnie C W
authors.initials: WC
authors.lastname: Chu
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Young
authors.forename: Kaiming
authors.initials: K
authors.lastname: Li
authors.forename: Benson H Y
authors.initials: BH
authors.lastname: Yeung
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Gene C W
authors.initials: GC
authors.lastname: Man
authors.forename: Wynnie W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Stephen T C
authors.initials: ST
authors.lastname: Wong
authors.forename: Jack C Y
authors.initials: JC
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009929:Organ Size; D012600:Scoliosis / Q000473:pathology*