Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.
The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.
Roberts
Lindi
L
Division of Pharmacology, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa.
Egan
Timothy J
TJ
Joiner
Keith A
KA
Hoppe
Heinrich C
HC
D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D015153:Blotting, Western; D002738:Chloroquine / Q000494:pharmacology; D004705:Endocytosis / Q000187:drug effects*; D004912:Erythrocytes / Q000469:parasitology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015767:Mefloquine / Q000494:pharmacology; D009195:Peroxidase / Q000378:metabolism; D010616:Phenanthrenes / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D015800:Protozoan Proteins / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*
D000962:Antimalarials; D006454:Hemoglobins; D010616:Phenanthrenes; D015800:Protozoan Proteins; D011804:Quinolines; D000655:Amodiaquine; D002738:Chloroquine; C037219:quinoline; D009195:Peroxidase; C023768:halofantrine; D015767:Mefloquine