Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings.
Sensitivity to an inhibitor of epidermal growth factor receptor (EGFR) kinase strongly correlates with EGFR somatic mutations in non-small cell lung cancer. These mutations are frequently found in patients with adenocarcinoma, never- or light-smokers, women, and East Asians. In this study, we show an aggregation of three non-small cell lung cancer cases with EGFR gene mutations in one family. The subjects were all female, never- or light-smokers with adenocarcinoma. Two of the patients responded to treatment with gefitinib. A genetic study of these cases would be useful in elucidating genetic susceptibility to lung cancer in persons with EGFR mutations.
Sakakibara
Tomohiro
T
Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. sakatomo@idac.tohoku.ac.jp
Saijo
Yasuo
Y
Fukuhara
Tatsuro
T
Gomi
Kazunori
K
Inoue
Akira
A
Ishimoto
Osamu
O
Sugawara
Shunichi
S
Nukiwa
Toshihiro
T
D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D000368:Aged; D001999:Bronchoscopy; D004273:DNA, Neoplasm / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D035781:Siblings; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D004273:DNA, Neoplasm; D066246:ErbB Receptors