Importance of iron and iron metabolism in nonalcoholic fatty liver disease.
Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.
Baptista-Gonzalez
Hector
H
Subdirección de Investigación Clínica, Instituto Nacional de Perinatologia, Mexico City, Mexico.
Chavez-Tapia
Norberto C
NC
Zamora-Valdés
Daniel
D
Uribe
Misael
M
Mendez-Sanchez
Nahum
N
D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000150:complications / Q000378:metabolism
D007501:Iron