Recovery of neuromuscular blockade caused by vecuronium is delayed in patients with hypertriglyceridemia.
We investigated the effects of hypertriglyceridemia on the onset and recovery of neuromuscular blockade, induced by vecuronium, over the adductor pollicis muscle, electromyographically. Eighteen adult patients with hypertriglyceridemia (hypertriglyceridemia group) and 18 healthy patients with normal serum triglyceride (control group) were studied. The supramaximal stimulating current for train-of-four (TOF) in the hypertriglyceridemia group was significantly higher than that in the control group (45.7 +/- 16.7 vs 31.5 +/- 9.8 mA; mean +/- SD; P = 0.004). The onset of vecuronium 0.1 mg.kg(-1)-induced neuromuscular blockade in the hypertriglyceridemia group did not significantly differ from that in the control group (240 +/- 60 vs 279 +/- 88 s; P = 0.132). Times from vecuronium to the return of T1, T2, T3, and T4 in the hypertriglyceridemia group were significantly longer than those in the control group (31.4 +/- 6.2 vs 25.5 +/- 6.2 min for T1; P = 0.008). During recovery from neuromuscular blockade, T1/control did not differ between the two groups. However, the TOF ratios (T4/T1) in the hypertriglyceridemia group were significantly lower than those in the control group 80-120 min after vecuronium (P < 0.05). We conclude that, in patients with hypertriglycemidemia, a higher current is needed to elicit supramaximal response of the adductor pollicis muscle, and recovery from vecuronium-induced neuromuscular blockade is delayed.
Saitoh
Yuhji
Y
Department of Anesthesiology, Satte General Hospital, Satte, Saitama, Japan.
Oshima
Tsutomu
T
Nakata
Yoshinori
Y
D000368:Aged; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D020127:Recovery of Function; D013997:Time Factors; D004561:Transcutaneous Electric Nerve Stimulation; D014673:Vecuronium Bromide / Q000494:pharmacology*
D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide