Integrin-dependent translational control: Implication in cancer progression.
The importance of translational control in cancer progression has been underscored by a number of recent studies. However, little is known how cancer cells maintain their high efficiency of translation. Here, we summarize studies that support the role of integrins in translational control, especially at the initiation step, and discuss the various mechanisms by which integrins regulate the recruitment of translational machinery. This review also examines the hypothesis that integrins contribute to various aspects of cancer progression such as proliferation, survival, angiogenesis, and invasion through translational control.
Chung
Jun
J
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. jchung@lsuhsc.edu
Kim
Tae Hyong
TH
D018450:Disease Progression; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D009385:Neoplastic Processes; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis
D015852:Eukaryotic Initiation Factor-2; D039561:Eukaryotic Initiation Factor-4E; D005353:Fibronectins; D016023:Integrins