[Influence of H2O2 on degradation of residual pesticides and constituents in Radix Sophorae Flavescentis].
OBJECTIVE
To investigate the characteristic and influential factors of the degradation of residual pesticides and alkaloids in Radix Sophorae Flavescentis by H2O2.


METHODS
The spiked samples were treated in H2O2 in different reaction time, concentration and pH value. The pesticide residuals were determined by GC-MS, and the contents of alkaloids were determined by HPLC.


RESULTS
H2O2 had highly activity in degrading organophosphorus and pyrethroid, but had less activity to organochlorines. The degradation processes of organophosphorus and pyrethroid followed first-order kinetics equations, and were influenced by the pH value, the concentration of H2O2 and reaction time. The contents of alkaloids in Radix Sophorae Flavescentis changed not obviously after treatment with 3 mL x L(-1) H2O2 less than 6 hours under neutral condition.


CONCLUSIONS
H2O2 is a useful reagent for the degradation of organophosphorus and pyrethroid in crude drug.
Fu
Xiao-Yan
XY
Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Luan
Lian-Jun
LJ
Zhu
Wei
W
Wu
Yong-Jiang
YJ
D000470:Alkaloids / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D009946:Organothiophosphorus Compounds / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D010573:Pesticide Residues / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011722:Pyrethrins / Q000737:chemistry; D011807:Quinolizines / Q000032:analysis; D029909:Sophora / Q000737:chemistry*; D000093842:Matrines
D000470:Alkaloids; D009946:Organothiophosphorus Compounds; D010573:Pesticide Residues; D011722:Pyrethrins; D011807:Quinolizines; C037573:oxymatrine; D006861:Hydrogen Peroxide; D000093842:Matrines