title: Quality of life in patients with chronic obstructive pulmonary disease: the predictive validity of the BODE index.
abstract: BACKGROUND
  Chronic obstructive pulmonary disease (COPD) is currently the fourth cause of mortality and morbility in the developed world. Patients with COPD experience a progressive deterioration of health-related quality of life (HRQOL). A new model of severity classification, the body mass index, bronchial obstruction, dyspnoea, exercise (BODE) index, has recently been proposed.
  
  
  OBJECTIVE
  To evaluate the relationship between HRQOL and the BODE index, and the predictive ability of BODE on HRQOL measurements.
  
  
  METHODS
  Two HRQOL questionnaires were administered, namely the Nottingham Health Profile (NHP) and St George's Respiratory Questionnaire (SGRQ), in a sample of 67 patients with severe COPD.
  
  
  RESULTS
  Pearsonś correlation coefficient analysis shows a positive correlation between the BODE index and the total scores of the specific (P < 0.001), and general HRQOL (P < 0.001); the analysis shows a significant correlation between the BODE index and the subscales of symptoms, activity and impact of SGRQ (P < 0.001) and the subscales energy and physical mobility of the NHP (P < 0.001). The regression analysis shows that the BODE index is a significant predictor of HRQOL, explaining 46,1% of the total score of the SGRQ (P < 0.001) and 14.8% of the total score of the NHP (P < 0.001).
  
  
  CONCLUSIONS
  The BODE index is good at predicting the worsening of HRQOL in patients with severe COPD.
authors.affiliation: Department of Psychology, Joan March Hospital, Bunyola, Baleares, Spain. mmapsi@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Medinas-Amorós
authors.forename: C
authors.initials: C
authors.lastname: Alorda
authors.forename: F
authors.initials: F
authors.lastname: Renom
authors.forename: M
authors.initials: M
authors.lastname: Rubí
authors.forename: J
authors.initials: J
authors.lastname: Centeno
authors.forename: V
authors.initials: V
authors.lastname: Ferrer
authors.forename: T
authors.initials: T
authors.lastname: Gorriz
authors.forename: C
authors.initials: C
authors.lastname: Mas-Tous
authors.forename: F
authors.initials: F
authors.lastname: Ramis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005080:Exercise Test; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000534:rehabilitation; D011788:Quality of Life; D012044:Regression Analysis; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires