title: Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes.
abstract: OBJECTIVE
  To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes.
  
  
  METHODS
  We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects.
  
  
  RESULTS
  Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders.
  
  
  CONCLUSIONS
  Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.
authors.affiliation: Faculty of Medicine, University of Glasgow, Glasgow, UK. s.nelson@clinmed.gla.ac.uk
authors.forename: Scott M
authors.initials: SM
authors.lastname: Nelson
authors.forename: Dilys J
authors.initials: DJ
authors.lastname: Freeman
authors.forename: Naveed
authors.initials: N
authors.lastname: Sattar
authors.forename: Robert S
authors.initials: RS
authors.lastname: Lindsay
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001724:Birth Weight; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D047109:Fetal Development; D020567:Fetal Weight / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology
chemical_list: D052242:Adiponectin; D007328:Insulin; D020738:Leptin; D007334:Insulin-Like Growth Factor I