title: Complete response of CNS-involved olfactory neuroendocrine tumor using multimodal therapy.
abstract: BACKGROUND
  Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable.
  
  
  METHODS
  We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery.
  
  
  CONCLUSIONS
  To our knowledge, this combination treatment approach has not been reported in the literature.
authors.affiliation: Department of Medicine, The University of Illinois at Chicago, IL 60612, USA.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Ahuja
authors.forename: Sandra
authors.initials: S
authors.lastname: Cuellar
authors.forename: Iffat
authors.initials: I
authors.lastname: Choudhry
authors.forename: Suman
authors.initials: S
authors.lastname: Setty
authors.forename: Mike
authors.initials: M
authors.lastname: Yao
authors.forename: J Lee
authors.initials: JL
authors.lastname: Villano
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000628:therapy*; D002166:Camptothecin / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D005004:Ethmoid Bone / Q000473:pathology*; D006801:Humans; D000077146:Irinotecan; D008297:Male; D018358:Neuroendocrine Tumors / Q000628:therapy*; D009934:Organization and Administration; D018714:Radiotherapy, Adjuvant; D012888:Skull Neoplasms / Q000628:therapy*
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin