title: [Sepsis therapy: present guidelines and their application].
abstract: Severe sepsis and septic shock have an increasing incidence and unchanged high mortality. Early diagnosis is necessary to slow the progression of organ dysfunction and improve outcome. Early administration of broad-spectrum antimicrobial therapy, early and aggressive hemodynamic therapy, and surgical source control are the most promising therapeutic approaches. Norepinephrine is the first choice as a vasopressor. Starches for volume resuscitation, intensive insulin therapy (aiming at 80-110 mg/dl), and low-dose hydrocortisone are not recommended outside randomized trials. Recombinant activated protein C is one choice for certain patients. The German Sepsis Competence Network (SepNet) is currently investigating other open questions.
authors.affiliation: Klinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Jena der Friedrich-Schiller-Universität, Jena, Germany. frank.brunkhorst@med.uni-jena.de
authors.forename: F M
authors.initials: FM
authors.lastname: Brunkhorst
authors.forename: K
authors.initials: K
authors.lastname: Reinhart
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods; D019317:Evidence-Based Medicine; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012772:Shock, Septic / Q000209:etiology / Q000628:therapy*; D013530:Surgical Wound Infection / Q000209:etiology / Q000628:therapy*; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents