title: [Melanoma in invisible naevus spilus].
abstract: BACKGROUND
  Diagnosis of naevus lesions may be complex where they contain little or no pigmentation. Naevus spilus (or naevus on naevus) is, generally, readily identified by the difference in pigmentation between overlying and underlying naevi and healthy skin. Malignant transformation of naevus spilus is rare. We report two cases of melanoma in which surgical procedures revealed underlying melanocyte lesions, diagnosed at histology but undetectable on clinical examination.
  
  
  METHODS
  Two patients were operated for melanoma in which surgery, at a site remote from the melanoma, suggested incomplete relapse despite the fact that previous clinical examination had indicated healthy skin. A diagnosis was made of melanoma in invisible naevus spilus.
  
  
  CONCLUSIONS
  Diagnosis of melanoma in invisible naevus spilus may be suspected where several naevi are found together in a specific area. The main problem is the therapeutic stance to be adopted since complete excision of the underlying naevi is difficult in practice. Wood's light examination may be helpful.
authors.affiliation: Service de dermatologie, hôpital Bichat, université Denis-Diderot Paris-7, Assistance publique-Hôpitaux de Paris, 46, rue Henri-Huchard, 75018 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Livory
authors.forename: V
authors.initials: V
authors.lastname: Descamps
authors.forename: F
authors.initials: F
authors.lastname: Pelletier
authors.forename: E
authors.initials: E
authors.lastname: Maubec
authors.forename: B
authors.initials: B
authors.lastname: Faivre
authors.forename: E
authors.initials: E
authors.lastname: Marinho
authors.forename: P
authors.initials: P
authors.lastname: Humbert
authors.forename: B
authors.initials: B
authors.lastname: Crickx
authors.forename: F
authors.initials: F
authors.lastname: Aubin
mesh_terms: D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009508:Nevus, Pigmented / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery