title: Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease.
abstract: Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a systemic disease that is associated with increased serum levels of markers of systemic inflammation. The triggering receptor expressed on myeloid cells 1 (TREM-1) is a recently identified activating receptor on neutrophils, monocytes, and macrophage subsets. TREM-1 expression is upregulated by microbial products such as the toll-like receptor ligand lipoteichoic acid of Gram-positive or lipopolysaccharides of Gram-negative bacteria. In the present study, sera from 12 COPD patients (GOLD stages I-IV, FEV1 51 +/- 6%) and 10 healthy individuals were retrospectively analyzed for soluble TREM-1 (sTREM-1) using a newly developed ELISA. In healthy subjects, sTREM-1 levels were low (median 0.25 ng/mL, range 0-5.9 ng/mL). In contrast, levels of sTREM-1 in sera of COPD patients were significantly increased (median 11.68 ng/mL, range 6.2-41.9 ng/mL, P<.05). Furthermore, serum levels of sTREM-1 showed a significant negative correlation with lung function impairment. In summary, serum concentrations of sTREM-1 are increased in patients with COPD. Prospective studies are warranted to evaluate the relevance of sTREM-1 as a potential marker of the disease in patients with COPD.
authors.affiliation: Institute of Immunology, University of Mainz, Obere Zahlbacher Street 67, 55131 Mainz, Germany. radsak@uni-mainz.de
authors.forename: Markus P
authors.initials: MP
authors.lastname: Radsak
authors.forename: Christian
authors.initials: C
authors.lastname: Taube
authors.forename: Philipp
authors.initials: P
authors.lastname: Haselmayer
authors.forename: Stefan
authors.initials: S
authors.lastname: Tenzer
authors.forename: Helmut R
authors.initials: HR
authors.lastname: Salih
authors.forename: Rainer
authors.initials: R
authors.lastname: Wiewrodt
authors.forename: Roland
authors.initials: R
authors.lastname: Buhl
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Schild
mesh_terms: D015415:Biomarkers / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008562:Membrane Glycoproteins / Q000097:blood* / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D011971:Receptors, Immunologic / Q000097:blood*; D011994:Recombinant Proteins / Q000097:blood / Q000378:metabolism; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D014162:Transfection; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D011994:Recombinant Proteins; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1