title: Triterpenoidal saponins from Hydrocotyle sibthorpioides.
abstract: Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques ((13)C, (1)H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.
authors.affiliation: National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, ROC.
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Hsi-Uo
authors.initials: HU
authors.lastname: Ho
authors.forename: Li-Ming Yang
authors.initials: LM
authors.lastname: Kuo
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; D009828:Oleanolic Acid