Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection.
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
Yang
Jaemoon
J
Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong Seodaemoon-ku, Seoul, Republic of Korea.
Lim
Eun-Kyung
EK
Lee
Hong Jae
HJ
Park
Joseph
J
Lee
Sang Cheon
SC
Lee
Kwangyeol
K
Yoon
Ho-Geun
HG
Suh
Jin-Suck
JS
Huh
Yong-Min
YM
Haam
Seungjoo
S
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D045744:Cell Line, Tumor; D000068818:Cetuximab; D004847:Epithelial Cells / Q000473:pathology*; D066246:ErbB Receptors; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D006801:Humans; D008279:Magnetic Resonance Imaging; D008856:Microscopy, Fluorescence; D053758:Nanoparticles; D011091:Polyesters / Q000138:chemical synthesis; D011109:Polymethacrylic Acids / Q000138:chemical synthesis; D011721:Pyrenes / Q000138:chemical synthesis
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005456:Fluorescent Dyes; D011091:Polyesters; D011109:Polymethacrylic Acids; D011721:Pyrenes; C016240:polycaprolactone; D066246:ErbB Receptors; D000068818:Cetuximab