[Clinical value of the local parameters of lipid peroxidation and antioxidative defense in patients after cataract extraction].
The postoperative period of cataract extraction and the parameters of lipid peroxidation (LPO) (dienic conjugates, TBA-active compounds) and the antioxidative activity (AOA) of tear were studied in 77 patients in relation to the type of a surgical intervention--extracapsular cataract extraction (ECCE) and phacoemulsification (PE). The incidence of severe postoperative uveitis was more than 3 times higher on days both 1 and 5 after surgery. Tear studies revealed a significant increase in the concentration of LPO products just on day 1, with its further slight increase by day 5 along with a further significant reduction in AOA, which indicates the significant consumption of antioxidative defense components and the expediency of using antioxidants. Comparison of tear biochemical parameters revealed no difference in patients after ECCE and PE. Thus, peroxidation processes reflect the severity of an inflammatory reaction in the early postoperative period, the study of the processes in tear is a noninvasive, high-informative method for recording the balance of LPO and antioxidative defense processes, which will assist in determining the direction of therapeutic measures to improve the outcome of a surgical intervention.
Pikuza
A Kh
AKh
Kuznetsova
M V
MV
Ziganshina
L E
LE
Valeeva
I Kh
IKh
D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D002386:Cataract / Q000378:metabolism*; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D015994:Incidence; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011184:Postoperative Period; D013666:Tears / Q000378:metabolism*; D014605:Uveitis / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*
D000975:Antioxidants