title: [Concordance between hepatitis C virus serotype and genotype in chronic hepatitis C patients in China].
abstract: OBJECTIVE
  To investigate the relationship of hepatitis C virus (HCV) serotype with genotype.
  
  
  METHODS
  The serotypes of HCV in the serum of 104 patients with chronic hepatitis C from 14 cities in China for which HCV genotypes were available, were determined by ELISA using Murex HCV Serotyping 1-6 Assay.
  
  
  RESULTS
  The serotypes of 86 (82.69 percent) of the 104 serum specimens were determined, and HCV serotypes were determined for 91 strains. Overall the concordance between hepatitis C virus serotype and genotype was 62.1 percent, and the concordance of serotype, with genotypes 1, 2 and 3 were 69.4 percent, 51.2 percent and 70.0 percent, respectively. The false-negative rate and concordance of genotype 2b was lower (54.5 percent).
  
  
  CONCLUSIONS
  The specificity of HCV serotyping was affected by HCV strains' genotype and sometimes HCV serotype was not in concordance with genotype.
authors.affiliation: Clinical Laboratory, Beijing Ditan Hospital, Beijing 100011, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Ming-hui
authors.initials: MH
authors.lastname: Li
authors.forename: Yao
authors.initials: Y
authors.lastname: Xie
authors.forename: Shao-cai
authors.initials: SC
authors.lastname: Du
authors.forename: Dao-zhen
authors.initials: DZ
authors.lastname: Xu
mesh_terms: D005838:Genotype; D016174:Hepacivirus / Q000145:classification*; D019698:Hepatitis C, Chronic / Q000821:virology*; D006801:Humans; D012703:Serotyping