Seizures in multiple sclerosis.
Seizures have long been recognized to be part of the disease spectrum of multiple sclerosis (MS). While they occur in only a minority of patients with MS, epileptic seizures can have serious consequences. The treatment of MS can be epileptogenic, and antiepileptic treatment can conversely worsen the symptoms of MS. In this article we present an overview of the current literature on the epidemiology, clinical presentation, pathology, imaging, prognosis and treatment of epileptic seizures in MS.
Koch
Marcus
M
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.w.koch@neuro.umcg.nl
Uyttenboogaart
Maarten
M
Polman
Susan
S
De Keyser
Jacques
J
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D015331:Cohort Studies; D015897:Comorbidity; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D011379:Prognosis; D012008:Recurrence; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants