Characterization of canine platelet activation induced by platelet activating factor (PAF).
Characteristics of the signal transduction in Platelet activating factor (PAF)-activated platelets and effects of anti-platelet agents on this response were investigated in vitro for potential therapeutic applications in canine endotoxemia. Blockade of the PAF receptor by a specific blocker has the strongest inhibitive effect on the PAF-induced platelet reactions. The response was also inhibited by either Ca(2+) channel blockers or prostaglandin E(1).
Tsuchiya
Ryo
R
School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan. tsutiyar@azabu-u.ac.jp
Tatsuki
Yumiko
Y
Kitao
Satoshi
S
Furuichi
Mitsuru
M
Neo
Sakurako
S
Hisasue
Masaharu
M
Yamada
Takatsugu
T
Kobayashi
Kosaku
K
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium; D003094:Collagen; D004285:Dogs; D010972:Platelet Activating Factor / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects*; D013449:Sulfonamides / Q000494:pharmacology
D010972:Platelet Activating Factor; D013449:Sulfonamides; D000244:Adenosine Diphosphate; C017967:W 7; D003094:Collagen; D002118:Calcium