title: HPLC as a tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids.
abstract: HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.
authors.affiliation: Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, 541 24 Greece. samanidu@chem.auth.gr
authors.forename: V F
authors.initials: VF
authors.lastname: Samanidou
authors.forename: M K
authors.initials: MK
authors.lastname: Nika
authors.forename: I N
authors.initials: IN
authors.lastname: Papadoyannis
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans
chemical_list: D000929:Antidepressive Agents, Tricyclic