Signaling to nuclear transport.
In a recent issue of Molecular Cell, Yoon et al. provide evidence for the control of nucleocytoplasmic transport by protein kinase signaling pathways through phosphorylation of RanBP3, an accessory factor in the Ran GTPase system. This mechanism may coordinate nucleocytoplasmic transport with other mitogenic effects of these pathways.
Clarke
Paul R
PR
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom. p.r.clarke@dundee.ac.uk
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D029543:Nucleocytoplasmic Transport Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D020931:ran GTP-Binding Protein / Q000378:metabolism
D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; C120587:RAN protein, human; C112820:RANBP3 protein, human; D020931:ran GTP-Binding Protein