[Exploration of quality control of inorganic elements in Chinese herbal medicines for stimulating blood circulation and relaxing muscles and joints by atomic absorption spectrophotometry].
Researches have shown the close relationships between inorganic elements and curative efficiencies of various Chinese herbal medicines. Yet, in studies of chemical composition and quality control of Chinese herbal medicines for stimulating blood circulation and relaxing muscles and joints, inorganic substances are often overlooked. In order to improve and reestablish the standard of quality control of Chinese herbal medicines, the authors attempted a method that would incorporate the composition of inorganic elements as part of the quality control. In the present study, the authors used atomic absorption spectrophotometry to measure the contents of fifteen inorganic elements, namely, Cu, Ca, Fe, K, Mg, Mo, Ni, Sr, V, Mn, Zn, Na, Cr, Cd, and Hg, in several Chinese herbal medicines, including Da Huo Luo Wan. The authors then discussed the relationship between these inorganic elements and curative efficiencies of these Chinese herbal medicines. By comparing the levels of inorganic elements found in Da Huo Luo Wan with those found in other Chinese herbal medicines used in the study, it was revealed that trace elements, Fe, Cu, Mn, and Zn, contribute to the curative efficiency of Da Huo Luo Wan. The authors' results showed that the amounts of trace elements Fe, Cu, Mn and Zn found in Chinese herbal medicine Da Huo Luo Wan are related to the following curative effects of Da Huo Luo Wan: relieving rheumatism, rectifying breathing and alleviating phlegm, stimulating blood circulation and relaxing muscles and joints. The measurement and analysis of inorganic elements in Da Huo Luo Wan will also provide evidences and references for the fingerprint establishment of Da Huo Luo Wan in the future.
Zhang
Qi-feng
QF
Institute of Applied Chemistry, Nanchang University, Nanchang 330047, China. zqf@ncu.edu.cn
Fan
Mei-mei
MM
Wang
Guan-min
GM
Tu
Long-fei
LF
Wang
Cheng
C
D004365:Drugs, Chinese Herbal / Q000032:analysis*; D006401:Hematologic Agents / Q000032:analysis*; D009125:Muscle Relaxants, Central / Q000032:analysis*; D011786:Quality Control; D013054:Spectrophotometry, Atomic / Q000379:methods*; D014131:Trace Elements / Q000032:analysis*
D004365:Drugs, Chinese Herbal; D006401:Hematologic Agents; D009125:Muscle Relaxants, Central; D014131:Trace Elements