[Molecular mechanisms for intracellular parasitisation and exclusion in macrophage infected with Mycobacterium leprae].
It was previously demonstrated that TLR2 and CORO1A (TACO, Coronin 1, p57) localize phagosome membrane of macrophage. However, the functional relationship between TLR2 and CORO1A was not known. We show here that there is a functional counteraction between TLR2 and CORO1A.
Tanigawa
Kazunari
K
Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan. tanigawa@nih.go.jp
Suzuki
Koichi
K
Kawashima
Akira
A
Mishima
Masayo
M
Wu
Huhehasi
H
Akama
Takeshi
T
Takeshita
Fumihiko
F
Ishii
Norihisa
N
D002478:Cells, Cultured; D006801:Humans; D007918:Leprosy / Q000235:genetics / Q000382:microbiology; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*; D008840:Microfilament Proteins / Q000502:physiology*; D009166:Mycobacterium leprae; D010588:Phagosomes / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology; D012867:Skin / Q000166:cytology; D051195:Toll-Like Receptor 2 / Q000502:physiology*
D008840:Microfilament Proteins; D051195:Toll-Like Receptor 2; C072061:coronin proteins