Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst.
A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.
Kano
Taichi
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Ueda
Mitsuhiro
M
Maruoka
Keiji
K
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013237:Stereoisomerism; D013388:Succinimides / Q000737:chemistry*
D000447:Aldehydes; D000605:Amino Alcohols; D013388:Succinimides; C008155:N-iodosuccinimide