title: Clinicopathological factors related to cervical lymph node metastasis in a patient with carcinoma of the oral floor.
abstract: CONCLUSIONS
  Tumors developing into the muscle layer and tumor thickness > or =5 mm are the most important risk factors associated with nodal metastasis.
  
  
  OBJECTIVE
  It is necessary to identify the risk factors associated with cervical metastasis in patients with oral floor cancer to reveal the role of elective neck dissection for oral floor cancer.
  
  
  METHODS
  Forty-eight patients with oral floor cancer were retrospectively analyzed for a correlation between clinicopathologic factors and cervical lymph node metastasis using Fisher's exact test and a logistic regression test.
  
  
  RESULTS
  Univariate analysis showed significantly positive correlations for growth type, mitosis, perineural invasion, vascular invasion, lymphatic invasion, depth, thickness, and infiltration growth ratio. Multivariate analysis had a significantly positive correlation with nest formation and depth in all patients, and with thickness in patients with T1 or T2. In patients with bilateral cervical lymph node metastasis, lymph node metastasis was significantly positively correlated with perineural invasion.
authors.affiliation: Department of Otolaryngology, Tokyo Metropolitan Police Hospital, 2-10-41 Fujimi, Chiyoda-ku, Tokyo, Japan. misuzuki-tky@umin.ac.jp
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Suzuki
authors.forename: Tsunemiti
authors.initials: T
authors.lastname: Suzuki
authors.forename: Masao
authors.initials: M
authors.lastname: Asai
authors.forename: Kei-Ichi
authors.initials: K
authors.lastname: Ichimura
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nibu
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugasawa
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Kaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006258:Head and Neck Neoplasms / Q000556:secondary* / Q000601:surgery*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery*; D037981:Neck Dissection; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome