title: Glycosidic constituents of the tubers of Gymnadenia conopsea.
abstract: Ten minor new glycosidic constituents (1- 10), together with 10 known compounds, have been isolated from a neuroprotective fraction of an ethanolic extract of the tubers of Gymnadenia conopsea. The structures of 1-10 were determined using spectroscopic and chemical methods. The compounds isolated were evaluated for activity in in vitro assays for acetylcholine esterase and monoamine oxidase inhibitory activities.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zi
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Mingtao
authors.initials: M
authors.lastname: Liu
authors.forename: Maoluo
authors.initials: M
authors.lastname: Gan
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Weixia
authors.initials: W
authors.lastname: Song
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Fan
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
authors.forename: Duolong
authors.initials: D
authors.lastname: Di
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*; D035281:Plant Tubers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D008996:Monoamine Oxidase Inhibitors