title: The contribution of intrapulmonary shunts to the alveolar-to-arterial oxygen difference during exercise is very small.
abstract: Exercise is well known to cause arterial PO2 to fall and the alveolar-arterial PO2 difference(Aa PO2 ) to increase. Until recently, the physiological basis for this was considered to be mostly ventilation/perfusion ((.)VA/(.)Q) inequality and alveolar-capillary diffusion limitation. Recently, arterio-venous shunting through dilated pulmonary blood vessels has been proposed to explain a significant part of the Aa PO2 during exercise. To test this hypothesis we determined venous admixture during 5 min of near-maximal, constant-load, exercise in hypoxia (in inspired O2 fraction, FIO2 , 0.13), normoxia (FIO2 , 0.21) and hyperoxia (FIO2 , 1.0) undertaken in balanced order on the same day in seven fit cyclists ((.)VO2max, 61.3 +/- 2.4 ml kg(-1) min(-1); mean +/- S.E.M.). Venous admixture reflects three causes of hypoxaemia combined: true shunt, diffusion limitation and ((.)VA/(.)Q) inequality. In hypoxia, venous admixture was 22.8 +/- 2.5% of the cardiac output; in normoxia it was 3.5 +/- 0.5%; in hyperoxia it was 0.5 +/- 0.2%. Since only true shunt accounts for venous admixture while breathing 100% O2, the present study suggests that shunt accounts for only a very small portion of the observed venous admixture, Aa PO2 and hypoxaemia during heavy exercise.
authors.affiliation: Medical School of Athens University, Department of Critical Care and Pulmonary Services, Evangelismos Hospital, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vogiatzis
authors.forename: Spyros
authors.initials: S
authors.lastname: Zakynthinos
authors.forename: Robert
authors.initials: R
authors.lastname: Boushel
authors.forename: Dimitris
authors.initials: D
authors.lastname: Athanasopoulos
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Guenette
authors.forename: Harrieth
authors.initials: H
authors.lastname: Wagner
authors.forename: Charis
authors.initials: C
authors.lastname: Roussos
authors.forename: Peter D
authors.initials: PD
authors.lastname: Wagner
mesh_terms: D010100:Oxygen / Q000378:metabolism*; D010807:Physical Endurance / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000502:physiology*; D011651:Pulmonary Artery / Q000502:physiology*; D011659:Pulmonary Gas Exchange / Q000502:physiology*
chemical_list: D010100:Oxygen