R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.
Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted to replicate this result in 9714 French Caucasian individuals, combining family-based and general population studies. We confirmed an association with familial obesity (defined as body mass index (BMI) > or = 97th percentile) in women from 1109 obesity-selected pedigrees (Z-score = 2.70, P = 0.008). Analysis of 16 microsatellite markers on chromosome 4 restricted to the 42 pedigrees carrying the TBC1D1 R125W variant allele also revealed a suggestive evidence of linkage with obesity (maximum likelihood binomial LOD of 2.73, P = 0.0002) on chromosome 4p14, where resides TBC1D1. In contrast, R125W variant was neither associated with BMI nor with obesity in a large population-based cohort. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.
Meyre
David
D
CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
Farge
Morgane
M
Lecoeur
Cécile
C
Proenca
Christine
C
Durand
Emmanuelle
E
Allegaert
Frédéric
F
Tichet
Jean
J
Marre
Michel
M
Balkau
Beverley
B
Weill
Jacques
J
Delplanque
Jérôme
J
Froguel
Philippe
P
D000328:Adult; D002648:Child; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005602:France; D020690:GTPase-Activating Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
D020690:GTPase-Activating Proteins; C526441:TBC1D1 protein, human