title: Synthesis of novel derivatives of bispodophyllotoxin as potential antineoplastic agents--part XVI.
abstract: Podophyllotoxin and related analogs present numerous challenges associated with optimal antitumor activity and severe unpredictable toxicity. In an attempt to find biorational podophyllotoxin-related drug, two moieties of podophyllotoxin have been linked at C4-position by a simple modification of the carbodiimide procedure to provide novel bispodophyllotoxin analogs (4a-4e) and their structural information was extensively characterized by using 1H-NMR, IR, and HRMS.
authors.affiliation: School of Pharmacy, Lanzhou University, Lanzhou, PR China. yqliu@lzu.edu.cn
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Liu
authors.forename: Ying-Qi
authors.initials: YQ
authors.lastname: Liu
authors.forename: Xuan
authors.initials: X
authors.lastname: Tian
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011034:Podophyllotoxin