title: Serum S-100B protein levels in left- and right-hemisphere strokes.
abstract: S-100B is a calcium-binding protein that is expressed in astrocytes. We compared the kinetics of serum S-100B in left- and right-hemisphere strokes. Data from 38 acute ischaemic stroke patients who had serial serum S-100B measurements during the first 8 days were analyzed. Stroke severity at baseline, as assessed by the National Institutes of Health Stroke Scale (NIHSS), was similar in the two groups. Mean S-100B values were greater in the right-hemisphere stroke group at all time points. Maximum S-100B levels were low in all patients with lower baseline NIHSS scores, and began to rise at a baseline NIHSS score of 16 for right-hemisphere stroke and 20 for left-hemisphere stroke. S-100B levels were significantly correlated with language in left-hemisphere stroke and with neglect in right-hemisphere stroke. These results are consistent with previous clinical/radiological findings, suggesting that serum S-100B is brain-specific and reflects the extent of brain injury in acute ischaemic stroke.
authors.affiliation: Ono Pharma USA, Inc., 2000 Lenox Drive, Lawrenceville, New Jersey 08648, USA. hideyasu.ishibashi@ono-usa.com
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Funakoshi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D010468:Perceptual Disorders / Q000209:etiology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood* / Q000150:complications; D013997:Time Factors
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins