PET imaging with 11C-acetate in prostate cancer: a biochemical, radiochemical and clinical perspective.
OBJECTIVE
In the present study, the potential clinical role of 11C-acetate PET mainly in the differential diagnosis, in the staging and in the follow-up of prostate cancer patients is reported.


METHODS
Each of the above points has been accurately investigated by studying the specific biochemical and radiobiochemical behaviour of this positron emitter compound.


CONCLUSIONS
The imaging quality of 11C-acetate PET and its unique mechanisms of cellular uptake, make such radiotracer a powerful tool in evaluating all the steps of the prostatic cancer.
Soloviev
Dmitri
D
Wolfson Brain Imaging Centre Department, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Fini
Alberto
A
Chierichetti
Franca
F
Al-Nahhas
Adil
A
Rubello
Domenico
D
D000085:Acetates; D002244:Carbon; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000085:Acetates; D019275:Radiopharmaceuticals; C438206:carbon-11 acetate; D002244:Carbon