title: [Efficacy of adipin and normodipin (generic drugs of amlodipine) vs norvsc in treatment of essential hypertension].
abstract: It's well known, that norvsc - a very effective and popular cardiovascular medication - has many generic analogs. The reason of our study was to compare the efficacy and safety of adipin ("GMP", Georgia), normodipin ("Gedeon Richter", Hungary) and norvasc ("Pfizer", USA) in patients with essential hypertension (stage I-II, JNC VII). The study was performed using ambulatory blood pressure monitoring (ABPM), the data from which closely correlate with end-organ damage in hypertension and provides excellent information about hypotensive drug effect on the circadian rhythm of blood pressure and its adequate control. It was open liable, crossover, comparative, prospective trial in 20 patients. Our data confirm that generic drugs adipin and normodipine are as effective and safe as original norvasc in treatment of patients with hypertension.
authors.affiliation: M. Tsinamdzgvrishvili Research Institute of Cardiology, Georgian Society of Hypertension, Georgia.
authors.forename: B
authors.initials: B
authors.lastname: Tsinamdzgvrishvili
authors.forename: D
authors.initials: D
authors.lastname: Trapaidze
authors.forename: N
authors.initials: N
authors.lastname: Loladze
authors.forename: A
authors.initials: A
authors.lastname: Rekhviashvili
mesh_terms: D017311:Amlodipine / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D018592:Cross-Over Studies; D016568:Drugs, Generic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers; D016568:Drugs, Generic; D017311:Amlodipine