In vivo and in vitro production options for fungal secondary metabolites.
Microbial natural products, among them a vast diversity of fungal origin, represent a major source for new drug candidates. Focusing on fungal metabolites, our review covers recent advances in the field of biotransformation, heterologous expression, in vivo production approaches, genomics, and the metabolism of unexplored fungal groups as options to generate and identify new compounds or optimize known ones.
Schneider
Patrick
P
Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-Universität, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany.
Misiek
Mathias
M
Hoffmeister
Dirk
D
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001688:Biological Products / Q000096:biosynthesis*; D001711:Biotransformation; D005658:Fungi / Q000378:metabolism*; D023281:Genomics
D000900:Anti-Bacterial Agents; D001688:Biological Products