No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements.
OBJECTIVE
Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings.


METHODS
Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type 1 patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated.


RESULTS
Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72.


CONCLUSIONS
Microdialysis CGM can be accurately performed in the proximity of CSII systems.
Hermanides
Jeroen
J
Academic Medical Center, Amsterdam, the Netherlands. j.hermanides@amc.uva.nl
Wentholt
Iris M
IM
Hart
Augustinus A
AA
Hoekstra
Joost B
JB
DeVries
J Hans
JH
D000328:Adult; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007258:Informed Consent; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D018579:Patient Selection; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin