title: Mutational analysis of ABC proteins.
abstract: The 49 human members of the ATP-binding cassette (ABC) family of proteins are involved in a wide range of activities such as active transport of compounds across membranes, extraction of compounds out of membranes, functioning as ion channels, or regulators of channel activity. Mutations and/or overexpression of many of the proteins can have adverse effects on health. A goal in the study of ABC proteins is to understand their mechanisms of action. This review will focus on the mutational approaches that have been used to study the structure and mechanisms of some ABC proteins.
authors.affiliation: Department of Medicine, University of Toronto, 1 King's College Circle, Rm. 7342, Medical Sciences Building, Toronto, Ont., Canada.
authors.forename: Tip W
authors.initials: TW
authors.lastname: Loo
authors.forename: David M
authors.initials: DM
authors.lastname: Clarke
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001120:Arginine / Q000235:genetics; D003545:Cysteine / Q000235:genetics; D018432:Drug Resistance, Multiple; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D009154:Mutation; D011487:Protein Conformation; D017384:Sequence Deletion
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D001120:Arginine; D003545:Cysteine; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1