The spectrum of recurrent thoughts and behaviors in frontotemporal dementia.
This article describes the spectrum of recurrent thoughts and behaviors that can result from frontotemporal dementia (FTD) and its variants. Although repetitive behaviors can result from a range of brain disorders, FTD is the most common neurologic cause of new-onset recurrent thoughts and behaviors in middle or late life. Patients with FTD can manifest typical or bizarre compulsions, hoarding, verbal and motor stereotypies and complex tics; self-injurious acts, perseverations; and fixed, obsessional thoughts. The frequency and variability of these repetitive behaviors suggest a common disturbance of orbitofrontal-basal ganglia circuits involved in response inhibition. The amelioration of these recurrent events with the administration of serotonin selective reuptake inhibitors further suggests a serotonergic deficit.
Mendez
Mario F
MF
Department of Neurology, the David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA. mmendez@UCLA.edu
Shapira
Jill S
JS
D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003704:Dementia / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D003987:Dibenzothiazepines / Q000627:therapeutic use; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008559:Memantine / Q000627:therapeutic use; D009483:Neuropsychological Tests; D000069348:Quetiapine Fumarate; D012008:Recurrence; D020280:Sertraline / Q000627:therapeutic use; D019956:Stereotypic Movement Disorder / Q000188:drug therapy / Q000209:etiology; D013850:Thinking / Q000502:physiology*
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D015259:Dopamine Agents; D000069348:Quetiapine Fumarate; D020280:Sertraline; D008559:Memantine