Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients.
Immature or reticulated platelets are known as a clinical marker of thrombopoiesis. Recently, an automatic method was established to detect reticulated platelets as immature platelet fraction (IPF) by means of hematology analyzer XE-2100. We assessed the effects of IPF detection after chemotherapy for various pediatric malignant disorders of 16 patients. Our results indicate that IPF should be considered a useful marker of imminent platelet recovery so that unnecessary platelet transfusion can be avoided.
Saigo
Katsuyasu
K
Blood Transfusion Division, Kobe University Hospital, Chuo-ku, Kobe 650-0017, Japan. saigo@med.kobe-u.ac.jp
Sakota
Yasuyuki
Y
Masuda
Yukako
Y
Matsunaga
Kyoko
K
Takenokuchi
Mariko
M
Nishimura
Kunihiro
K
Sugimoto
Takeshi
T
Sakurai
Kosuke
K
Hashimoto
Makoto
M
Yanai
Tomoko
T
Hayakawa
Akira
A
Takeshima
Yasuhiro
Y
Nomura
Tsutomu
T
Kubota
Yoshitsugu
Y
Kumagai
Shunichi
S
D000293:Adolescent; D001331:Automation; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004867:Equipment Design; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010976:Platelet Count; D017713:Platelet Transfusion / Q000379:methods*; D012016:Reference Values; D033581:Stem Cell Transplantation; D034061:Thrombopoiesis; D013997:Time Factors