Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones.
The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity.
Farrera-Sinfreu
Josep
J
Combinatorial Chemistry Unit, Barcelona Scientific Park (PCB), Josep Samitier 1-5, E-08028 Barcelona, Spain.
Aviñó
Anna
A
Navarro
Isabel
I
Aymamí
Juan
J
Beteta
Natàlia G
NG
Varón
Sònia
S
Pérez-Tomás
Ricardo
R
Castillo-Avila
Wilmar
W
Eritja
Ramon
R
Albericio
Fernando
F
Royo
Miriam
M
D000577:Amides / Q000737:chemistry*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000577:Amides; D000596:Amino Acids; D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D010455:Peptides