title: HPT axis, CSF monoamine metabolites, suicide intent and depression severity in male suicide attempters.
abstract: A lower thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) in depressed women has been associated with violent suicide attempts, suicidal intent, higher lethality and suicide risk. The cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) levels are related to suicidal behaviour. We studied the HPT axis function in twelve male suicide attempters and eight healthy volunteers submitted to lumbar puncture and to TRH test. Suicidal behaviour and depression severity were assessed. There was no association between deltamaxTSH and violent suicidality or subsequent suicide. The deltamaxTSH correlated with CSF HVA in suicide attempters. The plasma T3 showed a negative correlation with the Beck Suicide Intent Scale and the Montgomery Asberg Depression rating scale. Dopaminergic regulatory mechanisms on the thyroid hormone activity may be altered in male suicide attempters.
authors.affiliation: Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden. jussi.jokinen@ki.se
authors.forename: Jussi
authors.initials: J
authors.lastname: Jokinen
authors.forename: Mats
authors.initials: M
authors.lastname: Samuelsson
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Nordström
authors.forename: Peter
authors.initials: P
authors.lastname: Nordström
mesh_terms: D000328:Adult; D035061:Control Groups; D003866:Depressive Disorder / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013129:Spinal Puncture; D013268:Stimulation, Chemical; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data*; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*; D013972:Thyrotropin / Q000097:blood / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D014284:Triiodothyronine / Q000097:blood; D014754:Violence / Q000523:psychology / Q000706:statistics & numerical data
chemical_list: D014284:Triiodothyronine; D006897:Hydroxyindoleacetic Acid; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D006719:Homovanillic Acid