The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma.
BACKGROUND
In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis.


METHODS
An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed.


RESULTS
Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination.


CONCLUSIONS
Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.
Li
Yan
Y
Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Woodall
Charles
C
Wo
John M
JM
Zheng
Huaiyu
H
Ng
Chin K
CK
Ray
Mukunda B
MB
Martin
Robert C
RC
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001471:Barrett Esophagus / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000473:pathology*; D019788:Fluorodeoxyglucose F18; D007150:Immunohistochemistry; D008679:Metaplasia / Q000473:pathology; D049268:Positron-Emission Tomography; D011230:Precancerous Conditions / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
D018809:Proliferating Cell Nuclear Antigen; D019788:Fluorodeoxyglucose F18