The development of drug metabolism research as expressed in the publications of ASPET: Part 2, 1959-1983.
In 25 years, drug metabolism research went from using subcellular particles of undefined content to an understanding of metabolism at the molecular level. The discoveries of cytochrome P450, enzyme induction, reactive intermediates, and genetic polymorphisms were milestones in the field. New publications from the American Society for Pharmacology and Experimental Therapeutics chronicled the discoveries and provided communications to advance the science of drug metabolism.
Murphy
Patrick J
PJ
College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana, USA. pjmurphy12@aol.com
D000818:Animals; D035843:Biomedical Research / Q000266:history*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System; D049673:History, 20th Century; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011642:Publications; D012958:Societies, Scientific
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System