[Anticonvulsant effects of levetiracetam on audiogenic epileptiform siezures in Krushinsky-Molodkina rats].
The new antiepileptic drug levetiracetam (LVT) at doses of 40 and 80 mg/kg exhibits a pronounced anticonvulsant effect, influencing all the parameters of audiogenic epileptiform seizures (AES) in Krushinsky-Molodkina (KM) rats. The latent period of the motor reaction was increased 3-15 times compared to control, and the intensity of single convulsive episodes was significantly decreased. Changes were also detected in the profile of the first stage of motor activity, and the "two-wave" reaction was observed in 50-80% of animals. The mechanism of LVT anticonvulsant action in KM rats is probably associated with an increase in the inhibitory and a decrease in the excitatory processes in the CNS.
Malikova
L A
LA
Fedotova
I B
IB
Poletaeva
I I
II
Raevskiĭ
K S
KS
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D020195:Epilepsy, Reflex / Q000503:physiopathology*; D000077287:Levetiracetam; D008297:Male; D051379:Mice; D010889:Piracetam / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam