title: Correlation between clinical/neurophysiological findings and quality of life in Charcot-Marie-Tooth type 1A.
abstract: Quality of life (QoL), as defined by the Short Form 36, has previously been shown to be abnormal in patients with Charcot-Marie-Tooth disease (CMT), both for Physical Composite Scores (PCS) and Mental Composite Scores (MCS). We have now extended these observations in a multicenter evaluation of 89 patients with Charcot-Marie-Tooth disease type 1A, the most common form of CMT. Both the PCS and MCS were abnormal also in this cohort, compared with the Italian population at large. In particular, the ability to ambulate independently as well as toe and heel walk correlated well with QoL measures in our patients.
authors.affiliation: Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy. lpadua@rm.unicatt.it
authors.forename: Luca
authors.initials: L
authors.lastname: Padua
authors.forename: Michael E
authors.initials: ME
authors.lastname: Shy
authors.forename: Irene
authors.initials: I
authors.lastname: Aprile
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cavallaro
authors.forename: Davide
authors.initials: D
authors.lastname: Pareyson
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
authors.forename: Nicolo
authors.initials: N
authors.lastname: Rizzuto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vita
authors.forename: Pietro
authors.initials: P
authors.lastname: Tonali
authors.forename: Angelo
authors.initials: A
authors.lastname: Schenone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002607:Charcot-Marie-Tooth Disease / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology*; D015331:Cohort Studies; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*