Variation of a variation: case report of attenuated familial adenomatous polyposis.
BACKGROUND
First described in 1988, attenuated familial adenomatous polyposis (AFAP) is a rare autosomal dominant precancerous condition of the gastrointestinal tract. Few reports have described adenocarcinomatous change in the gastroduodenal region thus far.


METHODS
We report a case of AFAP presenting with extensive gastric polyposis and ampullary adenocarcinoma in absence of a positive family history of gastrointestinal cancer and a novel mutation.
Bhatnagar
P
P
Institute of Liver Studies, King's College Hospital, London , UK.
Tetzlaff
H
H
Izatt
L
L
Devlin
J
J
Heaton
N D
ND