title: Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans.
abstract: OBJECTIVE
  Genetic variation in the EPHX2 gene region has been reported to influence susceptibility to ischemic stroke in blacks. We assessed the role of this gene region in white Europeans and performed analyses with regard to stroke subtypes.
  
  
  METHODS
  Twenty-six single nucleotide polymorphisms in the EPHX2 gene region were genotyped in 601 patients with ischemic stroke and 736 matched controls. Cases were subtyped according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system. Analyses were done on single markers and haplotypes using a sliding-window approach.
  
  
  RESULTS
  Three single nucleotide polymorphisms showed associations with an increased risk for ischemic stroke (allelic models; all P<or=0.01). One of them retained statistical significance after correction for multiple testing. Associations were observed with large-vessel stroke and stroke of undetermined etiology but not with other stroke subtypes.
  
  
  CONCLUSIONS
  Our findings confirm and extend previous studies suggesting that genetic variation in or near the EPHX2 gene contributes to the risk of ischemic stroke. This association seems to be mediated predominantly by large-vessel disease.
authors.forename: Andreas
authors.initials: A
authors.lastname: Gschwendtner
authors.forename: Stephan
authors.initials: S
authors.lastname: Ripke
authors.forename: Tobias
authors.initials: T
authors.lastname: Freilinger
authors.forename: Peter
authors.initials: P
authors.lastname: Lichtner
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D004252:DNA Mutational Analysis; D004851:Epoxide Hydrolases / Q000235:genetics*; D005060:Europe / Q000208:ethnology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D020521:Stroke / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D044465:White People
chemical_list: D005819:Genetic Markers; D004851:Epoxide Hydrolases; C506428:EPHX2 protein, human