title: Characterization of canine platelet activation induced by platelet activating factor (PAF).
abstract: Characteristics of the signal transduction in Platelet activating factor (PAF)-activated platelets and effects of anti-platelet agents on this response were investigated in vitro for potential therapeutic applications in canine endotoxemia. Blockade of the PAF receptor by a specific blocker has the strongest inhibitive effect on the PAF-induced platelet reactions. The response was also inhibited by either Ca(2+) channel blockers or prostaglandin E(1).
authors.affiliation: School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan. tsutiyar@azabu-u.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Tsuchiya
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Tatsuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kitao
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Furuichi
authors.forename: Sakurako
authors.initials: S
authors.lastname: Neo
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hisasue
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamada
authors.forename: Kosaku
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium; D003094:Collagen; D004285:Dogs; D010972:Platelet Activating Factor / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects*; D013449:Sulfonamides / Q000494:pharmacology
chemical_list: D010972:Platelet Activating Factor; D013449:Sulfonamides; D000244:Adenosine Diphosphate; C017967:W 7; D003094:Collagen; D002118:Calcium