title: Prognostic significance of serum hepatocyte growth factor in clear cell renal cell carcinoma: comparison with serum vascular endothelial growth factor.
abstract: No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Patients with clear cell RCC had significantly higher serum HGF and VEGF concentrations than healthy subjects: median, 1070.7 versus 728.3 pg/ml (p<0.0001) for HGF; and median, 397.5 versus 245.6 pg/ml (p=0.0003) for VEGF. We found a significant correlation between serum level of HGF and clinical stage and tumor grade. Survival of patients with high serum HGF (>1150 pg/ml) was significantly reduced compared to patients with low serum HGF concentrations (p=0.0044). In patients with nuclear grade 2 or high stage RCC, the higher serum HGF group exhibited significantly lower cause-specific survival (p=0.0087 and p< 0.05, respectively). No significant difference was observed between serum VEGF levels and cause-specific survival rate. Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC.
authors.affiliation: Department of Urology, Takamatsu Red Cross Hospital, Tokushima, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Tanimoto
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Fukumori
authors.forename: Gad
authors.initials: G
authors.lastname: El-Moula
authors.forename: Avirmed
authors.initials: A
authors.lastname: Shiirevnyamba
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kinouchi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Koizumi
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nakanishi
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Taue
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nakatsuji
authors.forename: Tomoteru
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Izaki
authors.forename: Natsuo
authors.initials: N
authors.lastname: Oka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Hiro-Omi
authors.initials: HO
authors.lastname: Kanayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor