title: [Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines].
abstract: To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats. The absorption of the drug conforms to the firt-order kinetics and passive transport mechanism . The results indicate that paeonol-beta-CD absorption mechanism wasn't change.
authors.affiliation: Department of Pharmaceutics, Anhui College of Traditional Chinese Medicine, Hefei 230038, China. hurongfeng@163.com
authors.forename: Rong-Feng
authors.initials: RF
authors.lastname: Hu
authors.forename: Cheng-Wu
authors.initials: CW
authors.lastname: Fang
authors.forename: Ai-Feng
authors.initials: AF
authors.lastname: Zou
authors.forename: Kang-Kang
authors.initials: KK
authors.lastname: Mei
authors.forename: Ji-Hui
authors.initials: JH
authors.lastname: Tang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Han
mesh_terms: D000098:Acetophenones / Q000493:pharmacokinetics*; D000818:Animals; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000098:Acetophenones; C013638:paeonol