Management of occluded uncovered metallic stents in patients with malignant distal biliary obstructions using covered metallic stents.
BACKGROUND
Self-expandable metallic stents (EMSs) have been widely used for the palliative treatment of unresectable malignant biliary obstructions, but EMSs are often occluded owing to tumor ingrowth via the wire mesh. Currently, there is no consensus on the management of occluded EMSs. We evaluated the efficacy of a covered EMS as a second endoprosthesis in patients with an occluded EMS.


METHODS
Forty patients with an occluded uncovered EMS (14 men, 26 women; mean age 72 y, range 41 to 89 y) were studied. The patients suffered from the following: pancreatic cancer in 18, bile duct cancer in 11, gallbladder cancer in 5, lymph node metastasis in 4, and papillary cancer in 2. Of these, 26, 7, and 7 were treated with a covered EMS, an uncovered EMS, and a plastic stent (PS), respectively. The second stent was inserted as a stent-in-stent.


RESULTS
The mean patent period for the covered EMS was 220 days, whereas the mean patent periods for the uncovered EMS and plastic stent were 141 and 58 days, respectively. The cumulative patency of the covered EMS group was significantly higher (P=0.0404) than that of the uncovered EMS group. No significant differences in survival were observed between the covered and uncovered groups. No serious complications occurred.


CONCLUSIONS
Insertion of a covered EMS is an effective and safe treatment for an occluded uncovered EMS.
Togawa
Osamu
O
Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Kawabe
Takao
T
Isayama
Hiroyuki
H
Nakai
Yousuke
Y
Sasaki
Takashi
T
Arizumi
Toshihiko
T
Matsubara
Saburou
S
Ito
Yukiko
Y
Yamamoto
Natsuyo
N
Sasahira
Naoki
N
Hirano
Kenji
K
Tsujino
Takeshi
T
Toda
Nobuo
N
Tada
Minoru
M
Yoshida
Haruhiko
H
Omata
Masao
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D020099:Coated Materials, Biocompatible; D013505:Digestive System Surgical Procedures / Q000379:methods*; D004379:Duodenal Neoplasms / Q000150:complications / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008670:Metals; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis; D011475:Prosthesis Failure; D019919:Prosthesis Implantation / Q000295:instrumentation*; D012086:Reoperation; D012189:Retrospective Studies; D015607:Stents; D015996:Survival Rate; D016896:Treatment Outcome
D020099:Coated Materials, Biocompatible; D008670:Metals