The GTPase CpgA is implicated in the deposition of the peptidoglycan sacculus in Bacillus subtilis.
Depletion of the Bacillus subtilis GTPase CpgA produces abnormal cell shapes, nonuniform deposition of cell wall, and five- to sixfold accumulation of peptidoglycan precursors. Nevertheless, the inherent structure of the cell wall appeared mostly unchanged. The results are consistent with CpgA being involved in coordinating normal peptidoglycan deposition.
Absalon
Cédric
C
Université Paris-Sud 11, Institut de Génétique et Microbiologie, CNRS UMR 8621, Bâtiment 409, 91405 Orsay Cedex, France.
Hamze
Kassem
K
Blanot
Didier
D
Frehel
Claude
C
Carballido-Lopez
Rut
R
Holland
Barry I
BI
van Heijenoort
Jean
J
Séror
Simone J
SJ
D001412:Bacillus subtilis / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism*; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D005798:Genes, Bacterial; D010457:Peptidoglycan / Q000032:analysis / Q000378:metabolism*
D010457:Peptidoglycan; D020558:GTP Phosphohydrolases