Increased CD177 (PRV1) expression in thalassaemia and the underlying erythropoietic activity.
CD177 (PRV1) expression is strongly related to polycythaemia vera (PV). Whilst studying CD177 expression in PV patients and controls, individuals with beta-thalassaemia minor were found to display an elevated expression of CD177. The study was expanded to include patients with thalassaemia intermedia, sickle cell/beta-thalassaemia and thalassaemia major. CD177 expression was increased in these thalassaemic groups and correlated with their erythropoietic activity, as assessed by the measurement of serum erythropoietin and soluble transferrin receptor levels. Within this context, elevated CD177 expression is not only a specific feature of PV but may be an indicator of increased erythropoietic activity in thalassaemia syndromes.
Zoi
Katerina
K
Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece. kzoi@bioacademy.gr
Terpos
Evangelos
E
Zoi
Christine
C
Loukopoulos
Dimitris
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood; D058851:GPI-Linked Proteins; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D007519:Isoantigens / Q000096:biosynthesis* / Q000235:genetics; D053614:Janus Kinase 2 / Q000235:genetics; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009154:Mutation; D011087:Polycythemia Vera / Q000097:blood / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D011990:Receptors, Transferrin / Q000097:blood; D017086:beta-Thalassemia / Q000097:blood* / Q000235:genetics / Q000503:physiopathology
C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D004921:Erythropoietin; C507924:JAK2 protein, human; D053614:Janus Kinase 2