title: Perinatal and neonatal outcomes of growth restricted fetuses with positive end diastolic and absent or reversed umbilical artery doppler waveforms.
abstract: OBJECTIVE
  To evaluate the outcome of intrauterine growth restriction fetuses with absent or reversed end-diastolic flow in the umbilical artery.
  
  
  METHODS
  This was a retrospective study conducted at the Department of Maternal Fetal Medicine of the Bakirkoy Women and Children's Teaching Hospital, Istanbul, Turkey between 2002 and 2006. Three hundred and ten pregnant women with growth-restricted fetuses confirmed by ultrasound were followed up with Doppler studies of the umbilical artery. The population was subdivided into 2 groups. Group 1, intrauterine growth restriction with positive end diastolic flow velocity waveforms, (n=137) and group 2, intrauterine growth restriction with absent or reversed end diastolic velocities, (n=163). Perinatal and neonatal outcomes of the 2 groups were recorded.
  
  
  RESULTS
  Group 1 was associated with a higher perinatal mortality and morbidity rate than group 2 (p=0.02), odds ratio [OR]: 1.09, 95% confidence interval [CI] 1-3.5, (p=0.03, OR: 2, 95% CI 1.2-3.2). In group 1, significantly more neonates were admitted to the neonatal intensive care unit, but no difference was seen in neonatal intensive care unit stay. The frequency of respiratory distress syndrome, septicemia, and necrotizing enterocolitis increased in group 1. There was no significant difference in need for ventilation of respiratory distress syndrome.
  
  
  CONCLUSIONS
  Our data suggest that pregnancies with absent or reversed end-diastolic flow in the umbilical arteries have high perinatal mortality and morbidity.
authors.affiliation: Department of Obstetrics and Gynecology, Maternal and Fetal Unit, Istanbul Bakirkoy Women and Children Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Yildirim
authors.forename: Erdem
authors.initials: E
authors.lastname: Turhan
authors.forename: Halil
authors.initials: H
authors.lastname: Aslan
authors.forename: Kemal
authors.initials: K
authors.lastname: Gungorduk
authors.forename: Hamit
authors.initials: H
authors.lastname: Guven
authors.forename: Ozge
authors.initials: O
authors.lastname: Idem
authors.forename: Yaduz
authors.initials: Y
authors.lastname: Ceylan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gulkilik
mesh_terms: D003971:Diastole; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D006801:Humans; D007231:Infant, Newborn; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*