Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats.
Prefrontal cortex (PFC) has been implicated in modulation of sensory information processing in somatosensory cortex. However, it remains unclear whether or not PFC regulates sensory information in thalamus. In the present study, the effect of PFC stimulation on tactile responses of neurons in the ventrobasal thalamus (VB) of the rat was investigated by single-unit recording. PFC stimulation significantly enhanced the signal-noise ratio (tactile responses/background activities) in 16 out of 66 VB neurons (24.2%) that had receptive fields in fore or hind limbs. Such changes can be classified into three different categories: (1) PFC stimulation not only increased the tactile responses, but also suppressed the background activities of neurons (six neurons, 9.1%); (2) PFC stimulation only increased the tactile responses of neurons (five neurons, 7.6%); (3) PFC stimulation only suppressed the background activities of neurons (five neurons, 7.6%). Our results suggest that PFC also modulates somatosensory information at the thalamic level.
Cao
Xiao-Hua
XH
Shanghai Institute of Brain Functional Genomics, the Key Laboratories of MOE and STCSM, East China Normal University, 3663 Zhong Shan Road, Shanghai 200062, China. xhcao@brain.ecnu.edu.cn
Wang
De-Heng
DH
Bai
Jing
J
Zhou
Shao-Ci
SC
Zhou
Yong-Di
YD
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D005121:Extremities / Q000294:innervation; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010812:Physical Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013788:Thalamus / Q000166:cytology / Q000502:physiology*; D014110:Touch / Q000502:physiology*