[Prognostic value of cyclin E and its relation to blood vessel invasion in rectal cancer].
OBJECTIVE
To investigate the expression of cyclin E in rectal carcinoma and its prognostic significance.


METHODS
Cyclin E expression was examined by Western blotting in tumor tissue samples from 130 potentially resected rectal cancer patients with pathological stages I- III. Blood vessel invasion (BVI) was detected by immunohistochemistry. Multivariate analysis using the COX proportional hazards models was applied to evaluate the independent prognostic tumor markers of rectal cancer.


RESULTS
The high expression rate of cyclin E in rectal carcinoma tissue was 23.1%(30/130). Except for a positive correlation with BVI and the gross configuration of tumor, the expression of cyclin E showed no significant relation to other clinicopathological factors. The 5-year disease-specific survival rate of cyclin E high expression group was 29.2%, which was significantly lower as compared to that of cyclin low expression group 70.5% (P<0.05). Multivariate analysis revealed that histology and cyclin E expression were independent prognostic indicators for rectal cancer patients at stages I- III. Compared to those with low expression levels, patients with high cyclin E levels had the hazard ratio (95%CI) for death from rectal cancer for 3.544 (1.528-8.215). In stage I- II, multivariate analysis showed that stronger predictive values of cyclin E expression even were detected. Patients with low cyclin E expression and negative BVI had a significantly better prognosis than those with high cyclin E expression and positive BVI.


CONCLUSIONS
The expression of cyclin E is independent prognostic factor in rectal carcinoma at stages I- III. Detecting the expression of cyclin E and/or combined with BVI may help to predict clinical outcome and design further individualized intensive adjuvant treatment.
Zhou
Yong-Jian
YJ
Department of Colorectal Surgery, Peking University School of Oncology, Beijing Institute of Cancer Research, Beijing Cancer Hospital, Beijing 100036, China. zyjbju@sina.com
Wan
Feng-Ling
FL
Yao
Li-Hua
LH
Feng
Li-Ya
LY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019927:Cyclin E / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D011379:Prognosis; D012004:Rectal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D015996:Survival Rate
D019927:Cyclin E