[Alert cell strategy for severe sepsis].
Recent progress in cellular and molecular research has provided a new insight into the improvement of multiple organ dysfunction in sepsis. This paper introduces gene therapy targeting nuclear factor- kappaB, activator protein-1 and apoptosis of inflammatory alert cells in severe sepsis.
Matsuda
Naoyuki
N
Division of Emergency Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507.
D000818:Animals; D017209:Apoptosis; D015195:Drug Design; D005786:Gene Expression Regulation; D018390:Gene Targeting; D015316:Genetic Therapy; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D009102:Multiple Organ Failure / Q000235:genetics / Q000628:therapy; D016328:NF-kappa B; D018805:Sepsis / Q000235:genetics* / Q000628:therapy*; D012720:Severity of Illness Index; D018746:Systemic Inflammatory Response Syndrome / Q000235:genetics* / Q000628:therapy*; D018808:Transcription Factor AP-1
D051741:Kruppel-Like Transcription Factors; D016328:NF-kappa B; D018808:Transcription Factor AP-1