title: Repeat mild heat shock increases dermal fibroblast activity and collagen production.
abstract: Repeat mild heat shock (RMHS) has been shown to have anti-aging effects on cellular and biological processes within human dermal fibroblasts. We have investigated the potential of an abridged mild heat shock regime to impact upon the functional properties of human dermal fibroblasts derived from three donors (male, 12 years; female, 22 years; female, 65 years). For each donor mild heat shock increased the rate of contraction of fibroblast-containing collagen gels and increased the de novo synthesis of collagen. Thus, hormetic mechanisms are proposed to provide functional anti-aging benefits to skin cells.
authors.affiliation: Unilever Corporate Research, Sharnbrook, Bedfordshire, United Kingdom. andrew.mayes@unilever.com
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Mayes
authors.forename: Caroline D
authors.initials: CD
authors.lastname: Holyoak
mesh_terms: D000328:Adult; D002460:Cell Line; D002648:Child; D003094:Collagen / Q000096:biosynthesis*; D020405:Dermis / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D005782:Gels; D018869:Heat-Shock Response; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005782:Gels; D003094:Collagen