title: Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases.
abstract: BACKGROUND
  Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm.
  
  
  METHODS
  A retrospective chart review between 1960 and 2000 was performed. Sixty-eight patients with head and neck extramedullary plasmacytomas were included.
  
  
  RESULTS
  The sinonasal tract was the most common site. Thirty-nine patients were treated with radiation, 8 with surgery, 14 with surgery and radiation, and 3 with chemoradiation. Median follow-up was 8 years. The 5-year local recurrence-free rate (LRFR) was 81%. There was a trend toward improved LRFR in patients treated primarily with radiation. Regional recurrence at 5 years was 5%. Multiple myeloma developed in 23% of patients. The 5-year survival was 76%.
  
  
  CONCLUSIONS
  Radiation is the treatment of choice with surgery reserved for large tumors and extensive bone destruction. Long-term follow-up is essential because local recurrence and disseminated disease can occur many years postdiagnosis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada.
authors.forename: Gideon
authors.initials: G
authors.lastname: Bachar
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.forename: Dale
authors.initials: D
authors.lastname: Brown
authors.forename: Richard
authors.initials: R
authors.lastname: Tsang
authors.forename: Gina
authors.initials: G
authors.lastname: Lockwood
authors.forename: Bayardo
authors.initials: B
authors.lastname: Perez-Ordonez
authors.forename: Jonathan
authors.initials: J
authors.lastname: Irish
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D004844:Epistaxis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality; D015508:Nasal Obstruction / Q000209:etiology; D009364:Neoplasm Recurrence, Local; D010954:Plasmacytoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016879:Salvage Therapy