title: Charge monitoring cell mass spectrometry.
abstract: An instrument to directly measure the charge carried by a cell or a microparticle as well as mass-to-charge ratio of the cell/microparticle was developed for rapid mass distribution measurement. A successful mass spectrum with a record high mass has been demonstrated. In this article, the details of the construction and operation of the charge monitoring cell mass spectrometer are reported. Examples are also given for demonstration and discussion.
authors.affiliation: Genomics Research Center, Institute of Physics, and Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Peng
authors.forename: Huan-Chang
authors.initials: HC
authors.lastname: Lin
authors.forename: Ming-Lee
authors.initials: ML
authors.lastname: Chu
authors.forename: Huan-Cheng
authors.initials: HC
authors.lastname: Chang
authors.forename: Hsin-Hung
authors.initials: HH
authors.lastname: Lin
authors.forename: Alice L
authors.initials: AL
authors.lastname: Yu
authors.forename: Chung-Hsuan
authors.initials: CH
authors.lastname: Chen
mesh_terms: D002138:Calibration; D002470:Cell Survival; D002478:Cells, Cultured; D006801:Humans; D007477:Ions / Q000737:chemistry; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*
chemical_list: D007477:Ions