title: Sesterterpenoids from the sponge Sarcotragus sp.
abstract: Nineteen new sesterterpenoids and eight known compounds were isolated from the sponge Sarcotragus sp. collected from Soheuksan Island, Korea. The structures of these compounds were determined to be linear sesterterpenoids containing furan or related oxygenated functionalities on the basis of combined chemical and spectroscopic analyses. In addition, the configurations of several previously undetermined compounds were assigned. Several compounds exhibited moderate to major antibacterial activity (compounds 1- 3, 17, 18) and cytotoxicity ( 3, 11, 12) against the K562 cell line and inhibitory activity against isocitrate lyase ( 6, 13).
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Jueun
authors.initials: J
authors.lastname: Song
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jang
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000201:enzymology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D020014:K562 Cells; D007723:Korea; D016106:Methicillin Resistance / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D054830:Sesterterpenes; D007522:Isocitrate Lyase