Application of proteomics in biotechnology--microbial proteomics.
The genomes of most economically important microbial cells are already sequenced and proteomic technologies can be applied during various process development steps, starting with the selection and optimization of the functions of the industrial strains, application of the knowledge of cell function in response to the changes of production parameters, validation of the downstream processing, and thorough characterization of the final product. Unfortunately, there are only a few direct examples in the literature that present the optimization of the production process based on proteomics. In this review, we discuss the potential of this technology for the design of future bioprocesses and for optimization of existing ones.
Josic
Djuro
D
Proteomics Core, COBRE Center for Cancer Research Development, Rhode Island Hospital, Providence, RI 02904, USA. Djuro_Josic@brown.edu
Kovac
Spomenka
S
D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology / Q000639:trends*; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D015202:Protein Engineering / Q000639:trends*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000639:trends*
D001426:Bacterial Proteins; D020543:Proteome