title: D-Dimer in the diagnosis of deep vein thrombosis following total hip and knee replacement: a prospective study.
abstract: BACKGROUND
  The merit of using D-dimer estimations in patients following total hip and knee replacement has been previously questioned. A survey of radiology protocols in 70 hospitals ascertained that the test continues to be mandatory in 51 prior to formal radiological investigation of suspected deep vein thrombosis (DVT) in this patient population.
  
  
  METHODS
  In this study, D-dimer levels were measured pre-operatively and during the first 7 days following primary total hip and knee replacement to estimate the range of normal values in these patients.
  
  
  RESULTS
  All 78 patients were ultrasonographically shown to be clear of DVT. D-Dimer levels were significantly raised in all patients at all measurements during the first week. Levels after total knee replacement were higher than after total hip replacement. Comparison was made with an age-matched group who had a proven DVT. There was no difference in D-dimer levels between patients with or without a DVT.
  
  
  CONCLUSIONS
  The use of this test in this patient group is a waste of resource and merely delays appropriate radiological investigation and treatment.
authors.affiliation: Manchester University, Manchester, UK.
authors.forename: A
authors.initials: A
authors.lastname: Rafee
authors.forename: D
authors.initials: D
authors.lastname: Herlikar
authors.forename: R
authors.initials: R
authors.lastname: Gilbert
authors.forename: R C
authors.initials: RC
authors.lastname: Stockwell
authors.forename: G J
authors.initials: GJ
authors.lastname: McLauchlan
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D011446:Prospective Studies; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D