Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing.
We have identified a novel HLA-B allele, B*5529. The novel allele differs from HLA-B*5501 by a single nucleotide substitution at codon 479 in exon 3 resulting in an amino acid change from alanine to valine. This alteration neither affects the peptide binding site nor the T-cell receptor (TCR) contact residues. Thus, the newly found allele is estimated to have a low alloreactive potential in case of a mismatch to the most common HLA-B allele B*5501.
Emmerich
F
F
Center for Tumor Medicine, Institute for Transfusion Medicine, Charité University Medicine, Berlin, Germany. florian.emmerich@charite.de
Schönemann
C
C
Galicki
L
L
Salama
A
A
D000483:Alleles; D019943:Amino Acid Substitution; D005260:Female; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D015235:HLA-B Antigens