Complete response of CNS-involved olfactory neuroendocrine tumor using multimodal therapy.
BACKGROUND
Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable.


METHODS
We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery.


CONCLUSIONS
To our knowledge, this combination treatment approach has not been reported in the literature.
Ahuja
Gaurav
G
Department of Medicine, The University of Illinois at Chicago, IL 60612, USA.
Cuellar
Sandra
S
Choudhry
Iffat
I
Setty
Suman
S
Yao
Mike
M
Villano
J Lee
JL
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000628:therapy*; D002166:Camptothecin / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D005004:Ethmoid Bone / Q000473:pathology*; D006801:Humans; D000077146:Irinotecan; D008297:Male; D018358:Neuroendocrine Tumors / Q000628:therapy*; D009934:Organization and Administration; D018714:Radiotherapy, Adjuvant; D012888:Skull Neoplasms / Q000628:therapy*
D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin