Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of beta-glucuronides.
The glycosynthase derived from E. coli beta-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of beta-glucuronides under mild conditions.
Wilkinson
Shane M
SM
School of Chemistry, University of Sydney, NSW 2006, Australia.
Liew
Chu W
CW
Mackay
Joel P
JP
Salleh
Hamzah M
HM
Withers
Stephen G
SG
McLeod
Malcolm D
MD
D004926:Escherichia coli / Q000201:enzymology*; D020719:Glucuronides / Q000096:biosynthesis*; D014453:Glucuronosyltransferase / Q000737:chemistry / Q000378:metabolism*; D015202:Protein Engineering
D020719:Glucuronides; D014453:Glucuronosyltransferase