Palladium-catalyzed alpha-arylation of oxindoles.
A catalyst generated from Pd(dba)2 and the bulky electron-rich phosphine ligand 2-(dicyclohexylphosphino)-2',4', 6'-tri-i-propyl-1-1'-biphenyl is effective for the alpha-arylation of oxindoles. Generation of the potassium-enolates of a range of oxindoles allows coupling with aryl chlorides, bromides, and triflates. Significant variation of the substitution pattern on both the oxindole and aryl halide is possible.
Durbin
Matthew J
MJ
Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom.
Willis
Michael C
MC
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry*
D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D010165:Palladium