Catalytic asymmetric synthesis of allylic thiol derivatives.
The palladium(II) complex [(Rp,S)-COP-Cl]2 and its enantiomer catalyze the rearrangement of linear prochiral O-allyl carbamothioates under mild conditions to provide branched S-allyl carbamothioates in high yield and high enantiomeric purity.
Overman
Larry E
LE
Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA. leoverma@uci.edu
Roberts
Scott W
SW
Sneddon
Helen F
HF
D000498:Allyl Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis*
D000498:Allyl Compounds; D013438:Sulfhydryl Compounds; D010165:Palladium