Living in context with the survival factor BAFF.
In this issue, Gardham et al. (2008) show that BAFF, a tumor necrosis factor (TNF) family member, promotes B cell survival by hindering interactions between TNF-receptor-associated factors, blocking their negative regulation of nonclassical NF-kappaB activity.
Cancro
Michael P
MP
Department of Pathology and Laboratory Medicine, 284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA. cancro@mail.med.upenn.edu
D000818:Animals; D053264:B-Cell Activating Factor / Q000276:immunology* / Q000378:metabolism; D053265:B-Cell Activation Factor Receptor / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival / Q000276:immunology*; D006801:Humans; D015398:Signal Transduction / Q000276:immunology*
D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor