title: Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder.
abstract: Transient myeloproliferative disorder (TMD) is experienced by approximately 10% of neonates with Down syndrome (DS). Most TMD is asymptomatic and the patients undergo spontaneous remission within a few months. However, some cases are fatal because of systemic organ dysfunctions including hepatic fibrosis. Some cytokines such as platelet-derived growth factor (PDGF) may be involved in the development of hepatic fibrosis in TMD. The report describes a fatal case of TMD accompanying DS. The patient presented with pulmonary hypertension and hepatic failure. An autopsy disclosed severe fibrosis in the lung, liver, kidney and pancreas. Immunohistochemical analysis revealed high expression of PDGF receptor beta in the severe fibrotic areas of the fibrotic tissues. A real-time polymerase chain reaction (PCR) analysis demonstrated the expression of PDGFalpha and PDGFbeta in the peripheral blood samples of the patient. The finding indicates that the PDGF pathway may play an important role in the fibrosis of several organs in patients with TMD.
authors.affiliation: Department of Pediatrics, University of Toyama, Toyama, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Ogawa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kanegane
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuneyama
authors.forename: Rika
authors.initials: R
authors.lastname: Kanezaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Futatani
authors.forename: Keiko
authors.initials: K
authors.lastname: Nomura
authors.forename: Shin
authors.initials: S
authors.lastname: Ishizawa
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Sasahara
authors.forename: Etsuro
authors.initials: E
authors.lastname: Ito
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyawaki
mesh_terms: D004314:Down Syndrome / Q000150:complications*; D005355:Fibrosis / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009196:Myeloproliferative Disorders / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta; D017479:Receptors, Platelet-Derived Growth Factor / Q000032:analysis*
chemical_list: D010982:Platelet-Derived Growth Factor; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta; D017479:Receptors, Platelet-Derived Growth Factor