Pentoxifylline to treat radiation proctitis: a small and inconclusive randomised trial.
This prospective randomised controlled study of 40 patients could not show a statistically significant advantage with 6 months of pentoxifylline compared with standard measures for late radiation-induced rectal bleeding. However, a modest benefit cannot be excluded and larger randomised placebo-controlled trials with longer durations of pentoxifylline treatment may be justified.
Venkitaraman
R
R
Academic Urology Unit, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, UK.
Price
A
A
Coffey
J
J
Norman
A R
AR
James
F V
FV
Huddart
R A
RA
Horwich
A
A
Dearnaley
D P
DP
D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy; D006801:Humans; D010431:Pentoxifylline / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011349:Proctitis / Q000188:drug therapy* / Q000209:etiology; D011832:Radiation Injuries / Q000628:therapy*
D010975:Platelet Aggregation Inhibitors; D010431:Pentoxifylline