title: Physical activity prevents bone loss in premenopausal women with rheumatoid arthritis: a cohort study.
abstract: The aim of the study was to compare the bone loss and the influence of physical activity between premenopausal women with rheumatoid arthritis (RA) and healthy women. A total of 71 patients with RA and 29 healthy premenopausal women with the criteria of the American College of Rheumatology for RA were followed for 2 years. Of these 85% were Caucasian, aged 38 +/- 6.6 years and with a duration of disease of 88 +/- 50 months and 48 (71.8%) used GC, mean daily dose, 7.3 +/- 3.5 mg. There was a reduction in the T-score of the femoral neck (P = 0.04) and in the Ward region (P = 0.05) in RA. Through logistic regression, it was found that sedentarism was a risk factor for osteopenia in RA, with relative risk of 1.6 (IC = 1.238-1.734). Moderate physical activity reduced the risk of osteopenia by 50%. Sedentarism and low weight are the main factors associated with bone loss. Physical activity reduces bone loss. Early preventive and therapeutic measures must be encouraged.
authors.affiliation: Departamento de Medicina Interna, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. tatianft@yahoo.com.br
authors.forename: Tatiana Freitas
authors.initials: TF
authors.lastname: Tourinho
authors.forename: Edison
authors.initials: E
authors.lastname: Capp
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Brenol
authors.forename: Airton
authors.initials: A
authors.lastname: Stein
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000517:prevention & control; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008159:Lumbar Vertebrae; D009043:Motor Activity; D010024:Osteoporosis / Q000453:epidemiology* / Q000517:prevention & control*; D017697:Premenopause; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids