title: Efficacy of benzoxazinorifamycins in a mouse model of Chlamydia pneumoniae lung infection.
abstract: The efficacy of rifalazil and other benzoxazinorifamycins was tested in a mouse model of lung infection against Chlamydia pneumoniae. Rifalazil and six related new chemical entities all showed efficacy after one dose per day for 3 days at either 3 or 1 mg/kg of body weight.
authors.affiliation: Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Campbell
authors.forename: Cho-Chou
authors.initials: CC
authors.lastname: Kuo
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Suchland
authors.forename: David M
authors.initials: DM
authors.lastname: Rothstein
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002690:Chlamydia Infections / Q000188:drug therapy*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004195:Disease Models, Animal; D008168:Lung / Q000187:drug effects* / Q000382:microbiology; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D012294:Rifamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012294:Rifamycins; C068980:KRM 1648