Successful treatment of postoperative fungal endophthalmitis using intravitreal and intracameral voriconazole.
OBJECTIVE
The aim of this study was to describe 3 cases of postoperative fungal endophthalmitis successfully treated with anterior chamber washout, pars plana vitrectomy, and intracameral and intravitreal voriconazole injection.


RESULTS
Three (3) patients from a single retina center in India developed culture-proven fungal endophthalmitis after cataract surgery in 1 eye. All patients underwent anterior chamber washout, pars plana vitrectomy, and intracameral and intravitreal voriconazole injections intraoperatively. All cases demonstrated substantial improvement in vision and intraocular inflammation after surgery.


CONCLUSIONS
The combination of anterior chamber washout, pars plana vitrectomy, and intracameral and intravitreal voriconazole injection is a viable therapeutic option in cases of fungal endophthalmitis.
Lin
Richard C
RC
Department of Ophthalmology, University of Chicago, Chicago, IL 60637, USA.
Sanduja
Neeraj
N
Hariprasad
Seenu M
SM
D000368:Aged; D000867:Anterior Chamber / Q000378:metabolism; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002387:Cataract Extraction / Q000009:adverse effects*; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology; D015821:Eye Infections, Fungal / Q000188:drug therapy; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole