title: Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
abstract: We investigated the antistaphylococcal activities of daptomycin, gentamicin, and rifampin against two Staphylococcus aureus strains and their stable small-colony variants, singly and in combination, in human monocyte-derived macrophages and in broth. Intracellularly, the three-drug combination and two-drug combinations with rifampin were most effective. Extracellularly, daptomycin, daptomycin plus gentamicin, gentamicin plus rifampin, and the three-drug combination had similar activities.
authors.affiliation: Infectious Disease Research Laboratory, Stratton VA Medical Center, Albany, NY 12208, USA. Aldona.Baltch@med.va.gov
authors.forename: Aldona L
authors.initials: AL
authors.lastname: Baltch
authors.forename: William J
authors.initials: WJ
authors.lastname: Ritz
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Bopp
authors.forename: Phyllis
authors.initials: P
authors.lastname: Michelsen
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Smith
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D017576:Daptomycin / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000821:virology; D008826:Microbial Sensitivity Tests; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000821:virology; D012293:Rifampin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D017576:Daptomycin; D012293:Rifampin