title: Pregnancy outcome in fetuses with increased nuchal translucency.
abstract: OBJECTIVE
  The aim of this study was to examine fetal and neonatal outcomes in the setting of nuchal translucency (NT) > or =3 mm at routine first-trimester screening.
  
  
  METHODS
  A nested case-series study within a retrospective cohort of women screened for Down syndrome at 11-14 weeks of gestation. Crown-rump length, NT values and additional anomalies at first and early second trimesters were recorded. Follow-up information was obtained by a review of medical records and self-report from patients. Adverse outcomes included fetal death and termination of pregnancy due to structural or chromosomal anomalies.
  
  
  RESULTS
  A total of 1930 pregnant women were screened between 11 and 14 weeks of gestation. The prevalence of increased fetal NT (> or =3 mm) was 1.4% (n=27). Among these, 12 showed increased fetal NT as an isolated finding. In this group, 2 women experienced fetal demise (16%) and 10 delivered healthy babies. In the group with additional abnormalities (n=15), 9 (60%) were found to have chromosomal abnormalities, all of which were terminated. For all cases with increased fetal NT, total incidence of adverse outcome was 62%.
  
  
  CONCLUSIONS
  At first-trimester ultrasonography, a fetal NT > or =3 mm was associated with a high incidence of chromosomal abnormalities in the presence of associated abnormalities. For cases with the increased fetal NT at first-trimester fetal assessment and follow-up is necessary to detect possible adverse outcomes.
authors.affiliation: Division of Perinatology, Department of Gynecology and Obstetrics, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Dane
authors.forename: C
authors.initials: C
authors.lastname: Dane
authors.forename: A
authors.initials: A
authors.lastname: Cetin
authors.forename: M
authors.initials: M
authors.lastname: Kiray
authors.forename: D
authors.initials: D
authors.lastname: Sivri
authors.forename: M
authors.initials: M
authors.lastname: Yayla
mesh_terms: D016022:Case-Control Studies; D004314:Down Syndrome / Q000000981:diagnostic imaging; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First