Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp. ZSU-H76.
Three metabolites named phomopsin A (1), B (2) and C (3), together with two known compounds cytosporone B (4) and C (5), were isolated from the mangrove endophytic fungus, Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly by 1D and 2D NMR spectroscopic techniques. The medium-sized cyclic phenol ether based on 1 or 2 is rare in natural products. In bioassays, compounds 1, 2, and 3 had no significant antibiotic activities, but compounds 4 and 5 inhibited two fungi Candida albicans and Fusarium oxysporum with an MIC ranging from 32 to 64 microg/ml.
Huang
Zhongjing
Z
School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, PR China.
Cai
Xiaoling
X
Shao
Changlun
C
She
Zhigang
Z
Xia
Xuekui
X
Chen
Yiguang
Y
Yang
Jianxiang
J
Zhou
Shining
S
Lin
Yongcheng
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D032407:Avicennia / Q000382:microbiology*; D002176:Candida albicans / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry* / Q000494:pharmacology*; D009842:Oligopeptides
D000900:Anti-Bacterial Agents; D009183:Mycotoxins; C035753:phomopsin; D009842:Oligopeptides