title: An ultrasensitive assay for diagnosis of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia. Aging is among the most significant risk factors. Today, AD can be diagnosed with certainty only post mortem, detecting insoluble beta-amyloid peptide (Abeta) aggregates in the patient's brain tissue. We have developed an ultrasensitive assay for early and non-invasive diagnosis of AD. This highly specific and sensitive assay uses fluorescence correlation spectroscopy (FCS) and is sensitive enough to detect even single aggregates in body fluids of AD patients. We investigate the correlation of aggregated Abeta concentrations in body fluids with clinical symptoms of AD.
authors.affiliation: Forschungszentrum Jülich, INB-2, Jülich, Germany.
authors.forename: Susanne Aileen
authors.initials: SA
authors.lastname: Funke
authors.forename: Eva
authors.initials: E
authors.lastname: Birkmann
authors.forename: Franziska
authors.initials: F
authors.lastname: Henke
authors.forename: Philipp
authors.initials: P
authors.lastname: Görtz
authors.forename: Christian
authors.initials: C
authors.lastname: Lange-Asschenfeldt
authors.forename: Detlev
authors.initials: D
authors.lastname: Riesner
authors.forename: Dieter
authors.initials: D
authors.lastname: Willbold
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D020836:Protein Structure, Quaternary; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D016229:Amyloid beta-Peptides