title: Eosinophilic bronchitis-like lesion as the cause of death in a Macaca mulatta: a first case report.
abstract: BACKGROUND
  Eosinophilic bronchitis is a recently described, relatively benign condition in humans that is characterized by a corticosteroid-responsive chronic cough and sputum eosinophilia without the abnormalities of airway function seen in asthma. The exact cause of this condition is currently unknown, however has been associated with various occupational exposures in humans. It has also been reported to progress to irreversible airway obstruction. This disease has been reported in dogs and horses, but not in non-human primates.
  
  
  METHODS
  Gross examination of an otherwise healthy 13-year-old, colony-born Macaca mulatta, which died of severe non-responsive respiratory distress revealed that the lungs were markedly inflated and moist.
  
  
  RESULTS
  Hematoxylin and eosin-stained sections from the lungs contained widespread accumulation of eosinophils, sloughed epithelial cells, and mucus centered around bronchioles and adjacent airways. There was no evidence of mast cell infiltration of peribronchiolar smooth muscle, goblet cell hyperplasia, or basement membrane thickening.
  
  
  CONCLUSIONS
  This ruled out recurrent episodes as would be expected in asthma, favoring the diagnosis of an eosinophilic bronchitis-like lesion. We report a first case of eosinophilic bronchitis-like features in a M. mulatta.
authors.affiliation: Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Christal
authors.forename: G B
authors.initials: GB
authors.lastname: Hubbard
authors.forename: E J
authors.initials: EJ
authors.lastname: Dick
authors.forename: K M
authors.initials: KM
authors.lastname: Brasky
authors.forename: J
authors.initials: J
authors.lastname: Jagirdar
mesh_terms: D000818:Animals; D001991:Bronchitis / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D008168:Lung / Q000473:pathology; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*; D011657:Pulmonary Eosinophilia / Q000473:pathology / Q000662:veterinary*