title: Synthesis of bis-diosgenin pyrazine dimers: new cephalostatin analogs.
abstract: A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of alpha-amino ketones, the most efficient method for pyrazine ring construction.
authors.affiliation: Department of Applied Chemical Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. shawakfa@just.edu
authors.forename: Khaled Q
authors.initials: KQ
authors.lastname: Shawakfeh
authors.forename: Naim H
authors.initials: NH
authors.lastname: Al-Said
authors.forename: Raed M
authors.initials: RM
authors.lastname: Al-Zoubi
mesh_terms: D019281:Dimerization; D004144:Diosgenin / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D011719:Pyrazines; D004144:Diosgenin