In-vitro evaluation of selected chalcones for antioxidant activity.
Synthetic chalcones (SCs) having different side chains on the 1-(2-Hydroxy-3-(2-hydroxy-cyclohexyl)-4,6 dimethoxy-phenyl(-methanone structure were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity, reducing ability, OH radical scavenging activity, inhibition of polyphenol oxidase (PPO) and formation of diene conjugates. Overall, with few exceptions, all the SCs showed moderate biological activity in all the parameters examined. The SCs were found to be reactive towards DPPH radical and had considerable reducing ability. With few exceptions, all the test compounds under study were found to possess moderate to poor OH radical scavenging activity and inhibited PPO significantly and all were found to be effective inhibitors of hydroperoxide formation. These findings suggest that these SCs can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates.
Gacche
R N
RN
School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, MS, India. rngacche@rediffmail.com
Dhole
N A
NA
Kamble
S G
SG
Bandgar
B P
BP
D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D010851:Picrates
D000975:Antioxidants; D001713:Biphenyl Compounds; D047188:Chalcones; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D004156:Catechol Oxidase