Severe drug hypersensitivity reaction in a young woman treated with doxycycline.
Doxycycline is a commonly prescribed medication for the management of acne vulgaris. Severe adverse reactions to this medication are uncommon. We describe an unusual case of a 20-year-old female who experienced a life-threatening hypersensitivity reaction, including fever, lymphadenopathy, hepatitis, nephritis and severe pneumonitis with respiratory failure following oral administration of doxycycline for facial acne.
Robles
David T
DT
Department of Medicine, Division of Dermatology, University of Washington Medical Center, Seattle, Washington 98105-6524 , USA. drobles@u.washington.edu
Leonard
Jennifer L
JL
Compton
Nicholas
N
Waghmare
Alpana
A
McDonough
Karen A
KA
George
Evan
E
Wolgamot
Greg
G
Fleckman
Philip
P
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004318:Doxycycline / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D004487:Edema / Q000473:pathology; D004802:Eosinophilia / Q000139:chemically induced; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced; D009393:Nephritis / Q000139:chemically induced*; D011014:Pneumonia / Q000139:chemically induced*; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012867:Skin / Q000473:pathology; D013577:Syndrome
D000900:Anti-Bacterial Agents; D004318:Doxycycline