title: Histologic findings in T-cell lymphoma infiltration of the optic nerve.
abstract: OBJECTIVE
  To report the clinical and histologic features of lymphomatous infiltration of the optic nerve by systemic T-cell non-Hodgkin's lymphoma (NHL).
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A patient with peripheral T-cell NHL.
  
  
  METHODS
  A 39-year-old man with a diagnosis of peripheral T-cell NHL, stage IV, with CNS involvement and decreased vision was found to have lymphomatous infiltration of the optic nerves.
  
  
  METHODS
  Visual acuity.
  
  
  RESULTS
  Despite treatment with chemotherapy and an optic nerve sheath fenestration, the patient lost vision in the right eye and subsequently underwent an optic nerve biopsy. The histopathology showed diffuse infiltration with a clonal population of lymphocytic cells that were CD3 positive and CD20 negative, consistent with T-cell NHL.
  
  
  CONCLUSIONS
  Optic nerve infiltration from systemic B-cell lymphoma is rare and has been reported; we report an unusual case of bilateral optic nerve infiltration secondary to peripheral T-cell NHL.
authors.affiliation: Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester,Minnesota 55905, USA.
authors.forename: Anna S
authors.initials: AS
authors.lastname: Kitzmann
authors.forename: Jose S
authors.initials: JS
authors.lastname: Pulido
authors.forename: James A
authors.initials: JA
authors.lastname: Garrity
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Witzig
mesh_terms: D000328:Adult; D018951:Antigens, CD20 / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017252:CD3 Complex / Q000378:metabolism; D016543:Central Nervous System Neoplasms / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D009900:Optic Nerve / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D014792:Visual Acuity
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex