title: Prospective randomized comparison of oxybutynin, functional electrostimulation, and pelvic floor training for treatment of detrusor overactivity in women.
abstract: The purpose of this study is to compare the effectiveness of oxybutynin, functional electrostimulation (FES), and pelvic floor training (PFT) for treatment of women with detrusor overactivity. Sixty-four subjects were randomized to oxybutynin (n=22), FES (n=21), or PFT (n=21). Women were evaluated before and after completion of 12 weeks of treatment by subjective response, voiding diary, and urodynamic test. There was subjective symptomatic improvement in 77% of the women treated with oxybutynin, 52% with FES, and 76% with PFT. Urgency resolved in 64% of women treated with oxybutynin, 52% with FES, and in 57% with PFT. Urodynamic evaluation was normal in 36% treated with oxybutynin, 57% with FES, and 52% with PFT. Maximum detrusor involuntary contraction pressure decreased in all groups (p<0.05). All treatments were equally effective. Subjective reduction of urge-incontinence episodes was associated with symptomatic improvement.
authors.affiliation: Department of Urogynecology, Federal University of São Paulo, R. Loefgreen, 1654/14, Vila. Clementino, 04040-002 São Paulo, Brazil. raquel.arruda@yahoo.com.br
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Arruda
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Castro
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Sousa
authors.forename: Marair G F
authors.initials: MG
authors.lastname: Sartori
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Baracat
authors.forename: Manoel J B C
authors.initials: MJ
authors.lastname: Girão
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008333:Mandelic Acids / Q000627:therapeutic use*; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D017773:Pelvic Floor; D026741:Physical Therapy Modalities; D011446:Prospective Studies; D053201:Urinary Bladder, Overactive / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics
chemical_list: D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C005419:oxybutynin