title: Cervical cancer screening program integrating Pap smear and HPV DNA testing: a population-based study.
abstract: We conducted a population-based cohort study to evaluate the complementary value of HPV testing to Papanicolaou (Pap) smear and the prevalence and genotype distribution of HPV in Taiwan. In this report, we described the design of the whole study and analyzed the cross-sectional results. Female residents (age >or= 30 years) of Taoyuan, Taiwan were invited. After signing informed consent, every participant had a Pap smear and a HPV testing. Patients with Pap >or= atypical squamous cell of undetermined significance (Group I) or those with HPV-positive but normal cytology (Group II) were referred for a colposcopic examination. A total of 10,014 women were eligible. The overall HPV prevalence was 10.8% (95% confidence interval 10.5%-11.4%) in the study population. A total of 37 types of HPV were identified and the leading three were HPV-52, -18 and -58. There was a significant positive correlation of HPV prevalence with older age, postmenopausal status, current-user of oral contraceptives and never-user of hormone replacement therapy. Past users of oral contraceptives and never users of Pap were associated with higher risk of abnormal Pap, while age 40-49 strata had lower risk. Fifty-nine cases of cervical intraepithelial neoplasia (CIN) 2 from Group I and additional 11 from Group II were identified. The improvement of sensitivity with additional HPV testing was 15.3%. Besides, no specific subgroup was found to most benefit from the combined strategy. The value of adding HPV test to conventional Pap smear has to be evaluated after longer-term follow-up of this population-based cohort.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors.forename: Angel
authors.initials: A
authors.lastname: Chao
authors.forename: Kuang-Hung
authors.initials: KH
authors.lastname: Hsu
authors.forename: Chyong-Huey
authors.initials: CH
authors.lastname: Lai
authors.forename: Huei-Jean
authors.initials: HJ
authors.lastname: Huang
authors.forename: Swei
authors.initials: S
authors.lastname: Hsueh
authors.forename: Sheue-Rong
authors.initials: SR
authors.lastname: Lin
authors.forename: Shih-Ming
authors.initials: SM
authors.lastname: Jung
authors.forename: Fang-Yu
authors.initials: FY
authors.lastname: Chao
authors.forename: Shang-Lang
authors.initials: SL
authors.lastname: Huang
authors.forename: Chu-Chun
authors.initials: CC
authors.lastname: Huang
authors.forename: Jung-Erh
authors.initials: JE
authors.lastname: Yang
authors.forename: Ting-Chang
authors.initials: TC
authors.lastname: Chang
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral