Central retinal vein occlusion associated with clomiphene-induced ovulation.
OBJECTIVE
To report a case of central retinal vein occlusion associated with clomiphene citrate (CC).


METHODS
Case study.


METHODS
Ophthalmology clinic of an academic hospital.


METHODS
A 36-year-old woman referred from the infertility clinic for blurred vision.


METHODS
Ophthalmic examination after CC therapy.


METHODS
Central retinal vein occlusion after ovulation induction with CC.


RESULTS
A 36-year-old Chinese woman developed central retinal vein occlusion after eight courses of CC. A search of the literature on the thromboembolic complications of CC does not include this severe ophthalmic complication, although mild visual disturbance after CC intake is not uncommon.


CONCLUSIONS
This is the first reported case of central retinal vein occlusion after treatment with CC. Extra caution is warranted in treating infertility patients with CC, and patients should be well informed of this side effect before commencement of therapy.
Lee
Vincent Y W
VY
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. vincent.leeyw@gmail.com
Liu
David T L
DT
Li
Chi-Lai
CL
Hoi-Fan
Lam
Dennis S C
DS
D000328:Adult; D002996:Clomiphene / Q000009:adverse effects*; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D010062:Ovulation Induction / Q000009:adverse effects*; D011859:Radiography; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D016896:Treatment Outcome; D014221:Triamcinolone / Q000627:therapeutic use; D014786:Vision Disorders / Q000139:chemically induced; D014792:Visual Acuity / Q000187:drug effects
D005300:Fertility Agents, Female; D005938:Glucocorticoids; D002996:Clomiphene; D014221:Triamcinolone