title: Recent advances and perceptions in studies of heterodimerization between G protein-coupled receptors.
abstract: G protein coupled-receptors (GPCR) have been shown to form heterodimers or heterooligomers with various biochemical and/or pharmacological activity that are distinct from those of the corresponding monomers or homomers. Recent in vitro and in vivo experimental data have also shown novel functional roles of several orphan GPCRs as modulatory units of heterodimers and potentials for development of heterodimer-selective clinical agents. In this review, we summarize essential and latest knowledge as to GPCR heterodimerizations and the current issues to be solved in the near future.
authors.affiliation: Suntory Institute for Bioorganic Research, Wakayamadai 1-1-1, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan. satake@sunbor.or.jp
authors.forename: Honoo
authors.initials: H
authors.lastname: Satake
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Sakai
mesh_terms: D000818:Animals; D001665:Binding Sites; D019281:Dimerization; D006801:Humans; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled