title: [Homocysteine levels in patients with obstructive sleep apnea syndrome].
abstract: The exact mechanism of development of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS) remains to be unknown. The role of homocysteine in atherosclerotic disease process has become well established over the past ten years. Our aim was to study to compare homoscysteine levels between OSAS and control levels. Sixty-two subjects with OSAS and twelve similar controls in age, gender, body mass index, smoking and coronary heart disease were included in this prospective study. Serum levels of homocysteine (13.5 +/- 6.0 micromol/L vs. 10.2 +/- 2.9 micromol/L, p= 0.03) in the OSAS group were significantly greater than those in the control group. Logistic regression analyses showed that OSAS (Odds ratio: 9.08 95% CI 2.347-35.120; p= 0.001) was independent risk factors for high levels of serum homocysteine in age, smoking status, diabetes mellitus and coronary heart disease. We conclude that homocysteine may be an important factor for development of cardiovascular disease in patients with OSAS.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Uludağ University, Bursa, Turkey.
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Yavuz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ursavaş
authors.forename: Ercüment
authors.initials: E
authors.lastname: Ege
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Ozarda Ilçol
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karadağ
authors.forename: Esra
authors.initials: E
authors.lastname: Uzaslan
authors.forename: R Oktay
authors.initials: RO
authors.lastname: Gözü
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications* / Q000175:diagnosis
chemical_list: D006710:Homocysteine