title: High rate of complicated idiopathic gallstone disease in pediatric patients of a North American tertiary care center.
abstract: OBJECTIVE
  To assess spectrum and etiology of gallstones and biliary sludge in the pediatric population of a North American tertiary care centre.
  
  
  METHODS
  Retrospective review of abdominal ultrasounds recorded at Saint Justine Hospital over a period of 24 mo (8/2003 to 8/2005) in patients < 19 years of age. Patients < 2 years of age were analyzed separately.
  
  
  RESULTS
  The presence of gallstones was noted in 127 patients. In 107 it was a new diagnosis, in 48/105 (45.7%) patients > 2 years of age idiopathic gallstone disease was found. These 48 patients represent 2.1% of the population who required ultrasound for abdominal pain. Complicated gallstone disease occurred in 28/48 with idiopathic disease, mainly adolescent girls. Patients with hemolytic disorders, cystic fibrosis, oncologic diseases or kidney transplantation and gallstones were asymptomatic and stones were detected during routine abdominal ultrasound. Twenty two patients < 2 years of age not consulting for abdominal pain had gallstone disease of diverse etiology. Biliary sludge was seen in 84 patients, 78.5% on total parenteral nutrition. In 4 patients, sludge progressed to gallstones.
  
  
  CONCLUSIONS
  Idiopathic gallstone disease and its rate of complication are more frequent in our cohort than expected from previous studies. Adolescent girls with abdominal pain and idiopathic gallstones require special attention for complicated disease course.
authors.affiliation: Division of Gastroenterology and Nutrition, Saint Justine Hospital, 3175, Cote Sainte-Catherine, Montreal, Quebec, Canada. denise.herzog@umontreal.ca
authors.forename: Denise
authors.initials: D
authors.lastname: Herzog
authors.forename: Guylaine
authors.initials: G
authors.lastname: Bouchard
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001646:Bile / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D002763:Cholecystectomy; D018450:Disease Progression; D042882:Gallstones / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000601:surgery; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D009656:North America / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D014463:Ultrasonography