title: Performance of limited sampling strategies for predicting mycophenolic acid area under the curve in thoracic transplant recipients.
abstract: METHODS
  Eight limited sampling strategies (LSSs) for estimating mycophenolic acid area under the concentration-time curve (4 developed from lung transplant recipients at our center, 4 developed for heart transplant recipients from other research groups) were evaluated in 27 heart or heart-kidney transplant patients.
  
  
  RESULTS
  The LSSs from our lung transplant patients performed well when applied to the heart transplant population, with percent bias and percent precision within the acceptable limit of +/-15%.
  
  
  CONCLUSIONS
  The LSSs developed at our center are robust enough to be applied to both lung and heart transplant populations. Application of LSSs from other research groups yielded less optimal results, reinforcing the need to re-establish or re-validate LSSs for each specific center.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Lillian S L
authors.initials: LS
authors.lastname: Ting
authors.forename: Nilufar
authors.initials: N
authors.lastname: Partovi
authors.forename: Robert D
authors.initials: RD
authors.lastname: Levy
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Ignaszewski
authors.forename: Mary H H
authors.initials: MH
authors.lastname: Ensom
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001682:Biological Availability; D005260:Female; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D016040:Lung Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011237:Predictive Value of Tests; D012494:Sampling Studies
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid