The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.
Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stress-inducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.
Gehrmann
Mathias
M
Department of Radiotherapy and Radiooncology and Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)-Institute of Pathology, University Hospital rechts der Isar, Technische Universität München, Ismaningerstrasse 22, Munich, Germany.
Radons
Jürgen
J
Molls
Michael
M
Multhoff
Gabriele
G
D000595:Amino Acid Sequence; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000528:radiation effects; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D016513:Mice, SCID; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy / Q000628:therapy*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use; D013312:Stress, Physiological / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D014212:Tretinoin