Malaria combination therapies: advantages and shortcomings.
Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.
Martinelli
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A
Centro de Malária e Outras Doenças, Tropicais/IHMT/UEI Biologia Molecular, Rua da Junqueira 96. 1349-008 Lisbon, Portugal. amartinelli@ihmt.unl.pt
Moreira
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R
Ravo
P V L
PV
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D004351:Drug Resistance / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000188:drug therapy*
D000962:Antimalarials