title: Central neurocytoma responsive to topotecan, ifosfamide, carboplatin.
abstract: A 5-year-old male presented with spinal cord drop metastasis from a recurrent neurocytoma. Topotecan (0.5 mg/m(2)) and carboplatin (250 mg/m(2)) were administered on days 1-3 and ifosfamide (1,800 mg/m(2)) on days 1-5, every 21 days, for three cycles and resulted in complete response without severe complications. A literature review yielded 20 patients with central neurocytoma but no complete responses. The complete response of central neurocytoma to chemotherapy only reported here should be helpful to those caring for patients with this rare tumor.
authors.affiliation: Department of Pediatrics, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
authors.forename: Elham
authors.initials: E
authors.lastname: Amini
authors.forename: Tina
authors.initials: T
authors.lastname: Roffidal
authors.forename: Alice
authors.initials: A
authors.lastname: Lee
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Fuller
authors.forename: Anita
authors.initials: A
authors.lastname: Mahajan
authors.forename: Leena
authors.initials: L
authors.lastname: Ketonen
authors.forename: Nathan
authors.initials: N
authors.lastname: Kobrinsky
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Cairo
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Wells
authors.forename: Johannes E A
authors.initials: JE
authors.lastname: Wolff
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin; D002675:Child, Preschool; D018572:Disease-Free Survival; D006801:Humans; D007069:Ifosfamide; D008279:Magnetic Resonance Imaging; D008297:Male; D018306:Neurocytoma / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction; D019772:Topotecan
chemical_list: D019772:Topotecan; D016190:Carboplatin; D007069:Ifosfamide