title: Intensifying the saturation biopsy technique for detecting prostate cancer after previous negative biopsies: a step in the wrong direction.
abstract: OBJECTIVE
  To report the results using an extensive saturation biopsy in men with negative prostate biopsies but in whom there is still a clinical suspicion for carcinoma.
  
  
  METHODS
  Between February 1999 and October 2004 we offered 40 patients (median age 63 years) an extensive saturation biopsy if there was clinical suspicion of prostate cancer after previous negative prostate biopsies. The median (range) number of cores taken was 64 (39-139) and was adjusted to the size of the prostate. All patients received general or spinal anaesthesia.
  
  
  RESULTS
  Of the 40 patients, 18 (45%) had carcinoma in at least one core; 16 had a radical prostatectomy, which showed pT2a, pT2b, pT2c, pT3a and pT3b adenocarcinoma of the prostate in three, four, six, two and one patients, respectively. Brachytherapy and external radiation were the therapies of choice in the other patients. Sixteen patients had marked haematuria after the biopsy procedure.
  
  
  CONCLUSIONS
  There is no significant increase in the cancer detection rate in an extensive saturation-biopsy regimen compared to published series with fewer cores, but the morbidity increased.
authors.affiliation: Department of Urology, University of Ulm, Ulm, and Krankenhaus Göttingen-Weende, Göttingen, Germany. joerg.simon@uniklinik-ulm.de
authors.forename: Jörg
authors.initials: J
authors.lastname: Simon
authors.forename: Rainer
authors.initials: R
authors.lastname: Kuefer
authors.forename: Georg
authors.initials: G
authors.lastname: Bartsch
authors.forename: Björn G
authors.initials: BG
authors.lastname: Volkmer
authors.forename: Richard E
authors.initials: RE
authors.lastname: Hautmann
authors.forename: Hans-Werner
authors.initials: HW
authors.lastname: Gottfried
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D017430:Prostate-Specific Antigen