Agammaglobulinemia and Staphylococcus aureus botryomycosis in a cohort of related sentinel Swiss Webster mice.
Sentinel mouse seroconversion to infectious agents is critical for laboratory animal facility disease monitoring. We report spontaneous emergence of non-sex-linked agammaglobulinemia with B-cell deficiency and cutaneous Staphylococcus aureus granulomatosis (botryomycosis) in a cohort of related Swiss Webster sentinel mice. Our experience reinforces the importance of immunocompetency validation in surveillance programs.
Bridgeford
Erin C
EC
Division of Comparative Medicine 16-825, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ecbridge@mit.edu
Fox
James G
JG
Nambiar
Prashant R
PR
Rogers
Arlin B
AB
D000361:Agammaglobulinemia / Q000150:complications*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D051379:Mice; D018571:Sentinel Surveillance; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013207:Staphylococcal Skin Infections / Q000276:immunology* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification*