Total synthesis of (+/-)-dysibetaine.
The marine natural product dysibetaine was synthesized in racemic form from a levulinic acid derivative using a convertible isocyanide and an ammonium acetate in the Ugi 4-center-3-component condensation reaction.
Isaacson
Jerry
J
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive Mail Code 0343, La Jolla, California 92093-0343, USA.
Loo
Mandy
M
Kobayashi
Yoshihisa
Y
D000818:Animals; D002384:Catalysis; D018360:Crystallography, X-Ray; D047088:Dysidea / Q000737:chemistry; D007982:Levulinic Acids / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007982:Levulinic Acids; D011760:Pyrrolidinones; C431075:dysibetaine; C032246:levulinic acid