title: The role of blood transfusion in the management of upper and lower intestinal tract bleeding.
abstract: Patients with gastrointestinal (GI) haemorrhage use 13.8% of all red blood cell transfusions in England. This review addresses the evidence for red blood cell, fresh frozen plasma and platelet transfusions in acute and chronic blood loss, from both the upper and lower intestinal tract. It reviews the indications for transfusion in GI bleeding, the haematological consequences of massive blood loss and massive transfusion, and the importance of managing coagulopathy in bleeding patients. It also looks at the safety and risks of blood transfusion, and provides clinicians with evidence to reduce unnecessary transfusion. Large controlled clinical trials of blood transfusion specifically in GI bleeding are required, along with further research into the use of adjuvant therapies such as recombinant activated factor VIIa. Changing clinician behaviour to reduce inappropriate blood transfusion remains a key target for future transfusion research.
authors.affiliation: National Blood Service, John Radcliffe Hospital, Oxford OX3 9BQ, UK. sarah.hearnshaw@nbs.nhs.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Hearnshaw
authors.forename: Simon
authors.initials: S
authors.lastname: Travis
authors.forename: Mike
authors.initials: M
authors.lastname: Murphy
mesh_terms: D000208:Acute Disease; D001803:Blood Transfusion; D002908:Chronic Disease; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D006801:Humans; D012151:Resuscitation / Q000379:methods; D012449:Safety; D065227:Transfusion Reaction