title: Comparative antiviral (HIV) photoactivity of metalized meso- tetraphenylsulfonated porphyrins.
abstract: We have carried out the study of the photochemical properties of a series of synthetic meso-tetraphenylsulfonated porphyrins (TPPMS4) bonded to several metal ions such as: Cu(II), Zn(II), Pd(II), Mn(II), Fe(III), Ni(II) and Co(II) for the optimization of their clinical applications as antiviral agents against the human immunodeficiency virus (HIV-1) as well as the study of the in vitro antiviral photoinactivation mechanisms with future application in blood sterilization. A selective inhibition has been determined in the viral growth (HIV-1) when this is irradiated in the presence of the complex TPPFeS4 and TPPMnS4 (photosensitizer-mediated Type I reaction) as well as in the 1O2-mediated (Type II reaction) in the presence of TPPPdS4 and TPPZnS4, remaining cellular viability unaltered in each case.
authors.affiliation: Laboratorio de Fotoquímica, Centro de Química, Instituto Venezolano de Investigaciones Cientificas I.V.I.C., Caracas 1020-A, Venezuela. fvargas@ivic.ve
authors.forename: Franklin
authors.initials: F
authors.lastname: Vargas
authors.forename: Carlos
authors.initials: C
authors.lastname: Rivas
authors.forename: Tamara
authors.initials: T
authors.lastname: Zoltan
authors.forename: Liliana
authors.initials: L
authors.lastname: Padrón
authors.forename: Carla
authors.initials: C
authors.lastname: Izzo
authors.forename: Verónica
authors.initials: V
authors.lastname: López
authors.forename: Lubimar
authors.initials: L
authors.lastname: Gómez
authors.forename: Flor
authors.initials: F
authors.lastname: Pujol
authors.forename: Hector
authors.initials: H
authors.lastname: Rangel
authors.forename: Domingo
authors.initials: D
authors.lastname: Garzaro
authors.forename: Rona
authors.initials: R
authors.lastname: Fabbro
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival; D015497:HIV-1 / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D019216:Metals, Heavy; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D013242:Sterilization / Q000379:methods*
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D008665:Metalloporphyrins; D019216:Metals, Heavy; D017319:Photosensitizing Agents