title: A giant cystic pheochromocytoma of the adrenal gland.
abstract: Adrenal pheochromocytomas are rare catecholamine-secreting tumors that originate from chromaffin cells in the adrenal medulla, and giant pheochromocytomas with cystic changes are particularly rare. We report a case of a 46-year-old man who presented with episodic hypertension and headache. Radiographic studies showed an 18-cm cystic mass in the left upper quadrant of the abdomen; further workups, which included light microscopy, immunohistochemical, and electron microscopic analysis, revealed a pheochromocytoma of the left adrenal gland. Cytogenetic analysis and genetic mutation analyses for von-Hippel-Lindau (VHL), rearranged during transfection (RET), and succinate dehydrogenase complex subunit B (SDHB) genes were also performed but failed to reveal any abnormalities within the tumor cells.
authors.affiliation: Department of Pathology, Creighton University Medical Center, 601 N. 30th Street, Omaha, NE 68131, USA.
authors.forename: Zenggang
authors.initials: Z
authors.lastname: Pan
authors.forename: Susan
authors.initials: S
authors.lastname: Repertinger
authors.forename: Caishu
authors.initials: C
authors.lastname: Deng
authors.forename: Poonam
authors.initials: P
authors.lastname: Sharma
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D004252:DNA Mutational Analysis; D006261:Headache / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016612:Paraffin Embedding; D010673:Pheochromocytoma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D016707:Tissue Fixation; D014057:Tomography, X-Ray Computed