[Chronic intestinal pseudo-obstruction and anti-Hu syndrome: 13 years of follow-up without neoplasia].
Chronic intestinal pseudo-obstruction (CIPO) is a heterogeneous group of rare disorders characterised by symptoms of intestinal obstruction with no mechanical evidence of obstruction. It is caused by ineffective intestinal contractions due to visceral neuropathy and/or neuropathy. In adults, CIPO is mostly secondary. The most common causes are metabolic disorders, connective tissue disorders, neuropathic drug related injuries, paraneoplasic and post-infectious syndromes and amyloidosis. Secondary forms of CIPO have been reported with anti-Hu antibodies. This corresponds to an antineuronal antibody that recognizes a protein expressed in the nuclei of neuron (ANNA-1) and neoplasic cells. The anti-Hu antibody must be searched for in patients over 40 years old with CIPO (associated with small cell lung cancer in 75% of cases). Recently, the association of CIPO and the anti-Hu antibody has been described without associated neoplasia. We report a case of an association of CIPO and anti-Hu antibody without cancer after 13 years of follow-up.
Amiot
A
A
Pôle des maladies de l'appareil digestif, service de gastroentérologie et d'assistance nutritive, hôpital Beaujon, 100, boulevard du Général-Leclerc, 92110 Clichy, France.
Joly
F
F
Messing
B
B
Sokol
H
H
Lavergne-Slove
A
A
Delattre
J-Y
JY
Bouhnik
Y
Y
D000906:Antibodies / Q000032:analysis; D002908:Chronic Disease; D051959:ELAV Proteins / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005725:Ganglia, Autonomic / Q000473:pathology; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D009197:Myenteric Plexus / Q000473:pathology; D013577:Syndrome
D000906:Antibodies; D051959:ELAV Proteins