title: Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection.
abstract: Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
authors.affiliation: Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong Seodaemoon-ku, Seoul, Republic of Korea.
authors.forename: Jaemoon
authors.initials: J
authors.lastname: Yang
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Lim
authors.forename: Hong Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Joseph
authors.initials: J
authors.lastname: Park
authors.forename: Sang Cheon
authors.initials: SC
authors.lastname: Lee
authors.forename: Kwangyeol
authors.initials: K
authors.lastname: Lee
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
authors.forename: Seungjoo
authors.initials: S
authors.lastname: Haam
mesh_terms: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D045744:Cell Line, Tumor; D000068818:Cetuximab; D004847:Epithelial Cells / Q000473:pathology*; D066246:ErbB Receptors; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D006801:Humans; D008279:Magnetic Resonance Imaging; D008856:Microscopy, Fluorescence; D053758:Nanoparticles; D011091:Polyesters / Q000138:chemical synthesis; D011109:Polymethacrylic Acids / Q000138:chemical synthesis; D011721:Pyrenes / Q000138:chemical synthesis
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005456:Fluorescent Dyes; D011091:Polyesters; D011109:Polymethacrylic Acids; D011721:Pyrenes; C016240:polycaprolactone; D066246:ErbB Receptors; D000068818:Cetuximab