[Method and meaning research on skin-test of four injections of traditional Chinese medicine].
Huangqi powder injection's positive rate of skin-test was 12.3%. Qingkailing powder injection was 3.0%. Qingkailing injection was 7.6%. Shuanghuanglian injection was 6.3%. Penicillin's rate of allergic reactions was 0.7%-10%. Different form of a drug (power or injection) and different drug consistency could influence the positive rate of skin-test. We don't use drug in positive group, and we use drug in negative group. Some trial subjects still happened allergic reactions in negative group of skin-test. In negative group of skin-test, Huangqi power injection's rate of allergic reactions was 2.1%. Qingkailing injection was 0.4%. Shuanghuanglian injection was 0.9%-2.6%. Shuanghuanglian injection's rate of allergic reactions was 8.6% in all subjects (31/360 include the subjects with positive skin-test and allergic reactions). Qingkailing powder injection's rate of allergic reactions was 4.5% (6/132). Qingkailing injection' s rate of allergic reactions was 9.1% (12/132). Huangqi power injection's rate of allergic reactions was 15.4% (62/402). The total rate of allergic reactions was 10.8%. The main appearance of Penicillin's skin-test was welling under skin, and with some blush. But the main appearance of traditional Chinese medicine skin-test was blush, and with a little welling under skin. Skin-test can reduce the allergic reactions of Qingkailing powder injection, Shuanghuangiian injection, Huangqi power injection. It can be the one measure of reducing adverse reactions.
Weng
Wei-Liang
WL
Xiyuan Hospital, Academy of Chinese Medical Science, Beijing 100091, China. ww6486@126.com
Lin
Hong-Sheng
HS
Gao
Rui
R
Chen
Chang-Huai
CH
D027885:Astragalus propinquus / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D006801:Humans; D008516:Medicine, Chinese Traditional; D011134:Polysaccharides / Q000009:adverse effects* / Q000302:isolation & purification; D012882:Skin Tests
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; C504928:Qingkailing; C516400:shuang-huang-lian