title: Antimicrobial and antileishmanial xanthones from the stem bark of Allanblackia gabonensis (Guttiferae).
abstract: The phytochemical study of stem bark of Allanblackia gabonensis has resulted in the isolation and characterisation of one new xanthone derivative, named allanxanthone D, together with 10 known compounds, including 6 xanthones derivatives, allanxanthone A, 1,5-dihydroxyxanthone, 1,7-dihydroxyxanthone and 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)xanthone, forbexanthone, 6-deoxyisojacareubin, one polyisoprenylated benzophenone, guttiferone F, one flavanol, epicathechin, two phytosterols, beta-sitosterol and campesterol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and hetero-nuclear evidence. These compounds were evaluated for their activity against Leishmania amazonensis in vitro and antimicrobial activities against a range of Gram negative and Gram positive bacteria.
authors.affiliation: Faculty of Science, Department of Chemistry, University of Douala, Douala-Cameroon. azebaze@yahoo.com
authors.forename: A G B
authors.initials: AG
authors.lastname: Azebaze
authors.forename: B M W
authors.initials: BM
authors.lastname: Ouahouo
authors.forename: J C
authors.initials: JC
authors.lastname: Vardamides
authors.forename: A
authors.initials: A
authors.lastname: Valentin
authors.forename: V
authors.initials: V
authors.lastname: Kuete
authors.forename: L
authors.initials: L
authors.lastname: Acebey
authors.forename: V P
authors.initials: VP
authors.lastname: Beng
authors.forename: A E
authors.initials: AE
authors.lastname: Nkengfack
authors.forename: M
authors.initials: M
authors.lastname: Meyer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000981:Antiprotozoal Agents