title: The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study.
abstract: OBJECTIVE
  The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women.
  
  
  METHODS
  Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment.
  
  
  RESULTS
  Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin.
  
  
  CONCLUSIONS
  Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.
authors.affiliation: Departments of Obstetrics and Gynecology, Izmir Training and Research Hospital, Izmir, Turkey. drigulhan@yahoo.com
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Gulhan
authors.forename: Sibel
authors.initials: S
authors.lastname: Bilgili
authors.forename: Rezzan
authors.initials: R
authors.lastname: Gunaydin
authors.forename: Sibel
authors.initials: S
authors.lastname: Gulhan
authors.forename: Cemal
authors.initials: C
authors.lastname: Posaci
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000188:drug therapy; D011446:Prospective Studies; D013876:Thiophenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D020738:Leptin; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D015675:Osteocalcin; D007334:Insulin-Like Growth Factor I