Clinical outcomes after treatment of intra-bony defects with an EMD/synthetic bone graft or EMD alone: a multicentre randomized-controlled clinical trial.
OBJECTIVE
Comparison of the outcomes of a combination of an enamel matrix derivative and a synthetic bone graft (EMD/SBC) with EMD alone in wide intra-bony defects.


METHODS
Seventy-three patients with chronic periodontitis were recruited in five centres in Germany. All patients had one wide intra-bony defect of >/=4 mm. Surgical procedures involved microsurgical technique and the modified papilla preservation flap. After debridement, defects were randomly assigned to EMD/SBC (test) or EMD (control). Assessments at baseline and after 6 months included bone sounding, attachment levels, probing pocket depths, bleeding on probing and recessions. Early wound-healing, adverse effects and patients' perceptions were also recorded.


RESULTS
Both treatment modalities led to significant clinical improvements. Change in bone fill 6 months after surgery was 2.0 mm (+/- 2.1) in the test group and 2.1 mm (+/- 1.2) in the control group. A gain in clinical attachment of 1.3 mm (+/- 1.8) in the test group and 1.8 mm (+/- 1.6) in the control group was observed. One week after surgery, primary closure was maintained in 95% of the test sites and 100% of the control sites. No differences in patients' perceptions were found.


CONCLUSIONS
The results of the present study showed similar clinical outcomes following both treatment modalities.
Jepsen
S
S
Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Germany. jepsen@uni-bonn.de
Topoll
H
H
Rengers
H
H
Heinz
B
B
Teich
M
M
Hoffmann
T
T
Al-Machot
E
E
Meyle
J
J
Jervøe-Storm
P-M
PM
D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates; D002908:Chronic Disease; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D017886:Durapatite; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy / Q000601:surgery; D016896:Treatment Outcome
D018786:Bone Substitutes; D002130:Calcium Phosphates; D003746:Dental Enamel Proteins; C485817:beta-tricalcium phosphate; C109069:enamel matrix proteins; D017886:Durapatite