title: Pregnancy, obstetric and neonatal outcome after assisted reproduction in Nigerians.
abstract: OBJECTIVE
  To evaluate the pregnancy, obstetric and neonatal outcome after assisted reproduction in Nigerians.
  
  
  METHODS
  Case control study of all confirmed pregnancies following assisted reproduction managed at the Havana Specialist Hospital (HSH), Lagos over a 7 year period.
  
  
  RESULTS
  Adverse obstetric and neonatal outcome occurred in 30.8% of pregnancy following assisted reproduction compared to 12.6% in spontaneously conceived pregnancy (p = 0.0003). Multiple pregnancy (<0.001), preterm delivery (p < 0.000), placenta praevia (0.00002), antenatal admission (0.02), early pregnancy bleeding (0.04), miscarriage (0.001) and caesarean delivery (<0.001) were significantly commoner in the assisted reproduction group. After adjustment for confounding variables, preterm delivery (OR: 5.95), miscarriage (OR: 5.84), multiple pregnancy (OR: 4.58), placenta praevia (OR: 4.13), caesarean delivery (OR: 3.57), early pregnancy bleeding (OR: 2.18) and antenatal admission (OR: 2.01) retained their significance.
  
  
  CONCLUSIONS
  This study has provided the first evidence from our part of the world showing that assisted pregnancy is associated with poorer obstetric outcome when compared with spontaneously conceived pregnancy.
authors.affiliation: Clinical Sciences Division, Nigeria Institute of Medical Research, Lagos, Nigeria. oezechi@Yahoo.co.uk
authors.forename: O C
authors.initials: OC
authors.lastname: Ezechi
authors.forename: V I
authors.initials: VI
authors.lastname: Ndububa
authors.forename: O M
authors.initials: OM
authors.lastname: Loto
authors.forename: P M
authors.initials: PM
authors.lastname: Ezeobi
authors.forename: B K E
authors.initials: BK
authors.lastname: Kalu
authors.forename: O F
authors.initials: OF
authors.lastname: Njokanma
authors.forename: C A
authors.initials: CA
authors.lastname: Nwokoro
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009549:Nigeria / Q000453:epidemiology; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology*; D011256:Pregnancy Outcome / Q000453:epidemiology; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*