title: Problems in three Japanese drug users with Human Immunodeficiency Virus infection.
abstract: Numbers of individuals infected with Human Immunodeficiency Virus (HIV) are increasing in Japan. The majority of them are Men who have sex with men and a part of them take drugs as 'Sex drug' at their sexual intercourse. Especially, Amyl nitrite, Methamphetamine, 5-methoxy-N, N-diisopropyltryptamine (5-MeO-DIPT; Foxy), and 3, 4-methylenedioxy- methamphetamine (MDMA; Ecstasy) are used, and they sometimes cause the physical and mental disorders. However, the actual drug inducing troubles among Japanese HIV-infected drug users had not yet been discussed enough. In this report, we describe three cases with HIV infection; a case developed severe neuroleptic malignant syndrome (NMS) after taking 5-MeO-DIPT, a case with persistent convulsion due to multiple drug intake and a case with rhabdomyolysis due to the non-subjective methamphetamine intake. Through these cases, we raise and discuss several underlying problems associated with drug use among HIV-infected individuals.
authors.affiliation: Department of Pharmacy, Osaka National Hospital, National Hospital Organization, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuwahara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakakura
authors.forename: Sachiko
authors.initials: S
authors.lastname: Oda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mori
authors.forename: Tomoko
authors.initials: T
authors.lastname: Uehira
authors.forename: Gaku
authors.initials: G
authors.lastname: Okamoto
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yoshino
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sasakawa
authors.forename: Keishiro
authors.initials: K
authors.lastname: Yajima
authors.forename: Aiko
authors.initials: A
authors.lastname: Umemoto
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Takada
authors.forename: Toshio
authors.initials: T
authors.lastname: Makie
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D008735:5-Methoxytryptamine / Q000009:adverse effects / Q000031:analogs & derivatives; D000328:Adult; D000680:Amyl Nitrite / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active; D044466:Asian People; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D012206:Rhabdomyolysis / Q000209:etiology*; D012640:Seizures / Q000209:etiology*; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: C033696:5-methoxy-N,N-diisopropyltryptamine; D008735:5-Methoxytryptamine; D008694:Methamphetamine; D000680:Amyl Nitrite; D018817:N-Methyl-3,4-methylenedioxyamphetamine