title: Azithromycin: a new therapeutical strategy for acne in adolescents.
abstract: OBJECTIVE
  To study the efficacy, safety, and compliance of 500 mg azithromycin thrice weekly for 8 weeks to treat acne vulgaris in adolescents.
  
  
  METHODS
  An open-label, non-comparative study was carried out for 8 weeks. Fifty-two teenagers with moderate to severe papulo-pustular acne vulgaris were enrolled. Azithromycin, 500 mg orally thrice weekly for 8 weeks, was prescribed. No topical treatment was permitted. At the baseline visit, patients were scheduled to return at two-weekly intervals for 8 weeks. Efficacy was gauged by the percentage clearance of papulo-pustular acne lesions. All patients were also evaluated at four months post-treatment.
  
  
  RESULTS
  A majority of patients (47/52) showed remarkable improvement in the first 4 weeks with a more than 20 percent reduction of their inflammatory papulo-pustular lesions. Maximum clearance was observed in 32 patients at 8 weeks. Slow improvement with eruptions of new lesions was seen in 6 patients. Adverse events, such as heartburn and nausea, were reported by 3 patients. All patients completed the 8-week study period. The beneficial effect was maintained at 4 months after the conclusion of treatment.
  
  
  CONCLUSIONS
  Azithromycin, 500 mg thrice weekly for 8 weeks, appears to be a safe and effective treatment for acne vulgaris in adolescents, with excellent patient compliance.
authors.affiliation: Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology,University of Bologna, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Bardazzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Savoia
authors.forename: Gianluca
authors.initials: G
authors.lastname: Parente
authors.forename: Michela
authors.initials: M
authors.lastname: Tabanelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Balestri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spadola
authors.forename: Emi
authors.initials: E
authors.lastname: Dika
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin