title: Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis.
abstract: We used Fgf10-lacZ reporter mice to investigate the distribution and fate of Fgf10-expressing cells in the developing and adult mouse brain. We find that the domain of Fgf10 expression expands post-natally and new niches emerge in the adult brain. Fgf10 is expressed in the adult cerebellum, thalamic, mid- and hindbrain nuclei and hippocampal CA fields, as previously reported in the rat brain. In addition though, we have discovered expression in: the hippocampal dentate gyrus; a discrete trail linking the ventral telencephalon with the olfactory bulbs; ventral ependyma of the third ventricle from where cells appear to disperse into the hypothalamus; and in the pituitary gland. Most Fgf10-expressing cells or their immediate descendants appear immature but a subset differentiates into neurons and glial cells. The manner in which Fgf10 is expressed in these active and quiescent neurogenic niches implicates it in control of neurogenesis and/or conservation of neurogenic potential.
authors.affiliation: School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK. m.k.h@uea.ac.uk
authors.forename: Mohammad K
authors.initials: MK
authors.lastname: Hajihosseini
authors.forename: Stijn
authors.initials: S
authors.lastname: De Langhe
authors.forename: Eva
authors.initials: E
authors.lastname: Lana-Elola
authors.forename: Harris
authors.initials: H
authors.lastname: Morrison
authors.forename: Neil
authors.initials: N
authors.lastname: Sparshott
authors.forename: Robert
authors.initials: R
authors.lastname: Kelly
authors.forename: James
authors.initials: J
authors.lastname: Sharpe
authors.forename: David
authors.initials: D
authors.lastname: Rice
authors.forename: Saverio
authors.initials: S
authors.lastname: Bellusci
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development*; D002454:Cell Differentiation / Q000502:physiology*; D051526:Fibroblast Growth Factor 10 / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000502:physiology*
chemical_list: C496464:Fgf10 protein, mouse; D051526:Fibroblast Growth Factor 10