title: Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement.
abstract: Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polyester with rubber-like properties. Introduction of this polymer into an injectable calcium phosphate bone cement can therefore be used to introduce macroporosity into the cement for tissue engineering purposes as well as to improve mechanical properties. Aim of this study was to investigate calcium phosphate cements with incorporated PTMC microspheres (PTMC CPCs) on their physical/mechanical properties and in vitro degradation characteristics. Therefore, composites were tested on setting time and mechanical strength as well as subjected to phosphate buffered saline (PBS) and enzyme containing medium. PTMC CPCs (12.5 and 25 wt%) with molecular weights of 52.7 kg mol(-1) and 176.2 kg mol(-1) were prepared, which showed initial setting times similar to that of original CPC. Though compression strength decreased upon incorporation of PTMC microspheres, elastic properties were improved as strain-at-yield increased with increasing content of microspheres. Sustained degradation of the microspheres inside PTMC CPC occurred when incubated in the enzymatic environment, but not in PBS, which resulted in an interconnected macroporosity for the 25 wt% composites.
authors.affiliation: Department of Periodontology and Biomaterials, College of Dental Science, Radboud University, Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Wouter J E M
authors.initials: WJ
authors.lastname: Habraken
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Joop G C
authors.initials: JG
authors.lastname: Wolke
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Grijpma
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
authors.forename: Jan
authors.initials: J
authors.lastname: Feijen
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D020341:Absorbable Implants; D001696:Biomechanical Phenomena; D001843:Bone Cements / Q000138:chemical synthesis / Q000378:metabolism*; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000378:metabolism*; D019245:Compressive Strength; D004146:Dioxanes / Q000138:chemical synthesis / Q000378:metabolism*; D004548:Elasticity; D008049:Lipase / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism*; D016062:Porosity
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D004146:Dioxanes; D011108:Polymers; C059299:polytrimethylene carbonate; C020243:calcium phosphate; D008049:Lipase