[Pineal melatonin exhibits more pronounced antistressor properties than anxiolytic diazepam].
The pineal hormone melatonin (0.1 mg/kg) produced a more pronounced antistressor effect as compared to the anxiolytic diazepam (same dose) in rats, which was manifested by decreased anxiety, improved heart rhythm variability, and prevented stress-induced violation of circadian locomotion. It is suggested that differences may result from more expressed hormonal chronotropic activity of melatonin.
Arushanian
E B
EB
Beĭer
E V
EV
Bulgakova
A S
AS
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*
D014151:Anti-Anxiety Agents; D008550:Melatonin; D003975:Diazepam