Purine-containing cucurbitane triterpenoids from Cucurbita pepo cv dayangua.
Phytochemical investigation of the fruits of Cucurbita pepo cv dayangua led to the isolation of cucurbitaglycosides A (1) and B (2). This is the first report of cucurbitane triterpenoids with a purine unit. Their structures were elucidated mainly based on interpretation of HRESIMS results, as well as 1D and 2D NMR spectra. Cucurbitaglycosides A and B showed cytotoxic activity against the human epithelial carcinoma cell line HeLa with IC50 of 17.2 and 28.4 microg/mL, respectively.
Wang
Da-Cheng
DC
School of Veterinary Science, Jilin University, Jilin 130062, China.
Xiang
Hua
H
Li
Dan
D
Gao
Hui-Yuan
HY
Cai
Hui
H
Wu
Li-Jun
LJ
Deng
Xu-Ming
XM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D028464:Cucurbita / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011687:Purines / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D011687:Purines; D014315:Triterpenes; C514277:cucurbitane