title: Brianodins A-D, briarane-type diterpenoids from soft coral Pachyclavularia sp.
abstract: Four new briarane-type diterpenoids, brianodins A-D ( 1- 4), were isolated from a soft coral, Pachyclavularia sp., and the structures and relative stereochemistry of 1- 4 were elucidated on the basis of spectroscopic data. The absolute configurations of 3 and 4 were assigned by the MTPA method. Brianodin A ( 1) showed a modest cytotoxicity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ishiyama
authors.forename: Taro
authors.initials: T
authors.lastname: Okubo
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yasuda
authors.forename: Yohei
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Iguchi
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes