title: Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice.
abstract: The hypoglycemic effects of Eriobotrya japonica seeds were investigated in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and KK-A(y) mice. The rats and mice were fed on a diet containing 10% powdered Eriobotrya japonica seeds with the coat intact for 4 months. Although the blood glucose concentration in the OLETF rats fed on the control diet without Eriobotrya japonica seeds was increased with time, the concentration in the OLETF rats fed on the diet with Eriobotrya japonica seeds was consistently low throughout the experimental period and was comparable to the level in Long-Evans Tokushima Otsuka (LETO) rats which are normal non-diabetic rats. Serum insulin was significantly lower in the OLETF rats fed on the Eriobotrya japonica seed diet than in those fed on the control diet at the termination of the experimental period. Eriobotrya japonica seeds suppressed the increment of blood glucose for 4 months and also effectively improved the glucose tolerance in the KK-A(y) mice, these actions being mainly exerted by the ethanol extract of the seeds. These results suggest that Eriobotrya japonica seeds had a hypoglycemic property and the effect is attributable to the components extracted by ethanol.
authors.affiliation: Graduate School of Human Health Science, Siebold University of Nagasaki, 1-1-1 Manabino, Nishisonogi-gun, Nagasaki 851-2195, Japan. katanaka@sun.ac.jp
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shoko
authors.initials: S
authors.lastname: Nishizono
authors.forename: Nozomi
authors.initials: N
authors.lastname: Makino
authors.forename: Shizuka
authors.initials: S
authors.lastname: Tamaru
authors.forename: Osamu
authors.initials: O
authors.lastname: Terai
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D031983:Eriobotrya / Q000737:chemistry*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012639:Seeds
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts