title: Intracranial recurrence and distant metastasis of scalp dermatofibrosarcoma protuberans.
abstract: Only few cases of scalp dermatofibrosarcoma protuberans with intracranial and distant metastasis have been reported. Here we report a case of scalp dermatofibrosarcoma protuberans with frequent local recurrence, intracranial invasion and with distant lung metastasis during 6 years of treatment. We would like to emphasize difficulties in surgical treatment of such invasive and locally recurrent tumors of scalp, and necessity to understand new molecular pathogenesis of dermatofibrosarcoma protuberans and potential treatment strategy with imatinib for patients with surgically untreatable disease. Close surveillance of patients with scalp dermatofibrosarcoma is necessary due recurrence nature of tumor.
authors.affiliation: Department of Neurosurgery, University hospital Dubrava, Av. G. Suska 6, Zagreb, Croatia.
authors.forename: Jurica
authors.initials: J
authors.lastname: Marakovic
authors.forename: Milorad
authors.initials: M
authors.lastname: Vilendecic
authors.forename: Tonko
authors.initials: T
authors.lastname: Marinovic
authors.forename: Smiljka
authors.initials: S
authors.lastname: Lambasa
authors.forename: Gordan
authors.initials: G
authors.lastname: Grahovac
mesh_terms: D000328:Adult; D018223:Dermatofibrosarcoma / Q000556:secondary*; D017809:Fatal Outcome; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D012535:Scalp / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery