WITHDRAWN: Use of PSA-NCAM in Repair of the Central Nervous System.
Polysialic acid (PSA) is a highly hydrated polymer whose presence at the cell surface can reduce cell interactions, and thereby increase tissue and cellular plasticity. Given its ability to create a permissive environment for cell migration and axonal growth, the potential of engineered over-expression of PSA to promote tissue repair has been explored in the adult CNS. Several promising results have been obtained that suggest that PSA engineering may become a valuable therapeutic tool.
El Maarouf
Abderrahman
A
Department of Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA, a-el-maarouf@ski.mskcc.org.
Rutishauser
Urs
U