title: Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa.
abstract: Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing, China. drijaz_chem@yahoo.com
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Shilin
authors.initials: S
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Peng
authors.forename: Sibao
authors.initials: S
authors.lastname: Chen
authors.forename: Lijia
authors.initials: L
authors.lastname: Xu
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032861:Buddleja; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008958:Models, Molecular; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D039823:Iridoids; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase