title: [Morbidity of adult contacting persons in the family foci of tuberculosis and impact of aggravating factors].
abstract: Eighty-three foci of infection were studied in 2 communities of Yerevan (a study group) in which of 279 contact persons, 117 (40.2%) adult family members had fallen ill over 10 years (1995-2005); of them there were 61 (32.5%) persons, with 2 and 3 subjects in 20 and 7 (only type 1 foci) foci, respectively. There was a preponderance of type 1 foci that were most unfavorable in infection massiveness and hygiene and sanitary conditions, in which the largest number of contacting persons (62.4%) had been fallen. Among the sources of infection, males (84.3%), able-bodied (aged 31-50 years) (47%), and patients with destructive bacterial forms of pulmonary tuberculosis (85.55%) were prevalent; 19.3% isolated drug-resistant Mycobacterium tuberculosis (MBT) strains and 20.4% died. All the above aggravating factors were significantly more frequently encountered in than in the control group comprising 50 foci with 110 family members and none case of the disease (p < 0.05). Among the diseased contacting persons, the young (18-30-year-old) (43.6%) and able-bodied (40.2%) were predominant. Sex-specific differences were not established. Out of the clinical forms, infiltrative and focal foci prevailed. The disease was detected in 62.4% following 6 months or more and in the remaining with a better pattern in the earlier period (within 1 to 6 months), which shows it necessary to reduce the time of a follow-up from 6 to 3 months. Identification of 13.7% of the contacting persons simultaneously with the source of infection requires that detection of latent foci of infection should be improved.
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Petrosian
authors.forename: E P
authors.initials: EP
authors.lastname: Stamboltsian
authors.forename: M A
authors.initials: MA
authors.lastname: Mkrtchian
authors.forename: G R
authors.initials: GR
authors.lastname: Markarian
mesh_terms: D000293:Adolescent; D000328:Adult; D001136:Armenia / Q000453:epidemiology; D002391:Catchment Area, Health; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000635:transmission*