title: One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of alpha-bromoacetate, malononitrile and aromatic aldehydes.
abstract: Polysubstituted benzene derivatives with an unprecedented substitution pattern are produced in a novel one-pot multi-component cyclization reaction from pyridine, ethyl alpha-bromoacetate, malononitrile and aromatic aldehyde in refluxing acetonitrile.
authors.affiliation: College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China. cgyan@yzu.edu.cn
authors.forename: Chao Guo
authors.initials: CG
authors.lastname: Yan
authors.forename: Xiao Kai
authors.initials: XK
authors.lastname: Song
authors.forename: Qi Fang
authors.initials: QF
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Ulrich
authors.initials: U
authors.lastname: Siemeling
authors.forename: Clemens
authors.initials: C
authors.lastname: Bruhn
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000085:Acetates; D000447:Aldehydes; D001555:Benzene Derivatives; D009570:Nitriles; C016274:bromoacetate; C000945:dicyanmethane