title: Severe drug hypersensitivity reaction in a young woman treated with doxycycline.
abstract: Doxycycline is a commonly prescribed medication for the management of acne vulgaris. Severe adverse reactions to this medication are uncommon. We describe an unusual case of a 20-year-old female who experienced a life-threatening hypersensitivity reaction, including fever, lymphadenopathy, hepatitis, nephritis and severe pneumonitis with respiratory failure following oral administration of doxycycline for facial acne.
authors.affiliation: Department of Medicine, Division of Dermatology, University of Washington Medical Center, Seattle, Washington 98105-6524 , USA. drobles@u.washington.edu
authors.forename: David T
authors.initials: DT
authors.lastname: Robles
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Leonard
authors.forename: Nicholas
authors.initials: N
authors.lastname: Compton
authors.forename: Alpana
authors.initials: A
authors.lastname: Waghmare
authors.forename: Karen A
authors.initials: KA
authors.lastname: McDonough
authors.forename: Evan
authors.initials: E
authors.lastname: George
authors.forename: Greg
authors.initials: G
authors.lastname: Wolgamot
authors.forename: Philip
authors.initials: P
authors.lastname: Fleckman
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004318:Doxycycline / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D004487:Edema / Q000473:pathology; D004802:Eosinophilia / Q000139:chemically induced; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced; D009393:Nephritis / Q000139:chemically induced*; D011014:Pneumonia / Q000139:chemically induced*; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012867:Skin / Q000473:pathology; D013577:Syndrome
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline