title: alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.
abstract: Two new triterpenoids, 18alpha,19beta-20(30)-taraxasten-3beta,21alpha-diol (cichoridiol) (1) and 17-epi-methyl-6-hydroxyangolensate (intybusoloid) (2), were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, lupeol (3), friedelin (4), beta-sitosterol (5), stigmasterol (6), betulinic acid (7), betulin (8), betulinaldehyde (9), syringic acid (10), vanillic acid (11) 6,7-dihydroxycoumarin (12), and methyl-alpha-D-galactopyranoside (13). Compounds 1, 1a, and 11 showed a good alpha-glucosidase inhibitory activity.
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
authors.lastname: Atta-ur-Rahman
authors.forename: Seema
authors.initials: S
authors.lastname: Zareen
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: M Nadeem
authors.initials: MN
authors.lastname: Akhtar
authors.forename: Shamsun Nahar
authors.initials: SN
authors.lastname: Khan
mesh_terms: D018651:Cichorium intybus / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D010946:Plants, Medicinal / Q000737:chemistry*; D012440:Saccharomyces / Q000201:enzymology; D012639:Seeds / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000378:metabolism; D000094062:Betulinic Acid; D000094042:Lupanes
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000520:alpha-Glucosidases; C530244:cichoridiol; C530243:intybusoloid; C002503:betulin; D000094062:Betulinic Acid; C060796:friedelin; D000094042:Lupanes; C010480:lupeol