Antidepressant-like effect of asiaticoside in mice.
In the present study, the potential antidepressant properties of asiaticoside were investigated in male mice in three tests -- splash test in the unpredictable chronic mild stress (CMS) model, tail suspension test (TST), forced swimming test (FST) -- with clomipramine being a positive control. In the splash test, asiaticoside (10 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly augmented the frequency of grooming behavior in stressed mice. In the tail suspension test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. In the forced swimming test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. These results suggest that asiaticoside may have antidepressant-like action.
Liang
Xin
X
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.
Yan Ni Huang
Si Wei Chen
Wen Juan Wang
Xu
Na
N
Cui
Shan
S
Liu
Xing Hua
XH
Zhang
Hua
H
Yue Nan Liu
Liu
Shuang
S
Yang
Ming
M
Dong
Yan
Y
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013550:Swimming; D014315:Triterpenes / Q000494:pharmacology*
D000928:Antidepressive Agents; D014315:Triterpenes; D002997:Clomipramine; C004446:asiaticoside