Interfering with extracellular matrix degradation to blunt inflammation.
Chemoattractant properties of matrix proteins, like collagen and elastin, for neutrophils and monocytes in vitro have long been recognized. This activity often resides in fragments of these proteins. These peptides may play a role in diseases of the lung matrix, such as chronic obstructive pulmonary disease. Recent advances include the elucidation of the structure of chemotactic collagen fragments and the demonstration that their activity may reside in a structural relatedness to CXC chemokines. Collagen and elastin fragments have been demonstrated to have a role in in vivo lung pathophysiology and have been quantified in patients with chronic lung diseases where they may activate autoimmune pathways. Elucidation of these pathways may provide novel biomarkers and therapeutic targets for chronic lung diseases.
O'Reilly
Philip J
PJ
Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, THT 442, 1530 3rd Avenue South, Birmingham, AL 35294-0006, United States. poreilly@uab.edu
Gaggar
Amit
A
Blalock
J Edwin
JE
D000818:Animals; D019743:Chemokines, CXC / Q000737:chemistry; D002630:Chemotactic Factors / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000188:drug therapy*; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D009842:Oligopeptides / Q000096:biosynthesis / Q000737:chemistry; D010446:Peptide Fragments / Q000378:metabolism; D010447:Peptide Hydrolases / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy
D019743:Chemokines, CXC; D002630:Chemotactic Factors; D016326:Extracellular Matrix Proteins; C428643:N-acetyl-proline-glycine-proline; D009842:Oligopeptides; D010446:Peptide Fragments; D003094:Collagen; D004549:Elastin; D010447:Peptide Hydrolases; D020780:Matrix Metalloproteinase 9