title: The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma.
abstract: BACKGROUND
  In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis.
  
  
  METHODS
  An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed.
  
  
  RESULTS
  Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination.
  
  
  CONCLUSIONS
  Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.
authors.affiliation: Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Charles
authors.initials: C
authors.lastname: Woodall
authors.forename: John M
authors.initials: JM
authors.lastname: Wo
authors.forename: Huaiyu
authors.initials: H
authors.lastname: Zheng
authors.forename: Chin K
authors.initials: CK
authors.lastname: Ng
authors.forename: Mukunda B
authors.initials: MB
authors.lastname: Ray
authors.forename: Robert C
authors.initials: RC
authors.lastname: Martin
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001471:Barrett Esophagus / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000473:pathology*; D019788:Fluorodeoxyglucose F18; D007150:Immunohistochemistry; D008679:Metaplasia / Q000473:pathology; D049268:Positron-Emission Tomography; D011230:Precancerous Conditions / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D019788:Fluorodeoxyglucose F18