[Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines].
To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats. The absorption of the drug conforms to the firt-order kinetics and passive transport mechanism . The results indicate that paeonol-beta-CD absorption mechanism wasn't change.
Hu
Rong-Feng
RF
Department of Pharmaceutics, Anhui College of Traditional Chinese Medicine, Hefei 230038, China. hurongfeng@163.com
Fang
Cheng-Wu
CW
Zou
Ai-Feng
AF
Mei
Kang-Kang
KK
Tang
Ji-Hui
JH
Han
Ling-Ling
LL
D000098:Acetophenones / Q000493:pharmacokinetics*; D000818:Animals; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000098:Acetophenones; C013638:paeonol