Thymus lineage commitment: a single switch.
In this issue of Immunity, He et al. (2008) establish the logic and circuitry that determine CD4-CD8 lineage specification. It all comes down to an eighty base pair silencer switch.
Hedrick
Stephen M
SM
University of California, San Diego, La Jolla, CA 92093-0377, USA. shedrick@ucsd.edu
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D006801:Humans; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology