title: Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate.
abstract: Herein we report the 1.15 A X-ray crystal structure of a short alpha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived alpha-helix truly resembles the structure of canonical alpha-helices and provides unequivocal support for our helix nucleation strategy.
authors.affiliation: Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Deyun
authors.initials: D
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zheng
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
mesh_terms: D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides