Elevated substance P levels in HIV-infected women in comparison to HIV-negative women.
Substance P and its receptor (neurokinin-1R) are potent modulators of neuroimmunoregulation and HIV/AIDS infection. We previously demonstrated that HIV-seropositive men had significantly higher substance P levels compared to uninfected controls. We now demonstrate that substance P plasma levels are significantly higher in HIV-infected women in comparison to uninfected control women.
Douglas
Steven D
SD
Division of Allergy and Immunology, Department of Pediatrics, Joseph Stokes Jr. Research Institute at the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. DOUGLAS@email.chop.edu
Cnaan
Avital
A
Lynch
Kevin G
KG
Benton
Tami
T
Zhao
Huaqing
H
Gettes
David R
DR
Evans
Dwight L
DL
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D013373:Substance P / Q000097:blood*
D013373:Substance P