The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H1-receptor-PKC-MAPK signalling pathway.
Ales
K
K
Department of Pharmacology and Experimental Toxicology, Ljubljana, Slovenia.
Wraber
B
B
Lipnik-Stangelj
M
M
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011738:Pyrilamine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011969:Receptors, Histamine H1 / Q000378:metabolism*
D004791:Enzyme Inhibitors; D006633:Histamine Antagonists; D015850:Interleukin-6; D011969:Receptors, Histamine H1; D006632:Histamine; D020932:Nerve Growth Factor; D011493:Protein Kinase C; D020928:Mitogen-Activated Protein Kinases; D011738:Pyrilamine