[Beneficial effects of Qiangxin capsule on controlling protein expression of myocardial apoptosis in heart failure rats].
OBJECTIVE
To observe the effects of Qiangxin Capsule on myocardial apoptosis in chronic heart failure rats.


METHODS
The model was established by injecting ADR in intraperitoneal of Wistar rat. The models were devided into three groups those were prvention group with Chinese medicine, treatment group with Chinese medicine and control group with medicine. Cardiac myocyte apoptosis were detected by terminal deoxynucleotidyl transferaseediated dUTP nick-end labeling (TUNEL), Fas and cardiac expression level of Bcl-2 were detected by immunohistochemistry.


RESULTS
Qiangxin capsule could inhibit myocardial apoptosis and Fas protein expression on chronic heart failure rat obviously , and improve Bcl-2 protein expression.


CONCLUSIONS
Qianxin capsule can inhibit myocardial apoptosis and control Fas/Bcl-2 obviously. It may be one of its effects in delaying chronic heart failure.
Chen
Jing
J
Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Cao
Hong-xin
HX
Yang
Hua-sheng
HS
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002214:Capsules; D004317:Doxorubicin; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019014:fas Receptor / Q000096:biosynthesis
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; C530394:qiangxin; D004317:Doxorubicin