title: Effects of extensive splenomegaly in patients with myelofibrosis undergoing a reduced intensity allogeneic stem cell transplantation.
abstract: Changes in spleen size postallogeneic haematopoietic stem cell transplantation (HSCT) in patients with primary myelofibrosis have been poorly characterized. We analysed 10 patients with myelofibrosis and splenomegaly following a reduced-intensity allogeneic HSCT. All patients fully engrafted donor cells including five patients with extensive splenomegaly. Extensive splenomegaly was associated with a prolonged time to neutrophil and platelet recovery. In all 10 patients, a progressive reduction of splenomegaly was documented within 12 months post-transplant and paralleled the reduction of marrow fibrosis. These findings suggest that myelofibrosis patients with extensive splenomegaly may proceed with allogeneic HSCT without prior splenectomy.
authors.affiliation: Department of Medicine, Division of Hematology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Ciurea
authors.forename: Barry
authors.initials: B
authors.lastname: Sadegi
authors.forename: Andrew
authors.initials: A
authors.lastname: Wilbur
authors.forename: Victoria
authors.initials: V
authors.lastname: Alagiozian-Angelova
authors.forename: Sujata
authors.initials: S
authors.lastname: Gaitonde
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Dobogai
authors.forename: Luke P
authors.initials: LP
authors.lastname: Akard
authors.forename: Ronald
authors.initials: R
authors.lastname: Hoffman
authors.forename: Damiano
authors.initials: D
authors.lastname: Rondelli
mesh_terms: D000075202:Contraindications; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D010976:Platelet Count; D055728:Primary Myelofibrosis / Q000150:complications / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D013163:Splenomegaly / Q000097:blood / Q000209:etiology* / Q000473:pathology; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome