[Experimental rationale for a transscleral approach to thermotherapy for intraocular tumors, by using a photosensitizer].
The authors present the results of an experimental study of the pattern of distribution of laser radiation at a wavelength of 810 nm in the normal and Photosens-photosensitized eye tissues and analyze the distribution of a temperature at the sclera/choroidea/ tumor border during transscleral radiation delivery. To further the goal, the authors have resorted to computer mathematical simulation. In convergent-beam radiation supply, the proportion of a scattered radiation component has been ascertained to be lower in the surface scleral layer than that in the layers adjacent to the choroidea and the base of a tumor. On entering the sclera, a splash of light decreases and power density and radiation-induced heating of the deeply located tissues increase. Thus, the major hyperthermic effects show themselves in the tumor rather than on the sclera.
Likhvantseva
V G
VG
Merzliakova
O Iu
OIu
Vereshchagina
M V
MV
Shevchik
S A
SA
Loshchenov
V B
VB
Kuz'min
S G
SG
Vorozhtsov
G N
GN
D003198:Computer Simulation; D005134:Eye Neoplasms / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012590:Sclera; D016896:Treatment Outcome
D017319:Photosensitizing Agents