title: Fibrinolytic inhibitor levels and polymorphisms in Behçet disease and their association with thrombosis.
abstract: This study aimed to assess the fibrinolytic inhibitors and their association with thrombosis in Behçet disease. Thrombin activatable fibrinolysis inhibitor (TAFI) (P < 0.001) and plasminogen activator inhibitor-1 (PAI-1) levels (P = 0.022) were significantly higher in 79 patients than in 84 controls. No significant differences were observed in CPB2 (TAFI) Thr325Ile and SERPINE1 (PAI1) 4G/5G polymorphism distribution between patients and controls. TAFI activity levels were significantly higher in patients with thrombosis than in those without thrombosis (P = 0.024). In conclusion, the increased TAFI levels in Behçet disease could contribute to the increased risk of thrombosis observed in these patients.
authors.affiliation: Dermatology Service, La Fe University Hospital, Valencia, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Ricart
authors.forename: Luis A
authors.initials: LA
authors.lastname: Ramón
authors.forename: Amparo
authors.initials: A
authors.lastname: Vayá
authors.forename: Francisco
authors.initials: F
authors.lastname: España
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Santaolaria
authors.forename: José
authors.initials: J
authors.lastname: Todolí
authors.forename: Remedios
authors.initials: R
authors.lastname: Castelló
authors.forename: Jordi
authors.initials: J
authors.lastname: Fontcuberta
authors.forename: Amparo
authors.initials: A
authors.lastname: Estellés
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D025901:Carboxypeptidase B2 / Q000097:blood*; D005260:Female; D005342:Fibrinolysis; D020022:Genetic Predisposition to Disease; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011110:Polymorphism, Genetic; D013927:Thrombosis / Q000097:blood* / Q000235:genetics
chemical_list: D001786:Blood Glucose; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D025901:Carboxypeptidase B2