title: Potential applications of global protein expression analysis (proteomics) in morbid obesity and bariatric surgery.
abstract: Global protein expression analysis, known as proteomics, has emerged as a novel scientific technology currently successfully applied to several fields of medicine including cancer and transplantation. Thereby, a thorough exploration of the pathogenic mechanisms and a better understanding of the pathophysiology of diseases as well as identification of diagnostic biomarkers have been achieved. In this paper, we outline the basic principles and potential applications of this promising tool in bariatric surgery where proteomics might hold great potential for new insights into diagnostic and therapeutic decision making based on improved knowledge of metabolic regulations pre- and postsurgical interventions in morbidly obese patients.
authors.affiliation: Department of General and Transplant Surgery, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria.
authors.forename: Gerald
authors.initials: G
authors.lastname: Brandacher
authors.forename: Georg
authors.initials: G
authors.lastname: Golderer
authors.forename: Katrin
authors.initials: K
authors.lastname: Kienzl
authors.forename: Ernst R
authors.initials: ER
authors.lastname: Werner
authors.forename: Raimund
authors.initials: R
authors.lastname: Margreiter
authors.forename: Helmut G
authors.initials: HG
authors.lastname: Weiss
mesh_terms: D050110:Bariatric Surgery; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D009767:Obesity, Morbid / Q000150:complications / Q000378:metabolism* / Q000601:surgery*; D040901:Proteomics
chemical_list: D015415:Biomarkers