title: Pentoxifylline to treat radiation proctitis: a small and inconclusive randomised trial.
abstract: This prospective randomised controlled study of 40 patients could not show a statistically significant advantage with 6 months of pentoxifylline compared with standard measures for late radiation-induced rectal bleeding. However, a modest benefit cannot be excluded and larger randomised placebo-controlled trials with longer durations of pentoxifylline treatment may be justified.
authors.affiliation: Academic Urology Unit, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, UK.
authors.forename: R
authors.initials: R
authors.lastname: Venkitaraman
authors.forename: A
authors.initials: A
authors.lastname: Price
authors.forename: J
authors.initials: J
authors.lastname: Coffey
authors.forename: A R
authors.initials: AR
authors.lastname: Norman
authors.forename: F V
authors.initials: FV
authors.lastname: James
authors.forename: R A
authors.initials: RA
authors.lastname: Huddart
authors.forename: A
authors.initials: A
authors.lastname: Horwich
authors.forename: D P
authors.initials: DP
authors.lastname: Dearnaley
mesh_terms: D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy; D006801:Humans; D010431:Pentoxifylline / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011349:Proctitis / Q000188:drug therapy* / Q000209:etiology; D011832:Radiation Injuries / Q000628:therapy*
chemical_list: D010975:Platelet Aggregation Inhibitors; D010431:Pentoxifylline