title: Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers.
abstract: Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement.
authors.affiliation: Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Rene
authors.initials: R
authors.lastname: Sánchez-Vázquez
authors.forename: G
authors.initials: G
authors.lastname: Briseño-Rodríguez
authors.forename: Ernesto German
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Gálvez-Gastélum
authors.forename: Silvia Elena
authors.initials: SE
authors.lastname: Totsuka-Sutto
authors.forename: Leonel
authors.initials: L
authors.lastname: Garcia-Benavides
mesh_terms: D000279:Administration, Cutaneous; D000336:Aerosols; D002196:Capillaries / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D014665:Vasodilator Agents / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000336:Aerosols; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate