Comparison of the preventive activity of isorhamnetin glycosides from atsumi-kabu (red turnip, Brassica, campestris L.) leaves on carbon tetrachloride-induced liver injury in mice.
Isorhamnetin 3-O-glucoside, which was contained together with isorhamnetin 3,7-di-O-glucoside in atsumi-kabu leaves, suppressed increases in the plasma ALT and AST activities of mice with liver injury induced by the injection of carbon tetrachloride, but no suppression by isorhamnetin 3,7-di-O-glucoside was apparent. This result indicates that the release of glucose at the 7-position in isorhamnetin 3,7-di-O-glucoside was very important to mitigating liver injury.
Igarashi
Kiharu
K
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1-23 Wakaba-machi, Tsuruoka-shi, Yamagata 997-8555, Japan. igarashi@tds1.tr.yamagata-u.ac.jp
Mikami
Tsuyoshi
T
Takahashi
Yuri
Y
Sato
Hideyo
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001937:Brassica; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D044948:Flavonols / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008517:Phytotherapy; D018515:Plant Leaves; D013329:Structure-Activity Relationship; D016896:Treatment Outcome
D044948:Flavonols; C432511:isorhamnetin 3-O-glucoside; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase