Preoperative statin intake and morbid events after isolated coronary artery bypass grafting.
OBJECTIVE
To examine the effect of statins on morbidity and mortality in patients after isolated coronary artery bypass grafting (CABG).


METHODS
Observational cohort study.


METHODS
Tertiary-care teaching hospital.


METHODS
Data from 2497 adult patients who underwent isolated CABG between January 2002 and June 2004 were studied. Patient characteristics and intraoperative variables were prospectively collected. End points were major morbid events and in-hospital mortality. A propensity score was estimated for each patient using logistic regression on the probability of statin use. Patients were also classified into 5 quintile groups according to their propensity score. Outcome variables were compared for propensity-matched pairs and quintile groups between those who received and did not receive statin therapy.


RESULTS
Propensity matching resulted in a similar distribution of variables among the 654 matched pairs. Similar perioperative mortality was found between matched pairs with statin therapy vs no statin therapy, 5 (0.76%) and 8 (1.2%), (P = 0.40), respectively. Cardiac, neurologic, renal and respiratory morbidity, occurrence of atrial fibrillation, and length of hospital stay were similar between the matched pairs and among quintiles of propensity scores.


CONCLUSIONS
Preoperative statin intake did not reduce the frequency of major perioperative morbid events after isolated CABG.
Subramaniam
Kathirvel
K
Department of Anesthesiology, UPMC Presbyterian Hospital, Pittsburgh, PA, USA. subramaniamk@upmc.edu
Koch
Colleen Gorman
CG
Bashour
Allen
A
O'Connor
Michael
M
Xu
Meng
M
Gillinov
A Marc
AM
Starr
Norman J
NJ
D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003327:Coronary Disease / Q000188:drug therapy / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007902:Length of Stay; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D012107:Research Design; D012307:Risk Factors; D016896:Treatment Outcome
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors