title: Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats.
abstract: IL-1beta, TNF-alpha, cytokine-induced neutrophil chemoattractant-2alpha/beta, and IL-10 measurements were performed in elicited peritoneal cells from control, diabetic, and insulin-treated diabetic rats. Production/liberation of these cytokines was decreased in elicited peritoneal cells from diabetic rats. These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states.
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil. tatica@icb.usp.br
authors.forename: Tatiana Carolina
authors.initials: TC
authors.lastname: Alba-Loureiro
authors.forename: Tania Cristina
authors.initials: TC
authors.lastname: Pithon-Curi
authors.forename: Rui
authors.initials: R
authors.lastname: Curi
mesh_terms: D000818:Animals; D019743:Chemokines, CXC / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D016753:Interleukin-10 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism; D010537:Peritoneum / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D019743:Chemokines, CXC; C513294:Cxcl3 protein, rat; D016207:Cytokines; D007328:Insulin; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D006003:Glycogen