title: Modulation of genes involved in zinc homeostasis in old low-grade atherosclerotic patients under effects of HMG-CoA reductase inhibitors.
abstract: Taking into account the antioxidant properties of zinc, it is difficult to explain the beneficial effects of HMG-CoA reductase inhibitors in the context of a well-known decreased zinc status. Therefore, intracellular zinc homeostasis was studied in patients with low-grade carotid atherosclerosis under treatment with HMG-CoA reductase inhibitors using a custom microarray-based approach developed by pooling information across microarray studies. Experimental data unravel an active zinc signaling in PBMC from low-grade atherosclerotic patients under lipid reduction therapy, suggesting that monitoring intracellular zinc status could be a key factor for an optimal strategy and targeting a level of intervention.
authors.affiliation: Immunology Center, Section of Nutrition, Immunity and Ageing, Research Department, INRCA, Ancona, Italy. lauracostarelli@hotmail.com
authors.forename: Laura
authors.initials: L
authors.lastname: Costarelli
authors.forename: Elisa
authors.initials: E
authors.lastname: Muti
authors.forename: Marco
authors.initials: M
authors.lastname: Malavolta
authors.forename: Robertina
authors.initials: R
authors.lastname: Giacconi
authors.forename: Catia
authors.initials: C
authors.lastname: Cipriano
authors.forename: Davide
authors.initials: D
authors.lastname: Sartini
authors.forename: Monica
authors.initials: M
authors.lastname: Emanuelli
authors.forename: Mauro
authors.initials: M
authors.lastname: Silvestrini
authors.forename: Leandro
authors.initials: L
authors.lastname: Provinciali
authors.forename: Beatrice
authors.initials: B
authors.lastname: Gobbi
authors.forename: Eugenio
authors.initials: E
authors.lastname: Mocchegiani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D015203:Reproducibility of Results; D015032:Zinc / Q000378:metabolism*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015032:Zinc