Aging and cancer cell biology, 2008.
There is increasing support for the idea that aging and cancer are intimately connected by the activity of specific genes and the cellular responses to potentially oncogenic insults. This Hot Topics review discusses some recently published articles that shed light on both the commonalities--and intricacies--of the cancer-aging relationship. These articles reveal the expected complexities, but also surprising conservation, in mechanisms that link cancer and aging.
Campisi
Judith
J
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. jcampisi@lbl.gov
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
D016159:Tumor Suppressor Protein p53