title: Alitretinoin: a comprehensive review.
abstract: BACKGROUND
  Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carried out to determine how best to utilize this characteristic in treatments for conditions such as chronic hand dermatitis.
  
  
  OBJECTIVE
  To review the literature on alitretinoin.
  
  
  METHODS
  The scope of the review encompasses ways that alitretinoin is currently and may potentially be utilized.
  
  
  CONCLUSIONS
  Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. Topical treatment with alitretinoin can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US.
authors.affiliation: Jefferson Medical College, USA.
authors.forename: Caleb
authors.initials: C
authors.lastname: Cheng
authors.forename: Jason
authors.initials: J
authors.lastname: Michaels
authors.forename: Noah
authors.initials: N
authors.lastname: Scheinfeld
mesh_terms: D000284:Administration, Oral; D000077556:Alitretinoin; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006229:Hand Dermatoses / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000378:metabolism; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D018168:Receptors, Retinoic Acid; D000077556:Alitretinoin; D014212:Tretinoin