[The activity of Willebrand factor--glycoproteins IIb/IIIa complex in patients with coronary and low extremity arterial atherothrombosis and type 2 diabetes mellitus].
A lot of attention has been paid lately to the study of risk factors of cardiovascular diseases in patients with diabetes mellitus type 2 (DM2). Numerous investigations have revealed a connection between the intensity of thrombus formation and carbohydrate exchange disturbances. In the present paper, the dependence of the levels of Willebrand factor--glycoproteins IIb/IIIa complex on the clinical forms of coronary artery disease (I-II functional class stenocardia; old myocardial infarction) and lower limb ischemic disease (intermittent claudication) in patients with DM2 were studied. The comparison group consisted of DM2 patients without clinical manifestations of coronary artery disease or lower limb ischemic disease; the control group consisted of practically healthy individuals. The study found that the level of Willebrand factor--glycoproteids IIb/IIIa complex was significantly higher in all DM2 patients vs. healthy controls.
Smirnova
I V
IV
Bokarev
I N
IN
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003328:Coronary Thrombosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*; D011379:Prognosis; D012720:Severity of Illness Index; D013053:Spectrophotometry; D018616:Ultrasonography, Doppler, Duplex; D014841:von Willebrand Factor / Q000378:metabolism*
D015415:Biomarkers; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014841:von Willebrand Factor