Efficacy of benzoxazinorifamycins in a mouse model of Chlamydia pneumoniae lung infection.
The efficacy of rifalazil and other benzoxazinorifamycins was tested in a mouse model of lung infection against Chlamydia pneumoniae. Rifalazil and six related new chemical entities all showed efficacy after one dose per day for 3 days at either 3 or 1 mg/kg of body weight.
Campbell
Lee Ann
LA
Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA.
Kuo
Cho-Chou
CC
Suchland
Robert J
RJ
Rothstein
David M
DM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002690:Chlamydia Infections / Q000188:drug therapy*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004195:Disease Models, Animal; D008168:Lung / Q000187:drug effects* / Q000382:microbiology; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D012294:Rifamycins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D012294:Rifamycins; C068980:KRM 1648