title: Liver resection for non-colorectal, non-neuroendocrine metastases: analysis of a multicenter study from Argentina.
abstract: OBJECTIVE
  Resection of colorectal liver metastases has become a standard of care, although the value of this procedure in non-colorectal non-neuroendocrine (NCRNNE) metastases remains controversial and is still a matter of debate. The aim of the study was to determine the utility of liver resection in the long-term outcome of patients with NCRNNE metastases.
  
  
  METHODS
  The records of 106 patients who underwent liver resection for NCRNNE metastases in the period 1989 to 2006 at 5 HPB Centers in Argentina were analyzed. Patient demographics, tumor characteristics, type of resection, long-term outcome and prognostic factors were analyzed. Depending on primary tumor sites, a comparative analysis of survival was performed.
  
  
  RESULTS
  Mean age was 54 (17-76). Hepatic metastases were solitary in 62.3% and unilateral in 85.6%. Primary tumor sites: Urogenital (37.7%), sarcomas (21.7%), breast (17.9%), gastrointestinal (6.6%), melanoma (5.7%), and others (10.4%). Fifty-one major hepatectomies and 55 minor resections were performed. Twenty patients underwent synchronous resections. An R0 resection could be achieved in 89.6%. Perioperative mortality was 1.8%. Overall, 1-year, 3-year, and 5-year survival rates were 67%, 34%, and 19%, respectively. Survival was significantly longer for metastases of urogenital (p=0.0001) and breast (p=0.003) origin. Curative resections (p=0.04) and metachronous disease (p=0.0001) were predictors of better survival.
  
  
  CONCLUSIONS
  Liver resection is an effective treatment for NCRNNE liver metastases; it gives satisfactory long-term survival especially in metachronous disease, in patients with metastases from urogenital and breast tumors and when R0 procedures can be performed.
authors.affiliation: Liver Transplantation Unit, Hospital Dr. Cosme Argerich, Buenos Aires, Argentina. jlendoire@yahoo.com.ar
authors.forename: J
authors.initials: J
authors.lastname: Lendoire
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authors.lastname: Moro
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authors.lastname: Andriani
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authors.lastname: Grondona
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authors.lastname: Gil
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authors.lastname: Raffin
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authors.lastname: Silva
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authors.lastname: Bracco
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authors.lastname: Podestá
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authors.lastname: Imventarza
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authors.lastname: Pekolj
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authors.initials: E
authors.lastname: De Santibañes