[Study of antituberculous activity of moxifloxacin conjugate with macrophage scavenger-receptor ligand].
Mycobacterium tuberculosis is an intracellular pathogen that persists in macrophages of the human host. An approach to improving the treatment of tuberculosis is target delivery of antibiotics to macrophages using ligands to macrophage receptors. The antituberculous activity of the conjugate of the antituberculous antibiotic moxifloxacin with carboxymethylglucan was studied in vitro using the J774 macrophage cell line and peritoneal macrophages. The antituberculous activity of the conjugate was higher than of the free moxifloxacin. The target antibiotic delivery to macrophage cells in tuberculosis infection was shown perspective.
Azaev
M Sh
MSh
Agafonov
A P
AP
Bodnev
S A
SA
Blinov
V M
VM
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000737:chemistry / Q000627:therapeutic use*; D002478:Cells, Cultured; D024841:Fluoroquinolones; D006801:Humans; D008024:Ligands; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D000077266:Moxifloxacin; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry / Q000627:therapeutic use*; D051116:Receptors, Scavenger / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D047071:beta-Glucans / Q000737:chemistry / Q000627:therapeutic use*
D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D008024:Ligands; D011804:Quinolines; D051116:Receptors, Scavenger; D047071:beta-Glucans; C029933:carboxymethyl-beta-1,3-glucan; D000077266:Moxifloxacin