title: [Primary synovial sarcoma of the kidney].
abstract: The authors present two cases of primary synovial sarcoma of the kidney. Both patients had a tumor mass in the kidney with vascular invasion of the inferior vena cava and right atrium of the heart in case no. 1. In case no. 2 retroperitoneal lymph node metastasis and multiple metastases to both lungs were observed. Radical nephrectomies were performed in both patients. Histologically, the tumor in case no. 1 was monophasic and in case no. 2 poorly differentiated. Immunohistochemically, vimentin was diffusely positive and a few tumor cells were positive for epithelial membrane antigen. The tumor cells were negative for keratins, S- 100 protein, CD 34, smooth muscle actin, and desmin. In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.
authors.affiliation: Ustav patologie 1, LF UK a VFN, Praha. jdrozenova@seznam.cz
authors.forename: J
authors.initials: J
authors.lastname: Drozenová
authors.forename: C
authors.initials: C
authors.lastname: Povýsil
authors.forename: D
authors.initials: D
authors.lastname: Tvrdík
authors.forename: M
authors.initials: M
authors.lastname: Babjuk
authors.forename: T
authors.initials: T
authors.lastname: Hanus
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013584:Sarcoma, Synovial / Q000737:chemistry / Q000473:pathology*