title: Fluid-particle dynamics in canalithiasis.
abstract: The semicircular canals (SCCs; located in the inner ear) are the primary sensors for angular motion. Angular head movements induce a fluid flow in the SCCs. This flow is detected by afferent hair cells inside the SCCs. Canalithiasis is a condition where small particles disturb this flow, which leads to benign paroxysmal positional vertigo (top-shelf vertigo). The present work investigates the interaction between the fluid flow and the particles on the basis of an idealized analytical model. Numerical solutions of the full model and a thorough analytical study of the linearized model reveal the principal mechanisms of canalithiasis. We propose a set of dimensionless numbers to characterize canalithiasis and derive explicit expressions connecting these dimensionless numbers directly to the typical clinical symptoms.
authors.affiliation: Institute of Fluid Dynamics, ETH Zurich, 8092 Zurich, Switzerland. obrist@ifd.mavt.ethz.ch
authors.forename: Dominik
authors.initials: D
authors.lastname: Obrist
authors.forename: Stefan
authors.initials: S
authors.lastname: Hegemann
mesh_terms: D003198:Computer Simulation; D006801:Humans; D007759:Labyrinth Diseases / Q000473:pathology*; D020347:Lithiasis / Q000473:pathology*; D008954:Models, Biological; D010316:Particle Size; D012665:Semicircular Canals / Q000033:anatomy & histology / Q000473:pathology*; D014717:Vertigo / Q000473:pathology