title: One hub-one process: a tool based view on regulatory network topology.
abstract: BACKGROUND
  The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks.
  
  
  RESULTS
  To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network only show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. These functional correlations decreases strongly when one consider proteins separated by more than two steps in the regulatory network. The network topology primarily reflects the processes that is orchestrated by each individual hub, whereas there is nearly no remnants of the history of protein duplications.
  
  
  CONCLUSIONS
  Our results suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.
authors.affiliation: Centro de Astrobiología, Instituto Nacional de Técnica Aeroespacial, Ctra de Ajalvir km 4, 28850 Torrejón de Ardoz, Madrid, Spain. bockaj@inta.es
authors.forename: Jacob Bock
authors.initials: JB
authors.lastname: Axelsen
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bernhardsson
authors.forename: Kim
authors.initials: K
authors.lastname: Sneppen
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D015966:Gene Expression Regulation, Fungal; D053263:Gene Regulatory Networks / Q000502:physiology; D005800:Genes, Fungal; D008957:Models, Genetic; D016571:Neural Networks, Computer; D021281:Quantitative Structure-Activity Relationship; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D049490:Systems Biology / Q000379:methods
chemical_list: D029701:Saccharomyces cerevisiae Proteins