title: Effect of ovarian hormones on serum adiponectin and resistin concentrations.
abstract: OBJECTIVE
  To investigate the effect of ovarian hormones on adiponectin and resistin levels in women.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirteen normally cycling women (7 in group 1 and 6 in group 2) and 8 postmenopausal women (group 3).
  
  
  METHODS
  Women of group 1 were investigated in a control cycle and in a subsequent cycle in which total abdominal hysterectomy plus bilateral salpingooophorectomy (TAH+BSO) was performed on day 3. In both cycles, the women received increasing doses of E(2) from days 3 to 5. Women of group 2 underwent TAH+BSO on day 3 without receiving any hormonal treatment. Women of group 3 received increasing doses of E(2) for 15 days.
  
  
  METHODS
  Adiponectin, resistin, and E(2) concentrations.
  
  
  RESULTS
  In group 1, serum adiponectin and resistin levels did not show any significant changes for the week following day 3 and were similar in the two cycles. In group 2, adiponectin and resistin levels were similar before and after TAH+BSO and remained stable during the first postoperative week. In group 3, no significant changes in adiponectin and resistin levels were seen during the 15 days of E(2) administration.
  
  
  CONCLUSIONS
  Adiponectin and resistin values were not affected either by estrogen treatment or after ovariectomy in women. It is suggested that ovarian hormones are not involved in the regulation of adiponectin and resistin secretion in women.
authors.affiliation: Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
authors.forename: Nektarios
authors.initials: N
authors.lastname: Chalvatzas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Dafopoulos
authors.forename: Georgios
authors.initials: G
authors.lastname: Kosmas
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kallitsaris
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
authors.forename: Ioannis E
authors.initials: IE
authors.lastname: Messinis
mesh_terms: D052242:Adiponectin / Q000097:blood; D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D008875:Middle Aged; D010052:Ovariectomy / Q000379:methods; D010053:Ovary / Q000378:metabolism; D017698:Postmenopause / Q000097:blood / Q000187:drug effects; D017697:Premenopause / Q000097:blood / Q000187:drug effects; D052243:Resistin / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D012739:Gonadal Steroid Hormones; C499624:RETN protein, human; D052243:Resistin; D004958:Estradiol