title: The diagnostic value of macrophage migration inhibitory factor (MIF) in gastric cancer.
abstract: The present study was conducted to investigate the sensitivity, specificity, predictive values and accuracy of serum MIF, CEA, CA 19-9 levels and their various combinations in patients with gastric cancer. Study group consists of pathologically verified, gastric cancer (n = 63) and apparently healthy controls (n = 50). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Serum values of patients were significantly higher than the controls (p = 0.011). Diagnostic sensitivity and specificity, predictive values and accuracies were calculated for each marker and their various combinations. The best results were achieved with the marker combination of MIF-CEA-CA 19-9 and MIF-CEA combination. In our opinion, the combination of the markers MIF-CEA is a valuable diagnostic tool for gastric cancer.
authors.affiliation: Preventive Oncology, Biostatistics and Epidemiology, Institute of Oncology, University of Istanbul, Capa, 34390 Istanbul, Turkey. hcamlica@istanbul.edu.tr
authors.forename: Hakan
authors.initials: H
authors.lastname: Camlica
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
authors.forename: Hilal
authors.initials: H
authors.lastname: Oguz
authors.forename: Ethem Nezih
authors.initials: EN
authors.lastname: Oral
authors.forename: Vildan
authors.initials: V
authors.lastname: Yasasever
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000097:blood*; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D008263:Macrophage Migration-Inhibitory Factors; D011956:Receptors, Cell Surface; C065686:carcinoembryonic antigen binding protein, human; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human