title: Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts.
abstract: To determine if administration of the anaesthetic cocktail, telazol-ketamine-xylazine (TKX) and pentothal (PEN) decreases serum concentrations of luteinizing hormone (LH) in pigs, the following experiment was performed. On day 1, eight gilts and six barrows of similar weight (75 kg) were anaesthetized with TKX (1 mL/22.5 kg body weight [BW] intramuscularly) and indwelling jugular catheters were inserted. On days 2, 6 and 8 blood samples were taken every 20 min, for 4 h before pigs were administered saline (day 2) or anaesthetized with TKX (day 6) and PEN (8.9 mg/kg BW intravenously, day 8). Blood samples were taken every 20 min for 4 h following administration of saline and anaesthetics. Mean serum concentrations of LH and cortisol did not differ (P > 0.05) within barrows or gilts from before administration of saline (day 2) to following saline administration. Mean serum concentrations of LH and cortisol were not different (P > 0.05) within barrows and gilts before administration of TKX (pre-TKX) or PEN compared with day 2 samples. Following administration of TKX (post-TKX), mean serum concentrations of LH decreased (P < 0.05) and remained decreased for 140 min, while mean serum concentrations of cortisol increased (P < 0.05) post-TKX and remained elevated for 140 min. In gilts, mean serum concentrations of LH did not differ (P > 0.05) from pre- to post-TKX. However, mean serum concentrations of cortisol increased (P < 0.05) post-TKX in gilts and remained elevated for 240 min. Following administration of PEN, mean serum concentrations of LH and cortisol within barrows and gilts were not different (P > 0.05) from concentrations before administration of PEN. Administration of TKX to barrows and gilts increased serum concentrations of cortisol, but transient decreases in serum concentrations of LH were observed only in barrows, indicating gonadal status and/or sex may influence the ability of TKX to alter circulating concentrations of LH in pigs.
authors.affiliation: Department of Animal and Range Sciences, South Dakota State University, Box 2170, Brookings, SD 57007, USA. jeffery_clapper@sdstate.edu
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Clapper
mesh_terms: D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011374:Progesterone / Q000097:blood; D012727:Sex Characteristics; D013552:Swine / Q000097:blood*; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology; D013992:Tiletamine / Q000008:administration & dosage / Q000494:pharmacology; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology; D015041:Zolazepam / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D014991:Xylazine; D013992:Tiletamine; D011374:Progesterone; D007649:Ketamine; D007986:Luteinizing Hormone; D015041:Zolazepam; D013874:Thiopental; D006854:Hydrocortisone