title: Host defense peptides and the new line of defence against multiresistant infections.
abstract: Increasing antibiotic resistance has led to an urgent need for new therapeutic approaches. Host defense peptides are known to be antimicrobial and have revealed broad immunomodulatory functions for both innate and adaptive immunity. This review will focus on the role of host defense peptides in infection and immune response and discuss its potential and limitations as a future therapeutical agent.
authors.affiliation: Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Hirsch
authors.forename: Frank
authors.initials: F
authors.lastname: Jacobsen
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Steinau
authors.forename: Lars
authors.initials: L
authors.lastname: Steinstraesser
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D007113:Immunity, Innate
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides