title: Catalytic asymmetric hydroxylation of oxindoles by molecular oxygen using a phase-transfer catalyst.
abstract: The highly enantioselective catalytic hydroxylation of 3-substituted oxindoles was achieved by using a phase-transfer catalyst with molecular oxygen as an oxidant. The product then was converted to an optically active compound 8, which was a synthetic precursor of alkaloid CPC-1.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagata
authors.forename: Takashi
authors.initials: T
authors.lastname: Itoh
mesh_terms: D002384:Catalysis; D006900:Hydroxylation; D007211:Indoles / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*
chemical_list: D007211:Indoles; D010100:Oxygen