title: [Tobacco contact dermatitis caused by sensitivity to sorbic acid].
abstract: BACKGROUND
  Contact dermatitis caused by tobacco is rare and poorly understood. In this paper, we report what is to our knowledge, the first case of tobacco contact dermatitis with identification of the causative agent.
  
  
  METHODS
  A 46-year-old man was hospitalised for diffuse dermatitis originating in the left leg. Subsequent epicutaneous tests indicated that this dermatitis was ascribable to sensitisation to the sorbic acid present in Fucidin cream applied around a chronic wound. A persistent plaque of eczema observed on the day of examination opposite the patient's right trouser pocket suggested the implication of tobacco powder with which the pocket was soiled. An epicutaneous test using tobacco (moistened in water) proved positive (++ at 48 and 72 h). This tobacco contained sorbic acid, used as a preservative.
  
  
  CONCLUSIONS
  The positive test for sorbic acid was relevant not only regarding the lesions on the patient's legs (application of a topical cream containing sorbic acid) but also for the lesion on the patient's thigh and for palmar dyshidrosis (through contact with strands of loose rolling tobacco). To our knowledge, this is the first recorded case of contact dermatitis caused by sorbic acid in tobacco.
authors.affiliation: Service de dermatologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France. agrange@chu-reims.fr
authors.forename: A
authors.initials: A
authors.lastname: Grange-Prunier
authors.forename: M
authors.initials: M
authors.lastname: Bezier
authors.forename: G
authors.initials: G
authors.lastname: Perceau
authors.forename: P
authors.initials: P
authors.lastname: Bernard
mesh_terms: D003877:Dermatitis, Contact / Q000209:etiology*; D005672:Fusidic Acid; D006801:Humans; D007868:Leg Dermatoses / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D013011:Sorbic Acid / Q000009:adverse effects*
chemical_list: D011310:Preservatives, Pharmaceutical; D005672:Fusidic Acid; D013011:Sorbic Acid