title: The development of drug metabolism research as expressed in the publications of ASPET: Part 2, 1959-1983.
abstract: In 25 years, drug metabolism research went from using subcellular particles of undefined content to an understanding of metabolism at the molecular level. The discoveries of cytochrome P450, enzyme induction, reactive intermediates, and genetic polymorphisms were milestones in the field. New publications from the American Society for Pharmacology and Experimental Therapeutics chronicled the discoveries and provided communications to advance the science of drug metabolism.
authors.affiliation: College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana, USA. pjmurphy12@aol.com
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Murphy
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000266:history*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System; D049673:History, 20th Century; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011642:Publications; D012958:Societies, Scientific
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System