title: Setting sun eye in normal healthy infants.
abstract: BACKGROUND
  The setting sun eye is a common sign associated with severe disorders signifying intracranial hypertension. Rarely it can be observed in a healthy infant. We conducted this study to evaluate and follow setting sun eye in normal infants without any obvious intracranial diseases.
  
  
  METHODS
  A cross-sectional study was conducted in the Children's Hospital Medical Center in Tehran from June 2001 to 2006. The study included 15 healthy infants who were referred to the neurosurgery clinic for setting sun eye. All were evaluated with brain imaging, and laboratory tests including at least thyroid function tests, and serum calcium and phosphorus. The cases were followed by regular outpatient visits until the age of 2 years.
  
  
  RESULTS
  They were 3-8 months old at the time of referring to the outpatient clinic. Setting sun eye was observed by the mother in all cases and confirmed during their visit to the clinic. All had normal brain imaging and normal laboratory tests (thyroid function and electrolytes). Setting sun eye disappeared gradually during the follow-up period with a range of 2-8 months after detection by the mother.
  
  
  CONCLUSIONS
  Despite the fact that setting sun eye is a grave sign, most commonly accompanied by other neurological signs and symptoms suggesting serious diseases, it might be observed as a sole finding in a totally normal infant with inconclusive brain imaging and laboratory tests. We found that this type of setting sun eye has a benign course and will disappear without any intervention several months after its detection (commonly before the age of 2 years without any intervention).
authors.affiliation: Department of Neurosurgery, Children's Hospital Medical Center, Medical Sciences, University of Tehran, Tehran, Iran. nejat@sina.tums.ac.ir
authors.forename: Farideh
authors.initials: F
authors.lastname: Nejat
authors.forename: Shahrooz
authors.initials: S
authors.lastname: Yazdani
authors.forename: Mostafa
authors.initials: M
authors.lastname: El Khashab
mesh_terms: D003430:Cross-Sectional Studies; D005123:Eye / Q000473:pathology*; D005128:Eye Diseases / Q000150:complications / Q000175:diagnosis; D005143:Eyelids / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000175:diagnosis; D007223:Infant; D019586:Intracranial Hypertension / Q000150:complications / Q000175:diagnosis; D008137:Longitudinal Studies; D008297:Male; D009460:Neurologic Examination / Q000379:methods