Outcome of anaemic monochorionic single survivors following early intrauterine rescue transfusion in cases of feto-fetal transfusion syndrome.
OBJECTIVE
To evaluate the outcome of severely anaemic monochorionic (MC) twins surviving the death of their co-twin following early intrauterine rescue transfusion in cases of feto-fetal transfusion syndrome (FFTS).


METHODS
We reviewed all MC pregnancies complicated with FFTS following primary management, in which a single intrauterine fetal death (IUFD) was diagnosed with certainty within 24 hours between January 1999 and December 2006. We included MC survivors who presented ultrasound or Doppler features of fetal anaemia following the death of their co-twin. Intrauterine transfusion (IUT) was given to all survivors who were anaemic.


RESULTS
Nineteen MC twin pregnancies presented a single intrauterine death (IUD) associated with an anaemic co-twin. Median gestational age at IUD was 23 [20-28] weeks. The median interval between IUD and IUT was 12 [8-24] hours. There were 58% (11/19) healthy survivors. Perinatal death rate was 26% (5/19) including 16% (3/19) intrauterine and 10% (2/19) neonatal deaths. Abnormal prenatal cerebral findings developed in 21% (4/19) cases, always within 1 month after the death of the co-twin. Considering occlusive techniques and other management separately, there were 64% (7/11) and 50% (4/8) healthy survivors, respectively, and perinatal death occurred in 36% (4/11) and 12.5% (1/8) of fetuses, respectively. Prenatal fetal cerebral lesions developed in 9% (1/11) of cases following occlusive techniques and in 37.5% (3/8) of fetuses when managed differently. The median gestational age at delivery in the survivors was 31 [25-38] weeks.


CONCLUSIONS
In cases of FFTS with single anaemic survivors, early IUT could be offered following extensive counselling and close follow up.
Quarello
E
E
Department of Obstetrics and Gynecology, Centre Hospitalier Intercommunal de Poissy, Poissy, France. e.quarello@orange.fr <e.quarello@orange.fr>
Stirnemann
J
J
Nassar
M
M
Nasr
B
B
Bernard
J-P
JP
Leleu-Huard
F
F
Ville
Y
Y
D001805:Blood Transfusion, Intrauterine / Q000379:methods* / Q000401:mortality; D001927:Brain Diseases / Q000196:embryology; D005260:Female; D005313:Fetal Death; D005330:Fetofetal Transfusion / Q000401:mortality / Q000628:therapy*; D005332:Fetoscopy; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D017741:Survivors; D014310:Triplets; D014427:Twins