Low oxygen stimulates the immune system.
Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.
Maltzman
J S
JS
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. maltz@mail.med.upenn.edu
Haase
V H
VH
D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D007107:Immune System / Q000502:physiology*; D007674:Kidney Diseases / Q000209:etiology; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D051793:Hypoxia-Inducible Factor 1; D000099162:Endothelial PAS Domain-Containing Protein 1