Baseless assumptions: activation of TLR9 by DNA.
The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent manner.
Gangloff
Monique
M
Department of Biochemistry, Cambridge University, 80 Tennis Road, Cambridge CB2 1GA, UK. mg308@mole.bio.cam.ac.uk
Gay
Nicholas J
NJ
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry / Q000276:immunology; D046709:Pattern Recognition, Physiological; D051217:Toll-Like Receptor 9 / Q000276:immunology* / Q000378:metabolism
D009841:Oligonucleotides; D051217:Toll-Like Receptor 9; D004247:DNA