Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury.
BACKGROUND
The list of clinically relevant molecules that affect skeletal and cardiac muscle mitochondria is gradually increasing, which strongly suggest that mitochondrial toxicity should be an important end point during the design and testing of novel pharmaceuticals.


OBJECTIVE
The present review intends to describe mechanisms by which clinically relevant drugs are known to alter mitochondrial function in cardiac and skeletal muscle, which is suggested to be involved in the toxicity associated with those drugs.


METHODS
Literature databases were searched in order to identify clinically relevant drugs with associated mitochondrial muscle toxicity.


CONCLUSIONS
Mitochondrial function is important in the context of muscle survival, hence, the requirement to identify novel mitochondrial targets and develop new therapies to counteract chemical-induced degeneration of mitochondrial function and muscle performance.
Sardão
Vilma A
VA
University of Coimbra, Center for Neurosciences and Cell Biology, Department of Zoology, 3004-517 Coimbra, Portugal.
Pereira
Sandro L
SL
Oliveira
Paulo J
PJ
D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure