Practical aspects of hydrophobic polycationic bactericidal "paints".
We previously discovered that coating solid surfaces with long-chained linear N-dodecyl,N-methyl-polyethylenimine makes them bactericidal and virucidal. In the present study, focusing on the use of this microbicidal paint to kill airborne Escherichia coli and Staphylococcus aureus, we have systematically investigated the dependence of this effect on the concentration and mode of application of the hydrophobic polycation, the number of coats, the nature of the solvent, and the presence of a dye in such paint. In addition, the latter's ability to be regenerated after use, stability upon repeated washings, and mammalian toxicity has been evaluated.
Mukherjee
Koushik
K
Departments of Chemistry and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Rivera
Jaime J
JJ
Klibanov
Alexander M
AM
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D002412:Cations; D002470:Cell Survival / Q000187:drug effects; D003666:Decontamination / Q000379:methods; D004926:Escherichia coli / Q000166:cytology* / Q000187:drug effects*; D057927:Hydrophobic and Hydrophilic Interactions; D010150:Paint / Q000382:microbiology*; D011094:Polyethyleneimine / Q000008:administration & dosage* / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000166:cytology* / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002412:Cations; D011094:Polyethyleneimine