title: Cerebral perfusion and oxygenation differences in Alzheimer's disease risk.
abstract: Functional MRI has demonstrated differences in response to memory performance based on risk for Alzheimer's disease (AD). The current study compared blood oxygen level dependent (BOLD) functional MRI response with arterial spin labeling (ASL) perfusion response during an associative encoding task and resting perfusion signal in different risk groups for AD. Thirteen individuals with a positive family history of AD and at least one copy of the apolipoprotien E epsilon4 (APOE4) gene (high risk) were compared to ten individuals without these risk factors (low risk). In the medial temporal lobes (MTLs) the high risk group had an elevated level of resting perfusion, and demonstrated decreased fractional BOLD and perfusion responses to the encoding task. However, there was no difference in the absolute cerebral blood flow during the task. These data demonstrate that individuals with increased risk for Alzheimer's disease have elevated MTL resting cerebral blood flow, which significantly influences apparent differences in BOLD activations. BOLD activations should be interpreted with caution, and do not necessarily reflect differences in neuronal activation.
authors.affiliation: University of California at San Diego, Department of Neuroscience, La Jolla, CA 92037-0949, United States. afleisher@ucsd.edu
authors.forename: Adam S
authors.initials: AS
authors.lastname: Fleisher
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Podraza
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Bangen
authors.forename: Curtis
authors.initials: C
authors.lastname: Taylor
authors.forename: Ayesha
authors.initials: A
authors.lastname: Sherzai
authors.forename: Kunal
authors.initials: K
authors.lastname: Sidhar
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Liu
authors.forename: Anders M
authors.initials: AM
authors.lastname: Dale
authors.forename: Richard B
authors.initials: RB
authors.lastname: Buxton
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D053327:Apolipoprotein E4 / Q000235:genetics; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005192:Family Health; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood*; D012306:Risk; D013702:Temporal Lobe / Q000098:blood supply*; D013997:Time Factors
chemical_list: D053327:Apolipoprotein E4; D010100:Oxygen