Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma.
OBJECTIVE
Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma


METHODS
The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups.


RESULTS
A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective.


CONCLUSIONS
The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline.
Rismanchian
Akram
A
Department of Ophthalmology, Isfahan University of Medical Science, Feiz Hospital, Isfahan, Iran.
Eslami
Fateme
F
Moeini
Heidarali
H
Attarzade
Hosein
H
Naderibeni
Afsane
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D013449:Sulfonamides; D013876:Thiophenes; D000077338:Latanoprost; D013999:Timolol; C062765:dorzolamide