title: Effect of porin loss on the activity of tigecycline against Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC-type beta-lactamases.
abstract: Tigecycline showed excellent in vitro activity against 50 clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases, plasmid-mediated AmpC-type beta-lactamases, or both. This activity was not affected by porin loss. Porin loss, however, did affect the activity of imipenem against strains that expressed both types of enzymes.
authors.affiliation: Department of Microbiology, School of Medicine, Seville 41009, Spain. conejo@us.es
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Conejo
authors.forename: J Ramón
authors.initials: JR
authors.lastname: Hernández
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pascual
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D010957:Plasmids; D018272:Porins / Q000235:genetics / Q000502:physiology*; D000078304:Tigecycline; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D018272:Porins; D000078304:Tigecycline; D015378:Imipenem; D001618:beta-Lactamases; D008911:Minocycline