title: Anti-microfilarial activity of methanolic extract of Vitex negundo and Aegle marmelos and their phytochemical analysis.
abstract: In the present study, methanolic extracts of roots of Vitex negundo L. and extracts of leaves of Vitex negundo L., Ricinus communis L. and Aegle marmelos Corr. were explored for possible antifilarial effect against Brugia malayi microfilariae. It was observed that among the herbal extracts, root extract of Vitex negundo L. and leaves extract of Aegle marmelos Corr. at 100 ng/ml concentration showed complete loss of motility of microfilariae after 48 hr of incubation. Thin layer chromatography of the extracts revealed the presence of alkaloids, saponin and flavonoids in the roots of Vitex negundo L. and coumarin in the leaves of Aegle marmelos Corr.
authors.affiliation: P G Department of Microbiology & Rajiv Gandhi Biotechnology Centre, RTM, Nagpur University, Nagpur 440 033, India.
authors.forename: K N
authors.initials: KN
authors.lastname: Sahare
authors.forename: V
authors.initials: V
authors.lastname: Anandhraman
authors.forename: V G
authors.initials: VG
authors.lastname: Meshram
authors.forename: S U
authors.initials: SU
authors.lastname: Meshram
authors.forename: M V R
authors.initials: MV
authors.lastname: Reddy
authors.forename: P M
authors.initials: PM
authors.lastname: Tumane
authors.forename: K
authors.initials: K
authors.lastname: Goswami
mesh_terms: D045471:Aegle; D000818:Animals; D017178:Brugia malayi / Q000187:drug effects*; D004605:Elephantiasis, Filarial / Q000188:drug therapy; D005369:Filaricides / Q000494:pharmacology*; D006801:Humans; D008515:Medicine, Ayurvedic; D008842:Microfilariae / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012278:Ricinus; D020950:Vitex
chemical_list: D005369:Filaricides; D010936:Plant Extracts