title: Classification of mass-spectrometric data in clinical proteomics using learning vector quantization methods.
abstract: In the present contribution we propose two recently developed classification algorithms for the analysis of mass-spectrometric data-the supervised neural gas and the fuzzy-labeled self-organizing map. The algorithms are inherently regularizing, which is recommended, for these spectral data because of its high dimensionality and the sparseness for specific problems. The algorithms are both prototype-based such that the principle of characteristic representants is realized. This leads to an easy interpretation of the generated classifcation model. Further, the fuzzy-labeled self-organizing map is able to process uncertainty in data, and classification results can be obtained as fuzzy decisions. Moreover, this fuzzy classification together with the property of topographic mapping offers the possibility of class similarity detection, which can be used for class visualization. We demonstrate the power of both methods for two exemplary examples: the classification of bacteria (listeria types) and neoplastic and non-neoplastic cell populations in breast cancer tissue sections.
authors.affiliation: Medical Department, University Leipzig Germany. thomas.villmann@medizin.uni-leipzig.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Villmann
authors.forename: Frank-Michael
authors.initials: FM
authors.lastname: Schleif
authors.forename: Markus
authors.initials: M
authors.lastname: Kostrzewa
authors.forename: Axel
authors.initials: A
authors.lastname: Walch
authors.forename: Barbara
authors.initials: B
authors.lastname: Hammer
mesh_terms: D000465:Algorithms; D001419:Bacteria / Q000145:classification; D001940:Breast; D003205:Computing Methodologies; D003627:Data Interpretation, Statistical; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D008433:Mathematics; D015233:Models, Statistical; D009369:Neoplasms / Q000473:pathology; D040901:Proteomics / Q000295:instrumentation / Q000379:methods