title: Evaluation of two anti-hepatitis E virus IgM kits.
abstract: OBJECTIVE
  To evaluate two commercial anti-hepatitis E virus (HEV) IgM kits used for differential diagnosis of acute enteric viral hepatitis.
  
  
  METHODS
  The kit for IgM capture assay, was produced with a recombinant HEV structural protein protecting primates against experimental infection by different HEV genotypes, while the other kit for indirect ELISA was produced with recombinant structural proteins from different HEV genotypes. The serum specimens were taken from 241 cases with a confirmed or presumptive diagnosis of hepatitis A and 74 cases with a confirmed or presumptive diagnosis of hepatitis E.
  
  
  RESULTS
  The sensitivity and specificity of the IgM capture assay kit were 97% and 100%, respectively, and the corresponding values for the other kit were 70% and 78%, respectively.
  
  
  CONCLUSIONS
  The IgM capture assay kit has higher sensitivity and specificity in diagnosing acute enteric viral hepatitis E.
authors.affiliation: National Institute of Diagnostics and Vaccine Development for Infectious Diseases, Xiamen University, Xiamen 361005, Fujian, China.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Ge
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zheng
authors.forename: Qing-Shun
authors.initials: QS
authors.lastname: Guo
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Jiang
authors.forename: Mun-Hon
authors.initials: MH
authors.lastname: Ng
authors.forename: Ning-Shao
authors.initials: NS
authors.lastname: Xia
mesh_terms: D003937:Diagnosis, Differential; D016751:Hepatitis E / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
chemical_list: D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic