Viscoelastic characteristics of in vitro vital and devitalized rat aorta and human arterial prostheses.
The arterial wall viscoelasticity plays an essential role in the vascular responsiveness to vasoactive drugs or pathologies. The aim of this investigation was to derive and compare resonance curve (RC), natural frequency (f(0)), dynamic modulus of elasticity (E'), and coefficient of viscosity (beta) of (i) vital and devitalized preparations of rat thoracic and abdominal aorta, (ii) human arterial prostheses, and to study the histomorphology of vital and devitalized rat aorta. The method of low frequency forced oscillations was employed. RC of vital preparations showed a hardening type of elasticity whereas in devitalized preparations it was of softening type. E' increased nonlinearly, f(0) decreased and beta increased linearly with equivalent intraluminal pressure (p(eqi)). Distensibility of abdominal aorta was lower than thoracic aorta. Distensibility decreased with increasing p(eqi). E', f(0), and beta increased significantly after devitalization. It was suggested that postmortem viscoelastic characteristics should not be used directly to specify the vital arteries viscoelasticity. RC of human prostheses showed a softening type of elasticity. Arterial prostheses have low circumferential distensibility with E'-values higher than reported in the literature for human arteries. The method of forced oscillations could be employed for studying the arterial wall biomechanics and viscoelasticity of arterial prostheses.
Antonova
Mariya L
ML
Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 23, 1113 Sofia, Bulgaria. antonova@bio.bas.bg
Antonov
Pavel S
PS
Marinov
Georgi R
GR
Vlaskovska
Mila V
MV
Kasakov
Lubomir N
LN
D000818:Animals; D001011:Aorta / Q000502:physiology* / Q000637:transplantation; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D002474:Cell-Free System; D003198:Computer Simulation; D017076:Computer-Aided Design; D004548:Elasticity; D019544:Equipment Failure Analysis; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D051381:Rats; D017208:Rats, Wistar; D014783:Viscosity