title: [Calcium antagonists in the preoperative preparation of pregnant women with gestosis].
abstract: Differential preoperative preparation of pregnant women with gestosis, which is aimed at eliminating dysfunction of the universal secondary calcium messenger and preventing further disorders caused by calcium antagonists, is accompanied by positive changes in the basic links of development of the general adaptation syndrome--the autonomic nervous and cardiovascular systems. A physiologically required reduction in total peripheral vascular resistance (TPVE) is achieved in pregnant women with hyper- and eukinetic hemodynamics. In pregnant women with hypokinetic type, who receive hydroxyethyl starch-130/04 solution in the infusion therapy protocol, there is elimination of its pathological increase and there is a tendency for its physiological reduction. Obviating the discrepancy between cardiac index and TPVE causes a change of the hyper- and hypokinetic hemodynamic types to the eukinetic one, which is attended by development of physiological sympathicotonia and by almost complete normalization of water metabolic parameters in pregnant women with gestosis.
authors.forename: N L
authors.initials: NL
authors.lastname: Shepetovskaia
authors.forename: G M
authors.initials: GM
authors.lastname: Piovarova
authors.forename: V A
authors.initials: VA
authors.lastname: Gur'ianov
authors.forename: G N
authors.initials: GN
authors.lastname: Tolmachev
authors.forename: A V
authors.initials: AV
authors.lastname: Volodin
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011300:Preoperative Care / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers