[Study on preparation of phenols gastric floating tablet].
OBJECTIVE
To study the preparation of phenols gastric floating tablet.


METHODS
The tablets which were prepared using Eudragit IV, HPMC(K4M), MCC101 and Octadecanol as excipients were evaluated by vitro floatation and releasing performance. The pressure of preparationg was also study to select the optimal preparation.


RESULTS
The tablets were successfully prepared in which the drug, Eudragit IV, Octadecanol were 31% respectively,and MCC101 was 7%. And 3-4 kg was found to be the eligible pressure.


CONCLUSIONS
The study was found to be effective in the process of phenols gastric floating tablet.
Zhai
Xiao-Ling
XL
Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
Ni
Jian
J
Gu
Yu-Long
YL
D004337:Drug Carriers; D005079:Excipients / Q000737:chemistry; D005765:Gastrointestinal Agents / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D004337:Drug Carriers; D005079:Excipients; D005765:Gastrointestinal Agents; D010636:Phenols; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer