Glycosides from the root of Iodes cirrhosa.
Seven new neolignan glycosides ( 1- 7), two arylglycerol glycosides ( 8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of Iodes cirrhosa. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Based on analysis of the NMR data of threo and erythro 8-4'-oxyneolignans and arylglycerols in different solvents, the validity of J 7,8 and Deltadelta C8-C7 values to distinguish threo and erythro derivatives was discussed. In the in vitro assays, compound 4 and liriodendrin ( 17) both showed activity against glutamate-induced PC12 cell damage at 10 (-5) M.
Gan
Maoluo
M
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
Zhang
Yanling
Y
Lin
Sheng
S
Liu
Mingtao
M
Song
Weixia
W
Zi
Jiachen
J
Yang
Yongchun
Y
Fan
Xiaona
X
Shi
Jiangong
J
Hu
Jinfeng
J
Sun
Jiandong
J
Chen
Naihong
N
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D016716:PC12 Cells / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans; D018698:Glutamic Acid