title: The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders.
abstract: The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. In daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. In this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.
authors.affiliation: Erasmus University Medical Center, Department of Gastroenterology and Hepatology, Postbus 2040, 3000 CA Rotterdam, The Netherlands. e.vansoest@erasmusmc.nl
authors.forename: Eva M
authors.initials: EM
authors.lastname: van Soest
authors.forename: Jeanne P
authors.initials: JP
authors.lastname: Dieleman
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D001471:Barrett Esophagus / Q000473:pathology; D018680:Cholinergic Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000473:pathology; D004947:Esophagus / Q000187:drug effects* / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D012307:Risk Factors
chemical_list: D018680:Cholinergic Antagonists