title: Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease.
abstract: OBJECTIVE
  To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD).
  
  
  METHODS
  We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method.
  
  
  RESULTS
  Statistical maps demonstrated a more extensive and severe reduction in perfusion in the unaware group than in the aware group. Quantitative analysis demonstrated a significant difference between the groups in the right subcallosal, anterior cingulate and cingulate gyri and left orbital, subcallosal, and anterior cingulate gyri.
  
  
  CONCLUSIONS
  Functional damage to the inferior, medial and orbital frontal lobes as well as the anterior cingulate gyri may be associated with the lack of awareness in patients with early AD.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan. h-hanyu@tokyo-med.ac.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Hanyu
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sato
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Akai
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shimizu
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hirao
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kanetaka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Koizumi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D001364:Awareness / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging* / Q000473:pathology*; D010465:Perception / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon