title: On stent-graft models in thoracic aortic endovascular repair: a computational investigation of the hemodynamic factors.
abstract: In treating thoracic aortic diseases, endovascular repair involves the placement of a self-expanding stent-graft system across the diseased thoracic aorta. Computational fluid dynamic techniques are applied to model the blood flow by numerically solving the three-dimensional continuity equation and the time-dependent Navier-Stokes equations for an incompressible fluid. From our results, high blood pressure level and high systolic slope of the pressure waveform will significantly increase the drag force on a stent-graft whereas high blood viscosity causes only a mild increase. It indicates that hemodynamic factors might have an important impact on the drag force and thus play a significant role in the risk of stent-graft failure.
authors.affiliation: Department of Electrical and Electronic Engineering, University of Hong Kong, Pokfulam Road, Hong Kong. skfung@eee.hku.hk
authors.forename: George S K
authors.initials: GS
authors.lastname: Fung
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
authors.forename: Stephen W K
authors.initials: SW
authors.lastname: Cheng
authors.forename: K W
authors.initials: KW
authors.lastname: Chow
mesh_terms: D017130:Angioplasty / Q000295:instrumentation*; D001013:Aorta, Thoracic / Q000503:physiopathology / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000503:physiopathology / Q000601:surgery*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D019917:Blood Vessel Prosthesis Implantation; D001809:Blood Viscosity / Q000502:physiology; D003198:Computer Simulation; D019544:Equipment Failure Analysis; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008432:Mathematical Computing; D033081:Shear Strength; D015607:Stents