Isolated myelosarcoma development in an adolescent chronic myeloid leukemia patient with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36).
Additional chromosomal abnormalities are found in 5-20% of patients during chronic phase of chronic myeloid leukemia and in 60-80% preceding or accompanying blast crisis. These abnormalities are important in disease progression and, because they may occur before hematological and clinical symptoms, can be taken as a prognostic indicator. An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in bone marrow examinations and then developed isolated myelosarcoma 1 year after onset, with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36).
Oren
Hale
H
Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, 35340 Balçova, Izmir, Turkey. hale.oren@deu.edu.tr
Yilmaz
Sebnem
S
Sercan
Zeynep
Z
Demircioğlu
Fatih
F
Yüksel
Erdinç
E
Irken
Gülersu
G
D000293:Adolescent; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000235:genetics*; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D023981:Sarcoma, Myeloid / Q000150:complications*; D014178:Translocation, Genetic