NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis.
NKT cells are true Ag-specific T cells that also have innate properties and form a bridge between the innate and adaptive immune systems. Distinct NKT cell subsets play positive and negative regulatory roles and define a new immunoregulatory axis with broad implications for tumor immunity and other immunological and disease settings.
Berzofsky
Jay A
JA
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1578, USA. berzofsk@helix.nih.gov
Terabe
Masaki
M
D000818:Animals; D002450:Cell Communication / Q000235:genetics / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007694:Killer Cells, Natural / Q000145:classification* / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000145:classification* / Q000276:immunology* / Q000378:metabolism
D018984:Epitopes, T-Lymphocyte