A novel cholic acid-based contrast enhancement agent for targeted MRI.
The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.
Chong
Hyun-Soon
HS
Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, 3101 S. Dearborn St., LS 182, Chicago, IL 60616, USA. chong@iit.edu
Song
Hyun A
HA
Lim
Sooyoun
S
Macrenaris
Keith
K
Ma
Xiang
X
Lee
Haisung
H
Bui
Phuong
P
Meade
Thomas
T
D002614:Chelating Agents / Q000138:chemical synthesis*; D019826:Cholic Acid / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods*; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000379:methods*; D046529:Microscopy, Electron, Transmission / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D012680:Sensitivity and Specificity
D002614:Chelating Agents; D003287:Contrast Media; D008024:Ligands; D009942:Organometallic Compounds; D005682:Gadolinium; D019826:Cholic Acid