title: A multicentre controlled study of the InLine radiofrequency ablation device for liver transection.
abstract: BACKGROUND
  Surgical resection is the most effective therapy for liver cancer. Intraoperative blood loss during liver resection remains a major concern due to association with higher postoperative complications. The InLine radiofrequency ablation device (ILRFA) has achieved promising results in liver surgery with minimal blood loss and no increase of postoperative complications. In this multicentre controlled study, 108 patients undergoing liver resection were investigated.
  
  
  METHODS
  A total of 108 patients underwent liver resections in 4 medical centres; the prospective sequential cohort study consisted of 54 ILRFA and 54 ultrasonic surgical aspirator transections as the control group.
  
  
  RESULTS
  The type of liver resection performed was very similar in both groups. The median number of RFA deployments was 3 (range 1-12) with a median coagulation time of 9 (range 3-36) min. Median blood loss was 165+/-20 ml (range 5-675) in the ILRFA and 654+/-83 ml (range 80-3600) in the control group (p<0.001). The median transection time was 27 (2-219) min in the ILRFA group and 35 (5-62) min in controls.
  
  
  CONCLUSIONS
  Our study indicates that ILRFA device for liver transection is effective in reducing blood loss and is safe. Precoagulation before parenchymal transection appears to be a valid concept in liver surgery. The avoidance of vascular inflow occlusion during parenchymal transection could also be of value.
authors.affiliation: University of New South Wales, Department of Surgery, St George Hospital, Sydney, Australia.
authors.forename: Peng
authors.initials: P
authors.lastname: Yao
authors.forename: Frank
authors.initials: F
authors.lastname: Chu
authors.forename: Steve
authors.initials: S
authors.lastname: Daniel
authors.forename: Aravin
authors.initials: A
authors.lastname: Gunasegaram
authors.forename: Tristan
authors.initials: T
authors.lastname: Yan
authors.forename: Werner
authors.initials: W
authors.lastname: Lindemann
authors.forename: Georg
authors.initials: G
authors.lastname: Pistorius
authors.forename: Martin
authors.initials: M
authors.lastname: Schilling
authors.forename: Junji
authors.initials: J
authors.lastname: Machi
authors.forename: Randall
authors.initials: R
authors.lastname: Zuckerman
authors.forename: David L
authors.initials: DL
authors.lastname: Morris