[Preparation of alpha-hydrocycholic-beta-cyclodextrin inclusion compound].
OBJECTIVE
To study the preparation of alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound.


METHODS
It was studied with orthogonal design to analysis three factors of inclusion rate such as the weight ratio between HDCA and beta-Cyclodextrin, the temperature and the reaction time. Fourier transform infrared spectroscopy, scanning electron microscopy, taste and solubility test were used to identify the inclusion compound.


RESULTS
Stable inclusion compound was made by HDCA and beta-Cyclodextrin. The weight ratio between HDCA and beta-Cyclodextrin was the most important factor. The alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound taste and the solubility were improved.


CONCLUSIONS
The optimum preparation condition is alpha-Hydrocycholic : beta-Cyclodextrin = 8.67 : 1, the inclusion temperature is 60 degrees C and the inclusion time is 30 minutes.
Bian
Yan-hong
YH
Department of Pharmacy, Huai'an Second Hospital, Huai'an 223002, China. zqh67@163.com
Zhang
Dan-yan
DY
Xiong
Qing-ping
QP
D000704:Analysis of Variance; D003840:Deoxycholic Acid / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D047392:beta-Cyclodextrins; D003840:Deoxycholic Acid