title: Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging.
abstract: OBJECTIVE
  We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI.
  
  
  METHODS
  A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale.
  
  
  RESULTS
  Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85-1.84, chi(2) = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI.
  
  
  CONCLUSIONS
  In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.
authors.affiliation: Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy. geriat.dot@geriatria.uniba.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.forename: Alessia
authors.initials: A
authors.lastname: D'Introno
authors.forename: Anna M
authors.initials: AM
authors.lastname: Colacicco
authors.forename: Cristiano
authors.initials: C
authors.lastname: Capurso
authors.forename: Angelo
authors.initials: A
authors.lastname: Del Parigi
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
authors.forename: Orlando
authors.initials: O
authors.lastname: Todarello
authors.forename: Vincenza
authors.initials: V
authors.lastname: Pellicani
authors.forename: Andrea
authors.initials: A
authors.lastname: Santamato
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Scapicchio
authors.forename: Stefania
authors.initials: S
authors.lastname: Maggi
authors.forename: Emanuele
authors.initials: E
authors.lastname: Scafato
authors.forename: Claudia
authors.initials: C
authors.lastname: Gandin
authors.forename: Antonio
authors.initials: A
authors.lastname: Capurso
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003072:Cognition Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology*; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution