title: Cigarette smoking, systolic blood pressure, and cardiovascular diseases in the Asia-Pacific region.
abstract: OBJECTIVE
  Smoking and increased levels of blood pressure (BP) substantially increase the risk of cardiovascular diseases (CVD). If these 2 risk factors have a synergistic impact on cardiovascular events, lowering BP and quitting smoking will contribute more to reducing CVD than would be expected from ignoring their interaction.
  
  
  METHODS
  Individual participant data were combined from 41 cohorts, involving 563 144 participants (82% Asian). During a median of 6.8 years follow-up, 4344 coronary heart disease (CHD) and 5906 stroke events were recorded. Repeat measures of systolic blood pressure (SBP) were used to adjust for regression dilution bias. Hazard ratios (HRs) and 95% confidence intervals (CIs) for SBP by cigarette smoking status were estimated from Cox proportional hazard models adjusted for age and stratified by study and sex.
  
  
  RESULTS
  Data suggested a log-linear relationship between SBP and all subtypes of CVD. The HRs relating SBP to both CHD and ischemic stroke were broadly similar irrespective of smoking status (P>/=0.1). For hemorrhagic stroke (intracerebral hemorrhage), the HRs (95% CIs) for an additional 10 mm Hg increment in SBP were 1.81 (1.73 to 1.90) for present smokers and 1.66 (1.59 to 1.73) for nonsmokers (P=0.003). For every subtype of cardiovascular events, similar results were found for analyses involving only fatal events.
  
  
  CONCLUSIONS
  Smoking exacerbated the impact of SBP on the risk of hemorrhagic stroke. Although quitting smoking and lowering BP are both crucial for prevention of CVD, combining the 2 could be expected to have extra beneficial effect on preventing hemorrhagic stroke.
authors.affiliation: Nutrition and Lifestyle Division, The George Institute for International Health, PO Box M201, Missenden Road, Camperdown, NSW 2050, Australia. knakamura@george.org.au
authors.forename: Koshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Federica
authors.initials: F
authors.lastname: Barzi
authors.forename: Tai-Hing
authors.initials: TH
authors.lastname: Lam
authors.forename: Rachel
authors.initials: R
authors.lastname: Huxley
authors.forename: Valery L
authors.initials: VL
authors.lastname: Feigin
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.forename: Jean
authors.initials: J
authors.lastname: Woo
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Carlene M M
authors.initials: CM
authors.lastname: Lawes
authors.forename: Il
authors.initials: I
authors.lastname: Suh
authors.forename: Mark
authors.initials: M
authors.lastname: Woodward
mesh_terms: D000328:Adult; D001210:Asia, Southeastern / Q000453:epidemiology; D044466:Asian People / Q000706:statistics & numerical data; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002545:Brain Ischemia / Q000453:epidemiology / Q000208:ethnology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000208:ethnology; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000208:ethnology; D015331:Cohort Studies; D015897:Comorbidity / Q000639:trends; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D010139:Pacific Islands / Q000453:epidemiology; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012907:Smoking / Q000453:epidemiology* / Q000208:ethnology; D016540:Smoking Cessation