title: [Study on preparation of ampelopsin liposomes].
abstract: OBJECTIVE
  To study the formulation and preparation of ampelopsin liposomes and evaluate their quality.
  
  
  METHODS
  The liposomes were prepared by a film-ultrasonic dispersion technique. Served as quota with the entrapment ratio and appearance and diameter of the liposomes, the optimal formulation and preparation were selected by means of an uniform design test. The appearance of liposomes was observed by micrography. The diameter and electric charge of surface were determined by granularity mensuration instrument. The entrapment ratio and the leakage rate of ampelopsin liposome were determined by means of dialyze. The content of ampelopsin was determined by UV.
  
  
  RESULTS
  The result of electron micrography and the size distribution showed that the liposomes were similar to spherical small unilamellar vesicles. The mean diameter was (258.2 +/- 51.2) nm and the electric charge of surface is 19.0 mV. The entrapment ratio of ampelopsin liposomes was 62. 3% and the lecithoid oxidative rate was 0.83% (n = 3).
  
  
  CONCLUSIONS
  The selected formulation and preparation of ampelopsin liposomes is efficient and practicable.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510089, China.
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: He
authors.forename: De-Yu
authors.initials: DY
authors.lastname: Liu
authors.forename: Sa
authors.initials: S
authors.lastname: Zeng
authors.forename: Jian-Tao
authors.initials: JT
authors.lastname: Ye
mesh_terms: D005419:Flavonoids / Q000737:chemistry*; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry*; D008854:Microscopy, Electron
chemical_list: D005419:Flavonoids; D008081:Liposomes; C106407:ampelopsin