[Antiedematous effect of diphenyliodinium salts on experimental toxic lung edema].
A series of diphenyliodinium (DPI) salts (chloride, sulfate, acetate and iodide) were synthesized and studied as preventive and therapeutic agents in the model toxic lung edema induced by thiourea and phosgene in rats. All DPI salts exhibited high antiedematous activity. The preventive action of drugs was more effective than their curative effect. The duration of the antiedematous action of DPI iodide exceeded 24 h. The effective dose of DPI salts in the toxic lung edema was within 0.2-0.5 LD50.
Torkunov
P A
PA
Zemlianoĭ
A V
AV
Shabanov
P D
PD
D000818:Animals; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000633:toxicity; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D009249:NADP / Q000037:antagonists & inhibitors*; D009861:Onium Compounds / Q000627:therapeutic use*; D010705:Phosgene / Q000633:toxicity; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats
D001713:Biphenyl Compounds; D002619:Chemical Warfare Agents; D004791:Enzyme Inhibitors; D009861:Onium Compounds; C031291:diphenyliodonium; D010705:Phosgene; D009249:NADP