Molecular diagnostic and surveillance tools for global malaria control.
Malaria is the most devastating parasitic infection in the world, annually causing over 1 million deaths and extensive morbidity. The global burden of malaria has increased over the last several decades, as have rates of imported malaria into non-endemic regions. Rapid and accurate diagnostics are a crucial component of malaria control strategies, and epidemiological surveillance is required to monitor trends in malaria prevalence and antimalarial drug resistance. Conventional malaria diagnostic and surveillance tools can be cumbersome and slow with limitations in both sensitivity and specificity. New molecular techniques have been developed in an attempt to overcome these restrictions. These molecular techniques are discussed with regard to their technical advantages and disadvantages, with an emphasis on the practicality of implementation in malaria-endemic and non-endemic regions.
Erdman
Laura K
LK
McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, MaRS Centre, 101 College Street, Suite 10-401, Toronto, Ontario, Canada M5G1L7.
Kain
Kevin C
KC
D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000175:diagnosis* / Q000517:prevention & control*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D012680:Sensitivity and Specificity; D018571:Sentinel Surveillance; D014195:Travel
D000962:Antimalarials