Mutations in influenza A virus (H5N1) and possible limited spread, Turkey, 2006.
We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey. Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.
Altiok
Ender
E
Acibadem Genetic Diagnosis Center, Istanbul, Turkey. ealtiok@asg.com.tr
Taylan
Fulya
F
Yenen
Osman S
OS
Demirkeser
Gülşah
G
Bozaci
Mürvet
M
Onel
Derya
D
Akcadag
Birsen
B
Iyisan
A Selma
AS
Ciblak
Meral
M
Bozkaya
Emel
E
Yuksel
Sirin
S
Badur
Selim
S
D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000821:virology*; D004196:Disease Outbreaks; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics*; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D009154:Mutation; D014421:Turkey / Q000453:epidemiology