Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice.
We evaluated tissue changes associated with cerium chloride administration via gavage to adult mice, via milk to neonatal mice and transplacentally to fetal mice. Change in adults consisted of extensive pulmonary hemorrhage, pulmonary venous congestion, thickened alveolar septae, hepatic necrosis and neutrophil infiltrations. Those in fetal mice consisted of pulmonary and hepatic congestion. These results indicate that gavage cerium administration elicited subtle tissue changes, though oral toxicity is rather low. These changes were less severe in neonatal and fetal mice. When cerium was injected into adult mice through the tail vein, cerium was distributed mainly to the liver, spleen and lung dose-dependently with the cerium concentration gradually decreasing after 3 days. A study of cerium anticoagulation in mouse plasma showed that clotting time was significantly prolonged when cerium was added to plasma. These results suggest that cerium may disturb blood coagulation and cause pulmonary and hepatic vascular congestion.
Kawagoe
Masami
M
Department of Biochemistry, Akita University School of Medicine, Akita 010-8543, Japan.
Ishikawa
Kiyoshi
K
Wang
Shou-Cun
SC
Yoshikawa
Kiwamu
K
Arany
Szilvia
S
Zhou
Xiao-Ping
XP
Wang
Jing-Shu
JS
Ueno
Yasuharu
Y
Koizumi
Yukio
Y
Kameda
Takashi
T
Koyota
Souichi
S
Sugiyama
Toshihiro
T
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D002563:Cerium / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR
D000925:Anticoagulants; D002563:Cerium; C026690:cerous chloride