Catalytic alkene cyclohydroamination via an imido mechanism.
Chiral-at-metal half-sandwich diamide complexes catalyse enantioselective cyclohydroamination of aminoalkenes at unexpectedly high rates given their high coordination number and steric bulk; substantial evidence is presented which argues against the established sigma-bond insertion process and is strongly indicative of an imido [2+2] cycloaddition mechanism.
Gott
Andrew L
AL
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, UKCV4 7AL.
Clarke
Adam J
AJ
Clarkson
Guy J
GJ
Scott
Peter
P
D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
D000475:Alkenes; D007097:Imines; D009942:Organometallic Compounds; D015040:Zirconium