title: Anaplastic glioma after high-dose proton-photon radiation treatment for low-grade skull base chondrosarcoma.
abstract: We report the case of a 63-year-old man who developed an anaplastic oligoastrocytoma of the brain stem and midbrain 13 years after postoperative high-dose proton-photon radiation therapy for a recurrent low-grade chondrosarcoma of the skull base. To our knowledge, this is the first reported case of an anaplastic glioma after proton-photon irradiation.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
authors.forename: Sepehr
authors.initials: S
authors.lastname: Ehsani
authors.forename: Mojgan
authors.initials: M
authors.lastname: Hodaie
authors.forename: Norbert J
authors.initials: NJ
authors.lastname: Liebsch
authors.forename: Fred
authors.initials: F
authors.lastname: Gentili
authors.forename: Tim-Rasmus
authors.initials: TR
authors.lastname: Kiehl
mesh_terms: D020295:Brain Stem Neoplasms / Q000209:etiology*; D002813:Chondrosarcoma / Q000532:radiotherapy*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000209:etiology*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017785:Photons / Q000009:adverse effects* / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D019292:Skull Base Neoplasms / Q000532:radiotherapy*; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D016708:Synaptophysin