title: Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the saliva.
abstract: OBJECTIVE
  To evaluate the effect of psychotropics on stimulated salivary flow rate (SSFR), total proteins, urea and calcium concentration, alpha-amylase activity, pH, saliva buffer capacity (SBC), and the prevalence of xerostomia in psychotropic users and its relationship with low SSFR and/or hyposalivation.
  
  
  METHODS
  Thirty-three subjects were allocated to 4 groups: I (control): II (psychotropic users); III (subjects of group II using only selective serotonin reuptake inhibitors [SSRIs]); and IV (subjects of group II using SSRIs at recommended initial dose). The SBC was obtained by titrimetry and salivary composition by colorimetric method.
  
  
  RESULTS
  Group II presented a significant decrease (P = .0203), of 33.85% in SSFR compared with group I. Mean SSFR values in groups III and IV showed no significant difference compared with control group (P > .05). Xerostomia was observed in 37.50%, 38.46%, and 50% of subjects in groups II, III, and IV, respectively. Biochemical composition, pH, and SBC were not significantly affected (P > .05) by the use of psychotropics.
  
  
  CONCLUSIONS
  Xerostomia was associated with a decrease in SSFR and not with alterations in biochemical composition. Even when using the latest-generation drugs, there were complaints of xerostomia associated with decrease in SSFR.
authors.affiliation: Department of Stomatology, School of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
authors.forename: Patrícia Del Vigna
authors.initials: Pdel V
authors.lastname: de Almeida
authors.forename: Ana Maria Trindade
authors.initials: AM
authors.lastname: Grégio
authors.forename: João Armando
authors.initials: JA
authors.lastname: Brancher
authors.forename: Sérgio Aparecido
authors.initials: SA
authors.lastname: Ignácio
authors.forename: Maria Angela Naval
authors.initials: MA
authors.lastname: Machado
authors.forename: Antônio Adilson Soares
authors.initials: AA
authors.lastname: de Lima
authors.forename: Luciana Reis
authors.initials: LR
authors.lastname: Azevedo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D002021:Buffers; D003124:Colorimetry; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010812:Physical Stimulation; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012472:Salivation / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D018709:Statistics, Nonparametric; D017186:Titrimetry; D014987:Xerostomia / Q000139:chemically induced*; D000516:alpha-Amylases / Q000032:analysis
chemical_list: D000928:Antidepressive Agents; D001569:Benzodiazepines; D002021:Buffers; D012471:Salivary Proteins and Peptides; D017367:Selective Serotonin Reuptake Inhibitors; D000516:alpha-Amylases