Involvement of amlodipine, diazoxide, and glibenclamide in development of morphine tolerance in mice.
In this study, the effects of the calcium channel blocker (amlodipine), potassium channel opener (diazoxide), and potassium channel blocker (glibenclamide) on the development of morphine-induced tolerance in the formalin test was investigated. During development of tolerance to morphine, intraperitoneal (i.p.) administration of different doses of amlodipine (5, 7.5 and 10 mg/kg) or diazoxide (1, 5 and 10 mg/kg) in combination with morphine (20 and 30 mg/kg) increased tolerance in the first and second phase of the test. However, glibenclamide (2.5, 5, and 10 mg/kg) decreased morphine tolerance in the second phase of formalin test. It is concluded that calcium and potassium channel mechanisms may be involved in the morphine tolerance.
Khalilzadeh
Omid
O
Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Anvari
Mehdi
M
Khalilzadeh
Azita
A
Sahebgharani
Mousa
M
Zarrindast
Mohammad R
MR
D017311:Amlodipine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003981:Diazoxide / Q000008:administration & dosage / Q000494:pharmacology*; D004361:Drug Tolerance / Q000502:physiology*; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage*; D009294:Narcotics / Q000008:administration & dosage*; D009619:Nociceptors / Q000187:drug effects; D015221:Potassium Channels / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D007004:Hypoglycemic Agents; D009294:Narcotics; D015221:Potassium Channels; D014665:Vasodilator Agents; D017311:Amlodipine; D009020:Morphine; D003981:Diazoxide; D005905:Glyburide