title: Joint one-sided and two-sided simultaneous confidence intervals.
abstract: For the analysis of multiarmed clinical trials often a set consisting of a mixture of one- and two-sided tests can be preferred over a set of common two-sided hypotheses settings. Here we show the straightforward application of existing multiple comparison procedures for the difference and ratio of normally distributed means to complex trial designs, involving one and two test directions. The proposed contrast tests provide a more flexible framework than the existing methods at nearly similar power. An application is illustrated for an example with multiple treatment doses and two active controls; statistical software codes are included for R and SAS System.
authors.affiliation: Biometrics, N.V. Organon, Oss, The Netherlands Biometrics, Global Clinical Information.
authors.forename: S
authors.initials: S
authors.lastname: Braat
authors.forename: D
authors.initials: D
authors.lastname: Gerhard
authors.forename: L A
authors.initials: LA
authors.lastname: Hothorn
mesh_terms: D047072:Aromatase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data*; D016001:Confidence Intervals; D004359:Drug Therapy, Combination; D006801:Humans; D000077289:Letrozole; D015233:Models, Statistical; D009570:Nitriles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012107:Research Design; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D020845:Selective Estrogen Receptor Modulators; D014230:Triazoles; D013629:Tamoxifen; D000077289:Letrozole