Intrauterine growth restriction: fetal programming of hypertension and kidney disease.
The etiology of hypertension historically includes 2 components: genetics and lifestyle. However, recent epidemiologic studies report an inverse relationship between birth weight and hypertension suggesting that a suboptimal fetal environment may also contribute to increased disease in later life. Experimental studies support this observation and indicate that cardiovascular/kidney disease originates in response to fetal adaptations to adverse conditions during prenatal life.
Ojeda
Norma B
NB
Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Grigore
Daniela
D
Alexander
Barbara T
BT
D000818:Animals; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000503:physiopathology