Oral subchronic toxicity of a lipid extract from Roystonea regia fruits in mice.
D-004 is a lipid extract of royal palm (Rosytonea regia) fruits that prevents prostate hyperplasia induced with testosterone in rodents. Previous studies have shown no D-004-related toxicity in rats, but no study in mice had been reported. D-004 (500, 1000, and 2000 mg/kg) was evaluated in a subchronic (eight weeks) study in NMRI mice. No evidences of treatment-related toxicity were detected. Thus, body-weight gain, clinical observations, food consumption, blood biochemical, hematology, organ-weight ratios, and histopathological findings were similar in control and treated groups. This study supports that D-004 orally administered up to 2000 mg/kg did not induce treatment-related toxicity.
Gutiérrez
Adriadne
A
Toxicology Department, Natural Products Center, National Center for Scientific Research, Havana City, Cuba.
Gámez
Rafael
R
Mas
Rosa
R
Noa
Miriam
M
Pardo
Balia
B
Marrero
Gisela
G
Pérez
Yohany
Y
González
Rosa
R
Curveco
Dayisell
D
García
Haydee
H
D000284:Administration, Oral; D000818:Animals; D028023:Arecaceae / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D036401:Toxicity Tests, Chronic
C504503:D 004 extract; D010936:Plant Extracts