title: Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst.
abstract: A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kano
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ueda
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013237:Stereoisomerism; D013388:Succinimides / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000605:Amino Alcohols; D013388:Succinimides; C008155:N-iodosuccinimide