title: Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis.
abstract: OBJECTIVE
  To test the safety and efficacy of biphosphonates in chronic recurrent multifocal osteomyelitis (CRMO).
  
  
  METHODS
  Five patients with CRMO, all of whom had ongoing pain and loss of function despite conventional treatment with non-steroidal anti-inflammatory agents, were treated with pamidronate (1 mg/kg/dose with a dosing frequency of 2 to 4 monthly for a total treatment duration of 12 to 42 months).
  
  
  RESULTS
  Pain decreased after the first infusion for 4 of 5 patients, with symptomatic improvement maintained with time. Significant improvement was seen in radiological lesions for these 4 patients.
  
  
  CONCLUSIONS
  Bisphosphonates appear to be a useful and safe adjunctive treatment in CRMO when simple therapies such as anti-inflammatory agents fail to control symptoms or cases in which lesion expansion continues.
authors.affiliation: Royal Children's Hospital, Melbourne, Australia. peter.simm@rch.org.au
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Simm
authors.forename: Roger C
authors.initials: RC
authors.lastname: Allen
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Zacharin
mesh_terms: D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy*; D000077268:Pamidronate; D012008:Recurrence
chemical_list: D004164:Diphosphonates; D000077268:Pamidronate