Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate.
In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [(3)H]PGE(2) transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver.
Islam
Rafiqul
R
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan.
Anzai
Naohiko
N
Ahmed
Nesar
N
Ellapan
Babu
B
Jin
Chun Ji
CJ
Srivastava
Sunena
S
Miura
Daisaku
D
Fukutomi
Toshiyuki
T
Kanai
Yoshikatsu
Y
Endou
Hitoshi
H
D000818:Animals; D001692:Biological Transport; D015232:Dinoprostone / Q000378:metabolism; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D051379:Mice; D029362:Organic Anion Transporters, Sodium-Independent / Q000502:physiology*; D011422:Propionates / Q000378:metabolism*; D014981:Xenopus
D005232:Fatty Acids, Volatile; D029362:Organic Anion Transporters, Sodium-Independent; D011422:Propionates; C490281:Slc22a7 protein, mouse; D015232:Dinoprostone