title: ent-Kaurane Diterpenoids from Isodon nervosus.
abstract: A pentacyclic ent-kauranoid, nervonin A ( 1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J ( 2- 10), along with 10 known ones ( 11- 20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Li
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; C529410:nervonin A