Cytotoxic diterpenoids from Euphorbia helioscopia.
Four new jatrophane-type diterpenoids (1-4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1-4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa and MDA-MB-231 cells was evaluated, with only helioscopinolide A (5) and euphornin (3a) being active.
Lu
Zhi-Qiang
ZQ
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang, Shanghai, PR China.
Guan
Shu-Hong
SH
Li
Xing-Nuo
XN
Chen
Guang-Tong
GT
Zhang
Jin-Qiang
JQ
Huang
Hui-Lian
HL
Liu
Xuan
X
Guo
De-An
DA
D045784:Abietanes / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C530235:euphornin; C487257:helioscopinolide A