A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization.
Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor progression. In this issue of Cancer Cell, two papers, utilizing different tumor angiogenesis models, both find that activated MMP-9 delivered by BMDCs modulates neovessel remodeling, thereby promoting tumor growth. The changes in microvascular anatomy induced by MMP-9-expressing BMDCs are strikingly different between the preirradiated tumor vascular bed model employed by Ahn and Brown and the invasive glioblastoma model utilized by Du et al., likely mirroring the complexity of the real tumor microenvironment and the intricacy of roles of different BMDC populations in mediating tumor neoangiogenesis.
Seandel
Marco
M
Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA. seandelm@mskcc.org
Butler
Jason
J
Lyden
David
D
Rafii
Shahin
S
D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D001854:Bone Marrow Cells / Q000201:enzymology*; D016026:Bone Marrow Transplantation; D015687:Cell Hypoxia; D002465:Cell Movement; D042783:Endothelial Cells / Q000201:enzymology; D005909:Glioblastoma / Q000098:blood supply / Q000201:enzymology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000201:enzymology* / Q000637:transplantation; D022423:Myeloid Cells / Q000201:enzymology* / Q000637:transplantation; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000201:enzymology* / Q000473:pathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000201:enzymology* / Q000473:pathology / Q000517:prevention & control; D015398:Signal Transduction; D013234:Stem Cells / Q000201:enzymology; D013997:Time Factors
D042501:Angiogenic Proteins; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse