title: Abortive or minimal-growth hemangiomas: Immunohistochemical evidence that they represent true infantile hemangiomas.
abstract: BACKGROUND
  Infantile hemangiomas have a characteristic natural history of rapid proliferation in the first weeks of life followed by spontaneous involution. At birth, they may be present as a precursor lesion. Sometimes one may see precursor lesions that never undergo a growth phase or that undergo minimal growth. It is unclear the exact nature of these precursor-like lesions.
  
  
  OBJECTIVE
  We sought to describe the morphology and histopathology of these precursor-like lesions.
  
  
  METHODS
  We describe 4 patients with macules resembling precursor lesions of hemangiomas that did not show proliferation phase or minimal growth. The histopathologic and immunohistochemical study with glucose transporter-1 was performed in all of these cases.
  
  
  RESULTS
  The skin biopsy specimen showed superficial ectatic vessels that reacted with anti-glucose transporter-1 antibodies. All skin biopsy specimens exhibited capillary lobules in papillary dermis and, in two of them, in the reticular dermis and subcutis.
  
  
  CONCLUSIONS
  This text is limited by the number of cases reported.
  
  
  CONCLUSIONS
  Precursor lesions of hemangioma that do not show proliferation phase or minimal growth represent, in the view of glucose transporter-1 immunoreactivity, true hemangiomas of infancy with an aborted or arrested growth cycle.
authors.affiliation: Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Corella
authors.forename: Xavier
authors.initials: X
authors.lastname: Garcia-Navarro
authors.forename: Adriana
authors.initials: A
authors.lastname: Ribe
authors.forename: Agustin
authors.initials: A
authors.lastname: Alomar
authors.forename: Eulalia
authors.initials: E
authors.lastname: Baselga
mesh_terms: D002675:Child, Preschool; D005260:Female; D051272:Glucose Transporter Type 1 / Q000276:immunology; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D007223:Infant; D013684:Telangiectasis / Q000473:pathology
chemical_list: D051272:Glucose Transporter Type 1