Central neurocytoma responsive to topotecan, ifosfamide, carboplatin.
A 5-year-old male presented with spinal cord drop metastasis from a recurrent neurocytoma. Topotecan (0.5 mg/m(2)) and carboplatin (250 mg/m(2)) were administered on days 1-3 and ifosfamide (1,800 mg/m(2)) on days 1-5, every 21 days, for three cycles and resulted in complete response without severe complications. A literature review yielded 20 patients with central neurocytoma but no complete responses. The complete response of central neurocytoma to chemotherapy only reported here should be helpful to those caring for patients with this rare tumor.
Amini
Elham
E
Department of Pediatrics, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Roffidal
Tina
T
Lee
Alice
A
Fuller
Gregory N
GN
Mahajan
Anita
A
Ketonen
Leena
L
Kobrinsky
Nathan
N
Cairo
Mitchell S
MS
Wells
Robert J
RJ
Wolff
Johannes E A
JE
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin; D002675:Child, Preschool; D018572:Disease-Free Survival; D006801:Humans; D007069:Ifosfamide; D008279:Magnetic Resonance Imaging; D008297:Male; D018306:Neurocytoma / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction; D019772:Topotecan
D019772:Topotecan; D016190:Carboplatin; D007069:Ifosfamide