title: Piggybacking schistosome invasion: similarities are only skin deep.
abstract: Schistosomes cause significant morbidity and mortality. In this article, we discuss recent findings regarding how different schistosome species infect and manipulate immune responses in their hosts through the evolution and use of different protease classes. The advent of transgenic schistosomes is explored in relation to the biology of these important molecules.
authors.affiliation: Institute of Genetics, Queens Medical Centre, Nottingham NG7 2UH, UK. richard.pleass@nottingham.ac.uk <richard.pleass@nottingham.ac.uk>
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Pleass
authors.forename: A Aziz
authors.initials: AA
authors.lastname: Aboobaker
authors.forename: Armin O
authors.initials: AO
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006790:Host-Parasite Interactions / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D008967:Molecular Biology; D030781:Organisms, Genetically Modified; D010447:Peptide Hydrolases / Q000378:metabolism; D012547:Schistosoma / Q000201:enzymology / Q000472:pathogenicity*; D012552:Schistosomiasis / Q000469:parasitology* / Q000635:transmission; D012697:Serine Endopeptidases / Q000378:metabolism
chemical_list: D010447:Peptide Hydrolases; D012697:Serine Endopeptidases