Macrolactin S, a novel macrolactin antibiotic from marine Bacillus sp.
A new 24-membered ring lactone, macrolactin S, was isolated from a culture broth of marine Bacillus sp. and its structure was established by various spectral analyses. Macrolactin S is the first macrolactin hydroxylated at C-12. Besides, the known compounds macrolactin A and macrolactin B were also isolated, which were elucidated on the basis of spectral data analyses and literature data comparison. They exhibited antibacterial activity against E. coli and S. aureus.
Lu
X L
XL
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, PR China.
Xu
Q Zh
QZh
Shen
Y H
YH
Liu
X Y
XY
Jiao
B H
BH
Zhang
W D
WD
Ni
K Y
KY
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D018942:Macrolides; C532687:macrolactin S