title: [In vitro susceptibility of isolates of Scytalidium spp. from superficial lesions against posaconazole].
abstract: Scytalidium spp. is a dematiaceous fungi that has been frequently reported from tropical to semi subtropical regions. We distinguish two pathogenic species: S. dimidiatum and S. hyalinum which is an homologous non-pigmented mutant of S. dimidiatum. This keratinophilic mold may produce superficial disease (skin, nails) indistinguishable from dermatophytes. In Martinique, this pseudodermatophyte could represent more than 50 % of onychomycosis. Contrary to dermatophytes, the clinical response of Scytalidium spp. are typically very poor and topical treatment or systemic agents ineffective. To evaluate the potential efficacy of the new antifungal agent posaconazole, we tested in vitro 12 clinical isolates of Scytalidium spp. (seven S. dimidiatum and five S. hyalinum) against posaconazole by Etest method. For the totality of the isolates, the minimum inhibitory concentrations (MICs) were low: MICs less or equal to 0.25 microg/ml (maximum MICs of 0.25 microg/ml for S. dimidiatum and 0.032 microg/ml for S. hyalinum). These in vitro efficacy suggest that the new agent posaconazole may be a future alternative treatment.
authors.affiliation: Laboratoire de microbiologie, hôpital Ambroise-Paré, Boulogne-Billancourt, France.
authors.forename: J
authors.initials: J
authors.lastname: Dunand
authors.forename: A
authors.initials: A
authors.lastname: Paugam
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects* / Q000302:isolation & purification; D003881:Dermatomycoses / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005533:Foot Dermatoses / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000302:isolation & purification; D014009:Onychomycosis / Q000382:microbiology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole