Innate recognition of non-self nucleic acids.
The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.
Chi
Hongbo
H
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. hongbo.chi@stjude.org
Flavell
Richard A
RA
D001327:Autoimmune Diseases / Q000276:immunology*; D003600:Cytosol / Q000276:immunology; D004247:DNA / Q000276:immunology*; D011992:Endosomes / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D012313:RNA / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000502:physiology*
D051192:Receptors, Pattern Recognition; D012313:RNA; D004247:DNA