Synthesis of aminoalkanol derivatives of 4-hydroxy-1,7,8,9,10-pentamethyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione as potential beta-adrenolytics.
A series of aminoalkanol derivatives of 4-hydroxy-1,7,8,9,10-pentamethyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione have been prepared. The pharmacological profile of selected compounds was evaluated for their affinities at beta-adrenoreceptors.
Struga
Marta
M
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.
Kossakowski
Jerzy
J
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D011943:Receptors, Adrenergic, beta