title: [Neurofibroma of thyroid in a patient with neurofibromatosis type 1].
abstract: The neurofibromatosis type 1 (NF1), also known as von Recklinghausens disease, is an autosomal dominant disorder, with high degree of variability of clinical expression, usually involved with formation of tumors, with benign origin in the majority of cases mainly localized in the region of the head and neck and rarely incident in the thyroid area. However, the association with medullary carcinoma of the thyroid (MCT) exists in literature and needs to be excluded. We report a case of a patient with NF1, nonfunctional thyroid nodule and obstructive symptoms. Surgical resection of lesion was performed, with histopathologic findings compatible with neurofibroma in thyroid tissue. This case is relevant not only because of the rarity of the presentation of NF1, but also due to the likely association with MCT, an aggressive tumor that can be cured by surgery.
authors.affiliation: Serviço de Clínica Médica, Hospital Universitário, Universidade Federal de Santa Maria, RS, Brazil. mateusdsevero@pop.com.br
authors.forename: Mateus Dornelles
authors.initials: MD
authors.lastname: Severo
authors.forename: Verônica Denardin da
authors.initials: VD
authors.lastname: Rosa
authors.forename: Diego Michelon
authors.initials: DM
authors.lastname: De Carli
authors.forename: Maristela de Oliveira
authors.initials: Mde O
authors.lastname: Beck
authors.forename: Melissa Falster
authors.initials: MF
authors.lastname: Danbermam
mesh_terms: D000328:Adult; D001706:Biopsy; D018276:Carcinoma, Medullary / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009455:Neurofibroma / Q000473:pathology* / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D016606:Thyroid Nodule / Q000473:pathology