title: The influence of isocyanurate content on the bioperformance of hydrocarbon-based polyurethanes.
abstract: Bulk, surface and bioactivity of newly synthesized hydroxy telechelic polyisoprene-based (H-HTPI) polyurethane were investigated by means of ATR-FT-IR, contact-angle measurements, cell viability, calcification, and platelet and fibrinogen quantification. The influence of isophorone diisocyanates isocyanurate (I-IPDI) content on these properties was determined. Results generally showed a non-significant difference in these properties when they were compared with a commercially available biomedical polyurethane (PU), such as Tecoflex. Unexpectedly, where the increase of isocyanate content for commercial diisocyanate-based biocompatible PU significantly increases the surface contact angle, the new hydroxy telechelic polyisoprene-based PU showed a decrease of water contact angle with increasing I-IPDI content in the polymer. Nevertheless, the overall surface exhibited hydrophobic properties, i.e., theta > 85. Polymer cytotoxicity, assessed with L929 cell line in direct contact with the surface of the samples, showed no toxic effects on the cells. Interestingly, regardless of the I-IPDI content, platelet adhesion and fibrinogen adsorption, as well as the mineral deposition were fairly similar for all synthesized PUs. Our findings revealed that replacing diisocyanates by their isocyanurate homologues is a very relevant approach for preparation of polyurethanes with different mechanical properties while maintaining similar surface properties.
authors.affiliation: UMR 6522 CNRS-Polymères Biopolymères Membranes, L2M, INSA de Rouen, Mont-Saint-Aignan cedex, France. fabrice.burel@insa-rouen.fr
authors.forename: F
authors.initials: F
authors.lastname: Burel
authors.forename: L
authors.initials: L
authors.lastname: Poussard
authors.forename: M
authors.initials: M
authors.lastname: Tabrizian
authors.forename: Y
authors.initials: Y
authors.lastname: Merhi
authors.forename: C
authors.initials: C
authors.lastname: Bunel
mesh_terms: D000042:Absorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002113:Calcification, Physiologic / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D006838:Hydrocarbons / Q000737:chemistry*; D015539:Platelet Activation / Q000187:drug effects; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D006838:Hydrocarbons; D011140:Polyurethanes; D014227:Triazines; C509473:isocyanuric acid; D005340:Fibrinogen