A new diaryheptanoid from the bark of Myrica rubra.
A new diarylheptanoid, (11 xi)-3,5-dimethoxy-11,17-dihydroxy-4,19-diketo-[7,0]-metacyc- lophane, named as rubanol 1, was isolated from the bark of Myrica rubra along with four known compounds (2-5). Their structures were determined by spectroscopic methods including 1D, 2D NMR or comparison with authentic samples. Compound 1 exhibited cytotoxicity against Lun-06, Neu-04, and Bre-04 cell lines with GI50 values of 16.03-32.58 microg mL(-1).
Wang
Ding-Yong
DY
Guangdong Pharmaceutical University, College of Pharmacy, Guangdong Pharmaceutical University, Higher Education Mega Center, Guangdong, PR China. wdingyong@163.com
Liu
En-Gui
EG
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry*; D015394:Molecular Structure; D031641:Myrica / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; C532685:rubanol