Scintigraphic evaluation of gallbladder motor functions in H pylori positive and negative patients in the stomach with dyspepsia.
OBJECTIVE
To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach.


METHODS
All cases (86) underwent the 14C urea breath test (UBT). 14C-UBT was found as positive in 58 and negative in 28 dyspeptic patients. 14C-UBT was accepted as a gold standard test. Clo test and histopathologic examination were compared with the results of 14C-UBT in cases who tolerated upper gastrointestinal endoscopy procedure. Cholescintigraphy with 99mTc-mebrofenin was used to determine the parameters of GB motor function (GB filling and emptying time, half of the emptying time, ejection fraction at 30th and 60th min) in all patients.


RESULTS
We found the sensitivity and specificity as 88% and 86% for Clo test and as 89% and 80% for histologic evaluation, respectively. The parameters of GB function were not significantly different in H pylori positive and negative patients. The GB emptying was normal in both groups. Minimum GB filling time was 30 min in 34 of 86 cases (39.5%), filling was not observed in 2 cases. The GB ultrasonography (USG) results were normal for all cases and bile composition abnormality was not determined.


CONCLUSIONS
Our study showed that 14C-UBT is highly reliable method to detect the presence of H pylori. The presence of H pylori infection does ot directly affect the GB function.
Yaylali
Olga Taskaya
OT
Department of Nuclear Medicine, Pamukkale University, School of Medicine, Doktorlar Caddesi No. 42, Denizli 20100, Turkey. olgataskaya@yahoo.com
Yilmaz
Mustafa
M
Kiraç
Fatma Suna
FS
Değirmencioğlu
Serkan
S
Akbulut
Metin
M
D000328:Adult; D001944:Breath Tests; D002250:Carbon Radioisotopes; D016022:Case-Control Studies; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D005704:Gallbladder / Q000503:physiopathology*; D005746:Gastric Emptying / Q000502:physiology; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000379:methods; D012680:Sensitivity and Specificity; D013270:Stomach / Q000382:microbiology*; D013272:Stomach Diseases / Q000503:physiopathology*; D013667:Technetium; D014508:Urea / Q000378:metabolism
D002250:Carbon Radioisotopes; D013667:Technetium; D014508:Urea