Comparison of the cardiovascular effects of isoflurane and sevoflurane as measured by magnetic resonance imaging in children with congenital heart disease.
OBJECTIVE
To compare the cardiovascular effects of isoflurane and sevoflurane at minimum alveolar concentration (MAC) = 1 in children with congenital heart disease using cardiac magnetic resonance imaging.


METHODS
Randomized, crossover, single-blinded study.


METHODS
Tertiary-care teaching hospital.


METHODS
10 pediatric patients with congenital heart diseases scheduled to undergo cardiac magnetic resonance studies.


METHODS
Patients were randomized to receive either isoflurane or sevoflurane as the "first inhalation agent." After a period or more than 20 minutes, they were crossed over to receive the "second inhalation agent."


METHODS
Heart rate, mean arterial pressure (MAP), cardiac index, stroke volume index, and ejection fraction (EF) at one MAC for both agents were all recorded.


RESULTS
Both isoflurane and sevoflurane caused a significant decrease in MAP from the baseline (P = 0.013). The mean values (+/-SD) of stroke volume (mL), cardiac index (L min(-1) m(-2)), and EF (%) for isoflurane versus sevoflurane were 21.5 (+/-9.2) versus 19.6 (+/-6.2), 4.1 (+/-1.2) versus 3.7 (+/-0.87), and 64.2 (+/-14.5) versus 62.5 (+/-13.8), respectively.


CONCLUSIONS
Both isoflurane and sevoflurane were found to be comparable in terms of cardiovascular effects.
Dalal
Priti G
PG
Department of Anesthesiology, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA. pdalal@hmc.psu.edu
Corner
Andrew
A
Chin
Chris
C
Wood
Carine
C
Razavi
Reza
R
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D006330:Heart Defects, Congenital; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007530:Isoflurane / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008738:Methyl Ethers / Q000494:pharmacology*; D012107:Research Design; D012121:Respiration, Artificial; D000077149:Sevoflurane; D016037:Single-Blind Method
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane