title: Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele.
abstract: We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival. When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men.
authors.affiliation: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Giannattasio
authors.forename: Anna
authors.initials: A
authors.lastname: Poleggi
authors.forename: Maria
authors.initials: M
authors.lastname: Puopolo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pocchiari
authors.forename: Piero
authors.initials: P
authors.lastname: Antuono
authors.forename: Gloria
authors.initials: G
authors.lastname: Dal Forno
authors.forename: David R
authors.initials: DR
authors.lastname: Wekstein
authors.forename: Maria G
authors.initials: MG
authors.lastname: Matera
authors.forename: Davide
authors.initials: D
authors.lastname: Seripa
authors.forename: Adele
authors.initials: A
authors.lastname: Acciarri
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bizzarro
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lauria
authors.forename: Carlo
authors.initials: C
authors.lastname: Masullo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000401:mortality*; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006579:Heterozygote; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics*; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions