Early neuropsychological detection and the characteristics of Parkinson's disease associated with mild dementia.
Parkinson's disease (PD) may exhibit patterns of cognitive deficits, yet physicians are currently lacking operational criteria to define the clinical boundaries between PD and PD dementia (PDD). Therefore, we investigated the characteristics of the cognitive impairments in mild PDD. We recruited 30 PDD, 20 PD-MCI (PD with mild cognitive impairment without dementia) and 33 controls. All subjects were evaluated with detailed neuropsychological tests. Our results showed that visual memory, visuospatial functions, naming and calculation displayed more marked impairment than that of the other domains. Thus we suggest that adding cognitive dysfunctions of cortical type to the early cognitive deficits of PD-MCI can help predict the development of dementia.
Song
In-Uk
IU
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim
Joong-Seok
JS
Jeong
Du-Shin
DS
Song
Hyun-Joo
HJ
Lee
Kwang-Soo
KS
D000368:Aged; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D003704:Dementia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications*; D011340:Problem Solving / Q000502:physiology; D011446:Prospective Studies; D012189:Retrospective Studies; D013028:Space Perception / Q000502:physiology