Strategy for utilization of new antiepileptic drugs.
OBJECTIVE
The paper reviews strategies to incorporate new antiepileptic drugs into the treatment arsenal for patients with epilepsy.


RESULTS
Ten new antiepileptic drugs have been developed in the last two decades, making selection of optimal therapy complex; they have not been shown to have better efficacy but generally seem to be better tolerated. Newer antiepileptic drugs offer new opportunities to patients who have not had a favorable response to the old ones. Many new antiepileptic drugs exhibit a broad spectrum of activity while only one of the older ones (valproate) has a broad-spectrum profile. There are therefore more choices when trying to match treatment with epileptic seizures and syndromes. The side-effect profiles of the newer antiepileptic drugs differ from the older ones with fewer systemic reactions and better pharmacokinetics for the most part.


CONCLUSIONS
Comparative studies are needed to elucidate the specific weaknesses and strengths of each of the new antiepileptic drugs compared with the older ones. Most clinical trials do not help the physician in deciding drug, dose, or titration schedules. Thus the physician needs to understand efficacy spectrum and side-effect profiles of each new antiepileptic drug in order to be able to treat each patient optimally.
Ben-Menachem
Elinor
E
Institute for Clinical Neuroscience and Rehabilitation, Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg, Sweden. ebm@neuro.gu.se
D000367:Age Factors; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002648:Child; D004351:Drug Resistance / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009480:Neuropharmacology / Q000379:methods* / Q000639:trends*; D018579:Patient Selection; D011247:Pregnancy; D012737:Sex Factors; D016896:Treatment Outcome
D000927:Anticonvulsants