title: Do different disorders in cell cycle regulation account for different biological behavior of urothelial and sinonasal inverted papillomas?
abstract: OBJECTIVE
  It was the aim of this study to assess the expression of selected cell cycle regulation genes in urothelial and sinonasal inverted papillomas (IP).
  
  
  METHODS
  Archived surgically resected specimens from 18 urothelial and 19 sinonasal IP were studied immunohistochemically for p16, p53, cyclin D1 and Ki67. Staining results were semiquantified and compared between IP and adjacent control mucosa (CM).
  
  
  RESULTS
  p53 expression did not differ between sinonasal and urothelial IP. Although there was a trend of higher p53 expression in IP compared with the adjacent CM in sinonasal and urothelial specimens, this trend failed to be statistically significant. p16 expression was significantly higher in urothelial IP and CM in comparison with their sinonasal counterparts, but did not differ significantly between IP and its adjacent CM either in urothelial or sinonasal specimens. There were no significant differences in the mean scores for cyclin D1 or Ki67.
  
  
  CONCLUSIONS
  The changes in p53 expression seen in both types of IP compared with adjacent CM suggest that sinonasal and urothelial IP may share some common ground in terms of their evolution. Although p16 appears not to be directly involved in the development of sinonasal or urothelial IP, the differing recurrence patterns of sinonasal versus urothelial IP may be attributable in part to different p16 expression.
authors.affiliation: Institute of Pathology, HELIOS Klinikum Bad Saarow, Charité University Medicine Teaching Hospital, Bad Saarow, Germany. sven.gunia@helios-kliniken.de
authors.forename: S
authors.initials: S
authors.lastname: Gunia
authors.forename: F
authors.initials: F
authors.lastname: Fritzsche
authors.forename: M
authors.initials: M
authors.lastname: May
authors.forename: D
authors.initials: D
authors.lastname: Liebe
authors.forename: S
authors.initials: S
authors.lastname: Koch
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D019938:Cyclin D1 / Q000378:metabolism; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019459:Urothelium / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1