Emissive terbium probe for multiphoton in vitro cell imaging.
A polymeric terbium complex that can be excited by near-infrared excitation at 800 nm via multiphoton absorption processes has been synthesized. This complex has been demonstrated to show strong, observable, three-photon-induced f-f emission in cell imaging. In vitro studies carried out in three carcinoma cell lines (A549, HONE1, and HeLa) have been performed and shown to have low cytotoxicity. This complex is therefore a potential candidate for future infrared excitation imaging dyes.
Law
Ga-Lai
GL
Department of Chemistry, the University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Wong
Ka-Leung
KL
Man
Cornelia Wing-Yin
CW
Wong
Wing-Tak
WT
Tsao
Sai-Wah
SW
Lam
Michael Hon-Wah
MH
Lam
Paul Kwan-Sing
PK
D002277:Carcinoma / Q000378:metabolism*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods*; D008024:Ligands; D018613:Microscopy, Confocal / Q000295:instrumentation / Q000379:methods; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017785:Photons; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods; D013725:Terbium / Q000737:chemistry*
D005456:Fluorescent Dyes; D008024:Ligands; D009942:Organometallic Compounds; D011108:Polymers; D013725:Terbium