title: [Case of idiopathic bronchiolitis obliterans successfully treated by medication].
abstract: A 53-year-old woman visited a clinic for stridor and dyspnea, and was treated with steroid and heparin for bronchial asthma and pulmonary embolism. She was later admitted to our hospital for progressive dyspnea. Blood gas analysis showed severe hypoxemia with hypercapnia. Pulmonary funtion tests revealed severe obstractive pulmonary dysfunction. Chest computed tomography showed a mosaic perfusion pattern. Ventilation-perfusion scanning showed bilateral multiple matched defects, especially in the basal region. Since specimens of Video-assisted thoracoscopic surgical (VATS) lung biopsy showed lymphocytic infiltration in membranous bronchiole and occlusion of the membranous bronchiole lumen, bronchiolitis obliterans was diagnosed. We initiated treatment with steroids, macrolides and bronchodilators and her condition stabilized. Although these therapies did not cure the BO, they did retard its progression.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hirose
authors.forename: Susumu
authors.initials: S
authors.lastname: Fukahori
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawano
authors.forename: Chizu
authors.initials: C
authors.lastname: Fukushima
authors.forename: Hiroto
authors.initials: H
authors.lastname: Matsuse
authors.forename: Nobuko
authors.initials: N
authors.lastname: Matsuo
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage / Q000031:analogs & derivatives; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000628:therapy*; D017291:Clarithromycin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D011239:Prednisolone / Q000008:administration & dosage*; D020775:Thoracic Surgery, Video-Assisted; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; C065857:beclomethasone 17-monopropionate; D011239:Prednisolone; D017291:Clarithromycin; D001507:Beclomethasone