title: Synthesis of 1-{4-[4-(adamant-1-yl)phenoxymethyl]-2-(4-bromophenyl)- 1,3-dioxolan-2-ylmethyl}imidazole with expected antifungal and antibacterial activity.
abstract: A multistep synthesis of a new analogue of ketoconazole, which was expected to show antifungal and antibacterial activity, has been described.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
authors.forename: Dariusz A
authors.initials: DA
authors.lastname: Płachta
authors.forename: Andrzej M
authors.initials: AM
authors.lastname: Baranowski
authors.forename: Agnieszka E
authors.initials: AE
authors.lastname: Laudy
authors.forename: Bohdan J
authors.initials: BJ
authors.lastname: Starościak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kleps
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004347:Drug Interactions; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: C528078:1-(4-(4-(adamant-1-yl)phenoxymethyl)-2-(4-bromophenyl)-1,3-dioxolan-2-ylmethyl)imidazole; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007093:Imidazoles; D000218:Adamantane