title: Effect of exercise on rate pressure product in premenopausal and postmenopausal women with coronary artery disease.
abstract: Incidence of coronary artery disease (CAD) increases sharply after menopause in women. Rate pressure product (RPP) is a major determinant of cardiac oxygen consumption. It is an important indicator of ventricular function. RPP varies with exercise. The peak rate pressure product (PRPP) which gives an accurate reflection of the myocardial oxygen demand and myocardial workload is the RPP at peak of exercise. The higher the PRPP, the more will be myocardial oxygen consumption (MVO2). The ability to reach higher PRPP is associated with more adequate coronary perfusion. Thus the low value of PRPP suggests significant compromise of coronary perfusion and decreased left ventricular function. In the present study effect of exercise on RPP of pre and postmenopausal women with CAD was compared. The percentage increase in RPP was significantly more in postmenopausal women with CAD (62%) as compared to premenopausal women with CAD (54%) indicating more compromised coronary perfusion in postmenopausal women.
authors.affiliation: Department of Physiology, Dayanand Medical College and Hospital, Ludhiana.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Nagpal
authors.forename: Lily
authors.initials: L
authors.lastname: Walia
authors.forename: Hem
authors.initials: H
authors.lastname: Lata
authors.forename: Naresh
authors.initials: N
authors.lastname: Sood
authors.forename: G K
authors.initials: GK
authors.lastname: Ahuja
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D003324:Coronary Artery Disease / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D017698:Postmenopause / Q000502:physiology*; D017697:Premenopause / Q000502:physiology*