HPV type infection in different anogenital sites among HIV-positive Brazilian women.
OBJECTIVE
To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV).


OBJECTIVE
Compare the prevalence of different HPV types and the risk factors for HPV positivity in three sites.


RESULTS
The most frequently detected HPV types in all sites were, in decreasing order, HPV16, 53, 18, 61 and 81. Agreement between the cervix and vagina was good (kappa 0.60 - 0.80) for HPV16 and 53 and excellent (Kappa > 0.80) for HPV18 and 61. HPV positivity was inversely associated with age for all combinations including the anal site.


CONCLUSIONS
In HIV positive women, HPV18 is the most spread HPV type found in combinations of anal and genital sites. The relationship of anal to genital infection has implications for the development of anal malignancies. Thus, the efficacy of the current HPV vaccine may be considered not only for the cervix, but also for prevention of HPV18 anal infection among immunossuppressed individuals.
Gonçalves
Maria Alice G
MA
Division of Clinical Immunology, University of São Paulo, São Paulo, Brazil. epigin@uol.com.br
Randi
Giorgia
G
Arslan
Annie
A
Villa
Luisa L
LL
Burattini
Marcelo N
MN
Franceschi
Silvia
S
Donadi
Eduardo Antonio
EA
Massad
Eduardo
E