title: Synthesis of UDP-glucose derivatives modified at the 3-OH as potential chain terminators of beta-glucan biosynthesis.
abstract: A series of UDP-D-glucose derivatives and precursors that have been modified at C-3 were synthesised from D-glucose as potential chain terminators of beta-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.
authors.affiliation: Chemistry Research Laboratory, Department of Plant Sciences, Oxford University, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Ramona
authors.initials: R
authors.lastname: Danac
authors.forename: Lucy
authors.initials: L
authors.lastname: Ball
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Gurr
authors.forename: Antony J
authors.initials: AJ
authors.lastname: Fairbanks
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects* / Q000502:physiology; D014532:Uridine Diphosphate Glucose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047071:beta-Glucans / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D047071:beta-Glucans; C033363:beta-1,3-glucan; D014532:Uridine Diphosphate Glucose