Toxicodynamic assumptions in ecotoxicological hazard models.
Existing toxicokinetic and toxicodynamic models and dynamic formulations of popular ecotoxicological concepts (e.g., the critical body residue concept) are examined. Their underlying assumptions about speed of recovery and thresholds are clarified, and a rigorous mathematical treatment shows that they can all be placed within a unifying framework. Such analysis aids in the selection of appropriate ecotoxicological models.
Ashauer
Roman
R
Eawag-Aquatic Research, Uberlandstrasse 133, 8600 Dübendorf, Switzerland. roman.ashauer@eawag.ch
Brown
Colin D
CD
D000818:Animals; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D015233:Models, Statistical; D008962:Models, Theoretical; D016016:Proportional Hazards Models; D018570:Risk Assessment; D014116:Toxicology / Q000379:methods
D004785:Environmental Pollutants