title: Cost-saving treatment strategies in in vitro fertilization: a combined economic evaluation of two large randomized clinical trials comparing highly purified human menopausal gonadotropin and recombinant follicle-stimulating hormone alpha.
abstract: OBJECTIVE
  To assess the cost-effectiveness of two gonadotropin treatments that are available in the United Kingdom in light of limited public funding and the fundamental role of costs in IVF treatment decisions.
  
  
  METHODS
  An economic evaluation based on two large randomized clinical trials in IVF patients using a simulation model.
  
  
  METHODS
  Fifty-three fertility clinics in 13 European countries and Israel.
  
  
  METHODS
  Women indicated for treatment with IVF (N = 986), aged 18-38, participating in double-blind, randomized controlled trials.
  
  
  METHODS
  Highly purified menotropin (HP-hMG, Menopur) or recombinant follitropin alpha (rFSH, Gonal-F).
  
  
  METHODS
  Cost per IVF cycle and cost per live birth for HP-hMG and rFSH alpha.
  
  
  RESULTS
  HP-hMG was more effective and less costly versus rFSH for both IVF cost per live birth and for IVF cost per baby (incremental cost-effectiveness ratio was negative). The mean costs per IVF treatment for HP-hMG and rFSH were 2408 pounds (95% confidence interval [CI], 2392 pounds, 2421 pounds) and 2660 pounds (95% CI 2644 pounds, 2678 pounds), respectively. The mean cost saving of 253 pounds per cycle using HP-hMG allows one additional cycle to be delivered for every 9.5 cycles.
  
  
  CONCLUSIONS
  Treatment with HP-hMG was dominant compared with rFSH in the United Kingdom. Gonadotropin costs should be considered alongside live-birth rates to optimize outcomes using scarce health-care resources.
authors.affiliation: Health Economics, Cardiff Research Consortium, Cardiff, United Kingdom.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Wechowski
authors.forename: Mark
authors.initials: M
authors.lastname: Connolly
authors.forename: Dirk
authors.initials: D
authors.lastname: Schneider
authors.forename: Philip
authors.initials: P
authors.lastname: McEwan
authors.forename: Richard
authors.initials: R
authors.lastname: Kennedy
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D003198:Computer Simulation; D017046:Cost Savings / Q000379:methods; D003362:Cost-Benefit Analysis; D004311:Double-Blind Method; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics* / Q000379:methods; D015292:Glycoprotein Hormones, alpha Subunit / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D015233:Models, Statistical; D011994:Recombinant Proteins / Q000191:economics / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015292:Glycoprotein Hormones, alpha Subunit; D011994:Recombinant Proteins; D008596:Menotropins