title: The impact of Creutzfeldt-Jakob disease on surgical practice.
abstract: Creutzfeldt-Jakob disease (CJD) is characterised by abnormal prion protein that can replicate and replace nervous tissue, with rapid lethal neurodegenerative consequences. The transmissible nature of CJD has been known for half a century and transmission has occurred through neurosurgical procedures. Variant Creutzfeldt-Jakob disease (vCJD) emerged in 1996, and the presence of abnormal prion in lymphatic tissue extended the number of surgical specialties dealing with infected material; transmission through blood transfusion raised the possibilities of a large carrier pool and spread of epidemic proportion. The abnormal prion is difficult to remove and this could influence future decontamination programmes. Contaminated instruments must be withdrawn from surgical practice, and this can interfere with the efficient running of a surgical unit and optimal patient care. There is an urgent need for reliable methods for the detection of abnormal prion, within and outside the body. These will help to clarify the epidemiology of CJD, and to reduce its transmission via blood and tissue. They will also allow determination of the efficacy of new decontamination products in surgical practice, and the value of any treatment of sufferers and carriers of CJD. In the meantime, continued vigilance and informed regulation of all aspects of CJD must remain.
authors.affiliation: jsplumley@yahoo.co.uk
authors.forename: John S P
authors.initials: JS
authors.lastname: Lumley
mesh_terms: D000818:Animals; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000635:transmission*; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D017410:Practice Guidelines as Topic; D011328:Prions / Q000472:pathogenicity; D012926:Social Control, Formal; D013525:Surgical Instruments / Q000382:microbiology; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D065227:Transfusion Reaction; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D011328:Prions