title: Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100.
abstract: BACKGROUND
  Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood.
  
  
  METHODS
  This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood.
  
  
  RESULTS
  Protein S-100 was significantly higher in neonates with umbilical artery blood pH<or=7.05, compared to neonates with pH>7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention.
  
  
  CONCLUSIONS
  A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor.
authors.affiliation: Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
authors.forename: Andrea
authors.initials: A
authors.lastname: Stuart
authors.forename: Linda
authors.initials: L
authors.lastname: Edvinsson
authors.forename: Karin
authors.initials: K
authors.lastname: Källen
authors.forename: Per
authors.initials: P
authors.lastname: Olofsson
authors.forename: Charlotte
authors.initials: C
authors.lastname: Hellsten
authors.forename: Isis
authors.initials: I
authors.lastname: Amer-Wåhlin
mesh_terms: D000138:Acidosis / Q000097:blood* / Q000209:etiology; D000328:Adult; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000209:etiology; D015148:Cardiotocography; D016022:Case-Control Studies; D004562:Electrocardiography / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000097:blood*; D011247:Pregnancy; D009418:S100 Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; D009418:S100 Proteins