title: Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study.
abstract: Using the British Columbia Linked Health Databases, we explored the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of developing Parkinson's disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. A time-dependent Cox model was used to estimate adjusted rate ratios for users and non-users of NSAIDs. The results of our study did not show a protective effect of NSAIDs for PD (rate ratio 0.84, 95% CI 0.81-1.09).
authors.affiliation: Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, British Columbia, Canada.
authors.forename: Mahyar
authors.initials: M
authors.lastname: Etminan
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Carleton
authors.forename: Ali
authors.initials: A
authors.lastname: Samii
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001955:British Columbia / Q000453:epidemiology; D002170:Canada; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal