title: Prognostic value of timing and duration characteristics of exercise oscillatory ventilation in patients with heart failure.
abstract: BACKGROUND
  Exercise oscillatory ventilation (EOV) occurs in a sub-group of patients with increased heart failure (HF) severity and poorer prognosis. The purpose of this investigation was to examine the prognostic value of the largest ventilatory oscillation characteristics in HF patients.
  
  
  METHODS
  One hundred fifty-four subjects diagnosed with HF underwent cardiopulmonary exercise testing. Subjects with EOV were then divided into two sub-groups: (1) largest ventilatory oscillation during the first half of exercise with an oscillation width > or =30 seconds; and (2) largest ventilatory oscillation during the second half of exercise or an oscillation width <30 seconds. Subjects were tracked for major cardiac events after the exercise test.
  
  
  RESULTS
  The fifty-five subjects (35.7%) in the overall group demonstrating EOV during the exercise test were at significantly higher risk for adverse events (hazard ratio = 3.0, 95% confidence interval 1.6 to 5.5, p < 0.001). The prognostic value of this ventilatory phenomenon improved when only subjects with the largest ventilatory oscillation during the first half of exercise with an oscillation width > or =30 seconds were defined as having EOV (hazard ratio = 3.6, 95% confidence interval 1.6 to 7.9, p = 0.002).
  
  
  CONCLUSIONS
  In this study we found that the characteristics of the largest oscillatory ventilation provide valuable prognostic information in patients with EOV.
authors.affiliation: Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, Virginia 23298-0224, USA. raarena@vcu.edu
authors.forename: Ross
authors.initials: R
authors.lastname: Arena
authors.forename: Jonathan
authors.initials: J
authors.lastname: Myers
authors.forename: Joshua
authors.initials: J
authors.lastname: Abella
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Peberdy
authors.forename: Sherry
authors.initials: S
authors.lastname: Pinkstaff
authors.forename: Daniel
authors.initials: D
authors.lastname: Bensimhon
authors.forename: Paul
authors.initials: P
authors.lastname: Chase
authors.forename: Marco
authors.initials: M
authors.lastname: Guazzi
mesh_terms: D000328:Adult; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010101:Oxygen Consumption / Q000502:physiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012123:Pulmonary Ventilation / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D013990:Tidal Volume / Q000502:physiology