Study on physicochemical properties and in vitro bioactivity of tricalcium silicate-calcium carbonate composite bone cement.
In this article, a novel bone cement composed of tricalcium silicate (Ca(3)SiO(5); C(3)S) and calcium carbonate (CaCO(3)) was prepared with the weight percent of CaCO(3) in the range of 0, 10, 20, 30, and 40%. The initial setting time was dramatically reduced from 90 to 45 min as the content of CaCO(3) increased from 0 to 40%, and the workable paste with a liquid/powder (L/P) ratio of 0.8 ml/g could be injected between 2 and 20 min (nozzle diameter 2.0 mm). The composite cement showed higher mechanical strength (24-27 MPa) than that of the pure Ca(3)SiO(5) paste (14-16 MPa). Furthermore, the composite cement could induce apatite formation and degrade in the phosphate buffered saline. The results indicated that the Ca(3)SiO(5)-CaCO(3) paste had better hydraulic properties than pure Ca(3)SiO(5) paste, and also the composite cement was bioactive and degradable. The novel bone cement could be a potential candidate as a bone substitute.
Huan
Zhiguang
Z
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
Chang
Jiang
J
D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000737:chemistry* / Q000494:pharmacology*; D017610:Calcium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D017640:Silicates / Q000737:chemistry* / Q000494:pharmacology*; D014961:X-Ray Diffraction
D001843:Bone Cements; D017610:Calcium Compounds; D017640:Silicates; C506393:tricalcium silicate; D002119:Calcium Carbonate