Synthesis of novel derivatives of bispodophyllotoxin as potential antineoplastic agents--part XVI.
Podophyllotoxin and related analogs present numerous challenges associated with optimal antitumor activity and severe unpredictable toxicity. In an attempt to find biorational podophyllotoxin-related drug, two moieties of podophyllotoxin have been linked at C4-position by a simple modification of the carbodiimide procedure to provide novel bispodophyllotoxin analogs (4a-4e) and their structural information was extensively characterized by using 1H-NMR, IR, and HRMS.
Liu
Ying-Qian
YQ
School of Pharmacy, Lanzhou University, Lanzhou, PR China. yqliu@lzu.edu.cn
Liu
Ying-Qi
YQ
Tian
Xuan
X
Yang
Liu
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011034:Podophyllotoxin