Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi.
BACKGROUND
This paper describes the antimicrobial activities of 20 lysine-peptoid hybrids against a selection of clinically relevant bacteria and fungi.


METHODS
Minimal inhibitory concentrations were determined against methicillin-susceptible Staphylococcus aureus (ATCC 29213), methicillin-resistant S. aureus (ATCC 33591), vancomycin-intermediate S. aureus (ATCC 700699 MU50), vancomycin-resistant Enterococcus faecium (ATCC 700221), Pseudomonas aeruginosa (ATCC 27853), Salmonella typhimurium (clinical isolate), Klebsiella pneumoniae (clinical isolate), amphotericin-B-resistant C. albicans (ATCC 200955) and Cryptococcus neoformans (clinical isolate).


RESULTS
The lysine-peptoid hybrids proved to be active against all strains tested, except K. pneumoniae. For each susceptible strain, we identified at least 4 lysine-peptoid hybrids showing excellent activity. The most active compounds displayed minimal inhibitory concentrations ranging from < or =1.6 to 6.25 microM.


CONCLUSIONS
This study demonstrates that lysine-peptoid hybrids show activity against drug-resistant pathogens.
Ryge
Trine S
TS
Department of Natural Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.
Frimodt-Møller
Niels
N
Hansen
Paul R
PR
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D004352:Drug Resistance, Microbial / Q000502:physiology; D005658:Fungi / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008239:Lysine / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D034444:Peptoids / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D034444:Peptoids; D008239:Lysine