Chemogenomics and biotechnology.
A robust knowledge of the interactions between small molecules and specific proteins aids the development of new biotechnological tools and the identification of new drug targets, and can lead to specific biological insights. Such knowledge can be obtained through chemogenomic screens. In these screens, each small molecule from a chemical library is applied to each cell type from a library of cells, and the resulting phenotypes are recorded. Chemogenomic screens have recently become very common and will continue to generate large amounts of data. The interpretation of this data will occupy biologists and chemists alike for some time to come. This review discusses methods for the acquisition and interpretation of chemogenomic data, in addition to possible applications of chemogenomics in biotechnology.
Wuster
Arthur
A
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. awuster@mrc-lmb.cam.ac.uk
Madan Babu
M
M
D001709:Biotechnology / Q000379:methods* / Q000639:trends; D049109:Cell Proliferation / Q000187:drug effects; D003627:Data Interpretation, Statistical; D017353:Gene Deletion; D023281:Genomics / Q000379:methods* / Q000639:trends; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology
D029701:Saccharomyces cerevisiae Proteins; D054852:Small Molecule Libraries