Ten-membered lactones from Phomopsis sp., an endophytic fungus of Azadirachta indica.
Four new 10-membered lactones ( 1- 4) and one known one ( 5) were isolated from the broth extract of an endophytic fungus, Phomopsis sp., obtained from the stem of Azadirachta indica. Their structures were assigned by analysis of spectroscopic data, and the structures of 1 and 4 were also confirmed by X-ray analysis. Compounds 1- 5 were tested for antifungal activity against several plant pathogens. Compound 4 demonstrated antifungal activity in the MIC value range 31.25-500 microg/mL.
Wu
Shao-Hua
SH
Yunnan Institute of Microbiology and Laboratory Center, Yunnan University, Kunming 650091, People's Republic of China. shwu123@126.com.
Chen
You-Wei
YW
Shao
Shi-Cheng
SC
Wang
Li-Dong
LD
Li
Zhi-Ying
ZY
Yang
Li-Yuan
LY
Li
Shao-Lan
SL
Huang
Rong
R
D031601:Azadirachta / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure
D007783:Lactones