title: Trans-synaptic plasticity: presynaptic initiation, postsynaptic memory.
abstract: A novel mechanism of persistent facilitation induced by serotonin at Aplysia synapses depends upon rapid postsynaptic protein synthesis and increased responsiveness to glutamate; whereas the memory for this synaptic change is postsynaptic, the initiating signal may be an increase in spontaneous release of glutamate from the presynaptic terminals.
authors.affiliation: Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201-1559, USA.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wan
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Abrams
mesh_terms: D000818:Animals; D001048:Aplysia / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D009046:Motor Neurons / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
chemical_list: D012701:Serotonin; D018698:Glutamic Acid