Bio-inspired polyene cyclization: synthesis of tetracyclic terpenoids promoted by steroidal acetal-SnCl4.
This communication describes a highly efficient intermolecular polyene cyclization method using steroidal acetals as the initiators to synthesize tetracyclic terpenoids; both good yields and good asymmetric induction were obtained.
Zhao
Yu-Jun
YJ
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 1 Nanyang Walk, Block 5 level 3, Singapore639798.
Loh
Teck-Peng
TP
D000080:Acetals / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry*; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*
D000080:Acetals; D013256:Steroids; D013729:Terpenes; D017971:Tin Compounds; C041694:stannic chloride