title: Investigation on the effect of eclipta alba on animal models of learning and memory.
abstract: Short and long term memory loss may result from deteriorating cerebral mechanisms due to varied causes which could have a tremendous impact on the quality of life. Herbs are being constantly explored to resolve cognitive deficits. Eclipta alba (Ea) commonly called as the trailing Eclipta is being examined for its memory enhancing quality as it is traditionally used for this purpose. The shade dried leaves of Eclipta alba was extracted with distilled water. The suspension of Ea containing 100 and 200 mg/kg was administered to rats to evaluate Transfer Latency (TL) on an elevated plus maze. TL was a measure of acquisition and retrieval learning. Mice were placed at the center of open field apparatus to assess spatial habitual learning, observed for 20 minutes for rearing and time spent during rearing using varied doses for 30 minutes, 24 hours and 96 hours and 144 hrs. The results revealed significant improvement of retrieval memory.
authors.affiliation: Department of Pharmacology, Siddaganga College of Pharmacy, Tumkur.
authors.forename: Otilia
authors.initials: O
authors.lastname: Banji
authors.forename: David
authors.initials: D
authors.lastname: Banji
authors.forename: A R
authors.initials: AR
authors.lastname: Annamalai
authors.forename: R
authors.initials: R
authors.lastname: Manavalan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D036601:Eclipta / Q000737:chemistry*; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D023421:Models, Animal; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception / Q000187:drug effects / Q000502:physiology; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014163:Transfer, Psychology / Q000187:drug effects / Q000502:physiology
chemical_list: D010936:Plant Extracts