The berkeleyamides, amides from the acid lake fungus Penicillum rubrum.
We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A-D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds.
Stierle
Andrea A
AA
Department of Chemistry and Geochemistry, Montana Tech of the University of Montana, Butte, MT 59701, USA. astierle@mtech.edu
Stierle
Donald B
DB
Patacini
Brianna
B
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061945:Caspase Inhibitors; D006863:Hydrogen-Ion Concentration; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D009009:Montana; D010407:Penicillium / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015398:Signal Transduction
D000577:Amides; D061945:Caspase Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors