title: Necrotizing pancreatitis: a surgical approach independent of documented infection.
abstract: BACKGROUND
  Strategies for the management of patients with necrotizing pancreatitis remain controversial. While consensus opinion supports operative necrosectomy for the treatment of infected pancreatic necrosis, the timing for surgical intervention is not completely resolved. Further, the indication for the surgical management of sterile pancreatic necrosis is also subject to debate.
  
  
  METHODS
  The objective of this study was to evaluate outcome measures for the surgical management of necrotizing pancreatitis, independent of documented infection. A retrospective review was undertaken between 1994 and 2002 at a single county hospital.
  
  
  RESULTS
  Twenty-one patients with CT-documented necrotizing pancreatitis underwent operative pancreatic necrosectomy with laparostomy within 21 days of initial diagnosis and had an average of three reoperations. Average length of stay (LOS) in the ICU was 36 days and in the hospital 67 days. Ten patients had documented infected necrosis based on initial intra-operative cultures, while I I had sterile necrosis. Overall, 95% (20/21) of the patients had a complication, with an average of three complications per patient. Common complications included ARDS (71%), sepsis (33%), renal failure (24%), and pneumonia (24%). The overall mortality rate was 14% (3/21), with a mean follow-up of 469 days.
  
  
  CONCLUSIONS
  The surgical management of acute necrotizing pancreatitis, independent of documented infection, can be undertaken within 3 weeks of diagnosis with an acceptable morbidity and a low mortality rate. Creation of a laparostomy to enable ready, atraumatic debridement of the retroperitoneum is a safe alternative to standard repeat laparotomies and thus represents a useful adjunct to the surgical management of necrotizing pancreatitis.
authors.affiliation: Department of Surgery, University of California, San Francisco, CA 94143-0104, USA. harrish@surgery.ucsf.edu
authors.forename: H W
authors.initials: HW
authors.lastname: Harris
authors.forename: A
authors.initials: A
authors.lastname: Barcia
authors.forename: M T
authors.initials: MT
authors.lastname: Schell
authors.forename: R F
authors.initials: RF
authors.lastname: Thoeni
authors.forename: W P
authors.initials: WP
authors.lastname: Schecter