Prognostic relevance of the histological subtype of renal cell carcinoma.
OBJECTIVE
According to several studies, when the histological subtype of renal cell carcinoma is established it is possible to attribute a different life expectancy to each patient. We analyzed the prognostic significance of the histological subtype in renal cell carcinoma.


METHODS
The authors retrospectively analyzed the follow-up of 230 patients after radical or conservative renal surgery. The histological characteristics of the different subtypes of tumor were obtained and the disease-free and cancer-specific survival curves for the clear cell, cromophobic, papillary, collecting duct (Bellini) subtypes and those with sarcomatoid differentiation were individualized.


RESULTS
The disease-free and cancer-specific survival rates for clear cell tumors were 76.6% and 68.0% respectively, 71.2% and 82.1% respectively for the cromophobic type, 71.1% and 79.8% respectively for the papillary type, 26.9% and 39.3% respectively for the sarcomatoid type, and 0.0% and 0.0% respectively for the collecting ducts (p < 0.001).


CONCLUSIONS
The histological subtypes of renal tumors can stratify patients into different prognostic groups only when the sarcomatoid differentiation is present.
Dall'Oglio
Marcos F
MF
Division of Urology, School of Medicine, University of Sao Paulo, USP, Sao Paulo, SP, Brazil. marcosdallogliouro@terra.com.br
Antunes
Alberto A
AA
Pompeo
Antonio C
AC
Mosconi
Alcides
A
Leite
Katia R M
KR
Srougi
Miguel
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate