Frequency analysis of the fibrillatory activity from surface ECG lead V1 and intracardiac recordings: implications for mapping of AF.
OBJECTIVE
Fibrillatory waves observed in the surface electrograms may be a direct reflection of the electrophysiologic mechanism of the atrial fibrillation (AF). This study compared the fibrillatory waves in the surface ECG and the individual intracardiac mapping sites in different types of paroxysmal AF.


RESULTS
Thirty patients with paroxysmal AF originating from the pulmonary veins (PVs) or superior vena cava (SVC) were enrolled. Frequency analysis was performed on the intracardiac electrograms recorded from various mapping sites in both atria sequentially with simultaneous surface electrogram recordings. The SVC-AF patients had a trend toward a higher DF in ECG lead V1 when compared with the PV-AF patients (7.35 +/- 2.09 vs. 5.89 +/- 0.79 Hz, P = 0.018). The mean dominant frequency (DF) of the LA mapping sites in the PV-AF patients was higher than that in the SVC-AF patients (7.06 +/- 0.66 vs. 6.13 +/- 0.96 Hz, P = 0.009), whereas the mean DF of the RA mapping sites was similar between the two groups (5.84 +/- 0.80 vs. 6.26 +/- 1.11 Hz, P = NS). The intra-class correlation coefficient (ICC) between the mean DF of the RA sites and V1 was higher (r = 0.21, P = 0.02) when compared with the mean DF of the LA sites (r = -0.007, P > 0.05). Furthermore, the maximal ICC was observed in the anterolateral RA free wall (r = 0.84, P < 0.001) and not the other anatomic sites of the RA and LA.


CONCLUSIONS
The fibrillatory activity observed in ECG lead V1 correlated primarily with the activity of the anterolateral RA free wall and thus may be useful for detecting the AF source if it is close to that area.
Hsu
Nei-Wei
NW
Department of Medicine, Taiwan I-Lan Hospital, I-Lan, Taiwan, Republic of China.
Lin
Yenn-Jiang
YJ
Tai
Ching-Tai
CT
Kao
Tsair
T
Chang
Shih-Lin
SL
Wongcharoen
Wanwarang
W
Lo
Li-Wei
LW
Udyavar
Ameya R
AR
Hu
Yu-Feng
YF
Tso
Han-Wen
HW
Chen
Yi-Jen
YJ
Higa
Satoshi
S
Chen
Shih-Ann
SA
D000328:Adult; D001281:Atrial Fibrillation / Q000503:physiopathology*; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006325:Heart Atria / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D014683:Vena Cava, Superior / Q000503:physiopathology