title: The potential impact of a prophylactic herpes simplex vaccine.
abstract: BACKGROUND
  Herpes simplex virus (HSV) infections have a significant impact on health causing a wide range of diseases. Oral-facial and genital sites are the most common locations of infection and may lead to recurrent painful lesions. HSV infection acquired perinatally may result in severe sequelae or even death despite appropriate therapy. Furthermore, it is becoming increasingly clear that genital HSV infections significantly raise the risk of HIV transmission.
  
  
  OBJECTIVE
  To describe the strategies, impediments, and advancements in the development of vaccines to prevent HSV disease.
  
  
  METHODS
  A review of the literature was performed, limited to prophylactic HSV vaccines and their potential effect on genital herpes, oral-facial disease, and perinatal herpes.
  
  
  CONCLUSIONS
  There are several vaccine strategies under development that show promise for the treatment these diseases.
authors.affiliation: Division of Adolescent & Behavioral Health, Department of Pediatrics, 301 University Blvd., Galveston, TX 77555-1119, USA. rrupp@utmb.edu
authors.forename: Richard
authors.initials: R
authors.lastname: Rupp
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
mesh_terms: D000818:Animals; D006561:Herpes Simplex / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology; D022301:Herpes Simplex Virus Vaccines / Q000008:administration & dosage*; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology
chemical_list: D022301:Herpes Simplex Virus Vaccines