Interactions in free radicals processes between cyclosporine A and sodium fluoride.
The interactions in free radicals processes between cyclosporine A (CsA) and sodium fluoride (NaF) on in vitro model human placental mitochondria were evaluated. The level of malondialdehyde, hydroxyl radical generation and concentration of sulfhydryl groups of protein was measured. The results showed that CsA with NaF did not give any toxicological interactions with NaF in the area of measured parameters.
Srednicka
Dorota
D
Department of Toxicology, Wrocław Medical University 57/59 Traugutta Str., 50-417 Wrocław, Poland.
Długosz
Anna
A
D016572:Cyclosporine / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects; D010920:Placenta / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D005609:Free Radicals; D007166:Immunosuppressive Agents; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; D016572:Cyclosporine; D012969:Sodium Fluoride