title: Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects.
abstract: OBJECTIVE
  To compare the metabolic effects of fructose in healthy male and female subjects.
  
  
  METHODS
  Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young male and female subjects after a 6-day fructose overfeeding.
  
  
  RESULTS
  Fructose overfeeding increased fasting triglyceride concentrations by 71 vs. 16% in male vs. female subjects, respectively (P < 0.05). Endogenous glucose production was increased by 12%, alanine aminotransferase concentration was increased by 38%, and fasting insulin concentrations were increased by 14% after fructose overfeeding in male subjects (all P < 0.05) but were not significantly altered in female subjects. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in male but not in female subjects.
  
  
  CONCLUSIONS
  Short-term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in men, but these effects are markedly blunted in healthy young women.
authors.affiliation: Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland.
authors.forename: Caroline
authors.initials: C
authors.lastname: Couchepin
authors.forename: Kim-Anne
authors.initials: KA
authors.lastname: Lê
authors.forename: Murielle
authors.initials: M
authors.lastname: Bortolotti
authors.forename: Joana Amarante
authors.initials: JA
authors.lastname: da Encarnaçao
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Oboni
authors.forename: Christel
authors.initials: C
authors.lastname: Tran
authors.forename: Philippe
authors.initials: P
authors.lastname: Schneiter
authors.forename: Luc
authors.initials: L
authors.lastname: Tappy
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002149:Energy Intake; D005215:Fasting; D005260:Female; D005632:Fructose / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D012016:Reference Values; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood*
chemical_list: D007328:Insulin; D014280:Triglycerides; D005632:Fructose