title: Independent determinants of second derivative of the finger photoplethysmogram among various cardiovascular risk factors in middle-aged men.
abstract: The second derivative of the finger photoplethysmogram (SDPTG) has been used as a non-invasive examination for arterial stiffness. The present study sought to elucidate independent determinants of the SDPTG among various cardiovascular risk factors in middle-aged Japanese men. The SDPTG was obtained from the cuticle of the left-hand forefinger in 973 male workers (mean age: 44+/-6 years) during a medical checkup at a company. The SDPTG indices (b/a and d/a) were calculated from the height of the wave components. Multiple logistic regression analyses revealed that the independent determinants of an increased b/a (highest quartile of the b/a) were age (odds ratio [OR]: 1.12 per 1-year increase, 95% confidence interval [CI]: 1.09-1.15), hypertension (OR: 1.65, 95% CI: 1.03-2.65), dyslipidemia (OR: 1.51, 95% CI: 1.09-2.09), impaired fasting glucose/diabetes mellitus (OR: 2.43, 95% CI: 1.16-5.07), and a lack of regular exercise (OR: 2.00, 95% CI: 1.29-3.08). Similarly, independent determinants of a decreased d/a (lowest quartile of the d/a) were age (OR: 1.11 per 1-year increase, 95% CI: 1.08-1.14), hypertension (OR: 3.44, 95% CI: 2.20-5.38), and alcohol intake 6 or 7 days per week (OR: 2.70, 95% CI: 1.80-4.06). No independent association was observed between the SDPTG indices and blood leukocyte count or serum C-reactive protein levels. In conclusion, the SDPTG indices reflect arterial properties affected by several cardiovascular risk factors in middle-aged Japanese men. The association between inflammation and the SDPTG should be evaluated in further studies.
authors.affiliation: Environmental Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. otsuka@nms.ac.jp
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Otsuka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kawada
authors.forename: Masao
authors.initials: M
authors.lastname: Katsumata
authors.forename: Chikao
authors.initials: C
authors.lastname: Ibuki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kusama
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D000428:Alcohol Drinking / Q000009:adverse effects / Q000503:physiopathology; D001158:Arteries / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D050171:Dyslipidemias / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D004548:Elasticity; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D016017:Odds Ratio; D017156:Photoplethysmography / Q000379:methods*; D012044:Regression Analysis; D012307:Risk Factors