title: [Effect of aminoguanidine on hemodynamics and nitrogen monoxide in hemorrhagic shock in rabbit].
abstract: OBJECTIVE
  To explore the effect of aminoguanidine (AG) on hemodynamics and nitric oxide (NO) in hemorrhagic shock in rabbit.
  
  
  METHODS
  Shock was produced in twenty rabbits by femoral artery blood letting, and they were randomly divided into two groups with treatment with saline (control group) or AG (each n=10). Pclab system and nitric acid reductase methods were performed to detect hemodynamics parameters and NO levels at preshock, postshock (30 minutes and 150 minutes) and 30 minutes and 180 minutes after resuscitation respectively.
  
  
  RESULTS
  No significant differences were observed in hemodynamics parameters and NO levels between the two groups before resuscitation. Whereas after resuscitation, hemodynamics parameters such as systolic arterial pressure (SAP), heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP) and the max and minimum first derivative of left ventricular pressure (+/-dp/dt max) were all improved greatly in the two groups. AG decreased serum NO level significantly, while saline did not have such effect, suggesting that AG had a longer and more efficient effect against hemorrhagic shock (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  AG can improve hemodynamics parameters and decrease NO level in hemorrhagic shock in rabbit.
authors.affiliation: Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, Hunan, China.
authors.forename: Zhi-ping
authors.initials: ZP
authors.lastname: Gao
authors.forename: Duan-fang
authors.initials: DF
authors.lastname: Liao
authors.forename: Bo-ping
authors.initials: BP
authors.lastname: Li
authors.forename: De-ping
authors.initials: DP
authors.lastname: Liu
authors.forename: Jian-zhi
authors.initials: JZ
authors.lastname: Liu
authors.forename: Chao-ke
authors.initials: CK
authors.lastname: Tang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D011817:Rabbits; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000503:physiopathology* / Q000628:therapy
chemical_list: D006146:Guanidines; D009569:Nitric Oxide; C004479:pimagedine