title: [Distribution and antifungal susceptibility of Candida clinical isolations coming from six health care centers in the metropolitan area of Caracas, Venezuela (years 2003-2005)].
abstract: The aim of this study was to investigate the frequency and antifungal susceptibility of Candida clinical isolations coming from patients with candidiasis in six health care centers of Caracas, Venezuela metropolitan area. The laboratory reports were retrospectively revised from January 2003 through August 2005. The isolated yeasts identification was carried out by conventional methods and antifungal susceptibility was evaluated by ATB-fungus (bioMérieux, France) and Etest (AB Biodisk, Solna, Sweden). One thousand nine hundred seventy seven (1.977) yeasts were studied and their susceptibility testing were carried out only in 1,414 of them. C. albicans was the most isolated yeast (46.7%) and none-albicans Candida-species represented more than half of the isolations (53.4%). All the isolated yeasts evaluated presented CMIs<1 microg/ml to anfotericina B and showed variable susceptibility percentages to fluconazole (91.5%), itraconazole (80%) and voriconazole (98.6%).
authors.affiliation: Departamento de Micología, Instituto Nacional de Higiene Rafael Rangel, Ciudad Universitaria, Los Chaguaramos, Caracas, Venezuela. mdolande@inhrr.gov.ve
authors.forename: Maribel E
authors.initials: ME
authors.lastname: Dolande Franco
authors.forename: Vera
authors.initials: V
authors.lastname: Reviákina
authors.forename: María Mercedes
authors.initials: MM
authors.lastname: Panizo
authors.forename: Carolina
authors.initials: C
authors.lastname: Macero
authors.forename: Xiomara
authors.initials: X
authors.lastname: Moreno
authors.forename: Alberto
authors.initials: A
authors.lastname: Calvo
authors.forename: Sofía
authors.initials: S
authors.lastname: Selgrad
authors.forename: Juana
authors.initials: J
authors.lastname: Papatzikos
authors.forename: Vivian
authors.initials: V
authors.lastname: Vergara
authors.forename: María José
authors.initials: MJ
authors.lastname: Mendoza
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001826:Body Fluids / Q000382:microbiology; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D009928:Organ Specificity; D012189:Retrospective Studies; D013045:Species Specificity; D014687:Venezuela / Q000453:epidemiology
chemical_list: D000935:Antifungal Agents