title: [Clinical problems and prospects in laboratory chemical analysis].
abstract: The first subject of clinical problems is about uncertainty in measurement, but is now going be clarified by the standardization of reference measurement procedure and reference material. On the other hand, physiological uncertainty in samples is unable to be solved. So the establishment of evidence based diagnostic values is important in company with reference value, especially in the field of health examination. The life expectancy of the Japanese population is one of longest in the world. So the preventive medicine of lifestyle-related disease is important to perform an extensive research like as disease preventive biomarkers. Furthermore, we expect the progression of examinations in the pathophysiological diagnosis. I present the paper of development for the diagnostic method of dihydropyrimidine dehydrogenase-deficient as an example.
authors.affiliation: Graduate School of Nursing, Miyagi University, Kurokawa-gun, Miyagi.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawamura
mesh_terms: D002624:Chemistry, Clinical; D019963:Clinical Chemistry Tests; D019411:Clinical Laboratory Techniques; D054067:Dihydropyrimidine Dehydrogenase Deficiency / Q000175:diagnosis; D006801:Humans; D011315:Preventive Medicine