Utility of targeted glucocorticoids in cancer therapy.
Glucocorticoids can inhibit solid tumor growth via downregulation of tumor-associated inflammation/angiogenesis. In this minireview we describe the possible mechanisms of glucocorticoid action in tumor growth inhibition. We also present an overview of the current status of tumor-targeted glucocorticoid delivery. It appears that long-circulating liposomes are the only targeting system currently being explored for this purpose.
Banciu
Manuela
M
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Schiffelers
Raymond M
RM
Metselaar
Josbert M
JM
Storm
Gert
G
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D016503:Drug Delivery Systems; D023281:Genomics; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D009389:Neovascularization, Pathologic; D014158:Transcription, Genetic
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D008081:Liposomes