title: Anti-oligosaccharide antibodies as tools for studying sulfated sialoglycoconjugate ligands for siglecs and selectins.
abstract: Several sulfated sialoglycoconjugates have recently been shown to serve as ligands for selectins and siglecs. For instance, alpha2-->3 sialylated 6-sulfo-Lewis x was found to serve as a ligand for selectins on skin-homing helper memory T cells, and alpha2-->6 sialylated 6-sulfo-LacNAc to be a preferred ligand for CD22/siglec-2 on human naïve B cells. Monoclonal antibodies specific to sulfated sialoglycoconjugates are effective tools to dissect these ligands on minor subsets of human leukocytes.
authors.affiliation: Department of Molecular Pathology, Research Institute, Aichi Cancer Center, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan. rkannagi@aichi-cc.jp
authors.forename: Reiji
authors.initials: R
authors.lastname: Kannagi
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Ohmori
authors.forename: Naoko
authors.initials: N
authors.lastname: Kimura
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001671:Biochemistry / Q000379:methods*; D006001:Glycoconjugates / Q000276:immunology*; D006801:Humans; D037102:Lectins / Q000276:immunology*; D008024:Ligands; D019158:N-Acetylneuraminic Acid / Q000276:immunology; D009844:Oligosaccharides / Q000276:immunology*; D019087:Selectins / Q000276:immunology*; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D013431:Sulfates / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D006001:Glycoconjugates; D037102:Lectins; D008024:Ligands; D009844:Oligosaccharides; D019087:Selectins; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D013431:Sulfates; D019158:N-Acetylneuraminic Acid