title: Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor.
abstract: Bacterial sigma (sigma) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative sigma factor sigma(54) confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the sigma(54) factor makes with the bacterial transcription machinery.
authors.affiliation: Department of Microbiology, Division of Investigative Sciences, Faculty of Medicine and Centre for Molecular Microbiology and Infection, Imperial College London, SW7 2AZ, UK. s.r.wig@imperial.ac.uk
authors.forename: Sivaramesh
authors.initials: S
authors.lastname: Wigneshweraraj
authors.forename: Daniel
authors.initials: D
authors.lastname: Bose
authors.forename: Patricia C
authors.initials: PC
authors.lastname: Burrows
authors.forename: Nicolas
authors.initials: N
authors.lastname: Joly
authors.forename: Jörg
authors.initials: J
authors.lastname: Schumacher
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rappas
authors.forename: Tillmann
authors.initials: T
authors.lastname: Pape
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
authors.forename: Peter
authors.initials: P
authors.lastname: Stockley
authors.forename: Konstantin
authors.initials: K
authors.lastname: Severinov
authors.forename: Martin
authors.initials: M
authors.lastname: Buck
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry* / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D051877:RNA Polymerase Sigma 54 / Q000737:chemistry* / Q000378:metabolism; D012329:RNA, Bacterial / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012329:RNA, Bacterial; D012321:DNA-Directed RNA Polymerases; D051877:RNA Polymerase Sigma 54