title: Onycholysis associated with capecitabine in patients with breast cancer.
abstract: BACKGROUND
  Onycholysis, which is separation of the nail plate from the nail bed at its distal and lateral attachments, can cause pain and impair function and is a well-known side effect of traditional chemotherapeutic agents.
  
  
  OBJECTIVE
  We present two cases of onycholysis associated with capecitabine in women with advanced breast cancer, who were initially referred for evaluation of onychomycosis and review the literature on capecitabine.
  
  
  CONCLUSIONS
  Owing to the increased frequency of use of capecitabine for different cancers, physicians should be aware of this side effect.
authors.affiliation: Division of Dermatology, University of Ottawa, ON. hogelingm@yahoo.ca
authors.forename: Marcia
authors.initials: M
authors.lastname: Hogeling
authors.forename: Jessica
authors.initials: J
authors.lastname: Howard
authors.forename: Nordau
authors.initials: N
authors.lastname: Kanigsberg
authors.forename: Harvey
authors.initials: H
authors.lastname: Finkelstein
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects; D008875:Middle Aged; D009262:Nails; D054039:Onycholysis / Q000139:chemically induced*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil