Hollow silica nanocontainers as drug delivery vehicles.
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
Yang
Jaemoon
J
Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-752, Korea.
Lee
Jaewon
J
Kang
Jinyoung
J
Lee
Kwangyeol
K
Suh
Jin-Suck
JS
Yoon
Ho-Geun
HG
Huh
Yong-Min
YM
Haam
Seungjoo
S
D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005290:Ferric Compounds; D053769:Nanocapsules / Q000737:chemistry*; D012822:Silicon Dioxide; D013329:Structure-Activity Relationship
D005290:Ferric Compounds; D053769:Nanocapsules; C001215:ferrite; D012822:Silicon Dioxide; D004317:Doxorubicin