title: Glycation associated skin autofluorescence and skin elasticity are related to chronological age and body mass index of healthy subjects.
abstract: Glycation is the non-enzymatic reaction between reducing sugars and proteins that leads to the formation of advanced glycation end products (AGEs). In vivo skin autofluorescence (lambda(ex)/lambda(em)=370/440 nm) was used as a non-invasive clinical tool to study skin AGE accumulation in healthy panellists. Using multiple linear regression analysis, it was shown that for panellists below the age of 40, glycation associated in vivo skin fluorescence intensity increased as a function of chronological age and body mass index (BMI). Above the age of 40, the fluorescence was associated to age but not to BMI, suggesting that the effect of age became dominant over BMI. Since the accumulation of AGEs is expected to affect the biomechanical properties of the skin, in vivo skin elasticity data were gathered on a second panel. It was found that skin elasticity depended on age and BMI in a similar fashion as to what we observed for the skin fluorescence data. It is hypothesised that skin AGE accumulation contributes to the loss of skin elasticity in aged and/or overweight people.
authors.affiliation: Estée Lauder Companies, Biological Research Department Europe, Nijverheidsstraat 15, 2260 Oevel, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Corstjens
authors.affiliation: Estée Lauder Companies, Melville, NY, USA.
authors.forename: D
authors.initials: D
authors.lastname: Dicanio
authors.affiliation: Estée Lauder Companies, Melville, NY, USA.
authors.forename: N
authors.initials: N
authors.lastname: Muizzuddin
authors.affiliation: Estée Lauder Companies, Biological Research Department Europe, Nijverheidsstraat 15, 2260 Oevel, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Neven
authors.affiliation: Estée Lauder Companies, Melville, NY, USA.
authors.forename: R
authors.initials: R
authors.lastname: Sparacio
authors.affiliation: Estée Lauder Companies, Biological Research Department Europe, Nijverheidsstraat 15, 2260 Oevel, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Declercq
authors.affiliation: Estée Lauder Companies, Melville, NY, USA.
authors.forename: D
authors.initials: D
authors.lastname: Maes
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D015992:Body Mass Index; D004548:Elasticity; D005260:Female; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000378:metabolism / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000378:metabolism; D015595:Skin Aging / Q000502:physiology; D012879:Skin Physiological Phenomena; D012880:Skin Pigmentation / Q000502:physiology; D013050:Spectrometry, Fluorescence
chemical_list: D017127:Glycation End Products, Advanced