title: Total agenesis of the corpus callosum in a patient with childhood-onset schizophrenia.
abstract: The hypothesis that schizophrenia involves aberrant inter-hemispheric communication has a long pedigree, however its precise role remains unclear. We therefore report the case of a total agenesis of the corpus callosum in a 21-year-old man with childhood-onset schizophrenia. The presence of schizophrenia with very early onset on absence of corpus callosum offers an opportunity to examine neurodevelopmental model and theories regarding to interhemispheric communication in the pathogenesis of psychosis.
authors.affiliation: Department of Neurology, Psychiatry and Psychological Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. jhallak@fmrp.usp.br
authors.forename: Jaime Eduardo Cecilio
authors.initials: JE
authors.lastname: Hallak
authors.forename: José Alexandre de Sousa
authors.initials: JA
authors.lastname: Crippa
authors.forename: Joel Porfírio
authors.initials: JP
authors.lastname: Pinto
authors.forename: João Paulo
authors.initials: JP
authors.lastname: Machado de Sousa
authors.forename: Clarissa
authors.initials: C
authors.lastname: Trzesniak
authors.forename: Serdar Murat
authors.initials: SM
authors.lastname: Dursun
authors.forename: Phillip
authors.initials: P
authors.lastname: McGuire
authors.forename: John Francis William
authors.initials: JF
authors.lastname: Deakin
authors.forename: Antonio Waldo
authors.initials: AW
authors.lastname: Zuardi
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012561:Schizophrenia, Childhood / Q000209:etiology* / Q000473:pathology