title: Separation and identification of botanical insecticide 7-hydroxycoumarin and its biological activity against Aphis craccivora and Culex pipiens pallens.
abstract: The root powder of Stellera chamaejasme was extracted with chloroform. The crude extract obtained was chromatographed with silica gel columns many times. One pure natural product was obtained. It was identified as 7-hydroxycoumarin. Laboratory bioassay showed that it had a good insecticidal activity against Aphis craccivora and Culex pipiens pallens. Its median lethal concentrations (LC50) (24 h after treatment) were 19.56 and 0.435 mg L(-1), respectively. The results of regressive and correlative analysis demonstrated that the correlations were very significant between concentration and efficacy. The corresponding correlative coefficients were 0.9686 and 0.9712, respectively. This is the first report of the insecticidal activity of 7-hydroxycoumarin. It may represent a new class of insecticides.
authors.affiliation: Key Laboratory for Biological Resources and Ecological Environment of Education Ministry (China), College of Life Science, Sichuan University, Chengdu 610064, People's Republic of China.
authors.forename: Tang
authors.initials: T
authors.lastname: Xiaorong
authors.forename: Hou
authors.initials: H
authors.lastname: Taiping
mesh_terms: D000818:Animals; D001042:Aphids / Q000187:drug effects*; D003465:Culex / Q000187:drug effects*; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D014468:Umbelliferones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D014468:Umbelliferones; C031477:7-hydroxycoumarin