Toward the Total Synthesis of Scleritodermin A: Preparation of the C(1)-N(15) Fragment.
The synthesis of the C(1)-N(15) fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the alpha-keto amide linkage by the use of a highly activated alpha, beta-ketonitrile.
Sellanes
Diver
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Cátedra de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, UDELAR, Av. General Flores 2124, C. C. 1157, Montevideo, Uruguay.
Manta
Eduardo
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Serra
Gloria
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