title: Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women.
abstract: Although circulating glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a minor high-density lipoprotein-associated protein, is elevated in patients with insulin resistance or high triglycerides, no information is available on the effect of weight loss or changes in insulin sensitivity on circulating GPI-PLD levels. The objective of the study was to determine the effect of weight loss and changes in insulin sensitivity on plasma GPI-PLD levels. Forty-two nondiabetic obese women were included in the study, which involved a 3-month dietary intervention randomizing patients to a low-fat or a low-carbohydrate diet. The study's main outcome measures were plasma GPI-PLD levels and insulin sensitivity as estimated by the homeostasis model assessment. The very low carbohydrate diet group lost more weight after 3 months (-7.6 +/- 3.2 vs -4.2 +/- 3.5 kg, P < .01), although the decrease in insulin resistance was similar between groups. Weight loss with either diet did not alter plasma GPI-PLD levels. However, baseline GPI-PLD levels correlated with the change in insulin sensitivity in response to the low-fat diet, whereas baseline insulin sensitivity correlated with the change in insulin sensitivity in response to the low-carbohydrate diet. Plasma GPI-PLD may serve as a clinical tool to determine the effect of a low-fat diet on insulin sensitivity.
authors.affiliation: Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
authors.forename: Dona L
authors.initials: DL
authors.lastname: Gray
authors.forename: Kevin D
authors.initials: KD
authors.lastname: O'Brien
authors.forename: David A
authors.initials: DA
authors.lastname: D'Alessio
authors.forename: Bonnie J
authors.initials: BJ
authors.lastname: Brehm
authors.forename: Mark A
authors.initials: MA
authors.lastname: Deeg
mesh_terms: D000328:Adult; D050528:Diet, Carbohydrate-Restricted; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D010739:Phospholipase D / Q000097:blood*; D015431:Weight Loss
chemical_list: D010739:Phospholipase D; C065017:glycoprotein phospholipase D