title: [The characteristics of left ventricular myocardial remodeling in patients with chronic renal disease, and the effects of spironolactone therapy].
abstract: The work reflects modern concepts of the pathogenesis of myocardial and vascular remodelling in a chronic renal disease. Types of changes in left ventricular geometry and the condition of the diastolic function in patients at pre-dialysis stage of a chronic renal disease and patients on program hemodialysis. Dynamic changes in left ventricular parameters under the influence of therapy with spironolactone, an aldosterone receptor blocker, are described. The use of spironolactone in a dose of 25 mg per day is shown to regress myocardial hypertrophy in anuric patients on hemodialysis.
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Karabaeva
authors.forename: A M
authors.initials: AM
authors.lastname: Esaian
authors.forename: I G
authors.initials: IG
authors.lastname: Kaiukov
mesh_terms: D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D006435:Renal Dialysis; D013148:Spironolactone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects / Q000502:physiology*
chemical_list: D004232:Diuretics; D013148:Spironolactone