Evidence that AphB, essential for the virulence of Vibrio vulnificus, is a global regulator.
The Vibrio vulnificus aphB mutant was significantly less virulent than the wild type and was impaired in motility and adherence to host cells. Microarray analysis revealed that AphB of V. vulnificus (AphB(Vv)) influences the expression of over 10% of the V. vulnificus genome. The combined results indicated that AphB(Vv) is a global regulator contributing to the pathogenesis of V. vulnificus.
Jeong
Hee Gon
HG
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea.
Choi
Sang Ho
SH
D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D005809:Genes, Regulator; D046228:Microarray Analysis; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014735:Vibrio Infections; D041261:Vibrio vulnificus / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*
C120327:AphB protein, Vibrio cholerae; D001426:Bacterial Proteins; D015534:Trans-Activators