title: Do we need molecular tomography of a cell and how can it be achieved?
abstract: 1. The spatial relationship between intracellular molecules and their local concentrations are two critical parameters required for a better understanding of protein-protein interactions in the cell. 2. Determination of the local concentration of proteins in individual cells using more sophisticated techniques and determination of the spatial relationship between a molecular platform and its partners is essential for allow us to obtain more convincing and concrete scientific conclusions. 3. As a reasonable goal, development of molecular tomography of the cell is proposed.
authors.affiliation: Institute of Neuroscience, Second Military Medical University, Shanghai, China. yzchen0928@yahoo.com
authors.forename: Yi-Zhang
authors.initials: YZ
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
mesh_terms: D002477:Cells / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure; D034521:Nuclear Matrix-Associated Proteins / Q000648:ultrastructure; D011485:Protein Binding; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods*
chemical_list: D034521:Nuclear Matrix-Associated Proteins