title: Occurrence of a germinoma 22 years after resection of a mature cerebral teratoma.
abstract: We present the rare case of a 31-year-old man who developed a germinoma 22 years after resection of a mature teratoma of the pineal region. The initial stereotactic biopsy showed a granulomatous inflammation, but no malignant cells. The correct diagnosis could only be confirmed in a second cerebral biopsy, allowing for proper treatment with radiation therapy. The need to consider metachronous germinoma in this setting is discussed.
authors.affiliation: Department of Neurology, Neurocenter, University of Freiburg, Freiburg, Germany. wibke.janzarik@uniklinik-freiburg.de
authors.forename: Wibke G
authors.initials: WG
authors.lastname: Janzarik
authors.forename: Klaus
authors.initials: K
authors.lastname: Müller
authors.forename: Michael
authors.initials: M
authors.lastname: Lübbert
authors.forename: Joachim
authors.initials: J
authors.lastname: Spreer
authors.forename: Michael
authors.initials: M
authors.lastname: Trippel
authors.forename: Inge
authors.initials: I
authors.lastname: Uhlig
authors.forename: Cornelius
authors.initials: C
authors.lastname: Weiller
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rauer
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery*; D018237:Germinoma / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology; D013724:Teratoma / Q000601:surgery*