Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3.
Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.
Hinrichsen
Kerstin
K
University Hospital Schleswig-Holstein, Department of Dermatology, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany.
Podschun
Rainer
R
Schubert
Sabine
S
Schröder
Jens M
JM
Harder
Jürgen
J
Proksch
Ehrhardt
E
D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002478:Cells, Cultured; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D013211:Staphylococcus aureus / Q000187:drug effects; D016211:Transforming Growth Factor alpha / Q000494:pharmacology; D023083:beta-Defensins / Q000235:genetics / Q000494:pharmacology*
D000890:Anti-Infective Agents; C422950:DEFB103A protein, human; D012333:RNA, Messenger; D016211:Transforming Growth Factor alpha; D023083:beta-Defensins; D007371:Interferon-gamma