title: Body mass index status is effective in identifying metabolic syndrome components and insulin resistance in Pacific Island teenagers living in New Zealand.
abstract: Although adults of Pacific ethnicity living in New Zealand have more than double the prevalence of diabetes and cardiovascular disease than the general population, little is known regarding the presence of risk factors for these disorders among young Pacific Islanders. The study aim was to examine relationships between body composition, glucose and lipid metabolism, and components of the metabolic syndrome (MS) in a community sample of Pacific Island (PI) teenagers living in Dunedin. Anthropometry, body composition (dual-energy x-ray absorptiometry), glucose and lipid metabolism, insulin resistance (homeostasis model assessment [HOMA2], McAuley index), and components of MS were assessed in 80 PI teenagers (aged 15-18 years). Results showed that 6 participants had full MS, 2 had high fasting blood glucose values (>7.0 mmol/L), 55 had high adiposity, and 21 had insulin resistance. Assessment of the components of MS by body mass index (BMI) status showed that obese participants (n = 29) had a high prevalence (86.2% had one or more component), whereas only 10.5% of those with healthy BMI status (n = 19) had any MS component. Elevated fat mass had substantial effects on fasting insulin values, HOMA2, and the McAuley index because in data adjusted for age, sex, and lean mass, a 10% greater fat mass was associated with a 4.7% increase in fasting insulin, a 5.3% rise in HOMA2, and a 2.3% decrease in the McAuley index. Our results suggest that the antecedents of cardiovascular disease and type 2 diabetes mellitus occur frequently in young Pacific Islanders having high adiposity. We conclude that community studies of PI adolescents should focus on assessing risk factors whenever BMI values are high.
authors.affiliation: Department of Medical and Surgical Sciences, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Grant
authors.forename: Finau K
authors.initials: FK
authors.lastname: Taungapeau
authors.forename: Kirsten A
authors.initials: KA
authors.lastname: McAuley
authors.forename: Rachael W
authors.initials: RW
authors.lastname: Taylor
authors.forename: Sheila M
authors.initials: SM
authors.lastname: Williams
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Waldron
authors.forename: Ashley W
authors.initials: AW
authors.lastname: Duncan
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Harper
authors.forename: Ailsa
authors.initials: A
authors.lastname: Goulding
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D009520:New Zealand; D010139:Pacific Islands / Q000208:ethnology
chemical_list: D007328:Insulin