Intramolecular azide-alkyne cycloaddition for the fast assembly of structurally diverse, tricyclic 1,2,3-triazoles.
The synthesis of novel tricyclic 1,2,3-triazoles starting from cyclic epoxides via the sequential azidolysis, propargylation and 1,3-dipolar cycloaddition is described. Derivatization by N-arylation reaction and the synthesis of enantiomerically pure compounds is also reported. Some of these compounds exhibit significant affinity for the sigma-1 receptor.
Oliva
Ana I
AI
Institute of Chemical Research of Catalonia (ICIQ), Avenida Països Catalans 16, Tarragona, Spain.
Christmann
Ute
U
Font
Daniel
D
Cuevas
Félix
F
Ballester
Pablo
P
Buschmann
Helmut
H
Torrens
Antoni
A
Yenes
Susana
S
Pericàs
Miquel A
MA