title: Medically controlled glaucoma patients show greater increase in intraocular pressure than surgically controlled patients with the water drinking test.
abstract: OBJECTIVE
  To evaluate whether patients who have undergone trabeculectomy with mitomycin C have a different intraocular pressure (IOP) response profile after the water drinking test (WDT) from that of patients who are medically managed with a similar baseline IOP and level of visual field (VF) damage.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Thirty glaucoma patients with IOP controlled by trabeculectomy and 30 with medically treated glaucoma matched for level of VF damage and IOP at baseline (7-14 mmHg).
  
  
  METHODS
  All patients underwent the WDT, which involved drinking 1000 ml of water in 15 minutes.
  
  
  METHODS
  The IOP was measured before the WDT and subsequently at 15-minute intervals for 1 hour. The peak IOP with the WDT was compared between both groups using Tukey post hoc multiple comparison and paired t tests.
  
  
  RESULTS
  Baseline IOPs were 10.4+/-2.3 mmHg in surgically treated and 11.1+/-1.8 mmHg (P = 0.07) in medically treated eyes. After the WDT, mean IOPs in the surgically and medically treated groups were 10.7+/-2.3 mmHg and 14.6+/-2.2 mmHg. Mean maximum IOPs were 11.7+/-2.6 mmHg and 17.3+/-2.7 mmHg in the surgically and medically treated groups, respectively (P<0.0001), increases of 12.5% and 56%. Ranges of IOP during the WDT were 2.2+/-1.3 mmHg and 5.6+/-1.9 mmHg in the surgically and medically treated patients (P<0.0001).
  
  
  CONCLUSIONS
  Patients with advanced glaucoma who are medically controlled show greater IOP elevation and peak IOP after the WDT than eyes that have undergone trabeculectomy.
authors.affiliation: Department of Ophthalmology, University of Auckland, Auckland, New Zealand. h.daneshmeyer@auckland.ac.nz
authors.forename: Helen V
authors.initials: HV
authors.lastname: Danesh-Meyer
authors.forename: Taras
authors.initials: T
authors.lastname: Papchenko
authors.forename: Yu-whee
authors.initials: YW
authors.lastname: Tan
authors.forename: Greg D
authors.initials: GD
authors.lastname: Gamble
mesh_terms: D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003941:Diagnostic Techniques, Ophthalmological; D004326:Drinking; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D011446:Prospective Studies; D014130:Trabeculectomy / Q000379:methods*; D014786:Vision Disorders / Q000503:physiopathology / Q000628:therapy; D014794:Visual Fields; D014867:Water
chemical_list: D000477:Alkylating Agents; D000959:Antihypertensive Agents; D014867:Water; D016685:Mitomycin