Perineal use of talc and risk of ovarian cancer.
Ovarian cancer is one of the most common gynaecological neoplasms, especially in industrialised countries. The aetiology of the disease is not well understood, except that inherited mutations in the breast cancer genes BRCA-1 and BRCA-2 account for up to 10% of all cases, and child-bearing, oral contraceptive use and breast-feeding reduce the risk. Some environmental exposures, notably talc and asbestos, have been suspected as ovarian carcinogens.
Langseth
H
H
The Cancer Registry of Norway, Institute of populationbased, Cancer Research, Oslo, Norway.
Hankinson
S E
SE
Siemiatycki
J
J
Weiderpass
E
E
D001505:Beauty Culture; D016022:Case-Control Studies; D003358:Cosmetics / Q000009:adverse effects; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology*; D010502:Perineum; D013627:Talc / Q000009:adverse effects*
D003358:Cosmetics; D013627:Talc