Epstein-Barr virus-associated epithelial and mesenchymal neoplasms.
Epstein-Barr virus (EBV) is a ubiquitous human pathogen that usually maintains a harmonious relationship with its host. Rarely, this host-virus balance is perturbed, causing a diverse group of malignancies in both immunocompetent and immunosuppressed patients. In addition to its role in hematologic malignancies (Burkitt lymphoma, subsets of Hodgkin and T-cell lymphomas, posttransplant lymphomas), EBV has been implicated in both epithelial (undifferentiated nasopharyngeal carcinoma, a subset of gastric adenocarcinomas) and mesenchymal (EBV-associated smooth muscle tumor, inflammatory pseudotumor-like follicular dendritic cell tumor) neoplasms. This review will focus on EBV-associated epithelial and mesenchymal neoplasms.
Deyrup
Andrea T
AT
Department of Pathology, Emory University Atlanta, GA 30322, USA. adeyrup@emory.edu
D002277:Carcinoma / Q000473:pathology* / Q000821:virology*; D004847:Epithelial Cells / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000473:pathology* / Q000821:virology*