title: Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide.
abstract: Current chemotherapy treatment of solid tumors is limited due to a lack of specific delivery of the drugs to the tumor, leading to systemic toxicity. Therefore, it is necessary to develop targeted cancer therapies and tumor-targeted drug carriers. The authors review the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutics. The authors searched Medline for articles concerning the application of ELP as a drug delivery vector for small molecule drugs and therapeutic peptides. ELP has been demonstrated to be a promising thermally targeted carrier. Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics.
authors.affiliation: University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA. draucher@biochem.umsmed.edu
authors.forename: Drazen
authors.initials: D
authors.lastname: Raucher
authors.forename: Iqbal
authors.initials: I
authors.lastname: Massodi
authors.forename: Gene L
authors.initials: GL
authors.lastname: Bidwell
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004549:Elastin / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D004549:Elastin