title: A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.
abstract: Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by chi(2) test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.
authors.affiliation: Immunolgy Center, Section of Nutrition, Immunity, and Ageing, Research Department INRCA, Ancona, Italy. rogiacconi@libero.it
authors.forename: Robertina
authors.initials: R
authors.lastname: Giacconi
authors.forename: Elisa
authors.initials: E
authors.lastname: Muti
authors.forename: Marco
authors.initials: M
authors.lastname: Malavolta
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cardelli
authors.forename: Sara
authors.initials: S
authors.lastname: Pierpaoli
authors.forename: Catia
authors.initials: C
authors.lastname: Cipriano
authors.forename: Laura
authors.initials: L
authors.lastname: Costarelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Tesei
authors.forename: Vittorio
authors.initials: V
authors.lastname: Saba
authors.forename: Eugenio
authors.initials: E
authors.lastname: Mocchegiani
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics*; D000596:Amino Acids / Q000235:genetics*; D002340:Carotid Artery Diseases / Q000235:genetics*; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D000596:Amino Acids; D027682:Cation Transport Proteins; D003062:Codon; C498424:SLC39A2 protein, human