[Relationship between fibrinogen level and pathogenesis of sudden sensorineural hearing loss].
OBJECTIVE
To study the relationship between fibrinogen level and pathogenesis of sudden sensorineural hearing loss(SSHI.).


METHODS
Fifty patients (55 ears) with SSHL within 7 days of the onset were studied: a control group was consist of 50 normal-hearing people who were individually matched on a pairwise basis according to the same gender and age. Both the patients and the normal people were tested for the parameters of hemorheology, blood biochemistry, whole blood cell count and clotting function.


RESULTS
Fibrinogen level and plasma viscosity in patients with SSHL were significantly higher than that in control subjects. Prothrombin time and activated partial thromboplastic time were significantly less in the patients group than that in the control group (P < 0.05). There were statistical difference. The parameters of blood biochemistry, whole blood cell count and platelet adhesion test of two groups had no significant difference (P > 0.05).


CONCLUSIONS
Elevated plasma fibrinogen may be a major pathogenesis of SSHL. An increase in plasma fibrinogen level may lead to elevated plasma viscosity. All these may promote a prothrombin or hypercoagulable state and impair blood perfusion of cochlea.
Lu
Liangjun
L
Department of Otolaryngology-Head and Neck Surgery, Haian Hospital of Nantong University, Haian, 226600, China. entllj@haianedu.net
hong
Zhisheng
Z
Yu
Yinkun
Y
Du
Xiaodong
X
Gu
Ping
P
Wu
Jun
J
Wang
Xu
X
Zhou
Shufang
S
Gu
Xiaochun
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000209:etiology; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000209:etiology; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D005340:Fibrinogen