Modeling of asthma, COPD and cystic fibrosis in sheep.
Sheep naturally allergic to Ascaris suum antigen have been used to study the pathophysiology of asthma and more recently allergic rhinitis, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The utility of the model as it relates to the study of these diseases is discussed.
Abraham
William M
WM
Department of Research, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA. abraham@msmc.com
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004195:Disease Models, Animal; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*