title: Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively.
abstract: Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD diagnosis. Diffusion Tensor MRI (DT-MRI) is a quantitative technique that allows microscopic tissue abnormalities to be non-invasively assessed in vivo. A single case of clinically suspected CBD with symmetric diffuse brain atrophy on conventional-MRI scans was studied using DT-MRI by voxel-wise comparison with eight healthy subjects. The lateralized distribution of DT-MRI abnormalities was consistent with clinical features providing a substantial support to the diagnosis.
authors.affiliation: Neuroimaging Laboratory, Santa Lucia Foundation, IRCCS, Via Ardeatina 306, 00179 Rome, Italy. m.bozzali@hsantalucia.it
authors.forename: M
authors.initials: M
authors.lastname: Bozzali
authors.forename: M
authors.initials: M
authors.lastname: Cercignani
authors.forename: F
authors.initials: F
authors.lastname: Baglio
authors.forename: G
authors.initials: G
authors.lastname: Scotti
authors.forename: E
authors.initials: E
authors.lastname: Farina
authors.forename: L
authors.initials: L
authors.lastname: Pugnetti
authors.forename: J
authors.initials: J
authors.lastname: Ashburner
authors.forename: R
authors.initials: R
authors.lastname: Nemni
authors.forename: A
authors.initials: A
authors.lastname: Falini
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods