What options does the supine-standing-supine test offer to patients with hypertension? Demonstrations of examples.
OBJECTIVE
The purpose of the study was to demonstrate autonomic nervous system (ANS) changes associated with treatment in hypertensive patients and utilization of these measurements in practice.


METHODS
Hypertensive patients were examined before the start of treatment and after blood pressure compensation. The telemetric system VarCor PF 5 was used for non-invasive heart rate registration and automatic evaluation of heart rate variability (HRV) parameters. The supine-standing-supine test with ortho-clinostatic loading in standard conditions was used for HRV evaluation.


RESULTS
The influence of antihypertensive therapy on ANS was demonstrated in two cases. The first was a case of a responder to therapy and the second case was example of a non-responder to monotherapy regarding more therapeutic steps for blood pressure control. Different modes of results presentation are demonstrated: 3D graph, numeric form of standard parameters of HRV, computer interpretation of results by means of complex parameters and indices in numeric, graphic and verbal form with functional age calculation, cross graph of vagal activity index versus sympatho-vagal balance index was used for repeated measurements and follow-up. The increased spectral performance with augmented vagal activity and slope down of sympatho-vagal ratio are evident after blood pressure control achievement. Improvement of functional age parameter associated with blood pressure compensation is visible using a complex age-dependent parameters interpretation.


CONCLUSIONS
HRV evaluation in hypertensive patients provides new parameters for patient's examination. These parameters are influenced by both the illness itself and by pharmacotherapy. Such an approach offers more complex information about patient.
Galuszka
Jan
J
Ist Department of Internal Medicine, Teaching Hospital and Palacky University, Olomouc, Czech Republic. Jan.Galuszka@fnol.cz
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D011187:Posture / Q000502:physiology*; D016683:Supine Position / Q000502:physiology; D014630:Vagus Nerve / Q000503:physiopathology
D000959:Antihypertensive Agents