Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity.
TRPV1 is a sensory transduction channel that mediates thermal nociception and some aspects of pathological pain. In this issue of Neuron, Gibson et al. report that TRPV1 also plays important roles in hippocampal synaptic plasticity, presenting a potential challenge for TRPV1-targeted therapeutics for the treatment of pain.
Alter
Benedict J
BJ
Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gereau
Robert W
RW
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D050916:TRPV Cation Channels / Q000502:physiology*
D050916:TRPV Cation Channels; C494484:TRPV1 receptor