title: Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats.
abstract: We studied the effects of a single oral administration of ferulic acid (FA) on the blood pressure (BP) and lipid profile in stroke-prone spontaneously hypertensive rats (SHRSP). Male 12-week-old SHRSP were administered FA (9.5 mg/kg of body weight) and distilled water as the control (C) (1 mL) via a gastric tube. The hypotensive effect of FA was observed at the lowest value after 2 h administration. A decrease in the angiotensin-1-converting enzyme (ACE) activity in the plasma corresponded well with the reduction of BP. Plasma total cholesterol and triglyceride levels were lower after 2 h administration. The mRNA expression of genes involved in lipid and drug metabolism was downregulated in the FA group. These results suggest that oral administration of FA appears beneficial in improving hypertension and hyperlipidemia.
authors.affiliation: Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan. ardy@biochem.tohoku.ac.jp
authors.lastname: Ardiansyah
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Koseki
authors.forename: Michio
authors.initials: M
authors.lastname: Komai
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003373:Coumaric Acids / Q000008:administration & dosage*; D020022:Genetic Predisposition to Disease; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000235:genetics
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003373:Coumaric Acids; D008055:Lipids; D012333:RNA, Messenger; C004999:ferulic acid; D007703:Peptidyl-Dipeptidase A