Analytical methodologies for the determination of cisplatin.
cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m(2) (21 days). A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples.
Bosch
M Espinosa
ME
Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot s/n, 41013 Sevilla, Spain.
Sánchez
A J Ruiz
AJ
Rojas
F Sánchez
FS
Ojeda
C Bosch
CB
D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000032:analysis*; D004563:Electrochemistry; D019075:Electrophoresis, Capillary; D013058:Mass Spectrometry; D013056:Spectrophotometry, Ultraviolet
D002945:Cisplatin