Keloids: pathophysiology and management.
Keloid formation occurs as a result of abnormal wound healing. Despite the high prevalence of keloids in the general population, they remain one of the more challenging dermatologic conditions to manage. More than a cosmetic nuisance, they are often symptomatic and can have a significant psychosocial burden for the patient. Although multiple treatment modalities exist, no single treatment has proven widely effective. In fact, recurrence following treatment is generally the norm. Combination therapy is likely the optimal strategy. In this review, we highlight the clinical features, pathophysiology and management of keloids.
Robles
David T
DT
Department of Medicine, Division of Dermatology, University of Washington Medical Center, Seattle, USA.
Moore
Erin
E
Draznin
Michelle
M
Berg
Daniel
D
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000287:Administration, Topical; D000818:Animals; D017209:Apoptosis; D001458:Bandages; D003094:Collagen / Q000096:biosynthesis; D017679:Cryotherapy / Q000379:methods*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis; D007627:Keloid / Q000209:etiology / Q000473:pathology / Q000628:therapy; D028022:Low-Level Light Therapy / Q000379:methods*; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012307:Risk Factors; D020034:Silicone Gels / Q000008:administration & dosage*; D013514:Surgical Procedures, Operative / Q000379:methods*; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications
D000276:Adjuvants, Immunologic; D005938:Glucocorticoids; D036341:Intercellular Signaling Peptides and Proteins; D020034:Silicone Gels; D003094:Collagen