The potential of lipid- and polymer-based drug delivery carriers for eradicating biofilm consortia on device-related nosocomial infections.
Microbial biofilms are microcosm attaching irreversibly to abiotic or biotic surfaces and they are promulgated as congregate of single or multiple populations. The potential of lipid- and polymer-based drug delivery carriers for eradicating biofilm consortia on device-related nosocomial infections is explored in this review. Liposomes-loaded with antimicrobial agents could effectively be applied as anti-biofilm coating to reduce microbial adhesion/colonisation onto medical devices and as drug delivery carriers to biofilm interfaces and in intracellular infection. Many polymer-based carrier systems have also been proposed, including those based on biodegradable polymers such as poly(lactide co-glycolide) as well as fibrous scaffolds and thermoreversible hydrogels and surface (properties) modified polymeric catheter materials such as antimicrobial, antiseptic or metallic substances-coated polymeric materials. Their contribution to the prevention/resolution of infection is reviewed.
Tamilvanan
Shunmugaperumal
S
Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium. tamilvanan2k@yahoo.com
Venkateshan
Narayanan
N
Ludwig
Annick
A
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001422:Bacterial Adhesion; D018441:Biofilms; D003428:Cross Infection / Q000517:prevention & control*; D004337:Drug Carriers / Q000627:therapeutic use*; D004864:Equipment and Supplies / Q000382:microbiology*; D006801:Humans; D008055:Lipids; D008081:Liposomes / Q000627:therapeutic use*; D011108:Polymers
D000890:Anti-Infective Agents; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D011108:Polymers