title: Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus.
abstract: OBJECTIVE
  To compare the postprandial lipid responses in subjects with prediabetes (IFG and IGT), newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT).
  
  
  METHODS
  Postprandial lipid responses to a standard oral fat challenge was studied in forty-four subjects who were divided after an OGTT into NGT, pure impaired fasting glucose (PIFG), pure impaired glucose tolerance (PIGT) and NDDM.
  
  
  RESULTS
  There was a significantly higher postprandial triglyceride (PPTg) response with a higher PPTg area under curve (p=0.004) and peak PPTg levels (p=0.003) in patients with NDDM but not with either PIFG (p>0.05) or PIGT (p>0.05) when compared with NGT. Overall, PPTg responses correlated significantly with fasting plasma glucose (p=0.001) and 2h plasma glucose (p=0.001) but not with age, sex, body mass index, waist, or insulin resistance.
  
  
  CONCLUSIONS
  Subjects with newly detected diabetes mellitus displayed postprandial hypertriglyceridemia after a standard oral fat meal challenge while no such abnormality could be demonstrated in subjects with IFG or IGT. This defect is probably related to glycemic status and insulin resistance.
authors.affiliation: Department of Medicine, University College of Medical Sciences and GTB Hospital, Shahdara, Delhi, India. drsvmadhu@gmail.com
authors.forename: S V
authors.initials: SV
authors.lastname: Madhu
authors.forename: S
authors.initials: S
authors.lastname: Kant
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: R
authors.initials: R
authors.lastname: Kant
authors.forename: S B
authors.initials: SB
authors.lastname: Sharma
authors.forename: D P
authors.initials: DP
authors.lastname: Bhadoria
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol