title: Potential antitumoral properties of a new copper complex with santonic acid.
abstract: A new copper(II) complex of santonic acid [Cu(2)(sant)(4)(H(2)O)(2)].2(1/2)H(2)O has been prepared and characterized by electronic, vibrational, EPR spectral studies, and stability determinations in solution. The presence of two antiferrromagnetically coupled copper centers in the solid state was detected by EPR. The dinuclear Cu(II) complex crystallizes in the tetragonal P4(3)2(1)2 space group, with a=b=14.498(3), c=64.07(1)A. Biological studies indicate that the complex displays interesting potential antitumoral actions.
authors.affiliation: Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C. Correo 962, 1900 La Plata, Argentina.
authors.forename: Patricia A M
authors.initials: PA
authors.lastname: Williams
authors.forename: Juan
authors.initials: J
authors.lastname: Zinczuk
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Barrio
authors.forename: Oscar E
authors.initials: OE
authors.lastname: Piro
authors.forename: Otaciro R
authors.initials: OR
authors.lastname: Nascimento
authors.forename: Susana B
authors.initials: SB
authors.lastname: Etcheverry
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D013329:Structure-Activity Relationship; D014732:Vibration
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; C490150:santonic acid; D003300:Copper