Sleep: dozy worms and sleepy flies.
Recent work on quiescent states in Caenorhabditis elegans suggests that worms exhibit behaviours reminiscent of satiety and sleep in mammals. At a molecular level, signalling through the EGF receptor and protein kinase G promotes quiescent states in both worms and flies, suggesting conserved mechanisms for sleep-like behaviours.
Olofsson
Birgitta
B
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
de Bono
Mario
M
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism; D004330:Drosophila / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism; D012528:Satiety Response / Q000502:physiology; D012890:Sleep / Q000502:physiology*
D066246:ErbB Receptors; D017869:Cyclic GMP-Dependent Protein Kinases