Regioselective palladium cross-coupling of 2,4-dihalooxazoles: convergent synthesis of trisoxazoles.
A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles in high yield and in a minimum number of steps.
Flegeau
Emmanuel Ferrer
EF
School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
Popkin
Matthew E
ME
Greaney
Michael F
MF
D001966:Bromine / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D003432:Cross-Linking Reagents; D010080:Oxazoles; D010165:Palladium; D007455:Iodine; D001966:Bromine