Synthesis of 1-{4-[4-(adamant-1-yl)phenoxymethyl]-2-(4-bromophenyl)- 1,3-dioxolan-2-ylmethyl}imidazole with expected antifungal and antibacterial activity.
A multistep synthesis of a new analogue of ketoconazole, which was expected to show antifungal and antibacterial activity, has been described.
Płachta
Dariusz A
DA
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
Baranowski
Andrzej M
AM
Laudy
Agnieszka E
AE
Starościak
Bohdan J
BJ
Kleps
Jerzy
J
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004347:Drug Interactions; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
C528078:1-(4-(4-(adamant-1-yl)phenoxymethyl)-2-(4-bromophenyl)-1,3-dioxolan-2-ylmethyl)imidazole; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007093:Imidazoles; D000218:Adamantane