title: [Lights and shades in the application of new guidelines for the management of type 2 diabetes mellitus. Practical advice about combined therapy and insulin therapy].
abstract: Type 2 diabetes is a disease with an increasing prevalence due to the ageing and sedentary lifestyle of the general population. Its associated with the risk of developing a series of chronic complications in mid/long-term. The current guidelines recommend certain therapy targets that have proven difficult to achieve due to poor compliance or because doctors do not always adhere to expert guidelines. The inability to achieve an adequate glycemic control in the course of diabetes may result in part from the typical conservative stepwise treatment approach that includes monotherapy initiated alter failure of diet and exercise, followed by a combination of oral antiglycemic agents, and ultimately insulin therapy. With respect to insulin therapy, the availability of different analogues as well as the new routes of administration (e.g., inhaled insulin) may allow the early introduction of this therapy, which may be more readily accepted by the patient.
authors.affiliation: Unidad de Riesgo Cardiometabólico y Patología Endotelial, Servicio de Medicina Interna, Hospital Ramón y Cajal, Madrid, España.
authors.forename: Olivia
authors.initials: O
authors.lastname: Sánchez Sánchez
authors.forename: José
authors.initials: J
authors.lastname: Sabán Ruiz
mesh_terms: D003663:Decision Trees; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin