Short alpha/beta-peptides as catalysts for intra- and intermolecular aldol reactions.
Short alpha/beta-peptides, containing conformationally restricted cis-beta-aminocyclopropylcarboxylic acid units as turn-inducing elements, have been found to be efficient catalysts for inter- and intramolecular aldol reactions. The tripeptide H-(L)-Pro-black triangle-(L)-Pro-OH was identified to perform especially well in homogeneous and heterogeneous aqueous solutions as well as in organic solvents.
D'Elia
Valerio
V
Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
Zwicknagl
Hans
H
Reiser
Oliver
O
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry
D000447:Aldehydes; D007659:Ketones; D010455:Peptides; C116609:3-hydroxybutanal; D011392:Proline