Solubilisation of [60]fullerenes using block copolymers and evaluation of their photodynamic activities.
Unmodified [60]fullerenes (C60) were solubilised with high stability using various type of poly(ethylene glycol) (PEG) based block copolymer micelles. Block copolymer micelle-incorporated C60 fullerenes were studied in cultures for biological activities using human cervical cancer HeLa cells. As a result, the cationic block copolymer micelles delivered C60 into the cells depending on their surface densities and showed cytotoxicity under photoirradiation.
Akiyama
Motofusa
M
Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
Ikeda
Atsushi
A
Shintani
Takashi
T
Doi
Yuki
Y
Kikuchi
Jun-Ichi
J
Ogawa
Takuya
T
Yogo
Keiichiro
K
Takeya
Tatsuo
T
Yamamoto
Naoyuki
N
D017209:Apoptosis / Q000187:drug effects; D002412:Cations; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008823:Micelles; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D002412:Cations; D037741:Fullerenes; D008823:Micelles; D017319:Photosensitizing Agents; D011108:Polymers; D011092:Polyethylene Glycols; C069837:fullerene C60