title: Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery.
abstract: This report describes a patient who developed a corneal melt after the use of nepafenac, a nonsteroidal antiinflammatory drug. An 82-year-old woman with chronic cystoid macular edema after cataract extraction and intraocular lens implantation in the left eye, which was clinically controlled with a topical nonsteroidal antiinflammatory drug, was initially treated with diclofenac sodium 0.1% before being treated with nepafenac 0.1%. After 5 months of nepafenac use, the patient complained of pain, a foreign body sensation, and decreased vision in her left eye. The left eye showed a peripheral corneal ulcer with no stromal cell infiltration. The corneal ulcer was scraped and cultured to show epithelial cells and neutrophils with no growth of microorganisms. The nepafenac was discontinued, and a topical antibiotic and lubrication were used. After 2 months, the patient's visual acuity improved, and she had an intact epithelium and stable corneal thinning. To the authors' knowledge, this is the first case report of a corneal melt after the prolonged use of nepafenac to treat cystoid macular edema.
authors.affiliation: Department of Ophthalmology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9057, USA.
authors.forename: Mario A
authors.initials: MA
authors.lastname: Di Pascuale
authors.forename: Jess T
authors.initials: JT
authors.lastname: Whitson
authors.forename: V Vinod
authors.initials: VV
authors.lastname: Mootha
mesh_terms: D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D044482:Benzeneacetamides / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000188:drug therapy / Q000209:etiology; D010648:Phenylacetates / Q000009:adverse effects*; D014792:Visual Acuity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac