[Critical analysis on the use of the homeostasis model assessment (HOMA) indexes in the evaluation of the insulin resistance and the pancreatic beta cells functional capacity].
Beta-cell dysfunction and insulin resistance are interrelated metabolic abnormalities in the aetiology of Type 2 Diabetes. In several countries, increases in the prevalence of obesity and diabetes have been observed in association with the presence of insulin resistance. In this context, measurement of insulin resistance and beta-cell function is useful. The HOMA indexes (Homeostasis Model Assessment) have been widely used, representing an alternative for the evaluation of these parameters, particularly as a fast, easy and cheap method. This review discusses the origin and evolution of the HOMA index, as well as details of the method, analyzing features related to its validation and the cutoff limits for its interpretation.
Vasques
Ana Carolina J
AC
Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, MG, Brazil. anacarolinavasques@yahoo.com.br
Rosado
Lina Enriqueta F P L
LE
Cássia GAlfenas
Rita de
Rd
Geloneze
Bruno
B
D000818:Animals; D015309:Glucose Clamp Technique / Q000379:methods* / Q000592:standards; D005951:Glucose Tolerance Test / Q000592:standards; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D054928:Validation Studies as Topic
D007328:Insulin