Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation.
BACKGROUND
Calciphylaxis and calcinosis can both cause severe morbidity and mortality in patients with systemic lupus erythematosus (SLE). Haematopoietic stem cell transplantation (HSCT) has been successfully used to treat patients with refractory SLE. It was hypothesized that in calciphylaxis and calcinosis, ongoing inflammatory activity contributes to the calcium deposition in the media of small arteries, as well as perivascular and periarticular tissues. We report three patients whose soft-tissue calcification syndromes dramatically resolved after undergoing HSCT.


METHODS
Three patients referred for refractory SLE underwent HSCT at a tertiary care medical center. SLE serologies and clinical features before and after HSCT were recorded.


RESULTS
Despite receiving >6 months of intravenous cyclophosphamide (CYC), three SLE patients showed signs of persistent lupus activity, including severe soft-tissue calcification. The first patient was on haemodialysis and developed severe calciphylaxis with large ulcers and tissue necrosis. The second patient had calcinosis, with palpable crystals extruding from ulcers. The third patient had calcinosis characterized by subcutaneous nodules and plaques. Because prior conventional therapies had failed, the three were treated with high-dose CYC, anti-thymocyte globulin and HSCT. They have been followed post-HSCT for 26-38 months, with excellent clinical responses, including sustained resolution of skin abnormalities.


CONCLUSIONS
The successful treatment of advanced calcium deposition by aggressive immune ablation underscores the contribution of SLE-mediated inflammation to soft-tissue calcification syndromes.
Mandelbrot
Didier A
DA
Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. dmandelb@bidmc.harvard.edu
Santos
Peter W
PW
Burt
Richard K
RK
Oyama
Yu
Y
Block
Geoffrey A
GA
Ahya
Shubhada N
SN
Rosa
Robert M
RM
Traynor
Ann E
AE
D000293:Adolescent; D000328:Adult; D001132:Arm; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D002115:Calciphylaxis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003240:Connective Tissue Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007866:Leg; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy