title: [Clinical experience with efalizumab in the Hospital of Cruces].
abstract: Efalizumab (Raptiva) is one of the biological agents approved recently for the treatment of patients with moderate-severe psoriasis who have not responded to conventional treatments. It is a humanized IgG1 monoclonal antibody which, due to its anti-D11 effect, is capable of blocking the endothelial migration and T cell activation on the skin, fundamental processes in the etiopathogeny of psoriasis. We present the experience we have had in our hospital over the last two years with 23 patients who have initiated treatment with efalizumab.
authors.affiliation: Servicio de Dermatología, Hospital de Cruces, Vizcaya, España. ZURINE.MARTINEZDELAGRANALVAREZDEARCAYA@osakidetza.net
authors.forename: Z
authors.initials: Z
authors.lastname: Martínez de Lagrán
authors.forename: M R
authors.initials: MR
authors.lastname: González Hermosa
authors.forename: J L
authors.initials: JL
authors.lastname: Díaz-Pérez
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use; D003873:Dermatitis, Exfoliative / Q000209:etiology; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006786:Hospitals, Urban; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000628:therapy*; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001688:Biological Products; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C472181:efalizumab