Multicellular dynamics during epithelial elongation.
The reorganization of multicellular populations to produce an elongated tissue structure is a conserved mechanism for shaping the body axis and several organ systems. In the Drosophila germband epithelium, this process is accompanied by the formation of a planar polarized network of junctional and cytoskeletal proteins in response to striped patterns of gene expression. Actomyosin cables and adherens junctions are dynamically remodeled during intercalation, providing the basis for polarized cell behavior. Quantitative analysis of cell behavior in living embryos reveals unexpected cell population dynamics that include the formation of multicellular rosette structures as well as local neighbor exchange.
Zallen
Jennifer A
JA
Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA. zallenj@mskcc.org
Blankenship
J Todd
JT
D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology; D004847:Epithelial Cells / Q000166:cytology*