[Kinoids: a novel generation of specific immune therapy against cytokines].
The abnormal cytokine release in the stromal microenvironment of pathologic tissues, contributes to the pathogenesis of viral infections such as AIDS, cancer and auto-immune diseases. Neovacs developed therapeutic vaccines, named Kinoids, which induce anti-cytokine Antibodies. Kinoids are non toxic but immunogenic cytokine derivatives. Kinoid immunizations induce high titre of neutralizing Abs to the corresponding cytokine, is well tolerated and experimentally effective. In transgenic mice expressing huTNFalpha, the TNFalpha kinoid decreases clinical signs of Rheumatoid Arthritis and in mice challenged with syngenic CT26 tumor cell line huVEGF kinoid inhibits lung metastases. After validation by clinical trials, kinoid vaccines could represent a second generation of specific immune therapy to be used to combat ectopic cytokines.
Bensussan
Armand
A
Institut National de la Santé et de la Recherche Médicale, Inserm U841, Créteil, France. armand.bensussan@creteil.inserm.fr
Bizzini
Bernard
B
Pouletty
Philippe
P
Gallo
Robert C
RC
Zagury
Daniel
D
D000818:Animals; D000915:Antibody Affinity; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology / Q000628:therapy; D006801:Humans; D016233:Immunotherapy, Active; D016898:Interferon-alpha / Q000037:antagonists & inhibitors / Q000276:immunology; D015847:Interleukin-4 / Q000037:antagonists & inhibitors / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D009500:Neutralization Tests; D012958:Societies, Scientific; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000276:immunology
D016207:Cytokines; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D014612:Vaccines; D042461:Vascular Endothelial Growth Factor A; D015847:Interleukin-4