title: The expression of CD2 in chronic HBV infection.
abstract: It was previously reported that several kinds of intercellular adhesion molecules are closely related to chronic HBV infection. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. In this study, we detected the level of CD2 expressed on the surface of PBMC, the expression level of CD2 mRNA in PBMC and the percentage of CD2 positive cells in PBMC of patients with chronic HBV infection and compared them with the expression level of normal controls. We also determined the level of serum HBV DNA from patients with chronic HBV infection and from normal controls. The clinical characteristics of hepatic function were tested as well. The results showed that the expression of CD2 significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection.
authors.affiliation: Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Baotai
authors.initials: B
authors.lastname: Qi
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Linjing
authors.initials: L
authors.lastname: He
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Ji
authors.forename: Ming
authors.initials: M
authors.lastname: Xie
mesh_terms: D000328:Adult; D018801:CD2 Antigens / Q000276:immunology / Q000378:metabolism*; D018968:CD58 Antigens / Q000276:immunology / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006515:Hepatitis B virus / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000821:virology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D018801:CD2 Antigens; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules; D004279:DNA, Viral; D012333:RNA, Messenger