Changing patterns of serum and bile antibodies in re-infected rats with Clonorchis sinensis.
Rats develop strong resistance to re-infection and super-infection by Clonorchis sinensis. The present study investigated the antibodies present in the sera and bile juice of rats that were primary infected and re-infected with C. sinensis. The serum level of specific IgG antibodies, which were elevated 2 wk of the primary infection, peaked at 4 wk and subsequently remained unchanged even during re-infection. The total IgE level in serum increased slowly from 388 ng / ml to 3,426 ng / ml beginning 2 wk after the primary infection, and remained high up to 8 wk but dropped to a normal level (259 ng / ml) after treatment. In resistant re-infected rats, the serum IgE level increased rapidly and peaked within 1 wk, whereas no increase was observed in immunosuppressed rats. The serum level of specific IgA antibodies was elevated beginning 1 wk after infection, and decreased 4 wk after treatment. The total bile IgA level unchanged during the primary infection but increased in treated and re-infected rats. The elevated levels of serum IgE and bile IgA indicate that these immunoglobulins may be correlated with the development of resistance to re-infection by C. sinensis in rats.
Zhang
Hongman
H
Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Republic of Korea.
Chung
Byung Suk
BS
Li
Shunyu
S
Choi
Min Ho
MH
Hong
Sung Tae
ST
D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis / Q000097:blood* / Q000276:immunology* / Q000378:metabolism; D001646:Bile / Q000276:immunology*; D003003:Clonorchiasis / Q000097:blood / Q000276:immunology*; D003004:Clonorchis sinensis / Q000276:immunology* / Q000502:physiology*; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000909:Antibodies, Helminth; D007070:Immunoglobulin A