Comparison of pro B-natriuretic peptide in hypertensive patients with and without diastolic dysfunction.
OBJECTIVE
to evaluate whether pro BNP can be used for detection of diastolic dysfunction.


METHODS
thirty nine hypertensive patients with normal systolic function, consecutively referred for echocardiography examination between October and December 2004 were recruited in the study. Diastolic dysfunction was diagnosed when echocardiographic mitral flow pattern demonstrated impaired relaxation, pseudonormalization or restrictive like patterns. NT-pro BNP levels were assessed using electro chemiluminescence Immunoassay (ECLIA) method. Unpaired t test was used to analyze the results.


RESULTS
twelve out of thirty nine subjects had normal diastolic function. All base line characteristics, except for uric acid, were equally distributed between normal and abnormal diastolic function group. NT-pro BNP levels were nearly significantly higher in the diastolic dysfunction group (P=0.053).


CONCLUSIONS
NT-pro BNP levels trends to be higher in hypertensive subjects with diastolic dysfunction.
Santosa
Yudistira P
YP
Department of Internal Medicine, Faculty of Medicine Atmajaya University, Jl. Pluit Raya no. 2, Jakarta. yudipsan@yahoo.com
Tjandrawati
Anna
A
Noormartany
Erwinanto
Yahya
Ahmad F
AF
Martanto
Erwan
E
Tedjokusumo
Pintoko
P
Purnomowati
Augustine
A
Antono
Eko
E
D003971:Diastole / Q000502:physiology*; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain