title: Neurological complications of celiac disease and autoimmune mechanisms: a prospective study.
abstract: Humoral immune mechanisms may have a role in the neurological complications of celiac disease (CD). We assessed 71 CD patients for neurologic manifestations and presence of serum antibodies to neural antigens. Sixteen patients (22.5%) were found to have neurological deficits including headache, depression, entrapment syndromes, peripheral neuropathy, and epilepsy. Antibody reactivity to neural antigens was detected in 30/71 (42.2%) patients. There was no clear correlation between anti-neural reactivity and neurologic dysfunction. Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet.
authors.affiliation: Department of Neurosciences, University of Padova, Padova, Italy. chiara.briani@unipd.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Briani
authors.forename: Gabriella
authors.initials: G
authors.lastname: Zara
authors.forename: Armin
authors.initials: A
authors.lastname: Alaedini
authors.forename: Francesca
authors.initials: F
authors.lastname: Grassivaro
authors.forename: Susanna
authors.initials: S
authors.lastname: Ruggero
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Toffanin
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Albergoni
authors.forename: Milena
authors.initials: M
authors.lastname: Luca
authors.forename: Bruno
authors.initials: B
authors.lastname: Giometto
authors.forename: Mario
authors.initials: M
authors.lastname: Ermani
authors.forename: Franca
authors.initials: F
authors.lastname: De Lazzari
authors.forename: Anna
authors.initials: A
authors.lastname: D'Odorico
authors.forename: Leontino
authors.initials: L
authors.lastname: Battistin
mesh_terms: D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000328:Adult; D000906:Antibodies / Q000097:blood; D001772:Blood Cell Count; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D019204:GTP-Binding Proteins; D005732:Gangliosides / Q000276:immunology; D005903:Gliadin / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000145:classification / Q000209:etiology* / Q000276:immunology*; D009431:Neural Conduction / Q000502:physiology; D011446:Prospective Studies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology
chemical_list: D000906:Antibodies; D005732:Gangliosides; D006680:HLA Antigens; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins