title: Longitudinal study of umbilical and portal venous blood flow to the fetal liver: low pregnancy weight gain is associated with preferential supply to the fetal left liver lobe.
abstract: Recent data suggest that umbilical venous perfusion of the fetal liver has an important influence on fetal growth and postnatal liver function, and that maternal factors in late pregnancy modify this circulation. In a longitudinal study of 160 low-risk pregnancies, we determined how umbilical and portal venous blood flows to the fetal liver changed during gestation, and examined the hypothesis that maternal body mass index and pregnancy weight gain influenced fetal liver blood flows. We measured blood flows in the umbilical and portal veins, left portal branch, and ductus venosus using ultrasound. Normalizing for estimated fetal weight, fetal liver total venous blood flow fell from 84 to 57 mL. min(-1). kg(-1) during 21-39 wk of gestation; toward term the portal contribution increased (from 14 to 20%) and the umbilical contribution fell, whereas distribution between the left and right liver lobes was stable, 60%/40%. Greater flow of nutrient-rich umbilical venous blood to the liver was associated with higher birth weight and neonatal ponderal index. Maternal body mass index was not related to fetal liver blood flows, but low pregnancy weight gain strongly influenced flow distribution between the right and left liver lobes, sparing the left lobe and increasing the difference between lobes by 16%.
authors.affiliation: Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway. jorg.kessler@kk.uib.no
authors.forename: Jörg
authors.initials: J
authors.lastname: Kessler
authors.forename: Svein
authors.initials: S
authors.lastname: Rasmussen
authors.forename: Keith
authors.initials: K
authors.lastname: Godfrey
authors.forename: Mark
authors.initials: M
authors.lastname: Hanson
authors.forename: Torvid
authors.initials: T
authors.lastname: Kiserud
mesh_terms: D001724:Birth Weight; D001783:Blood Flow Velocity; D015992:Body Mass Index; D005260:Female; D005865:Gestational Age; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000196:embryology; D008102:Liver Circulation; D008137:Longitudinal Studies; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000196:embryology / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012039:Regional Blood Flow; D014463:Ultrasonography; D014471:Umbilical Veins / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015430:Weight Gain