Cost-saving treatment strategies in in vitro fertilization: a combined economic evaluation of two large randomized clinical trials comparing highly purified human menopausal gonadotropin and recombinant follicle-stimulating hormone alpha.
OBJECTIVE
To assess the cost-effectiveness of two gonadotropin treatments that are available in the United Kingdom in light of limited public funding and the fundamental role of costs in IVF treatment decisions.


METHODS
An economic evaluation based on two large randomized clinical trials in IVF patients using a simulation model.


METHODS
Fifty-three fertility clinics in 13 European countries and Israel.


METHODS
Women indicated for treatment with IVF (N = 986), aged 18-38, participating in double-blind, randomized controlled trials.


METHODS
Highly purified menotropin (HP-hMG, Menopur) or recombinant follitropin alpha (rFSH, Gonal-F).


METHODS
Cost per IVF cycle and cost per live birth for HP-hMG and rFSH alpha.


RESULTS
HP-hMG was more effective and less costly versus rFSH for both IVF cost per live birth and for IVF cost per baby (incremental cost-effectiveness ratio was negative). The mean costs per IVF treatment for HP-hMG and rFSH were 2408 pounds (95% confidence interval [CI], 2392 pounds, 2421 pounds) and 2660 pounds (95% CI 2644 pounds, 2678 pounds), respectively. The mean cost saving of 253 pounds per cycle using HP-hMG allows one additional cycle to be delivered for every 9.5 cycles.


CONCLUSIONS
Treatment with HP-hMG was dominant compared with rFSH in the United Kingdom. Gonadotropin costs should be considered alongside live-birth rates to optimize outcomes using scarce health-care resources.
Wechowski
Jaroslaw
J
Health Economics, Cardiff Research Consortium, Cardiff, United Kingdom.
Connolly
Mark
M
Schneider
Dirk
D
McEwan
Philip
P
Kennedy
Richard
R
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D003198:Computer Simulation; D017046:Cost Savings / Q000379:methods; D003362:Cost-Benefit Analysis; D004311:Double-Blind Method; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics* / Q000379:methods; D015292:Glycoprotein Hormones, alpha Subunit / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D015233:Models, Statistical; D011994:Recombinant Proteins / Q000191:economics / Q000627:therapeutic use*; D055815:Young Adult
D015292:Glycoprotein Hormones, alpha Subunit; D011994:Recombinant Proteins; D008596:Menotropins