title: [Pathological neocortical findings in patients with medication-resistant medial temporal lobe epilepsy submitted to surgery].
abstract: BACKGROUND
  The dual pathology consisting of hippocampal sclerosis plus focal cortical dysplasia (FCD) is often reported in patients with medication-resistant medial temporal lobe epilepsy (MTLE).
  
  
  OBJECTIVE
  To determine the histopathological changes that take place in the neocortex of patients with medication-resistant MTLE submitted to surgery and to evaluate the relation between the histopathological changes, pathological background and the clinical course of patients who had received surgical treatment.
  
  
  METHODS
  Tissue obtained by en bloc resection from the neocortex of 18 patients with MTLE refractory to medical treatment was processed histologically and a tailored temporal lobectomy was performed with electrocorticography.
  
  
  RESULTS
  Dual pathology was diagnosed in 13 patients (72.2%). Imaging studies confirmed the existence of mesial sclerosis of the temporal in 100% of cases and there was no evidence of neocortical lesions. Histologically, 46.15% and 38.46% of the patients were diagnosed as belonging to FCD type 1a and FCD type 1b, respectively. Only one patient presented FCD type 2a. A statistically significant relation was found between the presence of dual pathology and the existence of an early precipitating injury (p = 0.04). One year after surgery, 72.7% (8/11) patients with dual pathology were classified as belonging to Engel class I.
  
  
  CONCLUSIONS
  In patients with MTLE there are microscopic FCD-type alterations in the neocortex. There is an association between these alterations and the existence of an initial precipitating injury. Complete resection of the epileptogenic area, which is guaranteed by the lobectomy tailored by electrocorticography, allows patients to enjoy a favourable post-surgical progression one year after surgery.
authors.affiliation: Laboratorio de Anatomía Patológica, Centro Internacional de Restauración Neurológica, Ciudad de La Habana, Cuba. barbarae.diaz@infomed.sld.cu
authors.forename: B
authors.initials: B
authors.lastname: Estupiñán-Díaz
authors.forename: L M
authors.initials: LM
authors.lastname: Morales-Chacón
authors.forename: L
authors.initials: L
authors.lastname: Lorigados-Pedre
authors.forename: I
authors.initials: I
authors.lastname: García-Maeso
authors.forename: J E
authors.initials: JE
authors.lastname: Bender-del Busto
authors.forename: O
authors.initials: O
authors.lastname: Trápaga-Quincoses
authors.forename: L
authors.initials: L
authors.lastname: Hidalgo-Portal
authors.forename: M E
authors.initials: ME
authors.lastname: García-Navarro
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Coroneaux
authors.forename: S
authors.initials: S
authors.lastname: Orozco-Suárez
mesh_terms: D000328:Adult; D004351:Drug Resistance; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000473:pathology*