Short-term plasticity of central benzodiazepine receptors in status epilepticus: case report.
(123)I-iomazenil SPECT is of value in determining an epileptogenic focus, however, transient uptake change has been rarely reported in epileptic disorders. A 78-year-old woman diagnosed as status epilepticus (SE) showed transient reduction in (123)I-iomazenil uptake within the epileptic foci on SPECT images during a couple of weeks. It suggests a seizure-related 'short-term' plasticity in the central benzodiazepine receptors and dynamic change in the regulatory mechanisms of inhibitory neurotransmitter system within the epileptic foci in patients with SE.
Amemiya
S
S
Division of Neurology, Nephrology and Rheumatology, Internal Medicine, Nippon Medical School, Tokyo, Japan. amemiya@nms.ac.jp
Hamamoto
M
M
Mishina
M
M
Ueda
M
M
Kumagai
T
T
Nishiyama
Y
Y
Katayama
Y
Y
D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D015536:Down-Regulation; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009433:Neural Inhibition; D009473:Neuronal Plasticity; D011237:Predictive Value of Tests; D011963:Receptors, GABA-A / Q000378:metabolism*; D013226:Status Epilepticus / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D009435:Synaptic Transmission; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D015415:Biomarkers; D007457:Iodine Radioisotopes; D011963:Receptors, GABA-A; D005442:Flumazenil; D005680:gamma-Aminobutyric Acid; C063038:iomazenil