title: Distribution of adrenomedullin-like immunoreactivity in the brain of the adult sea lamprey.
abstract: Adrenomedullin (AM) is a neuropeptide widely distributed in vertebrates. In jawed vertebrates it has been localized in distinct regions of the central nervous system by means of antisera against human AM because the molecule seems to be well conserved across species. In this study, we have analyzed the localization of AM-like immunoreactive (AM-ir) cell bodies and fibers throughout the brain of the adult sea lamprey Petromyzon marinus, by using immunohistochemistry. Several AM-ir cell populations were found in the basal plate of the secondary prosencephalon, being more numerous in the hypothalamus, as well as two in the diencephalon and one in the mesencephalon; in addition two cell populations were found in the rhombencephalic alar plate, one in the isthmic region and other in the nucleus of the solitary tract. Immunolabeled fibers were widespread throughout the lamprey brain, but were more abundant in the basal plate. Of particular interest was the conspicuous innervation of the striatum by AM-ir fibers. In addition, our results indicate that AM-ir cells and fibers are present in the lamprey hypothalamo-neurohypophyseal system, suggesting that AM plays some important role in the control of pituitary gland function.
authors.affiliation: Neurolam Group, Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, 36310 Vigo, Spain. pombal@uvigo.es
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Pombal
authors.forename: Jesús M
authors.initials: JM
authors.lastname: López
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: de Arriba
authors.forename: Agustín
authors.initials: A
authors.lastname: González
authors.forename: Manuel
authors.initials: M
authors.lastname: Megías
mesh_terms: D053607:Adrenomedullin / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D048428:Petromyzon / Q000033:anatomy & histology* / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; C104782:adrenomedullin (22-52); D053607:Adrenomedullin