title: [Preparation of alpha-hydrocycholic-beta-cyclodextrin inclusion compound].
abstract: OBJECTIVE
  To study the preparation of alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound.
  
  
  METHODS
  It was studied with orthogonal design to analysis three factors of inclusion rate such as the weight ratio between HDCA and beta-Cyclodextrin, the temperature and the reaction time. Fourier transform infrared spectroscopy, scanning electron microscopy, taste and solubility test were used to identify the inclusion compound.
  
  
  RESULTS
  Stable inclusion compound was made by HDCA and beta-Cyclodextrin. The weight ratio between HDCA and beta-Cyclodextrin was the most important factor. The alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound taste and the solubility were improved.
  
  
  CONCLUSIONS
  The optimum preparation condition is alpha-Hydrocycholic : beta-Cyclodextrin = 8.67 : 1, the inclusion temperature is 60 degrees C and the inclusion time is 30 minutes.
authors.affiliation: Department of Pharmacy, Huai'an Second Hospital, Huai'an 223002, China. zqh67@163.com
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Bian
authors.forename: Dan-yan
authors.initials: DY
authors.lastname: Zhang
authors.forename: Qing-ping
authors.initials: QP
authors.lastname: Xiong
mesh_terms: D000704:Analysis of Variance; D003840:Deoxycholic Acid / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D047392:beta-Cyclodextrins; D003840:Deoxycholic Acid