title: Chiral amine-thioureas bearing multiple hydrogen bonding donors: highly efficient organocatalysts for asymmetric Michael addition of acetylacetone to nitroolefins.
abstract: New bifunctional organocatalysts amine-thioureas bearing multiple hydrogen bonding donors were synthesized and applied in catalytic asymmetric Michael addition of acetylacetone to aryl and alkyl nitroolefins. Multiple hydrogen bonding donors play a significant role in accelerating reactions, improving yields and enantioselectivities.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, 430072, China. cjwang@whu.edu.cn
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
authors.forename: Zhi-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010422:Pentanones / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000588:Amines; D007659:Ketones; D009574:Nitro Compounds; D010422:Pentanones; C008790:acetylacetone; D013890:Thiourea