title: Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma.
abstract: Cytogenetic correlations among most types of peripheral T-cell lymphoma (PTCL) have not been very informative to date. This study aimed to identify recurrent chromosomal abnormalities in angioimmunoblastic T-cell lymphoma (AITL), ALK-negative anaplastic large cell lymphoma (ALK-ALCL) and peripheral T-cell lymphoma, unspecified (PTCL-US), and to evaluate their prognostic value. We reviewed the cytogenetic findings of 90 previously-diagnosed cases of PTCL and correlated the cytogenetic findings with the specific histological subtype. The most common abnormalities for AITL were 5q (55%), 21 (41%) and 3q (36%) gains, concurrent trisomies of 5 and 21 (41%), and loss of 6q (23%). In ALK(-) ALCL, gains of 1q (50%) and 3p (30%), and losses of 16pter (50%), 6q13q21 (30%), 15 (30%), 16qter (30%) and 17p13 (30%) were frequent findings. In PTCL-US, frequent gains involved 7q22q31 (33%), 1q (24%), 3p (20%), 5p (20%), and 8q24qter (22%), and losses of 6q22q24 (26%) and 10p13pter (26%). We did not observe any association between specific chromosomal abnormalities and overall survival (OS). However, cases with complex karyotypes, most frequently observed in ALK(-) ALCL and PTCL-US, had a significantly shorter OS. Although, genetic differences were noted in these subtypes, further studies are needed to determine the key pathogenetic events in PTCL.
authors.affiliation: Human Genetics Laboratories, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198-5440, USA.
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Horsman
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Weisenburger
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
authors.forename: Bhavana J
authors.initials: BJ
authors.lastname: Dave
authors.forename: Fausto R
authors.initials: FR
authors.lastname: Loberiza
authors.forename: Olga
authors.initials: O
authors.lastname: Ludkovski
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Savage
authors.forename: James O
authors.initials: JO
authors.lastname: Armitage
authors.forename: Warren G
authors.initials: WG
authors.lastname: Sanger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics; D007621:Karyotyping; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis