[Clinical prospective study on maternal-fetal transmission of human bocavirus].
OBJECTIVE
To investigate maternal-fetal transmission at human bocavirus (HBoV).


METHODS
IgG antibody to HBoV in serum samples of 316 mothers were determined with ELISA and HBoV DNA was determined with real time PCR in the sera of the mothers and their infants.


RESULTS
HBoV-IgG was positive in 40.20 percent (127/316) of the mothers, while it was positive in 29.43 percent (93/316) of the cord blood specimens of the infants. The difference between the two groups was significant (X2=8.12, P less than 0.005); 93 samples of both the mothers and the infants were positive for HBoV-IgG.


CONCLUSIONS
HBoV-IgG can cross the placenta to the fetuses through placenta. Further study is needed to answer the question whether vertical maternal-fetal transmission occurs.
Zheng
Min-qiao
MQ
Wenling Hospital, Wenzhou Medical College, Wenzhou 317500, China.
Lin
Feng
F
Zheng
Mei-yun
MY
Chen
Hong
H
Zeng
Ai-ping
AP
Wu
Feng
F
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D052660:Bocavirus; D004279:DNA, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D010322:Parvoviridae Infections / Q000635:transmission*; D011247:Pregnancy; D011446:Prospective Studies
D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G