Brain perfusion abnormalities in a sibship with parkin-linked parkinsonism.
We demonstrated brain perfusion abnormalities in a sibship with parkin-linked parkinsonism. The sibship consisted of a 64-year-old man and a 62-year-old woman. Both patients had homozygous deletions of exon 4 in the parkin gene. Hypoperfusion in the superior and middle frontal gyrus, and head of caudate nucleus was seen by SPECT with easy Z score imaging system in both patients. These findings may reflect their executive dysfunction demonstrated by neuropsychological tests.
Kobayashi
Zen
Z
Department of Neurology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 180-8610, Japan.
Miake
Hirotomo
H
Fujigasaki
Hiroto
H
D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D001931:Brain Mapping; D005091:Exons; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D035781:Siblings; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein