title: Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers.
abstract: Littorachalcone (1) and diacid 10 were synthesized by direct routes. The antibacterial activity of 1, 10 and synthetic precursors were evaluated. Dialdehyde 3a showed potent antibacterial activity.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011, USA. gakraus@iastate.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Kraus
authors.forename: Ganesh
authors.initials: G
authors.lastname: Kumar
authors.forename: Gregory
authors.initials: G
authors.lastname: Phillips
authors.forename: Kris
authors.initials: K
authors.lastname: Michalson
authors.forename: Maria
authors.initials: M
authors.lastname: Mangano
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002599:Chalcone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D010647:Phenyl Ethers; D002599:Chalcone