Primary synovial sarcoma of the kidney: corroboration with in situ polymerase chain reaction.
Synovial sarcoma is a tumor of the soft tissues with a unique chromosomal translocation t(X;18)(p 11.2;q11.2) that can be detected by polymerase chain reaction in tissue homogenates. The case of a 32-year-old woman with a primary synovial sarcoma of the kidney is described, the diagnosis was corroborated by the recently developed method of in situ polymerase chain reaction (IS-PCR). Synovial sarcoma of the kidney may be confused with other spindle cell tumors, for that reason IS-PCR may be useful to confirm the diagnosis in paraffin-embedded material.
Gabilondo
Fernando
F
Instituto Nacional de Nutrición y Ciencias Médicas Salvador Zubirán, Mexico City, Mexico.
Rodríguez
Francisco
F
Mohar
Alejandro
A
Nuovo
Gerald J
GJ
Domínguez-Malagón
Hugo
H
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D007680:Kidney Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics; D009392:Nephrectomy; D015514:Oncogene Proteins, Fusion / Q000032:analysis; D016133:Polymerase Chain Reaction / Q000379:methods*; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000032:analysis; D013584:Sarcoma, Synovial / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic; D009396:Wilms Tumor / Q000175:diagnosis
D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C116512:SYT-SSX fusion protein