Sex dimorphism in the outcome of preoperative right portal vein embolization.
OBJECTIVE
Although studies indicate that patient sex modulates the process of hepatic regeneration, it remains unknown whether sex has a role in the outcome of preoperative right portal vein embolization (PVE). We analyzed the effects of patient sex on the outcome of right PVE followed by major hepatectomy.


METHODS
Retrospective study.


METHODS
Academic research.


METHODS
Eighty-eight patients (42 men and 46 women) who underwent preoperative right PVE for bile duct carcinoma were analyzed retrospectively.


METHODS
The percentage liver volume change, the plasma indocyanine green clearance rate, and the rate of postoperative hepatic failure were compared between men and women.


RESULTS
The mean (SD) volume of the nonembolized lobe after PVE in women (323 [61] mL/m(2)) was statistically significantly greater than that in men (287 [61] mL/m(2)) (P =.008). The mean (SD) ratio of the nonembolized lobe to the total liver volume was also statistically significantly greater in women (45.8% [5.8%]) than in men (42.0% [5.9%]) (P =.003). The mean (SD) indocyanine green clearance rate of the future liver remnant was 0.075 [0.014] in women and 0.056 [0.011] in men (P =.001). The incidence of postoperative hepatic failure was higher in men (12 of 42 [28.6%]) than in women (8 of 46 [17.4%]) (P =.16).


CONCLUSIONS
These results indicate that sex dimorphism can be present in the outcome of preoperative right PVE.
Yokoyama
Yukihiro
Y
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. yyoko@med.nagoya-u.ac.jp
Nagino
Masato
M
Oda
Koji
K
Nishio
Hideki
H
Ebata
Tomoki
T
Abe
Tetsuya
T
Igami
Tsuyoshi
T
Nimura
Yuji
Y
D000368:Aged; D001661:Biliary Tract Neoplasms / Q000601:surgery / Q000628:therapy*; D004396:Coloring Agents / Q000493:pharmacokinetics; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D017093:Liver Failure / Q000209:etiology; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011169:Portal Vein; D011300:Preoperative Care; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome
D004396:Coloring Agents; D007208:Indocyanine Green