The (pro)renin receptors.
Two (pro)renin receptors have been characterized so far, the mannose-6-phosphate receptor (M6P-R) and a specific receptor called (P)RR for (pro)renin receptor. Each receptor controls a different aspect of renin and prorenin metabolism. The M6P-R is a clearance receptor, whereas (P)RR mediates their cellular effects by activating intracellular signaling and up-regulating gene expression. Moreover, binding to (P)RR increases renin enzymatic activity and fully activates prorenin, the inactive proenzyme form of renin. Experimental models suggest that increased (P)RR synthesis and/or activation may be relevant to diseases, especially to high blood pressure, to cardiac fibrosis associated with hypertension, and to diabetic nephropathy.
Nguyen
Geneviève
G
INSERM Unit 833, Collège de France, 11 place Marcelin Berthelot, Paris, France. genevieve.nguyen@college-de-france.fr
Contrepas
Aurélie
A
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D012083:Renin / Q000378:metabolism; D000093342:Prorenin Receptor
D011956:Receptors, Cell Surface; D012083:Renin; D000093342:Prorenin Receptor