title: How I do it: surgical management of gastrointestinal stromal tumors.
abstract: The surgical management of gastrointestinal stromal tumors (GISTs) has been impacted by the development of tyrosine kinase inhibitors (TKIs), advances in surgical technique, and a better understanding of the natural history of this unique disease. In this article, we review the technical aspects of the operations, the expanding role of laparoscopy, and the indications for neoadjuvant and neoadjuvant TKI therapy in primary GIST. Furthermore, we explore the rationale for and incorporation of surgery in the multidisciplinary management of advanced GIST.
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA. craut@partners.org
authors.forename: Chandrajit P
authors.initials: CP
authors.lastname: Raut
authors.forename: Stanley W
authors.initials: SW
authors.lastname: Ashley
mesh_terms: D017024:Chemotherapy, Adjuvant; D013505:Digestive System Surgical Procedures / Q000379:methods* / Q000401:mortality; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D007813:Laparotomy / Q000009:adverse effects / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality; D011379:Prognosis; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D018570:Risk Assessment; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D047428:Protein Kinase Inhibitors