Trans-synaptic plasticity: presynaptic initiation, postsynaptic memory.
A novel mechanism of persistent facilitation induced by serotonin at Aplysia synapses depends upon rapid postsynaptic protein synthesis and increased responsiveness to glutamate; whereas the memory for this synaptic change is postsynaptic, the initiating signal may be an increase in spontaneous release of glutamate from the presynaptic terminals.
Wan
Qin
Q
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201-1559, USA.
Abrams
Thomas W
TW
D000818:Animals; D001048:Aplysia / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D009046:Motor Neurons / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
D012701:Serotonin; D018698:Glutamic Acid