Fiber-optic infrared reflection absorption spectroscopy for trace analysis on surfaces of varying roughness. Part II: Acetaminophen on stainless steel.
Investigations of the effects of surface roughness on the utility of grazing-angle Fourier transform infrared reflection absorption spectroscopy (IRRAS) as a method for quantifying trace contamination of metal surfaces have been extended to acetaminophen, a model active pharmaceutical agent, on 316 stainless steel. The effects are more complicated than for the surfactant sodium dodecyl sulfate (SDS) on stainless steel; they include a strong surface-finish dependence of sensitivity and nonlinear behavior at surface loadings above approximately 1-2 microg cm(-2). Using data from samples in the loading range 0-0.5 microg cm(-2), unbiased partial least squared calibrations can be readily achieved for individual surface finishes with detection limits of L(D) approximately 0.15 microg cm(-2). However, as found for SDS on stainless steel, models built using data from samples of mixed surface roughness are more problematic.
Perston
Benjamin B
BB
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Hamilton
Michelle L
ML
Harland
Peter W
PW
Thomson
Mary A
MA
Melling
Peter J
PJ
Williamson
Bryce E
BE
D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000032:analysis / Q000737:chemistry*; D003666:Decontamination; D005336:Fiber Optic Technology; D008855:Microscopy, Electron, Scanning; D055100:Optical Fibers; D012967:Sodium Dodecyl Sulfate / Q000032:analysis / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods; D013193:Stainless Steel / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000032:analysis / Q000737:chemistry
D018712:Analgesics, Non-Narcotic; D013501:Surface-Active Agents; D013193:Stainless Steel; D000082:Acetaminophen; D012967:Sodium Dodecyl Sulfate