title: [Case of HLA-DR8 positive sarcoidosis following polymyositis and Sjögren's syndrome].
abstract: A 69-year-old woman had been found to have idiopathic interstitial pneumonia (fibrotic NSIP) in 1997. Proximal muscle weakness appeared in April 2005. Chest CT revealed hilar and mediastinal lymphadenopathy. Polymyositis and Sjögren's syndrome were subsequently diagnosed. We assumed that the interstitial pneumonia had preceded polymyositis and Sjögren's syndrome. A muscle biopsy and transbronchial needle aspiration biopsy demonstrated noncaseating epithelioid cell granulomas. A diagnosis of sarcoidosis complicated with polymyositis and Sjögren's syndrome was made from these findings. Moreover, her HLA genotype contained DR8. HLA-DR8 is considered to be associated with polymyositis, Sjögren's syndrome, and sarcoidosis in Japanese patients. This case suggests the possibility that there are common immunological and genetical pathogenetic mechanisms in autoimmune diseases and sarcoidosis.
authors.affiliation: Department of Respiratory Medicine, Gunma University Medical School.
authors.forename: Zen
authors.initials: Z
authors.lastname: Isobe
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suga
authors.forename: Shigeto
authors.initials: S
authors.lastname: Hamaguchi
authors.forename: Shouzaburou
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Hara
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Aoki
authors.forename: Nozomi
authors.initials: N
authors.lastname: Aoki
authors.forename: Kana
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Manabu
authors.initials: M
authors.lastname: Ueno
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Maeno
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000368:Aged; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D059810:HLA-DR Serological Subtypes; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000235:genetics / Q000276:immunology; D017285:Polymyositis / Q000235:genetics / Q000276:immunology*; D012507:Sarcoidosis / Q000235:genetics / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology*
chemical_list: D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen