title: SF-6D versus EQ-5D: reasons for differences in utility scores and impact on reported cost-utility.
abstract: The choice of instrument (e.g. EQ-5D vs. SF-6D) can lead to different health-related utility scores, but it is unclear why these differences arise and whether they change cost utility analysis (CUA) results. This paper addresses these issues using a case study where using SF-6D rather EQ-5D led to greater utility gain and a lower cost per QALY for treatment. The paper examines reasons for this difference. This paper finds that an important factor was the inclusion in the SF-6D descriptive system of separate items for "vitality" and "social functioning", not explicitly included in EQ-5D. Further studies are required that examine the impact of the choice of instrument on cost-utility.
authors.affiliation: London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. richard.grieve@lshtm.ac.uk
authors.forename: Richard
authors.initials: R
authors.lastname: Grieve
authors.forename: Marina
authors.initials: M
authors.lastname: Grishchenko
authors.forename: John
authors.initials: J
authors.lastname: Cairns
mesh_terms: D000998:Antiviral Agents / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis / Q000379:methods; D017048:Health Care Costs; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000191:economics; D006801:Humans; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic
chemical_list: D000998:Antiviral Agents