Piggybacking schistosome invasion: similarities are only skin deep.
Schistosomes cause significant morbidity and mortality. In this article, we discuss recent findings regarding how different schistosome species infect and manipulate immune responses in their hosts through the evolution and use of different protease classes. The advent of transgenic schistosomes is explored in relation to the biology of these important molecules.
Pleass
Richard J
RJ
Institute of Genetics, Queens Medical Centre, Nottingham NG7 2UH, UK. richard.pleass@nottingham.ac.uk <richard.pleass@nottingham.ac.uk>
Aboobaker
A Aziz
AA
Schmitt
Armin O
AO
D000818:Animals; D019143:Evolution, Molecular; D006790:Host-Parasite Interactions / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D008967:Molecular Biology; D030781:Organisms, Genetically Modified; D010447:Peptide Hydrolases / Q000378:metabolism; D012547:Schistosoma / Q000201:enzymology / Q000472:pathogenicity*; D012552:Schistosomiasis / Q000469:parasitology* / Q000635:transmission; D012697:Serine Endopeptidases / Q000378:metabolism
D010447:Peptide Hydrolases; D012697:Serine Endopeptidases