Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine.
Thirty adults were tested for humoral and cellular immune responses following immunization with the trivalent inactivated influenza vaccine. Modest but significant inverse correlations between the baseline and the fold changes in the number of IFNgamma-producing cells and the levels of neutralizing antibodies were observed. Specific increases in proliferative responses in the CD8 CD45RA+ population were noted after vaccination. Minimal correlations between neutralizing antibody titers and the number of IFNgamma-producing cells in terms of prevaccination levels or fold increases were observed. These results show specific increases in a CD8 T cell subset and discordant T and B responses induced by the trivalent inactivated influenza vaccine.
Co
Mary Dawn T
MD
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, United States. mary.co@umassmed.edu
Orphin
Laura
L
Cruz
John
J
Pazoles
Pamela
P
Rothman
Alan L
AL
Ennis
Francis A
FA
Terajima
Masanori
M
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D016827:CD8 Antigens / Q000378:metabolism; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis; D017493:Leukocyte Common Antigens / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D009500:Neutralization Tests; D037182:T-Cell Antigen Receptor Specificity; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014611:Vaccination
D000914:Antibodies, Viral; D016827:CD8 Antigens; D007252:Influenza Vaccines; D007371:Interferon-gamma; D017493:Leukocyte Common Antigens