Facile one-pot synthesis of 5-substituted hydantoins.
5-Substituted and 5,5-disubstituted hydantoins are synthesised from the corresponding aldehydes or ketones, using a one-pot, gallium(III) triflate-catalysed procedure that is compatible with a range of substrates and solvents.
Murray
Ross G
RG
EaStCHEM, School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, UK.
Whitehead
David M
DM
Le Strat
Franck
F
Conway
Stuart J
SJ
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure
D000447:Aldehydes; D006827:Hydantoins; D007659:Ketones; D008698:Mesylates; C516572:gallium triflate