The HapMap: charting a course for genetic discovery in neurological diseases.
Whole-genome association analyses have begun to yield confirmed findings for genetic risk variants for complex disease. As the first reports of its application to neurological disease are described, we review this progress, explain the principles of the analysis, and discuss what the future is likely to be in this exciting area.
Hardy
John
J
Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, Queen Square, London WC1 3BG, England. j.hardy@ion.ucl.ac.uk
Singleton
Andrew
A
D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics*