Meclonazepam analogues as potential new antihelmintic agents.
New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni.
Mahajan
Aman
A
Department of Chemistry, University of Cape Town, Private Bag, Rondebosh-7701, South Africa.
Kumar
Vipan
V
Mansour
Nuha R N
NR
Bickle
Quentin
Q
Chibale
Kelly
K
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000138:chemical synthesis / Q000494:pharmacology*; D008956:Models, Chemical; D012550:Schistosoma mansoni / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D002998:Clonazepam / Q000031:analogs & derivatives
D000871:Anthelmintics; D001570:Benzodiazepinones; C020602:meclonazepam; D002998:Clonazepam