Factor V Leiden: is it the chief contributor to activated protein C resistance in Asian-Indian patients with deep vein thrombosis?
BACKGROUND
Deep vein thrombosis is a condition, which has several acquired as well as genetic causes. One of the most common reasons for deep vein thrombosis is activated protein C resistance caused by Factor V Leiden.


METHODS
We examined the risk posed by Factor V Leiden, Hong Kong/Cambridge and HR2 Haplotype mutations in 155 deep vein thrombosis patients and 120 healthy controls in the background of activated protein C resistance.


RESULTS
Thirty-one of our patients showed activated protein C resistance of which only 16 carried Factor V Leiden mutation which was a far lower number than what is usually seen in Caucasian population. Factor V Leiden mutation was significantly associated with the risk of deep vein thrombosis (Yates corrected p-value=0.002; 95%CI; odds ratio: 13.7). Factor V Hong Kong/Cambridge and HR2 Haplotype were not found to be associated with the risk of deep vein thrombosis. There is a possibility that Factor V HR2 Haplotype might also be associated with activated protein C resistance even in the absence of Factor V Leiden.


CONCLUSIONS
Factor V Leiden mutation was seen to contribute far less towards activated protein C resistance in Asian-Indian deep vein thrombosis patients than what has been commonly observed in Caucasians.
Biswas
Arijit
A
Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.
Bajaj
Jyoti
J
Ranjan
Ravi
R
Meena
Arvind
A
Akhter
Mohd Suhail
MS
Yadav
Birendra Kumar
BK
Sharma
Vinita
V
Saxena
Renu
R
D020016:Activated Protein C Resistance / Q000097:blood*; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006801:Humans; D007194:India; D008875:Middle Aged; D009154:Mutation; D020246:Venous Thrombosis / Q000097:blood* / Q000235:genetics*
C403771:factor V Hong Kong; C095381:factor V Leiden; D005165:Factor V