Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers.
Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement.
Sánchez-Vázquez
Rene
R
Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara, Guadalajara, Jalisco, Mexico.
Briseño-Rodríguez
G
G
Cardona-Muñoz
Ernesto German
EG
Gálvez-Gastélum
Francisco Javier
FJ
Totsuka-Sutto
Silvia Elena
SE
Garcia-Benavides
Leonel
L
D000279:Administration, Cutaneous; D000336:Aerosols; D002196:Capillaries / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D014665:Vasodilator Agents / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D000336:Aerosols; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate