title: Local delivery of chlorhexidine gluconate in patients with aggressive periodontitis.
abstract: The aim of this randomized, controlled, single-blinded trial was to evaluate the effectiveness of a biodegradable chlorhexidine chip as an adjunctive therapy to scaling and root planing. Eleven consecutive patients with aggressive periodontitis were recruited for this study. Each volunteer provided four sites with probing depth > or = 5 mm. Two sites received scaling and root planing (SRP) and placement of the chlorhexidine chip (PC), and the other two sites received scaling and root planing only. The clinical outcomes were measured at baseline, 6 weeks and 3 months after treatment. All patients completed the trial. None of the volunteers reported any adverse effect. Both groups showed a significant reduction in periodontal pocket depth (PPD) and gain in clinical attachment level (CAL) after treatment. However, there were no significant differences in the clinical parameters between the groups after 6 weeks and after 3 months. Sites presenting probing depths > or = 8 mm at baseline treated with SRP + PC demonstrated greater reduction in PPD and a greater CAL gain than sites treated with SRP alone after 6 weeks and after 3 months. The authors concluded that the adjunctive use of the biodegradable chlorhexidine chip resulted in greater reduction of PPD and additional gain in CAL in deep pockets (PPD > or = 8 mm) in patients with aggressive periodontitis when compared to scaling and root.
authors.affiliation: Department of Periodontology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Fabio de Freitas
authors.initials: Fde F
authors.lastname: Duarte
authors.forename: Roberto Fraga Moreira
authors.initials: RF
authors.lastname: Lotufo
authors.forename: Cláudio Mendes
authors.initials: CM
authors.lastname: Pannuti
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D010518:Periodontitis / Q000188:drug therapy*; D016037:Single-Blind Method; D018709:Statistics, Nonparametric
chemical_list: D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; C010882:chlorhexidine gluconate; D002710:Chlorhexidine