Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol.
1,3-Propanediol and 2,3-butanediol are two promising chemicals which have a wide range of applications and can be biologically produced. The separation of these diols from fermentation broth makes more than 50% of the total costs in their microbial production. This review summarizes the present state of methods studied for the recovery and purification of biologically produced diols, with particular emphasis on 1,3-propoanediol. Previous studies on the separation of 1,3-propanediol primarily include evaporation, distillation, membrane filtration, pervaporation, ion exchange chromatography, liquid-liquid extraction, and reactive extraction. Main methods for the recovery of 2,3-butanediol include steam stripping, pervaporation, and solvent extraction. No single method has proved to be simple and efficient, and improvements are especially needed with regard to yield, purity, and energy consumption. Perspectives for an improved downstream processing of biologically produced diols, especially 1,3-propanediol are discussed based on our own experience and recent work. It is argued that separation technologies such as aqueous two-phase extraction with short chain alcohols, pervaporation, reverse osmosis, and in situ extractive or pervaporative fermentations deserve more attention in the future.
Xiu
Zhi-Long
ZL
Department of Bioscience and Biotechnology, School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, PR China. zhlxiu@dlut.edu.cn
Zeng
An-Ping
AP
D001709:Biotechnology / Q000379:methods*; D002072:Butylene Glycols / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000378:metabolism; D002845:Chromatography; D005285:Fermentation; D005374:Filtration; D011409:Propylene Glycols / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000378:metabolism
D002072:Butylene Glycols; D011409:Propylene Glycols; C026978:2,3-butylene glycol; C041787:1,3-propanediol