title: Feasibility of the sentinel node biopsy in anal cancer.
abstract: OBJECTIVE
  Anal cancer is a rare neoplasm. According to a European Organization for Research and Treatment of Cancer multivariate analysis, synchronous inguinal lymph node metastasis occurs in 10-25% of patients and constitutes an independent prognostic factor for local failure and overall mortality.
  
  
  METHODS
  Inguinal lymph node status was assessed using the sentinel node technique in 35 patients with anal cancer.
  
  
  RESULTS
  Histology revealed 23 squamous carcinomas, 10 basaloid carcinomas, 1 squamous carcinoma with basaloid areas and 1 spinocellular epithelioma associated with areas of Bowen's disease. Disease stage was T1 in 5 patients, T2 in 18, T3 in 11 and T4 in 1 patient. Lympho-scintigraphy using a GE Millennium gamma camera was performed after peritumoral injection of 37 MBq of 99mTc colloid. Surgical sentinel node biopsy with a portable Scintiprobe MR 100 (Politech, Carsoli, Italy) had a detection rate of 97.1%. Inguinal metastases were detected in 7 (20%) patients, in 2 of which metastasis was bilateral.
  
  
  CONCLUSIONS
  Given the correlation between prognosis and node involvement, sentinel node biopsy can be considered a simple method for adequate pretreatment staging of anal carcinoma. Use of the technique could avert the need for prophylactic inguinal radiotherapy in N0-N1 patients, thus reducing the morbidity associated with inguinal radiotherapy. Consistent follow-up is required to evaluate long-term results:
authors.affiliation: Surgical and Oncological Department, University of Turin, Molinette Hospital, Turin, Italy. mistrangelo@katamail.com
authors.forename: M
authors.initials: M
authors.lastname: Mistrangelo
authors.forename: M
authors.initials: M
authors.lastname: Bellò
authors.forename: A
authors.initials: A
authors.lastname: Mobiglia
authors.forename: G
authors.initials: G
authors.lastname: Beltramo
authors.forename: P
authors.initials: P
authors.lastname: Cassoni
authors.forename: E
authors.initials: E
authors.lastname: Milanesi
authors.forename: S
authors.initials: S
authors.lastname: Cornaglia
authors.forename: E
authors.initials: E
authors.lastname: Pelosi
authors.forename: F
authors.initials: F
authors.lastname: Giunta
authors.forename: S
authors.initials: S
authors.lastname: Sandrucci
authors.forename: A
authors.initials: A
authors.lastname: Mussa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007264:Inguinal Canal / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D012008:Recurrence; D021701:Sentinel Lymph Node Biopsy