Kinesin-driven transport in cell-free environment.
Conventional kinesin is an ATPase-active motor protein that is involved in the microtubule-dependent transport of cytoplasmic cargoes. The present paper provides a condensed overview on kinesin-1 and its motility generation outside a living cell. Moreover, it demonstrates that the neuron-specific kinesin KIF5A enables the formation of microtubules under conditions where pure tubulin does not assemble.
Böhm
Konrad J
KJ
Leibniz Institute for Age Research, Fritz Lipmann Institute, Molecular Motors Lab, Beutenbergstrasse 11, D-07745 Jena, Germany. kboehm@fli-leibniz.de
D000818:Animals; D002474:Cell-Free System; D016547:Kinesins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D021381:Protein Transport
D016547:Kinesins