title: Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype.
abstract: OBJECTIVE
  The anti-tumoral activity of bisphosphonates (BPs) has been reported in leukemia. In this study, we attempted to evaluate the apoptotic effects of the BPs pamidronate (PAM) and zoledronic acid (ZOL) in chronic lymphocytic leukemia (CLL) samples, and to correlate it with clinical parameters and multidrug resistance (MDR) phenotype (P-glycoprotein and multidrug resistance-related protein expression and/or their functional activity).
  
  
  RESULTS
  Both BPs were able to induce apoptosis significantly. No correlation was observed between BP-induced apoptosis and clinical parameters or MDR phenotype.
  
  
  CONCLUSIONS
  Our data suggest that concurrent or sequential administration of BPs with conventional chemotherapeutic drugs may have significant therapeutic potential for CLL patients.
authors.affiliation: Laboratório de Hematologia Celular e Molecular, Serviço de Hematologia, Hospital do Câncer I, Instituto Nacional de Câncer, Praça Cruz Vermelha 23, 6 andar, Centro, Rio de Janeiro, RJ, CEP. 20230-130, Brazil.
authors.forename: Karina Lani
authors.initials: KL
authors.lastname: Silva
authors.forename: Deborah Vidal
authors.initials: DV
authors.lastname: Vasconcellos
authors.forename: Eric Delfraro de Paula
authors.initials: ED
authors.lastname: Castro
authors.forename: Flavia da Cunha
authors.initials: FC
authors.lastname: Vasconcelos
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bigni
authors.forename: Raquel Ciuvalschi
authors.initials: RC
authors.lastname: Maia
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004164:Diphosphonates / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D005434:Flow Cytometry; D019450:Genes, MDR / Q000235:genetics*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000077268:Pamidronate; D010641:Phenotype; D000077211:Zoledronic Acid
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000077268:Pamidronate