Multitasking of interferon regulatory factor-4 in early B cells.
Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling.
Nielsen
Peter
P
Max Planck Institute of Immunobiology, Freiburg, Germany.
Grosschedl
Rudolf
R
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain / Q000276:immunology*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000276:immunology* / Q000378:metabolism; D015851:Interleukin-7 / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013234:Stem Cells / Q000166:cytology* / Q000276:immunology; D000099218:Interferon Regulatory Factor-4
D050835:Interferon Regulatory Factors; D015851:Interleukin-7; D000099218:Interferon Regulatory Factor-4