title: Agammaglobulinemia and Staphylococcus aureus botryomycosis in a cohort of related sentinel Swiss Webster mice.
abstract: Sentinel mouse seroconversion to infectious agents is critical for laboratory animal facility disease monitoring. We report spontaneous emergence of non-sex-linked agammaglobulinemia with B-cell deficiency and cutaneous Staphylococcus aureus granulomatosis (botryomycosis) in a cohort of related Swiss Webster sentinel mice. Our experience reinforces the importance of immunocompetency validation in surveillance programs.
authors.affiliation: Division of Comparative Medicine 16-825, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ecbridge@mit.edu
authors.forename: Erin C
authors.initials: EC
authors.lastname: Bridgeford
authors.forename: James G
authors.initials: JG
authors.lastname: Fox
authors.forename: Prashant R
authors.initials: PR
authors.lastname: Nambiar
authors.forename: Arlin B
authors.initials: AB
authors.lastname: Rogers
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D051379:Mice; D018571:Sentinel Surveillance; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013207:Staphylococcal Skin Infections / Q000276:immunology* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification*