Extensive chromoblastomycosis caused by Fonsecaea pedrosoi successfully treated with a combination of amphotericin B and itraconazole.
Chromoblastomycosis is a chronic infection caused by dematiaceous (dark-colored) fungi which affect the skin and subcutaneous tissues, and is characterized by a wide variety of clinical and dermatological features including papillomatous, verrucous and vegetating lesions. Although it has been described world-wide, most cases originate in tropical and sub-tropical areas. In general, present treatments of the disease are unsatisfactory as one of the most common etiologic agents, Fonsecaea pedrosoi is difficult to manage from a therapeutic point of view. We report a case of extensive chromoblastomycosis of 22 years duration caused by F. pedrosoi and review the clinical course, diagnosis and management of this disease.
Paniz-Mondolfi
A-E
AE
Laboratorio de Estudio de Antígenos, Instituto de Biomedicina/Hospital 'José Gregorio Hernández', Instituto Venezolano de los Seguros Sociales.
Colella
M-T
MT
Negrín
D-C
DC
Aranzazu
N
N
Oliver
M
M
Reyes-Jaimes
O
O
Pérez-Alvarez
A-M
AM
D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001203:Ascomycota / Q000302:isolation & purification / Q000472:pathogenicity*; D002862:Chromoblastomycosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D003904:Mitosporic Fungi
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B