title: RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease.
abstract: This review focuses on the current findings regarding interaction between amyloid beta peptide (Abeta) and receptor for advanced glycation endproducts (RAGE) and its roles in the pathogenesis of Alzheimer's disease (AD). As a ubiquitously expressed cell surface receptor, RAGE mediates the effects of Abeta on microglia, blood-brain barrier (BBB) and neurons through activating different signaling pathways. Data from autopsy brain tissues, in vitro cell cultures and transgenic mouse models suggest that Abeta-RAGE interaction exaggerates neuronal stress, accumulation of Abeta, impaired learning memory, and neuroinflammation. Blockade of RAGE protects against Abeta-mediated cellular perturbation. These findings may have an important therapeutic implication for neurodegenerative disorders relevant to AD.
authors.affiliation: Department of Neurology and Neurosurgery,North Shore-LIJ Health System, NY, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Walker
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Ottavio
authors.initials: O
authors.lastname: Arancio
authors.forename: Lih-Fen
authors.initials: LF
authors.lastname: Lue
authors.forename: Shi Du
authors.initials: SD
authors.lastname: Yan
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D011485:Protein Binding; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D013569:Synapses / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic