title: Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy?
abstract: OBJECTIVE
  To review the literature on biopsy of lacrimal gland pleomorphic adenoma (LGPA) and to examine the validity of the prohibition against biopsy in LGPA.
  
  
  METHODS
  Literature review.
  
  
  RESULTS
  LGPA is usually diagnosed preoperatively based on clinical and radiological characteristics, as current teaching advises complete excision without prior incisional biopsy. The caveat against biopsy is based on older studies that reported increased recurrence rates with increased risk of malignant transformation after incomplete excision or biopsy. On the basis of a detailed examination of the literature on biopsy of both LGPA and pleomorphic adenoma of the salivary glands, it appears that there is no clear evidence to support the claim that biopsy increases the risk of recurrence or of malignant transformation of LGPA.
  
  
  CONCLUSIONS
  Lacrimal gland tumours are uncommon lesions and optimal management depends to a great extent on a definite preoperative diagnosis. Preoperative biopsy should therefore be considered in all lacrimal gland mass lesions and management should be tailored to the biopsy findings. If surgical resection is then required, it may be prudent to excise the biopsy tract to ensure complete removal of the tumour.
authors.affiliation: Department of Ophthalmology & Visual Sciences, South Australian Institute of Ophthalmology, University of Adelaide, South Australia, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Lai
authors.forename: V C
authors.initials: VC
authors.lastname: Prabhakaran
authors.forename: R
authors.initials: R
authors.lastname: Malhotra
authors.forename: D
authors.initials: D
authors.lastname: Selva
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D001706:Biopsy; D005134:Eye Neoplasms / Q000473:pathology*; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology*; D007766:Lacrimal Apparatus Diseases / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology