Zinc-catalyzed silylation of terminal alkynes.
A rapid and high-yielding silylation of terminal alkynes employing TMSOTf and catalytic quantities of Zn(OTf)2 has been developed. The reaction works well for a variety of substrates including reactive esters. Fifteen examples with yields of >90% are reported.
Rahaim
Ronald J
RJ
Broad Institute of Harvard and MIT Program in Chemical Biology, 7 Cambridge Center, Cambridge, MA 02142, USA.
Shaw
Jared T
JT
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D000480:Alkynes; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D015032:Zinc