Comparative antiviral (HIV) photoactivity of metalized meso- tetraphenylsulfonated porphyrins.
We have carried out the study of the photochemical properties of a series of synthetic meso-tetraphenylsulfonated porphyrins (TPPMS4) bonded to several metal ions such as: Cu(II), Zn(II), Pd(II), Mn(II), Fe(III), Ni(II) and Co(II) for the optimization of their clinical applications as antiviral agents against the human immunodeficiency virus (HIV-1) as well as the study of the in vitro antiviral photoinactivation mechanisms with future application in blood sterilization. A selective inhibition has been determined in the viral growth (HIV-1) when this is irradiated in the presence of the complex TPPFeS4 and TPPMnS4 (photosensitizer-mediated Type I reaction) as well as in the 1O2-mediated (Type II reaction) in the presence of TPPPdS4 and TPPZnS4, remaining cellular viability unaltered in each case.
Vargas
Franklin
F
Laboratorio de Fotoquímica, Centro de Química, Instituto Venezolano de Investigaciones Cientificas I.V.I.C., Caracas 1020-A, Venezuela. fvargas@ivic.ve
Rivas
Carlos
C
Zoltan
Tamara
T
Padrón
Liliana
L
Izzo
Carla
C
López
Verónica
V
Gómez
Lubimar
L
Pujol
Flor
F
Rangel
Hector
H
Garzaro
Domingo
D
Fabbro
Rona
R
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival; D015497:HIV-1 / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D019216:Metals, Heavy; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D013242:Sterilization / Q000379:methods*
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D008665:Metalloporphyrins; D019216:Metals, Heavy; D017319:Photosensitizing Agents