[Investigation of Coptis chinensis on jaundice of glucose-6-phosphate dehydrogenase (G6PD) deficient neonates from Guigang, Guangxi province].
OBJECTIVE
To investigate the effect of Coptis chinensis on jaundice of G6PD deficient neonates.


METHODS
122 G6PD deficient neonates with jaundice who were in People' s Hospital of Guigang of Guangxi province from January 1999 to October 2004 were divided into two groups: C. chinensis group (62 neonates with C. chinensis administration before jaundice' s appearance) and none C. chinensis group (60 neonates without C. chinensis administration before jaundice' s appearance). The initial time, duration of jaundice, hemoglobin and serum bilirubin level and the incidence of kernicterus were analyzed between the two groups.


RESULTS
The initial time of jaundice is significantly later and the duration of jaundice is markedly shorter in the neonates with C. chinensis than that without C. chinensis. Simultaneously, the level of hemoglobin is significantly increased, and there is a low tendency of serum total bilirubin and direct bilirubin level in C. chinensis group as compared to that in none C. chinensis group. Moreover, there is no kernicterus in C. chinensis group and no difference in the treating result out of hospital between the two groups.


CONCLUSIONS
Our results do not support the view that C. chinensis could aggravate jaundice of G6PD deficient neonates.
Lin
Xiu-Lan
XL
People's Hospital of Guigang, Guigang 537100, China.
Lin
Na
N
Liu
Chun-Fang
CF
Liu
Yuan
Y
Liang
Zhi-Ran
ZR
Wan
Rong
R
Kong
Xiang-Ying
XY
D001663:Bilirubin / Q000097:blood; D002681:China; D039323:Coptis / Q000737:chemistry*; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000139:chemically induced / Q000150:complications; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood* / Q000139:chemically induced / Q000150:complications; D007647:Kernicterus / Q000097:blood / Q000139:chemically induced / Q000150:complications; D008297:Male; D028321:Plant Preparations / Q000009:adverse effects*; D010946:Plants, Medicinal / Q000737:chemistry; D012189:Retrospective Studies; D013997:Time Factors
D006454:Hemoglobins; D028321:Plant Preparations; D001663:Bilirubin