Correlation between clinical/neurophysiological findings and quality of life in Charcot-Marie-Tooth type 1A.
Quality of life (QoL), as defined by the Short Form 36, has previously been shown to be abnormal in patients with Charcot-Marie-Tooth disease (CMT), both for Physical Composite Scores (PCS) and Mental Composite Scores (MCS). We have now extended these observations in a multicenter evaluation of 89 patients with Charcot-Marie-Tooth disease type 1A, the most common form of CMT. Both the PCS and MCS were abnormal also in this cohort, compared with the Italian population at large. In particular, the ability to ambulate independently as well as toe and heel walk correlated well with QoL measures in our patients.
Padua
Luca
L
Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy. lpadua@rm.unicatt.it
Shy
Michael E
ME
Aprile
Irene
I
Cavallaro
Tiziana
T
Pareyson
Davide
D
Quattrone
Aldo
A
Rizzuto
Nicolo
N
Vita
Giuseppe
G
Tonali
Pietro
P
Schenone
Angelo
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D002607:Charcot-Marie-Tooth Disease / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology*; D015331:Cohort Studies; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*