[Inflammatory reactions in patients suffering from coronary artery disease with concomitant obesity and type 2 diabetes mellitus].
Of late, inflammatory reactions have been considered to play an important part in the development of atherosclerosis. Acute-phase inflammatory reaction, being initially a protective response directed within the homeostasis system towards lesion repair, may by itself due to various factors favor the development of pathological processes. Considering the role played by inflammation in the development of atherosclerosis, and inflammatory activity in obesity and diabetes mellitus (DM), a range of common and interrelated elements of these processes may be marked out. These are acute phase proteins and cytokines. Insulinoresistance, being the common precursor of obesity and DM, plays the key role in vascular lesion. The use of cytokine activity index seems to be a promising method of revealing patients with high risk of atherosclerosis.
Chukaeva
I I
II
Orlova
N V
NV
Aleshkin
V A
VA
Pukhal'skiĭ
A L
AL
Alekseeva
E G
EG
Gorina
O N
ON
Shmarina
G V
GV
Zakharova
O V
OV
D000368:Aged; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma