title: Comparison of pro B-natriuretic peptide in hypertensive patients with and without diastolic dysfunction.
abstract: OBJECTIVE
  to evaluate whether pro BNP can be used for detection of diastolic dysfunction.
  
  
  METHODS
  thirty nine hypertensive patients with normal systolic function, consecutively referred for echocardiography examination between October and December 2004 were recruited in the study. Diastolic dysfunction was diagnosed when echocardiographic mitral flow pattern demonstrated impaired relaxation, pseudonormalization or restrictive like patterns. NT-pro BNP levels were assessed using electro chemiluminescence Immunoassay (ECLIA) method. Unpaired t test was used to analyze the results.
  
  
  RESULTS
  twelve out of thirty nine subjects had normal diastolic function. All base line characteristics, except for uric acid, were equally distributed between normal and abnormal diastolic function group. NT-pro BNP levels were nearly significantly higher in the diastolic dysfunction group (P=0.053).
  
  
  CONCLUSIONS
  NT-pro BNP levels trends to be higher in hypertensive subjects with diastolic dysfunction.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine Atmajaya University, Jl. Pluit Raya no. 2, Jakarta. yudipsan@yahoo.com
authors.forename: Yudistira P
authors.initials: YP
authors.lastname: Santosa
authors.forename: Anna
authors.initials: A
authors.lastname: Tjandrawati
authors.lastname: Noormartany
authors.lastname: Erwinanto
authors.forename: Ahmad F
authors.initials: AF
authors.lastname: Yahya
authors.forename: Erwan
authors.initials: E
authors.lastname: Martanto
authors.forename: Pintoko
authors.initials: P
authors.lastname: Tedjokusumo
authors.forename: Augustine
authors.initials: A
authors.lastname: Purnomowati
authors.forename: Eko
authors.initials: E
authors.lastname: Antono
mesh_terms: D003971:Diastole / Q000502:physiology*; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain