title: Effect of vitamin E and selenium supplementation on oxidative stress status in pulmonary tuberculosis patients.
abstract: OBJECTIVE
  Increased production of reactive oxygen species secondary to phagocyte respiratory burst occurs in pulmonary tuberculosis (TB). The present study evaluated the efficacy of vitamin E-selenium supplementation on oxidative stress in newly diagnosed patients treated for pulmonary TB.
  
  
  METHODS
  A double-blind, placebo-controlled trial including patients with newly diagnosed TB was conducted. The intervention group (n = 17) received vitamin E and selenium (vitamin E: 140 mg alpha-tocopherol and selenium: 200 microg) and the control group (n = 18) received placebo. Both groups received standard anti-TB treatment. Assessment of micronutrient levels, oxidative markers and total antioxidant capacity were carried out at baseline and 2 months after the intervention.
  
  
  RESULTS
  Malondialdehyde levels were significantly reduced in the intervention group (P = 0.01), while there was minimal reduction in the control group. The mean plasma level of total antioxidants was increased significantly (P = 0.001) in both the intervention and the control groups.
  
  
  CONCLUSIONS
  A 2-month intervention with vitamin E and selenium supplementation reduces oxidative stress and enhances total antioxidant status in patients with pulmonary TB treated with standard chemotherapy.
authors.affiliation: Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz Azarbayegan Shargi, Iran. esrz80@yahoo.com
authors.forename: Ensiyeh
authors.initials: E
authors.lastname: Seyedrezazadeh
authors.forename: Alireza
authors.initials: A
authors.lastname: Ostadrahimi
authors.forename: Soltanali
authors.initials: S
authors.lastname: Mahboob
authors.forename: Yagoob
authors.initials: Y
authors.lastname: Assadi
authors.forename: Jamal
authors.initials: J
authors.lastname: Ghaemmagami
authors.forename: Masood
authors.initials: M
authors.lastname: Pourmogaddam
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D000995:Antitubercular Agents / Q000008:administration & dosage; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012643:Selenium / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D014810:Vitamin E; D008315:Malondialdehyde; D012643:Selenium