title: Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity.
abstract: Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard (DCMU). The structure-activity relationships are discussed.
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, 40006 Katowice, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Musiol
authors.forename: Dominik
authors.initials: D
authors.lastname: Tabak
authors.forename: Halina
authors.initials: H
authors.lastname: Niedbala
authors.forename: Barbara
authors.initials: B
authors.lastname: Podeszwa
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
authors.forename: Katarina
authors.initials: K
authors.lastname: Kralova
authors.forename: Jiri
authors.initials: J
authors.lastname: Dohnal
authors.forename: Jacek
authors.initials: J
authors.lastname: Finster
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mencel
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
mesh_terms: D000577:Amides / Q000737:chemistry*; D048408:Chlorella vulgaris / Q000187:drug effects / Q000378:metabolism; D002734:Chlorophyll / Q000378:metabolism; D002736:Chloroplasts / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000737:chemistry; D015394:Molecular Structure; D010788:Photosynthesis; D018724:Spinacia oleracea / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D006912:Hydroxyquinolines; D008055:Lipids; D002734:Chlorophyll