Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study.
Using the British Columbia Linked Health Databases, we explored the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of developing Parkinson's disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. A time-dependent Cox model was used to estimate adjusted rate ratios for users and non-users of NSAIDs. The results of our study did not show a protective effect of NSAIDs for PD (rate ratio 0.84, 95% CI 0.81-1.09).
Etminan
Mahyar
M
Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Carleton
Bruce C
BC
Samii
Ali
A
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001955:British Columbia / Q000453:epidemiology; D002170:Canada; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk
D000894:Anti-Inflammatory Agents, Non-Steroidal