title: Novel fluorescent pH sensor based on coumarin with piperazine and imidazole substituents.
abstract: A new coumarin derivative containing piperazine and imidazole moieties is reported as a fluorophore for hydrogen ions sensing. The fluorescence enhancement of the studied sensor with an increase in hydrogen ions concentration is based on the hindering of photoinduced electron transfer from the piperazinyl amine and the imidazolyl amine to the coumarin fluorophore by protonation. The presented sensor has a novel design of fluorophore-spacer-receptor(1)-receptor(2) format, which is proposed to sense two ranges of pH (from 2.5 to 5.5) and (from 10 to 12) instead of sensing one pH range. A model compound, in which the piperazinyl ring is absent, was synthesized as well to confirm the novel pH sensing of the proposed sensor.
authors.affiliation: Department of Chemistry, Yarmouk University, 21163 Irbid, Jordan. nsaleh@yu.edu.jo
authors.forename: Na'il
authors.initials: N
authors.lastname: Saleh
authors.forename: Yaseen A
authors.initials: YA
authors.lastname: Al-Soud
authors.forename: Werner M
authors.initials: WM
authors.lastname: Nau
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010777:Photochemistry; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D007093:Imidazoles; D010879:Piperazines