Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.
Schmidt
Marco Florian
MF
Leibniz Institute for Molecular Pharmacology, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.
Isidro-Llobet
Albert
A
Lisurek
Michael
M
El-Dahshan
Adeeb
A
Tan
Jinzhi
J
Hilgenfeld
Rolf
R
Rademann
Jörg
J
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D017934:Coronavirus / Q000201:enzymology; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008024:Ligands; D008026:Ligation; D010447:Peptide Hydrolases; D011480:Protease Inhibitors / Q000737:chemistry*
D008024:Ligands; D011480:Protease Inhibitors; D010447:Peptide Hydrolases