title: Spinal cord stimulation affects T-wave alternans in patients with ischaemic cardiomyopathy: a pilot study.
abstract: OBJECTIVE
  An antiarrhythmic effect of spinal cord stimulation (SCS) has been recognized in an animal model. The actual mechanism is still mainly unknown. An adrenergic output reduction has been advocated as the main mechanism, although a modulation effect on the arrhythmic substrate has not yet been investigated. We studied T-wave alternans (TWA) modifications to test the hypothesis that SCS affects the arrhythmic substrate.
  
  
  RESULTS
  We performed TWA assessment in three high-risk patients who previously had undergone implantation of both implantable cardioverter defibrillator and SCS to treat refractory angina. The test was performed after switching off the SCS and after 2 and 24 h stimulation at the default amplitude. The protocol was executed 2 months apart in order to assess the reproducibility of the results, collecting a total of 18 TWA reports. In all the three patients, we observed a significant reduction of TWA amplitude after 2 h stimulation. All the tests were classified as negative after 24 h stimulation with the nominal parameters.
  
  
  CONCLUSIONS
  Spinal cord stimulation results in a decrease in the TWA magnitude, and thus it seems to positively affect the arrhythmic substrate in a time-dependent manner.
authors.affiliation: UOADU Cardiology San Giovanni Battista, Corso Bramante 88, Turin 10100, Italy. ferpaolo77@libero.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferrero
authors.forename: Davide
authors.initials: D
authors.lastname: Castagno
authors.forename: Riccardo
authors.initials: R
authors.lastname: Massa
authors.forename: Anna
authors.initials: A
authors.lastname: De Luca
authors.forename: Maddalena
authors.initials: M
authors.lastname: Castellano
authors.forename: Claudio
authors.initials: C
authors.lastname: Chirio
authors.forename: Roberto
authors.initials: R
authors.lastname: Grimaldi
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000628:therapy; D009202:Cardiomyopathies / Q000503:physiopathology / Q000628:therapy*; D004599:Electric Stimulation Therapy / Q000379:methods*; D004562:Electrocardiography; D006329:Heart Conduction System / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy*; D010865:Pilot Projects; D013116:Spinal Cord / Q000502:physiology*; D013997:Time Factors