A descriptive evaluation of warfarin use in patients receiving hospice or palliative care services.
OBJECTIVE
To describe and compare warfarin therapy use and outcomes between warfarin-receiving patients in hospice or palliative care (HPC) and not in HPC.


METHODS
This retrospective, matched analysis examined warfarin-receiving patients who did (study cohort) and did not receive (control cohort) HPC services between 2002 and 2005. The matched cohorts were compared on rates of international normalized ratio (INR) measurements, INR control, and warfarin-related adverse events.


RESULTS
Included were 101 and 484 study and matched control patients, respectively. Study patients had a higher mean rate of INR measurements per 30 days (2.2 +/- 1.7 vs. 1.7 +/- 1.4, P = 0.001) and were more likely to be above and below target INR range (P < 0.05) than control patients. Differences between the cohorts in incidences of warfarin-related adverse events were not statistically significant (P > 0.05).


CONCLUSIONS
Patients in HPC required more frequent INR monitoring but had similar risks for warfarin-related adverse events.
Hill
Robin R
RR
Department of Pharmacy, Kaiser Permanente, Aurora, CO 80014, USA. Robin.R.Hill@kp.org
Martinez
Kerri D
KD
Delate
Thomas
T
Witt
Daniel M
DM
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D004341:Drug Evaluation; D005260:Female; D006738:Hospices; D006801:Humans; D019934:International Normalized Ratio; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D012189:Retrospective Studies; D016896:Treatment Outcome; D014859:Warfarin / Q000009:adverse effects / Q000627:therapeutic use*
D014859:Warfarin