title: Inhibitory feature of the proprotein convertases prosegments.
abstract: The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
authors.affiliation: INSERM U 716, Equipe AVENIR, Laboratoire de Pharmacologie Expérimentale et Clinique, Institut de Génétique Moléculaire, Paris ,75010, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Bontemps
authors.forename: Marion
authors.initials: M
authors.lastname: Lapierre
authors.forename: Geraldine
authors.initials: G
authors.lastname: Siegfried
authors.forename: Fabien
authors.initials: F
authors.lastname: Calvo
authors.forename: Abdel-Majid
authors.initials: AM
authors.lastname: Khatib
mesh_terms: D000595:Amino Acid Sequence; D010446:Peptide Fragments / Q000494:pharmacology; D043484:Proprotein Convertases / Q000737:chemistry / Q000494:pharmacology*; D017434:Protein Structure, Tertiary
chemical_list: D010446:Peptide Fragments; D043484:Proprotein Convertases