title: [Socio-demographic, lifestyle, gynecological, and obstetric predictors of serum or plasma concentrations of homocysteine, folic acid, and vitamins B12 and B6 among low-income women in São Paulo, Brazil].
abstract: This study examined the socio-demographic, lifestyle, gynecological, and obstetric factors associated with serum or plasma concentrations of homocysteine, folic acid, and vitamins B12 and B6 among low-income women in São Paulo, Brazil. Serum concentrations of folic acid and vitamin B12 were measured by fluoroimmunoassay, while plasma vitamin B6 and homocysteine levels were measured by reversed-phase high performance liquid chromatography. Independent variables were initially selected by Pearson correlation or Kruskal-Wallis test (p < 0.20). Based on cut-off values, altered concentrations of homocysteine, folic acid, and vitamins B12 and B6 were found in 20%, 6%, 11%, and 67% of participants, respectively. Age was positively correlated with vitamin B6 and homocysteine plasma concentrations (p < 0.001). Body mass index was positively correlated with vitamin B6 plasma concentration (p < 0.001). Multiple linear regression models accounted for 10.2%, 5.8%, 14.4%, and 9.4% of folic acid, vitamins B12 and B6, and homocysteine plasma or serum concentrations, respectively. In this study, socio-demographic, lifestyle, gynecological, and obstetric variables showed important predictive value for serum or plasma levels of the biochemical indicators assessed.
authors.affiliation: Faculdade de Saúde Pública, Universidade de São Paulo, Sço Paulo, Brasil.
authors.forename: Lana Carneiro
authors.initials: LC
authors.lastname: Almeida
authors.forename: Luciana Yuki
authors.initials: LY
authors.lastname: Tomita
authors.forename: Vânia
authors.initials: V
authors.lastname: D'Almeida
authors.forename: Marly Augusto
authors.initials: MA
authors.lastname: Cardoso
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D005260:Female; D015200:Fluoroimmunoassay; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009752:Nutritional Status; D011203:Poverty; D017584:Reproductive History; D012959:Socioeconomic Factors; D014803:Vitamin B Complex / Q000097:blood*; D014932:Women's Health Services; D055815:Young Adult
chemical_list: D006710:Homocysteine; D014803:Vitamin B Complex; D005492:Folic Acid