Guest aggregation within poly(L-lactic acid)/pluronic P104 thin films.
Rhodamine 6G (R6G) doped thin films composed of poly(L-lactic acid) (PLLA) and Pluronic P104 were spin cast onto glass microscope slides and characterized by ultraviolet-visible, steady-state, and time-resolved fluorescence spectroscopy. The results show that R6G aggregation within the film increases as the R6G concentration and P104 loading increases. These results suggest an approach for studying drug distributions (monomers, aggregates) within biodegradable polymer formulations.
Steves
Jordan M
JM
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Tan
Loraine T
LT
Gardella
Joseph A
JA
Hard
Robert
R
Hicks
Wesley L
WL
Cartwright
Alexander N
AN
Koc
Bahattan
B
Bright
Frank V
FV
D000042:Absorption; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D020442:Poloxamer / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods
D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D012235:Rhodamines; C026188:rhodamine 6G; D020442:Poloxamer; D019344:Lactic Acid; C033616:poly(lactide)