Infectious complications associated with immunomodulating monoclonal antibodies used in the treatment of hematologic malignancy.
Immunomodulating monoclonal antibodies are a relatively new addition to the armamentarium of cancer therapeutics and have been shown to improve clinical outcomes in patients with various hematologic malignancies. Because of their targeted nature, these agents are often believed to be less immunosuppressive than standard cytotoxic chemotherapeutic agents. A clear causal association between an immunomodulating therapy and its infectious sequelae is often difficult to discern because of the burden of comorbid illness, intrinsic immunosuppression from the underlying malignancy, use in the salvage setting, and prior and concomitant use of immunosuppressive agents in this patient population. This article evaluates better-established and anecdotal infectious complications associated with major immunomodulating therapies used in hematologic malignancy and hematopoietic stem cell transplantation, including rituximab, alemtuzumab, gemtuzumab ozogamicin, infliximab, dacluzimab, and basiliximab.
Koo
Sophia
S
Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA 02115, USA. skoo@partners.org
Baden
Lindsey R
LR
D000074323:Alemtuzumab; D000617:Aminoglycosides / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D058846:Antibodies, Monoclonal, Murine-Derived; D000912:Antibodies, Neoplasm / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000077552:Basiliximab; D003141:Communicable Diseases / Q000139:chemically induced* / Q000276:immunology; D000079982:Gemtuzumab; D006086:Graft vs Host Disease / Q000188:drug therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D000069285:Infliximab; D007938:Leukemia / Q000188:drug therapy*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000139:chemically induced / Q000276:immunology; D000069283:Rituximab; D033581:Stem Cell Transplantation; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000617:Aminoglycosides; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D058846:Antibodies, Monoclonal, Murine-Derived; D000912:Antibodies, Neoplasm; D000970:Antineoplastic Agents; D011993:Recombinant Fusion Proteins; D014409:Tumor Necrosis Factor-alpha; D000074323:Alemtuzumab; D000069283:Rituximab; D000079982:Gemtuzumab; D000077552:Basiliximab; D000069285:Infliximab