Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds.
Probucol is a diphenolic compound with anti-oxidant and anti-inflammatory properties that reduces atherosclerosis and restenosis. Unfortunately, adverse effects on blood lipoproteins and cardiac electrophysiology have curtailed its use as a drug. Compounds related to probucol that have improved efficacy without the adverse effects offer promise as novel therapies of cardiovascular disease. Recent results suggest that these compounds may be used for the prevention of type 2 diabetes, a disease that is increasing in prevalence and importance world-wide. In this review, the molecular mechanisms underlying the beneficial activities of probucol and related compounds are described.
Tanous
David
D
Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, Toronto, Canada.
Hime
Neil
N
Stocker
Roland
R
D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D011341:Probucol / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D011341:Probucol