Pharmacogenetics and obstetric anesthesia.
The ultimate goal of pharmacogenetics research is to help doctors tailor doses of medicines to a person's unique genetic make-up, making medicines safer and more effective for everyone. Although there still are no guidelines and immediate clinical implications for practitioners providing analgesia or anesthesia, it is essential to realize that trial-and-error pharmacotherapy and one-size-fits-all dogmas are bound to die. This review briefly outlines the genetic variability of pharmacokinetics and pharmacodynamics and discusses selected fields relevant to obstetric anesthesiologists for whom the challenges of translating pharmacogenetics to clinical practice hopefully are on their way.
Landau
Ruth
R
Service d'Anesthésiologie, Département APSI, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest 24, Genève 14, Switzerland. ruth.landau@hcuge.ch
D000328:Adult; D000773:Anesthesia, Obstetrical; D000777:Anesthetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010146:Pain / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000628:therapy
D000777:Anesthetics