title: Pathological studies on Bovine papilloma virus-fern interaction in hamsters.
abstract: Early pathological changes of Bovine papilloma virus (BPV-2)-fern (Pteridium aquilinum and Onychium contiguum fern) interaction in hamsters were studied. In bracken-exposed cattle, BPV induces malignancy in gastrointestinal and urinary bladder mucosa. Cutaneous warts were transmitted successfully in hamsters approximately after 3 months post inoculation while urinary bladder tumour of enzootic bovine haematuria cases were not transmitted. Histologically, tumour was diagnosed as fibroma. Onychium produced more pronounced effects than bracken fern which was characterized by significant reduction in body weight and testicular atrophy. BPV-fern interaction was not appreciable during early period of tumour induction and requires long-term studies for 12 to 18 months.
authors.affiliation: Division of Pathology, Indian Veterinary Research Institute, Izatnagar 243 122, India.
authors.forename: G D
authors.initials: GD
authors.lastname: Leishangthem
authors.forename: R
authors.initials: R
authors.lastname: Somvanshi
authors.forename: D R
authors.initials: DR
authors.lastname: Lauren
mesh_terms: D000818:Animals; D052688:Bovine papillomavirus 1 / Q000472:pathogenicity*; D015197:Carcinogenicity Tests / Q000379:methods*; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology*; D006224:Cricetinae; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D007189:Indans / Q000032:analysis / Q000633:toxicity*; D008297:Male; D008647:Mesocricetus; D030361:Papillomavirus Infections / Q000503:physiopathology / Q000635:transmission / Q000662:veterinary*; D029625:Pteridaceae / Q000009:adverse effects*; D032498:Pteridium / Q000009:adverse effects*; D012717:Sesquiterpenes / Q000032:analysis / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000821:virology; D014860:Warts / Q000473:pathology / Q000821:virology
chemical_list: D007189:Indans; D012717:Sesquiterpenes; C043680:ptaquiloside