Alitretinoin: a comprehensive review.
BACKGROUND
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carried out to determine how best to utilize this characteristic in treatments for conditions such as chronic hand dermatitis.


OBJECTIVE
To review the literature on alitretinoin.


METHODS
The scope of the review encompasses ways that alitretinoin is currently and may potentially be utilized.


CONCLUSIONS
Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. Topical treatment with alitretinoin can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US.
Cheng
Caleb
C
Jefferson Medical College, USA.
Michaels
Jason
J
Scheinfeld
Noah
N
D000284:Administration, Oral; D000077556:Alitretinoin; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006229:Hand Dermatoses / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000378:metabolism; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D018168:Receptors, Retinoic Acid; D000077556:Alitretinoin; D014212:Tretinoin