Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women.
OBJECTIVE
The objective of the study was to investigate the extent to which the daily incorporation of approximately 30 g of flaxseed, a rich source of lignans, omega-3 fatty acids, and fiber, for a period of 3 months into the diet of Native American postmenopausal women positively affects their lipid profiles.


METHODS
Fifty-five mild to moderately hypercholesterolemic (> or =5.1 to < or =9.8 mmol/L) Native American postmenopausal women were randomly assigned to control (A), flaxseed (B) or flaxseed + additional oat bran fiber (C) groups. Overnight fasting venous blood was collected at baseline and at the end of the treatment period to analyze lipid parameters.


RESULTS
Dietary flaxseed supplementation lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) by approximately 7% and 10%, respectively. However, the levels of high-density lipoprotein (HDL) and triglyceride remained unaltered. No changes were observed in other clinical and hematological parameters.


CONCLUSIONS
The results of the present study indicate that Native American postmenopausal women benefit from regular consumption of flaxseed by reducing their risk of cardiovascular disease as seen from lowered LDL-C and total cholesterol levels.
Patade
Anagha
A
Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.
Devareddy
Latha
L
Lucas
Edralin A
EA
Korlagunta
Kiranmayi
K
Daggy
Bruce P
BP
Arjmandi
Bahram H
BH
D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood* / Q000187:drug effects; D005260:Female; D019597:Flax; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000178:diet therapy* / Q000208:ethnology; D007198:Indians, North American; D008875:Middle Aged; D008517:Phytotherapy; D017698:Postmenopause / Q000097:blood* / Q000208:ethnology; D012639:Seeds; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides