Genomic analysis of closely related astroviruses.
To understand astrovirus biology, it is essential to understand factors associated with its evolution. The current study reports the genomic sequences of nine novel turkey astrovirus (TAstV) type 2-like clinical isolates. This represents, to our knowledge, the largest genomic-length data set available for any one astrovirus type. The comparison of these TAstV sequences suggests that the TAstV species contains multiple subtypes and that recombination events have occurred across the astrovirus genome. In addition, the analysis of the capsid gene demonstrated evidence for both site-specific positive selection and purifying selection.
Strain
Errol
E
Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA.
Kelley
Laura A
LA
Schultz-Cherry
Stacey
S
Muse
Spencer V
SV
Koci
Matthew D
MD
D000818:Animals; D019350:Astroviridae Infections / Q000821:virology; D052676:Avastrovirus / Q000235:genetics* / Q000302:isolation & purification; D016679:Genome, Viral; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014422:Turkeys; D014481:United States
D012367:RNA, Viral