Solid dispersion of meloxicam: factorially designed dosage form for geriatric population.
The objective of the present work was to improve the dissolution properties of the poorly water-soluble drug meloxicam by preparing solid dispersions with hydroxyethyl cellulose (HEC), mannitol and polyethylene glycol (PEG) 4000 and to develop a dosage form for geriatric population. Differential scanning calorimetry, X-ray diffractometry, Fourier transform infrared spectroscopy and scanning electron microscopy were used to investigate the solid-state physical structure of the prepared solid dispersions. Higher in vitro dissolution of solid dispersions was recorded compared to their corresponding physical mixtures and the pure drug. PEG 4000 in 1: 9 drug to carrier ratio exhibited the highest drug release (100.2%), followed by mannitol (98.2%) and HEC (89.5%) in the same ratio. Meloxicam-PEG 4000 solid dispersion was formulated into suspension and optimization was carried out by 23 factorial design. Formulations containing higher levels of methyl cellulose and higher levels of either sodium citrate or Tween 80 exhibited the highest drug release.
Pathak
Deepa
D
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, U.P. 281001, India.
Dahiya
Sunita
S
Pathak
Kamla
K
D001682:Biological Availability; D002021:Buffers; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002951:Citrates; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D045703:Emulsifying Agents; D005079:Excipients; D005853:Geriatrics; D008353:Mannitol / Q000737:chemistry; D000077239:Meloxicam; D008747:Methylcellulose; D011092:Polyethylene Glycols / Q000737:chemistry; D011136:Polysorbates; D000077559:Sodium Citrate; D012995:Solubility; D013535:Suspensions; D013843:Thiazines / Q000008:administration & dosage* / Q000737:chemistry; D013844:Thiazoles / Q000008:administration & dosage* / Q000737:chemistry
D002021:Buffers; D002951:Citrates; D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D045703:Emulsifying Agents; D005079:Excipients; D011136:Polysorbates; D013535:Suspensions; D013843:Thiazines; D013844:Thiazoles; D000077559:Sodium Citrate; D008353:Mannitol; D011092:Polyethylene Glycols; D004126:Dimethylformamide; D002482:Cellulose; C002283:hydroxyethylcellulose; D008747:Methylcellulose; D000077239:Meloxicam