title: Cavernomas in children with brain tumors: a late complication of radiotherapy.
abstract: BACKGROUND
  Delayed complications of radiation therapy comprise cerebral atrophy, radionecrosis and induction of tumors. Recent reports indicate the possibility of the "de-novo" formation of intracranial cavernomas in patients submitted to radiation therapy to the brain.
  
  
  OBJECTIVE
  To report three children, two with medulloblastomas and one with a pineal germinoma, treated with radiotherapy that developed intracerebral cavernous hemangiomas some years after treatment. With this work, we aim to draw attention to this occurrence in the neurosurgical community.
  
  
  RESULTS
  The patients were two girls and one boy with ages comprised between 2.5 and 7 years (mean 5.2 years). The average interval from irradiation to the appearance of cavernoma was of 5.3 years (range 5-6 years). The lesions were found during the routine neuroimaging studies performed for the follow-up of their primary neoplasms. No patient showed signs or symptoms related to the cavernomas. However, the three children will need both clinical and neuroimaging surveillance to monitor the evolution of these incidentally discovered lesions.
  
  
  CONCLUSIONS
  Intracranial cavernomas can occur years after cerebral radiation therapy. In spite of previous reports that show a high incidence of bleeding lesions, cavernomas may be found incidentally during the neuroimaging surveillance studies that are performed to children with brain tumors previously treated with radiotherapy. In these cases, a conservative attitude seems to be advisable, reserving surgery only for those lesions that grow or bleed.
authors.affiliation: Servicios Regional de Neurocirugía, Hospital Universitario Virgen de la Arrixaca, Murcia.
authors.forename: J F
authors.initials: JF
authors.lastname: Martínez-Lage
authors.forename: I
authors.initials: I
authors.lastname: de la Fuente
authors.forename: J
authors.initials: J
authors.lastname: Ros de San Pedro
authors.forename: J L
authors.initials: JL
authors.lastname: Fuster
authors.forename: M A
authors.initials: MA
authors.lastname: Pérez-Espejo
authors.forename: M T
authors.initials: MT
authors.lastname: Herrero
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006392:Hemangioma, Cavernous / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*