title: New steroidal derivatives synthesized using 3beta-hydroxyandrosten-17-one as starting material.
abstract: In this study, we synthesized some new substituted steroidal derivatives using 3beta-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.
authors.affiliation: Natural Compounds Department, National Research Center, Cairo Dokki, Egypt.
authors.forename: Nehad A
authors.initials: NA
authors.lastname: Abd El-Latif
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdulla
authors.forename: Abd El-Galil E
authors.initials: Ael-G
authors.lastname: Amr
mesh_terms: D045930:Anabolic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000728:Androgens / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000732:Androstanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000736:Androstenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000737:chemistry; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005837:Genitalia, Male / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D015394:Molecular Structure; D009132:Muscles / Q000187:drug effects; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D045930:Anabolic Agents; D000728:Androgens; D000732:Androstanols; D000736:Androstenes; D003687:Dehydroepiandrosterone