[Association between positive autoantibodies against AT1-receptor and cardiac remodeling in patients with hypertension].
OBJECTIVE
To observe the association between positive autoantibodies against AT(1)-receptor and cardiac remodeling in primary hypertensive patients.


METHODS
Echocardiography was performed and serum autoantibodies against AT(1)-receptor were detected by enzyme linked immunosorbent assay (ELISA) in 592 patients with primary hypertension. The differences on blood pressure level, course of hypertension, vasoactive substance and echocardiography parameters between the positive group and negative group were compared. Factors related to left ventricular enlargement were analyzed by multiple logistic regressions.


RESULTS
The positive percentage of autoantibodies against AT(1)-receptor was 38.0% (225/592). End-diastolic right atrial and left ventricular diameters in positive group were significantly larger than that in negative group (P = 0.049 and P = 0.044, respectively). Regression analysis demonstrated that positive autoantibodies against AT(1)-receptor, male gender, diastolic blood pressure and course of hypertension were related to left ventricular enlargement (all P < 0.05).


CONCLUSIONS
The autoantibodies against AT(1)-receptor is associated with left ventricular and right atrial enlargement in hypertensive patients.
Qiu
Yan
Y
Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science Technology, Wuhan 430022, China.
Zhu
Feng
F
Liao
Yu-hua
YH
Li
Zheng-zai
ZZ
Wang
Min
M
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D020257:Ventricular Remodeling
D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1