Histone as future drug target for malaria.
Malaria continues to be a major cause of mortality and morbidity in tropical countries and affecting around 100 countries of the world. As per WHO estimates, 300-500 million are being infected and 1-3 million deaths annually due to malaria. With the emerging knowledge about genome sequence of all the three counterparts involved in the disease of malaria, the parasite Plasmodium, vector Anopheles and host Homo sapien have helped the scientists to understand interactions between them. Simultaneous advancement in technology further improves the prospects to discover new targets for vaccines and drugs. Though the malaria vaccine is still far away in this situation there is need to develop a potent and affordable drug(s). Histones are the key protein of chromatin and play an important role in DNA packaging, replication and gene expression. They also show frequent post-translation modifications. The specific combinations of these posttranslational modifications are thought to alter chromatin structure by forming epigenetic bar codes that specify either transient or heritable patterns of genome function. Chromatin regulators and upstream pathways are therefore seen as promising targets for development of therapeutic drugs.
Rawat
D S
DS
Division of Biochemistry & Biotechnology, National Institute of Communicable Diseases, Delhi.
Lumb
V
V
Sharma
Y D
YD
Pasha
S T
ST
Singh
G
G
D000818:Animals; D000852:Anopheles / Q000235:genetics / Q000469:parasitology; D000962:Antimalarials / Q000627:therapeutic use*; D015894:Genome, Human; D018503:Genome, Protozoan; D023281:Genomics; D006657:Histones / Q000627:therapeutic use*; D006790:Host-Parasite Interactions; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D017780:Malaria Vaccines; D010961:Plasmodium / Q000235:genetics
D000962:Antimalarials; D006657:Histones; D017780:Malaria Vaccines