One new bufadienolide from Chinese drug "Chan'Su".
A new bufadienolide named 16beta-acetoxy-bufarenogin (1), together with six known bufadienolides, namely, 11alpha,12beta-dihydroxy-bufalin (2), bufotalin (3), hellebrigenin (4), desacetylbufotalin (5), gamabufotalin (6), and resibufagin (7) were isolated from Chan'Su. Of these, 2 was a new natural product. Their structures were elucidated by spectral methods. The cytotoxic activities in vitro of these compounds have been assayed against HeLa cell line. They all showed strong cytotoxic activities.
Qiao
Li
L
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Huang
Yong-Fu
YF
Cao
Jia-Qing
JQ
Zhou
Yu-Zhi
YZ
Qi
Xiu-Lan
XL
Pei
Yue-Hu
YH
D000818:Animals; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002023:Bufo bufo; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002018:Bufanolides; C095591:chan su