title: Tamsulosin MR and OCAS (modified release and oral controlled absorption system): current therapeutic uses.
abstract: BACKGROUND
  Although tamsulosin is mainly used to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia, with better understanding of functional anatomy and distribution of alpha(1) receptors, it is also indicated in other conditions of genito-urinary tract in both men and women.
  
  
  OBJECTIVE
  To detail the therapeutic use and clinical effects of tamsulosin.
  
  
  METHODS
  The scope of the review was related to tamsulosin and its therapeutic application in conditions of genitourinary tract. Publications were searched from Pubmed and Medline from 1975 to 2007 using the search words tamsulosin, lower urinary tract symptoms, alpha receptors and blockers.
  
  
  CONCLUSIONS
  The management of benign prostatic hyperplasia was transurethral resection of prostate until simpler and alternative treatments were tried in the last two decades, particularly alpha(1) adrenoceptor-blocking agents. Tamsulosin is a potent, third-generation selective alpha(1A) adrenoceptor-blocking agent.
authors.affiliation: St Bartholomew's Hospital, Department of Genito-Urinary Surgery, West Smithfield, London EC1A 7BE, UK. Vinod.nargund@bartsandthelondon.nhs.uk
authors.forename: Vinod H
authors.initials: VH
authors.lastname: Nargund
authors.forename: Alistair D R
authors.initials: AD
authors.lastname: Grey
mesh_terms: D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy*; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000188:drug therapy* / Q000209:etiology; D011470:Prostatic Hyperplasia / Q000150:complications; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects / Q000378:metabolism; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000077409:Tamsulosin
chemical_list: D000317:Adrenergic alpha-Antagonists; D003692:Delayed-Action Preparations; D018340:Receptors, Adrenergic, alpha-1; D013449:Sulfonamides; D000077409:Tamsulosin