Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review.
For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor. A new assay that detects antibodies to citrullinated peptides, called the anti-CCP assay, has demonstrated a comparable sensitivity but a much higher specificity than the RF test. This paper reviews RF and anti-CCP in rheumatoid arthritis and examines the usefulness of each autoantibody in RA testing.
Lee
Ashley Nicole
AN
University of Southern Mississippi, Hattiesburg, MS, USA. starsweeper18@hotmail.com
Beck
Carolyn E
CE
Hall
Margot
M
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D007155:Immunologic Factors / Q000097:blood*; D010456:Peptides, Cyclic / Q000276:immunology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012217:Rheumatoid Factor / Q000097:blood*; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D007155:Immunologic Factors; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor