title: Intramolecular azide-alkyne cycloaddition for the fast assembly of structurally diverse, tricyclic 1,2,3-triazoles.
abstract: The synthesis of novel tricyclic 1,2,3-triazoles starting from cyclic epoxides via the sequential azidolysis, propargylation and 1,3-dipolar cycloaddition is described. Derivatization by N-arylation reaction and the synthesis of enantiomerically pure compounds is also reported. Some of these compounds exhibit significant affinity for the sigma-1 receptor.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Avenida Països Catalans 16, Tarragona, Spain.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Oliva
authors.forename: Ute
authors.initials: U
authors.lastname: Christmann
authors.forename: Daniel
authors.initials: D
authors.lastname: Font
authors.forename: Félix
authors.initials: F
authors.lastname: Cuevas
authors.forename: Pablo
authors.initials: P
authors.lastname: Ballester
authors.forename: Helmut
authors.initials: H
authors.lastname: Buschmann
authors.forename: Antoni
authors.initials: A
authors.lastname: Torrens
authors.forename: Susana
authors.initials: S
authors.lastname: Yenes
authors.forename: Miquel A
authors.initials: MA
authors.lastname: Pericàs