Autoimmune response to Chlamydia trachomatis infection and in vitro fertilization outcome.
This observational study was conducted in 235 patients undergoing IVF who had a cervical swab positive for Chlamydia trachomatis and who underwent antibiotic treatment until a negative cervical swab before IVF attempt. After oocyte retrieval, follicular fluids of 109 patients out of 228 still showed the presence of IgA antichlamydia antibodies and a significantly lower pregnancy and implantation rate; therefore we conclude that patients should undergo IVF procedure after serum antichlamydia IgA tests negative.
Pacchiarotti
Arianna
A
Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Policlinico Umberto Io, Università di Roma La Sapienza, Rome, Italy. arypac@aliceposta.it
Sbracia
Marco
M
Mohamed
Mohamed A
MA
Frega
Antonio
A
Pacchiarotti
Alessandro
A
Espinola
Salomè M B
SM
Aragona
Cesare
C
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000378:metabolism; D015551:Autoimmunity; D002584:Cervix Uteri / Q000382:microbiology*; D002690:Chlamydia Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000276:immunology / Q000302:isolation & purification*; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007558:Italy; D054315:Oocyte Retrieval; D011247:Pregnancy; D018873:Pregnancy Rate; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D007070:Immunoglobulin A