Synthesis and study of antiviral and anti-radical properties of aminophenol derivatives.
A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered free-radical intermediates was investigated. Of the compounds tested, the highest activity in suppressing replication of Herpes simplex type l viruses was displayed by N-acyl and N-aryl derivatives of 4,6-di-tert-butyl-2-aminophenol, which were able to interact with organic free radicals and, at the same time, manifested low reactivity towards reactive oxygen species.
Shadyro
O
O
Department of Chemistry of the Belarusian State University, Nezavisimosty Avenue 4, 220030 Minsk, Belarus. shadyro@open.by
Ksendzova
G
G
Polozov
G
G
Sorokin
V
V
Boreko
E
E
Savinova
O
O
Dubovik
B
B
Bizunok
N
N
D000627:Aminophenols / Q000138:chemical synthesis / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
D000627:Aminophenols; D000998:Antiviral Agents; D005609:Free Radicals; D017382:Reactive Oxygen Species