title: Reporting a fatality during tumescent liposuction.
abstract: Deaths of patients during elective surgery have drawn attention to the danger of anesthesia. Tumescent local anesthesia is subcutaneous infiltration of large volumes of dilute lidocaine with epinephrine to produce vasoconstriction while delivering anesthesia over large areas without lidocaine toxicity. This report documents the case of a 38-year-old woman who attended an outpatient clinic to undergo liposuction of the abdomen and bilateral hips and thighs. According to one witness, around 30 min after anesthesia administration, the victim suffered an episode of tonic-clonic convulsion. When the emergency medical services arrived the patient was in asystole. She died in spite of attempted cardiopulmonary resuscitation. The patient had no significant past medical history including no history of allergies or any known complications with anesthesia. A complete autopsy was performed and possible causes of death such as myocardial infarction, aspiration of food or foreign body, and pulmonary embolism were discarded. Anaphylactic shock was considered a possible but unlikely explanation for the fatality. Toxicological analyses revealed the presence of lidocaine and mepivacaine in heart blood, at concentrations of 4.9 and 16.2mg/L, respectively. All drugs involved in the case were detected using gas chromatography with nitrogen-phosphorus detector and confirmed using gas chromatography-mass spectrometry full scan mode after solid-phase extraction using Chem-Elut columns. An additional high-performance liquid chromatography coupled to diode-array detection screening also obtained the same results. Based on the autopsy findings, case history, and toxicology results, the forensic pathologists ruled that the cause of death was an overdose of local anesthetic agents. The Court of Law ruled the death as an involuntary homicide due to gross negligence.
authors.affiliation: Instituto Nacional de Toxicología y Ciencias Forenses, Ministerio de Justicia, C/Luis Cabrera 9, 28002 Madrid, Spain. ma.martinez@mju.es
authors.forename: María A
authors.initials: MA
authors.lastname: Martínez
authors.forename: Salomé
authors.initials: S
authors.lastname: Ballesteros
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Segura
authors.forename: Manuel
authors.initials: M
authors.lastname: García
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000779:Anesthetics, Local / Q000097:blood / Q000506:poisoning*; D062787:Drug Overdose; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D004837:Epinephrine / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning*; D015187:Lipectomy / Q000009:adverse effects*; D008318:Malpractice; D008619:Mepivacaine / Q000097:blood / Q000506:poisoning*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D008012:Lidocaine; D008619:Mepivacaine; C001173:monoethylglycinexylidide; D004837:Epinephrine