ent-Kaurane Diterpenoids from Isodon nervosus.
A pentacyclic ent-kauranoid, nervonin A ( 1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J ( 2- 10), along with 10 known ones ( 11- 20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.
Li
Li-Mei
LM
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Li
Guo-You
GY
Ding
Li-Sheng
LS
Yang
Li-Bin
LB
Zhao
Yong
Y
Pu
Jian-Xin
JX
Xiao
Wei-Lie
WL
Han
Quan-Bin
QB
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; C529410:nervonin A