title: Association between dietary fat intake, liver fat, and insulin sensitivity in sedentary, abdominally obese, older men.
abstract: Whether dietary fat influences the interaction between liver fat, visceral adipose tissue (VAT), and metabolic risk is unclear. Thus, we sought to determine the independent associations between 1 and 10 d dietary fat intake, liver fat, and VAT on insulin sensitivity using a cross-sectional design. Liver fat score (LFS) was assessed by computed tomography and VAT by magnetic resonance imaging in 42 abdominally obese older men. Insulin sensitivity was measured by the hyperinsulinemic-euglycemic clamp technique. Diet composition was determined from self-recorded diet records for 1 and 10 d preceding the assessment of LFS. LFS was positively associated with the 10 d average fat and alcohol intake, but not with any 1 d average dietary variables. VAT (r = -0.36) and LFS (r = -0.32) were both negatively correlated with insulin sensitivity (p < 0.05). When LFS and VAT were entered in the same model, only VAT was an independent predictor of insulin sensitivity (p < 0.05). Control for the average 10 d alcohol consumption and fat intake improved the association between insulin sensitivity and LFS (from r = -0.32, p > 0.10 to r = -0.49, p < 0.05), but not VAT. In fact, after control for the 10 d dietary variables, both LFS and VAT were independent predictors of insulin sensitivity (p < 0.05). This was not true for any of the 1 d dietary intake variables. In conclusion, liver fat is associated with dietary fat intake and alcohol consumption over 10 d, but not 1 d. Furthermore, dietary habits may influence the relationship between liver fat and insulin sensitivity.
authors.affiliation: School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kuk
authors.forename: Lance E
authors.initials: LE
authors.lastname: Davidson
authors.forename: Robert
authors.initials: R
authors.lastname: Hudson
authors.forename: Katherine
authors.initials: K
authors.lastname: Kilpatrick
authors.forename: Kinga
authors.initials: K
authors.lastname: Bacskai
authors.forename: Robert
authors.initials: R
authors.lastname: Ross
mesh_terms: D050153:Abdominal Fat / Q000502:physiology*; D050154:Adiposity / Q000502:physiology*; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D008099:Liver / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats