title: Association of central corneal thickness and 24-hour intraocular pressure fluctuation.
abstract: OBJECTIVE
  To evaluate the association between office-hour central corneal thickness (CCT) and 24-hour intraocular pressure (IOP) fluctuation in patients with glaucoma.
  
  
  METHODS
  Observational case-control study.
  
  
  METHODS
  Measurements of IOP were obtained every 2 hours during a 24-hour period from 52 untreated glaucoma patients and 29 age-matched normal control subjects housed in a sleep laboratory. Habitual IOP measurements were obtained using a pneumatonometer in the sitting positions during the diurnal/wake period (7 AM to 11 PM) and in the supine position during the nocturnal/sleep period (11 PM to 7 AM). CCT was measured in all subjects using ultrasound pachymetry once during office hours. The association between IOP fluctuation (peak IOP-trough IOP) during the 24-hour period and the office-hour CCT was assessed in both glaucoma patients and healthy age-matched controls using Spearman rank order correlation.
  
  
  RESULTS
  There was no statistically significant correlation between IOP fluctuation and CCT in glaucomatous (P=0.405) and normal subjects (P=0.456).
  
  
  CONCLUSIONS
  Twenty-four-hour IOP fluctuations were not correlated with single CCT measurements taken during office hours in glaucoma patients.
authors.affiliation: Department of Ophthalmology, University of California, Irvine, USA. smosaed@uci.edu
authors.forename: Sameh
authors.initials: S
authors.lastname: Mosaed
authors.forename: Winston Douglas
authors.initials: WD
authors.lastname: Chamberlain
authors.forename: John H K
authors.initials: JH
authors.lastname: Liu
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Medeiros
authors.forename: Robert N
authors.initials: RN
authors.lastname: Weinreb
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology*; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011187:Posture; D014065:Tonometry, Ocular; D014463:Ultrasonography