The diagnostic value of macrophage migration inhibitory factor (MIF) in gastric cancer.
The present study was conducted to investigate the sensitivity, specificity, predictive values and accuracy of serum MIF, CEA, CA 19-9 levels and their various combinations in patients with gastric cancer. Study group consists of pathologically verified, gastric cancer (n = 63) and apparently healthy controls (n = 50). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Serum values of patients were significantly higher than the controls (p = 0.011). Diagnostic sensitivity and specificity, predictive values and accuracies were calculated for each marker and their various combinations. The best results were achieved with the marker combination of MIF-CEA-CA 19-9 and MIF-CEA combination. In our opinion, the combination of the markers MIF-CEA is a valuable diagnostic tool for gastric cancer.
Camlica
Hakan
H
Preventive Oncology, Biostatistics and Epidemiology, Institute of Oncology, University of Istanbul, Capa, 34390 Istanbul, Turkey. hcamlica@istanbul.edu.tr
Duranyildiz
Derya
D
Oguz
Hilal
H
Oral
Ethem Nezih
EN
Yasasever
Vildan
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000097:blood*; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D008263:Macrophage Migration-Inhibitory Factors; D011956:Receptors, Cell Surface; C065686:carcinoembryonic antigen binding protein, human; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human