title: Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis.
abstract: Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
authors.affiliation: Department of Rheumatology, University Hospital, Uppsala, Sweden. eva.baecklund@swipnet.se
authors.forename: Eva
authors.initials: E
authors.lastname: Baecklund
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Natkunam
authors.forename: Carin
authors.initials: C
authors.lastname: Backlin
authors.forename: Anastasia
authors.initials: A
authors.lastname: Iliadou
authors.forename: Johan
authors.initials: J
authors.lastname: Askling
authors.forename: Anders
authors.initials: A
authors.lastname: Ekbom
authors.forename: Nils
authors.initials: N
authors.lastname: Feltelius
authors.forename: Lars
authors.initials: L
authors.lastname: Klareskog
authors.forename: Gunilla
authors.initials: G
authors.lastname: Enblad
authors.forename: Izidore S
authors.initials: IS
authors.lastname: Lossos
authors.forename: Ronald
authors.initials: R
authors.lastname: Levy
authors.forename: Christer
authors.initials: C
authors.lastname: Sundström
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008840:Microfilament Proteins; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C476824:GCSAM protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins