Viral diversity limits immune diversity in asymptomatic phase of HIV infection.
We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number "immune diversity threshold". Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.
Iwami
Shingo
S
Graduate School of Science and Technology, Shizuoka University, Japan.
Nakaoka
Shinji
S
Takeuchi
Yasuhiro
Y
D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008962:Models, Theoretical; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology