title: Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women.
abstract: This study aimed to seek whether habitual fish and seafood or n-3 long-chain PUFA intake could influence the occurrence of depressive episodes. In a subsample from the French SU.VI.MAX cohort, dietary habits have been assessed during the first 2 years of the follow-up (six 24-h records) and declarations of antidepressant prescription, taken as markers of depressive episodes, have been recorded during the 8-year follow-up. Subjects consuming fatty fish or with an intake of long-chain n-3 PUFA higher than 0.10% of energy intake had a significantly lesser risk of any depressive episode and of recurrent depressive episodes, but not of single depressive episode. These associations were stronger in men and in non-smokers. In contrast, smokers eating fatty fish had an increased risk of recurrent depression. These results suggest that a usual intake of fatty fish or long-chain n-3 PUFA may decrease the risk of recurrent depression in non-smokers.
authors.affiliation: Unité Nutrition et Régulation Lipidique des Fonctions Cérébrales (NuRéLiCe), UR 909, Institut National de la Recherche Agronomique (INRA), Centre de Recherche de Jouy, Jouy-en-Josas, France. pierre.astorg@jouy.inra.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Astorg
authors.forename: Aline
authors.initials: A
authors.lastname: Couthouis
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bertrais
authors.forename: Nathalie
authors.initials: N
authors.lastname: Arnault
authors.forename: Pierre
authors.initials: P
authors.lastname: Meneton
authors.forename: Philippe
authors.initials: P
authors.lastname: Guesnet
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Alessandri
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
mesh_terms: D003863:Depression / Q000453:epidemiology*; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D017747:Seafood
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils