Vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence.
The vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence has been investigated. It has been shown that catalyst loadings as low as 8 mol % readily allow for good yields and excellent diastereoselectivities (>20:1) for a series of Grignard reagents and aldehydes.
Mueller
Amanda J
AJ
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Jennings
Michael P
MP