title: [Experimental rationale for a transscleral approach to thermotherapy for intraocular tumors, by using a photosensitizer].
abstract: The authors present the results of an experimental study of the pattern of distribution of laser radiation at a wavelength of 810 nm in the normal and Photosens-photosensitized eye tissues and analyze the distribution of a temperature at the sclera/choroidea/ tumor border during transscleral radiation delivery. To further the goal, the authors have resorted to computer mathematical simulation. In convergent-beam radiation supply, the proportion of a scattered radiation component has been ascertained to be lower in the surface scleral layer than that in the layers adjacent to the choroidea and the base of a tumor. On entering the sclera, a splash of light decreases and power density and radiation-induced heating of the deeply located tissues increase. Thus, the major hyperthermic effects show themselves in the tumor rather than on the sclera.
authors.forename: V G
authors.initials: VG
authors.lastname: Likhvantseva
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Merzliakova
authors.forename: M V
authors.initials: MV
authors.lastname: Vereshchagina
authors.forename: S A
authors.initials: SA
authors.lastname: Shevchik
authors.forename: V B
authors.initials: VB
authors.lastname: Loshchenov
authors.forename: S G
authors.initials: SG
authors.lastname: Kuz'min
authors.forename: G N
authors.initials: GN
authors.lastname: Vorozhtsov
mesh_terms: D003198:Computer Simulation; D005134:Eye Neoplasms / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012590:Sclera; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents