title: Lycopene ameliorates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rat.
abstract: Peripheral neuropathy is one of the common complications of diabetes mellitus. It is frequently associated with debilitating pain. The present study was designed to investigate effect of Lycopene, a carotenoid found in tomatoes, on hyperalgesia and cold allodynia in streptozotocin (STZ) induced diabetic rats. After 4-weeks of STZ injection, diabetic mice exhibited a significant thermal hyperalgesia cold allodynia, hyperglycemia and loss of body weights as compared with control rats. Chronic treatment of lycopene for 4 weeks significantly attenuated the cold allodynia and thermal hyperalgesia. The results emphasize the role of antioxidant such as lycopene as an adjuvant therapy in the treatment of diabetic neuropathy.
authors.affiliation: Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences UGC Center of Advanced Studies, Panjab University, Chandigarh 160 014 India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Kuhad
authors.forename: Kanwaljit
authors.initials: K
authors.lastname: Chopra
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D003080:Cold Temperature; D048909:Diabetes Complications / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000188:drug therapy; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy*; D000077276:Lycopene; D008297:Male; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D002338:Carotenoids; D013311:Streptozocin; D000077276:Lycopene