Associations of Human Leukocyte Antigen (HLA) haplotypes with risk of developing lymphoproliferative disorders after renal transplantation.
BACKGROUND
Genetic susceptibility to lymphomas associated with human leukocyte antigens (HLA) has been broadly reported for many years. In this study, we aimed to evaluate the potential impact of various HLA antigens on the incidence of lymphoproliferative disorders in renal allograft recipients.


METHODS
In this retrospective cross-sectional study, we analysed data of PTLD patients from two of the major Iranian transplant centers and compared them with 1155 normal kidney recipients. Potential impact of previously reported relevant HLA antigens was assessed. For assessing independent impact of various factors, we used a multivariate proportional hazard analysis using Cox regression.


RESULTS
Patients in the two groups were similar in their age at transplantation. PTLD group was significantly female predominated (61% vs. 33%). chi(2) showed a higher frequency of HLA-BW22 in the PTLD group. HLA-A2, HLA-A11, HLA-B5 and HLA-B35 concomitant with azathioprine based immunosuppression were significantly associated with PTLD occurrence.


CONCLUSIONS
Our findings can further alert us toward the initial signs of PTLDs in high risk kidney allograft recipients. Future prospective studies with larger patient population seem necessary for confirming our findings.
Pourfarziani
Vahid
V
Nephrology & Urology Research Center (NURC), Baqiyatallah University of Medical Sciences, Tehran, Iran.
Einollahi
Behzad
B
Taheri
Saeed
S
Nemati
Eghlim
E
Nafar
Mohsen
M
Kalantar
Ebrahim
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D015994:Incidence; D007492:Iran; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D006680:HLA Antigens