[Factors associated with cardiac arrhythmias in patients with type 2 diabetes mellitus and myocardial infarction].
An analysis of some features of heart arrhythmias in patients with myocardial infarction (MI) and type 2 diabetes mellitus (DM2) was performed. The study revealed that arrhythmias (usually extrasystoles or atrial fibrillation) were more common in patients with DM type 2 (42.1% in DM2, and 30.4% in non-DM patients, p = 0.0041) and demonstrated a direct correlation with coronary and myocardial dysfunction. In patients with DM2, arrhythmias were associated with the duration of DM and HbA1c level. In severe metabolic decompensation (HbA1c > 8.5%) and in cases with a relatively low HbA1c level (< 7%) arrhythmias were more frequent than in patients with an HbA1c level between 7.0% and 8.5%. In patients with an HbA1c level < 7.0%, the threat of hypoglycemia is increased, often due to insulinotherapy, as a possible arrhythmogenic factor associated with a relative elevation of immunoreactive insulin and C-peptide and diabetic nephropathy (DN). Severe DM decompensation (HbA1c > 8.5%) was associated with metabolic disturbances and toxic effect of hyperglycemia. Cardiac arrhythmias, systolic dysfunction, and DN are prognostically unfavorable factors influencing the survival rate in patients with MI and DM2.
Panova
E I
EI
Kruglova
N E
NE
D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors