[Effect of aminoguanidine on hemodynamics and nitrogen monoxide in hemorrhagic shock in rabbit].
OBJECTIVE
To explore the effect of aminoguanidine (AG) on hemodynamics and nitric oxide (NO) in hemorrhagic shock in rabbit.


METHODS
Shock was produced in twenty rabbits by femoral artery blood letting, and they were randomly divided into two groups with treatment with saline (control group) or AG (each n=10). Pclab system and nitric acid reductase methods were performed to detect hemodynamics parameters and NO levels at preshock, postshock (30 minutes and 150 minutes) and 30 minutes and 180 minutes after resuscitation respectively.


RESULTS
No significant differences were observed in hemodynamics parameters and NO levels between the two groups before resuscitation. Whereas after resuscitation, hemodynamics parameters such as systolic arterial pressure (SAP), heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP) and the max and minimum first derivative of left ventricular pressure (+/-dp/dt max) were all improved greatly in the two groups. AG decreased serum NO level significantly, while saline did not have such effect, suggesting that AG had a longer and more efficient effect against hemorrhagic shock (P<0.05 or P<0.01).


CONCLUSIONS
AG can improve hemodynamics parameters and decrease NO level in hemorrhagic shock in rabbit.
Gao
Zhi-ping
ZP
Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, Hunan, China.
Liao
Duan-fang
DF
Li
Bo-ping
BP
Liu
De-ping
DP
Liu
Jian-zhi
JZ
Tang
Chao-ke
CK
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D011817:Rabbits; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000503:physiopathology* / Q000628:therapy
D006146:Guanidines; D009569:Nitric Oxide; C004479:pimagedine