title: Sarcoidosis in the setting of idiopathic chronic bronchiolitis with airway colonization from P. aeruginosa: treatment with low-dose macrolides.
abstract: It has long been suggested that infectious agents may trigger sarcoidosis through their infectious or antigenic properties. A patient with airway colonization from P. aeruginosa in the setting of idiopathic bronchiolitis (IB) mimicking diffuse panbronchiolitis (DPB) developed sarcoidosis. Impressive clinical and radiological improvement of both bronchiolitis and sarcoidosis features was achieved with a one-year treatment with low-dose erythromycin, thus suggesting a possible link between the two conditions in this specific case. Pathogenic hypotheses and therapeutic implications are specifically discussed.
authors.affiliation: Thoracic Endoscopy and Pulmonology Unit, Maggiore Hospital, Bologna, Italy. rocco.trisolini@ausl.bologna.it
authors.forename: Rocco
authors.initials: R
authors.lastname: Trisolini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cancellieri
authors.forename: Daniela
authors.initials: D
authors.lastname: Paioli
authors.forename: Marcellino
authors.initials: M
authors.lastname: Burzi
authors.forename: Paolo
authors.initials: P
authors.lastname: Orlandi
authors.forename: Marco
authors.initials: M
authors.lastname: Patelli
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001988:Bronchiolitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D011552:Pseudomonas Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D012137:Respiratory System / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides