Total agenesis of the corpus callosum in a patient with childhood-onset schizophrenia.
The hypothesis that schizophrenia involves aberrant inter-hemispheric communication has a long pedigree, however its precise role remains unclear. We therefore report the case of a total agenesis of the corpus callosum in a 21-year-old man with childhood-onset schizophrenia. The presence of schizophrenia with very early onset on absence of corpus callosum offers an opportunity to examine neurodevelopmental model and theories regarding to interhemispheric communication in the pathogenesis of psychosis.
Hallak
Jaime Eduardo Cecilio
JE
Department of Neurology, Psychiatry and Psychological Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. jhallak@fmrp.usp.br
Crippa
José Alexandre de Sousa
JA
Pinto
Joel Porfírio
JP
Machado de Sousa
João Paulo
JP
Trzesniak
Clarissa
C
Dursun
Serdar Murat
SM
McGuire
Phillip
P
Deakin
John Francis William
JF
Zuardi
Antonio Waldo
AW
D000328:Adult; D061085:Agenesis of Corpus Callosum; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012561:Schizophrenia, Childhood / Q000209:etiology* / Q000473:pathology