title: Helicobacter pylori prevalence in diabetes mellitus patients with dyspeptic symptoms and its relationship to glycemic control and late complications.
abstract: BACKGROUND
  There are contradictory reports on Helicobacter pylori prevalence and its relationship to late complications of diabetes mellitus (DM). The aim of this study was to determine the prevalence of H. pylori infection in type 2 DM patients and to evaluate the relationship between H. pylori infection and the glycemic control, late complications.
  
  
  METHODS
  A total of 141 type 2 DM patients and 142 nondiabetic subjects with upper gastrointestinal symptoms were enrolled in the study. All patients underwent upper gastrointestinal endoscopy with biopsy specimens obtained from gastric antrum and corpus. H. pylori status was evaluated in each patient by both the rapid urease test and histopathological examination. Plasma glucose, HbA1c, microalbuminuria in 24 h collected urine, electroneuromyography, and fundoscopic examinations were performed in all subjects.
  
  
  RESULTS
  The prevalence of H. pylori infection was 61.7% and 58.5%, respectively, among type 2 diabetic patients and nondiabetic controls and was not statistically significant (P = 0.577). The duration of diabetes, fasting blood glucose and haemoglobin A1c levels, nephropathy and retinopathy prevalence did not differ significantly between the two groups (diabetics versus nondiabetics). There was no late complication in 60.3% of the type 2 diabetic patients as compared to at least one late complication in the remainders. A statistically significant correlation was found between H. pylori infection and the presence of neuropathy (P = 0.021).
  
  
  CONCLUSIONS
  The prevalence of H. pylori infection did not differ significantly between the diabetic patients and nondiabetic controls. Interestingly, diabetics with H. pylori infection had a higher incidence of neuropathy, although there was no association between the duration and regulation of diabetes, retinopathy, nephropathy and H. pylori status.
authors.affiliation: Department of Gastroenterology, Baskent University Faculty of Medicine, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Demir
authors.forename: Huseyin Savas
authors.initials: HS
authors.lastname: Gokturk
authors.forename: Nevin Akcaer
authors.initials: NA
authors.lastname: Ozturk
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kulaksizoglu
authors.forename: Ender
authors.initials: E
authors.lastname: Serin
authors.forename: Ugur
authors.initials: U
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000382:microbiology*; D003928:Diabetic Nephropathies / Q000382:microbiology; D003929:Diabetic Neuropathies / Q000382:microbiology*; D003930:Diabetic Retinopathy / Q000382:microbiology; D004415:Dyspepsia / Q000378:metabolism* / Q000382:microbiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D016481:Helicobacter Infections / Q000453:epidemiology / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin