title: Circulating stromal cell derived factor-1alpha (SDF-1alpha) is predictive of distant metastasis in gastric carcinoma.
abstract: This study was conducted to investigate the value of the pretreatment circulating stromal cell derived factor-1alpha(SDF-1alpha) in patients with gastric carcinoma. We measured SDF-1alpha serum concentrations and evaluated the relationship between serum SDF-1alpha and serum vascular endothelial growth factor (VEGF) levels and clinical factors in 107 gastric cancer patients. Serum levels of SDF-1alpha and VEGF levels were higher in gastric cancer patients than in controls (p < 0.001). Serum SDF-1alpha levels were higher in metastatic patients than non-metastatic patients (p < 0.001). SDF-1alpha levels were correlated with the presence of distant metastases (r = 0.528; p < 0.001) and correlated with VEGF levels (r = 0.789; p < 0.001). SDF-1alpha might serve as a possible marker for predicting or monitoring distant metastasis in gastric carcinoma.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea.
authors.forename: In Sook
authors.initials: IS
authors.lastname: Woo
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Hong
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Byun
authors.forename: Jin-Hyung
authors.initials: JH
authors.lastname: Kang
authors.forename: Hae-Myung
authors.initials: HM
authors.lastname: Jeon
authors.forename: Myung Gyu
authors.initials: MG
authors.lastname: Choi
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D054377:Chemokine CXCL12 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A