Plasma homocysteine level in cardiac syndrome X and its relation with duke treadmill score.
OBJECTIVE
To investigate the plasma homocysteine level and the relationship between plasma homocysteine level and duke treadmill score (DTS) in cardiac syndrome X (CSX) patients.


METHODS
Seventy-nine patients (36 male, 43 female, mean age: 50 +/- 8.8 years) admitted to Gazi University Hospital, Ankara, Turkey with typical effort angina, positive stress test, and angiographically normal coronary arteries between January and September 2006 were included in this prospective and controlled study. Thirty asymptomatic patients (11 male, 19 female, mean age: 47.6 +/- 8.3 years) with 2 cardiovascular risk factors were chosen as a control group. Plasma homocysteine level was measured in both groups and DTS was calculated in the CSX group. Plasma homocysteine was measured with the AxSYM homocysteine immunoassay method in both groups.


RESULTS
Plasma homocysteine level was higher in the CSX group compared to the control group (16.5 +/- 4.9 micromol/L, n=79, versus 12.4 +/- 4.1 micromol/L, n=30, p<0.001). The DTS was -2.7 +/- 5.3 in the CSX group. There was a negative correlation between the DTS and homocysteine levels in the CSX group. (r= -0.506, p<0.001).


CONCLUSIONS
Plasma homocysteine level, which is known to cause endothelial dysfunction and microvascular ischemia were higher in CSX patients. Also, this increase in homocysteine level inversely correlated with the DTS, which represents the magnitude of ischemia.
Timurkaynak
Timur
T
Department of Cardiology, Gazi University Medical School, Besevler, Ankara, Turkey. ttimurkaynak@gmail.com
Balcioglu
Serhat
S
Arslan
Ugur
U
Kocaman
Sinan A
SA
Cengel
Atiye
A
D016022:Case-Control Studies; D005080:Exercise Test; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000097:blood* / Q000145:classification / Q000175:diagnosis*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood; D011446:Prospective Studies
D006710:Homocysteine