title: Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese.
abstract: Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-beta gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 +/- 0.65 vs 2.42 +/- 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 +/- 1.14 vs 5.47 +/- 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance.
authors.affiliation: Department of Medicine, University of Hong Kong, Hong Kong, China.
authors.forename: Louisa Y F
authors.initials: LY
authors.lastname: Wong
authors.forename: Kwok Leung
authors.initials: KL
authors.lastname: Ong
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
authors.forename: Raymond Y H
authors.initials: RY
authors.lastname: Leung
authors.forename: Yu Bun
authors.initials: YB
authors.lastname: Man
authors.forename: Tai Hing
authors.initials: TH
authors.lastname: Lam
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D005838:Genotype; D005951:Glucose Tolerance Test; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D005340:Fibrinogen