title: Transmission of simian immunodeficiency virus carrying multiple cytotoxic T-lymphocyte escape mutations with diminished replicative ability can result in AIDS progression in rhesus macaques.
abstract: Cytotoxic T-lymphocyte (CTL) responses frequently select for immunodeficiency virus mutations that result in escape from CTL recognition with viral fitness costs. The replication in vivo of such viruses carrying not single but multiple escape mutations in the absence of the CTL pressure has remained undetermined. Here, we have examined the replication of simian immunodeficiency virus (SIV) with five gag mutations selected in a macaque possessing the major histocompatibility complex haplotype 90-120-Ia after its transmission into 90-120-Ia-negative macaques. Our results showed that even such a "crippled" SIV infection can result in persistent viral replication, multiple reversions, and AIDS progression.
authors.affiliation: International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Seki
authors.forename: Miki
authors.initials: M
authors.lastname: Kawada
authors.forename: Akiko
authors.initials: A
authors.lastname: Takeda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Igarashi
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matano
mesh_terms: D000818:Animals; D015683:Gene Products, gag / Q000235:genetics; D008253:Macaca mulatta; D009154:Mutation; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000254:growth & development / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019562:Viral Load
chemical_list: D015683:Gene Products, gag; C115853:simian immunodeficiency virus gag p55