title: [Target-controlled infusion (TCI) - a concept with a future?: state-of-the-art, treatment recommendations and a look into the future].
abstract: Over the last 10 years the technique of target-controlled infusion (TCI) has substantially influenced the development and practice of intravenous anaesthesia. It opened the possibility of many new and exciting applications of perioperative anaesthetic care. More recent and current developments, such as open TCI (target-controlled infusion) and the availability of generic anaesthetic agents combined with modern infusion pumps, means that TCI can become a standard procedure in anaesthesia and is no longer just a research tool for specialists and enthusiasts. This review explains the fundamentals and applications of intravenous drug delivery by TCI and gives practice guidelines to successfully implement the technique into clinical practice. The aim is to provide a comprehensive reference based on clinically proven evidence.
authors.affiliation: Department of Perioperative Medicine, Golden Jubilee National Hospital, Beardmore Street, Clydebank, Glasgow, Scotland, UK. stefanschraag@btinternet.com
authors.forename: S
authors.initials: S
authors.lastname: Schraag
authors.forename: S
authors.initials: S
authors.lastname: Kreuer
authors.forename: J
authors.initials: J
authors.lastname: Bruhn
authors.forename: C
authors.initials: C
authors.lastname: Frenkel
authors.forename: S
authors.initials: S
authors.lastname: Albrecht
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage; D000771:Anesthesia, Intravenous / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016292:Procedural Sedation / Q000379:methods; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D007260:Infusion Pumps; D016343:Monitoring, Intraoperative; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D015742:Propofol