[Effects of Kang Gang Qian Granule (KGQG) on clinical and pathological features in chronic hepatitis B patients].
OBJECTIVE
To explore the efficacy of KGQG and its therapeutic mechanisms in chronic hepatitis B patients with liver fibrosis.


METHODS
57 chronic hepatitis B patients with liver fibrosis were randomly divided into two groups: 45 cases in KGQG group were treated by KGQG and routine medications; 12 cases in control group were treated by routine medications only. Serum liver function test results, PCIII, CIV, HA and liver biopsy results of these 57 patients were simultaneously collected and analyzed before and after this intervention.


RESULTS
KGQG group showed better efficacy over control group in liver function recovery, decrease of serum PCIII, CIV, HA levels and liver pathologic grades (P 0.05 or 0.01).


CONCLUSIONS
The KGQG could effectively ameliorate liver function and facilitate the inhibition and degradation of liver fibrosis in chronic hepatitis B patients, which may be developed as a novel therapeusis to treat this hard-to-cure disease.
Xiao
He-jie
HJ
Department of Infectious Diseases, The Third Clinical College, Three Gorges University, Hubei Province, Yichang City, 443002, China.
Shi
Ci-guo
CG
Zhang
Ai-ping
AP
Li
Ping
P
Fan
Zhong-shan
ZS
D000293:Adolescent; D000328:Adult; D024141:Collagen Type IV / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged
D024141:Collagen Type IV; D004365:Drugs, Chinese Herbal