title: Mechanical factors relate to pain in knee osteoarthritis.
abstract: BACKGROUND
  Pain experienced by people with knee osteoarthritis is related to psychosocial factors and damage to articular tissues and/or the pain pathway itself. Mechanical factors have been speculated to trigger this pain experience; yet mechanics have not been identified as a source of pain in this population. The purpose of this study was to identify whether mechanics could explain variance in pain intensity in people with knee osteoarthritis.
  
  
  METHODS
  Data from 53 participants with physician-diagnosed knee osteoarthritis (mean age=68.5 years; standard deviation=8.6 years) were analyzed. Pain intensity was reported on the Western Ontario and McMaster Universities Osteoarthritis Index. Mechanical measures included weight-bearing varus-valgus alignment, body mass index and isokinetic quadriceps torque. Gait analysis captured the range of adduction-abduction angle, range of flexion-extension angle and external knee adduction moment during level walking.
  
  
  RESULTS
  Pain intensity was significantly related to the dynamic range of flexion-extension during gait and body mass index. A total of 29% of the variance in pain intensity was explained by mechanical variables. The range of flexion-extension explained 18% of variance in pain intensity. Body mass index added 11% to the model. The knee adduction moment was unrelated to pain intensity.
  
  
  CONCLUSIONS
  The findings support that mechanical factors are related to knee osteoarthritis pain. Because limitations in flexion-extension range of motion and body size are modifiable factors, future research could examine whether interventions targeting these mechanics would facilitate pain management.
authors.affiliation: 1408 Elborn College, School of Physical Therapy, The University of Western Ontario, London, Ontario, Canada N6G 1H1. mmaly@uwo.ca
authors.forename: Monica R
authors.initials: MR
authors.lastname: Maly
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Costigan
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Olney
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000503:physiopathology*; D001696:Biomechanical Phenomena / Q000379:methods; D005260:Female; D005684:Gait; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology*; D010147:Pain Measurement; D016059:Range of Motion, Articular; D013223:Statistics as Topic