title: One new bufadienolide from Chinese drug "Chan'Su".
abstract: A new bufadienolide named 16beta-acetoxy-bufarenogin (1), together with six known bufadienolides, namely, 11alpha,12beta-dihydroxy-bufalin (2), bufotalin (3), hellebrigenin (4), desacetylbufotalin (5), gamabufotalin (6), and resibufagin (7) were isolated from Chan'Su. Of these, 2 was a new natural product. Their structures were elucidated by spectral methods. The cytotoxic activities in vitro of these compounds have been assayed against HeLa cell line. They all showed strong cytotoxic activities.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiao
authors.forename: Yong-Fu
authors.initials: YF
authors.lastname: Huang
authors.forename: Jia-Qing
authors.initials: JQ
authors.lastname: Cao
authors.forename: Yu-Zhi
authors.initials: YZ
authors.lastname: Zhou
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Qi
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002023:Bufo bufo; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002018:Bufanolides; C095591:chan su