title: RAGE in diabetic nephropathy.
abstract: As is diabetes itself, diabetic angiopathy is a multi-factorial disease. Advanced glycation endproducts (AGE) cause vascular cell derangement characteristic of diabetes, and this is mainly mediated by their interaction with receptor for AGE (RAGE). When made diabetic, RAGE-overexpressing transgenic mice exhibited exacerbation of the indices of nephropathy, and this was prevented by the inhibition of AGE formation. On the other hand, RAGE-deficient animals showed amelioration of diabetic nephropathy. Accordingly, AGE and RAGE should be regarded as environmental and cellular accounts and as a potential therapeutic target for diabetic nephropathy. In effect, substances that inhibit the formation of AGE, break preformed AGE, change metabolic flows away from glycation, antagonize RAGE, and capture RAGE ligands have been proven as effective remedies against this life-threatening disease.
authors.affiliation: Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. yamamoto@med.kanazawa-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Takuo
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hideto
authors.initials: H
authors.lastname: Yonekura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Munesue
authors.forename: Ai
authors.initials: A
authors.lastname: Harashima
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ooe
authors.forename: Sharmin
authors.initials: S
authors.lastname: Hossain
authors.forename: Hidehito
authors.initials: H
authors.lastname: Saito
authors.forename: Naho
authors.initials: N
authors.lastname: Murakami
mesh_terms: D000818:Animals; D003925:Diabetic Angiopathies / Q000378:metabolism / Q000628:therapy; D003928:Diabetic Nephropathies / Q000378:metabolism* / Q000628:therapy; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic