Changes in peripheral lymphocyte subsets in the type 1 diabetic dogs treated with insulin injections.
Plasma metabolites and peripheral lymphocyte subsets were measured in ten diabetic and ten control dogs to investigate their significances as indicators to evaluate immune states in the diabetic dogs. Diabetic dogs were treated with insulin injections, however their plasma glucose and fructosamine concentrations were significantly higher than those of the controls. There were no significant differences in counts of total white blood cells (WBC) and lymphocyte CD8(+) cells (cytotoxic T cells) between the control and the diabetic dogs. In the diabetic dogs, the counts of CD3(+) (T cells), CD4(+) (Helper T cells) and CD21(+) (B cells) cells and the peripheral lymphocytes CD4/CD8 ratio were significantly lower than those in the control dogs. We confirmed abnormality of lymphocyte subsets in insulin treated diabetic dogs and it may relate to depression of immunocompetence and high susceptibility to common infectious diseases.
Mori
Akihiro
A
Department of Veterinary Science, School of Veterinary Medicine, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan. D0608@nvlu.ac.jp
Sagara
Fumi
F
Shimizu
Sumire
S
Mizutani
Hisashi
H
Sako
Toshinori
T
Hirose
Hisashi
H
Yoshimura
Itaru
I
Uematsu
Yosuke
Y
Yamaguchi
Tomohiro
T
Arai
Toshiro
T
D000818:Animals; D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology; D004285:Dogs; D005260:Female; D019270:Fructosamine / Q000097:blood; D007328:Insulin / Q000494:pharmacology / Q000627:therapeutic use*; D016131:Lymphocyte Subsets / Q000187:drug effects*; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D019270:Fructosamine