Effect of porin loss on the activity of tigecycline against Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC-type beta-lactamases.
Tigecycline showed excellent in vitro activity against 50 clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases, plasmid-mediated AmpC-type beta-lactamases, or both. This activity was not affected by porin loss. Porin loss, however, did affect the activity of imipenem against strains that expressed both types of enzymes.
Conejo
M Carmen
MC
Department of Microbiology, School of Medicine, Seville 41009, Spain. conejo@us.es
Hernández
J Ramón
JR
Pascual
Alvaro
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D010957:Plasmids; D018272:Porins / Q000235:genetics / Q000502:physiology*; D000078304:Tigecycline; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
D000900:Anti-Bacterial Agents; D018272:Porins; D000078304:Tigecycline; D015378:Imipenem; D001618:beta-Lactamases; D008911:Minocycline