title: Use of drug-eluting stents in Brazil: the CENIC (National Registry of Cardiovascular Interventions) registry.
abstract: BACKGROUND
  Drug-eluting stents (DES) represent a major advance in the management of ischemic heart disease, but the extrapolation of favorable results from clinical trials to the real-world practice has been criticized.
  
  
  OBJECTIVE
  To assess the use of DES in Brazil between 2000 and 2005.
  
  
  METHODS
  Using the database of the National Registry of Cardiovascular Interventions (CENIC - Central Nacional de Intervenções Cardiovasculares) of the Brazilian Society of Hemodynamics and Interventional Cardiology (SBHCI - Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista), all PCI procedures with DES implantation performed between 2000 and 2005 were analyzed. The groups were divided into the following biennia: 2000-2001(A), 2002-2003 (B), and 2004-2005 (C), and patient's clinical and angiographic characteristics were compared, as well as their short-term clinical outcome. Statistical analyses were performed using the chi-square test or ANOVA, and p values of less than 0.05 were considered to be statistically significant.
  
  
  RESULTS
  A total of 154,406 PCI procedures were studied, and DES was used in 10,426 (7%) interventions. A progressive and statistically significant increase was found in the use of DES during the period studied: 0.14% from 2000 to 2001, 5% from 2002 to 2003, and 14% from 2004 to 2005 (p < 0.0001). After 2001, there was an increase in success rates (96.58% in 2000-2001 (A), 99.69% in 2002-2003 (B), and 99.56% in 2004-2005 (C), A x B with p < 0.001; B x C with p = 0.015) and a decrease in hospital mortality rates (1.59% in group A, 0.38% in group B, and 0.66% in group C, with p = 0.59 for A x B and p < 0.0001 for B x C).
  
  
  CONCLUSIONS
  In Brazil, the use of drug-eluting stents increased significantly during recent years, resulting in higher success rates and lower hospital mortality.
authors.affiliation: Central Nacional de Intervenções Cardiovasculares, Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista, São Paulo, SP - Brazil.
authors.forename: Cristiano O
authors.initials: CO
authors.lastname: Cardoso
authors.forename: Alexandre S
authors.initials: AS
authors.lastname: de Quadros
authors.forename: Luiz A
authors.initials: LA
authors.lastname: Mattos
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gottschall
authors.forename: Rogério E
authors.initials: RE
authors.lastname: Sarmento-Leite
authors.forename: José A
authors.initials: JA
authors.lastname: Marin-Neto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001938:Brazil / Q000453:epidemiology; D016009:Chi-Square Distribution; D002648:Child; D054855:Drug-Eluting Stents / Q000009:adverse effects / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality / Q000628:therapy*; D012042:Registries; D013997:Time Factors; D016896:Treatment Outcome