title: [Case of atopic myelitis with acute onset and atypical distribution of spinal cord lesions].
abstract: A 23-year-old woman was admitted to our department because of gait disturbance, sensory impairment in the lower limbs, and sphincter disturbance, all of which had been developing within 24 hours before admission. Neurological examination disclosed symmetric muscle weakness, sensory impairment, and diminished tendon reflexes in the lower limbs. The urinary bladder was hypoactive, and the anal tone was reduced. The spinal cord MRI performed on the day of admission revealed swelling of the epiconus. The CSF findings were not remarkable, except for the elevated levels of IgE (8 IU/ml) and MBP (7.8 ng/ml). Besides, there was a marked increase in the serum mite-specific IgE titers. Collectively, we made a diagnosis of atopic myelitis. She was treated with steroid pulse therapy and plasma exchange, which led to a significant amelioration of her neurological manifestations. The repeat MRI carried out on the 21st day of her admission displayed several foci scattered in the lumbar and sacral spinal cord segments, which exhibited high intensity signals on the T2-weighted images. The values of IgE and albumin in the CSF and serum raised the possibility of intrathecal IgE synthesis. We measured her CSF IgE levels at several time points during admission. The temporal profile of her CSF IgE levels was not correlated with that of her neurological disabilities.
authors.affiliation: Department of Neurology, National Hospital Organization Tokyo Medical Center.
authors.forename: Kohji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Mamoru
authors.initials: M
authors.lastname: Shibata
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Komagamine
authors.forename: Yoko
authors.initials: Y
authors.lastname: Morita
authors.forename: Shintaro
authors.initials: S
authors.lastname: Gomi
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003876:Dermatitis, Atopic / Q000150:complications*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage; D008925:Mites / Q000276:immunology; D009187:Myelitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D010951:Plasma Exchange; D020551:Pulse Therapy, Drug; D013116:Spinal Cord / Q000276:immunology / Q000473:pathology*
chemical_list: D015415:Biomarkers; D007073:Immunoglobulin E; D008775:Methylprednisolone