Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.
Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma.
Flavahan
Nicholas A
NA
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building R370, 720 Rutland Avenue, Baltimore, MD 21205, USA.
D003080:Cold Temperature / Q000009:adverse effects; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D011928:Raynaud Disease / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology*; D017382:Reactive Oxygen Species; D011941:Receptors, Adrenergic / Q000502:physiology; D012595:Scleroderma, Systemic / Q000150:complications / Q000503:physiopathology*; D015398:Signal Transduction; D012881:Skin Temperature / Q000502:physiology; D054460:rho-Associated Kinases / Q000502:physiology
D017382:Reactive Oxygen Species; D011941:Receptors, Adrenergic; D054460:rho-Associated Kinases