Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats.
IL-1beta, TNF-alpha, cytokine-induced neutrophil chemoattractant-2alpha/beta, and IL-10 measurements were performed in elicited peritoneal cells from control, diabetic, and insulin-treated diabetic rats. Production/liberation of these cytokines was decreased in elicited peritoneal cells from diabetic rats. These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states.
Alba-Loureiro
Tatiana Carolina
TC
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil. tatica@icb.usp.br
Pithon-Curi
Tania Cristina
TC
Curi
Rui
R
D000818:Animals; D019743:Chemokines, CXC / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D016753:Interleukin-10 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism; D010537:Peritoneum / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D019743:Chemokines, CXC; C513294:Cxcl3 protein, rat; D016207:Cytokines; D007328:Insulin; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D006003:Glycogen