[Toxicity attenuation and efficacy potentiation effects of Fu Zheng Yang Yin Decoction with HIFU on the experimental model of VX2 cancer in rabbits' liver].
OBJECTIVE
To investigate the toxicity attenuation and efficacy potentiation effects of Fu Zheng Yang Yin Decoction with HIFU on the experimental model of VX2 liver cancer in rabbits.


METHODS
The rabbits were all transplanted with VX2 cancer on livers. The 30 rabbits were divided into three groups: HIFU group (HIFU therapy), Combination group (HIFU + Fu Zheng Yang Yin decoction), Control group (without any treatment). Each group involved 10 rabbits. After treatment, the volume of the tumor was observed by sonography. Metastases, pathological changes, Immunoglobulin, ALT were also observed.


RESULTS
After treatment, ALT and temperature of Combination group and HIFU group were lower than Control group (P < 0.05). The tumor volume of Combination group and HIFU group showed significant difference with control group (P < 0.05). Immunoglobulin of HIFU group and Combination group increased, that of Control group decreased. One month after treatment, all animals were dissected. Combination group had no lung transferred, HIFU group had 2 lung transferred, all of control group had lung transferred.


CONCLUSIONS
The combination therapy of Fu Zheng Yang Yin decoction with HIFU can effectively inhibited VX2 cancer growth in rabbit's liver. Fu Zheng Yang Yin decoction can reduce side-effect, improve immune function, and has special effects of toxicity attenuation and efficacy potentiation.
Pan
Jin-yao
JY
First People's Hospital of Guangzhou, Guangzhou 510180, China.
Liu
Yan-hong
YH
Yang
Qi-hua
QH
Jia
Lin
L
Ma
Jun
J
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008297:Male; D008517:Phytotherapy / Q000379:methods; D011817:Rabbits; D011897:Random Allocation; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C530395:fu zheng yang yin; D000410:Alanine Transaminase