Steroidal glycosides from the roots of Cynanchum amplexicaule Sieb. et Zucc.
Seven new steroidal glycosides (amplexicosides A (4), B (7), C (8), D (9), E (10), F (11), and G (12)), along with six known compounds (cynatratoside A (1), tylophoside A (2), cynatratoside B (3), glaucogenin A (5), glaucoside A (6), and hancoside A (13)) were isolated from the 95% ethanol extract of the roots of Cynanchum amplexicaule (Sieb. et Zucc.). Their structures were determined based on spectral and chemical evidence. Compound 12 has a 14, 15-secopregnane-type skeleton aglycone, which has not been reported in literature.
Chen
Huan
H
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, People's Republic of China.
Xu
Nan
N
Zhou
Yuzhi
Y
Qiao
Li
L
Cao
Jiaqing
J
Yao
Yao
Y
Hua
Huiming
H
Pei
Yuehu
Y
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D031105:Cynanchum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
D006027:Glycosides; D013256:Steroids