[The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats].
We have investigated effects of Mildronate, gamma-butyrobetaine (GBB) and their combination ("Neomildronate") on the plasma levels of thyroid gland hormones and some intermediates of basal metabolism (free fatty acids, triglycerides, glucose) in rats with different dysfunctions of thyroid gland, including idiopathic hyperfunction and hypofunction induced by propylthiouracil or L-carnitin administration. Histological investigation of the thyroid gland was also performed. Intraperitoneal injections of Mildronate (150 mg/kg) during 20 days to Wistar male rats with elevated level of thyroid hormones and basal metabolism normalized thyroxine level and parameters of lipid metabolism. Mildronate, GBB and their combination did not affect the natural resurgence of rats with experimental hypofunction induced by propylthiouracil or L-carnitin administration. The possible biochemical role of given treatment in regulation of thyroid gland function is discussed.
Sharipova
E M
EM
Salna
E V
EV
Dzintare
M I
MI
Lauberte
L I
LI
Sjakste
N I
NI
Gordiushina
V S
VS
Kalvinsh
I I
II
D000818:Animals; D013956:Antithyroid Agents / Q000633:toxicity; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002331:Carnitine / Q000494:pharmacology* / Q000633:toxicity; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D011441:Propylthiouracil / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013959:Thyroid Diseases / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology; D013974:Thyroxine / Q000097:blood*; D014803:Vitamin B Complex / Q000633:toxicity
D013956:Antithyroid Agents; D002317:Cardiovascular Agents; D008763:Methylhydrazines; D014803:Vitamin B Complex; D001622:Betaine; C002889:gamma-butyrobetaine; D011441:Propylthiouracil; C050147:3-(2,2,2-trimethylhydrazine)propionate; D013974:Thyroxine; D002331:Carnitine