In vivo cartilage contact deformation of human ankle joints under full body weight.
Quantitative data on in vivo deformation of articular cartilage is important for understanding the articular joint function and the etiology of degenerative joint diseases such as osteoarthritis. This study experimentally determined the in vivo cartilage thickness distribution and articular cartilage contact strain distribution in human ankle joints under full body weight loading conditions using a combined dual fluoroscopic and magnetic resonance imaging technique. The average cartilage thickness with the joint non-weight bearing was found to be 1.43 mm +/- 0.15 mm and 1.42 mm +/- 0.18 mm in the distal tibial and proximal talar cartilage layers, respectively. During weight bearing on a single leg, the strain distribution data revealed that 42.4% +/- 15.7% of the contact area had contact strain higher than 15% in the ankle joint. Peak cartilage contact strain reached 34.5% +/- 7.3%. This quantitative data on in vivo human cartilage morphology and deformation demonstrated that the cartilage may undergo large deformations under the loading conditions experienced in human ankle joints during daily activities. The in vivo cartilage contact deformation can be used as displacement boundary conditions in three-dimensional (3D) finite element models of the joint to calculate in vivo 3D articular cartilage contact stress/strain distributions.
Wan
Lu
L
Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, Massachusetts 02114, USA.
de Asla
Richard J
RJ
Rubash
Harry E
HE
Li
Guoan
G
D000328:Adult; D000843:Ankle Joint / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005471:Fluoroscopy / Q000379:methods* / Q000592:standards; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D012016:Reference Values; D013314:Stress, Mechanical; D013628:Talus; D013977:Tibia; D016474:Weight-Bearing / Q000502:physiology*