title: Vitamin D regulation of cathelicidin in the skin: toward a renaissance of vitamin D in dermatology?
abstract: 1,25-Dihydroxyvitamin D(3), the active form of vitamin D, is a major regulator of the expression of the cationic antimicrobial peptide cathelicidin, not only in monocytes but also in epidermal keratinocytes. The involvement of cathelicidin in wound healing and skin diseases as diverse as psoriasis, rosacea, and atopic dermatitis may create new opportunities for the use of vitamin D in dermatology.
authors.affiliation: Department of Dermatology, University Hospital Leuven, Belgium. Siegfried.Segaert@med.kuleuven.be
authors.forename: Siegfried
authors.initials: S
authors.lastname: Segaert
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D002117:Calcitriol / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D014807:Vitamin D; D002117:Calcitriol; D054804:Cathelicidins