title: Inappropriate gonadotropin secretion in polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Academic tertiary center.
  
  
  METHODS
  A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251).
  
  
  METHODS
  None.
  
  
  METHODS
  Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS.
  
  
  RESULTS
  The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects.
  
  
  CONCLUSIONS
  The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan.
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Hsu
authors.forename: Tsan-Hon
authors.initials: TH
authors.lastname: Liou
authors.forename: So-Jung
authors.initials: SJ
authors.lastname: Liang
authors.forename: Hung-Wen
authors.initials: HW
authors.lastname: Su
authors.forename: Chien-Hua
authors.initials: CH
authors.lastname: Wu
authors.forename: Chun-Sen
authors.initials: CS
authors.lastname: Hsu
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D006062:Gonadotropins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone