Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes.
Horizontal transfer of the mutated ftsI gene from beta-lactamase-nonproducing ampicillin-resistant (BLNAR) Haemophilus influenzae to a susceptible strain was examined in vitro under selection with nine oral beta-lactams (ampicillin, amoxicillin, cefprozil, cefuroxime, cefpodoxime, cefdinir, cefcapene, cefditoren, and tebipenem). Compared to the penicillins and the carbapenem, the cephalosporins showed a wide selection window for the genetic transfer.
Takahata
Sho
S
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. sho_takahata@meiji.co.jp
Kato
Yoshihisa
Y
Sanbongi
Yumiko
Y
Maebashi
Kazunori
K
Ida
Takashi
T
D000667:Ampicillin / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology; D022761:Gene Transfer, Horizontal; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D046915:Penicillin-Binding Proteins / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology*; D000097670:Cefprozil
D000667:Ampicillin; D001426:Bacterial Proteins; D015780:Carbapenems; D000077525:Cefdinir; D002511:Cephalosporins; D046915:Penicillin-Binding Proteins; D047090:beta-Lactams; D000097670:Cefprozil; C073460:cefditoren; C500135:tebipenem