Differential expression of HOX genes upon activation of leukocyte sub-populations.
The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expression in resting and activated lymphocytic and monocytic subpopulations. This has revealed distinct patterns of expression between different cell types and resting and activated states. (Main category A: Erythrocytes, Leukocytes and Hematopoiesis, subcategory: 8: Lymphocytes).
Morgan
Richard
R
Postgraduate Medical School, University of Surrey, Guildford, Surrey, GU2 7WG, UK. r.morgan@surrey.ac.uk
Whiting
Karen
K
D016175:B-Lymphocyte Subsets / Q000378:metabolism*; D020869:Gene Expression Profiling; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D018398:Homeodomain Proteins