Cellular AATF gene: armour against HIV-1.
Outcome of HIV-1 infection at the cellular level is decided by the orchestrated balance that exists between cellular nucleic acid-based adaptive immune mechanism involving non-coding micro RNAs (miRNAs) and offensive tactics of HIV-1 to suppress this host cellular immunity. In this context, the review explains the importance of a novel miRNA encoded exclusively and conspicuously by HIV-1 genome that has the ability to specifically target cellular AATF gene recognized to play a crucial role in the maintenance of adaptive immunity at nucleic acid level against HIV-1 invasion.
Kaul
Deepak
D
Molecular Biology Unit,Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India. dkaul_24@hotmail.com
D017209:Apoptosis / Q000235:genetics / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins / Q000276:immunology*; D002468:Cell Physiological Phenomena; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D012097:Repressor Proteins / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology*
C402637:AATF protein, human; D051017:Apoptosis Regulatory Proteins; D035683:MicroRNAs; D012097:Repressor Proteins; D014157:Transcription Factors