Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide.
Current chemotherapy treatment of solid tumors is limited due to a lack of specific delivery of the drugs to the tumor, leading to systemic toxicity. Therefore, it is necessary to develop targeted cancer therapies and tumor-targeted drug carriers. The authors review the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutics. The authors searched Medline for articles concerning the application of ELP as a drug delivery vector for small molecule drugs and therapeutic peptides. ELP has been demonstrated to be a promising thermally targeted carrier. Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics.
Raucher
Drazen
D
University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA. draucher@biochem.umsmed.edu
Massodi
Iqbal
I
Bidwell
Gene L
GL
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004549:Elastin / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D013696:Temperature
D000970:Antineoplastic Agents; D010455:Peptides; D004549:Elastin