Schizophrenia genetics: the search for a hard lead.
OBJECTIVE
To describe the rationale for searching for genes for schizophrenia, prior efforts via candidate gene association and genomewide linkage studies, and to set the stage for the numerous genomewide association studies that will emerge by the end of 2008.


RESULTS
Genomewide association studies have identified dozens of new and previously unsuspected candidate genes for many biomedical disorders. At least seven new studies of approximately 20,000 cases plus controls are expected to be completed by the end of 2008.


CONCLUSIONS
Current results have few implications for clinical practice or research, and it is possible that this recommendation could be dramatically different in a year.
Sullivan
Patrick F
PF
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599-7264, USA. pfsulliv@med.unc.edu
D015870:Gene Expression / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers