Inhibitory feature of the proprotein convertases prosegments.
The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
Bontemps
Yannick
Y
INSERM U 716, Equipe AVENIR, Laboratoire de Pharmacologie Expérimentale et Clinique, Institut de Génétique Moléculaire, Paris ,75010, France.
Lapierre
Marion
M
Siegfried
Geraldine
G
Calvo
Fabien
F
Khatib
Abdel-Majid
AM
D000595:Amino Acid Sequence; D010446:Peptide Fragments / Q000494:pharmacology; D043484:Proprotein Convertases / Q000737:chemistry / Q000494:pharmacology*; D017434:Protein Structure, Tertiary
D010446:Peptide Fragments; D043484:Proprotein Convertases