title: Rosiglitazone maleate 0.25-hydrate: a pseudopolymorphic form.
abstract: The present 0.25-hydrated form of rosiglitazone maleate [systematic name: (+/-)-2-({2-[2,4-dioxo-1,3-thiazolidin-5-ylmethyl)phenoxy]ethyl}methylamino)pyridinium maleate 0.25-hydrate], C(18)H(20)N(3)O(3)S(+) x C(4)H(3)O(4)(-) x 0.25 H(2)O, is a racemate with two independent moieties in the unit cell. Although the cation geometry does not differ substantially from that in the previously reported hydrochloride, the packing is quite different, the main feature being the formation of hydrogen-bonded tetramers, linked head-to-tail into weakly interacting chains.
authors.affiliation: Agencia Córdoba Ciencia, Córdoba, Argentina. scuffini@yahoo.com
authors.forename: Silvia L
authors.initials: SL
authors.lastname: Cuffini
authors.forename: Sonia
authors.initials: S
authors.lastname: Faudone
authors.forename: Maribel
authors.initials: M
authors.lastname: Ferro
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Garland
authors.forename: Ricardo
authors.initials: R
authors.lastname: Baggio
mesh_terms: D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D000077154:Rosiglitazone; D013237:Stereoisomerism; D045162:Thiazolidinediones / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D045162:Thiazolidinediones; D014867:Water; D000077154:Rosiglitazone