title: [Mechanism of action of Nizhne-Ivkinskaya 2K sulfate-calcium mineral water in combined treatment of acid-dependent gastrointestinal diseases].
abstract: OBJECTIVE
  To study efficacy of drinking mineral water (MW) nizhne-ivkinskaya 2K in combined sanatorium treatment of gastrointestinal acid-dependent diseases (ADD) and the role of endogenic modulators of M-cholinoreactivity in pathogenesis of ADD.
  
  
  METHODS
  General condition of the patients, gastric pH and peristalsis (computer system Gastrolog-M), gastric and gall bladder motility (Aloka SSD 1100), hepatic function (by bilirubin and AST and ALT activity), lipid spectrum (including LDLP and HDLP) and M-cholinomodulating activity of the blood serum (by biomethod) were examined in 134 subjects: 20 healthy subjects and 114 patients with ADD.
  
  
  RESULTS
  In ADD, gastric juice acidity is high, gastric and gall bladder motility is low, total cholesterol and LDLP cholesterol are elevated, M-cholinoblocking activity of the blood serum is reduced 10-fold. Intake of nizhne-ivkinskaya 2K mineral water for 21 days improved the patients' health, normalized gastric pH, motility of the stomach and gall bladder, reduced content of LDLP and restored M-cholinoblocking serum activity.
  
  
  CONCLUSIONS
  ADD development is thought to result from excessive vagus effect due to elevated blood level of lysophosphatidylcholine (LPC). In certain concentrations it can enhance efficacy of M-cholinergic impacts on gastric cells. Reduction of LDLP content due to intake of the mineral water leads to normalization of M-cholinergic impacts on gastric cells.
authors.forename: P V
authors.initials: PV
authors.lastname: Guliaev
authors.forename: T V
authors.initials: TV
authors.lastname: Pomaskina
authors.forename: A A
authors.initials: AA
authors.lastname: Kunshin
authors.forename: L A
authors.initials: LA
authors.lastname: Chervotkina
authors.forename: S F
authors.initials: SF
authors.lastname: Guliaeva
authors.forename: V I
authors.initials: VI
authors.lastname: Tsirkin
mesh_terms: D002133:Calcium Sulfate / Q000032:analysis*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005767:Gastrointestinal Diseases / Q000178:diet therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters / Q000032:analysis / Q000627:therapeutic use*; D012426:Russia; D016896:Treatment Outcome
chemical_list: D008900:Mineral Waters; D002133:Calcium Sulfate