title: Deconstructing media coverage of trastuzumab (Herceptin): an analysis of national newspaper coverage.
abstract: OBJECTIVE
  To explore and critically describe the content and main narratives of UK national daily newspaper coverage of trastuzumab (Herceptin).
  
  
  METHODS
  We used the NewsBank database to search eight national daily newspapers, and their Sunday equivalents, retrospectively from 19 February 2006 back to the earliest mention of trastuzumab or Herceptin (19 May 1998). Setting UK national newspapers.
  
  
  METHODS
  To be eligible for inclusion, articles had to contain at least three sentences about trastuzumab. Articles that focused on the financial performance of companies associated with the drug were excluded from the analysis. For each included article, we extracted bibliographic details and data, and independently rated the reporting slant towards trastuzumab and, where relevant, the reporting slant towards access to treatment.
  
  
  RESULTS
  We identified 361 articles that met the study inclusion criteria. The proprietary name of Herceptin was always used, with only eight articles mentioning the generic alternative. 294/361 included articles (81.5%) were rated as being positive towards trastuzumab, the remainder rated as neutral. Access to trastuzumab treatment was the main narrative running across included articles and reports of individual patients seeking treatment featured prominently throughout. In 208/361 of included articles (57%) the reporting slant towards access to trastuzumab treatment was rated as negative. 178/361 of included articles (49.3%) mentioned licensing, but rarely mentioned that licensing processes can only occur when the manufacturer applies for a licence. Only a minority of articles mentioned that the drug had to be licensed before it could be subject to the NICE approval process.
  
  
  CONCLUSIONS
  Newspaper coverage of trastuzumab has been characterized by uncritical reporting. Journalists (and consumers) should be more questioning when confronted with information about new drugs and of the motives of those who seek to set the news agenda.
authors.affiliation: Centre for Reviews and Dissemination, University of York, UK. pmw7@york.ac.uk
authors.forename: Paul M
authors.initials: PM
authors.lastname: Wilson
authors.forename: Alison M
authors.initials: AM
authors.lastname: Booth
authors.forename: Alison
authors.initials: A
authors.lastname: Eastwood
authors.forename: Ian S
authors.initials: IS
authors.lastname: Watt
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000191:economics; D016527:Drug Costs; D005260:Female; D006801:Humans; D009524:Newspapers as Topic; D012189:Retrospective Studies; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068878:Trastuzumab