Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers.
Littorachalcone (1) and diacid 10 were synthesized by direct routes. The antibacterial activity of 1, 10 and synthetic precursors were evaluated. Dialdehyde 3a showed potent antibacterial activity.
Kraus
George A
GA
Department of Chemistry, Iowa State University, Ames, IA 50011, USA. gakraus@iastate.edu
Kumar
Ganesh
G
Phillips
Gregory
G
Michalson
Kris
K
Mangano
Maria
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002599:Chalcone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D010647:Phenyl Ethers; D002599:Chalcone