Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate.
Herein we report the 1.15 A X-ray crystal structure of a short alpha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived alpha-helix truly resembles the structure of canonical alpha-helices and provides unequivocal support for our helix nucleation strategy.
Liu
Jie
J
Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.
Wang
Deyun
D
Zheng
Qi
Q
Lu
Min
M
Arora
Paramjit S
PS
D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary
D010455:Peptides