Fibrosis in systemic sclerosis.
This article reviews current understanding of the pathophysiology of fibrosis in systemic sclerosis. It highlights recent discoveries, insights, and emerging research, and potential opportunities for the development of targeted antifibrotic therapies.
Varga
John A
JA
Division of Rheumatology, Northwestern University Feinberg School of Medicine, McGaw 2300, 240 East Huron Street, Chicago IL 60611-2909, USA. j-varga@northwestern.edu
Trojanowska
Maria
M
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000502:physiology; D005355:Fibrosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D051379:Mice; D020286:Pericytes / Q000502:physiology; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000503:physiopathology*
D003094:Collagen