Structural and biological behaviors of some nonionic Schiff-base amphiphiles and their Cu(II) and Fe(III) metal complexes.
Novel series of nonionic Schiff bases was synthesized and characterized using microelemental analysis, FTIR and (1)H NMR spectra. These Schiff bases and their complexes with Cu and Fe have been evaluated for their antibacterial activity against bacterial species such as Staphylococcus aureus, Pseudomonas aureus, Candida albi, Bacillus subtilis and Escherichia coli and their fungicidal activity against Aspcrgillus niger and Aspcrgillus flavus. The results of the biocidal activities showed high potent action of the synthesized Schiff bases towards both bacteria and fungi. Furthermore, complexation of these Schiff bases by Cu(II) and Fe(III) show the metal complexes to be more antibacterial and antifungal than the Schiff bases. The results were correlated to the surface activity and the transition metal type. The mode of action of these complexes was discussed.
Negm
Nabel A
NA
Applied Surfactant Laboratory, Petrochemicals Department, Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo, Egypt. nabelnegm@hotmail.com
Zaki
Mohamed F
MF
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011549:Pseudomonas / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005290:Ferric Compounds; D012545:Schiff Bases; D003300:Copper