title: Minimising blood loss and transfusion requirements in hepatic resection.
abstract: BACKGROUND
  Substantial blood loss and the requirement for blood transfusion remain major considerations for hepatic surgeons. We analysed the impact of a systematic protocol aimed at reducing intraoperative blood loss and homologous blood (HB) transfusion associated with hepatic resection.
  
  
  METHODS
  Prospective clinical data were collected from 151 elective liver resections performed during the period between 1980 and 1999. Further data directly related to blood loss and anaesthesia were retrospectively collected from the anaesthetic intra-operative record. Strategies implemented in 1991 included preoperative autologous blood donation, low central venous pressure anaesthesia, aprotinin administration, ultrasonic dissection, hepatic vascular inflow occlusion and a Cell Saver. Blood loss and transfusion requirements were studied before and after the implementation of these strategies.
  
  
  RESULTS
  There was no difference in the patient demographics, indications for operation or the scope of resections in the two time periods evaluated. Blood-saving strategies resulted in decreased estimated blood loss (4500 mL vs. 1000 mL p<0.001). In addition, the number of patients requiring transfusion decreased (91.8% vs. 25.5% respectively, p<0.001) and the mean number of units of HB transfusion was lower (I 3.7 vs. 2.3, p<0.001). Morbidity and mortality were also decreased (57.1% vs. 25.5%, p<0.001 and 10.2% and 4.9% p<0.001, respectively). No complications directly referrable to low CVP anesthesia were identified.
  
  
  CONCLUSIONS
  Systematic implementation of strategies designed to control blood loss are effective and may reduce morbidity and mortality associated with hepatic resections.
authors.affiliation: Division of General Surgery and Surgical Oncology, Department of Anaesthesia and Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Canada.
authors.forename: Luke L
authors.initials: LL
authors.lastname: Bui
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Smith
authors.forename: Mark
authors.initials: M
authors.lastname: Bercovici
authors.forename: John P
authors.initials: JP
authors.lastname: Szalai
authors.forename: Sherif S
authors.initials: SS
authors.lastname: Hanna