title: Use of a topical emulsion for wound healing.
abstract: Treatment of skin trauma following removal of actinic keratoses and skin cancer lesions and following radiation therapy for breast cancer is an often under-treated problem compared to the primary condition. However, skin trauma can cause patients significant discomfort, pain, and loss of quality of life. Palliative treatments such as lotions and ointments may help soothe the skin trauma, but helping the healing process is the best way to treat the wound and relieve patients of their discomfort. In clinical trials, the use of Biafine, a topical emulsion, promoted wound healing following these clinical situations by increasing the number of macrophages recruited to a wound and thus enhancing healing. This topical emulsion has also been proven to be soothing for the patient. This review will discuss the molecular mechanisms of wound healing and the uses of Biafine in the treatment of skin damage caused by procedures for various conditions such as actinic keratosis, skin cancer lesions, and radiation dermatitis.
authors.affiliation: Department of Dermatology, University of Colorado, USA. denverskindoc@yahoo.com
authors.forename: Joel L
authors.initials: JL
authors.lastname: Cohen
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Jorizzo
authors.forename: Leon H
authors.initials: LH
authors.lastname: Kircik
mesh_terms: D000284:Administration, Oral; D004655:Emulsions; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use*; D008264:Macrophages; D014945:Wound Healing
chemical_list: C423724:Biafine; D004655:Emulsions; D008055:Lipids