title: Serum complement 3 (C3) and complement 4 (C4) level in febrile neutropenia patients at Dr. Kariadi Hospital, Semarang and Dr. Moewardi Hospital, Surakarta.
abstract: OBJECTIVE
  to identify the serum complement 3 (C3) and complement 4 (C4) level in febrile neutropenia and non-febrile neutropenia patients.
  
  
  METHODS
  this is a cross-sectional prospective study. Samples were collected from patients with febrile neutropenia as sample group and patients with neutropenia but without fever as control. Both groups were tested for serum complement 3 and complement 4 level, and the data were analyzed using student T-test.
  
  
  RESULTS
  from 37 neutropenia patients, 23 were classified as febrile neutropenia group and 14 in non-febrile neutropenia as control group. Total mean neutrophil count was 653.22/ml serum in sample group and 594.36/ml serum in control group (p=0.575). Mean C3 level was 95.74 ug/dl in sample group and 130.00 ug/dl in control group, showing significant difference with p=0.031. The mean serum C4 level was 34.13 ug/ml in sample group and 34.00 ug/dl in control group, the difference is not significant with p=0.98. When sample C3 and C4 data were combined, the total level was 125.61 ug/ml, which was significantly lower than the total C3 and C4 in control group 184.07 ug/dl. (p=0.04).
  
  
  CONCLUSIONS
  in febrile neutropenia there is significant decrease of serum C3 level compared to non-febrile neutropenia. Serum C4 level in febrile neutropenia group is lower than the non-febrile neutropenia group, but the difference is not significant.
authors.affiliation: Department of Internal Medicine UNS School of Medicine/RSUD Dr. Moewardi, Jl. Kol. Sutarto 132, Surakarta. papdisolo@yahoo.com
authors.forename: Suradi
authors.initials: S
authors.lastname: Maryono
authors.forename: A
authors.initials: A
authors.lastname: Guntur
authors.forename: C
authors.initials: C
authors.lastname: Suharti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D015941:Complement Hemolytic Activity Assay; D003430:Cross-Sectional Studies; D005260:Female; D005334:Fever / Q000097:blood*; D006761:Hospitals; D006801:Humans; D007214:Indonesia; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood* / Q000503:physiopathology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
chemical_list: D003176:Complement C3; D003181:Complement C4