title: Doppler ultrasound compatible plastic material for use in rigid flow models.
abstract: A technique for the rapid but accurate fabrication of multiple flow phantoms with variations in vascular geometry would be desirable in the investigation of carotid atherosclerosis. This study demonstrates the feasibility and efficacy of implementing numerically controlled direct-machining of vascular geometries into Doppler ultrasound (DUS)-compatible plastic for the easy fabrication of DUS flow phantoms. Candidate plastics were tested for longitudinal speed of sound (SoS) and acoustic attenuation at the diagnostic frequency of 5 MHz. Teflon was found to have the most appropriate SoS (1376 +/- 40 m s(-1) compared with 1540 m s(-1) in soft tissue) and thus was selected to construct a carotid bifurcation flow model with moderate eccentric stenosis. The vessel geometry was machined directly into Teflon using a numerically controlled milling technique. Geometric accuracy of the phantom lumen was verified using nondestructive micro-computed tomography. Although Teflon displayed a higher attenuation coefficient than other tested materials, Doppler data acquired in the Teflon flow model indicated that sufficient signal power was delivered throughout the depth of the vessel and provided comparable velocity profiles to that obtained in the tissue-mimicking phantom. Our results indicate that Teflon provides the best combination of machinability and DUS compatibility, making it an appropriate choice for the fabrication of rigid DUS flow models using a direct-machining method.
authors.affiliation: Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
authors.forename: Emily Y
authors.initials: EY
authors.lastname: Wong
authors.forename: Meghan L
authors.initials: ML
authors.lastname: Thorne
authors.forename: Hristo N
authors.initials: HN
authors.lastname: Nikolov
authors.forename: Tamie L
authors.initials: TL
authors.lastname: Poepping
authors.forename: David W
authors.initials: DW
authors.lastname: Holdsworth
mesh_terms: D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004867:Equipment Design; D005240:Feasibility Studies; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008954:Models, Biological; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging; D010969:Plastics; D011138:Polytetrafluoroethylene; D011673:Pulsatile Flow; D018608:Ultrasonography, Doppler / Q000379:methods
chemical_list: D010969:Plastics; D011138:Polytetrafluoroethylene