Glycosidic constituents of the tubers of Gymnadenia conopsea.
Ten minor new glycosidic constituents (1- 10), together with 10 known compounds, have been isolated from a neuroprotective fraction of an ethanolic extract of the tubers of Gymnadenia conopsea. The structures of 1-10 were determined using spectroscopic and chemical methods. The compounds isolated were evaluated for activity in in vitro assays for acetylcholine esterase and monoamine oxidase inhibitory activities.
Zi
Jiachen
J
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
Li
Shuai
S
Liu
Mingtao
M
Gan
Maoluo
M
Lin
Sheng
S
Song
Weixia
W
Zhang
Yanling
Y
Fan
Xiaona
X
Yang
Yongchun
Y
Zhang
Jianjun
J
Shi
Jiangong
J
Di
Duolong
D
D000818:Animals; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*; D035281:Plant Tubers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D008996:Monoamine Oxidase Inhibitors