[Changes in parameters of orthogonal ECG in hypertensive patients given combined antihypertensive treatment].
OBJECTIVE
To evaluate changes in parameters of orthogonal ECG in hypertensive patients on trandolapril+verapamil combination.


METHODS
Eighteen patients before and after 8-week therapy were examined using orthogonal ECG and 24-h monitoring of blood pressure. Computer processing of orthogonal ECG was made with calculation of some vectorcardiography (VCG) and d mapping parameters. Also, 24-h blood pressure monitoring was made.


RESULTS
8-week therapy significantly reduced mean diurnal and nocturnal systolic and diastolic blood pressure (SBP, DBP), improved their variability. In patients with VCG signs of left ventricular hypertrophy the treatment significantly diminished some VCG parameters. A direct correlation was found between initial diurnal SBP variability and SQRSxyz, SQRSxz; dynamics of nocturnal SBP variability and dynamics of SQRSxyz, SQRSxz and Rx+Sz (r = 0.7; p < 0.05). A direct correlation was between dynamics of SBP and IADI (r = 0.7; p < 0.05).


CONCLUSIONS
Hypertensive patients treated with a fixed combination trandolapril/verapamil exhibit a positive trend not only in parameters of 24-h monitoring of blood pressure but also in parameters of orthogonal ECG.
Sakhnova
T A
TA
Blinova
E V
EV
Chikhladze
N M
NM
Samedova
Kh F
KhF
Kolos
I P
IP
Chazova
I E
IE
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D018780:Body Surface Potential Mapping / Q000187:drug effects*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D001330:Electronic Data Processing; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000959:Antihypertensive Agents