title: Impact of different texture of polypropylene mesh on the inflammatory response.
abstract: Over the past decade, hernia surgery has undergone a considerable transformation with the use of prosthetic materials. The most used polypropylene meshes induce a rapid acute inflammatory response followed by chronic foreign body reaction. Many factors influence this response such as density, size, physical characteristics, different texture and porosity of each biomaterial. The aim of this study is to assess whether the implant of monofilament or multifilament meshes, in the inguinal hernioplasty, determine a different inflammatory response. Thirty-two male patients were included in the study and were randomly divided into two groups. In the first group (MO) inguinal hernioplasty was performed using monofilament polypropylene mesh, while in the second one (MU) multifilament prosthesis was used. Peripheral venous blood samples were collected 24 hours before surgery and then 6, 24, 48 and 168 hours post-operatively. Modifications in leukocyte count, C-reactive protein (CRP), alpha-1 antitrypsin (alpha1-AT), interleukin (IL)-1, IL-6, IL-1 ra and IL-10 serum levels were recorded at all sampling times. We present evidence that serum levels of CRP, (alpha1-AT), leukocytes and cytokines were significantly increased post-operatively in both groups, returning to basal values 168 hours afterwards. In particular, the production of all pro-inflammatory mediators was higher in the MU group, whereas the anti-inflammatory cytokine (IL-10, IL-1ra) production was higher in MO patients. Our results indicate that polypropylene multifilament mesh allows a higher intense acute inflammatory response as compared to monofilament mesh implantation.
authors.affiliation: Department of Surgical and Oncologic Science, Division of General Surgery, University of Palermo, Palermo, Italy. divitagaetano@libero.it
authors.forename: G
authors.initials: G
authors.lastname: Di Vita
authors.forename: R
authors.initials: R
authors.lastname: Patti
authors.forename: M
authors.initials: M
authors.lastname: Sparacello
authors.forename: C R
authors.initials: CR
authors.lastname: Balistreri
authors.forename: G
authors.initials: G
authors.lastname: Candore
authors.forename: C
authors.initials: C
authors.lastname: Caruso
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000097:blood; D005549:Foreign-Body Reaction / Q000209:etiology; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy; D011126:Polypropylenes / Q000009:adverse effects*; D013526:Surgical Mesh / Q000009:adverse effects*; D000515:alpha 1-Antitrypsin / Q000097:blood
chemical_list: D016207:Cytokines; D011126:Polypropylenes; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein