Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives.
Type II diabetes mellitus is currently globally one of the fastest growing non-communicable diseases, especially in developing countries. This investigation reports on a meta-analysis undertaken of the C-11377G locus within the adiponectin gene in a black South African, a Cuban Hispanic and a German Caucasian cohort. Genotyping was performed via a real-time PCR strategy. Both fixed- and random-effects models were tested to describe the diabetes risk at both the cohort and population levels. The 2,2 genotype may only be associated with increased diabetes risk in the Cuban Hispanic cohort. Population-specific effects may have masked these associations upon meta-analytical analysis, as no significant odds ratio could be determined. Thus, to examine diabetes risk, a more global approach including the design of population-specific experimental strategies should be used, which will be crucial in developing health education and policies in a global health programme.
Schwarz
P E H
PE
Division of Endocrinology, Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany. peter.schwarz@uniklinikum-dresden.de
Towers
G W
GW
van der Merwe
A
A
Perez-Perez
L
L
Rheeder
P
P
Schulze
J
J
Bornstein
S R
SR
Licinio
J
J
Wong
M-L
ML
Schutte
A E
AE
Olckers
A
A
D052242:Adiponectin / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000353:Africa, Southern / Q000453:epidemiology; D044383:Black People / Q000235:genetics; D015331:Cohort Studies; D003462:Cuba / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005828:Genetics, Population; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012306:Risk; D044465:White People / Q000235:genetics
C499918:ADIPOQ protein, human; D052242:Adiponectin