Stroke repair with cell transplantation: neuronal cells, neuroprogenitor cells, and stem cells.
Stroke is a common cause of death and disability. The role of cellular transplantation to promote functional recovery has been explored. Preclinical studies first established the potential for cultured neuronal cells derived from a teratocarcinoma cell line to be tested for safety and efficacy in the treatment of human stroke. In animal models of stroke that caused reproducible learning and motor deficits, injection of neuronal cells resulted in a return of learning behavior retention time and motor function. In this report the authors review several current concepts for cellular repair, discuss important patient selection and surgical technique issues, and discuss plans for future experiments.
Kondziolka
Douglas
D
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania, USA. kondziolkads@upmc.edu
Wechsler
Lawrence
L
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*; D020521:Stroke / Q000628:therapy*