title: Lithium enolates of simple ketones: structure determination using the method of continuous variation.
abstract: The method of continuous variation in conjunction with 6Li NMR spectroscopy was used to characterize lithium enolates derived from 1-indanone, cyclohexanone, and cyclopentanone in solution. The strategy relies on forming ensembles of homo- and heteroaggregated enolates. The enolates form exclusively chelated dimers in N,N,N',N'-tetramethylethylenediamine and cubic tetramers in tetrahydrofuran and 1,2-dimethoxyethane.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA.
authors.forename: Lara R
authors.initials: LR
authors.lastname: Liou
authors.forename: Anne J
authors.initials: AJ
authors.lastname: McNeil
authors.forename: Antonio
authors.initials: A
authors.lastname: Ramirez
authors.forename: Gilman E S
authors.initials: GE
authors.lastname: Toombes
authors.forename: Jocelyn M
authors.initials: JM
authors.lastname: Gruver
authors.forename: David B
authors.initials: DB
authors.lastname: Collum
mesh_terms: D003512:Cyclohexanones / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry; D007189:Indans / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D018020:Lithium Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D003512:Cyclohexanones; D003517:Cyclopentanes; D007189:Indans; D007659:Ketones; D018020:Lithium Compounds; D009942:Organometallic Compounds; C007201:cyclopentanone; C036468:cyclohexanone; C013352:indacrinone