title: [Pharmacokinetic study on baicalin of Qingkailing injection in rats].
abstract: OBJECTIVE
  Studying the metabolic pharmacokinetic of baicalin of Qingkailing injection in rat, to search for effector substance of Qingkailing injection in vivo.
  
  
  METHODS
  Qingkailing sterile injection powder was given by caudal vein, then blood, liver and lung were collected in various time, the concentration of baicalin from samples were determined by HPLC-MS. Pharmacokinetic evaluation was carried out using the 3P87.
  
  
  RESULTS
  After Qingkailing injection, Baicalin was consistent with two-compartment model in rat. 45 min, the concentration of baicalin in hepatic tissue reached maximum, followeded by decrease sharply, 120 min began to rise slowly, present double hump phenomenon. In lung, baicalin concentration was far more than in liver, was eliminated more slowly, but they have the same t(max).
  
  
  CONCLUSIONS
  After Qingkailing injection, baicalin distributed quickly to liver and lung, baicalin is one of effector substance of qingkailing injection in vivo. Baicalin might have hepatoenteral circulation.
authors.affiliation: Clinical Pharmacy Laboratory, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Xiao
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Huan-De
authors.initials: HD
authors.lastname: Li
authors.forename: Xu-Yuan
authors.initials: XY
authors.lastname: Zhao
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D008419:Materia Medica / Q000737:chemistry; D008657:Metabolic Clearance Rate; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D031364:Scutellaria baicalensis / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008419:Materia Medica; D011208:Powders; C504928:Qingkailing; C038044:baicalin