Anti-malarial activity of Eclipta alba against Plasmodium berghei infection in mice.
The anti-malarial activity of Eclipta alba leaves extract was evaluated against Plasmodium'berghei ANKA strain in mice. A standard inoculum of 1 x 10(6) infected erythrocytes was used. The methanolic leaf extract (250-750 mg/kg) produced a dose-dependant chemosupression or schizontocidal effect during early and established infection and high mean survival time (m.s.t.) values particularly in the group administered 750 mg/kg/day of extract. The plant extract also exhibited repository activity. The results of the preliminary studies carried out with E. alba are encouraging, which can be exploited in malaria therapy.
Bapna
Saroj
S
Haffkine Institute for Training Research and Testing, Parel, Mumbai.
Adsule
Shashank
S
Shirshat Mahendra
S
S
Jadhav
Suryaji
S
Patil
L S
LS
Deshmukh
R A
RA
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004195:Disease Models, Animal; D036601:Eclipta / Q000737:chemistry*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010962:Plasmodium berghei / Q000187:drug effects*; D016896:Treatment Outcome
D000962:Antimalarials; D010936:Plant Extracts