[The effectiveness of ascorbic acid and emoxipin in treatment of infiltrative pulmonary tuberculosis].
The aim of this prospective placebo-controlled randomized study was to assess the effectiveness of ascorbic acid or emoxipin in the regimen of the therapy of infiltrative pulmonary tuberculosis. Emoxipin vs. ascorbic acid favored the eradication of tuberculosis mycobacteria. Both preparations decreased the blood level of the contra-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), shortened time to the closure of degeneration cavities in tubercular infiltrations, decreased the risk of the development of destructive forms, and lowered the need for surgical interventions for infiltrative pulmonary tuberculosis.
Volchegorskiĭ
I A
IA
Novoselov
P N
PN
Astakhova
T V
TV
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007262:Infusions, Intravenous; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D010847:Picolines; D014409:Tumor Necrosis Factor-alpha; D014815:Vitamins; D001205:Ascorbic Acid; C009820:6-methyl-2-ethyl-3-hydroxypyridine