title: Factor V Leiden: is it the chief contributor to activated protein C resistance in Asian-Indian patients with deep vein thrombosis?
abstract: BACKGROUND
  Deep vein thrombosis is a condition, which has several acquired as well as genetic causes. One of the most common reasons for deep vein thrombosis is activated protein C resistance caused by Factor V Leiden.
  
  
  METHODS
  We examined the risk posed by Factor V Leiden, Hong Kong/Cambridge and HR2 Haplotype mutations in 155 deep vein thrombosis patients and 120 healthy controls in the background of activated protein C resistance.
  
  
  RESULTS
  Thirty-one of our patients showed activated protein C resistance of which only 16 carried Factor V Leiden mutation which was a far lower number than what is usually seen in Caucasian population. Factor V Leiden mutation was significantly associated with the risk of deep vein thrombosis (Yates corrected p-value=0.002; 95%CI; odds ratio: 13.7). Factor V Hong Kong/Cambridge and HR2 Haplotype were not found to be associated with the risk of deep vein thrombosis. There is a possibility that Factor V HR2 Haplotype might also be associated with activated protein C resistance even in the absence of Factor V Leiden.
  
  
  CONCLUSIONS
  Factor V Leiden mutation was seen to contribute far less towards activated protein C resistance in Asian-Indian deep vein thrombosis patients than what has been commonly observed in Caucasians.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Biswas
authors.forename: Jyoti
authors.initials: J
authors.lastname: Bajaj
authors.forename: Ravi
authors.initials: R
authors.lastname: Ranjan
authors.forename: Arvind
authors.initials: A
authors.lastname: Meena
authors.forename: Mohd Suhail
authors.initials: MS
authors.lastname: Akhter
authors.forename: Birendra Kumar
authors.initials: BK
authors.lastname: Yadav
authors.forename: Vinita
authors.initials: V
authors.lastname: Sharma
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D020016:Activated Protein C Resistance / Q000097:blood*; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006801:Humans; D007194:India; D008875:Middle Aged; D009154:Mutation; D020246:Venous Thrombosis / Q000097:blood* / Q000235:genetics*
chemical_list: C403771:factor V Hong Kong; C095381:factor V Leiden; D005165:Factor V