title: Increase in serum bilirubin levels in obstructive jaundice secondary to pancreatic and periampullary malignancy--implications for timing of resectional surgery and use of biliary drainage.
abstract: BACKGROUND
  Routine preoperative biliary drainage in cases of jaundice secondary to pancreatobiliary malignancy is associated with a significant risk of complications, failure and stent occlusion. It may be possible to avoid biliary drainage in those patients who are not deeply jaundiced.
  
  
  OBJECTIVE
  To measure presenting serum bilirubin and its rate of increase in patients with malignant obstructive jaundice. To predict the urgency with which surgery should be performed to avoid preoperative biliary drainage.
  
  
  METHODS
  Prospective data collection for all pancreatic and periampullary malignancies over a period of 18 months was carried out. Serum bilirubin levels before successful drainage were recorded. Rates of increase in bilirubin and the number of days for bilirubin to reach different thresholds were calculated.
  
  
  RESULTS
  Of 111 patients, 66 (59%) had resectable disease on imaging investigations. Median serum bilirubin on presentation was 160 micromol/l. Median increase was 13.1 micromol/l/day or approximately 100 micromol/l/week. The predicted number of days for bilirubin levels to reach a variety of thresholds varied significantly. For a patient presenting with a serum bilirubin of 160 micromol/l, the mean number of days for it to rise to 200 micromol/l, 300 micromol/l, 400 micromol/l and 500 micromol/l was 3, 13, 22 and 31 days, respectively.
  
  
  CONCLUSIONS
  There is a variable window of opportunity in jaundiced patients with pancreatic and periampullary malignancy during which surgery may be performed to avoid biliary drainage procedures, depending on the threshold for operating on the jaundiced patient.
authors.affiliation: Hepato-Pancreato-Biliary Unit, Freeman Hospital, Newcastle-upon-Tyne, UK.
authors.forename: S D
authors.initials: SD
authors.lastname: Mansfield
authors.forename: G
authors.initials: G
authors.lastname: Sen
authors.forename: K
authors.initials: K
authors.lastname: Oppong
authors.forename: B C
authors.initials: BC
authors.lastname: Jacques
authors.forename: C B
authors.initials: CB
authors.lastname: O'Suilleabhain
authors.forename: D M
authors.initials: DM
authors.lastname: Manas
authors.forename: R M
authors.initials: RM
authors.lastname: Charnley