title: Meclonazepam analogues as potential new antihelmintic agents.
abstract: New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni.
authors.affiliation: Department of Chemistry, University of Cape Town, Private Bag, Rondebosh-7701, South Africa.
authors.forename: Aman
authors.initials: A
authors.lastname: Mahajan
authors.forename: Vipan
authors.initials: V
authors.lastname: Kumar
authors.forename: Nuha R N
authors.initials: NR
authors.lastname: Mansour
authors.forename: Quentin
authors.initials: Q
authors.lastname: Bickle
authors.forename: Kelly
authors.initials: K
authors.lastname: Chibale
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000138:chemical synthesis / Q000494:pharmacology*; D008956:Models, Chemical; D012550:Schistosoma mansoni / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D002998:Clonazepam / Q000031:analogs & derivatives
chemical_list: D000871:Anthelmintics; D001570:Benzodiazepinones; C020602:meclonazepam; D002998:Clonazepam