title: Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization.
abstract: BACKGROUND
  Resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD), where patients with a history of coronary revascularization may pose special challenges. Several methods exist to enhance sensitivity and specificity of resting ECG for diagnosis of CAD, but such methods are not better than a specialist's judgement. We compared a new computer-enhanced, resting ECG analysis device, 3DMP, to coronary angiography to evaluate the device's accuracy in detecting hemodynamically relevant CAD.
  
  
  METHODS
  A convenience sample of 172 patients with a history of coronary revascularization scheduled for coronary angiography was evaluated with 3DMP before coronary angiography. 3DMP's sensitivity and specificity in detecting hemodynamically relevant coronary stenosis as diagnosed with coronary angiography were calculated as well as odds ratios for the 3DMP severity score and coronary artery disease risk factors.
  
  
  RESULTS
  The 3DMP system accurately identified 50 of 55 patients as having hemodynamically relevant stenosis (sensitivity 90.9%, specificity 88.0%). Positive and negative predictive values for the identification of coronary stenosis as diagnosed in coronary angiograms were 62.7% and 97.8% respectively. Risk and demographic factors in a logistic regression model had a markedly lower predictive power for the presence of coronary stenosis in these patients than did 3DMP severity score (odds ratio 2.04 [0.74-5.62] vs. 73.57 [25.10-215.68]). A logistic regression combining severity score with risk and demographic factors did not add significantly to the prediction quality (odds ratio 80.00 [27.03-236.79]).
  
  
  CONCLUSIONS
  3DMP's computer-based, mathematically derived analysis of resting two-lead ECG data provides detection of hemodynamically relevant CAD in patients with a history of coronary revascularization with high sensitivity and specificity that appears to be at least as good as those reported for other resting and/or stress ECG methods currently used in clinical practice.
authors.affiliation: Department of Cardiology, Angiology, HELIOS Heart Center Siegburg, Siegburg, Germany.
authors.forename: Eberhard
authors.initials: E
authors.lastname: Grube
authors.forename: Andreas
authors.initials: A
authors.lastname: Bootsveld
authors.forename: Lutz
authors.initials: L
authors.lastname: Buellesfeld
authors.forename: Seyrani
authors.initials: S
authors.lastname: Yuecel
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Shen
authors.forename: Michael
authors.initials: M
authors.lastname: Imhoff
mesh_terms: D000368:Aged; D019540:Area Under Curve; D017023:Coronary Angiography / Q000379:methods / Q000592:standards*; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000473:pathology; D003936:Diagnosis, Computer-Assisted; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted