title: Adrenalectomy for clinically isolated metastasis from colorectal carcinoma: report of eight cases.
abstract: OBJECTIVE
  Metastasis to the adrenal glands is a relatively frequent finding at autopsy. Adrenal metastasis of colorectal carcinoma is rare (14 percent). Isolated adrenal metastasis is even rarer, and presents a therapeutic dilemma.
  
  
  METHODS
  Between 1997 and 2006, eight patients (5 men; mean age, 62 years) underwent adrenalectomy for metastasis of colorectal carcinoma. The tumors were Stage D in four cases, Stage B in two cases, and Stage C in the remaining two. Adjuvant chemotherapy was instituted.
  
  
  RESULTS
  All patients were asymptomatic, and adrenal metastasis was suspected from an elevated serum level of carcinoembryogenic antigen or discovered by computed tomography. Adrenal metastases were metachronous in seven patients, with median disease-free interval of 3.75 years. At the time of follow-up, one patient remained alive and free of disease 12 months after adrenalectomy, one patient was lost to follow-up after 22 months, and 6 patients have died from malignancy. The mean survival for the patients who died was 32 months.
  
  
  CONCLUSIONS
  The rarity of isolated adrenal metastasis of colorectal carcinoma makes a randomized, prospective trial comparing surgery vs. nonsurgical management highly unlikely. Our results provide further support for surgical resection of solitary adrenal metastasis, which may translate into survival benefit.
authors.affiliation: Department of Pathology, Hôpital St-Antoine, Paris, France. najat.mourra@sat.ap-hop-paris.fr
authors.forename: Najat
authors.initials: N
authors.lastname: Mourra
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.forename: Pierre
authors.initials: P
authors.lastname: Duvillard
authors.forename: Catherine
authors.initials: C
authors.lastname: Guettier
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Flejou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Tiret
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary* / Q000601:surgery*; D000315:Adrenalectomy; D000368:Aged; D002277:Carcinoma / Q000556:secondary* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome