[Age-related changes of albumin and actin of human myocardium].
In the human myocardium tissue, proteomic technologies revealed the products of 2 genes (alpha-actin and albumin), existing as fragments; their appearance and increased contents correlated with age. The age-related variants differ from the mature forms by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-dependent proteins were found in 50% of cases (in the age group 31-40 years), while in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the cardiac muscle and also of the adaptation-dysadaptations mechanisms in the CIHD.
Kovaleva
M A
MA
Kovalev
L I
LI
Serebriakova
M V
MV
Moshkovskiĭ
S A
SA
Shishkin
S S
SS
D000199:Actins / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000418:Albumins / Q000378:metabolism*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D040901:Proteomics
D000199:Actins; D000418:Albumins