title: Cocaine-paired cues activate aversive representations in accumbens neurons.
abstract: Aversive states are proposed to drive addiction. Here, Wheeler and colleagues show that drug-associated cues come to activate neural representations of aversive information in nucleus accumbens and that this activation predicts subsequent drug use. These remarkable data identify a potential neural substrate through which aversive affective representations may motivate drug use.
authors.affiliation: Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Calu
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Schoenbaum
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000503:physiopathology; D003042:Cocaine / Q000008:administration & dosage; D003463:Cues; D006801:Humans; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*
chemical_list: D003042:Cocaine