title: Dietary oleic acid and adipocyte lipolytic activity in culture.
abstract: Although various studies have noted fatty-acid-mediated regulation of adipocyte lipolysis, determining the isolated effect of a single fatty acid is more difficult. We examined the influence of dietary oleic acid on adipose cell lipolytic activity and the tissue fat content independently of the variation in other dietary fatty acids. We fed 48 rats with six diets designed so that the oleic acid content was not correlated with the content of any other fatty acid and studied the lipolytic activity and fatty acid content of the tissues. There were no differences in the weight of the animals after the diet. The muscle fat content and the epinephrine-stimulated lipolytic activity varied significantly according to the dietary levels of oleic acid and the tissues, showing a dose-dependent behavior of the dietary oleic acid concentration. The results of this study show that diets rich in oleic acid have a beneficial effect on the regulation of lipid metabolism and body weight homeostasis.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain. eyring@gmail.com
authors.forename: Eva
authors.initials: E
authors.lastname: García-Escobar
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
authors.forename: Sara
authors.initials: S
authors.lastname: García-Serrano
authors.forename: Juan M
authors.initials: JM
authors.lastname: Gómez-Zumaquero
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Morcillo
authors.forename: Juan
authors.initials: J
authors.lastname: Haro
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo-Martínez
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D004041:Dietary Fats / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008066:Lipolysis; D008297:Male; D009132:Muscles / Q000378:metabolism; D019301:Oleic Acid / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids; D019301:Oleic Acid