title: Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds.
abstract: Changes in gene expression levels of c-myc and CD38 were examined during the differentiation of HL-60 cells to granulocytes due to three nicotinic acid-related compounds. CD38 expression was increased by isonicotinic acid and all-trans-retinoic acid (ATRA). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways. These results should provide useful information as to the mechanisms of cell differentiation.
authors.affiliation: Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan.
authors.forename: Chieri
authors.initials: C
authors.lastname: Ida
authors.forename: Shin
authors.initials: S
authors.lastname: Ogata
authors.forename: Katsuzumi
authors.initials: K
authors.lastname: Okumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Taguchi
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis / Q000235:genetics*; D002454:Cell Differentiation / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006098:Granulocytes / Q000166:cytology; D018922:HL-60 Cells; D006801:Humans; D022423:Myeloid Cells / Q000166:cytology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C489427:MYC protein, human; D009539:Nicotinic Acids; D016271:Proto-Oncogene Proteins c-myc; D051997:ADP-ribosyl Cyclase 1