Synthesis of UDP-glucose derivatives modified at the 3-OH as potential chain terminators of beta-glucan biosynthesis.
A series of UDP-D-glucose derivatives and precursors that have been modified at C-3 were synthesised from D-glucose as potential chain terminators of beta-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.
Danac
Ramona
R
Chemistry Research Laboratory, Department of Plant Sciences, Oxford University, Mansfield Road, Oxford OX1 3TA, UK.
Ball
Lucy
L
Gurr
Sarah J
SJ
Fairbanks
Antony J
AJ
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects* / Q000502:physiology; D014532:Uridine Diphosphate Glucose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047071:beta-Glucans / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000935:Antifungal Agents; D047071:beta-Glucans; C033363:beta-1,3-glucan; D014532:Uridine Diphosphate Glucose