Synthesis of bis-diosgenin pyrazine dimers: new cephalostatin analogs.
A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of alpha-amino ketones, the most efficient method for pyrazine ring construction.
Shawakfeh
Khaled Q
KQ
Department of Applied Chemical Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. shawakfa@just.edu
Al-Said
Naim H
NH
Al-Zoubi
Raed M
RM
D019281:Dimerization; D004144:Diosgenin / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D011719:Pyrazines; D004144:Diosgenin