Diversity of polyketide synthases found in the Aspergillus and Streptomyces genomes.
Natural products produced by biological organisms have played an important role in human health. The genomes of several Aspergillus species and several Streptomyces species have recently been sequenced. Interestingly the genomes revealed a large range of secondary metabolite genes, for many of which the products are currently unknown, suggesting that there is a wealth of secondary metabolites yet to be discovered. This brief review will discuss the current knowledge in polyketides produced by the various different classes of polyketide synthases (PKSs) present in the Aspergillus and Streptomyces genomes.
Sanchez
James F
JF
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089, USA.
Chiang
Yi-Ming
YM
Wang
Clay C C
CC
D001230:Aspergillus / Q000201:enzymology / Q000235:genetics*; D016680:Genome, Bacterial; D016681:Genome, Fungal; D048630:Polyketide Synthases / Q000235:genetics*; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics*
D048630:Polyketide Synthases