title: Chronic autoimmune thyroiditis (Hashimoto's thyroiditis) in patients with MALT lymphoma.
abstract: BACKGROUND
  Autoimmune diseases have been implicated in the genesis of MALT lymphoma of various localizations. The development of thyroidal MALT lymphoma has been described as an adverse event in patients suffering from long-standing chronic autoimmune thyroiditis (CAT, Hashimoto's thyroiditis). The percentage and possible association between CAT and extrathyroidal MALT lymphoma, however, have not been assessed so far.
  
  
  METHODS
  A retrospective analysis of 80 patients with MALT lymphoma diagnosed and treated at our institution identified a total of 13 patients (16%) with MALT lymphoma suffering from an underlying CAT. Patient characteristics including site of disease, stage, genetic changes and clinical course were assessed and evaluated.
  
  
  RESULTS
  In total, 10 patients were female and 3 male, with the median age being 57 years (range: 31-80). Four patients suffered from thyroidal lymphoma and nine patients had extrathyroidal lymphoma (four gastric, two orbital, one small intestinal and two salivary gland lymphomas). Three patients had a long-standing history of CAT at diagnosis of MALT lymphoma, while CAT was discovered during staging and clinical work-up of MALT lymphoma in the remaining 10 patients. All 13 patients had localized disease, i.e. stage I or II. Only one of the four patients with gastric MALT lymphoma responded to antibiotic treatment against Helicobacter pylori infection. Genetic aberrations were detected in four patients, two of whom had a t(11;18)(q21;q21) translocation, one patient had trisomies 3 and 18 and one had trisomy 18.
  
  
  CONCLUSIONS
  Our findings suggest that CAT is found in patients with not only thyroidal but also nonthyroidal MALT lymphoma. While the nature of our data does not allow for delineation of a direct association between CAT and development of extrathyroidal MALT lymphoma, further prospective studies on this issue are warranted.
authors.affiliation: Division of Oncology, Department of Internal Medicine I.
authors.forename: M
authors.initials: M
authors.lastname: Troch
authors.affiliation: Division of Oncology, Department of Internal Medicine I.
authors.forename: S
authors.initials: S
authors.lastname: Woehrer
authors.affiliation: Department of Pathology.
authors.forename: B
authors.initials: B
authors.lastname: Streubel
authors.affiliation: Department of Internal Medicine III.
authors.forename: M
authors.initials: M
authors.lastname: Weissel
authors.affiliation: Department of Nuclear Medicine, University of Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Hoffmann
authors.affiliation: Department of Pathology.
authors.forename: L
authors.initials: L
authors.lastname: Müllauer
authors.affiliation: Department of Pathology.
authors.forename: A
authors.initials: A
authors.lastname: Chott
authors.affiliation: Division of Oncology, Department of Internal Medicine I. Electronic address: markus.raderer@meduniwien.ac.at.
authors.forename: M
authors.initials: M
authors.lastname: Raderer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D003131:Combined Modality Therapy; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D009367:Neoplasm Staging; D012074:Remission Induction; D012189:Retrospective Studies; D000069283:Rituximab; D016019:Survival Analysis; D013997:Time Factors; D014178:Translocation, Genetic; D016896:Treatment Outcome; D014314:Trisomy; D014463:Ultrasonography
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab; D004318:Doxycycline