[Gastric calcifying fibrous pseudotumor, a rare mesenchymal tumor of the stomach].
We report a case of calcifying fibrous pseudotumor fortuitously discovered on abdominal CT-scan in a 50 year-old woman presenting with metrorragia. CT-scan showed a 2 cm hypodense nodular tumor of the gastric wall with granular calcifications. Upper endoscopy showed a nodular tumor along the lesser curvature of the gastric body, covered by normal gastric mucosa and biopsies were negative. A diagnosis of gastric stromal tumor was suspected and a partial gastrectomy was performed. On gross examination surgical specimen showed a firm, whitish nodular tumor measuring 2 cm in diameter. On microscopic examination the tumor was composed of whorls of dense hyalinized collagen bundles with a few fibroblasts. There were psammomatous calcifications and nodular aggregates of mononuclear inflammatory cells. Immunohistochemically, spindle cells stained for vimentin. They did not stain for smooth muscle actin, desmin, CD34, CD117, S100 protein, Ki-67 and ALK-1. Surgical resection of the tumor was complete. Patient has no evidence of disease with a follow-up of 12 months. Only seven cases of gastric calcifiying fibrous pseudotumors have been reported in the literature. These benign tumors are usually incidentally discovered. They have characteristic imaging and microscopic features and appear as a distinct clinicopathologic entity different from stromal tumors.
Chatelain
D
D
Service d'anatomie pathologique, CHU d'Amiens, place Victor-Pauchet, 80054 Amiens cedex 01, France. Chatelain.denis@chu-amiens.fr
Lauzanne
P
P
Yzet
T
T
Guernou
M
M
Delcenserie
R
R
Regimbeau
J-M
JM
Sevestre
H
H
D002114:Calcinosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*