title: Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil.
abstract: An outbreak of cephalosporin-resistant Klebsiella pneumoniae occurred in a neonatal intensive care unit in São Paulo, Brazil. Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. bla(CTX-M-2/59) genes were located on closely related plasmids that were transferable.
authors.affiliation: Instituto Adolfo Lutz, São Paulo, Brazil.
authors.forename: Doroti
authors.initials: D
authors.lastname: de Oliveira Garcia
authors.forename: Yohei
authors.initials: Y
authors.lastname: Doi
authors.forename: Dora
authors.initials: D
authors.lastname: Szabo
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Adams-Haduch
authors.forename: Tânia M I
authors.initials: TM
authors.lastname: Vaz
authors.forename: Daniela
authors.initials: D
authors.lastname: Leite
authors.forename: Maria Clara
authors.initials: MC
authors.lastname: Padoveze
authors.forename: Maristela P
authors.initials: MP
authors.lastname: Freire
authors.forename: Fernanda P
authors.initials: FP
authors.lastname: Silveira
authors.forename: David L
authors.initials: DL
authors.lastname: Paterson
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001938:Brazil / Q000453:epidemiology; D002511:Cephalosporins / Q000494:pharmacology; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002511:Cephalosporins; C071167:beta-lactamase CTX-2; D001618:beta-Lactamases