title: Antifungal activity of Agapanthus africanus extractives.
abstract: The ethanolic extract of the rhizomes of Agapanthus africanus showed antifungal activity. In bioassay guided fractionation, n-butanol fraction exhibited significant activity against human pathogens. A saponin, (25R)-spirost-7-en-2alpha,3beta,5alpha-triol-3-O-[alpha-L-rhamnopyranosyl(1-->2)-[beta-D-galactopyranosyl (1-->3)] beta-D-glucopyranoside (1), responsible for the antifungal activity and having MIC value of 15.6 microg/ml against Trychophyton mentagrophytes and Sporothrix schenekii, was isolated and identified as active constituent of the plant.
authors.affiliation: Process and Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India. dnsinghsaket@yahoo.com
authors.forename: D N
authors.initials: DN
authors.lastname: Singh
authors.forename: N
authors.initials: N
authors.lastname: Verma
authors.forename: S
authors.initials: S
authors.lastname: Raghuwanshi
authors.forename: P K
authors.initials: PK
authors.lastname: Shukla
authors.forename: D K
authors.initials: DK
authors.lastname: Kulshreshtha
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D006168:Guinea Pigs; D019668:Liliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology; D014005:Tinea / Q000188:drug therapy; D014249:Trichophyton / Q000187:drug effects
chemical_list: C532553:(25R)-spirost-7-en-2alpha,3beta,5alpha-triol-3-O-(alpha-L-rhamnopyranosyl(1-2)beta-D-galactopyranosyl (1-3)) beta-D-glucopyranoside; D000935:Antifungal Agents; D010936:Plant Extracts; D012503:Saponins