title: Neuropeptide Y receptor-specifically modulates human neutrophil function.
abstract: Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species.
authors.affiliation: Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Bedoui@wehi.edu.au
authors.forename: Sammy
authors.initials: S
authors.lastname: Bedoui
authors.forename: Andreas
authors.initials: A
authors.lastname: Kromer
authors.forename: Thomas
authors.initials: T
authors.lastname: Gebhardt
authors.forename: Roland
authors.initials: R
authors.lastname: Jacobs
authors.forename: Kerstin
authors.initials: K
authors.lastname: Raber
authors.forename: Mirja
authors.initials: M
authors.lastname: Dimitrijevic
authors.forename: Jörn
authors.initials: J
authors.lastname: Heine
authors.forename: Stephan
authors.initials: S
authors.lastname: von Hörsten
mesh_terms: D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D011869:Radioligand Assay; D017382:Reactive Oxygen Species / Q000378:metabolism; D017476:Receptors, Neuropeptide Y / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D017382:Reactive Oxygen Species; D017476:Receptors, Neuropeptide Y; D009240:N-Formylmethionine Leucyl-Phenylalanine