Proximicins A, B, and C-antitumor furan analogues of netropsin from the marine actinomycete Verrucosispora induce upregulation of p53 and the cyclin kinase inhibitor p21.
Schneider
Kathrin
K
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin, Germany.
Keller
Simone
S
Wolter
Falko E
FE
Röglin
Lars
L
Beil
Winfried
W
Seitz
Oliver
O
Nicholson
Graeme
G
Bruntner
Christina
C
Riedlinger
Julia
J
Fiedler
Hans-Peter
HP
Süssmuth
Roderich D
RD
D039903:Actinobacteria / Q000737:chemistry; D000970:Antineoplastic Agents / Q000494:pharmacology*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005663:Furans; D015394:Molecular Structure; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D015854:Up-Regulation / Q000187:drug effects*
D000970:Antineoplastic Agents; D050759:Cyclin-Dependent Kinase Inhibitor p21; D005663:Furans; D016159:Tumor Suppressor Protein p53; C529559:proximicin A; C529560:proximicin B; C529561:proximicin C; D009429:Netropsin; C039281:furan