Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis.
Fundic gland polyps are now commonly recognized during endoscopy. These polyps are benign, often multiple and usually detected in the gastric body and fundus. In the past, these polyps were sometimes associated with familial adenomatous polyposis. In recent years, it has become evident that increasing numbers of these polyps are being detected during endoscopic studies, particularly in patients treated with proton pump inhibitors for prolonged periods. In some, dysplastic changes in these polyps have also been reported. Recent studies have suggested that there may be no increase in risk of colon cancer with long-term proton pump inhibitor therapy. While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted.
Freeman
Hugh-James
HJ
Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada. hugfree@shaw.ca
D011125:Adenomatous Polyposis Coli / Q000139:chemically induced / Q000175:diagnosis; D005748:Gastric Fundus; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D006801:Humans; D011127:Polyps / Q000139:chemically induced* / Q000175:diagnosis; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D013272:Stomach Diseases / Q000139:chemically induced* / Q000175:diagnosis
D054328:Proton Pump Inhibitors