Tenoxicam modulates antioxidant redox system and lipid peroxidation in rat brain.
We investigated effects of two doses of Tenoxicam, a type 2 cyclooxygenase inhibitor, administration on lipid peroxidation and antioxidant redox system in cortex of the brain in rats. Twenty-two male Wistar rats were randomly divided into three groups. First group was used as control. 10 and 20 mg/kg body weight Tenoxicam were intramuscularly administrated to rats constituting the second and third groups for 10 days, respectively. Both dose of Tenoxicam administration resulted in significant increase in the glutathione peroxidase activity, reduced glutathione and vitamins C and E of cortex of the brain. The lipid peroxidation levels in the cortex of the brain were significantly decreased by the administration. Vitamin A and beta-carotene concentration was not affected by the administration. There was no statistical difference in all values between 10 and 20 mg Tenoxicam administrated groups. In conclusion, treatment of brain with 10 and 20 mg Tenoxicam has protective effects on the oxidative stress by inhibiting free radical and supporting antioxidant redox system.
Naziroğlu
Mustafa
M
Department of Biophysics, Medical (TIP) Faculty, Süleyman Demirel University, Cunur, Isparta, 32260, Turkey. mnaziroglu@med.sdu.edu.tr
Uğuz
Abdulhadi Cihangir
AC
Gokçimen
Alpaslan
A
Bülbül
Metin
M
Karatopuk
Dilek Ulusoy
DU
Türker
Yasin
Y
Cerçi
Celal
C
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism; D019207:beta Carotene / Q000378:metabolism
D000975:Antioxidants; D016861:Cyclooxygenase Inhibitors; D019207:beta Carotene; D014801:Vitamin A; D010894:Piroxicam; D014810:Vitamin E; D005979:Glutathione Peroxidase; D005978:Glutathione; C032801:tenoxicam