title: A cost comparison of two strategies for treating stage IB2 cervical cancer.
abstract: Patients with stage IB2 cervical cancer at our institution are treated primarily with definitive chemoradiation, or chemoradiation followed by adjuvant hysterectomy. We sought to compare the cost differences associated with these two strategies. We identified all patients with stage IB2 cervical cancer who received their entire treatment regimen at our institution between 1995 and 2004. All patients received a combination of chemotherapy, external beam radiation, and one brachytherapy procedure, followed by either a second brachytherapy procedure or a simple hysterectomy. We retrieved cost data associated with hospitalization for the completion of respective treatment, including pharmacy, laboratory and pathology, radiation, and operating room services, as well as the costs of supplies and room and board. We identified 46 patients with stage IB2 cervical cancer, 23 who received a second brachytherapy procedure and 23 who underwent simple hysterectomy. Patients displayed similar demographics and similar disease characteristics including initial tumor diameter and histology. The cost of care for adjuvant hysterectomy group was greater ($8,316.70 vs 5,508.70, P < 0.0001). Specific differences included higher operating room costs ($1520 vs 414, P < 0.0001), pharmacy costs ($675 vs 342, P < 0.0001), and laboratory/pathology costs ($597 vs 89, P < 0.0001). We conclude that definitive chemoradiation appears to be associated with lower costs for management of stage IB2 cervical cancer when compared to simple adjuvant hysterectomy.
authors.affiliation: Division of Gynecologic Oncology, University of Virginia Health System, Charlottesville, Virginia 22908-0712, USA. jal5f@virginia.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Lachance
authors.forename: C J
authors.initials: CJ
authors.lastname: Darus
authors.forename: G J
authors.initials: GJ
authors.lastname: Stukenborg
authors.forename: B F
authors.initials: BF
authors.lastname: Schneider
authors.forename: L W
authors.initials: LW
authors.lastname: Rice
authors.forename: A A
authors.initials: AA
authors.lastname: Jazaeri
mesh_terms: D000970:Antineoplastic Agents / Q000191:economics* / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000191:economics; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000191:economics*; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000191:economics*; D002583:Uterine Cervical Neoplasms / Q000191:economics* / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents