CDKN2A deletions in acute lymphoblastic leukemia of adolescents and young adults: an array CGH study.
Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10-25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deletions (<200 kb) were found in 8/25 (32%) and the smallest deletion was <30 kb. The only gene affected in all deletions was CDKN2A. We were unable to demonstrate prognostic value of the deletion, however patients with deletion belonged more often (P=0.06) to unfavorable biological category. Our results indicate that CDKN2A deletions <200 kb may not be detected by conventional methods.
Usvasalo
Anu
A
Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. anu.usvasalo@helsinki.fi
Savola
Suvi
S
Räty
Riikka
R
Vettenranta
Kim
K
Harila-Saari
Arja
A
Koistinen
Pirjo
P
Savolainen
Eeva-Riitta
ER
Elonen
Erkki
E
Saarinen-Pihkala
Ulla M
UM
Knuutila
Sakari
S
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D019942:Genes, p16; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D017384:Sequence Deletion