Triterpenoidal saponins from Hydrocotyle sibthorpioides.
Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques ((13)C, (1)H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.
Huang
Hui-Chi
HC
National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, ROC.
Liaw
Chia-Ching
CC
Zhang
Li-Jie
LJ
Ho
Hsi-Uo
HU
Kuo
Li-Ming Yang
LM
Shen
Ya-Ching
YC
Kuo
Yao-Haur
YH
D004365:Drugs, Chinese Herbal / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; D009828:Oleanolic Acid