[Experimental studies on treatment of depression with YJ-XCC1Z3 in mouse models].
OBJECTIVE
To evaluate the pre-clinical effect of YJ-XCC1Z3 on the treatment of depression with the mice mouse.


METHODS
YJ-XCC1Z3 was administered at the dose of 405 mg x kg(-1) and 135 mg x kg(-1) to observe the locomotor activity with the mouse locomotor activity recorder apparatus, to observe the effect of YJ-XCC1Z3 on the duration of immohility in the mouse forced swimming test and tail suspension test, to observe the effect of YJ-XCC1Z3 on the body temperature and the metabolism of monoamine neurotransmitters in mouse brain in the mouse model of reserpine induced hypothermia, and to observe the effect of YJ-XCC1 Z3 on the times of 5-HTP induced head-twitches in mice.


RESULTS
There were no significant changes in the locomotor activity, but a significant reduction in the immobility time was observed in the mice treated with YJ-XCC1Z3 405 mg x kg(-1) and imipramine in the forced swimming test and the tail suspension test. YJ-XCC1Z3 135 mg x kg(-1) and 405 mg x kg(-1) could improve the range of reserpine induced hypothermia in mice, and the latter could also enhance the times of 5-HTP induced head-twitches in mice. YJ-XCC1Z3 405 mg x kg(-1) and 135 mg x kg(-1) could increase the content of 5-HT and NE and decrease the ratio of 5-HIAA/5-HT in mouse brain, but the dose of 405 mg x kg(-1) could decrease the content of DA. The dose of 405 mg x kg(-1) could increase the content of 5-HIAA and had no obvious effect on the content of HVA and DOPAC.


CONCLUSIONS
YJ-XCC1Z3 shows potent antidepressant effect by improving the behaviour of the mouse in depression and not inducing hyperlocomotion in the mice. This effect results in the increase of the content of 5-HT and NE in the mouse brain. YJ-XCC1Z3 can decrease the metabolism of 5-HT to effect the content of 5-HT.
Wei
Xiao-Hui
XH
Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China. xhweixh@163.com
Chang
Hong-Sheng
HS
Zhai
Wei-Feng
WF
Wang
Zheng-Tao
ZT
D000818:Animals; D000928:Antidepressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D031174:Atractylodes / Q000737:chemistry; D001921:Brain / Q000378:metabolism; D029786:Cyperus / Q000737:chemistry; D003863:Depression / Q000378:metabolism / Q000503:physiopathology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D032062:Gardenia / Q000737:chemistry; D046353:Immobility Response, Tonic / Q000187:drug effects*; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012701:Serotonin / Q000378:metabolism
D000928:Antidepressive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C531537:Yueju-Wan; D012701:Serotonin; D009638:Norepinephrine