title: No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements.
abstract: OBJECTIVE
  Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings.
  
  
  METHODS
  Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type 1 patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated.
  
  
  RESULTS
  Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72.
  
  
  CONCLUSIONS
  Microdialysis CGM can be accurately performed in the proximity of CSII systems.
authors.affiliation: Academic Medical Center, Amsterdam, the Netherlands. j.hermanides@amc.uva.nl
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hermanides
authors.forename: Iris M
authors.initials: IM
authors.lastname: Wentholt
authors.forename: Augustinus A
authors.initials: AA
authors.lastname: Hart
authors.forename: Joost B
authors.initials: JB
authors.lastname: Hoekstra
authors.forename: J Hans
authors.initials: JH
authors.lastname: DeVries
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007258:Informed Consent; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D018579:Patient Selection; D012680:Sensitivity and Specificity
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin