title: Biologically active tetralones from New Caledonian Zygogynum spp.
abstract: Bioassay guided purification of the ethyl acetate extracts of the bark and leaves of five New Caledonian Zygogynum species (Winteraceae) led to the isolation and characterization of four phenyl-3-tetralones (3,4-dihydronaphthalen-1(2H)-one). Their structures were determined by various NMR techniques and chemical studies. The absolute configuration of the compounds was established by circular dichroism. The compounds showed binding affinity for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and significant inhibitory activity against KB cancer cell line.
authors.affiliation: Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Allouche
authors.forename: Barbara
authors.initials: B
authors.lastname: Morleo
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Olivier
authors.initials: O
authors.lastname: Nosjean
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009510:New Caledonia; D047495:PPAR gamma / Q000187:drug effects; D035261:Plant Components, Aerial; D044024:Tetralones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D032423:Winteraceae / Q000737:chemistry*
chemical_list: D047495:PPAR gamma; D044024:Tetralones; C531206:zygolone A