title: ACE gene polymorphism and cardiac structure in patients with insulin resistance.
abstract: OBJECTIVE
  Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II, thus may participate in the modulation of cardiac growth. The aim of our study is to analyze the ACE gene I/D polymorphisms in patients with insulin resistance (IR) and to evaluate its relationship to left ventricular mass and functions.
  
  
  METHODS
  Eighteen subjects (13 female and 5 male, mean age 39.8 +/- 14) with IR were enrolled in the present study. Twenty-three healthy people without IR were recruited as the control group. ACE amplification of DNA was performed by polymerase chain reaction methodology. Fasting glucose and insulin, postprandial glucose, homeostasis model assessment (HOMA-IR) and HOMA-beta, lipid profile, anthropometric measurements were assessed. Left ventricular structure and functions were measured by echocardiography.
  
  
  RESULTS
  Distribution of I/D polymorphism of the ACE gene in the study group was as follows: genotype II-0%, ID-38.9%, DD-61.1% of patients. Distribution of individual genotypes was similar in patients with and without IR. No significant difference was found between genotype groups in terms of anthropometric measurements and metabolic parameters and blood pressure. Echocardiography showed no significant changes in left ventricular structure and functions in patients with IR.
  
  
  CONCLUSIONS
  We considered that in patients with IR, there is no relationship between I/D polymorphism of the ACE gene and LVH.
authors.affiliation: Faculty of Medicine, Department of Endocrinology and Metabolism, Pamukkale University, Kinikli Campus, 20070 Denizli, Turkey. fulyaendo@yahoo.com.tr
authors.forename: Fulya
authors.initials: F
authors.lastname: Akin
authors.forename: Sebahat
authors.initials: S
authors.lastname: Turgut
authors.forename: Dursun
authors.initials: D
authors.lastname: Dursunoglu
authors.forename: Gunfer
authors.initials: G
authors.lastname: Turgut
authors.forename: Ugur
authors.initials: U
authors.lastname: Karasu
authors.forename: Sukru
authors.initials: S
authors.lastname: Gur
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D007703:Peptidyl-Dipeptidase A