title: Alkaline diets favor lean tissue mass in older adults.
abstract: BACKGROUND
  Maintaining muscle mass while aging is important to prevent falls and fractures. Metabolic acidosis promotes muscle wasting, and the net acid load from diets that are rich in net acid-producing protein and cereal grains relative to their content of net alkali-producing fruit and vegetables may therefore contribute to a reduction in lean tissue mass in older adults.
  
  
  OBJECTIVE
  We aimed to determine whether there was an association of 24-h urinary potassium and an index of fruit and vegetable content of the diet with the percentage lean body mass (%LBM) or change in %LBM in older subjects.
  
  
  METHODS
  Subjects were 384 men and women > or =65 y old who participated in a 3-y trial comparing calcium and vitamin D with placebo. Potassium was measured in 24-h urine collections at baseline. The %LBM, defined as total body nonfat, nonbone tissue weight/weight x 100, was measured by using dual-energy X-ray absorptiometry at baseline and at 3 y. Physical activity, height, and weight were assessed at baseline and at 3 y.
  
  
  RESULTS
  At baseline, the mean urinary potassium excretion was 67.0 +/- 21.1 mmol/d. Urinary potassium (mmol/d) was significantly positively associated with %LBM at baseline (beta = 0.033, P = 0.006; adjusted for sex, weight, and nitrogen excretion) but not with 3-y change in %LBM. Over the 3-y study, %LBM increased by 2.6 +/- 3.6%.
  
  
  CONCLUSIONS
  Higher intake of foods rich in potassium, such as fruit and vegetables, may favor the preservation of muscle mass in older men and women.
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: Bess
authors.initials: B
authors.lastname: Dawson-Hughes
authors.forename: Susan S
authors.initials: SS
authors.lastname: Harris
authors.forename: Lisa
authors.initials: L
authors.lastname: Ceglia
mesh_terms: D015502:Absorptiometry, Photon; D000136:Acid-Base Equilibrium; D000368:Aged; D000375:Aging / Q000502:physiology* / Q000652:urine; D001823:Body Composition / Q000502:physiology*; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D009133:Muscular Atrophy / Q000517:prevention & control; D009584:Nitrogen / Q000652:urine; D011188:Potassium / Q000652:urine*; D017419:Potassium, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D011795:Surveys and Questionnaires; D014675:Vegetables / Q000737:chemistry
chemical_list: D017419:Potassium, Dietary; D003404:Creatinine; D009584:Nitrogen; D011188:Potassium