Release behavior of salicylic acid in supramolecular hydrogels formed by l-phenylalanine derivatives as hydrogelator.
Supramolecular hydrogels were prepared from l-phenylalanine derivatives as novel hydrogelators. Salicylic acid (SA), acting as a model drug, was entrapped in the supramolecular hydrogels. The release behavior of SA molecules in the supramolecular hydrogels was investigated by using UV-vis spectroscopy. The influence of the concentration of the hydrogelator, pH values of the accepting media, the temperature, and the concentration of SA on the release behavior of SA was investigated under static conditions. The results indicated that the release rate of SA in the supramolecular hydrogels was slightly retarded with an increase of the hydrogelator concentration. Also, the release rates of SA increased with an increase of temperature and with the SA content. Furthermore, the release behavior of SA was found to be different at various pH values in buffers as accepting media. The study of the release kinetics indicated that the release behavior of SA was in accord with the Higuchi equation and the diffusion-controlled mechanism involved in the Fickian model.
Cao
Shuqin
S
Department of Chemistry, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, China.
Fu
Xinjian
X
Wang
Ningxia
N
Wang
Hong
H
Yang
Yajiang
Y
D002021:Buffers; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005079:Excipients; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D002021:Buffers; D005079:Excipients; D020100:Hydrogels; D010649:Phenylalanine; D020156:Salicylic Acid