Prorenin anno 2008.
For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.
Danser
A H Jan
AH
Division of Vascular Pharmacology and Metabolism, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, Rotterdam, The Netherlands. a.danser@erasmusmc.nl
Batenburg
Wendy W
WW
van Esch
Joep H M
JH
Krop
Manne
M
D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism; D012083:Renin / Q000378:metabolism*; D000093342:Prorenin Receptor; D000092502:Renin Inhibitors
D000809:Angiotensins; D011956:Receptors, Cell Surface; D012083:Renin; D000093342:Prorenin Receptor; D000092502:Renin Inhibitors