Application of immunohistochemistry to gynecologic pathology.
BACKGROUND
A large variety of tumors and lesions arise in the female genital tract. Although the majority of these can be correctly recognized on routine hematoxylin-eosin-stained slides, occasional cases present a diagnostic challenge. Immunohistochemical stains are extremely useful in resolving many of these problematic cases. As the knowledge in this area is constantly expanding, it is useful to have this updated information in a review form for easy access.


OBJECTIVE
To present our current knowledge of immunohistochemistry of the lesions of the female genital tract in a readily accessible form.


METHODS
The review is based on previously published articles on this topic.


CONCLUSIONS
Immunohistochemical stains help in reaching a conclusive diagnosis in a variety of problematic lesions seen in gynecologic pathology. As in any other system, immunohistochemical findings need to be interpreted in light of the clinical history and morphologic findings.
Mittal
Khush
K
Department of Pathology, NYU School of Medicine and Surgical and Ob-Gyn Pathology, Bellevue Hospital, Room 4 west 1, 462 First Ave, New York, NY 10016, USA. Mittak01@med.nyu.edu
Soslow
Robert
R
McCluggage
W G
WG
D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis; D005833:Genital Neoplasms, Female / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry
D014408:Biomarkers, Tumor