title: Purine-containing cucurbitane triterpenoids from Cucurbita pepo cv dayangua.
abstract: Phytochemical investigation of the fruits of Cucurbita pepo cv dayangua led to the isolation of cucurbitaglycosides A (1) and B (2). This is the first report of cucurbitane triterpenoids with a purine unit. Their structures were elucidated mainly based on interpretation of HRESIMS results, as well as 1D and 2D NMR spectra. Cucurbitaglycosides A and B showed cytotoxic activity against the human epithelial carcinoma cell line HeLa with IC50 of 17.2 and 28.4 microg/mL, respectively.
authors.affiliation: School of Veterinary Science, Jilin University, Jilin 130062, China.
authors.forename: Da-Cheng
authors.initials: DC
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Xiang
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Hui-Yuan
authors.initials: HY
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wu
authors.forename: Xu-Ming
authors.initials: XM
authors.lastname: Deng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D028464:Cucurbita / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011687:Purines / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D011687:Purines; D014315:Triterpenes; C514277:cucurbitane