title: [Concurrent chemoradiotherapy for squamous cell carcinoma of the anal canal-report of four cases].
abstract: We have treated four Japanese patients with squamous cell carcinoma of the anal canal using concurrent chemoradiotherapy. The chemotherapy consisted of one or two cycles of mitomycin C 10 mg/m(2)/day (intravenous bolus injection) on day 1, and 5-fluorouracil 700 or 1,000 mg/m(2)/day (continuous intravenous infusion) on days 2-5 during radiotherapy. The total radiation dose was 40-54 Gy to the primary lesion. Acute grade 4 hematological toxicity was observed in one patient. These four patients have been alive and free of disease (follow-ups of 55, 14, 7 and 5 months, respectively), with excellent function of the anal sphincter after treatment. These results suggest that concurrent chemoradiotherapy is safe and effective for Japanese patients with squamous cell carcinoma of the anal canal.
authors.affiliation: Dept. of Radiology, University of the Ryukyus Hospital, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Kinjo
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Shiro
authors.initials: S
authors.lastname: Iraha
authors.forename: Wakana
authors.initials: W
authors.lastname: Tamaki
authors.forename: Takafumi
authors.initials: T
authors.lastname: Toita
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Kakinohana
authors.forename: Hironori
authors.initials: H
authors.lastname: Samura
authors.forename: Izumi
authors.initials: I
authors.lastname: Kinjo
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nishimaki
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kuniyoshi
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Murayama
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003113:Colonoscopy; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged