title: High-resolution high-speed panoramic cardiac imaging system.
abstract: A panoramic cardiac imaging system consisting of three high-speed CCD cameras has been developed to image the surface electrophysiology of a rabbit heart via fluorescence imaging using a voltage-sensitive fluorescent dye. A robust, unique mechanical system was designed to accommodate the three cameras and to adapt to the requirements of future experiments. A unified computer interface was created for this application - a single workstation controls all three CCD cameras, illumination, stimulation, and a stepping motor that rotates the heart. The geometric reconstruction algorithms were adapted from a previous cardiac imaging system. We demonstrate the system by imaging a polymorphic cardiac tachycardia.
authors.affiliation: Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Dale W
authors.initials: DW
authors.lastname: Evertson
authors.forename: Mark R
authors.initials: MR
authors.lastname: Holcomb
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Eames
authors.forename: Mark-Anthony
authors.initials: MA
authors.lastname: Bray
authors.forename: Veniamin Y
authors.initials: VY
authors.lastname: Sidorov
authors.forename: Junkai
authors.initials: J
authors.lastname: Xu
authors.forename: Holley
authors.initials: H
authors.lastname: Wingard
authors.forename: Hana M
authors.initials: HM
authors.lastname: Dobrovolny
authors.forename: Marcella C
authors.initials: MC
authors.lastname: Woods
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Gauthier
authors.forename: John P
authors.initials: JP
authors.lastname: Wikswo
mesh_terms: D000465:Algorithms; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000503:physiopathology*; D018780:Body Surface Potential Mapping / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006329:Heart Conduction System / Q000503:physiopathology*; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D011817:Rabbits