title: Guest aggregation within poly(L-lactic acid)/pluronic P104 thin films.
abstract: Rhodamine 6G (R6G) doped thin films composed of poly(L-lactic acid) (PLLA) and Pluronic P104 were spin cast onto glass microscope slides and characterized by ultraviolet-visible, steady-state, and time-resolved fluorescence spectroscopy. The results show that R6G aggregation within the film increases as the R6G concentration and P104 loading increases. These results suggest an approach for studying drug distributions (monomers, aggregates) within biodegradable polymer formulations.
authors.affiliation: Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Steves
authors.forename: Loraine T
authors.initials: LT
authors.lastname: Tan
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Gardella
authors.forename: Robert
authors.initials: R
authors.lastname: Hard
authors.forename: Wesley L
authors.initials: WL
authors.lastname: Hicks
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Cartwright
authors.forename: Bahattan
authors.initials: B
authors.lastname: Koc
authors.forename: Frank V
authors.initials: FV
authors.lastname: Bright
mesh_terms: D000042:Absorption; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D020442:Poloxamer / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D012235:Rhodamines; C026188:rhodamine 6G; D020442:Poloxamer; D019344:Lactic Acid; C033616:poly(lactide)