Wnt/beta-catenin signaling: turning the switch.
The regulation of many targets of the Wnt/beta-catenin signaling pathway is thought to occur through a transcriptional switch that is achieved by beta-catenin binding to TCF transcription factors. Recent work indicates that beta-catenin's intrinsic affinity for TCF is not sufficient for the switch to occur.
Cadigan
Ken M
KM
Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. cadigan@umich.edu
D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D051820:TCF Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D015293:Transducin / Q000235:genetics / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
D009687:Nuclear Proteins; D034741:RNA, Small Interfering; D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; C119542:TBL1X protein, human; C473691:TBL1XR1 protein, human; D051820:TCF Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; D015293:Transducin