title: New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.
abstract: BACKGROUND
  Sequencing of the murine and human genomes has enabled large-scale functional genomics approaches to target identification. This holds the promise of drastically accelerating target discovery. Moreover, by providing an initial validation coincident with target identification, cell based cDNA or small interfering RNA (siRNA) screens and in particular genome-wide in vivo approaches, including forward or reverse genetics and analyses of natural gene polymorphisms, can move the relatively late step of target validation to the beginning of the process, reducing the risk of pursuing targets with little in vivo relevance.
  
  
  OBJECTIVE
  We critically discuss the value of combining functional genomics with traditional approaches for accelerating target identification and validation.
  
  
  METHODS
  We evaluate the potentials of inositol (1,4,5)trisphosphate 3-kinase B (ItpkB), Orai1 and UNC93B, three particularly interesting proteins that were recently identified through functional genomics, as targets in immune disorders.
  
  
  CONCLUSIONS
  Combining functional genomics with traditional approaches can accelerate target discovery and validation, but requires a follow-up platform that integrates and analyzes all relevant data for assessment of the clinical potential of the growing number of novel targets.
authors.affiliation: The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Yina H
authors.initials: YH
authors.lastname: Huang
authors.forename: Kasper
authors.initials: K
authors.lastname: Hoebe
authors.forename: Karsten
authors.initials: K
authors.lastname: Sauer
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D023281:Genomics; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D026901:Membrane Transport Proteins / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D000071740:ORAI1 Protein; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000187:drug effects* / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D026901:Membrane Transport Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C454130:UNC93B1 protein, human; D017853:Phosphotransferases (Alcohol Group Acceptor); C051038:Inositol 1,4,5-trisphosphate 3-kinase