Hereditary leiomyomatosis and renal cell carcinoma syndrome: a case report.
The simultaneous occurrence of multiple cutaneous leiomyomas, uterine leiomyomatosis, and renal cancer is described as a cancer syndrome with an autosomal dominant pattern of inheritance. We report a 79-year-old man who presented with multiple hyperkeratotic, erythematous nodules on his right leg with a histological diagnosis of pilar leiomyoma. In a review of systems, gross hematuria, weight loss, and bone pain were noted. His pathologic diagnosis was determined to be metastatic papillary renal cell carcinoma. A family history revealed that his sister had a hysterectomy for uterine leiomyomas. The findings in this case can be attributed to hereditary leiomyomatosis and renal cell carcinoma syndrome.
Hayedeh
Ghaninejad
G
Department of Dermatology, Razi Hospital ,Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh
Moeineddin
M
Ahmadreza
Rajaee
R
Masoud
Asgari
A
Ahmad
Salimzadeh
S
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D018231:Leiomyomatosis / Q000235:genetics*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D035781:Siblings; D012878:Skin Neoplasms / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics