Effectiveness of co-artemether in an unsupervised outpatient setting for the treatment of falciparum malaria.
OBJECTIVE
To assess artemether-lumefantrine effectiveness in the treatment of falciparum malaria in an unsupervised outpatient setting in Africa.


METHODS
Open label prospective study.


METHODS
Occupational health clinic, Mozambique.


METHODS
Semi-immune Mozambican adults.


METHODS
28-day treatment failures.


RESULTS
54/54 subjects were smear negative on day 2, and at 'day 28' (range 26-34 days).


CONCLUSIONS
Artemether-lumefantrine is effective in semi-immune adults in an unsupervised outpatient setting in Southern Africa, with no evidence of recrudescence.
Toovey
S
S
SAA-Netcare Travel Clinics, Johannesburg, South Africa. malaria@freesurf.ch
D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D023801:Directly Observed Therapy; D004338:Drug Combinations; D004983:Ethanolamines; D005260:Female; D005449:Fluorenes; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009073:Mozambique; D011446:Prospective Studies; D013997:Time Factors; D017211:Treatment Failure; D016896:Treatment Outcome
D000962:Antimalarials; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes