In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds.
A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.
Basaran
Ismet
I
Department of Chemistry, Balikesir University Science & Art Faculty, Balikesir, Turkey.
Sinan
Selma
S
Cakir
Umit
U
Bulut
Mustafa
M
Arslan
Oktay
O
Ozensoy
Ozen
O
D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors*; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors*; D003374:Coumarins / Q000494:pharmacology*; D003600:Cytosol / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics
D003374:Coumarins; D004791:Enzyme Inhibitors; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II