title: Multiple myeloma.
abstract: Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for the treatment of myeloma, as well as the development of new agents, is discussed. We also provide an update on current concepts of diagnosis and therapy, with an emphasis on how treatments have emerged from a historical perspective after certain important discoveries and the results of experimental studies.
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA. kyle.robert@mayo.edu
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kyle
authors.forename: S Vincent
authors.initials: SV
authors.lastname: Rajkumar
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000266:history* / Q000601:surgery / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D033581:Stem Cell Transplantation
chemical_list: D014408:Biomarkers, Tumor