Neuropeptide Y receptor-specifically modulates human neutrophil function.
Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species.
Bedoui
Sammy
S
Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Bedoui@wehi.edu.au
Kromer
Andreas
A
Gebhardt
Thomas
T
Jacobs
Roland
R
Raber
Kerstin
K
Dimitrijevic
Mirja
M
Heine
Jörn
J
von Hörsten
Stephan
S
D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D011869:Radioligand Assay; D017382:Reactive Oxygen Species / Q000378:metabolism; D017476:Receptors, Neuropeptide Y / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D009478:Neuropeptide Y; D017382:Reactive Oxygen Species; D017476:Receptors, Neuropeptide Y; D009240:N-Formylmethionine Leucyl-Phenylalanine