Interleukin 6-174 G/C promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1626 pregnant women.
OBJECTIVE
To investigate the frequency of the interleukin-6 (IL-6) -174 G/C single nucleotide polymorphism (SNP) in women with intrauterine fetal death (IUFD), pre-eclampsia (PE), preterm delivery (PD), and small for gestational age (SGA) infants.


METHODS
In a prospective cohort study, DNA from 1626 consecutive pregnant women was analyzed for IL-6 -174 G/C. Women who developed at least one of the predefined pregnancy complications were used as cases and compared with women without pregnancy complications.


RESULTS
Of 1626 women, 259 (15.9%) developed at least one pregnancy complication. IL-6 -174 G/C allele frequencies and genotype distributions were not significantly different between cases and controls. Similarly, no statistically significant difference in IL-6 -174 G/C genotype distribution in women with IUFD, PE, PD <34 weeks, PD >34 weeks and SGA infants <10th percentile was observed.


CONCLUSIONS
IL-6 -174 G/C is not a genetic marker for identifying women at increased risk of common pregnancy complications.
Stonek
Felix
F
Department of Obstetrics and Gynecology, Danube Hospital/SMZ-Ost, Vienna, Austria. felix.stonek@gmx.at
Metzenbauer
Martin
M
Hafner
Erich
E
Philipp
Karl
K
Tempfer
Clemens
C
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005313:Fetal Death / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D047928:Premature Birth / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D044465:White People
D015850:Interleukin-6