title: The molecular epidemiology of ocular Chlamydia trachomatis infections in Western Australia: implications for trachoma control.
abstract: We studied the serovar distribution of Chlamydia trachomatis in patients with clinical eye disease in Western Australia. Most disease occurred in indigenous communities and was caused by trachoma serovars Ba and C. Serovar Ba was genetically homogeneous throughout Western Australia and identical to strains previously described in indigenous communities in Northern Territory. This finding probably results from movement of these populations, and suggests that a widely coordinated, rather than local or regional, approach is needed to control trachoma in mobile populations. Serovar C strains within Western Australia were homogeneous but distinct from those in Northern Territory, possibly because of inherent differences in transmissibility or differences in population movements among communities carrying the different serovars. Genital serovars were occasional causes of eye diseases in infants, adolescents, and adults in trachoma-endemic areas. These serovars should be considered in the differential diagnosis of acute follicular conjunctivitis in these groups.
authors.affiliation: Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia. michelle.porter@health.wa.gov.au
authors.forename: Michelle
authors.initials: M
authors.lastname: Porter
authors.forename: Donna
authors.initials: D
authors.lastname: Mak
authors.forename: Glenys
authors.initials: G
authors.lastname: Chidlow
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Harnett
authors.forename: David W
authors.initials: DW
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000145:classification* / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D015818:Eye Infections, Bacterial / Q000453:epidemiology* / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D014141:Trachoma / Q000517:prevention & control*; D014904:Western Australia
chemical_list: D004269:DNA, Bacterial