Neurological complications of celiac disease and autoimmune mechanisms: a prospective study.
Humoral immune mechanisms may have a role in the neurological complications of celiac disease (CD). We assessed 71 CD patients for neurologic manifestations and presence of serum antibodies to neural antigens. Sixteen patients (22.5%) were found to have neurological deficits including headache, depression, entrapment syndromes, peripheral neuropathy, and epilepsy. Antibody reactivity to neural antigens was detected in 30/71 (42.2%) patients. There was no clear correlation between anti-neural reactivity and neurologic dysfunction. Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet.
Briani
Chiara
C
Department of Neurosciences, University of Padova, Padova, Italy. chiara.briani@unipd.it
Zara
Gabriella
G
Alaedini
Armin
A
Grassivaro
Francesca
F
Ruggero
Susanna
S
Toffanin
Elisabetta
E
Albergoni
Maria Paola
MP
Luca
Milena
M
Giometto
Bruno
B
Ermani
Mario
M
De Lazzari
Franca
F
D'Odorico
Anna
A
Battistin
Leontino
L
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000328:Adult; D000906:Antibodies / Q000097:blood; D001772:Blood Cell Count; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D019204:GTP-Binding Proteins; D005732:Gangliosides / Q000276:immunology; D005903:Gliadin / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000145:classification / Q000209:etiology* / Q000276:immunology*; D009431:Neural Conduction / Q000502:physiology; D011446:Prospective Studies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology
D000906:Antibodies; D005732:Gangliosides; D006680:HLA Antigens; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins