title: Toxic epidermal necrolysis with a rare long-term oral complication requiring surgical intervention.
abstract: BACKGROUND
  Toxic epidermal necrolysis (TEN) is a rare and potentially fatal adverse dermatologic reaction, often secondary to drug intake.
  
  
  RESULTS
  We report a case of an adult male who developed TEN that was complicated by a sepsis-induced coma lasting a period of 3 months. Although the patient eventually recovered, severe oral mucosal involvement during the course of disease resulted in frenum-like fibrotic bands that connected movable oral mucosa (tongue and lips) to attached oral mucosa (gingiva). This complication was painful and also affected his ability to speak and maintain adequate oral hygiene, requiring surgical intervention to restore structure and function.
  
  
  CONCLUSIONS
  This oral manifestation in relation to TEN is rarely reported in the literature and represents a preventable complication.
authors.affiliation: Division of Diagnostic Sciences and Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90089-0641, USA. sedghiza@usc.edu
authors.forename: Parish P
authors.initials: PP
authors.lastname: Sedghizadeh
authors.forename: Satish K S
authors.initials: SK
authors.lastname: Kumar
authors.forename: Amita
authors.initials: A
authors.lastname: Gorur
authors.forename: Christopher
authors.initials: C
authors.lastname: Mastin
authors.forename: Audrey L
authors.initials: AL
authors.lastname: Boros
mesh_terms: D001766:Blindness / Q000209:etiology; D001768:Blister / Q000209:etiology; D002921:Cicatrix / Q000150:complications / Q000601:surgery; D003128:Coma / Q000209:etiology; D006801:Humans; D007742:Labial Frenum / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000601:surgery; D013064:Speech Disorders / Q000209:etiology / Q000601:surgery; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome