[Pharmacological correction of neuronal damage in sensomotor zone of frontal cortex under conditions of experimental cerebral blood flow pathology].
The administration of thiotriazoline, emoxypine and magnelong (a combined glycine-magnesium preparation) to animals with acute cerebral circulatory insufficiency showed significant neuroprotective effect in both acute and late ischemic periods, as indicated by the indices of cell density and number and the characteristics of apoptic and destructed neurons approaching those in the group of intact rats. Pyracetam showed cerebroprotective effect only in late ischemic period. Magnelong exhibited the most significant neuroprotective effect, maintaining cell density on the intact control level and reducing the number of apoptotic and destructed neurons.
Gorbacheva
S V
SV
Belenichev
I F
IF
Dunaev
V V
VV
Bukhtiiarova
N V
NV
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology; D004338:Drug Combinations; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology; D005998:Glycine / Q000494:pharmacology; D015636:Magnesium Chloride / Q000494:pharmacology; D008297:Male; D009046:Motor Neurons / Q000187:drug effects* / Q000473:pathology; D009475:Neurons, Afferent / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000494:pharmacology
D004338:Drug Combinations; D018696:Neuroprotective Agents; D010847:Picolines; D014230:Triazoles; D015636:Magnesium Chloride; D005998:Glycine; C009820:6-methyl-2-ethyl-3-hydroxypyridine; D010889:Piracetam