title: Minimization of potential hERG liability in histamine H3 receptor antagonists.
authors.affiliation: Abbott Laboratories, GPRD Neuroscience Research, R4MN, AP9A-216, 100 Abbott Park Road, Abbott Park, IL 60064-6123, USA. larry.a.black@abbott.com
authors.forename: L A
authors.initials: LA
authors.lastname: Black
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: G J
authors.initials: GJ
authors.lastname: Diaz
authors.forename: G B
authors.initials: GB
authors.lastname: Fox
authors.forename: K E
authors.initials: KE
authors.lastname: Browman
authors.forename: J
authors.initials: J
authors.lastname: Wetter
authors.forename: K C
authors.initials: KC
authors.lastname: Marsh
authors.forename: T R
authors.initials: TR
authors.lastname: Miller
authors.forename: T A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: J
authors.initials: J
authors.lastname: Brioni
authors.forename: M D
authors.initials: MD
authors.lastname: Cowart
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001572:Benzofurans / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry; D054828:Histamine H3 Antagonists / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008297:Male; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry; D011869:Radioligand Assay; D051381:Rats; D018100:Receptors, Histamine H3 / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D000071230:Transcriptional Regulator ERG
chemical_list: D001572:Benzofurans; D003503:Cyclobutanes; C072312:ERG protein, human; D054828:Histamine H3 Antagonists; D009281:Naphthalenes; D018100:Receptors, Histamine H3; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG; C031721:naphthalene; C105430:benzofuran