title: Evaluation of catch-up growth from orthodontic treatment and supplemental growth hormone therapy by using Z-scores.
abstract: Pituitary dwarfism causes short stature due to partial or complete inhibition of growth hormone (GH) secretion. Supplemental therapy with human GH (rhGH) accelerates the statural growth of patients, but there is limited information about its effects on craniofacial growth. This study describes the orthodontic treatment of 2 patients (a boy and a girl) diagnosed with pituitary dwarfism and treated with rhGH therapy. Growing children have different growth velocities depending on age and sex, and this complicates the assessment of treatment effects; therefore, we used the Z-score to evaluate changes in stature and craniofacial components. Growth in craniofacial structures and stature were both enhanced by rhGH therapy during orthodontic treatment.
authors.affiliation: Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamashiro
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ando
authors.forename: Teruko
authors.initials: T
authors.lastname: Takano-Yamamoto
mesh_terms: D000293:Adolescent; D001827:Body Height; D002508:Cephalometry / Q000592:standards*; D002648:Child; D004393:Dwarfism, Pituitary / Q000150:complications / Q000188:drug therapy*; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008311:Malocclusion, Angle Class I / Q000150:complications / Q000628:therapy; D008445:Maxillofacial Development; D009971:Orthodontics, Corrective; D010155:Palatal Expansion Technique; D011994:Recombinant Proteins / Q000627:therapeutic use; D012015:Reference Standards
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone