[Some aspects of metabolic remodeling of myocard during chronic heart failure].
Review provides different mechanisms of "metabolic remodeling" of myocard during Chronic Heart Failure (CHF) including disorder of myocardial energy metabolism, changed activity of intracellular regulatory enzymes, metabolic activity of myocardial interstitium, different metabolic pathways leading to apoptosis of cardiomyocytes. The liquidation of results "metabolic remodeling"of myocardium prospects the new possibilities for development of pharmacological modulators of myocardial metabolic dysfunction in CHF.
Mamamtavrishvili
N
N
Tbilisi State University, Tbilisi, Georgia.
Sanikidze
T
T
Pavliashvili
N
N
Kvirkvelia
A
A
Narsia
E
E
D002908:Chronic Disease; D006333:Heart Failure / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D020257:Ventricular Remodeling / Q000502:physiology*