Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships.
Utilizing linear solvation free energy relationship methodology, a novel pyridinium bromide surface confined ionic liquid (SCIL) stationary phase was characterized under normal phase high-performance liquid chromatographic conditions. A limited set of neutral aromatic probe solutes were utilized to rapidly assess the utility of the LSER model, using mobile phases of hexane modified with 2-propanol. The excellent correlation of the global fit across the mobile phase composition range used in this study for the experimental and calculated retention values (R(2)=0.994) indicates that the LSER model is an appropriate model of characterizing this polar bonded phase under normal phase conditions. For a limited subset of compounds, retention on the pyridinium bromide SCIL stationary phase is more highly correlated with that obtained on a cyano column than on a diol column under NP conditions.
Van Meter
D S
DS
Department of Chemistry, PO Box 210172, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Stuart
O D
OD
Carle
A B
AB
Stalcup
A M
AM
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D011726:Pyridinium Compounds / Q000737:chemistry*; D013816:Thermodynamics
D011726:Pyridinium Compounds