title: Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate.
abstract: In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [(3)H]PGE(2) transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver.
authors.affiliation: Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan.
authors.forename: Rafiqul
authors.initials: R
authors.lastname: Islam
authors.forename: Naohiko
authors.initials: N
authors.lastname: Anzai
authors.forename: Nesar
authors.initials: N
authors.lastname: Ahmed
authors.forename: Babu
authors.initials: B
authors.lastname: Ellapan
authors.forename: Chun Ji
authors.initials: CJ
authors.lastname: Jin
authors.forename: Sunena
authors.initials: S
authors.lastname: Srivastava
authors.forename: Daisaku
authors.initials: D
authors.lastname: Miura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fukutomi
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Kanai
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Endou
mesh_terms: D000818:Animals; D001692:Biological Transport; D015232:Dinoprostone / Q000378:metabolism; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D051379:Mice; D029362:Organic Anion Transporters, Sodium-Independent / Q000502:physiology*; D011422:Propionates / Q000378:metabolism*; D014981:Xenopus
chemical_list: D005232:Fatty Acids, Volatile; D029362:Organic Anion Transporters, Sodium-Independent; D011422:Propionates; C490281:Slc22a7 protein, mouse; D015232:Dinoprostone