[Radionuclide diagnosis of functional pulmonary disorders in outpatient setting].
OBJECTIVE
To define informative value of a novel technique in radionuclide examination of microcirculatory and alveolar ventilation disorders in pulmonary diseases and to test its application possibilities in outpatient practice.


METHODS
Perfusion static scintigraphy of the lungs with 99m-Tc-macrotech and ventilatory aerosol dynamic and static pulmonary scintigraphy after 99m-Tc-pentatech (DTPA analogue) inhalation were performed in 128 patients with bronchial asthma (BA), chronic obstructive bronchitis (COB) and pulmonary abscess.


RESULTS
Regional perfusion and ventilation were abnormal in all the examinees with BA and COB including in lower zones of both the lungs characteristic of pulmonary emphysema. In COB ventilation-perfusion correlations were disturbed in both lungs in 87.5%, in one lung in 100% patients. In BA patients after the attack the results of ventilatory pulmonary scintigraphy should be evaluated visually (qualitatively). In pulmonary abscess regional disorders of perfusion and/or ventilation were seen in 94.6%, lack of balance V/Q in the focal zone--in 75%, in the whole affected lung--in 55.4% patients. Compensatory synchrony of ventilation-perfusion relations in impaired regional indices V/Q took place in COB patients in 37.5%, in abscess (in the affected lung)--in 42.9%. Acceleration and delay of alveolar-capillary diffusion were detected in bronchial asthma in 76.5%, COB--in 68.7%, in abscess in the affected lung--in 48.8%, in the contralateral lung--in 56.5%.


CONCLUSIONS
Lung lesion can be assessed with ventilation-perfusion correlations and clearance of 99mTc-pentatech from the right and left lung.
Rubin
M P
MP
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D008169:Lung Abscess / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D015203:Reproducibility of Results
D003287:Contrast Media; D019786:Gadolinium DTPA