Obsessive-compulsive disorder: influence of age at onset on comorbidity patterns.
OBJECTIVE
This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset.


METHODS
Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis.


RESULTS
Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cut-off age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample.


CONCLUSIONS
Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value.
de Mathis
Maria Alice
MA
Department of Psychiatry, University of Sao Paulo Medical School, Rua Dr. Ovídio Pires de Campos, 785, 05403-010 São Paulo, SP, Brazil. alicedemathis@gmail.com
do Rosario
Maria Conceição
MC
Diniz
Juliana Belo
JB
Torres
Albina Rodrigues
AR
Shavitt
Roseli Gedanki
RG
Ferrão
Ygor Arzeno
YA
Fossaluza
Victor
V
de Bragança Pereira
Carlos Alberto
CA
Miguel
Eurípedes Constantino
EC
D000328:Adult; D017668:Age of Onset; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001938:Brazil; D015897:Comorbidity; D003430:Cross-Sectional Studies; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001068:Feeding and Eating Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D010552:Personality Assessment; D012737:Sex Factors; D013001:Somatoform Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D013981:Tic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology