title: Risk factors for hepatitis C virus infection among blood donors in Beijing and implications for improving the pretesting donor screening process.
abstract: BACKGROUND
  The objective was to determine risk factors of hepatitis C virus (HCV) infection in blood donors in Beijing.
  
  
  METHODS
  A cross-sectional study was conducted in a total of 112 volunteer blood donors at Beijing Red Cross Blood Center (BRCBC) who were identified between January 2002 and December 2003 due to isolated HCV antibody reactivity at a donor screening procedure. The donors were recalled and interviewed about possible risk factor history. Additional blood samples were tested in repeated enzyme immunoassay, recombinant immunoblot assay, and nested reverse transcription-polymerase chain reaction. Chi-square test, analysis of variance, and multivariate logistic regression analysis were conducted to examine associations between HCV serostatus and potential risk factors.
  
  
  RESULTS
  Among donors identified with isolated HCV antibody reactivity at donor screening, the prevalence of confirmed HCV infection was 31.3 percent (95% confidence interval [CI], 22.0%-39.2%) and indeterminate HCV infection was 22.3 percent (95% CI, 14.7%-30.3%), and the negative prevalence was 46.4 percent (95% CI, 37.5%-56.1%). The confirmed HCV cases were more likely than the indeterminate HCV cases to have the histories of previous transfusion, plasma donation, and hepatitis infection or elevated alanine aminotransferase (ALT), whereas the HCV-negative subjects were least likely to have the above histories (p < 0.05).
  
  
  CONCLUSIONS
  Histories of blood transfusion before 1995, plasma donation, previous hepatitis infection, or elevated ALT were risk factors for HCV infection among blood donors in Beijing.
authors.affiliation: Beijing Red Cross Blood Center, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Ling
authors.initials: L
authors.lastname: Shi
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Gui
authors.initials: G
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Gong
authors.forename: Hongying
authors.initials: H
authors.lastname: Xia
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Paul
authors.initials: P
authors.lastname: Ness
authors.forename: Hua
authors.initials: H
authors.lastname: Shan
mesh_terms: D002681:China / Q000453:epidemiology; D046148:Donor Selection; D005260:Female; D006526:Hepatitis C / Q000097:blood* / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D008297:Male; D012307:Risk Factors