title: Epidural analgesia after scoliosis surgery: electrophysiologic and clinical assessment of the effects of bupivacaine 0.125% plus morphine versus ropivacaine 0.2% plus morphine.
abstract: OBJECTIVE
  To study the electrophysiologic and clinical effects of epidural morphine combined with either bupivacaine 0.125% or ropivacaine 0.2%.
  
  
  METHODS
  Comparative, randomized, double-blind study.
  
  
  METHODS
  Intensive care unit and hospital ward of a university hospital.
  
  
  METHODS
  18 adult ASA physical status I and II patients with degenerative or idiopathic scoliosis, undergoing posterior spinal fusion with instrumentation.
  
  
  METHODS
  Patients received epidural administration of 10-mL bolus of either bupivacaine or ropivacaine followed by a 6-mL/h infusion for 48 hours of unlabeled local anesthetic. In all patients, epidural morphine 5 mg was added daily.
  
  
  METHODS
  Assessment was focused mainly on somatosensory cortical evoked potentials, soleus H-reflex, and F waves. These electrophysiologic data were recorded before and after epidural medications. Second, respiratory rate, Paco(2), visual analog score (VAS), and side effects such as postoperative nausea and vomiting (PONV), gastrointestinal (GI) transit delay, and urinary retention were noted.
  
  
  RESULTS
  Bupivacaine 0.125% + morphine was given to 9 patients, and ropivacaine 0.2% + morphine was given to 9 other patients. H-reflex, F waves, and somatosensory cortical evoked potential recording remained unchanged across the time of assessment. Respiratory rate and Paco(2) values were normal. VASs were indifferently low at rest, but they were lower with bupivacaine than with ropivacaine on mobilization. The frequency of PONV was indifferently high. No altered GI transit or urinary retention was noted.
  
  
  CONCLUSIONS
  After epidural administration during the study conditions, bupivacaine 0.125% and ropivacaine 0.2% combined with morphine allow for neurologic examination.
authors.affiliation: Hôtel-Dieu, University Hospital of Nantes, 44093 France. charles.phamdang@chu-nantes.fr
authors.forename: Charles
authors.initials: C
authors.lastname: Pham Dang
authors.forename: Joël
authors.initials: J
authors.lastname: Delécrin
authors.forename: Yann
authors.initials: Y
authors.lastname: Péréon
authors.forename: Isabelle
authors.initials: I
authors.lastname: Falconi
authors.forename: Norbert
authors.initials: N
authors.lastname: Passuti
authors.forename: Myriam
authors.initials: M
authors.lastname: Malinge
authors.forename: Michel
authors.initials: M
authors.lastname: Pinaud
mesh_terms: D000328:Adult; D000577:Amides / Q000494:pharmacology*; D015360:Analgesia, Epidural; D000777:Anesthetics / Q000494:pharmacology; D002045:Bupivacaine / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D011183:Postoperative Complications; D011446:Prospective Studies; D000077212:Ropivacaine; D012600:Scoliosis / Q000601:surgery*
chemical_list: D000577:Amides; D000777:Anesthetics; D009020:Morphine; D000077212:Ropivacaine; D002045:Bupivacaine