title: Innate recognition of non-self nucleic acids.
abstract: The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.
authors.affiliation: Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. hongbo.chi@stjude.org
authors.forename: Hongbo
authors.initials: H
authors.lastname: Chi
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D003600:Cytosol / Q000276:immunology; D004247:DNA / Q000276:immunology*; D011992:Endosomes / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D012313:RNA / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000502:physiology*
chemical_list: D051192:Receptors, Pattern Recognition; D012313:RNA; D004247:DNA