Benzophenone C-glucosides from Polygala glomerata Lour.
Four new benzophenone C-glucosides, glomeratides A (1), B (2), C (3), and D (4), along with a known compound arrilanin G (5), have been isolated from the whole plant of Polygala glomerata Lour. Their structures were determined by extensive analyses of their spectral data. Compounds 1-5 showed hepatoprotective activities against d-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
Li
Chuang-Jun
CJ
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang
Dong-Ming
DM
Yu
Shi-Shan
SS
D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010936:Plant Extracts / Q000737:chemistry; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D001577:Benzophenones; D005960:Glucosides; D010936:Plant Extracts