title: Cytologic differentiation of struma ovarii from other ovarian neoplasms.
abstract: OBJECTIVE
  To present the cytologic findings of struma ovarii and value of cytology and immunocytochemistry (ICC) using thyroglobulin (TGB) and thyroid transcription factor-1 (TTF-1) in evaluation of this unusual ovarian neoplasm, together with the diagnostic pitfalls.
  
  
  METHODS
  Intraoperative cytologic findings of 7 patients with struma ovarii are reviewed. Cytologic material of both cystic and solid components was collected intraoperatively. ICC staining was done, and cell block preparation performed on selected cases.
  
  
  RESULTS
  The cases were divided in to 3 groups: group 1--diagnosis of struma ovarii was made by cytology and confirmed by ICC (1 case); group 2--diagnosis was suggestive on cytology or cell block and confirmed by ICC staining (4 cases); group 3--on cytologic diagnosis indistinguishable from other cystic ovarian neoplasms (2 cases). Cytologic findings were typically colloid with mosaic pattern, follicles, follicular cells only, sheets of follicular cells, both colloid and follicular cells, proteinaceous background or degenerated epithelial cells indistinguishable from other cystic ovarian neoplasms.
  
  
  CONCLUSIONS
  Cytologic findings of struma ovarii are distinct enough to be suggested intraoperatively, and ICC for TGB or TTF-1 is a valuable tool for preoperative fine needle aspiration biopsy and intraoperative diagnosis of this benign ovarian neoplasm.
authors.affiliation: Cytopathology and Hematopathology Department, Dr. Daneshbod Pathology Laboratory, Shiraz, Iran. daneshbk@yahoo.com
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
authors.forename: Khosrow
authors.initials: K
authors.lastname: Daneshbod
authors.forename: Ali-Reza
authors.initials: AR
authors.lastname: Rasekhi
authors.forename: Ziba
authors.initials: Z
authors.lastname: Mosayebi
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Negahban
authors.forename: Saeed-Reza
authors.initials: SR
authors.lastname: Hodjati
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Bedayat
authors.forename: Parvin
authors.initials: P
authors.lastname: Ganjei-Azar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013330:Struma Ovarii / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013954:Thyroglobulin / Q000378:metabolism; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D013954:Thyroglobulin