Prevention of chemotherapy-induced alopecia in rodent models.
Alopecia (hair loss) is experienced by thousands of cancer patients every year. Substantial-to-severe alopecia is induced by anthracyclines (e.g., adriamycin), taxanes (e.g., taxol), alkylating compounds (e.g., cyclophosphamide), and the topisomerase inhibitor etoposide, agents that are widely used in the treatment of leukemias and breast, lung, ovarian, and bladder cancers. Currently, no treatment appears to be generally effective in reliably preventing this secondary effect of chemotherapy. We observed in experiments using different rodent models that localized administration of heat or subcutaneous/intradermal injection of geldanamycin or 17-(allylamino)-17-demethoxygeldanamycin induced a stress protein response in hair follicles and effectively prevented alopecia from adriamycin, cyclophosphamide, taxol, and etoposide. Model tumor therapy experiments support the presumption that such localized hair-saving treatment does not negatively affect chemotherapy efficacy.
Jimenez
Joaquin J
JJ
Department of Medicine, University of Miami, Miami, FL, USA.
Roberts
Stephen M
SM
Mejia
Jessica
J
Mauro
Lucia M
LM
Munson
John W
JW
Elgart
George W
GW
Connelly
Elizabeth Alvarez
EA
Chen
Qingbin
Q
Zou
Jiangying
J
Goldenberg
Carlos
C
Voellmy
Richard
R
D000505:Alopecia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D016227:Benzoquinones / Q000008:administration & dosage / Q000627:therapeutic use*; D016466:CHO Cells / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D047029:Lactams, Macrocyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D015854:Up-Regulation / Q000187:drug effects
D000970:Antineoplastic Agents; D016227:Benzoquinones; D006360:Heat-Shock Proteins; D047029:Lactams, Macrocyclic; C112765:tanespimycin; C001277:geldanamycin