title: Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review.
abstract: For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor. A new assay that detects antibodies to citrullinated peptides, called the anti-CCP assay, has demonstrated a comparable sensitivity but a much higher specificity than the RF test. This paper reviews RF and anti-CCP in rheumatoid arthritis and examines the usefulness of each autoantibody in RA testing.
authors.affiliation: University of Southern Mississippi, Hattiesburg, MS, USA. starsweeper18@hotmail.com
authors.forename: Ashley Nicole
authors.initials: AN
authors.lastname: Lee
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Beck
authors.forename: Margot
authors.initials: M
authors.lastname: Hall
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D007155:Immunologic Factors / Q000097:blood*; D010456:Peptides, Cyclic / Q000276:immunology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012217:Rheumatoid Factor / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D001323:Autoantibodies; D007155:Immunologic Factors; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor