Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis.
Kaposi's sarcoma (KS)-associated herpesvirus is associated with the proliferative/malignant disorders KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD) in patients with AIDS. In spite of recent advances in the treatment of KS, PEL and MCD represent therapeutic challenges. Recent advances in dissecting the pathogenesis of these diseases have indicated that the viral cytokine IL-6 and the cellular cytokines/growth factors IL-10, IL-6, stromal cell-derived factor 1, and vascular endothelial growth factor are important contributors to the growth, survival, and spread of PEL and MCD and are therefore potential targets for drug development.
Gasperini
Paola
P
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Sakakibara
Shuhei
S
Tosato
Giovanna
G
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D002455:Cell Division; D002470:Cell Survival; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D012514:Sarcoma, Kaposi / Q000150:complications / Q000276:immunology* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology
D016207:Cytokines; D015850:Interleukin-6; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10