title: Clinical and histological findings in nephrogenic systemic fibrosis.
abstract: Nephrogenic systemic fibrosis (NSF) is a relative newcomer to the world of medicine. NSF was introduced just over 10 years ago as nephrogenic fibrosing dermopathy, but with further investigation, its systemic nature was determined. The strict adherence to a definition requiring both clinical and pathological concordance has allowed for careful separation of this entity from other fibrosing disorders, leading eventually to the realization that gadolinium-based contrast agents were closely associated with its onset. As planned prospective studies get underway, it is of paramount importance that researchers and clinicians realize that NSF remains a very challenging diagnosis, and that both clinical and histopathological criteria must be employed to reach the most accurate diagnosis possible.
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
authors.forename: Shawn E
authors.initials: SE
authors.lastname: Cowper
authors.forename: Morgan
authors.initials: M
authors.lastname: Rabach
authors.forename: Michael
authors.initials: M
authors.lastname: Girardi
mesh_terms: D003287:Contrast Media / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005355:Fibrosis / Q000139:chemically induced / Q000473:pathology; D005682:Gadolinium / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008279:Magnetic Resonance Imaging; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D003287:Contrast Media; D005682:Gadolinium