Rapid report on methodology: does loss to follow-up in a cohort study bias associations between early life factors and lifestyle-related health outcomes?
OBJECTIVE
To examine the consequences of non-response in a follow-up survey for associations between early-life factors and lifestyle-related health outcomes in adulthood.


METHODS
In a cohort of 11532 Danish men born in 1953 we had nearly complete follow-up in the National Patient Register, but only 66% of 9507 eligible cohort members participated in a follow-up survey, in 2004. We examined whether characteristics measured early in life and discharge from hospital for alcohol abuse or tobacco-related lung diseases, were associated with survey response. Associations between the early-life characteristics and these two health outcomes were calculated in the entire cohort and among responders, and the effect of non-response was described by a Relative Odd Ratio (ROR=OR(responders)/OR(entire cohort)).


RESULTS
A low response rate at age 50 years was related to having a single mother at birth, low educational attainment at age 18, and low cognitive function at ages 12 and 18. The risk of alcohol overuse and tobacco-related diseases was also highest among non-responders. However, the associations between early-life characteristics and the outcomes were nearly the same in responders as in the entire cohort.


CONCLUSIONS
Although non-responders differed from responders in terms of early-life exposures and incidence of the lifestyle-related outcomes, we found no overt effects of this on the exposure-risk associations.
Osler
Merete
M
Department of Epidemiology, University of Southern Denmark. m.osler@pubhealth.ku.dk
Kriegbaum
Margit
M
Christensen
Ulla
U
Holstein
Bjørn
B
Nybo Andersen
Anne-Marie
AM
D003071:Cognition; D015331:Cohort Studies; D003718:Denmark; D004812:Epidemiologic Methods; D005191:Family Characteristics; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010352:Patient Dropouts; D035842:Research Subjects; D015983:Selection Bias