Identification and characterization of mouse type II platelet-derived growth factor receptor alpha transcript.
Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor alpha mRNA (type II) that differs from the known human PDGF receptor alpha mRNA (type I) only in its 5'-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor alpha mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.
Minato
Yusuke
Y
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
Nihei
Yoshiaki
Y
Kodama
Yuki
Y
Tashiro
Etsu
E
Kanai
Mai
M
Imoto
Masaya
M
D000818:Animals; D001483:Base Sequence; D050687:E2F1 Transcription Factor / Q000502:physiology*; D004622:Embryo, Mammalian; D005786:Gene Expression Regulation; D051379:Mice; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics* / Q000302:isolation & purification; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D020218:Response Elements; D014158:Transcription, Genetic
D050687:E2F1 Transcription Factor; C493754:E2f1 protein, mouse; D012333:RNA, Messenger; D020796:Receptor, Platelet-Derived Growth Factor alpha