Chemical constituents with antibacterial activity from Euphorbia sororia.
A group of ceramide (1) was isolated from the aerial parts of Euphorbia sororia. On the basis of spectroscopic data, chemical methods and GC-MS analysis, the structure of 1 was characterised as (2S,3S,4R,8E)-2-(eicosanoyl approximately octacosanoyl amino)-1,3,4-octadecanetriol-8-ene. In addition, four known ellagic acid derivatives 3,3'-di-O-methylellagic acid (2), 3,3',4'-tri-O-methylellagic acid (3), 4-O-sulfooxy-3,3'-di-O-methylellagic acid (4) and 4-O-sulfooxy- 3,3',4'-tri-O-methylellagic acid (5) were isolated from the plant. Biological screening of all compounds revealed moderate antibacterial activity.
Zhang
Wei-Ku
WK
Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Xu
Jie-Kun
JK
Zhang
Xiao-Qi
XQ
Yao
Xin-Sheng
XS
Ye
Wei-Cai
WC
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002518:Ceramides / Q000737:chemistry* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D002518:Ceramides