title: Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men.
abstract: The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Gray
authors.forename: M
authors.initials: M
authors.lastname: Robinson
authors.forename: M A
authors.initials: MA
authors.lastname: Nimmo
mesh_terms: D000328:Adult; D001810:Blood Volume; D050822:Cytokine Receptor gp130 / Q000096:biosynthesis / Q000097:blood*; D005080:Exercise Test; D005221:Fatigue / Q000097:blood; D006339:Heart Rate; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood*; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D010101:Oxygen Consumption; D005082:Physical Exertion; D019947:Receptors, Interleukin-6 / Q000096:biosynthesis / Q000097:blood*; D012995:Solubility
chemical_list: C508600:IL6 protein, human; C508603:IL6R protein, human; C494199:IL6ST protein, human; D015850:Interleukin-6; D007773:Lactates; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130