title: [External radiotherapy and photodynamic therapy for esophageal carcinoma: a dangerous association?].
abstract: A 60-year-old man presented an oesophageal transmural necrosis fistulised in the trachea following curative photodynamic therapy (PDT) for a superficial recurrence of an oesophageal carcinoma, initially treated by radiochemotherapy. Two stents, a tracheal and an oesophageal one, were placed. Eight months later the patient is in complete remission with only mild swallowing problems. This complication, although unusual, has already been described by other teams with the association of radiochemotherapy and PDT. The present case study suggests that illumination dose should be lowered in this indication.
authors.affiliation: Département d'hépatogastroentérologie, CHU de Grenoble, B.P. 217, 38043 Grenoble, France. mbaconnier@chu-grenoble.fr
authors.forename: M
authors.initials: M
authors.lastname: Baconnier
authors.forename: J-M
authors.initials: JM
authors.lastname: Phélip
authors.forename: E
authors.initials: E
authors.lastname: Germain
authors.forename: A
authors.initials: A
authors.lastname: Durand
authors.forename: J
authors.initials: J
authors.lastname: Balosso
authors.forename: P
authors.initials: P
authors.lastname: Bichard
authors.forename: X
authors.initials: X
authors.lastname: Roblin
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D017323:Dihematoporphyrin Ether / Q000009:adverse effects; D004938:Esophageal Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000009:adverse effects; D018714:Radiotherapy, Adjuvant; D015607:Stents; D014138:Tracheoesophageal Fistula / Q000209:etiology* / Q000473:pathology / Q000601:surgery
chemical_list: D017319:Photosensitizing Agents; D017323:Dihematoporphyrin Ether