[Overweight in adolescent offspring of women with hyperglycemia during pregnancy].
OBJECTIVE
To verify whether different hyperglycemia levels during pregnancy cause frequency differences in adolescent obesity and its morbidities in the offspring.


METHODS
Seventy-three children were divided into three groups according to maternal glucose tolerance: G1 (n=27) normal oral glucose tolerance test (OGTT) and daily glycemia (DG); G2 (n=23) normal OGTT and high DG; G3 (n=23) abnormal OGTT and DG (gestational diabetes mellitus; GDM). All underwent clinical evaluation (anthropometry) a questionnaire(neonatal data, eating habits), and determination of fasting serum glucose and lipid profile measurement. Analysis of variance (ANOVA) and the Goodmans test were used to compare the groups.


RESULTS
G3 mothers showed higher fasting plasma glucose(FPG) and DG than G2 and G1(FPG: 93+/-10 vs 83+/-5 vs 78+/-10 mg/dL; DG: 104+/-12 vs 93+/-7 vs 85+/-9 mg/dL, respectively; P<0.001). G2 mothers had higher DG than G1 (93+/-7 vs 85+/-9 mg/dL; P<0.001). G3 offspring birthweight was higher than G1 and G2 (3,667+/-527 vs 3,167+/-565 and 3,282+/-401 g, respectively; P<0.05). More G3 offspring were overweight than G1 (52.2 vs 14.8%; P<0.05).


CONCLUSIONS
Offspring of GDM mothers with fasting and daily hyperglycemia have higher birthweight and overweight frequency in adolescence. These children must be followed up from infancy.
Buzinaro
Elizabeth Fernandes
EF
Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Berchieri
Carolina Bragiola
CB
Haddad
Adriana Lúcia Mendes
AL
Padovani
Carlos Roberto
CR
Pimenta
Walkyria de Paula
Wde P
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002648:Child; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications*; D007231:Infant, Newborn; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose