Tat-SIRT1 tango.
In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
Blazek
Dalibor
D
Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, CA 94143-0703, USA.
Peterlin
B Matija
BM
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000818:Animals; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000235:genetics / Q000378:metabolism*
D016328:NF-kappa B; D054322:tat Gene Products, Human Immunodeficiency Virus; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins