Effects of a Dictamnus dasycarpus T. extract on allergic models in mice.
The anti-allergic effect of a 70% ethanol extract from Dictamnus dasycarpus Turcz (DDT) was studied in mice. DDT at doses of 200 and 500 mg/kg inhibited the systemic anaphylactic shock induced by compound 48/80 in a dose-dependent manner. It also inhibited dose-dependently the scratching behavior induced by compound 48/80, histamine and serotonin. An increase in the vascular permeability induced by compound 48/80, histamine and serotonin was also inhibited by DDT. In an in vitro study, DDT inhibited the histamine released from rat peritoneal mast cells induced by compound 48/80. It seems likely from these findings that DDT was effective in antagonizing certain pharmacological effects induced by compound 48/80 that occurred via both histamine and serotonin released from mast cells. In conclusion, DDT may be effective in the relief of symptoms of allergic atopic dermatitis and other allergy-related diseases.
Jiang
Shuishi
S
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan.
Nakano
Yoshiyuki
Y
Rahman
Mohamed Ashequr
MA
Yatsuzuka
Rie
R
Kamei
Chiaki
C
D000818:Animals; D036905:Dictamnus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000378:metabolism; D006967:Hypersensitivity / Q000188:drug therapy*; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011537:Pruritus / Q000517:prevention & control; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine
D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine