title: Helical tomotherapy as a new treatment technique for whole abdominal irradiation.
abstract: OBJECTIVE
  To describe a new intensity-modulated radiotherapy (IMRT) technique using helical tomotherapy for whole abdominal irradiation (WAI) in patients with advanced ovarian cancer.
  
  
  METHODS
  A patient with radically operated ovarian cancer FIGO stage IIIc was treated in a prospective clinical trial with WAI to a total dose of 30 Gy in 1.5-Gy fractions as an additional therapy after adjuvant platinum-based chemotherapy. The planning target volume (PTV) included the entire peritoneal cavity. PTV was adapted according to breathing motion as detected in a four-dimensional respiratory-triggered computed tomography (4D-CT). Inverse treatment planning was done with the Hi-Art tomotherapy planning station. Organs at risk (OARs) were kidneys, liver, bone marrow, spinal cord, thoracic and lumbosacral vertebral bodies, and pelvic bones. Daily control of positioning accuracy was performed with megavoltage computed tomography (MV-CT).
  
  
  RESULTS
  Helical tomotherapy enabled a very homogeneous dose distribution with excellent sparing of OARs and coverage of the PTV (V90 of 93.1%, V95 of 86.9%, V105 of 1.9%, and V110 of 0.01%). Mean liver dose was 21.57 Gy and mean kidney doses were 9.75 Gy and 9.14 Gy, respectively. Treatment could be performed in 18.1 min daily and no severe side effects occurred.
  
  
  CONCLUSIONS
  Helical tomotherapy is feasible and fast for WAI. Tomotherapy enabled excellent coverage of the PTV and effective sparing of liver, kidneys and bone marrow.
authors.affiliation: Department of Radiation Oncology, University of Heidelberg, Germany. nathalie.rochet@med.uni-heidelberg.de
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rochet
authors.forename: Florian
authors.initials: F
authors.lastname: Sterzing
authors.forename: Alexandra
authors.initials: A
authors.lastname: Jensen
authors.forename: Julien
authors.initials: J
authors.lastname: Dinkel
authors.forename: Klaus
authors.initials: K
authors.lastname: Herfarth
authors.forename: Kai
authors.initials: K
authors.lastname: Schubert
authors.forename: Michael
authors.initials: M
authors.lastname: Eichbaum
authors.forename: Andreas
authors.initials: A
authors.lastname: Schneeweiss
authors.forename: Christof
authors.initials: C
authors.lastname: Sohn
authors.forename: Juergen
authors.initials: J
authors.lastname: Debus
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Harms
mesh_terms: D000005:Abdomen / Q000528:radiation effects*; D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D001853:Bone Marrow / Q000528:radiation effects; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D010053:Ovary / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D013997:Time Factors; D036542:Tomography, Spiral Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D016190:Carboplatin; D017239:Paclitaxel