title: Elasticity reconstruction from displacement and confidence measures of a multi-compressed ultrasound RF sequence.
abstract: Ultrasound elasticity imaging shows promise as a new way for early detection of cancers by assessing the elastic characteristics of soft tissue. So far the commonly used approach involves solving the so-called inverse elasticity problem of recovering elastic parameters from displacement measurements. We propose a finite-elementbased nonlinear scheme to estimate the elasticity distribution of soft tissue from multi-compressed ultrasound radio frequency (RF) data. An experimental ultrasound workstation has been developed to acquire multi-compressed data. A composite probe was employed as the compression plate. The contact forces and torques were acquired at the same time as imaging. Axial displacements under different static loads are estimated from the RF data before and after deformation using a cross-correlation technique. The confidence of displacement estimates is employed as a weighting factor in solving the objective function describing the inverse elasticity reconstruction problem. A novel splitand- merge strategy is employed over the image sequence in which strain images are used to provide a priori knowledge of the relative stiffness distribution of the tissue to constrain the inverse problem solution. The experimental study has allowed us to investigate the performance of our approach in the controlled environment of simulated and phantom data. For a simulated single inclusion model with 5% axial displacement estimation error, the L2-error between the target and the reconstructed Young's modulus was found to be about 1%. In vivo validation of the proposed method has been carried out and some preliminary results are presented.
authors.affiliation: Wolfson Medical Vision Laboratory, Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, UK. larry@robots.ox.ac.uk
authors.forename: Junbo
authors.initials: J
authors.lastname: Li
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Cui
authors.forename: Michael
authors.initials: M
authors.lastname: Kadour
authors.forename: J Alison
authors.initials: JA
authors.lastname: Noble
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D003198:Computer Simulation; D003238:Connective Tissue / Q000000981:diagnostic imaging* / Q000502:physiology*; D044962:Data Compression / Q000379:methods*; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008954:Models, Biological; D011846:Radio Waves; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013314:Stress, Mechanical