Transfer of maternal colostral leukocytes promotes development of the neonatal immune system I. Effects on monocyte lineage cells.
Although it has been established that maternal leukocytes traffic from colostrum into the neonatal circulation, the effects of these cells on neonatal immunity are only beginning to be understood. This study examined the effects of maternal colostral leukocytes on development and maturation of neonatal antigen presenting cells. At birth, groups of neonatal calves received whole or cell-free colostrum (CFC) from their respective dams. Peripheral blood samples were obtained over the first 4 weeks of life, and expression of surface markers associated with cellular activation and physiological stress were monitored on monocyte lineage cells. Calves receiving cell-free colostrum at birth expressed elevated levels of CD11a, CD11c, and CD14, compared to calves receiving whole colostrum (C). Calves receiving cell-free colostrum had an elevated number of monocytes in the peripheral blood during the first 2 weeks of life, however, these cells expressed lower levels of expression of CD25 and MHC class I compared to calves receiving whole colostrum. The most significant differences in marker expression occurred within the first 7 days of life.
Reber
A J
AJ
Food Animal Health and Management Program, The Department of Population Health, University of Georgia, Athens, GA 30602, USA.
Donovan
D C
DC
Gabbard
J
J
Galland
K
K
Aceves-Avila
M
M
Holbert
K A
KA
Marshall
L
L
Hurley
D J
DJ
D000818:Animals; D000831:Animals, Newborn; D017951:Antigen Presentation; D040881:CD11a Antigen / Q000096:biosynthesis / Q000097:blood; D039521:CD11c Antigen / Q000096:biosynthesis / Q000097:blood; D002417:Cattle / Q000097:blood / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology; D003126:Colostrum / Q000166:cytology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D016130:Immunophenotyping / Q000662:veterinary; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis / Q000097:blood
D040881:CD11a Antigen; D039521:CD11c Antigen; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G; D018950:Lipopolysaccharide Receptors; D009569:Nitric Oxide