Lung transplantation in a patient with a thrombophilic disorder.
The prothrombin G20210A mutation has been associated with an increased risk of graft failure in renal transplant recipients. Little is known about the potential effect of this mutation on lung transplant recipients. We report the case of bilateral lung transplantation in a patient with cystic fibrosis who was heterozygous for the G20210A mutation of the prothrombin gene.
Elidemir
O
O
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. oxelidem@texaschildrenshospital.org
Smith
K J
KJ
Schecter
M G
MG
Seethamraju
H
H
Mahoney
D H
DH
McKenzie
E D
ED
Mallory
G B
GB
D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics* / Q000601:surgery / Q000628:therapy*; D017984:Enoxaparin / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D016040:Lung Transplantation / Q000379:methods*; D001523:Mental Disorders / Q000150:complications; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D012306:Risk; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics
D017984:Enoxaparin; D011516:Prothrombin; D006493:Heparin