[Heridity of non-syndromal orofacial clefts].
Non-syndromal orofacial clefts are congenital anomalies with a high incidence of heterogeneous origin. The condition is usually multifactorially determined, caused by interaction between multiple genetic and environmental factors. So far, only a few causal factors have been identified. Even in genetically identical individuals like monozygotic twins, the orofacial cleft is usually not fully concordant. As an illustration of non-syndromal orofacial clefts, monozygotic twin brothers with orofacial clefts which are not fully concordant are presented.
Van Esch
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Centrum voor Menselijke Erfelijkheid van het Universitair Ziekenhuis Leuven in België. hilde.vanesch@uz.kuleuven.ac.be
Verdonck
A
A
Carels
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CE
D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000209:etiology / Q000235:genetics*; D002972:Cleft Palate / Q000209:etiology / Q000235:genetics*; D004200:Diseases in Twins; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D014430:Twins, Monozygotic