Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.
A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities.
Periyasami
Govindasami
G
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
Raghunathan
Raghavachary
R
Surendiran
Gangadharan
G
Mathivanan
Narayanasamy
N
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001388:Aziridines / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects*; D002227:Carbazoles; D003500:Cyclization; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D007510:Isatin / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010944:Plants / Q000187:drug effects* / Q000382:microbiology; D011392:Proline / Q000737:chemistry; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology*; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000737:chemistry
D000890:Anti-Infective Agents; D001388:Aziridines; D001391:Azo Compounds; D002227:Carbazoles; D011763:Pyrrolizidine Alkaloids; D013141:Spiro Compounds; D013882:Thiosemicarbazones; C512188:azomethine; D007510:Isatin; D011392:Proline