title: Generalized lymphedema in a sirolimus-treated renal transplant patient.
abstract: Generalized lymphedema is an extremely rare effect of sirolimus therapy in renal transplant recipients. We describe the development of this complication in a 56-yr-old woman, who was given an experimental protocol with cyclosporine, sirolimus, steroids, and basiliximab. Following the protocol, after one month, the patient was randomized to the "sirolimus only" group, while cyclosporine was completely suspended and the oral steroids were continued. Three months later, the patient was admitted for severe lymphedema of the lower limbs, with significant weight increase, massive ascites and dyspnea, but excellent renal function. A chest radiography and an ultrasound study of the heart showed a moderate pleural and pericardial effusion. An abdominal ultrasound scan showed two small lymphoceles next to the transplanted kidney, confirmed with a CT scan. After sirolimus discontinuation the generalized lymphedema started to improve and three months later all the symptoms had disappeared.
authors.affiliation: UOC Chirurgia dei Trapianti-Azienda Ospedaliera Universitaria Senese, Siena, Italy. collini@unisi.it
authors.forename: Carmine
authors.initials: C
authors.lastname: De Bartolomeis
authors.forename: Andrea
authors.initials: A
authors.lastname: Collini
authors.forename: Brigitta
authors.initials: B
authors.lastname: Rumberger
authors.forename: Roberto
authors.initials: R
authors.lastname: Barni
authors.forename: Giuliana
authors.initials: G
authors.lastname: Ruggieri
authors.forename: Marco
authors.initials: M
authors.lastname: Bernini
authors.forename: Mario
authors.initials: M
authors.lastname: Carmellini
mesh_terms: D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008209:Lymphedema / Q000209:etiology*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020123:Sirolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus