Catalytic asymmetric hydroxylation of oxindoles by molecular oxygen using a phase-transfer catalyst.
The highly enantioselective catalytic hydroxylation of 3-substituted oxindoles was achieved by using a phase-transfer catalyst with molecular oxygen as an oxidant. The product then was converted to an optically active compound 8, which was a synthetic precursor of alkaloid CPC-1.
Sano
Daisuke
D
School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
Nagata
Kazuhiro
K
Itoh
Takashi
T
D002384:Catalysis; D006900:Hydroxylation; D007211:Indoles / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*
D007211:Indoles; D010100:Oxygen