Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.
We investigated the antistaphylococcal activities of daptomycin, gentamicin, and rifampin against two Staphylococcus aureus strains and their stable small-colony variants, singly and in combination, in human monocyte-derived macrophages and in broth. Intracellularly, the three-drug combination and two-drug combinations with rifampin were most effective. Extracellularly, daptomycin, daptomycin plus gentamicin, gentamicin plus rifampin, and the three-drug combination had similar activities.
Baltch
Aldona L
AL
Infectious Disease Research Laboratory, Stratton VA Medical Center, Albany, NY 12208, USA. Aldona.Baltch@med.va.gov
Ritz
William J
WJ
Bopp
Lawrence H
LH
Michelsen
Phyllis
P
Smith
Raymond P
RP
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D017576:Daptomycin / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000821:virology; D008826:Microbial Sensitivity Tests; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000821:virology; D012293:Rifampin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D017576:Daptomycin; D012293:Rifampin