IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism.
Recently discovered peptide hormone hepcidin is the key regulator of systemic iron homeostasis. Iron metabolism is regulated in response to variations in hepcidin plasma levels. Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively. The early studies showed that hypoxia, iron concentration, and inflammation influence hepcidin levels, but the exact mechanism remained elusive. Very recently, different research groups discovered that IL-6, through the Jak/STAT-3 signaling pathway, is involved in regulation of hepcidin levels in response to inflammatory stimuli. In this review we present a general view of hepcidin biology, with emphasis on regulation in inflammatory conditions.
Stoian
Irina
I
Department of Biochemistry, "Carol Davila", Faculty of Medicine, University of Medicine and Pharmacy, Bucharest, Romania.
Manolescu
B
B
Atanasiu
V
V
Lupescu
Olivera
O
Buşu
Carmina
C
D023181:Antimicrobial Cationic Peptides / Q000378:metabolism / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000502:physiology*; D007501:Iron / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000502:physiology*
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D015850:Interleukin-6; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D007501:Iron