The soluble transforming growth factor-beta receptor: advantages and applications.
Transforming growth factor-beta (TGF-beta) is a cytokine that plays a pivotal role in growth, differentiation, development, immune response and wound healing. TGF-beta is upregulated following wound infliction and inflammation, and plays an important role in the production of extracellular matrix proteins that contribute to tissue repair. However, in some diseases, TGF-beta dysregulation can lead to tumor formation, organ fibrosis and the disruption of organ function. A number of molecules have been designed to counteract the effects of TGF-beta, including anti-TGF-beta monoclonal antibodies and various small molecules. Here we discuss the design, use and advantages of the highly specific TGF-beta binding molecule, the soluble human TGF-beta receptor (sTbetaR.Fc) as a TGF-beta sequestering agent.
Russo
Leileata M
LM
Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. leileata.russo@receptor.mgh.harvard.edu
Brown
Dennis
D
Lin
Herbert Y
HY
D000818:Animals; D000911:Antibodies, Monoclonal; D002454:Cell Differentiation / Q000276:immunology; D049109:Cell Proliferation; D005109:Extracellular Matrix / Q000276:immunology / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy / Q000639:trends*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000276:immunology*; D014945:Wound Healing / Q000276:immunology
D000911:Antibodies, Monoclonal; D017452:Receptors, IgG; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta