title: Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma interferon responses to M. vaccae cell wall skeleton.
abstract: Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.
authors.affiliation: Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Rodríguez-Güell
authors.forename: Gemma
authors.initials: G
authors.lastname: Agustí
authors.forename: Mercè
authors.initials: M
authors.lastname: Corominas
authors.forename: Pere-Joan
authors.initials: PJ
authors.lastname: Cardona
authors.forename: Marina
authors.initials: M
authors.lastname: Luquin
authors.forename: Esther
authors.initials: E
authors.lastname: Julián
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D017358:Cell Wall Skeleton / Q000008:administration & dosage* / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis*; D051379:Mice; D009161:Mycobacterium / Q000737:chemistry* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000628:therapy
chemical_list: D001428:Bacterial Vaccines; D017358:Cell Wall Skeleton; D007371:Interferon-gamma