title: Genomic analysis of closely related astroviruses.
abstract: To understand astrovirus biology, it is essential to understand factors associated with its evolution. The current study reports the genomic sequences of nine novel turkey astrovirus (TAstV) type 2-like clinical isolates. This represents, to our knowledge, the largest genomic-length data set available for any one astrovirus type. The comparison of these TAstV sequences suggests that the TAstV species contains multiple subtypes and that recombination events have occurred across the astrovirus genome. In addition, the analysis of the capsid gene demonstrated evidence for both site-specific positive selection and purifying selection.
authors.affiliation: Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Errol
authors.initials: E
authors.lastname: Strain
authors.forename: Laura A
authors.initials: LA
authors.lastname: Kelley
authors.forename: Stacey
authors.initials: S
authors.lastname: Schultz-Cherry
authors.forename: Spencer V
authors.initials: SV
authors.lastname: Muse
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Koci
mesh_terms: D000818:Animals; D019350:Astroviridae Infections / Q000821:virology; D052676:Avastrovirus / Q000235:genetics* / Q000302:isolation & purification; D016679:Genome, Viral; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014422:Turkeys; D014481:United States
chemical_list: D012367:RNA, Viral