title: Solubilisation of [60]fullerenes using block copolymers and evaluation of their photodynamic activities.
abstract: Unmodified [60]fullerenes (C60) were solubilised with high stability using various type of poly(ethylene glycol) (PEG) based block copolymer micelles. Block copolymer micelle-incorporated C60 fullerenes were studied in cultures for biological activities using human cervical cancer HeLa cells. As a result, the cationic block copolymer micelles delivered C60 into the cells depending on their surface densities and showed cytotoxicity under photoirradiation.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Shintani
authors.forename: Yuki
authors.initials: Y
authors.lastname: Doi
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Ogawa
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yogo
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Takeya
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002412:Cations; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008823:Micelles; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D002412:Cations; D037741:Fullerenes; D008823:Micelles; D017319:Photosensitizing Agents; D011108:Polymers; D011092:Polyethylene Glycols; C069837:fullerene C60