title: CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
abstract: Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position -160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of other CDH1 polymorphisms and it is unclear whether any associations may be different by GC anatomical sites or histological types. Thus, a case-control study (cases=245/controls=950) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted to assess the GC risk association of eight CDH1 gene polymorphisms. None of the CDH1 polymorphisms or haplotypes analysed were associated with GC risk and no differences of effect were observed by Helicobacter pylori infection status. However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies.
authors.affiliation: International Agency for Research on Cancer (IARC-WHO), Lyon, France. Jenab@iarc.fr
authors.forename: Mazda
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authors.lastname: Jenab
authors.forename: James D
authors.initials: JD
authors.lastname: McKay
authors.forename: Pietro
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authors.forename: Carine
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authors.lastname: Biessy
authors.forename: Stewart
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authors.forename: Gabriel Maria Capella
authors.initials: GM
authors.lastname: Munar
authors.forename: Núria
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authors.lastname: Sala
authors.forename: Salvador
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authors.forename: Anja
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authors.lastname: Tjonneland
authors.forename: Françoise
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authors.lastname: Clavel-Chapelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Rudolf
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authors.lastname: Kaaks
authors.forename: Jakob
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authors.lastname: Linseisen
authors.forename: Heiner
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authors.forename: Antonia
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authors.lastname: Georgila
authors.forename: Theodora
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authors.lastname: Psaltopoulou
authors.forename: Amalia
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authors.lastname: Mattiello
authors.forename: Paolo
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authors.lastname: Vineis
authors.forename: Valeria
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authors.lastname: Pala
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
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authors.lastname: Tumino
authors.forename: Mattijs E
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authors.lastname: Numans
authors.forename: Petra H M
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authors.lastname: Peeters
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authors.lastname: Bueno-de-Mesquita
authors.forename: Eiliv
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authors.lastname: Lund
authors.forename: Eva
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authors.lastname: Ardanaz
authors.forename: Maria-Jose
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Miren
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authors.lastname: Dorronsoro
authors.forename: Carmen Navarro
authors.initials: CN
authors.lastname: Sanchez
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Quirós
authors.forename: Göran
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authors.lastname: Hallmans
authors.forename: Roger
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authors.lastname: Stenling
authors.forename: Jonas
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authors.lastname: Manjer
authors.forename: Sara
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authors.lastname: Régner
authors.forename: Tim
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authors.lastname: Key
authors.forename: Sheila
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authors.lastname: Bingham
authors.forename: Kay-tee
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authors.lastname: Khaw
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Fátima
authors.initials: F
authors.lastname: Carneiro
authors.forename: Elio
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authors.lastname: Riboli
authors.forename: Carlos
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authors.lastname: Gonzalez
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D004812:Epidemiologic Methods; D005060:Europe; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects*; D013274:Stomach Neoplasms / Q000209:etiology*
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins