title: Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer.
abstract: We present a rare manifestation of a chronic mandibular wound with a traumatic diathesis. A 38-year-old male patient sought medical consultation because of painless swelling in the mandibular symphysis and mild paresthesia of the lower lip. He mentioned a history of physical trauma to the mandibular symphysis 12 months ago. The radiographic evaluation and CT scan showed gross destruction of bone leading to a well-defined radiolucent lesion without any sclerosing margins. The histological examination revealed numerous spindle-shaped fibroblasts arranged in a fascicular pattern and scattered multinucleated and mononuclear cells with bizarre nuclei throughout the lesion. Moderate nuclear pleomorphism was evident with few mitotic cells. The lesion was diagnosed as a malignant fibrous histiocytoma of storiform-pleomorphic type based on the previous descriptions. After surgical removal of the lesion and the adjacent tissues and reconstruction, the patient was referred to a radiotherapist for continuation of treatment. Despite this therapy, the lesion recurred after a year, and prior to the second operation, the patient died as a result of brain involvement.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Tabriz University of Medical Sciences, Iran.
authors.forename: Ali Hossein
authors.initials: AH
authors.lastname: Mesgarzadeh
authors.forename: Ramin Mostofi Zadeh
authors.initials: RM
authors.lastname: Farahani
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Treister
mesh_terms: D000058:Accidental Falls; D000328:Adult; D001706:Biopsy; D015984:Causality; D002471:Cell Transformation, Neoplastic; D002908:Chronic Disease; D017809:Fatal Outcome; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000150:complications*; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D019930:Mandibular Prosthesis Implantation; D009364:Neoplasm Recurrence, Local; D011862:Radiography, Panoramic; D018714:Radiotherapy, Adjuvant; D035583:Rare Diseases; D012883:Skin Ulcer / Q000150:complications*; D014057:Tomography, X-Ray Computed