Short-term depressive symptoms and 30-day prognosis of hospitalized patients with acute coronary syndromes; the Greek study of acute coronary syndromes (GREECS).
OBJECTIVE
We evaluated whether short-term depressive symptoms are associated with the 30-day prognosis of hospitalized patients presented with acute coronary syndromes (ACS).


METHODS
A sample of 6 hospitals located in Greek urban and rural regions was selected. From October 2003 to September 2004, we recorded the non-fatal admissions of ACS. Assessment of depressive symptoms, during past month, was based on the CES-D scale (Radloff S., 1977).


RESULTS
2172 patients were included in the study (1649, 76% were males). The mean CES-D score was 13.5+/-12 in male patients and 13.6+/-12 in females (p=0.89). Compared to patients with angina those who had non-Q-wave MI or Q-wave MI had higher CES-D score (12.3+/-11.6 vs. 15.3+/-12.8 vs. 13.2+/-11.9, p=0.001). The number of events during the first 30-day following discharge was 9.2% in males and 9.7% in females. Multivariable logistic regression analysis revealed that 1-unit increase in CES-D was associated with 10% higher odds (95% CI 1.09-1.12) of re-current events (death or re-hospitalization), after adjusting for various socio-demographic, lifestyle and clinical factors.


CONCLUSIONS
We revealed that short-term depressive symptoms are related to more severe disease and a worsen 30-day prognosis of patients hospitalized for ACS.
Pitsavos
Christos
C
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Panagiotakos
Demosthenes B
DB
Arapi
Sophia
S
Giannopoulos
George
G
Masoura
Constandina
C
Tsiamis
Eleftherios
E
Stefanadis
Christodoulos
C
D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000534:rehabilitation*; D000368:Aged; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006115:Greece; D006760:Hospitalization; D006801:Humans; D008297:Male; D011379:Prognosis; D013997:Time Factors