Quantitative somatic sensory testing and functional imaging of the response to painful stimuli before and after cingulotomy for obsessive-compulsive disorder (OCD).
The middle cingulate cortex (MCC) has been implicated in pain processing by studies of cingulotomy for chronic pain and imaging studies documenting increased MCC blood flow in response to acute pain. The only previous report of quantitative sensory testing following cingulotomy described increased intensity and unpleasantness ratings of painful hot and cold stimuli in a single patient with psychiatric disease. We now report a case in which perception of pain and temperature was assessed before and after cingulotomy for obsessive-compulsive disorder (OCD). Positron emission tomographic (PET) studies of the blood flow response to acute pain were carried out using a single subject design which allowed for statistical evaluation of postoperative blood flow changes in this case. Postoperatively, the patient demonstrated increased intensity and unpleasantness ratings of painful thermal waterbath stimuli. The PET studies demonstrated preoperative contact heat pain-evoked activation of the bilateral MCC/SMA (supplementary motor area) and the left (contralateral) fronto-parietal operculum. Postoperative pain-evoked activation was demonstrated in the right (ipsilateral) parasylvian cortex but not of the MCC/SMA. Prior studies of forebrain lesions, and of cortical synchrony during the application of painful stimuli suggest the presence of functional connectivity between components of the MCC/SMA and the fronto-parietal opercula. Therefore present results suggest that cingulate lesions disinhibit ipsilateral parasylvian cortex and so are independent evidence of functional connectivity between these cortical areas, the defining characteristic of modules in a pain network.
Greenspan
Joel D
JD
Department of Biomedical Sciences, School of Dentistry, and Program in Neuroscience, University of Maryland, Baltimore, MD, USA.
Coghill
Robert C
RC
Gilron
Ian
I
Sarlani
Eleni
E
Veldhuijzen
Dieuwke S
DS
Lenz
Frederick A
FA
D000328:Adult; D000339:Affect; D001931:Brain Mapping; D003080:Cold Temperature / Q000009:adverse effects; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D006930:Hyperalgesia / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D038143:Inula / Q000033:anatomy & histology; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology / Q000503:physiopathology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000503:physiopathology / Q000601:surgery; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology / Q000601:surgery; D010146:Pain / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold; D049268:Positron-Emission Tomography; D011612:Psychosurgery / Q000009:adverse effects* / Q000379:methods; D013003:Somatosensory Cortex / Q000033:anatomy & histology; D013697:Thermosensing