[5-hydroxytryptamine and 5-methoxytryptamine increase tolerance to global cerebral ischemia].
In the global cerebral ischemia, 5-hydroxytryptamine (serotonin, 5-HT) and 5-methoxytryptamine (5-MT) produce a significant neuroprotector effect closely correlated with their hypothermic action. This expands the spectrum of cerebral functions controlled by 5-HT. At the same time, melatonin and 2-iodmelatonin, which are chemically (but not pharmacologically) close to 5-HT and 5-MT, do not exhibit such protective effects. Probably, an important role in the interaction with 5-HT receptors belongs to the NH2 group of the indole ring.
Gavrilov
S S
SS
Kulinskiĭ
V I
VI
D008735:5-Methoxytryptamine / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D008550:Melatonin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D012701:Serotonin / Q000737:chemistry / Q000494:pharmacology*; D018490:Serotonin Agents / Q000737:chemistry / Q000494:pharmacology*
D018696:Neuroprotective Agents; D018490:Serotonin Agents; D012701:Serotonin; D008735:5-Methoxytryptamine; C044556:2-iodomelatonin; D008550:Melatonin