Liver regeneration in living-related donors after harvesting of liver segments II and III or II, III and IV.
BACKGROUND
CT-assisted volumetry permits an estimation of the volume of the graft in liver transplantation, as well as monitoring the donor's liver regeneration. The aim of the study was to observe the restitution of liver tissue in donors after harvesting of the liver fragment for living-related liver transplantation (LRLT).


METHODS
The size of the whole liver and of segments II, III and IV was assessed by preoperative CT volumetry in 29 living-related liver donors. Segments II and III were harvested in 22 patients, segments II, III and IV in 6 patients. The remnant liver was assessed by CT volumetry on the 7th and 30th postoperative days.


RESULTS
The correlation between the calculated volume of the graft and its weight was linear (r=0.56, p<0.04). Postoperative CT volumetry of the liver of living-related donors showed a different pattern of volume restoration (regeneration index) at both 7 and 30 days between donors who sacrificed segments II and III and those who sacrificed segments II, III and IV. The mean regeneration indexes were significantly higher in donors of segments II, III and IV as compared with donors of segments II and III (7 days, p<0.02; 30 days, p<0.05).


CONCLUSIONS
It is possible that the donor's liver displays a different pattern of growth due to the alteration in blood supply to segment IV.
Krawczyk
M
M
Department of General and Liver Surgery, Medical University of Warsaw, Poland. hepaclin@waw.pdi.net
Paluszkiewicz
R
R
Pacho
R
R
Hevelke
P
P
Zieniewicz
K
K
Grzelak
I
I
Najnigier
B
B
Kosiński
C
C
Paczkowska
A
A
Michalak
M
M
Leowska
E
E
Kaliciński
P
P
Kamiński
A
A
Pawłowska
J
J