title: "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.
abstract: A key cell type of the resident skin immune system is the dendritic cell (DC), which in normal skin is located in two distinct microanatomical compartments: Langerhans cells (LCs), mainly in the epidermis, and dermal DCs (DDCs), in the dermis. Here, the lineage of DDCs was investigated using monoclonal antibodies and immunohistology. We provide evidence that "DDC" comprise at least two major phenotypic populations of dendritic-appearing cells, immature DC expressing CD1, CD11c and CD208; and macrophages expressing CD209, CD206, CD163, and CD68. These data suggest that dermal dendritic-appearing macrophages comprise a novel part of the innate immune response in the resident skin immune system.
authors.affiliation: Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Ochoa
authors.forename: Anya
authors.initials: A
authors.lastname: Loncaric
authors.forename: Stephan R
authors.initials: SR
authors.lastname: Krutzik
authors.forename: Todd C
authors.initials: TC
authors.lastname: Becker
authors.forename: Robert L
authors.initials: RL
authors.lastname: Modlin
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D018949:Antigens, CD1 / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D039521:CD11c Antigen / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000166:cytology* / Q000276:immunology*; D037181:Lectins, C-Type / Q000378:metabolism*; D008264:Macrophages / Q000166:cytology* / Q000276:immunology*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D018613:Microscopy, Confocal; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012867:Skin / Q000276:immunology / Q000473:pathology; D000098902:CD163 Antigen; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic; D039521:CD11c Antigen; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D000098902:CD163 Antigen; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C067980:CD68 antigen, human; D000097382:CD68 Molecule