Host defense peptides and the new line of defence against multiresistant infections.
Increasing antibiotic resistance has led to an urgent need for new therapeutic approaches. Host defense peptides are known to be antimicrobial and have revealed broad immunomodulatory functions for both innate and adaptive immunity. This review will focus on the role of host defense peptides in infection and immune response and discuss its potential and limitations as a future therapeutical agent.
Hirsch
Tobias
T
Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany.
Jacobsen
Frank
F
Steinau
Hans-Ulrich
HU
Steinstraesser
Lars
L
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D007113:Immunity, Innate
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides