sSgo1, a guardian of centriole cohesion.
Sgo1 plays a key role in protecting sister chromatid cohesion during mitosis. In this issue of Developmental Cell, Wang et al. describe a shorter splice variant of Sgo1 (sSgo1) that functions specifically in centriole cohesion. sSgo1 may be the "glue" that holds paired centrioles together in an engaged state before their disengagement in late mitosis.
Tsang
William Y
WY
Department of Pathology and Cancer Institute, New York University School of Medicine, 522 1(st) Avenue, New York, NY 10016, USA.
Dynlacht
Brian David
BD
D000268:Adhesiveness; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002502:Centrioles / Q000502:physiology*; D002842:Chromatids / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009687:Nuclear Proteins / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D000097722:Cohesins; C496644:SGO1 protein, human