title: Is elevated serum ceruloplasmin level associated with increased risk of coronary artery disease?
abstract: BACKGROUND
  An imbalance between the lipid peroxidation process and antioxidative protection is associated with the pathophysiology of coronary artery disease (CAD). The authors aimed to determine the relationship between the contributors of antioxidant protection, such as paraoxonase-1 (PON1) activity, albumin, vitamin C and ceruloplasmin (CP) levels, and lipid peroxidation indicators.
  
  
  METHODS
  In the present study, the activity of PON1 was measured, together with serum concentrations of a variety of lipid constituents, albumin, vitamin C and CP levels, and lipid peroxidation indicators (conjugated dienes [CDs] and thiobarbituric acid-reactive substances [TBARS]). Data were gathered from 26 nondiabetic, angiographically proven, Turkish CAD patients and 26 healthy controls living in the Antalya region (Turkey).
  
  
  RESULTS
  CAD patients had significantly lower PON1 activity, high-density lipoprotein cholesterol, vitamin C and albumin concentrations, and higher CP, CD and TBARS concentrations than the controls. In the entire study population (n=52), serum CP levels were positively correlated with TBARS and CD levels, and negatively correlated with albumin and vitamin C levels, as well as with PON1 activity. On multiple logistic regression analysis, risk factors associated with CAD included high CP and low albumin levels.
  
  
  CONCLUSIONS
  CAD patients and controls were matched for age and sex, and high CP and low albumin levels were found to be independent risk factors for CAD. The present data gathered from the study group living in the Antalya region verifies that in CAD patients, CP impairs the oxidant-antioxidant balance in favour of the oxidants.
authors.affiliation: Department of Biochemistry, Akdeniz University, Antalya, Turkey.
authors.forename: Ayşe Yeşim
authors.initials: AY
authors.lastname: Göçmen
authors.forename: Emel
authors.initials: E
authors.lastname: Sahin
authors.forename: Ender
authors.initials: E
authors.lastname: Semiz
authors.forename: Saadet
authors.initials: S
authors.lastname: Gümuşlü
mesh_terms: D000418:Albumins / Q000032:analysis; D043303:Aryldialkylphosphatase / Q000097:blood*; D001205:Ascorbic Acid / Q000097:blood; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014421:Turkey
chemical_list: D000418:Albumins; D008075:Lipoproteins, HDL; D002570:Ceruloplasmin; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D001205:Ascorbic Acid