Shortening of cardiac action potential duration near an insulating boundary.
It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre. An asymptotic approximation for the dependence of action potential duration on distance to the boundary is derived. This estimate agrees well with simulations.
Cain
John W
JW
Department of Mathematics and Center for Study of Biological Complexity, 1001 West Main Street, Virginia Commonwealth University, Richmond, VA 23284-2014, USA.
Schaeffer
David G
DG
D000200:Action Potentials; D000818:Animals; D001001:Anura; D003198:Computer Simulation; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction