The use of vasodilators in the treatment of acute decompensated heart failure: novel versus conventional therapy.
The majority of patients who present with acute decompensated heart failure require the addition of vasodilators to adequately reduce filling pressures and improve symptoms. Conventional therapies such as nitroglycerin and nitroprusside, although relatively effective, are difficult to use. Nesiritide, a natriuretic peptide and neurohormonal antagonist with potent vasodilator properties, may be a reasonable alternative. It offers several benefits in safety and convenience over conventional vasodilators, making it particularly suitable for both emergency department and inpatient use.
Kirk
J Douglas
JD
Department of Emergency Medicine, University of California, Davis, School of Medicine, Sacramento, CA, USA. jdkirk@ucdavis.edu
Diercks
Deborah B
DB
Amsterdam
Ezra A
EA