title: Chordoid meningioma: presentation of two case reports, review of the literature, and plea for data standardisation.
abstract: Chordoid meningioma is a rare variant of meningioma with histological features resembling those of chordoma. This tumour should have a greater risk of recurrence and aggressive growth (WHO grade II). So far, 92 such tumours have been described in the literature. We report two cases of chordoid meningioma occurring in adult female patients. In our two patients (aged 28 and 60 years with chordoid meningioma of the convexity and left-sided outer sphenoid wing, respectively) we centred on some rarely discussed aspects of the tumour. MRI scans showed no edema in the vicinity of either of the two meningiomas, whereas selective angiography of ACI and ACE revealed a dural type of vascular supply to the two neoplasms. In both cases, the tumour was removed by radical surgery (Simpson grade I resection) with a normal post-operative course. Both women (one 2 years post-surgery and one 4 years post-surgery) are now free from any signs of relapse on MRI and with normal neurological findings. The vascular endothelial growth factor (VEGF) expression was low in either case (5 and 40%, respectively). We regard the factors under consideration in our study (i.e. absence of edema, dural supply, low VEGF expression and radical Simpson grade I resection) as an important contribution to the discussion of the biological behaviour of chordoid meningioma.
authors.affiliation: Department of Neurosurgery, 1st Medical School, Charles University, Central Military Hospital, U vojenske nemocnice 1200, Prague 6, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Kozler
authors.forename: V
authors.initials: V
authors.lastname: Benes
authors.forename: D
authors.initials: D
authors.lastname: Netuka
authors.forename: F
authors.initials: F
authors.lastname: Kramár
authors.forename: P
authors.initials: P
authors.lastname: Hrabal
authors.forename: F
authors.initials: F
authors.lastname: Charvát
mesh_terms: D000328:Adult; D001706:Biopsy; D002560:Cerebrovascular Circulation; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D019635:Neurosurgical Procedures; D014746:Vimentin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin