title: Subendocardial viability ratio estimated by arterial tonometry: a critical evaluation in elderly hypertensive patients with increased aortic stiffness.
abstract: 1. Increased aortic stiffness predisposes to myocardial ischaemia by increasing the systolic tension-time index and by decreasing aortic pressure throughout diastole. The tonometric subendocardial viability ratio (SEVR) is a non-invasive estimate of myocardial perfusion relative to cardiac workload. The hypothesis that SEVR is impaired in elderly hypertensives with high aortic pulse pressure (PP) was tested in the present study. 2. The SEVR was calculated by radial applanation tonometry in 203 subjects. In addition, diastolic time (DT), systolic time (ST) and mean diastolic and systolic aortic pressures (Pd and Ps, respectively) were calculated. First, 60 subjects matched for age and gender were analysed (20 controls, 20 hypertensives with pulse pressure (PP) < or = 60 mmHg, 20 hypertensives with PP > 60 mmHg; mean (+/-SD) age 64 +/- 9 years; 24 women, 36 men). The remaining 143 subjects, aged 53 +/- 10 years, were analysed subsequently. 3. The SEVR was similar in the three elderly groups (1.39 +/- 0.34, 1.39 +/- 0.28 and 1.35 +/- 0.25, in controls and hypertensive patients with PP < or = 60 and > 60 mmHg, respectively). The SEVR was positively related to DT/ST (r(2) = 0.89) and to DT (r(2) = 0.73) and was negatively related to heart rate (r(2) = 0.56; P < 0.001 each). However, SEVR was not related to ST, PP, mean Pd or mean Ps. At a given DT/ST, SEVR tended to be lower in hypertensives with PP > 60 mmHg than in hypertensives with normal PP. The positive linear relationship between SEVR and DT/ST was confirmed in the remaining 143 subjects (r(2) = 0.90), with no influence of aortic pressure. 4. The tonometric SEVR was not impaired in elderly hypertensive patients with increased aortic stiffness. In resting elderly and middle-aged individuals, the tonometric SEVR was mainly related to DT/ST ratio, not to aortic pressure.
authors.affiliation: Paris-Sud University, Research Team EA4046, Le Kremlin-Bicêtre, France. denis.chemla@bct.aphp.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Chemla
authors.forename: Alain
authors.initials: A
authors.lastname: Nitenberg
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Teboul
authors.forename: Christian
authors.initials: C
authors.lastname: Richard
authors.forename: Xavier
authors.initials: X
authors.lastname: Monnet
authors.forename: Hervé
authors.initials: H
authors.lastname: le Clesiau
authors.forename: Paul
authors.initials: P
authors.lastname: Valensi
authors.forename: Mabrouk
authors.initials: M
authors.lastname: Brahimi
mesh_terms: D000368:Aged; D001011:Aorta / Q000473:pathology*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D008365:Manometry / Q000379:methods*; D008875:Middle Aged; D011673:Pulsatile Flow; D013599:Systole; D014655:Vascular Resistance / Q000502:physiology*