Synaptic asymmetry to go.
Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-associated molecule (Crtam).
Dustin
Michael L
ML
Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA. dustin@saturn.med.nyu.edu
D000818:Animals; D002455:Cell Division; D016764:Cell Polarity; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D007136:Immunoglobulins; C408522:class-I restricted T cell-associated molecule