Crystal structure of single-domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals.
Park
Suk-Youl
SY
Department of Chemistry and Institute of Basic Sciences, Chonnam National University, Gwangju 500-757, Korea.
Lee
Woo-Ram
WR
Lee
Suk-Chan
SC
Kwon
Myung-Hee
MH
Kim
Yong-Sung
YS
Kim
Jeong-Sun
JS
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000974:Antibodies, Antinuclear / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D001665:Binding Sites; D002104:Cadmium / Q000737:chemistry / Q000378:metabolism; D003035:Cobalt / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D006868:Hydrolysis; D007128:Immunoglobulin Fragments / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019216:Metals, Heavy / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D017422:Sequence Analysis, DNA; D014169:Transformation, Bacterial; D014325:Tromethamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D014867:Water / Q000737:chemistry
D000974:Antibodies, Antinuclear; D007128:Immunoglobulin Fragments; D019216:Metals, Heavy; D011994:Recombinant Proteins; C055966:immunoglobulin Fv; D002104:Cadmium; D014325:Tromethamine; D014867:Water; D003035:Cobalt; D004247:DNA; C026272:Bistris