CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.
The therapeutic imperative for Alzheimer disease (AD) and Parkinson disease (PD) calls for discovery and validation of biomarkers. Increased cerebrospinal fluid (CSF) tau and decreased amyloid (A) beta42 have been validated as biomarkers of AD. In contrast, there is no validated CSF biomarker for PD. We validated our proteomics-discovered multianalyte profile (MAP) in CSF from 95 control subjects, 48 patients with probable AD, and 40 patients with probable PD. An optimal 8-member MAP agreed with expert diagnosis for 90 control subjects (95%), 36 patients with probable AD (75%), and 38 patients with probable PD (95%). This MAP consisted of the following (in decreasing order of contribution): tau, brain-derived neurotrophic factor, interleukin 8, Abeta42, beta2-microglobulin, vitamin D binding protein, apolipoprotein (apo) AII, and apoE. This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD.
Zhang
Jing
J
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
Sokal
Izabela
I
Peskind
Elaine R
ER
Quinn
Joseph F
JF
Jankovic
Joseph
J
Kenney
Christopher
C
Chung
Kathryn A
KA
Millard
Steven P
SP
Nutt
John G
JG
Montine
Thomas J
TJ
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides; D001053:Apolipoproteins / Q000134:cerebrospinal fluid; D001057:Apolipoproteins E / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D010446:Peptide Fragments; D011498:Protein Precursors / Q000134:cerebrospinal fluid; D014809:Vitamin D-Binding Protein / Q000134:cerebrospinal fluid; D001613:beta 2-Microglobulin; D016875:tau Proteins / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D001053:Apolipoproteins; D001057:Apolipoproteins E; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016209:Interleukin-8; D010446:Peptide Fragments; D011498:Protein Precursors; D014809:Vitamin D-Binding Protein; C075222:amyloid beta-protein (1-42); C054949:apolipoprotein II; D001613:beta 2-Microglobulin; D016875:tau Proteins