title: Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats.
abstract: In the human brain, auditory sensory memory has been extensively studied using a well-defined component of event-related potential named the mismatch negativity (MMN). The MMN is generated in the auditory and frontal cortices in response to deviant stimuli. In monkeys, cortical N-methyl-d-aspartate (NMDA) receptors have a central role in the generation of the MMN. MMN-like responses have also been recorded in other animals, including rats. The present study aimed at determining whether the MMN-like response in rats depends on an intact NMDA-receptor system. We recorded auditory evoked responses during an oddball paradigm epidurally in anesthetized rats that had received intraperitoneal injections of saline or an NMDA-receptor antagonist MK-801. An MMN-like response was recorded in the oddball paradigm in saline-treated rats. Further, this response was dose-dependently blocked by MK-801. These results suggest that the MMN-like response in rats depends on an intact NMDA-receptor system.
authors.affiliation: Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Finland; Helsinki Brain Research Center, Finland.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Tikhonravov
authors.forename: Tuomas
authors.initials: T
authors.lastname: Neuvonen
authors.forename: Antti
authors.initials: A
authors.lastname: Pertovaara
authors.forename: Kati
authors.initials: K
authors.lastname: Savioja
authors.forename: Timo
authors.initials: T
authors.lastname: Ruusuvirta
authors.forename: Risto
authors.initials: R
authors.lastname: Näätänen
authors.forename: Synnöve
authors.initials: S
authors.lastname: Carlson
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D000758:Anesthesia; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects* / Q000502:physiology; D003265:Contingent Negative Variation / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
chemical_list: D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate