title: Drug delivery from the oral cavity: focus on a novel mechatronic delivery device.
abstract: Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery.
authors.affiliation: Fraunhofer-Institut Biomedizinische Technik, St. Ingbert, Germany. oliver.scholz@ibmt.fraunhofer.de
authors.forename: Oliver A
authors.initials: OA
authors.lastname: Scholz
authors.forename: Andy
authors.initials: A
authors.lastname: Wolff
authors.forename: Axel
authors.initials: A
authors.lastname: Schumacher
authors.forename: Libero I
authors.initials: LI
authors.lastname: Giannola
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Campisi
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ciach
authors.forename: Thomas
authors.initials: T
authors.lastname: Velten
mesh_terms: D000278:Administration, Buccal; D000284:Administration, Oral; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004343:Drug Implants / Q000008:administration & dosage; D004360:Drug Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism / Q000502:physiology*
chemical_list: D004343:Drug Implants