title: Rapid overgrowth of a fetus after interruption of insulin therapy in a diabetic woman.
abstract: We experienced a case of fetal overgrowth probably due to maternal hyperglycemia following the interruption of insulin therapy in a woman with gestational diabetes mellitus (GDM), probably undiagnosed type 2 diabetes mellitus. A 27-year-old Japanese woman was referred to our center because of GDM at 15 weeks of gestation. During the course of her educational admission, diet control and insulin therapy resulted in favorable blood sugar levels and she was discharged at 17 weeks of gestation. During these periods, fetal growth remained below average at between -1 and -1.5 S.D. After a check-up in the 29th week, she failed to appear for any further appointments. After the onset of labor, at 38 weeks of gestation, she suddenly consulted her former physician who delivered a baby weighing 4852g by cesarean section on the 38th week. A noteworthy point in this case is the growth curve of the fetus. Even if rapid overgrowth is assumed, starting after the time of interruption of insulin at 30 weeks of gestation, fetal weight gain appears to be about 400g per week, suggesting a weight increase at twice the normal rate. This case prompted us to keep in mind that rigid glycemic control will prevent the development of fetal macrosomia in diabetic pregnant women.
authors.affiliation: Department of Reproductive Biology Science and Perinatal Medicine, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Japan. tak-s@clin.medic.mie-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Nao
authors.initials: N
authors.lastname: Murabayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Umekawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagao
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kamimoto
authors.forename: Taku
authors.initials: T
authors.lastname: Sugihara
authors.forename: Norimasa
authors.initials: N
authors.lastname: Sagawa
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005320:Fetal Macrosomia / Q000175:diagnosis* / Q000209:etiology; D005865:Gestational Age; D006029:Glycosuria; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin