title: Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents.
abstract: BACKGROUND
  Diffusion tensor imaging (DTI) has revealed microstructural aspects of adolescent brain development, the cognitive correlates of which remain relatively uncharacterized.
  
  
  METHODS
  DTI was used to assess white matter microstructure in 18 typically developing adolescents (ages 16-18). Fractional anisotropy (FA) and mean diffusion (MD) were evaluated within the splenium and body of the corpus callosum in relation to cognitive performance.
  
  
  RESULTS
  Visuospatial construction abilities were associated with white matter integrity in both the splenium and body of the corpus callosum, while only splenium integrity was associated with language and psychomotor function.
  
  
  CONCLUSIONS
  Results suggest that, for typically developing adolescents, white matter coherence positively relates to visuospatial, psychomotor, and language skills. These findings may have implications for the cognitive functioning of clinical populations in which typical white matter development is altered.
authors.affiliation: San Diego State University/University of California-San Diego, Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, San Diego, CA 92120, USA.
authors.forename: Susanna L
authors.initials: SL
authors.lastname: Fryer
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Frank
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Spadoni
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Theilmann
authors.forename: Bonnie J
authors.initials: BJ
authors.lastname: Nagel
authors.forename: Alecia D
authors.initials: AD
authors.lastname: Schweinsburg
authors.forename: Susan F
authors.initials: SF
authors.lastname: Tapert
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D001076:Aptitude / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003337:Corpus Callosum / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology; D009483:Neuropsychological Tests; D012016:Reference Values