title: Retrospective audit of outcome of regional anesthesia for delivery in women with thrombocytopenia.
abstract: Regional anesthesia for pain at delivery in the presence of maternal thrombocytopenia is a clinical dilemma. We reviewed 10,369 obstetric cases (12 months) from our tertiary center. Generally, hemodilution of pregnancy does not result in thrombocyte counts of <150,000/mm(3) at delivery. A total of 166 births (1.6%) were recorded in women with thrombocytes <150,000/mm(3) at delivery. Parturients with >150,000/mm(3) at week 36 were separated post hoc (n=35; 21%) and the remaining parturients were divided as having <100,000/mm(3) (n=30; 18%) or 101,000-150,000/mm(3) (n=101; 60.5%). Epidural or spinal anesthesia was administered to 30% women with <100,000/mm(3) whereas 56% women with >101,000/mm(3) received these options (P=0.003). A total of 13.9% of parturients with trimester-long thrombocytopenia required blood products; 10/23 (43.5%) parturients undergoing cesarean section also required blood products (P=0.000). Four of six babies with Apgar scores of <or=7 at 1-min were born to women with platelets <100,000/mm(3) (P=0.009). There were no statistically significant differences in mean birth weights. Women with thrombocytes <150,000/mm(3) at birth but within the normal range at week 36 were more likely multiparas (P=0.001). We conclude that a difference in maternal and neonatal outcomes exists between mothers who were thrombocytopenic only at delivery compared to those with trimester-long thrombocytopenia, with the latter mothers and babies having more adverse events.
authors.affiliation: Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: Kyra
authors.initials: K
authors.lastname: Bernstein
authors.forename: Abigail
authors.initials: A
authors.lastname: Baer
authors.forename: Martine
authors.initials: M
authors.lastname: Pollack
authors.forename: Dov
authors.initials: D
authors.lastname: Sebrow
authors.forename: Deborah
authors.initials: D
authors.lastname: Elstein
authors.forename: Alexander
authors.initials: A
authors.lastname: Ioscovich
mesh_terms: D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D008485:Medical Audit; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000150:complications*