title: Human vesicular glutamate transporters functionally complement EAT-4 in C. elegans.
abstract: The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
authors.affiliation: IBST/Graduate Program in Neuroscience, Inje University, Busan 614-735, Korea.
authors.forename: Dukgyu
authors.initials: D
authors.lastname: Lee
authors.forename: Sunki
authors.initials: S
authors.lastname: Jung
authors.forename: Jungmin
authors.initials: J
authors.lastname: Ryu
authors.forename: Joohong
authors.initials: J
authors.lastname: Ahnn
authors.forename: Ilho
authors.initials: I
authors.lastname: Ha
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000166:cytology / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D050496:Vesicular Glutamate Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; C500224:Eat-4 protein, C elegans; D020033:Protein Isoforms; D017470:Receptors, Glutamate; D011993:Recombinant Fusion Proteins; D050496:Vesicular Glutamate Transport Proteins