title: Interplay between TRP channels and the cytoskeleton in health and disease.
abstract: Transient receptor potential (TRP) channels are a family of cation channels that play a key role in ion homeostasis and cell volume regulation. In addition, TRP channels are considered universal integrators of sensory information required for taste, vision, hearing, touch, temperature, and the detection of mechanical force. Seminal investigations exploring the molecular mechanisms of phototransduction in Drosophila have demonstrated that TRP channels operate within macromolecular complexes closely associated with the cytoskeleton. More recent evidence shows that mammalian TRP channels similarly connect to the cytoskeleton to affect cytoskeletal organization and cell adhesion via ion-transport-dependent and -independent mechanisms. In this review, we discuss new insights into the interplay between TRP channels and the cytoskeleton and provide recent examples of such interactions in different physiological systems.
authors.affiliation: University of Dundee, MRC Protein Phosphorylation Unit, Dundee DD1 5EH, Scotland, UK.
authors.forename: Kristopher
authors.initials: K
authors.lastname: Clark
authors.forename: Jeroen
authors.initials: J
authors.lastname: Middelbeek
authors.forename: Frank N
authors.initials: FN
authors.lastname: van Leeuwen
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D029721:Drosophila Proteins / Q000502:physiology; D004331:Drosophila melanogaster / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000209:etiology; D008954:Models, Biological; D050051:Transient Receptor Potential Channels / Q000378:metabolism*; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; D050051:Transient Receptor Potential Channels