title: Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration.
abstract: OBJECTIVE
  The aim of this study was to investigate changes in excitability properties associated with axonal regeneration in human neuropathy and a mouse Wallerian degeneration model.
  
  
  METHODS
  Threshold tracking was used to measure axonal excitability indices such as strength-duration time constant (SDTC), threshold electrotonus, supernormality in median motor axons at the wrist of 13 patients with vasculitic neuropathy in their recovery phase, and in tibial motor axons at the ankle of mice with sciatic nerve crush. In the mouse model, excitability testing was performed 4, 8, 12, and 20weeks after the nerve crush.
  
  
  RESULTS
  In patients, there were longer SDTC, greater threshold changes at 0.2ms in latent addition, and greater threshold changes in depolarizing and hyperpolarizing threshold electrotonus, compared with controls. The pattern of changes in excitability indices was similar to those in experimental nerve crush, in which the indices remained abnormal for 20weeks after the crush. These changes suggest an increase in nodal persistent sodium currents, whereas multiple factors may also contribute to changes in excitability properties, such as axonal hyperpolarization, increased internodal resistance, and altered potassium currents.
  
  
  CONCLUSIONS
  Excitability properties in regenerating axons are characterized by increased nodal persistent currents with variable combination of changes in passive properties, membrane potential, and potassium currents.
  
  
  CONCLUSIONS
  Increased persistent sodium currents are potential reasons for positive symptoms in patients with axonal neuropathy. Sodium channel blockers could be considered a treatment option.
authors.affiliation: Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. ssawai@yj8.so-net.ne.jp
authors.forename: Setsu
authors.initials: S
authors.lastname: Sawai
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kanai
authors.forename: Miho
authors.initials: M
authors.lastname: Nakata
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Hiraga
authors.forename: Sonoko
authors.initials: S
authors.lastname: Misawa
authors.forename: Sagiri
authors.initials: S
authors.lastname: Isose
authors.forename: Takamichi
authors.initials: T
authors.lastname: Hattori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D000368:Aged; D000818:Animals; D001369:Axons / Q000502:physiology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D009416:Nerve Regeneration / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D014855:Wallerian Degeneration / Q000503:physiopathology*