title: [Effect of GBV-C/HIV coinfection on HIV/AIDS disease progression and HIV replication].
abstract: Several research groups have recently reported that persistent GB virus C (GBV-C) co-infected with human immunodeficiency virus (HIV) leads to slower AIDSs disease progression than HIV-1 infection alone. However, these findings were not confirmed by several other studies. To investigate the association between GBV-C replication and plasma HIV loads and CD4+ T cell counts, 203 HIV-1 positive former blood/plasma donors(FBDs) were enrolled from Fuyang city of Anhui Province in China. Plasma specimens were collected from them and were tested for GBV-C using RT-PCR and ELISA. Out of 203 specimens, 52 (25.6%) cases were positive for GBV-C, including 35 male (67.3%) and 17 female (32.7%) cases. No significant association was identified between GBV-C infection and CD4+ T-cell counts or between GBV-C infection and HIV viral loads. Since all the subjects studied were naive to ART, the influence of therapy on AIDS disease progression was ruled out in this study. Overall, our data indicated that HIV-1 positive male FBDs were prone to be infected, GBV-C coinfection with HIV-1 does not significantly influence HIV/AIDS disease progression during the late stage of chronic HIV-1 infection.
authors.affiliation: National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhu
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Ding
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Wan
authors.forename: Lian-Xing
authors.initials: LX
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Peng
authors.forename: Xiang-Gang
authors.initials: XG
authors.lastname: Huang
authors.forename: Yan-Meng
authors.initials: YM
authors.lastname: Feng
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Ruan
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Su
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Xu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shao
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology / Q000821:virology*; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D018178:Flaviviridae Infections / Q000276:immunology / Q000821:virology*; D029407:GB virus C; D015497:HIV-1 / Q000502:physiology*; D006525:Hepatitis, Viral, Human / Q000276:immunology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D014779:Virus Replication
chemical_list: D012367:RNA, Viral