title: Novel class of hybrid natural products derived from lupeol as antimalarial agents.
abstract: Thirty-four novel hybrid lupeol derivatives (4-18) were prepared and evaluated for antimalarial activity in vitro against Plasmodium falciparum. Three compounds (13d, 16a and 17a) have shown antimalarial activity at lower dose (10 microg mL(-1)) than lupeol.
authors.affiliation: Division of Medicinal and Process Chemistry, India.
authors.forename: Satish
authors.initials: S
authors.lastname: Kumar
authors.forename: Namita
authors.initials: N
authors.lastname: Misra
authors.forename: Kanwal
authors.initials: K
authors.lastname: Raj
authors.forename: Kumkum
authors.initials: K
authors.lastname: Srivastava
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000737:chemistry*; D000094042:Lupanes
chemical_list: D000962:Antimalarials; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes