[Distribution and antifungal susceptibility of Candida clinical isolations coming from six health care centers in the metropolitan area of Caracas, Venezuela (years 2003-2005)].
The aim of this study was to investigate the frequency and antifungal susceptibility of Candida clinical isolations coming from patients with candidiasis in six health care centers of Caracas, Venezuela metropolitan area. The laboratory reports were retrospectively revised from January 2003 through August 2005. The isolated yeasts identification was carried out by conventional methods and antifungal susceptibility was evaluated by ATB-fungus (bioMérieux, France) and Etest (AB Biodisk, Solna, Sweden). One thousand nine hundred seventy seven (1.977) yeasts were studied and their susceptibility testing were carried out only in 1,414 of them. C. albicans was the most isolated yeast (46.7%) and none-albicans Candida-species represented more than half of the isolations (53.4%). All the isolated yeasts evaluated presented CMIs<1 microg/ml to anfotericina B and showed variable susceptibility percentages to fluconazole (91.5%), itraconazole (80%) and voriconazole (98.6%).
Dolande Franco
Maribel E
ME
Departamento de Micología, Instituto Nacional de Higiene Rafael Rangel, Ciudad Universitaria, Los Chaguaramos, Caracas, Venezuela. mdolande@inhrr.gov.ve
Reviákina
Vera
V
Panizo
María Mercedes
MM
Macero
Carolina
C
Moreno
Xiomara
X
Calvo
Alberto
A
Selgrad
Sofía
S
Papatzikos
Juana
J
Vergara
Vivian
V
Mendoza
María José
MJ
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001826:Body Fluids / Q000382:microbiology; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D009928:Organ Specificity; D012189:Retrospective Studies; D013045:Species Specificity; D014687:Venezuela / Q000453:epidemiology
D000935:Antifungal Agents