title: [Primary drug resistance in Mycobacterium tuberculosis among patients with pulmonary tuberculosis and its impact on permanent disability in the Volgograd region].
abstract: In the past 5 years, there has been a rise in the number of patients with new-onset drug-resistant pulmonary tuberculosis from 32.3% to 44.0%. The pattern of primary resistance is marked by an increase in the proportion of multidrug resistant Mycobacterium tuberculosis (MBT) strains, by the steady-state level of their isolation, and by a reduction in the detection rate of unidrug resistant strains. The efficiency of treatment in pulmonary tuberculosis patients with primary MBT resistance depends on patient compliance. After 3-year follow-up, death occurred in 12.2% of the patients, the tuberculous process became chronic in 31.7%, and there was a relapse in 9.8%. The drug resistance of the causative agent affects the duration of disability due to tuberculosis to a greater extent than does multidrug resistance.
authors.forename: A S
authors.initials: AS
authors.lastname: Borzenko
authors.forename: S G
authors.initials: SG
authors.lastname: gagarina
authors.forename: I V
authors.initials: IV
authors.lastname: Samoĭlova
authors.forename: A A
authors.initials: AA
authors.lastname: Kalushenina
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002391:Catchment Area, Health; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D015995:Prevalence; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents