[Endothelial changes in cardiovascular pathology in the elderly. Part 2. Signal molecules and the pathogenesis of atherosclerosis].
This article is a continuation of the review on the issue of the interaction between the endothelium and numerous biologically active substances, secreted by endotheliocytes and their environment--the so called signal molecules--in the most prevalent cardiovascular pathology in the elderly. For example tumor necrosis factor plays a pathogenetic role as an immunomodulator, possesses anti-inflammatory and pro-atherogenic properties, provokes endothelial dysfunction, and stimulates the expression of other pro-inflammatory cytokines. Other signal molecules are described as well. The article also presents data from studies directed towards the perfection of atherosclerosis therapy via affecting signal molecules: depression of the expression of interleukins and their receptors, inhibition of atherogenic interleukins, neutralization of pro-inflammatory interleukins, and introduction of interleukin receptor antagonists.
Proshchaev
K I
KI
Il'intski
A N
AN
Kvetnoĭ
I M
IM
Zeziulin
P N
PN
Kniaz'kin
I V
IV
Konovalov
S S
SS
Filippov
S V
SV
D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D014664:Vasodilation / Q000502:physiology*
D016207:Cytokines