title: Uveal vs. cutaneous melanoma. Origins and causes of the differences.
abstract: Melanoma is a malignant tumour derived from melanocytes (dendritic cells originated from the neural crest and capable to produce melanin synthesis) that could be established on the skin or less frequently on the uvea. The cellular origin from both kind of melanoma seems to be the same but the melanocytes migrates to the epithelia for cutaneous melanoma, while for uveal melanoma, they migrate to mesodermic tissues. Despite the common origin, both melanomas show extreme differences in their metastatic potential, clinical response to treatments, immune response and genetic alterations. We will describe some of those differences in this review.
authors.affiliation: Universidad Francisco de Vitoria, Facultad de Ciencias Biosanitarias, Dpto. Biotecnología, Pozuelo de Alarcón, Madrid, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Belmar-Lopez
authors.forename: Pablo
authors.initials: P
authors.lastname: Mancheno-Corvo
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Saornil
authors.forename: Patrick
authors.initials: P
authors.lastname: Baril
authors.forename: Georges
authors.initials: G
authors.lastname: Vassaux
authors.forename: Miguel
authors.initials: M
authors.lastname: Quintanilla
authors.forename: Pilar
authors.initials: P
authors.lastname: Martin-Duque
mesh_terms: D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D014604:Uveal Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*