title: Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice.
abstract: We evaluated tissue changes associated with cerium chloride administration via gavage to adult mice, via milk to neonatal mice and transplacentally to fetal mice. Change in adults consisted of extensive pulmonary hemorrhage, pulmonary venous congestion, thickened alveolar septae, hepatic necrosis and neutrophil infiltrations. Those in fetal mice consisted of pulmonary and hepatic congestion. These results indicate that gavage cerium administration elicited subtle tissue changes, though oral toxicity is rather low. These changes were less severe in neonatal and fetal mice. When cerium was injected into adult mice through the tail vein, cerium was distributed mainly to the liver, spleen and lung dose-dependently with the cerium concentration gradually decreasing after 3 days. A study of cerium anticoagulation in mouse plasma showed that clotting time was significantly prolonged when cerium was added to plasma. These results suggest that cerium may disturb blood coagulation and cause pulmonary and hepatic vascular congestion.
authors.affiliation: Department of Biochemistry, Akita University School of Medicine, Akita 010-8543, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Kawagoe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Shou-Cun
authors.initials: SC
authors.lastname: Wang
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Szilvia
authors.initials: S
authors.lastname: Arany
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhou
authors.forename: Jing-Shu
authors.initials: JS
authors.lastname: Wang
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Ueno
authors.forename: Yukio
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kameda
authors.forename: Souichi
authors.initials: S
authors.lastname: Koyota
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D002563:Cerium / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D000925:Anticoagulants; D002563:Cerium; C026690:cerous chloride