title: Molecularly imprinted polymer based potentiometric sensor for the determination of hydroxyzine in tablets and biological fluids.
abstract: Molecular imprinting is a useful technique for the preparation of functional materials with molecular recognition properties. In this work, a biomimetic potentiometric sensor, based on a non-covalent imprinted polymer, was fabricated for the recognition and determination of hydroxyzine in tablets and biological fluids. The molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization, using hydroxyzine dihydrochloride as a template molecule, methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylat (EGDMA) as a cross-linking agent. The sensor showed a high selectivity and a sensitive response to the template in aqueous system. The MIP-modified electrode exhibited a Nernstian response (29.4+/-1.0 mV decade(-1)) in a wide concentration range of 1.0x10(-6) to 1.0x10(-1) M with a lower detection limit of 7.0x10(-7) M. The electrode demonstrated a response time of approximately 15s, a high performance and a satisfactory long-term stability (more than 5 months). The method has the requisite accuracy, sensitivity and precision to assay hydroxyzine in tablets and biological fluids.
authors.affiliation: Department of Chemistry, Amirkabir University of Technology, Tehran, Iran. mehranjavanbakht@gmail.com
authors.forename: Mehran
authors.initials: M
authors.lastname: Javanbakht
authors.forename: Solmaz Eynollahi
authors.initials: SE
authors.lastname: Fard
authors.forename: Ali
authors.initials: A
authors.lastname: Mohammadi
authors.forename: Majid
authors.initials: M
authors.lastname: Abdouss
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ganjali
authors.forename: Parviz
authors.initials: P
authors.lastname: Norouzi
authors.forename: Leila
authors.initials: L
authors.lastname: Safaraliee
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D004566:Electrodes; D006801:Humans; D006919:Hydroxyzine / Q000032:analysis*; D011108:Polymers / Q000737:chemistry*; D011199:Potentiometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared; D013607:Tablets / Q000737:chemistry*
chemical_list: D011108:Polymers; D013607:Tablets; D006919:Hydroxyzine