title: The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.
abstract: BACKGROUND
  Concentrations of adiponectin, the protein product of the adipocyte C1q and collagen-domain-containing (ADIPOQ) gene are associated with type 2 diabetes and coronary artery disease. We investigate the association of single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene with adiponectin concentrations, and to parameters of metabolic syndrome.
  
  
  METHODS
  867 unrelated, non-diabetic Korean women, 20 to 69 y, were genotyped for 8 SNPs in the ADIPOQ gene (-11391G>A, -11377C>G, H241P, Y111H, G90S, R221S, 45T>G, 276G>T). Adiponectin, a homeostasis model assessment of insulin resistance (HOMA-IR), and metabolic parameters were measured.
  
  
  RESULTS
  Carriers of genotype T/T at position 276 had significantly higher adiponectin concentrations than G/G carriers (P=0.005). Homozygous carriers of the TG haplotype (i.e., individuals who were T/T at 45 and G/G at 276) and heterozygous carriers of the TG haplotype (TG/X) had lower adiponectin concentrations than non-TG carriers (P<0.001). Significant associations between SNP at 276 and serum concentrations of triglyceride (P=0.013), insulin (P=0.013) and HOMA-IR (P=0.012) were found. The 45-276 haplotypes had associations identical to the 276G>T SNP. In subgroup analysis, subjects carrying the TG haplotype had significantly lower adiponectin concentrations than non-TG carriers in both normal weight (P<0.001) and overweight-obese (P=0.009) subgroups. The association of the TG haplotype with increasing insulin concentrations was significant among overweight-obese subjects (P=0.004), but was not significant among normal weight subjects. A similar association was found between the 45-276 haplotype and HOMA-IR.
  
  
  CONCLUSIONS
  There is a strong association of the adiponectin SNP276 genotypes and the adiponectin 45-276 haplotypes with circulating adiponectin concentrations in non-diabetic Korean women. In addition, this haplotype is associated with increased insulin concentrations and insulin resistance index only in overweight-obese individuals.
authors.affiliation: Cardiovascular Genome Center, Cardiovascular Hospital, Severance Hospital, Seoul, Korea.
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Jey Sook
authors.initials: JS
authors.lastname: Chae
authors.forename: Soo Jeong
authors.initials: SJ
authors.lastname: Koh
authors.forename: Yae Jung
authors.initials: YJ
authors.lastname: Hyun
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Yeo Jin
authors.initials: YJ
authors.lastname: Jeong
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
authors.forename: Chul-Min
authors.initials: CM
authors.lastname: Ahn
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007328:Insulin / Q000097:blood; D007723:Korea / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D007328:Insulin; D014280:Triglycerides