Indirect allorecognition: not simple but effective.
Donor dendritic cells are potent but short-lived stimulators of early transplant rejection, and recipient antigen presenting cells presenting donor major histocompatibility complex peptides sustain immunoreactivity and contribute to chronic rejection. We briefly consider how CD4 T cells that recognize allopeptide can provide help for effector and regulatory responses and highlight the implications for promoting graft survival.
Bolton
Eleanor M
EM
NIHR Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. emb34@cam.ac.uk
Bradley
J Andrew
JA
Pettigrew
Gavin J
GJ
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008285:Major Histocompatibility Complex; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
D007519:Isoantigens; D011948:Receptors, Antigen, T-Cell