title: Isolated lymphadenitis due to Histoplasma capsulatum diagnosed by fine-needle aspiration biopsy and immunohistochemistry.
abstract: In the disseminated form of histoplasmosis, isolation and further identification of Histoplasma capsulatum can be performed by several methods, namely, bone marrow aspiration, blood culture, and liver biopsy. Lymph node disease usually is diagnosed by excisional biopsy. Although fungal stains can identify this fungus, detection of specific antigens by immunohistochemistry shows a higher specificity and sensitivity. This approach can use the cell block method when the material is not sent to fungal cultures or fresh staining.
authors.affiliation: Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil. flptuon@gmail.com
authors.forename: Felipe F
authors.initials: FF
authors.lastname: Tuon
authors.forename: Vivian
authors.initials: V
authors.lastname: Gomes
authors.forename: Carla
authors.initials: C
authors.lastname: Pagliari
authors.forename: Bruno B
authors.initials: BB
authors.lastname: Ctenas
authors.forename: Patrícia
authors.initials: P
authors.lastname: Carrasco Flores de Moscoso
authors.forename: René
authors.initials: R
authors.lastname: Gerhard
authors.forename: Luciane
authors.initials: L
authors.lastname: Kanashiro
authors.forename: Roosecelis A
authors.initials: RA
authors.lastname: Brasil
authors.forename: Maria Irma
authors.initials: MI
authors.lastname: Seixas Duarte
mesh_terms: D000946:Antigens, Fungal / Q000032:analysis; D044963:Biopsy, Fine-Needle; D006658:Histoplasma / Q000276:immunology; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008199:Lymphadenitis / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009333:Neck
chemical_list: D000946:Antigens, Fungal