MRI contrast media are used to improve visualization of abnormal structures or lesions in various parts of the body. Introduction.
Until recently it was believed that extracellular gadolinium based contrast agents (Gd-CA) were safe for both the kidneys and all other organs within the dose range up to 0.3mmol/kg body weight. However, in 2006, it was demonstrated that some Gd-CA may trig the development of nephrogenic systemic fibrosis, a generalized fibrotic disorder, in renal failure patients. This sub-section of European Journal of Radiology covers the current knowledge about NSF from many aspects. The prevention of NSF must be given high priority, but it should not lead to a denial of a well-justified, enhanced MRI examination with a stable agent.
Thomsen
Henrik S
HS
Department of Diagnostic Radiology, Copenhagen University Hospital, Herlev, Herlev Ringvej 75, DK-2730 Herlev, Denmark. hentho01@heh.regionh.dk
Marckmann
Peter
P
D003287:Contrast Media / Q000009:adverse effects* / Q000737:chemistry; D005355:Fibrosis / Q000139:chemically induced; D005682:Gadolinium / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007674:Kidney Diseases / Q000139:chemically induced*; D008279:Magnetic Resonance Imaging; D012871:Skin Diseases / Q000139:chemically induced*
D003287:Contrast Media; D005682:Gadolinium