Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin.
To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P105 (P105) and d-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle concentration (CMC) was used to evaluate the micellar stability towards dilution. Poorly soluble anticancer drug CPT was incorporated into the mixed micelles. The solubility of CPT by the mixed micelles was more than that of the free drug. The cytotoxicity of the CPT-loaded mixed micelles against MCF-7 cancer cell in vitro was remarkably higher than that of the free drug.
Gao
Yan
Y
Department of Pharmaceutics, School of Pharmacy, Shandong University, Jinan 250012, China.
Li
Ling Bing
LB
Zhai
Guangxi
G
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D002166:Camptothecin / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003124:Colorimetry; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D020442:Poloxamer / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D008823:Micelles; D020442:Poloxamer; D014810:Vitamin E; D011092:Polyethylene Glycols; C519610:pluronic P105; C014225:tocophersolan; D002166:Camptothecin