Hungry for blood vessels: linking metabolism and angiogenesis.
A new study by Arany et al. demonstrates that the metabolic master regulator peroxisome proliferator-activated receptor (PPARgamma) coactivator-1alpha (PGC-1alpha) can promote angiogenesis. These findings show that alterations in metabolic homeostasis are linked to angiogenesis, which raises exciting opportunities for novel proangiogenic and antiangiogenic therapies in various diseases.
Fraisl
Peter
P
Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B-3000, Belgium.
Baes
Myriam
M
Carmeliet
Peter
P
D000818:Animals; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D047495:PPAR gamma / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D047495:PPAR gamma; D015534:Trans-Activators; D042461:Vascular Endothelial Growth Factor A