title: [Detection of the primary tumor site in tumor-induced osteomalacia by indium-111 octreotide scintigraphy: a case report].
abstract: We report a 31-year-old woman with tumor-induced osteomalacia suffering from slowly progressive bilateral muscle weakness predominantly in the proximal muscles and multiple bone pains for the past 2 years. She was unable to walk or raise her arms above the shoulder. We suspected tumor-induced osteomalacia due to decreased serum phosphate and 1alpha, 25 (OH),-vitamin D3 levels, low percentage of tubular reabsorption of phosphate (%TRP), adult onset, and no family history of osteomalacia. Regular imaging examinations could not detect the location of the primary tumor: however, indium-111 octreotide scintigraphy detected the causative primary mesenchymal tumor in the right sole. Pain and muscle weakness improved promptly after tumor resection, and she was able to walk 6 d postoperatively. This is the first case report in Japan describing the detection of the primary tumor site by indium-111 octreotide scintigraphy.
authors.affiliation: Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University.
authors.forename: Makoto
authors.initials: M
authors.lastname: Takahashi
authors.forename: Syuta
authors.initials: S
authors.lastname: Toru
authors.forename: Kiyohumi
authors.initials: K
authors.lastname: Ota
authors.forename: Hajime
authors.initials: H
authors.lastname: Izumiyama
authors.forename: Takanori
authors.initials: T
authors.lastname: Yokota
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000328:Adult; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005528:Foot; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology; D007205:Indium Radioisotopes; D008637:Mesenchymoma / Q000150:complications* / Q000000981:diagnostic imaging* / Q000378:metabolism; D015282:Octreotide; D010018:Osteomalacia / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D015282:Octreotide