Complexation of L-lactate with boronic acids: a solution and holographic analysis.
Boronic acids have been used as receptors for the detection of diols and alpha-hydroxy acids. The incorporation of 3-acrylamide phenyl boronic acid (3-APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L-lactate. However, it was also found that the use of 3-APB resulted in the sensor being responsive towards a number of other compounds containing two hydroxy groups. This report details the further investigation into the reaction between L-lactate and three boronic acid-based receptors, both in the holograms and in solution, in order to establish the mechanism of binding. A novel boronate receptor is proposed based on this understanding.
Sartain
Felicity K
FK
Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK.
Yang
Xiaoping
X
Lowe
Christopher R
CR
D001897:Boronic Acids / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D006696:Holography; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions
D001897:Boronic Acids; D012996:Solutions; D019344:Lactic Acid; D005947:Glucose