title: Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica.
abstract: Three pyridinium inner salt alkaloids, lonijaposides A-C (1-3), based on an unprecedented skeleton of an N-substituted nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid, together with seven known iridoids, have been isolated from the flower buds of Lonicera japonica. Their structures were elucidated by spectroscopic and chemical analyses. Lonijaposide C (3) showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
authors.forename: Weixia
authors.initials: W
authors.lastname: Song
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Sujuan
authors.initials: S
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zi
authors.forename: Maoluo
authors.initials: M
authors.lastname: Gan
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mingtao
authors.initials: M
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D035264:Flowers / Q000737:chemistry; D005966:Glucuronidase / Q000187:drug effects / Q000378:metabolism; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031239:Lonicera / Q000737:chemistry*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
chemical_list: D039823:Iridoids; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; C530312:lonijaposide A; C530313:lonijaposide B; C530314:lonijaposide C; D005966:Glucuronidase