title: [Heridity of non-syndromal orofacial clefts].
abstract: Non-syndromal orofacial clefts are congenital anomalies with a high incidence of heterogeneous origin. The condition is usually multifactorially determined, caused by interaction between multiple genetic and environmental factors. So far, only a few causal factors have been identified. Even in genetically identical individuals like monozygotic twins, the orofacial cleft is usually not fully concordant. As an illustration of non-syndromal orofacial clefts, monozygotic twin brothers with orofacial clefts which are not fully concordant are presented.
authors.affiliation: Centrum voor Menselijke Erfelijkheid van het Universitair Ziekenhuis Leuven in België. hilde.vanesch@uz.kuleuven.ac.be
authors.forename: H
authors.initials: H
authors.lastname: Van Esch
authors.forename: A
authors.initials: A
authors.lastname: Verdonck
authors.forename: C E L
authors.initials: CE
authors.lastname: Carels
mesh_terms: D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000209:etiology / Q000235:genetics*; D002972:Cleft Palate / Q000209:etiology / Q000235:genetics*; D004200:Diseases in Twins; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D014430:Twins, Monozygotic