title: Paramyxoviruses: different receptors - different mechanisms of fusion.
abstract: Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.
authors.affiliation: Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. ronald.iorio@umassmed.edu
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Iorio
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mahon
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000235:genetics*; D015707:HN Protein / Q000737:chemistry / Q000378:metabolism; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008459:Measles virus / Q000378:metabolism / Q000472:pathogenicity*; D008561:Membrane Fusion; D009522:Newcastle disease virus / Q000378:metabolism / Q000472:pathogenicity*; D011991:Receptors, Virus / Q000737:chemistry / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D015707:HN Protein; D006389:Hemagglutinins, Viral; D011991:Receptors, Virus; D014764:Viral Proteins