title: [Case of acute eosinophilic pneumonia probably induced by minocycline].
abstract: We reported a case of acute eosinophilic pneumonia (AEP) induced by minocycline. A 55-year-old man presented with a low grade fever and cough and was treated with antibiotics, including minocycline (MINO). During treatment, the patient developed symptoms of acute respiratory failure, and computed tomography (CT) scan showed bilateral ground grass opacities. Bronchoalveolar lavage (BAL) was performed. The percentage of eosinophils in the BAL fluid was elevated (66%). The patient was treated with methylprednisolone under a diagnosis of AEP. Immediately after initiation of therapy, the CT film findings and clinical symptoms improved. Although a drug-induced lymphocyte stimulation test for MINO was negative, we speculated that AEP was caused by MINO in this case.
authors.affiliation: Department of Internal Medicine, Joetsu General Hospital.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Natsue
authors.initials: N
authors.lastname: Shimizu
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kinebuchi
authors.forename: Jozi
authors.initials: J
authors.lastname: Toyama
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D018893:Bronchoalveolar Lavage; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline; D008775:Methylprednisolone