Flattened cortical maps of cerebral function in the rat: a region-of-interest approach to data sampling, analysis and display.
We describe a method for the measurement, analysis and display of cerebral cortical data obtained from coronal brain sections of the adult rat. In this method, regions-of-interest (ROI) are selected in the cortical mantle in a semiautomated fashion using a radial grid overlay, spaced in 15 degrees intervals from the midline. ROI measurements of intensity are mapped on a flattened two-dimensional surface. Topographic maps of statistical significance at each ROI allow for the rapid viewing of group differences. Cortical z-scores are displayed with the boundaries of brain regions defined according to a standard atlas of the rat brain. This method and accompanying software implementation (Matlab, Labview) allow for compact data display in a variety of autoradiographic and histologic studies of the structure and function of the rat brain.
Holschneider
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DP
Department of Psychiatry and the Behavioral Sciences, University of Southern California School of Medicine, Los Angeles, CA 90033, USA. holschne@usc.edu
Scremin
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OU
Chialvo
D R
DR
Kay
B P
BP
Maarek
J-M I
JM
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D001345:Autoradiography; D001931:Brain Mapping / Q000295:instrumentation* / Q000379:methods*; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D011877:Radionuclide Imaging; D051381:Rats; D012984:Software
D002250:Carbon Radioisotopes; D000983:Antipyrine; C008135:iodoantipyrine