title: Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones.
abstract: The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity.
authors.affiliation: Combinatorial Chemistry Unit, Barcelona Scientific Park (PCB), Josep Samitier 1-5, E-08028 Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Farrera-Sinfreu
authors.forename: Anna
authors.initials: A
authors.lastname: Aviñó
authors.forename: Isabel
authors.initials: I
authors.lastname: Navarro
authors.forename: Juan
authors.initials: J
authors.lastname: Aymamí
authors.forename: Natàlia G
authors.initials: NG
authors.lastname: Beteta
authors.forename: Sònia
authors.initials: S
authors.lastname: Varón
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pérez-Tomás
authors.forename: Wilmar
authors.initials: W
authors.lastname: Castillo-Avila
authors.forename: Ramon
authors.initials: R
authors.lastname: Eritja
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Miriam
authors.initials: M
authors.lastname: Royo
mesh_terms: D000577:Amides / Q000737:chemistry*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000596:Amino Acids; D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D010455:Peptides