Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma interferon responses to M. vaccae cell wall skeleton.
Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.
Rodríguez-Güell
Elisabeth
E
Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain.
Agustí
Gemma
G
Corominas
Mercè
M
Cardona
Pere-Joan
PJ
Luquin
Marina
M
Julián
Esther
E
D019264:Adoptive Transfer; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D017358:Cell Wall Skeleton / Q000008:administration & dosage* / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis*; D051379:Mice; D009161:Mycobacterium / Q000737:chemistry* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000628:therapy
D001428:Bacterial Vaccines; D017358:Cell Wall Skeleton; D007371:Interferon-gamma