Are there effective new strategies for the treatment of acute and chronic GvHD?
The molecular biology and pathophysiology underlying graft-versus-host disease (GvHD) remains an area of intensive research. Understanding normal and abnormal developments of both the innate and adaptive immune systems are beginning to provide understanding of the details of relevant pathways. Recent work in gene-expression profiling suggests a critical next step in identifying broader patterns that will stand up to examination in independent data sets and provide a sturdy basis for targeted therapy and preventive measures against GvHD.
Chao
Nelson J
NJ
Division of Cellular Therapy/BMT, Duke University, 2400 Pratt Street, Suite 9011, Box 3961, Durham, NC 27710, USA. nelson.chao@duke.edu
D000818:Animals; D053264:B-Cell Activating Factor / Q000276:immunology; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D053264:B-Cell Activating Factor