Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy.
OBJECTIVE
The objective of this study is to evaluate the efficiency of SOD applied topically in oncologic patients affected by acute radiodermatitis.


METHODS
This study includes 57 patients who showed a dermatitis grade 2 or superior; they were administered SOD ointment b.i.d. (40 mg, weekly) and follow-up continued for 12 weeks.


RESULTS
At the end of radiotherapy, 77.1% of the patients ameliorated completely or partially, and at the end of the 12-week period 100% of patients were free of toxicity. No acute toxicity relapses were reported. Response time reduced during radiotherapy, as well as the treatment time at the end of it.


CONCLUSIONS
The employment of SOD topically is efficient in the treatment of radiodermatitis, which is an acute side effect of radiotherapy.
Manzanas García
Alvaro
A
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
López Carrizosa
María Concepción
MC
Vallejo Ocaña
Carmen
C
Samper Ots
Pilar
P
Delgado Pérez
José María
JM
Carretero Accame
Emilia
E
Gómez-Serranillos
Pilar
P
de la Morena del Valle
Luis
L
D000208:Acute Disease; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D009824:Ointments; D011855:Radiodermatitis / Q000188:drug therapy* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D012867:Skin / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D016896:Treatment Outcome
D016166:Free Radical Scavengers; D009824:Ointments; D013482:Superoxide Dismutase