title: Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma.
abstract: OBJECTIVE
  To evaluate the impact of obesity on the posto-perative outcome after hepatic resection in patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  Data from 328 consecutive patients with primary HCC and 60 patients with recurrent HCC were studied. We compared the surgical outcomes between the non-obese group (body mass index: BMI < 25 kg/m(2)) and the obese group (BMI > or = 25 kg/m(2)).
  
  
  RESULTS
  Following curative hepatectomy in patients with primary HCC, the incidence of postoperative complications and the long-term prognosis in the non-obese group (n = 240) were comparable to those in the obese group (n = 88). Among patients with recurrent HCC, the incidence of postoperative complications after repeat hepatectomy was not significantly different between the non-obese group (n = 44) and the obese group (n = 16). However, patients in the obese group showed a significantly poorer long-term prognosis than those in the non-obese group (P < 0.05, five-year survival rate; 51.9% and 92.0%, respectively).
  
  
  CONCLUSIONS
  Obesity alone may not have an adverse effect on the surgical outcomes of patients with primary HCC. However, greater caution seems to be required when planning a repeat hepatectomy for obese patients with recurrent HCC.
authors.affiliation: Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima 730-8619, Japan. tohru@hiroshima-med.jrc.or.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Utsunomiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
authors.forename: Toshihumi
authors.initials: T
authors.lastname: Kameyama
authors.forename: Ayumi
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Megumu
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Shiomi
authors.initials: S
authors.lastname: Aimitsu
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000368:Aged; D015992:Body Mass Index; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008099:Liver / Q000601:surgery; D008113:Liver Neoplasms / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery*; D009765:Obesity / Q000150:complications*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome