title: Facile synthesis of methyl alpha- and beta-D-[6-(3)H]galactofuranosides from D-galacturonic acid. Substrates for the detection of galactofuranosidases.
abstract: Galactofuranose metabolism is a good target for the development of novel chemotherapeutic agents for the treatment of some microbial infections. A simple procedure for the synthesis of methyl (methyl alpha,beta-D-galactopyranosid)uronate followed by NaB(3)H(4) reduction gave a straightforward access to radiolabeled substrates for galactofuranosidases.
authors.affiliation: CIHIDECAR (CONICET), Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, Buenos Aires, Argentina.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bordoni
authors.forename: Carlos
authors.initials: C
authors.lastname: Lima
authors.forename: Karina
authors.initials: K
authors.lastname: Mariño
authors.forename: Rosa M
authors.initials: RM
authors.lastname: de Lederkremer
authors.forename: Carla
authors.initials: C
authors.lastname: Marino
mesh_terms: D005663:Furans / Q000138:chemical synthesis; D006026:Glycoside Hydrolases / Q000378:metabolism; D006603:Hexuronic Acids / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D008756:Methylgalactosides / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014316:Tritium
chemical_list: D005663:Furans; D006603:Hexuronic Acids; D008756:Methylgalactosides; D014316:Tritium; C007819:galacturonic acid; D006026:Glycoside Hydrolases; C023112:exo-beta-D-galactofuranosidase