Pedunculopontine nucleus microelectrode recordings in movement disorder patients.
The pedunculopontine nucleus (PPN) lies within the brainstem reticular formation and is involved in the motor control of gait and posture. Interest has focused recently on the PPN as a target for implantation of chronic deep brain stimulation (DBS) electrodes for Parkinson's disease (PD) and progressive supranuclear palsy (PSP) therapy. The aim of this study was to examine the neurophysiology of the human PPN region and to identify neurophysiological landmarks that may aid the proper placement of DBS electrodes in the nucleus for the treatment of PD and PSP. Neuronal firing and local field potentials were recorded simultaneously from two independently driven microelectrodes during stereotactic neurosurgery for implantation of a unilateral DBS electrode in the PPN in five PD patients and two PSP patients. Within the PPN region, the majority (57%) of the neurons fired randomly while about 21% of the neurons exhibited 'bursty' firing. In addition, 21% of the neurons had a long action potential duration and significantly lower firing rate suggesting they were cholinergic neurons. A change in firing rate produced by passive and/or active contralateral limb movement was observed in 38% of the neurons that were tested in the PPN region. Interestingly, oscillatory local field potential activity in the beta frequency range ( approximately 25 Hz) was also observed in the PPN region. These electrophysiological characteristics of the PPN region provide further support for the proposed role of this region in motor control. It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy.
Weinberger
Moran
M
Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King's College Circle, M5S 1A8, Toronto, ON, Canada. moran.weinberger@utoronto.ca
Hamani
Clement
C
Hutchison
William D
WD
Moro
Elena
E
Lozano
Andres M
AM
Dostrovsky
Jonathan O
JO
D000200:Action Potentials / Q000502:physiology*; D000368:Aged; D002799:Cholinergic Fibers / Q000502:physiology; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D005121:Extremities / Q000294:innervation / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008839:Microelectrodes / Q000592:standards; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D045042:Pedunculopontine Tegmental Nucleus / Q000033:anatomy & histology / Q000502:physiology*; D013238:Stereotaxic Techniques; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology / Q000628:therapy*