title: Magnetic resonance guided focused ultrasound surgery. Ablation of soft tissue at bone-muscle interface in a porcine model.
abstract: BACKGROUND
  Pain management treatments of patients with bone metastases have either efficacy problems or significant side effects. Percutaneous radiofrequency ablation has recently proved to be of palliative value. Magnetic resonance guided focused ultrasound surgery (MRgFUS) uses focused ultrasonic energy to non-invasively create a heat-coagulated lesion deep within the body in a controlled, accurate manner. The surgeon can monitor and control energy deposition in real time. This technology represents a potential treatment modality in oncological surgery. We investigated the ability of two MRgFUS methods to accurately and safely target and ablate soft tissue at its interface with bone.
  
  
  METHODS
  Heat-ablated lesions were created by MRgFUS at the bone-muscle interface of 15 pigs. Two different methods of energy delivery were used. Temperature rise at the target adjacent to bone was monitored by real time MR thermal images. Results were evaluated by MRI (magnetic resonance imaging), nuclear scanning and by histopathological evaluation.
  
  
  RESULTS
  Soft tissue lesion sizes by both methods were in the range of 1-2 cm in diameter. Targeting the focus 'behind' the bone, achieved the same result with a single sonication only. Follow up MRI and histopathological examination of all lesions showed focal damage at its interface with bone and localized damage to the outer cortex on the side closer to the targeted tissue. There was no damage to non-targeted tissue.
  
  
  CONCLUSIONS
  MRgFUS by both energy deposition methods can be used to produce controlled well-localized damage to soft tissue in close proximity to bone, with minimal collateral damage.
authors.affiliation: HaEmek Medical Center, Afula, Israel. kopelmand@bezeqint.net
authors.forename: D
authors.initials: D
authors.lastname: Kopelman
authors.forename: Y
authors.initials: Y
authors.lastname: Inbar
authors.forename: A
authors.initials: A
authors.lastname: Hanannel
authors.forename: R M
authors.initials: RM
authors.lastname: Pfeffer
authors.forename: O
authors.initials: O
authors.lastname: Dogadkin
authors.forename: D
authors.initials: D
authors.lastname: Freundlich
authors.forename: B
authors.initials: B
authors.lastname: Liberman
authors.forename: R
authors.initials: R
authors.lastname: Catane
mesh_terms: D000818:Animals; D001842:Bone and Bones; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional; D023421:Models, Animal; D012983:Soft Tissue Neoplasms / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013552:Swine; D014464:Ultrasonic Therapy / Q000379:methods*