1,2-Alkyl migration as a key element in the invention of cascade reactions catalyzed by pi-acids.
This brief overview highlights recent progress in the field of cascade reactions that are initiated by the activation of a pi-system using platinum and gold catalysts and that are coupled with a 1,2-alkyl migration step. While the reactions discussed aim to rapidly evolve molecular complexity, they are experimentally straightforward and easy to perform. Primarily guided by the type of 1,2-alkyl migration, methods are categorized as shifts to metal carbenoid centers and pinacol-type rearrangements.
Crone
Benedikt
B
Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
Kirsch
Stefan F
SF