title: Clinical features at first visit and rapid disease progression in Parkinson's disease.
abstract: We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.
authors.affiliation: Division of Neurology, Royal University Hospital, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada. lwf127@mail.usask.ca
authors.forename: Leslie W
authors.initials: LW
authors.lastname: Ferguson
authors.forename: Michele L
authors.initials: ML
authors.lastname: Rajput
authors.forename: Nazeem
authors.initials: N
authors.lastname: Muhajarine
authors.forename: Syed M
authors.initials: SM
authors.lastname: Shah
authors.forename: Alexander
authors.initials: A
authors.lastname: Rajput
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000150:complications* / Q000453:epidemiology*; D012189:Retrospective Studies