Novel class of hybrid natural products derived from lupeol as antimalarial agents.
Thirty-four novel hybrid lupeol derivatives (4-18) were prepared and evaluated for antimalarial activity in vitro against Plasmodium falciparum. Three compounds (13d, 16a and 17a) have shown antimalarial activity at lower dose (10 microg mL(-1)) than lupeol.
Kumar
Satish
S
Division of Medicinal and Process Chemistry, India.
Misra
Namita
N
Raj
Kanwal
K
Srivastava
Kumkum
K
Puri
S K
SK
D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000737:chemistry*; D000094042:Lupanes
D000962:Antimalarials; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes