[Place of cancer among the risk factors in venous thromboembolism].
There is a strong association between cancer and venous thromboembolism (VTE). Cancer patients have a seven-fold higher risk of developing VTE as compared with noncancer patients. In the year following the diagnosis of cancer, 1.6% of patients will develop a VTE event. VTE is one of the main cause of death in cancer patients, accounting for about 15% of deaths. On the other hand, cancer patients represent 15 to 20% of all VTE cases. Beyond classical risk factors for VTE, specific risk factors are associated with VTE in cancer patients: tumor site, stage, histological type, treatment, duration of the disease. VTE occurrence is associated with a poorer outcome in cancer patients: a reduced survival is observed in cancer patients with VTE as compared to non-VTE cancer patients. This impact of VTE on prognosis varies according to cancer characteristics. Conversely, evolution of VTE is different in cancer patients, with a higher short-term risk of mortality and a higher risk of recurrences, including on anticoagulant treatment, also modulated by cancer characteristics.
Descourt
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EA 3878, groupe d'étude de la thrombose de Bretagne occidentale, département de médecine interne et de pneumologie, CHU Cavale Blanche, boulevard Tanguy-Prigent, 29609 Brest cedex, France.
Righini
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M
Carrier
M
M
Le Gal
G
G
D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000150:complications*; D011379:Prognosis; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000453:epidemiology*