title: Sequential leukemic infiltration and human herpesvirus optic neuropathy in acute lymphoblastic leukemia.
abstract: Leukemic infiltration is a common cause of optic disk swelling in a patient with acute lymphoblastic leukemia (ALL). Recurrence of optic disk swelling in a patient with previous leukemic infiltration carries a grave prognosis when it is associated with recurrent central nervous system disease. We report a case of recurrent swelling of an optic disk in a patient with T-cell ALL who had previously been treated for CNS relapse with optic nerve involvement. In this case the swelling was associated with cytomegalovirus infection and resolved following treatment with antiviral therapy.
authors.affiliation: Leicester Royal Infirmary, Leicester, United Kingdom. uday.bhatt@gmail.com
authors.forename: Uday Kumar
authors.initials: UK
authors.lastname: Bhatt
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Gregory
authors.forename: Mabrouk S
authors.initials: MS
authors.lastname: Madi
authors.forename: Maria
authors.initials: M
authors.lastname: Fraser
authors.forename: Geoffery H A
authors.initials: GH
authors.lastname: Woodruff
mesh_terms: D000293:Adolescent; D007839:Functional Laterality; D006566:Herpesviridae Infections / Q000473:pathology*; D006801:Humans; D017254:Leukemic Infiltration / Q000473:pathology*; D008297:Male; D009900:Optic Nerve / Q000821:virology*; D009901:Optic Nerve Diseases / Q000821:virology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D014792:Visual Acuity