title: Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives.
abstract: Some new hydrazono 5a,b, thiosemicarbazono 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding beta-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.
authors.affiliation: Photochemistry Department, National Research Centre, Cairo, Egypt. apmihegab65@yahoo.com
authors.forename: Mohamed Ibrahim
authors.initials: MI
authors.lastname: Hegab
authors.forename: Nabil Mahmoud
authors.initials: NM
authors.lastname: Yousef
authors.forename: Hany Fathy
authors.initials: HF
authors.lastname: Nour
authors.forename: Mohey
authors.initials: M
authors.lastname: Ellithey
authors.forename: Mahmoud Soliman
authors.initials: MS
authors.lastname: Arbid
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans