Neurobiology of suicidal behavior. An integration of biological and clinical findings.
Suicide is among the top ten leading causes of death in individuals of all ages. An explanatory model for suicidal behavior that links clinical and psychological risk factors or endophenotypes, to the underlying neurobiological abnormalities associated with suicidal behavior may enhance prediction, help identify treatment options and have heuristic value. Our explanatory model proposes that developmental factors that are biological (genetics) and psychological or clinical (early childhood adversity) may have causal relevance to the disturbances found in subjects with suicidal behavior. In this way, our model integrates findings from several perspectives in suicidology and attempts to explain the relationship between various neurobiological, genetic, and clinical observations in suicide research, offering a comprehensive hypothesis to facilitate understanding of this complex outcome.
Carballo
Juan J
JJ
New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Akamnonu
Chibuikem P
CP
Oquendo
Maria A
MA
D015415:Biomarkers; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000235:genetics*; D004298:Dopamine / Q000134:cerebrospinal fluid / Q000235:genetics*; D005190:Family / Q000523:psychology; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000235:genetics; D009638:Norepinephrine / Q000134:cerebrospinal fluid / Q000235:genetics*; D010641:Phenotype; D011584:Psychology; D012307:Risk Factors; D012701:Serotonin / Q000134:cerebrospinal fluid / Q000235:genetics*; D019966:Substance-Related Disorders / Q000453:epidemiology; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data
D015415:Biomarkers; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine