Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa.
Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM.
Ahmad
Ijaz
I
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing, China. drijaz_chem@yahoo.com
Chen
Shilin
S
Peng
Yong
Y
Chen
Sibao
S
Xu
Lijia
L
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032861:Buddleja; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008958:Models, Molecular; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D039823:Iridoids; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase