title: Frequency-specific electrocochleography indicates that presynaptic and postsynaptic mechanisms of auditory neuropathy exist.
abstract: OBJECTIVE
  The physiological mechanisms underlying auditory neuropathy (AN) remain unclear and it is likely that the multiple disruptions are classified under the broadly defined term. Cochlear implantation is being more widely used in this population to bypass the suspected site-of-lesion although a number of cases have been identified within the Sydney Cochlear Implant Centre where this management strategy has been unsuccessful. It is likely that this relates to the different physiological mechanisms underlying AN.
  
  
  METHODS
  To investigate the site-of-lesion in AN, frequency-specific round window electrocochleography (ECochG) was used to assess local hair-cell, dendritic, and axonal currents generated within the cochlea in 14 subjects with AN and compared with responses from two normally hearing subjects. ECochG results were then compared with electrically evoked auditory brain stem response (EABR) measured after cochlear implantation.
  
  
  RESULTS
  The results of this study demonstrate that two dominant patterns of ECochG waveforms (produced by a high-frequency alternating tone burst) can be identified in this population of AN subjects: (a) gross waveform showing a prolonged summating potential (SP) latency that, in most cases, is followed by a small compound action potential; and (b) gross waveform showing a normal latency SP waveform followed by a broad negative potential [assumed to reflect the dendritic potential (DP) identified in anaesthetized guinea-pigs]. This study demonstrates that in most subjects (n = 7) with a prolonged latency SP but no DP, normal morphology EABR waveforms were elicited for all electrode channels. On the other hand, all subjects (n = 7) who showed a normal latency SP followed by a broad negative DP, showed EABR waveforms that were absent or having poor wave V morphology. The authors' interpretation of this is that ECochG results may provide a classification of AN into pre- and postsynaptic lesions.
  
  
  CONCLUSIONS
  We suggest that a presynaptic and postsynaptic type of AN exist that may have implications for the fitting of cochlear implants.
authors.affiliation: Speech, Hearing and Language Research Centre, Department Linguistics, Macquarie University, NSW, Australia. catherine.mcmahon@ling.mq.edu.au
authors.forename: Catherine M
authors.initials: CM
authors.lastname: McMahon
authors.forename: Robert B
authors.initials: RB
authors.lastname: Patuzzi
authors.forename: William P R
authors.initials: WP
authors.lastname: Gibson
authors.forename: Halit
authors.initials: H
authors.lastname: Sanli
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000502:physiology; D001369:Axons / Q000502:physiology*; D001933:Brain Stem / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003056:Cochlear Nerve / Q000503:physiopathology*; D003638:Deafness / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D003712:Dendrites / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006199:Hair Cells, Auditory, Inner / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012405:Round Window, Ear / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology*; D000160:Vestibulocochlear Nerve Diseases / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology