Vitamin D regulation of cathelicidin in the skin: toward a renaissance of vitamin D in dermatology?
1,25-Dihydroxyvitamin D(3), the active form of vitamin D, is a major regulator of the expression of the cationic antimicrobial peptide cathelicidin, not only in monocytes but also in epidermal keratinocytes. The involvement of cathelicidin in wound healing and skin diseases as diverse as psoriasis, rosacea, and atopic dermatitis may create new opportunities for the use of vitamin D in dermatology.
Segaert
Siegfried
S
Department of Dermatology, University Hospital Leuven, Belgium. Siegfried.Segaert@med.kuleuven.be
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D002117:Calcitriol / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects; D054804:Cathelicidins
D023181:Antimicrobial Cationic Peptides; D014807:Vitamin D; D002117:Calcitriol; D054804:Cathelicidins