title: No change to grey and white matter volumes in bipolar I disorder patients.
abstract: BACKGROUND
  Structural brain imaging is assumed to be a key method to elucidate the underlying neuropathology of bipolar disorder. However, magnetic resonance imaging studies using region of interest analysis and voxel-based morphometry (VBM) revealed quite inconsistent findings. Hence, there is no clear evidence so far for core regions of cortical or subcortical structural abnormalities in bipolar disorder. The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder.
  
  
  METHODS
  Thirty-five patients with bipolar I disorder and 32 healthy controls matched with respect to gender, handedness and education participated in the study. MRI scanning was performed and an optimized VBM analysis was conducted.
  
  
  RESULTS
  We could not observe any significant differences of grey or white matter volumes between patients with bipolar disorder and healthy control subjects. Additional analyses did not reveal significant correlations between grey or white matter volume with number of manic or depressive episodes, duration of illness, existence of psychotic symptoms, and treatment with lithium or antipsychotics.
  
  
  CONCLUSIONS
  With this VBM study we were not able to identify core regions of structural abnormalities in bipolar disorder.
authors.affiliation: Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075, Goettingen, Germany. hscherk@uni-goettingen.de
authors.forename: Harald
authors.initials: H
authors.lastname: Scherk
authors.forename: Claudia
authors.initials: C
authors.lastname: Kemmer
authors.forename: Juliana
authors.initials: J
authors.lastname: Usher
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Reith
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
authors.forename: Oliver
authors.initials: O
authors.lastname: Gruber
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012737:Sex Factors; D013997:Time Factors