title: Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing.
abstract: We have identified a novel HLA-B allele, B*5529. The novel allele differs from HLA-B*5501 by a single nucleotide substitution at codon 479 in exon 3 resulting in an amino acid change from alanine to valine. This alteration neither affects the peptide binding site nor the T-cell receptor (TCR) contact residues. Thus, the newly found allele is estimated to have a low alloreactive potential in case of a mismatch to the most common HLA-B allele B*5501.
authors.affiliation: Center for Tumor Medicine, Institute for Transfusion Medicine, Charité University Medicine, Berlin, Germany. florian.emmerich@charite.de
authors.forename: F
authors.initials: F
authors.lastname: Emmerich
authors.forename: C
authors.initials: C
authors.lastname: Schönemann
authors.forename: L
authors.initials: L
authors.lastname: Galicki
authors.forename: A
authors.initials: A
authors.lastname: Salama
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D005260:Female; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D015235:HLA-B Antigens