title: Antimycobacterial activity of Juglans regia, Juglans mollis, Carya illinoensis and Bocconia frutescens.
abstract: Mycobacterium tuberculosis is a serious worldwide health threat, killing almost 2 million people per year. Alternative antimycobacterial drugs are urgently needed; studies have shown that medicinal plants traditionally used to treat respiratory diseases are a potential source of compounds to treat tuberculosis. This paper studied the antimycobacterial activity of 28 extracts from four different plant species that have been used in traditional Mexican medicine to treat tuberculosis. Bark and leaf crude extracts of Juglans regia L., Juglans mollis Engelm., Carya illinoensis (Wangenh) K. Koch and Bocconia frutescens showed in vitro anti-M. tuberculosis activity. Hexane bark extracts from C. illinoensis, J. mollis and J. regia were the most active with a minimal inhibitory concentration (MIC) of 31, 50 and 100 microg/mL, respectively. Ethanol bark extracts from C. illinoensis and J. mollis showed activity at 100 and 125 microg/mL, respectively. Leaf extracts had the lowest activity. Methanol and hexane leaves extracts from B. frutescens had a MIC of 125 microg/mL. None of the aqueous extracts showed antimycobacterial activity.
authors.affiliation: División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, NL, México.
authors.forename: Delia Elva
authors.initials: DE
authors.lastname: Cruz-Vega
authors.forename: María Julia
authors.initials: MJ
authors.lastname: Verde-Star
authors.forename: Noé
authors.initials: N
authors.lastname: Salinas-González
authors.forename: Bibiana
authors.initials: B
authors.lastname: Rosales-Hernández
authors.forename: Iris
authors.initials: I
authors.lastname: Estrada-García
authors.forename: Patricia
authors.initials: P
authors.lastname: Mendez-Aragón
authors.forename: Pilar
authors.initials: P
authors.lastname: Carranza-Rosales
authors.forename: María Teresa
authors.initials: MT
authors.lastname: González-Garza
authors.forename: Jorge
authors.initials: J
authors.lastname: Castro-Garza
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031325:Carya / Q000737:chemistry*; D031324:Juglans / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D028101:Papaveraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts