title: Classification of acute myocardial ischemia by artificial neural network using echocardiographic strain waveforms.
abstract: Echocardiographic strain waveforms are highly variable, so their interpretation is experience-dependent and subjective. We tested whether an artificial neural network (ANN) can distinguish between strain waveforms obtained at baseline and during experimentally induced acute ischemia. An open-chest model of coronary occlusion and acute ischemia was used in 14 adult pigs. Strain waveforms were obtained using a GE Vivid 7 ultrasound system. An ANN design was implemented in MATLAB, and backpropagation and "leave-one-out" processes were used to train and test it. Specificity of 86% and sensitivity of 87% suggest that ANNs could aid in diagnostic prescreening of echocardiographic strain waveforms.
authors.affiliation: Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.
authors.forename: Eileen M
authors.initials: EM
authors.lastname: McMahon
authors.forename: Josef
authors.initials: J
authors.lastname: Korinek
authors.forename: Shiro
authors.initials: S
authors.lastname: Yoshifuku
authors.forename: Partho P
authors.initials: PP
authors.lastname: Sengupta
authors.forename: Armando
authors.initials: A
authors.lastname: Manduca
authors.forename: Marek
authors.initials: M
authors.lastname: Belohlavek
mesh_terms: D000208:Acute Disease; D000818:Animals; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation*; D004195:Disease Models, Animal; D004452:Echocardiography / Q000295:instrumentation*; D004562:Electrocardiography / Q000295:instrumentation*; D005103:Expert Systems; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016571:Neural Networks, Computer; D011379:Prognosis; D012985:Software Design; D013552:Swine