[Design of equine serum-based Marburg virus immunoglobulin].
Immunoglobulin (Ig) against Marburg fever (MF) has been obtained from the equine serum. In terms of physicochemical and immunobiological properties, the obtained preparation corresponds to the quality of heterologous commercial immunoglobulins. The application of Marburg virus (MV) Ig with a titer of no less than 1:2048 by the emergency prevention scheme 1-2 hours after intraperitoneal inoculation of guinea pigs with MV in a dose of 20-50 LD50 protected 88-100% of the animals from death. MV Ig is recommended for emergency prevention of human MF.
Borisevich
I V
IV
Potryvaeva
N V
NV
Mel'nikov
S A
SA
Evseev
A A
AA
Krasnianskiĭ
V P
VP
Maksimov
V A
VA
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000918:Antibody Specificity; D006168:Guinea Pigs; D006736:Horses; D007114:Immunization; D007136:Immunoglobulins / Q000008:administration & dosage / Q000097:blood / Q000276:immunology*; D007274:Injections, Intraperitoneal; D008379:Marburg Virus Disease / Q000097:blood* / Q000517:prevention & control; D029024:Marburgvirus / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D010215:Papio; D011817:Rabbits; D013997:Time Factors
D000914:Antibodies, Viral; D007136:Immunoglobulins