title: Preventive potential of body mass reduction to lower cardiovascular risk: the Italian Progetto CUORE study.
abstract: OBJECTIVE
  To estimate effects of weight change on incidence of major cardiovascular events in the Italian population-based Progetto CUORE.
  
  
  METHODS
  Prospective observation in 12 Italian population-based cohorts on etiology of cardiovascular disease. Twenty-thousand six-hundred-forty-seven men and women aged 35-69 years without previous CVD, examined at baseline between 1984 and 1993 and followed for median time 8.5 years, with validated first cardiovascular events. Standardised anthropometric variables, lifestyle and biochemical risk factors for CVD; major cardiovascular events as end-points.
  
  
  RESULTS
  Linear regression between BMI and major CVD risk factors was combined with Cox coefficients from a prediction model of CVD, CHD and stroke using major risk factors as dependent variables. Estimated cardiovascular risk reductions with BMI lowered by 1 to 3 U were: for men 3.8% to 10.9% for all cardiovascular events, 4.2% to 12.1% for CHD, and 2.3% to 6.9% for stroke; for women 2.8% to 8.1% for all cardiovascular events, 3.4% to 9.8% for CHD, and 2.1% to 6.2% for stroke.
  
  
  CONCLUSIONS
  Body weight level influences cardiovascular disease risk in the Italian population.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Federico II University, Via Pansini, 5, 80131 Naples, Italy. spanico@unina.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Luigi
authors.initials: L
authors.lastname: Palmieri
authors.forename: Chiara
authors.initials: C
authors.lastname: Donfrancesco
authors.forename: Diego
authors.initials: D
authors.lastname: Vanuzzo
authors.forename: Paolo
authors.initials: P
authors.lastname: Chiodini
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Cesana
authors.forename: Marco
authors.initials: M
authors.lastname: Ferrario
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Lorenza
authors.initials: L
authors.lastname: Pilotto
authors.forename: Roberto
authors.initials: R
authors.lastname: Sega
authors.forename: Simona
authors.initials: S
authors.lastname: Giampaoli
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Stamler
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy*; D012307:Risk Factors; D040242:Risk Reduction Behavior; D015431:Weight Loss