The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring.
This study investigates the effects of diet-induced changes in maternal body condition on glucose tolerance in sheep. Welsh Mountain ewes were established, by dietary manipulation, at a body condition score of 2 (lower body condition [LBCS], n = 17) or >3 (higher body condition [HBCS], n = 19) prior to and during pregnancy. Birth weight and postnatal growth were similar in LBCS and HBCS offspring. In young adulthood, LBCS offspring had increased fasting glucose levels (3.8 +/- 0.07 vs 3.6 +/- 0.05 mM, P < .05), poorer glucose tolerance (2274 +/- 22.6 vs 2161 +/- 33 min/mM, P < .01), and reduced insulin secretion (0.58 +/- 0.05 vs 0.71 +/- 0.07 nM/min, P = .07). Increased fasting glycemia, mild glucose intolerance, and impaired initial insulin secretory response, as observed in LBCS offspring, are indictors of increased diabetes risk in humans. These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance.
Cripps
Roselle L
RL
Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK. rlc34@cam.ac.uk
Green
Lucy R
LR
Thompson
John
J
Martin-Gronert
Malgorzata S
MS
Monk
Melanie
M
Sheldon
I Martin
IM
Hanson
Mark A
MA
Hales
C N
CN
Ozanne
Susan E
SE
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001824:Body Constitution / Q000502:physiology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009752:Nutritional Status / Q000502:physiology*; D011247:Pregnancy; D011897:Random Allocation; D012756:Sheep / Q000097:blood / Q000196:embryology / Q000378:metabolism / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose