Amphotericin B-deoxycholate overdose due to administration error in pediatric patients.
Due to the similarity of their generic names, the use of amphotericin B-deoxycholate and liposomal amphotericin B could cause confusion in daily practice. We report two cases of amphotericin B-deoxycholate overdose in infants due to administration errors which raises the issue that the use of this antifungal agent should be questioned because of its severe side effects.
Groeneveld
Susanne
S
Department of Pediatrics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Verweij
Paul E
PE
Hek
Louis Van't
LV
Bökkerink
Jos P M
JP
Warris
Adilia
A
D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects / Q000506:poisoning* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000506:poisoning*; D002626:Chemistry, Pharmaceutical; D003840:Deoxycholic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000506:poisoning*; D004338:Drug Combinations; D062787:Drug Overdose; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008508:Medication Errors
D000935:Antifungal Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination