title: Hollow silica nanocontainers as drug delivery vehicles.
abstract: Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
authors.affiliation: Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-752, Korea.
authors.forename: Jaemoon
authors.initials: J
authors.lastname: Yang
authors.forename: Jaewon
authors.initials: J
authors.lastname: Lee
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Kang
authors.forename: Kwangyeol
authors.initials: K
authors.lastname: Lee
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
authors.forename: Seungjoo
authors.initials: S
authors.lastname: Haam
mesh_terms: D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005290:Ferric Compounds; D053769:Nanocapsules / Q000737:chemistry*; D012822:Silicon Dioxide; D013329:Structure-Activity Relationship
chemical_list: D005290:Ferric Compounds; D053769:Nanocapsules; C001215:ferrite; D012822:Silicon Dioxide; D004317:Doxorubicin