[Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound].
BACKGROUND
Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers.


METHODS
An 86-year-old woman presented ulceration on a pacemaker implantation scar despite complete initial wound healing. Nicorandil had been initiated three months earlier. None of the usual causes of ulceration of a pacemaker scar were seen. Complete and permanent wound-healing was achieved 12 days after discontinuation of nicorandil.


CONCLUSIONS
This is the first reported case of cutaneous ulceration on a vulnerable area of skin ascribable to high-dose nicorandil.
Jennesseaux
I
I
Service de dermatologie, centre hospitalier Jacques-Monod, B.P. 24, 76083 Le Havre cedex, France.
Carre-Gislard
D
D
Bravard
P
P
D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D002921:Cicatrix / Q000473:pathology; D003231:Conjunctivitis / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020108:Nicorandil / Q000009:adverse effects*; D010138:Pacemaker, Artificial; D012883:Skin Ulcer / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D020108:Nicorandil