Transmission of simian immunodeficiency virus carrying multiple cytotoxic T-lymphocyte escape mutations with diminished replicative ability can result in AIDS progression in rhesus macaques.
Cytotoxic T-lymphocyte (CTL) responses frequently select for immunodeficiency virus mutations that result in escape from CTL recognition with viral fitness costs. The replication in vivo of such viruses carrying not single but multiple escape mutations in the absence of the CTL pressure has remained undetermined. Here, we have examined the replication of simian immunodeficiency virus (SIV) with five gag mutations selected in a macaque possessing the major histocompatibility complex haplotype 90-120-Ia after its transmission into 90-120-Ia-negative macaques. Our results showed that even such a "crippled" SIV infection can result in persistent viral replication, multiple reversions, and AIDS progression.
Seki
Sayuri
S
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Kawada
Miki
M
Takeda
Akiko
A
Igarashi
Hiroko
H
Sata
Tetsutaro
T
Matano
Tetsuro
T
D000818:Animals; D015683:Gene Products, gag / Q000235:genetics; D008253:Macaca mulatta; D009154:Mutation; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000254:growth & development / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019562:Viral Load
D015683:Gene Products, gag; C115853:simian immunodeficiency virus gag p55