Pharmacological neuroprotective therapy for acute spinal cord injury: state of the art.
After spinal cord injury, a number of destructive events developed immediately after the primary insult increase tissue damage. Several therapeutic approaches are directed to neutralize these phenomena. The present manuscript revises diverse pharmacological treatments used to promote neuroprotection, both in clinical and experimental acute spinal cord injuries.
Martiñón
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Unidad de Investigación Médica en Enfermedades Neurológicas, HE, CMN Siglo XXI, IMSS, Av. Cuauhtemoc No. 330, Col. Doctores, CP 06720, México City, México.
Ibarra
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D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002154:Calpain / Q000037:antagonists & inhibitors / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D020104:Immunophilins / Q000037:antagonists & inhibitors / Q000378:metabolism; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology
D016861:Cyclooxygenase Inhibitors; D018696:Neuroprotective Agents; D002154:Calpain; D020104:Immunophilins