title: Proactive nurse management guidelines for managing intensive chemotherapy regimens in patients with advanced gastric cancer.
abstract: Patients with advanced gastric cancer have a poor prognosis. Intensive chemotherapy regimens may be effective for the treatment of this disease but may be associated with a significant number of severe adverse events. Optimal management of these adverse events can improve outcome for the patient. Currently, there is little information in the literature about the nursing management of this particular group of patients. This American study involved the nursing management of all patients with gastric or gastroesophageal cancer enrolled in clinical trials at a single center. Patients had close contact with research nurses and received education about adverse events and how to deal with them. Patients completed a detailed treatment diary for each cycle of treatment. Protocols were established for the management of emergent adverse events. The guidelines developed during this study could help to underpin the role of the specialist oncology nurse and improve the management of patients undergoing intensive chemotherapy for gastric and gastroesophageal cancer, with the potential of improving outcome, or at least quality of life, for the patients. The nurses' role should be pivotal in the management of intensive chemotherapy for gastric and gastroesophageal cancer.
authors.affiliation: Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA. jsbaker@mdanderson.org
authors.forename: J
authors.initials: J
authors.lastname: Baker
authors.forename: J A
authors.initials: JA
authors.lastname: Ajani
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D015400:Clinical Nursing Research; D002985:Clinical Protocols; D002986:Clinical Trials as Topic / Q000451:nursing; D016903:Drug Monitoring / Q000451:nursing; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D006801:Humans; D009720:Nurse Clinicians / Q000458:organization & administration / Q000523:psychology; D024802:Nurse's Role; D009730:Nursing Assessment; D009859:Oncology Nursing / Q000458:organization & administration*; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011788:Quality of Life / Q000523:psychology; D012108:Research Personnel / Q000458:organization & administration / Q000523:psychology; D012944:Social Support; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000451:nursing* / Q000523:psychology; D013781:Texas; D017749:Total Quality Management / Q000458:organization & administration; D016896:Treatment Outcome