title: Hesperidin in orange juice reduces the absorption of celiprolol in rats.
abstract: It has been reported that the intestinal absorption of celiprolol, an antihypertensive drug, is inhibited when it is taken with orange juice; it has been suggested that element(s) in citrus juice are responsible for this. In the present study, the pharmacokinetic interaction between celiprolol and orange juice was characterized through in vivo experiments with rats. Celiprolol 5 mg/kg was injected into the rat duodenum together with 5 ml/kg of neutralized orange juice or the same concentration of hesperidin as in the orange juice. Plasma celiprolol concentrations were measured by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). Concomitant administration of orange juice or hesperidin with celiprolol significantly decreased the area under the plasma concentration-time curve (AUC) by 74% and 75%, respectively, compared with control. These findings suggest that hesperidin is responsible for the decreased absorption of celiprolol and that orange juice taken with celiprolol has an inhibiting effect on intestinal absorption of the drug.
authors.affiliation: Department of Pharmaceutics, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. uesawa@my-pharm.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Uesawa
authors.forename: Kiminori
authors.initials: K
authors.lastname: Mohri
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001628:Beverages; D017272:Celiprolol / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid; D032084:Citrus sinensis / Q000737:chemistry*; D018565:Food-Drug Interactions; D006569:Hesperidin / Q000494:pharmacology*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000959:Antihypertensive Agents; D017272:Celiprolol; D006569:Hesperidin