title: Normal cytochrome C oxidase activity in prion protein gene-deficient mice.
abstract: Cytochrome c oxidases of prion protein (PrP) gene-deficient (Prnp(-/-)) and Prnp(+/+) mice were examined in vivo and in vitro. Non-invasive near-infrared spectra revealed that oxidation of copper and heme a+a(3) in cytochrome c oxidase of Prnp(-/-) mice was similar to that in Prnp(+/+) mice. Biochemical analysis of mitochondrial fractions also supported the results. PrP might not be involved in regulation of cytochrome c oxidase.
authors.affiliation: Department of Virology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. sakudo@biken.osaka-u.ac.jp
authors.forename: Akikazu
authors.initials: A
authors.lastname: Sakudo
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Taniuchi
authors.forename: Takanori
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Onodera
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ikuta
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006418:Heme / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008928:Mitochondria / Q000201:enzymology; D011328:Prions / Q000235:genetics*
chemical_list: D011328:Prions; D006418:Heme; D003300:Copper; D003576:Electron Transport Complex IV