[Correlation of PI3K-Akt signal pathway to apoptosis of tumor cells].
PI3K-Akt signal pathway is an important intracellular signal transduction pathway. It plays important roles in cell apoptosis and survival by affecting the activity of downstream effector molecules, and it is closely associated with the development and progression of human tumors, therefore, PI3K and Akt might be potential targets for tumor therapy. This article reviewed recent progress on the composition, function, regulation and anti-apoptosis of PI3K-Akt signal pathway, and discussed its potential application to tumor gene therapy.
Huang
Xiu-Lan
XL
Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, P. R. China.
Cui
Guo-Hui
GH
Zhou
Ke-Yuan
KY
D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt