Photo-onycholysis caused by olanzapine and aripiprazole.
Photo-onycholysis associated with drugs is an uncommon disorder. We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine. Substitution of olanzapine with aripiprazole further exacerbated the problem. The possible mechanisms of photo-onycholysis development by modern atypical antipsychotics, modulating dopamine receptors, are discussed.
Gregoriou
Stamatis
S
Department of Dermatology, University of Athens, A. Sygros Hospital, Athens, Greece.
Karagiorga
Theodora
T
Stratigos
Alexander
A
Volonakis
Kyriakos
K
Kontochristopoulos
George
G
Rigopoulos
Dimitris
D
D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000068180:Aripiprazole; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy; D004890:Erythema / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D000077152:Olanzapine; D054039:Onycholysis / Q000139:chemically induced* / Q000175:diagnosis; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000175:diagnosis; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D015363:Quinolones / Q000009:adverse effects* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D001569:Benzodiazepines; D000068180:Aripiprazole; D000077152:Olanzapine