title: Dioxadispiroketal Compounds and a Potential Acyclic Precursor from Amomum aculeatum.
abstract: Four new compounds having an unusual 1,7-dioxadispiro[5.1.5.2]-12-ene-11-one tricyclic ring system (1-4), their potential precursor, 5R-hydroxy-1-(4-hydroxyl-phenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1-4, 6 and 7 showed cytotoxic activity against several human cancer cell lines.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Angela A
authors.initials: AA
authors.lastname: Salim
authors.forename: Bao-Ning
authors.initials: BN
authors.lastname: Su
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Agus
authors.initials: A
authors.lastname: Ruskandi
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn