title: Feasibility of ultrasound phase contrast for heating localization.
abstract: Ultrasound-based methods for temperature monitoring could greatly assist focused ultrasound visualization and treatment planning based on sound speed-induced change in phase as a function of temperature. A method is presented that uses reflex transmission integration, planar projection, and tomographic reconstruction techniques to visualize phase contrast by measuring the sound field before and after heat deposition. Results from experiments and numerical simulations employing a through-transmission setup are presented to demonstrate feasibility of using phase contrast methods for identifying temperature change. A 1.088-MHz focused transducer was used to interrogate a medium with a phase contrast feature, following measurement of the baseline reference field with a hydrophone. A thermal plume in water and a tissue phantom with multiple water columns was used in separate experiments to produce a phase contrast. The reference and phase contrast field scans were numerically backprojected and the phase difference correctly identified the position and orientation of the features. The peak temperature reconstructed from the phase shift was within 0.2 degrees C of the measured temperature in the plume. Simulated results were in good agreement with experimental results. Finally, employment of reflex transmission imaging techniques for adopting a pulse-echo arrangement was simulated, and its future experimental application is discussed.
authors.affiliation: Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. cfarny@bwh.harvard.edu
authors.forename: Caleb H
authors.initials: CH
authors.lastname: Farny
authors.forename: Greg T
authors.initials: GT
authors.lastname: Clement
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D006358:Hot Temperature; D008962:Models, Theoretical; D013016:Sound; D013696:Temperature; D014465:Ultrasonics