title: Contraception in hereditary angioedema.
abstract: OBJECTIVE
  To report a case of successful use of a transdermal contraceptive in a patient with hereditary angioedema.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  A patient who had used oral contraceptives contracted SC and submucosal tumefaction every 1 or 2 months. She was diagnosed with type I hereditary angioedema. It was determined that she was complement C4 deficient and C1-inhibitor quantitative deficient but functional C1-inhibitor normal. After she was diagnosed, the use of oral contraceptives was contraindicated.
  
  
  METHODS
  Oral contraceptives were suspended, and a hormonal transdermal contraceptive was started.
  
  
  METHODS
  The absence of symptoms after 26 months using a transdermal contraceptive.
  
  
  RESULTS
  After 26 months of using this treatment, the patient has not experienced any symptoms of the hereditary angioedema.
  
  
  CONCLUSIONS
  The use of hormonal contraceptives transdermally can be an alternative in patients with hereditary angioedema.
authors.affiliation: Obstetrics and Gynaecology Department, Health Sciences Faculty, School of Medicine, Andres Bello University, Santiago, Chile. pab.sanhueza@uandresbello.edu
authors.forename: Pablo I
authors.initials: PI
authors.lastname: Sanhueza
mesh_terms: D000279:Administration, Cutaneous; D054179:Angioedemas, Hereditary / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009644:Norgestrel / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; C511292:Ortho Evra; D009644:Norgestrel; D004997:Ethinyl Estradiol