title: Comparison study of a long-pulse pulsed dye laser and a long-pulse pulsed alexandrite laser in the treatment of port wine stains.
abstract: BACKGROUND
  Port wine stains (PWSs) are commonly treated by the pulsed dye laser. Recently, a long-pulse pulsed alexandrite laser was used to treat bulky vascular malformations.
  
  
  OBJECTIVE
  In the present study, we compare the efficacy and complications of the long-pulse pulsed dye laser (LPPDL) and the long-pulse pulsed alexandrite laser (LPPAL) in the treatment of PWSs.
  
  
  METHODS
  Eleven patients with Fitzpatrick skin types III-IV were enrolled in this study. One section of each patient's PWS was treated with LPPDL and another section was treated with LPPAL. The patients' PWSs were evaluated for efficacy of elimination of erythema and for treatment-related side effects.
  
  
  RESULTS
  Both LPPDL and LPPAL treatment are effective in the treatment of PWSs. Hyperpigmentation was seen in two areas treated with LPPDL and in three areas treated with LPPAL. Hypopigmentation was seen in one area treated with LPPAL, but not in any of the areas treated with LPPDL. There was no scarring.
  
  
  CONCLUSIONS
  LPPAL works best with hypertrophic, purple PWSs, while LPPDL yields better clinical improvements with the flat, pink PWSs. Targeting of deoxyhemoglobin, deeper penetration, and higher fluence may explain the effectiveness of LPPAL in purple, hypertrophic PWSs. However, there is a risk of dyspigmentation when using the LPPAL.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan. newlilili@hotmail.com
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Taro
authors.initials: T
authors.lastname: Kono
authors.forename: William Frederick
authors.initials: WF
authors.lastname: Groff
authors.forename: Henry H
authors.initials: HH
authors.lastname: Chan
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kitazawa
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nozaki
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology; D017496:Hypopigmentation / Q000209:etiology; D007223:Infant; D054025:Lasers, Dye; D053844:Lasers, Solid-State; D008297:Male; D008875:Middle Aged; D019339:Port-Wine Stain / Q000601:surgery*