Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept.
Antioxidant-rich diets are associated with reduced asthma prevalence. However, direct evidence that altering intake of antioxidant-rich foods affects asthma is lacking. The objective was to investigate changes in asthma and airway inflammation resulting from a low antioxidant diet and subsequent use of lycopene-rich treatments. Asthmatic adults (n=32) consumed a low antioxidant diet for 10 days, then commenced a randomized, cross-over trial involving 3 x 7 day treatment arms (placebo, tomato extract (45 mg lycopene/day) and tomato juice (45 mg lycopene/day)). With consumption of a low antioxidant diet, plasma carotenoid concentrations decreased, Asthma Control Score worsened, %FEV(1) and %FVC decreased and %sputum neutrophils increased. Treatment with both tomato juice and extract reduced airway neutrophil influx. Treatment with tomato extract also reduced sputum neutrophil elastase activity. In conclusion, dietary antioxidant consumption modifies clinical asthma outcomes. Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention.
Wood
Lisa G
LG
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia. lisa.wood@newcastle.edu.au
Garg
Manohar L
ML
Powell
Heather
H
Gibson
Peter G
PG
D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001628:Beverages; D002338:Carotenoids / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D019272:Leukocyte Elastase / Q000378:metabolism; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010936:Plant Extracts / Q000627:therapeutic use; D012720:Severity of Illness Index; D013183:Sputum / Q000166:cytology; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects
D018927:Anti-Asthmatic Agents; D000975:Antioxidants; D010936:Plant Extracts; D002338:Carotenoids; D019272:Leukocyte Elastase; D000077276:Lycopene