Physical activity prevents bone loss in premenopausal women with rheumatoid arthritis: a cohort study.
The aim of the study was to compare the bone loss and the influence of physical activity between premenopausal women with rheumatoid arthritis (RA) and healthy women. A total of 71 patients with RA and 29 healthy premenopausal women with the criteria of the American College of Rheumatology for RA were followed for 2 years. Of these 85% were Caucasian, aged 38 +/- 6.6 years and with a duration of disease of 88 +/- 50 months and 48 (71.8%) used GC, mean daily dose, 7.3 +/- 3.5 mg. There was a reduction in the T-score of the femoral neck (P = 0.04) and in the Ward region (P = 0.05) in RA. Through logistic regression, it was found that sedentarism was a risk factor for osteopenia in RA, with relative risk of 1.6 (IC = 1.238-1.734). Moderate physical activity reduced the risk of osteopenia by 50%. Sedentarism and low weight are the main factors associated with bone loss. Physical activity reduces bone loss. Early preventive and therapeutic measures must be encouraged.
Tourinho
Tatiana Freitas
TF
Departamento de Medicina Interna, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. tatianft@yahoo.com.br
Capp
Edison
E
Brenol
João Carlos
JC
Stein
Airton
A
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000517:prevention & control; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008159:Lumbar Vertebrae; D009043:Motor Activity; D010024:Osteoporosis / Q000453:epidemiology* / Q000517:prevention & control*; D017697:Premenopause; D012307:Risk Factors; D012720:Severity of Illness Index
D018501:Antirheumatic Agents; D005938:Glucocorticoids