[Effect of GBV-C/HIV coinfection on HIV/AIDS disease progression and HIV replication].
Several research groups have recently reported that persistent GB virus C (GBV-C) co-infected with human immunodeficiency virus (HIV) leads to slower AIDSs disease progression than HIV-1 infection alone. However, these findings were not confirmed by several other studies. To investigate the association between GBV-C replication and plasma HIV loads and CD4+ T cell counts, 203 HIV-1 positive former blood/plasma donors(FBDs) were enrolled from Fuyang city of Anhui Province in China. Plasma specimens were collected from them and were tested for GBV-C using RT-PCR and ELISA. Out of 203 specimens, 52 (25.6%) cases were positive for GBV-C, including 35 male (67.3%) and 17 female (32.7%) cases. No significant association was identified between GBV-C infection and CD4+ T-cell counts or between GBV-C infection and HIV viral loads. Since all the subjects studied were naive to ART, the influence of therapy on AIDS disease progression was ruled out in this study. Overall, our data indicated that HIV-1 positive male FBDs were prone to be infected, GBV-C coinfection with HIV-1 does not significantly influence HIV/AIDS disease progression during the late stage of chronic HIV-1 infection.
Zhu
Ting
T
National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, China.
Ding
Xin-Ping
XP
Wan
Yan-Min
YM
Liu
Lian-Xing
LX
Peng
Hong
H
Huang
Xiang-Gang
XG
Feng
Yan-Meng
YM
Wu
Chao
C
Ruan
Yu-Hua
YH
Han
Li-Feng
LF
Xing
Hui
H
Wang
Jian-Jun
JJ
Su
Bing
B
Xu
Chen
C
Xu
Jian-Qing
JQ
Shao
Yi-Ming
YM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology / Q000821:virology*; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D018178:Flaviviridae Infections / Q000276:immunology / Q000821:virology*; D029407:GB virus C; D015497:HIV-1 / Q000502:physiology*; D006525:Hepatitis, Viral, Human / Q000276:immunology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D014779:Virus Replication
D012367:RNA, Viral