title: [Macroscopic subtypes of asbestosis in relation to the amount of asbestos in 63 Japanese autopsy cases].
abstract: Atelectatic induration (AI) and honeycombing (HNCB) are two distinct macroscopic features of asbestosis. The current study was undertaken to clarify whether or not there might be a relation between the macroscopic type of asbestosis and burden of asbestos fibers in the lung. The material (N = 63) derived from 58 autopsies and 5 surgically removed lungs with lung cancers, which comprised 22 cases of AI (mean age: 67 years: 20 males and 2 females) and 41 cases of HNCB (mean age: 66 years: 38 men and 3 women) types of asbestosis, respectively. The quantification of asbestos bodies (AB) and fibers (AF) was carried out using Kohyama's method. The AI type showed 260,000 +/- 460,000 AB per 1g of wet lung and 920,000 +/- 1,360,000 AF per 1g of dry lung, whereas HNCB showed 44,000 +/- 93,000 AB and 200,000 +/- 490,000 AF, respectively. These differences were statistically significant between the types of asbestosis (p < 0.01). Diffuse pleural thickening and upper lobe involvement were more advanced in the AI type and the differences were statistically significant between subtypes (p < 0.05). In conclusion, asbestos load is considered to be a factor related to the macroscopic subtype of asbestosis.
authors.affiliation: Division of Pathology, Saitama Cardiovascular-Respiratory Center.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takumi
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Youichirou
authors.initials: Y
authors.lastname: Kobashi
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects* / Q000032:analysis; D001195:Asbestosis / Q000145:classification / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D044466:Asian People; D001344:Autopsy; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D001194:Asbestos