Sarcoidosis in the setting of idiopathic chronic bronchiolitis with airway colonization from P. aeruginosa: treatment with low-dose macrolides.
It has long been suggested that infectious agents may trigger sarcoidosis through their infectious or antigenic properties. A patient with airway colonization from P. aeruginosa in the setting of idiopathic bronchiolitis (IB) mimicking diffuse panbronchiolitis (DPB) developed sarcoidosis. Impressive clinical and radiological improvement of both bronchiolitis and sarcoidosis features was achieved with a one-year treatment with low-dose erythromycin, thus suggesting a possible link between the two conditions in this specific case. Pathogenic hypotheses and therapeutic implications are specifically discussed.
Trisolini
Rocco
R
Thoracic Endoscopy and Pulmonology Unit, Maggiore Hospital, Bologna, Italy. rocco.trisolini@ausl.bologna.it
Cancellieri
Alessandra
A
Paioli
Daniela
D
Burzi
Marcellino
M
Orlandi
Paolo
P
Patelli
Marco
M
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001988:Bronchiolitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D011552:Pseudomonas Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D012137:Respiratory System / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D018942:Macrolides