title: Recurrent venous thromboembolism complicated by heparin-induced thrombocytopenia as a first manifestation of an occult cancer: a case report.
abstract: Heparin-Induced Thrombocytopenia (HIT) is a serious and potentially fatal complication of patients on heparins. Its management is difficult and it can be more complicated in patients with cancer because of the hemorrhagic risk carried out by direct inhibitor of thrombin, the currently approved drug for HIT. At present, it is not clear whether cancer patients also have an increased risk of HIT. We describe the case of a patient with occult cancer at the moment of the index venous thrombosis, who developed Deep Vein Thrombosis (DVT) and concomitant HIT with thrombotic complications (recurrent contra-lateral venous thrombosis). The management of HIT was efficaciously based on the combined use of alternative antithrombotic regimens (Dermatan-Sulphate and Defibrotide), without an increased risk of bleeding. This case highlights the potential relationship between DVT, as first episode of an occult cancer, and the risk of developing HIT. The use of alternative antithrombotic therapy seems to be efficacious even in this high-risk cancer patient.
authors.forename: A
authors.initials: A
authors.lastname: Pinto
authors.forename: A
authors.initials: A
authors.lastname: Tuttolomondo
authors.forename: P
authors.initials: P
authors.lastname: Fernandez
authors.forename: S
authors.initials: S
authors.lastname: Siragusa
authors.forename: D
authors.initials: D
authors.lastname: Di Raimondo
authors.forename: A
authors.initials: A
authors.lastname: Malato
authors.forename: R
authors.initials: R
authors.lastname: Di Sciacca
authors.forename: S
authors.initials: S
authors.lastname: La Placa
authors.forename: S
authors.initials: S
authors.lastname: Miceli
authors.forename: G
authors.initials: G
authors.lastname: Licata
mesh_terms: D000368:Aged; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D012008:Recurrence; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*; D054556:Venous Thromboembolism / Q000209:etiology*
chemical_list: D006493:Heparin