title: Prevention of chemotherapy-induced alopecia in rodent models.
abstract: Alopecia (hair loss) is experienced by thousands of cancer patients every year. Substantial-to-severe alopecia is induced by anthracyclines (e.g., adriamycin), taxanes (e.g., taxol), alkylating compounds (e.g., cyclophosphamide), and the topisomerase inhibitor etoposide, agents that are widely used in the treatment of leukemias and breast, lung, ovarian, and bladder cancers. Currently, no treatment appears to be generally effective in reliably preventing this secondary effect of chemotherapy. We observed in experiments using different rodent models that localized administration of heat or subcutaneous/intradermal injection of geldanamycin or 17-(allylamino)-17-demethoxygeldanamycin induced a stress protein response in hair follicles and effectively prevented alopecia from adriamycin, cyclophosphamide, taxol, and etoposide. Model tumor therapy experiments support the presumption that such localized hair-saving treatment does not negatively affect chemotherapy efficacy.
authors.affiliation: Department of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Joaquin J
authors.initials: JJ
authors.lastname: Jimenez
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Roberts
authors.forename: Jessica
authors.initials: J
authors.lastname: Mejia
authors.forename: Lucia M
authors.initials: LM
authors.lastname: Mauro
authors.forename: John W
authors.initials: JW
authors.lastname: Munson
authors.forename: George W
authors.initials: GW
authors.lastname: Elgart
authors.forename: Elizabeth Alvarez
authors.initials: EA
authors.lastname: Connelly
authors.forename: Qingbin
authors.initials: Q
authors.lastname: Chen
authors.forename: Jiangying
authors.initials: J
authors.lastname: Zou
authors.forename: Carlos
authors.initials: C
authors.lastname: Goldenberg
authors.forename: Richard
authors.initials: R
authors.lastname: Voellmy
mesh_terms: D000505:Alopecia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D016227:Benzoquinones / Q000008:administration & dosage / Q000627:therapeutic use*; D016466:CHO Cells / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D047029:Lactams, Macrocyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D006360:Heat-Shock Proteins; D047029:Lactams, Macrocyclic; C112765:tanespimycin; C001277:geldanamycin