A microwave promoted and Lewis acid catalysed solventless approach to 4-azasteroids.
The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction.
Borthakur
Moyurima
M
Medicinal Chemistry Division, North-East Institute of Science and Technology, Jorhat 785006, Assam, India.
Boruah
Romesh C
RC
D000143:Acids / Q000737:chemistry*; D001378:Azasteroids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008872:Microwaves; D012997:Solvents / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000143:Acids; D001378:Azasteroids; D012997:Solvents