In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia.
A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.
Babincov
M
M
Department of Nuclear Physics and Biophysics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk
Altanerov
V
V
Altaner
C
C
Bergemann
C
C
Babinec
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004358:Drug Therapy / Q000379:methods; D006979:Hyperthermia, Induced / Q000379:methods*; D008280:Magnetics / Q000627:therapeutic use*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004337:Drug Carriers; D002945:Cisplatin