title: Association of morbid obesity with FTO and INSIG2 allelic variants.
abstract: OBJECTIVE
  To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations.
  
  
  METHODS
  Retrospective analysis of genotype and clinical data.
  
  
  METHODS
  Large rural tertiary care health system.
  
  
  METHODS
  A total of 707 adult patients with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of at least 40 undergoing open or laparoscopic Roux-en-Y gastric bypass operations for morbid obesity or its comorbid medical problems at Geisinger Medical Center, Danville, Pennsylvania.
  
  
  RESULTS
  The mean BMI in the predominantly white female cohort was 51.2. Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both. Mean BMIs in the groups homozygous for each of these genes were not significantly different from nonhomozygotes. However, FTO/INSIG2 double homozygotes and homozygote/heterozygote pairs had significantly higher BMIs than the other groups.
  
  
  CONCLUSIONS
  Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs.
authors.affiliation: Weis Center for Research, Geisinger Clinic, 100 N Academy Ave, Danville, PA 17822, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Chu
authors.forename: Robert
authors.initials: R
authors.lastname: Erdman
authors.forename: Meghan
authors.initials: M
authors.lastname: Susek
authors.forename: Heather
authors.initials: H
authors.lastname: Gerst
authors.forename: Kimberly
authors.initials: K
authors.lastname: Derr
authors.forename: Mouna
authors.initials: M
authors.lastname: Al-Agha
authors.forename: G Craig
authors.initials: GC
authors.lastname: Wood
authors.forename: Christina
authors.initials: C
authors.lastname: Hartman
authors.forename: Stephanie
authors.initials: S
authors.lastname: Yeager
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Blosky
authors.forename: Wanda
authors.initials: W
authors.lastname: Krum
authors.forename: Walter F
authors.initials: WF
authors.lastname: Stewart
authors.forename: David
authors.initials: D
authors.lastname: Carey
authors.forename: Peter
authors.initials: P
authors.lastname: Benotti
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Still
authors.forename: Glenn S
authors.initials: GS
authors.lastname: Gerhard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D050110:Bariatric Surgery; D005260:Female; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012189:Retrospective Studies; D012424:Rural Population
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human