title: Antidepressant-like effect of asiaticoside in mice.
abstract: In the present study, the potential antidepressant properties of asiaticoside were investigated in male mice in three tests -- splash test in the unpredictable chronic mild stress (CMS) model, tail suspension test (TST), forced swimming test (FST) -- with clomipramine being a positive control. In the splash test, asiaticoside (10 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly augmented the frequency of grooming behavior in stressed mice. In the tail suspension test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. In the forced swimming test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. These results suggest that asiaticoside may have antidepressant-like action.
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liang
authors.lastname: Yan Ni Huang
authors.lastname: Si Wei Chen
authors.lastname: Wen Juan Wang
authors.forename: Na
authors.initials: N
authors.lastname: Xu
authors.forename: Shan
authors.initials: S
authors.lastname: Cui
authors.forename: Xing Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.lastname: Yue Nan Liu
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013550:Swimming; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D014315:Triterpenes; D002997:Clomipramine; C004446:asiaticoside