title: Trends in human birth weight across two successive generations.
abstract: OBJECTIVE
  To determine the correlation between parental and offspring birthweight (BW) in India.
  
  
  METHODS
  The study involved two birth cohorts of successive generations. The parental cohort comprised of 472 fathers and 422 mothers from an earlier study. Details of their anthropometry at birth and in adulthood were available. 1525 children born to them comprised the offspring cohort. BW was obtained from hospital records for the offspring cohort. Odds ratios and regression coefficients were calculated to estimate the risks of a low birth weight (LBW) parent producing a LBW baby and quantitate the effects after adjusting for confounders.
  
  
  RESULTS
  A LBW mother had a 2.8 times risk (95%CI 1.2-6.4) of delivering a LBW baby (p=0.02) and a LBW father was twice as likely to produce a LBW baby (OR 2.2; 95%CI 1.0 - 4.8; p=0.05). Every 100g increase in maternal BW was associated with an increase in offspring BW of 14 g; the equivalent figure for paternal BW was 18.1g (p< 0.001 for both). Between the generations, the incidence of LBW decreased from 19.7% to 17.2% (p=0.1). Mean BW increased in males (2846 g vs 2861 g; p=0.59) but not in females (2790 g vs 2743 g; p=0.08).
  
  
  CONCLUSIONS
  Both maternal and paternal BW are strong determinants of offspring BW. The effect of mothers' BW on offspring BW is weaker than that seen in developed nations. Stronger intrauterine constraint exhibited by Indian women secondary to a higher prevalence of growth restriction in utero may be responsible. Paternal effects may be governed by paternal genes inherited by the offspring.
authors.affiliation: Department of Child Health, Christian Medical College, Vellore, India.
authors.forename: B
authors.initials: B
authors.lastname: Agnihotri
authors.forename: B
authors.initials: B
authors.lastname: Antonisamy
authors.forename: G
authors.initials: G
authors.lastname: Priya
authors.forename: C H D
authors.initials: CH
authors.lastname: Fall
authors.forename: P
authors.initials: P
authors.lastname: Raghupathy
mesh_terms: D000886:Anthropometry / Q000379:methods; D001724:Birth Weight / Q000235:genetics; D015331:Cohort Studies; D003906:Developing Countries / Q000706:statistics & numerical data*; D005220:Fathers / Q000706:statistics & numerical data; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D008499:Medical Records; D009035:Mothers / Q000706:statistics & numerical data; D016017:Odds Ratio; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors