Translational dermatology in drug discovery: perspectives for integrating humanized xenograft models and experimental clinical studies.
Application of humanized xenotransplantation disease models and experimental clinical studies in the context of translational research in drug discovery in dermatology is an opportunity to reduce failure due to lack of efficacy in clinical development stage.
Petersen
Thomas K
TK
Biological Research, Discovery, LEO Pharma, 55 Industriparken, DK-2750 Ballerup, Denmark. thomas.petersen@leo-pharma.com
Sørensen
Poul
P
D000818:Animals; D054316:Biomarkers, Pharmacological; D002986:Clinical Trials as Topic; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000276:immunology; D003879:Dermatologic Agents / Q000276:immunology / Q000627:therapeutic use; D004195:Disease Models, Animal; D015195:Drug Design; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D017410:Practice Guidelines as Topic; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology; D012107:Research Design; D013045:Species Specificity; D014183:Transplantation, Heterologous
D054316:Biomarkers, Pharmacological; D003879:Dermatologic Agents