Antiretroviral regimens for treatment-experienced patients with HIV-1 infection.
BACKGROUND
A significant number of treatment-experienced patients with HIV-1 infection develop drug-resistant virus.


OBJECTIVE
To define strategies for managing the antiretroviral-experienced patient and summarize current data with commonly used drugs for this population.


METHODS
This review incorporated data from most recent antiretroviral treatment guidelines, published papers on related topics, and peer-reviewed publications or presentations at research meetings on the safety and efficacy of agents commonly used in this patient population.


CONCLUSIONS
The patient experiencing virologic failure on treatment must be evaluated for their ability to adhere with therapy and to define the number of available active drugs. A viable regimen should include at least two fully active agents, with the goal being to achieve complete virologic suppression.
Lagnese
Meena
M
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Division of HIV Medicine and Infectious Diseases, 1124 W Carson Street, N-24, Torrance, CA 90502, USA.
Daar
Eric S
ES
D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018849:Controlled Clinical Trials as Topic; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D010349:Patient Compliance; D017410:Practice Guidelines as Topic
D019380:Anti-HIV Agents