Polysaccharide-based hydrogels: preparation, characterization, and drug interaction behaviour.
Oxidized alginate (ADA) and oxidized alginate blended with chitosan (ADA-Chit) were prepared in the presence of borax and CaCl 2, and their interactions with an antifolate drug, pyrimethamine (PYR), have been investigated. Tablets with a mean diameter of 1.2 +/- 0.06 cm were produced and drug interactions were performed in dimethyl sulfoxide (DMSO) using isothermal titration calorimetry (ITC). From ITC responses, the enthalpy changes of interaction PYR/materials, Delta int H, have been determined and were found to be -11.73 +/- 0.517 kJ mol (-1) for ADA and -4.86 +/- 0.156 kJ mol (-1) for ADA-Chit. The PYR encapsulation of approximately 75% was achieved for both materials, as measured by UV spectrometer.
Vieira
Eunice F S
EF
Laboratory of Materials and Calorimetry, Departamento de Química/CCET, Universidade Federal de Sergipe, 49100-000, São Cristóvão, Brazil. eunice@ufs.br
Cestari
Antonio R
AR
Airoldi
Claudio
C
Loh
Watson
W
D000464:Alginates / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D001881:Borates / Q000378:metabolism; D002122:Calcium Chloride / Q000378:metabolism; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism*; D004121:Dimethyl Sulfoxide; D004347:Drug Interactions; D020100:Hydrogels / Q000737:chemistry*; D008956:Models, Chemical; D011739:Pyrimethamine / Q000378:metabolism*; D013818:Thermogravimetry
D000464:Alginates; D001881:Borates; D020100:Hydrogels; C018851:borax; D048271:Chitosan; D002122:Calcium Chloride; D004121:Dimethyl Sulfoxide; D011739:Pyrimethamine