Deep brain stimulation of CM/PF of thalamus could be the new elective target for tremor in advanced Parkinson's Disease?
Aim of this study was to investigate whether Deep Brain Stimulation (DBS) of the Centre Median Nucleus/Parafascicular (CM/PF) Complex is useful in reducing extrapyramidal symptoms in advanced Parkinson's Disease (PD) patients. In particular, we compared the action of CM/PF and subthalamic nucleus (STN) DBS on resting hand tremor using EMG surface of ulnar and radial right-hand muscles. Our results show that C/M DBS is very effective in reducing tremor, indicating this complex as a new target in advanced PD patients.
Peppe
A
A
IRCCS Fondazione Santa Lucia, Roma, Italy. a.peppe@hsantalucia.it
Gasbarra
A
A
Stefani
A
A
Chiavalon
C
C
Pierantozzi
M
M
Fermi
E
E
Stanzione
P
P
Caltagirone
C
C
Mazzone
P
P
D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000209:etiology / Q000628:therapy; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D004576:Electromyography; D005260:Female; D006801:Humans; D020646:Intralaminar Thalamic Nuclei / Q000502:physiology*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010300:Parkinson Disease / Q000150:complications*; D014202:Tremor / Q000209:etiology / Q000628:therapy*
D000978:Antiparkinson Agents; D007980:Levodopa