title: The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution.
abstract: OBJECTIVE
  Our objective was to examine the effects of exercise training (EXS) on quality of life (QoL) in highly active antiretroviral therapy (HAART)-treated HIV-positive (HIV+) subjects with body fat redistribution (BFR) in Rwanda.
  
  
  METHODS
  The effects of a randomised controlled trial of EXS on QoL were measured using World Health Organisation Quality of Life (WHOQOL)-BREF in HIV+ subjects with BFR randomised to EXS (n = 50; BFR + EXS) or no exercise training (n = 50; BFR + noEXS).
  
  
  RESULTS
  At 6 months, scores on the psychological [1.3 (0.3) vs. 0.5 (0.1); P < 0.0001], independence [0.6 (0.1) vs. 0.0 (0.0); P < 0.0001], social relationships [0.6 (0.2) vs. 0.0 (0.0); P < 0.0001] and HIV HAART-specific QoL domains [1.4 (0.2) vs. -0.1 (0.2); P < 0.0001] improved more in BFR + EXS than BFR + noEXS group, respectively. Self-esteem [1.3 (0.8) vs. 0.1 (0.6); P < 0.001], body image [1.5 (0.6) vs. 0.0 (0.5); P < 0.001] and emotional stress [1.6 (0.7) vs. 0.2 (0.5); P < 0.001] improved more in the BFR + EXS group than BFR + noEXS group, respectively. Psychological [1.5 (0.2) vs. 1.1 (0.3); P < 0.0001], social relationship [0.8 (0.2) vs. 0.4 (0.2); P < 0.0001], and HIV HAART-specific well-being [1.8 (0.2) vs. 1.0 (0.0); P < 0.0001] improved more in BFR + EXS female than male subjects.
  
  
  CONCLUSIONS
  Exercise training improved several components of QoL in HAART-treated HIV+ African subjects with BFR. Exercise training is an inexpensive and efficacious strategy for improving QoL in HIV+ African subjects, which may improve HAART adherence and treatment initiatives in resource-limited areas of sub-Saharan Africa.
authors.affiliation: Faculty of Allied Health Sciences, Kigali Health Institute, PO Box 3286, Kigali, Rwanda. eumuran@yahoo.co.uk
authors.forename: Eugene
authors.initials: E
authors.lastname: Mutimura
authors.forename: Aimee
authors.initials: A
authors.lastname: Stewart
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Crowther
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Yarasheski
authors.forename: W Todd
authors.initials: WT
authors.lastname: Cade
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000886:Anthropometry; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D001823:Body Composition; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006304:Health Status; D006801:Humans; D008297:Male; D011581:Psychological Tests; D011594:Psychometrics; D011788:Quality of Life; D012432:Rwanda
chemical_list: D044966:Anti-Retroviral Agents