Factors influencing risk of macrosomia in women with gestational diabetes mellitus undergoing intensive diabetic care.
OBJECTIVE
The aim of study was to assess the impact of intensive diabetic care, defined as target values for fasting glucose of 60-90mg/dl and 1-h postprandial glucose of below 130mg/dl, on neonatal birth weight in relation to risk indicators for fetal macrosomia in women with gestational diabetes mellitus (GDM).


METHODS
In women with (N=543) and without GDM (N=1011) age, height, weight, previous GDM, history of macrosomia, family history of type 2 diabetes, parity and weight gain during pregnancy were recorded.


RESULTS
Neonatal birth weight and frequency distribution of macrosomia and infants with small for gestational age did not differ between women with and without GDM. Neonatal birth weight was strongly associated with traditional risk predictors for GDM, such like prior macrosomia (OR 5.03; 95%CI 3.36-7.53), prior GDM (OR 2.52; 95%CI 1.37-4.64) and prepregnancy body mass index (BMI)>23kg/m(2) (OR 1.82; 95%CI 1.27-2.63).


CONCLUSIONS
Neonatal birth weight and the incidence of macrosomia were similar in comparison of pregnancies with and without GDM. In the population of Caucasian women the strongest single predictors for macrosomia were prior macrosomia, BMI>23kg/m(2) and prior GDM.
Ogonowski
Jarosław
J
Department of Endocrinology, Metabolic Diseases and Internal Diseases, Pomeranian Medical University, Ul. Arkońska 4, 71-455 Szczecin, Poland.
Miazgowski
Tomasz
T
Czeszyńska
Maria B
MB
Jaskot
Brygida
B
Kuczyńska
Magdalena
M
Celewicz
Zbigniew
Z
D000328:Adult; D001724:Birth Weight; D016640:Diabetes, Gestational / Q000503:physiopathology* / Q000534:rehabilitation* / Q000628:therapy; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D011044:Poland; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D015430:Weight Gain; D044465:White People
D006442:Glycated Hemoglobin