title: A small molecule inhibitor of alpha4 integrin-dependent cell migration.
abstract: A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Jongkook
authors.initials: J
authors.lastname: Lee
authors.forename: Jiyong
authors.initials: J
authors.lastname: Hong
authors.forename: Tae-Gyu
authors.initials: TG
authors.lastname: Nam
authors.forename: Eric C
authors.initials: EC
authors.lastname: Peters
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Orth
authors.forename: Bernhard H
authors.initials: BH
authors.lastname: Geierstanger
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Goldfinger
authors.forename: Mark H
authors.initials: MH
authors.lastname: Ginsberg
authors.forename: Charles Y
authors.initials: CY
authors.lastname: Cho
authors.forename: Peter G
authors.initials: PG
authors.lastname: Schultz
mesh_terms: D000185:Actinin / Q000037:antagonists & inhibitors / Q000378:metabolism; D000248:Adenosine Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D016466:CHO Cells; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D039441:Integrin alpha4 / Q000187:drug effects / Q000378:metabolism*; D019169:Jurkat Cells; D034622:RNA Interference; D015398:Signal Transduction; D054852:Small Molecule Libraries; D014372:Tubercidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000814:Aniline Compounds; C539856:JK 273; C486593:PARVG protein, human; D054852:Small Molecule Libraries; D000185:Actinin; D039441:Integrin alpha4; D000248:Adenosine Kinase; D014372:Tubercidin