title: Triterpenoid saponins from the fruits and galls of Sapindus mukorossi.
abstract: Six saponins, sapinmusaponin K (1) [hederagenin-3-O-(3-O-acetyl-alpha-L-arabinopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside], sapinmusaponin L (2) [hederagenin-3-O-(4-O-acetyl-alpha-L-arabinopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabino-pyranoside], sapinmusaponin M (3) [hederagenin-3-O-(2,3-O-diacetyl-beta-D-xylopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside], sapinmusaponin N (4) [hederagenin-3-O-(2,4-O-diacetyl-beta-D-xylopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside], sapinmusaponin O (5) [3,7,20(S)-trihydroxydammar-24-ene-3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside], and sapinmusaponin P (6) [3,7,20(R)-trihydroxydammar-24-ene-3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-d-glucopyranoside], along with seven known saponins (7-13), were isolated from fruits and the galls of Sapindus mukorossi. Their structures were elucidated by 1D and 2D NMR spectroscopic techniques and acid hydrolysis. Biological evaluation indicated that saponins 1-4 and 7-13 showed moderate cytotoxicity against several human tumor cell lines.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Wei-Jern
authors.initials: WJ
authors.lastname: Tsai
authors.forename: Sin-Chung
authors.initials: SC
authors.lastname: Liao
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Li-Chuan
authors.initials: LC
authors.lastname: Hsu
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D032127:Sapindus / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D012503:Saponins; D014315:Triterpenes