title: Influence of cefoperazone and azithromycin on the pharmacokinetics of pazufloxacin in rats.
abstract: The effects of cefoperazone and azithromycin administered separately on the pharmacokinetics of pazufloxacin (PZFX) mesilate were investigated in rats. Animals were injected with cefoperazone at a high dose (180 mg/kg) or azithromycin at a dose of 45 mg/kg through the tail vein 10 min before intravenous (i.v.) administration of PZFX (45 mg/kg). Blood concentrations of PZFX were determined by HPLC. Parameters relating to the pharmacokinetic interaction between PZFX and cefoperazone or azithromycin were estimated by a two-compartmental model. The experimental results showed that the presence of azithromycin significantly delayed the t(1/2 beta) and mean residence time (MRT) of PZFX in the plasma. However, no significant changes between the control group and the cefoperazone-treated animals in the pharmacokinetic parameters of PZFX, such as t(1/2 beta), volume of distribution (Vd), area under the curve (AUC) and the clearance (Cl) were observed.
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019540:Area Under Curve; D017963:Azithromycin / Q000494:pharmacology*; D002438:Cefoperazone / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D010078:Oxazines / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D010078:Oxazines; C078052:pazufloxacin; D002438:Cefoperazone; D017963:Azithromycin