title: Extensive chromoblastomycosis caused by Fonsecaea pedrosoi successfully treated with a combination of amphotericin B and itraconazole.
abstract: Chromoblastomycosis is a chronic infection caused by dematiaceous (dark-colored) fungi which affect the skin and subcutaneous tissues, and is characterized by a wide variety of clinical and dermatological features including papillomatous, verrucous and vegetating lesions. Although it has been described world-wide, most cases originate in tropical and sub-tropical areas. In general, present treatments of the disease are unsatisfactory as one of the most common etiologic agents, Fonsecaea pedrosoi is difficult to manage from a therapeutic point of view. We report a case of extensive chromoblastomycosis of 22 years duration caused by F. pedrosoi and review the clinical course, diagnosis and management of this disease.
authors.affiliation: Laboratorio de Estudio de Antígenos, Instituto de Biomedicina/Hospital 'José Gregorio Hernández', Instituto Venezolano de los Seguros Sociales.
authors.forename: A-E
authors.initials: AE
authors.lastname: Paniz-Mondolfi
authors.forename: M-T
authors.initials: MT
authors.lastname: Colella
authors.forename: D-C
authors.initials: DC
authors.lastname: Negrín
authors.forename: N
authors.initials: N
authors.lastname: Aranzazu
authors.forename: M
authors.initials: M
authors.lastname: Oliver
authors.forename: O
authors.initials: O
authors.lastname: Reyes-Jaimes
authors.forename: A-M
authors.initials: AM
authors.lastname: Pérez-Alvarez
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001203:Ascomycota / Q000302:isolation & purification / Q000472:pathogenicity*; D002862:Chromoblastomycosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D003904:Mitosporic Fungi
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B