Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).
Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C ( 1), axinastatin 5 ( 5), bengazoles A ( 6), B ( 7), and E ( 8), manzamine A ( 10), jaspamide ( 11), and neoechinulin A ( 19) has been summarized.
Pettit
George R
GR
Department of Chemstry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA. bpettit@asu.edu
Hogan
Fiona
F
Xu
Jun-Ping
JP
Tan
Rui
R
Nogawa
Toshihiko
T
Cichacz
Zbigniew
Z
Pettit
Robin K
RK
Du
Jiang
J
Ye
Qing-Hua
QH
Cragg
Gordon M
GM
Herald
Cherry L
CL
Hoard
Michael S
MS
Goswami
Animesh
A
Searcy
Justin
J
Tackett
Larry
L
Doubek
Dennis L
DL
Williams
Lee
L
Hooper
John N A
JN
Schmidt
Jean M
JM
Chapuis
Jean-Charles
JC
Tackett
Denise N
DN
Craciunescu
Felicia
F
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002227:Carbazoles; D047630:Depsipeptides; D026121:Indole Alkaloids; D010080:Oxazoles; D010456:Peptides, Cyclic; D010879:Piperazines; C529255:axinastatin 5; C519397:bengazole A; C529257:bengazole B; C529256:bengazole E; C490266:neoechinulin A; C057531:jasplakinolide; C078290:manzamine A; C529254:majusculamide C