Transforming growth factor-beta1 codon 10 polymorphism is associated with acute GVHD after allogenic BMT in Iranian population.
BACKGROUND
Certain cytokine genotypes are associated with acute graft versus host disease (aGVHD) after bone marrow transplantation (BMT). The present study aimed to determine existing association between TGF-beta1 codon 10 polymorphism and aGVHD after HLA-identical sibling BMT in the Iranian population.


METHODS
In a retrospective case-control study, 168 subjects including 84 Iranian HLA-identical sibling BMT donor/recipient pairs were recruited. All of the patients were affected by hematological malignancies (AML=39, ALL=23 and CML=22). PCR-SSP method was performed to determine TGF-beta1 codon 10 T/C polymorphism genotypes.


RESULTS
The frequency of TGF-beta1 codon 10 TT, TC and CC genotypes among all subjects were 26.8%, 33.3% and 39.9% respectively. Recipients with the T allele developed aGVHD significantly less than those without the T allele (odds ratio =0.334, P=0.026).


CONCLUSIONS
Genetic background of TGF-beta1 may be involved as a protective factor in the development of aGVHD in HLA-matched sibling BMT in Iranian population. Moreover, this finding may indicate that the genetic markers in Iranians are, at least to some extent, linked to distinct genetic event from Japanese.
Noori-Daloii
Mohammad Reza
MR
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. nooridaloii@excite.com
Rashidi-Nezhad
Ali
A
Izadi
Pantea
P
Hossein-Nezhad
Arash
A
Sobhani
Maryam
M
Derakhshandeh-Peykar
Pupak
P
Alimoghaddam
Kamran
K
Ghavamzadeh
Ardeshir
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D018912:Arabs / Q000235:genetics*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016022:Case-Control Studies; D002648:Child; D003062:Codon / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000208:ethnology* / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007492:Iran; D007938:Leukemia / Q000208:ethnology / Q000235:genetics / Q000628:therapy; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D003062:Codon; D053773:Transforming Growth Factor beta1