Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development.
SC1 is an extracellular matrix protein that belongs to the SPARC family of matricellular molecules. This anti-adhesive protein localizes to synapses in the adult rat brain and has been postulated to modulate synapse shape. In this study, increased levels of SC1 were detected from postnatal days 10-20, with a peak at postnatal day 15, a period of intense synaptogenesis. During this time, increased colocalization of SC1 with the synaptic marker synaptophysin was observed in synapse-rich regions of the cerebellum and the cerebral cortex. These findings indicate that the pattern of SC1 localization coincided with synaptogenesis during rat postnatal development.
Lively
Starlee
S
Center for the Neurobiology of Stress, University of Toronto at Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4.
Brown
Ian R
IR
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*; D016708:Synaptophysin / Q000378:metabolism
D015415:Biomarkers; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; C503128:Sparcl1 protein, rat; D016708:Synaptophysin