Dynamic hematological disease: a review.
We review the basic characteristics of four periodic hematological disorders (periodic auto-immune hemolytic anemia, cyclical thrombocytopenia, cyclical neutropenia and periodic chronic myelogenous leukemia) and examine the role that mathematical modeling and numerical simulations have played in our understanding of the origin of these diseases and in the regulation of hematopoiesis.
Foley
Catherine
C
Department of Mathematics, Centre for Nonlinear Dynamics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada. H3G 1Y6, foley@math.mcgill.ca
Mackey
Michael C
MC
D003198:Computer Simulation; D006402:Hematologic Diseases / Q000097:blood* / Q000473:pathology*; D006410:Hematopoiesis; D006801:Humans; D008954:Models, Biological