title: Detection of autoantibodies against NMDA-type glutamate receptor in a patient with recurrent optic neuritis and transient cerebral lesions.
abstract: We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum and cerebrospinal fluid. Results of this case study suggest that the development of autoantibodies against NMDA-type glutamate receptors may play a role in the pathogenesis of central nervous system demyelinating diseases.
authors.affiliation: Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. ishikan@hiroshima-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Ishikawa
authors.forename: G
authors.initials: G
authors.lastname: Tajima
authors.forename: S
authors.initials: S
authors.lastname: Hyodo
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D002648:Child; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000276:immunology*; D020938:Epilepsy, Partial, Motor / Q000175:diagnosis / Q000276:immunology; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000276:immunology*; D009471:Neuromyelitis Optica / Q000175:diagnosis / Q000276:immunology*; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000276:immunology*; D010296:Parietal Lobe / Q000473:pathology; D017470:Receptors, Glutamate / Q000276:immunology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D012008:Recurrence
chemical_list: D001323:Autoantibodies; C121001:NR2B NMDA receptor; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C107913:glutamate receptor delta 2