Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans.
We investigated the effect of chronic administration of different pain medications on the activity of the serotonin transporter (SERT) in patients with medication overuse headache (MOH). We measured the kinetic of platelet 5-HT uptake (maximal velocity, Vmax and the Michaelis-Menten constant, Km in patients with overuse of triptans (tMOH, n = 15) or analgesics (aMOH, n = 14) before and after drug withdrawal, as well as in headache-free healthy subjects (n = 15) and patients with episodic migraine (EM, n = 16). Vmax was increased similarly in both, tMOH and aMOH compared to healthy subjects and patients with EM and normalized after withdrawal in parallel to the improvement of headache frequency. Average Km was similar in all groups at baseline and not affected by the withdrawal. The data demonstrate a transient increase of SERT activity in patients with analgesic and triptan induced MOH but do not allow to differentiate whether the increase of serotonin uptake is caused by regular intake of analgesics or triptans or is a consequence of frequent headache attacks.
Ayzenberg
Ilya
I
Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, Essen 45122, Germany. ilya_ayzenberg@yahoo.com
Obermann
Mark
M
Oberman
Mark
M
Leineweber
Kirsten
K
Franke
Leonora
L
Yoon
Min-Suk
MS
Diener
Hans-Christoph
HC
Katsarava
Zaza
Z
D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D014363:Tryptamines / Q000009:adverse effects*
D000700:Analgesics; D050486:Serotonin Plasma Membrane Transport Proteins; D014363:Tryptamines; D012701:Serotonin