A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.
Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by chi(2) test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.
Giacconi
Robertina
R
Immunolgy Center, Section of Nutrition, Immunity, and Ageing, Research Department INRCA, Ancona, Italy. rogiacconi@libero.it
Muti
Elisa
E
Malavolta
Marco
M
Cardelli
Maurizio
M
Pierpaoli
Sara
S
Cipriano
Catia
C
Costarelli
Laura
L
Tesei
Silvia
S
Saba
Vittorio
V
Mocchegiani
Eugenio
E
D000368:Aged; D000375:Aging / Q000235:genetics*; D000596:Amino Acids / Q000235:genetics*; D002340:Carotid Artery Diseases / Q000235:genetics*; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D000596:Amino Acids; D027682:Cation Transport Proteins; D003062:Codon; C498424:SLC39A2 protein, human