Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica.
Three pyridinium inner salt alkaloids, lonijaposides A-C (1-3), based on an unprecedented skeleton of an N-substituted nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid, together with seven known iridoids, have been isolated from the flower buds of Lonicera japonica. Their structures were elucidated by spectroscopic and chemical analyses. Lonijaposide C (3) showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor.
Song
Weixia
W
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.
Li
Shuai
S
Wang
Sujuan
S
Wu
Yan
Y
Zi
Jiachen
J
Gan
Maoluo
M
Zhang
Yanling
Y
Liu
Mingtao
M
Lin
Sheng
S
Yang
Yongchun
Y
Shi
Jiangong
J
D000818:Animals; D035264:Flowers / Q000737:chemistry; D005966:Glucuronidase / Q000187:drug effects / Q000378:metabolism; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031239:Lonicera / Q000737:chemistry*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
D039823:Iridoids; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; C530312:lonijaposide A; C530313:lonijaposide B; C530314:lonijaposide C; D005966:Glucuronidase