title: The effect of bolus administration of remifentanil on QTc interval during induction of sevoflurane anaesthesia.
abstract: Stimulation of the sympathetic nervous system associated with tracheal intubation causes corrected QT (QTc) interval prolongation. We postulated that the use of remifentanil during induction of anaesthesia might prevent this. Sixty unpremedicated, ASA grade 1 patients were selected and randomly allocated to receive either saline (group S), remifentanil 0.5 microg x kg(-1) (group R 0.5) or remifentanil 1.0 microg x kg(-1) (group R1.0) 1 min before laryngoscopy. The QTc interval was significantly prolonged immediately following intubation in group S and group R0.5, but it remained stable in group R1.0, compared with the QTc interval just before laryngoscopy. It is concluded that the administration of remifentanil 1.0 microg x kg(-1) before intubation can prevent the prolongation of the QTc interval associated with tracheal intubation during induction of anaesthesia with sevoflurane.
authors.affiliation: Department of Anaesthesiology and Pain Medicine & Anaesthesia and Pain Research Institute, Yonsei University of College of Medicine, Seoul, Korea.
authors.forename: T D
authors.initials: TD
authors.lastname: Kweon
authors.forename: S B
authors.initials: SB
authors.lastname: Nam
authors.forename: C H
authors.initials: CH
authors.lastname: Chang
authors.forename: M S
authors.initials: MS
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: C S
authors.initials: CS
authors.lastname: Shin
authors.forename: D B
authors.initials: DB
authors.lastname: June
authors.forename: D W
authors.initials: DW
authors.lastname: Han
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018685:Anesthetics, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects; D007828:Laryngoscopy / Q000009:adverse effects; D008133:Long QT Syndrome / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects; D000077208:Remifentanil; D000077149:Sevoflurane
chemical_list: D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D000077208:Remifentanil