[Platelet aggregation inhibition in acute coronary syndrome. Facts and expectations].
The current practice of platelet aggregation inhibition in acute coronary syndrome is reviewed. The specific dosing and its clinical usefulness of each medication are considered. The author is drawing attention to the fact, that the dosing scheme used in the early phase 3 trials may not have been optimal as proven in later trials. The hyporeactivity against both acetylsalicylic acid and clopidogrel treatment is existing and maybe called resistance. Its clinical importance in clinical outcomes is to be determined in later investigations. Because of the probable relationship between resistance and clinical outcomes the measurement of platelet reactivity by a reliable rapid bedside tool may be important in the future. Also the new platelet aggregation inhibitors under development are reviewed.
Keltai
Mátyás
M
Semmelweis Egyetem, Altalános Orvostudományi Kar, Kardiológiai Tanszék, Budapest Gottsegen György Országos Kardiológiai Intézet, Budapest. keltai@kardio.hu
D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage; D000077144:Clopidogrel; D004334:Drug Administration Schedule; D004351:Drug Resistance; D015507:Drugs, Investigational; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives
D015507:Drugs, Investigational; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin