title: Glycosides from the root of Iodes cirrhosa.
abstract: Seven new neolignan glycosides ( 1- 7), two arylglycerol glycosides ( 8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of Iodes cirrhosa. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Based on analysis of the NMR data of threo and erythro 8-4'-oxyneolignans and arylglycerols in different solvents, the validity of J 7,8 and Deltadelta C8-C7 values to distinguish threo and erythro derivatives was discussed. In the in vitro assays, compound 4 and liriodendrin ( 17) both showed activity against glutamate-induced PC12 cell damage at 10 (-5) M.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
authors.forename: Maoluo
authors.initials: M
authors.lastname: Gan
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Mingtao
authors.initials: M
authors.lastname: Liu
authors.forename: Weixia
authors.initials: W
authors.lastname: Song
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zi
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Fan
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Hu
authors.forename: Jiandong
authors.initials: J
authors.lastname: Sun
authors.forename: Naihong
authors.initials: N
authors.lastname: Chen
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D016716:PC12 Cells / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans; D018698:Glutamic Acid