title: Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Randomized, crossover design.
  
  
  METHODS
  Academic research center.
  
  
  METHODS
  Fifteen women with PCOS.
  
  
  METHODS
  We evaluated changes in T, sex hormone binding globulin (SHBG), DHEAS, cortisol, glucose, and insulin for 6 hours after a high-fat, Western meal (HIFAT) (62% fat, 24% carbohydrate, 1 g fiber) and an isocaloric low-fat, high-fiber meal (HIFIB) (6% fat, 81% carbohydrate, 27 g fiber).
  
  
  METHODS
  Change in T levels.
  
  
  RESULTS
  Testosterone decreased 27% within 2 hours after both meals. However, T remained below premeal values for 4 hours after the HIFIB meal and 6 hours after the HIFAT meal. Insulin was twofold higher for 2 hours after the HIFIB meal compared with the HIFAT meal. Glucose was higher for 1 hour after the HIFIB meal compared with the HIFAT meal. DHEAS decreased 8%-10% within 2-3 hours after both meals, then increased during the remainder of the study period. Cortisol decreased during the 6-hour period after both meals.
  
  
  CONCLUSIONS
  Diet plays a role in the regulation of T levels in women with PCOS. Further studies are needed to determine the role of diet composition in the treatment of PCOS.
authors.affiliation: The Huck Institutes of the Life Sciences, Hershey, Pennsylvania, USA.
authors.forename: Heather I
authors.initials: HI
authors.lastname: Katcher
authors.forename: Allen R
authors.initials: AR
authors.lastname: Kunselman
authors.forename: Romana
authors.initials: R
authors.lastname: Dmitrovic
authors.forename: Laurence M
authors.initials: LM
authors.lastname: Demers
authors.forename: Carol L
authors.initials: CL
authors.lastname: Gnatuk
authors.forename: Penny M
authors.initials: PM
authors.lastname: Kris-Etherton
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood* / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D018592:Cross-Over Studies; D004036:Diet, Atherogenic; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000494:pharmacology; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000032:analysis / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D019366:Western World; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D004041:Dietary Fats; D004043:Dietary Fiber; D006728:Hormones; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone