Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus.
OBJECTIVE
To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry.


METHODS
Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects.


RESULTS
Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus.


CONCLUSIONS
In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.
Ishii
Kazunari
K
Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Japan. kishii@hbhc.jp
Kawaguchi
Tetsuro
T
Shimada
Kenichi
K
Ohkawa
Shingo
S
Miyamoto
Naokazu
N
Kanda
Tomonori
T
Uemura
Takafumi
T
Yoshikawa
Toshiki
T
Mori
Etsuro
E
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D002421:Caudate Nucleus / Q000473:pathology; D002555:Cerebrospinal Fluid; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid / Q000473:pathology*; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D010296:Parietal Lobe / Q000473:pathology; D017410:Practice Guidelines as Topic; D013788:Thalamus / Q000473:pathology