Inappropriate gonadotropin secretion in polycystic ovary syndrome.
OBJECTIVE
To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS).


METHODS
Retrospective study.


METHODS
Academic tertiary center.


METHODS
A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251).


METHODS
None.


METHODS
Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS.


RESULTS
The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects.


CONCLUSIONS
The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.
Hsu
Ming-I
MI
Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan.
Liou
Tsan-Hon
TH
Liang
So-Jung
SJ
Su
Hung-Wen
HW
Wu
Chien-Hua
CH
Hsu
Chun-Sen
CS
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
D006062:Gonadotropins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone