title: In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds.
abstract: A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.
authors.affiliation: Department of Chemistry, Balikesir University Science & Art Faculty, Balikesir, Turkey.
authors.forename: Ismet
authors.initials: I
authors.lastname: Basaran
authors.forename: Selma
authors.initials: S
authors.lastname: Sinan
authors.forename: Umit
authors.initials: U
authors.lastname: Cakir
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bulut
authors.forename: Oktay
authors.initials: O
authors.lastname: Arslan
authors.forename: Ozen
authors.initials: O
authors.lastname: Ozensoy
mesh_terms: D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors*; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors*; D003374:Coumarins / Q000494:pharmacology*; D003600:Cytosol / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics
chemical_list: D003374:Coumarins; D004791:Enzyme Inhibitors; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II