title: Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus.
abstract: Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of patients with pemphigus. Common terms and end points of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. This consensus statement from the International Pemphigus Committee represents 2 years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.
authors.affiliation: Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia.
authors.forename: Dedee F
authors.initials: DF
authors.lastname: Murrell
authors.forename: Sarah
authors.initials: S
authors.lastname: Dick
authors.forename: A R
authors.initials: AR
authors.lastname: Ahmed
authors.forename: Masayuki
authors.initials: M
authors.lastname: Amagai
authors.forename: Maria A
authors.initials: MA
authors.lastname: Barnadas
authors.forename: Luca
authors.initials: L
authors.lastname: Borradori
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Bystryn
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cianchini
authors.forename: Luis
authors.initials: L
authors.lastname: Diaz
authors.forename: David
authors.initials: D
authors.lastname: Fivenson
authors.forename: Russell
authors.initials: R
authors.lastname: Hall
authors.forename: Karen E
authors.initials: KE
authors.lastname: Harman
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Michael
authors.initials: M
authors.lastname: Hertl
authors.forename: Nico
authors.initials: N
authors.lastname: Hunzelmann
authors.forename: Pilar
authors.initials: P
authors.lastname: Iranzo
authors.forename: Pascal
authors.initials: P
authors.lastname: Joly
authors.forename: Marcel F
authors.initials: MF
authors.lastname: Jonkman
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kitajima
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Korman
authors.forename: Linda K
authors.initials: LK
authors.lastname: Martin
authors.forename: Daniel
authors.initials: D
authors.lastname: Mimouni
authors.forename: Amit G
authors.initials: AG
authors.lastname: Pandya
authors.forename: Aimee S
authors.initials: AS
authors.lastname: Payne
authors.forename: David
authors.initials: D
authors.lastname: Rubenstein
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimizu
authors.forename: Animesh A
authors.initials: AA
authors.lastname: Sinha
authors.forename: David
authors.initials: D
authors.lastname: Sirois
authors.forename: Detlef
authors.initials: D
authors.lastname: Zillikens
authors.forename: Victoria P
authors.initials: VP
authors.lastname: Werth
mesh_terms: D006801:Humans; D010392:Pemphigus / Q000175:diagnosis* / Q000628:therapy*