title: p-tert-Butylcalix[8]arene-bonded silica monoliths for liquid chromatography.
abstract: Monolithic silica columns have inspired considerable research interests in the separation science because of their unique properties in permeability, mass transfer, efficiency and throughput. In this paper, a chemically p-tert-butylcalix[8]arene-bonded silica monolith was prepared as the promising candidate for versatile LC separations. Micrometer-sized macropores and nanometer-sized mesopores in this derivatized silica monolith reduce the diffusion path length and provide both low backpressure and high column efficiencies, leading to high-speed and high-throughput separations. Since p-tert-butylcalix[8]arene possesses a pi-donors cavity composed of benzene rings while polycyclic aromatic hydrocarbons, anthraquinones, phenol regio isomers and fullerenes are pi-systems with appreciable electron affinity, they may have a chance to get involved in forming host-guest inclusion complexes through non-covalent interactions, e.g. hydrophobic and pi-pi interactions. Compared with RP-18e, the prepared calixarene-bonded monolith exhibited better selectivity to molecules which contains more pi-electrons and more condensed cyclic moieties. The column efficiency was about 22,000 plates/m. The calixarene-bonded monolith also showed its good performances in separation of fullerenes and dihydropyridines, indicating a promising approach for purification of fullerenes with high purity from the carbon soot.
authors.affiliation: Laboratory of Analytical Chemistry for Life Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
authors.forename: Junfa
authors.initials: J
authors.lastname: Yin
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.forename: Gengliang
authors.initials: G
authors.lastname: Yang
authors.forename: Hailin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000880:Anthraquinones / Q000737:chemistry; D001554:Benzene / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D002853:Chromatography, Liquid; D004095:Dihydropyridines / Q000737:chemistry; D004583:Electrons; D037741:Fullerenes / Q000302:isolation & purification; D057927:Hydrophobic and Hydrophilic Interactions; D007536:Isomerism; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010539:Permeability; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D004095:Dihydropyridines; D037741:Fullerenes; D047250:Calixarenes; D012822:Silicon Dioxide; D001554:Benzene