title: Optimizing poly-L-lactic acid use.
abstract: Injectable devices are less invasive than surgical interventions for restoring youthful contours. Sculptra (Dermik Laboratories, Bridgewater, NJ, USA, a business of sanofi aventis U.S. LLC) contains poly-l-lactic acid (PLLA), which is thought to elicit in vivo collagen production around the injected implant, producing new volume gradually over time, and with effects lasting up to 2 years. Correct reconstitution and preparation of PLLA, as well as injection technique, are essential to ensure optimal outcomes and reduce adverse events. This article provides an overview of injectable devices, specifically focusing on PLLA in cosmetic application and optimal administration techniques to maximize efficacy and duration of effect.
authors.affiliation: Cranley Clinic, London, United Kingdom. cranleyuk@aol.com
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Lowe
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D003357:Cosmetic Techniques; D006801:Humans; D007279:Injections, Subcutaneous; D019344:Lactic Acid / Q000627:therapeutic use*; D011091:Polyesters; D011108:Polymers / Q000627:therapeutic use*; D015595:Skin Aging
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)