title: Changes of visual evoked potential induced by lateral geniculate nucleus kindling in rats.
abstract: OBJECTIVE
  The present study was undertaken to investigate the changes of visual evoked potential (VEP) induced by lateral geniculate nucleus (LGN) kindling in comparison with those induced by amygdala (AMG) and hippocampus (HPC) kindling in rats.
  
  
  METHODS
  Under pentobarbital anesthesia, the rats were fixed to a stereotaxic apparatus, and stainless steel electrodes were implanted into the LGN, AMG, HPC and the occipital cortex (OCOR). Bipolar stimulation was applied to the LGN, AMG or HPC every day until generalized seizure was obtained. VEP was recorded from the OCOR before the first day of electric stimulation (pre-kindled) and after the development of kindling (post-kindled).
  
  
  RESULTS
  After the development of LGN kindling, the amplitudes of early VEP components (P(1)-N(1) and N(1)-P(2)) were significantly augmented in comparison with those of pre-kindled rats. In addition, the duration of the photically evoked after-discharge burst (duration of VEP) was significantly prolonged by LGN kindling. On the other hand, in AMG and HPC kindling, no significant changes were observed in VEP between pre-kindled and post-kindled rats.
  
  
  CONCLUSIONS
  The changes of VEP observed in patients with photosensitive epilepsy are also demonstrated in animal study using LGN kindling.
authors.affiliation: Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Akinori
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Kenshi
authors.initials: K
authors.lastname: Takechi
authors.forename: Jun
authors.initials: J
authors.lastname: Ago
authors.forename: Naotaka
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Md Ashequr
authors.initials: MA
authors.lastname: Rahman
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000679:Amygdala / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005829:Geniculate Bodies / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques