[The relation of insulin resistance with the complications of diabetes mellitus type 2 and metabolic parameters].
The aim of our investigation was to study the relation of insulin resistance (IR) with the complications of diabetes mellitus type 2 (DM2) and metabolic parameters. 44 patients with DM2 (mean age - 49,1+/-8,7 years) have been investigated. The parameters of carbohydrate metabolism, HOMA-indices, parameters of lipid metabolism and blood pressure have been determined. I group consisted of 32 patients with high mean value of HOMA-IR (2,6+/-0,8), and II group - 12 patients with lower mean value of HOMA-IR (0,9+/-0,3). The IHD frequency was significantly lower in II group (OR=0,20 (0,40-0,95)); and sum of macrovascular complications was significantly frequent in I group, i.e. in patients with IR (OR=9,71 (1,12-84,30)). In patients with IR serum C-peptide, triglycerides, HDL-cholesterol levels, sistolic blood pressure, body mass index and waist circumference were significantly differed from analogous parameters of patients without IR. IR significantly impact on the development of macrovascular complications of DM2 and significantly worsen the parameters of carbohydrate and lipid metabolism, blood pressure and body mass. Therefore, we conclude that in addition to the good glycemic control the important goal of the treatment of DM2 is the reduction of insulin resistance (introduction of insulin sensitizing agents, physical activity, body mass reduction, the decrease of daily insulin injecting doses).
Lomtadze
I
I
Tbilisi State Medical University, Department of Endocrinology, Tbilisi, Georgia.
Virsaladze
D
D
Koplatadze
M
M
Mikashavidze
T
T
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged