Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity.
Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard (DCMU). The structure-activity relationships are discussed.
Musiol
Robert
R
Institute of Chemistry, University of Silesia, Szkolna 9, 40006 Katowice, Poland.
Tabak
Dominik
D
Niedbala
Halina
H
Podeszwa
Barbara
B
Jampilek
Josef
J
Kralova
Katarina
K
Dohnal
Jiri
J
Finster
Jacek
J
Mencel
Agnieszka
A
Polanski
Jaroslaw
J
D000577:Amides / Q000737:chemistry*; D048408:Chlorella vulgaris / Q000187:drug effects / Q000378:metabolism; D002734:Chlorophyll / Q000378:metabolism; D002736:Chloroplasts / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000737:chemistry; D015394:Molecular Structure; D010788:Photosynthesis; D018724:Spinacia oleracea / Q000187:drug effects; D013329:Structure-Activity Relationship
D000577:Amides; D006912:Hydroxyquinolines; D008055:Lipids; D002734:Chlorophyll