title: Aggressive transformation of a quiescent primary bone lymphoma simulating Paget's disease.
abstract: Primary multifocal osseous lymphoma is a rare and poorly recognized entity. Here, we present an instructive case of a young man who, six years after a local contusion of the left ankle, developed a painful polylobulated large soft tissue mass. This mass turned out to have arisen from the transformation of a centro follicular non-Hodgkin's lymphoma into a diffuse large B-cell lymphoma involving the calcaneus, talus, cuboid and navicular bones. The diagnostic difficulties as well as the implications of this aggressive transformation are highlighted here.
authors.affiliation: Services of Rheumatology, Hospital Universitario de la Princesa, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ibáñez
authors.forename: B
authors.initials: B
authors.lastname: Cortina
authors.forename: V
authors.initials: V
authors.lastname: Gómez
authors.forename: J M
authors.initials: JM
authors.lastname: Alvaro-Gracia
authors.forename: T
authors.initials: T
authors.lastname: Reina
authors.forename: S
authors.initials: S
authors.lastname: Castañeda
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D003937:Diagnosis, Differential; D005528:Foot; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D010001:Osteitis Deformans / Q000175:diagnosis*