title: Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: a review of resting-state fMRI studies.
abstract: Resting-state functional magnetic resonance imaging (fMRI), a promising technique for measuring brain activities during rest, has attracted much attention in the past few years. In this paper, we review recent progress on the study of Alzheimer's disease (AD) based on resting-state fMRI. First, we briefly introduce some AD-related studies from other groups. Then we describe our AD-related work in detail from three aspects: (1) alterations in regional homogeneity (ReHo) of the fMRI signal in the resting state, (2) altered patterns of functional connectivity from regions of interest and whole brain analyses, and (3) discriminative analyses based on classification features from resting-state fMRI data for differentiating AD patients from healthy elders. Finally, we summarize the main results and some prospects for future work.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Meng
authors.initials: M
authors.lastname: Liang
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001037:Aphasia; D015415:Biomarkers; D001931:Brain Mapping; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging
chemical_list: D015415:Biomarkers