title: Preoperative serum sex hormone-binding globulin as a predictive marker for extraprostatic extension of tumor in patients with clinically localized prostate cancer.
abstract: OBJECTIVE
  We investigated the relationships of serum sex hormone-binding globulin (SHBG) level with known prognostic factors for prostate cancer in men who received radical retropubic prostatectomy (RRP) for clinically localized prostate cancer.
  
  
  METHODS
  Preoperative serum levels of SHBG were analyzed in 288 consecutive patients who were scheduled to undergo RRP for clinically localized prostate cancer. We investigated the potential associations of preoperative serum SHBG level with various clinical and pathological factors. Accuracy of variables in predicting adverse pathological features was assessed via receiver operator characteristics (ROC) curves.
  
  
  RESULTS
  In univariate analysis, preoperative serum SHBG level was observed to be significantly associated with extraprostatic extension of a tumor (p=0.019) and with pathological Gleason score (p=0.001). In multivariate analysis, serum SHBG level (p=0.039) along with serum PSA (p<0.001) level, biopsy Gleason score (p<0.001), and clinical stage (p=0.004) was observed to be an independent predictor of the extraprostatic extension of prostate cancer. The area under ROC curve that demonstrated the performance of a multivariate logistic regression model (MLRM), which included serum SHBG level and other preoperative variables, in predicting extraprostatic extension of tumor was larger than that of MLRM without SHBG (0.797 vs. 0.758, p=0.121). Meanwhile, serum SHBG level was not observed to be significantly associated with pathological Gleason score in multivariate analysis (p=0.303).
  
  
  CONCLUSIONS
  Our data showed that serum SHBG level is an independent predictive factor for extraprostatic extension of tumor in patients with clinically localized prostate cancer.
authors.affiliation: Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Sang Eun
authors.initials: SE
authors.lastname: Lee
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Chung
authors.forename: Byung Kyu
authors.initials: BK
authors.lastname: Han
authors.forename: Chan Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Ki Hyuk
authors.initials: KH
authors.lastname: Moon
authors.forename: Seok-Soo
authors.initials: SS
authors.lastname: Byun
authors.forename: Gheeyoung
authors.initials: G
authors.lastname: Choe
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Hong
mesh_terms: D000368:Aged; D000728:Androgens / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*
chemical_list: D000728:Androgens; D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin