title: [Age-related changes of albumin and actin of human myocardium].
abstract: In the human myocardium tissue, proteomic technologies revealed the products of 2 genes (alpha-actin and albumin), existing as fragments; their appearance and increased contents correlated with age. The age-related variants differ from the mature forms by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-dependent proteins were found in 50% of cases (in the age group 31-40 years), while in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the cardiac muscle and also of the adaptation-dysadaptations mechanisms in the CIHD.
authors.forename: M A
authors.initials: MA
authors.lastname: Kovaleva
authors.forename: L I
authors.initials: LI
authors.lastname: Kovalev
authors.forename: M V
authors.initials: MV
authors.lastname: Serebriakova
authors.forename: S A
authors.initials: SA
authors.lastname: Moshkovskiĭ
authors.forename: S S
authors.initials: SS
authors.lastname: Shishkin
mesh_terms: D000199:Actins / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000418:Albumins / Q000378:metabolism*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D040901:Proteomics
chemical_list: D000199:Actins; D000418:Albumins