Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells.
We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.
Ito
Hideyuki
H
Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima, Okayama 700-8530, Japan. hito@cc.okayama-u.ac.jp
Sun
Xiu-Lan
XL
Watanabe
Makiko
M
Okamoto
Motoi
M
Hatano
Tsutomu
T
D000818:Animals; D002392:Catechin / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000166:cytology; D044950:Flavanones / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology* / Q000196:embryology; D016501:Neurites / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D010636:Phenols / Q000494:pharmacology; D059808:Polyphenols; D051381:Rats; D017207:Rats, Sprague-Dawley
D003373:Coumaric Acids; D044950:Flavanones; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D002726:Chlorogenic Acid; D002392:Catechin; C028610:flavanone