title: Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions.
abstract: MICs and fractional inhibitory concentrations were evaluated for anidulafungin and voriconazole alone and in combination against conidia and hyphae under hypoxic (1% oxygen-5% CO(2)-94% nitrogen) conditions against 31 Aspergillus isolates. Anidulafungin exhibited excellent activity against conidia and hyphae of Aspergillus spp. The visual reading of the MIC for anidulafungin was optimal under hypoxic conditions.
authors.affiliation: Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. Susanne.Perkhofer@i-med.ac.at
authors.forename: Susanne
authors.initials: S
authors.lastname: Perkhofer
authors.forename: Daniel
authors.initials: D
authors.lastname: Jost
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Dierich
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
mesh_terms: D000693:Anaerobiosis; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects*; D001232:Aspergillus fumigatus / Q000187:drug effects; D004357:Drug Synergism; D054714:Echinocandins / Q000494:pharmacology*; D025301:Hyphae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D011743:Pyrimidines; D014230:Triazoles; D000077612:Anidulafungin; D065819:Voriconazole