Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.
The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.
Bowen
David G
DG
Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, 700 Childrens Dr., Columbus, OH 43205, USA.
Shoukry
Naglaa H
NH
Grakoui
Arash
A
Fuller
Michael J
MJ
Cawthon
Andrew G
AG
Dong
Christine
C
Hasselschwert
Dana L
DL
Brasky
Kathleen M
KM
Freeman
Gordon J
GJ
Seth
Nilufer P
NP
Wucherpfennig
Kai W
KW
Houghton
Michael
M
Walker
Christopher M
CM
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005434:Flow Cytometry; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D002679:Pan troglodytes
D000945:Antigens, Differentiation, T-Lymphocyte