"Click-fluors": modular fluorescent saccharide sensors based on a 1,2,3-triazole ring.
A carbohydrate sensing "click-fluor" is reported which displays a nontypical binding preference with sample saccharides. That a fluorescent sensor is generated as a result of triazole formation (click reaction), rather than simply bringing the sensor and reporter units together via a triazole linkage, and the potential applicability of the wide range of easily accessible acetylene units means a simple strategy for the development of modular fluorescent sensor arrays for rapid screening of target saccharides will be available.
Scrafton
David K
DK
Department of Chemistry, The University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Taylor
James E
JE
Mahon
Mary F
MF
Fossey
John S
JS
James
Tony D
TD
D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
D001897:Boronic Acids; D002241:Carbohydrates; D005456:Fluorescent Dyes; D014230:Triazoles