title: [Recent understanding of sepsis: mechanisms of organ dysfunction and advances in treatment --preface and comments].
abstract: This special issue focuses on recent advances in understanding pathogenesis and altered physiology of sepsis on cellular and molecular basis. It is recognized that remarkable advances have been made in understanding the basic cellular and molecular mechanisms of multiple organ dysfunction associated with sepsis. The rationale for therapeutic targets in sepsis has arisen from the concept of pathogenesis. Although a lot of clinical trials have been conducted, a small number of treatment or management protocols have been proven to be effective in severe sepsis. Although critical questions remain unanswered, these new insights into sepsis-associated mechanisms are likely to lead to effective treatment approaches that ultimately improve clinical outcome.
authors.affiliation: Department of Anesthesiology, The Graduate School of Medicine The University of Tokyo, Tokyo 113-8655.
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D018390:Gene Targeting; D006801:Humans; D018836:Inflammation Mediators; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy; D018805:Sepsis / Q000209:etiology / Q000628:therapy; D015398:Signal Transduction; D051193:Toll-Like Receptors
chemical_list: D018836:Inflammation Mediators; D051193:Toll-Like Receptors