title: Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy.
abstract: OBJECTIVE
  The objective of this study is to evaluate the efficiency of SOD applied topically in oncologic patients affected by acute radiodermatitis.
  
  
  METHODS
  This study includes 57 patients who showed a dermatitis grade 2 or superior; they were administered SOD ointment b.i.d. (40 mg, weekly) and follow-up continued for 12 weeks.
  
  
  RESULTS
  At the end of radiotherapy, 77.1% of the patients ameliorated completely or partially, and at the end of the 12-week period 100% of patients were free of toxicity. No acute toxicity relapses were reported. Response time reduced during radiotherapy, as well as the treatment time at the end of it.
  
  
  CONCLUSIONS
  The employment of SOD topically is efficient in the treatment of radiodermatitis, which is an acute side effect of radiotherapy.
authors.affiliation: Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Manzanas García
authors.forename: María Concepción
authors.initials: MC
authors.lastname: López Carrizosa
authors.forename: Carmen
authors.initials: C
authors.lastname: Vallejo Ocaña
authors.forename: Pilar
authors.initials: P
authors.lastname: Samper Ots
authors.forename: José María
authors.initials: JM
authors.lastname: Delgado Pérez
authors.forename: Emilia
authors.initials: E
authors.lastname: Carretero Accame
authors.forename: Pilar
authors.initials: P
authors.lastname: Gómez-Serranillos
authors.forename: Luis
authors.initials: L
authors.lastname: de la Morena del Valle
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D009824:Ointments; D011855:Radiodermatitis / Q000188:drug therapy* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D012867:Skin / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D009824:Ointments; D013482:Superoxide Dismutase