title: Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI.
abstract: We report a case of adenocarcinoma of the head of the pancreas, occult at extracellular contrast enhanced MDCT and magnetic resonance imaging (MRI), which was detected by MRI only with the use of a tissue-specific contrast agent (Mangafodipir trisodium Mn- DPDP). The histological examination after duodenopancreatectomy confirmed the diagnosis. Contrast-enhanced multi-detector computed tomography (MDCT) is currently considered to be the reference method for diagnosing and staging of pancreatic adenocarcinoma. Endoscopic Ultrasounds (EUS) with fine needle aspiration (FNA) is an accurate but invasive procedure. The technological evolution of magnetic resonance imaging and the development of organ-specific contrast media for liver and pancreas have led to a progressively more extensive use of this method for the investigation of suspected lesions. Moreover, this technique is particularly useful when MDCT gives unclear or debatable diagnostic responses.
authors.affiliation: Section of Radiological Sciences, Department of Clinical Sciences, University Hospital of Parma, Parma, Italy. massimo.defilippo@unipr.it
authors.forename: Massimo
authors.initials: M
authors.lastname: De Filippo
authors.forename: Carlo
authors.initials: C
authors.lastname: Bocchi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Quartieri
authors.forename: Domenico
authors.initials: D
authors.lastname: Corradi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zompatori
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid