title: Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women.
abstract: OBJECTIVE
  The aim of the present study was to clarify the association of serum adiponectin concentrations with serum 17beta-estradiol concentrations in pre-, peri-, and postmenopausal women. In addition, the associations of serum adiponectin with serum concentrations of proinflammatory and anti-inflammatory cytokines were examined in women during the menopausal transition.
  
  
  METHODS
  A total of 197 women were enrolled in this study: 33 premenopausal women, 80 perimenopausal women, and 84 postmenopausal women. Serum adiponectin concentration was measured by an enzyme-linked immunosorbent assay. Serum concentrations of the proinflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha, anti-inflammatory cytokine IL-10, and the chemokines IL-8, macrophage inflammatory protein-1beta and monocyte chemotactic protein-1 were measured by using a multiplexed human cytokine assay.
  
  
  RESULTS
  Serum adiponectin concentration showed a significant negative correlation with serum estradiol concentration (r= -0.400, P=0.001) in postmenopausal women but not in pre- and perimenopausal women, and this correlation was significant after adjustment for age and body mass index. Serum adiponectin concentration also showed a significant negative correlation with serum monocyte chemotactic protein-1 concentration (r= -0.244, P=0.05) in postmenopausal women.
  
  
  CONCLUSIONS
  An increase in adiponectin level due to a decrease in estradiol results in a reduction in monocyte chemotactic protein-1 level in postmenopausal women, suggesting that adiponectin may be associated with a protective role against insulin resistance and atherosclerosis, which occur in the postmenopausal stage.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Miyatani
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.forename: Masayo
authors.initials: M
authors.lastname: Yamada
authors.forename: Toshiya
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Akira
authors.initials: A
authors.lastname: Kuwahara
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yuzurihara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kase
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000097:blood*; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D017697:Premenopause / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016207:Cytokines; D004958:Estradiol