title: An approximate numerical technique for characterizing optical pulse propagation in inhomogeneous biological tissue.
abstract: An approximate numerical technique for modeling optical pulse propagation through weakly scattering biological tissue is developed by solving the photon transport equation in biological tissue that includes varying refractive index and varying scattering/absorption coefficients. The proposed technique involves first tracing the ray paths defined by the refractive index profile of the medium by solving the eikonal equation using a Runge-Kutta integration algorithm. The photon transport equation is solved only along these ray paths, minimizing the overall computational burden of the resulting algorithm. The main advantage of the current algorithm is that it enables to discretise the pulse propagation space adaptively by taking optical depth into account. Therefore, computational efficiency can be increased without compromising the accuracy of the algorithm.
authors.affiliation: Advanced Computing and Simulation Laboratory (AXL), Department of Electrical and Computer Systems Engineering, Monash University, Clayton, 3800 VIC, Australia. chintha.handapangoda@eng.monash.edu.au
authors.forename: Chintha C
authors.initials: CC
authors.lastname: Handapangoda
authors.forename: Malin
authors.initials: M
authors.lastname: Premaratne
mesh_terms: D000818:Animals; D016880:Anisotropy; D003198:Computer Simulation; D003238:Connective Tissue / Q000502:physiology*; D006801:Humans; D008027:Light; D008954:Models, Biological; D012031:Refractometry / Q000379:methods*; D012542:Scattering, Radiation