A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers.
Recurrent aphthous ulcers (RAU) are a common and painful condition. This article describes a randomized, double-blind clinical trial of an over-the-counter medicated intraoral adhesive patch for treatment of RAU. Subjects were randomly assigned to either an active drug (patch with extract of glycyrrhiza root) or placebo patch treatment group (both n=23) at onset of a lesion. Lesion size and pain report (unstimulated and stimulated) were assessed at intervals. A no-treatment group (n=23) also was recruited and assessed similarly. By the eighth day, the ulcer size for the active treatment group was significantly lower (p < 0.05), while the By the fourth day, the active treatment group lesions in the no-treatment group increased 13% from baseline.reported significantly less pre-stimulus pain (p < 0.01); at this point, 81% of this group reported no pre-stimulus pain, comp ared with 63% of the placebo patch group and 40% of the no-treatment group
Martin
Michael D
MD
University of Washington, Seattle, USA.
Sherman
Jefrey
J
van der Ven
Peter
P
Burgess
Jeffrey
J
D000287:Administration, Topical; D000293:Adolescent; D000704:Analysis of Variance; D047070:Bandages, Hydrocolloid; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D006035:Glycyrrhiza; D006801:Humans; D004366:Nonprescription Drugs / Q000627:therapeutic use; D010146:Pain / Q000150:complications / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D013281:Stomatitis, Aphthous / Q000150:complications / Q000188:drug therapy*
D004366:Nonprescription Drugs; D010936:Plant Extracts