title: Prenatal programming of renal function: the estimated glomerular filtration rate is influenced by size at birth in apparently healthy children.
abstract: Prenatal growth is known to affect glomerular function in adult life. It is unknown, however, whether this association is also present in children. In a cross-sectional study, we examined whether birth weight (BW) is associated with serum creatinine (measured by an improved Jaffe method) and GFR (estimated by the Haycock-Schwartz formula; eGFR) in 73 apparently healthy school-age children (35 boys and 38 girls; age 9.5 +/- 0.4 yr). All children were born after singleton term pregnancies (gestational age 39.6 +/- 0.2 wk) with normal BW (3.2 +/- 0.04 kg). A significant decrease in serum creatinine and increase in the eGFR was evident by tertiles of BW-SD score (SDS) (p = 0.001 and p < 0.0001). eGFR was correlated with BW-SDS (r = 0.45; p < 0.0001), so that each unit increase in BW-SDS was associated with an increase in eGFR of 10 (95% CI 5-14) ml/min per 1.73 m. In summary, estimates of glomerular function are in apparently healthy school-age children influenced by size at birth. These findings suggest early effects for the prenatal programming of renal function in humans.
authors.affiliation: Department of Pediatric Endocrinology, Dr. Josep Trueta Hospital, Girona 17007, Spain. uden.alopez@htrueta.scs.es
authors.forename: Abel
authors.initials: A
authors.lastname: López-Bermejo
authors.forename: Carmen
authors.initials: C
authors.lastname: Sitjar
authors.forename: Alicia
authors.initials: A
authors.lastname: Cabacas
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vázquez-Ruíz
authors.forename: Maria Mar
authors.initials: MM
authors.lastname: García-González
authors.forename: Carme
authors.initials: C
authors.lastname: Mora
authors.forename: Pilar
authors.initials: P
authors.lastname: Soriano
authors.forename: Mar
authors.initials: M
authors.lastname: Calvo
authors.forename: Lourdes
authors.initials: L
authors.lastname: Ibáñez
mesh_terms: D001724:Birth Weight; D002648:Child; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D047109:Fetal Development; D005865:Gestational Age; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000196:embryology / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D012016:Reference Values; D013030:Spain
chemical_list: D003404:Creatinine