Filling a GAP(DH) in asymmetric viral RNA synthesis.
Host proteins, such as RNA-binding proteins, are involved in most steps of replication by positive-strand RNA viruses, including Tomato bushy stunt virus (TBSV). In this issue of Cell Host & Microbe, Wang and Nagy report that efficient replication of TBSV requires GAPDH, a host protein with glycolytic, RNA-binding, and other functions. GAPDH binds TBSV (-)RNA and promotes the normal excess of (+)RNA over (-)RNA products, possibly by selectively retaining (-)RNA templates for copying.
Wang
Xiaofeng
X
Institute for Molecular Virology, University of Wisconsin, Madison, WI 53706, USA.
Ahlquist
Paul
P
D010940:Plant Proteins / Q000378:metabolism*; D012367:RNA, Viral / Q000096:biosynthesis*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D017864:Tombusvirus / Q000502:physiology*; D014779:Virus Replication
D010940:Plant Proteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins