title: Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals.
abstract: The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).
authors.affiliation: Dipartimento di Scienze Fisiche, Università di Napoli Federico II, Via Cinthia, 80126, Naples, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Autiero
authors.forename: Rosanna
authors.initials: R
authors.lastname: Cozzolino
authors.forename: Paolo
authors.initials: P
authors.lastname: Laccetti
authors.forename: Marcello
authors.initials: M
authors.lastname: Marotta
authors.forename: Maria
authors.initials: M
authors.lastname: Quarto
authors.forename: Patrizia
authors.initials: P
authors.lastname: Riccio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Roberti
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D055088:Early Detection of Cancer; D006415:Hematoporphyrins; D006801:Humans; D007091:Image Processing, Computer-Assisted; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D017319:Photosensitizing Agents; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology; D013050:Spectrometry, Fluorescence
chemical_list: D006415:Hematoporphyrins; D017319:Photosensitizing Agents