Contraception in hereditary angioedema.
OBJECTIVE
To report a case of successful use of a transdermal contraceptive in a patient with hereditary angioedema.


METHODS
Case report.


METHODS
University medical center.


METHODS
A patient who had used oral contraceptives contracted SC and submucosal tumefaction every 1 or 2 months. She was diagnosed with type I hereditary angioedema. It was determined that she was complement C4 deficient and C1-inhibitor quantitative deficient but functional C1-inhibitor normal. After she was diagnosed, the use of oral contraceptives was contraindicated.


METHODS
Oral contraceptives were suspended, and a hormonal transdermal contraceptive was started.


METHODS
The absence of symptoms after 26 months using a transdermal contraceptive.


RESULTS
After 26 months of using this treatment, the patient has not experienced any symptoms of the hereditary angioedema.


CONCLUSIONS
The use of hormonal contraceptives transdermally can be an alternative in patients with hereditary angioedema.
Sanhueza
Pablo I
PI
Obstetrics and Gynaecology Department, Health Sciences Faculty, School of Medicine, Andres Bello University, Santiago, Chile. pab.sanhueza@uandresbello.edu
D000279:Administration, Cutaneous; D054179:Angioedemas, Hereditary / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009644:Norgestrel / Q000008:administration & dosage / Q000031:analogs & derivatives*
D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; C511292:Ortho Evra; D009644:Norgestrel; D004997:Ethinyl Estradiol