Synthesis and applications of shell cross-linked thermoresponsive hybrid micelles based on poly(N-isopropylacrylamide-co-3-(trimethoxysilyl)propyl methacrylate)-b-poly(methyl methacrylate).
Shell cross-linked (SCL) thermoresponsive hybrid micelles consisting of a cross-linked thermoresponsive hybrid hydrophilic shell and a hydrophobic core domain were synthesized from poly(N-isopropylacrylamide-co-3- (trimethoxysilyl)propyl methacrylate)-b-polymethyl methacrylate (P(NIPAAm-co-MPMA)-b-PMMA) amphiphilic block copolymers. Transmission electron microscopy (TEM) images showed that the SCL micelles formed regularly globular nanoparticles. The SCL micelles showed reversible dispersion/aggregation in response to temperature cycles through an outer polymer shell lower critical solution temperature (LCST) for PNIPAAm at around 33 degrees C, observed by turbidity measurements and dynamic light scattering (DLS). The drug loading and in vitro drug release properties of the SCL micelles bearing a silica-reinforced PNIPAAm shell were further studied, which showed that the SCL micelles exhibited a much improved entrapment efficiency (EE) as well as a slower release rate which allowed the entrapped molecules to be slowly released over a much longer period of time as compared with pure PNIPAAm-b-PMMA micelles.
Wei
Hua
H
Department of Chemistry & Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072, PR China.
Cheng
Cheng
C
Chang
Cong
C
Chen
Wen-Qin
WQ
Cheng
Si-Xue
SX
Zhang
Xian-Zheng
XZ
Zhuo
Ren-Xi
RX
D000085:Acetates / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry*; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size; D011241:Prednisone / Q000737:chemistry; D013696:Temperature
D000085:Acetates; D000178:Acrylamides; D003432:Cross-Linking Reagents; D008689:Methacrylates; D008823:Micelles; D017646:Organosilicon Compounds; C509363:poly(N-isopropylacrylamide-b-methyl methacrylate); C505504:3-(trimethoxysilyl)propyl methacrylate; D011241:Prednisone