title: First-line treatment of advanced gastric cancer and hepatic dysfunction with oxaliplatin, 5-fluorouracil and cetuximab.
abstract: There is no standard chemotherapy regimen in advanced gastric cancer with poor performance status and hepatic dysfunction. New chemotherapeutical agents and targeted therapy have demonstrated promising results in terms of efficacy and safety in phase II clinical trials. We report the case of a 68-year-old man with stage IV gastric cancer and severe hepatic dysfunction due to liver metastases treated with a combination of oxaliplatin, 5-fluorouracil and cetuximab.
authors.affiliation: Servicio de Oncología Médica, Hospital General Universitario Gregorio Marañón, Madrid, Spain. ajmunoz.hgugm@salud.madrid.org
authors.forename: Andrés Jesús
authors.initials: AJ
authors.lastname: Muñoz Martín
authors.forename: Virginia
authors.initials: V
authors.lastname: Martínez Marín
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Arranz Cózar
authors.forename: Luis
authors.initials: L
authors.lastname: Cabezón Gutiérrez
authors.forename: Ricardo
authors.initials: R
authors.lastname: González del Val Subirats
authors.forename: Pilar
authors.initials: P
authors.lastname: García Alfonso
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068818:Cetuximab; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000068818:Cetuximab; D005472:Fluorouracil