[Spreading and mechanisms of antimicrobial resistance of microorganisms, producing beta-lactamases. Phenotypical screening for MBL producers (carbapenemases B1) among strains of Pseudomonas genus, isolated in cases of nosocomial infections].
Intrahospital strains (215) of the bacterial genus Pseudomonas isolated from patients of 30 Medical centers of 15 Russian regions have been investigated for antibiotic resistance. The bacterial cultures resistant to imipenem and/or meropenem were considered as metallo-beta-lactamase (MBL) producers. Production of subclass B1 MBL (carbapenemases) was evaluated by means of the double-disk approximation test using MBL inhibitor, EDTA. There were 55 P. aeroginosa strains (25.6%) resistant to imipenem and meropenem simultaneously; 19 isolates (8.8%) of P. aeroginosa were characterized by synergism between carbapenem and EDTA. The subclass B1 MBL producers are widely distributed in the intrahospital strain obtained from Moscow, Yaroslavl, Ekaterinburg, Omsk, and Tomsk hospitals.
Ivanov
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Egorov
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D000900:Anti-Bacterial Agents / Q000819:agonists / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002614:Chelating Agents / Q000494:pharmacology; D003428:Cross Infection / Q000188:drug therapy / Q000201:enzymology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D015378:Imipenem / Q000819:agonists / Q000494:pharmacology; D000077731:Meropenem; D011549:Pseudomonas / Q000201:enzymology*; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000201:enzymology*; D013845:Thienamycins / Q000819:agonists / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002614:Chelating Agents; D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D015378:Imipenem; D004492:Edetic Acid; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem