Polymorph control: past, present and future.
The appearance and disappearance of polymorphs is no longer a mysterious and inexplicable process. Although methods for polymorph control are still imperfect, there is a large armoury of methods that can be used to tackle this important and challenging problem. We survey the methods and their successes over the last few years.
Llinàs
Antonio
A
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom. Antonio.Llinas@ch.cam.ac.uk
Goodman
Jonathan M
JM
D003460:Crystallization / Q000379:methods* / Q000639:trends*; D006801:Humans; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D013816:Thermodynamics; D014961:X-Ray Diffraction
D004364:Pharmaceutical Preparations; D012997:Solvents