Biologically active tetralones from New Caledonian Zygogynum spp.
Bioassay guided purification of the ethyl acetate extracts of the bark and leaves of five New Caledonian Zygogynum species (Winteraceae) led to the isolation and characterization of four phenyl-3-tetralones (3,4-dihydronaphthalen-1(2H)-one). Their structures were determined by various NMR techniques and chemical studies. The absolute configuration of the compounds was established by circular dichroism. The compounds showed binding affinity for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and significant inhibitory activity against KB cancer cell line.
Allouche
Noureddine
N
Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.
Morleo
Barbara
B
Thoison
Odile
O
Dumontet
Vincent
V
Nosjean
Olivier
O
Guéritte
Françoise
F
Sévenet
Thierry
T
Litaudon
Marc
M
D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009510:New Caledonia; D047495:PPAR gamma / Q000187:drug effects; D035261:Plant Components, Aerial; D044024:Tetralones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D032423:Winteraceae / Q000737:chemistry*
D047495:PPAR gamma; D044024:Tetralones; C531206:zygolone A