title: Cytotoxic diterpenoids from Euphorbia helioscopia.
abstract: Four new jatrophane-type diterpenoids (1-4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1-4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa and MDA-MB-231 cells was evaluated, with only helioscopinolide A (5) and euphornin (3a) being active.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang, Shanghai, PR China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: Xing-Nuo
authors.initials: XN
authors.lastname: Li
authors.forename: Guang-Tong
authors.initials: GT
authors.lastname: Chen
authors.forename: Jin-Qiang
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Hui-Lian
authors.initials: HL
authors.lastname: Huang
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D045784:Abietanes / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C530235:euphornin; C487257:helioscopinolide A