title: Sex dimorphism in the outcome of preoperative right portal vein embolization.
abstract: OBJECTIVE
  Although studies indicate that patient sex modulates the process of hepatic regeneration, it remains unknown whether sex has a role in the outcome of preoperative right portal vein embolization (PVE). We analyzed the effects of patient sex on the outcome of right PVE followed by major hepatectomy.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Academic research.
  
  
  METHODS
  Eighty-eight patients (42 men and 46 women) who underwent preoperative right PVE for bile duct carcinoma were analyzed retrospectively.
  
  
  METHODS
  The percentage liver volume change, the plasma indocyanine green clearance rate, and the rate of postoperative hepatic failure were compared between men and women.
  
  
  RESULTS
  The mean (SD) volume of the nonembolized lobe after PVE in women (323 [61] mL/m(2)) was statistically significantly greater than that in men (287 [61] mL/m(2)) (P =.008). The mean (SD) ratio of the nonembolized lobe to the total liver volume was also statistically significantly greater in women (45.8% [5.8%]) than in men (42.0% [5.9%]) (P =.003). The mean (SD) indocyanine green clearance rate of the future liver remnant was 0.075 [0.014] in women and 0.056 [0.011] in men (P =.001). The incidence of postoperative hepatic failure was higher in men (12 of 42 [28.6%]) than in women (8 of 46 [17.4%]) (P =.16).
  
  
  CONCLUSIONS
  These results indicate that sex dimorphism can be present in the outcome of preoperative right PVE.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. yyoko@med.nagoya-u.ac.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Masato
authors.initials: M
authors.lastname: Nagino
authors.forename: Koji
authors.initials: K
authors.lastname: Oda
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishio
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ebata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Abe
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Igami
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nimura
mesh_terms: D000368:Aged; D001661:Biliary Tract Neoplasms / Q000601:surgery / Q000628:therapy*; D004396:Coloring Agents / Q000493:pharmacokinetics; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D017093:Liver Failure / Q000209:etiology; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011169:Portal Vein; D011300:Preoperative Care; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green