title: Severe liver disease in pregnancy.
abstract: OBJECTIVE
  To determine the clinical characteristics of patients with fulminant hepatitis of pregnancy (FHP) and acute fatty liver of pregnancy (AFLP) and analyze their correlation with pregnancy outcome.
  
  
  METHODS
  Of 55 pregnant women with severe liver disease, 41 had FHP and 14 had AFLP.
  
  
  RESULTS
  Jaundice was the primary manifestation for both FHP and AFLP and hepatic encephalopathy was the most significant complication for both. Disseminated intravascular coagulation, albuminuria, and prothrombin activity were found to be independent risk factors of maternal mortality for both. However, the rates of preterm labor, fetal demise, and neonatal asphyxia were lower in the FHP group.
  
  
  CONCLUSIONS
  Women with FHP or AFLP are at risk for severe complications and adverse pregnancy outcome. Since the 2 conditions are managed differently, early diagnosis is essential.
authors.affiliation: Obstetrics and Gynecology Department, The Second Affiliated Hospital of Sun Yat-Sen University, Guangdong, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.forename: Jianping
authors.initials: J
authors.lastname: Tan
authors.forename: Yukun
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D005234:Fatty Liver / Q000150:complications* / Q000401:mortality; D005260:Female; D005313:Fetal Death; D006501:Hepatic Encephalopathy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D008099:Liver / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000150:complications* / Q000401:mortality; D008428:Maternal Mortality; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000209:etiology*; D011256:Pregnancy Outcome; D012044:Regression Analysis; D012307:Risk Factors