[The clinical significance of serum tuberculosis specific antigen antibody in the diagnosis of tuberculosis].
OBJECTIVE
To evaluate the significance of serum tuberculosis specific antigen (TB-SA) antibody detection in the diagnosis of tuberculosis.


METHODS
TB-SA antibody in the serum samples from 829 cases of tuberculosis, 278 patients with non-tuberculosis lung diseases and 125 healthy volunteers were detected using enzyme-linked immunosorbent assay (ELISA). Tuberculosis was confirmed by clinical, bacteriology, X-ray examination and pathology studies.


RESULTS
The sensitivity of TB-SA antibody in diagnosis of bacteriologically positive and negative pulmonary tuberculosis and extrapulmonary tuberculosis was 75.1% (272/362), 68.9% (226/328) and 71.2% (99/139), respectively; the combined sensitivity was 72.0% (597/829), and the specificity 82.1% (331/403). The relationship between the OD(405) of TB-SA antibody and PPD positivity showed no linear relationship, suggesting that BCG vaccination did not affect the value of serum TB-SA antibody.


CONCLUSIONS
The results suggest that measurement of serum TB-SA is a relatively sensitive and specific method for the diagnosis and differential diagnosis of tuberculosis.
Gao
Meng-Qiu
MQ
Department of Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Chu
Nai-Hui
NH
Wang
Hai-Ying
HY
Zhao
Qing-Rong
QR
Li
Hua
H
Gao
Xu-Sheng
XS
Luo
Tao
T
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013183:Sputum / Q000382:microbiology; D014374:Tuberculin Test; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D055815:Young Adult
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D011933:Reagent Kits, Diagnostic