title: Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma.
abstract: OBJECTIVE
  Distinguishing between malignant and benign biliary strictures remains problematic. The aim of this study was to compare and contrast the clinical features of patients with benign and malignant biliary strictures.
  
  
  METHODS
  Medical records of patients who underwent surgical resection for presumed cholangiocarcinoma were reviewed. Immunohistochemistry for hypoxia inducible factor-1-alpha (HIF-1-alpha) was performed on all bile ductule samples.
  
  
  RESULTS
  Twelve patients with benign strictures (group I) were compared to 26 patients with cholangiocarcinoma (group II). Group I was predominantly female (ratio 2: 1), (p<0.01), whereas the gender ratio was 1: 1 in patients in group II. Bismuth-Corlette type strictures in group I were more likely to be type I/II, whereas type III strictures predominated in group II. The CA 19-9 was <100 U/ml in 6 and >100 U/ml in 1 patient of group I and <100 in 13 and >100 in 11 patients in group II. Half of the patients in group I had positive immunoreactivity for HIF-1-alpha in bile ductules.
  
  
  CONCLUSIONS
  Benign biliary strictures masquerading as cholangiocarcinomas occur more often in women, are less often Bismuth-Corlette type III, have serum CA 19-9 values <100 U/ml, and hypoxia may play a role in a subset of these strictures.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. gores.gregory@mayo.edu
authors.forename: E S
authors.initials: ES
authors.lastname: Baskin-Bey
authors.forename: H C
authors.initials: HC
authors.lastname: Devarbhavi
authors.forename: D M
authors.initials: DM
authors.lastname: Nagorney
authors.forename: M B
authors.initials: MB
authors.lastname: Farnell
authors.forename: J H
authors.initials: JH
authors.lastname: Donohue
authors.forename: S O
authors.initials: SO
authors.lastname: Sanderson
authors.forename: L M
authors.initials: LM
authors.lastname: Stadheim
authors.forename: G J
authors.initials: GJ
authors.lastname: Gores