title: [Identification of metastasis-associated proteins of ovarian cancer by proteomics].
abstract: OBJECTIVE
  To investigate the differenal protein expression profiles of ovarian tumor cell lines with distinct metastatic abilities.
  
  
  METHODS
  The ovarian cancer cell line HO8910 and HO8910pm, derived from same parental cells but exhibited different metastatic ability, were investigated by two-dimensional gel electrophoresis (2-DE)-MALDI-TOF-MS proteomic approach.
  
  
  RESULTS
  Thirty-nine proteins were detected by 2-DE to have expression disparity levels over 2 folds between two cell lines. Eighteen of them were identified by MALDI-TOF-MS. The proteins are involved in apoptosis, extra cellular matrix (ECM), cytoskeleton, growth factor, glycolysis, protein metabolism and immune system.
  
  
  CONCLUSIONS
  The data are valuable for the identification of differentially expressed proteins involved in the biological behavior of human ovarian cancer.
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of National Administration of Education, Institute for Cancer Research, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying-Tao
authors.initials: YT
authors.lastname: Zhang
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Geng
authors.forename: Lü-Sheng
authors.initials: LS
authors.lastname: Si
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization