In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon.
Esenbeckia febrifuga (Rutaceae) is a plant traditionally used to treat malaria in the Brazilian Amazon region. Ethanol extract of stems displayed a good antiplasmodial activity against Plasmodium falciparum strains W-2 (IC(50) 15.5+/-0.71 microg/ml) and 3 D7 (IC(50) 21.0+/-1.4 microg/ml). Two coumarins (bergaptene 1 and isopimpinellin 2), five alkaloids (flindersiamine 3, kokusaginine 4, skimmiamine 5, gamma-fagarine 6 and 1-hydroxy-3-methoxy-N-methylacridone, 7), besides a limonoid (rutaevine 8), have been isolated for the first time from this species. Antiplasmodial activity of compounds 3, 5-8 has been evaluated in vitro against P. falciparum strains (W-2 and 3D7) and the furoquinolines 5 and 6 were the most potent displaying IC(50) values <50 microg/ml; flindersiamine (3) showed a weak activity while alkaloid 7 and rutaevine (8) were inactive (IC(50)>100 microg/ml).
Dolabela
Maria Fâni
MF
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil.
Oliveira
Salma G
SG
Nascimento
José Maria
JM
Peres
José Maria
JM
Wagner
Hildebert
H
Póvoa
Marinete Marins
MM
de Oliveira
Alaíde Braga
AB
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D001938:Brazil; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D004912:Erythrocytes / Q000469:parasitology; D000431:Ethanol / Q000737:chemistry; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008519:Medicine, Traditional; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D010963:Plasmodium falciparum / Q000187:drug effects*; D027821:Rutaceae / Q000737:chemistry*
D000962:Antimalarials; D010936:Plant Extracts; D000431:Ethanol; D002738:Chloroquine