title: Effect of lornoxicam on postoperative analgesia after myomectomy.
abstract: BACKGROUND
  In this prospective, randomized study, we evaluate the postoperative analgesic effect of lornoxicam after myomectomy operations.
  
  
  METHODS
  Forty ASA I-II patients scheduled for myomectomy operation were enrolled to this study. Patients were randomly divided into two groups and epidural block was performed with 0,75 % ropivacaine. After the operation, morphine Patient Controlled Epidural Analgesia (PCEA) combined with placebo (saline 2 ml iv) and morphine PCEA combined with lornoxicam 8 mg iv were administered to patients in Group I and Group II, respectively. Pain was assessed at the 0,1st, 2nd, 4th, 6th, 8th, 12th and 24th hours postoperatively. Chi-square and student's t tests were used for statistical analysis.
  
  
  RESULTS
  VAS( Visual Analog Scale) scores were higher in Group I than Group II at 2nd, 4th, 6th and 24th hours. Total morphine consumption was 10.45+/- 4.03 in Group I and 4.25 +/- 1.74 in Group II.
  
  
  CONCLUSIONS
  Single dose iv lornoxicam is a safe and an effective treatment option of post-myomectomy pain as it produces effective analgesia, reduces morphine consumption and does not increase the side effects.
authors.affiliation: Department of Anesthesiology and Reanimation, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey. namikayse@yahoo.com
authors.forename: Ipek
authors.initials: I
authors.lastname: Erdoğan
authors.forename: Türkay
authors.initials: T
authors.lastname: Cakan
authors.forename: Ayşe
authors.initials: A
authors.lastname: Ozcan
authors.forename: Esra
authors.initials: E
authors.lastname: Türkyilmaz
authors.forename: Bülent
authors.initials: B
authors.lastname: Baltaci
authors.forename: Bayazit
authors.initials: B
authors.lastname: Dikmen
mesh_terms: D000577:Amides / Q000627:therapeutic use*; D000698:Analgesia / Q000379:methods*; D016058:Analgesia, Patient-Controlled / Q000379:methods; D000767:Anesthesia, Epidural / Q000379:methods; D000779:Anesthetics, Local / Q000627:therapeutic use*; D006801:Humans; D009020:Morphine / Q000627:therapeutic use; D009214:Myoma / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010919:Placebos; D000077212:Ropivacaine; D013997:Time Factors
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D010919:Placebos; D010894:Piroxicam; D009020:Morphine; D000077212:Ropivacaine; C059451:lornoxicam