Discovery of tight junction modulators: significance for drug development and delivery.
Tight junction biology has many important applications, from improving knowledge of diseases characterized by the loss of epithelial or endothelial tissue barrier function to providing a mechanistic basis for improving non-invasive drug delivery. A variety of chemical and molecular biological tools have been developed, including high throughput cell-based screening of molecular libraries that facilitate discovery of novel peptides and lipids to modulate tight junction function safely and reversibly. Further development of novel tight junction modulating excipients necessitates consideration of physicochemical, toxicological, pharmaceutical and regulatory issues.
Johnson
Paul H
PH
Nastech Pharmaceutical Company, Inc., 3830 Monte Villa Parkway, Bothell, WA 98021, USA.
Frank
Diane
D
Costantino
Henry R
HR
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D016503:Drug Delivery Systems; D015195:Drug Design; D004705:Endocytosis; D004848:Epithelium / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction; D019108:Tight Junctions / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
D010455:Peptides