title: HCV non-structural protein 3 and HCV RNA genome in non-Hodgkin lymphoma and transition of the serum HCV RNA level: a retrospective analysis in one institution.
abstract: There have been various reports on the association of hepatitis C virus (HCV) infection with B lymphocyte proliferative disorders, such as non-Hodgkin lymphoma (NHL). We experienced a case (Case 1) of anti-HCV antibody (HCV-Ab)-positive NHL in which HCV nonstructural protein 3 (NS3) expression was observed in lymphoma tissue at the time of recurrence and in which the serum HCV RNA level exhibited a transient increase prior to recurrence. We investigated the HCV RNA genome in lymphoma tissue in Case 1, and it could be detected at recurrence. We also investigated HCV NS3 protein expression in lymphoma tissue and changes in serum HCV RNA level during the clinical course in four other cases of HCV-Ab-positive NHL treated in our hospital. We examined lymphoma tissues for HCV NS3 protein expression in four of the five cases, but it was not identified except for in Case 1 at recurrence. In three cases with no recurrence, serum HCV RNA levels showed a tendency to decrease after completion of chemotherapy and became stable thereafter. Further studies are necessary to clarify the association between serum HCV RNA and the onset and exacerbation of NHL.
authors.affiliation: Department of Internal Medicine, Hakodate Municipal Hospital, 1-10-1, Hakodate, 041-8680, Japan. Sohichi.Shiratori@ma6.seikyou.ne.jp
authors.forename: Souichi
authors.initials: S
authors.lastname: Shiratori
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Takahito
authors.initials: T
authors.lastname: Kawamura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kudo
authors.forename: Norihiko
authors.initials: N
authors.lastname: Shimoyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Masauzi
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016174:Hepacivirus; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000821:virology*; D012367:RNA, Viral / Q000097:blood*; D012189:Retrospective Studies; D017361:Viral Nonstructural Proteins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases