title: Identification and characterization of mouse type II platelet-derived growth factor receptor alpha transcript.
abstract: Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor alpha mRNA (type II) that differs from the known human PDGF receptor alpha mRNA (type I) only in its 5'-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor alpha mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.
authors.affiliation: Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Minato
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nihei
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kodama
authors.forename: Etsu
authors.initials: E
authors.lastname: Tashiro
authors.forename: Mai
authors.initials: M
authors.lastname: Kanai
authors.forename: Masaya
authors.initials: M
authors.lastname: Imoto
mesh_terms: D000818:Animals; D001483:Base Sequence; D050687:E2F1 Transcription Factor / Q000502:physiology*; D004622:Embryo, Mammalian; D005786:Gene Expression Regulation; D051379:Mice; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics* / Q000302:isolation & purification; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D020218:Response Elements; D014158:Transcription, Genetic
chemical_list: D050687:E2F1 Transcription Factor; C493754:E2f1 protein, mouse; D012333:RNA, Messenger; D020796:Receptor, Platelet-Derived Growth Factor alpha