Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.
Akhmanova
Anna
A
Department of Cell Biology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands. a.akhmanova@erasmusmc.nl
Steinmetz
Michel O
MO
D000818:Animals; D016764:Cell Polarity; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000737:chemistry* / Q000378:metabolism*
D008869:Microtubule-Associated Proteins