title: The management of oral mucous membrane pemphigoid with dapsone and topical corticosteroid.
abstract: BACKGROUND
  Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial disease that primarily affects the mucous membranes of patients over the age of 50 years, resulting in mucosal ulceration and subsequent scarring.
  
  
  OBJECTIVE
  The purpose of this study was to investigate the efficacy of dapsone in combination with topical corticosteroids to treat the oral lesions of MMP.
  
  
  METHODS
  Twenty-two patients who had been diagnosed with MMP were selected. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of four groups according to his or her response to therapy.
  
  
  RESULTS
  Five patients with mild to moderate disease were treated with topical corticosteroids alone for the duration of the study; 15 patients with moderate to severe disease were treated by topical corticosteroid with dapsone therapy. All of 15 patients had significant benefits.
  
  
  CONCLUSIONS
  The use of dapsone in combination with topical corticosteroids is one of the most useful methods for the treatment of MMP.
authors.affiliation: Department of Oral Medicine, Faculty of Dentistry, Ahwaz University of Medical Sciences, Ahwaz, Iran. drarashazizi@yahoo.com
authors.forename: Azizi
authors.initials: A
authors.lastname: Arash
authors.forename: Lawaf
authors.initials: L
authors.lastname: Shirin
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003622:Dapsone / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000188:drug therapy*; D010391:Pemphigoid, Bullous / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D005938:Glucocorticoids; D003622:Dapsone