[Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer].
OBJECTIVE
To investigate the association between the CTLA-4 promoter-1722(T/C) and 3' untranslated region CT60(G/A) polymorphisms and the risk of breast cancer in Han women of northeast China.


METHODS
328 patients with breast cancer and 327 healthy people as control were genotyped for -1722 and CT60 polymorphism using polymerase chain reaction and restriction fragment length polymorphism.


RESULTS
The frequency of the G allele at the CT60 site in breast cancer patients was statistically higher than that in control(28.7% vs 23.5%, P=0.0352, OR=1.30, 95% CI=1.02-1.67). The frequency of -1722C-CT60A haplotype in control was significantly higher than that in breast cancer patients(P=0.0283, OR=0.77, 95% CI=0.97-0.61). However, the distribution of genotypes at -1722 site was not significantly different between breast cancer patients and control.


CONCLUSIONS
The polymorphism of -1722T/C and CT60G/A may be related to the development of breast cancer in Han women of northern China.
Li
Heng
H
Department of Immunology, Harbin Medical University, Harbin 150081, China. 0213liheng@sina.com
Fu
Zhen-kun
ZK
Wang
Li-hong
LH
Li
Da-lin
DL
Wu
Na
N
Zhang
Jie
J
Li
Dian-jun
DJ
D000328:Adult; D000368:Aged; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics* / Q000502:physiology; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D060908:CTLA-4 Antigen; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human