[Physiopathology of cystic fibrosis and of infections associated to this disease].
Cystic fibrosis (CF) is one of the most common lethal inherited diseases in the caucasian population. The hope of understanding the physiopathology of CF appeared after identification of the gene which encodes CF. The alteration in CFTR protein breaks the hydric balance of the mucosal secretions, producing mucus with increased viscosity. Broncho-pulmonary infections are constant encountered because of the stasis of the mucus. The most common bacterial pathogens in the sputum of patients with MV are Haemophilus influenzae, Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia. MV remains a severe, incurable disease, but the evolution is getting better because of the improvements of care methods.
Aramă
Stefan Sorin
SS
Catedra de Patologie Generală şi Oromaxilofacială, Facultatea de Medicină Dentară, UMF Carol Davila Bucureşti. sorinarama@gmail.com
Aramă
Victoria
V
Cercel
Adrian Streinu
AS
Ion
Daniela Adriana
DA
Hristea
Adriana
A
Sotcan
Mihai
M
D001996:Bronchopneumonia / Q000382:microbiology / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology*; D006192:Haemophilus Infections / Q000382:microbiology / Q000503:physiopathology; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D018410:Pneumonia, Bacterial / Q000382:microbiology* / Q000503:physiopathology*; D011552:Pseudomonas Infections / Q000382:microbiology / Q000503:physiopathology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013183:Sputum / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology / Q000503:physiopathology; D013211:Staphylococcus aureus / Q000302:isolation & purification