One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of alpha-bromoacetate, malononitrile and aromatic aldehydes.
Polysubstituted benzene derivatives with an unprecedented substitution pattern are produced in a novel one-pot multi-component cyclization reaction from pyridine, ethyl alpha-bromoacetate, malononitrile and aromatic aldehyde in refluxing acetonitrile.
Yan
Chao Guo
CG
College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China. cgyan@yzu.edu.cn
Song
Xiao Kai
XK
Wang
Qi Fang
QF
Sun
Jing
J
Siemeling
Ulrich
U
Bruhn
Clemens
C
D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000447:Aldehydes; D001555:Benzene Derivatives; D009570:Nitriles; C016274:bromoacetate; C000945:dicyanmethane