Biochemical and white blood cell profiles of baboon neonates consuming formulas with moderate and high dietary long-chain polyunsaturated fatty acids.
BACKGROUND
Clinical chemistry and complete blood count (CBC) values were determined in 14 term baboons (Papio species) consuming formula with moderate or high levels of dietary long-chain polyunsaturated fatty acids (LCPUFA) from 2-12 weeks of age.


METHODS
Neonates were randomized to three groups: C: Control, no LCPUFA; L: 0.33% docosahexaenoic acid (DHA)/0.67% arachidonic acid (ARA) (w/w); L3:1.00% DHA/0.67% ARA (w/w). Blood chemistries were assessed at 6 and 12 weeks and CBC parameters were measured at 2, 4, 8, 10, 12 weeks of age.


RESULTS
Dietary LCPUFA had significant effects on serum triglyceride (C > L,L3) and calcium (L > C,L3). No other significant effects of diet were detected; pooled values are presented for all other parameters.


CONCLUSIONS
These data provide longitudinal biochemical and white cell/platelet/immunological data on LCPUFA-fed baboons over the first 12 weeks of life. Data ranges are similar to reference data in cases for which values exist and hematological changes reflect trends observed during human neonatal development.
Hsieh
A T
AT
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Anthony
J C
JC
Diersen-Schade
D A
DA
Nathanielsz
P W
PW
Brenna
J Thomas
JT
D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D001774:Blood Chemical Analysis / Q000662:veterinary*; D002118:Calcium / Q000097:blood; D004032:Diet / Q000662:veterinary; D004041:Dietary Fats / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D041943:Infant Formula / Q000737:chemistry; D007958:Leukocyte Count / Q000662:veterinary*; D010215:Papio / Q000097:blood*; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; D002118:Calcium