Linear assemblies of magnetic nanoparticles as MRI contrast agents.
Using a one-step procedure we have prepared magnetic fluids comprising of polyelectrolyte stabilized magnetite nanoparticles. These nanocomposites are comprised of linear, chain-like assemblies of magnetic nanoparticles, which can be aligned in parallel arrays by an external magnetic field. We have shown the potential use of these materials as contrast agents by measuring their MR response in live rats. The new magnetic fluids have demonstrated good biocompatibility and potential for in vivo MRI diagnostics.
Corr
Serena A
SA
School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland.
Byrne
Stephen J
SJ
Tekoriute
Renata
R
Meledandri
Carla J
CJ
Brougham
Dermot F
DF
Lynch
Marina
M
Kerskens
Christian
C
O'Dwyer
Laurence
L
Gun'ko
Yurii K
YK
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000737:chemistry; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects; D007501:Iron / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008280:Magnetics; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D014867:Water / Q000737:chemistry
D003287:Contrast Media; D004573:Electrolytes; D011137:Polystyrenes; D014867:Water; C003321:polystyrene sulfonic acid; D007501:Iron