title: Aspirin resistance is more common in lacunar strokes than embolic strokes and is related to stroke severity.
abstract: The aim of this study was to investigate the relationship between aspirin resistance, ischaemic stroke subtype, stroke severity, and inflammatory cytokines. Aspirin resistance was assessed by thrombelastography in 45 people with ischaemic stroke and 25 controls. Plasma interleukin (IL)-6 was measured. Stroke severity was assessed using the modified Rankin scale and National Institute of Health Stroke Score within 72 h of stroke. Aspirin resistance was more common in the stroke than the control group (67% versus 40%, P=0.028), and within the stroke group the aspirin-resistant group had a higher Rankin score (4.0 versus 2.0, P=0.013). Aspirin resistance was greater in lacunar than embolic strokes (platelet activation 79% versus 59%, P=0.020). The stroke aspirin-resistant group had higher levels of IL-6 than the stroke aspirin-sensitive group (2.4+/-1 versus 1.8+/-0.9 ng/mL, P=0.037). Using multivariate analysis, we examined the interrelationships between aspirin resistance, IL-6, and stroke severity. These analyses showed that IL-6 was independently associated with stroke severity as the outcome (B=3.738, P=0.036), and aspirin resistance was independently associated with IL-6 (B=0.765, P=0.005) as the outcome. In conclusion, aspirin resistance is related to stroke severity and aspirin resistance is more common in lacunar strokes than embolic strokes.
authors.affiliation: Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK. nae@soton.ac.uk
authors.forename: Nicola A
authors.initials: NA
authors.lastname: Englyst
authors.forename: Gill
authors.initials: G
authors.lastname: Horsfield
authors.forename: Joseph
authors.initials: J
authors.lastname: Kwan
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Byrne
mesh_terms: D000368:Aged; D001241:Aspirin / Q000494:pharmacology*; D020520:Brain Infarction / Q000473:pathology*; D004351:Drug Resistance / Q000187:drug effects*; D004617:Embolism / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D015539:Platelet Activation / Q000187:drug effects; D020521:Stroke / Q000097:blood / Q000473:pathology*
chemical_list: D015850:Interleukin-6; D001241:Aspirin