The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study.
OBJECTIVE
The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women.


METHODS
Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment.


RESULTS
Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin.


CONCLUSIONS
Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.
Gulhan
Ibrahim
I
Departments of Obstetrics and Gynecology, Izmir Training and Research Hospital, Izmir, Turkey. drigulhan@yahoo.com
Bilgili
Sibel
S
Gunaydin
Rezzan
R
Gulhan
Sibel
S
Posaci
Cemal
C
D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000188:drug therapy; D011446:Prospective Studies; D013876:Thiophenes / Q000494:pharmacology* / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D020738:Leptin; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D015675:Osteocalcin; D007334:Insulin-Like Growth Factor I