Social support and enhanced suppression of adrenocorticotropic hormone and cortisol responses to hypothalamic-pituitary-adrenal function and thyrotropin-releasing hormone tests in patients with major depressive disorder.
The results of the thyrotropin-releasing hormone (TRH) stimulation test and the combined dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are believed to correlate with social support status in patients with major depressive disorder. We studied 41 consecutive patients hospitalized for major depressive disorder and tested their responses to DEX/CRH and TRH on hospital days 4-7. DeltaMAX TSH and DeltaMAX cortisol were measured. Multiple regression analysis found that social support questionnaire (SSQ-A) and SSQ-B scores were significantly related to DeltaMAX cortisol and DeltaMAX TSH, respectively, at the time of admission. Social support might contribute partially to the TRH and DEX/CRH test results in patients with major depressive disorder.
Tsuru
Jusen
J
Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Oita 879-5593, Japan.
Akiyoshi
Jotaro
J
Tanaka
Yoshihiro
Y
Matsushita
Hirotaka
H
Hanada
Hiroaki
H
Kodama
Kensuke
K
Hikichi
Takatoshi
T
Ohgami
Hirochika
H
Tsutsumi
Takashi
T
Isogawa
Koichi
K
Nagayama
Haruo
H
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003346:Corticotropin-Releasing Hormone; D003865:Major Depressive Disorder / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism*; D011446:Prospective Studies; D012044:Regression Analysis; D012189:Retrospective Studies; D012944:Social Support; D011795:Surveys and Questionnaires
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone