title: [Cocaine-induced brain stem stroke associated to craneal midline destructive lesions].
abstract: BACKGROUND
  Abuse of cocaine and other sympathomimetic drugs has been reported as a significant risk factor for stroke. The physiopathologic mechanisms implicated are multifactorial. Chronic cocaine use leads to extensive destruction of osteocartilaginous structures of nose, sinuses and palate.
  
  
  METHODS
  We report the case of a 56 years-old woman with hypertension and smoke abuse who was admitted with a pontine paramedian infarction. Cranial resonance findings of midline destructive lesions lead to the suspicion of chronic cocaine consumption. The initial outcome was good but she was re-admitted nine months later with an extent pontomesencephalic infarction.
  
  
  CONCLUSIONS
  Abuse of cocaine is a risk factor for stroke that should be considered not only in young patients. The pathogenic relationship between stroke and midline cocaine related destructive lesions is discussed.
authors: Servicios de Neurología. Hospital de Navarra, Pamplona, Spain. bzanamo@hotmail.com
authors: B
authors: B
authors: Zandio Amorena
authors: M E
authors: ME
authors: Erro Aguirre
authors: T
authors: T
authors: Cabada
authors: T
authors: T
authors: Ayuso Blanco
mesh_terms: D020526:Brain Stem Infarctions / Q000139:chemically induced*; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology*; D011149:Pons / Q000473:pathology
chemical_list: D003042:Cocaine