Typical and atypical pulmonary carcinoids: our institutional experience.
Pulmonary carcinoids are rare malignant neoplasms, accounting for 2-5% of all lung tumors, with an approximate annual incidence of 2.3-2.8 cases per million of the population. We relate our experience of 54 patients (21 male, 33 female, mean age 53+/-15 years) treated between July 1986 and April 2006. All the patients underwent preoperative fibrobronchoscopy: preoperative diagnosis was made in 28 patients (52%). Surgical treatment consisted of: 31 standard lobectomies, 6 pneumonectomies, 5 bilobectomies, 2 sleeve lobectomies, 2 anatomic segmentectomies, 6 wedge resections; two patients were managed with sleeve bronchial procedure of the left main bronchus without lung resection. Fifty-four patients were followed with a mean time of observation of 67 months: 6 (11%) deaths occurred, at a mean period of 49 months after surgery; there were no postoperative deaths. Overall, 5-year survival was 91%, 10 years 83%: 5-year survival was 91% for typical carcoinoids (TC) vs. 88% for atypical (AC), 10 years 91% for TC and 44% for AC (significant value, P=0.0487). Carcinoid tumors are a distinct group of neuroendocrine tumors with a good prognosis in most cases. Surgery currently represents the best treatment with good results at mid- and long-term survival, according to an acceptable risk.
Bini
Alessandro
A
Department of Thoracic Surgery, University of Bologna, S. Orsola-Malpighi Hospital, Via Massarenti, 9, 40138 Bologna (BO), Italy.
Brandolini
Jury
J
Cassanelli
Nicola
N
Davoli
Fabio
F
Dolci
Giampiero
G
Sellitri
Francesco
F
Stella
Franco
F
D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D001999:Bronchoscopy / Q000379:methods; D002276:Carcinoid Tumor / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005336:Fiber Optic Technology; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy; D013997:Time Factors; D016896:Treatment Outcome