title: Methotrexate rechallenge following delayed clearance and life-threatening toxicity.
abstract: Life-threatening toxicity is often a contraindication for cytotoxic treatment. Many childhood malignancies have good outcomes with appropriate aggressive chemotherapy. It is not easy to decide whether to subject a child with a good prognostic tumor to a drug that has previously caused significant toxicity. One such situation is documented in this report.
authors: Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK.
authors: Parameswaran
authors: P
authors: Anoop
authors: Sucheta J
authors: SJ
authors: Vaidya
authors: Julie
authors: J
authors: Mycroft
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D008727:Methotrexate