Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole.
We demonstrate that incorporation of MnSalen into a protein scaffold enhances the chemoselectivity in sulfoxidation of thioanisole and find that both the polarity and hydrogen bonding of the protein scaffold play an important role in tuning the chemoselectivity.
Zhang
Jun-Long
JL
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Garner
Dewain K
DK
Liang
Lei
L
Chen
Qian
Q
Lu
Yi
Y
D002614:Chelating Agents / Q000737:chemistry; D003067:Coenzymes / Q000737:chemistry*; D003198:Computer Simulation; D005029:Ethylenediamines / Q000737:chemistry; D006860:Hydrogen Bonding; D008345:Manganese / Q000737:chemistry*; D045726:Metalloproteases / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015202:Protein Engineering; D013379:Substrate Specificity; D013440:Sulfides / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*
D002614:Chelating Agents; D003067:Coenzymes; D005029:Ethylenediamines; D009942:Organometallic Compounds; D013440:Sulfides; D013454:Sulfoxides; D008345:Manganese; C011452:disalicylaldehyde ethylenediamine; C093850:methylphenylsulfide; D045726:Metalloproteases