title: [The functional status of the human stomach in the course of the experiment with antiorthostatic hypokinesia of 4 months duration].
abstract: The paper deals with type of changes in gastroduodenal organs associated with hypersecretion of the stomach induced by simulation of some effects of microgravity. Subjects in the investigation were 13 males volunteered for a 4-month bedrest study. Biochemical changes in blood, urine and gastric juices were analyzed in comparison with ultrasonic images of the gastroduodenum organs and data of stomach and duodenum endoscopy. The investigations showed increased blood and urine levels of pepsinogen indicative of gastric hypersecretion characterized by more intensive secretion of gastric juices, lowered pH, elevated pyloric tone, activation of duodenal secretion and cholepoiesis. Gastric hypersecretion was concomittant to the development of plethora in the abdominal veins. The highest gastric secretion was observed after two months of bed rest. Further bed rest extension was marked by fading of the signs of hypersecretion by the stomach and appearance of some signs of chronic stress. Our results expand the knowledge of changes in the gastroduodenal organs during bed rest, space flights and other conditions provocative of the hypersecretory transformation of the stomach.
authors: B V
authors: BV
authors: Afonin
authors: N P
authors: NP
authors: Goncharova
authors: Iu A
authors: IuA
authors: Karamyshev
mesh_terms: D000328:Adult; D001510:Bed Rest; D004384:Duodenoscopy; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005773:Gastroscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018476:Hypokinesia / Q000503:physiopathology*; D008297:Male; D010434:Pepsin A / Q000097:blood / Q000378:metabolism; D020116:Pepsinogen A / Q000097:blood / Q000652:urine; D013270:Stomach / Q000503:physiopathology*; D013997:Time Factors; D014893:Weightlessness
chemical_list: D020116:Pepsinogen A; D010434:Pepsin A