Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis.
OBJECTIVE
To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA.


METHODS
This is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F,10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA).


RESULTS
Median adjusted height (AHt) SDS was -0.3 (-2.2 to 1.6). Serum ALS SDS (median -1.3, range -2.7 to -0.6) was reduced compared with serum IGFBP-3 SDS (median -0.5, range -7.7 to 2.3) and IGF-1 SDS (median -0.2, range -0.5 to 0.5). Log serum IL5 (95% CI -3.25, -0.81) and log serum IL15 (95% CI -9.58, -4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS.


CONCLUSIONS
Children with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.
Wong
S C
SC
Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, United Kingdom.
MacRae
V E
VE
Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, United Kingdom; Bone Biology Group, Roslin Institute, Roslin, United Kingdom.
Gracie
J A
JA
Centre for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom.
McInnes
I B
IB
Centre for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom.
Galea
P
P
Department of Child Health, University of Glasgow, Glasgow, United Kingdom.
Gardner-Medwin
J
J
Department of Child Health, University of Glasgow, Glasgow, United Kingdom.
Ahmed
S F
SF
Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, United Kingdom.
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood* / Q000276:immunology; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006130:Growth Disorders / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015848:Interleukin-5 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011446:Prospective Studies; D011627:Puberty
D016207:Cytokines; C508599:IL5 protein, human; C508600:IL6 protein, human; D018969:Insulin-Like Growth Factor Binding Proteins; D015848:Interleukin-5; D015850:Interleukin-6; D007334:Insulin-Like Growth Factor I