The RNA coregulator SRA, its binding proteins and nuclear receptor signaling activity.
Nuclear receptor (NR) coregulators are key modulators of hormone signaling. Discovery of steroid receptor RNA activator (SRA), a coregulator that is active as a RNA, transformed thinking in the field of hormone action. The subsequent identification of SRA-binding coregulator proteins, including p68, SHARP and more recently SLIRP, has provided important insight into SRA's mechanism of action and potentially offers new opportunities to target NR signaling pathways for therapeutic gain. Here we outline advances in the field of NR coregulator biology, with a bias on recent progress in understanding SRA-protein interactions.
Colley
Shane M
SM
Laboratory for Cancer Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, the University of Western Australia, WA, Australia.
Iyer
Kavitha R
KR
Leedman
Peter J
PJ
D000818:Animals; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D017570:MyoD Protein / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D009687:Nuclear Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; C512286:SLIRP protein, human; C476510:SPEN protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C405423:steroid receptor RNA activator; D012313:RNA