Hemodialysis using a valveless pulsatile blood pump.
Research on pulsatile blood pumps for extracorporeal life support has been widely performed because of the proven advantageous effects of blood pulsation. However, studies on the use of pulsatile blood pumps for hemodialysis are limited, although available evidence demonstrates that pulsatile blood flow has a positive influence on dialysis outcome. Therefore, the authors designed a new pulsatile pump, which is characterized by minimal-occlusion of blood-containing tubing, no requirement for valves, and no blood flow regurgitation. In-vitro hemolysis tests were conducted using fresh bovine blood, and the normalized index of hemolysis was adopted to compare blood traumas induced by the devised pulsatile pump and a conventional roller pump. In addition, experimental hemodialyses with a canine renal failure model were performed using the devised pump. Normalized index of hemolysis levels obtained was much smaller for the devised pulse pump (45 +/- 21 mg/100 L) than for the roller pump (103 +/- 10 mg/100 L), and no technical problems were encountered during dialysis sessions. Blood and dialysate flow rates were maintained at predetermined values and molecular removal was satisfactory. Postdialysis urea and creatinine reduction ratios were 61.8% +/- 10.6% and 57.4% +/- 9.0%, respectively. Pulsatile flow has usually been generated using pulsatile devices containing valves, but the valves cause concern in terms of the clinical applications of these devices. However, the described pulsatile pump does not require valves, and yet no blood flow regurgitation was observed.
Lee
Kyungsoo
K
Interdisciplinary Program in Biomedical Engineering, Seoul National University, Seoul, Korea.
Mun
Cho Hae
CH
Lee
Sa Ram
SR
Min
Byoung Goo
BG
Yoo
Kyu Jae
KJ
Park
Yong Woo
YW
Won
Yong Soon
YS
D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation* / Q000379:methods; D001783:Blood Flow Velocity; D002417:Cattle; D004285:Dogs; D004867:Equipment Design; D007676:Kidney Failure, Chronic / Q000628:therapy; D011673:Pulsatile Flow; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods