The role of autophagy during ischemia/reperfusion.
Ischemia (hypoxia)/reperfusion (I/R) primarily caused by atherosclerosis and thrombosis, induces tissue injury and organ malfunction, and is therefore, an important clinical problem. Understanding the cellular mechanisms of enhancing cell survival or preventing cell death during I/R could lead to development of strategies to treat this health problem.
Sadoshima
Junichi
J
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA. Sadoshju@umdnj.edu
D001343:Autophagy; D006801:Humans; D007511:Ischemia; D015424:Reperfusion; D015427:Reperfusion Injury; D015398:Signal Transduction