title: Bifunctional ligands based on the DOTA-monoamide cage.
abstract: Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.
authors: Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via Giuria, 9-10125, Torino, Italy.
authors: Alessandro
authors: A
authors: Barge
authors: Lorenzo
authors: L
authors: Tei
authors: Dharita
authors: D
authors: Upadhyaya
authors: Franco
authors: F
authors: Fedeli
authors: Lorena
authors: L
authors: Beltrami
authors: Rachele
authors: R
authors: Stefanìa
authors: Silvio
authors: S
authors: Aime
authors: Giancarlo
authors: G
authors: Cravotto
mesh_terms: D000577:Amides / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure
chemical_list: D000577:Amides; D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D008024:Ligands; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid