[The protein C system in chronic hepatic diseases, and anti-viral therapy].
The purpose of the investigation was to study the condition of the protein C system in chronic virial hepatitis (CVH) and viral hepatic cirrhosis (HC) during the course of antiviral therapy. The total protein C system activity (in a form of normalized ratio - NR) was studied before and 6 month after antiviral therapy in 27 patients with CVH B, in 79 patients with CVH C, and in 5 patients CVH D, as well in 29 patients with viral HC and 29 patients with alcoholic HC/. The total protein C system activity was decreased in chronic viral hepatic disease, and was minimal in patients with HC; the most severe disturbances were observed in patients with poor prognosis of HC and decompensated portal hypertension. The study found a correlation between NR values and histological manifestation of the pathology, which demonstrates an important role of the protein C system in the progress of chronic hepatic diseases. Anti-virial drugs had a positive effect of the functioning of the protein C system, which may be one of the ways of the realization of their antifibrotic effect.
Koroĭ
P V
PV
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011486:Protein C / Q000378:metabolism*; D012720:Severity of Illness Index
D000998:Antiviral Agents; D015415:Biomarkers; D011486:Protein C