title: Idiopathic tracheal stenosis: successful outcome with antigastroesophageal reflux disease therapy.
abstract: There is controversial evidence that gastroesophageal reflux disease (GERD) is an etiologic factor for idiopathic laryngotracheal stenosis. We present the case of a 44-year-old woman with symptomatic tracheal stenosis managed as idiopathic stenosis. She underwent six endoscopic dilations during 1 year, and before surgery she underwent 24-hour esophageal pH monitoring that documented GERD. Anti-GERD treatment was started, which was confirmed as effective with 24-hour esophageal pH monitoring 3 months later. At 2-year follow-up the patient remained free of symptoms and no additional airway procedure was necessary. A close relationship between anti-GERD therapy and clinical outcome was noted.
authors: Division of Thoracic Surgery, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil. rmterra@uol.com.br
authors: Ricardo Mingarini
authors: RM
authors: Terra
authors: Israel Lopes
authors: IL
authors: de Medeiros
authors: Hélio
authors: H
authors: Minamoto
authors: Ary
authors: A
authors: Nasi
authors: Paulo Manuel
authors: PM
authors: Pego-Fernandes
authors: Fábio Biscegli
authors: FB
authors: Jatene
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001707:Biopsy, Needle; D001999:Bronchoscopy / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004417:Dyspnea / Q000175:diagnosis / Q000209:etiology; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D050782:Esophageal pH Monitoring; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D009853:Omeprazole / Q000008:administration & dosage*; D012720:Severity of Illness Index; D014135:Tracheal Stenosis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D004791:Enzyme Inhibitors; D009853:Omeprazole