Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine-titanium complex.
The readily available and inexpensive new chiral oxazolidine in combination with Ti(O(i)Pr)(4) was found to catalyze the reaction of an alkynylzinc reagent with various types of aldehydes to generate chiral propargylic alcohols with high enantioselectivities (up to 95%) and excellent yields (up to 98%).
Xu
Zhou
Z
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou (Soochow) University, Suzhou, 215123, China.
Mao
Jincheng
J
Zhang
Yawen
Y