title: Review and clinical perspectives for the use of infliximab in ulcerative colitis.
abstract: Infliximab is a chimeric, monoclonal anti-tumour necrosis factor-alpha antibody. It has been previously demonstrated to be an effective treatment for patients with Crohn's disease who do not achieve the desired response with conventional treatments. Although the etiology of ulcerative colitis (UC) differs from that of Crohn's disease, randomized controlled trials have demonstrated that infliximab is also beneficial for the treatment of moderate to severe UC in patients who are either intolerant of or refractory to immunosuppressant agents or steroids, or those who are steroid-dependent. A review of the literature is followed by practical recommendations regarding infliximab that address the needs of clinicians and UC patients. Where there is a lack of evidence-based information, the expert panel provides its combined opinion derived from the members' clinical experiences.
authors: University of Calgary, Calgary, Canada.
authors: R
authors: R
authors: Panaccione
authors: R N
authors: RN
authors: Fedorak
authors: G
authors: G
authors: Aumais
authors: Edmond-Jean
authors: EJ
authors: Bernard
authors: C N
authors: CN
authors: Bernstein
authors: A
authors: A
authors: Bitton
authors: K
authors: K
authors: Croitoru
authors: L A
authors: LA
authors: Dieleman
authors: R
authors: R
authors: Enns
authors: B G
authors: BG
authors: Feagan
authors: D
authors: D
authors: Franchimont
authors: G R
authors: GR
authors: Greenberg
authors: Anne-Marie
authors: AM
authors: Griffiths
authors: J K
authors: JK
authors: Marshall
authors: P
authors: P
authors: Pare
authors: S
authors: S
authors: Patel
authors: R
authors: R
authors: Penner
authors: C
authors: C
authors: Render
authors: E
authors: E
authors: Seidman
authors: A Hillary
authors: AH
authors: Steinhart
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D000075202:Contraindications; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D018570:Risk Assessment
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab