title: Feasibility of routine lymphadenectomy in clinical stage-I endometrial cancer.
abstract: BACKGROUND
  To determine the accuracy of several preoperative tests in predicting lymph node (LN) metastases and the feasibility of doing a routine lymphadenectomy in clinical stage-I endometrial cancer.
  
  
  METHODS
  We reviewed 132 patients with clinical stage-I endometrial cancer. The preoperative tests used to predict LN metastases were serum CA-125 level, histologic type and grade, LN status assessed by pelvic magnetic resonance image (MRI) or computed tomography (CT), and depth of myometrial invasion assessed only by pelvic MRI. The cutoff value of the serum CA-125 level was determined using receiver operating characteristic curves. Multivariate logistic regression analyses were used to determine which tests are good predictors of LN metastases.
  
  
  RESULTS
  Of 132 patients, 13 (9.8%) had LN metastases. On univariate logistic regression analysis, a high CA-125 level and preoperative LN evaluation by pelvic MRI or CT were significant predictors for LN metastases (OR=17.41, 95% CI: 4.36-69.56 and OR=14.30, 95% CI: 4.02-50.63, respectively). However, on multivariate logistic regression analysis adjusted for age and all preoperative tests, a high CA-125 level was the most significant predictor (OR=13.73, 95% CI: 2.03-92.73). Among the 97 patients with no significant predictor of LN metastases, pelvic LN metastases were observed in 3 patients (3.1%) and para-aortic LN metastases were observed in 1 patient (1.1%). Surgical complications were mild (lymphocele, n=9; lymphedema, n=2; wound problem, n=2).
  
  
  CONCLUSIONS
  Considering the importance of LN metastases as an indicator of prognosis, and the relatively low surgical risk of lymphadenectomy, clinicians should cautiously consider routine lymphadenectomy in patients with clinical stage-I endometrial cancer.
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Jongno-Gu, Seoul, Korea.
authors: Seung-Su
authors: SS
authors: Han
authors: Jeong Yeon
authors: JY
authors: Cho
authors: In-Ae
authors: IA
authors: Park
authors: Sue Kyung
authors: SK
authors: Park
authors: Yong-Tark
authors: YT
authors: Jeon
authors: Jae Weon
authors: JW
authors: Kim
authors: Noh-Hyun
authors: NH
authors: Park
authors: Soon-Beom
authors: SB
authors: Kang
authors: Hyo-Pyo
authors: HP
authors: Lee
authors: Yong-Sang
authors: YS
authors: Song
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D016889:Endometrial Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D005189:False Positive Reactions; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor