Tissue factor, angiogenesis and tumour progression.
Tissue factor, the primary initiator of the coagulation cascade, maintains vascular integrity in response to injury. It is now recognised that, in addition to the role as a procoagulant activator, tissue factor participates in many tumour-related processes that contribute to malignant disease progression. The present review details the recent evidence supporting a role for tissue factor in tumour haemostasis, angiogenesis, metastasis and malignant cell survival. Furthermore, future research directions are discussed that may enhance our understanding of the role and regulation of this protein, which could ultimately lead to the innovative design and development of new anticancer therapies.
Bluff
Joanne E
JE
Microcirculation Research Group, Academic Unit of Surgical Oncology, School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK. j.bluff@sheffield.ac.uk
Brown
Nicola J
NJ
Reed
Malcolm W R
MW
Staton
Carolyn A
CA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002470:Cell Survival; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006487:Hemostasis; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*; D054556:Venous Thromboembolism / Q000139:chemically induced / Q000209:etiology*
D000970:Antineoplastic Agents; D013925:Thromboplastin