Reactive oxygen species and HIF-1 signalling in cancer.
The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumour initiation and progression. Malfunction of the HIF-1 signalling network has been associated with breast, ovarian and prostate cancers. Elevated reactive oxygen species (ROS), also observed in such tumours, have been implicated in HIF-1 signalling. Deciphering the role of ROS in cancer onset and their involvement in signalling networks should prove invaluable for the design of novel anticancer therapeutics.
Galanis
Alex
A
Laboratory of Gene Expression, Molecular Diagnosis and Modern Therapeutics, Department of Molecular Biology and Genetics, Democritus University of Thrace, Dimitras 19, 68100 Alexandroupolis, Greece.
Pappa
Aglaia
A
Giannakakis
Antonis
A
Lanitis
Evripidis
E
Dangaj
Denarda
D
Sandaltzopoulos
Raphael
R
D000818:Animals; D015687:Cell Hypoxia; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology*; D051379:Mice; D035683:MicroRNAs / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
D051793:Hypoxia-Inducible Factor 1; D035683:MicroRNAs; D017382:Reactive Oxygen Species