Severe digital ischemia-a presenting symptom of malignancy-associated antiphospholipid syndrome.
The association of the antiphospholipid syndrome with malignancy has been extensively reported. Raynaud's phenomenon has also been reported to be associated with various malignancies. In this report, we describe two patients who presented with severe digital ischemia mimicking Raynaud's phenomenon. The patients were found to have antiphospholipid syndrome, and upon extensive evaluation, a diagnosis of a malignancy was made. This report highlights the importance of malignancy workup in patients with severe digital ischemia associated with antiphospholipid syndrome.
Grossman
A
A
Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petach Tikva Israel. Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel. alon2206@012.net.il
Gafter-Gvili
A
A
Green
H
H
Ben Aharon
I
I
Stemmer
S M
SM
Molad
Y
Y
Krause
I
I
D000368:Aged; D016736:Antiphospholipid Syndrome / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D011928:Raynaud Disease / Q000209:etiology*