title: CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
authors: Menzies Research Institute, University of Tasmania, Tasmania, Australia.
authors: Bradley N
authors: BN
authors: Wray
authors: Jim
authors: J
authors: Stankovich
authors: Lucy
authors: L
authors: Whittock
authors: Terence
authors: T
authors: Dwyer
authors: Anne-Louise
authors: AL
authors: Ponsonby
authors: Ingrid A F
authors: IA
authors: van der Mei
authors: Bruce
authors: B
authors: Taylor
authors: Joanne
authors: J
authors: Dickinson
authors: Simon
authors: S
authors: Foote
authors: Brendan J
authors: BJ
authors: McMorran
mesh_terms: D015703:Antigens, CD / Q000235:genetics*; D001315:Australia / Q000453:epidemiology; D060908:CTLA-4 Antigen; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D006684:HLA-DR Antigens