[Comparative assessment of the strength properties of the mucous membrane of the stomach in patients with peptic ulcer and the effect of quamatel on ulcer cicatrization in experiment].
The article reviews the research work of the authors on the strength properties of the mucous membrane of the stomach in patients with peptic ulcer and in experiment with quamatel application. Experiments were performed in laboratory animals and resected stomachs of patients with duodenal or stomach ulcer and complications requiring scheduled surgical treatment. The results of the research into the maximum tension (durability) of the stomach mucous membrane, antrum, and the periulcer area are described. For both localizations of the ulcer, the mucous membrane of the antrum was found to exhibit the least durability, while the highest durability was exhibited by the mucous membrane of the periulcer area. In the case of bulbar ulcer, the durability of the mucous membrane was shown to decrease with an increase in the number of aggravations. An inverse relationship between the strength properties and the intensity of hydrochloric acid production was observed.
Ias'kov
I M
IM
Troshin
V P
VP
Kirillov
S K
SK
Korolev
A A
AA
Martynovich
A I
AI
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D015738:Famotidine / Q000627:therapeutic use*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology / Q000503:physiopathology*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D015738:Famotidine