Effect of insulin resistance improvement due to lifestyle intervention on overweight perimenopausal Japanese women: a preliminary study.
OBJECTIVE
We hypothesized that body composition and biomarkers of menopausal obesity would be affected by administration of a nutrition and exercise regimen. To test this hypothesis, an interventional study was performed in which perimenopausal subjects increased their daily level of physical activity and decreased their daily caloric intake for a period of 12 weeks.


METHODS
Nine patients with a chief complaint of obesity and menopausal disorders were enrolled in this study. We prescribed that the subjects engage in the daily physical activity of walking more than 10,000 steps, which is equivalent to 150 to 400 kcal per day, and reduce their daily nutritional intake by 200 kcal. Daily physical activity was measured with a computerized accelerometer, and nutrition intake was measured using food frequency questionnaires. Body composition was measured via biophysical impedance analysis. Biochemical examinations were performed before and after the study. As an assessment of glucose tolerance, homeostasis model assessment-insulin resistance (HOMA-IR) values were measured.


RESULTS
There were no significant changes in weight, body mass index, or body composition after 12 weeks. However, daily physical activity related to energy consumption was slightly but not significantly increased. Six of the nine subjects (66.7%) had abnormal baseline HOMA-IR values (mean 7.0 +/- 2.6; normal upper limit = 1.5) and demonstrated decreases in HOMA-IR values, with an average of 5.2 +/- 2.3 (P <0.05), after 12 weeks of study.


CONCLUSIONS
Our mild intervention on daily physical activity and nutrition changed HOMA-IR values, an assessment of impaired glucose tolerance. These results suggest that longitudinal mild intervention on daily physical activity and nutrition could change insulin sensitivity even without weight reduction.
Chihara
Hiromitsu
H
Department of Female Reproductive and Developmental Medicine, Graduate School of Medicine, Nippon Medical School, Japan. naru@nms.ac.jp
Kawase
Rieko
R
Otsubo
Yasuo
Y
Hiraizumi
Yoshie
Y
Takeshita
Toshiyuki
T
D044466:Asian People; D001823:Body Composition; D002149:Energy Intake / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D018149:Glucose Intolerance / Q000628:therapy*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D024821:Metabolic Syndrome / Q000628:therapy; D050177:Overweight / Q000628:therapy*; D047648:Perimenopause / Q000502:physiology*; D011795:Surveys and Questionnaires