title: Chemotherapy and cancer stem cells.
abstract: Cancer stem cells are subsets of tumor cells defined through the capacity to initiate tumors and have been linked to therapeutic resistance. In this issue of Cell Stem Cell, Todaro et al. (2007) demonstrate that targeting tumor IL-4 sensitizes colon cancer stem cells to chemotherapy.
authors: Department of Medicine, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA. rich0001@mc.duke.edu
authors: Jeremy N
authors: JN
authors: Rich
authors: Shideng
authors: S
authors: Bao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D015847:Interleukin-4 / Q000096:biosynthesis; D051379:Mice; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D009944:Organoplatinum Compounds / Q000494:pharmacology; D000077150:Oxaliplatin; D019948:Receptors, Interleukin-4 / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D019948:Receptors, Interleukin-4; D000077150:Oxaliplatin; D015847:Interleukin-4; D005472:Fluorouracil