title: Association between tipranavir plasma levels and virological response in HIV-infected patients.
abstract: The impact of tipranavir plasma levels (TPV C(min)) on virological response was examined in 36 antiretroviral-experienced HIV-infected individuals. Although TPV C(min) did not predict outcome in patients with less than five or more than eight baseline TPV-associated resistance mutations, TPV C(min) values were greater in responders than in nonresponders with five to seven baseline TPV-associated resistance mutations (38.8 vs. 13.8 g/ml, p = 0.017). Thus, therapeutic drug monitoring might be helpful in ensuring a viral response in this subset of patients.
authors: Hospital Carlos III, Madrid 28029, Spain.
authors: Judit
authors: J
authors: Morello
authors: Pilar Garcia
authors: PG
authors: Gascó
authors: Sonia
authors: S
authors: Rodriguez-Novoa
authors: Carmen
authors: C
authors: de Mendoza
authors: Francisco
authors: F
authors: Blanco
authors: Gema
authors: G
authors: Gonzalez-Pardo
authors: Beatriz
authors: B
authors: Sanz
authors: Inmaculada
authors: I
authors: Jimenez-Nacher
authors: Vincent
authors: V
authors: Soriano
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics*; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000737:chemistry / Q000821:virology; D011725:Pyridines / Q000493:pharmacokinetics*; D011753:Pyrones / Q000493:pharmacokinetics*; D013449:Sulfonamides; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D011725:Pyridines; D011753:Pyrones; D013449:Sulfonamides; C107201:tipranavir