Hand-foot syndrome with sclerodactyly-like changes in a patient treated with capecitabine.
Capecitabine, a fluoropyrimidine carbamate with antineoplastic activity, is an oral agent that was developed as a prodrug of 5-fluorouracil and is used in the treatment of metastatic colorectal and breast cancers. Multiple cutaneous adverse effects had been described with the use of this drug, but to our knowledge, specific association with capecitabine and hand-foot syndrome with sclerodactyly-like changes has been described only once. We report a patient with a colon adenocarcinoma who presented with hand-foot syndrome, with sclerodactyly-like changes induced by capecitabine.
Trindade
Felicidade
F
Department of Dermatology, Hospital dos Capuchos, Lisbon, Portugal. felicidade.trindade@gmail.com
Haro
Rosario
R
Fariña
Maria Carmen
MC
Requena
Luis
L
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D000284:Administration, Oral; D001707:Biopsy, Needle; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology*; D012720:Severity of Illness Index; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome
D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil