Detecting directional coupling in the human epileptic brain: limitations and potential pitfalls.
We study directional relationships-in the driver-responder sense-in networks of coupled nonlinear oscillators using a phase modeling approach. Specifically, we focus on the identification of drivers in clusters with varying levels of synchrony, mimicking dynamical interactions between the seizure generating region (epileptic focus) and other brain structures. We demonstrate numerically that such an identification is not always possible in a reliable manner. Using the same analysis techniques as in model systems, we study multichannel electroencephalographic recordings from two patients suffering from focal epilepsy. Our findings demonstrate that--depending on the degree of intracluster synchrony--certain subsystems can spuriously appear to be driving others, which should be taken into account when analyzing field data with unknown underlying dynamics.
Osterhage
Hannes
H
Department of Epileptology, Neurophysics Group, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. h.osterhage@web.de
Mormann
Florian
F
Wagner
Tobias
T
Lehnertz
Klaus
K
D001683:Biological Clocks; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology*; D009474:Neurons; D009435:Synaptic Transmission