title: Electrophilic ipso-iodocyclization of N-(4-methylphenyl)propiolamides: selective synthesis of 8-methyleneazaspiro[4,5]trienes.
abstract: A novel and selective method for the synthesis of 8-methylenespiro[4,5]trienes via intramolecular electrophilic ipso-iodocyclization of N-(4-methylphenyl)propiolamides has been developed. In the presence of ICl or I 2, 8-methylene-1-azaspiro[4,5]trienes were selectively prepared from the electrophilic ipso-iodocyclization of N-(4-methylphenyl)propiolamides in moderate to good yields.
authors: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
authors: Quan-Fu
authors: QF
authors: Yu
authors: Yue-Hua
authors: YH
authors: Zhang
authors: Qin
authors: Q
authors: Yin
authors: Bo-Xiao
authors: BX
authors: Tang
authors: Ri-Yuan
authors: RY
authors: Tang
authors: Ping
authors: P
authors: Zhong
authors: Jin-Heng
authors: JH
authors: Li
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D004583:Electrons; D007455:Iodine / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D001372:Aza Compounds; D013141:Spiro Compounds; D007455:Iodine