title: Carnosine-induced antidepressant-like activity in rats.
abstract: Depression is a pathological state of mood and is considered as one of the major causes of disabilities. Thus, the prevention of depression and care for individuals with depression is important. In the present study, we examined whether a single oral dose of CBEX (chicken breast extract), or carnosine (one of the major components of CBEX) affects immobility time, an index of depressive-like behavior, in the forced swimming test in male Wistar rats. CBEX tended to (P=0.09) and carnosine significantly (P<0.05) decreased immobility time in the forced swimming test. In the hippocampus, both CBEX and carnosine significantly decreased 3-methoxy-4-hydroxyphenylglycol, a major metabolite of norepinephrine, indicating that CBEX and carnosine could reduce NE activity in the hippocampus in the forced swimming test. CBEX and carnosine did not affect total locomotive distance or rearing in the open field test, suggesting that the reductions of immobility time by both treatments in the forced swimming test were not merely due to the stimulation of general motor activity. Taken together, these results suggest that CBEX has an antidepressant-like effect, which may be due, in part, to the effect of carnosine.
authors: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Higashi-ku, Fukuoka-shi, 812-8511, Japan.
authors: Shozo
authors: S
authors: Tomonaga
authors: Haruka
authors: H
authors: Yamane
authors: Eiichiro
authors: E
authors: Onitsuka
authors: Satoshi
authors: S
authors: Yamada
authors: Mikako
authors: M
authors: Sato
authors: Yoshihisa
authors: Y
authors: Takahata
authors: Fumiki
authors: F
authors: Morimatsu
authors: Mitsuhiro
authors: M
authors: Furuse
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism; D002336:Carnosine / Q000494:pharmacology*; D002645:Chickens; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D008734:Methoxyhydroxyphenylglycol; D002336:Carnosine; D009638:Norepinephrine