Effects of Helicobacter infection on developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats.
To obtain accurate results from experiments in animal models, all potential confounding variables must be identified and controlled. The authors examined the effects of Helicobacter infection on developmental toxicity resulting from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent and ubiquitous environmental contaminant. They administered different doses of TCDD to timed pregnant Helicobacter-positive and Helicobacter-negative Holtzman rats and evaluated fetal and neonatal viability. They also assessed hepatic cytochrome P450 induction and activity of the gene Cyp1a1, which are classic indicators of TCDD exposure. All rats were affected by TCDD, and Helicobacter infection seemed to have little influence on rats' susceptibility to the compound.
Kransler
Kevin M
KM
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
McGarrigle
Barbara P
BP
Russell
Robert J
RJ
Olson
James R
JR
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000831:Animals, Newborn; D019363:Cytochrome P-450 CYP1A1 / Q000096:biosynthesis; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D047109:Fetal Development / Q000187:drug effects*; D016998:Helicobacter; D016481:Helicobacter Infections / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008136:Longevity / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D051381:Rats; D017207:Rats, Sprague-Dawley; D013723:Teratogens / Q000633:toxicity*
D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens; D019363:Cytochrome P-450 CYP1A1