Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats.
The study was designed to investigate the antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. (TFH-SR) and its underlying mechanism in chronic sucrose-fed rats by evaluating its ability to regulate insulin and angiotensin || levels. Feeding of high-sucrose diet (HS: 77% of kcal from carbohydrate, 16% from protein and 6% from lipid, respectively) for 6 weeks resulted in significant rise in systolic blood pressure (SBP) by 25.60%, plasma insulin by 114.24%, triglycerides by 85.14% and activated angiotensin || contents in heart and kidney. However, TFH-SR treatment significantly suppressed the elevated hypertension, hyperinsulinemia and dyslipidemia. Furthermore, TFH-SR (especially at the dose of 150mg/kg/day) increased the circulatory blood angiotensin || level as effective as angiotensin || receptor blocker. These results indicated that TFH-SR exerted its antihypertensive effects at least in part by improving insulin sensitivity and blocking angiotensin || signal pathway. Findings of the present study suggested that TFH-SR might prove to be of potential use in the management of hyperinsulinemia in non-diabetic state with cardiovascular diseases.
Pang
Xiufeng
X
School of Life Science, East China Normal University, Shanghai 200062, PR China.
Zhao
Jingjing
J
Zhang
Wen
W
Zhuang
Xiuyuan
X
Wang
Jiesi
J
Xu
Ruiqi
R
Xu
Ziliang
Z
Qu
Weijing
W
D000809:Angiotensins / Q000097:blood / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D031263:Elaeagnaceae / Q000737:chemistry*; D047309:Flavones / Q000494:pharmacology*; D006946:Hyperinsulinism / Q000188:drug therapy; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D007668:Kidney / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D013395:Sucrose / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D000809:Angiotensins; D000959:Antihypertensive Agents; D001786:Blood Glucose; D047309:Flavones; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D013395:Sucrose