title: A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II.
abstract: Renal handling of major HDL components was studied by analyzing urine from patients with Fanconi syndrome, a rare renal proximal tubular reabsorption failure, including dysfunction of the kidney HDL receptor, cubilin. A high urinary excretion of apolipoprotein A-I and A-IV corresponding to a major part of the metabolism of these proteins was measured. In contrast, no urinary excretion of apolipoprotein A-II which is more hydrophobic and tighter bound to HDL was found. Control urines displayed absence of the three apolipoproteins. Urinary excretion of phospholipids, triglycerides, cholesterol and cholesterol esters in patients was as low as in controls. In conclusion, these data indicate that the human kidney is a major site for filtered nascent apolipoprotein A-I and A-IV but not for HDL particles.
authors: Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark. jhg@biokemi.au.dk
authors: Jonas Heilskov
authors: JH
authors: Graversen
authors: Graciela
authors: G
authors: Castro
authors: Abdelmejid
authors: A
authors: Kandoussi
authors: Henning
authors: H
authors: Nielsen
authors: Erik Ilsø
authors: EI
authors: Christensen
authors: Anthony
authors: A
authors: Norden
authors: Søren Kragh
authors: SK
authors: Moestrup
mesh_terms: D016632:Apolipoprotein A-I / Q000378:metabolism*; D016633:Apolipoprotein A-II / Q000378:metabolism*; D001054:Apolipoproteins A / Q000378:metabolism*; D005198:Fanconi Syndrome / Q000378:metabolism / Q000503:physiopathology / Q000652:urine; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D007687:Kidney Tubules, Proximal / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A; C022205:apolipoprotein A-IV