Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective.
Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis-Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.
Petti
Cathy A
CA
Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA. cathy.petti@aruplab.com
Simmon
Keith E
KE
Miro
Jose M
JM
Hoen
Bruno
B
Marco
Francesc
F
Chu
Vivian H
VH
Athan
Eugene
E
Bukovski
Suzana
S
Bouza
Emilio
E
Bradley
Suzanne
S
Fowler
Vance G
VG
Giannitsioti
Efthymia
E
Gordon
David
D
Reinbott
Porl
P
Korman
Tony
T
Lang
Selwyn
S
Garcia-de-la-Maria
Cristina
C
Raglio
Annibale
A
Morris
Arthur J
AJ
Plesiat
Patrick
P
Ryan
Suzanne
S
Doco-Lecompte
Thanh
T
Tripodi
Francesca
F
Utili
Riccardo
R
Wray
Dannah
D
Federspiel
J Jeffrey
JJ
Boisson
K
K
Reller
L Barth
LB
Murdoch
David R
DR
Woods
Christopher W
CW
D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D003030:Coagulase / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004697:Endocarditis, Bacterial / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010444:Peptide Elongation Factor Tu / Q000235:genetics; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013210:Staphylococcus / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D003030:Coagulase; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; D010444:Peptide Elongation Factor Tu