title: Severe systemic cytomegalovirus infections in patients with steroid-refractory ulcerative colitis treated by an oral microemulsion form of cyclosporine: report of two cases.
abstract: CMV reactivation is frequently observed in acute flares of ulcerative colitis (UC), particularly those which do not respond to intravenous steroids. Several recent series have suggested that, in most cases, CMV reactivation does not lead to severe complications and resolves spontaneously with the UC flare and discontinuation of immunosuppression. In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine. This is of concern, particularly in a context of increasing use of immunosuppressive drugs in UC. We propose a prophylactic and curative approach to decrease morbidity related to CMV infection in active UC.
authors: Service de gastroentérologie et nutrition, centre hospitalier universitaire, boulevard Fleming, 25000 Besançon, France. piton.gael@wanadoo.fr
authors: G
authors: G
authors: Piton
authors: A-C
authors: AC
authors: Dupont-Gossart
authors: A
authors: A
authors: Weber
authors: G
authors: G
authors: Herbein
authors: G
authors: G
authors: Viennet
authors: G
authors: G
authors: Mantion
authors: F
authors: F
authors: Carbonnel
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D003586:Cytomegalovirus Infections; D004655:Emulsions; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D004655:Emulsions; D007166:Immunosuppressive Agents; D016572:Cyclosporine