High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor.
Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required less than 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses of compound libraries.
Csajági
Csaba
C
ThalesNano Inc., Záhony u. 7., Budapest, Hungary. csaba.csajagi@thalesnano.com
Borcsek
Bernadett
B
Niesz
Krisztián
K
Kovács
Ildikó
I
Székelyhidi
Zsolt
Z
Bajkó
Zoltán
Z
Urge
László
L
Darvas
Ferenc
F
D000588:Amines / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D006358:Hot Temperature; D011312:Pressure
D000588:Amines; D002264:Carboxylic Acids; D002248:Carbon Monoxide