Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control.
Thermosensitive, transparent, and flexible semi-interpenetrating polymer networks (semi-IPNs) composed of segmented polyurethane urea/poly(N-isopropylacrylamide) (SPUU/ PNiPAAm) were new class of materials, which holds promise for its potential use as wound dressings. A series of semi-IPNs, obtained via thermal initiated polymerization of NiPAAm, were characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), dynamic viscoelastic measurements, wide-angle X-ray diffraction (WAXD), and mechanical properties. The resulting semi-IPNs were also investigated for their dynamic water contact angles, thermodynamic interaction parameters, in vitro drug release, and cell adhesion and detachment. The semi-IPNs with differing compositions possess good mechanical properties in both dry and hydrated states. In addition, NIH3T3 fibroblasts can attach to and detach from these semi-IPN films with varying temperature. In addition, these film extracts do not show significant cytotoxicity. Therefore, these materials have great potential for the construction of a new generation of dressings and cell transplantation for wound healing.
Reddy
T Thimma
TT
Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan.
Kano
Arihiro
A
Maruyama
Atsushi
A
Hadano
Michiko
M
Takahara
Atsushi
A
D000178:Acrylamides / Q000737:chemistry; D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D008027:Light; D051379:Mice; D041681:NIH 3T3 Cells; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011140:Polyurethanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013420:Sulfamethoxazole / Q000493:pharmacokinetics / Q000494:pharmacology; D013499:Surface Properties
D000178:Acrylamides; D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes; C044690:polyetherurethane urea; D013420:Sulfamethoxazole