Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice.
In daily clinical practice, the frequency of painful crises (pain rate) is an important parameter of sickle cell disease severity. We assessed the prevalence of sickle cell disease-related organ damage and complications and their relation to pain rate. Organ damage and history of vaso-occlusive complications were obtained via systematic screening of consecutive patients and by chart review. In 104 adult sickle cell patients pain rate was related to a history of acute chest syndromes, avascular osteonecrosis, iron overload, priapism and cholelithiasis. However, major disease-related complications, such as microalbuminuria and pulmonary hypertension, were detected in 23% and 24% respectively of patients without painful crises in the study period underlining the importance of systematic screening for developing organ damage in sickle cell patients irrespective of pain rate.
van Beers
Eduard J
EJ
Department of Haematology, F4-224, Academic Medical Center, PO box 22660, 1100 DD Amsterdam, The Netherlands. b.j.biemond@amc.uva.nl
van Tuijn
Charlotte F J
CF
Mac Gillavry
Melvin R
MR
van der Giessen
Anna
A
Schnog
John-John B
JJ
Biemond
Bart J
BJ
D000328:Adult; D000418:Albumins / Q000378:metabolism; D000755:Anemia, Sickle Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D015897:Comorbidity; D003404:Creatinine / Q000652:urine; D005260:Female; D005838:Genotype; D006801:Humans; D006976:Hypertension, Pulmonary; D019190:Iron Overload; D008297:Male; D010020:Osteonecrosis / Q000473:pathology; D010146:Pain; D010147:Pain Measurement; D013789:Thalassemia / Q000150:complications / Q000473:pathology* / Q000628:therapy
D000418:Albumins; D003404:Creatinine