title: Effects of ozone and ultraviolet radiation treatments on the infectivity of Toxoplasma gondii oocysts.
abstract: Clinical toxoplasmosis in humans has been epidemiologically linked to the consumption of drinking water contaminated by Toxoplasma gondii oocysts. We evaluated killing of T. gondii oocysts after ultraviolet (UV) or ozone treatments by bioassay in mice and/or cell culture. A 4-log inactivation of the oocyst/sporozoite infectivity was obtained for UV fluences >20 mJ cm(-2). In contrast, oocysts were not inactivated by ozone with an exposure (Ct) up to 9.4 mg min l (-1) in water at 20 degrees C. In conclusion, UV treatment can be an effective disinfection method to inactivate T. gondii oocysts in drinking water, but ozone did not show promise in this research.
authors: Centre de Recherche d'Expertise et de Contrôle des Eaux de Paris, 144 Avenue Paul Vaillant-Couturier, 75014 Paris, France.
authors: Aurélien
authors: A
authors: Dumètre
authors: Caroline
authors: C
authors: Le Bras
authors: Maxime
authors: M
authors: Baffet
authors: Pascale
authors: P
authors: Meneceur
authors: J P
authors: JP
authors: Dubey
authors: Francis
authors: F
authors: Derouin
authors: Jean-Pierre
authors: JP
authors: Duguet
authors: Michel
authors: M
authors: Joyeux
authors: Laurent
authors: L
authors: Moulin
mesh_terms: D000818:Animals; D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D033661:Oocysts / Q000187:drug effects / Q000528:radiation effects; D010126:Ozone / Q000494:pharmacology*; D011634:Public Health; D014122:Toxoplasma / Q000187:drug effects* / Q000472:pathogenicity / Q000528:radiation effects*; D014123:Toxoplasmosis / Q000517:prevention & control*; D014124:Toxoplasmosis, Animal / Q000517:prevention & control; D014466:Ultraviolet Rays; D014867:Water / Q000469:parasitology*; D014881:Water Supply / Q000592:standards
chemical_list: D014867:Water; D010126:Ozone