Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major.
Vitamin D25-OH and D1-25OH levels were compared with cardiac R2* (1/T2*), left ventricular ejection fraction (LVEF), age, ferritin and liver iron in 24 thalassaemia major patients. Vitamin D25-OH levels were reduced in 13/24 patients while vitamin D1-25OH levels were often elevated. Vitamin D25-OH levels decreased with age (r(2) = 0.48) and with liver iron (r(2) = 0.20). Cardiac R2* was inversely related with the ratio of D25-OH to D1-25OH levels (r(2) = 0.42). LVEF was also proportional to the D25-OH/D1-25OH ratio (r(2) = 0.49). Vitamin D deficiency may be associated with cardiac iron uptake and ventricular dysfunction in thalassaemia major patients.
Wood
John C
JC
Division of Cardiology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA. jwood@chla.usc.edu
Claster
Susan
S
Carson
Susan
S
Menteer
J D
JD
Hofstra
Thomas
T
Khanna
Rachna
R
Coates
Thomas
T
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D019190:Iron Overload / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000737:chemistry; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D013318:Stroke Volume; D065227:Transfusion Reaction; D018487:Ventricular Dysfunction, Left / Q000209:etiology; D016277:Ventricular Function, Left; D014808:Vitamin D Deficiency / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D017086:beta-Thalassemia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
D007501:Iron