title: Desmoplastic infantile ganglioglioma with a malignant course.
abstract: Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.
authors: Departments of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands. e.w.hoving@nchir.umcg.nl
authors: Eelco W
authors: EW
authors: Hoving
authors: Johan M
authors: JM
authors: Kros
authors: Ellis
authors: E
authors: Groninger
authors: Wilfred F A
authors: WF
authors: den Dunnen
mesh_terms: D018303:Ganglioglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007223:Infant; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D019635:Neurosurgical Procedures / Q000379:methods; D015173:Supratentorial Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; C513496:MIB1 ligase, human; D044767:Ubiquitin-Protein Ligases