title: Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase.
abstract: The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters.
authors: Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA.
authors: Ali
authors: A
authors: Atoui
authors: Dapeng
authors: D
authors: Bao
authors: Navgeet
authors: N
authors: Kaur
authors: W Scott
authors: WS
authors: Grayburn
authors: Ana M
authors: AM
authors: Calvo
mesh_terms: D001233:Aspergillus nidulans / Q000378:metabolism*; D001688:Biological Products / Q000096:biosynthesis*; D017353:Gene Deletion; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D007211:Indoles / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D010406:Penicillins / Q000096:biosynthesis; D010675:Pheromones / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013241:Sterigmatocystin / Q000096:biosynthesis
chemical_list: D001688:Biological Products; D007211:Indoles; D010406:Penicillins; D010675:Pheromones; C496935:terrequinone A; D013241:Sterigmatocystin; D020928:Mitogen-Activated Protein Kinases