Clinical characteristics of schizotypal-related obsessive-compulsive disorder.
In this study we compared 15 patients with DSM-IV obsessive-compulsive disorder (OCD) and schizotypal personality disorder (SPD) and 31 non-SPD OCD patients. OCD-SPD patients had poorer insight, more negative symptoms, lower functioning, more antipsychotic augmentation and more first-degree relatives with schizophrenia-spectrum disorders. A distinct clinical phenotype of OCD associated with SPD should be considered when investigating etiopathogenetic mechanisms.
Poyurovsky
Michael
M
Research Unit, Tirat Carmel Mental Health Center, Tirat Carmel, Israel. poyurovs@tx.technion.ac.il
Faragian
Sarit
S
Pashinian
Artashez
A
Heidrach
Lilah
L
Fuchs
Camil
C
Weizman
Ronit
R
Koran
Lorrin
L
D000328:Adult; D017668:Age of Onset; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005190:Family / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007557:Israel / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D010641:Phenotype; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D012720:Severity of Illness Index
D014150:Antipsychotic Agents