Bilateral oophorectomy and depressive symptoms 12 months after hysterectomy.
OBJECTIVE
This study was performed to examine whether bilateral oophorectomy is related to depressive symptoms.


METHODS
A secondary analysis of data collected from a cohort study of 1047 premenopausal women undergoing hysterectomy with or without concomitant oophorectomy for benign indications was performed. Data on depressive symptoms, based on the Profile of Mood States survey, were collected presurgically and 12 months postoperatively.


RESULTS
The effect of bilateral oophorectomy on postoperative depressive symptoms varied, depending on the presence of baseline depressive symptoms. Bilateral oophorectomy was associated with a decrease in risk of depressive symptoms in women without baseline depressive symptoms (risk ratio [RR] 0.36 [95% confidence interval (CI), 0.17, 0.78]) and did not change significantly in those with baseline depressive symptoms (RR 1.21 [95% CI, 0.73, 2.00]).


CONCLUSIONS
Bilateral oophorectomy, in comparison with unilateral or no oophorectomy, is associated with less risk of postoperative depressive symptoms in women without baseline depressive symptoms undergoing hysterectomy.
Rohl
Jacqueline
J
Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA. jacqueline.rohlmd@osumc.edu
Kjerulff
Kristen
K
Langenberg
Patricia
P
Steege
John
J
D000328:Adult; D015331:Cohort Studies; D003863:Depression / Q000209:etiology*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D017697:Premenopause; D012307:Risk Factors; D013997:Time Factors