Does N-cadherin regulate interaction of hematopoietic stem cells with their niches?
In this issue of Cell Stem Cell, Kiel et al. (2007) demonstrate that N-cadherin is not expressed on repopulating hematopoietic stem cells (HSCs) and that reduction of osteoblasts does not affect HSC frequency, suggesting that other molecular pathways may also modulate the interaction of HSCs with their niches.
Hooper
Andrea T
AT
Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Butler
Jason
J
Petit
Isabelle
I
Rafii
Shahin
S
D000818:Animals; D015820:Cadherins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D051379:Mice; D010006:Osteoblasts / Q000502:physiology
D015820:Cadherins