Direct aqueous injection LC-ESI/MS/MS analysis of water for 11 chloro- and thiomethyltriazines and metolachlor and its ethanesulfonic and oxanilic acid degradates.
A multianalyte method is reported for the determination of atrazine, simazine, propazine, and their respective dealkylated chlorotriazine metabolites; ametryn and prometryn and their respective dealkylated thiomethyltriazine metabolites; and S-metolachlor and its ethanesulfonic and oxanilic acid degradates in deionized, ground, surface, and finished drinking water. Water samples are analyzed using direct aqueous injection (DAI) liquid chromatography-electrospray ionization/mass spectrometry/mass spectrometry (LC-ESI/MS/MS). No preanalysis sample manipulation is required other than transfer of a small portion of sample to an injection vial. The lower limit of the method validation is 0.050 microg/L (ppb) for all analytes except 2,4-diamino-6-chloro- s-triazine (didealkylatrazine, DDA, or G-28273). For this compound the LLMV is 0.50 microg/L (ppb). The overall mean procedural recoveries (and percent relative standard deviations) for all water types for all analytes ranged from 95 to 101% (4.5-11%). The method validation was conducted under U.S. EPA FIFRA Good Laboratory Practice Guidelines 40 CFR 160.
Huang
Sung-Ben
SB
Environmental Safety, Syngenta Crop Protection, Inc., Greensboro, North Carolina 27419-8300, USA.
Mayer
Thomas J
TJ
Yokley
Robert A
RA
D000081:Acetamides / Q000032:analysis* / Q000378:metabolism; D000476:Alkanesulfonates / Q000032:analysis*; D001280:Atrazine / Q000032:analysis / Q000378:metabolism; D002853:Chromatography, Liquid; D006540:Herbicides / Q000032:analysis* / Q000378:metabolism; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D012680:Sensitivity and Specificity; D012839:Simazine / Q000032:analysis / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D014227:Triazines / Q000032:analysis* / Q000378:metabolism; D014867:Water / Q000032:analysis*
D000081:Acetamides; D000476:Alkanesulfonates; D006540:Herbicides; D014227:Triazines; D014867:Water; C010758:oxanilic acid; C002634:ethane sulfonate; D001280:Atrazine; D010072:Oxamic Acid; D012839:Simazine; C100043:propazine; C051786:metolachlor