High frequency of resistance to the drugs isoniazid and rifampicin among tuberculosis cases in the city of Cabo de Santo Agostinho, an urban area in Northeastern Brazil.
The objective of the present study was to investigate the frequency and risk factors for developing multidrug-resistant tuberculosis in Cabo de Santo Agostinho, PE. This was a prospective study conducted from 2000 to 2003, in which suspected cases were investigated using bacilloscopy and culturing. Out of 232 confirmed cases of tuberculosis, culturing and antibiotic susceptibility tests were performed on 174. Thirty-five of the 174 cultures showed resistance to all drugs. The frequencies of primary and acquired resistance to any drug were 14% and 50% respectively, while the frequencies of primary and acquired multidrug resistance were 8.3% and 40%. Previous tuberculosis treatment and abandonment of treatment were risk factors for drug resistance. The high levels of primary and acquired resistance to the combination of isoniazid and rifampicin contributed towards the difficulties in controlling tuberculosis transmission in the city.
Baliza
Marcilio
M
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Campus da UFPE, Avenida Moraes Rego S/N, Recife, PE.
Bach
Artur Henrique
AH
Queiroz
Gabriel Lobo de
GL
Melo
Inês Cardoso
IC
Carneiro
Maria Madileuza
MM
Albuquerque
Maria de Fátima Pessoa Militão de
Mde F
Suffys
Philip
P
Rodrigues
Laura
L
Ximenes
Ricardo
R
Lucena-Silva
Norma
N
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D001938:Brazil / Q000453:epidemiology; D004812:Epidemiologic Methods; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology*; D014505:Urban Population
D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin