New tools for genome modification in human embryonic stem cells.
Two recent papers outline improvements in gene editing technology that may facilitate the analysis of signaling networks important for development. The systems developed by both Thyagarajan and coworkers (Thyagarajan et al., 2007) in Nature Biotechnology, and Lombardo and colleagues (Lombardo et al., 2007) in Stem Cells, have the potential to advance our understanding of human embryonic stem cells.
Ptaszek
Leon M
LM
Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. lptaszek@partners.org
Cowan
Chad A
CA
D053843:DNA Mismatch Repair; D053595:Embryonic Stem Cells / Q000502:physiology*; D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D016678:Genome; D006801:Humans