Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study.
BACKGROUND
Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated.


METHODS
Brachial-ankle PWV (baPWV), IMT, and ABP were determined in 328 individuals (mean age, 65.7 +/- 6.4 years) from the general population of Ohasama, a rural Japanese community. The participants were assigned to groups with microalbuminuria and with normoalbuminuria, and their characteristics were compared. We also examined the association between microalbuminuria and baPWV, IMT, and ABP, respectively, using multivariate analyses.


RESULTS
Seventy-nine participants (24%) with microalbuminuria had significantly higher baPWV (P < 0.001) and 24-h systolic BP (SBP) (P = 0.006) than those with normoalbuminuria, although 24-h pulse pressure and mean IMT did not significantly differ between the groups. Multiple logistic regression analyses showed that baPWV, but not 24-h ABP, was independently associated with microalbuminuria (P = 0.002) when adjusted for various confounding factors. After further adjustment for 24-h SBP, the association between baPWV and microalbuminuria remained significant (P = 0.012). The trend was significant even when daytime or nighttime SBP was used instead of 24-hour SBP in this model.


CONCLUSIONS
Microalbuminuria appears to be associated with baPWV more closely than with IMT and ABP, and its association with baPWV is independent of ABP and other cardiovascular risk factors.
Ishikawa
Tomofumi
T
Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan.
Hashimoto
Junichiro
J
Morito
Rieko H
RH
Hanazawa
Tomohiro
T
Aikawa
Tomoyuki
T
Hara
Azusa
A
Shintani
Yoriko
Y
Metoki
Hirohito
H
Inoue
Ryusuke
R
Asayama
Kei
K
Kikuya
Masahiro
M
Ohkubo
Takayoshi
T
Totsune
Kazuhito
K
Hoshi
Haruhisa
H
Satoh
Hiroshi
H
Imai
Yutaka
Y
D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D001916:Brachial Artery / Q000502:physiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012424:Rural Population; D012720:Severity of Illness Index; D016909:Tibial Arteries / Q000503:physiopathology*; D014652:Vascular Diseases / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology
D015415:Biomarkers