title: The effect of sevoflurane-induced hypotension in combination with acute hypervolaemic haemodilution on middle cerebral artery flow velocity in surgical patients.
abstract: OBJECTIVE
  This study was carried out to clarify the effect of the combination of acute hypervolaemic haemodilution and hypotensive anaesthesia induced with sevoflurane on human middle cerebral artery flow velocity using transcranial Doppler ultrasonography.
  
  
  METHODS
  Thirty patients who were maintained with N2O-O2-sevoflurane anaesthesia undergoing hip surgery were randomly divided into two groups (no controlled hypotension group, Group A, and controlled hypotension group, Group B). Haemodilution was produced by acute preoperative infusion of 1000 mL of hydroxyethylstarch without removing blood in both groups. Mean arterial pressure was maintained at approximately 95 mmHg in Group A and at 55 mmHg for 80 min by increasing the inspired concentration of sevoflurane in Group B. Middle cerebral artery flow velocity was measured before haemodilution, after haemodilution, 80 min after starting hypotension, and 60 min after recovery from hypotension.
  
  
  RESULTS
  Middle cerebral artery flow velocity significantly increased in both groups after haemodilution; by 28%, in Group A, P < 0.05 vs. before haemodilution and by 30% vs. before haemodilution in Group B, P < 0.05). During controlled hypotension, it decreased towards the pre-haemodilution value (P < 0.05 vs. after haemodilution).
  
  
  CONCLUSIONS
  Sevoflurane-induced hypotension to a mean arterial pressure of 55 mmHg would reduce middle cerebral artery flow that had been increased by acute hypervolaemic haemodilution, such as haematocrit value of 26%, whereas it could preserve the flow in pre-haemodilution condition during normocapnia.
authors: Nagasaki Rosai Hospital, Department of Anesthesia, Sasebo, Nagasaki, Japan. fukusaki@na-robyo.jp
authors: M
authors: M
authors: Fukusaki
authors: M
authors: M
authors: Kanaide
authors: C
authors: C
authors: Inadomi
authors: M
authors: M
authors: Takada
authors: Y
authors: Y
authors: Terao
authors: K
authors: K
authors: Sumikawa
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation; D019644:Arthroplasty, Replacement, Hip; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000187:drug effects* / Q000503:physiopathology; D016343:Monitoring, Intraoperative / Q000379:methods*; D000077149:Sevoflurane; D016037:Single-Blind Method; D018608:Ultrasonography, Doppler
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane