[Strophanthin induced changes in the ion currents of Lymnaea stagnalis and Planorbis corneus neurons].
Experiments on isolated neurons of Lymnaea stagnalis and Planorbis corneus using the intracellular dialysis and fixed membrane potential techniques showed that strophanthin G in a concentration range from 10(-11) to 10(-6) M produce dolse-dependent reversible suppression of the ion currents in potassium, calcium, and sodium channels. At the maximum concentration (10(-6) M), the maximum suppression (up to 55% of that in the control) was observed for the calcium ion current. At the minimum concentration (10(-12) M), the drug did not influence the sodium ion current, but slightly (approximately by 5%) increased the calcium and potassium ion currents. In addition, strophanthin accelerated the inactivation of slow potassium ion currents.
Ignatov
Iu D
IuD
Vislobokov
A I
AI
Borisova
V A
VA
D000818:Animals; D002118:Calcium / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D049851:Gastropoda / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D007473:Ion Channels / Q000502:physiology; D008195:Lymnaea / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000502:physiology; D012964:Sodium / Q000502:physiology; D013328:Strophanthins / Q000494:pharmacology*
D002316:Cardiotonic Agents; D007473:Ion Channels; D013328:Strophanthins; D012964:Sodium; D011188:Potassium; D002118:Calcium