title: Optical coherence tomography of the larynx in the awake patient.
abstract: OBJECTIVE
  To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system.
  
  
  METHODS
  Prospective clinical trial.
  
  
  METHODS
  Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization.
  
  
  RESULTS
  Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the probe and allowing more accurate apposition of the probe onto target tissues, which is critical for transnasal laryngeal imaging.
  
  
  CONCLUSIONS
  This study demonstrates the feasibility of awake transnasal laryngeal optical coherence tomography and identifies key instrumentation needed to obtain useful images.
authors: Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
authors: Ali
authors: A
authors: Sepehr
authors: William B
authors: WB
authors: Armstrong
authors: Shuguang
authors: S
authors: Guo
authors: Jianping
authors: J
authors: Su
authors: Jorge
authors: J
authors: Perez
authors: Zhonping
authors: Z
authors: Chen
authors: Brian J F
authors: BJ
authors: Wong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D007830:Larynx; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000295:instrumentation*