Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.
Kim
Eun-Young
EY
Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Suite 200, Chicago, IL 60611, USA. e-kim@northwestern.edu
Veazey
Ronald S
RS
Zahn
Roland
R
McEvers
Kimberly J
KJ
Baumeister
Susanne H C
SH
Foster
Gabriel J
GJ
Rett
Melisa D
MD
Newberg
Michael H
MH
Kuroda
Marcelo J
MJ
Rieber
E Peter
EP
Piatak
Michael
M
Lifson
Jeffrey D
JD
Letvin
Norman L
NL
Wolinsky
Steven M
SM
Schmitz
Jörn E
JE
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015683:Gene Products, gag / Q000097:blood; D015696:Gene Products, tat / Q000097:blood; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology; D009154:Mutation / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014779:Virus Replication
D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015696:Gene Products, tat; D015395:Histocompatibility Antigens Class I; C110764:Mamu-A 01 antigen