title: Tinnitus treatment with memantine.
abstract: OBJECTIVE
  To evaluate efficacy and safety of memantine in the treatment of tinnitus.
  
  
  METHODS
  Prospective, randomized, double-blind crossover study.
  
  
  METHODS
  A total of 60 patients with tinnitus were randomized into a double-blind, placebo-controlled, prospective crossover study. Patients each received up to 20 mg memantine and placebo for 90 days, separated by a 30-day washout period. Treatment effects were assessed by using the Tinnitus Handicap Inventory (THI). A total of 43 patients completed the trial.
  
  
  RESULTS
  There was no significant improvement of THI score after memantine treatment compared with placebo. A possible tendency for delayed effects of memantine was observed. The incidence of side effects during memantine treatment was 9.4 percent, leading to interruption of treatment in all cases.
  
  
  CONCLUSIONS
  This study does not provide evidence to recommend memantine for the treatment of tinnitus. A possible late effect of the drug should be evaluated in further studies with longer observation periods.
authors: OTOSUL-Otorrinolaringologia Sul-Fluminense. rfigueiredo@otosul.com.br
authors: Ricardo Rodrigues
authors: RR
authors: Figueiredo
authors: Berthold
authors: B
authors: Langguth
authors: Patricia
authors: P
authors: Mello de Oliveira
authors: Andréia
authors: A
authors: Aparecida de Azevedo
mesh_terms: D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004311:Double-Blind Method; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008559:Memantine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D015990:Placebo Effect; D014012:Tinnitus / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D018691:Excitatory Amino Acid Antagonists; D008559:Memantine