[Experimental study of the radioprotective action of melanin on the somatic development during irradiation in the antenatal period of ontogenesis].
Daily introduction per os of the exogenous melanin in a doze of weight of 10 mg/kg pregnant female rats Wistar eliminated the functional deficiency of somatic development revealed at posterity at chronic gamma-irradiation in a doze 1.00-1.25 Gy for all period of pregnancy. The irradiation or introduction melanin antenatal to a phase ontogenesis resulted in stimulation of the immune answer, which was determined at offspring on 3rd week after birth. On the basis of the received data it is concluded presence radioembryoprotective actions melanin in the relation embryotoxic effects of small dozes of ionizing radiation and its participation in regulation immunogenes.
Izmest'eva
O S
OS
Dubovik
B V
BV
Zhavoronkov
L P
LP
Semin
Iu A
IuA
Sharetskiĭ
A N
AN
Izmest'ev
V I
VI
Posadskaia
V M
VM
D000284:Administration, Oral; D000818:Animals; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008543:Melanins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D038081:Organogenesis / Q000187:drug effects / Q000528:radiation effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D008543:Melanins; D011837:Radiation-Protective Agents