Green procedure for the preparation of scented alcohols from carbonyl compounds.
Several alcohols--interesting as cosmetic fragrances whose main preparative route on an industrial scale or in the research laboratory is the reduction of the corresponding carbonyl compound--were obtained by a solvent-free methodology in a green chemistry context. The process involves the simple mixing of the carbonyl compound with sodium borohydride dispersed in wet alumina in the solid state; the conversions of the carbonyl compounds were obtained in good yields within short reaction times, without energy consumption. The following carbinols were studied: octan-3-ol, 2-cineolylols (endo-exo mixture), alpha-ionol, 4-methylbenzyl alcohol, 1-phenylethanol, trans-cinnamyl alcohol, p-anisyl alcohol, 4-phenyl-3-buten-2-ol.
Villa
Carla
C
Dipartimento di Scienze Farmaceutiche dell'Università, Genova, Italy. carlavilla@unige.it
Trucchi
Beatrice
B
Gambaro
Raffaella
R
Baldassari
Sara
S
D000438:Alcohols / Q000138:chemical synthesis*; D000447:Aldehydes / Q000737:chemistry*; D001894:Borohydrides / Q000737:chemistry; D003358:Cosmetics / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009812:Odorants; D009904:Optical Rotation; D013055:Spectrophotometry, Infrared
D000438:Alcohols; D000447:Aldehydes; D001894:Borohydrides; D003358:Cosmetics; D007659:Ketones; C025364:sodium borohydride