Effect of lumen narrowing within sirolimus-eluting stents on proximal and distal vessel segments.
BACKGROUND
Flow dynamics and shear stress may influence downstream vessel segments. The aim of this study was to investigate the potential impact of lumen narrowing within sirolimus-eluting stents (SES) on vessel response at adjacent reference sites.


RESULTS
In 135 patients after SES implantation, minimal lumen area (MLA) within the stent and average lumen area at distal or proximal adjacent reference segments (5 mm) were obtained at baseline and follow up. In the smaller in-stent MLA group (MLA <3 mm(2)), lumen area decreased significantly at the distal reference compared with the larger in-stent MLA group (MLA >or=3 mm(2)), although no significant difference was seen at the proximal reference.


CONCLUSIONS
In-stent lumen patency may influence vascular responses at adjacent reference segments after SES implantation.
Waseda
Katsuhisa
K
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, CA, USA
Ako
Junya
J
Kaneda
Hideaki
H
Miyazawa
Akiyoshi
A
Shimada
Yoshihisa
Y
Morino
Yoshihiro
Y
Honda
Yasuhiro
Y
Fitzgerald
Peter J
PJ
D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012449:Safety; D020123:Sirolimus / Q000008:administration & dosage*; D014463:Ultrasonography
D007166:Immunosuppressive Agents; D020123:Sirolimus