title: The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery.
abstract: BACKGROUND
  Previous studies addressing the changes in serum visfatin levels after bariatric surgery yielded conflicting results.
  
  
  METHODS
  We measured serum visfatin levels in 41 morbidly obese women before bariatric surgery and after losing at least 15% of the initial weight, and analyzed the results taking into account the type of surgery, reproductive and diabetic status, among others. Body mass index, waist circumference, lipid profile, and insulin resistance determined by homeostasis model assessment (HOMA-IR) were also measured.
  
  
  RESULTS
  Patients lost 30.3 +/- 6.1% of the initial body weight, and serum visfatin levels increased from 22.2 +/- 20.9 to 32.2 +/- 27.6 ng/ml (P = 0.031). A multiple regression model (R (2) = 0.314, F = 3.555, P = 0.017) including the percentage of weight loss, changes in waist circumference, HOMA-IR, high-density lipoprotein-cholesterol, and triglycerides (also expressed as percentage from baseline), the surgical procedure, time elapsed since surgery, and previous diabetic status as independent variables showed that weight loss (beta = -0.670, P = 0.010), previous diabetic status (beta = -0.330, P = 0.036), and change in waist circumference (beta = 0.556, P = 0.031) were the main determinants of the percentual increase in serum visfatin levels observed after bariatric surgery.
  
  
  CONCLUSIONS
  Serum visfatin increased after bariatric surgery in relation to the amount of weight lost and to the changes in waist circumference, and this increase was higher in diabetic patients.
authors: Department of Endocrinology, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, Carretera de Colmenar Km. 9.1, Madrid, Spain.
authors: José I
authors: JI
authors: Botella-Carretero
authors: Manuel
authors: M
authors: Luque-Ramírez
authors: Francisco
authors: F
authors: Alvarez-Blasco
authors: Roberto
authors: R
authors: Peromingo
authors: José L
authors: JL
authors: San Millán
authors: Héctor F
authors: HF
authors: Escobar-Morreale
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications / Q000601:surgery*; D017698:Postmenopause; D017697:Premenopause; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human