Three live-birth pregnancies in a woman with Williams syndrome.
OBJECTIVE
Maternal Williams syndrome with their associated (cardiac) malformations is rarely encountered during pregnancy.


METHODS
We report on a patient with Williams syndrome who has had 3 live-birth pregnancies.


RESULTS
Several noncardiac, mainly fetal, complications need to be anticipated: premature labor, intrauterine growth restriction with subsequent small-for-gestational-age offspring, and recurrence of congenital heart disease or similar syndromes.


CONCLUSIONS
The present case report illustrates that multiple live-birth pregnancies are possible in women with Williams syndrome, and it advocates the need for regular multidisciplinary assessments prior to and during pregnancy.
van der Tuuk
Karin
K
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
Drenthen
Willem
W
Moons
Philip
P
Budts
Werner
W
D000328:Adult; D005260:Female; D006801:Humans; D050498:Live Birth; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D018980:Williams Syndrome / Q000503:physiopathology*