Antistreptococcal activity of AR-709 compared to that of other agents.
Against 300 strains of pneumococci and 100 group A streptococci of differing beta-lactam, macrolide, and quinolone resistance phenotypes, AR-709 was very active, with all MICs being < or =2 microg/ml. Furthermore, AR-709 was active against strains that were both susceptible and resistant to trimethoprim-sulfamethoxazole.
Smith
Kathy
K
Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.
Ednie
Lois M
LM
Appelbaum
Peter C
PC
Hawser
Stephen
S
Lociuro
Sergio
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000145:classification / Q000187:drug effects*; D013762:Tetrahydrofolate Dehydrogenase / Q000187:drug effects; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013762:Tetrahydrofolate Dehydrogenase