Gene regulation by transcription factors and microRNAs.
The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor- and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.
Hobert
Oliver
O
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA. or38@columbia.edu
D000818:Animals; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010641:Phenotype; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D035683:MicroRNAs; D014157:Transcription Factors