Modeling the duration of the latency period after preterm premature rupture of the membranes according to maternal and pregnancy characteristics: DOMINOS study.
OBJECTIVE
The objective was to assess the effects of maternal and pregnancy characteristics on the rupture-to-delivery interval.


METHODS
DOMINOS study, a descriptive prospective population-based study, recorded the characteristics of 598 pregnancies with preterm premature rupture of the membranes (PPROM) between 24 and 34 weeks' gestation. Univariate and multivariate analyses was performed that were likely to affect the rupture-to-delivery interval.


RESULTS
Sixty percent of babies were born within 1 week. Three factors shortened the delay: multiple pregnancies, preterm labor before PPROM, and PPROM after 32 weeks. The estimated median interval for a single pregnancy occurring between 32 and 34 weeks' gestation was 4.68 days (95% CI 3.90; 5.61). This interval was shorter in multiple pregnancies, but doubled with PPROM before 32 weeks' gestation.


CONCLUSIONS
The estimate of the rupture-to-delivery interval according to maternal and pregnancy characteristics may help in comparing the benefit in terms of reduction of prematurity with the risk of complications such as chorioamnionitis or fetal distress.
Pasquier
Jean-Charles
JC
Department of Obstetrics, Edouard Herriot Hospital, Hospices Civils de Lyon and Claude Bernard University, Lyon, France. jean-charles.pasquier@usherbrooke.ca
Rabilloud
Muriel
M
Picaud
Jean-Charles
JC
Claris
Olivier
O
Ecochard
René
R
Moret
Stephanie
S
Mellier
Georges
G
D000293:Adolescent; D000328:Adult; D002821:Chorioamnionitis / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005316:Fetal Distress / Q000453:epidemiology / Q000517:prevention & control; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology*; D006306:Health Surveys; D006801:Humans; D008954:Models, Biological; D015999:Multivariate Analysis; D007752:Obstetric Labor, Premature / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors