A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis.
Santhosh
Sundaresan
S
Witt
Heiko
H
te Morsche
René H M
RH
Nemoda
Zsofia
Z
Molnár
Tamás
T
Pap
Akos
A
Jansen
Jan B M J
JB
Drenth
Joost P H
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000235:genetics* / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide; D014357:Trypsin / Q000235:genetics*; D014362:Trypsinogen / Q000235:genetics*
D017931:DNA Primers; C064831:PRSS2 protein, human; D014362:Trypsinogen; D014357:Trypsin