title: Controlled flow-through dissolution methodology: a high-performance system.
abstract: Measuring release rates using compendial systems, especially for sparingly soluble compounds, often produces complex results with less than desired precision and lacks relevance to key formulation or biological parameters. A flow-through approach was used by focusing on convective diffusion and controlling certain key physical-chemical factors. Results are presented for an automated multisample flow-through system that displays significant advantages over compendial (1) stirred and (2) flow-through systems. Advantages include precision, physicochemical, and in vivo relevance, along with analytical and formulation sensitivity. The convective diffusion/dissolution process was also simulated by using finite element modeling with predictions agreeing with measurements to within a few percent.
authors: Alcon Research, Ltd., Fort Worth, TX, USA. larry.stevens@alconlabs.com
authors: Larry E
authors: LE
authors: Stevens
authors: Paul J
authors: PJ
authors: Missel
authors: Alan L
authors: AL
authors: Weiner
mesh_terms: D000818:Animals; D011817:Rabbits; D012995:Solubility; D013678:Technology, Pharmaceutical