Niche regulation of muscle satellite cell self-renewal and differentiation.
Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.
Kuang
Shihuan
S
The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
Gillespie
Mark A
MA
Rudnicki
Michael A
MA
D000818:Animals; D002450:Cell Communication; D018797:Cell Cycle Proteins / Q000502:physiology; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018482:Muscle, Skeletal / Q000502:physiology*; D009136:Muscular Dystrophies / Q000628:therapy; D051787:Myogenic Regulatory Factor 5 / Q000502:physiology; D051763:PAX7 Transcription Factor / Q000502:physiology; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000166:cytology / Q000502:physiology*; D033581:Stem Cell Transplantation
D018797:Cell Cycle Proteins; D051787:Myogenic Regulatory Factor 5; D051763:PAX7 Transcription Factor