title: Validation of a predictive method for an accurate assessment of resting energy expenditure in medical mechanically ventilated patients.
abstract: OBJECTIVE
  Use comparison with indirect calorimetry to confirm the ability of our previously described equation to predict resting energy expenditure in mechanically ventilated patients.
  
  
  METHODS
  Prospective, validation study.
  
  
  METHODS
  Eighteen-bed, medical intensive care unit at a teaching hospital.
  
  
  METHODS
  All adult patients intubated >24 hrs were assessed for eligibility. Exclusion criteria were clinical situations that could contribute to erroneous calorimetric measurements.
  
  
  METHODS
  Resting energy expenditure was calculated using the original Harris-Benedict equations and those corrected for usual stress factors, the Swinamer equation, the Fusco equation, the Ireton-Jones equation, and our equation: resting energy expenditure (kcal/day) = 8 x weight (kg) + 14 x height (cm) + 32 x minute ventilation (L/min) + 94 x temperature (degrees C) - 4834.
  
  
  RESULTS
  Resting energy expenditure was measured by indirect calorimetry for the 45 included patients. Resting energy expenditure calculated with our predictive model correlated with the measured resting energy expenditure (r2 = .62, p < .0001), and Bland-Altman analysis showed a mean bias of -192 +/- 277 kcal/day, with limits of agreement ranging from -735 to 351 kcal/day. Resting energy expenditure calculated with the Harris-Benedict equations was more weakly correlated with measured resting energy expenditure (r2 = .41, p < .0001), with Bland-Altman analysis showing a mean bias of 279 +/- 346 kcal/day between them and the limits of agreement ranging from -399 to 957 kcal/day. Applying usual stress-correction factors to the Harris-Benedict equations generated wide variability, and the correlation with measured resting energy expenditure was poorer (r2 = .18, p < .0001), with Bland-Altman analysis showing a mean bias of -357 +/- 750 kcal/day and limits of agreement ranging from -1827 to 1113 kcal/day. The use of the Swinamer, Fusco, or Ireton-Jones predictive methods yielded weaker correlation between calculated and measured resting energy expenditure (r2 = .41, p < .0001; r2 = .38, p < .0001; r2 = .39, p < .0001, respectively) than our equation, and Bland-Altman analysis showed no improvement in agreement and variability between methods.
  
  
  CONCLUSIONS
  The Faisy equation, based on static (height), less stable (weight), and dynamic biometric variables (temperature and minute ventilation), provided precise and unbiased resting energy expenditure estimations in mechanically ventilated patients.
authors: Intensive Care Unit, Hôpital de l'Enfant-Jésus, Quebec, Canada.
authors: Jean-François
authors: JF
authors: Savard
authors: Christophe
authors: C
authors: Faisy
authors: Nicolas
authors: N
authors: Lerolle
authors: Emmanuel
authors: E
authors: Guerot
authors: Jean-Luc
authors: JL
authors: Diehl
authors: Jean-Yves
authors: JY
authors: Fagon
mesh_terms: D018806:APACHE; D000886:Anthropometry; D001481:Basal Metabolism; D002153:Calorimetry, Indirect / Q000379:methods*; D003422:Critical Care; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012121:Respiration, Artificial