Directing stem cell homing.
Stem cell-based regeneration depends partly on the delivery of stem cells to the damaged area. Recently in Nature Medicine, Sackstein et al. (2008) report that ex vivo fucosylation of surface CD44 promoted efficient adhesive interactions of manipulated mesenchymal stem cells with marrow vasculature and subsequent homing to endosteal surfaces.
Khaldoyanidi
Sophia
S
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA. skhaldoyanidi@tpims.org
D000818:Animals; D001853:Bone Marrow / Q000098:blood supply / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*
C497483:CD44 protein, human; D018960:Hyaluronan Receptors