title: In situ generation of Mes2Mg as a non-nucleophilic carbon-centred base reagent for the efficient one-pot conversion of ketones to silyl enol ethers.
abstract: Treatment of commercially available MesMgBr with 1,4-dioxane produces the key Mes(2)Mg reagent in situ which then mediates the deprotonation of ketones to deliver trimethylsilyl enol ethers, at readily accessible temperatures and without any nucleophilic addition, in an expedient and high yielding one-pot process.
authors: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UK G1 1XL. w.kerr@strath.ac.uk
authors: William J
authors: WJ
authors: Kerr
authors: Allan J B
authors: AJ
authors: Watson
authors: Douglas
authors: D
authors: Hayes
mesh_terms: D002244:Carbon / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D004987:Ethers; D007659:Ketones; D017616:Magnesium Compounds; D012821:Silanes; D014297:Trimethylsilyl Compounds; D002244:Carbon