Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro.
Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.
Purfield
Anne E
AE
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599-7435, USA.
Tidwell
Richard R
RR
Meshnick
Steven R
SR
D000818:Animals; D000962:Antimalarials / Q000378:metabolism* / Q000494:pharmacology*; D053626:Atovaquone / Q000378:metabolism / Q000494:pharmacology; D001550:Benzamidines / Q000378:metabolism* / Q000494:pharmacology*; D002738:Chloroquine / Q000378:metabolism / Q000494:pharmacology; D004347:Drug Interactions; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D001550:Benzamidines; C033286:furamidine; D002738:Chloroquine; C458513:pafuramidine; D053626:Atovaquone