The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.
We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.
Todd
Alan K
AK
CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Neidle
Stephen
S
D001483:Base Sequence; D016384:Consensus Sequence; D054856:G-Quadruplexes; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D011401:Promoter Regions, Genetic; D050436:Regulatory Elements, Transcriptional; D016329:Sp1 Transcription Factor / Q000378:metabolism*
D016329:Sp1 Transcription Factor