title: Application of wireless capsule endoscopy for the evaluation of iron deficiency anemia in patients with ileal pouches.
abstract: BACKGROUND
  Although wireless capsule endoscopy (WCE) is widely used in the assessment of small bowel pathology, its application in patients with ileal pouches has not been evaluated. Persistent anemia has been observed in patients with ileal pouches, for which identification of etiology can be challenging.
  
  
  OBJECTIVE
  To assess the utility of WCE in ileal pouch patients with persistent anemia in conjunction with other diagnostic modalities.
  
  
  METHODS
  Ulcerative colitis patients with persistent anemia (hemoglobin <10 g/dL) at least 12 months after either ileal pouch-anal anastomosis or continent ileostomy surgery were studied. Esophagogastroduodenoscopy, pouch endoscopy, WCE, and celiac disease serology were studied. The final diagnosis of the etiology of anemia was based on the results from the combined assessment of clinical, endoscopic, histologic, and laboratory data.
  
  
  RESULTS
  Seventeen ileal pouch patients (10 females, 7 males) with underlying inflammatory bowel disease were studied with a mean age 42.1+/-15.2 years. Nine patients (52.9%) had active pouchitis and 3 (17.6%) had Crohn's disease (CD). WCE was successfully completed in 16 patients (94.1%). Suspected causes of anemia were identified in 5 patients (29.4%): 2 patients with CD of the pouch and 1 patient with celiac disease, detected by esophagogastroduodenoscopy, pouch endoscopy, small bowel biopsy, and celiac disease serology, and 1 patient with CD of the small bowel and 1 patient with small bowel arterio-venous malformations shown on WCE only.
  
  
  CONCLUSIONS
  WCE seemed to be feasible and well tolerated in patients with ileal pouches. WCE provided additional diagnostic information in the pouch patients with anemia.
authors: Department of Gastroenterology/Hepatology, Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, OH, USA.
authors: Bo
authors: B
authors: Shen
authors: Feza H
authors: FH
authors: Remzi
authors: Jan
authors: J
authors: Santisi
authors: Bret A
authors: BA
authors: Lashner
authors: Aaron
authors: A
authors: Brzezinski
authors: Victor W
authors: VW
authors: Fazio
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis*; D053704:Capsule Endoscopy / Q000009:adverse effects / Q000379:methods*; D003093:Colitis, Ulcerative / Q000601:surgery; D039021:Colonic Pouches; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019449:Pouchitis / Q000473:pathology; D011446:Prospective Studies