title: Leukocytoclastic vasculitis with severe cardiac involvement in an infant: a case report.
abstract: Severe visceral involvement in leukocytoclastic vasculitis is rare. We report here the case of a 2-month-old male infant with leukocytoclastic vasculitis who initially presented with fever and skin purpura. Endomyocarditis with mitral valve regurgitation, multiple hepatic infarction, and pulmonary hemorrhage developed later. The patient was successfully managed with an aggressive treatment of high frequency oscillation ventilation and extracorporeal membrane oxygenation together with corticosteroid and azathioprine therapy for 3 months. Valvuloplasty was also performed due to irreversible damage of the mitral valve, although long-term oral anticongestive medications were also needed.
authors: Department of Pediatrics, National Taiwan University Hospital, No. 7 Chung San South Road, Taipei, Taiwan, Republic of China.
authors: Jui-Tsung
authors: JT
authors: Hung
authors: Yao-Hsu
authors: YH
authors: Yang
authors: Cheng-Hsiang
authors: CH
authors: Hsiao
authors: Hsin-Hui
authors: HH
authors: Yu
authors: Jyh-Hong
authors: JH
authors: Lee
authors: Li-Chieh
authors: LC
authors: Wang
authors: Bor-Luen
authors: BL
authors: Chiang
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002404:Catheterization; D015199:Extracorporeal Membrane Oxygenation; D006612:High-Frequency Ventilation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008297:Male; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000628:therapy; D009205:Myocarditis / Q000209:etiology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D001379:Azathioprine