title: Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells.
abstract: Previous studies from our laboratory demonstrated that 17beta-estradiol (E2) rapidly inhibits Cl(-) secretion in rat and human distal colonic epithelium. The inhibition has been shown to occur via targeting of a basolateral K(+) channel identified as the KCNQ1 (KvLQT1) channel. E2 indirectly modulates the channel activity via a cascade of second messengers which are rapidly phosphorylated in response to E2. The anti-secretory mechanism may be the manner by which E2 induces fluid retention in the intestine during periods of high circulating plasma E2. Here we review the sex-dependent and estrous cycle regulation of this novel rapid response to E2. The inhibition of KCNQ1 channel activity and Cl(-) secretion will be of interest in the future in the investigation of the retentive effects of estrogen in female tissue and also in the study of secretory disorders and drugable targets of the intestine.
authors: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. fomahony@rcsi.ie
authors: Fiona
authors: F
authors: O'Mahony
authors: Brian J
authors: BJ
authors: Harvey
mesh_terms: D000818:Animals; D003106:Colon / Q000166:cytology* / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism; D030762:Estrous Cycle; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D051657:KCNQ1 Potassium Channel / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D012737:Sex Factors; D015398:Signal Transduction
chemical_list: D004967:Estrogens; D051657:KCNQ1 Potassium Channel; D015221:Potassium Channels; D004958:Estradiol