title: Effect of experimental diabetes on craniofacial growth in rats.
abstract: OBJECTIVE
  The goal of this study was to assess the effect of type 1 diabetes mellitus (T1DM) on the craniofacial growth and skeletal maturation using the STZ-DM rat model.
  
  
  METHODS
  Experimental T1DM was induced in 3-week-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin (STZ). Lateral and dorsoventral X-rays of the head were taken at the age of 7 weeks. The X-rays were scanned, digitised and selected linear distances were measured and analysed statistically.
  
  
  RESULTS
  In STZ-DM statistical analysis of results revealed a reduction in growth of most of the linear measurements in the neurocranium and mandible by X-ray analysis, and all measurements were significantly lower in viscerocranium.
  
  
  CONCLUSIONS
  Uncontrolled T1DM reduces craniofacial growth, resulting in retardation of skeletal development.
authors: Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo 113-8549, Japan. monaabbassy@gmail.com
authors: Mona Aly
authors: MA
authors: Abbassy
authors: Ippei
authors: I
authors: Watari
authors: Kunimichi
authors: K
authors: Soma
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002508:Cephalometry; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D008297:Male; D011859:Radiography; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000000981:diagnostic imaging / Q000254:growth & development*
chemical_list: D001786:Blood Glucose