title: Small cell carcinoma of the extrahepatic bile duct diagnosed with EUS-FNA and effectively treated with chemoradiation.
abstract: Small cell carcinoma of the bile duct system is extremely rare, and surgical procedures have been complicated by early hematogenous dissemination. In this study, we report a patient with small cell carcinoma of the bile duct system presenting with jaundice. The diagnosis was made early by endoscopic ultrasonography-guided fine needle aspiration biopsy (EUS-FNA). We performed radiation therapy of a total of 30 Gy, resulting in a marked decrease of serum neuron specific enolase levels and amelioration of jaundice, which had been resistant to drainage procedures. The patient was then treated with combined chemotherapy of cisplatin and CPT-11, which resulted in the disappearance of the tumor mass by image tests.
authors: Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan. arakuran@hsp.md.shinshu-u.ac.jp
authors: Norikazu
authors: N
authors: Arakura
authors: Takashi
authors: T
authors: Muraki
authors: Kenichi
authors: K
authors: Komatsu
authors: Yayoi
authors: Y
authors: Ozaki
authors: Hideaki
authors: H
authors: Hamano
authors: Eiji
authors: E
authors: Tanaka
authors: Shigeyuki
authors: S
authors: Kawa
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D017734:Bile Ducts, Extrahepatic / Q000187:drug effects / Q000473:pathology*; D044963:Biopsy, Fine-Needle / Q000379:methods; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D019160:Endosonography; D006801:Humans; D000077146:Irinotecan; D008297:Male
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin