Chemotherapy and cancer stem cells.
Cancer stem cells are subsets of tumor cells defined through the capacity to initiate tumors and have been linked to therapeutic resistance. In this issue of Cell Stem Cell, Todaro et al. (2007) demonstrate that targeting tumor IL-4 sensitizes colon cancer stem cells to chemotherapy.
Rich
Jeremy N
JN
Department of Medicine, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA. rich0001@mc.duke.edu
Bao
Shideng
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D015847:Interleukin-4 / Q000096:biosynthesis; D051379:Mice; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D009944:Organoplatinum Compounds / Q000494:pharmacology; D000077150:Oxaliplatin; D019948:Receptors, Interleukin-4 / Q000378:metabolism
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D019948:Receptors, Interleukin-4; D000077150:Oxaliplatin; D015847:Interleukin-4; D005472:Fluorouracil