title: [Oleksandr Solomonovych Tsyperovych--gifted enzymologist, scientist and practician].
abstract: Professor O. S. Tsyperovich (15.12.1910-20.12.1976), Doctor of biology, was born in the city of Odessa, graduated from the Faculty of Chemistry of Shevchenko Kyiv State University as a specialist in organic chemistry (1930-1935). In 1935-1941 he worked at the Institute of Biochemistry of the Academy of Sciences of the Ukr.SSR (Kyiv) as a junior research worker, and then as a senior research worker at the Department of Enzymology. In 1941 O. S. Tsyperovich defended the thesis for the Candidate's degree dedicated to the investigation of synthetic effect of proteolytic enzymes, and he was awarded the title of the senior research worker. In 1941-1945 O. S. Tsyperovich struggled in the ranks of the Soviet Army, was awarded the Red Star Order, medals For Defense of Caucasus, For the Victory over Germany in the Great Patriotic War of 1941-1945. In 1946-1976 O. S. Tsyperovich worked at the Institute of Biochemistry of the Academy of Sciences of Ukraine. When investigating the mechanism of proteins denaturation he discovered the phenomenon of their "denaturational stabilization". New technological schemes of production of pepsin preparations were elaborated on the basis of the method of autholysis proposed by him. In 1954 O. S. Tsyperovich defended the thesis for the Doctor's Degree and was awarded the order The Badge of Honor. Beginning from 1963 he headed the laboratory, and from 1966 -- the Department of Chemistry and Biochemistry of Enzymes, in 1969 the title of professor was conferred on him. In the 60-70's O. S. Tsyperovich investigated hydrolytic enzymes of microorganisms with the purpose of their use in industry. Thus, the method of production of the preparation "pronasa" from Streptomyces griseus was developed, aminopeptidases, dipeptidases, a-amylase, cellulases, were investigated. Investigations in the field of preparative enzymology resulted in the development of technological scheme for creation of the following drugs for the purposes of medicine: medical pepsin, preparation gastric juice, crystalline trypsin, highly purified chemotrypsin, highly purified trypsin, highly purified amylase which were introduced into industry. New methods of silver regeneration from photographic and cinema films with the use of proteinase of S. griseus were developed, as well as the enzyme-antibiotic preparation protezym for hydrolysis of fodder proteins which gave positive results in breeding calves and in feeding adult animals. O. S. Tsyperovich has proposed two simple structures of automatic collector of fractions for the column chromatography, published 178 scientific works including 3 monographs, 10 author's certificates; 12 candidates of science were brought up under his supervision.
authors: R P
authors: RP
authors: Vynohradova
authors: M V
authors: MV
authors: Kolodzeĭs'ka
mesh_terms: D001671:Biochemistry / Q000266:history*; D001709:Biotechnology / Q000266:history*; D004798:Enzymes / Q000138:chemical synthesis / Q000266:history; D049673:History, 20th Century; D012426:Russia
chemical_list: D004798:Enzymes