Study on fluorescence characteristics of duloxetine hydrochloride.
The fluorescence characteristics of duloxetine hydrochloride are studied in this paper. The fluorescence emission spectra of duloxetine demonstrate that intramolecular charge-transfer takes place between thiophene ring and napthalenyloxy group upon irradiation. The effects of excitation light, solvent system, variation of solution pH value, metal ions and vitamin C on the fluorescence spectra of duloxetine hydrochloride are elucidated, respectively. A spectrofluorometric method of quantitative determination of duloxetine in dosage form is reported for the first time, the linear range is 7.14 x 10(-8)mol/L to 1.43 x 10(-5)mol/L, the linear correlation coefficient r is equal to 0.9997, and the detection limit is 3.5 x 10(-8)mol/L. The accuracy and the precision are satisfactory.
Liu
Xiangping
X
Key Laboratory of Modern Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China.
Du
Yingxiang
Y
Wu
Xiulan
X
D000928:Antidepressive Agents / Q000737:chemistry; D001205:Ascorbic Acid; D002412:Cations; D000068736:Duloxetine Hydrochloride; D006863:Hydrogen-Ion Concentration; D008670:Metals; D015394:Molecular Structure; D055668:Photochemical Processes; D012997:Solvents; D013050:Spectrometry, Fluorescence; D013696:Temperature; D013876:Thiophenes / Q000737:chemistry*
D000928:Antidepressive Agents; D002412:Cations; D008670:Metals; D012997:Solvents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride; D001205:Ascorbic Acid