[Acral necrosis in metastatic ovarian carcinoma. A single episode of Moschowitz syndrome during gemcitabine chemotherapy].
For some time now, there have been reports of acral necrosis as a paraneoplasia that may occur in association with a number of different malignant tumours. There have also been a series of reports about acral necrosis associated with chemotherapy with various cytostatics. The treatment of choice if these lesions occur is plasmapheresis. Ultimately, the occurrence of thrombotic microangiopathy (TMA) can only be prevented by close monitoring through regular laboratory controls before each new cycle of chemotherapy. In the differential diagnosis, Raynaud's syndrome should be considered as a premonitory paraneoplasia, a risk factor for the occurrence of acral necrosis in patients with a malignant tumour undergoing chemotherapy, particularly patients with ovarian carcinoma receiving gemcitabine treatment.
Behne
M J
MJ
Klinik für Dermatologie und Venerologie, Universitätskrankenhaus Eppendorf, Martinistrasse 52, 20246 Hamburg, Deutschland. m.behne@uke.uni-hamburg.de
Hauswirth
U
U
Menz
A
A
Brüllke
N
N
Müllerleile
U
U
Moll
I
I
D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005385:Fingers / Q000473:pathology*; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced / Q000628:therapy; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000628:therapy*; D016896:Treatment Outcome; D000093542:Gemcitabine
D003841:Deoxycytidine; D000093542:Gemcitabine