Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester.
The aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption.
Bhandari
Krishna Hari
KH
College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
Lee
Dong Xun
DX
Newa
Madhuri
M
Yoon
Sung Il
SI
Kim
Jung Sun
JS
Kim
Dae Duk
DD
Kim
Jung-Ae
JA
Yoo
Bong Kyo
BK
Woo
Jong Soo
JS
Lyoo
Won Seok
WS
Lee
Jae Hwi
JH
Choi
Han Gon
HG
Yong
Chul Soon
CS
D000818:Animals; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004952:Esters / Q000737:chemistry / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D020910:Ketorolac / Q000737:chemistry / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008812:Mice, Hairless; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D012995:Solubility
D004952:Esters; D005227:Fatty Acids; D020910:Ketorolac