Fight or learn to live with the consequences?
Individuals can fight their infectious diseases by reducing the growth of a pathogen (resistance), but they can also ameliorate the disease it causes (tolerance). A recent paper shows that there is variation between mouse strains in tolerance to a rodent malaria and that this was negatively correlated with resistance. This is important, because tolerance has major implications for the epidemiology and coevolution of host-parasite interactions, but has been neglected in the animal literature.
Boots
Michael
M
Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, UK. m.boots@sheffield.ac.uk
D000818:Animals; D003141:Communicable Diseases / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D007113:Immunity, Innate; D051379:Mice