title: Neurogenesis directed by Sirt1.
abstract: Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
authors: Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors: Sergiy
authors: S
authors: Libert
authors: Dena
authors: D
authors: Cohen
authors: Leonard
authors: L
authors: Guarente
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000166:cytology / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000235:genetics; D051379:Mice; D009474:Neurons / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D013234:Stem Cells / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D056564:Sirtuin 1; D037761:Sirtuins; C499317:Ascl1 protein, mouse; C470545:Sirt1 protein, mouse