title: Rotavirus morbidity and mortality in children in Brazil.
abstract: OBJECTIVE
  To study the epidemiology of rotavirus and estimate rotavirus-associated morbidity and mortality in children<or=5 years of age in Brazil in 2004 before introducing the rotavirus vaccine in Brazil's National Immunization Program (Programa Nacional de Imunizações, PNI).
  
  
  METHODS
  To estimate rotavirus morbidity, published studies (1999-2006) addressing incidence of acute diarrhea among children<or=5 years of age and frequency of rotavirus infection among children with diarrhea in Brazil were reviewed. Diarrhea episodes were divided into three categories of severity by level of care: mild cases requiring only home-based care; moderate cases requiring a visit to an outpatient healthcare facility; and severe cases requiring hospitalization. To estimate rotavirus mortality, information on the number of registered deaths from diarrhea in children<or=5 years of age was obtained from the Mortality Information System (Sistema de Informação sobre Mortalidade, SIM) of Brazil's public healthcare system (Sistema Unico de Saúde, SUS) and the proportion of deaths due to rotavirus was calculated.
  
  
  RESULTS
  Rotavirus infections were estimated to cause 3,525,053 episodes of diarrhea, 655,853 visits to outpatient healthcare facilities, 92,453 hospitalizations, and 850 deaths of children<or=5 years of age each year in Brazil.
  
  
  CONCLUSIONS
  Rotavirus infections are an important cause of child morbidity and mortality in Brazil.
authors: Clínica de Moléstias Infecciosas e Parasitárias, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil. anasartori@gmail.com
authors: Ana Marli Christovam
authors: AM
authors: Sartori
authors: Joice
authors: J
authors: Valentim
authors: Patrícia Coelho
authors: PC
authors: de Soárez
authors: Hillegonda Maria Dutilh
authors: HM
authors: Novaes
mesh_terms: D001938:Brazil; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D012400:Rotavirus Infections / Q000453:epidemiology*