High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy.
Localization and targeting of depth electrodes in specific regions of the human brain is critical for accurate clinical diagnoses and treatment as well as for neuroscientific electrophysiological research. By using high-resolution magnetic resonance imaging combined with 2D computational unfolding, the authors present a method that improves electrode localization in the medial temporal lobe. This method permits visualization of electrode placements in subregions of the hippocampus and parahippocampal gyrus, allowing for greater specificity in relating electrophysiological and anatomical features in the human medial temporal lobe. Such methods may be extended to therapeutic procedures targeting specific neuronal circuitry in subfields of structures deep in the human brain.
Ekstrom
Arne
A
Center for Cognitive Neurosciences, Semel Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, California 90095-7039, USA.
Suthana
Nanthia
N
Behnke
Eric
E
Salamon
Noriko
N
Bookheimer
Susan
S
Fried
Itzhak
I
D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000628:therapy*; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*