Prognostic importance of creatine kinase and creatine kinase-MB after primary percutaneous coronary intervention for ST-elevation myocardial infarction.
BACKGROUND
Although the prognostic significance of creatine kinase (CK) and creatine kinase-MB (CK-MB) after myocardial infarction has been established after thrombolysis or no reperfusion therapy, there is limited evidence of the prognostic importance after primary percutaneous coronary intervention (PCI).


METHODS
In this prospective, observational study, individual data from all patients who survived at least 2 days after primary PCI between 1991 and 2004 in our hospital were recorded. The association between enzymatic infarct size (examined by peak CK and peak CK-MB levels, each divided into tertiles) and both left ventricular ejection fraction (LVEF) and 1-year mortality was evaluated.


RESULTS
In the study group of 4670 patients, mean peak CK was 2327 U/L (SD 2008) and mean peak CK-MB was 244 U/L (SD 208). Both increased CK and CK-MB were associated with a lower LVEF. A total of 252 patients (5.4%) died between 2 days and 1 year after admission. Both peak CK and peak CK-MB were higher in those who died. Particularly, patients in the highest tertile of either peak CK or peak CK-MB had increased mortality, whereas the differences between the lower tertiles were not significant. In 2738 patients, after multivariable analysis including LVEF, the hazard ratio for 1-year mortality in patients in the highest CK tertile was 2.28 (95% CI 1.32-3.91) and for CK-MB, 1.91 (95% CI 1.11-3.26), compared to those in the other tertiles.


CONCLUSIONS
According to this large-scale study, peak CK and peak CK-MB are comparable independent predictors of LV function and 1-year mortality in patients after primary PCI.
Nienhuis
Mark B
MB
Isala klinieken, Department of Cardiology, Zwolle, The Netherlands.
Ottervanger
Jan Paul
JP
de Boer
Menko-Jan
MJ
Dambrink
Jan-Henk E
JH
Hoorntje
Jan C A
JC
Gosselink
A T Marcel
AT
Suryapranata
Harry
H
van't Hof
Arnoud W J
AW
D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D019370:Observation; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D013318:Stroke Volume; D016019:Survival Analysis
D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form