Treatment of diabetes: a clinical update on insulin trials.
The prevalence of diabetes, along with its accompanying long-term microvascular and macrovascular complications, continues to increase. Landmark studies of both type 1 and type 2 diabetes have provided the foundations on which to investigate improved treatment strategies for type 2 diabetes. Recent evidence suggests a new paradigm for treating type 2 diabetes that adds insulin earlier in the treatment process to maintain tight glycemic control. The newer insulin analogues in combination with oral antidiabetic agents provide a viable option for improving glycemic control and preventing or delaying the occurrence of complications.
LeRoith
Derek
D
Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10024, USA. Derek.leroith@mssm.edu
D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D018450:Disease Progression; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000031:analogs & derivatives / Q000627:therapeutic use; D012307:Risk Factors
D007004:Hypoglycemic Agents; D007328:Insulin