title: Longitudinal study on the relationship between serum albumin and periodontal disease.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the relationship between periodontal disease and the general health status in community-dwelling elderly using the serum albumin concentration as a criterion index of the severity of underlying disease and nutrition.
  
  
  METHODS
  Six hundred subjects aged 70 years underwent a baseline examination. Dental examinations were carried out at baseline and once a year for 4 years. Periodontal conditions were estimated for subjects with at least one remaining tooth. Clinical attachment levels at six sites of all teeth present were measured. A change in loss of attachment of 3 mm or greater in 1 year at each site was defined as periodontal disease progression. Data were analysed in subjects for whom data were available for 4 years.
  
  
  RESULTS
  Serum albumin concentration at baseline ranged from 3.4 to 5.0 g/dl with a mean of 4.3+/-0.2. When the analysis was stratified by smoking status, we found that serum albumin concentration had a significant effect on periodontal disease progression among non-smokers (standardized regression coefficient=-0.16; p=0.017), using multiple regression analysis.
  
  
  CONCLUSIONS
  The findings of the present study suggest that serum albumin concentration is a significant risk predictor of periodontal disease progression among elderly non-smokers.
authors: Department of Oral Health Science, Division of Preventive Dentistry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. masanori@dent.niigata-u.ac.jp
authors: Masanori
authors: M
authors: Iwasaki
authors: Akihiro
authors: A
authors: Yoshihara
authors: Toshinobu
authors: T
authors: Hirotomi
authors: Hiroshi
authors: H
authors: Ogawa
authors: Nobuhiro
authors: N
authors: Hanada
authors: Hideo
authors: H
authors: Miyazaki
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009752:Nutritional Status; D017622:Periodontal Attachment Loss / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*; D012907:Smoking
chemical_list: D012709:Serum Albumin