Balamuthia mandrillaris resistance to hostile conditions.
The resistance of Balamuthia mandrillaris to physical, chemical and radiological conditions was tested. Following treatments, viability was determined by culturing amoebae on human brain microvascular endothelial cells for up to 12 days. B. mandrillaris cysts were resistant to repeated freeze-thawing (five times), temperatures of up to 70 degrees C, 0.5 % SDS, 25 p.p.m. chlorine, 10 microg pentamidine isethionate ml(-1) and 200 mJ UV irradiation cm(-2).
Siddiqui
Ruqaiyyah
R
School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK.
Ortega-Rivas
Antonio
A
Department of Parasitology, La Laguna University, La Laguna, Canary Islands, Spain.
Khan
Naveed Ahmed
NA
School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK.
D000818:Animals; D001921:Brain / Q000098:blood supply; D002478:Cells, Cultured; D002713:Chlorine / Q000494:pharmacology; D042783:Endothelial Cells / Q000469:parasitology; D004730:Endothelium, Vascular / Q000166:cytology / Q000469:parasitology; D005615:Freezing; D018869:Heat-Shock Response; D006358:Hot Temperature; D006801:Humans; D016840:Lobosea / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D010419:Pentamidine / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D053058:Trophozoites / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D014466:Ultraviolet Rays
D012967:Sodium Dodecyl Sulfate; D002713:Chlorine; D010419:Pentamidine