Defining the pathways of early adult hematopoiesis.
The journeys that hematopoietic cells take to differentiate from long-term stem cells into committed cells have recently been a topic of debate. In this issue of Cell Stem Cell, Arinobu et al. (2007) and Pronk et al. (2007) provide new insights into the paths traveled by hematopoietic progenitors.
Murre
Cornelis
C
Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92903, USA. cmurre@ucsd.edu
D000818:Animals; D019070:Cell Lineage; D015672:Erythroid Precursor Cells / Q000166:cytology; D050982:GATA1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D023461:Myeloid Progenitor Cells / Q000166:cytology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics; D000099232:Proto-Oncogene Protein Spi-1
D050982:GATA1 Transcription Factor; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1