title: CDH11 expression is associated with survival in patients with osteosarcoma.
abstract: Previous studies have shown that cadherin-11 (CDH11) may be involved in the metastatic process of osteosarcoma. The correlation of the expression levels of CDH11 in osteosarcoma samples with the risk of disease progression and metastasis was examined. Real time qRT-PCR was used to quantify CDH11 expression in a set of newly established osteosarcoma cell lines, 11 primaries and five metastases, compared to the levels in 12 normal osteoblast cell lines established from healthy bone, and also in a set of 10 snap-frozen osteosarcoma samples. In all cases long term clinical follow-up data was available. The CDH11 expression level decreased gradually from the osteoblast to the primary cell lines (p=0.2184) and further to those established from the tumor metastases (p=0.0275). Importantly, the level of CDH11 expression correlated significantly (p=0.01) with patient survival (Kaplan-Meier survival analysis) in both sample sets (p=0.0128 for the cell lines, p=0.0492 for the biopsies). In conclusion, the results indicate that CDH11 may be useful as a prognostic marker of disease progression and survival in osteosarcoma.
authors: Cancer Genomics Laboratory, Mitchell Cancer Institute, Mobile, AL 36688, USA.
authors: Go
authors: G
authors: Nakajima
authors: Ana
authors: A
authors: Patino-Garcia
authors: Skjalg
authors: S
authors: Bruheim
authors: Yaguang
authors: Y
authors: Xi
authors: Mikel
authors: M
authors: San Julian
authors: Fernando
authors: F
authors: Lecanda
authors: Luis
authors: L
authors: Sierrasesumaga
authors: Christoph
authors: C
authors: Müller
authors: Oystein
authors: O
authors: Fodstad
authors: Jingfang
authors: J
authors: Ju
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism / Q000401:mortality*; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000235:genetics / Q000378:metabolism / Q000401:mortality*; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D012333:RNA, Messenger; C086960:osteoblast cadherin