title: [The molecular-genetic study of juvenile endogenous attack-like psychoses].
abstract: Polymorphisms of the following genes (dopamine receptors D2 (Taq1A), D3 (Ser/Glu), D4 (VNTR, -521T/C, -616 G/C, -809A/G), catechol-O-methyltransferase, serotonin receptor type 2A (T102C), serotonin transporter (5-HTTLPR small i, Cyrillic VNTR) and brain-derived neurotrophic factor) have been studied in 260 men with juvenile endogenous attack-like psychoses and 145 age- and sex-matched controls. Type of psychopathological syndrome, PANSS scores and cognitive traits have been assessed. Only the T102C 5-HTR2A polymorphism was associated with some changes in the progress of this type of psychosis. As compared to the TT genotype, patients with 1 or 2 copies of the C allele were characterized by the absence of or less pronounced affective symptoms and more cognitive impairment that implies severity of illness. Moreover, the higher frequency of the C allele was found in the group of patients with chronic course of disease. In conclusion, the T102C polymorphism can be taken into account in prediction of juvenile endogenous attack-like psychosis.
authors: V E
authors: VE
authors: Golimbet
authors: V G
authors: VG
authors: Kaleda
authors: M V
authors: MV
authors: Alfimova
authors: G I
authors: GI
authors: Korovaĭtseva
authors: O M
authors: OM
authors: Lavrushina
authors: A N
authors: AN
authors: Barkhatova
authors: S V
authors: SV
authors: Kasparov
authors: N V
authors: NV
authors: Ivanova
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics*; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics* / Q000378:metabolism
chemical_list: D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D004247:DNA