MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype.
Dengue disease can clinically evolve from an asymptomatic and mild disease, known as dengue fever (DF), to a severe disease known as dengue hemorrhagic fever (DHF). Recent evidence has shown how host genetic factors can be correlated with severe dengue susceptibility or protection. Many of these genes, such as CD209, TNF-a, vitamin D receptor, and FC gamma receptor IIA, are components of the innate immune system, suggesting that innate responses might have a role in dengue pathogenesis. MBL2 gene polymorphisms have been shown to modulate susceptibility or protection in many viral diseases. We investigated the involvement of MBL2 gene in the dengue clinical outcome through the analysis of MBL2 exon 1 polymorphisms (at codons 52, 54, and 57) known to be associated with reduced serum levels of the MBL protein. The genotypes of 110 well-characterized dengue-positive patients were statistically analyzed to establish possible correlations between MBL2 polymorphisms and parameters such as sex, type of infection (primary or secondary response), race/ethnicity, course of infection, and age. We found significant correlations between wild-type AA MBL2 genotype and age as associated risk factors for development of dengue-related thrombocytopenia.
Acioli-Santos
Bartolomeu
B
Virology and Experimental Therapy Laboratory, Aggeu Magalhães Research Center-CPqAM/FIOCRUZ, Recife, Brazil.
Segat
Ludovica
L
Dhalia
Rafael
R
Brito
Carlos A A
CA
Braga-Neto
Ulisses M
UM
Marques
Ernesto T A
ET
Crovella
Sergio
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001938:Brazil; D003715:Dengue / Q000097:blood / Q000235:genetics*; D003716:Dengue Virus; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D019595:Severe Dengue / Q000097:blood / Q000235:genetics*; D013921:Thrombocytopenia / Q000235:genetics*
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin