Anaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization.
Methotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy for ALL. A desensitization protocol was followed and MTX tolerance has been successfully achieved, allowing this patient to complete the needed chemotherapy.
Caldeira
Teresa
T
Department of Paediatrics, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal.
Costa
Vitor
V
Silva
Isabel
I
Oliva
Tereza
T
Norton
Lucília
L
D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects*; D002648:Child; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000628:therapy*; D006801:Humans; D007278:Injections, Spinal; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate