title: Is minimally invasive harvesting of the great saphenous vein for coronary artery bypass surgery a cost-effective technique?
abstract: OBJECTIVE
  In this study we aim to assess the cost-effectiveness analysis of minimally invasive vein harvesting. The great saphenous vein is the most commonly used conduit in coronary artery bypass surgery. In the past decade minimally invasive techniques have been developed to reduce the surgical trauma associated with the conventional open vein-harvesting technique. There is strong evidence to suggest that minimally invasive harvesting can reduce postoperative wound healing complications, pain, mobility restriction, and hospital stay. Despite the increasingly widespread use of this technique, formal cost-effectiveness analysis has never been performed.
  
  
  METHODS
  Economic analysis was performed according to the National Institute of Healthcare and Clinical Excellence guidelines on the evaluation of technology by using published data on postoperative pain and mobility restriction, locally collected data, National Health Service reference costs, and manufacturer's data. Probabilistic sensitivity analysis was performed to investigate and quantify the uncertainty associated with the results of our analysis.
  
  
  RESULTS
  The results of our analysis demonstrate that minimally invasive vein harvesting was more cost-effective, with an incremental cost-effectiveness ratio of $19,858.87/quality-adjusted life year (QALY), comparing favorably with other health care interventions. Probabilistic sensitivity analysis demonstrated with 95.6% certainty that endoscopic harvesting was more cost-effective at a willingness-to-pay threshold of $50,000/quality-adjusted life year. Alternative analysis suggested that even with considerable uncertainty associated with quality of life after vein harvesting, minimally invasive harvesting was more cost-effective than conventional vein harvesting.
  
  
  CONCLUSIONS
  Minimally invasive harvesting is the most cost-effective method of harvesting the great saphenous vein and can significantly improve a patient's quality of life.
authors: Department of Biosurgery and Surgical Technology, Imperial College London, London, United Kingdom.
authors: Christopher
authors: C
authors: Rao
authors: Omer
authors: O
authors: Aziz
authors: Samer
authors: S
authors: Deeba
authors: Andre
authors: A
authors: Chow
authors: Catherine
authors: C
authors: Jones
authors: Zhifang
authors: Z
authors: Ni
authors: Leonidas
authors: L
authors: Papastavrou
authors: Shamim
authors: S
authors: Rahman
authors: Ara
authors: A
authors: Darzi
authors: Thanos
authors: T
authors: Athanasiou
mesh_terms: D001026:Coronary Artery Bypass / Q000191:economics*; D003362:Cost-Benefit Analysis; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000191:economics*; D009010:Monte Carlo Method; D011788:Quality of Life; D012501:Saphenous Vein / Q000601:surgery / Q000637:transplantation*; D020858:Tissue and Organ Harvesting / Q000191:economics*