title: N-D-aldopentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives: potential anti-TB therapeutic agents.
abstract: Thiocarlide (THC; N,N'-bis[p-(isoamyloxy)phenyl]-thiourea; also known as isoxyl) has been used in the past as anti-tuberculosis agent. In an effort to improve the therapeutic value of THC several N-pentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives were synthesized by coupling of an aniline derivative and pentofuranosyl isothiocyanates. The MIC values of the new products against M.tb indicate that this new approach to the synthesis of potential anti-TB therapeutic agents was successful.
authors: Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA. avraham.liav@colostate.edu
authors: Avraham
authors: A
authors: Liav
authors: Shiva K
authors: SK
authors: Angala
authors: Patrick J
authors: PJ
authors: Brennan
authors: Mary
authors: M
authors: Jackson
mesh_terms: D000586:Amination; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010100:Oxygen / Q000737:chemistry*; D019800:Phenol / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000995:Antitubercular Agents; D019800:Phenol; D013890:Thiourea; D010100:Oxygen