[Preparation of tablets containing enteric-coated diclofenac sodium pellets].
Fluidized-bed manufactured enteric-coated diclofenac sodium pellets were compressed into tablets. The blend of two aqueous acrylic resins dispersion in different ratios, Eudragit NE30D and Eudragit L30D-55, were used to prepare enteric-coated diclofenac sodium pellets of different particle sizes and coating level. The cushioning pellets with different properties and these enteric-coated pellets were compressed into tablets in different proportions. The drug release of the tablets containing these pellets would be lower than 10% in 2 h in simulated gastric fluid, but reach (83 +/- 2.42)% in 1 h in simulated enteric fluid. The mixture of Eudragit NE30D and Eudragit L30D-55 could be used to prepare enteric pellets which are suitable for compression. The cushioning pellets which were composed of stearic acid/microcrystalline cellulose (4:1, w/w) could avoid rupture of the coating of pellets during the compression.
Qi
Xiao-Le
XL
Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210038, China.
Zhu
Jia-Bi
JB
Chen
Sheng-Jun
SJ
D000180:Acrylic Resins / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002482:Cellulose / Q000737:chemistry; D004008:Diclofenac / Q000138:chemical synthesis*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D008689:Methacrylates / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013608:Tablets, Enteric-Coated / Q000737:chemistry*
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; C477852:Eudragit L 30 D-55; D008689:Methacrylates; D011108:Polymers; D013608:Tablets, Enteric-Coated; D004008:Diclofenac; D002482:Cellulose; C109691:microcrystalline cellulose