Absidia corymbifera fungal infection in burns: a case report and review of the literature.
Fungal infection in burn wounds can be difficult to diagnose and manage. A previously reported 10-year experience in burns patients confirms that although a marked decline has occurred in bacterial infection, fungal wound infection rates remain unaffected. Moreover, there is significant morbidity and mortality associated with fungal infections in patients with extensive burns. Absidia corymbifera is a saprophytic organism, with worldwide distribution, that is primarily isolated from soil as well as decaying vegetation and grass. It is an uncommon pathogen representing only 2 to 3% of all zygomycete infections in humans. The organism is opportunistic, rarely infecting the immunocompetent although such cases have been reported. To our knowledge, there are only two prior reports of A. corymbifera in burns patients. The ability to invade intact skin through proteolytic enzymes as well as the organism's angioinvasive propensity is associated with high mortality and demands a multidisciplinary approach. We present a case report of A. corymbifera infection in a burns patient and review the current literature.
Constantinides
Joannis
J
West Midlands Regional Burns Service, University Hospital Birmingham NHS Foundation Trust, Selly Oak Hospital, Birmingham, UK.
Misra
Alok
A
Nassab
Reza
R
Wilson
Yvonne
Y
D020095:Absidia / Q000302:isolation & purification*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002056:Burns / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D012307:Risk Factors
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B