Why myc? An unexpected ingredient in the stem cell cocktail.
Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.
Knoepfler
Paul S
PS
Institute of Pediatric Regenerative Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA. knoepfler@ucdavis.edu
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D004622:Embryo, Mammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D039904:Pluripotent Stem Cells / Q000502:physiology; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D044968:Regenerative Medicine; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology*
D018797:Cell Cycle Proteins; C000715470:MAS1 protein, human; D050814:Octamer Transcription Factor-3; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc; D055748:SOXB1 Transcription Factors; D050796:STAT3 Transcription Factor