Novel agents for intractable itch.
There exists a multitude of medical conditions that cause intractable itch, or pruritus. The successful management of this symptom depends explicitly on establishing the underlying cause. Studies have shown that drugs not traditionally used in the treatment of cutaneous disorders, such as opiate receptor antagonists, antidepressants, and antiepileptics, can provide symptomatic relief of intractable itch. These novel antipruritic agents will be explored in this review.
Lynde
C B
CB
Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Kraft
J N
JN
Lynde
C W
CW
D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000982:Antipruritics / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D009292:Narcotic Antagonists / Q000627:therapeutic use; D010789:Phototherapy; D011537:Pruritus / Q000628:therapy*
D000927:Anticonvulsants; D000928:Antidepressive Agents; D000982:Antipruritics; D006634:Histamine H1 Antagonists; D009292:Narcotic Antagonists