Quo vadis brain repair? A long axonal journey in the adult CNS.
Recently in Nature Neuroscience, Gaillard et al. (2007) study axonal projections from embryonic cortical explants grafted into acutely damaged adult motor cortex. After attempting to rule out fusion of donor tissue with pre-existing host circuitry, the authors report robust long-distance donor axonal projections and synaptic integration into target regions appropriate for the motor system.
Singec
Ilyas
I
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. isingec@burnham.org
Snyder
Evan Y
EY
D000328:Adult; D000818:Animals; D001369:Axons / Q000378:metabolism*; D001930:Brain Injuries / Q000473:pathology*; D016380:Brain Tissue Transplantation; D002490:Central Nervous System / Q000473:pathology*; D006801:Humans; D051379:Mice; D009474:Neurons; D013234:Stem Cells; D014945:Wound Healing