Development of a differential pulse voltammetric method for the determination of Silymarin/Vitamin E acetate mixture in pharmaceuticals.
Differential pulse voltammetric method was developed for determination of Silymarin (SMR)/Vitamin E acetate (VEA) mixture in pharmaceuticals. SMR and VE gave well-resolved diffusion-controlled anodic peaks at +756 and +444mV, respectively (versus Ag/AgCl) in Britton-Robinson buffer at pH 2.8. The solution conditions and instrumental parameters were optimized for their quantitative determination. The linear response was obtained in the range 0.1-4.0mgL(-1) with a detection limit of 0.03mgL(-1) for SMR and 0.05-4.0mgL(-1) with a detection limit of 0.01mgL(-1)for VEA.
Hassan
Ekram M
EM
Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria 21521, Egypt. ekram_mahm@yahoo.com
Khamis
Essam F
EF
El-Kimary
Eman I
EI
Barary
Magda A
MA
D002138:Calibration; D004563:Electrochemistry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012838:Silymarin / Q000032:analysis*; D014810:Vitamin E / Q000032:analysis*
D004364:Pharmaceutical Preparations; D012838:Silymarin; D014810:Vitamin E