title: Cibenzoline intoxication: effect of combined hemoperfusion-hemodialysis on plasma clearance.
abstract: BACKGROUND
  Cibenzoline is an antiarrhythmic drug used to treat patients with supraventricular or ventricular arrhythmias. Cibenzoline overdose is associated with proarrhythmic and hemodynamic effects such as hypotension and congestive heart failure.
  
  
  METHODS
  We report a case of cardiogenic shock due to cibenzoline overdose in a patient with progressive renal insufficiency.
  
  
  CONCLUSIONS
  The standard treatment of a cibenzoline intoxication is symptomatic, but we used combined hemoperfusion-hemodialysis to treat our patient.
  
  
  CONCLUSIONS
  This was associated with a rapid decline in plasma cibenzoline concentration and improvement of the clinical condition. However, only 28.98 mg of an estimated body pool of cibenzoline (447.2 to 806.6 mg) was removed during the 8 hours of treatment.
authors: Department of Critical Care Medicine, University Hospital of Antwerp, Edegem, Belgium.
authors: Roel
authors: R
authors: Meeus
authors: Gert A
authors: GA
authors: Verpooten
authors: Rudi
authors: R
authors: De Paep
authors: Bernard P
authors: BP
authors: Paelinck
authors: Hugo
authors: H
authors: Neels
authors: Sarah
authors: S
authors: Cooreman
authors: Mireiile
authors: M
authors: De Doncker
authors: Philippe G
authors: PG
authors: Jorens
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D001281:Atrial Fibrillation / Q000188:drug therapy; D062787:Drug Overdose; D005260:Female; D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D007674:Kidney Diseases / Q000139:chemically induced* / Q000628:therapy; D006435:Renal Dialysis; D051437:Renal Insufficiency; D012770:Shock, Cardiogenic / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; C032151:cifenline