A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid.
Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.
Amos
Ruth I J
RI
School of Chemistry, University of Tasmania, Private Bag 75, Hobart, Tasmania 7001, Australia. .
Gourlay
Brendon S
BS
Schiesser
Carl H
CH
Smith
Jason A
JA
Yates
Brian F
BF
D000995:Antitubercular Agents / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D007538:Isoniazid / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000995:Antitubercular Agents; D006834:Hydrazines; D007538:Isoniazid