[Second pregnancies in HIV-1-infected women. A prospective monocentric study].
OBJECTIVE
To evaluate the influence of successive pregnancies on the materno-foetal prognosis in a population of HIV-infected women. Clinical, biological data and treatment strategies were compared during iterative pregnancies.


METHODS
We conducted a monocentric prospective study between August 1995 and January 2007 in a French university hospital (Nice).


RESULTS
Twenty-six HIV-infected women had two consecutive pregnancies during our study. We noticed an increase in CD4 cell count between the two pregnancies. Viral load variations were non significant. The maternal's prophylaxis changed. Percentage of HAART increased from 26 to 54%. Modes of delivery, HIV or treatments side-effects remained the same between the successive pregnancies.


CONCLUSIONS
Successive pregnancies do not seem to influence the materno-foetal prognosis related to HIV infection.
Monpoux
F
F
Service de pédiatrie, hôpital de l'Archet-2, 151, route de Saint-Antoine-de-Ginestière, B.P. 3079, 06202 Nice cedex 3, France. monpoux.f@chu-nic.fr
Delotte
J
J
Galiba
E
E
de Smet
S
S
Durant
J
J
Boutté
P
P
Bongain
A
A
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002585:Cesarean Section; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000401:mortality / Q000635:transmission; D015497:HIV-1; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D011256:Pregnancy Outcome; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D019562:Viral Load