Synthesis of novel analogues of (+)-varitriol via olefin cross-metathesis reaction.
Novel analogues of (+)-varitriol have been synthesized via olefin cross-metathesis reaction using Grubb's catalyst. Newly synthesized compounds were screened for cytotoxicity and they showed mild activity against RAW264.7 and HT29 cell lines.
Nagarapu
Lingaiah
L
Organic Chemistry Division-II, Indian Institute of Chemical Technology (IICT), FCL Ist Floor, Taranaka, Hyderabad, Andhra Pradhesh 500 607, India. nagarapu2@yahoo.co.in
Paparaju
Venkateswarlu
V
Satyender
Apuri
A
D000475:Alkenes / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D001592:Benzyl Alcohols / Q000138:chemical synthesis*; D002384:Catalysis; D002460:Cell Line / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis*; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008956:Models, Chemical; D013237:Stereoisomerism
D000475:Alkenes; D000970:Antineoplastic Agents; D001592:Benzyl Alcohols; D003432:Cross-Linking Reagents; D005663:Furans; C456047:varitriol