Staying alive: bacterial inhibition of apoptosis during infection.
The ability of bacterial pathogens to inhibit apoptosis in eukaryotic cells during infection is an emerging theme in the study of bacterial pathogenesis. Prevention of apoptosis provides a survival advantage because it enables the bacteria to replicate inside host cells. Bacterial pathogens have evolved several ways to prevent apoptosis by protecting the mitochondria and preventing cytochrome c release, by activating cell survival pathways, or by preventing caspase activation. This review summarizes the most recent work on bacterial anti-apoptotic strategies and suggests new research that is necessary to advance the field.
Faherty
Christina S
CS
Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA.
Maurelli
Anthony T
AT
D000818:Animals; D017209:Apoptosis; D001419:Bacteria / Q000254:growth & development* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D002460:Cell Line; D045304:Cytochromes c / Q000037:antagonists & inhibitors / Q000378:metabolism; D005057:Eukaryotic Cells / Q000382:microbiology* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D051381:Rats
D061945:Caspase Inhibitors; D045304:Cytochromes c; D020169:Caspases