title: Investigation of the permeability characteristics of peri-ulcer and whole ischaemic skin tissue.
abstract: Excessive wound exudate in chronic wounds can cause skin maceration to occur around a wound, which may delay healing and lead to other complications. In order to assess possible treatment options with topical therapy there is a need to characterize the permeability of wound and peri-ulcer tissue. Previously we have reported the permeability of a range of chemicals with differing physicochemical properties in human ulcerated and peri-ulcer ischaemic tissue. The findings suggested that wound tissue and peri-ulcer tissue were not representative of normally functioning skin barriers. In the present work we have investigated the permeability of tritiated water in peri-ulcer and whole skin human tissue obtained from clinically diagnosed diabetic ischaemic patients. Permeability data for peri-ulcer tissue was generally higher and more variable than for normal tissue. Histological examination confirmed the breakdown of the skin tissue in the peri-ulcer area and also in the normal skin tissue samples taken from diabetic ischaemic patients. The impaired skin barrier function both in the peri-ulcer and normal tissue may offer opportunities for dermal and transdermal therapies for management of diabetes-related complications.
authors: ConvaTec Wound Therapeutics, Global Development Centre, 1st Avenue, Deeside Industrial Park, Deeside, Flintshire CH5 2NU, UK.
authors: Mike
authors: M
authors: Walker
authors: Jonathan
authors: J
authors: Hadgraft
authors: Majella E
authors: ME
authors: Lane
mesh_terms: D000368:Aged; D003627:Data Interpretation, Statistical; D003925:Diabetic Angiopathies / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007511:Ischemia / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000098:blood supply*; D012869:Skin Absorption / Q000502:physiology*; D012883:Skin Ulcer / Q000378:metabolism / Q000473:pathology*