New approaches to therapy with omega-3 fatty acids.
With greater focus on chronic disease prevention, renewed attention has been directed toward understanding the pathophysiology of various medical conditions and the development of newer medical treatments to prevent and treat complications. There has been immense interest in evaluating societal lifestyles, cultural attitudes toward health, and dietary influences on health conditions. The omega-3 fatty acids have become a focus of interest, and recent research and trial evidence have highlighted their effects, including potential clinical advantages. Despite this progress, the precise mechanisms through which omega-3 fatty acids act remain poorly understood. These agents are now recommended as secondary prevention after acute myocardial infarction, and ongoing large clinical trials should provide insight into the use of omega-3 fatty acids in heart failure and the primary prevention of cardiovascular disease.
Kakar
Puneet
P
University Department of Medicine, City Hospital, Birmingham B18 7QH, UK. g.y.h.lip@bham.ac.uk
Watson
Timothy
T
Lip
Gregory Y H
GY
D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001792:Blood Platelets / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control; D015815:Cell Adhesion Molecules / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000627:therapeutic use*; D005342:Fibrinolysis / Q000187:drug effects; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D009203:Myocardial Infarction / Q000517:prevention & control; D010938:Plant Oils / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000517:prevention & control; D016019:Survival Analysis
D015815:Cell Adhesion Molecules; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010938:Plant Oils