[Correlation of aquaporin 1 with hypoxia-inducible factor 1 in breast cancer].
OBJECTIVE
To determinate the correlation of aquaporin 1 (AQP1) and hypoxia-inducible 1 (HIF-1).


METHODS
155 samples of breast cancer obtained during radical mastectomy underwent immunohistochemistry to detect the expression of AQP1 and HIF-1.


RESULTS
The positive rates of AQP1 in the HIF1 positive group was 297 +/- 25, significantly higher than that of HIF1 negative group (168 +/- 38, P < 0.001).


CONCLUSIONS
AQP1 is positively correlated with HIF1. The interaction of AQP1 and HIF1 may co-regulate the progress of breast cancer.
Yin
Tie-Jun
TJ
Department of Comprehensive Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. tjyin@tjh.tjmu.edu.cn
Yu
Shi-Ying
SY
Xiao
Liang
L
Zhang
Jun
J
Liu
Chong
C
Lu
Yun-Ping
YP
Liu
Cheng-Ping
CP
D000328:Adult; D000368:Aged; D051398:Aquaporin 1 / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008408:Mastectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D055815:Young Adult
C496020:AQP1 protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051398:Aquaporin 1