DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy.
Protozoan parasites of the genus Leishmania cause severe diseases that threaten human beings, both for the high mortality rates involved and the economic loss resulting from morbidity, primarily in the tropical and subtropical areas. This ancient eukaryote shows variable genetic diversity in their life cycle, wherein DNA topoisomerases play a key role in cellular processes affecting the topology and organization ofintracellular DNA. Kinetoplastid topoisomerases offer most attractive targets for their structural diversity from other eukaryotic counterparts and their indispensable function in cell biology Therefore, understanding the biology of kinetoplastid topoisomerases and the components and steps involved in this intricate process provide opportunities for target based drug designing against protozoan parasitic diseases.
Das
Benu Brata
BB
Department of Molecular Parasitology, Indian Institute of Chemical Biology Kolkata, India.
Ganguly
Agneyo
A
Majumder
Hemanta K
HK
D000818:Animals; D026942:DNA Topoisomerases / Q000145:classification; D016503:Drug Delivery Systems; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007891:Leishmania / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D007896:Leishmaniasis / Q000188:drug therapy* / Q000201:enzymology / Q000469:parasitology; D015800:Protozoan Proteins / Q000187:drug effects / Q000235:genetics; D059003:Topoisomerase Inhibitors; D014344:Trypanocidal Agents / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D015800:Protozoan Proteins; D059003:Topoisomerase Inhibitors; D014344:Trypanocidal Agents; D026942:DNA Topoisomerases