Pharmacokinetics and toxicity of zonisamide in cats.
With the eventual goal of making zonisamide (ZNS), a relatively new antiepileptic drug, available for the treatment of epilepsy in cats, the pharmacokinetics after a single oral administration at 10mg/kg and the toxicity after 9-week daily administration of 20mg/kg/day of ZNS were studied in healthy cats. Pharmacokinetic parameters obtained with a single administration of ZNS at 10mg/day were as follows: Cmax=13.1microg/ml; Tmax=4.0h; T(1/2)=33.0h; areas under the curves (AUCs)=720.3microg/mlh (values represent the medians). The study with daily administrations revealed that the toxicity of ZNS was comparatively low in cats, suggesting that it may be an available drug for cats. However, half of the cats that were administered 20mg/kg/day daily showed adverse reactions such as anorexia, diarrhoea, vomiting, somnolence and locomotor ataxia.
Hasegawa
Daisuke
D
Department of Veterinary Radiology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan. disk-hsgw@nvlu.ac.jp
Kobayashi
Masanori
M
Kuwabara
Takayuki
T
Ohmura
Tomoyuki
T
Fujita
Michio
M
Orima
Hiromitsu
H
D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000633:toxicity; D019540:Area Under Curve; D001682:Biological Availability; D002371:Cat Diseases / Q000097:blood / Q000139:chemically induced*; D002415:Cats / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007555:Isoxazoles / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000633:toxicity; D008297:Male; D008657:Metabolic Clearance Rate; D000078305:Zonisamide
D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide