Linking cohesin to gene regulation.
During cell division the cohesin complex mediates the pairing of sister chromatids. Emerging evidence shows that cohesin also has roles in interphase cells. New studies, including that of Gullerova and Proudfoot (2008) in this issue, reveal how cohesin is targeted to specific sites on chromosomes and implicate cohesin in the regulation of gene expression.
Peric-Hupkes
Daniel
D
Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
van Steensel
Bas
B
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D009687:Nuclear Proteins / Q000378:metabolism*; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D000097722:Cohesins