title: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: a case report.
abstract: Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of the BRAFVK600-1E mutation, the molecular hallmark of the solid variant of PTC. Histological and molecular evaluation of the surgical specimen confirmed this pre-operative diagnosis. Thus combining cytology to BRAF molecular analysis is useful to refine the cytological diagnosis of this variant also on FNC specimens.
authors: Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli studi di Napoli Federico II, 80131 Naples, Italy. giancarlo.troncone@unina.it
authors: Giancarlo
authors: G
authors: Troncone
authors: Maria
authors: M
authors: Russo
authors: Umberto
authors: U
authors: Malapelle
authors: Marina
authors: M
authors: Accardo
authors: Angelo
authors: A
authors: Ferraro
authors: Immacolata
authors: I
authors: Cozzolino
authors: Lucio
authors: L
authors: Palombini