title: [The influence of Helicobacter pylori infection on the occurance of gastroesophageal reflux in patients with renal insufficiency].
abstract: OBJECTIVE
  Gastric acid is a key factor in the pathophysiology of gastroesophageal reflux disease. A plausible mechanism by which the Helicobacter pylori infection might protect against reflux disease is by its propensity to produce atrophic gastritis. The aim of the study was to establish the influence of Helicobacter pylori infection on the occurrence of gastroesophageal reflux in patients with different stages of renal insufficiency.
  
  
  METHODS
  The examination was organized as a prospective, clinical study and involved 68 patients--33 patients with preterminal stage of renal failure and 35 patients with terminal renal insufficiency. Due to dyspeptic difficulties, in all the patients there was preformed upper esophagogastroscopy and Helicobacter pylori infection was found by ureasa test.
  
  
  RESULTS
  The patients with preterminal renal insufficiency were significantly younger than patients with terminal renal failure (53.4 +/- 11.1 vs. 65.4 +/- 12.3 years; p = 0.014). There was found a statistically significant difference between the groups in Helicobacter pylori infection (p = 0.03), hiatal hernia (p = 0.008), gastroesophageal reflux disease (p = 0.007), and duodenal ulcer (p = 0.002). Using the multiple non-parametric correlative analysis there was confirmed a negative correlation between Helicobacter pylori infection and gastro-esophageal reflux disease (Kendal tauB = -0.523; p = 0.003) and hiatal hernia (Kendal tauB = 0.403; p = 0.021), while there was found a positive correlation between gastro-esophageal reflux disease and hiatal hernia (Kendal tauB = 0.350; p = 0.044).
  
  
  CONCLUSIONS
  Helicobacter pylori infection is a significant protective parameter of the incidence of gastro-esophageal reflux disease in patients with both pre-terminal and terminal renal insufficiency.
authors: Medicinski fakultet, Interna klinika, Kragujevac, Srbija. radsto@ptt.yu
authors: Radojica
authors: R
authors: Stolić
authors: Aleksandar
authors: A
authors: Jovanović
authors: Vladan
authors: V
authors: Perić
authors: Goran
authors: G
authors: Trajković
authors: Ziva
authors: Z
authors: Zivić
authors: Dragica
authors: D
authors: Stolić
authors: Tatjana
authors: T
authors: Lazarević
authors: Sasa
authors: S
authors: Sovtić
mesh_terms: D000368:Aged; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications* / Q000382:microbiology