Acylated triterpenoid saponins from Schima noronhae and their cell growth inhibitory activity.
Two new acylated triterpenoid saponins were isolated from the branches of Schima noronhae by bioassay-guided purification. Their chemical structures were established on the basis of spectroscopic analysis and chemical means as 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucuronopyranosyl 22-O-angeloyl-A1-barrigenol (1) and 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucuronopyranosyl 22-O-angeloylerythrodiol (2). Compounds 1 and 2 showed cell growth inhibitory activity against both HeLa and DLD1 cells at a concentration of less than 10 microM.
Ohtsuki
Takashi
T
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Miyagawa
Takashi
T
Koyano
Takashi
T
Kowithayakorn
Thaworn
T
Kawahara
Nobuo
N
Goda
Yukihiro
Y
Ishibashi
Masami
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013785:Thailand; D028242:Theaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C530245:3-O-alpha-L-rhamnopyranosyl-(1-4)-beta-D-galactopyranosyl-(1-3)-(beta-D-glucopyranosyl-(1-2))-beta-D-glucuronopyranosyl 22-O-angeloyl-A1-barrigenol; C530246:3-O-alpha-rhamnopyranosyl-(1-4)-beta-D-galactopyranosyl-(1-3)-(beta-D-glucopyranosyl-(1-2))-beta-D-glucuronopyranosyl 22-O-angeloylerythrodiol; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes