title: [Opsoclonus-myoclonus syndrome in children].
abstract: To study clinical peculiarities of parainfectious opsoclonus-myoclonus syndrome (OMS) in children and to elaborate approaches to its pharmacotherapeutic correction, 20 children, including 12 girls and 8 boys, have been examined using neurological, neurophysiological, immunological and virological methods along with magnetic resonance tomography (MRT). Age-at-disease-onset was from 8 months to 3 years old. The development of neurological symptoms was related to a virus infection (55% of cases) or vaccination (15%). Marked disease seasonality (autumn, spring) was observed. In some cases, a possible role of infectious factor in the disease development was confirmed by virological and immunological studies. OMS was featured by the absence of specific brain MRT changes and low frequency of significant abnormalities of cerebrospinal fluid. A positive experience of the use of hormonal therapy and immunomodulators is presented.
authors: R Ts
authors: RTs
authors: Bembeeva
authors: A S
authors: AS
authors: Petrukhin
authors: A A
authors: AA
authors: Bologov
authors: L V
authors: LV
authors: Baĭdun
authors: E S
authors: ES
authors: Il'ina
authors: M V
authors: MV
authors: Samoĭlova
authors: L M
authors: LM
authors: Kolpachki
authors: L I
authors: LI
authors: Semykina
authors: I D
authors: ID
authors: Fedoniuk
mesh_terms: D017668:Age of Onset; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D015994:Incidence; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D053578:Opsoclonus-Myoclonus Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D011379:Prognosis; D012426:Russia / Q000453:epidemiology; D012720:Severity of Illness Index
chemical_list: D005938:Glucocorticoids; D007155:Immunologic Factors