The Cid1 poly(U) polymerase.
The Schizosaccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets. This RNA uridylation pathway appears to be conserved, as Cid1 orthologs in Arabidopsis thaliana, Caenorhabditis elegans and humans display PUP activity either in vitro or in Xenopus laevis oocytes. Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation.
Rissland
Olivia S
OS
Sir William Dunn School of Pathology, University of Oxford, UK.
Norbury
Chris J
CJ
D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000235:genetics / Q000378:metabolism*; D011072:Poly U / Q000235:genetics / Q000378:metabolism*; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism*; D018510:RNA, Helminth / Q000235:genetics / Q000378:metabolism; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism; D016196:S Phase / Q000502:physiology*; D012568:Schizosaccharomyces / Q000201:enzymology* / Q000235:genetics; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism; D014982:Xenopus laevis
D000199:Actins; D029681:Arabidopsis Proteins; D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D009713:Nucleotidyltransferases; D011072:Poly U; D012331:RNA, Fungal; D018510:RNA, Helminth; D018749:RNA, Plant; D029702:Schizosaccharomyces pombe Proteins; D029867:Xenopus Proteins; C511096:CID-1 protein, C elegans; C520554:Cid1 protein, S pombe