Non-fatal ventricular dysrhythmias associated with severe salicylate toxicity.
BACKGROUND
Cardiac dysrhythmias, other than sinus tachycardia, rarely occur with salicylate poisoning. When dysrhythmias do occur, they are typically a terminal event.


METHODS
A 45-year-old woman presented an unknown amount of time after an intentional ingestion of aspirin and acetaminophen. On presentation her vital signs were T 39 degrees C, P 125 beats/minute, R 26 breaths/minute, and BP 153/79 mmHg. She was initially obtunded, but minutes after presentation had a generalized tonic-clonic seizure lasting approximately two minutes, which ceased after 2 mg of intravenous lorazepam. She was sedated, intubated and treated with sodium bicarbonate. Her peak salicylate concentration was 152 mg/dL. Her course was complicated by seizures and dysrhythmias, including monomorphic ventricular tachycardia and Torsades de Pointes. With bicarbonate therapy, hemodialysis, and veno-venous hemofiltration, she survived neurologically intact.


CONCLUSIONS
The etiology of these dysrhythmias is likely multifactorial. Metabolic derangements typically encountered with severe salicylism, including insensible water losses, respiratory alkalosis, and metabolic acidosis, may contribute. Iatrogenic causes, especially sodium bicarbonate therapy, may cause hypokalemia, hypocalcemia, and hypomagnesemia. Additionally, animal data suggests that high salicylate concentrations may have direct deleterious effects on the electrophysiology of cardiac cells, specifically by its action on the SA node and on the action potential of atria and Purkinje fibers.


CONCLUSIONS
Non-fatal ventricular dysrhythmias associated with salicylate toxicity are rare in patients who survive. The causes of dysrhythmias in salicylate may include electrolyte abnormalities and a direct effect of salicylate on myocardial membrane permeability.
Kent
Kristen
K
University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Ganetsky
Michael
M
Cohen
Jason
J
Bird
Steven
S
D000082:Acetaminophen / Q000506:poisoning; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D001241:Aspirin / Q000097:blood / Q000506:poisoning*; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use; D008875:Middle Aged; D013406:Suicide, Attempted; D016896:Treatment Outcome; D018754:Ventricular Dysfunction / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy
D014151:Anti-Anxiety Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D008140:Lorazepam; D001241:Aspirin