[RNA editing of serotonin 2C receptor and major mental disorders].
A-to-I RNA editing has mainly been found in various receptors and ion channels in the central nervous system, including the serotonin 2C receptor, glutamate receptor, GABA receptor, and potassium channel. Interestingly, most of them are suggested to be involved in the pathophysiology of major mental disorders such as schizophrenia, bipolar disorder, and major depression. Here we review studies examining the relationship between the serotonin 2C receptor and major mental disorders.
Iwamoto
Kazuya
K
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Japan. kaziwamoto@brain.riken.jp
Kato
Tadafumi
T
D000243:Adenosine Deaminase; D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D051379:Mice; D017393:RNA Editing; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D044405:Receptor, Serotonin, 5-HT2C; D000243:Adenosine Deaminase