title: [Effects of high selenium intake on selenium status, liver function and claw health of fattening bulls].
abstract: The effects of three dietary selenium (Se) levels (0.15, 0.35 and 0.5 mg/kg dry matter (dm) and of two Se-compounds (sodium selenite and Se-yeast) on the Se-status, liver function and claw health were studied using 36 fattening bulls in a two-factorial feeding trial that lasted 16 weeks. The claw health was assessed macroscopically and microscopically. Compared to the two control diets containing 0.15 mg Se/kg dm, the intake of the diets containing 0.35 and 0.50 mg Se/kg dm significantly (P < 0.05) increased the Se-concentration in serum, hair, liver and skeletal muscle. Compared to sodium selenite the intake of Se-yeast resulted in significantly (P < 0.05) higher Se-concentration in serum, liver and hair. Concerning the claw horn quality, there was no significant difference between the different groups; the animals receiving organic Se tended to have a better histological score (P = 0.06) at the coronary band than the groups fed with sodium selenite. The serum vitamin E level decreased significantly (P < 0.05) with increasing Se-intake, which had no influence (P > 0.1) on growth and liver function parameters. With the exception of the decrease of the serum vitamin E level indicating an oxidative stress caused by a high Se-intake, no negative effects of dietary selenium exceeding recommended levels for 4 months were observed.
authors: Veterinär-Anatomisches Institut, Universität Zürich.. mraeber@vetanat.unizh.ch
authors: M
authors: M
authors: Räber
authors: H
authors: H
authors: Geyer
authors: J
authors: J
authors: Kessler
authors: A
authors: A
authors: Gutzwiller
mesh_terms: D000818:Animals; D002417:Cattle; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D006724:Hoof and Claw / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D012643:Selenium / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D014810:Vitamin E / Q000097:blood
chemical_list: D014810:Vitamin E; D012643:Selenium