Effect of atrial natriuretic peptide on adiponectin in patients with heart failure.
BACKGROUND
The adipocyte-specific cytokine adiponectin, has cardioprotective effects, correlates with endogenous cardiac natriuretic peptides and adipocyte has guanylyl cyclase-A receptors of natriuretic peptides.


OBJECTIVE
To evaluate the effect of carperitide (atrial natriuretic peptide; ANP) on plasma adiponectin in patients with heart failure.


RESULTS
Seventy-five patients admitted to our hospital with decompensated heart failure were randomised (1:2) to nitroglycerin (group I: n = 23) or carperitide infusion (group II: n = 52). Blood samples were collected at baseline and after 7 days. Plasma levels of total and high-molecular weight (HMW) adiponectin, ANP and brain natriuretic peptide (BNP) were measured. There were no differences in baseline characteristics between the two groups. In group I, plasma levels of total and HMW adiponectin were significantly decreased (21.1+/-2.5 to 18.6+/-2.5 microg/mL, p<0.05, 12.3+/-1.8 to 10.8+/-1.7 microg/mL, p<0.05, respectively) concomitant with the decrease in plasma levels of ANP and BNP. In group II, plasma levels of total and HMW adiponectin were significantly increased (17.3+/-1.3 to 19.7+/-1.6 microg/mL, p<0.0001, 9.8+/-1.0 to 10.5+/-1.0 microg/mL, p<0.05, respectively) concomitant with the increase in ANP.


CONCLUSIONS
These findings indicate that carperitide infusion increases plasma levels of total and HMW adiponectin in patients with heart failure.
Tanaka
Toshinari
T
Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520-2192, Japan.
Tsutamoto
Takayoshi
T
Sakai
Hiroshi
H
Nishiyama
Keizo
K
Fujii
Masanori
M
Yamamoto
Takashi
T
Horie
Minoru
M
D052242:Adiponectin / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000627:therapeutic use*; D015992:Body Mass Index; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D005996:Nitroglycerin / Q000627:therapeutic use
D052242:Adiponectin; D019208:Brain-Derived Neurotrophic Factor; C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor; D005996:Nitroglycerin