Preimplantation genetic screening: "established" and ready for prime time?
Unless attempts to improve pregnancy rates and/or diminish miscarriage rates through preimplantation genetic screening (PGS) are applied to only carefully selected patients, they will fail. Because specific PGS indications have remained undefined, PGS should be considered an experimental procedure.
Gleicher
Norbert
N
Center for Human Reproduction, New York, New York 10021, USA. ngleicher@thechr.com
Weghofer
Andrea
A
Barad
David
D
D000022:Abortion, Spontaneous / Q000235:genetics / Q000517:prevention & control*; D001706:Biopsy / Q000009:adverse effects; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005820:Genetic Testing / Q000941:ethics / Q000266:history; D049674:History, 21st Century; D006801:Humans; D008297:Male; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis / Q000941:ethics / Q000266:history; D015203:Reproducibility of Results; D027724:Reproductive Techniques, Assisted / Q000941:ethics / Q000266:history; D012743:Sex Preselection; D035703:Therapies, Investigational / Q000941:ethics / Q000266:history