Serum IL-18 levels in patients with type 1 diabetes: relations to metabolic control and microvascular complications.
The study was designed to examine serum IL-18 level and its relation to metabolic control parameters and microvascular complications in type 1 diabetes mellitus (DM). Sixty two patients with type 1 DM and 30 healthy individuals were enrolled in the study. Serum IL-18 levels of patients with type 1 DM were significantly increased compared to controls (293.4+/-133.4 vs 211.2+/-63.9 pg/ml, P=0.003). Patients with poor glycemic control had higher levels of IL-18 than patients with well glycemic control (329.9+/-141.0 vs 226.3+/-89.6 pg/ml, P=0.02). There was no significant difference between the serum IL-18 levels of patients with microvascular complications and those of patients without microvascular complications (307.6+/-127.6 vs 293.2+/-145.6 pg/ml, P>0.05). IL-18 correlated positively with HbA(1c) (r=0.32, P=0.01) and postprandial blood glucose (PPBG) (r=0.26, P=0.02); and negatively with HDL-cholesterol (HDL-C) (r=-0.38, P=0.007). By linear regression analysis, PPBG was determined as the most explanatory parameter for the alterations in serum IL-18 levels (P=0.02). High levels of IL-18 in patients with type 1 DM is related to short and long term glycemic control and HDL-C levels but not to microvascular complications.
Altinova
Alev E
AE
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey. Electronic address: alevaltinova@yahoo.com.
Yetkin
Ilhan
I
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Akbay
Esen
E
Department of Endocrinology and Metabolism, Mersin University Faculty of Medicine, Mersin, Turkey.
Bukan
Neslihan
N
Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
Arslan
Metin
M
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008833:Microcirculation / Q000378:metabolism
D001786:Blood Glucose; D020382:Interleukin-18