Polymorphism of the interferon-gamma gene and risk of tuberculosis in a southeastern Chinese population.
The aim of this study is to examine the influence of the +874 A/T and +875 CA microsatellite single nucleotide polymorphisms (SNPs) of the interferon-gamma gene (IFNG) on patients with tuberculosis (TB) in the southeastern Chinese population. Genomic DNA from patients with TB (n = 301) and ethnically matched controls (n = 310) was genotyped for the two SNPs by DNA sequencing and short tandem repeat-polymerase chain reaction (PCR) method. Our results demonstrated the AA genotype of +874 A/T IFNG was associated with TB (odds ratio, 1.98; 95% confidence interval = 1.08-3.63; p = 0.035). By grouping alleles into 12 and non-12 CA repeats at the +875 CA microsatellite, the homozygous non-12/non-12 CA repeats genotype yielded the same significant trend as that observed in the +874 AA genotype. The results indicate a positive association of IFNG polymorphism with TB. Data also provide genetic evidence supporting the multiple disease hypothesis, which emphasizes that many disease genes have been involved.
Ding
Shiping
S
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang Province, China.
Li
Lanjuan
L
Zhu
Xiufang
X
D000328:Adult; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000235:genetics*
D007371:Interferon-gamma