Biomechanical, microvascular, and cellular factors promote muscle and bone regeneration.
It is becoming clear that the long-term outcome of complex bone injuries benefits from approaches that selectively target biomechanical, vascular, and cellular pathways. The typically held view of either biological or mechanical aspects of healing is oversimplified and does not correspond to clinical reality. The fundamental mechanisms of soft tissue regeneration most likely hold the key to understanding healing response.
Duda
Georg N
GN
Julius Wolff Institut, Center for Musculoskeletal Surgery and Berlin-Brandenburg Center for Regenerative Therapies Charité-Universitätsmedizin Berlin, Berlin, Germany. georg.duda@charite.de
Taylor
William R
WR
Winkler
Tobias
T
Matziolis
Georg
G
Heller
Markus O
MO
Haas
Norbert P
NP
Perka
Carsten
C
Schaser
Klaus-D
KD
D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000502:physiology*; D003097:Collateral Circulation / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005269:Femur / Q000503:physiopathology; D050723:Fractures, Bone / Q000378:metabolism; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology*; D010521:Periosteum / Q000502:physiology; D016138:Walking / Q000502:physiology; D014945:Wound Healing / Q000502:physiology