[Correlation of oral allergy syndrome due to plant-derived foods with alder pollen, rbet v 1 and rbet v 2 sensitization in Yokohama region].
OBJECTIVE
Oral allergy syndrome (OAS) to plant foods is often caused by cross-reactivity to pollen. We investigated whether there was any significant correlation between sensitization to the pollen of alder and Japanese cedar flying off in spring and prevalence of OAS in Yokohama region.


METHODS
We measured specific IgE antibodies (CAP-FEIA: CAP) against alder and Japanese cedar in 337 outpatients with skin allergy in 2005 (M:F=167:170, 33.4 years of age, on the average). In the patients who showed positive response to CAP against alder and Japanese cedar, we also tested response to CAP against rBet v 1 and rBet v 2. In addition, we statistically analyzed whether there was any correlation between prevalence of OAS and sensitization to the pollen.


RESULTS
Ratio of positive response to CAP against alder was 23.4% (79 cases) while that to CAP against Japanese cedar was 73.7% (244 cases). Response to CAP against rBet v 1 and rBet v 2 was tested in 55 cases, and the ratio of positive response to CAP against rBet v 1 was 43.6% (24 cases) while that to CAP against rBet v 2 was 27.3% (15 cases). Prevalence of OAS showed a significant positive correlation (p<0.001) with sensitization to alder, but no correlation with sensitization to Japanese cedar.


CONCLUSIONS
It was suggested that sensitization to alder pollen would be involved in prevalence of OAS in Yokohama region.
Morita
Akiko
A
Department of Dermatology, Yokohama City University.
Inomata
Naoko
N
Kirino
Mio
M
Ikezawa
Zenro
Z
D000328:Adult; D029661:Alnus / Q000276:immunology*; D028203:Cedrus; D002648:Child; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D010945:Plants, Edible / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D015995:Prevalence; D012882:Skin Tests; D013577:Syndrome
D007073:Immunoglobulin E