title: Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30 degrees C using practical approaches.
abstract: The solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures at 25 and 30 degrees C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and also was used to assess the prediction capability of the Jouyban-Acree model. A new version of the model was proposed for modeling the solubility data in water-cosolvent mixtures with the cosolvent concentration of <50% which is required in pharmaceutical formulations. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The overall MPD of the Jouyban-Acree model and the log-linear model of Yalkowsky for the entire composition range of the cosolvents were 11.0+/-8.7 and 55.4+/-17.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of <50% were 12.0+/-9.1 and 22.0+/-11.0%.
authors: Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ajouyban@hotmail.com
authors: Abolghasem
authors: A
authors: Jouyban
authors: Olduz
authors: O
authors: Azarmir
authors: Shahla
authors: S
authors: Mirzaei
authors: Davoud
authors: D
authors: Hassanzadeh
authors: Taravat
authors: T
authors: Ghafourian
authors: William Eugene
authors: WE
authors: Acree
authors: Ali
authors: A
authors: Nokhodchi
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D000465:Algorithms; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D000431:Ethanol; D005544:Forecasting; D008956:Models, Chemical; D011409:Propylene Glycols; D012995:Solubility; D012997:Solvents; D013696:Temperature; D014867:Water
chemical_list: D018712:Analgesics, Non-Narcotic; D011409:Propylene Glycols; D012997:Solvents; D014867:Water; D000082:Acetaminophen; D000431:Ethanol