[Modulating effect of Serratula coronata extract on nitric oxide metabolism in the aorta tissues of rats in lead intoxication].
Vasotoxic effect of prolonged lead exposures and the efficiency of vasoprotective effect of S. coronata extract per os addition is estimated in rats aorta It is established that lead in aorta causes a significant increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by increasing the activity of inducible isoform of NO-synthase (iNOS). The use of S. coronata extracts promotes ROS and RNS production decreasing by normalyzing the iNOS activity in exposures to lead acetate rat aortas.
Apykhtina
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Kotsiuruba
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Korkach
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D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D019659:Asteraceae / Q000737:chemistry*; D007855:Lead Poisoning / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009942:Organometallic Compounds / Q000633:toxicity; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects*
D009942:Organometallic Compounds; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II; C008261:lead acetate