title: Congenital Langerhans cell histiocytosis mimicking a "blueberry muffin baby".
abstract: Congenital Langerhans cell histiocytosis (LCH) is a rare condition with great diversity. A case of congenital skin-only LCH presenting as a "blueberry muffin baby" with a spontaneous regression by the age of 8 months is reported here. New insights into clinical manifestations and prognosis, which is not uniformly positive, are discussed. A thorough examination and a careful follow-up should be provided to these patients. Systemic therapy is warranted in multi-system disease; no consensus on treatment exists in case of LCH isolated to skin. The diagnosis of congenital self-healing LCH should be made only retrospectively.
authors: Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. ulla.sankilampi@kuh.fi
authors: Ulla
authors: U
authors: Sankilampi
authors: Sari
authors: S
authors: Huikko-Tarvainen
authors: Vesa
authors: V
authors: Kärjä
authors: Elina
authors: E
authors: Pirinen
authors: Anita
authors: A
authors: Naukkarinen
authors: Antero
authors: A
authors: Hollmén
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D010400:Penicillin G / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011379:Prognosis; D035583:Rare Diseases; D012075:Remission, Spontaneous; D012871:Skin Diseases / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D014031:Tobramycin / Q000008:administration & dosage
chemical_list: D010400:Penicillin G; D014031:Tobramycin; D000212:Acyclovir