title: Adiponectin levels associated with the development of hypertension: a prospective study.
abstract: Adiponectin is a recently discovered protein that seems to be exclusively secreted by adipocytes and is the most abundant adipose tissue-derived protein. While some recent studies have demonstrated an association between adiponectin levels and hypertension, these studies were cross-sectional in design, and the results have been inconsistent. Therefore we performed a prospective study to elucidate the role of adiponectin in the development of hypertension. The results of this study showed that serum adiponectin levels were significantly lower in hypertensive subjects than in normotensive subjects. Moreover, in logistic regression analysis, the subjects in the lowest quartile had a 3.72-fold higher risk than those in the highest quartile. Even after adjusting for potential confounding factors, this association was found to be significant. Low serum adiponectin levels were found to be independently associated with a higher risk for the development of hypertension. Our results therefore suggest that hypoadiponectinemia is a novel predictor of hypertension.
authors: Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan. imatoh@cis.fukuoka-u.ac.jp
authors: Takuya
authors: T
authors: Imatoh
authors: Motonobu
authors: M
authors: Miyazaki
authors: Yoshito
authors: Y
authors: Momose
authors: Shinichi
authors: S
authors: Tanihara
authors: Hiroshi
authors: H
authors: Une
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000328:Adult; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D052242:Adiponectin