How to identify a pharmacophore.
The inhibition of chitinases by argifin and progressively dissected analogs had been studied by a combination of kinetic and crystallographic methods (Andersen et al., 2008). This work also leads to a general understanding of structure-activity relationships for inhibitors with one distinct pharmacophor.
Prinz
Heino
H
Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, D44227 Dortmund, Germany. heino.prinz@mpi-dortmund.mpg.de
D000818:Animals; D002688:Chitinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology
D010456:Peptides, Cyclic; C413566:argifin; D014508:Urea; D002688:Chitinases