title: Update on randomized clinical trials impacting clinical care in pediatric cardiac intensive care.
abstract: Clinical trials addressing the management of infants and children with congenital heart disease are challenged by low numbers of patients with a similar diagnosis (inadequate power), variation in management strategies between institutions (difficulty developing multicentered protocols), a rapidly evolving field (equipoise), and insufficient funding. This article summarizes the challenges and the results of some single-center and multicenter trials evaluating perioperative care of infants and children undergoing surgery for congenital heart disease.
authors: Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. tabbutt@email.chop.edu
authors: Sarah
authors: S
authors: Tabbutt
authors: Chitra
authors: C
authors: Ravishankar
mesh_terms: D003422:Critical Care / Q000592:standards*; D005069:Evaluation Studies as Topic; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D015337:Multicenter Studies as Topic; D010372:Pediatrics / Q000592:standards*; D019990:Perioperative Care / Q000592:standards*; D016032:Randomized Controlled Trials as Topic / Q000639:trends*