Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "click" chemistry.
Dendrimers up to the fourth generation were successfully prepared via the divergent growth strategy using a combination of thiol-ene "click" chemistry and traditional esterification reactions. The thiol-ene reactions were conducted under solvent-free, ambient conditions at room temperature by irradiating with UV light. The fourth-generation dendrimers were subsequently functionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions.
Killops
Kato L
KL
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
Campos
Luis M
LM
Hawker
Craig J
CJ
D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010777:Photochemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D050091:Dendrimers; D013438:Sulfhydryl Compounds