title: An information-theoretic method for the treatment of plural ancestry in phylogenetics.
abstract: In the presence of recombination and gene conversion, a given genomic segment may inherit information from 2 distinct immediate ancestors. The importance of this type of molecular inheritance has become increasingly clear over the years, and the potential for erroneous inference when it is not accounted for in the statistical model is well documented. Yet, the inclusion of plural ancestry (PA) in phylogenetic analysis is still not routine. This omission is due to the greater difficulty of phylogenetic inference on general acyclic graphs compared that on with trees and the accompanying computational burden. We have developed a technique for phylogenetic inference in the presence of PA based on the principle of minimum description length, which assigns a cost--the description length--to each network topology given the observed sequence data. The description length combines the cost of poor data fit and model complexity in terms of information. This device allows us to search through network topologies to minimize the total description length. By comparing the best models obtained with and without PA, one can determine whether or not recombination has played an active role in the evolution of the genes under investigation, identify those genes that appear to be mosaic, and infer the phylogenetic network that best represents the history of the alignment. We show that the method performs well on simulated data and demonstrate its application on HIV env gene sequence data from 8 human subjects. The software implementation of the method is available upon request.
authors: Department of Biostatistics and Bioinformatics, Center for Computational Immunology, Duke University Medical Center, Durham, NC, USA.
authors: Supriya
authors: S
authors: Munshaw
authors: Thomas B
authors: TB
authors: Kepler
mesh_terms: D019295:Computational Biology / Q000379:methods*; D005785:Gene Conversion; D006801:Humans; D008954:Models, Biological; D010802:Phylogeny; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D054299:env Gene Products, Human Immunodeficiency Virus