Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus.
A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm(3)) and azalomycine (188.6 mg/dm(3)) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
Ilić
Slavica B
SB
Faculty of Technology, Bulevar Oslobodjenja 124, Leskovac, Yugoslavia. ilicslavica@yahoo.com
Konstantinović
Sandra S
SS
Veljković
Vlada B
VB
Savić
Dragisa S
DS
Lazić
Miodrag L
ML
Gojgić-Cvijović
Gordana
G
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D018533:Biomass; D002266:Carboxymethylcellulose Sodium / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D012988:Soil Microbiology; D013302:Streptomyces / Q000166:cytology* / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D002266:Carboxymethylcellulose Sodium