Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals.
OBJECTIVE
Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals.


METHODS
We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects.


RESULTS
The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load.


CONCLUSIONS
Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
Major-Pedersen
A
A
Cardiology Research Clinic Y, Bispebjerg University Hospital, 2400 Copenhagen, NV, Denmark. atmp@heart.dk
Ihlemann
N
N
Hermann
T S
TS
Christiansen
B
B
Dominguez
H
H
Kveiborg
B
B
Nielsen
D B
DB
Svendsen
O L
OL
Køber
L
L
Torp-Pedersen
C
C
D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D010919:Placebos; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin; D010919:Placebos; D005947:Glucose