Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.
Murashima
Takashi
T
Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Sakiyama
Daichi
D
Miyoshi
Daisuke
D
Kuriyama
Masanori
M
Yamada
Takashi
T
Miyazawa
Toshifumi
T
Sugimoto
Naoki
N