title: Searching for the cause of Kawasaki disease--cytoplasmic inclusion bodies provide new insight.
abstract: Kawasaki disease (KD) has emerged as the most common cause of acquired heart disease in children in the developed world. The cause of KD remains unknown, although an as-yet unidentified infectious agent might be responsible. By determining the causative agent, we can improve diagnosis, therapy and prevention of KD. Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the mysteries of KD.
authors: Department of Pediatrics, Northwestern University Feinberg School of Medicine, The Center for Kawasaki Disease, The Children's Memorial Hospital, Chicago, Illinois 60611, USA. rowley@northwestern.edu
authors: Anne H
authors: AH
authors: Rowley
authors: Susan C
authors: SC
authors: Baker
authors: Jan M
authors: JM
authors: Orenstein
authors: Stanford T
authors: ST
authors: Shulman
mesh_terms: D000328:Adult; D000941:Antigens / Q000032:analysis / Q000276:immunology; D002648:Child; D003323:Coronary Aneurysm / Q000276:immunology / Q000473:pathology; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D002479:Inclusion Bodies / Q000276:immunology*; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000276:immunology* / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology
chemical_list: D000941:Antigens; D007070:Immunoglobulin A