[Synthesis and antitumor activity of anthracene-9-carbaldehyde amino-s-triazole Schiff-bases with side-chain of S-acetic acid].
To find out a novel lead compound from heterocyclic amine Schiff bases for developing new antitumor agents, each of (4-amino-5-substituted-s-triazol-3-ylthio) -acetic acids 2a-j was condensed with anthracene-9-carbaldehyde to obtain Schiff-bases of [4-(anthracen-9-yl methylene) amino] -5-substituted-s-triazol-3-ylsulfanyl] -acetic acids 3a-j. The structures of new compounds synthesized were characterized by elemental analysis and spectral data, and in vitro antitumor activity was also evaluated against CHO, HL60 and L1210 cell lines by MTT assay.
Hu
Guo-Qiang
GQ
Institute of Pharmacy, Henan University, Kaifeng 475001, China. hgqxy@sina.com.cn
Dong
Xiu-Li
XL
Xie
Song-Qiang
SQ
Huang
Wen-Long
WL
D019342:Acetic Acid / Q000737:chemistry; D000818:Animals; D000873:Anthracenes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D018922:HL-60 Cells; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000873:Anthracenes; D000970:Antineoplastic Agents; D012545:Schiff Bases; D014230:Triazoles; C034020:anthracene; D019342:Acetic Acid