title: The effects of intracoronary nicardipine on ventricular dynamics and function in patients undergoing off-pump coronary artery bypass graft surgery.
abstract: OBJECTIVE
  To evaluate whether intracoronary nicardipine can provide myocardial protection in patients undergoing off-pump coronary artery bypass graft surgery.
  
  
  METHODS
  Clinical trial.
  
  
  METHODS
  Single-institution, academic hospital.
  
  
  METHODS
  Off-pump coronary artery bypass patients with good ejection fraction.
  
  
  METHODS
  Patients were divided into 2 equal groups: group A received 1 mL (0.1 mg) of intracoronary nicardipine before performing the distal anastomosis, and group B patients received 1 mL of NaCl in the coronary artery. Transesophageal echocardiography (PowerVision 6000, 9-mm 6-MHz probe; Toshiba, Elmsford, NY) was used in this study.
  
  
  RESULTS
  Left ventricular ejection fraction, cardiac index, tissue Doppler imaging, velocity of the left ventricle and mitral annulus, and troponin levels were measured in both groups. The incidence of diastolic dysfunction as evaluated by superior pulmonary blood flow and pulsed-wave Doppler of the mitral annulus was significantly lower in group A. Tissue Doppler imaging velocity of the left ventricle and mitral annular displacement were significantly higher in the nicardipine group. Group A patients had significantly lower incidences of ST-segment changes, prolonged pharmacologic support in the postoperative period, and lower levels of troponin after surgery.
  
  
  CONCLUSIONS
  Intracoronary nicardipine improves ventricular function in patients undergoing off-pump coronary artery bypass surgery.
authors: Department of Anesthesiology, Seton Hall University, St. Joseph's Regional Medical Center, Paterson, NJ, USA.
authors: Pierre Abdon
authors: PA
authors: Casthely
authors: Vincent
authors: V
authors: Defilippi
authors: Gregory
authors: G
authors: Pakonis
authors: Mahesh
authors: M
authors: Bikkina
authors: Thil
authors: T
authors: Yoganathan
authors: Claudia
authors: C
authors: Komer
authors: Lorraine
authors: L
authors: Cornwell
mesh_terms: D000328:Adult; D000368:Aged; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D006801:Humans; D007269:Injections, Intra-Arterial; D008875:Middle Aged; D009529:Nicardipine / Q000008:administration & dosage*; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology*
chemical_list: D009529:Nicardipine