Phytochemical investigation on leaf extract of Cordia salicifolia Cham.
The dichloromethane extract of leaves of Cordia salicifolia Cham. (Family Boraginaceae) was fractionated by SiO(2) column chromatography and analyzed by gas chromatography, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. The apolar extract is characterized by a very high content of (+)-spathulenol (0.53%). The major component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro (minimum inhibitory concentration = 200 microg/mL).
Menghini
Luigi
L
Dipartimento di Scienze del Farmaco, University G. D'Annunzio, Chieti Scalo, Italy. lmenghini@unich.it
Epifano
Francesco
F
Leporini
Lidia
L
Pagiotti
Rita
R
Tirillini
Bruno
B
D005591:Chemical Fractionation; D002849:Chromatography, Gas; D031213:Cordia / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D016480:Helicobacter pylori / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008752:Methylene Chloride; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis
D010936:Plant Extracts; D012717:Sesquiterpenes; D008752:Methylene Chloride; C013258:spathulenol