Application of carbohydrate array technology to antigen discovery and vaccine development.
Carbohydrate arrays are a new technology developed for high-throughput evaluation of interactions between carbohydrates and proteins, cells or viruses. Carbohydrate arrays contain many different carbohydrate structures on a solid support. The format allows one to probe hundreds or thousands of potential receptor-ligand interactions while using only tiny amounts of material. Recently, carbohydrate arrays have been applied to vaccine development in several ways. First, carbohydrate arrays have been utilized for the discovery and characterization of carbohydrate antigens. Second, they have been used to evaluate immune responses to vaccine candidates. Third, carbohydrate arrays have been used to identify and characterize reagents necessary for vaccine development. Although still at an early stage, carbohydrate array technology has tremendous potential for accelerating vaccine development.
Oyelaran
Oyindasola
O
National Cancer Institute, Laboratory of Medicinal Chemistry, Center for Cancer Research, NIH, 376 Boyles Street, Building 376, Room 109, Frederick, MD 21702, USA. oyelarano@ncifcrf.gov
Gildersleeve
Jeffrey C
JC
D000818:Animals; D002241:Carbohydrates / Q000138:chemical synthesis / Q000276:immunology* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000639:trends; D006801:Humans; D046228:Microarray Analysis / Q000379:methods / Q000639:trends*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*; D014612:Vaccines / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use*
D002241:Carbohydrates; D014612:Vaccines