Human ES cell profiling broadens the reach of bivalent domains.
In this issue of Cell Stem Cell, Pan et al. (2007) and Zhao et al. (2007) report genome-wide histone H3 trimethylations at lysines 4 and 27 in human embryonic stem (ES) cells. Similar gene sets arise via different experimental systems, advancing our understanding of stem cell epigenetics.
Sharov
Alexei A
AA
Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
Ko
Minoru S H
MS
D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism*; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D015894:Genome, Human / Q000235:genetics; D006657:Histones / Q000378:metabolism; D006801:Humans; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D051379:Mice; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014158:Transcription, Genetic
D006657:Histones; D008239:Lysine