Drosophila melanogaster, a model system for comparative studies on the responses to real and simulated microgravity.
A key requirement to enhance our understanding of the response of biological organisms to different levels of gravity is the availability of experimental systems that can simulate microgravity and hypergravity in ground-based laboratories. This paper compares the results obtained from analysing gene expression profiles of Drosophila in space versus those obtained in a random position machine (RPM) and by centrifugation. The correlation found validates the use of the RPM simulation technique to establish the effects of real microgravity on biological systems. This work is being extended to investigate Drosophila development in another gravity modifying instrument, the levitation magnet.
Marco
R
R
Depart. Bioquímica & Inst. Inv. Biomed. (UAM-CSIC), Madrid, Spain. roberto.marco@uam.es
Laván
D A
DA
van Loon
J J W A
JJ
Leandro
L J
LJ
Larkin
O J
OJ
Dijkstra
C
C
Anthony
P
P
Villa
A
A
Davey
M R
MR
Lowe
K C
KC
Power
J B
JB
Medina
F J
FJ
D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D002498:Centrifugation; D004331:Drosophila melanogaster / Q000235:genetics*; D004867:Equipment Design; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008280:Magnetics; D015203:Reproducibility of Results; D012399:Rotation; D013026:Space Flight; D014893:Weightlessness; D018474:Weightlessness Simulation / Q000295:instrumentation / Q000379:methods