title: [Significance of liver trauma for the incidence of sepsis, multiple organ failure and lethality of severely injured patients. An organ-specific evaluation of 24,771 patients from the trauma register of the DGU].
abstract: BACKGROUND
  The prognosis of multiple injured patients is mainly limited by initial severe hemorrhage causing hemorrhagic shock, subsequent sepsis and multiple organ failure (MOF). Although mechanisms of altered microcirculation, cytokine release etc. have been intensively investigated, little is known about the relevance of severe liver trauma as an independent predictive outcome factor in these patients. This study aimed to clarify the impact of severe liver trauma in one of the largest trauma databases.
  
  
  METHODS
  The study was based on data from the German trauma register within the German Society for Trauma Surgery (DGU) and 24,711 patients from 113 hospitals were collected for retrospective analysis between 1993 and 2005. Patients with an injury severity score (ISS) >16, no isolated head injury and primary admission to a trauma center were included. Data were allocated according to the injury pattern into I liver group (severe damage of the liver, AIS>3 and AIS abdomen <3), II Abdomen group (severe abdominal trauma AIS>3, AIS liver <3) and III Control group (liver and/or abdominal trauma AIS<3, other trauma AIS>3).
  
  
  RESULTS
  Out of 24,771 multiple injured patients from 113 trauma centers, 321 individuals were identified which matched the criteria of the liver group. Another 574 patients were allocated to the abdomen group while the majority of patients formed the trauma group (9574). Severe injury of the liver is associated with excessive demands for volume resuscitation and induces a significantly increased risk for sepsis and MOF compared to both other groups (sepsis 19.9% vs 11%; MOF 32.7% vs 16.6%). Furthermore, deleterious outcome is more frequent associated with patients with severe liver trauma (lethality 34.9%) compared to severe abdominal trauma (12%) and the control group (19.5%).
  
  
  CONCLUSIONS
  Severe liver trauma is an independent predictor for severe hemorrhage with a substantial increased risk of sepsis, MOF and trauma-related death. While conservative treatment of patients with severe liver trauma but no hemorrhage is effective, patients with hemodynamic instability seem to form a subgroup where contemporary treatment modalities are not yet sufficient.
authors: Klinik für Unfallchirurgie, Universitätsklinikum, Hufelandstrasse 55, 45122, Essen, Deutschland. sven.lendemans@gmx.de
authors: S
authors: S
authors: Lendemans
authors: M
authors: M
authors: Heuer
authors: D
authors: D
authors: Nast-Kolb
authors: C A
authors: CA
authors: Kühne
authors: M
authors: M
authors: Dammann
authors: R
authors: R
authors: Lefering
authors: S
authors: S
authors: Flohé
authors: S
authors: S
authors: Ruchholtz
authors: G
authors: G
authors: Taeger
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008099:Liver / Q000293:injuries*; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality*; D009104:Multiple Trauma / Q000401:mortality*; D009928:Organ Specificity; D012042:Registries; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D018805:Sepsis / Q000401:mortality*; D016019:Survival Analysis; D015996:Survival Rate