Mechanism unknown: prostaglandin E2 may improve HSC therapies.
A recent publication in Nature by North et al. (2007) has implicated the eicosanoid prostaglandin E2 in enhancement of hematopoietic stem cell function in zebrafish and in mice. This work may have practical therapeutic value, but much remains to be determined before this possibility is realized.
Broxmeyer
Hal E
HE
Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, R2-302, Indianapolis, IN 46202-5181, USA. hbroxmey@iupui.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D015232:Dinoprostone / Q000494:pharmacology / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D051379:Mice; D015027:Zebrafish
D015232:Dinoprostone