title: Sandwich bone augmentation using recombinant human platelet-derived growth factor and beta-tricalcium phosphate alloplast: case report.
abstract: This report presents a case of reconstructing and augmenting a buccal fenestration defect associated with simultaneous implant placement using recombinant human platelet-derived growth factor BB (rhPDGF-BB) combined with the synthetic alloplast beta-tricalcium phosphate (beta-TCP) and collagen membrane. Fenestration and fracture of the labial plate occurred at the time of implant placement at the maxillary left lateral incisor position. The sandwich bone augmentation technique was applied using autogenous bone as the inner grafting material and rhPDGF-BB + beta-TCP as the outer grafting material. A collagen barrier membrane was then tented over these materials. After approximately 5 months of healing, second-stage surgery was performed, showing complete healing at the defect site. This case suggests that the combination of rhPDGF-BB and beta-TCP can be a suitable material for predictable bone augmentation, especially during sandwich bone augmentation.
authors: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, USA.
authors: Ho-Young
authors: HY
authors: Byun
authors: Horn-Lay
authors: HL
authors: Wang
mesh_terms: D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003094:Collagen; D003751:Dental Fistula / Q000601:surgery; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007180:Incisor; D008437:Maxilla / Q000601:surgery*; D008440:Maxillary Fractures / Q000209:etiology / Q000601:surgery; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D014945:Wound Healing / Q000502:physiology
chemical_list: D043925:Angiogenesis Inducing Agents; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; C485817:beta-tricalcium phosphate; D000077214:Becaplermin; D003094:Collagen