title: Stereotactic body radiotherapy for oligometastatic lung tumors.
abstract: OBJECTIVE
  Since 1998, we have treated primary and oligometastatic lung tumors with stereotactic body radiotherapy (SBRT). The term "oligometastasis" is used to indicate a small number of metastases limited to an organ. We evaluated our clinical experience of SBRT for oligometastatic lung tumors.
  
  
  METHODS
  A total of 34 patients with oligometastatic lung tumors were included in this study. The primary involved organs were the lung (n = 15), colorectum (n = 9), head and neck (n = 5), kidney (n = 3), breast (n = 1), and bone (n = 1). Five to seven, noncoplanar, static 6-MV photon beams were used to deliver 48 Gy (n = 18) or 60 Gy (n = 16) at the isocenter, with 12 Gy/fraction within 4-18 days (median, 12 days).
  
  
  RESULTS
  The overall survival rate, local relapse-free rate, and progression-free rate at 2 years was 84.3%, 90.0%, and 34.8%, respectively. No local progression was observed in tumors irradiated with 60 Gy. SBRT-related pulmonary toxicities were observed in 4 (12%) Grade 2 cases and 1 (3%) Grade 3 case. Patients with a longer disease-free interval had a greater overall survival rate.
  
  
  CONCLUSIONS
  The clinical result of SBRT for oligometastatic lung tumors in our institute was comparable to that after surgical metastasectomy; thus, SBRT could be an effective treatment of pulmonary oligometastases.
authors: Department of Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Yoshiki
authors: Y
authors: Norihisa
authors: Yasushi
authors: Y
authors: Nagata
authors: Kenji
authors: K
authors: Takayama
authors: Yukinori
authors: Y
authors: Matsuo
authors: Takashi
authors: T
authors: Sakamoto
authors: Masato
authors: M
authors: Sakamoto
authors: Takashi
authors: T
authors: Mizowaki
authors: Shinsuke
authors: S
authors: Yano
authors: Masahiro
authors: M
authors: Hiraoka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms; D001943:Breast Neoplasms; D015179:Colorectal Neoplasms; D019583:Dose Fractionation, Radiation; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D007680:Kidney Neoplasms; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D012189:Retrospective Studies