Analysis of the Elp complex and its role in regulating exocytosis.
The regulation of membrane trafficking events in the secretory and endocytic pathways by Rab GTPases requires the cycling and activation of a Rab protein. The cycle of nucleotide binding and hydrolysis of Rab proteins is accompanied by a physical cycle of membrane translocation. An open question in membrane traffic remains how the cycle of Rab GTPase function is coupled to regulatory inputs from other cellular processes. This chapter describes the principles and methodologies used to identify the physiological regulators that influence Rab-mediated membrane traffic.
Rahl
Peter B
PB
Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.
Collins
Ruth N
RN
D000818:Animals; D000917:Antibody Formation; D002645:Chickens / Q000276:immunology; D004530:Egg Yolk / Q000276:immunology; D005089:Exocytosis / Q000502:physiology*; D051548:Histone Acetyltransferases / Q000276:immunology / Q000502:physiology*; D010445:Peptide Elongation Factors / Q000276:immunology / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000276:immunology / Q000502:physiology*; D020691:rab GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000502:physiology
D010445:Peptide Elongation Factors; D029701:Saccharomyces cerevisiae Proteins; D051548:Histone Acetyltransferases; C479559:IKI3 protein, S cerevisiae; D020691:rab GTP-Binding Proteins