Sodium chloride affects Helicobacter pylori growth and gene expression.
Epidemiological evidence links high-salt diets and Helicobacter pylori infection with increased risk of developing gastric maladies. The mechanism by which elevated sodium chloride content causes these manifestations is unclear. Here we characterize the response of H. pylori to temporal changes in sodium chloride concentration and show that growth, cell morphology, survival, and virulence factor expression are all altered by increased salt concentration.
Gancz
Hanan
H
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
Jones
Kathleen R
KR
Merrell
D Scott
DS
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology*; D013045:Species Specificity; D013997:Time Factors; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D037521:Virulence Factors; D012965:Sodium Chloride