Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum.
Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.
Ayouba
Ahidjo
A
Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75724 Paris Cedex 15, France. ahidjo.ayouba@mpl.ird.fr
Badaut
Cyril
C
Kfutwah
Anfumbom
A
Cannou
Claude
C
Juillerat
Alexandre
A
Gangnard
Stéphane
S
Behr
Charlotte
C
Mercereau-Puijalon
Odile
O
Bentley
Graham A
GA
Barré-Sinoussi
Françoise
F
Menu
Elisabeth
E
D000818:Animals; D000953:Antigens, Protozoan / Q000494:pharmacology*; D002448:Cell Adhesion; D002460:Cell Line; D005260:Female; D015658:HIV Infections / Q000382:microbiology* / Q000635:transmission; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D016778:Malaria, Falciparum / Q000276:immunology*; D010920:Placenta / Q000276:immunology / Q000469:parasitology / Q000821:virology; D010922:Placenta Diseases / Q000276:immunology / Q000469:parasitology / Q000821:virology; D010963:Plasmodium falciparum / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*; D014327:Trophoblasts / Q000469:parasitology / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
D000953:Antigens, Protozoan