title: [Pharmacotherapy with zaldiar of the pain syndrome in diabetic polyneuropathy].
abstract: Zaldiar is a complex medication containing 37,5 mg of tramadol and 325 mg of paracetamol. It has been used in the treatment of 30 patients with diabetes mellitus type II with neurological pain caused by diabetic polyneuropathy. The treatment duration was 10 days with tailored dosages from 1 to 4 tablets. The examination of patients was carried out before the treatment, during it daily and 10 days after. Pain intensity was assessed mainly by the Visual Analogue Scale (VAS). The analgesic effect of zaldiar by VAS was noticed from the 2nd day with the corresponding subjective feeling on the 4th day when the intensity of pain was reduced by 30%. In total, the pain was reduced by 50% in 23 patients and at least by 30% in the others. The drug was well-tolerated.
authors: A B
authors: AB
authors: Danilov
authors: T R
authors: TR
authors: Zharkova
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D003929:Diabetic Neuropathies / Q000150:complications* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D013577:Syndrome; D014147:Tramadol / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D004338:Drug Combinations; D000082:Acetaminophen; D014147:Tramadol