title: Cancer cachexia: measured and predicted resting energy expenditures for nutritional needs evaluation.
abstract: OBJECTIVE
  Cancer cachexia is associated with weight loss, poor nutritional status, and systemic inflammation. Accurate nutritional support for patients is calculated on resting energy expenditure (REE) measurement or prediction. The present study evaluated the agreement between measured and predicted REE (mREE and pREE, respectively) and the influence of acute phase response (APR) on REE.
  
  
  METHODS
  Thirty-six patients with cancer were divided into weight-stable (WS; weight loss <2%) and weight-losing (WL; weight loss >5%) patients. Measured REE was measured by indirect calorimetry and adjusted for fat-free mass (FFM). The Bland-Altman approach was used to assess the agreement between mREE and pREE from the Harris-Benedict equations (HBE). Blood levels of C-reactive protein were assessed.
  
  
  RESULTS
  There was no difference in mREE between groups (WS 1677 +/- 273, WL 1521 +/- 305) even when mREE was adjusted for FFM (WS 1609 +/- 53, WL 1589 +/- 53). In WL patients, FFM-adjusted REE correlated with blood C-reactive protein levels (r = 0.471, P = 0.048). HBEs tend to underestimate REE in both groups.
  
  
  CONCLUSIONS
  WL and WS patients with cancer had similar REEs but were different in terms of APR. APR could contribute to weight loss through enhancing REE. In a clinical context, HBE was in poor agreement with mREE in both groups.
authors: Institut National de la Santé et de la Recherche Médicale, Unité 694, Université d'Angers; Laboratoire de biochimie et biologie moléculaire, Centre Hospitalier Universitaire, Angers, France.
authors: Gyasi
authors: G
authors: Johnson
authors: Agnès
authors: A
authors: Sallé
authors: Gérard
authors: G
authors: Lorimier
authors: Laurent
authors: L
authors: Laccourreye
authors: Bernard
authors: B
authors: Enon
authors: Vincent
authors: V
authors: Blin
authors: Yann
authors: Y
authors: Jousset
authors: Jean-Pierre
authors: JP
authors: Arnaud
authors: Yves
authors: Y
authors: Malthièry
authors: Gilles
authors: G
authors: Simard
authors: Patrick
authors: P
authors: Ritz
mesh_terms: D000210:Acute-Phase Reaction / Q000378:metabolism*; D001481:Basal Metabolism / Q000502:physiology*; D001823:Body Composition / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism; D002100:Cachexia / Q000378:metabolism*; D002153:Calorimetry, Indirect; D003110:Colonic Neoplasms / Q000378:metabolism; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009751:Nutritional Requirements; D011237:Predictive Value of Tests; D015431:Weight Loss
chemical_list: D002097:C-Reactive Protein