title: Cooperative Brønsted acid-type organocatalysis: alcoholysis of styrene oxides.
abstract: We present a mild and efficient method for the completely regioselective alcoholysis of styrene oxides utilizing a cooperative Brønsted acid-type organocatalytic system comprised of mandelic acid (1 mol %) and N,N'-bis-[3,5-bis-(trifluoromethyl)phenyl]-thiourea (1 mol %). Various styrene oxides are readily transformed into their corresponding beta-alkoxy alcohols in good to excellent yields at full conversion. Simple aliphatic and sterically demanding, as well as unsaturated and acid-sensitive alcohols can be employed.
authors: Institut für Organische Chemie, Justus-Liebig-Universität, Heinrich-Buff-Ring 58, Giessen, Germany.
authors: Torsten
authors: T
authors: Weil
authors: Mike
authors: M
authors: Kotke
authors: Christian M
authors: CM
authors: Kleiner
authors: Peter R
authors: PR
authors: Schreiner