Insight into the role of inositol phosphoglycans in insulin response and the regulation of glucose and lipid metabolism illustrated by the response of adipocytes from two strains of rats.
Differences in biochemical and hormone profiles between two strains of rats provide insights into the relationships between insulin response, inositol phosphoglycans and lipid metabolism in adipose tissue. The results suggest the apparent anomaly of a higher rate of lipogenesis and response to insulin with a lower fat pad weight in the Charles River vs. Harlan Olac group relates to: (i) enzyme pre-programming with IPG-A, (ii) faster turnover of lipid, (iii) effects of leptin and cAMP.
Kunjara
S
S
University College London Medical School, Department of Immunology and Molecular Pathology, Molecular Medicine Unit, London W1T 4JF, UK.
McLean
P
P
Greenbaum
A L
AL
Rademacher
T W
TW
D017667:Adipocytes; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007295:Inositol Phosphates / Q000737:chemistry / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism; D050356:Lipid Metabolism; D050155:Lipogenesis; D008099:Liver / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D007295:Inositol Phosphates; D007328:Insulin; D020738:Leptin; D011134:Polysaccharides; C028039:inositol phosphate glycan; D000242:Cyclic AMP; D005947:Glucose