[Hormonal desintegration in metabolic syndrome].
The aim of the study is to reveal hormonal disintegration in patients with metabolic syndrome (MS). The examination of 27 healthy persons and 38 patients with metabolic syndrome was performed with assistance of Clamp-test and computer tomography. The dynamics of insulin, leptin, cortisol, testosterone and estradiol levels was studied. Influence of hyperinsulinemia and insulin resistance, leptin and cortisol levels fluctuation on MS development is shown. Probable mechanisms of hormonal interaction being in the base of the pathological process are proposed. Influence of sensitivity to insulin on the activity of sympathetic nervous system and increase of arterial pressure is demonstrated.
Sokolov
E I
EI
Mironova
E K
EK
Zykova
A A
AA
D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000378:metabolism; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004958:Estradiol / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D008875:Middle Aged; D011859:Radiography; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood*
D015415:Biomarkers; D007328:Insulin; D020738:Leptin; D013739:Testosterone; D004958:Estradiol; D006854:Hydrocortisone