Measuring noncalcified coronary atherosclerotic plaque using voxel analysis with MDCT angiography: phantom validation.
OBJECTIVE
This purpose of this study was to evaluate the accuracy and reproducibility of a voxel analysis technique for measuring noncalcified plaque in the coronary arteries.


METHODS
Polyethylene phantoms representing noncalcified plaque were scanned in both MDCT and micro-CT scanners and inter- and intrareader variability of volume calculation was performed.


RESULTS
Volume measurements by both MDCT and micro-CT were comparable to the true volume as measured by micrometry (< 3%, p = 0.05).


CONCLUSIONS
There appears to be no significant difference (< 3%) between MDCT and micro-CT measurements.
Sabir
Adeel
A
Department of Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School, One Deaconess Rd., WCC-302, Boston, MA 02215, USA.
Yam
Chun-Shan
CS
Yoshimura
Norihiko
N
Buros
Jacqueline L
JL
De Grand
Alec M
AM
Raptopoulos
Vassilios
V
Clouse
Melvin E
ME
D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional; D019047:Phantoms, Imaging; D011095:Polyethylenes; D011857:Radiographic Image Interpretation, Computer-Assisted; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed
D011095:Polyethylenes