title: Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK.
abstract: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK.
  
  
  RESULTS
  Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly.
  
  
  CONCLUSIONS
  Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.
authors: Department of Medical and Cardiovascular Studies, Western Infirmary, Glasgow, UK. gcl136@clinmed.gla.ac.uk
authors: I
authors: I
authors: Bone
authors: L
authors: L
authors: Belton
authors: A S
authors: AS
authors: Walker
authors: J
authors: J
authors: Darbyshire
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007276:Injections, Intraventricular / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000379:methods; D019370:Observation; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage*; D017096:Prion Diseases / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: D000925:Anticoagulants; D010426:Pentosan Sulfuric Polyester