title: Deep infection in total hip arthroplasty.
abstract: OBJECTIVE
  To report on a 30-year prospective study of deep infection in 1993 consecutive total hip arthroplasties performed by a single surgeon.
  
  
  METHODS
  The relations of numerous variables to the incidence of deep infection were studied.
  
  
  RESULTS
  The cumulative infection rate after the index total hip arthroplasties rose from 0.8% at 2 years to 1.4% at 20 years; 9.6% of the index operations required further surgery. When infections attributed to these secondary procedures were included, the infection rate rose from 0.9% at 2 years to 2% at 20 years. Although the usual variables increased the incidence of infection, the significant and most precise predictors of infection were radiologic diagnoses of upper pole grade III and protrusio acetabuli, an elevated erythrocyte sedimentation rate, alcoholism and units of blood transfused.
  
  
  CONCLUSIONS
  From 2-20 years, the incidence of deep infection doubled. Preoperative recognition of the first 4 risk factors permits the use of additional prophylactic measures. Spinal or epidural anesthesia reduced the units of blood transfused (the fifth risk factor) and, hence, the risk of infection. Although most deep infections are seeded while the wound is open, there are many possible postoperative causes. In this study, fewer than one-third of the infections that presented after 2 years were related to hematogenous spread. The efficacy of clean air technology was supported, and it is recommended that all measures that may reduce the incidence of deep infection be employed.
authors: Port Arthur Health Centre, Lakehead University, Thunder Bay, Ontario, Canada. drhenryhamilton@hotmail.com
authors: Henry
authors: H
authors: Hamilton
authors: John
authors: J
authors: Jamieson
mesh_terms: D019072:Antibiotic Prophylaxis; D019644:Arthroplasty, Replacement, Hip / Q000706:statistics & numerical data*; D001207:Asepsis; D001424:Bacterial Infections / Q000453:epidemiology* / Q000517:prevention & control; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006764:Hospitals, Community / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D009864:Ontario; D011446:Prospective Studies; D012086:Reoperation; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000517:prevention & control; D013212:Staphylococcus epidermidis; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control