title: Transsphincteric pH profile at the gastroesophageal junction.
abstract: OBJECTIVE
  Esophageal acid exposure conventionally is measured 5 cm above the lower esophageal sphincter (LES). The aim of this study was to compare pH profiles at sites within the LES, the distal esophagus, and the proximal stomach.
  
  
  METHODS
  Ten normal subjects underwent esophageal manometry followed by 24-hour esophagogastric pH monitoring using an 8-channel pH probe recording at 5 and 1.5 cm above and at 0, 1.5, 3.0, 4.5, 6.0, and 9.5 cm below the proximal LES border. During pH recording, a 4-hour gastric emptying test with an egg sandwich meal was performed.
  
  
  RESULTS
  The LES was 3.2 +/- 0.4 cm in length. There was a progressive increase in acid exposure from the esophageal to the gastric pH sensors. pH was less than 4 for 3.4% +/- 1.6%, 12.7% +/- 8.5%, 26.5% +/- 10.2%, 48.1% +/- 11.3%, 66.5% +/- 9.9%, 80.8% +/- 5.6%, 89.2% +/- 3.0%, and 96.7% +/- 1.1% of the total time for pH probes at 5 and 1.5 cm above and 0, 1.5, 3, 4.5, 6.0, and 9.5 cm below the proximal LES border, respectively. Percentage acid exposures correlated significantly with the position of the probe (r = -0.95; P < .01). Intrasphincteric acidity increased postprandially. Gastric emptying was correlated inversely with the intragastric hydrogen ion concentration (r = -0.82).
  
  
  CONCLUSIONS
  The percentage of recording time that pH was less than 4 was significantly higher in the intrasphincteric area and 1.5 cm above the proximal LES compared with the traditional site 5 cm above the proximal manometric LES border. High acid exposure in the intrasphincteric region might explain the susceptibility of the distal esophagus to erosions, strictures, and Barrett's esophagus.
authors: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
authors: Jyothi
authors: J
authors: Mekapati
authors: Linda C
authors: LC
authors: Knight
authors: Alan H
authors: AH
authors: Maurer
authors: Robert S
authors: RS
authors: Fisher
authors: Henry P
authors: HP
authors: Parkman
mesh_terms: D000328:Adult; D050782:Esophageal pH Monitoring; D004943:Esophagogastric Junction / Q000737:chemistry* / Q000502:physiology*; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D013997:Time Factors