Characteristics of Vogt-Koyanagi-Harada disease in a French cohort: ethnicity, systemic manifestations, and HLA genotype data.
OBJECTIVE
To assess in patients followed in a French referral center the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease and the HLA-DRB1*04 genotype.


METHODS
Patients previously diagnosed as having VKH disease were re-evaluated in a cross-sectional study using the VKH Committee's revised criteria. High-resolution HLA-DRB1 genotyping was performed.


RESULTS
Eleven white patients satisfied ophthalmologic diagnostic criteria. All originated from Mediterranean countries. Nine and 3 patients had neurologic and/or cutaneous abnormalities, respectively. Among DRB1*04-positive patients, the HLA-DRB1*0405 subtype was 71%.


CONCLUSIONS
These VKH patients predominantly had an incomplete form. The HLA-DRB1*0405 subtype allele was enriched in a group of Mediterranean stock.
Abad
S
S
Service de Médecine Interne, Laboratoire de recherche clinique et thérapeutique UPRES EA3409, Université Paris XIII, Faculté Léonard de Vinci, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Paris, France. sebastien.abad@avc.ap-hop-paris.fr
Monnet
D
D
Caillat-Zucman
S
S
Mrejen
S
S
Blanche
P
P
Chalumeau
M
M
Mouthon
L
L
Dhote
R
R
Brézin
A P
AP
D000328:Adult; D000483:Alleles; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005060:Europe / Q000208:ethnology; D005260:Female; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D019083:Mediterranean Region; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D012189:Retrospective Studies; D012871:Skin Diseases / Q000209:etiology; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000208:ethnology / Q000235:genetics / Q000503:physiopathology*; D044465:White People
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C527195:HLA-DRB1*04 antigen