Sic transit gloria: farewell to the epidermal transit amplifying cell?
For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.
Jones
Philip H
PH
MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK. phj20@hutchison-mrc.cam.ac.uk
Simons
Benjamin D
BD
Watt
Fiona M
FM
D000818:Animals; D002453:Cell Cycle; D019070:Cell Lineage; D049109:Cell Proliferation; D000078404:Epidermal Cells; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology