title: Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis.
abstract: Coxsackieviruses cause substantial human morbidity and mortality, but the underlying molecular mechanisms of disease remain obscure. Here, we review the effects that the cell status--both cellular activation, and the cell cycle--may have on the outcome of virus infection. We propose that these viruses have evolved to undergo productive infection in cells at the G1/S stage of the cell cycle, and to preferentially establish persistence/latent infection in quiescent cells, and we provide possible explanations for these outcomes. Finally, we consider the implications of these interactions for virus transmission and host pathology.
authors: Department of Biology, San Diego State University, CA 92182-4614, USA.
authors: R
authors: R
authors: Feuer
authors: J L
authors: JL
authors: Whitton
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D003384:Coxsackievirus Infections / Q000821:virology*; D004770:Enterovirus / Q000235:genetics / Q000502:physiology*; D015967:Gene Expression Regulation, Viral; D006801:Humans; D014779:Virus Replication