title: Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53.
abstract: We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
authors: Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93-509, Poland.
authors: M
authors: M
authors: Szybka
authors: I
authors: I
authors: Zawlik
authors: D
authors: D
authors: Kulczycka
authors: E
authors: E
authors: Golanska
authors: E
authors: E
authors: Jesien
authors: D
authors: D
authors: Kupnicka
authors: R
authors: R
authors: Stawski
authors: S
authors: S
authors: Piaskowski
authors: E
authors: E
authors: Bieniek
authors: M
authors: M
authors: Zakrzewska
authors: R
authors: R
authors: Kordek
authors: P P
authors: PP
authors: Liberski
authors: P
authors: P
authors: Rieske
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics*; D005260:Female; D016158:Genes, p53; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53