[Antibodies against Trypanosoma cruzi in intact mice and their oncoprotective effect].
Trypanosoma cruzi antibodies that are important in the anticancer effect of this species of Trypanosoma were first detected in 14% of the 374 examined intact mice. These background antibodies were polyclonal, i.e. they reacted with one or other of 9 genetically different T. cruzi clones and detected antigenic determinants in different structures of a Trypanosoma cell. Their spread in the population varied with animal batches; the titers were not greater than 1:40 and the level remained steady during a one-month observation. The growth of Ehrlich's adenomacarcinoma inoculated to these mice was inhibited by 1.5-2.5 times and, in some cases, terminated in total regression. The paper discusses the capacities of such antibodies in man and their inductor-commonness of the antigens of the normal intestinal microflora and the cells of the vertebrate with T. cruzi.
Kallinikova
V D
VD
Batmonkh
Ts
Ts
Kosobokova
E N
EN
Pakhorukova
L V
LV
Ogloblina
T A
TA
Kravtsov
E G
EG
Karpenko
L P
LP
Matekin
P V
PV
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology; D000970:Antineoplastic Agents / Q000097:blood* / Q000276:immunology; D002286:Carcinoma, Ehrlich Tumor / Q000175:diagnosis / Q000276:immunology*; D018450:Disease Progression; D051379:Mice; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000970:Antineoplastic Agents