[Results of the ocular hypertension treatment study and the confocal scanning laser ophthalmoscopy ancillary study and evaluation of the heidelberg retina tomograph].
The Ocular Hypertension Treatment Study (OHTS) has shown that analyzing changes of the optic disc configuration is superior to evaluating visual field findings for the early detection of primary open angle glaucoma. The Confocal Scanning Laser Ophthalmoscopy Ancillary Study (CSLO) is the first study to reveal that certain topographic baseline measurements of the optic disc are significantly associated with the development of primary open angle glaucoma in patients with ocular hypertension. An abnormally increased "mean height contour" value proved to be the individual parameter connected with the highest risk. The reliability of the Moorfields Regression Analysis of certain individual sectors during early detection of a primary angle glaucoma is higher than that of the global measurement. The temporal superior and inferior as well as the nasal inferior sectors have the highest positive predictive values and the largest risks in both univariate and multivariate analysis.
Klatt
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Universitätsaugenklinik, Bonn, Deutschland.
Schmidt
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E
Scheuerle
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AF
D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D018613:Microscopy, Confocal / Q000379:methods*; D009798:Ocular Hypertension / Q000150:complications / Q000175:diagnosis*; D009887:Ophthalmoscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity