title: Sic transit gloria: farewell to the epidermal transit amplifying cell?
abstract: For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.
authors: MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK. phj20@hutchison-mrc.cam.ac.uk
authors: Philip H
authors: PH
authors: Jones
authors: Benjamin D
authors: BD
authors: Simons
authors: Fiona M
authors: FM
authors: Watt
mesh_terms: D000818:Animals; D002453:Cell Cycle; D019070:Cell Lineage; D049109:Cell Proliferation; D000078404:Epidermal Cells; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology