The age incidence of childhood B-cell precursor acute lymphoblastic leukemia in Mexico City.
The objective of this population-based survey was to assess the peak age of incidence of B-cell precursor acute lymphoblastic leukemia (ALL) in children in Mexico City (MC). All patients were classified according to their immunophenotype, and only B-cell precursor and T-lineage were analyzed. Rates of incidence were calculated x10 children. Of the 364 children from MC who were included in this study, immunophenotyping had been performed for 81.6%. The frequency of B-cell precursor ALL was 76.1%, whereas T lineage ALL showed a frequency of 23.6%. Peak age for ALL was 2 to 3 years of age. B-cell precursor ALL was the major contributor to peak age; T lineage ALL showed a peak among 1 and 3 years of age. We conclude that the age peak for children with ALL in MC is within the ranges reported for developed countries and that B-cell precursor ALL is the main contributor to these peak.
Bernaldez-Rios
Roberto
R
Hematology, Pediatric Hospital, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Ortega-Alvarez
Manuel C
MC
Perez-Saldivar
Maria L
ML
Alatoma-Medina
Norma E
NE
Del Campo-Martinez
Maria de Los A
Mde L
Rodriguez-Zepeda
Maria Del Carmen
Mdel C
Montero-Ponce
Ines
I
Franco-Ornelas
Sergio
S
Fernandez-Castillo
Gabriela
G
Nuñez-Villegas
Nora N
NN
Taboada-Flores
Miguel A
MA
Flores-Lujano
Janet
J
Argüelles-Sanchez
Muriel E
ME
Juarez-Ocaña
Servando
S
Fajardo-Gutierrez
Arturo
A
Mejia-Arangure
Juan Manuel
JM
D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011153:Population; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000453:epidemiology*; D016019:Survival Analysis