Selection of patients for natural cycle in vitro fertilization combined with in vitro maturation of immature oocytes.
OBJECTIVE
To determine a successful method of selecting patients for natural cycle IVF combined with in vitro maturation (IVM) of immature oocytes and to determine treatment efficacy.


METHODS
Retrospective analysis of IVF treatments.


METHODS
Hospital IVF clinic.


METHODS
Women with infertility according to ovarian reserve and endocrine profile were selected for different treatments.


METHODS
According to screening criteria, infertile women were divided into three treatments: [1] natural cycle IVF combined with IVM (IVF/M), [2] IVM alone, and [3] controlled ovarian hyperstimulation (COH) with gonadotropin.


METHODS
The distribution of completed IVF-ET cycles in each treatment; clinical pregnancy and implantation rates in each treatment.


RESULTS
A total of 417 cycles were started, and 410 cycles (98.3%) were completed. Of 410 cycles, 151 (36.8%) were treated by natural cycle IVF/M, 63 (15.4%) underwent IVM alone, and 196 (47.8%) underwent COH. With increasing age fewer cycles can be treated by natural cycle IVF/M or IVM. Clinical pregnancy rates were 40.4% (61 of 151) for natural cycle IVF/M, 41.3% (26 of 63) for IVM alone, and 37.8% (74 of 196) for COH. There were no differences in implantation rate in the three groups (17.8% [82 of 462], 16.7% [35 of 210], and 20.1% [103 of 513]).


CONCLUSIONS
Natural cycle IVF/M together with IVM-alone treatment can offer more than 50% of infertile women with an acceptable pregnancy and implantations rates.
Lim
Jin-Ho
JH
Maria Fertility Hospital, Seoul, South Korea.
Yang
Seong-Ho
SH
Xu
Ye
Y
Yoon
San-Hyun
SH
Chian
Ri-Cheng
RC
D000328:Adult; D000465:Algorithms; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology*; D018579:Patient Selection; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome