title: Acylated triterpenoid saponins from Schima noronhae and their cell growth inhibitory activity.
abstract: Two new acylated triterpenoid saponins were isolated from the branches of Schima noronhae by bioassay-guided purification. Their chemical structures were established on the basis of spectroscopic analysis and chemical means as 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucuronopyranosyl 22-O-angeloyl-A1-barrigenol (1) and 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucuronopyranosyl 22-O-angeloylerythrodiol (2). Compounds 1 and 2 showed cell growth inhibitory activity against both HeLa and DLD1 cells at a concentration of less than 10 microM.
authors: Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
authors: Takashi
authors: T
authors: Ohtsuki
authors: Takashi
authors: T
authors: Miyagawa
authors: Takashi
authors: T
authors: Koyano
authors: Thaworn
authors: T
authors: Kowithayakorn
authors: Nobuo
authors: N
authors: Kawahara
authors: Yukihiro
authors: Y
authors: Goda
authors: Masami
authors: M
authors: Ishibashi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013785:Thailand; D028242:Theaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C530245:3-O-alpha-L-rhamnopyranosyl-(1-4)-beta-D-galactopyranosyl-(1-3)-(beta-D-glucopyranosyl-(1-2))-beta-D-glucuronopyranosyl 22-O-angeloyl-A1-barrigenol; C530246:3-O-alpha-rhamnopyranosyl-(1-4)-beta-D-galactopyranosyl-(1-3)-(beta-D-glucopyranosyl-(1-2))-beta-D-glucuronopyranosyl 22-O-angeloylerythrodiol; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes