Body mass index and its association with genitourinary disorders in men undergoing prostate cancer screening.
BACKGROUND
Elevated body mass index (BMI) may predispose to several pelvic pathologies.


OBJECTIVE
We tested the association between BMI and five end points, namely, (i) erectile dysfunction (ED); (ii) lower urinary tract symptoms (LUTS); (iii) chronic prostatitis-associated pain (CPP); and ejaculatory dysfunction that is subdivided between (iv) pain/discomfort on ejaculation; and (v) subjectively decreased ejaculate volume.


METHODS
Age, height, and weight were prospectively recorded in a cohort of 590 consecutive healthy men undergoing prostate cancer screening. Continuously coded and categorized BMI (World Health Organization classification) were studied.


METHODS
Age-adjusted analyses relied on logistic and linear regression models, according to data type.


RESULTS
The average age was 54.1 years (range 30-83). Of all, 296 were overweight (50.2%, BMI 25-29.9 kg/m(2)) and 85 were obese (14.4%, BMI > or = 30 kg/m(2)). After age adjustment, elevated continuously coded BMI (P < 0.001) and elevated categorized BMI (P = 0.01) were associated with worse erectile function. Conversely, after age adjustment, elevated continuously coded BMI (P = 0.02) and elevated categorized BMI (P = 0.05) were associated with a lower rate of subjectively decreased ejaculate volume. Finally, after age adjustment, elevated categorically coded BMI was related to lower rates of CPP (P < 0.001) and to a lower rate of pain/discomfort on ejaculation (P = 0.03).


CONCLUSIONS
In men undergoing prostate cancer screening, the effect of BMI on the five end points is not invariably detrimental. Elevated BMI may predispose to ED, but may also decrease the rate of pain/discomfort on ejaculation and may lower the reported rate of subjectively decreased ejaculate volume. Finally, it appeared to have no effect on LUTS.
Bhojani
Naeem
N
Cancer Prognostics and Health Outcomes unit, University of Montreal Health Center, Montreal, Quebec, Canada.
Perrotte
Paul
P
Hutterer
Georg
G
Suardi
Nazareno
N
Jeldres
Claudio
C
Shariat
Shahrokh F
SF
Capitanio
Umberto
U
Arjane
Philippe
P
Widmer
Hugues
H
Benard
Francois
F
Peloquin
Francois
F
Montorsi
Francesco
F
Karakiewicz
Pierre
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000175:diagnosis* / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D011792:Quebec