Comparison of salivary cytokine levels in oral cancer patients and healthy subjects.
In order to find informative salivary biomarkers specific to oral cancer we examined expression of 4 kinds of cytokine in saliva. Levels of interleukins (IL-1beta, -6, -8) and osteopontin were measured by ELISA using whole saliva samples collected from 19 patients with oral cancer (9 men, 10 women; mean age, 60.9 years) and 20 healthy persons (15 men, 5 women; mean age, 32 years). Expression of the 4 cytokines was higher in patients with oral cancer than in healthy controls. The difference was significant in IL-6, in particular. The results suggest that saliva offers a potential target for a screening test aimed at detection of precancerous lesions.
Katakura
Akira
A
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan.
Kamiyama
Isao
I
Takano
Nobuo
N
Shibahara
Takahiko
T
Muramatsu
Takashi
T
Ishihara
Kazuyuki
K
Takagi
Ryo
R
Shouno
Takehiro
T
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D016207:Cytokines / Q000032:analysis*; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D053495:Osteopontin / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*
D014408:Biomarkers, Tumor; D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D012471:Salivary Proteins and Peptides; D053495:Osteopontin