title: Digital breast tomosynthesis: a pilot observer study.
abstract: OBJECTIVE
  The objective of our study was to assess ergonomic and diagnostic performance-related issues associated with the interpretation of digital breast tomosynthesis-generated examinations.
  
  
  METHODS
  Thirty selected cases were read under three different display conditions by nine experienced radiologists in a fully crossed, mode-balanced observer performance study. The reading modes included full-field digital mammography (FFDM) alone, the 11 low-dose projections acquired for the reconstruction of tomosynthesis images, and the reconstructed digital breast tomosynthesis examination. Observers rated cases under the free-response receiver operating characteristic, as well as a screening paradigm, and provided subjective assessments of the relative diagnostic value of the two digital breast tomosynthesis-based image sets as compared with FFDM. The time to review and diagnose each case was also evaluated.
  
  
  RESULTS
  Observer performance measures were not statistically significant (p > 0.05) primarily because of the small sample size in this pilot study, suggesting that showing significant improvements in diagnosis, if any, will require a larger study. Several radiologists did perceive the digital breast tomosynthesis image set and the projection series to be better than FFDM (p < 0.05) for diagnosing this specific case set. The time to review, interpret, and rate the examinations was significantly different for the techniques in question (p < 0.05).
  
  
  CONCLUSIONS
  Tomosynthesis-based breast imaging may have great potential, but much work is needed before its optimal role in the clinical environment is known.
authors: Department of Radiology, Imaging Research, University of Pittsburgh, F.A.R.P. Bldg., 3362 Fifth Ave., Pittsburgh, PA 15213, USA.
authors: Walter F
authors: WF
authors: Good
authors: Gordon S
authors: GS
authors: Abrams
authors: Victor J
authors: VJ
authors: Catullo
authors: Denise M
authors: DM
authors: Chough
authors: Marie A
authors: MA
authors: Ganott
authors: Christiane M
authors: CM
authors: Hakim
authors: David
authors: D
authors: Gur
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002983:Clinical Competence; D006804:Ergonomics; D006801:Humans; D008327:Mammography / Q000379:methods*; D015588:Observer Variation; D010865:Pilot Projects; D011856:Radiographic Image Enhancement; D011857:Radiographic Image Interpretation, Computer-Assisted