Nuclear apoptosis contributes to sarcopenia.
Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.
Alway
Stephen E
SE
Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506-9227, USA. salway@hsc.wvu.edu
Siu
Parco M
PM
D000375:Aging / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D045304:Cytochromes c / Q000032:analysis; D015444:Exercise / Q000502:physiology; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000737:chemistry; D009133:Muscular Atrophy / Q000503:physiopathology*; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology*
D045304:Cytochromes c