[Immune system reactivity in patients with chronic hepatitis c].
OBJECTIVE
To determine levels of IL-1beta, IL-2, IL-4, IL-6, TNF-alpha, IFN-alpha, IFN-gamma in patients with chronic hepatitis C (CHC).


METHODS
Peripheral blood cytokines were measured with enzyme immunoassay (Protein contour kits, St-Petersburg).


RESULTS
Higher content of IL-2, IFNa, IFNg was found in older patients with negative results of examination for HCV RNA, a/HCVcore IgM, a/HCV/ns3,5, genotype 3a, evidencing for higher reactivity of the immune system. High levels of IL-1beta, IL-6, TNFa were detected in young patients with narcotic drug consumption history, with high enxymatic activity, biliary inflammation, genotype 1b, high index of histological activity.


CONCLUSIONS
The above changes characterize the severity of morphological, necrotic-inflammatory changes in the liver.
Sobchak
D M
DM
Korochkina
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OV
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D016207:Cytokines / Q000097:blood*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology* / Q000821:virology; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000097:blood*; D008099:Liver / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index
D016207:Cytokines; D004279:DNA, Viral; D007371:Interferon-gamma