Acute renal failure during ATRA treatment.
All-trans-retinoic acid (ATRA), which is used in acute promyelocytic leukemia, is usually well tolerated, but some side effects can be observed. Retinoic acid syndrome is the most severe side effect. Triazole derivatives such as fluconazole inhibit the NADPH-dependent cytochrome P-450-mediated catabolism of ATRA and are increased plasma levels of ATRA. Here, the authors report a case of APL who developed acute renal failure during ATRA and concurrent use of fluconazole.
Yarali
Nese
N
Dr. Sami Ulus Children's Hospital, Ankara, Turkey. neseyarali@yahoo.com
Tavil
Betül
B
Kara
Abdurrahman
A
Ozkasap
Serdar
S
Tunç
Bahattin
B
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy; D000293:Adolescent; D000935:Antifungal Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D014212:Tretinoin; D015725:Fluconazole