title: Design and synthesis of new 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles as anticonvulsant agents.
abstract: A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism.
authors: Department of Medicinal Chemistry, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. azarghi@yahoo.com
authors: Afshin
authors: A
authors: Zarghi
authors: Zahra
authors: Z
authors: Hajimahdi
authors: Shohreh
authors: S
authors: Mohebbi
authors: Hootesa
authors: H
authors: Rashidi
authors: Sasan
authors: S
authors: Mozaffari
authors: Sahar
authors: S
authors: Sarraf
authors: Mehrdad
authors: M
authors: Faizi
authors: Seyed Abbas
authors: SA
authors: Tabatabaee
authors: Abbas
authors: A
authors: Shafiee
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004597:Electroshock; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D010433:Pentylenetetrazole; D011963:Receptors, GABA-A / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D007202:Indicators and Reagents; D010069:Oxadiazoles; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole