title: The prevalence of plant food allergies: a systematic review.
abstract: BACKGROUND
  There is uncertainty regarding the prevalence of allergies to plant food.
  
  
  OBJECTIVE
  To assess the prevalence of allergies to plant food according to the different subjective and objective assessment methods.
  
  
  METHODS
  Our systematic search of population-based studies (since 1990) in the literature database MEDLINE focused on fruits, vegetables/legumes, tree nuts, wheat, soy, cereals, and seeds. Prevalence estimates were categorized by food item and method used (food challenges, skin prick test, serum IgE, parent/self-reported symptoms), complemented by appropriate meta-analyses.
  
  
  RESULTS
  We included 36 studies with data from a total of over 250,000 children and adults. Only 6 studies included food challenge tests with prevalences ranging from 0.1% to 4.3% each for fruits and tree nuts, 0.1% to 1.4% for vegetables, and < 1% each for wheat, soy, and sesame. The prevalence of sensitization against any specific plant food item assessed by skin prick test was usually < 1%, whereas sensitization assessed by IgE against wheat ranged as high as 3.6% and against soy as high as 2.9%. For fruit and vegetables, prevalences based on perception were generally higher than those based on sensitization, but for wheat and soy in adults, sensitization was higher. Meta-analyses showed significant heterogeneity between studies regardless of food item or age group.
  
  
  CONCLUSIONS
  Population-based prevalence estimates for allergies to plant products determined by the diagnostic gold standard are scarce. There was considerable heterogeneity in the prevalence estimates of sensitization or perceived allergic reactions to plant food.
authors: Academic Medical Center, Department of Experimental Immunology, Laboratory of Allergy, Amsterdam, The Netherlands. l.zuidmeer@amc.uva.nl
authors: Laurian
authors: L
authors: Zuidmeer
authors: Klaus
authors: K
authors: Goldhahn
authors: Roberto J
authors: RJ
authors: Rona
authors: David
authors: D
authors: Gislason
authors: Charlotte
authors: C
authors: Madsen
authors: Colin
authors: C
authors: Summers
authors: Eva
authors: E
authors: Sodergren
authors: Jorgen
authors: J
authors: Dahlstrom
authors: Titia
authors: T
authors: Lindner
authors: Sigurveig T
authors: ST
authors: Sigurdardottir
authors: Doreen
authors: D
authors: McBride
authors: Thomas
authors: T
authors: Keil
mesh_terms: D000328:Adult; D002648:Child; D005512:Food Hypersensitivity / Q000453:epidemiology*; D005638:Fruit / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D009754:Nuts / Q000009:adverse effects / Q000276:immunology; D010944:Plants / Q000009:adverse effects* / Q000276:immunology*; D015995:Prevalence; D014675:Vegetables / Q000009:adverse effects / Q000276:immunology