Sulpha allergy in lupus patients: a clinical perspective.
Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patients. European-American lupus patients with sulpha allergy are about two times more likely to suffer from lymphopenia, two times more likely to have anti-Ro autoantibody, and four times less likely to have anti-nRNP antibodies compared with lupus patients without a reported sulpha allergy (P = 0.0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005).
Jeffries
M
M
College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Bruner
G
G
Glenn
S
S
Sadanandan
P
P
Carson
C W
CW
Harley
J B
JB
Sawalha
A H
AH
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D012261:Ribonucleoproteins / Q000276:immunology; D013449:Sulfonamides / Q000009:adverse effects*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D012261:Ribonucleoproteins; C035356:SS-A antibodies; D013449:Sulfonamides