Pre-formed donor-specific alloantibodies (DSA) detected only by luminex technology using HLA-coated microspheres and causing acute humoral rejection and kidney graft dysfunction.
The different methodologies for the detection of HLA sensitization could have discrepant results. At the moment, luminex technology seems--in our opinion--to be the most sensitive and safest method for antibody detection, and it should be taken into account during the transplantation process and as a means of indicating immunossuppresive regimen modulation.
Muro
Manuel
M
Departments of Immunology, University Hospital Virgen de la Arrixaca, Spain.
Llorente
Santiago
S
Gónzalez-Soriano
Maria J
MJ
Minguela
Alfredo
A
Gimeno
Luisa
L
Alvarez-López
María R
MR
D000917:Antibody Formation; D000918:Antibody Specificity; D004359:Drug Therapy, Combination; D017707:Erythrocyte Transfusion; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007518:Isoantibodies / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008863:Microspheres; D008875:Middle Aged; D012086:Reoperation; D014019:Tissue Donors
D006680:HLA Antigens; D007166:Immunosuppressive Agents; D007518:Isoantibodies