Pharmacokinetics/Pharmacodynamics for critical care clinicians.
For appropriate antibiotic therapy and selection, the clinician must be familiar with pharmacodynamic concepts that integrate an antibiotic's microbiologic activity, pharmacokinetic properties, and mode of bacterial killing. Much of the traditional dosing methods that continue to this day are based more on habit rather than science. This article addresses these issues and explains the basis for the new scientific ways to administer antibiotics to optimize patient outcomes.
Quintiliani
Richard
R
University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA. rqmdid@aol.com
Quintiliani
Richard
R
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D001682:Biological Availability; D003422:Critical Care / Q000379:methods*; D006207:Half-Life; D006801:Humans; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents