title: [Prevalence of primary resistance mutations in patients with newly diagnosed HIV infection in the province of Málaga (Spain)].
abstract: BACKGROUND
  The reported prevalence of primary resistance mutations differs between studies. An analysis was performed to determine the prevalence of primary resistance mutations and HIV subtypes in our area.
  
  
  METHODS
  Prospective study performed in all patients diagnosed with HIV in the year 2005 in the province of Malaga (Spain). Plasma samples from these patients were tested for genotypic resistance (TruGene HIV-1 genotyping kit; Bayer Healthcare Diagnostics) and HIV subtype.
  
  
  RESULTS
  A total of 172 cases were diagnosed, 6 of them recent seroconvertors. Genotype resistance testing disclosed resistance mutations in 7.8% (95% CI 3.5-12.0%) of 153 patients in which it was performed (6 to NNRTIs, 4 to NRTIs, and 3 to PIs). HIV subtype was B in 81.8% of patients, and non-B in 18.1% (51.8% of them of sub-Saharan origin, in whom the prevalence of this subtype was 73.6%). Among European patients, only those from Spain presented the non-B subtype (prevalence 7.4%). The only factor related with the presence of resistance mutations was seroconversion (OR 9.2; 95% CI 1.3-61.9; P < .02).
  
  
  CONCLUSIONS
  There was a considerable prevalence of primary resistance mutations in patients with newly diagnosed HIV infection in Malaga province, with seroconversion being the only related factor. The high prevalence of the non-B HIV subtype in the Spanish population is noteworthy. Genotype resistance testing is recommendable in all newly diagnosed HIV patients in our area.
authors: Unidad de Enfermedades Infecciosas, Hospital Virgen de la Victoria, Málaga, Spain.
authors: Rosario
authors: R
authors: Palacios
authors: Isabel
authors: I
authors: Viciana
authors: Iván
authors: I
authors: Pérez de Pedro
authors: Javier
authors: J
authors: de la Torre
authors: Fátima
authors: F
authors: Ropero
authors: Sonsoles
authors: S
authors: Fernández
authors: Fernando
authors: F
authors: Salgado
authors: Juan
authors: J
authors: Roldán
authors: Juan
authors: J
authors: de Dios Colmenero
authors: Manuel
authors: M
authors: Márquez
authors: Jesús
authors: J
authors: Santos
mesh_terms: D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D011446:Prospective Studies; D013030:Spain