title: Pregnancy in patients with myelodysplastic syndromes (MDS).
abstract: We report 6 pregnancies in 5 females with low-risk myelodysplastic syndromes (MDS) (median age at diagnosis 28 years, range 26-29) observed in the last 15 years. In 2 cases pregnancy was concomitant to the diagnosis of MDS, in the remaining 4 cases the intervals from diagnosis were 2, 3, 4 and 9 years, respectively. One patient had a foetal growth retardation corrected with steroid treatment while the remaining 5 pregnancies were uneventful. After a median time from delivery of 104 months (range 18-187) none of the patients developed acute myeloid leukemia (AML) and all are alive in stable disease. In conclusion, selected females with low-risk MDS could not be discouraged to have full term pregnancies.
authors: Dipartimento di Biotecnologie Cellulari ed Ematologia, Università La Sapienza di Roma, Italy.
authors: P
authors: P
authors: Volpicelli
authors: R
authors: R
authors: Latagliata
authors: M
authors: M
authors: Breccia
authors: I
authors: I
authors: Carmosino
authors: C
authors: C
authors: Stefanizzi
authors: L
authors: L
authors: Napoleone
authors: F
authors: F
authors: Vozella
authors: A
authors: A
authors: Levi
authors: F
authors: F
authors: Natalino
authors: G
authors: G
authors: Alimena
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000175:diagnosis*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis*; D011256:Pregnancy Outcome