Electroporation for drug and gene delivery in the clinic: doctors go electric.
Electroporation is a unique system for drug and gene delivery, as it is possible to very specifically target certain tissues within the body with whatever drug, gene, isotope, or other product is desired in a specific situation. An increasing number of clinical trials are being launched, and sophistication of equipment and protocols continues. This chapter reviews present knowledge from clinical trials, describes important issues in the patient management when using electroporation, and outlines future perspectives of the technology.
Gehl
Julie
J
Department of Oncology, Copenhagen University Hospital at Herlev, Herlev Ringvej, Denmark.
D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D004274:DNA, Recombinant / Q000008:administration & dosage / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods*; D053672:Electrochemotherapy / Q000295:instrumentation / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D016896:Treatment Outcome
D004274:DNA, Recombinant