[Efficacy of pulmicort suspension plus salbutamol and ipratropium bromide for management of acute asthma exacerbation in children: a comparative study].
OBJECTIVE
To evaluate the efficacy of 3 commonly used protocols for management of acute exacerbation of asthma in children.


METHODS
Totally 113 asthmatic children were randomized into 3 groups. In group A (53 cases), the children were treated with inhalation of nebulized budesonide suspension plus salbutamol and ipratropium bromide twice daily for 5 days; in group B (41 cases), budesonide plus salbutamol and ipratropium aerosol was administered, and in group C (29 cases), dexathmisone plus aminophylline injection was given once daily for 5 days. All the children received basic treatment with fluid infusion, antibiotics or/and anti-virus medications.


RESULTS
The children in both groups A and C showed effectively controlled asthma attack, with significant differences in the therapeutic effects (P>0.05). In contrast, only a few children showed improvement in group B, suggesting the ineffectiveness of the treatment.


CONCLUSIONS
Nebulized medicine is one of the best means for management of acute asthma exacerbation in children, and inhalation of budesonide suspension plus salbutamol and ipratropium bromide can effectively relieve the asthmatic symptoms in these children with good compliance and convenient administration.
Chen
Zhuang-gui
ZG
Department of Pediatrics, Third Hospital Affiliated to Sun Yat-sen University, Guangzhou 510630, China. chenzhuanggui@126.com
Li
Ming
M
Chen
Hong
H
Chen
Yan-feng
YF
Chen
Fen-hua
FH
Ji
Jing-zhi
JZ
D000208:Acute Disease; D000293:Adolescent; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D009241:Ipratropium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
D000336:Aerosols; D001993:Bronchodilator Agents; D019819:Budesonide; D009241:Ipratropium; D000420:Albuterol