Temporal lobe neoplasm and seizures: how deep does the story go?
[March 2008-Cleveland Case Report]. There is a well-described association between the occurrence of developmental tumors and the presence of cortical dysplasia in the neighboring brain tissue. The main surgical approaches in the treatment of medically refractory epilepsy related to such developmental tumors include a lesionectomy versus a tailored cortical resection, often guided by an invasive evaluation. This case report describes the surgical management of a 26-year-old female with olfactory auras evolving into automotor seizures and convulsions, occurring in the context of a right temporo-parietal developmental lesion. It illustrates the pros and cons of various surgical approaches, and discusses some pathophysiological aspects of developmental tumors, dysplasia and epilepsy. [Published with video sequences].
Jehi
Lara E
LE
Epilepsy Center, Cleveland Clinic Foundation, Ohio 44195, USA. jehil@ccf.org
Lüders
Hans O
HO
Naugle
Richard
R
Ruggieri
Paul
P
Morris
Harold
H
Foldvary
Nancy
N
Wyllie
Elaine
E
Kotagal
Prakash
P
Bingaman
Bill
B
Dinner
Dudley
D
Prayson
Richard
R
Diehl
Beate
B
Alexopoulos
Andreas
A
Bautista
Jocelyn
J
Busch
Robyn
R
D000328:Adult; D000654:Amobarbital; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D004292:Dominance, Cerebral; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures; D012640:Seizures / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology; D016896:Treatment Outcome
D006993:Hypnotics and Sedatives; D000654:Amobarbital