title: [Oncological and reconstructive management in a patient with multiple recurrences of basal cell carcinoma of the nose].
abstract: Basal cell carcinoma (BCC) grows by direct extension replacing local anatomical structure; it rarely metastasizes, however may cause severe injure expanding to contiguous tissues with a biological invasive behaviour. BCC of the nose is often a highly aggressive neoplasia with infiltrative growth pattern. Fast cancer extension to the adjacent facial structures requires wide resection for oncological management. In our study we present a 69-year-old male affected by BCC of the nose back and treated by surgical radical excision with free margin disease at histological examination. Patient, subsequently, developed a local relapse. Therefore, he underwent surgical excision of the recurrence and the histological evaluation pointed out a metatypical and infiltrative BCC pattern without margins involvement. Afterwards, the patient developed another local recurrence involving the left alar nose and the omolateral cheek. Histological examination still demonstrated a metatypical and infiltrative pattern, with disease free margins, but nasal vestibule involvement. Successively the patient had another local wide resection from the nasal wing to the maxillary bone without reconstructive procedure. Three years after, the patient developed another local relapse and underwent another surgical procedure, consisting in a very wide resection with concomitant selective left laterocervical node dissection. Histological evaluation demonstrated a metatypical solid infiltrative BCC pattern with disease free margins and lymph nodes. One year after, forehead flap was made to reconstruct the nose and left cheek deficit. At 16 months follow-up the patient remains disease free.
authors: Università degli Studi di Roma "La Sapienza", Dipartimento di Dermatologia e Chirurgia Plastica Ricostuttiva.
authors: C
authors: C
authors: Monarca
authors: S
authors: S
authors: Chiummariello
authors: P
authors: P
authors: Mazzana
authors: M I
authors: MI
authors: Rizzo
authors: C
authors: C
authors: Alfano
authors: N
authors: N
authors: Scuderi
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D002610:Cheek / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009666:Nose / Q000473:pathology; D009669:Nose Neoplasms / Q000473:pathology / Q000601:surgery*; D019651:Plastic Surgery Procedures; D013524:Surgical Flaps; D013997:Time Factors; D016896:Treatment Outcome