Sarcoidosis as risk factor for cryptococcal meningitis in an apparently immunocompetent patient.
Cryptoccus neoformans meningitis (CNM) is an opportunistic infection that typically occurs in immunosuppressed patients. Subjects affected by sarcoidosis, a systemic granulomatous disease of unknown cause, are predisposed to CNM because of the impairment of cell-mediated immunity and because of the chronic corticosteroid therapy they frequently receive. Here we report the case of a 38-year-old man who developed CNM as the first clinical manifestation of sarcoidosis. The patient developed CNM even though he was apparently immunocompetent and was not on therapy with either corticosteroid or cytotoxic drugs.
Cancelli
Iacopo
I
Department of Neurology, S. Maria della Misericordia University Hospital, Piazza S. Maria della Misericordia, 33100 Udine, Italy.
Merlino
Giovanni
G
Serafini
Anna
A
Valente
Mariarosaria
M
Gigli
Gian Luigi
GL
D000328:Adult; D000666:Amphotericin B; D000935:Antifungal Agents / Q000627:therapeutic use; D003455:Cryptococcus neoformans; D017809:Fatal Outcome; D005437:Flucytosine; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012307:Risk Factors; D017565:Sarcoidosis, Pulmonary / Q000150:complications*
D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine