Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease.
Two patients with moderate Huntington's disease (HD) received bilateral fetal striatal allografts. One patient demonstrated, for the first time, increased striatal D2 receptor binding, evident with 11C-raclopride positron emission tomography, and prolonged clinical improvement over 5 years, suggesting long term survival and efficacy of the graft. The other patient did not improve clinically or radiologically. Our results indicate that striatal transplantation in HD may be beneficial but further studies are needed to confirm this.
Reuter
I
I
Academic Department of Neuroscience, Kings College Hospital, London, UK.
Tai
Y F
YF
Pavese
N
N
Chaudhuri
K R
KR
Mason
S
S
Polkey
C E
CE
Clough
C
C
Brooks
D J
DJ
Barker
R A
RA
Piccini
P
P
D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use; D000328:Adult; D001929:Brain Edema / Q000000981:diagnostic imaging; D016380:Brain Tissue Transplantation; D002250:Carbon Radioisotopes; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000601:surgery*; D003131:Combined Modality Therapy; D003342:Corpus Striatum / Q000196:embryology* / Q000637:transplantation*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D018492:Dopamine Antagonists; D005260:Female; D016332:Fetal Tissue Transplantation; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging* / Q000601:surgery*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008218:Lymphocytosis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011699:Putamen / Q000000981:diagnostic imaging / Q000601:surgery*; D020891:Raclopride; D000077593:Reboxetine; D013238:Stereotaxic Techniques; D014022:Tissue Survival / Q000502:physiology
D018759:Adrenergic Uptake Inhibitors; D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D007166:Immunosuppressive Agents; D009025:Morpholines; D020891:Raclopride; D016572:Cyclosporine; D000077593:Reboxetine