title: Prospective 2-years follow-up quality of life study after infrageniculate bypass surgery for limb salvage: lasting improvements only in non-diabetic patients.
abstract: OBJECTIVE
  To assess health-related quality of life (HRQoL) up to 24 months after successful infrageniculate bypass surgery for limb-threatening ischaemia.
  
  
  METHODS
  89 patients with infrageniculate bypass surgery for limb-salvage were studied. HRQoL was assessed using the Short Form (SF)-36v1 questionnaire before, 6, 12, and 24 months after revascularisation.
  
  
  RESULTS
  47 patients (53%) with intact limb and functioning graft were assessed after 24 months, 27 patients (30%) died, further 7 required secondary amputation, 3 suffered irremediable graft occlusion, and 4 were lost to follow-up. The 24-months HRQoL-values were significantly improved in 4 domains: physical functioning (p<0.01), bodily pain (p<0.01), mental health (p=0.04), and social functioning (p=0.01). Except for baseline-values, HRQoL remained inferior in diabetics compared to non-diabetics throughout follow-up. Maximum improvement of HRQoL was delayed in diabetics (12 months vs. 6 months) and less pronounced. After 24 months non-diabetic patients maintained improvement in 5 domains and diabetic patients only in bodily pain.
  
  
  CONCLUSIONS
  Improvement in HRQoL is sustained for more than 12 months after successful infrageniculate bypass surgery. Therefore, an aggressive approach towards revascularisation seems to be justified from the patient's perspective. However, this benefit in quality of life is less in diabetic patients, despite similar limb-salvage rates.
authors: Division of Vascular Surgery, Military Hospital Ulm, Germany. m-engelhardt@web.de
authors: M
authors: M
authors: Engelhardt
authors: H
authors: H
authors: Bruijnen
authors: C
authors: C
authors: Scharmer
authors: W A
authors: WA
authors: Wohlgemuth
authors: C
authors: C
authors: Willy
authors: K D
authors: KD
authors: Wölfle
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D019917:Blood Vessel Prosthesis Implantation; D048909:Diabetes Complications / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000503:physiopathology / Q000601:surgery; D006305:Health Status Indicators; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D023821:Limb Salvage; D008297:Male; D017060:Patient Satisfaction; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D011788:Quality of Life; D020127:Recovery of Function; D012086:Reoperation; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency