title: [Application of real-time gray-scale contrast-enhanced ultrasound in the diagnosis of benign and malignant breast lesions].
abstract: OBJECTIVE
  To observe the patterns of benign and malignant breast lesions using real-time gray-scale contrast-enhanced ultrasound and assess its value in the differential diagnosis of begign and malignant breast tumors.
  
  
  METHODS
  Totally 116 breast lesions (benignity n = 63; malignancy n = 53) underwent real-time gray-scale contrast-enhanced ultrasound. The patterns of their enhancement were assessed from 6 aspects: degree of enhancement, process of enhancement, completeness of enhancement, homogeneity of enhancement, boundary of the enhanced lesions, and exhistance of radial enhancement around the lesions. The results were compared with the pathologic findings.
  
  
  RESULTS
  Contrast-enhanced sonographic patterns were significantly different between benign and malignant breast lesions. Most malignant lesions were non-centripetally, incompletely, and inhomogeneously enhanced. After having been injected with the microbubble contrast medium, the boundary of the lesions became unclear, and the radial enhancement around lesion were mainly seen in the malignant lesions.
  
  
  CONCLUSIONS
  The patterns of real-time gray-scale contrast-enhanced ultrasound are remarkably different between malignant and benign breast lesions, showing promising values for its clinical application.
authors: Department of Ultrosonography, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Jing
authors: J
authors: Zhang
authors: Yu-Xin
authors: YX
authors: Jiang
authors: Qing
authors: Q
authors: Dai
authors: Qiang
authors: Q
authors: Sun
authors: Ke
authors: K
authors: Lü
authors: Li
authors: L
authors: Tan
authors: Pin
authors: P
authors: Gao
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D045423:Microbubbles; D016217:Ultrasonography, Mammary
chemical_list: D003287:Contrast Media