Are hematopoietic stem cells generated in the placenta?
In this issue of Cell Stem Cell, the origin of multipotent hematopoietic cells present in the placenta has been assessed in Ncx1(-/-) embryos lacking a functional heart and circulation. Rhodes and colleagues (Rhodes et al., 2008) found lymphoid progenitors in the placenta, as well as in dorsal aorta and yolk sac and vitelline vessels, indicating that they arose in situ.
Kieusseian
Aurelie
A
Department of Immunology, Pasteur Institute, 25 rue du Dr. Roux, Paris 75015, France.
Cumano
Ana
A
D000818:Animals; D019070:Cell Lineage / Q000502:physiology; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008099:Liver / Q000166:cytology / Q000196:embryology*; D051379:Mice; D018345:Mice, Knockout; D010920:Placenta / Q000098:blood supply* / Q000166:cytology; D040201:Platelet Membrane Glycoprotein IIb / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy / Q000502:physiology*; D019831:Sodium-Calcium Exchanger / Q000235:genetics / Q000378:metabolism
D050676:Core Binding Factor Alpha 2 Subunit; C499849:NCX1 protein, mouse; D040201:Platelet Membrane Glycoprotein IIb; C493726:Runx1 protein, mouse; D019831:Sodium-Calcium Exchanger