Human leukocyte antigen DRB1 alleles predict risk and disease progression of immunoglobulin A nephropathy in Han Chinese.
The role of human leukocyte antigen (HLA) class II polymorphisms in the pathogenesis and progression of primary immunoglobulin A nephropathy (pIgAN) is unclear. This study aimed to explore the relationship of HLA-DRB1 alleles with the susceptibility and disease progression of pIgAN in Han Chinese. A PCR-based genotyping technique was used to detect HLA-DRB1 alleles in 139 patients with pIgAN and 143 healthy subjects. A total of 37 HLA-DRB1 alleles were detected, of which 30 were found in pIgAN patients and 29 in healthy subjects. In pIgAN patients, the frequencies of HLA-DRB1*140501 (belonging to DR*14) were significantly increased, while the frequencies of HLA-DRB1*070101 (belonging to DR*7) were significantly reduced compared with the healthy individuals. Further stratification analysis revealed that the frequencies of HLA-DRB1*030101 in pIgAN patients with normal renal function were significantly higher than those in patients with renal dysfunction. These findings suggest that HLA-DRB1 polymorphisms are related to the occurrence and disease progression of pIgAN patients in Han Chinese, with HLA-DRB1*140501 being a susceptible allele and HLA-DRB1*070101 a resistant allele. HLA-DRB1*030101 may serve as a predictor of disease progression and renal damage of pIgAN in Han Chinese. Further studies are warranted to explore the immunological mechanisms for the genotype-disease phenotype relationship.
Cao
Hui-Xia
HX
Department of Nephropathy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li
Ming
M
Nie
Jing
J
Wang
Wie
W
Zhou
Shu-Feng
SF
Yu
Xue-Qing
XQ
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D019382:Human Growth Hormone; D006801:Humans; D008297:Male
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D019382:Human Growth Hormone