A new meroterpenoid pigment from the basidiomycete Albatrellus confluens.
A new farnesyl phenol named (+)-(R)-grifolinone C (1) has been isolated from the fruiting bodies of the basidiomycete Albatrellus confluens. (+)-(R)-Grifolinone C (1), a dimeric meroterpenoid, is accompanied by albatrellin (2), grifolinone B (3), grifolin (4), and grifolinone A (5). Albatrellin (2) exhibited cytotoxic activity against HepG2 human lung carcinoma cells with IC(50) value of 1.55 mug ml(-1). The structures were established on the basis of spectral evidence (IR, 1D- and 2D-NMR, and MS analyses).
Yang
Xiao-Long
XL
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.
Qin
Cheng
C
Wang
Fei
F
Dong
Ze-Jun
ZJ
Liu
Ji-Kai
JK
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D016227:Benzoquinones; D013729:Terpenes; C529604:grifolinone C