Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism.
The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5'' position.
Takizawa
Toshiya
T
Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Watanabe
Kazuhiro
K
Narita
Koichi
K
Oguchi
Takamasa
T
Abe
Hideki
H
Katoh
Tadashi
T
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D015394:Molecular Structure; D011549:Pseudomonas / Q000737:chemistry*
D000970:Antineoplastic Agents; D047630:Depsipeptides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; C529984:spiruchostatin B