Bone marrow stromal cells control the growth of hepatic stellate cells in vitro.
Liver cirrhosis is characterized by hepatic dysfunction, with extensive accumulation of fibrous tissue in the liver. Hepatic stellate cells (HSCs) are the major source of fibrillar matrix proteins and play an important role in the progress of liver cirrhosis. In our study, the growth of HSCs is inhibited by bone marrow stromal cells (BMSCs). The inhibition is irreversible and is followed by apoptosis. The effect of BMSCs on the apoptosis of HSCs is possibly via the JNK pathway activated by nerve growth factor (NGF) and hepatocyte growth factor (HGF) secreted by BMSCs. Meanwhile, the apoptosis effect is enhanced by transforming growth factor-beta blocking.
Shi
Lijun
L
Department of Gastroenterology, The First Affiliated Clinic College of Harbin Medical University, Heilongjiang, China.
Li
Guozhong
G
Wang
Jinghua
J
Sun
Bo
B
Yang
Liming
L
Wang
Guangyou
G
Wang
Dandan
D
Mu
Lili
L
Chen
Hui
H
Jin
Lianhong
L
Kostulas
Nikolaos
N
Li
Hulun
H
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D055166:Hepatic Stellate Cells / Q000166:cytology* / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism
D016212:Transforming Growth Factor beta; D017228:Hepatocyte Growth Factor; D020932:Nerve Growth Factor; D048670:MAP Kinase Kinase 4