Cell regulation by the Apc protein Apc as master regulator of epithelia.
The adenomatous polyposis coli (Apc) protein participates in many of the fundamental cellular processes that govern epithelial tissues: Apc is directly involved in regulating the availability of beta-catenin for transcriptional de-repression of Tcf/LEF transcription factors, it contributes to the stability of microtubules in interphase and mitosis, and has an impact on the dynamics of F-actin. Thus Apc contributes directly and/or indirectly to proliferation, differentiation, migration, and apoptosis. This particular multifunctionality can explain why disruption of Apc is especially detrimental for the epithelium of the gut, where Apc mutations are common in most cancers. We summarise recent data that shed light on the molecular mechanisms involved in the different functions of Apc.
McCartney
Brooke M
BM
Department of Biological Sciences, Carnegie Mellon University, 4400 5th Avenue, Pittsburgh, PA, USA.
Näthke
Inke S
IS
D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D002467:Cell Nucleus / Q000378:metabolism; D002468:Cell Physiological Phenomena; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D051153:Wnt Proteins / Q000378:metabolism
D025601:Adenomatous Polyposis Coli Protein; D051153:Wnt Proteins