[The impact of nitric oxide intoxication on hepatic metabolic reactions and the prevention of lesions].
Experimental studies were conducted on 4 groups of animals, each containing 20 rats: (1) intact animals (control); (2) the animals given inhaled nitric oxide at a concentration of 4.3 mg/m3 for 6 min; (3) those were prophylactically administered amtizole (40 mg/kg 30 min before inhalation of nitric oxide with further 6-min inhalation; (4) those receiving Eleutherococcus for 3 weeks, followed by amtizole administration 30 min before nitric oxide inhalation and with further 6-min inhalation. After nitric oxide inhalation, animals' survival was 16%; the preadministration of amtizole enhanced the survival up to 50%; co-administration of Eleutherococcus and amtizole contributed to 80% survival. Inhalation of nitric oxides at a concentration of 4.3 mg/m3 resulted in the impairment of hepatic xenobiotic detoxification system, the development of tissue hypoxia, fatty infiltration, and deterioration of hepatic etherifying function. Preadministration of the antihypoxant amtizole prior to inhalation favored less hepatic dysfunction. Preadministration of Eleutherococcus and further amtizole administration have a protective effect on hepatic antitoxic function and lipid metabolism.
Kushnerova
N F
NF
Rakhmanin
Iu A
IuA
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control; D008107:Liver Diseases / Q000378:metabolism / Q000517:prevention & control; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000506:poisoning*; D051381:Rats; D013830:Thiadiazoles / Q000008:administration & dosage / Q000494:pharmacology
D013830:Thiadiazoles; D009569:Nitric Oxide; C044365:amtizol