title: Control-matched analysis of laser in situ keratomileusis outcomes in high myopia.
abstract: OBJECTIVE
  To evaluate the outcomes of laser in situ keratomileusis (LASIK) for high myopia.
  
  
  METHODS
  Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
  
  
  METHODS
  The refractive and visual outcomes in 320 eyes (227 patients) that had LASIK for high myopia (spherical equivalent [SE] -6.00 to -10.00 diopters [D]) were analyzed. Two hundred fifty-eight eyes that had LASIK for low myopia were reviewed, and a subsequent control-matched comparative analysis of visual outcomes in highly myopic eyes (SE -7.54 +/- 1.43 D) versus low myopic eyes (SE -2.26 +/- 0.51 D) was performed after controlling for preoperative and surgical parameters. Descriptive and control-matched analyses of eyes with thick corneal pachymetry (> or =570 microm) versus eyes with thinner corneal pachymetry (< or =530 microm) were performed to evaluate the influence of corneal pachymetry on visual outcomes of LASIK for high myopia.
  
  
  RESULTS
  The postoperative uncorrected visual acuity (Snellen; mean -logMAR +/- SD) in the low myopia group (20/22; 0.04 +/- 0.11) was statistically significantly better than in the high myopia group (20/26; 0.11 +/- 0.18) (P = .006). More eyes in the low myopia group (84.7%) than in the high myopia group (56.9%) achieved an SE within +/-0.5 D (P<.001). There were no significant differences in visual and refractive outcomes between the thin and thick cornea groups.
  
  
  CONCLUSIONS
  Laser in situ keratomileusis for high myopia was safe, although the efficacy and predictability was slightly lower than for low myopia. There was no relationship between preoperative pachymetry and visual and refractive outcomes.
authors: Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, IL 60612, USA.
authors: Takashi
authors: T
authors: Kojima
authors: Joelle A
authors: JA
authors: Hallak
authors: Dimitri T
authors: DT
authors: Azar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003319:Corneal Stroma / Q000601:surgery*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D008297:Male; D047728:Myopia, Degenerative / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D013524:Surgical Flaps; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology