Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?
Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.
Friscić
Tomislav
T
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Fábián
László
L
Burley
Jonathan C
JC
Reid
David G
DG
Duer
Melinda J
MJ
Jones
William
W
D002110:Caffeine / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004355:Drug Stability; D006860:Hydrogen Bonding; D008293:Malates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry*; D013806:Theophylline / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D008293:Malates; D013644:Tartrates; D014867:Water; D002110:Caffeine; C030298:malic acid; D013806:Theophylline; C029768:tartaric acid