Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population.
BACKGROUND
Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity.


OBJECTIVE
We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population.


METHODS
The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis.


RESULTS
There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01-2.52, <0.05).


CONCLUSIONS
The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.
Wang
Fang-Yu
FY
Department of Gastroenterology, Fujita Health University School of Medicine, Aichi Prefecture, 470-1192, Japan.
Tahara
Tomomitsu
T
Arisawa
Tomiyasu
T
Shibata
Tomoyuki
T
Yamashita
Hiromi
H
Nakamura
Masakatsu
M
Yoshioka
Daisuke
D
Okubo
Masaaki
M
Maruyama
Naoko
N
Kamano
Toshiaki
T
Kamiya
Yoshio
Y
Nakamura
Masahiko
M
Fujita
Hiroshi
H
Nagasaka
Mitsuo
M
Iwata
Masami
M
Takahama
Kazuya
K
Watanabe
Makoto
M
Nakano
Hiroshi
H
Hirata
Ichiro
I
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000235:genetics*; D055815:Young Adult
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin