title: Severe retinopathy of prematurity and visual outcomes in British Columbia: a 10-year analysis.
abstract: OBJECTIVE
  To describe the incidence trend and long-term visual outcomes of infants diagnosed with stages 3 to 4 retinopathy of prematurity (ROP) or laser-treated ROP born in British Columbia (Canada).
  
  
  METHODS
  Data from all (n=1384) neonates with birth weight (BW) <1250 g, admitted to British Columbia Children's Hospital between period 1 (January 1992 to December 1996) and period 2 (January 1997 to December 2001) were analyzed. Ophthalmologic records of infants with stages 3 to 4 ROP or laser-treated ROP were abstracted. chi(2)- and t-test were used to compare neonatal characteristics between periods. Logistic regression was used to identify risk factors associated with visual impairment (defined as visual acuity <or=20/60 or visual field restriction of 20 degrees binocularly).
  
  
  RESULTS
  Of 1159 surviving infants, 887 were examined for acute ROP (473 in period 1, 414 in period 2). Stages 3 to 4 ROP or laser-treated ROP were present in 35 infants in period 1 (7%) and 59 in period 2 (14%), P<or=0001. Infants born in period 2 had lower mean BW and gestational age. Among infants who developed severe ROP or laser-treated ROP, binocular visual impairment was present in eight children in period 1 and seven in period 2. Refractive errors, including myopia and astigmatism, were increased in period 2. Children who developed periventricular leucomalacia had the highest risk of visual impairment at 4 to 6 years of age.
  
  
  CONCLUSIONS
  During the 10-year study period, a significant increase in rates of stages 3 to 4 or laser-treated ROP was not associated with increases in visual impairment rates.
authors: Department of Pediatrics, Sunny Hill Health Centre, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada. vschiariti@cw.bc.ca
authors: V
authors: V
authors: Schiariti
authors: C
authors: C
authors: Matsuba
authors: J S
authors: JS
authors: Houbé
authors: A R
authors: AR
authors: Synnes
mesh_terms: D001766:Blindness / Q000453:epidemiology*; D001955:British Columbia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D053685:Laser Therapy; D012030:Refractive Errors / Q000453:epidemiology*; D012178:Retinopathy of Prematurity / Q000453:epidemiology* / Q000628:therapy; D012189:Retrospective Studies