Time-dependent ventilatory response to poikilocapnic hypoxia during light and dark periods and the role of histamine H1 receptors in mice.
We tested the hypothesis that the biphasic ventilatory response to poikilocapnic hypoxia shows circadian variation and contribution of histamine H1 receptors in mice. Initial increases in ventilation were augmented during dark periods. H1 receptors had no major relationship with circadian variation, but affected the declined phase.
Ohshima
Yasuyoshi
Y
Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan.
Iwase
Michiko
M
Izumizaki
Masahiko
M
Kanamaru
Mitsuko
M
Homma
Ikuo
I
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010100:Oxygen / Q000378:metabolism; D017440:Photoperiod; D012123:Pulmonary Ventilation / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000235:genetics / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D013997:Time Factors
D011969:Receptors, Histamine H1; D002245:Carbon Dioxide; D010100:Oxygen