Haematopoietic properties of ethanolic extract of Ageratum conyzoides (goat weed) in albino rats.
The potential haematological effects associated with the administration of ethanolic leaf extract of Ageratum conyzoides was investigated in rats. 27 rats were randomly divided into four groups. The first group had 6 rats and served as control, the remaining 3 experimental groups and had 7 rats each. These later groups were gavaged with the extract of Ageratum conyzoides in concentrations of 200 mg/kg, 400 mg/kg and 500 mg/kg respectively for 30 days at a dose of 0.1 ml/body weight. The control group was gavaged with 0.9% sodium chloride at a dose of 0.1 m1/body weight as placebo. The extract at the doses administered was found to increase in a dose-related fashion PCV and Hb ([P < 0.01] for 200 mg/kg and [P < 0.001] for 400 mg/kg and 500 mg/kg), RBC ([P < 0.05] for 400 mg/Kg and 500 mg/kg) and marginal increases that were not significant for 200 mg/kg); MCH and MCV ([P < 0.05] and [P < 0.01] for 400 mg/kg and 500 mg/kg respectively) 200 mg/kg was not significant. MCHC recorded no significant change. WBC recorded marginal increases that were not significant, similarly, the differential white blood cell recorded marginal increases that were not significant, except lymphocytes that recorded significant increase in group 4 [P < 0.05]. Marginal decreases in body weight were also observed, these decreases were however not significant. The result of this study thus indicate haematopoietic potentials of the extract and could possibly remedy anaemia.
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Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria.
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D031163:Ageratum; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D000431:Ethanol / Q000737:chemistry; D005260:Female; D006397:Hematinics / Q000302:isolation & purification / Q000494:pharmacology*; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
D006397:Hematinics; D006454:Hemoglobins; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol