Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28.18H2O.
We have reported the synthesis and biological evaluation of a decavanadate Na(4)Co(H(2)O)(6)V(10)O(28).18H(2)O (CoV(10)) designed as a potential antitumoral agent. The human cancer cell lines SMMC-7721 (liver cancer) and SK-OV-3 (ovary cancer) were tested for their viability by the MTT method in vitro, which showed that the compound exhibited a remarkable activity against two cell lines with IC(50) values smaller than 0.24 microg/mL, 0.32 microg/mL, respectively. CoV(10) showed the tumor growth suppression for Hep-A-22 (mice liver cancer) in tumor bearing mice in vivo. In addition, using flow cytometry analysis, the ratio of apoptotic cells was up to 8.33% with treatment of CoV(10) at 1.56 microg/mL after 30 min, suggesting that the antitumoral activity of CoV(10) comes from the activation of the apoptotic pathway.
Zhai
Fengying
F
Key laboratory of Polyoxometalate Science of Ministry of Education, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, PR China.
Wang
Xiaohong
X
Li
Dongliu
D
Zhang
He
H
Li
Rui
R
Song
Liansheng
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D014638:Vanadates / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014638:Vanadates