title: Patients with chronic tension-type headache demonstrate increased mechano-sensitivity of the supra-orbital nerve.
abstract: OBJECTIVE
  This study aimed to establish whether increased sensitivity to mechanical stimuli is present in neural tissues in chronic tension-type headache (CTTH).
  
  
  BACKGROUND
  Muscle hyperalgesia is a common finding in CTTH. No previous studies have investigated the sensitivity of peripheral nerves in patients with CTTH.
  
  
  METHODS
  A blinded controlled study.
  
  
  METHODS
  Pressure pain thresholds (PPT) and pain intensity following palpation of the supra-orbital nerve (V1) were compared between 20 patients with CTTH and 20 healthy matched subjects. A pressure algometer and numerical pain rate scale were used to quantify PPT and pain to palpation. A headache diary was kept for 4 weeks to substantiate the diagnosis and record the pain history.
  
  
  RESULTS
  The analysis of variance demonstrated significantly lower PPT for patients (0.86+/-0.13 kg/cm2) than controls (1.50+/-0.19 kg/cm2) (P<.001). Pain to palpation was also higher for patients (2.73+/-1.58) than controls (0.15+/-0.28) (P<.001). Within the CTTH group, intensity, frequency, and duration of the headaches were negatively correlated with PPT (rs<or=-0.75; P<.001), and positively correlated with pain to palpation (rs>or=0.72; P<.001).
  
  
  CONCLUSIONS
  These findings reveal that mechanical hypersensitivity is not limited to muscles but also occurs in cranial nerves, and that the level of sensitization, either due to peripheral or central processes, is related to the severity of the primary headache.
authors: Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation of Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
authors: César
authors: C
authors: Fernández-de-Las-Peñas
authors: Michel W
authors: MW
authors: Coppieters
authors: María Luz
authors: ML
authors: Cuadrado
authors: Juan A
authors: JA
authors: Pareja
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005546:Forehead / Q000294:innervation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000503:physiopathology*; D009882:Ophthalmic Nerve; D010147:Pain Measurement; D017288:Pain Threshold; D010173:Palpation; D010812:Physical Stimulation; D018781:Tension-Type Headache / Q000503:physiopathology*