title: Oxybutynin effects on Staphylococcus epidermidis biofilm production.
abstract: BACKGROUND
  Oxybutynin is a tertiary amine and has chemical similarities like protamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to investigate the effect of oxybutynin on bacterial viability.
  
  
  METHODS
  Twenty of Staphylococcus epidermidis (S. epidermidis) strains were isolated from patients who had catheter-associated urinary tract infection. These strains were exposed to 5 different concentrations of oxybutynin in tryptic soy broth (TSB) media (max: 5 mg/mL, min: 0.05 mg/mL). Quantitative growth patterns were measured by spectrophotometer. Under the same media conditions, biofilm production of individual strains was measured by Deighton's micromethod at the end of the 6-hour incubation period.
  
  
  RESULTS
  After the incubation period, weak and strong slime-producing bacteria groups were obtained and both groups' slime productions were extensively low at 5 mg/mL concentration of oxybutynin. Slime production of S. epidermidis was inversely correlated with oxybutynin concentrations.
  
  
  CONCLUSIONS
  Although there was a dose-dependent reduction of biofilm production, there seemed to be no bactericidal effect of oxybutynin on S. epidermidis.
authors: Department of Urology, Diyarbakir Hospital, Urology Clinic, Diyarbakir, Turkey.
authors: Abdullah
authors: A
authors: Gedik
authors: Ahmet
authors: A
authors: Ersay
authors: Selahattin
authors: S
authors: Atmaca
authors: Alper
authors: A
authors: Sener
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology*; D018678:Cholinergic Agents / Q000494:pharmacology*; D006801:Humans; D008333:Mandelic Acids / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D018678:Cholinergic Agents; D008333:Mandelic Acids; C005419:oxybutynin