title: Invasive pneumococcal disease: epidemiology in children and adults prior to implementation of the conjugate vaccine in the Oxfordshire region, England.
abstract: A 10-year invasive pneumococcal disease (IPD) enhanced surveillance project in the Oxfordshire region of the UK between 1996 and 2005 identified a total of 2691 Streptococcus pneumoniae isolates from all ages that provided a comprehensive description of pneumococcal epidemiology. All isolates were serotyped and those from children under 5 years of age were genotyped and a matched case-control study using adults hospitalized between 1995 and 2000 was performed to estimate the effectiveness of the pneumococcal polysaccharide vaccine in the local population. Fifty-one serotypes were isolated, with different age distributions. The overall incidence of IPD was 9.2 cases per 100 000 population per annum [95 % confidence interval (CI), 8.6-9.9] and that of meningitis was 0.7 per 100 000 population per annum (95 % CI 0.5-0.9). After adjusting for age, serotype 1 was found to be less likely to be associated with meningitis versus other IPD, compared with the most common serotype 14, whereas serotype 12F was more likely to cause meningitis than other IPD. There were significant temporal changes in IPD incidence of four serotypes, with decreases in serotypes 1, 12F and 14 and increases in serotype 8. A possible novel variant (from serotype 6A to 6B) was found using multilocus sequence typing analysis. From the matched case-control study of adults, the pneumococcal polysaccharide vaccine effectiveness was estimated to be 43 % (2-68 %), which did not change significantly after adjustment for pre-existing co-morbidities. The data provide a baseline against which the impact of the pneumococcal conjugate vaccine introduced in the UK in 2006 could be measured.
authors: Thames Valley Health Protection Unit, Health Protection Agency, Oxford, UK.|Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: Dona
authors: D
authors: Foster
authors: Division of Public Health and Primary Health Care, University of Oxford, Headington, Oxford OX3 7LF, UK.
authors: Kyle
authors: K
authors: Knox
authors: Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: A S
authors: AS
authors: Walker
authors: Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: D T
authors: DT
authors: Griffiths
authors: Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: Hazel
authors: H
authors: Moore
authors: Thames Valley Health Protection Unit, Health Protection Agency, Oxford, UK.
authors: Elizabeth
authors: E
authors: Haworth
authors: Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: Timothy
authors: T
authors: Peto
authors: Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
authors: Angela B
authors: AB
authors: Brueggemann
authors: Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: Derrick W
authors: DW
authors: Crook
authors: Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
authors: On Behalf Of The Oxford Invasive Pneumococcal Surveillance Group
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000382:microbiology; D008875:Middle Aged; D017720:Molecular Epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D011159:Population Surveillance / Q000379:methods*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate