title: Histologic evaluation of a cornea in a patient with apolipoprotein A-I deficiency.
abstract: OBJECTIVE
  To report the histology of a cornea in a patient with apolipoprotein A-I (apoA-I) deficiency.
  
  
  METHODS
  A cornea from a patient with apoA-I deficiency was obtained by keratoplasty and examined histologically.
  
  
  RESULTS
  There were many small vesicles in the extracellular matrix throughout the corneal stroma. The vesicles were round or oval, and their diameters ranged from 200 nm to 2 microm. These histologic properties suggest that the small vesicles are lipid droplets.
  
  
  CONCLUSIONS
  Myriad lipid droplets in the extracellular matrix in the corneal stroma induce diffuse corneal opacity in a patient with apoA-I deficiency.
authors: Department of Pathology, Tokyo Medical University, Tokyo, Japan.
authors: Yasuhiro
authors: Y
authors: Osakabe
authors: Shiro
authors: S
authors: Amano
authors: Shima
authors: S
authors: Fukuoka
authors: Satoru
authors: S
authors: Yamagami
mesh_terms: D000368:Aged; D016632:Apolipoprotein A-I / Q000172:deficiency* / Q000235:genetics; D003315:Cornea / Q000648:ultrastructure*; D003318:Corneal Opacity / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D005260:Female; D016368:Frameshift Mutation; D006801:Humans; D015948:Keratoplasty, Penetrating
chemical_list: D016632:Apolipoprotein A-I