title: Comparison of computed radiography and multi-detector computed tomography in the detection of post mortem metacarpal index.
abstract: BACKGROUND
  The sudden, unexpected death of young persons from ruptured thoracic aortic dissection is suggestive of Marfan syndrome (MFS), a genetic disorder of fibrillin. Establishing such a diagnosis is important so that the same fate might be avoided in living relatives. MFS diagnosis is difficult in the deceased but the presence of arachnodactyly, a common morphological feature of MFS, can be established by assessing the metacarpal index (MCI). MCI is routinely determined using radiographic techniques including computed radiography (CR). The wider availability of computed tomography (CT) in the forensic environment provides an alternative method. CT is predicted to produce measurements at least as accurate as CR. The aims of this study therefore were to (1) validate MCI measurements by comparing CT and CR with direct measurement using calipers on human skeletonised hands, and (2) compare cadaveric CT and CR MCI measurements.
  
  
  METHODS
  The metacarpals of 12 human skeleton hands were measured using CT and CR, and compared with direct measurement using calipers (the "gold standard"). Fifty randomly selected cadavers between 20 and 40 years had the MCI of both hands measured using CT and CR.
  
  
  RESULTS
  CT was found to be more accurate in the measurement of MCI than CR. There were significant differences in the MCIs obtained for CT and CR (females: p=0.01; males: p<0.0001) and between CR and calipers (p=0.004). There were no significant differences between MCIs obtained for CT and calipers (p=0.71). CR was found to consistently overestimate the MCI by an average of 7.97%.
  
  
  CONCLUSIONS
  CT is more accurate in determination of the MCI than CR and should provide the basis for future skeletal measurements.
authors: Department of Medical Imaging & Radiation Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Clayton, 3800 Victoria, Australia.
authors: Aoife
authors: A
authors: Reid
authors: Michal Elisabeth
authors: ME
authors: Schneider-Kolsky
authors: Christopher James
authors: CJ
authors: O'Donnell
mesh_terms: D000328:Adult; D054119:Arachnodactyly / Q000000981:diagnostic imaging; D002102:Cadaver; D003645:Death, Sudden / Q000209:etiology; D049429:Forensic Pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008382:Marfan Syndrome / Q000175:diagnosis; D050279:Metacarpal Bones / Q000000981:diagnostic imaging*; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed / Q000379:methods*