Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt's lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region.
We studied a group of 54 children with Burkitt's lymphoma from Southeastern Brazil, where epidemiological status of Burkitt's lymphoma is poorly understood. Epstein-Barr virus association showed an intermediate frequency (~60%) between endemic and sporadic subtypes. Median age was five years. Epstein-Barr virus infection was significantly associated to low age (Epstein-Barr virus(+) four years vs. Epstein-Barr virus(-) eight years). Sex ratio (M:F) was 2:1, with a significantly higher number of males in old age classes. Young age at diagnosis and excess of males at older ages, as well as a causal relationship between low age, epstein-barr virus and Burkitt's lymphoma risk, may characterize Burkitt's lymphoma in Brazil.
Hassan
Rocio
R
Instituto Nacional de Câncer, INCA-Bone Marrow Transplantation Centre (CEMO). Praça da Cruz Vermelha 23, 6th floor, 20230-130, Rio de Janeiro, RJ, Brazil. biomol@inca.gov.br
Klumb
Claudete Esteves
CE
Felisbino
Fabricio E
FE
Guiretti
Deisy M
DM
White
Lídia R
LR
Stefanoff
Claudio Gustavo
CG
Barros
Mario Henrique M
MH
Seuánez
Héctor N
HN
Zalcberg
Ilana R
IR
D000293:Adolescent; D001938:Brazil; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012306:Risk