title: Respiratory system determinants of peripheral fatigue and endurance performance.
abstract: We briefly summarize recent evidence pertaining to how mechanisms primarily under the control of the respiratory system-namely, arterial oxyhemoglobin desaturation, respiratory muscle work and fatigue, and cyclical fluctuations in intrathoracic pressure-may contribute to exercise limitation. Respiratory influences on cardiac output and on sympathetic vasoconstrictor activity and blood flow distribution are shown to be important determinants of performance. We also address how a compromised O2 transport exacerbates the rate of development of peripheral muscle fatigue and, in turn, precipitates central fatigue and exercise limitation.
authors: John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA. jdempsey@wisc.edu
authors: Jerome A
authors: JA
authors: Dempsey
authors: Markus
authors: M
authors: Amann
authors: Lee M
authors: LM
authors: Romer
authors: Jordan D
authors: JD
authors: Miller
mesh_terms: D001158:Arteries; D005080:Exercise Test; D005221:Fatigue / Q000378:metabolism*; D006801:Humans; D010101:Oxygen Consumption / Q000502:physiology; D010108:Oxyhemoglobins / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology; D012132:Respiratory Muscles; D012143:Respiratory Physiological Phenomena; D014481:United States
chemical_list: D010108:Oxyhemoglobins