Central diabetes insipidus following digestion Solanum indicum L. concentrated solution.
In Taiwan, Solanum indicum L. has been used in folk medicine for the treatment of inflammation, toothache, ascites, edema, and wound infection. The plant is rich in solanine, an alkaloidal glycoside. We report a 43-year-old man who developed polyuria and polydipsia after taking seven doses of concentrated solution of Solanum indicum L. over two weeks. A water deprivation test and a low serum antidiuretic hormone level helped to confirm a diagnosis of central diabetes insipidus. We suggest that excessive doses of Solanum indicum L. may cause central diabetes insipidus.
Huang
Wen-Hung
WH
Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Hsu
Ching-Wei
CW
Fang
Ji-Tseng
JT
D000328:Adult; D050034:Antidiuretic Agents / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000506:poisoning*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000506:poisoning; D011141:Polyuria / Q000139:chemically induced / Q000503:physiopathology; D012991:Solanaceous Alkaloids / Q000506:poisoning*; D012992:Solanine / Q000506:poisoning; D032322:Solanum / Q000737:chemistry*; D013624:Taiwan; D013894:Thirst / Q000187:drug effects
D050034:Antidiuretic Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012991:Solanaceous Alkaloids; D012992:Solanine; D003894:Deamino Arginine Vasopressin