Disrupting proteins to treat cancer.
Multiprotein complexes figure prominently in all cellular processes. Disrupting formation of these complexes can modulate key cellular pathways and offers new possibilities for therapeutic intervention. A new study illustrates an efficient approach for developing high-affinity mimics that inhibit protein-protein interactions.
Loh
Stewart N
SN
Department of Biochemistry and Molecular Biology, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA. lohs@upstate.edu
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D011506:Proteins