title: Functional efficacy of glatiramer acetate treatment for laser-induced retinal damage in rats.
abstract: OBJECTIVE
  To functionally evaluate the efficacy of glatiramer acetate (Cop-1) as a neuroprotective treatment for laser-induced retinal injuries in rats.
  
  
  METHODS
  Using standard lasering and flash ERG techniques, we evaluated the effect of photocoagulation and of Cop-1 treatment on retinal function 3, 20, and 60 days after covering one-half of the retina with of 23 rats with argon laser lesions.
  
  
  RESULTS
  Significant neuroprotective effects of Cop-1 treatment on functional recovery were observed 20 and 60 days after retinal photocoagulation. Two months post-lasering, the amplitude of electroretinographic signals in lasered eyes (mean+/-SEM) was 99.5+/-10.2% of that of intact eyes in the Cop-1-treated group and 85.8+/-5.5% in the untreated lasered control group (P<0.05).
  
  
  CONCLUSIONS
  Cop-1 immunization in rats is neuroprotective against laser-induced injuries to the outer retina and improves functional recovery of the injured retina. Studies have documented effective neuroprotective treatment after laser damage to myelinated neurons, but this is the first report of neuroprotection of nonmyelinated neurons.
authors: Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, 52621 Tel HaShomer, Israel.
authors: Mark
authors: M
authors: Belokopytov
authors: Gil
authors: G
authors: Ben-Shlomo
authors: Mordechai
authors: M
authors: Rosner
authors: Michael
authors: M
authors: Belkin
authors: Galina
authors: G
authors: Dubinski
authors: Yoram
authors: Y
authors: Epstein
authors: Ron
authors: R
authors: Ofri
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D004596:Electroretinography; D005126:Eye Burns / Q000209:etiology* / Q000517:prevention & control*; D000068717:Glatiramer Acetate; D017075:Laser Coagulation / Q000009:adverse effects*; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D011292:Premedication; D051381:Rats; D012160:Retina / Q000293:injuries* / Q000503:physiopathology
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D000068717:Glatiramer Acetate