Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.
Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.
Broberg
Brian Villumsen
BV
Department of Psychopharmacology, H. Lundbeck A/S, Ottiliavej 9, Valby, Denmark. bbs@lundbeck.com
Dias
Rebecca
R
Glenthøj
Birte Yding
BY
Olsen
Christina Kurre
CK
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001288:Attention / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D005260:Female; D008297:Male; D009812:Odorants; D010622:Phencyclidine; D011247:Pregnancy; D051381:Rats; D012559:Schizophrenia / Q000139:chemically induced* / Q000503:physiopathology*; D012737:Sex Factors
D010622:Phencyclidine