[Neurotransmission mechanism of movement disorders in multiple sclerosis].
A significant elevation of blood levels of exciting amino acids aspartate and glutamate as well as taurine was found. There was a strong association between the levels of these mediator amino acids and neurological deficit severity, progressive course of the disease and predominant damage of supraspinal and spinal descending motor systems. The data obtained suggest an important role of excitotoxicity in the mechanisms of autoimmune demyelinisation and development of progressive neurodegenerative changes. The results of the study emphasize the significance of neurotransmitters in development of motor functions, first of all spastic paresis. In this connection, the normalization of functional activity of neurotransmitter systems involved in the nerve tissue damage and responsible, along with immunomodulation and activation of remyelination, for motor behavior is considered as an important approach to multiple sclerosis treatment and reduction of disability caused by the disease progression.
Barkhatova
V P
VP
Panteleeva
E A
EA
Alferova
V P
VP
Rebrova
O Iu
OIu
Niiazbekova
A S
AS
Zavalishin
I A
IA
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009069:Movement Disorders / Q000378:metabolism* / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000502:physiology*; D012720:Severity of Illness Index; D009435:Synaptic Transmission / Q000502:physiology*
D001224:Aspartic Acid; D018698:Glutamic Acid