Recurrent transient global amnesia with intrathecal baclofen.
A middle-aged woman began experiencing spells of profound anterograde amnesia several months after beginning intrathecal baclofen treatment for generalized dystonia. Her spells met criteria for transient global amnesia, but were unusual because of their frequent recurrence and because their frequency was somewhat dose-dependent on baclofen. Fludrocortisone decreased the frequency of these episodes, and sublingual nitroglycerin both prevented and terminated them. Baclofen-induced amnesia in rodents is a reliable model of memory impairment. In contrast, baclofen-induced memory impairment in humans is uncommon. Baclofen- associated transient global amnesia has not previously been reported.
Grande
Lucinda A
LA
Department of Anesthesiology, Box 356540, University of Washington School of Medicine, Seattle, WA 98195, USA. cgrande@u.washington.edu
Loeser
John D
JD
Samii
Ali
A
D020324:Amnesia, Anterograde / Q000139:chemically induced*; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007278:Injections, Spinal; D007548:Isosorbide Dinitrate / Q000009:adverse effects / Q000627:therapeutic use; D007700:Kinetics; D008569:Memory Disorders / Q000139:chemically induced; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use
D009125:Muscle Relaxants, Central; D014665:Vasodilator Agents; D001418:Baclofen; D007548:Isosorbide Dinitrate