Tibolone: the way to beat many a postmenopausal ailments.
OBJECTIVE
The effects of tibolone on climacteric symptoms, osteoporosis, cardiovascular disease, breasts and the endometrium are summarised, and its role in clinical practice is reviewed in this article.


BACKGROUND
Tibolone has tissue-specific effects on receptors and enzymes that influence the synthesis and metabolism of endogenous sexual steroid hormones.


METHODS
This evaluation was based on the findings from several randomised studies, which addressed the basic and clinical research on tibolone.


CONCLUSIONS
Clinical trials prove that tibolone is effective in the treatment of the menopausal symptoms and for the postponement and calming of symptoms accompanying age-related diseases. The findings of basic researchers that tibolone affects the metabolism of every cell, including malignant cells, opened a door to a whole new domain of research that has a promising future.
Lazovic
Gordana
G
Institute of Gynecology and Obstetrics of the Clinical Centre of Serbia, 11000 Belgrade, Serbia and Montenegro. lazovicg@eunet.yu
Radivojevic
Ubavka
U
Marinkovic
Jelena
J
D001943:Breast Neoplasms / Q000139:chemically induced; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002979:Climacteric / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects / Q000503:physiopathology; D020847:Estrogen Receptor Modulators / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000502:physiology; D009652:Norpregnenes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000517:prevention & control; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020521:Stroke / Q000139:chemically induced
D020847:Estrogen Receptor Modulators; D004967:Estrogens; D009652:Norpregnenes; C027385:tibolone