title: Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems.
abstract: To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.
authors: College of Pharmacy, Yeungnam University, Kyungsan, Kyungbuk, South Korea.
authors: Madhuri
authors: M
authors: Newa
authors: Krishna Hari
authors: KH
authors: Bhandari
authors: Jong Oh
authors: JO
authors: Kim
authors: Jong Seob
authors: JS
authors: Im
authors: Jung Ae
authors: JA
authors: Kim
authors: Bong Kyu
authors: BK
authors: Yoo
authors: Jong Soo
authors: JS
authors: Woo
authors: Han Gon
authors: HG
authors: Choi
authors: Chul Soon
authors: CS
authors: Yong
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013501:Surface-Active Agents
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D007052:Ibuprofen