The effect of age and dose number on the risk of collapse (hypotonic-hyporesponsive episode) after pertussis vaccination.
The Netherlands vaccination schedule has been advanced by 1 month. The reporting rate of collapse or hypotonic-hyporesponsive episode increased from 5.2 [95% confidence interval (CI): 4.8-5.7] to 8.5 (95% CI: 8.0-9.1) and from 1.2 (95% CI: 1.0-1.4) to 2.5 (95% CI: 2.2-2.8) per 10,000 first and second doses, respectively. At 3 months of age it fell from 5.2 to 2.5. This suggests some protection by the first dose. Different mediators in primary and secondary immune response may play a role.
Vermeer-de Bondt
Patricia E
PE
Safety Surveillance and Consultation Service of the National Vaccination Programme-RIVM, Bilthoven, The Netherlands. patricia.vermeer@rivm.nl
van der Maas
Nicoline A T
NA
D000367:Age Factors; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009426:Netherlands; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D013575:Syncope; D014611:Vaccination / Q000009:adverse effects*; D014917:Whooping Cough / Q000517:prevention & control
D010567:Pertussis Vaccine