Antiepileptic ceramides from the Red Sea sponge Negombata corticata.
A new antiepileptic ceramide mixture 1 was isolated from the Red Sea sponge Negombata corticata. The structures of the metabolites were determined by extensive spectroscopic analysis. The anticonvulsant activity of 1 was measured in vivo using the pentylenetetrazole-induced seizure model. This finding has important implications for biological studies with this class of compounds.
Ahmed
Safwat A
SA
Departments of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Safwat_aa@yahoo.com
Khalifa
Sherief I
SI
Hamann
Mark T
MT
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019156:Indian Ocean; D008297:Male; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D051381:Rats
D000927:Anticonvulsants; D002518:Ceramides