Antidiabetic properties of aqueous barks extract of Parinari excelsa in alloxan-induced diabetic rats.
The aqueous extract of the Parinari excelsa barks at doses of 100 and 300 mg/kg/day for 7 days has a significant antihyperglycemic effect on alloxan-induced diabetic rats. At the same dose the acute oral administration of aqueous extract of the P. excelsa barks (100 and 300 mg/kg) induced a significant decrease of blood glucose on glucose-loaded normoglycaemic rats. Our results seem to confirm the rational bases for its use in traditional medicine.
Ndiaye
M
M
Laboratoire de Pharmacologie, Faculté de Médecine, de Pharmacie et d'Odontostomatologie, Université Cheikh Anta Diop, Dakar, Senegal. mndiaye10@sentoo.sn
Diatta
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Sy
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Dièye
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Faye
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Bassène
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D000496:Alloxan; D000818:Animals; D045469:Chrysobalanaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D005905:Glyburide