[Fatty acid composition of the blood serum and erythrocyte membrane lipids in patients with hypothyroidism and left ventricular diastolic dysfunction].
Fatty acid composition in blood serum and erythrocyte membrane lipids was studied in 38 patients with hypothyroidism treated in the Department of Endocrinology of Chita Regional Clinical Hospital; left ventricular diastolic dysfunction was revealed in 16 patients. The total content of saturated fatty acids (FA) in serum, mostly at the account of myristic and palmitic acids, was found to be increased. The total content of unsaturated FA was decreased. The level of arachidonate in blood serum and erythrocyte membrane lipids was found to be significantly decreased both before the treatment and within the course of replacing hormonal therapy. The content of omega-3 FA in erythrocyte membrane lipids decreased in the course of conventional therapy, which suggests that omega-3 FA preparations should be administered as a part of complex therapy of hypothyroidism.
Serebriakova
O V
OV
Govorin
A V
AV
Prosianik
V I
VI
Baksheeva
E V
EV
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003971:Diastole; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000150:complications; D008055:Lipids / Q000097:blood*; D009200:Myocardial Contraction / Q000502:physiology*; D011379:Prognosis; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications / Q000503:physiopathology
D015415:Biomarkers; D005227:Fatty Acids; D008055:Lipids