A convenient preparation of 5-iodo-1,4-disubstituted-1,2,3-triazole: multicomponent one-pot reaction of azide and alkyne mediated by CuI-NBS.
The system of CuI and NBS was found to provide both I (+) and Cu (+) for the first time. An efficient method for preparation of 5-iodo-1,4-disubstituted-1,2,3-triazole was achieved by multicomponent one-pot reaction of azides with alkynes in the presence of the novel CuI and NBS catalytic system. The high tolerance of various sensitive groups revealed the potential applications of this method in organic synthesis and drug discovery.
Li
Lingjun
L
College of Chemistry and Environmental Science, Henan Normal University, XinXiang 453007, P. R. China.
Zhang
Guisheng
G
Zhu
Anlian
A
Zhang
Lihe
L
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D001393:Azoles; D001557:Benzenesulfonates; D007211:Indoles; D007454:Iodides; D017672:Nitrogen Compounds; D003300:Copper; C073870:cuprous iodide