title: Panel construction for mapping in admixed populations via expected mutual information.
abstract: Mapping by admixture linkage disequilibrium (MALD) is an economical and powerful approach for the identification of genomic regions harboring disease susceptibility genes in recently admixed populations. We develop an information-theory-based measure, called expected mutual information (EMI), which computes the impact of a set of markers on the ability to infer ancestry at each chromosomal location. We then present a simple and effective algorithm for the selection of panels that strives to maximize the EMI score. Finally, we demonstrate via well-established simulation tools that our panels provide more power and accuracy for inferring disease gene loci via the MALD method in comparison to previous methods.
authors: Computer Science Department, Technion, Haifa 32000, Israel. sberco@cs.technion.ac.il
authors: Sivan
authors: S
authors: Bercovici
authors: Dan
authors: D
authors: Geiger
authors: Liran
authors: L
authors: Shlush
authors: Karl
authors: K
authors: Skorecki
authors: Alan
authors: A
authors: Templeton
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D005006:Ethnicity / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population / Q000379:methods*; D023281:Genomics / Q000379:methods; D006801:Humans; D007257:Information Theory; D015810:Linkage Disequilibrium
chemical_list: D005819:Genetic Markers