[Complex morphological approach to assessment of protective properties of preparations for cholera specific prophylaxis].
Using developed scheme, complex study of protective properties of avirulent recombinant strain Vibrio cholerae El Tor Inaba KM 184 was performed. Necessity for broadening of standard procedure of testing of cholera vaccines protective properties by using of quantitative methods of assessment of morphological changes and state of biomodel's functional systems, which could increase the information value of assessment of studied vaccines, was experimentally substantiated.
Bugorkova
S A
SA
Zadumina
S Iu
SIu
Bugorkova
T V
TV
Lotsmanova
E Iu
EIu
Kravtsov
A L
AL
Shchukovskaia
T N
TN
Kutyrev
V V
VV
D000284:Administration, Oral; D000818:Animals; D002771:Cholera / Q000503:physiopathology* / Q000517:prevention & control*; D002772:Cholera Toxin / Q000096:biosynthesis / Q000235:genetics; D022121:Cholera Vaccines / Q000008:administration & dosage*; D005069:Evaluation Studies as Topic; D010446:Peptide Fragments / Q000096:biosynthesis / Q000235:genetics; D011817:Rabbits; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D041241:Vibrio cholerae O1 / Q000276:immunology* / Q000378:metabolism; D014781:Viscera / Q000503:physiopathology
D022121:Cholera Vaccines; D010446:Peptide Fragments; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; C050310:cholera toxin, B subunit (50-64); D002772:Cholera Toxin