title: PICOT: a multidomain scaffolding inhibitor of hypertrophic signal transduction.
authors: Allen M
authors: AM
authors: Samarel
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D001667:Binding, Competitive; D019703:Calcineurin / Q000378:metabolism*; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D048429:Cell Size; D060588:LIM Domain Proteins; D040542:Mechanotransduction, Cellular; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D050778:NFATC Transcription Factors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010656:Phenylephrine / Q000494:pharmacology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017434:Protein Structure, Tertiary; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013879:Thioredoxins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D060588:LIM Domain Proteins; D009124:Muscle Proteins; D050778:NFATC Transcription Factors; D009419:Nerve Tissue Proteins; C477593:Nfatc4 protein, rat; D011993:Recombinant Fusion Proteins; C090114:cysteine and glycine-rich protein 3; D010656:Phenylephrine; D013879:Thioredoxins; C120817:calcineurin phosphatase; D019703:Calcineurin; D010744:Phosphoric Monoester Hydrolases