title: Integrating research into routine service delivery in an antiretroviral treatment programme: lessons learnt from a cluster randomized trial comparing strategies of HIV care in Jinja, Uganda.
abstract: Trials integrated into normal health service delivery are designed to evaluate the effectiveness of interventions under real-life conditions. However, integrating research into service delivery creates many operational challenges and raises ethical dilemmas. Here we discuss the operational and ethical issues arising from such trials using the example of a cluster randomized trial evaluating two strategies of ART delivery in Jinja, south-east Uganda.
authors: Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. shabbar.jaffar@lshtm.ac.uk
authors: Shabbar
authors: S
authors: Jaffar
authors: Barbara
authors: B
authors: Amuron
authors: Josephine
authors: J
authors: Birungi
authors: Geoffrey
authors: G
authors: Namara
authors: Christine
authors: C
authors: Nabiryo
authors: Alex
authors: A
authors: Coutinho
authors: Heiner
authors: H
authors: Grosskurth
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D035843:Biomedical Research; D003695:Delivery of Health Care / Q000458:organization & administration*; D004059:Diffusion of Innovation; D032984:Ethics, Research; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000941:ethics; D012107:Research Design; D014454:Uganda; D016526:Workload
chemical_list: D019380:Anti-HIV Agents