title: Cytoplasmic dynein could be key to understanding neurodegeneration.
abstract: A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase.
authors: Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK. g.banks@prion.ucl.ac.uk.
authors: Gareth T
authors: GT
authors: Banks
authors: Elizabeth M C
authors: EM
authors: Fisher
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics; D000818:Animals; D003593:Cytoplasm / Q000201:enzymology; D056445:Cytoplasmic Dyneins; D004398:Dyneins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000235:genetics*; D009475:Neurons, Afferent / Q000502:physiology
chemical_list: C516947:Dync1h1 protein, mouse; D056445:Cytoplasmic Dyneins; D004398:Dyneins