[Synthesis of polyamine-containing oligonucleotides].
A simple and efficient method of synthesis of polyamine-oligonucleotide conjugates in high yields (up to 95%) was suggested. The terminal phosphate group of deprotected oligonucleotides was selectively activated with the redox pair triphenylphosphine-dipyridyl disulfide in the presence of a nucleophilic catalyst, and the activated oligonucleotide derivative was subjected to the reaction with a polyamine.
Levina
A S
AS
Mikhaleva
E A
EA
Repkova
M N
MN
Zarytova
V F
VF
D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry
D009841:Oligonucleotides; D011073:Polyamines