Association between GERD-related erosive esophagitis and obesity.
OBJECTIVE
To date, many studies have reported on the association of obesity with gastroesophageal reflux disease (GERD), although none of these have been systematic. In light of this, we conducted this study to examine the association of obesity and GERD.


METHODS
A total of 3363 patients underwent gastroscopy at Hanyang University Health Promotion Center. Among these patients, we prospectively examined patients who were diagnosed with GERD-related erosive esophagitis on endoscopy.


RESULTS
Multivariate analysis showed that the significant risk factors were waist-to-hip ratio (WHR), hiatal hernia, body mass index (BMI), and smoking. As compared with patients who had a WHR less than 0.8, the multivariate odds ratio for erosive esophagitis were 4.055 for a WHR more than 1.0 and 2.316 for a WHR of 0.8 to 1.0. As compared with patients who had a BMI of 20 to 22.5, the multivariate odds ratio for erosive esophagitis was 3.308 (95% confidence interval, 1.792 to 6.107) for a BMI greater than 30.


CONCLUSIONS
Obesity, especially abdominal obesity, was the significant risk factor for erosive esophagitis.
Lee
Hang Lak
HL
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. alwayshang@hanyang.ac.kr
Eun
Chang Soo
CS
Lee
Oh Young
OY
Jeon
Yong Cheol
YC
Sohn
Ju Hyun
JH
Han
Dong Soo
DS
Yoon
Byung Chul
BC
Choi
Ho Soon
HS
Hahm
Joon Soo
JS
Lee
Min Ho
MH
Lee
Dong Hoo
DH
D050153:Abdominal Fat; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D004941:Esophagitis / Q000453:epidemiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000503:physiopathology; D005773:Gastroscopy; D006551:Hernia, Hiatal / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D049629:Waist-Hip Ratio / Q000009:adverse effects