Neural stem cells: balancing self-renewal with differentiation.
Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation and have revealed the proteins, processes and pathways that all converge to regulate neural progenitor self-renewal. If we can better understand how stem cells balance self-renewal versus differentiation, we will significantly advance our knowledge of embryogenesis, cancer biology and brain evolution, as well as the use of stem cells for therapeutic purposes.
Doe
Chris Q
CQ
Howard Hughes Medical Institute, Institute of Neuroscience, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA. cdoe@uoregon.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D004330:Drosophila / Q000166:cytology / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D007605:Juvenile Hormones / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology
D029721:Drosophila Proteins; D007605:Juvenile Hormones; C060606:numb protein, Drosophila