Distribution and excretion of BisGMA in guinea pigs.
Bisphenol-A-glycidyldimethacrylate (BisGMA) is used in many resin-based dental materials. It was shown in vitro that BisGMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of [(14)C]BisGMA applied via gastric and intravenous administration (at dose levels well above those encountered in dental care) were examined in vivo in guinea pigs to test the hypothesis that BisGMA reaches cytotoxic levels in mammalian tissues. [(14)C]BisGMA was taken up rapidly from the stomach and intestine after gastric administration and was widely distributed in the body following administration by each route. Most [(14)C] was excreted within one day as (14)CO(2). The peak equivalent BisGMA levels in guinea pig tissues examined were at least 1000-fold less than known toxic levels. The peak urine level in guinea pigs that received well in excess of the body-weight-adjusted dose expected in humans was also below known toxic levels. The study therefore did not support the hypothesis.
Reichl
F X
FX
Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, Ludwig-Maximilians-University of Munich, Goethestr. 70, 80336 Munich, Germany. reichl@lmu.de
Seiss
M
M
Kleinsasser
N
N
Kehe
K
K
Kunzelmann
K H
KH
Thomas
P
P
Spahl
W
W
Hickel
R
R
D000818:Animals; D001646:Bile / Q000737:chemistry; D017438:Bisphenol A-Glycidyl Methacrylate / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D001769:Blood; D002245:Carbon Dioxide / Q000032:analysis; D002250:Carbon Radioisotopes; D003549:Cystic Duct; D003764:Dental Materials / Q000032:analysis / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007322:Instillation, Drug; D007601:Jugular Veins; D008297:Male; D019275:Radiopharmaceuticals; D011897:Random Allocation; D013997:Time Factors; D014018:Tissue Distribution; D014556:Urine
D002250:Carbon Radioisotopes; D003764:Dental Materials; D019275:Radiopharmaceuticals; D002245:Carbon Dioxide; D017438:Bisphenol A-Glycidyl Methacrylate