[Fibrin-based biomaterials for medical device].
OBJECTIVE
To broaden the clinical uses of fibrin-based biomaterials and to develop further study in cell biology and to comprehensively understand and master related knowledge with regard to the present development status of fibrin.


METHODS
Many relevant domestic and international papers were reviewed to make a summary.


RESULTS
Recognization was obtained from four aspects, which were structure and function of fibrinogen, clinical use of fibrin, fibrin scaffold for tissue engineering, and compounding biomaterials of fibrin. It showed that every aspect had great research extension and practical application.


CONCLUSIONS
Besides a surgical hemostat and sealant, fibrin has great potentials in playing roles of tissue engineering scaffold, drug delivery vehicle, and compounding material.
Gu
Qisheng
Q
Shanghai Qisheng Institute of Biomaterials & Technology, Shanghai, 201106, P.R. China. qish@shqisheng.com
Wang
Jianing
J
D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D005337:Fibrin; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000737:chemistry*; D005782:Gels; D006490:Hemostatics; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D005782:Gels; D006490:Hemostatics; D005337:Fibrin; D005340:Fibrinogen