title: Closed loop control of oxgenation and ventilation.
abstract: Closed loop control of oxygenation and ventilation during mechanical ventilatory support is essential for remote medical care in an austere environment. Closed loop control allows for expert systems to provide the current standard of care in the absence of on-site expertise. Ventilation may be controlled by simple systems incorporating patient height or by advanced systems incorporating measurements of end-tidal carbon dioxide (ETCO2) and pulmonary impedance. Oxygenation may be controlled by adjustments of inspired oxygen concentrations (FIO2) and positive end-expiratory pressure (PEEP) using pulse oximetry (SpO2) as the input. Control of oxygenation can prevent hypoxemia and has the potential to reduce oxygen requirements. A double closed loop system of oxygenation control including control of FIO2 via SpO2 and control of oxygen generation by a portable oxygen generator (POG) based on FIO2 and minute ventilation (VE) promises safety and efficiency. Remote control of ventilation and oxygenation is possible using existing technology.
authors: University of Cincinnati, Dept. of Surgery, 231Albert Sabin Way, Cincinnati, OH 45267-0558, USA. jay.johannigman@uc.edu
authors: Jay
authors: J
authors: Johannigman
authors: Richard D
authors: RD
authors: Branson
authors: Peter
authors: P
authors: Muskat
authors: Stephen L
authors: SL
authors: Barnes
authors: George
authors: G
authors: Beck
mesh_terms: D000328:Adult; D004867:Equipment Design; D005103:Expert Systems; D006801:Humans; D008887:Military Medicine; D010100:Oxygen / Q000378:metabolism*; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D019114:Remote Consultation; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods*; D015656:Respiratory Mechanics; D013026:Space Flight; D018511:Systems Integration; D013990:Tidal Volume; D014939:Work of Breathing; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*
chemical_list: D010100:Oxygen