Association study of TP53 polymorphisms with lung cancer in a Korean population.
The tumor suppressor gene, TP53, is located on chromosome 17p13.1 and is critical for DNA repair, cell-cycle control, and apoptosis. TP53 also plays a crucial function in the tumorigenesis of lung cancer. Inactivation of TP53 via genetic alterations such as missense mutations is often associated with lung cancer. In this study, potential association of TP53 polymorphisms with the risk of lung cancer was examined in a Korean population. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed, and logistic regression analyses were conducted to characterize the association between TP53 polymorphisms and lung cancer risk. Through direct sequencing in 24 Korean individuals, 13 sequence variants were identified, and five of these polymorphisms were selected for a larger-scale genotyping (n = 595). Statistical analyses revealed that polymorphisms and haplotypes in the TP53 gene, including Arg72Pro, were not significantly associated with lung cancer in a Korean population.
Jung
Hae-Yun
HY
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Whang
Young Mi
YM
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Sung
Jae Sook
JS
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Shin
Hyoung Doo
HD
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.|Department of Genetic Epidemiology, SNP Genetics, Inc, Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, Gasan-Dong, Geumcheon-Gu, Seoul, 371-28, South Korea.
Park
Byung Lae
BL
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.|Department of Genetic Epidemiology, SNP Genetics, Inc, Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, Gasan-Dong, Geumcheon-Gu, Seoul, 371-28, South Korea.
Kim
Jun Suk
JS
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Shin
Sang Won
SW
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Seo
Hee Yun
HY
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Seo
Jae Hong
JH
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
Kim
Yeul Hong
YH
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea. yhk0215@korea.ac.kr.
D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016158:Genes, p53; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D004273:DNA, Neoplasm