title: Treatment of pruritic diseases with topical calcineurin inhibitors.
abstract: The introduction of topical calcineurin inhibitors resulted in a significant improvement in the treatment of atopic dermatitis. In addition, rapid amelioration of pruritus could be observed. In case reports, other pruritic dermatoses such as chronic irritative hand dermatitis, rosacea, graft-versus-host-disease, and lichen sclerosus were also treated successfully with pimecrolimus and tacrolimus. Twenty patients were treated with tacrolimus and pimecrolimus in a surveillance study to evaluate efficacy in pruritus and prurigo. Eighteen of 20 patients responded to therapy. Best results were obtained in localized and generalized pruritus while in prurigo nodularis only a subgroup of patients showed an improvement of pruritus. Further controlled studies are necessary to confirm these results.
authors: Clinical Neurodermatology, Department of Dermatology, University Hospital Münster Germany.
authors: Sonja
authors: S
authors: Ständer
authors: Funda
authors: F
authors: Schürmeyer-Horst
authors: Thomas A
authors: TA
authors: Luger
authors: Elke
authors: E
authors: Weisshaar