title: Time-dependent ventilatory response to poikilocapnic hypoxia during light and dark periods and the role of histamine H1 receptors in mice.
abstract: We tested the hypothesis that the biphasic ventilatory response to poikilocapnic hypoxia shows circadian variation and contribution of histamine H1 receptors in mice. Initial increases in ventilation were augmented during dark periods. H1 receptors had no major relationship with circadian variation, but affected the declined phase.
authors: Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan.
authors: Yasuyoshi
authors: Y
authors: Ohshima
authors: Michiko
authors: M
authors: Iwase
authors: Masahiko
authors: M
authors: Izumizaki
authors: Mitsuko
authors: M
authors: Kanamaru
authors: Ikuo
authors: I
authors: Homma
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010100:Oxygen / Q000378:metabolism; D017440:Photoperiod; D012123:Pulmonary Ventilation / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000235:genetics / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D013997:Time Factors
chemical_list: D011969:Receptors, Histamine H1; D002245:Carbon Dioxide; D010100:Oxygen