title: Association study of serotonin system genes in childhood-onset mood disorder.
abstract: BACKGROUND
  The serotonin system has been implicated in neuropsychiatric disorders, including mood disorders.
  
  
  METHODS
  We investigated polymorphisms in two serotonin-receptor genes, HTR1B and HTR2A, and the serotonin transporter (SLC6A4) in two independent samples of patients with childhood-onset mood disorders (COMD): 203 patients from Pittsburgh, USA with matched controls and 448 small families from Hungary.
  
  
  RESULTS
  Case-control and family-based analyses showed no association between COMD and any of the studied polymorphisms (all P values >0.05). Haplotype analysis of SLC6A4 was also negative in both samples.
  
  
  CONCLUSIONS
  Overall, the examination of genetic variants at the HTR1B, HTR2A, and SLC6A4 loci indicated no association between the selected polymorphisms and COMD.
authors: Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.
authors: Sajid A
authors: SA
authors: Shaikh
authors: John
authors: J
authors: Strauss
authors: Nicole
authors: N
authors: King
authors: Natalie L
authors: NL
authors: Bulgin
authors: Agnes
authors: A
authors: Vetró
authors: Enikö
authors: E
authors: Kiss
authors: Charles J
authors: CJ
authors: George
authors: Maria
authors: M
authors: Kovacs
authors: Cathy L
authors: CL
authors: Barr
authors: James L
authors: JL
authors: Kennedy
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D003866:Depressive Disorder / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D010290:Parents; D010414:Pennsylvania / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics* / Q000502:physiology; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D035781:Siblings
chemical_list: C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin