[Protective effects of Hongbeiyegen against immunological liver injury in mice].
OBJECTIVE
To investigate the protective effects of Hongbeiyegen (HBYG) against immunological liver injury induced by bacille Calmette-Guerin (BCG) and lipopolysaccharide (LPS).


METHODS
Immunological liver injury was induced in rats by BCG and LPS injected via the tail vein. The liver index, thymus index and spleen index were calculated and the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and nitric oxide (NO) and liver homogenate contents of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were determined.


RESULTS
HBYG significantly improved the liver index, thymus index and spleen index, and reduced the serum levels of ALT, AST and NO, and as the liver homogenate contents of TNF-alpha and IL-1beta.


CONCLUSIONS
HBYG offers obvious protective effects against immunological injury liver in mice.
Song
Yu-hong
YH
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. songyuhong645@ hotmail.com
Liu
Qiang
Q
Chen
Yu-yao
YY
Lü
Zhi-ping
ZP
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D053583:Interleukin-1beta / Q000378:metabolism; D008070:Lipopolysaccharides; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C528815:hongbeiyegen; D009569:Nitric Oxide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase