title: Gene-environment correlation and interaction in peer effects on adolescent alcohol and tobacco use.
abstract: Peer relationships are commonly thought to be critical for adolescent socialization, including the development of negative health behaviors such as alcohol and tobacco use. The interplay between genetic liability and peer influences on the development of adolescent alcohol and tobacco use was examined using a nationally-representative sample of adolescent sibling pairs and their best friends. Genetic factors, some of them related to an adolescent's own substance use and some of them independent of use, were associated with increased exposure to best friends with heavy substance use--a gene-environment correlation. Moreover, adolescents who were genetically liable to substance use were more vulnerable to the adverse influences of their best friends--a gene-environment interaction.
authors: Department of Psychology, University of Virginia, PO Box 400400, Charlottesville, VA 22904-4400, USA. paigeharden@virginia.edu
authors: K Paige
authors: KP
authors: Harden
authors: Jennifer E
authors: JE
authors: Hill
authors: Eric
authors: E
authors: Turkheimer
authors: Robert E
authors: RE
authors: Emery
mesh_terms: D000293:Adolescent; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology*; D004777:Environment; D005260:Female; D033062:Friends; D006306:Health Surveys; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D010379:Peer Group; D000297:Psychology, Adolescent; D035781:Siblings; D012907:Smoking / Q000235:genetics* / Q000523:psychology*