Alachalasins A-G, new cytochalasins from the fungus Stachybotrys Podospora vesticola [corrected].
Alachalasins A-G (1-7), seven new cytochalasin-type of metabolites, have been isolated from cultures of an isolate of Stachybotrys Podospora vesticola [corrected] The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data, and the absolute configuration of 1 was assigned by application of the modified Mosher method. Alachalasin A (1) displayed inhibitory effect on HIV-1LAI replication in C8166 cells with an EC50 of 8.01 microM; alachalasins D (4) and G (7) showed modest antimicrobial activity.
Zhang
Yonggang
Y
Key Laboratory of Systematic Mycology and Lichenology, and Center for Bio-Energy and Industrial Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Tian
Renrong
R
Liu
Shuchun
S
Chen
Xulin
X
Liu
Xingzhong
X
Che
Yongsheng
Y
D000935:Antifungal Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology; D002460:Cell Line; D003572:Cytochalasins / Q000737:chemistry / Q000145:classification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013191:Stachybotrys / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D000998:Antiviral Agents; D003572:Cytochalasins; D006576:Heterocyclic Compounds, 4 or More Rings