title: Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging.
abstract: Specific mutations in the human gene encoding lamin A or in the lamin A-processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.
authors: Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. meshorer@cc.huji.ac.il
authors: Eran
authors: E
authors: Meshorer
authors: Yosef
authors: Y
authors: Gruenbaum
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D034882:Lamins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D011371:Progeria / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D034882:Lamins; D008565:Membrane Proteins; D051880:Receptors, Notch; D051153:Wnt Proteins; D008666:Metalloendopeptidases