Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort.
BACKGROUND
Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR.


METHODS
Type 2 diabetic patients with and without retinopathy were recruited. The -634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests.


RESULTS
No significant association was observed between genotypes, alleles and haplotypes of -634C/G and 936C/T polymorphisms and DR or its severity. However, C(-634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3).


CONCLUSIONS
Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.
Uthra
Satagopan
S
SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Raman
Rajiv
R
Mukesh
Bickol N
BN
Rajkumar
Samuel A
SA
Padmaja
Kumari R
KR
Paul
Pradeep G
PG
Lakshmipathy
Praveena
P
Gnanamoorthy
Perumal
P
Sharma
Tarun
T
McCarty
Catherine A
CA
Kumaramanickavel
Govindasamy
G
D000368:Aged; D000419:Albuminuria / Q000209:etiology; D044466:Asian People / Q000235:genetics*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000652:urine; D003930:Diabetic Retinopathy / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A