title: Preventive effect of a traditional herbal medicine, Hochu-ekki-to, on immunosuppression induced by surgical stress.
abstract: OBJECTIVE
  To examine the effect of preoperative administering of a Japanese traditional herbal medicine, Hochu-ekki-to (TJ-41), on immunosuppression induced by surgical stress in patients with gastrointestinal malignancies.
  
  
  METHODS
  To monitor the immune functions, the mitochondrial membrane potential (MMP) and natural killer (NK) cell activity prior to and following operation were measured in peripheral blood lymphocytes (PBL) in patients with (n = 20) or without (n = 27) the preoperative administering of TJ-41 for 7 days. The plasma catecholamine and interleukin (IL)-6 levels were also analyzed prior to and following the operation.
  
  
  RESULTS
  The numbers of MMP-high CD56-positive cells (NK cells) and NK cell activities in the TJ-41-treated group were significantly higher than those in the control group (P = 0.026 and P = 0.037, respectively). An elevation of plasma noradrenaline and IL-6 following surgery was also inhibited by the preoperative administering of TJ-41 (P = 0.023 and P = 0.039, respectively). A positive correlation between MMP-high CD56-positive cell numbers and NK cell activity in PBL treated with carbonyl cyanide m-chlorophenyl hydrazone (CCCP) in vitro suggested that MMP measurement in CD56-positive cells can serve as a convenient alternative to evaluate the NK cell activity.
  
  
  CONCLUSIONS
  Our findings suggest that the preoperative administering of TJ-41 prevents surgical stress-induced immunosuppression by maintaining the NK cell activity and inhibiting the elevation of stress mediators.
authors: Department of Surgery, Kitano Hospital, Tazuke-Kofukai Medical Research Institute, Kita-ku, Osaka 530-8480, Japan.
authors: Motohide
authors: M
authors: Kimura
authors: Tetsuro
authors: T
authors: Sasada
authors: Michiyuki
authors: M
authors: Kanai
authors: Yasuhiro
authors: Y
authors: Kawai
authors: Yuka
authors: Y
authors: Yoshida
authors: Eriko
authors: E
authors: Hayashi
authors: Shingo
authors: S
authors: Iwata
authors: Arimichi
authors: A
authors: Takabayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004334:Drug Administration Schedule; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D013312:Stress, Physiological / Q000139:chemically induced / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; C402943:bu-zhong-yi-qi-tang