Nornicotine-organocatalyzed aqueous reduction of alpha,beta-unsaturated aldehydes.
Nornicotine, a native component of tobacco and minor nicotine metabolite, was found to catalyze the chemoselective reduction of alpha,beta-unsaturated aldehydes under homogeneous aqueous conditions.
Brogan
Andrew P
AP
Department of Chemistry, Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Dickerson
Tobin J
TJ
Janda
Kim D
KD
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004121:Dimethyl Sulfoxide; D009243:NAD / Q000737:chemistry; D009538:Nicotine / Q000031:analogs & derivatives* / Q000737:chemistry; D010084:Oxidation-Reduction; D012996:Solutions; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D012996:Solutions; D014867:Water; D009243:NAD; D009538:Nicotine; C005311:nornicotine; D004121:Dimethyl Sulfoxide