title: An expedient synthesis of the fibril binding compound FSB via sequential Pd-catalyzed coupling reactions.
abstract: The styryl benzene derivative (E, E)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), well-known for its binding to beta-amyloid peptide fibrils, was synthesized in an efficient manner exploiting two sequential palladium(0)-catalyzed coupling reactions in a 34% overall yield. This is a substantial improvement to the previously reported synthesis of FSB in 1.1%.
authors: The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark.
authors: Mette Louise H
authors: ML
authors: Mantel
authors: Lina S
authors: LS
authors: Søbjerg
authors: Tri H V
authors: TH
authors: Huynh
authors: Jean-Philippe
authors: JP
authors: Ebran
authors: Anders T
authors: AT
authors: Lindhardt
authors: Niels C
authors: NC
authors: Nielsen
authors: Troels
authors: T
authors: Skrydstrup
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C496440:(E,E)-1-fluoro-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene; D013343:Styrenes; D010165:Palladium