title: Apical regional wall motion abnormalities reminiscent to Tako-Tsubo cardiomyopathy following consumption of psychoactive fungi.
abstract: Consumption of natural hallucinogenic substances continues to be a problem. In this case we report from a young male patient presenting with an acute coronary syndrome with significant ST-elevation after the abuse of psychoactive fungi, commonly referred to as "magic mushrooms". Coronary angiography excludes relevant coronary artery disease. In ventriculography contractile dysfunction with hypokinesia in the apical segments could be documented reminiscent to wall motion abnormalities in Tako-Tsubo cardiomyopathy (TTC). Cardiovascular magnetic resonance imaging showed no pathological signal activity in the late-enhancement sequences ruling out myocardial infarction or inflammatory processes. Ventricular function normalized within several days. The active metabolite of psychoactive fungi psilocybin is known to interact with several different dopaminergic, adrenergic and serotonergic receptors. Thus, the pathomechanisms leading to contractile dysfunction after consumption of psychoactive fungi are reminiscent to those documented in TTC.
authors: Holger M
authors: HM
authors: Nef
authors: Helge
authors: H
authors: Möllmann
authors: Pirmin
authors: P
authors: Hilpert
authors: Nicola
authors: N
authors: Krause
authors: Christian
authors: C
authors: Troidl
authors: Michael
authors: M
authors: Weber
authors: Andreas
authors: A
authors: Rolf
authors: Thorsten
authors: T
authors: Dill
authors: Christian
authors: C
authors: Hamm
authors: A
authors: A
authors: Elsässer
mesh_terms: D054058:Acute Coronary Syndrome / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D000293:Adolescent; D017023:Coronary Angiography; D006213:Hallucinogens / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011562:Psilocybin / Q000009:adverse effects*; D054549:Takotsubo Cardiomyopathy / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D006213:Hallucinogens; D011562:Psilocybin