Chemical modifications of AFM tips for the study of molecular recognition events.
The use of AFM to study molecular recognition events at an incredible level of sensitivity is currently a very active field of research. In order to get information at the single molecule level, it is mandatory to modify in a precise manner the AFM tip to anchor either ligand or receptor molecules. In the following lines, we review the achievements in tip modifications and illustrate the scope and limitations of the different strategies that have been reported.
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CEA-LETI, Laboratoire de Fonctionnalisation et Chimie pour les Microsystèmes, 17 rue des Martyrs, F-38054 Grenoble cedex 9, France.
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D000906:Antibodies / Q000737:chemistry; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000295:instrumentation* / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012680:Sensitivity and Specificity; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
D000906:Antibodies; D000941:Antigens; D037742:Nanotubes, Carbon; D010455:Peptides; D011092:Polyethylene Glycols; D006046:Gold; D012825:Silicon