title: Endocrine and metabolic differences among phenotypic expressions of polycystic ovary syndrome according to the 2003 Rotterdam consensus criteria.
abstract: OBJECTIVE
  The Rotterdam criteria extend the phenotypic spectrum of polycystic ovary syndrome (PCOS). We characterized endocrine and metabolic differences among women meeting the National Institutes of Health (NIH) definition for PCOS vs two novel phenotypes established by the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine definition.
  
  
  METHODS
  Endocrine and metabolic data from a retrospective analysis of 160 age- and weight-matched women with PCOS and 23 controls were compared. Insulin sensitivity indices were correlated with androgens, gonadotropins, and lipids within each phenotype.
  
  
  RESULTS
  Ovarian and adrenal androgens were highest in the NIH-defined PCOS group, lowest in the nonhyperandrogenic PCOS group, and intermediate in the hyperandrogenic ovulatory PCOS population. Insulin sensitivity indices, gonadotropins, and lipids were similar across all PCOS phenotypes. The magnitude of insulin resistance correlated with free testosterone only in the NIH-defined group.
  
  
  CONCLUSIONS
  Androgen levels are the major distinguishing endocrine feature differentiating phenotypic expressions of PCOS. Hyperinsulinemia correlates with free testosterone levels only in traditional NIH-defined women with PCOS.
authors: Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, Amarillo, TX 79106, USA. robert.kauffman@ttuhsc.edu
authors: Robert P
authors: RP
authors: Kauffman
authors: Teresa E
authors: TE
authors: Baker
authors: Vicki M
authors: VM
authors: Baker
authors: Pamela
authors: P
authors: DiMarino
authors: V Daniel
authors: VD
authors: Castracane
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D016022:Case-Control Studies; D015870:Gene Expression; D006062:Gonadotropins / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D009316:National Institutes of Health (U.S.); D009426:Netherlands; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D012189:Retrospective Studies; D013739:Testosterone / Q000097:blood; D014481:United States; D003245:Consensus Statements as Topic
chemical_list: D006062:Gonadotropins; D008055:Lipids; D013739:Testosterone