title: Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis.
abstract: The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III (3), IV (4), V (5), VI (6), and VII (7), were isolated together with four known saponins, bellidioside A (8), asterbatanoside D (9), bernardioside B 2 (10), and bellissaponin BS6 (11). The stereostructures of 1- 7 were elucidated on the basis of chemical and spectroscopic evidence. Among these saponins, perennisosides I (1) and II (2) showed inhibitory effects on serum triglyceride elevation at doses of 25-50 mg/kg, po.
authors: Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan.
authors: Toshio
authors: T
authors: Morikawa
authors: Xuezheng
authors: X
authors: Li
authors: Eriko
authors: E
authors: Nishida
authors: Yuki
authors: Y
authors: Ito
authors: Hisashi
authors: H
authors: Matsuda
authors: Seikou
authors: S
authors: Nakamura
authors: Osamu
authors: O
authors: Muraoka
authors: Masayuki
authors: M
authors: Yoshikawa
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008049:Lipase / Q000032:analysis* / Q000097:blood* / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D012503:Saponins; D014315:Triterpenes; D008049:Lipase