2B-Trans technology: targeted drug delivery across the blood-brain barrier.
Drug delivery across the blood-brain barrier (BBB) is a major obstacle for the development of effective treatments of many central nervous system disorders. Sophisticated cell culture models of the BBB have helped us to identify, characterize, and validate a novel targeted drug delivery technology, designated 2B-Trans, for the receptor-mediated uptake and transport of drugs across the BBB. This paper describes in great detail how such a BBB cell culture model should be prepared and handled, and applied for the use of targeted drug delivery across the BBB.
Gaillard
Pieter J
PJ
Bio-Science Park Leiden, Leiden, The Netherlands.
de Boer
Albertus G
AG
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain; D018920:Coculture Techniques; D016503:Drug Delivery Systems; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011955:Receptors, Drug / Q000235:genetics / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D011955:Receptors, Drug