Role of apolipoproteins E and A-I: epistatic villains of triglyceride mediation in coronary heart disease.
The epistatic effects of ApoE (HhaI) and ApoA-I (PstI) genes as the genetic modulators of lipid levels were investigated in 165 angiographically verified CHD patients and 120 controls of Punjab, a northwest province of India. It has been revealed that of all the genotypic combinations of ApoE and ApoA-I, E4 allele carriers (E4+) with P1P2 genotype (ApoA-I/PstI) had higher risk of CHD (OR 2.99, CI 1.31-6.8, P<0.01) which exacerbated (OR 3.44, CI 1.45-8.15, P<0.01) after adjustment with the confounders. Individually, neither ApoA-I nor ApoE was found to be associated with TG levels however, pairwise epistasis (additive x additive model) explored their significant synergistic contributions with raised TG levels (P<0.01).
Singh
Puneetpal
P
Singh
Monica
M
Kaur
Taranpal
T
D000368:Aged; D016632:Apolipoprotein A-I / Q000235:genetics / Q000502:physiology*; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood* / Q000235:genetics*; D004843:Epistasis, Genetic / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood* / Q000235:genetics
D016632:Apolipoprotein A-I; D001057:Apolipoproteins E; D014280:Triglycerides