Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1.
Azeotropic reflux chromatography (in which the eluent is continuously recycled by means of refluxing) was used to separate a mixture of spiroketal intermediates in the scale-up synthesis of spongistatin 1, leading to an improved separation and an approximately 35-fold reduction in the amount of solvent used.
O'Brien
Matthew
M
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW. mo263@cam.ac.uk
Diéguez-Vázquez
Alejandro
A
Hsu
Day-Shin
DS
Kraus
Helmut
H
Sumino
Yukihito
Y
Ley
Steven V
SV