title: Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration.
abstract: OBJECTIVE
  To evaluate the hepatic effect of Croton cajucara Benth (sacaca) herbal extract in rats.
  
  
  METHODS
  60 Wistar rats (Rattus novergicus albinus) were used, weighing between 250 and 350 g. The animals were distributed randomically in 2 groups: GS - animals which received daily 0,1 ml/ 100 g of sacaca herbal extract through gavage, and GA -animals which received daily 0,1 ml/100g of distilled water through gavage. These were distributed in 3 subgroups with 10 animals, according to theirs euthanasia dates, which were 14th, 28th and 56th day of treatment.
  
  
  RESULTS
  Architectural alterations were not observed, however when it was analyzed the presence or absence of necrosis, it was observed in 50% of GS28 subgroup and 90% of subgroup. In 50% of the animals from GS28 subgroup and 90% of GS56 subgroup was observed vast degeneration areas and zonal necrosis, regarding center-lobular veins alterations, there were no alterations in any of the groups
  
  
  CONCLUSIONS
  The Croton cajucara Benth (sacaca) herbal extract in this experiment caused degeneration and hepatic necrosis, suggesting dose-dependent action.
authors: Integrated Health Department, State University of Pará, Brazil. Jgraim@yahoo.com.br
authors: Jair Francisco de Santana
authors: JF
authors: Graim
authors: Gaspar de Jesus
authors: Gde J
authors: Lopes Filho
authors: Marcus Vinicius Henriques
authors: MV
authors: Brito
authors: Lia Tavares de Moura
authors: LT
authors: Brasil Matos
mesh_terms: D000818:Animals; D029802:Croton / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D010936:Plant Extracts / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D010936:Plant Extracts