The potential role of nutritional components in the management of Alzheimer's Disease.
Epidemiological evidence linking nutrition to the incidence and risk of Alzheimer Disease is rapidly increasing. The specific nutritional deficiencies in Alzheimer patients may suggest a relative shortage of specific macro- and micronutrients. These include omega-3 fatty acids, several B-vitamins and antioxidants such as vitamins E and C. Recent mechanistic studies in cell systems and animal models also support the idea that nutritional components are able to counteract specific aspects of the neurodegenerative and pathological processes in the brain. In addition, it has been shown that several nutritional components can also effectively stimulate membrane formation and synapse formation as well as improve behavior and cerebrovascular health. The suggested synergy between nutritional components to improve neuronal plasticity and function is supported by epidemiological studies as well as experimental studies in animal models. The ability of nutritional compositions to stimulate synapse formation and effectively reduce Alzheimer Disease neuropathology in these preclinical models provides a solid basis to predict potential to modify the disease process, especially during the early phases of Alzheimer Disease.
van der Beek
Eline M
EM
Numico Research, P.O.box 7005 6700 CA Wageningen, The Netherlands.
Kamphuis
Patrick J G H
PJ
D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000178:diet therapy* / Q000378:metabolism* / Q000503:physiopathology; D000975:Antioxidants / Q000008:administration & dosage; D001921:Brain / Q000503:physiopathology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000502:physiology; D006801:Humans; D044623:Nutrition Therapy; D013569:Synapses / Q000502:physiology; D014815:Vitamins / Q000008:administration & dosage
D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D014815:Vitamins