title: Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism.
abstract: The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5'' position.
authors: Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
authors: Toshiya
authors: T
authors: Takizawa
authors: Kazuhiro
authors: K
authors: Watanabe
authors: Koichi
authors: K
authors: Narita
authors: Takamasa
authors: T
authors: Oguchi
authors: Hideki
authors: H
authors: Abe
authors: Tadashi
authors: T
authors: Katoh
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D015394:Molecular Structure; D011549:Pseudomonas / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; C529984:spiruchostatin B