Atypical ischemic lower extremity ulcerations: a differential diagnosis.
Severe peripheral artery disease (PAD) is the predominant cause of ischemic ulcerations involving the lower extremities. PAD-associated ulcerations are typically distally located involving the feet, toes, and sometimes the calves. In contradistinction, atypical ischemic ulcerations of the lower extremity are often non-atherosclerotic in etiology, involve the proximal leg (thigh/buttocks), can evolve despite palpable distal pulses, and may coexist with other cutaneous aberrations (e.g. macules, purpura, nodules, and livedo reticularis). A differential diagnosis of atypical ischemic ulcerations involving the legs is presented.
Dean
Steven M
SM
Department of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio 43210, USA. steven.dean@osumc.edu
D000925:Anticoagulants / Q000009:adverse effects; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis; D002115:Calciphylaxis / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000150:complications / Q000175:diagnosis / Q000209:etiology; D017700:Embolism, Cholesterol / Q000150:complications / Q000175:diagnosis; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000209:etiology* / Q000473:pathology; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology; D035002:Lower Extremity / Q000098:blood supply*; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000175:diagnosis; D001098:Spider Bites / Q000150:complications / Q000175:diagnosis; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis; D014859:Warfarin / Q000009:adverse effects
D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin