Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection.
OBJECTIVE
To analyze the role of luteal E(2), P, and FSH levels in the prediction of clinical pregnancy in stimulated cycles.


METHODS
Prospective study.


METHODS
Institute of Reproductive Medicine, Salt Lake, Kolkata, India.


METHODS
A total of 268 women aged <40 years undergoing their first IVF-ET/intracytoplasmic sperm injection cycles.


METHODS
Estimation of luteal phase serum E(2), P, and FSH levels on days 0, 7, and 14 of ET.


METHODS
Comparison of luteal phase hormonal profile in pregnant and nonpregnant women and interpretation by discriminant analysis.


RESULTS
A total of 113 pregnancies were achieved (42.16%). Age, basal FSH level, peak E(2) level, number of oocytes retrieved, and number of embryos transferred were comparable between pregnant and nonpregnant women. Day-7 and day-14 luteal E(2) levels were significantly different between the two groups. Progesterone levels were comparable in both groups on days 0 and 14. Levels of FSH showed statistically significant differences between the two groups on days 0, 7, and 14. Classification accuracy for E(2), P, and FSH was 82.1%, 60.8%, and 67.51%, respectively.


CONCLUSIONS
Luteal E(2) concentration seems to be a promising marker of successful clinical pregnancy.
Ganesh
Ashalatha
A
School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India. asha@smst.iitkgp.ernet.in
Goswami
Sourendrakant
S
Chattopadhyay
Ratna
R
Chakraborty
Chandan
C
Chaudhury
Koel
K
Chakravarty
Baidya Nath
BN
D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D004958:Estradiol / Q000032:analysis / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D008183:Luteal Phase / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D011379:Prognosis; D012680:Sensitivity and Specificity; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
D015415:Biomarkers; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone