Transcription regulation through promoter-proximal pausing of RNA polymerase II.
Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.
Core
Leighton J
LJ
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Lis
John T
JT
D000818:Animals; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D014158:Transcription, Genetic
D012322:RNA Precursors; D012319:RNA Polymerase II