Panel construction for mapping in admixed populations via expected mutual information.
Mapping by admixture linkage disequilibrium (MALD) is an economical and powerful approach for the identification of genomic regions harboring disease susceptibility genes in recently admixed populations. We develop an information-theory-based measure, called expected mutual information (EMI), which computes the impact of a set of markers on the ability to infer ancestry at each chromosomal location. We then present a simple and effective algorithm for the selection of panels that strives to maximize the EMI score. Finally, we demonstrate via well-established simulation tools that our panels provide more power and accuracy for inferring disease gene loci via the MALD method in comparison to previous methods.
Bercovici
Sivan
S
Computer Science Department, Technion, Haifa 32000, Israel. sberco@cs.technion.ac.il
Geiger
Dan
D
Shlush
Liran
L
Skorecki
Karl
K
Templeton
Alan
A
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D005006:Ethnicity / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population / Q000379:methods*; D023281:Genomics / Q000379:methods; D006801:Humans; D007257:Information Theory; D015810:Linkage Disequilibrium
D005819:Genetic Markers