[Effect of N-stearoylethanolamine on the lipid peroxidation process and lipid composition of the rat liver in acute morphine intoxication].
The effect of N-stearoylethanolamine (NSE) on the lipid peroxidation process, antioxidant enzymes activity, phospholipid and fatty acid content in the rat liver tissues under acute morphine administration was studied. It was shown that morphine administration (30 mg/kg of body weight) caused an increase of the amount of thiobarbituric acid reactive substances (TBARS), alteration of antioxidant enzymes activity, decrease the protein level, quantity of total lipids and phospholipids, phosphatidylcholine, cholesterol esters; altered the content of some individual fatty acids. NSE administration (50 mg/kg of body weight) promoted normalization of the antioxidant enzymes activity and prevented the TBARS accumulation and decreased the total lipid and phospholipid quantity, increased the content of free and total cholesterol, corrected the level of free and individual fatty acids. It was assumed that NSE possessed antioxidative, membranoprotective and adaptive properties.
Horid'ko
T M
TM
Hula
N M
NM
Stohniĭ
N A
NA
Mehed'
O F
OF
Klimashevs'kyĭ
V M
VM
Shovkun
S A
SA
Kindruk
N L
NL
Berdyshev
A H
AH
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D004983:Ethanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D005227:Fatty Acids / Q000032:analysis* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D013229:Stearic Acids / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D004983:Ethanolamines; D005227:Fatty Acids; C408368:N-stearoylethanolamine; D013229:Stearic Acids; D009020:Morphine