title: Esthesioneuroblastoma: 25-year experience at a single institution.
abstract: OBJECTIVE
  To evaluate outcomes for patients with esthesioneuroblastoma treated at a single institution during a 25-year period.
  
  
  METHODS
  Eighteen patients with pathologic diagnosis of esthesioneuroblastoma between 1980 and 2004 were retrospectively identified.
  
  
  RESULTS
  Two patients had Kadish A, seven had Kadish B, and nine had Kadish C disease. The mean follow-up was 71 months. Treatment regimens consisted of surgery alone (four patients), surgery followed by postoperative radiation (six patients), surgery followed by postoperative chemoradiotherapy (three patients), preoperative radiotherapy (two patients), preoperative chemoradiotherapy (one patient), chemoradiotherapy (one patient), and surgery plus chemotherapy (one patient). Surgical approaches (n = 17) consisted of 13 traditional craniofacial resections, one endoscopic-assisted cranionasal resection, and three minimally invasive endoscopic resections. The 10-year disease-specific survival was 80%. The overall recurrence-free survival at five and 10 years was 62% and 46%, respectively. Positive surgical margins and TNM staging predicted survival.
  
  
  CONCLUSIONS
  Both endoscopic and open surgical approaches have been successful in treating a small number of esthesioneuroblastoma patients with high survival and low rate of surgical complications.
authors: Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
authors: Mark E
authors: ME
authors: Zafereo
authors: Samer
authors: S
authors: Fakhri
authors: Richard
authors: R
authors: Prayson
authors: Pete S
authors: PS
authors: Batra
authors: Joung
authors: J
authors: Lee
authors: Donald C
authors: DC
authors: Lanza
authors: Martin J
authors: MJ
authors: Citardi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D018304:Esthesioneuroblastoma, Olfactory / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D037981:Neck Dissection; D009669:Nose Neoplasms / Q000401:mortality / Q000601:surgery*; D011829:Radiation Dosage; D012189:Retrospective Studies