title: Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma.
abstract: This study examined six different polymer and self-assembled monolayer (SAM) surface modifications for their interactions with human serum and plasma. It was demonstrated that zwitterionic polymer surfaces are viable alternatives to more traditional surfaces based on poly(ethylene glycol) (PEG) as nonfouling surfaces. All polymer surfaces were formed using atom transfer radical polymerization (ATRP) and they showed an increased resistance to nonspecific protein adsorption compared to SAMs. This improvement is due to an increase in the surface packing density of nonfouling groups on the surface, as well as a steric repulsion from the flexible polymer brush surfaces. The zwitterionic polymer surface based on carboxybetaine methacrylate (CBMA) also incorporates functional groups for protein immobilization in the nonfouling background, making it a strong candidate for many applications such as in diagnostics and drug delivery.
authors: Department of Chemical Engineering, University of Washington, Box 351750, Seattle, Washington 98195, USA.
authors: Jon
authors: J
authors: Ladd
authors: Zheng
authors: Z
authors: Zhang
authors: Shengfu
authors: S
authors: Chen
authors: Jason C
authors: JC
authors: Hower
authors: Shaoyi
authors: S
authors: Jiang
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry*; D006801:Humans; D007477:Ions; D010949:Plasma; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids; D044967:Serum
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D007477:Ions; D011108:Polymers; D011109:Polymethacrylic Acids