title: Allosteric properties of hemoglobin and the plasma membrane of the erythrocyte: new insights in gas transport and metabolic modulation.
abstract: Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo- and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand-linked quaternary transition of hemoglobin in the control of "NO bioactivity" and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule.
authors: Institute of Biochemistry and Clinical Biochemistry, CNR Institute of Chemistry of Molecular Recognition, Catholic University of Rome, Rome, Italy.
authors: Maria Cristina
authors: MC
authors: De Rosa
authors: Cristiana
authors: C
authors: Carelli Alinovi
authors: Antonio
authors: A
authors: Galtieri
authors: Annamaria
authors: A
authors: Russo
authors: Bruno
authors: B
authors: Giardina
mesh_terms: D019794:2,3-Diphosphoglycerate / Q000097:blood; D000494:Allosteric Regulation; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D004058:Diffusion; D004910:Erythrocyte Membrane / Q000502:physiology*; D005740:Gases / Q000097:blood; D006019:Glycolysis; D006454:Hemoglobins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances / Q000378:metabolism; D010084:Oxidation-Reduction; D026403:S-Nitrosothiols / Q000097:blood
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D001786:Blood Glucose; D005740:Gases; D006454:Hemoglobins; D046911:Macromolecular Substances; D026403:S-Nitrosothiols; C103574:S-nitrosohemoglobin; D019794:2,3-Diphosphoglycerate