Phylogeny of Lagos bat virus: challenges for lyssavirus taxonomy.
Lagos bat virus (LBV) belongs to genotype 2 of the Lyssavirus genus. The complete nucleoprotein (N), phosphoprotein (P), matrixprotein (M) and glycoprotein (G) genes of 13 LBV isolates were sequenced and phylogenetically compared with other lyssavirus representatives. The results identified three different lineages of LBV. One of these lineages demonstrated sufficient sequence diversity to be considered a new lyssavirus genotype (Dakar bat lyssavirus). The suggested quantitative separation of lyssavirus genotypes using the N, P, M and G genes was also investigated using P-distances matrixes. Results indicated that the current criteria should be revised since overlaps between intergenotypic and intragenotypic variation occur.
Markotter
W
W
Department of Microbiology and Plant Pathology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa. wanda.markotter@up.ac.za
Kuzmin
I
I
Rupprecht
C E
CE
Nel
L H
LH
D000818:Animals; D014644:Genetic Variation; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D018114:Lyssavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics; D010802:Phylogeny; D018353:Rhabdoviridae Infections / Q000662:veterinary* / Q000821:virology*; D017385:Sequence Homology; D014764:Viral Proteins / Q000235:genetics
D006023:Glycoproteins; D009698:Nucleoproteins; D010750:Phosphoproteins; D014764:Viral Proteins