title: Microwave-assisted ring-opening of activated aziridines with resin-bound amines.
abstract: This paper describes the first study of nucleophilic ring-opening of nosylamide-activated aziridines under microwave irradiation conditions in solid-phase synthesis (SPS). The effects of solvent, temperature, reaction time, and reagent ratio in SPS of partially protected triamines from aziridines and resin-bound diamines were investigated. The methodology was also optimized for the synthesis of novel amino acid derivatives.
authors: Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors: François
authors: F
authors: Crestey
authors: Matthias
authors: M
authors: Witt
authors: Karla
authors: K
authors: Frydenvang
authors: Dan
authors: D
authors: Staerk
authors: Jerzy W
authors: JW
authors: Jaroszewski
authors: Henrik
authors: H
authors: Franzyk
mesh_terms: D000588:Amines / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D000588:Amines; D001388:Aziridines