title: Molecular aspects of Dengue virus replication.
abstract: Dengue virus (DENV)--a mosquito transmitted pathogen--is the causative agent of Dengue fever, the most important arboviral disease of humans, which affects an estimated 50-100 million people annually. Despite the high morbidity and mortality associated with DENV infections, an effective DENV vaccine and antiviral therapies are still missing. An improved understanding of the molecular mechanisms underlying the different steps of the DENV replication cycle, for example, genome replication and virus maturation, could help to develop such substances. Over the past several years, many important findings have been published with respect to a better understanding of DENV replication. In this review we will highlight recent insights into the molecular mechanisms of the viral replication cycle.
authors: Department of Molecular Virology, Im Neuenheimer Feld 345, University of Heidelberg, D-69120 Heidelberg, Germany. ralf_bartenschlager@med.uni-heidelberg.de
authors: Ralf
authors: R
authors: Bartenschlager
authors: Sven
authors: S
authors: Miller
mesh_terms: D003716:Dengue Virus / Q000235:genetics* / Q000254:growth & development*; D016679:Genome, Viral; D008954:Models, Biological; D014779:Virus Replication