title: Reactive oxygen species and HIF-1 signalling in cancer.
abstract: The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumour initiation and progression. Malfunction of the HIF-1 signalling network has been associated with breast, ovarian and prostate cancers. Elevated reactive oxygen species (ROS), also observed in such tumours, have been implicated in HIF-1 signalling. Deciphering the role of ROS in cancer onset and their involvement in signalling networks should prove invaluable for the design of novel anticancer therapeutics.
authors: Laboratory of Gene Expression, Molecular Diagnosis and Modern Therapeutics, Department of Molecular Biology and Genetics, Democritus University of Thrace, Dimitras 19, 68100 Alexandroupolis, Greece.
authors: Alex
authors: A
authors: Galanis
authors: Aglaia
authors: A
authors: Pappa
authors: Antonis
authors: A
authors: Giannakakis
authors: Evripidis
authors: E
authors: Lanitis
authors: Denarda
authors: D
authors: Dangaj
authors: Raphael
authors: R
authors: Sandaltzopoulos
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology*; D051379:Mice; D035683:MicroRNAs / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D051793:Hypoxia-Inducible Factor 1; D035683:MicroRNAs; D017382:Reactive Oxygen Species