title: RETRACTED: Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
  
  At the request of the University of Wyoming, this article has been retracted. The University of Wyoming's institutional investigation of the work authored by Dr. Jun Ren found evidence of data irregularities in Figures 2, 3 and 4 that affect the reported results and conclusions. All authors have been notified of the retraction of this article.
authors: Center for Cardiovascular Research and Alternative Medicine, University of Wyoming School of Pharmacy, Laramie, WY 82071, USA.
authors: Shi-Yan
authors: SY
authors: Li
authors: Center for Cardiovascular Research and Alternative Medicine, University of Wyoming School of Pharmacy, Laramie, WY 82071, USA. Electronic address: jren@uwyo.edu.
authors: Jun
authors: J
authors: Ren
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000201:enzymology* / Q000235:genetics; D002492:Central Nervous System Depressants / Q000378:metabolism / Q000633:toxicity*; D004721:Endoplasmic Reticulum / Q000201:enzymology* / Q000235:genetics; D000091342:Endoplasmic Reticulum Chaperone BiP; D004722:Endoribonucleases / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D050991:GATA4 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000235:genetics; D016758:Genes, jun / Q000187:drug effects / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects / Q000235:genetics; D032383:Myocytes, Cardiac / Q000201:enzymology; D010766:Phosphorylation / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics; D051742:Transcription Factor CHOP
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002492:Central Nervous System Depressants; C497250:Ddit3 protein, mouse; D000091342:Endoplasmic Reticulum Chaperone BiP; D015852:Eukaryotic Initiation Factor-2; D050991:GATA4 Transcription Factor; C484171:Gata4 protein, mouse; D006360:Heat-Shock Proteins; C000717248:Hspa5 protein, mouse; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D018832:Molecular Chaperones; D051742:Transcription Factor CHOP; D000431:Ethanol; D000426:Alcohol Dehydrogenase; C510185:Ern1 protein, mouse; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D004722:Endoribonucleases; D000079:Acetaldehyde; D005947:Glucose