Mixture design applied to optimize a directly compressible powder produced via cospray drying.
Coprocessing via spray drying was applied to improve the compactability of acetaminophen and to select an optimal formulation. Four-component mixtures containing acetaminophen, mannitol, erythritol, and maltodextrin were produced by cospray drying. A D-optimal mixture design was constructed to evaluate the spray dried powder and tablet properties. An increasing mannitol and erythritol content improved powder flowability and density. However, a higher erythritol concentration in the spray dried powder mixture had a negative influence on tablet tensile strength and friability. A higher maltodextrin content increased tablet tensile strength and improved tablet friability, while disintegration time, average particle size, powder flowability, density, and hygroscopicity were negatively influenced.
Gonnissen
Yves
Y
Laboratory of Pharmaceutical Technology, Ghent University, Gent, Belgium.
Gonçalves
Sara Isabel Vieira
SI
Remon
Jean Paul
JP
Vervaet
Chris
C
D000082:Acetaminophen / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004896:Erythritol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D008353:Mannitol / Q000737:chemistry; D008956:Models, Chemical; D010316:Particle Size; D011134:Polysaccharides / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013718:Tensile Strength; D017155:Wettability
D005079:Excipients; D011134:Polysaccharides; D011208:Powders; D013607:Tablets; D000082:Acetaminophen; D008353:Mannitol; C008315:maltodextrin; D004896:Erythritol