Complete resolution of Paget disease of the vulva with imiquimod cream.
Extra mammary Paget disease (EMPD) is a neoplastic disease of apocrine gland bearing skin. Surgical excision is the standard of care for EMPD; however, it is accompanied by recurrence in more than 60% of the patients. Recently, imiquimod cream has been reported to induce complete responses in primary or recurrent EMPD. We report on 2 women with vulva EMPD who achieved biopsy-confirmed resolution of their disease after topical application of imiquimod 5% cream.
Hatch
Kenneth D
KD
University of Arizona, Tucson, AZ 85724-5078, USA. khatch@u.arizona.edu
Davis
John R
JR
D000287:Administration, Topical; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D008297:Male; D009824:Ointments; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology; D014622:Vaginal Creams, Foams, and Jellies; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000634:Aminoquinolines; D000970:Antineoplastic Agents; D009824:Ointments; D014622:Vaginal Creams, Foams, and Jellies; D000077271:Imiquimod