Histone deacetylase inhibitors in lymphoma and solid malignancies.
Histone deacetylase inhibitors (HDACi) are a new class of antineoplastic agents with demonstrable preclinical antitumor activity in both in vitro and in vivo studies in a wide range of malignancies. Based on these preclinical findings, in recent years HDACi have undergone a rapid phase of clinical development with many HDACi entering Phase I-III clinical trials, both as single agents and in combination with other therapies. Favorable clinical responses have been demonstrated in cutaneous T-cell lymphoma with emerging evidence of clinical activity in other types of lymphoma and, to date, a good toxicity profile. Solid tumor responses to single agent and combination therapies have also been reported, paving the way for larger studies in this field. In this review we discuss the recent advances in the clinical development of HDACi and their current therapeutic role in lymphoma and solid malignancies.
Rasheed
Walid
W
Division of Haematology & Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Melbourne, Victoria 8006, Australia. walid.rasheed@petermac.org
Bishton
Mark
M
Johnstone
Ricky W
RW
Prince
H Miles
HM
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D047630:Depsipeptides / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000627:therapeutic use; D007211:Indoles; D008223:Lymphoma / Q000188:drug therapy* / Q000201:enzymology; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D000077767:Panobinostat; D011725:Pyridines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D000077337:Vorinostat
D000970:Antineoplastic Agents; D001549:Benzamides; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D007211:Indoles; D011725:Pyridines; D011743:Pyrimidines; C118739:entinostat; D000077337:Vorinostat; D000077767:Panobinostat; C523184:mocetinostat; C087123:romidepsin