[Effect of hypoxia on dedifferentiation of mature adipocytes: an experimental study].
OBJECTIVE
To study the morphological changes of mature adipocytes in hypoxic condition in vitro and investigate the effect of hypoxia on dedifferentiation of mature adipocytes.


METHODS
Human adipose tissue was collected from individuals undergoing liposuction procedures, from which the stem cells were isolated and induced to become mature adipocytes. After cell culture in hypoxic condition, the adipocytes were observed for morphological changes at different time points.


RESULTS
After a few days of culture in hypoxic condition, the mature adipocytes derived from the adipose tissue-derived stem cells underwent morphological changes from spherical cells into fibroblast-like cells capable of continuous cell division.


CONCLUSIONS
Mature adipocytes may dedifferentiate into fibroblast-like cells under appropriate conditions.
Liao
Yun-jun
YJ
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Gao
Jian-hua
JH
Jiang
Ping
P
Lu
Feng
F
D017667:Adipocytes / Q000166:cytology*; D000273:Adipose Tissue / Q000166:cytology; D000293:Adolescent; D000328:Adult; D002454:Cell Differentiation / Q000502:physiology*; D015687:Cell Hypoxia; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D013234:Stem Cells / Q000166:cytology; D055815:Young Adult