Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall).
Abnormalities in GABA levels in the central nucleus of the inferior colliculus (CNIC) of the epilepsy-prone hamster (GPG/Vall) were evaluated by using immunohistochemistry, densitometry and high performance liquid chromatography (HPLC). These findings demonstrate a decrease both in GABA immunostaining (neuropil and neurons) and in GABA concentration (HPLC) in the CNIC of the epileptic hamster compared to control animals. These decreases may reflect a reduced availability of this neurotransmitter that may act as an audiogenic seizure-initiating factor.
Fuentes-Santamaría
Verónica
V
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1010, USA. vfuentes@wfubmc.edu
Alvarado
Juan Carlos
JC
Herranz
Antonio S
AS
García-Atarés
Natividad
N
López
Dolores E
DE
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D003720:Densitometry; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007245:Inferior Colliculi / Q000378:metabolism*; D008647:Mesocricetus; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid