title: Cytoskeletal transition at the paranodes: the Achilles' heel of myelinated axons.
abstract: Myelination organizes axons into distinct domains that allow nerve impulses to propagate in a saltatory manner. The edges of the myelin sheath are sealed at the paranodes by axon-glial junctions that have a crucial role in organizing the axonal cytoskeleton. Here we propose a model in which the myelinated axons depend on the axon-glial junctions to stabilize the cytoskeletal transition at the paranodes. Thus paranodal regions are likely to be particularly susceptible to damage induced by demyelinating diseases such as multiple sclerosis.
authors: Department of Cell and Molecular Physiology, Curriculum in Neurobiology, Neurodevelopmental Disorders Research Center and UNC-Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors: Aurea D
authors: AD
authors: Sousa
authors: Manzoor A
authors: MA
authors: Bhat