Postural sway and effect of levodopa in early Parkinson's disease.
OBJECTIVE
To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD).


METHODS
Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined.


RESULTS
Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition.


CONCLUSIONS
Postural control mechanisms are affected early in PD and modulated by dopamine.
Beuter
Anne
A
Institut de Cognitique, Université Victor Segalen Bordeaux 2, Bordeaux, France.
Hernández
Roberto
R
Rigal
Robert
R
Modolo
Julien
J
Blanchet
Pierre J
PJ
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D004298:Dopamine / Q000502:physiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology*; D004856:Postural Balance / Q000187:drug effects / Q000502:physiology*
D000978:Antiparkinson Agents; D007980:Levodopa; D004298:Dopamine