title: Visualization of hypervascular liver lesions During TACE: comparison of angiographic C-arm CT and MDCT.
abstract: OBJECTIVE
  The purpose of our study was to evaluate the diagnostic accuracy and scan coverage of flat-detector C-arm CT compared with that of biphasic MDCT for depicting malignant hepatic lesions in patients with hypervascular liver tumors before they undergo transarterial chemoembolization (TACE).
  
  
  METHODS
  Fifteen patients with either hepatocellular carcinoma (HCC, n = 8) or hypervascular liver metastases from uveal melanoma (n = 7) underwent arterial and portal venous C-arm CT of the liver using intraarterial contrast media administration directly before TACE. The number and location of their hepatic malignancies were compared with those on MDCT. The scan coverage was documented and the liver diameter measured on MDCT.
  
  
  RESULTS
  Compared with MDCT, the sensitivity and specificity for segmental tumor involvement were 97% (76/78) and 85% (28/33), respectively, for reader 1, and 99% (77/78) and 79% (24/29), respectively, for reader 2. Complete scan coverage of the liver was obtained in five of the 15 patients with C-arm CT. In patients with incomplete scan coverage on C-arm CT, the craniocaudal liver diameter was significantly larger than in those patients with complete scan coverage (mean [95% CI], 22.7 [19.5-25.9] cm vs 20.2 [15.4-25.0] cm, p = 0.0193).
  
  
  CONCLUSIONS
  Biphasic arterial and portal venous C-arm CT showed a high sensitivity for the detection of malignant liver lesions. However, the liver could not be visualized completely in two thirds of the patients. Therefore, the current scan range limitations need to be overcome to make C-arm CT a valuable adjunct to MDCT for preprocedure evaluation and postprocedure follow-up imaging.
authors: Department of Radiology and Nuclear Medicine, Charité-University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. Bernhard.Meyer@charite.de
authors: Bernhard C
authors: BC
authors: Meyer
authors: Bernd B
authors: BB
authors: Frericks
authors: Maerthe
authors: M
authors: Voges
authors: Michael
authors: M
authors: Borchert
authors: Peter
authors: P
authors: Martus
authors: Joern
authors: J
authors: Justiz
authors: Karl-Juergen
authors: KJ
authors: Wolf
authors: Frank K
authors: FK
authors: Wacker
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D003287:Contrast Media; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000628:therapy*; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000473:pathology
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide