Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature.
Renal involvement in paroxysmal nocturnal hemoglobinuria (PNH) is usually clinically not apparent but, in cases with clinical involvement, varies from reversible acute dysfunction to chronic irreversible damage. We report two cases of acute kidney injury and one case of chronic kidney disease due to PNH. In all three cases a diagnosis of PNH was made after detection of renal dysfunction. The renal involvement was documented on both histology and on imaging studies. Finally, we briefly review the main literature data on renal involvement in PNH.
Nair
R K
RK
Department of Nephrology, All India Institute of Medical Sciences, Ansari Nagar 110029, New Delhi, India.
Khaira
Ambar
A
Sharma
Alok
A
Mahajan
Sandeep
S
Dinda
Amit K
AK
D000368:Aged; D005434:Flow Cytometry; D005938:Glucocorticoids / Q000627:therapeutic use; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006486:Hemosiderosis / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use
D005938:Glucocorticoids; D011241:Prednisone