[Nephrotic syndrome in the elderly. Treatment of the nephrotic syndrome in the elderly (part II)].
Nephrotic syndrome (NS) in elderly may increase mortality. The severity of NS determines its management. In the milder forms, with serum albumin concentrations greater than 2.5 mg/dl, significant sodium retention, volume expansion and hypertension patients should be treated with diuretics and hypertensive agents alone. Hypercholesterolemia needs to be treated in patients with NS because this is an important contributor to progressive loss of renal function and increased morbidity and mortality from cardiovascular disease in patients with renal insufficiency Statins decrease proteinuria and have antinflammatory action. Patients with severe NS will likely require immunosuppressive agents to significantly reduce heavy proteinuria. Elderly individuals should receive an appropriate immunosuppressive therapy to induce remission of NS and reduce the risk of progressive loss of renal function. However, since side effects of the used drugs and infectious complications occur more frequently in elderly, careful monitoring of therapy should be carried out.
Szmyt
Mirosław
M
Uniwersytet Medyczny w Poznaniu, Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych.
Niemir
Zofia I
ZI
Czekalski
Stanisław
S
D000368:Aged; D000418:Albumins / Q000032:analysis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology*; D009404:Nephrotic Syndrome / Q000188:drug therapy*
D000418:Albumins; D007166:Immunosuppressive Agents