[Antioxidant activity of condensed [1,2,4]-triazinone derivatives in nitrosative stress].
Antioxidant activity of nine [1,2,4]-triazinone derivatives was studied in the work. Our data show that [1,2,4]-triazinone derivatives with benzyl alcohol, propyl alcohol, me-thyl alcohol and tolyl residues in their structure have antioxidant activity in condition of in vitro NO formation. KO-17 compound proved to have the greatest antioxidant activity which exceeded N-acetyl cysteine's one.
Hubs'kyĭ
Iu I
IuI
Belenichev
I F
IF
Levyts'kyĭ
Ie L
IeL
Halytsia
V V
VV
Bukhtiiarova
N V
NV
Kovalenko
S I
SI
Babenko
L P
LP
Zadoryna
O V
OV
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008956:Models, Chemical; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000378:metabolism; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology*
D000975:Antioxidants; D020030:Nitric Oxide Donors; D014227:Triazines; D009569:Nitric Oxide; D013482:Superoxide Dismutase