T cell homeostasis.
The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4(+) and CD8(+) cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various gamma(c) cytokines, plays a decisive role in controlling normal T cell homeostasis.
Sprent
Jonathan
J
Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. j.sprent@garvan.org.au
Cho
Jae-Ho
JH
Boyman
Onur
O
Surh
Charles D
CD
D000375:Aging; D000818:Animals; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines