[P-glycoprotein and human immunodeficiency virus infection].
P-glycoprotein (PGP) is a membrane protein and product of the MDR-1 gene, which acts as an efflux pump for several drugs, such as protease inhibitors (PI) used in HIV. Numerous studies in vitro, in experimental animals, and in patients have analyzed the relationships between PGP and the pharmacokinetic and pharmacodynamic properties of antiretroviral agents, with differing conclusions. In addition, studies focusing on the impact of single nucleotide polymorphisms in the MDR-1 gene, mainly C3435T in exon 26 and G2677A/G2677T in exon 21, on antiretroviral plasma concentrations, efficacy and adverse effects, have reported varying results, which have been attributed to the influence of other polymorphisms, such as cytochrome P450.
Peralta
Galo
G
Servicio de Medicina Interna, Hospital Sierrallana, Torrelavega, Cantabria, Spain. gpf@mundivia.es
Sánchez
María Blanca
MB
Echevarría
Santiago
S
Valdizán
Elsa María
EM
Armijo
Juan Antonio
JA
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects* / Q000502:physiology*; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D044966:Anti-Retroviral Agents