Diversity-oriented synthesis; a spectrum of approaches and results.
Since our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space and in the identification of novel biologically active lead compounds, is also discussed.
Spandl
Richard J
RJ
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB1 1EW.
Bender
Andreas
A
Spring
David R
DR
D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D010597:Pharmacogenetics / Q000379:methods*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D012984:Software
D016861:Cyclooxygenase Inhibitors; D054852:Small Molecule Libraries