title: Brain tumor perfusion: comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and T2* contrast, pulsed arterial spin labeling, and H2(15)O positron emission tomography.
abstract: OBJECTIVE
  Different techniques for measuring of perfusion are clinically available, but these are usually applied to healthy brain tissue.
  
  
  METHODS
  Five different techniques were used here in 12 patients with brain tumors to investigate the impact of tumor vascularization on the perfusion signal: three qualitative dynamic contrast-enhanced/susceptibility-contrast magnetic resonance imaging (DCE-MRI/DSC-MRI) techniques exploiting T(1), T(2), T(2)(*) contrast, and two quantitative techniques, pulsed arterial spin labeling (PASL) and H(2)(15)O positron emission tomography (H(2)(15)O-PET).
  
  
  RESULTS
  In a first approximation, a linear correlation was found between all five imaging modalities regarding the perfusion signal of both, normal brain tissue and tumor. The estimated values for tumor perfusion differed significantly between the techniques (1=methodical mean in arbitrary units): PASL: 0.83, H(2)(15)O-PET: 0.62, T(1)-DCE: 1.73, T(2)-DCE: 0.69, T(2)(*)-DSC: 0.89.
  
  
  CONCLUSIONS
  The tumor perfusion values, determined with different techniques are not comparable. The T(2)(*)-DSC, here applied with contrast agent presaturation of extravascular space, and PASL depict median perfusion most reliably.
authors: Department of Radiation Medicine, Universitätsklinikum Charité, Campus Virchow-Klinikum, Berlin, Germany. lutz.luedemann@charite.de
authors: Lutz
authors: L
authors: Lüdemann
authors: Carsten
authors: C
authors: Warmuth
authors: Michail
authors: M
authors: Plotkin
authors: Annette
authors: A
authors: Förschler
authors: Matthias
authors: M
authors: Gutberlet
authors: Peter
authors: P
authors: Wust
authors: Holger
authors: H
authors: Amthauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D003287:Contrast Media; D019786:Gadolinium DTPA; D005910:Glioma / Q000098:blood supply / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D010103:Oxygen Isotopes; D055420:Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D014867:Water; D055815:Young Adult
chemical_list: D003287:Contrast Media; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D013113:Spin Labels; D014867:Water; D019786:Gadolinium DTPA