title: Primary intravascular synovial sarcoma of the femoral vein in a male patient, case report.
abstract: Synovial Sarcoma (SS) is an aggressive neoplasm commonly affecting deep soft tissues of the extremities. In rare instances SS can arise in large veins of the lower extremities or trunk. We report the first case of intravascular synovial sarcoma (IVSS) occurring in a male patient. A biphasic tumor was diagnosed by histology and immunohistochemistry. Molecular analysis at RNA level confirmed the diagnosis demonstrating the chromosomal translocation t(X;18) (p11.2;q11.2) in the tumor. Although extremely rare, IVSS should be considered in the differential diagnosis of primary intravascular neoplasms and as a potential cause of deep vein thrombosis and thromboembolism.
authors: Operative Unit of Vascular and Endovascular Surgery, S. Anna University-Hospital, Ferrara, Italy. Electronic address: cnomtt@unife.it.
authors: M
authors: M
authors: Coen
authors: Department of Biochemistry and Molecular Biology, University of Ferrara, Italy.
authors: T
authors: T
authors: Gagliano
authors: Operative Unit of Vascular and Endovascular Surgery, S. Anna University-Hospital, Ferrara, Italy.
authors: E
authors: E
authors: Tsolaki
authors: Department of Biochemistry and Molecular Biology, University of Ferrara, Italy.
authors: G
authors: G
authors: Marchetti
authors: Operative Unit of Surgical Pathology and Cytopathology, S. Anna University-Hospital, Ferrara, Italy.
authors: E
authors: E
authors: Marchetti
authors: Operative Unit of Vascular and Endovascular Surgery, S. Anna University-Hospital, Ferrara, Italy.
authors: F
authors: F
authors: Mascoli
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D005268:Femoral Vein / Q000473:pathology* / Q000601:surgery; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008026:Ligation; D008297:Male; D011152:Popliteal Vein / Q000473:pathology* / Q000601:surgery; D012334:RNA, Neoplasm / Q000032:analysis; D013584:Sarcoma, Synovial / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014656:Vascular Surgical Procedures; D020246:Venous Thrombosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy
chemical_list: D000925:Anticoagulants; D012334:RNA, Neoplasm