title: Osteogenic capacities of tibial and cranial periosteum: a biochemical and histologic study.
abstract: The periosteum has an important role in bone regeneration. The purpose of this study was to evaluate and compare the osteogenic capacities of tibial and cranial periosteum. To achieve this, 44 New Zealand male rabbits were divided into two groups, each consisting of 22 rabbits. In group 1, periosteal flaps were prepared on the tibia of the posterior cruris of each side. In group 2, bilateral periosteal flaps were prepared on the cranial region. New bone formation was estimated quantitatively by measuring the alkaline phosphatase and osteocalcin levels, because they are the indicators of osteoblastic activity. At weeks 1, 2, 4, and 8, biopsies were taken from five animals of each group for biochemical analyses, and at weeks 2 and 8, biopsies were taken for histologic evaluation. Higher alkaline phosphatase and osteocalcin levels were evaluated in group 1, and more bone formation was observed in group 1. The results showed that osteogenic capacity is higher in tibial periosteum than cranial periosteum.
authors: Department of Plastic and Reconstructive Surgery, Ege University, Izmir, Turkey. ubilkay@hotmail.com
authors: Ufuk
authors: U
authors: Bilkay
authors: Cenk
authors: C
authors: Tokat
authors: Evren
authors: E
authors: Helvaci
authors: Cuneyt
authors: C
authors: Ozek
authors: Osman
authors: O
authors: Zekioglu
authors: Taner
authors: T
authors: Onat
authors: Ecmel
authors: E
authors: Songur
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D001861:Bone Regeneration / Q000502:physiology; D004396:Coloring Agents; D008297:Male; D010006:Osteoblasts / Q000502:physiology; D015675:Osteocalcin / Q000032:analysis; D010012:Osteogenesis / Q000502:physiology*; D010521:Periosteum / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D011817:Rabbits; D012886:Skull / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D013524:Surgical Flaps / Q000473:pathology; D013977:Tibia / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004396:Coloring Agents; D015675:Osteocalcin; D000469:Alkaline Phosphatase