[The influence of vitamins A, E, C upon the respiration activity of the spleen lymphocytes ].
In the experiment on albino male mongrel rats some parameters of oxidative phosphorylation of spleen slices were studied after the animals were fed the antioxidant complex of vitamins E, A, and C. The stimulation of oxygen consumption rate and of tissue respiration of spleen was observed with endogenous substrates, and after exogenous substrates (succinate and glutamate) were added. After the ingestion of vegetable oil the uncoupling of oxidative phosphorylation was observed. The perspectives of alimentary and medicine immunocorrection by the influence upon the mitochondrial oxidation system of cell immune competence organ discussed.
Gritsuk
A I
AI
Kader
A
A
Koval'
A N
AN
Sergeenko
S M
SM
Svergun
V T
VT
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D010938:Plant Oils / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000378:metabolism*; D014801:Vitamin A / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D010938:Plant Oils; D014801:Vitamin A; D014810:Vitamin E; D001205:Ascorbic Acid