title: Acute models of ethanol exposure to mice.
abstract: Acute alcohol administration has minimal effects on basal immune function. However, when the immune system is challenged, acute alcohol administration alters the immune system's response. In the first 3 h after infection or traumatic injury, the presence of alcohol is associated with a decreased inflammatory response. This defect lasts long after the alcohol is cleared. Conversely, by 48 h after traumatic injury, the presence of alcohol is associated with a heightened inflammatory response. Aside from its in vivo actions, systemic administration of alcohol also alters the ex vivo response of immune cells, resulting in a decreased production of multiple cytokines after stimulation by lipopolysaccharide, concanavilin A, zymosan, and CpG DNA. Here, we describe a standardized model of acute administration of ethanol to mice used to study both the in vivo and ex vivo responses of immune cells to ethanol.
authors: Burn and Shock Trauma Institute, Departments of Surgery, Cell Biology, Neurobiology,and Anatomy, Alcohol Research Program, Loyola University Medical Center, Maywood, IL, USA.
authors: Timothy P
authors: TP
authors: Plackett
authors: Elizabeth J
authors: EJ
authors: Kovacs
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000428:Alcohol Drinking / Q000276:immunology / Q000378:metabolism; D000437:Alcoholism / Q000276:immunology / Q000378:metabolism; D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage* / Q000097:blood; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood; D007107:Immune System / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D051379:Mice; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol