title: Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.
abstract: Topical transcutaneous immunization (TCI) presents many clinical advantages, but its underlying mechanism remains unknown. TCI induced Ag-specific IgA Ab-secreting cells expressing CCR9 and CCR10 in the small intestine in a retinoic acid-dependent manner. These intestinal IgA Abs were maintained in Peyer's patch-null mice but abolished in the Peyer's patch- and lymph node-null mice. The mesenteric lymph node (MLN) was shown to be the site of IgA isotype class switching after TCI. Unexpectedly, langerin(+)CD8alpha(-) dendritic cells emerged in the MLN after TCI; they did not migrate from the skin but rather differentiated rapidly from bone marrow precursors. Depletion of langerin(+) cells impaired intestinal IgA Ab responses after TCI. Taken together, these findings suggest that MLN is indispensable for the induction of intestinal IgA Abs following skin immunization and that cross-talk between the skin and gut immune systems might be mediated by langerin(+) dendritic cells in the MLN.
authors: Mucosal Immunology Section, International Vaccine Institute, Seoul, Republic of Korea.
authors: Sun-Young
authors: SY
authors: Chang
authors: Hye-Ran
authors: HR
authors: Cha
authors: Osamu
authors: O
authors: Igarashi
authors: Paul D
authors: PD
authors: Rennert
authors: Adrien
authors: A
authors: Kissenpfennig
authors: Bernard
authors: B
authors: Malissen
authors: Masanobu
authors: M
authors: Nanno
authors: Hiroshi
authors: H
authors: Kiyono
authors: Mi-Na
authors: MN
authors: Kweon
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D000954:Antigens, Surface / Q000276:immunology*; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D007114:Immunization; D007070:Immunoglobulin A / Q000276:immunology; D007422:Intestines / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology*; D037241:Mannose-Binding Lectins / Q000276:immunology*; D008643:Mesentery / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000276:immunology*; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D000954:Antigens, Surface; C498497:Cd207 protein, mouse; D007070:Immunoglobulin A; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D014212:Tretinoin