The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience.
The reported neurodegeneration process in multiple sclerosis may explain the lack of efficacy of the currently used immunomodulating modalities and the irreversible axonal damage, which results in accumulating disability. Efforts for neuroprotective treatments have not been, so far, successful in clinical studies in other CNS diseases. Therefore, for MS, the use of stem cells may provide a logical solution, since these cells can migrate locally into the areas of white matter lesions (plaques) and have the potential to support local neurogenesis and rebuilding of the affected myelin. This may be achieved both by support of the resident CNS stem cells repertoire and by differentiation of the transplanted cells into neurons and myelin-producing cells (oligodendrocytes). Stem cells were also shown to possess immunomodulating properties, inducing systemic and local suppression of the myelin-targeting autoimmune lymphocytes. Several types of stem cells (embryonic and adult) have been described and extensively studied in animal models of CNS diseases. In this review, we summarize the experience with the use of different types of stem cells in the animal models of MS (EAE) and we describe the advantages and disadvantages of each stem cell type for future clinical applications in MS.
Karussis
Dimitrios
D
Department of Neurology, Laboratory of Neuroimmunology, Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Karem, Jerusalem, Israel. karus@cc.huji.ac.il
Kassis
Ibrahim
I
D053687:Adult Stem Cells / Q000637:transplantation; D000818:Animals; D003711:Demyelinating Diseases / Q000628:therapy; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000637:transplantation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D009103:Multiple Sclerosis / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation