title: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
abstract: In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association, rs3802842 on 11q23 (OR = 1.1; P = 5.8 x 10(-10)), showing population differences in risk. We also replicated and fine-mapped associations at 8q24 (rs7014346; OR = 1.19; P = 8.6 x 10(-26)) and 18q21 (rs4939827; OR = 1.2; P = 7.8 x 10(-28)). Risk was greater for rectal than for colon cancer for rs3802842 (P < 0.008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology.
authors: Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK.
authors: Albert
authors: A
authors: Tenesa
authors: Susan M
authors: SM
authors: Farrington
authors: James G D
authors: JG
authors: Prendergast
authors: Mary E
authors: ME
authors: Porteous
authors: Marion
authors: M
authors: Walker
authors: Naila
authors: N
authors: Haq
authors: Rebecca A
authors: RA
authors: Barnetson
authors: Evropi
authors: E
authors: Theodoratou
authors: Roseanne
authors: R
authors: Cetnarskyj
authors: Nicola
authors: N
authors: Cartwright
authors: Colin
authors: C
authors: Semple
authors: Andrew J
authors: AJ
authors: Clark
authors: Fiona J L
authors: FJ
authors: Reid
authors: Lorna A
authors: LA
authors: Smith
authors: Kostas
authors: K
authors: Kavoussanakis
authors: Thibaud
authors: T
authors: Koessler
authors: Paul D P
authors: PD
authors: Pharoah
authors: Stephan
authors: S
authors: Buch
authors: Clemens
authors: C
authors: Schafmayer
authors: Jürgen
authors: J
authors: Tepel
authors: Stefan
authors: S
authors: Schreiber
authors: Henry
authors: H
authors: Völzke
authors: Carsten O
authors: CO
authors: Schmidt
authors: Jochen
authors: J
authors: Hampe
authors: Jenny
authors: J
authors: Chang-Claude
authors: Michael
authors: M
authors: Hoffmeister
authors: Hermann
authors: H
authors: Brenner
authors: Stefan
authors: S
authors: Wilkening
authors: Federico
authors: F
authors: Canzian
authors: Gabriel
authors: G
authors: Capella
authors: Victor
authors: V
authors: Moreno
authors: Ian J
authors: IJ
authors: Deary
authors: John M
authors: JM
authors: Starr
authors: Ian P M
authors: IP
authors: Tomlinson
authors: Zoe
authors: Z
authors: Kemp
authors: Kimberley
authors: K
authors: Howarth
authors: Luis
authors: L
authors: Carvajal-Carmona
authors: Emily
authors: E
authors: Webb
authors: Peter
authors: P
authors: Broderick
authors: Jayaram
authors: J
authors: Vijayakrishnan
authors: Richard S
authors: RS
authors: Houlston
authors: Gad
authors: G
authors: Rennert
authors: Dennis
authors: D
authors: Ballinger
authors: Laura
authors: L
authors: Rozek
authors: Stephen B
authors: SB
authors: Gruber
authors: Koichi
authors: K
authors: Matsuda
authors: Tomohide
authors: T
authors: Kidokoro
authors: Yusuke
authors: Y
authors: Nakamura
authors: Brent W
authors: BW
authors: Zanke
authors: Celia M T
authors: CM
authors: Greenwood
authors: Jagadish
authors: J
authors: Rangrej
authors: Rafal
authors: R
authors: Kustra
authors: Alexandre
authors: A
authors: Montpetit
authors: Thomas J
authors: TJ
authors: Hudson
authors: Steven
authors: S
authors: Gallinger
authors: Harry
authors: H
authors: Campbell
authors: Malcolm G
authors: MG
authors: Dunlop
mesh_terms: D000328:Adult; D000368:Aged; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk