New, simple and versatile synthesis of 4,6-disubstituted pyridazin-3(2H)-ones.
A simple, two-step synthesis of 4,6-disubstituted pyridazin-3(2H)-ones starting from 2-diethoxyphosphoryl-4-oxoalkanoates and hydrazines is described. The intermediate 4-diethoxyphosphoryl-4,5-dihydropyridazin-3(2H)-ones obtained in this way are used in a Horner-Wadsworth-Emmons olefination of aldehydes to give a variety of disubstituted pyridazin-3(2H)-ones.
Albrecht
Anna
A
Institute of Organic Chemistry, Technical University of Łódź, Zeromskiego 116, 90-924, Łódź, Poland.
Koszuk
Jacek
J
Kobuciński
Michał
M
Janecki
Tomasz
T
D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*
D006834:Hydrazines; D011724:Pyridazines