title: Hemolysis after mitral valve repair: a report of five cases and literature review.
abstract: OBJECTIVE
  Hemolytic anemia is known to be a rare complication after the prosthetic replacement of the mitral valve, especially in the presence of perivalvular leaks, and even more rarely after mitral valve repair. Following repair, certain distinct patterns of the regurgitant flow disturbances associated with high shear stress are responsible for the hemolysis. Early echocardiographic recognition of these flow patterns may be important to diagnose the condition and may lead to re-repair or replacement of the valve.
  
  
  METHODS
  During the past eight years, mitral valve repair was performed by the present authors in 159 patients, with a prosthetic ring being placed in 130 cases. In five of the patients receiving rings (3.8%) however, intractable hemolytic anemia quickly developed, due to recurrent or residual mitral regurgitation, and this necessitated reoperation.
  
  
  RESULTS
  The valve was replaced in all five patients. One patient died from respiratory and renal failure leading to multiorgan failure. The other four patients were followed up and are currently in good health, with no evidence of hemolysis.
  
  
  CONCLUSIONS
  Hemolysis frequently occurs immediately or soon after mitral valve repair, and may even appear in mild regurgitation. Thus, following repair with a prosthetic ring it is essential to clearly visualize the dynamic flow patterns postoperatively with transesophageal echocardiography, focusing especially on probable fragmentation, collision and rapid acceleration jets. These findings may lead the surgeon to revise the repair, or to replace the valve.
authors: Department of Cardiovascular Surgery and Cardiology, Istanbul Memorial Hospital, Istanbul, Turkey.
authors: E
authors: E
authors: Demirsoy
authors: O
authors: O
authors: Yilmaz
authors: G
authors: G
authors: Sirin
authors: T
authors: T
authors: Baran
authors: S
authors: S
authors: Tekin
authors: D
authors: D
authors: Sener
authors: B
authors: B
authors: Sonmez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011183:Postoperative Complications; D012720:Severity of Illness Index