Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA  repair enzyme and DNA methylation in breast cancer patients undergoing  tamoxifen therapy.
In the present study, eighty-four breast cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d. A significant increase in poly(ADP-ribose) polymerase levels and disappearance of RASSF1A DNA methylation patterns were found in patients treated with supplement therapy along with tamoxifen compared to untreated breast cancer patients and tamoxifen alone-treated patients. An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment.
Premkumar
Vummidi Giridhar
VG
Department of Medical Biochemistry, DR. A.L.M. Post-Graduate, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India.
Yuvaraj
Srinivasan
S
Shanthi
Palanivel
P
Sachdanandam
Panchanatham
P
D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D019175:DNA Methylation / Q000187:drug effects*; D045643:DNA Repair Enzymes / Q000187:drug effects* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D012256:Riboflavin / Q000627:therapeutic use; D016037:Single-Blind Method; D013629:Tamoxifen / Q000627:therapeutic use*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use
D018931:Antineoplastic Agents, Hormonal; D004273:DNA, Neoplasm; D013629:Tamoxifen; D014451:Ubiquinone; D009525:Niacin; D011065:Poly(ADP-ribose) Polymerases; D045643:DNA Repair Enzymes; C024989:coenzyme Q10; D012256:Riboflavin