title: [Antibodies against Trypanosoma cruzi in intact mice and their oncoprotective effect].
abstract: Trypanosoma cruzi antibodies that are important in the anticancer effect of this species of Trypanosoma were first detected in 14% of the 374 examined intact mice. These background antibodies were polyclonal, i.e. they reacted with one or other of 9 genetically different T. cruzi clones and detected antigenic determinants in different structures of a Trypanosoma cell. Their spread in the population varied with animal batches; the titers were not greater than 1:40 and the level remained steady during a one-month observation. The growth of Ehrlich's adenomacarcinoma inoculated to these mice was inhibited by 1.5-2.5 times and, in some cases, terminated in total regression. The paper discusses the capacities of such antibodies in man and their inductor-commonness of the antigens of the normal intestinal microflora and the cells of the vertebrate with T. cruzi.
authors: V D
authors: VD
authors: Kallinikova
authors: Ts
authors: Ts
authors: Batmonkh
authors: E N
authors: EN
authors: Kosobokova
authors: L V
authors: LV
authors: Pakhorukova
authors: T A
authors: TA
authors: Ogloblina
authors: E G
authors: EG
authors: Kravtsov
authors: L P
authors: LP
authors: Karpenko
authors: P V
authors: PV
authors: Matekin
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology; D000970:Antineoplastic Agents / Q000097:blood* / Q000276:immunology; D002286:Carcinoma, Ehrlich Tumor / Q000175:diagnosis / Q000276:immunology*; D018450:Disease Progression; D051379:Mice; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000970:Antineoplastic Agents