Treatment of a nonhealing saphenous vein harvest graft with treprostinil sodium.
Impaired healing of saphenous vein harvest sites is a serious but under-recognized complication of coronary artery bypass grafting surgery, particularly in the presence of peripheral arterial disease. We report the use of a continuous subcutaneous infusion of treprostinil sodium, an analog of prostacyclin, to treat a limb-threatening, nonhealing saphenous vein harvest incision site after myocardial revascularization.
Zwicke
Dianne
D
Comprehensive Cardiovascular Care Group, Milwaukee, Wisconsin 53215, USA. dzwicke1@yahoo.com
Buggy
Brian
B
Lobacz
Don
D
Rollins
Kristan
K
Strootman
Deborah
D
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D003327:Coronary Disease / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D016491:Peripheral Vascular Diseases / Q000150:complications; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy; D018570:Risk Assessment; D012501:Saphenous Vein / Q000637:transplantation*; D020858:Tissue and Organ Harvesting / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000209:etiology
D011464:Epoprostenol; C427248:treprostinil