Isoxazolone based inhibitors of p38 MAP kinases.
SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.
Laufer
Stefan A
SA
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany. stefan.laufer@uni-tuebingen.de
Margutti
Simona
S
D009682:Magnetic Resonance Spectroscopy; D010080:Oxazoles / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*
D010080:Oxazoles; D047428:Protein Kinase Inhibitors; D048051:p38 Mitogen-Activated Protein Kinases