Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase.
The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters.
Atoui
Ali
A
Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA.
Bao
Dapeng
D
Kaur
Navgeet
N
Grayburn
W Scott
WS
Calvo
Ana M
AM
D001233:Aspergillus nidulans / Q000378:metabolism*; D001688:Biological Products / Q000096:biosynthesis*; D017353:Gene Deletion; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D007211:Indoles / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D010406:Penicillins / Q000096:biosynthesis; D010675:Pheromones / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013241:Sterigmatocystin / Q000096:biosynthesis
D001688:Biological Products; D007211:Indoles; D010406:Penicillins; D010675:Pheromones; C496935:terrequinone A; D013241:Sterigmatocystin; D020928:Mitogen-Activated Protein Kinases