[Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions].
Experiments on white mice under the model immobilization stress condition showed that a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity, and normalization of the cortisole level. This effect is explained by a complex pharmacological action of all factors on the immune and endocrine mechanisms of the stress pathogenesis.
Podsevatkin
V G
VG
Kiriukhina
S V
SV
Podsevatkin
D V
DV
Podsevatkina
S V
SV
Blinov
D S
DS
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003975:Diazepam / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D006931:Hyperbaric Oxygenation; D007103:Immobilization; D007155:Immunologic Factors / Q000494:pharmacology; D008297:Male; D051379:Mice; D010847:Picolines / Q000494:pharmacology*; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology
D014151:Anti-Anxiety Agents; D000975:Antioxidants; D004151:Dipeptides; D007155:Immunologic Factors; D010847:Picolines; C060736:thymogen; C070020:emoxypine succinate; D003975:Diazepam; D006854:Hydrocortisone