Effect of a lactose-free milk formula supplemented with bifidobacteria and streptococci on the recovery from acute diarrhoea.
Probiotics have been proposed for the management and prevention of acute diarrhoea in infants. A double-blind, randomised, placebo controlled study was carried out in 224 Chinese infants 6 to 36 months of age with severe acute diarrhoea and free from moderate or severe malnutrition. After oral or parenteral rehydration, they were allocated to one of three groups: a lactose-free formula (Control); the same formula but with viable 10(8)CFU B. lactis Bb12 and 5x10(7)CFU St. thermophilus TH4 per gram of powder and, the same formula with the same microorganisms, but with 10(9)CFU/g and 5x10(8)CFU, respectively. Anthropometric parameters, duration of the diarrhoea and rotavirus shedding were evaluated. Eighty seven percent of the episodes were associated with rotavirus infection. The duration of the diarrhoea was not influenced by the intake of probiotics. However, a decrease of rotavirus shedding was observed in infants fed the formula with 10(9) Bb12/g, a finding of probable epidemiological importance in the transmission of this agent.
Mao
Meng
M
School of Medicine, the Second University Hospital, Sichuan University, Chengdu, China.
Yu
Tao
T
Xiong
Ying
Y
Wang
Zhiling
Z
Liu
Hanmin
H
Gotteland
Martin
M
Brunser
Oscar
O
D000208:Acute Disease; D001644:Bifidobacterium / Q000502:physiology*; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003967:Diarrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007785:Lactose / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*; D012400:Rotavirus Infections / Q000188:drug therapy* / Q000635:transmission; D013291:Streptococcus / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome; D017201:Virus Shedding / Q000187:drug effects
D007785:Lactose