title: [Protective effect of 3-hydroxypyridine derivatives in extreme conditions].
abstract: The paper presents the results of experimental and clinical testing of 3-hydroxypyridine derivatives (emoxipin, mexidol and new compounds) various extreme conditions (hypoxia, hyper- and hypothermia, vibration, hypokinesia, ionizing and nonionizing radiation and others). Analysis of the results led to the conclusion that 3-hydroxipiridine derivatives are a group of compounds worthy of further in-depth investigations in a broad range of extreme conditions in order to assess their potential use in development of new medical protectors of humans and animals facing extreme factors of various nature.
authors: V V
authors: VV
authors: Iasnetsov
mesh_terms: D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects*; D001930:Brain Injuries / Q000188:drug therapy*; D006801:Humans; D007035:Hypothermia / Q000188:drug therapy*; D000860:Hypoxia / Q000188:drug therapy / Q000517:prevention & control*; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; C070020:emoxypine succinate; C023500:3-hydroxypyridine