title: DNA-binding properties studies and spectra of a novel Cu(II) complex with a new coumarin derivative.
abstract: A new coumarin derivative (8-methylcoumaro-4a,10a-pyrone-3-carbaldehyde benzoyl hydrazone) ligand and its novel Cu(II) complex have been synthesized and characterized on the basis of elemental analyses, molar conductivities, (1)H-NMR, IR spectra, UV-visible spectroscopy and thermal analyses. In addition, the interactions of the Cu(II) complex and the ligand with calf-thymus DNA were investigated by spectrometric titrations, ethidium bromide displacement experiments and viscosity measurements. It was found that both the two compounds, specially the Cu(II) complex, strongly bind with calf-thymus DNA, presumably via an intercalation mechanism.
authors: College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou University, PR China.
authors: Gao-Fei
authors: GF
authors: Qi
authors: Zheng-Yin
authors: ZY
authors: Yang
authors: Dong-Dong
authors: DD
authors: Qin
authors: Bao-Dui
authors: BD
authors: Wang
authors: Tian-Rong
authors: TR
authors: Li
mesh_terms: D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D004996:Ethidium / Q000737:chemistry; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
chemical_list: D003374:Coumarins; D007364:Intercalating Agents; D008024:Ligands; C529357:methylcoumaro-4a,10a-pyrone-3-carbaldehyde; D003300:Copper; D004247:DNA; D004996:Ethidium