[New progress in crystallization technology of membrane protein and introduction of pharamaceutical innovation value chain].
We have recently established a Pharamaceutical Innovation Value Chain in collaboration with the SOSHO project (http://www.so-sho.jp) and BioGrid Project (http://www.biogrid.jp/) to accelerate new drug development. The SOSHO project provides novel crystallization technology with laser-irradiation and stirring growth methods, and the BioGrid Project is developing the software necessary for the in silico screening of promising drugs and the simulation of biological responses to proteins. In this paper, we report the recent research work on the crystallization of membrane proteins and the development of a method for in silico drug discovery.
Inoue
Tsuyoshi
T
Graduate School of Engineering Osaka University, Yamada-Oka, Suita City, Japan. inouet@chem.eng.osaka-u.ac.jp
Adachi
Hiroaki
H
Murakami
Satoshi
S
Takano
Kazufumi
K
Matsumura
Hiroyoshi
H
Mori
Yusuke
Y
Fukunishi
Yoshifumi
Y
Nakamura
Haruki
H
Kinoshita
Takayoshi
T
Nakanishi
Isao
I
Okuno
Yasushi
Y
Minakata
Satoshi
S
Shimojo
Shinji
S
Sakata
Tsuneaki
T
D000818:Animals; D003460:Crystallization / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D007834:Lasers; D008565:Membrane Proteins; D012984:Software; D013678:Technology, Pharmaceutical / Q000379:methods*
D008565:Membrane Proteins