title: Evaluation of service mammography screening impact in Italy. The contribution of hazard analysis.
abstract: 12,987 invasive breast cancer cases were diagnosed in women aged 50-69 upto the year 2001 in nine Italian areas where a screening programme was active. Cases were followed up in 2005 for a total of 1921 breast cancer failures. The 10-year survival rates were 85.3% for the invited group against 75.6% for the non-invited. A time dependent analysis was performed using 5-year intervals. Crude hazard ratios for the invited group in comparison to the not invited group were 0.52 and 0.64 respectively in the (0-5) year and [5-10] year time windows. Hazard ratio adjusted for tumour characteristics was 0.96 in the [5-10] year time window, suggesting minimal or any length bias. Consistent with the results of randomised trials, these analyses of service screening data document a mortality reduction of 36% at 5-10 years after diagnosis.
authors: Clinical and Descriptive Epidemiology Unit, CSPO, Research Institute of the Tuscany Region, Firenze, Italy. e.paci@cspo.it
authors: Eugenio
authors: E
authors: Paci
authors: Enzo
authors: E
authors: Coviello
authors: Guido
authors: G
authors: Miccinesi
authors: Donella
authors: D
authors: Puliti
authors: Laura
authors: L
authors: Cortesi
authors: Vincenzo
authors: V
authors: De Lisi
authors: Stefano
authors: S
authors: Ferretti
authors: Lucia
authors: L
authors: Mangone
authors: Vincenza
authors: V
authors: Perlangeli
authors: Antonio
authors: A
authors: Ponti
authors: Alessandra
authors: A
authors: Ravaioli
authors: Priscilla Sassoli
authors: PS
authors: de' Bianchi
authors: Nereo
authors: N
authors: Segnan
authors: Fabrizio
authors: F
authors: Stracci
authors: Rosario
authors: R
authors: Tumino
authors: Maurizio
authors: M
authors: Zarcone
authors: Manuel
authors: M
authors: Zorzi
authors: Marco
authors: M
authors: Zappa
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000517:prevention & control; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008327:Mammography / Q000401:mortality / Q000592:standards*; D008403:Mass Screening / Q000379:methods / Q000401:mortality; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D016019:Survival Analysis