title: Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions.
abstract: BACKGROUND
  Endoscopic tri-modal imaging (ETMI) incorporates white light endoscopy (WLE), autofluorescence imaging (AFI) and narrow-band imaging (NBI).
  
  
  OBJECTIVE
  To assess the value of ETMI for the detection and classification of neoplasia in patients with longstanding ulcerative colitis.
  
  
  METHODS
  Randomised comparative trial of tandem colonoscopies.
  
  
  METHODS
  Academic Medical Centre Amsterdam, Netherlands.
  
  
  METHODS
  Fifty patients with ulcerative colitis underwent surveillance colonoscopy with ETMI. Each colonic segment was inspected twice, once with AFI and once with WLE, in random order. All detected lesions were inspected by NBI for Kudo pit pattern analysis and additional random biopsies were taken.
  
  
  METHODS
  Neoplasia miss-rates of AFI and WLE, and accuracy of the Kudo classification by NBI.
  
  
  RESULTS
  Among patients assigned to inspection with AFI first (n = 25), 10 neoplastic lesions were primarily detected. Subsequent WLE detected no additional neoplasia. Among patients examined with WLE first (n = 25), three neoplastic lesions were detected; subsequent inspection with AFI added three neoplastic lesions. Neoplasia miss-rates for AFI and WLE were 0% and 50% (p = 0.036). The Kudo classification by NBI had a sensitivity and specificity of 75% and 81%; however, all neoplasia was coloured purple on AFI (sensitivity 100%). No additional patients with neoplasia were detected by random biopsies.
  
  
  CONCLUSIONS
  Autofluorescence imaging improves the detection of neoplasia in patients with ulcerative colitis and decreases the yield of random biopsies. Pit pattern analysis by NBI has a moderate accuracy for the prediction of histology, whereas AFI colour appears valuable in excluding the presence of neoplasia.
  
  
  BACKGROUND
  ISRCTN05272746.
authors: Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
authors: F J C
authors: FJ
authors: van den Broek
authors: P
authors: P
authors: Fockens
authors: S
authors: S
authors: van Eeden
authors: J B
authors: JB
authors: Reitsma
authors: J C H
authors: JC
authors: Hardwick
authors: P C F
authors: PC
authors: Stokkers
authors: E
authors: E
authors: Dekker
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000150:complications*; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000209:etiology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008856:Microscopy, Fluorescence / Q000379:methods; D008875:Middle Aged; D011159:Population Surveillance