Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs.
Bleomycin and Interleukin 12 have been used clinically to treat tumors; however, the co-administration of Bleomycin and Interleukin 12 followed by electroporation has not been tested clinically. In this study, dogs with spontaneous head and neck tumors were treated with one co-administration of Bleomycin and Interleukin 12 plasmid DNA followed by electroporation. The regression of the recurrent papillary tumor and the adjacent metastatic bone tumor was analyzed by multiple CT scans. The papillary tumor was completely eradicated in less than 2 weeks, and the bone tumor was not visible 23 weeks after the administration.
Cutrera
Jeffry
J
Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Torrero
Marina
M
Shiomitsu
Keijiro
K
Mauldin
Neal
N
Li
Shulin
S
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004274:DNA, Recombinant / Q000008:administration & dosage / Q000235:genetics; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D004285:Dogs; D053672:Electrochemotherapy / Q000379:methods / Q000662:veterinary*; D015316:Genetic Therapy / Q000379:methods / Q000662:veterinary*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy / Q000662:veterinary*; D018664:Interleukin-12 / Q000235:genetics* / Q000627:therapeutic use; D010957:Plasmids / Q000008:administration & dosage / Q000235:genetics; D011994:Recombinant Proteins / Q000235:genetics / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000903:Antibiotics, Antineoplastic; D004274:DNA, Recombinant; D011994:Recombinant Proteins; D001761:Bleomycin; D018664:Interleukin-12