Cyclooxygenase-2 overexpression in ovarian endometriomas is associated with higher risk of recurrence.
Cyclooxegenase-2 expression was evaluated by immunohistochemistry in endometrioma tissue samples taken from 109 patients, of whom 53 had recurrence by 30 months after surgery and 56 did not. Cyclooxegenase-2 overexpression, along with previous medical treatment of endometriosis and the presence of adhesion, is predictive of recurrence of ovarian endometrioma within 30 months after surgery, with a resultant sensitivity of 72.5% and a specificity of 72.4%, suggesting that there are intrinsic and identifiable biomarkers that confer recurrence risk.
Yuan
Lei
L
Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
Shen
Fanghua
F
Lu
Yuan
Y
Liu
Xishi
X
Guo
Sun-Wei
SW
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004715:Endometriosis / Q000201:enzymology* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000201:enzymology* / Q000453:epidemiology* / Q000473:pathology; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D051546:Cyclooxygenase 2