title: Synonym set extraction from the biomedical literature by lexical pattern discovery.
abstract: BACKGROUND
  Although there are a large number of thesauri for the biomedical domain many of them lack coverage in terms and their variant forms. Automatic thesaurus construction based on patterns was first suggested by Hearst 1, but it is still not clear how to automatically construct such patterns for different semantic relations and domains. In particular it is not certain which patterns are useful for capturing synonymy. The assumption of extant resources such as parsers is also a limiting factor for many languages, so it is desirable to find patterns that do not use syntactical analysis. Finally to give a more consistent and applicable result it is desirable to use these patterns to form synonym sets in a sound way.
  
  
  RESULTS
  We present a method that automatically generates regular expression patterns by expanding seed patterns in a heuristic search and then develops a feature vector based on the occurrence of term pairs in each developed pattern. This allows for a binary classifications of term pairs as synonymous or non-synonymous. We then model this result as a probability graph to find synonym sets, which is equivalent to the well-studied problem of finding an optimal set cover. We achieved 73.2% precision and 29.7% recall by our method, out-performing hand-made resources such as MeSH and Wikipedia.
  
  
  CONCLUSIONS
  We conclude that automatic methods can play a practical role in developing new thesauri or expanding on existing ones, and this can be done with only a small amount of training data and no need for resources such as parsers. We also concluded that the accuracy can be improved by grouping into synonym sets.
authors: National Institute of Informatics, Hitotsubashi 2-1-2, Chiyoda-ku, Tokyo, 101-8430, Japan. jmccrae@nii.ac.jp
authors: John
authors: J
authors: McCrae
authors: Nigel
authors: N
authors: Collier
mesh_terms: D001185:Artificial Intelligence; D019295:Computational Biology / Q000379:methods; D003628:Database Management Systems; D004014:Dictionaries as Topic; D016247:Information Storage and Retrieval / Q000379:methods*; D009323:Natural Language Processing; D010363:Pattern Recognition, Automated / Q000379:methods; D010506:Periodicals as Topic; D012660:Semantics; D018875:Vocabulary, Controlled