title: Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis.
abstract: OBJECTIVE
  To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA.
  
  
  METHODS
  This is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F,10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA).
  
  
  RESULTS
  Median adjusted height (AHt) SDS was -0.3 (-2.2 to 1.6). Serum ALS SDS (median -1.3, range -2.7 to -0.6) was reduced compared with serum IGFBP-3 SDS (median -0.5, range -7.7 to 2.3) and IGF-1 SDS (median -0.2, range -0.5 to 0.5). Log serum IL5 (95% CI -3.25, -0.81) and log serum IL15 (95% CI -9.58, -4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS.
  
  
  CONCLUSIONS
  Children with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.
authors: Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, United Kingdom.
authors: S C
authors: SC
authors: Wong
authors: Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, United Kingdom; Bone Biology Group, Roslin Institute, Roslin, United Kingdom.
authors: V E
authors: VE
authors: MacRae
authors: Centre for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom.
authors: J A
authors: JA
authors: Gracie
authors: Centre for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom.
authors: I B
authors: IB
authors: McInnes
authors: Department of Child Health, University of Glasgow, Glasgow, United Kingdom.
authors: P
authors: P
authors: Galea
authors: Department of Child Health, University of Glasgow, Glasgow, United Kingdom.
authors: J
authors: J
authors: Gardner-Medwin
authors: Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, United Kingdom.
authors: S F
authors: SF
authors: Ahmed
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood* / Q000276:immunology; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006130:Growth Disorders / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015848:Interleukin-5 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011446:Prospective Studies; D011627:Puberty
chemical_list: D016207:Cytokines; C508599:IL5 protein, human; C508600:IL6 protein, human; D018969:Insulin-Like Growth Factor Binding Proteins; D015848:Interleukin-5; D015850:Interleukin-6; D007334:Insulin-Like Growth Factor I