title: A biocompatible polysaccharide hydrogel-embedded polypropylene mesh for enhanced tissue integration in rats.
abstract: Prosthetic materials are largely used in surgery and tissue engineering. However, many postoperative complications are due to poor integration of the materials, which delays the healing process. The objective of our study was to develop a synthetic scaffold that, according to histopathological and biomechanical criteria, would achieve both tolerance and efficiency. In this study, we evaluated the effect of intramuscular and subcutaneous implantation of a new hybrid mesh (HM) in rats. This HM was composed of clinical grade polypropylene mesh embedded in a polysaccharide hydrogel. Histological and biomechanical studies on the polysaccharide gel alone and on HM were performed 15 and 30 days after implantation, and then compared with two clinically used materials, porcine decellularized small intestinal submucosa and a polypropylene mesh. Results showed that the incorporation of a polypropylene mesh within the polysaccharide hydrogel led to the absence of adverse effects and better tissue organization. Thus, this new synthetic biocompatible HM with suitable properties for tissue repair appears to be a promising material for clinical applications.
authors: INSERM U 698, CHU Xavier Bichat, Bât. Inserm, Paris, France.
authors: Aicha
authors: A
authors: Abed
authors: Bruno
authors: B
authors: Deval
authors: Nabila
authors: N
authors: Assoul
authors: Isabelle
authors: I
authors: Bataille
authors: Patrick
authors: P
authors: Portes
authors: Liliane
authors: L
authors: Louedec
authors: Dominique
authors: D
authors: Henin
authors: Didier
authors: D
authors: Letourneur
authors: Anne
authors: A
authors: Meddahi-Pellé
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D002448:Cell Adhesion; D019245:Compressive Strength; D003911:Dextrans; D005936:Glucans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis*; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing / Q000295:instrumentation; D009132:Muscles; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D040521:Subcutaneous Tissue; D013526:Surgical Mesh; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D005936:Glucans; D011126:Polypropylenes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C009109:pullulan