[Role of PGE2 in bone metastatic cancer].
Prostaglandin E(2) is a crucial mediator to maintain physiological homeostasis and several disease progression. In this article, we summarized the roles of PGE(2) in bone resorptive metastatic model using B16 melanoma. An antagonist of EP4, a receptor subtype for PGE(2), suppressed RANKL expression in osteoblast and following osteoclast formation that was induced by B16, suggesting cancer induced bone resorption mediate PGE(2) production in host osteoblast is a key role of cancer metastasis to bone.
Inada
Masaki
M
Tokyo University of Agriculture and Technology, Department of Biotechnology and Life Science.
Miyaura
Chisato
C
D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology* / Q000556:secondary*; D001862:Bone Resorption / Q000209:etiology; D015232:Dinoprostone / Q000096:biosynthesis / Q000502:physiology*; D018450:Disease Progression; D006706:Homeostasis; D006801:Humans; D008546:Melanoma, Experimental; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts; D053245:RANK Ligand / Q000378:metabolism; D018078:Receptors, Prostaglandin E / Q000037:antagonists & inhibitors; D058309:Receptors, Prostaglandin E, EP4 Subtype
C545650:PTGER4 protein, human; D053245:RANK Ligand; D018078:Receptors, Prostaglandin E; D058309:Receptors, Prostaglandin E, EP4 Subtype; D015232:Dinoprostone