title: Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization.
abstract: Precursor systems of liquid crystalline phase were prepared using the surfactant PPG-5-Ceteth-20, isopropyl myristate, and water; gelatin microparticles containing propolis were then added into these systems. Homogeneity of dispersion, the in-system microparticle morphology, and sedimentation behavior of each formulation were evaluated. The rheological and mechanical properties (hardness, compressibility, and adhesiveness), the work of syringing, and the propolis release profile were also evaluated. All the formulations exhibited pseudoplastic flow and thixotropy, and they displayed storage modulus, loss modulus, dynamic viscosity, and loss tangent that depended on temperature, frequency, and composition. Mechanical properties varied significantly among the formulations being affected by changes in the composition and temperature. Raising the concentration of surfactant and adding propolis microparticles significantly decreased the work of syringing. The drug release was non-Fickian (anomalous) and there was no significant difference between the tested systems in the times required for 10%, 30%, and 50% release of the initial drug loading.
authors: Postgraduation Programme in Pharmaceutical Sciences, Pharmaceutical School of Ribeirao Preto, University of São Paulo, Brazil. bruschiml@yahoo.com.br
authors: Marcos Luciano
authors: ML
authors: Bruschi
authors: Osvaldo
authors: O
authors: de Freitas
authors: Elza Helena Guimarã Es
authors: EH
authors: Lara
authors: Heitor
authors: H
authors: Panzeri
authors: Maria Palmira Daflon
authors: MP
authors: Gremião
authors: David Simon
authors: DS
authors: Jones
mesh_terms: D000268:Adhesiveness; D000890:Anti-Infective Agents / Q000737:chemistry*; D016503:Drug Delivery Systems; D005233:Fatty Alcohols / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D006244:Hardness; D050866:Liquid Crystals / Q000737:chemistry; D009226:Myristates / Q000737:chemistry; D010510:Periodontal Diseases / Q000188:drug therapy; D011429:Propolis / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D012212:Rheology; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D005233:Fatty Alcohols; D009226:Myristates; D011409:Propylene Glycols; D013501:Surface-Active Agents; C008205:isopropyl myristate; D005780:Gelatin; D011429:Propolis; C005031:cetyl alcohol