HER2/neu DNA vaccination for breast tumors.
Several studies of DNA vaccination against HER2/neu showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumors. The DNA delivery system plays a crucial role in the success of DNA vaccination. In particular, our studies of DNA vaccination against HER2/neu tumor antigen showed that intramuscular injection of the vaccine followed by electroporation elicits an optimal protection against the development of spontaneous HER2/neu- tumors occurring in transgenic mice.
Smorlesi
Arianna
A
Immunology Center, INRCA Research Department, Ancona, Italy.
Papalini
Francesca
F
Pierpaoli
Sara
S
Provinciali
Mauro
M
D000818:Animals; D000912:Antibodies, Neoplasm / Q000097:blood; D045744:Cell Line, Tumor; D016207:Cytokines / Q000378:metabolism; D053672:Electrochemotherapy / Q000379:methods*; D005260:Female; D018734:Genes, erbB-2; D007111:Immunity, Cellular; D007273:Injections, Intramuscular; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008822:Mice, Transgenic; D010957:Plasmids / Q000008:administration & dosage / Q000235:genetics; D051381:Rats; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000235:genetics*
D000912:Antibodies, Neoplasm; D016207:Cytokines; D019444:Vaccines, DNA