title: Healing of ischaemic tissue lesions after infrainguinal bypass surgery for critical leg ischaemia.
abstract: OBJECTIVE
  To evaluate healing time of ischaemic tissue lesions, limb salvage and survival in patients suffering from critical limb ischaemia (CLI) with tissue loss.
  
  
  METHODS
  Prospective single centre cohort study.
  
  
  METHODS
  Consecutive patients with CLI and tissue loss (Fontaine IV) (148 patients, 150 limbs) were followed prospectively for 1 year after infrainguinal bypass. Healing time of tissue lesions, graft patency, limb salvage, survival rates and the overall need for any type of surgical and endovascular procedure were analysed. Patient comorbidities were assessed by uni- and multivariate analysis to determine risk factors for adverse outcome.
  
  
  RESULTS
  Complete tissue healing, including healing of ischaemic tissue lesions and surgical wounds, at 6 and 12 months after the infrainguinal bypass were respectively 40% and 75%. The median time to complete tissue healing was 190 days. Diabetes was the only significant risk factor which delayed tissue healing. Overall patency, limb salvage, survival and amputation-free survival rates were respectively at 12 months 80%, 81%, 73% and 63%. The clinically important endpoint amputation-free survival with completely healed wounds was attained in 50% of patients at 1 year.
  
  
  CONCLUSIONS
  Complete healing of ischemic tissue lesions is slow even after a successful infrainguinal bypass.
authors: Department of Vascular Surgery, Helsinki University Central Hospital, Finland. maria.soderstrom@hus.fi
authors: M
authors: M
authors: Söderström
authors: E
authors: E
authors: Arvela
authors: A
authors: A
authors: Albäck
authors: P-S
authors: PS
authors: Aho
authors: M
authors: M
authors: Lepäntalo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D016638:Critical Illness; D048909:Diabetes Complications / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007511:Ischemia / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D053208:Kaplan-Meier Estimate; D007866:Leg / Q000098:blood supply*; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012086:Reoperation; D012501:Saphenous Vein / Q000637:transplantation*; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency; D014945:Wound Healing