title: Social support and enhanced suppression of adrenocorticotropic hormone and cortisol responses to hypothalamic-pituitary-adrenal function and thyrotropin-releasing hormone tests in patients with major depressive disorder.
abstract: The results of the thyrotropin-releasing hormone (TRH) stimulation test and the combined dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are believed to correlate with social support status in patients with major depressive disorder. We studied 41 consecutive patients hospitalized for major depressive disorder and tested their responses to DEX/CRH and TRH on hospital days 4-7. DeltaMAX TSH and DeltaMAX cortisol were measured. Multiple regression analysis found that social support questionnaire (SSQ-A) and SSQ-B scores were significantly related to DeltaMAX cortisol and DeltaMAX TSH, respectively, at the time of admission. Social support might contribute partially to the TRH and DEX/CRH test results in patients with major depressive disorder.
authors: Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Oita 879-5593, Japan.
authors: Jusen
authors: J
authors: Tsuru
authors: Jotaro
authors: J
authors: Akiyoshi
authors: Yoshihiro
authors: Y
authors: Tanaka
authors: Hirotaka
authors: H
authors: Matsushita
authors: Hiroaki
authors: H
authors: Hanada
authors: Kensuke
authors: K
authors: Kodama
authors: Takatoshi
authors: T
authors: Hikichi
authors: Hirochika
authors: H
authors: Ohgami
authors: Takashi
authors: T
authors: Tsutsumi
authors: Koichi
authors: K
authors: Isogawa
authors: Haruo
authors: H
authors: Nagayama
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003346:Corticotropin-Releasing Hormone; D003865:Major Depressive Disorder / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism*; D011446:Prospective Studies; D012044:Regression Analysis; D012189:Retrospective Studies; D012944:Social Support; D011795:Surveys and Questionnaires
chemical_list: D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone