title: Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury.
abstract: OBJECTIVE
  Prolonged erythrocyte storage time might reduce the efficacy of transfusion. In this study, the effects of transfusion of erythrocytes with four different storage periods (<10 days, n = 18; 10-14 days, n = 15; 15-19 days, n = 17; and >19 days, n = 16 patients) on brain tissue oxygen tension (PtiO2) in stable male patients with severe traumatic brain injury were investigated during a 24-hr follow-up period.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  Neurotrauma critical care unit of a university hospital.
  
  
  METHODS
  Sixty-six male, nonbleeding, hemodynamically stable anemic patients (hemoglobin <95 g/L) with Glasgow Coma Scale score <9.
  
  
  METHODS
  None.
  
  
  RESULTS
  PtiO2, cerebral perfusion pressure, mean arterial pressure, intracranial pressure, peripheral oxygen saturation, CO2 pressure at the end of expiration, and intracerebral temperature were recorded in all patients at baseline, immediately after the completion of transfusion, and 1, 2, 3, 4, 5, 6, 12, and 24 hrs posttransfusion. All four groups were homogeneous with respect to multiple baseline variables, except for storage time of transfused erythrocytes (p < .0001). There was a significant short-lasting (3-4 hrs) increase in PtiO2 values after transfusion of erythrocytes stored for <10 days, 10-14 days, or 15-19 days, compared with those at baseline. In contrast, no significant changes in PtiO2 were observed after transfusion of erythrocytes stored >19 days.
  
  
  CONCLUSIONS
  Transfusion of erythrocytes increased cerebral oxygenation in patients with severe traumatic brain injury, except in those transfused with erythrocytes stored >19 days.
authors: Neurotrauma Critical Care, Hospital Universitario Virgen del Rocío, Seville, Spain. sramon@cica.es
authors: Santiago Ramón
authors: SR
authors: Leal-Noval
authors: Manuel
authors: M
authors: Muñoz-Gómez
authors: Victoria
authors: V
authors: Arellano-Orden
authors: Antonio
authors: A
authors: Marín-Caballos
authors: Rosario
authors: R
authors: Amaya-Villar
authors: Ana
authors: A
authors: Marín
authors: Antonio
authors: A
authors: Puppo-Moreno
authors: Carmen
authors: C
authors: Ferrándiz-Millón
authors: Juan Manuel
authors: JM
authors: Flores-Cordero
authors: Francisco
authors: F
authors: Murillo-Cabezas
mesh_terms: D000328:Adult; D001793:Blood Preservation; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D017707:Erythrocyte Transfusion; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D013997:Time Factors; D014193:Trauma Centers
chemical_list: D010100:Oxygen