title: Tetrazole based amides as growth hormone secretagogues.
abstract: A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
authors: Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543-5400, USA. James.Li@bms.com
authors: James J
authors: JJ
authors: Li
authors: Haixia
authors: H
authors: Wang
authors: Jun
authors: J
authors: Li
authors: Fucheng
authors: F
authors: Qu
authors: Stephen G
authors: SG
authors: Swartz
authors: Andrés S
authors: AS
authors: Hernández
authors: Scott A
authors: SA
authors: Biller
authors: Jeffrey A
authors: JA
authors: Robl
authors: Joseph A
authors: JA
authors: Tino
authors: Dorothy
authors: D
authors: Slusarchyk
authors: Ramakrishna
authors: R
authors: Seethala
authors: Paul
authors: P
authors: Sleph
authors: Mujing
authors: M
authors: Yan
authors: Gary
authors: G
authors: Grover
authors: Neil
authors: N
authors: Flynn
authors: Brian J
authors: BJ
authors: Murphy
authors: David
authors: D
authors: Gordon
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D005910:Glioma / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D000577:Amides; D013777:Tetrazoles; C045574:1H-tetrazole; D013006:Growth Hormone