Cerebellar ataxia in non-paraneoplastic Lambert-Eaton myasthenic syndrome.
Lambert-Eaton myasthenic syndrome (LEMS) is an immune-mediated disorder of the neuromuscular junction that rarely is associated with cerebellar ataxia (CA). We describe two patients with non-paraneoplastic LEMS associated with CA who showed high levels of anti-P/Q-type voltage-gated calcium channels antibodies in the serum and cerebrospinal fluid, and reduced CMAP with increment after brief maximum voluntary contraction in electrophysiological studies. We suggest that LEMS should be considered in the differential diagnosis of patients with CA.
Lorenzoni
Paulo J
PJ
Department of Internal Medicine, Universidade Federal do Paraná, Curitiba, Brazil.
Scola
Rosana H
RH
Lang
Bethan
B
Kay
Claudia S K
CS
Teive
Helio A G
HA
Kowacs
Pedro A
PA
Werneck
Lineu C
LC
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000906:Antibodies / Q000097:blood; D015220:Calcium Channels / Q000276:immunology; D002524:Cerebellar Ataxia / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D015624:Lambert-Eaton Myasthenic Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000150:complications
D000906:Antibodies; D015220:Calcium Channels; D016756:Immunoglobulins, Intravenous