title: Peripheral blood gamma-delta T cells in advanced-stage cancer patients.
abstract: Gamma-delta T (gammadelta T) cells form a subgroup which has been reported to play a role in both natural and acquired immunity. Their levels have been found to increase in some tumour tissues. The aim of this study was to investigate the ratio of gammadelta T cells to all T cells in the peripheral blood of advanced-stage cancer patients; the level of gammadelta T cells expressing the Vdelta2-T-cell receptor (TCR) chain; NKG2D receptor expression; and apoptotic (Annexin-V) gammadelta T-cell levels. Twenty patients with advanced-stage cancer and 13 healthy controls were included. No statistical differences were found between control and patient groups in terms of the gammadelta T/total T-cell ratio (P=0.53), the Vgamma2-TCR expressing gammadelta T-cell ratio (P=0.19) or the Annexin-V ratio (P=0.48). However, NKG2D expression in gammadelta T cells was significantly different between the control and patient groups (P=0.014). In summary it was shown that the levels of NKG2D receptors, which are responsible for the cytolytic effect of gammadelta T cells, were lower in cancer patients than in healthy adults. However, no significant differences were observed in the other parameters studied between groups.
authors: Department of Medical Oncology, Gulhane Military Medical Academy Haydarpaşa Teaching Hospital, 34668, Uskudar, Istanbul, Turkey. ogzblg@yahoo.com
authors: Oguz
authors: O
authors: Bilgi
authors: Bülent
authors: B
authors: Karagoz
authors: Orhan
authors: O
authors: Turken
authors: E Gokhan
authors: EG
authors: Kandemir
authors: Ahmet
authors: A
authors: Ozturk
authors: Mahmut
authors: M
authors: Gumus
authors: Mustafa
authors: M
authors: Yaylaci
mesh_terms: D000368:Aged; D017304:Annexin A5 / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000096:biosynthesis; D009369:Neoplasms / Q000097:blood* / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D017304:Annexin A5; D055655:NK Cell Lectin-Like Receptor Subfamily K; D016692:Receptors, Antigen, T-Cell, gamma-delta