title: How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center.
abstract: BACKGROUND
  Ampullary adenomas are increasingly being recognized, particularly in patients with familial adenomatous polyposis. A capsule endoscopy (CE) is routinely recommended for surveillance of small-intestinal polyposis. Performance characteristics of CE for the detection of periampullary lesions are unclear.
  
  
  OBJECTIVE
  To evaluate the ability of CE to detect the major duodenal papilla.
  
  
  METHODS
  A total of 146 consecutive CE studies were reviewed by 2 CE gastroenterologists at 5 frames per second. Primary outcome was visualization of the major duodenal papilla. Discrepancies were reviewed by 5 CE gastroenterologists.
  
  
  METHODS
  A tertiary-referral center.
  
  
  METHODS
  The ability of CE to detect the duodenal papilla.
  
  
  RESULTS
  Among 146 consecutive CE studies, 21 were excluded: capsule retention (3), patient age <18 years (6), duplicate study (8), and prior surgery disrupting duodenal anatomy (4). Of the remaining 125 studies, indications were the following: obscure GI bleeding (45.6%), iron deficiency anemia (19.2%), abdominal pain (17.6%), diarrhea (10.4%), and Crohn's disease (4.8%). In total, 13 major duodenal papillae were visualized. The median time of detection was 31 seconds after the first duodenal image. This translates to a CE sensitivity of 10.4% for detection of the major papilla.
  
  
  CONCLUSIONS
  Papilla position was not verified by an EGD.
  
  
  CONCLUSIONS
  CE has limited sensitivity to visualize the major papilla and lesions in the periampullary small intestine. Nondiagnostic CE studies must not be relied upon as proof that small-bowel lesions do not exist. Consideration should be given for an enteroscopy or side-viewing duodenoscopy in cases where significant clinical concern exists for unrecognized periampullary lesions. The current recommendations about surveillance for small-bowel polyposis should be revised.
authors: Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors: John O
authors: JO
authors: Clarke
authors: Samuel A
authors: SA
authors: Giday
authors: Priscilla
authors: P
authors: Magno
authors: Eun Ji
authors: EJ
authors: Shin
authors: Jonathan M
authors: JM
authors: Buscaglia
authors: Sanjay B
authors: SB
authors: Jagannath
authors: Gerard E
authors: GE
authors: Mullin
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000473:pathology*; D000704:Analysis of Variance; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis; D053704:Capsule Endoscopy / Q000379:methods*; D015331:Cohort Studies; D003424:Crohn Disease / Q000175:diagnosis; D005069:Evaluation Studies as Topic; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D012680:Sensitivity and Specificity