title: Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1.
abstract: Azeotropic reflux chromatography (in which the eluent is continuously recycled by means of refluxing) was used to separate a mixture of spiroketal intermediates in the scale-up synthesis of spongistatin 1, leading to an improved separation and an approximately 35-fold reduction in the amount of solvent used.
authors: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW. mo263@cam.ac.uk
authors: Matthew
authors: M
authors: O'Brien
authors: Alejandro
authors: A
authors: Diéguez-Vázquez
authors: Day-Shin
authors: DS
authors: Hsu
authors: Helmut
authors: H
authors: Kraus
authors: Yukihito
authors: Y
authors: Sumino
authors: Steven V
authors: SV
authors: Ley