title: Correlation between rises in Chlamydia pneumoniae-specific antibodies, platelet activation and lipid peroxidation after percutaneous coronary intervention.
abstract: We recently showed that Chlamydia pneumoniae activates platelets in vitro, with an associated oxidation of low-density lipoproteins. The aim of this study was to investigate whether C. pneumoniae is released during percutaneous coronary intervention (PCI) and, thereby, causes platelet activation and lipid peroxidation. Seventy-three patients undergoing coronary angiography and following PCI or coronary artery bypass graft (CABG) and 57 controls were included in the study. C. pneumoniae antibodies, serotonin and lipid peroxidation were measured before and 24 h, 1 month and 6 months after angiography. The results show that serum C. pneumoniae IgA concentrations were significantly higher in patients than in the controls. Furthermore, in 38% of the C. pneumoniae IgG positive patients, the C. pneumoniae IgG concentration increased 1 month after PCI. The levels of C. pneumoniae IgG antibodies 1 month after PCI correlated with plasma-lipid peroxidation (r = 0.91, P < 0.0001) and platelet-derived serotonin (r = 0.62, P = 0.02). There was no elevation in the total serum IgG 1 month after PCI. In conclusion, the present results suggest that PCI treatment of coronary stenosis releases C. pneumoniae from the atherosclerotic lesions, which leads to platelet activation and lipid peroxidation.
authors: Department of Medicine and Health, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden. hanka@imv.liu.se
authors: H
authors: H
authors: Kälvegren
authors: J
authors: J
authors: Fridfeldt
authors: P
authors: P
authors: Garvin
authors: L
authors: L
authors: Wind
authors: P
authors: P
authors: Leanderson
authors: M
authors: M
authors: Kristenson
authors: E
authors: E
authors: Kihlström
authors: T
authors: T
authors: Bengtsson
authors: A
authors: A
authors: Richter
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D017073:Atherectomy / Q000009:adverse effects*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D001026:Coronary Artery Bypass / Q000009:adverse effects; D023921:Coronary Stenosis / Q000601:surgery*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015227:Lipid Peroxidation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D012701:Serotonin / Q000378:metabolism
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012701:Serotonin