Biological markers for axonal degeneration in CSF and blood of patients with the first event indicative for multiple sclerosis.
Axonal degeneration is now recognized as an important pathological feature of multiple sclerosis (MS). Acute axonal damage happens early in the disease course, and therefore early changes might occur in markers in body fluids, such as cerebrospinal fluid (CSF) and blood. In our study we investigated the relevance of serum and CSF markers for axonal damage in patients with clinically isolated syndrome indicative for MS. We measured the concentration of tau, phospho-tau, S100B, Amyloid beta and neuron specific enolase (NSE) in CSF and serum. Interestingly, the NSE concentration in CSF and serum was decreased in clinically isolated syndrome (CIS)-patients in comparison to the control group indicating reduced neuronal metabolic activity in the early stage of the disease. Concerning other biomarkers, we did not observe any changes in the concentrations between groups. Moreover, we did not detect any correlation between Expanded Disability Status Scale (EDSS) and the concentration of investigated proteins.
Hein Née Maier
Katharina
K
Neurologische Universitätsklinik, Robert-Koch-Str. 40, D-37075 Göttingen, Germany. kmaier@gwdg.de
Köhler
Anushka
A
Diem
Ricarda
R
Sättler
Muriel B
MB
Demmer
Iris
I
Lange
Peter
P
Bähr
Mathias
M
Otto
Markus
M
D000293:Adolescent; D000328:Adult; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism; D001369:Axons / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology*; D009410:Nerve Degeneration / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000032:analysis / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000378:metabolism; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis / Q000378:metabolism; D016875:tau Proteins / Q000032:analysis / Q000378:metabolism
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D016875:tau Proteins; D010751:Phosphopyruvate Hydratase