title: Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex.
abstract: Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF(6) revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 microM.
authors: Lehrstuhl für Anorganische Chemie I-Bioanorganische Chemie, Ruhr-Universität Bochum NC 3/74, Universitätsstrasse 150, D-44801 Bochum, Germany.
authors: Johanna
authors: J
authors: Niesel
authors: Antonio
authors: A
authors: Pinto
authors: Harmel W
authors: HW
authors: Peindy N'Dongo
authors: Klaus
authors: K
authors: Merz
authors: Ingo
authors: I
authors: Ott
authors: Ronald
authors: R
authors: Gust
authors: Ulrich
authors: U
authors: Schatzschneider
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D010777:Photochemistry; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D011720:Pyrazoles; D008345:Manganese; D002248:Carbon Monoxide