Muscle channelopathies.
In recent years the term CHANNELOPATHY has been adopted to describe neurological disorders caused by mutations in different ion channel genes. Myopathic channelopathies include two main groups: nondystrophic myotonias and periodic paralyses. This article reviews the clinical features, diagnostic approach, molecular causes, and management of patients with nondystrophic myotonias and periodic paralyses.
Saperstein
David S
DS
Phoenix Neurological Associates, 1331 North 7th Street, Suite 350, Phoenix, AZ 85006, USA. david.saperstein@gmail.com
D053447:Channelopathies / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004568:Electrodiagnosis; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D009154:Mutation / Q000235:genetics; D020967:Myotonic Disorders / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology*; D020513:Paralysis, Hyperkalemic Periodic / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology*
D007473:Ion Channels