title: Central diabetes insipidus following digestion Solanum indicum L. concentrated solution.
abstract: In Taiwan, Solanum indicum L. has been used in folk medicine for the treatment of inflammation, toothache, ascites, edema, and wound infection. The plant is rich in solanine, an alkaloidal glycoside. We report a 43-year-old man who developed polyuria and polydipsia after taking seven doses of concentrated solution of Solanum indicum L. over two weeks. A water deprivation test and a low serum antidiuretic hormone level helped to confirm a diagnosis of central diabetes insipidus. We suggest that excessive doses of Solanum indicum L. may cause central diabetes insipidus.
authors: Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors: Wen-Hung
authors: WH
authors: Huang
authors: Ching-Wei
authors: CW
authors: Hsu
authors: Ji-Tseng
authors: JT
authors: Fang
mesh_terms: D000328:Adult; D050034:Antidiuretic Agents / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000506:poisoning*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000506:poisoning; D011141:Polyuria / Q000139:chemically induced / Q000503:physiopathology; D012991:Solanaceous Alkaloids / Q000506:poisoning*; D012992:Solanine / Q000506:poisoning; D032322:Solanum / Q000737:chemistry*; D013624:Taiwan; D013894:Thirst / Q000187:drug effects
chemical_list: D050034:Antidiuretic Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012991:Solanaceous Alkaloids; D012992:Solanine; D003894:Deamino Arginine Vasopressin