title: A virtual look at Epstein-Barr virus infection: simulation mechanism.
abstract: Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
authors: Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
authors: M
authors: M
authors: Shapiro
authors: K A
authors: KA
authors: Duca
authors: K
authors: K
authors: Lee
authors: E
authors: E
authors: Delgado-Eckert
authors: J
authors: J
authors: Hawkins
authors: A S
authors: AS
authors: Jarrah
authors: R
authors: R
authors: Laubenbacher
authors: N F
authors: NF
authors: Polys
authors: V
authors: V
authors: Hadinoto
authors: D A
authors: DA
authors: Thorley-Lawson
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D049109:Cell Proliferation; D003198:Computer Simulation; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008221:Lymphoid Tissue / Q000382:microbiology; D018448:Models, Immunological; D017735:Virus Latency