title: Long-term experience with an anatomical anterograde approach to radical prostatectomy: results in terms of positive margin rate.
abstract: OBJECTIVE
  To evaluate the effect of an anterograde approach to radical retropubic prostatectomy (RRP) in terms of positive surgical margins (SM+).
  
  
  METHODS
  323 untreated patients underwent anterograde RRP for clinically localized prostate adenocarcinoma. Spearman coefficients, logistic univariate and multivariate analysis were used.
  
  
  RESULTS
  The incidence of SM+ was 14.9% and, in particular, this was 4.5% for apical, 9.0% for lateral, 0.9% for other sites, and 2.8% for multiple SM+. Upon univariate analysis, prostate-specific antigen (PSA; r = 0.2073, p = 0.0002), pathological stage (r = 0.3777, p < 0.0001), and seminal vesicle invasion (r = 0.1453, p = 0.0089) were found to be significantly associated with SM+. Upon multivariate analysis, only PSA (p = 0.0090) and pathological stage (p < 0.0001) were significantly and independently associated with SM+ occurrence.
  
  
  CONCLUSIONS
  In our experience, the anterograde approach to RRP is associated with low SM+ rates.
authors: Department Urology, University La Sapienza, Rome, Italy. sciarrajr@hotmail.com
authors: Alessandro
authors: A
authors: Sciarra
authors: Vincenzo
authors: V
authors: Gentile
authors: Anna
authors: A
authors: De Matteis
authors: Cristian
authors: C
authors: Dattilo
authors: Anna-Maria
authors: AM
authors: Autran Gomez
authors: Stefano
authors: S
authors: Salciccia
authors: Franco
authors: F
authors: Di Silverio
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors