Model of active transport of ions in cardiac cell.
A model of the active transport of ions in a cardiac muscle cell, which takes into account the active transport of Na(+), K(+), Ca(2+), Mg(2+), HCO(3)(-) and Cl(-) ions, has been constructed. The model allows independent calculations of the resting potential at the biomembrane and concentrations of basic ions (sodium, potassium, chlorine, magnesium and calcium) in a cell. For the analysis of transport processes in cardiac cell hierarchical algorithm "one ion-one transport system" was offered. The dependence of the resting potential on concentrations of the ions outside a cell has been established. It was shown, that ions of calcium and magnesium, despite their rather small concentration, play an essential role in maintenance of resting potential in cardiac cell. The calculated internal concentrations of ions are in good agreement with the corresponding experimental values.
Melkikh
A V
AV
Molecular Physics Chair, Ural State Technical University, 19 Mira Street, Yekaterinburg, Russia. mav@dpt.ustu.ru
Sutormina
M I
MI
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000502:physiology*; D008274:Magnesium / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000378:metabolism
D002712:Chlorides; D027982:Sodium-Bicarbonate Symporters; D019831:Sodium-Calcium Exchanger; D012964:Sodium; D000251:Adenosine Triphosphatases; C035123:magnesium sodium ATPase; D008274:Magnesium; D011188:Potassium; D002118:Calcium