Tandem Michael addition/ylide epoxidation for the synthesis of highly functionalized cyclohexadiene epoxide derivatives.
A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
Wang
Qing-Gang
QG
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 FengLin Lu, Shanghai 200032, China.
Deng
Xian-Ming
XM
Zhu
Ben-Hu
BH
Ye
Long-Wu
LW
Sun
Xiu-Li
XL
Li
Chuan-Ying
CY
Zhu
Chun-Yin
CY
Shen
Qi
Q
Tang
Yong
Y