[Study of the clinical heterogeneity of movement disorder in Parkinson disease].
OBJECTIVE
To investigate the clinical heterogeneity of movement disorder in Parkinson's disease (PD).


METHODS
Ninety-eight PD patients (68 males and 30 females) were divided into tremor-dominant PD (n=23), mixed subtype PD (n=29) and postural instability and gait disorder (PIGD)-dominant PD (n=46) groups, and the clinical heterogeneity of the movement function of the patients was compared.


RESULTS
The initial symptom of tremor-predominant PD was tremor, but patients with PIGD-dominant PD had rigidity and gait disorder as the initial symptoms, commonly compromising the left limb. The amended Hoehn-Yahr stage of tremor-dominant PD was significantly lower than that of the PIGD-dominant PD, while the score of Mini-Mental State Examination (MMSE) was significantly higher in the former. No statistical differences were found in the gender, course of disease and family history between the patients with different subtypes of PD.


CONCLUSIONS
There are significant differences in the initial and typical symptoms between tremor-dominant PD and PIGD-dominant PD.
Liu
Zhong-lin
ZL
Department of Neurology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. zhonglinliu126.com
Wang
Li-min
LM
Tao
En-xiang
EX
D000368:Aged; D005260:Female; D020233:Gait Disorders, Neurologic / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D010300:Parkinson Disease / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D004856:Postural Balance; D014202:Tremor / Q000473:pathology / Q000503:physiopathology