Regulation of alternative splicing by signal transduction pathways.
Alternative splicing is now recognized as a ubiquitous mechanism for controlling gene expression in a tissue-specific manner. A growing body of work from the past few years as begun to also highlight the existence of networks of signal-responsive alternative splicing in a variety of cell types. While the mechanisms by which signal transduction pathways influence the splicing machinery are relatively poorly understood, a few themes have begun to emerge for how extracellular stimuli can be communicated to specific RNA-binding proteins that control splice site selection by the spliceosome. This chapter describes our current understanding of signal-induced alternative splicing with an emphasis on these emerging themes and the likely directions for future research.
Lynch
Kristen W
KW
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75390-9038, USA. kristen.lynch@utsouthwestern.edu
D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D006801:Humans; D022821:RNA Splice Sites; D012333:RNA, Messenger / Q000235:genetics*; D015398:Signal Transduction; D017381:Spliceosomes / Q000502:physiology*
D022821:RNA Splice Sites; D012333:RNA, Messenger