Differences in hippocampal protein expression at 3 days, 3 weeks, and 3 months following induction of perinatal asphyxia in the rat.
Perinatal asphyxia (PA) was induced in Sprague-Dawley rats; pups were sacrificed 3 days, 3 weeks, and 3 months following the asphyctic insult, and hippocampal protein levels were determined by a gel-based proteomic method. Levels of antioxidant, metabolic, cytoskeleton, signaling, channel, proteasomal, chaperone, splicing, and synaptosomal proteins were dysregulated depending on the age following induction of PA. These proteins are proposed to be potential markers or pharmacological targets for PA.
Weitzdörfer
Rachel
R
Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18, 1090 Vienna, Austria.
Höger
Harald
H
Burda
Gudrun
G
Pollak
Arnold
A
Lubec
Gert
G
D000818:Animals; D001237:Asphyxia; D005260:Female; D005333:Fetus / Q000503:physiopathology*; D006624:Hippocampus / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D009419:Nerve Tissue Proteins