title: Biomechanical, microvascular, and cellular factors promote muscle and bone regeneration.
abstract: It is becoming clear that the long-term outcome of complex bone injuries benefits from approaches that selectively target biomechanical, vascular, and cellular pathways. The typically held view of either biological or mechanical aspects of healing is oversimplified and does not correspond to clinical reality. The fundamental mechanisms of soft tissue regeneration most likely hold the key to understanding healing response.
authors: Julius Wolff Institut, Center for Musculoskeletal Surgery and Berlin-Brandenburg Center for Regenerative Therapies Charité-Universitätsmedizin Berlin, Berlin, Germany. georg.duda@charite.de
authors: Georg N
authors: GN
authors: Duda
authors: William R
authors: WR
authors: Taylor
authors: Tobias
authors: T
authors: Winkler
authors: Georg
authors: G
authors: Matziolis
authors: Markus O
authors: MO
authors: Heller
authors: Norbert P
authors: NP
authors: Haas
authors: Carsten
authors: C
authors: Perka
authors: Klaus-D
authors: KD
authors: Schaser
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000502:physiology*; D003097:Collateral Circulation / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005269:Femur / Q000503:physiopathology; D050723:Fractures, Bone / Q000378:metabolism; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology*; D010521:Periosteum / Q000502:physiology; D016138:Walking / Q000502:physiology; D014945:Wound Healing / Q000502:physiology