Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia.
OBJECTIVE
We have previously reported a role for annexin-A1 in liver proliferation and tumorogenicity as well as its action as an acute phase protein in a model of endotoxemia in interleukin-6 null mice.


METHODS
In this study, we have investigated the analysis of the gene and protein expression in annexin-A1 null mice and the wild type livers during foetal and adult life, and in the presence of a proinflammatory stimulus.


RESULTS
The data indicate a link between the expression of the annexin-A1 as serine-phosphorylated-protein during early events of the inflammatory response and as tyrosine-phosphorylated-form at later time-points, during the resolution of inflammation.


CONCLUSIONS
The study of annexin-A1 post-translation modification may promote a new annexin-A1 peptide discovery programme to treat specific pathologies.
Damazo
A S
AS
Department of Biology, Instituto de Biociências, Letras e Ciências Exatas , São Paulo State University - UNESP, São José do Rio Preto, SP, 15054-000, Brazil. asdamazo@ibilce.unesp.br
Flower
R J
RJ
Solito
E
E
Oliani
S M
SM
D000818:Animals; D017305:Annexin A1 / Q000235:genetics* / Q000378:metabolism; D019446:Endotoxemia / Q000139:chemically induced*; D005786:Gene Expression Regulation; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational
D017305:Annexin A1; D015850:Interleukin-6; D008070:Lipopolysaccharides