Design and synthesis of new 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles as anticonvulsant agents.
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism.
Zarghi
Afshin
A
Department of Medicinal Chemistry, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. azarghi@yahoo.com
Hajimahdi
Zahra
Z
Mohebbi
Shohreh
S
Rashidi
Hootesa
H
Mozaffari
Sasan
S
Sarraf
Sahar
S
Faizi
Mehrdad
M
Tabatabaee
Seyed Abbas
SA
Shafiee
Abbas
A
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004597:Electroshock; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D010433:Pentylenetetrazole; D011963:Receptors, GABA-A / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D003292:Convulsants; D007202:Indicators and Reagents; D010069:Oxadiazoles; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole