Methotrexate rechallenge following delayed clearance and life-threatening toxicity.
Life-threatening toxicity is often a contraindication for cytotoxic treatment. Many childhood malignancies have good outcomes with appropriate aggressive chemotherapy. It is not easy to decide whether to subject a child with a good prognostic tumor to a drug that has previously caused significant toxicity. One such situation is documented in this report.
Anoop
Parameswaran
P
Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK.
Vaidya
Sucheta J
SJ
Mycroft
Julie
J
D001932:Brain Neoplasms / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*
D008727:Methotrexate