title: Increasing permeability of phospholipid bilayer membranes to alanine with synthetic alpha-aminophosphonate carriers.
abstract: A series of aminophosphonates was synthesized, and their ability to carry alanine, a model hydrophilic molecule, across phospholipid bilayer membranes was evaluated. Aminophosphonates facilitate the membrane transport at moderate rates, which make them a suitable platform for the design of carriers for continuous drug release devices.
authors: Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
authors: Delia C
authors: DC
authors: Danila
authors: Xinyan
authors: X
authors: Wang
authors: Heather
authors: H
authors: Hubble
authors: Igor S
authors: IS
authors: Antipin
authors: Eugene
authors: E
authors: Pinkhassik
mesh_terms: D000409:Alanine / Q000737:chemistry* / Q000378:metabolism; D001692:Biological Transport; D002463:Cell Membrane Permeability / Q000187:drug effects* / Q000502:physiology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000494:pharmacology*; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D063065:Organophosphonates / Q000138:chemical synthesis / Q000494:pharmacology*; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008051:Lipid Bilayers; D063065:Organophosphonates; D010743:Phospholipids; D000409:Alanine