[TGF-beta signaling during bone metastasis of breast cancer and in-vivo imaging].
Transforming growth factor (TGF)-beta is a potent growth inhibitor of various types of cells, whereas it stimulates deposition of extracellular matrix proteins and induction of epithelial-to-mesenchymal transition (EMT). TGF-beta thus plays two distinct and opposing roles in cancer progression. In the present study, we have developed a useful method that enables monitoring of tumor and its TGF-beta signaling within the same animal using in vivo bioluminescent imaging.
Imamura
Takeshi
T
The Cancer Institute of the JFCR, Department of Biochemistry.
Hanyu
Aki
A
D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008156:Luciferases; D008164:Luminescent Proteins; D051379:Mice; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology*
D008164:Luminescent Proteins; D016212:Transforming Growth Factor beta; D008156:Luciferases