title: Effect of fractional urea clearance on survival of hemodialysis patients in relation to gender.
abstract: Many studies have demonstrated the relationship between dialysis dose and survival. Global mortality is similar among men and women; however, the influence of dialysis dose in the survival could be more intensive between women. Therefore, we conduct an observational study to evaluate the gender-related impact of single pool Kt/V (spKt/V) on the survival of patients submitted to hemodialysis in a university hospital. We found that survival was lower in groups with spKt/V smaller than 1.2 than in those with Kt/V between 1.2 and 1.4. Among female patients, spKt/V smaller than 1.2 had a more adverse effect in survival than among men with a comparable Kt/V. Otherwise, among women, the dialysis dose had an impact in survival even with Kt/V greater than 1.4. Thus, fractional urea clearance more heavily influenced the survival of females than males in hemodialysis patients.
authors: Department of Internal Medicine, Discipline of Nephrology of the Botucatu Medical School, UNESP, São Paulo, Brazil.
authors: Juliana Cunha
authors: JC
authors: Ferreira
authors: Luís Gustavo Modelli
authors: LG
authors: de Andrade
authors: Pasqual
authors: P
authors: Barretti
authors: Jaqueline Costa Teixeira
authors: JC
authors: Caramori
authors: André Luís
authors: AL
authors: Balbi
authors: Luis Cuadrado
authors: LC
authors: Martin
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis; D012737:Sex Factors; D014508:Urea / Q000032:analysis*
chemical_list: D014508:Urea