Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors: allopurinol, febuxostat, and FYX-051.
Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR can thus decrease the concentration of uric acid in serum. Crystal structures of XOR bound with various inhibitors reveal that inhibitors can be categorized into three types, i.e. mechanism-based, structure-based, and hybrid types.
Okamoto
Ken
K
Department of Medical and Biological Chemistry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Nishino
Takeshi
T
D000493:Allopurinol / Q000737:chemistry*; D000818:Animals; D002384:Catalysis; D003460:Crystallization; D004791:Enzyme Inhibitors / Q000737:chemistry*; D000069465:Febuxostat; D008982:Molybdenum; D009570:Nitriles / Q000737:chemistry*; D011487:Protein Conformation; D011725:Pyridines / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*; D014968:Xanthine Dehydrogenase / Q000037:antagonists & inhibitors* / Q000737:chemistry*
D004791:Enzyme Inhibitors; D009570:Nitriles; D011725:Pyridines; D013844:Thiazoles; C504882:FYX-051; D000069465:Febuxostat; D000493:Allopurinol; D008982:Molybdenum; D014968:Xanthine Dehydrogenase