Alkaloids from Heimia salicifolia.
Two alkaloids, 9beta,2'-dihydroxy-4'',5''-dimethoxy-lythran-12-one or 9beta-hydroxyvertine (1) and (2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate (2), as well as seven known alkaloids, lythrine (3), dehydrodecodine (4), lythridine (5), vertine (6), heimidine (7), lyfoline (8) and epi-lyfoline (9), were isolated from Heimia salicifolia. The structures of these compounds were elucidated by extensive spectroscopic techniques. Furthermore, the structures of 2, 3, and 6 were confirmed by X-ray crystallography, including absolute configuration determination of 2 and 6. Compounds 6 and 9 showed moderate antimalarial activity.
Rumalla
Chidananda Swamy
CS
National Center for Natural Products Research, University of Mississippi, MS 38677, USA.
Jadhav
Atul N
AN
Smillie
Troy
T
Fronczek
Frank R
FR
Khan
Ikhlas A
IA
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D018360:Crystallography, X-Ray; D029561:Lythraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D011799:Quinazolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014709:Vero Cells
C531207:(2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate; C531208:9beta,2'-dihydroxy-4'',5''-dimethoxy-lythran-12-one; D000470:Alkaloids; D000890:Anti-Infective Agents; D000962:Antimalarials; D011799:Quinazolines; D011804:Quinolines