title: Terbinafine susceptibility patterns for onychomycosis-causative dermatophytes and Scopulariopsis brevicaulis.
abstract: The in vitro antifungal activity of terbinafine against 521 clinical isolates of seven species of dermatophytes, including four onychomycosis-causative species, as well as five Scopulariopsis brevicaulis isolates was determined by a modified Clinical and Laboratory Standards Institute microdilution method. Results showed a high antifungal activity of terbinafine against all dermatophyte isolates (geometric minimal inhibitory concentration (MIC)=0.026 microg/mL; concentration inhibiting 50% of mycological growth (MIC50)=0.03 microg/mL; and concentration inhibiting 90% of mycological growth (MIC90)=0.06 microg/mL). The geometric mean MICs against onychomycosis-causative dermatophyte species was lower (0.024 microg/mL) than the global MIC. However, the in vitro activity of terbinafine against S. brevicaulis was considerably lower (geometric mean MIC=1.38 microg/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.
authors: Departamento de Microbiología, ACIA, P.O. Box 10178, E-08080 Barcelona, Spain. alfonso@aciam.com
authors: Alfonso-Javier
authors: AJ
authors: Carrillo-Muñoz
authors: Gustavo
authors: G
authors: Giusiano
authors: Delia
authors: D
authors: Cárdenes
authors: Juan-Manuel
authors: JM
authors: Hernández-Molina
authors: Elena
authors: E
authors: Eraso
authors: Guillermo
authors: G
authors: Quindós
authors: Celia
authors: C
authors: Guardia
authors: Oscar
authors: O
authors: del Valle
authors: Cristina
authors: C
authors: Tur-Tur
authors: Josep
authors: J
authors: Guarro
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D003470:Culture Media; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D014009:Onychomycosis / Q000382:microbiology*; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine