Hemodynamic alterations during orthotopic liver experimental transplantation in pigs.
OBJECTIVE
To describe the hemodynamic alterations during orthotopic liver transplantation in pigs.


METHODS
In the period from April 2004 to December 2005, forty-four female Landrace pigs, weighting between 32 and 38 Kg underwent orthotopic liver transplantation. The animals were divided into two groups, donor and recipient pairs, which received whole liver grafts. The surgical procedure was divided into four parts: harvested, back-table, hepatectomy of the recipient and implantation. We analyzed heart rate, blood gas, mean systemic arterial pressure (MAP-mmHg), central venous pressure, pH, Na-, K+, Cl-, Ca+ and urinary output.


RESULTS
The mean anhepatic time was 69 min, cold ischemia was 252.2 min and back-table was 56.6 min. Blood pressure and heart rate dropped significantly during anhepatic phase and after revascularization. Blood gas and electrolytes alterations were observed during anhepatic and reperfusion phases. Although alterations were noted during these phases, the hemodynamic status was recovered and stabilized in the end of the surgery.


CONCLUSIONS
Simplified technique of liver transplant was achieved and description of hemodynamic alterations was possible in pigs.
Torres
Orlando Jorge Martins
OJ
Department of Surgery, Federal University of Maranhão, Brazil. o.torres@uol.com.br
Pantoja
Patrícia Brandão
PB
Barbosa
Erica Sampaio
ES
Barros
Cristiany de Almeida
Cde A
Servin
Elizabeth Teixeira Noguera
ET
Servin
Santiago Cirilo Noguera
SC
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D004573:Electrolytes / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D016031:Liver Transplantation / Q000502:physiology*; D013552:Swine
D004573:Electrolytes