Similar increase in oxidative stress after fat overload in persons with baseline hypertriglyceridemia with or without the metabolic syndrome.
OBJECTIVE
We compared the levels of biomarkers of oxidative stress before and after a fat overload in three groups.


METHODS
17 controls and two groups with hypertriglyceridemia: 43 without the metabolic syndrome (TG-non-MS) and 29 with the metabolic syndrome (TG-MS). All subjects underwent a 60 g fat overload. Baseline measurements included glucose, BMI (body mass index), waist circumference and HOMA IR (homeostasis model assessment insulin resistance). Cholesterol, triglycerides, HDL (high density lipoprotein) cholesterol, TNF-alpha (tumor necrosis factor) and IL-6 (interleukin-6), lipoperoxide (LPO), carbonylated proteins, reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GSH-PX), glutathione reductase (GSH-Rd), catalase and glutathione transferase (GST) were measured at baseline and 3 h after fat overload.


RESULTS
Compared to the controls, the two patient groups had higher plasma levels at baseline and after overload of cholesterol, triglycerides and apolipoprotein B, LPO, carbonylated proteins and GSSG, and lower levels of antioxidants at baseline and after the fat overload.


CONCLUSIONS
The two patient groups had the same degree of oxidative stress.
Cardona
F
F
Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de Victoria, 29009 Malaga and CIBER Fisiopatología Obesidad y Nutrición (CB06/03) Instituto de Salud Carlos III, Spain.
Tunez
I
I
Tasset
I
I
Murri
M
M
Tinahones
F J
FJ
D000328:Adult; D004041:Dietary Fats / Q000009:adverse effects* / Q000097:blood*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000150:complications / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*
D004041:Dietary Fats