Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080.
New phenolic mono- and digalactopyranosides (1 and 2), their aglycone KS-501a (3), and a new phenolic 4-O-methylglucopyranoside (4) were isolated from the filamentous fungus Acremonium sp. BCC 14080. Structures of these compounds were elucidated by extensive MS and NMR spectroscopic analyses. Compound 1 displayed anti-HSV-1 activity with an IC(50) value of 7.2 microM. Compound 3 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 9.9 microM.
Bunyapaiboonsri
Taridaporn
T
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong 1, Klong Luang, Pathumthani, Thailand. taridaporn@biotec.or.th
Yoiprommarat
Seangaroon
S
Khonsanit
Artit
A
Komwijit
Somjit
S
D000164:Acremonium / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000998:Antiviral Agents; D006027:Glycosides; D062385:Hydroxybenzoates; D010636:Phenols; C060468:KS 501