Microwave-assisted ring-opening of activated aziridines with resin-bound amines.
This paper describes the first study of nucleophilic ring-opening of nosylamide-activated aziridines under microwave irradiation conditions in solid-phase synthesis (SPS). The effects of solvent, temperature, reaction time, and reagent ratio in SPS of partially protected triamines from aziridines and resin-bound diamines were investigated. The methodology was also optimized for the synthesis of novel amino acid derivatives.
Crestey
François
F
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Witt
Matthias
M
Frydenvang
Karla
K
Staerk
Dan
D
Jaroszewski
Jerzy W
JW
Franzyk
Henrik
H
D000588:Amines / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D008872:Microwaves; D015394:Molecular Structure
D000588:Amines; D001388:Aziridines