Regulation of type II fatty acid synthase in Gram-positive bacteria.
Bacterial cells stringently regulate the synthesis of their membrane phospholipids but the responsible mechanisms are incompletely understood. Recent biochemical, genetic and structural analyses have greatly expanded the knowledge of lipid metabolism in Gram-positive bacteria, revealing that these organisms use novel mechanisms to regulate this essential pathway. A remarkable progress was the identification of a new pathway for the initiation of phospholipid biosynthesis that uncovered a mechanism that coordinates fatty acid and phospholipid biosynthesis. Recent advances in structure determination of a global transcription factor have led to significant insights of the underlying complexities and functional elegance of membrane lipid homeostasis in Gram-positive bacteria.
Schujman
Gustavo E
GE
Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET) and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. schujman@ibr.gov.ar
de Mendoza
Diego
D
D054889:Fatty Acid Synthase, Type II / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006094:Gram-Positive Bacteria / Q000201:enzymology* / Q000235:genetics; D008563:Membrane Lipids / Q000096:biosynthesis* / Q000737:chemistry; D008958:Models, Molecular; D010743:Phospholipids / Q000096:biosynthesis; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D008563:Membrane Lipids; D010743:Phospholipids; D014157:Transcription Factors; D054889:Fatty Acid Synthase, Type II