Mesh repair of common abdominal hernias: a review on experimental and clinical studies.
Results on hernia surgery from numerous centers confirm that tensionless repair with various meshes reduces the complication rates and the frequency of recurrences. Some evidence on incisional hernias suggests, however, that the use of mesh seems to transfer the onset of recurrences by several years. Persistent pain and other discomfort is also an unpleasant complication of otherwise successful surgery in a number of patients. Thus, improved, slowly degrading, mesh materials, with strong connective tissue-inducing action, might be more optimal for hernia surgery. Accumulating evidence also suggests that recurrent hernias appear in patients having inherited weakness of connective tissues. Numerous tissue specific collagens, in addition to the classical fibrillar I-III collagens and numerous substrate specific matrix proteinases, have recently been described in biochemical literature, and their roles as possible causes of tissue weakness are discussed.
Penttinen
R
R
Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, Turku, Finland. rispen@utu.fi
Grönroos
J M
JM
D000818:Animals; D004195:Disease Models, Animal; D046449:Hernia, Abdominal / Q000601:surgery*; D006801:Humans; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000295:instrumentation*; D013526:Surgical Mesh; D016896:Treatment Outcome