Concise synthesis of (S)-N-BOC-2-hydroxymethylmorpholine and (S)-N-BOC-morpholine-2-carboxylic acid.
An operationally simple synthesis of N-BOC-2-hydroxymethylmorpholine (1) and N-BOC-morpholine-2-carboxylic acid (2) from epichlorohydrin has been developed. No chromatography is required in the processing, which allows high process throughput.
Henegar
Kevin E
KE
Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton Connecticut 06340, USA. kevin.e.henegar@pfizer.com
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry
D002264:Carboxylic Acids; D009025:Morpholines; C529508:N-tert-butoxycarbonyl-2-hydroxymethylmorpholine; C529509:N-tert-butoxycarbonyl-2-morpholine-2-carboxylic acid