Studies of focal adhesion assembly.
Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction sites whose affinity can be adjusted by conformational masking and phosphorylation.
Campbell
Iain D
ID
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. idc@bioch.ox.ac.uk
D002448:Cell Adhesion / Q000502:physiology; D003285:Contractile Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D005353:Fibronectins / Q000502:physiology*; D064448:Filamins; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008840:Microfilament Proteins / Q000502:physiology*; D008954:Models, Biological; D010750:Phosphoproteins / Q000502:physiology*; D011485:Protein Binding; D011487:Protein Conformation; D016601:RNA-Binding Proteins / Q000502:physiology*; D016608:Talin / Q000502:physiology*
D003285:Contractile Proteins; D004268:DNA-Binding Proteins; C489560:DOK1 protein, human; D005353:Fibronectins; D064448:Filamins; D016023:Integrins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D016608:Talin