Decreasing age disparities in syphilis and gonorrhea incidence rates in the United States, 1981--2005.
BACKGROUND
Compared to older age groups, teenagers and young adults in the United States are at high risk of acquiring sexually transmitted diseases (STDs). Although the disparity in STD rates across age groups is well documented, changes in the degree of disparity in STD rates across age groups over time have not been examined in detail.


METHODS
We examined age-, sex-, and race-specific incidence rates of syphilis and gonorrhea in the United States (excluding New York owing to incomplete age- and race-specific data) from 1981 to 2005. STD rates in younger age groups (ages 15-29 years) were compared to STD rates in older age groups (ages 40-54 years) for each year over the 25-year period. We used regression analyses to examine the trend in the age rate ratio (STD rate in the younger age group divided by STD rate in the older age group) over time, adjusting for autocorrelation.


RESULTS
The age disparity in syphilis and gonorrhea declined from 1981 to 2005. The estimated annual decline in the age rate ratio was 5.3% for syphilis and 2.0% for gonorrhea for all races overall (P <0.01). Overall, the age disparity in STD rates was more pronounced for females than males.


CONCLUSIONS
Future research is needed to clarify the main determinants of the relative decline in STD rates in younger persons and to inform programmatic responses to the changing age disparity in STD rates.
Chesson
Harrell W
HW
Division of STD Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. hchesson@cdc.gov
Zaidi
Akbar A
AA
Aral
Sevgi O
SO
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D002487:Centers for Disease Control and Prevention, U.S.; D005260:Female; D006069:Gonorrhea / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D017678:Sex Distribution; D013587:Syphilis / Q000453:epidemiology* / Q000208:ethnology; D014481:United States / Q000453:epidemiology / Q000208:ethnology