Stem cells remember their grade.
The stem cell state is understood based on what cells do in performance assays, crude measures of a highly refined state. In this issue of Cell Stem Cell, Dykstra et al. (2007) reveal stem cell gradation and the extent to which that gradation is retained in stem cell daughters of hematopoietic stem cells.
Lo Celso
Cristina
C
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute, Boston, MA 02114, USA.
Scadden
David T
DT
D053687:Adult Stem Cells / Q000637:transplantation; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice