title: Effects of functional overloading on the regenerative potential of injured skeletal muscles in mice.
abstract: The purpose of this study was to investigate the effects of functional overload on the regeneration of injured skeletal muscles of male C57BL/6J mice. To activate a necrosis-regeneration cycle, cardiotoxin (CTX) was injected into soleus muscles both control and functionally overloaded groups. The recovery of muscle protein content, which was decreased by CTX injection, was significantly stimulated by application of functional overloading. The CTX-injection-related increment of satellite cell number in the overloaded groups was also greater than that in the group without overloading. Evidences suggest that the application of a mechanical stress on the injured skeletal muscles could activate satellite cells and facilitate the regeneration of the muscle.
authors: Laboratory of Physiology, Toyohashi SOZO University, Toyohashi 440-8511, Japan. gotok@sepia.ocn.ne.jp
authors: Katsumasa
authors: K
authors: Goto
authors: Shigeta
authors: S
authors: Morioka
authors: Toshihito
authors: T
authors: Naito
authors: Tatsuo
authors: T
authors: Akema
authors: Yusuke
authors: Y
authors: Matsuba
authors: Takao
authors: T
authors: Sugiura
authors: Yoshinobu
authors: Y
authors: Ohira
authors: Toshitada
authors: T
authors: Yoshioka
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004179:Cobra Cardiotoxin Proteins; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D009135:Muscular Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D009336:Necrosis; D009929:Organ Size; D051763:PAX7 Transcription Factor / Q000378:metabolism; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000473:pathology; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D004179:Cobra Cardiotoxin Proteins; D009124:Muscle Proteins; D051763:PAX7 Transcription Factor