title: Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites.
abstract: Novel bioactive glass (BG) nanoparticles/poly(L-lactide) (PLLA) composites were prepared as promising bone-repairing materials. The BG nanoparticles (Si:P:Ca=29:13:58 weight ratio) of about 40nm diameter were prepared via the sol-gel method. In order to improve the phase compatibility between the polymer and the inorganic phase, PLLA (M(n)=9700Da) was linked to the surface of the BG particles by diisocyanate. The grafting ratio of PLLA was in the vicinity of 20 wt.%. The grafting modification could improve the tensile strength, tensile modulus and impact energy of the composites by increasing the phase compatibility. When the filler loading reached around 4 wt.%, the tensile strength of the composite increased from 56.7 to 69.2MPa for the pure PLLA, and the impact strength energy increased from 15.8 to 18.0 kJ m(-2). The morphology of the tensile fracture surface of the composite showed surface-grafted bioactive glass particles (g-BG) to be dispersed homogeneously in the PLLA matrix. An in vitro bioactivity test showed that, compared to pure PLLA scaffold, the BG/PLLA nanocomposite demonstrated a greater capability to induce the formation of an apatite layer on the scaffold surface. The results of marrow stromal cell culture revealed that the composites containing either BG or g-BG particles have much better biocompatibility compared to pure PLLA material.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
authors: Aixue
authors: A
authors: Liu
authors: Zhongkui
authors: Z
authors: Hong
authors: Xiuli
authors: X
authors: Zhuang
authors: Xuesi
authors: X
authors: Chen
authors: Yang
authors: Y
authors: Cui
authors: Yi
authors: Y
authors: Liu
authors: Xiabin
authors: X
authors: Jing
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D003461:Crystallography; D005898:Glass / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism*; D011817:Rabbits; D012825:Silicon; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D012825:Silicon