New ways to identify novel bacterial antigens for vaccine development.
This article provides an overview of developments in approaches to identify novel bacterial components for use in recombinant subunit vaccines. In particular it describes the processes involved in "reverse vaccinology", and some associated complementary technologies such as proteomics that can be used in the identification of new and potentially useful vaccine antigens. Results obtained from the application of these new methods are forming a basis for a new generation of vaccines for use in the control of bacterial infections of humans and animals.
Movahedi
Abdolreza Reza
AR
School of Veterinary and Biomedical Science, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia.
Hampson
David J
DJ
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics*; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity; D001424:Bacterial Infections / Q000517:prevention & control* / Q000662:veterinary; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001428:Bacterial Vaccines / Q000235:genetics* / Q000276:immunology*; D035843:Biomedical Research; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D040901:Proteomics; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic