title: Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus.
abstract: In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), and ellagic acid (4). Their structures were elucidated by spectroscopic analyses. Among them, davallialactone (7), hypholomine B (9), and ellagic acid (4) exhibited potent rat lens aldose reductase and human recombinant aldose reductase inhibitory activity with IC50 values of 0.33, 0.82, 0.63 microM and 0.56, 1.28, 1.37 microM, respectively.
authors: Department of Food Science and Nutrition, Hallym University, Chuncheon 200-702, Korea.
authors: Yeon Sil
authors: YS
authors: Lee
authors: Young-Hee
authors: YH
authors: Kang
authors: Ju-Young
authors: JY
authors: Jung
authors: Il-Jun
authors: IJ
authors: Kang
authors: Sang-No
authors: SN
authors: Han
authors: Jong-Sang
authors: JS
authors: Chung
authors: Hyun-Kyung
authors: HK
authors: Shin
authors: Soon Sung
authors: SS
authors: Lim
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D005612:Freeze Drying; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D007202:Indicators and Reagents; D007908:Lens, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D011994:Recombinant Proteins; D000449:Aldehyde Reductase