title: The associations of regional adipose tissue with lipid and lipoprotein levels in HIV-infected men.
abstract: BACKGROUND
  HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional adipose tissue depots and lipid levels is not defined.
  
  
  METHODS
  The association of magnetic resonance imaging-measured visceral adipose tissue (VAT) and regional subcutaneous adipose tissue (SAT) volume with fasting lipid parameters was analyzed by multivariable linear regression in 737 HIV-infected and 145 control men from the study of Fat Redistribution and Metabolic Change in HIV Infection.
  
  
  RESULTS
  HIV-infected men had higher median triglycerides (170 mg/dL vs. 107 mg/dL; P < 0.0001), lower high-density lipoprotein cholesterol (HDL-C; 38 mg/dL vs. 46 mg/dL; P < 0.0001), and lower low-density lipoprotein cholesterol (LDL-C; 105 mg/dL vs. 125 mg/dL; P < 0.0001) than controls. After adjustment, greater VAT was associated with higher triglycerides and lower HDL-C in HIV-infected and control men, whereas greater leg SAT was associated with lower triglycerides in HIV-infected men with a similar trend in controls. More upper trunk SAT was associated with higher LDL-C and lower HDL-C in controls, whereas more lower trunk SAT was associated with higher triglycerides in controls. After adjustment, HIV infection remained strongly associated (P < 0.0001) with higher triglycerides (+76%, 95% confidence interval [CI]: 53 to 103), lower LDL-C (-19%, 95% CI: -25 to -12), and lower HDL-C (-18%, 95% CI: -22 to -12).
  
  
  CONCLUSIONS
  HIV-infected men are more likely than controls to have higher triglycerides and lower HDL-C, which promote atherosclerosis, but also lower LDL-C. Less leg SAT and more VAT are important factors associated with high triglycerides and low HDL-C in HIV-infected men. The reduced leg SAT in HIV-infected men with lipoatrophy places them at increased risk for proatherogenic dyslipidemia.
authors: AIDS Clinical Trials Unit, University of North Carolina, Chapel Hill, NC, USA.
authors: David
authors: D
authors: Wohl
authors: Rebecca
authors: R
authors: Scherzer
authors: Steven
authors: S
authors: Heymsfield
authors: Michael
authors: M
authors: Simberkoff
authors: Stephen
authors: S
authors: Sidney
authors: Peter
authors: P
authors: Bacchetti
authors: Carl
authors: C
authors: Grunfeld
mesh_terms: D000328:Adult; D015658:HIV Infections / Q000378:metabolism*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D015999:Multivariate Analysis; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D014280:Triglycerides