title: Up-regulation of stromal cell-derived factor-1alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma.
abstract: Stromal cell-derived factor 1alpha (SDF-1alpha) and its receptor CXCR4 have been implicated in the tumorigenesis, proliferation, and lymph node metastasis of cancer. Here, we report that highly invasive squamous cell carcinoma (SCC) cells with a spindle cell morphology show a strong expression of both SDF-1alpha and CXCR4. CXCR4 expression and cell migratory activity were further up-regulated by treatment with SDF-1alpha or TGF-beta1 in these cells. When epithelial-mesenchymal transition (EMT) was induced by Snail over-expression in SCC cells with an epithelial phenotype, an increased expression of SDF-1alpha was observed. Furthermore, SDF-1alpha and TGF-beta1 up-regulated the expression of CXCR4 and cell migratory activity in these cells. These results indicate that SDF-1alpha and CXCR4 expressions are possible markers of highly-invasive SCC and regulated by EMT.
authors: Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
authors: Masayuki
authors: M
authors: Taki
authors: Koichiro
authors: K
authors: Higashikawa
authors: Shingo
authors: S
authors: Yoneda
authors: Shigehiro
authors: S
authors: Ono
authors: Hideo
authors: H
authors: Shigeishi
authors: Masaru
authors: M
authors: Nagayama
authors: Nobuyuki
authors: N
authors: Kamata
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000502:physiology*; D004848:Epithelium / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology*; D019718:Receptors, CXCR4 / Q000502:physiology*; D015854:Up-Regulation
chemical_list: C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4