title: Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans.
abstract: We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.
authors: Department of Nuclear Medicine, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany.
authors: Ruth A
authors: RA
authors: Bryan
authors: Xianchun
authors: X
authors: Huang
authors: Alfred
authors: A
authors: Morgenstern
authors: Frank
authors: F
authors: Bruchertseifer
authors: Arturo
authors: A
authors: Casadevall
authors: Ekaterina
authors: E
authors: Dadachova
mesh_terms: D000512:Alpha Particles; D000818:Animals; D000911:Antibodies, Monoclonal; D017209:Apoptosis / Q000528:radiation effects; D001610:Beta Particles; D001729:Bismuth; D002463:Cell Membrane Permeability / Q000528:radiation effects*; D015169:Colony Count, Microbial; D003455:Cryptococcus neoformans / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D011868:Radioisotopes; D012211:Rhenium; D013778:Tetrazolium Salts / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D013778:Tetrazolium Salts; C059087:2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide; D012211:Rhenium; D001729:Bismuth