mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells.
mAtNOS1 is a novel gene recently reported in mammalian cells with functions that are not fully understood. The present study generated human neuroblastoma SHSY cells over- and underexpressing mAtNOS1 and shows that mAtNOS1 is involved in regulating mitochondrial nitric oxide, mitochondrial transmembrane potential, protein tyrosine nitration, cytochrome c release, and apoptosis of those cells.
Parihar
Mordhwaj S
MS
Department of Surgery, Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Parihar
Arti
A
Chen
Zhonghai
Z
Nazarewicz
Rafal
R
Ghafourifar
Pedram
P
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000196:embryology / Q000378:metabolism; D019556:COS Cells; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008564:Membrane Potentials / Q000235:genetics; D051379:Mice; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009447:Neuroblastoma / Q000235:genetics / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013950:Thymus Gland / Q000196:embryology / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D029681:Arabidopsis Proteins; D009363:Neoplasm Proteins; D009569:Nitric Oxide; C521947:NOA1 protein, Arabidopsis; D019001:Nitric Oxide Synthase; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; C539734:NOA1 protein, human