title: Survival and health in liveborn infants with transposition of great arteries--a population-based study.
abstract: OBJECTIVE
  To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).
  
  
  METHODS
  Population-based data from 7 European registries of congenital malformations (EUROCAT).
  
  
  RESULTS
  Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.
  
  
  CONCLUSIONS
  In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.
authors: Paediatric Department, Kolding Hospital, Kolding, Denmark. egarne@health.sdu.dk
authors: Ester
authors: E
authors: Garne
authors: Maria A
authors: MA
authors: Loane
authors: Vera
authors: V
authors: Nelen
authors: Marian K
authors: MK
authors: Bakker
authors: Blanca
authors: B
authors: Gener
authors: Lenore
authors: L
authors: Abramsky
authors: Marie-Claude
authors: MC
authors: Addor
authors: Annette
authors: A
authors: Queisser-Luft
mesh_terms: D006348:Cardiac Surgical Procedures; D005500:Follow-Up Studies; D006801:Humans; D007229:Infant Welfare; D007231:Infant, Newborn; D050498:Live Birth; D011296:Prenatal Diagnosis; D015995:Prevalence; D011453:Prostaglandins / Q000627:therapeutic use; D012042:Registries; D016019:Survival Analysis; D014188:Transposition of Great Vessels / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology* / Q000628:therapy
chemical_list: D011453:Prostaglandins