Tracing the life of the kidney tubule- re-establishing dogma and redirecting the options.
Renal pathology suggests that tubular repair results from tubular proliferation. In contrast, recent studies propose that postnatal kidney repair may involve renal stem cells. In this issue of Cell Stem Cell, Humphreys et al. (2008) use lineage tracing to genetically assess contribution of adult nontubular cells (potentially stem cells) to repair of damaged renal tubules.
Little
Melissa H
MH
Australian Stem Cell Centre, The University of Queensland, Brisbane 4072, Australia. melissa.little@stemcellcentre.edu.au
D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D012038:Regeneration; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors