Graft loss associated with late humoral rejection after renal transplantation.
Antibody-mediated rejection (AMR) is an important cause of renal allograft loss after renal transplantation. With the improvement of the crossmatching method and the use of more aggressive immunosuppressants, the incidence and outcome of early AMR has been reduced. Late humoral rejection is becoming an important cause of graft loss. In this chapter, we demonstrated 8 renal allograft recipients who experienced renal allograft dysfunction associated with late humoral rejection, which suggests that graft loss could be caused by anti-donor antibodies.
Sun
Qiquan
Q
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Li
Leishi
L
D000328:Adult; D000917:Antibody Formation; D015935:Complement C4b / Q000032:analysis; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000145:classification / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d