Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).
The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).
Matsumoto
Norimasa
N
Research Laboratory, Taito Co Ltd, Kobe, Japan.
Hirose
Ryoji
R
Sasaki
Shigeo
S
Fujita
Tetsuro
T
D000068876:Fingolimod Hydrochloride; D007155:Immunologic Factors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011409:Propylene Glycols / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D007155:Immunologic Factors; D007202:Indicators and Reagents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine