Disease pattern recognition in infrared spectra of human sera with diabetes mellitus as an example.
To benefit from the full information content of the mid-IR spectra of human sera, we directly related the overall shape of the spectra to the donors' disease states. For this approach of disease pattern recognition we applied cluster analysis and discriminant analysis to the example of the disease states diabetes type 1, diabetes type 2, and healthy. In a binary, supervised classification of any pair of these disease states we achieved specificities and sensitivities of approximately 80% within our data set.
Petrich
W
W
Roche Diagnostics GmbH, Sandhofer Strasse 116, 68305 Mannheim, Germany. wolfgang.petrich@roche.com
Dolenko
B
B
Früh
J
J
Ganz
M
M
Greger
H
H
Jacob
S
S
Keller
F
F
Nikulin
A E
AE
Otto
M
M
Quarder
O
O
Somorjai
R L
RL
Staib
A
A
Werner
G
G
Wielinger
H
H