title: Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort.
abstract: BACKGROUND
  Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR.
  
  
  METHODS
  Type 2 diabetic patients with and without retinopathy were recruited. The -634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests.
  
  
  RESULTS
  No significant association was observed between genotypes, alleles and haplotypes of -634C/G and 936C/T polymorphisms and DR or its severity. However, C(-634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3).
  
  
  CONCLUSIONS
  Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.
authors: SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
authors: Satagopan
authors: S
authors: Uthra
authors: Rajiv
authors: R
authors: Raman
authors: Bickol N
authors: BN
authors: Mukesh
authors: Samuel A
authors: SA
authors: Rajkumar
authors: Kumari R
authors: KR
authors: Padmaja
authors: Pradeep G
authors: PG
authors: Paul
authors: Praveena
authors: P
authors: Lakshmipathy
authors: Perumal
authors: P
authors: Gnanamoorthy
authors: Tarun
authors: T
authors: Sharma
authors: Catherine A
authors: CA
authors: McCarty
authors: Govindasamy
authors: G
authors: Kumaramanickavel
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000209:etiology; D044466:Asian People / Q000235:genetics*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000652:urine; D003930:Diabetic Retinopathy / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A