DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
Genetic association of the dynamin binding protein gene (DNMBP) on chromosome 10 with late-onset Alzheimer's disease (AD) was reported among Japanese. Here, we assessed the genetic role of DNMBP in an extended Belgian AD group using a gene-wide association approach. A total of 18 SNPs across the DNMBP locus were genotyped in 555 late-onset AD patients and 638 healthy control individuals. Significant associations were observed for two SNPs (rs3740057 and rs10883421). Haplotype analysis identified association with haplotype blocks in the 3' region of DNMBP comprising rs2862919, rs11190302, rs10509739, rs2256700 and comprising rs3740057 and rs6584331. Stratification for APOE epsilon4 status showed that association was only present in the APOE epsilon4 negative subgroup. Sliding-window analyses provided further evidence for association with the 3'-end of DNMBP both for the total and for the APOE epsilon4 negative group. Taken together our findings underscore a role for DNMBP in the genetic risk for late-onset AD in the Belgian population.
Bettens
Karolien
K
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium.
Brouwers
Nathalie
N
Engelborghs
Sebastiaan
S
De Pooter
Tim
T
De Deyn
Peter P
PP
Sleegers
Kristel
K
Van Broeckhoven
Christine
C
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D001530:Belgium / Q000453:epidemiology; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D053327:Apolipoprotein E4; D003598:Cytoskeletal Proteins; C482331:DNMBP protein, human