The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery.
BACKGROUND
Previous studies addressing the changes in serum visfatin levels after bariatric surgery yielded conflicting results.


METHODS
We measured serum visfatin levels in 41 morbidly obese women before bariatric surgery and after losing at least 15% of the initial weight, and analyzed the results taking into account the type of surgery, reproductive and diabetic status, among others. Body mass index, waist circumference, lipid profile, and insulin resistance determined by homeostasis model assessment (HOMA-IR) were also measured.


RESULTS
Patients lost 30.3 +/- 6.1% of the initial body weight, and serum visfatin levels increased from 22.2 +/- 20.9 to 32.2 +/- 27.6 ng/ml (P = 0.031). A multiple regression model (R (2) = 0.314, F = 3.555, P = 0.017) including the percentage of weight loss, changes in waist circumference, HOMA-IR, high-density lipoprotein-cholesterol, and triglycerides (also expressed as percentage from baseline), the surgical procedure, time elapsed since surgery, and previous diabetic status as independent variables showed that weight loss (beta = -0.670, P = 0.010), previous diabetic status (beta = -0.330, P = 0.036), and change in waist circumference (beta = 0.556, P = 0.031) were the main determinants of the percentual increase in serum visfatin levels observed after bariatric surgery.


CONCLUSIONS
Serum visfatin increased after bariatric surgery in relation to the amount of weight lost and to the changes in waist circumference, and this increase was higher in diabetic patients.
Botella-Carretero
José I
JI
Department of Endocrinology, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, Carretera de Colmenar Km. 9.1, Madrid, Spain.
Luque-Ramírez
Manuel
M
Alvarez-Blasco
Francisco
F
Peromingo
Roberto
R
San Millán
José L
JL
Escobar-Morreale
Héctor F
HF
D000328:Adult; D050110:Bariatric Surgery; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications / Q000601:surgery*; D017698:Postmenopause; D017697:Premenopause; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human