title: Effect of lumen narrowing within sirolimus-eluting stents on proximal and distal vessel segments.
abstract: BACKGROUND
  Flow dynamics and shear stress may influence downstream vessel segments. The aim of this study was to investigate the potential impact of lumen narrowing within sirolimus-eluting stents (SES) on vessel response at adjacent reference sites.
  
  
  RESULTS
  In 135 patients after SES implantation, minimal lumen area (MLA) within the stent and average lumen area at distal or proximal adjacent reference segments (5 mm) were obtained at baseline and follow up. In the smaller in-stent MLA group (MLA <3 mm(2)), lumen area decreased significantly at the distal reference compared with the larger in-stent MLA group (MLA >or=3 mm(2)), although no significant difference was seen at the proximal reference.
  
  
  CONCLUSIONS
  In-stent lumen patency may influence vascular responses at adjacent reference segments after SES implantation.
authors: Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, CA, USA
authors: Katsuhisa
authors: K
authors: Waseda
authors: Junya
authors: J
authors: Ako
authors: Hideaki
authors: H
authors: Kaneda
authors: Akiyoshi
authors: A
authors: Miyazawa
authors: Yoshihisa
authors: Y
authors: Shimada
authors: Yoshihiro
authors: Y
authors: Morino
authors: Yasuhiro
authors: Y
authors: Honda
authors: Peter J
authors: PJ
authors: Fitzgerald
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012449:Safety; D020123:Sirolimus / Q000008:administration & dosage*; D014463:Ultrasonography
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus