Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases.
In recent years, novel therapeutic strategies have become available for the treatment of chronic inflammatory disease. Neutralizing proinflammatory mediators such as leukotrienes and TNF-alpha, in addition to anti-IgE therapies (Omaluzimab) that target higher in the inflammatory cascade, have shown success in the treatment of allergic or autoimmune disorders. Free immunoglobulin light chains, which are produced by B lymphocytes and secreted into serum, might play a crucial role in the pathogenesis of inflammatory disease. Concentrations of free light chains are significantly increased under diverse pathological conditions in humans, and have been linked to the progression and severity of immune diseases. Here we discuss the importance of free immunoglobulin light chains as a potential therapeutic target in the treatment of chronic inflammatory disease.
Thio
Marco
M
Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Blokhuis
Bart R
BR
Nijkamp
Frans P
FP
Redegeld
Frank A
FA
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000209:etiology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000502:physiology*; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000209:etiology; D008407:Mast Cells / Q000502:physiology; D012220:Rhinitis / Q000188:drug therapy / Q000209:etiology
D007147:Immunoglobulin Light Chains