Association study of the HLA-A2 allele in Italian Alzheimer disease patients.
Association of the A2 allele of the human leukocyte antigen (HLA) with Alzheimer disease (AD) is still controversial. The authors evaluated HLA-A2 association with AD in 173 Italian AD patients, considering also the possible interaction with APOE pattern, age of onset and gender. No evidence of any association was found.
Guerini
Franca Rosa
FR
Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan, Italy. fguerini@dongnocchi.it
Calabrese
Elena
E
Agliardi
Cristina
C
Zanzottera
Milena
M
Franceschi
Massimo
M
Grimaldi
Luigi Maria Edoardo
LM
Nemni
Raffaello
R
Ferrante
Pasquale
P
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D015789:HLA-A2 Antigen / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D017422:Sequence Analysis, DNA; D012737:Sex Factors
D053327:Apolipoprotein E4; D015789:HLA-A2 Antigen