GATA-3 and the regulation of the mammary luminal cell fate.
The GATA family of transcription factors plays essential roles in the specification and maintenance of differentiated cell types. GATA-3 was identified in a microarray screen of the mouse mammary gland as the most highly expressed transcription factor in the mammary epithelium and is expressed exclusively in the luminal epithelial cell population. Targeted deletion of GATA-3 in mammary glands leads to profound defects in mammary development and inability to specify and maintain the luminal cell fate in the adult mouse. In breast cancer, GATA-3 has emerged as a strong predictor of tumor differentiation, estrogen-receptor status, and clinical outcome. GATA-3 maintains tumor differentiation and suppresses tumor dissemination in a mouse model of breast cancer. This review explores our current understanding of GATA-3 signaling in luminal cell differentiation, both in mammary development and breast cancer.
Kouros-Mehr
Hosein
H
Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, United States.
Kim
Jung-whan
JW
Bechis
Seth K
SK
Werb
Zena
Z
D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D019070:Cell Lineage; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D042361:Mammary Glands, Human / Q000166:cytology*
D050990:GATA3 Transcription Factor