Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization.
Precursor systems of liquid crystalline phase were prepared using the surfactant PPG-5-Ceteth-20, isopropyl myristate, and water; gelatin microparticles containing propolis were then added into these systems. Homogeneity of dispersion, the in-system microparticle morphology, and sedimentation behavior of each formulation were evaluated. The rheological and mechanical properties (hardness, compressibility, and adhesiveness), the work of syringing, and the propolis release profile were also evaluated. All the formulations exhibited pseudoplastic flow and thixotropy, and they displayed storage modulus, loss modulus, dynamic viscosity, and loss tangent that depended on temperature, frequency, and composition. Mechanical properties varied significantly among the formulations being affected by changes in the composition and temperature. Raising the concentration of surfactant and adding propolis microparticles significantly decreased the work of syringing. The drug release was non-Fickian (anomalous) and there was no significant difference between the tested systems in the times required for 10%, 30%, and 50% release of the initial drug loading.
Bruschi
Marcos Luciano
ML
Postgraduation Programme in Pharmaceutical Sciences, Pharmaceutical School of Ribeirao Preto, University of São Paulo, Brazil. bruschiml@yahoo.com.br
de Freitas
Osvaldo
O
Lara
Elza Helena Guimarã Es
EH
Panzeri
Heitor
H
Gremião
Maria Palmira Daflon
MP
Jones
David Simon
DS
D000268:Adhesiveness; D000890:Anti-Infective Agents / Q000737:chemistry*; D016503:Drug Delivery Systems; D005233:Fatty Alcohols / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D006244:Hardness; D050866:Liquid Crystals / Q000737:chemistry; D009226:Myristates / Q000737:chemistry; D010510:Periodontal Diseases / Q000188:drug therapy; D011429:Propolis / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D012212:Rheology; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature; D014783:Viscosity
D000890:Anti-Infective Agents; D005233:Fatty Alcohols; D009226:Myristates; D011409:Propylene Glycols; D013501:Surface-Active Agents; C008205:isopropyl myristate; D005780:Gelatin; D011429:Propolis; C005031:cetyl alcohol