Patent ductus arteriosus in preterm neonates.
Failure of the ductus arteriosus to close within 48-96 hours of postnatal age results in a left to right shunt across the ductus and overloading of the pulmonary circulation. This is more likely to happen in premature neonates with respiratory distress syndrome. Deterioration in the respiratory status on day 3-4 in a ventilated neonate and unexplained metabolic acidosis may be the earliest indicators of a patent ductus arteriosus (PDA). Indomethacin is the main stay of medical management of PDA in preterm neonates. Guidelines for administration of indomethacin have been described in the protocol. Restricted fluid therapy may be beneficial in the prevention of PDA in preterm neonates. Presence of PDA in a term neonate should be investigated to rule out an underlying congenital heart disease.
Agarwal
Ramesh
R
Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Deorari
Ashok K
AK
Paul
Vinod K
VK
D002317:Cardiovascular Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis* / Q000628:therapy*; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D012307:Risk Factors
D002317:Cardiovascular Agents; D007213:Indomethacin