Nanocapsule@xerogel microparticles containing sodium diclofenac: a new strategy to control the release of drugs.
The aim of this work was to evaluate the potentiality to control the drug release of a new architecture of microparticles organized at the nanoscopic scale by assembling polymeric nanocapsules at the surface of drug-loaded xerogels. Xerogel was prepared by sol-gel method using sodium diclofenac, as hydrophilic drug model, and coated by spray-drying. After coating, the surface areas decreased from 82 to 28 m(2)/g, the encapsulation efficiency was 71% and SEM analysis showed irregular microparticles coated by the nanocapsules. Formulation showed satisfactory gastro-resistance presenting drug release lower than 3% (60 min) in acid medium. In water, the pure drug dissolved 92% after 5 min, uncoated drug-loaded xerogel released 60% and nanocapsule coated drug-loaded xerogel 36%. After 60 min, uncoated drug-loaded xerogel released 82% and nanocapsule coated drug-loaded xerogel 62%. In conclusion, the new system was able to control the release of the hydrophilic drug model.
da Fonseca
Letícia Sias
LS
Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio Grande do Sul, CP 15003, Porto Alegre, RS, Brazil.
Silveira
Rodrigo Paulo
RP
Deboni
Alberto Marçal
AM
Benvenutti
Edilson Valmir
EV
Costa
Tânia M H
TM
Guterres
Sílvia S
SS
Pohlmann
Adriana R
AR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002867:Chromones; D003692:Delayed-Action Preparations; D003890:Desiccation; D004008:Diclofenac / Q000008:administration & dosage*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D009584:Nitrogen; D011109:Polymethacrylic Acids; D013499:Surface Properties
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; D004008:Diclofenac; C038300:methylmethacrylate-methacrylic acid copolymer; C469689:tricetin; D009584:Nitrogen