Selfish stem cells compete with each other.
Stem cell interactions with their niche have been well documented; however, the influences of stem cells on one another are rarely addressed. In this issue of Cell Stem Cell, Jin et al. (2008) demonstrate that stem cells compete for niche occupancy, ultimately leading to the domination of one stem cell population over time.
Yamashita
Yukiko M
YM
Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA. yukikomy@umich.edu
D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000502:physiology; D002450:Cell Communication; D016923:Cell Death; D002454:Cell Differentiation; D002470:Cell Survival; D004265:DNA Helicases / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology; D055153:Stem Cell Niche / Q000166:cytology / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D029721:Drosophila Proteins; D052004:Bone Morphogenetic Protein Receptors; D004265:DNA Helicases; C414082:bgcn protein, Drosophila