title: Evaluating the cell-mediated immune response of avian species to avian influenza viruses.
abstract: The measurement of avian cellular immunity is critical to understanding the role and regulation of avian lymphocytes following avian influenza (AI) virus infection. Although the ability to measure avian T cell responses has steadily increased over the last few years, few studies have examined the role of cell-mediated immunity in avian species against the AI virus. Because of the structural and functional differences between mammalian and avian immune systems-including MHC architecture, different modes of somatic recombination for antibody production, and the absence of lymph nodes in birds-the extent to which birds and mammals regulate similar immune responses against the AI virus is currently under investigation. The increasing availability of monoclonal antibodies recognizing avian T cell-associated antigens as well as a number of inbred lines of chickens with genetically defined MHC haplotypes make this an important field of research for the future.
authors: Southeast Poultry Research Laboratory, US Department of Agriculture, Agricultural Research Service, Athens, GA, USA.
authors: Darrell R
authors: DR
authors: Kapczynski
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D049109:Cell Proliferation; D002478:Cells, Cultured; D002645:Chickens; D005434:Flow Cytometry; D009980:Influenza A virus / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D000956:Antigens, Viral