Secondary myelofibrosis in children.
Myelofibrosis is a rare childhood myeloproliferative disorder. It has been reported as an associated complication of certain hematologic malignancies or as an isolated idiopathic process. We describe clinical course of 6 children diagnosed over 6 years. One child each responded well to steroid and treatment of the underlying condition. Three children died because of underlying conditions and 1 child was lost to follow up. A thorough search should be made for underlying disease when myelofibrosis is first diagnosed. Trephine biopsy though giving useful information, does not have a prognostic significance.
Naithani
Rahul
R
Department of Hematology, All India Institute of Medical Sciences, New Delhi, India. dr_rahul6@hotmail.com
Tyagi
Seema
S
Choudhry
Ved Prakash
VP
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011237:Predictive Value of Tests; D055728:Primary Myelofibrosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D035583:Rare Diseases; D012074:Remission Induction; D012189:Retrospective Studies; D018232:Rhabdomyosarcoma, Alveolar / Q000150:complications* / Q000556:secondary; D016896:Treatment Outcome
D008775:Methylprednisolone