Hepatocarcinoma in viral and metabolic liver disease.
It is becoming increasingly evident that children, like adults, with chronic viral or metabolic liver diseases are at risk for the development of hepatocarcinoma. The aims of this article are to review the risk factors for hepatocarcinoma in chronic viral or metabolic liver disease, outline potential pathogenic mechanisms of hepatocarcinoma, and describe surveillance strategies, clinical evaluation, and management of hepatocarcinoma in children.
Rosenthal
Philip
P
University of California, San Francisco, 94143-0136, USA. prosenth@peds.ucsf.edu
D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002908:Chronic Disease; D006525:Hepatitis, Viral, Human / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000378:metabolism / Q000821:virology; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D015995:Prevalence; D012307:Risk Factors; D018571:Sentinel Surveillance; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage*
D014761:Viral Hepatitis Vaccines