title: Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet.
abstract: Maternal stress and malnutrition modify intrauterine fetal development with impact on postnatal blood pressure, nutrient, water, and electrolyte metabolism. The present study explored the possible involvement of maternal serum- and glucocorticoid-inducible kinase (SGK)-1 in fetal programming of blood pressure. To this end, wild-type (sgk1(+/+)) male mice were mated with SGK1 knockout (sgk1(-/-)) female mice, and sgk1(-/-) males with sgk1(+/+) females, resulting in both cases in heterozygotic (sgk1(-/+)) offspring. Following prenatal protein restriction, the offspring of sgk1(+/+) mothers gained weight significantly slower and had significantly higher blood pressure after birth. Moreover, a sexual dimorphism was apparent in fasting blood glucose and plasma corticosterone concentrations, with higher levels in female offspring. In contrast, prenatal protein restriction of sgk1(-/-) mothers had no significant effect on postnatal weight gain, blood pressure, plasma glucose concentration, or corticosterone levels, irrespective of offspring sex. Plasma aldosterone concentration, urinary flow rates, and urinary excretions of Na(+) and K(+) were not significantly modified by either maternal genotype or nutritional manipulation. In conclusion, maternal signals mediated by SGK1 may play a decisive role in fetal programming of hypertension induced by prenatal protein restriction.
authors: Department of Physiology, University of Tübingen, Gmelinstrasse 5, Tübingen, Germany.
authors: Rexhep
authors: R
authors: Rexhepaj
authors: Krishna M
authors: KM
authors: Boini
authors: Dan Yang
authors: DY
authors: Huang
authors: Kerstin
authors: K
authors: Amann
authors: Ferruh
authors: F
authors: Artunc
authors: Kan
authors: K
authors: Wang
authors: Jan J
authors: JJ
authors: Brosens
authors: Dietmar
authors: D
authors: Kuhl
authors: Florian
authors: F
authors: Lang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D003345:Corticosterone / Q000097:blood; D004044:Dietary Proteins; D004435:Eating / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000235:genetics / Q000502:physiology*; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011188:Potassium / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics / Q000503:physiopathology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D012727:Sex Characteristics; D012964:Sodium / Q000378:metabolism; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D001786:Blood Glucose; D003345:Corticosterone; D004044:Dietary Proteins; D017874:Immediate-Early Proteins; D011188:Potassium; D017346:Protein Serine-Threonine Kinases; D012964:Sodium; D000099184:Serum-Glucocorticoid Regulated Kinases