[Effect of phospholipid on absorption of diammonium glycyrrhizinate].
To investigate the absorption mechanism of diammonium glycyrrhizinate (GL) for oral use in rat intestine as well as the effect of phospholipids on GL and its metabolite glycyrrhetic acid (GA), in situ single pass intestinal perfusion model and the rat single-pass intestinal perfusion with mesenteric cannulation model were used and the concentrations of GL and GA in perfusate and blood were determined by HPLC. The apparent permeability values (Papp) of GA with or without phospholipids are 7.98 and 5.73 cm x min(-1), respectively, whereas the permeability of GL had no significant statistical difference. The results showed that phospholipids can increase the absorption extent and speed of GA. This action can be used in the research and development of the new drugs of the glycyrrhiza.
Zhou
Liang
L
Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Yang
Jin
J
Zhang
Xue-Ying
XY
Liu
Xiao-Quan
XQ
Wang
Guang-Ji
GJ
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006034:Glycyrrhetinic Acid / Q000097:blood / Q000493:pharmacokinetics*; D019695:Glycyrrhizic Acid / Q000097:blood / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008642:Mesenteric Veins / Q000378:metabolism; D010477:Perfusion; D010743:Phospholipids / Q000494:pharmacology*; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D010743:Phospholipids; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid