title: Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.
abstract: Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug.
authors: Trius Therapeutics, Inc., 6310 Nancy Ridge Drive, Suite 105, San Diego, CA 92121, USA. kgc@triusrx.com
authors: G C
authors: GC
authors: Kedar
authors: Vickie
authors: V
authors: Brown-Driver
authors: Daniel R
authors: DR
authors: Reyes
authors: Mark T
authors: MT
authors: Hilgers
authors: Mark A
authors: MA
authors: Stidham
authors: Karen Joy
authors: KJ
authors: Shaw
authors: John
authors: J
authors: Finn
authors: Robert J
authors: RJ
authors: Haselbeck
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000235:genetics* / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001408:Bacillus anthracis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D005578:Fosfomycin / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D016372:RNA, Antisense; D005578:Fosfomycin; D019883:Alkyl and Aryl Transferases; C022566:UDP-N-acetylglucosamine 1-carboxyvinyltransferase