title: Prevalence of cypress pollen sensitization and its clinical importance in Izmir, Turkey, with cypress allergy assessed by nasal provocation.
abstract: OBJECTIVE
  Pollens from the Cupressaceae family are considered important allergens in the Mediterranean area, though reports of the prevalence of allergic symptoms have ranged from 1.04% to 35.4%. Our aim was to detect the prevalence of cypress pollen sensitization and determine its clinical importance in patients with seasonal respiratory allergy.
  
  
  METHODS
  We used skin prick tests (SPT) and serum specific IgE assays to reveal sensitization to cypress pollen. In patients who showed positive results to cypress pollen, a nasal provocation test (NPT) with pollen extract was used to assess the target organ response.
  
  
  RESULTS
  Sixty-five (14.3%) of 455 patients showed positive SPT responses to Cupressus sempervirens extract. Only 1 patient was monosensitized while 64 patients were polysensitized. Among those, 2 pollen cosensitizations were found to be significant (86% were cosensitized to grasses and 72% were cosensitized to olive (P < .001). Serum specific IgE to cypress pollen was measured in 50 of the 65 patients; findings were positive for 37. When these 37 patients underwent NPT with C sempervirens allergen extract, only the single monosensitized patient had a positive NPT.
  
  
  CONCLUSIONS
  A positive SPT to cypress pollen may not reflect the true prevalence of sensitization. We assume that in the absence of a positive NPT, positive SPT results might be related to the presence of cross-reactivity between pollen species.
authors: Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Turkey. aytul.sin@ege.edu.tr
authors: A Z
authors: AZ
authors: Sin
authors: R
authors: R
authors: Ersoy
authors: O
authors: O
authors: Gulbahar
authors: O
authors: O
authors: Ardeniz
authors: N M
authors: NM
authors: Gokmen
authors: A
authors: A
authors: Kokuludag
mesh_terms: D000328:Adult; D003429:Cross Reactions; D029781:Cupressus / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D009299:Nasal Provocation Tests; D011058:Pollen / Q000276:immunology*; D015995:Prevalence; D012882:Skin Tests