Congenital Langerhans cell histiocytosis mimicking a "blueberry muffin baby".
Congenital Langerhans cell histiocytosis (LCH) is a rare condition with great diversity. A case of congenital skin-only LCH presenting as a "blueberry muffin baby" with a spontaneous regression by the age of 8 months is reported here. New insights into clinical manifestations and prognosis, which is not uniformly positive, are discussed. A thorough examination and a careful follow-up should be provided to these patients. Systemic therapy is warranted in multi-system disease; no consensus on treatment exists in case of LCH isolated to skin. The diagnosis of congenital self-healing LCH should be made only retrospectively.
Sankilampi
Ulla
U
Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. ulla.sankilampi@kuh.fi
Huikko-Tarvainen
Sari
S
Kärjä
Vesa
V
Pirinen
Elina
E
Naukkarinen
Anita
A
Hollmén
Antero
A
D000212:Acyclovir / Q000008:administration & dosage; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D010400:Penicillin G / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011379:Prognosis; D035583:Rare Diseases; D012075:Remission, Spontaneous; D012871:Skin Diseases / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D014031:Tobramycin / Q000008:administration & dosage
D010400:Penicillin G; D014031:Tobramycin; D000212:Acyclovir