Transforming growth factor beta suppresses beta-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner.
Transforming growth factor beta (TGFbeta) suppresses the malignant phenotype of human colon carcinoma cells through diverse cellular pathways. Activation of beta-catenin/Wnt signal pathway underlies the malignant phenotype of human colon carcinomas. The Smad family of signal transducing, sequence-specific transcription activators are mediators of TGFbeta signaling. In this report, we showed that TGFbeta suppressed the beta-catenin/Wnt signal pathway in human colon carcinoma cells and stimulated an adhesion response in these cells in a Smad4/DPC4 independent manner. Smad/DCP4, however, was found to be linked to the growth-inhibitory action of TGFbeta.
Wang
Huijun
H
Pathology Research Center, Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.
Rajan
Shanthi
S
Liu
Guangming
G
Chakrabarty
Subhas
S
D002448:Cell Adhesion / Q000502:physiology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000378:metabolism*; D006801:Humans; D018613:Microscopy, Confocal; D015398:Signal Transduction / Q000502:physiology*; D051901:Smad4 Protein / Q000378:metabolism; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
C497796:SMAD4 protein, human; D051901:Smad4 Protein; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; D051176:beta Catenin