[Inflammatory response in elderly patients with bacteremia].
OBJECTIVE
To evaluate inflammatory markers (C reactive protein [CRP], interleukina-1beta [IL-1beta], IL-6 and tumoral necrosis factor [TNF-alpha]) as predictors of bloodstream infection in elderly patients with systemic inflammatory response syndrome (SIRS).


METHODS
Blood cultures and markers were performed at admission and on day 4.


RESULTS
Eighty-two patients were included, 34% with positive blood cultures. TNF-alpha and IL-6 values at admission were higher in patients with positive blood cultures (84.5 vs. 28.5 pg/mL [P = .001] and 192.5 vs. 113, [P = .017], respectively). TNF-alpha values on day 4 were higher in patients with positive cultures (50.5 vs. 30; P = .017).


CONCLUSIONS
High TNF-alpha and IL-6 values at admission, and TNF-alpha values on day 4 correlated with bloodstream infection.
Martí
Luis
L
Servicio de Infecciones, Hospital Clínico-IDIBAPS, Universidad de Barcelona, Barcelona, Spain.
Cervera
Carlos
C
Filella
Xavier
X
Marín
José Luis
JL
Almela
Manel
M
Gatell
José M
JM
Moreno
Asunción
A
D000368:Aged; D016470:Bacteremia / Q000097:blood* / Q000150:complications; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein