Actin-binding toxin "tail" wags the dog.
Actin-binding marine macrolides exhibit significant structural and functional diversity. In this issue, Perrins et al. demonstrate that a long stereochemically conserved aliphatic side chain, known as the "tail", found in many of these compounds is the functional determinant of cytotoxicity (Perrins et al., 2008).
Tanaka
Junichi
J
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Okinawa 903-0213, Japan.
Blain
J Craig
JC
Allingham
John S
JS
D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D000199:Actins; D001688:Biological Products; D003603:Cytotoxins; D018942:Macrolides