title: A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists.
abstract: BACKGROUND
  Therapeutic biologic agents are uncommonly associated with lymphoma.
  
  
  METHODS
  We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva) and etanercept (Enbrel), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymphoma clinically and pathologically. Lymphocytosis and lymphadenopathy spontaneously remitted following cessation of etanercept therapy and have not recurred.
  
  
  CONCLUSIONS
  Distinction between clinically benign lymphoid proliferations related to anti-psoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy.
authors: Department of Dermatology, Saint Louis University School of Medicine, St Louis, MO, USA. yadirahr@yahoo.com
authors: M Yadira
authors: MY
authors: Hurley
authors: Mary Noel
authors: MN
authors: George
authors: Craig L
authors: CL
authors: Leonardi
authors: John L
authors: JL
authors: Frater