title: Comparative genomics-based prediction of protein function.
abstract: The era of genomics has opened new possibilities for the computational prediction of protein function. In particular, the comparison of fully sequenced genomes allows us to investigate the so-called genomic context of a gene, which includes its chromosomal positioning relative to other genes as well as its evolutionary record among the genomes considered. This information can be exploited to find functionally interacting partners for a protein of unknown function and thus obtain information on the biological process in which it is playing a role. Such comparative genomics-based techniques are increasingly being used in the process of genome annotation and in the development of testable working hypothesis.
authors: Bioinformatics Department, CIPF, Valencia, Spain.
authors: Toni
authors: T
authors: Gabaldón
mesh_terms: D030562:Databases, Protein; D023281:Genomics; D010802:Phylogeny; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D016415:Sequence Alignment
chemical_list: D011506:Proteins