[Significance of determination of gamma-interferon in the diagnosis of tuberculous exudative pleurisy].
The pleural fluid concentration of gamma-interferon (gamma-IFN) was studied in 44 patients with exudative pleurisy. The tuberculous nature of exudative pleurisy was established in 25 patients on the basis of X-ray study, a follow-up, microbiological study of pleural exudate specimens, and morphological studies of biopsy specimens obtained at video-assisted thoracoscopy or surgery. The the pleural exudate concentrations of gamma-IFN were over 300 pg/ml (mean 1019 +/- 161 pg/ml) in 19 out of 21 patients with exudative pleuritis in a phase of active inflammation. The patients with the fibrous outcome of pleurisy of tuberculous etiology and those with exudative pleurisy of non-tuberculous etiology, including that in malignancies and papapneumonic pleurisy, were observed to have lower concentrations of gamma-IFN (mean 118 +/- 16 pg/ml). With the discriminating level of above 300 pg/ml, the sensitivity and specificity of the test were 90.5 and 100%, respectively.
Darenskaia
S D
SD
Makarova
N V
NV
Vladimirskiĭ
M A
MA
Borisov
S E
SE
Emel'ianov
M N
MN
Kol'tsov
K I
KI
Efremov
E E
EE
Ignashenkova
G V
GV
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D012720:Severity of Illness Index; D014396:Tuberculosis, Pleural / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*
D007371:Interferon-gamma