[A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia].
Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine.
Lee
Ji Yeon
JY
Korea University Medical College Guro Hospital, Department of Internal Medicine, Seoul, Korea.
Park
Eun Bum
EB
Ahn
Jae Hong
JH
Suh
Sang-jun
SJ
Jung
Young Kul
YK
Kim
Ji Hoon
JH
Shin
Bong Kyung
BK
Yang
Jin Hyuk
JH
Yeon
Jong Eun
JE
Byun
Kwan Soo
KS
D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013988:Ticlopidine / Q000009:adverse effects*
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine