title: Cisplatin and gemcitabine in the management of metastatic penile cancer.
abstract: Penile cancer is rare and receives little public attention. There are few treatment options for advanced disease. The most active regimen to date is a combination of bleomycin, methotrexate, and cisplatin. However the treatment-related mortality is 11% and hence this combination has not been adapted as a standard of care. We report two cases of advanced penile cancer where a sustained palliative response was observed with combination chemotherapy using cisplatin and gemcitabine. Our experience demonstrates that this is a well tolerated regimen active in this setting.
authors: Department of Medical Oncology, St. James's Hospital, Dublin, Ireland. drdgpower@gmail.com
authors: Derek G
authors: DG
authors: Power
authors: David J
authors: DJ
authors: Galvin
authors: Sinead
authors: S
authors: Cuffe
authors: Gerald P
authors: GP
authors: McVey
authors: Paul J
authors: PJ
authors: Mulholland
authors: Cormac
authors: C
authors: Farrelly
authors: David W
authors: DW
authors: Delaney
authors: Kenneth J
authors: KJ
authors: O'Byrne
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010412:Penile Neoplasms / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D001761:Bleomycin; D002945:Cisplatin; D008727:Methotrexate; D000093542:Gemcitabine