title: Karyotyping twins in early pregnancy loss: a novel approach of obtaining specimens to avoid maternal contamination.
abstract: OBJECTIVE
  To test for chromosomal abnormalities in a missed abortion involving a twin gestation.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University-based infertility practice.
  
  
  METHODS
  A 37-year-old G3P0030 with recurrent abortions presented with a fourth missed abortion involving a twin gestation in the first trimester.
  
  
  METHODS
  Under anesthesia, hysteroscopy was performed and specimens obtained for karyotyping from each twin.
  
  
  METHODS
  Karyotype of each twin.
  
  
  RESULTS
  The karyotype of the conceptus on the left was 46,XY and that on the right was 46,XX.
  
  
  CONCLUSIONS
  Direct hysteroscopic biopsies can successfully differentiate the karyotypes of each twin of a missed abortion.
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, Michigan 48201, USA. niyiawonuga@aol.com
authors: Awoniyi O
authors: AO
authors: Awonuga
authors: Mazen E
authors: ME
authors: Abdallah
authors: Elizabeth E
authors: EE
authors: Puscheck
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000030:Abortion, Missed / Q000235:genetics*; D000328:Adult; D001706:Biopsy; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D005865:Gestational Age; D006801:Humans; D015907:Hysteroscopy; D007621:Karyotyping; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000235:genetics*; D013048:Specimen Handling / Q000379:methods*; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins / Q000235:genetics*