title: Cervical chondroid chordoma in a Shetland sheep dog.
abstract: A spayed female Shetland sheep dog aged 12 years was presented for examination with ataxia and hindlimb paralysis. Extradural spinal cord compression was found at the level of vertebrae C6-C7 by radiography and myelocomputed tomography. A jelly-like mass (0.6 x 1.3 cm) was removed surgically. Histopathological findings were characterized by proliferation of vacuolated polygonal cells (physaliphorous cells) in a mucinous matrix and the presence of chondroid tissue shown immunohistochemically to express S-100. The physaliphorous cells were immunolabelled strongly for vimentin and S-100, and weakly for cytokeratin. A diagnosis of canine cervical chondroid chordoma was made. This is considered to be the first report of a chondroid chordoma originating from the cervical region of the spine in the dog.
authors: Pathology Lab, Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service, 480 Anyang 6-dong, Manan-gu, Anyang-si, Gyeonggi 430-824, Republic of Korea. ghwoo@naver.com <ghwoo@naver.com>
authors: G H
authors: GH
authors: Woo
authors: E J
authors: EJ
authors: Bak
authors: Y W
authors: YW
authors: Lee
authors: H
authors: H
authors: Nakayama
authors: N
authors: N
authors: Sasaki
authors: K
authors: K
authors: Doi
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002574:Cervical Vertebrae / Q000473:pathology*; D002817:Chordoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D009192:Myelography / Q000662:veterinary; D010503:Periodic Acid-Schiff Reaction / Q000662:veterinary; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D013125:Spinal Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor