Evolutionary plasticity of genetic interaction networks.
Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.
Tischler
Julia
J
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.
Lehner
Ben
B
Fraser
Andrew G
AG
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D017353:Gene Deletion; D053263:Gene Regulatory Networks; D005804:Genes, Lethal; D008957:Models, Genetic; D010641:Phenotype; D025941:Protein Interaction Mapping; D034741:RNA, Small Interfering / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D034741:RNA, Small Interfering; D029701:Saccharomyces cerevisiae Proteins