title: Effects of Psoralea corylifolia on the cAMP-responsive element modulator (CREM) expression and spermatogenesis in rats.
abstract: OBJECTIVE
  Psoralea corylifolia (PC) is a medicinal herb used to improve male reproductive function in Korean traditional medicine. It has been used for treatment of male infertility including sexual dysfunction by improving kidney function.
  
  
  METHODS
  To investigate the effect of PC on spermatogenesis, the cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, the reverse-transcription polymerase chain reaction, and Western blot analysis. PC was administered to 10-week-old male Wistar rats for 56 consecutive days, the sperm formation period of the rat.
  
  
  CONCLUSIONS
  The PC-treated rats had increased sperm counts with enhanced levels of CREM messenger RNA and protein, suggesting that PC induces spermatogenesis via CREM activation in rat testes.
authors: Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Woong Mo
authors: WM
authors: Yang
authors: Mun Seog
authors: MS
authors: Chang
authors: Seong Kyu
authors: SK
authors: Park
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D015153:Blotting, Western; D001835:Body Weight / Q000187:drug effects; D051786:Cyclic AMP Response Element Modulator / Q000096:biosynthesis* / Q000235:genetics; D003520:Cyclophosphamide / Q000494:pharmacology; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D009929:Organ Size / Q000187:drug effects; D029907:Psoralea / Q000737:chemistry*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018076:DNA, Complementary; D012333:RNA, Messenger; D051786:Cyclic AMP Response Element Modulator; D003520:Cyclophosphamide