Nanomanipulation and nanotechnology for future diagnostics.
Nanomanipulation is a technology to manipulate a small object sized in nanometer to submicron scale. Optical tweezers is one of nanomanipulation techniques, which can investigate pico-newton to femto-newton force exerted on microscopic objects. We have developed a cell palpation system by use of optical tweezers and performed palpation experiments on cells. With the cell palpation system, an operator manipulates a probe particle to touch a certain location of a cell and feels the strength of the cell by hand through a haptic device, which displays force calculated and generated by a computer. We expect this technique can be used in diagnostic purpose and utilized not only in research field but also in daily medicine.
Sugiura
Tadao
T
Department of Genomics and Informatics, Nara Institute of Science and Technology, Japan. sugiura@is.naist.jp
Nakao
Megumi
M
Sato
Tetsuo
T
Minato
Kotaro
K
D002468:Cell Physiological Phenomena; D006801:Humans; D008846:Micromanipulation / Q000295:instrumentation*; D018625:Microscopy, Atomic Force; D036103:Nanotechnology / Q000295:instrumentation*; D052898:Optical Tweezers; D010173:Palpation