title: Calf muscles at blood oxygen level-dependent MR imaging: aging effects at postocclusive reactive hyperemia.
abstract: OBJECTIVE
  To prospectively investigate age-related changes in muscle reperfusion by using blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging of the calf in young and elderly healthy volunteers during postocclusive reactive hyperemia.
  
  
  METHODS
  Institutional review board approval and informed consent were obtained. Eleven healthy elderly (mean age, 64.0 years +/- 6.4 [standard deviation]; six men, five women) and 17 healthy young volunteers (mean age, 30.3 years +/- 6.5; seven men, 10 women) underwent muscle BOLD MR imaging of the calf. A fat-suppressed T2*-weighted single-shot multiecho echo-planar imaging sequence was used. Temporary vascular occlusion was induced with suprasystolic cuff compression of the thigh. T2* time courses of the muscle BOLD MR signal intensity were obtained from four calf muscles and were characterized by the following curve parameters: hyperemia peak value, time to peak, and T2* end value after 360 seconds of hyperemia. Differences in these parameters between the two cohorts were assessed by using a Student t test.
  
  
  RESULTS
  Considerably lower T2* maxima were observed in the elderly group during hyperemia (P < .005), with a mean hyperemia peak value of 13.1% +/- 3.0 compared with 18.9% +/- 4.8 in young healthy adults. Peaking occurred earlier in the elderly group (P < .05), with a mean time to peak of 32.2 seconds +/- 10.6 compared with 43.1 seconds +/- 10.7 in young adults. Furthermore, the elderly group had a significantly slower decrease of the muscle BOLD signal after the hyperemia peak (P < .001), which led to a higher end value of 8.6% +/- 3.0 compared with 2.6% +/- 2.1 in the young group.
  
  
  CONCLUSIONS
  BOLD MR imaging results of the calf demonstrated statistically significant age-dependent differences in the rate, intensity, and recovery of the postocclusive muscle BOLD signal.
authors: Biocenter, University of Basel, Basel, Switzerland.
authors: Anja-Carina
authors: AC
authors: Schulte
authors: Markus
authors: M
authors: Aschwanden
authors: Deniz
authors: D
authors: Bilecen
mesh_terms: D000367:Age Factors; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply*; D010100:Oxygen / Q000378:metabolism*; D016491:Peripheral Vascular Diseases / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D010100:Oxygen