title: [New progress in crystallization technology of membrane protein and introduction of pharamaceutical innovation value chain].
abstract: We have recently established a Pharamaceutical Innovation Value Chain in collaboration with the SOSHO project (http://www.so-sho.jp) and BioGrid Project (http://www.biogrid.jp/) to accelerate new drug development. The SOSHO project provides novel crystallization technology with laser-irradiation and stirring growth methods, and the BioGrid Project is developing the software necessary for the in silico screening of promising drugs and the simulation of biological responses to proteins. In this paper, we report the recent research work on the crystallization of membrane proteins and the development of a method for in silico drug discovery.
authors: Graduate School of Engineering Osaka University, Yamada-Oka, Suita City, Japan. inouet@chem.eng.osaka-u.ac.jp
authors: Tsuyoshi
authors: T
authors: Inoue
authors: Hiroaki
authors: H
authors: Adachi
authors: Satoshi
authors: S
authors: Murakami
authors: Kazufumi
authors: K
authors: Takano
authors: Hiroyoshi
authors: H
authors: Matsumura
authors: Yusuke
authors: Y
authors: Mori
authors: Yoshifumi
authors: Y
authors: Fukunishi
authors: Haruki
authors: H
authors: Nakamura
authors: Takayoshi
authors: T
authors: Kinoshita
authors: Isao
authors: I
authors: Nakanishi
authors: Yasushi
authors: Y
authors: Okuno
authors: Satoshi
authors: S
authors: Minakata
authors: Shinji
authors: S
authors: Shimojo
authors: Tsuneaki
authors: T
authors: Sakata
mesh_terms: D000818:Animals; D003460:Crystallization / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D007834:Lasers; D008565:Membrane Proteins; D012984:Software; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D008565:Membrane Proteins