title: Tibolone: the way to beat many a postmenopausal ailments.
abstract: OBJECTIVE
  The effects of tibolone on climacteric symptoms, osteoporosis, cardiovascular disease, breasts and the endometrium are summarised, and its role in clinical practice is reviewed in this article.
  
  
  BACKGROUND
  Tibolone has tissue-specific effects on receptors and enzymes that influence the synthesis and metabolism of endogenous sexual steroid hormones.
  
  
  METHODS
  This evaluation was based on the findings from several randomised studies, which addressed the basic and clinical research on tibolone.
  
  
  CONCLUSIONS
  Clinical trials prove that tibolone is effective in the treatment of the menopausal symptoms and for the postponement and calming of symptoms accompanying age-related diseases. The findings of basic researchers that tibolone affects the metabolism of every cell, including malignant cells, opened a door to a whole new domain of research that has a promising future.
authors: Institute of Gynecology and Obstetrics of the Clinical Centre of Serbia, 11000 Belgrade, Serbia and Montenegro. lazovicg@eunet.yu
authors: Gordana
authors: G
authors: Lazovic
authors: Ubavka
authors: U
authors: Radivojevic
authors: Jelena
authors: J
authors: Marinkovic
mesh_terms: D001943:Breast Neoplasms / Q000139:chemically induced; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002979:Climacteric / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects / Q000503:physiopathology; D020847:Estrogen Receptor Modulators / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000502:physiology; D009652:Norpregnenes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000517:prevention & control; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020521:Stroke / Q000139:chemically induced
chemical_list: D020847:Estrogen Receptor Modulators; D004967:Estrogens; D009652:Norpregnenes; C027385:tibolone