title: Professional challenges in cancer genetic testing: who is the patient?
abstract: In the genetic counseling setting, the health care provider can be challenged by opposing duties to members of the same family: protecting the privacy of the patient identified with a gene mutation and the ethical obligation to warn at-risk relatives. In a situation of nondisclosure between members of a family with a known disease-predisposing mutation, this type of dilemma can present in acute form for the provider who cares for different members of the family. This can hinder effective medical decision making. To minimize this effect, we recommend detailed pretest genetic counseling steps to empower the patient to communicate with their at-risk relatives their intent to pursue testing and willingness to share information. In addition, post-test counseling should reiterate the implications of a positive result for at-risk relatives and conclude with a written summary that patients can share with their family.
authors: Massachusetts General Hospital Cancer Center/Center for Cancer Risk Assessment, Boston, MA 02114, USA. gchansmutko@partners.org
authors: Gayun
authors: G
authors: Chan-Smutko
authors: Devanshi
authors: D
authors: Patel
authors: Kristen M
authors: KM
authors: Shannon
authors: Paula D
authors: PD
authors: Ryan
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000517:prevention & control; D003142:Communication; D003219:Confidentiality; D003220:Conflict, Psychological; D004268:DNA-Binding Proteins / Q000235:genetics; D017007:Duty to Warn; D005260:Female; D018703:Founder Effect; D019398:Genes, BRCA1; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007585:Jews; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000517:prevention & control; D010375:Pedigree
chemical_list: D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein