title: Anaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization.
abstract: Methotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy for ALL. A desensitization protocol was followed and MTX tolerance has been successfully achieved, allowing this patient to complete the needed chemotherapy.
authors: Department of Paediatrics, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal.
authors: Teresa
authors: T
authors: Caldeira
authors: Vitor
authors: V
authors: Costa
authors: Isabel
authors: I
authors: Silva
authors: Tereza
authors: T
authors: Oliva
authors: Lucília
authors: L
authors: Norton
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects*; D002648:Child; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000628:therapy*; D006801:Humans; D007278:Injections, Spinal; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate