title: Onychomycosis incidence in type 2 diabetes mellitus patients.
abstract: The onychomycosis incidence was determined in 250 type 2 diabetes mellitus (T2DM) patients who were registered at the Internal Medicine Service from a Mexico city General Hospital throughout a year (January-December 2006). Out of the total of studied T2DM patients, 93 (37.2%) showed ungual dystrophy and from these, in 75.3% a fungal etiology was corroborated. Out of 70 patients, 34 were men and 36 women, with an average of 63.5 years. Correlation between T2DM evolution time and onychomycosis was significant (P < 0.01). Distal-lateral subungual and total dystrophic onychomycosis were the most frequent clinical types (55.1% and 33.7%, respectively). Fifty-eight fungal isolates were obtained; 48.6% corresponded to dermatophytes, Trichophyton rubrum being the first species (37.1%). All these strains corresponded to two morphological varieties: "yellow" and typical downy. From the yeast-like isolates, 12 corresponded to Candida spp., firstly C. albicans and C. parapsilosis; three to Cryptococcus spp. (C. albidus, C. uniguttulatus and C. laurentii); two Trichosporon asahii; and only one to Pichia ohmeri. Six non-dermatophytic molds were isolated: two Chrysosporium keratinophylus, two Scopulariopsis brevicaulis, one Aspergillus fumigatus, and one Acremonium sp. The fungal mixture corresponded to T. mentagrophytes with C. guilliermondii; T. mentagrophytes with C. glabrata; T. rubrum with C. glabrata; T. rubrum with P. ohmeri.
authors: Laboratorio de Micología Médica, Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, Ciudad Universitaria, Mexico, CP 04510, DF, Mexico. angelesmg@liceaga.facmed.unam.mx
authors: Patricia
authors: P
authors: Manzano-Gayosso
authors: Francisca
authors: F
authors: Hernández-Hernández
authors: Luis Javier
authors: LJ
authors: Méndez-Tovar
authors: Yanni
authors: Y
authors: Palacios-Morales
authors: Erika
authors: E
authors: Córdova-Martínez
authors: Elva
authors: E
authors: Bazán-Mora
authors: Rubén
authors: R
authors: López-Martinez
mesh_terms: D000368:Aged; D003883:Arthrodermataceae / Q000302:isolation & purification; D002175:Candida / Q000302:isolation & purification; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005533:Foot Dermatoses / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D005658:Fungi / Q000302:isolation & purification; D006229:Hand Dermatoses / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D014009:Onychomycosis / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology; D014249:Trichophyton / Q000302:isolation & purification; D015003:Yeasts / Q000302:isolation & purification