Management of hypertension in patients with left ventricular hypertrophy.
Left ventricular hypertrophy (LVH) is a cardinal manifestation of organ damage in patients with arterial hypertension. Identifying LVH is a fundamental step in evaluating hypertensive patients, because clinical and epidemiologic studies have shown this condition has a strong independent adverse prognostic significance. LVH is an integrated marker of cardiovascular risk, reflecting hypertension's hemodynamic and nonhemodynamic effects on the heart. Reversing LVH is an intermediate goal of antihypertensive therapy. Pharmacologic strategies to reverse LVH should be based on combining two or more drugs: a renin-angiotensin system blocker (ie, angiotensin-converting enzyme inhibitor or angiotensin receptor antagonist), and a calcium antagonist or low-dose diuretic. Successful therapeutic plans should also include nonpharmacologic interventions to promote LVH regression.
Cuspidi
Cesare
C
Policlinico di Monza, Via Amati 111, 20052 Monza, Italy. cesare.cuspidi@unimib.it
Sala
Carla
C
Zanchetti
Alberto
A
D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D015995:Prevalence; D012307:Risk Factors
D000959:Antihypertensive Agents