Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model.
The wild-type baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects a range of mammalian cell types in vitro but does not replicate in these cells. The current study investigated the in vivo effect of AcMNPV in the mouse model of liver cirrhosis induced by the mutagen dimethylnitrosamine. Intraperitoneal injection of AcMNPV induced an immune response. The baculovirus was taken up by the liver and spleen where it suppressed liver injury and fibrosis through the induction of interferons. This study presents the first evidence of the feasibility of using baculovirus to treat liver cirrhosis.
Nishibe
Y
Y
Department of Life and Environmental Science, Chiba Institute of Technology, Chiba, Japan.
Kaneko
H
H
Suzuki
H
H
Abe
T
T
Matsuura
Y
Y
Takaku
H
H
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D003094:Collagen / Q000032:analysis; D004128:Dimethylnitrosamine; D005260:Female; D017228:Hepatocyte Growth Factor / Q000235:genetics; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology*; D008099:Liver / Q000276:immunology* / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000276:immunology / Q000628:therapy* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D017924:Nucleopolyhedroviruses / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000821:virology; D014162:Transfection / Q000379:methods; D016212:Transforming Growth Factor beta / Q000235:genetics
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D017228:Hepatocyte Growth Factor; D007371:Interferon-gamma; D003094:Collagen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D004128:Dimethylnitrosamine