title: New gadolinium complex with efficient hydrolase-like activity: a 100-million-fold rate enhancement in diester hydrolysis.
abstract: The synthesis, structure, and hydrolase-like catalytic activity of a new mononuclear gadolinium complex [Gd(L)(NO3)(H2O)3](NO3)2 (1) are reported. A clean two-stage kinetic reaction for hydrolysis of the diester 2,4-bis(dinitrophenyl)phosphate by 1 was followed, and the rate constants were determined. A high DNA cleavage activity was also demonstrated. The active species in the hydrolytic process is proposed based on the X-ray structure, electrospray ionization mass spectrometry analysis, and kinetic and potentiometric equilibrium studies of 1.
authors: Laboratório de Bioinorgânica e Cristalografia (LABINC), Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil.
authors: Maryene A
authors: MA
authors: Camargo
authors: Ademir
authors: A
authors: Neves
authors: Adailton J
authors: AJ
authors: Bortoluzzi
authors: Bruno
authors: B
authors: Szpoganicz
authors: Adriano
authors: A
authors: Martendal
authors: Michael
authors: M
authors: Murgu
authors: Franciele L
authors: FL
authors: Fischer
authors: Hernán
authors: H
authors: Terenzi
authors: Patricia Cardoso
authors: PC
authors: Severino
mesh_terms: D002384:Catalysis; D005682:Gadolinium; D006867:Hydrolases / Q000737:chemistry / Q000378:metabolism*; D006868:Hydrolysis; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D005682:Gadolinium; D006867:Hydrolases