Structural features of antitumor titanium agents and related compounds.
Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization.
Caruso
Francesco
F
Instituto di Chimica Biomolecolare, CNR, Piazzale Aldo Moro, 5, Rome 00185, Italy. francesco.caruso@icb.cnr.it
Rossi
Miriam
M
Opazo
Cristian
C
Pettinari
Claudio
C