title: Staying alive: bacterial inhibition of apoptosis during infection.
abstract: The ability of bacterial pathogens to inhibit apoptosis in eukaryotic cells during infection is an emerging theme in the study of bacterial pathogenesis. Prevention of apoptosis provides a survival advantage because it enables the bacteria to replicate inside host cells. Bacterial pathogens have evolved several ways to prevent apoptosis by protecting the mitochondria and preventing cytochrome c release, by activating cell survival pathways, or by preventing caspase activation. This review summarizes the most recent work on bacterial anti-apoptotic strategies and suggests new research that is necessary to advance the field.
authors: Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA.
authors: Christina S
authors: CS
authors: Faherty
authors: Anthony T
authors: AT
authors: Maurelli
mesh_terms: D000818:Animals; D017209:Apoptosis; D001419:Bacteria / Q000254:growth & development* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D002460:Cell Line; D045304:Cytochromes c / Q000037:antagonists & inhibitors / Q000378:metabolism; D005057:Eukaryotic Cells / Q000382:microbiology* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D051381:Rats
chemical_list: D061945:Caspase Inhibitors; D045304:Cytochromes c; D020169:Caspases