Foamy histiocytes in a patient with visceral leishmaniasis after treatment with liposomal amphotericin B.
A seven-year-old patient was admitted to our hospital with the complaints of fever, malaise, and abdominal distention. In the bone marrow aspiration smears, leishmania amastigotes were observed. The patient was diagnosed as having visceral leishmaniasis (VL) and treated with liposomal amphotericin B (L-AMB). The authors report their observation of foamy histiocytes seen in the bone marrow aspiration smears of the patient with VL after L-AMB treatment. This effect of L-AMB needs to be recognized, since L-AMB may represent a further condition in addition to the other diseases that are associated with foamy histiocytes in the bone marrow.
Tavil
Betül
B
Unit of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Seçmeer
Gülten
G
Ozen
Hasan
H
Cengiz
Ali Bülent
AB
Unal
Sule
S
Gürgey
Aytemiz
A
D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects*; D001856:Bone Marrow Examination; D002648:Child; D005487:Foam Cells / Q000187:drug effects*; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male
D000981:Antiprotozoal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B