Inhibition of vein graft intimal hyperplasia by periadventitial application of hyaluronic acid-carboxymethyl cellulose: an experimental study.
OBJECTIVE
Placement of an external support has been reported to prevent intimal hyperplasia of vein grafts. In this study, we investigated the effect of HA/CMC on intimal hyperplasia in a rabbit model.


METHODS
Right jugular vein to common carotid artery bypass grafting was performed in 24 female New Zealand white rabbits (2.5-3.0 kg). Animals were divided into two groups: control group (n=12) and HA/CMC group (n=12). Absorbable membrane barrier was wrapped around vein grafts in HA/CMC group. In control group, no material was applied following venous graft bypass.


RESULTS
At 1 month, in the vein grafts supported with the HA/CMC membrane neointimal thickening was significantly less (109 microm [IQR, 78-166]) compared to the unsupported control grafts (220 microm [IQR; 101-312]; p<0.001). Medial thickening in the HA/CMC group (128 microm [IQR, 101-181]) compared to unsheathed control grafts (182 microm [IQR, 131-255] p<0.001) was also significantly less.


CONCLUSIONS
Periadventitial placement of HA/CMC as an absorbable membrane inhibits intimal hyperplasia of vein bypass grafts in a rabbit model.
Bahcivan
Muzaffer
M
Department of Cardiovascular Surgery, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey. mbahcivan33@yahoo.com
Yucel
Semih
S
Kefeli
Mehmet
M
Gol
M Kamil
MK
Can
Bilge
B
Keceligil
Hasan Tahsin
HT
D020341:Absorbable Implants; D000818:Animals; D017536:Carotid Artery, Common / Q000601:surgery; D004195:Disease Models, Animal; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D006965:Hyperplasia / Q000517:prevention & control; D007150:Immunohistochemistry; D007601:Jugular Veins / Q000637:transplantation*; D008567:Membranes, Artificial; D011817:Rabbits; D017539:Tunica Intima / Q000473:pathology*
D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid