title: X-inactivation: it takes two to count.
abstract: Mammals balance X-linked gene dosage by silencing one X chromosome in female cells, a process that begins with counting the number of X chromosomes. Recent reports suggest homologous X chromosome pairing may be a prerequisite for silencing, providing a basis for counting by ensuring that silencing only occurs in cells with two X chromosomes.
authors: Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA.
authors: Morgan
authors: M
authors: Royce-Tolland
authors: Barbara
authors: B
authors: Panning
mesh_terms: D000818:Animals; D005260:Female; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism*; D049951:X Chromosome Inactivation / Q000502:physiology*
chemical_list: D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C465658:Tsix transcript, mouse