title: The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.
abstract: Olfactory sensory neurons (OSNs) that express the same odorant receptor project their axons to specific glomeruli in the main olfactory bulb. Protocadherin-alpha (Pcdha) proteins, diverse cadherin-related molecules that are encoded as a gene cluster, are highly concentrated in OSN axons and olfactory glomeruli. Here, we describe Pcdha mutant mice, in which the constant region of the Pcdha gene cluster has been deleted by gene targeting. The mutant mice show abnormal sorting of OSN axons into glomeruli. There are multiple, small, extraneous glomeruli for the odorant receptors M71 and MOR23. These abnormal patterns of M71 and MOR23 glomeruli persist until adulthood. Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb.
authors: KOKORO-Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors: Sonoko
authors: S
authors: Hasegawa
authors: Shun
authors: S
authors: Hamada
authors: You
authors: Y
authors: Kumode
authors: Shigeyuki
authors: S
authors: Esumi
authors: Shota
authors: S
authors: Katori
authors: Emi
authors: E
authors: Fukuda
authors: Yasuo
authors: Y
authors: Uchiyama
authors: Takahiro
authors: T
authors: Hirabayashi
authors: Peter
authors: P
authors: Mombaerts
authors: Takeshi
authors: T
authors: Yagi
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D018390:Gene Targeting; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D005810:Multigene Family / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development*; D009833:Olfactory Pathways / Q000166:cytology / Q000254:growth & development*; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000254:growth & development*; D011956:Receptors, Cell Surface / Q000502:physiology*; D018035:Receptors, Odorant / Q000235:genetics / Q000502:physiology
chemical_list: D015820:Cadherins; C502656:Olfr151 protein, mouse; C118713:Olfr16 protein, mouse; D011956:Receptors, Cell Surface; D018035:Receptors, Odorant