Stem cell regulation and host defense: the logic and the paradox.
As a response against serious infection, there is often a need to produce more leukocytes to defend the organism against the infectious agent. In this issue of Cell Stem Cell, Goodell and colleagues (Feng et al., 2008) find a link between regulators of host defense and hematopoietic stem cells.
Karlsson
Göran
G
Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, BMC A12, Lund, 221 84, Sweden. stefan.karlsson@med.lu.se
Karlsson
Stefan
S
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D019204:GTP-Binding Proteins / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007109:Immunity; D051379:Mice
C096000:Ifi1 protein, mouse; D019204:GTP-Binding Proteins