Difficulties in diagnosis and management of ectopic Cushing syndrome.
A 18-year-old man presented to a local hospital with muscle weakness, facial edema, and a 6 kg weight gain over 2 months. After a complete work-up, he was diagnosed with pituitary Cushing syndrome and treated with a bilateral adrenalectomy for Cushing syndrome and pituitary radiotherapy for Nelson syndrome. Twenty-five years later, his ectopic source of adrenocorticotropic hormone was revealed as a pulmonary neuroendocrine tumor, and a pulmonary resection was performed. Subsequently, a biochemical and clinical remission including hyperpigmentation was achieved.
Cho
Sukki
S
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, 463-707 Gyeonggi-do, Korea.
Ra
Yong Joon
YJ
Lee
Choon-Taek
CT
Chung
Jin-Haeng
JH
Sung
Sook-Whan
SW
Jheon
Sanghoon
S
D000182:ACTH Syndrome, Ectopic / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D000293:Adolescent; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D008297:Male; D009347:Nelson Syndrome / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D049268:Positron-Emission Tomography
D000324:Adrenocorticotropic Hormone