Tightening of knots in proteins.
We perform theoretical studies of stretching of 20 proteins with knots within a coarse-grained model. The knot's ends are found to jump to well defined sequential locations that are associated with sharp turns, whereas in homopolymers they diffuse around and eventually slide off. The waiting times of the jumps are increasingly stochastic as the temperature is raised. Knots typically do not return to their native locations when a protein is released after stretching.
Sułkowska
Joanna I
JI
Institute of Physics, Polish Academy of Sciences, Aleja Lotników 32/46, 02-668 Warsaw, Poland.
Sułkowski
Piotr
P
Szymczak
P
P
Cieplak
Marek
M
D000465:Algorithms; D004058:Diffusion; D008958:Models, Molecular; D011487:Protein Conformation; D012997:Solvents; D013269:Stochastic Processes; D013696:Temperature
D012997:Solvents