title: Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate.
abstract: Transient myeloproliferative disorder seen in neonates with Down syndrome is often thought to have a benign course. The authors describe the clinical and laboratory profile of a neonate with Down phenotype and transient myeloproliferative disorder with pericardial effusion as co-morbidity. Pericardial fluid analysis showed eosinophils. Pericardial effusion resolved with prednisolone therapy. Regression in hepatosplenomegaly with clearance of blasts was seen by third week of illness. The clinical course suggested a benign infiltration of the pericardium. Presence of eosinophils supports the differentiating capability of the blast cells in transient myeloproliferative disorders.
authors: Department of Pediatrics, Kasturba Medical College, Mangalore, Karnataka, India. drshenoy2001@hotmail.com
authors: Rathika D
authors: RD
authors: Shenoy
authors: Kamalakshi G
authors: KG
authors: Bhat
authors: Nutan
authors: N
authors: Kamath
authors: Yusuf
authors: Y
authors: Kumble
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D004314:Down Syndrome / Q000150:complications* / Q000188:drug therapy; D004804:Eosinophils; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000188:drug therapy; D010490:Pericardial Effusion / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011239:Prednisolone