title: Leukemic transformation of Langerhans cell sarcoma.
abstract: A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of disease progression 7 months after the initial diagnosis. Tumor cells in the leukemic phase expressed CD5, CD7, CD13, CD33, CD34, CD68, and CD123. These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia.
authors: Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
authors: Kousuke
authors: K
authors: Sumida
authors: Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
authors: Yuya
authors: Y
authors: Yoshidomi
authors: Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
authors: Hiroko
authors: H
authors: Koga
authors: Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
authors: Nobuo
authors: N
authors: Kuwahara
authors: Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
authors: Eijo
authors: E
authors: Matsuishi
authors: Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
authors: Kennosuke
authors: K
authors: Karube
authors: Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
authors: Koichi
authors: K
authors: Oshima
authors: Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan. gondou@koseikan.jp.
authors: Hisashi
authors: H
authors: Gondo
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D054752:Langerhans Cell Sarcoma / Q000276:immunology / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D015703:Antigens, CD