[Reversible posterior leukoencephalopathy: report of two cases after vincristine treatment].
Reversible posterior leukoencephalopathy syndrome is a clinical-radiological phenomenon associated with headache, vomiting, lethargy, visual disturbances and seizures, concomitant with radiological abnormalities predominantly within posterior cerebral white matter due to cerebral edema. There are multiple triggers as acute hypertension, cancer, hematological disease, renal pathology, red cells transfusions and different drugs. We present two patients with reversible posterior leukoencephalopathy under treatment for acute lymphoblastic leukemia because of the probable association with vinca alkaloids.
Hualde Olascoaga
J
J
Unidad de Oncohematología Infantil, Servicio de Pediatría, Hospital Virgen del Camino, Pamplona, Spain.
Molins Castiella
T
T
Souto Hernández
S
S
Becerril Moreno
F
F
Yoldi Petri
M E
ME
Sagaseta de Ilurdoz
M
M
Molina Garicano
J
J
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic