Porous devices derived from co-continuous polymer blends as a route for controlled drug release.
In this study we examine the release profile of bovine serum albumin (BSA) from a porous polymer matrix derived from a co-continuous polymer blend. The porosity is generated through the selective extraction of one of the continuous phases. This is the first study to examine the approach of using morphologically tailored co-continuous polymer blends as a template for generating porous polymer materials for use in controlled release. A method for the preparation of polymeric capsules is introduced, and the effect of matrix pore size and surface area on the BSA release profile is investigated. Furthermore, the effect of surface charge on release is examined by surface modification of the porous substrate using layer-by-layer deposition techniques. Synthetic, nonerodible polymer, high-density polyethylene (HDPE), was used as a model substrate prepared by melt blending with two different styrene-ethylene-butylene copolymers. Blends with HDPE allow for the preparation of porous substrates with small pore sizes (300 and 600 nm). A blend of polylactide (PLA) and polystyrene was also used to prepare porous PLA with a larger pore size (1.5 microm). The extents of interconnectivity, surface area, and pore dimension of the prepared porous substrates were examined via gravimetric solvent extraction, BET nitrogen adsorption, mercury porosimetry, and image analysis of scanning electron microscopy micrographs. With a loading protocol into the porous HDPE and PLA involving the alternate application of pressure and vacuum, it is shown that virtually the entire porous network was accessible to BSA loading, and loading efficiencies of between 80% and 96% were obtained depending on the pore size of the carrier and the applied pressure. The release profile of BSA from the microporous structure was monitored by UV spectrophotometry. The influence of pore size, surface area, surface charge, and number of deposited layers is demonstrated. It is shown that an effective closed-cell structure in porous PLA can be prepared, effectively eliminating all short-term BSA release.
Salehi
Pouneh
P
CREPEC, Department of Chemical Engineering, Ecole Polytechnique de Montréal,PO Box 6079 Station Centre-ville, Montréal, (QC) Canada H3C 3A7.
Sarazin
Pierre
P
Favis
Basil D
BD
D000818:Animals; D002417:Cattle; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D020959:Polyethylene / Q000008:administration & dosage; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D016062:Porosity; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties
D011091:Polyesters; D011108:Polymers; D011137:Polystyrenes; D012710:Serum Albumin, Bovine; C033616:poly(lactide); D020959:Polyethylene; C024075:styrofoam