Secondary anaplastic oligodendroglioma after cranial irradiation: a case report.
Secondary brain tumors rarely arise after cranial irradiation; among them, meningiomas and glioblastomas are the most common and secondary oligodendroglial tumors the most rare. We present a 48-year-old man who developed an oligodendroglial tumor 38 years after receiving 50 Gy of cranial irradiation to a pineal tumor. He underwent gross total removal of a calcified, ring-enhanced mass in the right temporal lobe. The tumor was histologically diagnosed as anaplastic oligodendroglioma. Our review of previously reported secondary oligodendroglial tumors that developed after cranial irradiation revealed that these rare tumors arose after low-dose cranial irradiation or at the margin of a field irradiated with a high dose. We suggest that secondary oligodendroglial tumors arising after cranial irradiation are more aggressive than primary oligodendrogliomas.
Doskaliyev
Aidos
A
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Yamasaki
Fumiyuki
F
Kenjo
Masahiro
M
Shrestha
Prabin
P
Saito
Taiichi
T
Hanaya
Ryosuke
R
Sugiyama
Kazuhiko
K
Kurisu
Kaoru
K
D001932:Brain Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D016371:Cranial Irradiation / Q000009:adverse effects*; D015254:DNA Modification Methylases / Q000096:biosynthesis; D045643:DNA Repair Enzymes / Q000096:biosynthesis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000378:metabolism / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D009837:Oligodendroglioma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D010871:Pinealoma / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis
D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes