title: Improvement of HPMC tablet disintegration by the addition of inorganic salts.
abstract: Effects of inorganic salts on disintegration of hydroxypropylmethylcellulose (HPMC) matrix tablets have been studied. Adding disintegrants, such as Ac-di-sol, Primojel, Kolidon-CL, or low substituted hydroxypropylcellulose (L-HPC) to HPMC matrix tablets had no effect on disintegration property. Disintegration time was improved by adding NaHCO(3), KH(2)PO(4), K(2)SO(4), KCl, or NaCl to the HPMC tablets as tablet components. On the other hand, addition of Na(2)CO(3), or Na(2)SO(4) to the tablets showed no improvement of disintegration. The heat of dissolution of inorganic salts that improved disintegration of tablets was endothermic, while that of inorganic salts that did not improve disintegration of tablets was exothermic. These results suggested that the thermal environment and ionic strength inside the tablet might affect the disintegration of HPMC matrix tablets.
authors: Pharmaceutical Research and Technology Labs, Astellas Pharma Inc, Yaizu, Japan. atsushi.kajiyama@jp.astellas.com
authors: Atsushi
authors: A
authors: Kajiyama
authors: Hirokazu
authors: H
authors: Takagi
authors: Kunikazu
authors: K
authors: Moribe
authors: Keiji
authors: K
authors: Yamamoto
mesh_terms: D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013816:Thermodynamics
chemical_list: D005079:Excipients; D012492:Salts; D013607:Tablets; D065347:Hypromellose Derivatives; D008747:Methylcellulose