Loss of DNA damage checkpoint genes: switch from preferential induction of point mutations to chromosomal damage precedes the transition towards an aggressive cancer type.
Hengstler
J G
JG
Bolt
H M
HM
D000782:Aneuploidy; D002453:Cell Cycle / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D043171:Chromosomal Instability; D004249:DNA Damage / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D016296:Mutagenesis; D017354:Point Mutation / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology