title: Ruthenium-catalyzed one-pot carbenoid N-H insertion reactions and diastereoselective synthesis of prolines.
abstract: Aryl- and aliphatic-substituted 3-hydroxyprolines and various other amino esters are conveniently prepared by [RuCl2(p-cymene)]2-catalyzed one-pot intramolecular and intermolecular carbenoid N-H insertion reactions, respectively, and the prolines are formed with high diastereoselectivities. The catalytic reactions are tolerant toward air/moisture, and the product yields are insensitive to the organic solvents used.
authors: Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Feng Lin Road, Shanghai, China.
authors: Qing-Hai
authors: QH
authors: Deng
authors: Hai-Wei
authors: HW
authors: Xu
authors: Angella Wing-Hoi
authors: AW
authors: Yuen
authors: Zhen-Jiang
authors: ZJ
authors: Xu
authors: Chi-Ming
authors: CM
authors: Che
mesh_terms: D002384:Catalysis; D011392:Proline / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D012428:Ruthenium; D011392:Proline