Gadofullerene MRI contrast agents.
A promising new class of MRI contrast-enhancing agents with high relaxivities is based on gadolinium-containing metallofullerenes, which are also termed gadofullerenes. Detailed study of the water-proton relaxivity properties and intermolecular nanoclustering behavior of gadofullerene derivatives has revealed valuable information about their relaxivity mechanisms and given a deeper understanding of this new class of paramagnetic contrast agent. Here, the latest findings on water-solubilized gadofullerene materials and how these findings relate to their future applications in MRI are reviewed and discussed.
Bolskar
Robert D
RD
TDA Research, Inc., 12345 West 52nd Avenue, Wheat Ridge, CO 80033, USA. bolskar@tda.com.
D003287:Contrast Media; D004337:Drug Carriers / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000639:trends*; D050997:Nanomedicine / Q000639:trends*; D049329:Nanostructures / Q000737:chemistry
D003287:Contrast Media; D004337:Drug Carriers; D037741:Fullerenes; D005682:Gadolinium