title: [Effect of hypoxia on dedifferentiation of mature adipocytes: an experimental study].
abstract: OBJECTIVE
  To study the morphological changes of mature adipocytes in hypoxic condition in vitro and investigate the effect of hypoxia on dedifferentiation of mature adipocytes.
  
  
  METHODS
  Human adipose tissue was collected from individuals undergoing liposuction procedures, from which the stem cells were isolated and induced to become mature adipocytes. After cell culture in hypoxic condition, the adipocytes were observed for morphological changes at different time points.
  
  
  RESULTS
  After a few days of culture in hypoxic condition, the mature adipocytes derived from the adipose tissue-derived stem cells underwent morphological changes from spherical cells into fibroblast-like cells capable of continuous cell division.
  
  
  CONCLUSIONS
  Mature adipocytes may dedifferentiate into fibroblast-like cells under appropriate conditions.
authors: Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors: Yun-jun
authors: YJ
authors: Liao
authors: Jian-hua
authors: JH
authors: Gao
authors: Ping
authors: P
authors: Jiang
authors: Feng
authors: F
authors: Lu
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000273:Adipose Tissue / Q000166:cytology; D000293:Adolescent; D000328:Adult; D002454:Cell Differentiation / Q000502:physiology*; D015687:Cell Hypoxia; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D013234:Stem Cells / Q000166:cytology; D055815:Young Adult