title: Ascending and transverse aortic arch repair: the impact of glomerular filtration rate on mortality.
abstract: BACKGROUND
  Recent studies have described the importance of renal glomerular filtration rate (GFR) as a determinant of perioperative mortality in patients with aneurysms that involve the thoracoabdominal and abdominal aorta. We studied the impact of GFR on mortality following repair of ascending and arch aneurysms.
  
  
  METHODS
  Between February 1991 and August 2006, we performed 994 repairs of the ascending and transverse aortic arch. Nine hundred twenty patients had evaluable data for this study. Sixty-two percent were men (566/920); mean age was 65 years (range 17-89). We estimated the GFR using the Cockcroft-Gault equation. Mean preoperative serum creatinine was 1.2 +/- 0.9 mg/dl, mean GFR was 77 +/- 37 mL/min. Renal function data were arrayed in quartiles for univariate analysis and kept continuous for multivariable analyses. Multivariable analyses assessed demographics, extent of disease, acuity of presentation, and renal function measured by both creatinine and GFR.
  
  
  RESULTS
  Overall 30-day mortality was 10.8% (99/920). In univariate analyses, GFR (P < 0.0001), serum creatinine (P < 0.0003), coronary artery disease (P > 0.03), acute dissection (P < 0.03), emergency presentation (P < 0.002), age (P < 0.009), pump time (P < 0.0001), cross-clamp time, (P < 0.03) and circulatory arrest time (P < 0.003) were associated with increased mortality. By multivariable analyses, only GFR (P < 0.0001), pump time (P < 0.0001), emergency status (P < 0.002) were significant independent risk factors for mortality.
  
  
  CONCLUSIONS
  Preoperative renal function as defined by GFR was the most significant predictor of mortality during repairs of the ascending and transverse aortic arch. The use of GFR provides better preoperative risk stratification during these repairs than creatinine alone.
authors: Department of Cardiothoracic and Vascular Surgery, The University of Texas at Houston Medical School, Memorial Hermann Heart and Vascular Institute, Houston, TX 77030, USA. anthony.l.estrera@uth.tmc.edu
authors: Anthony L
authors: AL
authors: Estrera
authors: Charles C
authors: CC
authors: Miller
authors: Jaswanth
authors: J
authors: Madisetty
authors: Sebastian
authors: S
authors: Bourgeois
authors: Ali
authors: A
authors: Azizzadeh
authors: Martin A
authors: MA
authors: Villa
authors: Hazim J
authors: HJ
authors: Safi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000401:mortality; D001013:Aorta, Thoracic / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality* / Q000601:surgery*; D003327:Coronary Disease / Q000150:complications; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D003404:Creatinine