Impact of GnRH agonist treatment on recurrence of ovarian endometriomas after conservative laparoscopic surgery.
OBJECTIVE
To analyze the influence of postoperative GnRH agonist treatment on disease recurrence after conservative laparoscopic surgery for ovarian endometriomas according to duration of the treatment.


METHODS
Retrospective cohort study.


METHODS
University hospital.


METHODS
One hundred nine consecutive premenopausal women who underwent conservative laparoscopic surgery for ovarian endometriomas (endometriosis stage III/IV) were enrolled in the study. The patients were divided into four treatment groups: expectant management (n = 37) and GnRH agonist therapy for 3 (n = 28), 4 (n = 21), and 6 months (n = 23).


METHODS
None.


METHODS
An ultrasound confirmed recurrence of ovarian endometriomas.


RESULTS
The overall crude recurrence rate was 16.5% after follow-up for an average of 20.1 months. The crude recurrence and the cumulative probabilities of disease recurrence at 24/36 months tended to be lower in patients who received a GnRH agonist for 6 months (4.3%, 5.3%/5.3%) compared with those who received it for 3 months (17.9%, 12.5%/25.0%) and 4 months (28.6%, 18.9%/39.2%) and patients with expectant management (16.2%, 22.4%/37.9%). However, the differences did not reach statistical significance.


CONCLUSIONS
Treatment with GnRH agonist for six months had a beneficial impact on the recurrence rate after conservative laparoscopic surgery for ovarian endometriomas.
Jee
Byung Chul
BC
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Lee
Joong Yeup
JY
Suh
Chang Suk
CS
Kim
Seok Hyun
SH
Choi
Young Min
YM
Moon
Shin Yong
SY
D003131:Combined Modality Therapy; D004715:Endometriosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007723:Korea; D010535:Laparoscopy; D011336:Probability; D012008:Recurrence; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone