title: Comment on "Regularizing capacity of metabolic networks".
abstract: In a recent paper, Marr, Müller-Linow, and Hütt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of null models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr We argue that this issue calls for a more detailed type of modeling.
authors: Department of Computer Science, University of New Mexico, Albuquerque, NM 87131, USA.
authors: Petter
authors: P
authors: Holme
authors: Mikael
authors: M
authors: Huss