title: Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.
abstract: Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of CRA on the development of obesity and hepatic steatosis in KK-Ay mice, a genetically obese mouse model. Six-week-old KK-Ay mice were fed a high fat diet for 9 weeks with or without 0.023% CRA. Nine-week CRA treatment resulted in 10% lower body weight and 15% lower total fat (visceral plus subcutaneous fat) mass than in control mice. CRA treatment reduced fasting plasma levels of glucose, insulin, and triglyceride by 23%, 41%, and 22%, respectively. The improved insulin sensitivity in CRA-treated mice may be due on part to the increased plasma adiponectin and white adipose tissue (WAT) AdipoR1 levels. In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR) alpha in liver and PPAR gamma in WAT. This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPAR alpha in liver and PPAR gamma in WAT.
authors: Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.
authors: Kotaro
authors: K
authors: Yamada
authors: Masaya
authors: M
authors: Hosokawa
authors: Chizumi
authors: C
authors: Yamada
authors: Rie
authors: R
authors: Watanabe
authors: Shimpei
authors: S
authors: Fujimoto
authors: Hideya
authors: H
authors: Fujiwara
authors: Masaru
authors: M
authors: Kunitomo
authors: Toshihiro
authors: T
authors: Miura
authors: Tetsuo
authors: T
authors: Kaneko
authors: Kinsuke
authors: K
authors: Tsuda
authors: Yutaka
authors: Y
authors: Seino
authors: Nobuya
authors: N
authors: Inagaki
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis; D000273:Adipose Tissue / Q000473:pathology; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D004032:Diet; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D009765:Obesity / Q000188:drug therapy* / Q000473:pathology; D010084:Oxidation-Reduction; D047493:PPAR alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D054419:Receptors, Adiponectin / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014280:Triglycerides / Q000096:biosynthesis; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D052242:Adiponectin; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D047493:PPAR alpha; D054419:Receptors, Adiponectin; D014280:Triglycerides; D014315:Triterpenes; C475419:adiponectin receptor 1, mouse; C475421:adiponectin receptor 2, mouse; C113861:corosolic acid