title: Breast-conserving therapy for centrally located breast cancer.
abstract: OBJECTIVE
  To analyze whether breast-conserving therapy (BCT) may be an oncologically safe approach and result in a good cosmesis in patients with centrally located breast cancer (CLBC).
  
  
  BACKGROUND
  Only underpowered, retrospective, single-arm studies have suggested that oncoplastic BCT for CLBC may be oncologically safe and may result in a good cosmesis.
  
  
  METHODS
  The authors retrospectively analyzed the overall and recurrence-free survival in 1485 patients with breast cancer undergoing BCT comparing CLBC with non-CLBC. Moreover, the authors described 4 different oncoplastic techniques for BCT in patients with CLBC and compared the cosmetic results with simple lumpectomy according to a recently elaborated objective cosmetic evaluation system, the Breast Symmetry Index.
  
  
  RESULTS
  Kaplan-Meier curves show no significant difference in a 5-year overall, local, or distant recurrence-free survival between patients with CLBC and non-CLBC after BCT (94% vs. 96%; 100% vs. 98%; 92% vs. 90%; median follow-up, 35.3 months). The cosmetic outcome after oncoplastic BCT compared with simple lumpectomy differed significantly (Breast Symmetry Index: 22 +/- 6%d vs. 44 +/- 12%d; P < 0.05).
  
  
  CONCLUSIONS
  The results demonstrate that BCT for CLBC is oncologically safe and that oncoplastic techniques improve cosmesis.
authors: Department of Surgery, Medical University of Vienna, Austria. florian.fitzal@meduniwien.ac.at
authors: Florian
authors: F
authors: Fitzal
authors: Martina
authors: M
authors: Mittlboeck
authors: Herwig
authors: H
authors: Trischler
authors: Wilfried
authors: W
authors: Krois
authors: Greta
authors: G
authors: Nehrer
authors: Maria
authors: M
authors: Deutinger
authors: Raimund
authors: R
authors: Jakesz
authors: Michael
authors: M
authors: Gnant
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D004954:Esthetics; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome