title: Assessing health-related quality of life in patients with restless legs syndrome.
abstract: BACKGROUND
  Restless Legs Syndrome (RLS) has a substantial impact on normal daily activities. Because of the high prevalence it is necessary to evaluate the impact on the health-related quality of life (HRQoL).
  
  
  OBJECTIVE
  To assess health-related quality of life in patients with RLS.
  
  
  METHODS
  A total of 519 patients (327 female patients; mean age: 64.2 y) were recruited in five different German centers according to the diagnostic criteria of the International RLS Study Group. Patients were either interviewed or completed a mailed questionnaire. The questionnaire consisted of an evaluation of the sociodemographic, clinical and health-related status. HRQoL was evaluated with the EuroQoL (EQ-5D). In addition, the IRLS scale, the MOS Sleep Scale, the Epworth Sleepiness Scale, and the BDI were applied as clinical rating scales.
  
  
  RESULTS
  HRQoL is substantially affected by RLS. The mean EQ-5D-VAS was 55.6 and considerably lower compared to the general population. It was found to be as low as in other chronic neurological disorders such as Parkinson's disease and stroke. From different factors investigated by uni- and multivariate analyses, severity of RLS and depressive symptoms had the most significant impact on HRQoL. Additionally, sleep deficits, the duration of the disease and net household income were identified as predictors for different EQ-5D outcome scores.
  
  
  CONCLUSIONS
  RLS considerably affects HRQoL. Further comparative studies are necessary to evaluate the effect of disease symptoms on HRQoL and their change due to medication.
authors: Department of Clinical Neurophysiology, Klinikum Bremen-Ost, Bremen, Germany.
authors: Svenja
authors: S
authors: Happe
authors: Jens Peter
authors: JP
authors: Reese
authors: Karin
authors: K
authors: Stiasny-Kolster
authors: Ines
authors: I
authors: Peglau
authors: Geert
authors: G
authors: Mayer
authors: Jens
authors: J
authors: Klotsche
authors: Guido
authors: G
authors: Giani
authors: Max
authors: M
authors: Geraedts
authors: Claudia
authors: C
authors: Trenkwalder
authors: Richard
authors: R
authors: Dodel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003863:Depression / Q000523:psychology; D005260:Female; D005858:Germany; D006305:Health Status Indicators; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D012148:Restless Legs Syndrome / Q000503:physiopathology* / Q000523:psychology*; D012890:Sleep; D055815:Young Adult