Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diets.
The objective of this study was to investigate the effects of S&S PWH, a proprietary herb and fiber combination (Bionutrigen Inc., Daejon, Republic of Korea), on body weight and lipid metabolism in rats fed with a high-fat diet. Three groups of male Sprague-Dawley rats were fed different diets for a 6-week period: normal control diet containing 5% (wt/wt) corn oil (NC group), high-fat diet containing 10% (wt/wt) lard plus 5% (wt/wt) corn oil (HF group), and high-fat diet supplemented with powdered 5% (wt/wt) S&S PWH (S&S PWH group). The body weights and relative weights of the epididymal and perirenal white adipose tissue were significantly lower in the S&S PWH group than in the HF group. S&S PWH supplementation significantly lowered plasma total cholesterol and triglyceride concentrations, whereas it elevated the ratio of high density lipoprotein-cholesterol/total-cholesterol and improved the atherogenic index. The accumulation of hepatic lipid droplets and the epididymal white adipocyte size were less in the S&S PWH group than in the HF group. Hepatic hydroxyl-3-methylglutaryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase activities were significantly lower, while adipocyte lipoprotein lipase activity was significantly higher, in the S&S PWH group than in the HF group. These beneficial effects may be due to the combined properties of the phenolic compounds present in high concentrations (1.89 g/100 g) in the S&S PWH. In conclusion, these results suggest that S&S PWH can be considered as an anti-obesity functional formula that is effective for suppressing body weight gain and enhancing lipid profile.
Woo
Myoung-Nam
MN
Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
Bok
Song-Hae
SH
Lee
Mi-Kyung
MK
Kim
Hye-Jin
HJ
Jeon
Seon-Min
SM
Do
Gyeong-Min
GM
Shin
Su Kyung
SK
Ha
Tae Yeul
TY
Choi
Myung-Sook
MS
D017667:Adipocytes / Q000166:cytology; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage*; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000032:analysis; D004822:Epididymis; D022781:Hepatocytes / Q000166:cytology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008099:Liver / Q000737:chemistry; D008297:Male; D010636:Phenols / Q000032:analysis; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D019440:Anti-Obesity Agents; D008076:Cholesterol, HDL; D004041:Dietary Fats; D004043:Dietary Fiber; D000960:Hypolipidemic Agents; D010636:Phenols; D028321:Plant Preparations; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase; D008071:Lipoprotein Lipase