Pulmonary histoplasmosis.
Pulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment. The reader is referred to the earlier review for subjects not fully addressed herein. Knowledge of the utility of serological testing is essential, particularly when antigen tests and cultures are negative. Antigen testing is most useful in patients with more diffuse pulmonary involvement and those with progressive disseminated disease due to the high fungal burden. Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes.
Hage
Chadi A
CA
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Wheat
L Joseph
LJ
Loyd
James
J
Allen
Stephen D
SD
Blue
Deborah
D
Knox
Kenneth S
KS
D000935:Antifungal Agents / Q000627:therapeutic use; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D012698:Serologic Tests
D000935:Antifungal Agents