Bifunctional ligands based on the DOTA-monoamide cage.
Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.
Barge
Alessandro
A
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via Giuria, 9-10125, Torino, Italy.
Tei
Lorenzo
L
Upadhyaya
Dharita
D
Fedeli
Franco
F
Beltrami
Lorena
L
Stefanìa
Rachele
R
Aime
Silvio
S
Cravotto
Giancarlo
G
D000577:Amides / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure
D000577:Amides; D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D008024:Ligands; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid