title: Recurrent orbital inflammation and Whipple disease.
abstract: OBJECTIVE
  To describe a recurrent case of idiopathic orbital inflammation (OI) associated with Whipple disease.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 63-year-old woman developed myositis or idiopathic orbital inflammation (OI). Whipple disease had been diagnosed 1 year before by duodenal biopsy. OI appeared 1 year following the end of a long course of trimethoprim-sulfamethoxazole treatment. During follow-up months later, recurrent OI was noted in the same and contralateral orbits. Flare-ups of OI were suggestive of disease relapse and subsequent duodenal biopsy confirmed the presence of PAS-positive particles in macrophages. Treatment with trimethoprim-sulfamethoxazole and corticosteroids was necessary to prevent recurrences.
  
  
  CONCLUSIONS
  Recurrence of duodenal Whipple disease may be associated with an OI picture that is immmunologically mediated.
authors: Department of Ophthalmology, University Hospital Arnau de Vilanova, IRB-Lleida, Lleida, Spain. vhuerva@mixmail.com
authors: Valentín
authors: V
authors: Huerva
authors: Ramón
authors: R
authors: Espinet
authors: Carlos
authors: C
authors: Galindo
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004386:Duodenum; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D055502:Secondary Prevention; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000150:complications* / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination