The value of touch imprint cytology in EUS-guided Trucut biopsy.
BACKGROUND
EUS-guided Trucut biopsy (TCB) enables the acquisition of tissue cores for histologic assessment. Touch imprint cytology (TIC) can be performed at the time of a biopsy to assess the adequacy of the sample; however, limited information is available on the diagnostic value of TIC of these specimens.


OBJECTIVE
To investigate the diagnostic accuracy of TIC compared with a TCB.


METHODS
Consecutive EUS-guided TCB and TIC (n = 109) were retrospectively and independently reviewed by a surgical pathologist (for the TCB) and a cytopathologist (for TIC) blinded to the final diagnoses.


METHODS
University of Iowa Hospitals and Clinics, Iowa.


METHODS
Diagnostic accuracy of a TCB, TIC, and combined TCB + TIC.


RESULTS
The diagnostic accuracy of a TCB was 92.7% (95% CI, 83.1%-97.3%), TIC was 82.6% (95% CI, 74.3%-88.6%), and TCB + TIC was 95.4% (95% CI, of 89.4%-98.3%). The diagnostic accuracy of a TCB alone was superior to TIC alone (P = .038); a TCB was diagnostic in 14 cases that were nondiagnostic by TIC. The addition of TIC allowed for the identification of 3 malignancies (2.8%) that were not identified on TCB alone. In 22 cases, TIC was considered diagnostic, but a TCB provided additional specific diagnostic information.


CONCLUSIONS
Retrospective study and relatively low numbers.


CONCLUSIONS
TIC is a valuable tool for use in a EUS-guided TCB; TIC is independently diagnostically accurate, which allows for confidence in a rapid preliminary diagnosis, and it provides additional diagnostic value when combined with TCB.
Vanderheyden
Andrew D
AD
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
Proctor
Kerry A
KA
Rizk
Maged K
MK
Silva
Rogelio G
RG
Jensen
Chris S
CS
Gerke
Henning
H
D044963:Biopsy, Fine-Needle / Q000379:methods; D001707:Biopsy, Needle / Q000379:methods*; D016001:Confidence Intervals; D003584:Cytological Techniques; D019160:Endosonography; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology*; D011237:Predictive Value of Tests; D011336:Probability; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity