title: Novel bisbenzimidazoles with antileishmanial effectiveness.
abstract: A small library of 2,2'-[(alpha,omega-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC(50) values lower than that determined for pentamidine against L. donovani.
authors: Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans, LA 70125, USA.
authors: Annie
authors: A
authors: Mayence
authors: Aurélie
authors: A
authors: Pietka
authors: Margaret S
authors: MS
authors: Collins
authors: Melanie T
authors: MT
authors: Cushion
authors: Babu L
authors: BL
authors: Tekwani
authors: Tien L
authors: TL
authors: Huang
authors: Jean Jacques
authors: JJ
authors: Vanden Eynde
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006690:Bisbenzimidazole / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007893:Leishmania donovani / Q000187:drug effects; D015394:Molecular Structure; D045363:Pneumocystis carinii / Q000187:drug effects; D013329:Structure-Activity Relationship; D014346:Trypanosoma brucei brucei / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D006690:Bisbenzimidazole