title: Cryptogenic stroke in the setting of intravaginal prostaglandin therapy for elective abortion.
abstract: Vaginal prostaglandin pessaries are considered safe and effective method of abortion within the first two trimesters of pregnancy. We present a case of a young woman, with no known risk factors for cerebrovascular events, who developed a cryptogenic stroke following administration of intravaginal Misoprostol. Case report and review of the relevant literature. A 30-year-old woman presented with right hemiparesis and aphasia after having received three 600 microg tablets of intravaginal Misoprostol for an elective abortion earlier in the day. A brain MRI revealed an acute ischemic infarction in the left middle cerebral artery territory. An extensive workup for possible etiologies was negative. Intravaginal Misoprostol may be associated with stroke in young women. Further study is required to determine if this case represents an isolated incident, or a true association.
authors: Department of Neurology, University of Southern California, Los Angeles, CA 90033, United States.
authors: Nirali
authors: N
authors: Patel
authors: Ron
authors: R
authors: Shatzmiller
authors: Nerses
authors: N
authors: Sanossian
authors: Soma
authors: S
authors: Sahai-Srivastava
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000029:Abortion, Legal / Q000379:methods; D000282:Administration, Intravaginal; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000139:chemically induced* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects*; D010570:Pessaries; D011247:Pregnancy; D020521:Stroke / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol