An experimental model for fatal malaria due to TNF-alpha-dependent hepatic damage.
While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death.
Seixas
E
E
Instituto Gulbenkian de Ciência, Oeiras, Portugal. eseixas@igc.gulbenkian.pt
Oliveira
P
P
Moura Nunes
J F
JF
Coutinho
A
A
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D004195:Disease Models, Animal; D008099:Liver / Q000378:metabolism / Q000469:parasitology / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D008288:Malaria / Q000188:drug therapy / Q000401:mortality* / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D016788:Plasmodium chabaudi; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000906:Antibodies; D014409:Tumor Necrosis Factor-alpha