title: Association between GERD-related erosive esophagitis and obesity.
abstract: OBJECTIVE
  To date, many studies have reported on the association of obesity with gastroesophageal reflux disease (GERD), although none of these have been systematic. In light of this, we conducted this study to examine the association of obesity and GERD.
  
  
  METHODS
  A total of 3363 patients underwent gastroscopy at Hanyang University Health Promotion Center. Among these patients, we prospectively examined patients who were diagnosed with GERD-related erosive esophagitis on endoscopy.
  
  
  RESULTS
  Multivariate analysis showed that the significant risk factors were waist-to-hip ratio (WHR), hiatal hernia, body mass index (BMI), and smoking. As compared with patients who had a WHR less than 0.8, the multivariate odds ratio for erosive esophagitis were 4.055 for a WHR more than 1.0 and 2.316 for a WHR of 0.8 to 1.0. As compared with patients who had a BMI of 20 to 22.5, the multivariate odds ratio for erosive esophagitis was 3.308 (95% confidence interval, 1.792 to 6.107) for a BMI greater than 30.
  
  
  CONCLUSIONS
  Obesity, especially abdominal obesity, was the significant risk factor for erosive esophagitis.
authors: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. alwayshang@hanyang.ac.kr
authors: Hang Lak
authors: HL
authors: Lee
authors: Chang Soo
authors: CS
authors: Eun
authors: Oh Young
authors: OY
authors: Lee
authors: Yong Cheol
authors: YC
authors: Jeon
authors: Ju Hyun
authors: JH
authors: Sohn
authors: Dong Soo
authors: DS
authors: Han
authors: Byung Chul
authors: BC
authors: Yoon
authors: Ho Soon
authors: HS
authors: Choi
authors: Joon Soo
authors: JS
authors: Hahm
authors: Min Ho
authors: MH
authors: Lee
authors: Dong Hoo
authors: DH
authors: Lee
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D004941:Esophagitis / Q000453:epidemiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000503:physiopathology; D005773:Gastroscopy; D006551:Hernia, Hiatal / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D049629:Waist-Hip Ratio / Q000009:adverse effects