Peculiarities of norovirus and rotavirus infections in hospitalised young children.
OBJECTIVE
To investigate the features of norovirus infection in hospitalised children under the age of 3 and to compare the results with those of rotavirus infection.


METHODS
Case notes were randomly selected and retrospectively analysed for 70 norovirus- and 70 rotavirus-infected children. All of the children were treated in Vilnius University Children's Hospital in 2005. The norovirus antigen was assayed using enzyme-linked immunosorbent assay, the rotavirus using immunochromatography diagnostic assay.


RESULTS
In young children, norovirus infection manifested as vomiting (94% of all cases), diarrhoea (81%), and fever (66%). It presented as gastroenteritis with fever (47%) or without fever (30%). However, 19% of cases were without diarrhoea. During rotavirus infection, fever was present in 97% of cases and 81% of them were >38 degrees C. However, in norovirus infection, the percentages were 66% and 48%, respectively (P < 0.0001). Intensive diarrhoea (> or =7 times/day) more frequently appeared in children with rotavirus infection than with norovirus (P < 0.0001). Repeated vomiting (> or =4 times/day) has been more common for children with norovirus infection. As opposed to norovirus infection, which has 2 main syndromes (gastroenteritis with fever and without fever), rotavirus infection is dominated by just 1 clinical syndrome-gastroenteritis with fever (P < 0.0001).


CONCLUSIONS
Norovirus infection in young children can present as gastroenteritis with or without fever. Norovirus and rotavirus infections had statistically significant differences in the presence and the degree of fever, and the intensity of diarrhoea and vomiting, as well as frequency of different syndromes.
Narkeviciute
Irena
I
Clinic of Children's Diseases of Vilnius University, Vilnius, Lithuania. irena.narkeviciute@vuvl.lt
Tamusauskaite
Indre
I
D017250:Caliciviridae Infections / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000453:epidemiology / Q000821:virology; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000821:virology; D005759:Gastroenteritis / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D029322:Norovirus / Q000276:immunology / Q000302:isolation & purification; D012189:Retrospective Studies; D012401:Rotavirus / Q000276:immunology / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D012720:Severity of Illness Index; D014839:Vomiting / Q000453:epidemiology / Q000821:virology