title: Therapeutic cloning in individual parkinsonian mice.
abstract: Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.
authors: Department of Neurosurgery, Sloan-Kettering Institute, 1275 York Ave, New York, New York 10065, USA. tabarv@mskcc.org
authors: Viviane
authors: V
authors: Tabar
authors: Mark
authors: M
authors: Tomishima
authors: Georgia
authors: G
authors: Panagiotakos
authors: Sayaka
authors: S
authors: Wakayama
authors: Jayanthi
authors: J
authors: Menon
authors: Bill
authors: B
authors: Chan
authors: Eiji
authors: E
authors: Mizutani
authors: George
authors: G
authors: Al-Shamy
authors: Hiroshi
authors: H
authors: Ohta
authors: Teruhiko
authors: T
authors: Wakayama
authors: Lorenz
authors: L
authors: Studer
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002460:Cell Line; D019976:Cloning, Organism; D004298:Dopamine / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000637:transplantation*; D051379:Mice; D020297:Mice, Congenic; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism / Q000637:transplantation; D053652:Nuclear Transfer Techniques; D020734:Parkinsonian Disorders / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D004298:Dopamine