title: Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis.
abstract: OBJECTIVE
  We investigated the prevalence and relationship of peptic ulcer disease and Helicobacter pylori infection to liver cirrhosis.
  
  
  METHODS
  We examined 288 patients with liver cirrhosis, 322 patients with non-ulcer dyspepsia, and 339 patients with peptic ulcer disease. Rapid urease test and Wright-Giemsa staining were used for diagnosis of H. pylori infection.
  
  
  RESULTS
  The prevalence of peptic ulcer disease in patients with cirrhosis was 24.3%. The prevalence of peptic ulcer disease in patients with cirrhosis divided into Child-Pugh classes A, B, and C was 22.3%, 21.0%, and 31.3%, respectively (p > 0.05). The prevalence of H. pylori infection in the patients with cirrhosis, non-ulcer dyspepsia, and peptic ulcer without chronic liver disease were 35.1%, 62.4%, and 73.7%, respectively (p < 0.001). The prevalence of H. pylori infection did not differ depending on whether there was peptic ulcer (35.6%) or not (34.9%) in patients with liver cirrhosis (p > 0.05). The prevalence of H. pylori infection in patients with hepatitis virus-related liver cirrhosis and in the patients with alcohol-related liver cirrhosis was 42.5% and 22.0%, respectively (p < 0.001). The prevalence of H. pylori infection in patients with Child-Pugh classes A, B, and C liver cirrhosis was 51.5%, 30.5%, and 20.0%, respectively (p < 0.001).
  
  
  CONCLUSIONS
  Factors other than H. pylori may be involved in the pathogenesis of peptic ulcer disease in the setting of liver cirrhosis.
authors: Department of Internal Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea. djkim@hallym.ac.kr
authors: Dong Joon
authors: DJ
authors: Kim
authors: Hak Yang
authors: HY
authors: Kim
authors: Sung Jung
authors: SJ
authors: Kim
authors: Tae Ho
authors: TH
authors: Hahn
authors: Myoung Kuk
authors: MK
authors: Jang
authors: Gwang Ho
authors: GH
authors: Baik
authors: Jin Bong
authors: JB
authors: Kim
authors: Sang Hoon
authors: SH
authors: Park
authors: Myung-Seok
authors: MS
authors: Lee
authors: Choong Kee
authors: CK
authors: Park
mesh_terms: D000328:Adult; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000150:complications* / Q000453:epidemiology*