Travoprost/timolol fixed combination.
BACKGROUND
Travoprost and timolol are topical ocular hypotensive medications that have been used in the treatment of glaucoma. The fixed combination eye drop, Duotrav (travoprost 0.004% and timolol maleate 0.5%), has recently been introduced into the market.


OBJECTIVE
In this paper, the results of clinical trials and existing data on the performance of travoprost/timolol are discussed and analyzed.


METHODS
Appopriate studies for review were identified using PubMed. Studies selected for review compared efficacy and side-effect profile of fixed combination travoprost/timolol with travoprost and timolol used concomitantly, latanoprost and timolol used concomitantly, fixed combination latanoprost/timolol, travoprost alone and timolol alone.


CONCLUSIONS
Fixed combination eye drops such as travoprost/timolol offer the potential benefits of increased patient adherence, reduced exposure to preservatives, and reduced cost.
Herceg
Michael
M
University of Pittsburgh School of Medicine, UPMC Eye Center, 203 Lothrop Street, Suite 820, Pittsburgh, PA 15213, USA.
Noecker
Robert
R
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004338:Drug Combinations; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D009798:Ocular Hypertension / Q000188:drug therapy*; D010349:Patient Compliance; D013999:Timolol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000069557:Travoprost
D000959:Antihypertensive Agents; D004338:Drug Combinations; D003008:Cloprostenol; D013999:Timolol; D000069557:Travoprost