title: Regional heterogeneity of air trapping at expiratory thin-section CT of patients with bronchiolitis: potential implications for dose reduction and CT protocol planning.
abstract: OBJECTIVE
  To prospectively determine whether the regional distribution of air trapping in patients with suspected or overt bronchiolitis is heterogeneous, and to determine the effect that a simulated reduction of computed tomographic (CT) sections and of scanned anatomic regions would have on the assessment of the extent of air trapping.
  
  
  METHODS
  For this Ethical Committee-approved study, multi-detector row CT (collimation, 4 x 1 mm; rotation time, 0.5 second; 140 kVp; and 80 effective mAs) was performed in 47 lung transplant recipients (23 women, 24 men; mean age, 41 years +/- 12 [standard deviation]; 18 without bronchiolitis, 18 with potential bronchiolitis, and 11 with bronchiolitis, as determined by lung function measurements). Images were reconstructed with a thickness of 1 mm at an increment of 10 mm. The extent of air trapping in the upper, middle, and lower lung regions was correlated. Differences between regions and the interaction between patients and regions were tested with an analysis of variance. The extent of air trapping was calculated for six simulated examination protocols.
  
  
  RESULTS
  Correlations between the upper and middle (r = 0.930), the upper and lower (r = 0.756), and the middle and lower lung regions (r = 0.863) were significant (P < .001). The extent of air trapping increased from the upper to the lower lung region, with significant differences between regions (P < .001). There was a significant interaction between patients and lung regions (P < .001). Simulated examination protocols resulted in significantly different extents of air trapping (P < .001).
  
  
  CONCLUSIONS
  The regional distribution of the extent of air trapping in suspected or overt bronchiolitis is heterogeneous. Because the extent of air trapping can depend on the examination protocol, identical protocols are needed when air trapping is being compared within and between patients.
authors: Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA. abankier@bidmc.harvard.edu
authors: Alexander A
authors: AA
authors: Bankier
authors: Sheida
authors: S
authors: Mehrain
authors: Daniela
authors: D
authors: Kienzl
authors: Michael
authors: M
authors: Weber
authors: Marc
authors: M
authors: Estenne
authors: Pierre Alain
authors: PA
authors: Gevenois
mesh_terms: D000328:Adult; D000388:Air; D000704:Analysis of Variance; D016477:Artifacts; D001988:Bronchiolitis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed / Q000379:methods*