title: Assessment of fluid-responsiveness parameters for off-pump coronary artery bypass surgery: a comparison among LiDCO, transesophageal echochardiography, and pulmonary artery catheter.
abstract: OBJECTIVE
  To verify the reliability of different markers of fluid-responsiveness during off-pump cardiac surgery (OPCAB).
  
  
  METHODS
  A clinical prospective, nonblinded, nonrandomized study.
  
  
  METHODS
  A community hospital.
  
  
  METHODS
  Nineteen patients.
  
  
  METHODS
  Pulmonary artery catheter (PAC), LiDCO (LiDCO, London, UK), and transesophageal echocardiography (TEE) parameters were measured before (t0) and after (t1) a fluid challenge was performed 20 minutes after induction of anesthesia, but before sternotomy and without inotropic infusion. A Student t test and Spearman test were performed for statistical analysis.
  
  
  RESULTS
  According to the variation of cardiac index after the fluid challenge (DeltaCI%), 2 groups of patients were identified: the responders (Re, DeltaCI% > 15%) and the nonresponders (nRe). Mean pulse pressure variation (PPV) and mean stroke volume variation (SVV) before the fluid challenge (t0) were significantly different between the 2 groups. No significant differences were shown in systolic pressure variation (SPV), left ventricular end-diastolic area, left ventricular end-diastolic volume, and peak changes of aortic flow (DeltaVAo). A statistically significant correlation was observed between DeltaCI% and PPV (R = 0.793), DeltaCI% and SVV (R = 0.809), and DeltaCI% and SPV (R = 0.766). No correlation with central venous pressure and pulmonary capillary wedge pressure was found.
  
  
  CONCLUSIONS
  Dynamic parameters of fluid responsiveness by LiDCO are highly sensitive for assessment of intravascular volume status during OPCAB surgery. In contrast, even if static parameters by TEE reflect changes in ventricular diastolic volume, they are poor indicators of fluid responsiveness. Surprisingly, no significant correlation between DeltaVAo (TEE) and DeltaCI% was found.
authors: Department of Cardiac Anaesthesia and ICU, Sant'Anna e San Sebastiano Hospital, Caserta, Italy.
authors: Luigi
authors: L
authors: Belloni
authors: Antonio
authors: A
authors: Pisano
authors: Armando
authors: A
authors: Natale
authors: Maria Rosario
authors: MR
authors: Piccirillo
authors: Luigi
authors: L
authors: Piazza
authors: Gennaro
authors: G
authors: Ismeno
authors: Giovanni
authors: G
authors: De Martino
mesh_terms: D000368:Aged; D001810:Blood Volume / Q000502:physiology*; D002407:Catheterization, Swan-Ganz / Q000379:methods*; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D017548:Echocardiography, Transesophageal / Q000379:methods*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000502:physiology