title: Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.
abstract: Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.
authors: Department of Psychopharmacology, H. Lundbeck A/S, Ottiliavej 9, Valby, Denmark. bbs@lundbeck.com
authors: Brian Villumsen
authors: BV
authors: Broberg
authors: Rebecca
authors: R
authors: Dias
authors: Birte Yding
authors: BY
authors: Glenthøj
authors: Christina Kurre
authors: CK
authors: Olsen
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001288:Attention / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D005260:Female; D008297:Male; D009812:Odorants; D010622:Phencyclidine; D011247:Pregnancy; D051381:Rats; D012559:Schizophrenia / Q000139:chemically induced* / Q000503:physiopathology*; D012737:Sex Factors
chemical_list: D010622:Phencyclidine