Microbial metabolism of 1-aminoanthracene by Beauveria bassiana.
The carcinogen and mutagen, 1-aminoanthracene, was efficiently metabolized by the fungal strain Beauveria bassiana ATCC 7159 to yield three new metabolites identified as 1-acetamido-5-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthracene, 1-acetamido-8-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthraquinone, and 1-acetamido-6-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthraquinone, together with 1-acetamidoanthracene and 1-acetamidoanthraquinone. Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation.
Zhan
Jixun
J
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706-6800, USA.
Gunatilaka
A A Leslie
AA
D000107:Acetylation; D000873:Anthracenes / Q000737:chemistry / Q000378:metabolism*; D000880:Anthraquinones / Q000737:chemistry / Q000378:metabolism; D052982:Beauveria / Q000378:metabolism*; D002273:Carcinogens / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006900:Hydroxylation; D015394:Molecular Structure; D009153:Mutagens / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000873:Anthracenes; D000880:Anthraquinones; D002273:Carcinogens; D009153:Mutagens; C049062:1-aminoanthracene