title: Efficient, selective, and green: catalyst tuning for highly enantioselective reactions of ethylene.
abstract: Fine tuning of the biaryl and amino moieties of Feringa's phosphoramidite ligands yields structurally simpler, yet more efficient and selective, ligands for asymmetric hydrovinylation of vinylarenes and acylic 1,3-dienes. The enantioselectivities and yields observed in the formation of the 3-arylbutenes are among the highest for all asymmetric catalytic processes reported to date for the synthesis of intermediates for the widely used antiinflammatory 2-arylpropionic acids including naproxen, ibuprofen, fenoprofen, and flurbiprofen.
authors: Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA.
authors: Craig R
authors: CR
authors: Smith
authors: T V
authors: TV
authors: RajanBabu
mesh_terms: D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005030:Ethylenes; C036216:ethylene