Synthesis of 1-aminoimidazo[5,1-a]isoquinolinium salts based on multicomponent reactions of isocyanides.
A novel pseudo-four-component condensation yielding 1-aminoimidazo[5,1- a]isoquinolinium salts from isocyanides, isoquinoline, and sulfonic or bromic acids is described. The method offers several advantages including high yields of products and an easy experimental workup procedure.
Shaabani
Ahmad
A
Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
Soleimani
Ebrahim
E
Khavasi
Hamid Reza
HR
D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008958:Models, Molecular; D015394:Molecular Structure; D011806:Quinolinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012015:Reference Standards; D012492:Salts / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
C529952:1-aminoimidazo(5,1-a)isoquinolinium; D003486:Cyanides; D007093:Imidazoles; D007546:Isoquinolines; D011806:Quinolinium Compounds; D012492:Salts; C039109:isoquinoline