Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus.
In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), and ellagic acid (4). Their structures were elucidated by spectroscopic analyses. Among them, davallialactone (7), hypholomine B (9), and ellagic acid (4) exhibited potent rat lens aldose reductase and human recombinant aldose reductase inhibitory activity with IC50 values of 0.33, 0.82, 0.63 microM and 0.56, 1.28, 1.37 microM, respectively.
Lee
Yeon Sil
YS
Department of Food Science and Nutrition, Hallym University, Chuncheon 200-702, Korea.
Kang
Young-Hee
YH
Jung
Ju-Young
JY
Kang
Il-Jun
IJ
Han
Sang-No
SN
Chung
Jong-Sang
JS
Shin
Hyun-Kyung
HK
Lim
Soon Sung
SS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D005612:Freeze Drying; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D007202:Indicators and Reagents; D007908:Lens, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000737:chemistry
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D011994:Recombinant Proteins; D000449:Aldehyde Reductase