title: Optical coherence tomography evaluation of posterior capsule opacification related to intraocular lens design.
abstract: OBJECTIVE
  To evaluate posterior capsule opacification (PCO) and the impact of different intraocular lens (IOL) models on PCO characteristics using optical coherence tomography (OCT).
  
  
  METHODS
  Eighty-three eyes with PCO (fibrosis or pearl type) and 32 pseudophakic eyes without PCO were included. Horizontal 3.0 mm long OCT scans of the posterior capsule were obtained. Measurements and means of the peak posterior capsule intensity (PCI) and posterior capsule thickness (PCT) (distance between 2 spikes at posterior capsule) at 3 scan points were recorded. The PCI and PCT were compared with best corrected visual acuity (BCVA) and IOL data.
  
  
  RESULTS
  The PCT was high for IOLs with a rounded edge (P = .001) and with poly(methyl methacrylate) (PMMA) IOLs (P<.001). If the IOL optic was concave-convex, the PCT was higher than if the optic was biconvex (P = .001). The PCT of hydrophilic acrylic IOLs was higher than of hydrophobic acrylic IOLs (P = .04). Multivariate analysis of PCT showed that PMMA was the only factor statistically associated with PCT (P = .02). The worse logMAR BCVA correlated significantly with a higher PCT value (P<.001) but not with PCI (P = .42). An IOL size of 12.5 mm was related to fibrosis-type PCO (odds ratio, 3.14; P = .04).
  
  
  CONCLUSIONS
  The PCT was most affected by IOL characteristics. Poly(methyl methacrylate) IOLs and IOLs with rounded edges were associated with higher PCT. Hydrophilic acrylic IOLs were associated with greater PCT than hydrophobic IOLs. Posterior capsule thickness was a factor in decreased BCVA.
authors: Department of Ophthalmology, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
authors: Javier
authors: J
authors: Moreno-Montañés
authors: Aurora
authors: A
authors: Alvarez
authors: Maira
authors: M
authors: Bes-Rastrollo
authors: Alfredo
authors: A
authors: García-Layana
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D002386:Cataract / Q000175:diagnosis*; D005355:Fibrosis / Q000175:diagnosis; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D019904:Polymethyl Methacrylate; D011183:Postoperative Complications; D011474:Prosthesis Design; D019591:Pseudophakia / Q000175:diagnosis; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
chemical_list: D000180:Acrylic Resins; D019904:Polymethyl Methacrylate