title: [P-glycoprotein and human immunodeficiency virus infection].
abstract: P-glycoprotein (PGP) is a membrane protein and product of the MDR-1 gene, which acts as an efflux pump for several drugs, such as protease inhibitors (PI) used in HIV. Numerous studies in vitro, in experimental animals, and in patients have analyzed the relationships between PGP and the pharmacokinetic and pharmacodynamic properties of antiretroviral agents, with differing conclusions. In addition, studies focusing on the impact of single nucleotide polymorphisms in the MDR-1 gene, mainly C3435T in exon 26 and G2677A/G2677T in exon 21, on antiretroviral plasma concentrations, efficacy and adverse effects, have reported varying results, which have been attributed to the influence of other polymorphisms, such as cytochrome P450.
authors: Servicio de Medicina Interna, Hospital Sierrallana, Torrelavega, Cantabria, Spain. gpf@mundivia.es
authors: Galo
authors: G
authors: Peralta
authors: María Blanca
authors: MB
authors: Sánchez
authors: Santiago
authors: S
authors: Echevarría
authors: Elsa María
authors: EM
authors: Valdizán
authors: Juan Antonio
authors: JA
authors: Armijo
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects* / Q000502:physiology*; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D044966:Anti-Retroviral Agents