Coaxially electrospun micro/nanofibrous poly(epsilon-caprolactone)/eggshell-protein scaffold.
Eggshell membrane (ESM) has potential as a natural scaffold because of its highly porous structure and good biocompatibility. To mimic its structure and surface properties, soluble eggshell membrane protein (SEP) was extracted from ESM and electrospun with a biodegradable polymer, poly(epsilon-caprolactone) (PCL). SEP/PCL micro/nanofibers were fabricated using a coaxial electrospinning process with a dual nozzle and an auxiliary cylindrical electrode. The fiber web was characterized using the water contact angle, pore-size distribution, mechanical properties and cellular behavior. The SEP/PCL web, which demonstrated the feasibility of producing a scaffold with adequate hydrophilicity, suitable pore size and good mechanical properties compared to a pure PCL micro/nanofiber web, exhibits the ability to mimic a natural biomaterial.
Kim
Geun Hyung
GH
Nature-Inspired Bio-Mechanical Team, Division of Nano-Machinery, Korea Institute of Machinery and Materials, 171 Jang-dong, Yuseong-gu, Daejeon 305-343, South Korea. gkim@kimm.re.kr
Min
Taijin
T
Park
Su A
SA
Kim
Wan Doo
WD
D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D002645:Chickens; D003460:Crystallization / Q000379:methods*; D004527:Egg Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D004548:Elasticity; D004563:Electrochemistry / Q000379:methods; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D012399:Rotation; D013314:Stress, Mechanical
D004527:Egg Proteins; D011091:Polyesters; C015753:chorion proteins; C016240:polycaprolactone