title: Ixabepilone, a novel epothilone analog in the treatment of breast cancer.
abstract: BACKGROUND
  Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing cell death. Ixabepilone (BMS-247550, Ixempra) is an epothilone analog that optimizes the properties naturally observed with epothilone B.
  
  
  OBJECTIVE
  To provide an overview of the results achieved by ixabepilone in metastatic breast cancer.
  
  
  METHODS
  A PubMed search was performed to provide an extensive review of all published data on ixabepilone, in addition to all data reported from international congresses, from 2003 to 2007.
  
  
  CONCLUSIONS
  There is a clear need for new agents active against resistant metastatic breast cancer and ixabepilone might be a welcome new compound in this situation.
authors: Oncologie Médicale, CHU J Minjoz, 25000 Besançon, France. xavier.pivot@univ-fcomte.fr
authors: Xavier
authors: X
authors: Pivot
authors: Christian
authors: C
authors: Villanueva
authors: Loïc
authors: L
authors: Chaigneau
authors: Thierry
authors: T
authors: Nguyen
authors: Martin
authors: M
authors: Demarchi
authors: Tristan
authors: T
authors: Maurina
authors: Ulrich
authors: U
authors: Stein
authors: Christophe
authors: C
authors: Borg
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D004353:Drug Evaluation, Preclinical; D034261:Epothilones / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D009362:Neoplasm Metastasis; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; D050257:Tubulin Modulators; C430592:ixabepilone