[Biology of thioredoxin and its association with Alzheimer's disease and Parkinson's disease].
Thioredoxin (Trx) is a crucial protein for antioxidative defense, as well as a redox regulator of the intra- and extracellular signaling pathways and transcription factors. In this review, we focus on mammalian Trx and its association with Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the evidence of neuroprotective effects of Trx, up-regulation of Trx may be a good strategy for prevention and treatment of AD and PD.
Li
Li-Bo
LB
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Liu
Geng-Tao
GT
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000502:physiology; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism*; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000378:metabolism*; D013879:Thioredoxins / Q000378:metabolism* / Q000502:physiology
D000975:Antioxidants; D018696:Neuroprotective Agents; D013879:Thioredoxins