Coffee, tea, colas, and risk of epithelial ovarian cancer.
Associations of coffee, tea, and other caffeinated beverages with ovarian cancer risk remain uncertain. In a population-based study in Washington State, 781 women with epithelial ovarian cancer diagnosed in 2002 to 2005 and 1,263 controls completed self-administered questionnaires detailing consumption of caffeinated and noncaffeinated coffee, teas, and colas and in-person interviews regarding reproductive and hormonal exposures. We assessed risk associated with coffee, tea, and cola drinking and with total caffeine consumption using logistic regression to calculate odds ratios and 95% confidence intervals. Neither caffeinated nor decaffeinated coffees were associated with ovarian cancer risk; also, we observed no association of total caffeine with risk using a combined index that summed intake from coffee, tea, and carbonated soft drinks. Among teas, neither herbal/decaffeinated nor black teas were associated with risk; however, women who reported drinking >or=1 cup/d of green tea had a 54% reduction in risk (P trend = 0.01). Associations of green tea with risk were similar when invasive and borderline cases were considered separately and when Asian women were excluded from analysis. Green tea, which is commonly consumed in countries with low ovarian cancer incidence, should be further investigated for its cancer prevention properties.
Song
Yoon Ju
YJ
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 99109-1024, USA.
Kristal
Alan R
AR
Wicklund
Kristine G
KG
Cushing-Haugen
Kara L
KL
Rossing
Mary Anne
MA
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003069:Coffee; D030221:Cola; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013662:Tea; D014861:Washington / Q000453:epidemiology
D003069:Coffee; D013662:Tea