How do mesenchymal stromal cells suppress T cells?
Accumulating information indicates that mesenchymal stem or stromal cells (MSCs) are immunomodulatory, but the data to explain the observations are frequently conflicting. In this issue of Cell Stem Cell, Ren et al. (2008) provide evidence for a possible underlying mechanism of MSC-mediated T cell suppression. A perspective for considering these interesting observations is discussed.
Keating
Armand
A
Princess Margaret Hospital, 610 University Avenue, Suite 5-303, Toronto, ON M5G 2M9, Canada. armand.keating@uhn.on.ca
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D018925:Chemokines / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000276:immunology* / Q000378:metabolism; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology; D013491:Suppressor Factors, Immunologic / Q000378:metabolism / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D018925:Chemokines; D013491:Suppressor Factors, Immunologic; D009569:Nitric Oxide