Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration.
OBJECTIVE
To evaluate the hepatic effect of Croton cajucara Benth (sacaca) herbal extract in rats.


METHODS
60 Wistar rats (Rattus novergicus albinus) were used, weighing between 250 and 350 g. The animals were distributed randomically in 2 groups: GS - animals which received daily 0,1 ml/ 100 g of sacaca herbal extract through gavage, and GA -animals which received daily 0,1 ml/100g of distilled water through gavage. These were distributed in 3 subgroups with 10 animals, according to theirs euthanasia dates, which were 14th, 28th and 56th day of treatment.


RESULTS
Architectural alterations were not observed, however when it was analyzed the presence or absence of necrosis, it was observed in 50% of GS28 subgroup and 90% of subgroup. In 50% of the animals from GS28 subgroup and 90% of GS56 subgroup was observed vast degeneration areas and zonal necrosis, regarding center-lobular veins alterations, there were no alterations in any of the groups


CONCLUSIONS
The Croton cajucara Benth (sacaca) herbal extract in this experiment caused degeneration and hepatic necrosis, suggesting dose-dependent action.
Graim
Jair Francisco de Santana
JF
Integrated Health Department, State University of Pará, Brazil. Jgraim@yahoo.com.br
Lopes Filho
Gaspar de Jesus
Gde J
Brito
Marcus Vinicius Henriques
MV
Brasil Matos
Lia Tavares de Moura
LT
D000818:Animals; D029802:Croton / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D010936:Plant Extracts / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010936:Plant Extracts