title: Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.
abstract: Non-invasive laser-induced photoacoustic tomography (PAT) is an emerging imaging modality that has the potential to image the dynamic function of the brain due to its unique ability of imaging biological tissues with high optical contrast and ultrasound resolution. Here we report the first application of our finite-element-based PAT for imaging of epileptic seizures in an animal model. In vivo photoacoustic images were obtained in rats with focal seizures induced by microinjection of bicuculline, a GABA(A) antagonist, into the neocortex. The seizure focus was accurately localized by PAT as confirmed with gold-standard electroencephalogram (EEG). Compared to the existing neuroimaging modalities, PAT not only has the unprecedented advantage of high spatial and temporal resolution in a single imaging modality, but also is portable and low in cost, making it possible to bring brain imaging to the bedside.
authors: The J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
authors: Qizhi
authors: Q
authors: Zhang
authors: Zhao
authors: Z
authors: Liu
authors: Paul R
authors: PR
authors: Carney
authors: Zhen
authors: Z
authors: Yuan
authors: Huanxin
authors: H
authors: Chen
authors: Steven N
authors: SN
authors: Roper
authors: Huabei
authors: H
authors: Jiang
mesh_terms: D000162:Acoustics; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D003292:Convulsants / Q000494:pharmacology; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*; D014463:Ultrasonography / Q000379:methods
chemical_list: D003292:Convulsants; D001640:Bicuculline