title: [Significance of determination of gamma-interferon in the diagnosis of tuberculous exudative pleurisy].
abstract: The pleural fluid concentration of gamma-interferon (gamma-IFN) was studied in 44 patients with exudative pleurisy. The tuberculous nature of exudative pleurisy was established in 25 patients on the basis of X-ray study, a follow-up, microbiological study of pleural exudate specimens, and morphological studies of biopsy specimens obtained at video-assisted thoracoscopy or surgery. The the pleural exudate concentrations of gamma-IFN were over 300 pg/ml (mean 1019 +/- 161 pg/ml) in 19 out of 21 patients with exudative pleuritis in a phase of active inflammation. The patients with the fibrous outcome of pleurisy of tuberculous etiology and those with exudative pleurisy of non-tuberculous etiology, including that in malignancies and papapneumonic pleurisy, were observed to have lower concentrations of gamma-IFN (mean 118 +/- 16 pg/ml). With the discriminating level of above 300 pg/ml, the sensitivity and specificity of the test were 90.5 and 100%, respectively.
authors: S D
authors: SD
authors: Darenskaia
authors: N V
authors: NV
authors: Makarova
authors: M A
authors: MA
authors: Vladimirskiĭ
authors: S E
authors: SE
authors: Borisov
authors: M N
authors: MN
authors: Emel'ianov
authors: K I
authors: KI
authors: Kol'tsov
authors: E E
authors: EE
authors: Efremov
authors: G V
authors: GV
authors: Ignashenkova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D012720:Severity of Illness Index; D014396:Tuberculosis, Pleural / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*
chemical_list: D007371:Interferon-gamma