Novel carboranyl derivatives of nucleoside mono- and diphosphites and phosphonates: a synthetic investigation.
A number of nucleoside mono- and diphosphites and phosphonates containing 1,2-dicarbadodecaborane (12) (la-6b) at 5'-position of the sugar moiety have been synthesized in good yields. Experimental details along with the spectroscopic and analytical data, supporting the formation of the title compounds, are presented. These constitute a new generation of boron compounds that are envisioned to be useful in cancer treatment via Boron Neutron Capture Therapy (BNCT).
Vyakaranam
Kamesh
K
Department of Chemistry and Biochemistry, Michael Faraday Laboratories, Northern Illinois University, DeKalb, Illinois 60115-2862, USA.
Hosmane
Narayan S
NS