title: Stratified and randomized play-the-winner rule.
abstract: In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.
authors: Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors: Yuanyuan
authors: Y
authors: Liang
authors: Kimmie Chough
authors: KC
authors: Carriere
mesh_terms: D001699:Biometry / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D011897:Random Allocation; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*