Cell secretion: an update.
This past decade has witnessed the publication of a flurry of scientific papers and reports on the subject of cell secretion, following discovery of a permanent plasma membrane structure termed 'porosome' and its determination as the universal secretory machinery in cells. This discovery has led to a paradigm shift in our understanding of the secretory process, demonstrating that membrane-bound secretory vesicles transiently dock and fuse at the porosome base to release their contents to the cell exterior. The regulated release of intravesicular contents during cell secretion is governed by dilation of the porosome opening to the outside, and the extent of vesicle swelling. In agreement, a great number of articles have been written and studies performed, which are briefly discussed in this article.
Jeremic
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Department of Biological Sciences, George Washington University, Washington, DC 20052, USA. jerema@gwu.edu
D000818:Animals; D021961:Cell Membrane Structures / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D046790:Pancreas, Exocrine / Q000166:cytology; D050600:SNARE Proteins / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism* / Q000648:ultrastructure
D050600:SNARE Proteins