title: Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events.
abstract: BACKGROUND
  We aimed to evaluate the additional information of 18 fluorodeoxyglucose (FDG) arterial uptake with respect to other conventional cardiovascular risk factors and arterial calcifications in patients with stable cancer.
  
  
  RESULTS
  We compared the rate of cardiovascular events in 2 groups of patients with (n = 45) and without (n = 56) enhanced arterial 18FDG uptake, matched for the main clinical parameters. The extent and intensity of 18FDG uptake were quantified. A calcification index was also determined. About one third of the selected patients had a history of cardiovascular events and thus could be defined as "vulnerable patients." Old cardiovascular events (>6 months before or after positron emission tomography [PET]) and recent cardiovascular events (<6 months before or after PET) were significantly more frequent in the high-FDG uptake group than in the low-FDG uptake group (48% vs 15%, respectively [P = .0006], and 30% vs 1.8%, respectively [P = .0002]). The extent of 18FDG arterial uptake was the unique factor significantly related to the occurrence of a recent event by either logistic regression or discriminant analysis (P = .004 for all). Conversely, calcium index was the single factor related to old events (P = .004 and P = .002, respectively).
  
  
  CONCLUSIONS
  Extensive arterial 18FDG uptake might be an indicator of an evolving atherosclerotic process and should be mentioned in PET/computed tomography reports.
authors: Department of Nuclear Medicine, Hôpital Européen Georges Pompidou (Assistance Publique-Hôpitaux de Paris), Paris, France. benoit.paulmier@egp.aphp.fr
authors: Benoît
authors: B
authors: Paulmier
authors: Michèle
authors: M
authors: Duet
authors: Raphaël
authors: R
authors: Khayat
authors: Nadia
authors: N
authors: Pierquet-Ghazzar
authors: Jean-Pierre
authors: JP
authors: Laissy
authors: Christophe
authors: C
authors: Maunoury
authors: Florent
authors: F
authors: Hugonnet
authors: Elisabeth
authors: E
authors: Sauvaget
authors: Ludovic
authors: L
authors: Trinquart
authors: Marc
authors: M
authors: Faraggi
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging / Q000378:metabolism; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18