title: Daptomycin exerts bactericidal activity without lysis of Staphylococcus aureus.
abstract: The ability of daptomycin to produce bactericidal activity against Staphylococcus aureus while causing negligible cell lysis has been demonstrated using electron microscopy and the membrane integrity probes calcein and ToPro3. The formation of aberrant septa on the cell wall, suggestive of impairment of the cell division machinery, was also observed.
authors: Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, MA 02421, USA.
authors: Nicole
authors: N
authors: Cotroneo
authors: Robert
authors: R
authors: Harris
authors: Nancy
authors: N
authors: Perlmutter
authors: Terry
authors: T
authors: Beveridge
authors: Jared A
authors: JA
authors: Silverman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001433:Bacteriolysis / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D017576:Daptomycin / Q000494:pharmacology*; D005452:Fluoresceins; D005456:Fluorescent Dyes; D046529:Microscopy, Electron, Transmission; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D005452:Fluoresceins; D005456:Fluorescent Dyes; D017576:Daptomycin; C007740:fluorexon