title: Serum uric acid and components of the metabolic syndrome in non-diabetic populations in Mauritian Indians and Creoles and in Chinese in Qingdao, China.
abstract: OBJECTIVE
  To assess the association of serum uric acid (UA) with components of metabolic syndrome (MetS) in different ethnic groups.
  
  
  METHODS
  Nondiabetic men (3285) and nondiabetic women (4078) aged 25 to 74 years without a history of cardiovascular disease and gout from Mauritius and Qingdao China, comprising Mauritian Indians, Mauritian Creoles, and an urban Chinese population, were studied. The top quintile of waist circumference, body mass index (BMI), blood pressure, serum total cholesterol and triglycerides, plasma glucose levels, and the bottom quintile of HDL cholesterol was defined as the metabolic disorder. Hyperuricemia was defined if UA values were in the top quintile.
  
  
  RESULTS
  In a multivariate model (adjusted for age, cohort, smoking, and alcohol consumption), waist circumference, BMI, and serum triglycerides appeared to be independently associated with hyperuricemia in both sexes and in all ethnic groups except in Chinese women. Multivariate adjusted odds ratios (95% confidence intervals [CIs]) for having three or more metabolic disorders vs fewer than three, corresponding to a one SD increase in serum UA concentration, were 1.75 (1.51 to 2.02), 2.19 (1.71 to 2.82) and 2.30 (1.68 to 3.16) in Indian, Creole, and Chinese men, respectively, and 1.74 (1.52 to 2.00), 1.75 (1.40 to 2.19) and 1.72 (1.37 to 2.16) in Indian, Creole, and Chinese women, respectively.
  
  
  CONCLUSIONS
  In nondiabetics of Asian and African ancestry, elevated serum UA was closely associated with components of MetS, but whether UA provides additional information to the definition of the MetS in predicting future cardiovascular disease and diabetes needs to be studied.
authors: Department of Public Health, University of Helsinki, Helsinki, Finland. hairong.nan@helsinki.fi
authors: Hairong
authors: H
authors: Nan
authors: Qing
authors: Q
authors: Qiao
authors: Stefan
authors: S
authors: Söderberg
authors: Weiguo
authors: W
authors: Gao
authors: Paul
authors: P
authors: Zimmet
authors: Jonathan
authors: J
authors: Shaw
authors: George
authors: G
authors: Alberti
authors: Yanhu
authors: Y
authors: Dong
authors: Ulla
authors: U
authors: Uusitalo
authors: Vassen
authors: V
authors: Pauvaday
authors: Pierrot
authors: P
authors: Chitson
authors: Jaakko
authors: J
authors: Tuomilehto
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008055:Lipids / Q000097:blood; D008297:Male; D008436:Mauritius / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D011159:Population Surveillance; D014527:Uric Acid / Q000097:blood*; D044465:White People
chemical_list: D008055:Lipids; D014527:Uric Acid