Remission of metabolic syndrome: a study of 140 patients six months after Roux-en-Y gastric bypass.
BACKGROUND
Metabolic Syndrome (MS) is a complex disorder characterized by a number of cardiovascular risk factors usually associated with central fat deposition and insulin resistance. Nowadays, there are many different medical treatments to MS, including bariatric surgery, which improves all risk factors. The present study aims to evaluate the influence of gastric bypass in the improvement of risk factors associated with MS, during the postoperative (6 months).


METHODS
This was a retrospective study of 140 patients submitted to gastric bypass. The sample was comprised of a female majority (79.3 %). The mean body mass index (BMI) was 44.17 kg/m2. We evaluated the weight of the subjects, the presence of diabetes mellitus and hypertension as comorbidities, as well as plasma levels of triglycerides (TG), total cholesterol and its fractions, and glycemia, in both preoperative and postoperative.


RESULTS
The percentage of excess weight loss (%EWL) was similar in men and women, with an average of 67.82 +/- 13.21%. Concerning impaired fasting glucose (> or =100 mg/dl), 41 patients (95.3%) presented normal postoperative glycemia. There has been an improvement of every appraised parameter. The mean decrease in TG level was 66.33 mg/dl (p<0.0001). Before the surgery, 47.1% were hypertensive; after it, only 15% continued in antihypertensive drug therapy (p<0.0001). Otherwise, the only dissimilar variable between sexes was the high-density lipoprotein (HDL) level.


CONCLUSIONS
Gastric bypass is an effective method to improve the risk factors of metabolic syndrome in the morbidly obese.
Rossi
Marçal
M
RR Médicos e Cirurgiões, Clinic of Gastroenterology and Obesity Surgery, São Bernardo do Campo, São Paulo, Brazil. marcalrossi@uol.com.br
Barretto Fereira da Silva
Renato
R
Chaves Alcântara
Geraldo
G
Regina
Paulo Fernando
PF
Martin Bianco Rossi
Felipe
F
Serpa Neto
Ary
A
Zimberg Chehter
Ethel
E
D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009767:Obesity, Morbid / Q000453:epidemiology*; D011184:Postoperative Period; D012074:Remission Induction; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
D008075:Lipoproteins, HDL; D014280:Triglycerides