Radiative transport-based frequency-domain fluorescence tomography.
We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport solution-based fluorescence tomography algorithm is implemented on dual grids to efficiently assemble the measurement sensitivity Jacobian matrix. Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to microM fluorophore concentration distributions in simulated mouse organs.
Joshi
Amit
A
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA. amitj@bcm.edu
Rasmussen
John C
JC
Sevick-Muraca
Eva M
EM
Wareing
Todd A
TA
McGhee
John
J
D000465:Algorithms; D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D005453:Fluorescence; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D007668:Kidney / Q000473:pathology; D051379:Mice; D010363:Pattern Recognition, Automated; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D012984:Software; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*