title: Quantum dot nanobarcodes: epitaxial assembly of nanoparticle-polymer complexes in homogeneous solution.
abstract: Multiplexed nanobarcodes have been prepared with quantum dots (QDs) and alternating amphiphilic copolymers consisting of hydrocarbons and maleic anhydride groups. In homogeneous solution, the QD-polymer complexes grow epitaxially into nanobeads of narrow size dispersity, which has been previously achieved only for micrometer-sized beads in the presence of solid supports. As a result of this new nanostructure formation mechanism, more than 250 QDs can be loaded into a nanobead of 100 nm in diameter. A model assay for sensitive detection of human prostate specific antigen has also been demonstrated using the QD-nanobeads as fluorescent reporters. This nanoparticle-polymer self-assembly technology is capable of producing a variety of nanostructures and is expected to open new opportunities in nanoparticle-based ultrasensitive detection and imaging.
authors: Department of Bioengineering, University of Washington, William H. Foege Building N530M, Campus Box 355061, Seattle, Washington 98195, USA.
authors: Jian
authors: J
authors: Yang
authors: Shivang R
authors: SR
authors: Dave
authors: Xiaohu
authors: X
authors: Gao
mesh_terms: D003116:Color; D006801:Humans; D007118:Immunoassay; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000737:chemistry*; D017430:Prostate-Specific Antigen / Q000032:analysis / Q000737:chemistry; D045663:Quantum Dots; D012996:Solutions
chemical_list: D011108:Polymers; D012996:Solutions; D017430:Prostate-Specific Antigen