title: Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum.
abstract: This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
authors: Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia.
authors: Annika
authors: A
authors: Boxell
authors: Stephanie Hui Chin
authors: SH
authors: Lee
authors: Ryan
authors: R
authors: Jefferies
authors: Paul
authors: P
authors: Watt
authors: Richard
authors: R
authors: Hopkins
authors: Simon
authors: S
authors: Reid
authors: Anthony
authors: A
authors: Armson
authors: Una
authors: U
authors: Ryan
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D016785:Cryptosporidium parvum / Q000378:metabolism*; D004337:Drug Carriers; D019793:Fluorescein / Q000737:chemistry; D019476:Insect Proteins; D008856:Microscopy, Fluorescence; D010455:Peptides / Q000008:administration & dosage*
chemical_list: D023181:Antimicrobial Cationic Peptides; D000981:Antiprotozoal Agents; D004337:Drug Carriers; D019476:Insect Proteins; D010455:Peptides; C087710:pyrrhocoricin protein, Pyrrhocoris apterus; D019793:Fluorescein