title: Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy.
abstract: Q fever is a zoonotic infection caused by Coxiella burnetii. The most common clinical manifestation of acute Q fever infection is as an atypical community-acquired pneumonia. The pulmonary findings are accompanied by extrapulmonary findings, most typically an increase in serum transaminases and splenomegaly. Because C. burnetii is difficult to culture, the diagnosis of Q fever is usually made serologically. The diagnosis of acute Q fever atypical community-acquired pneumonia is made by demonstrating a fourfold or greater increase in titer between acute and convalescent specimens or by demonstrating elevated immunoglobulin (IgM) (phase II) titers. Chronic Q fever is manifested as granulomatous hepatitis or more commonly as culture-negative endocarditis (CNE). Chronic Q fever (CNE) is a difficult diagnosis because of difficulty in culturing the organism from the blood and the vegetations with Q fever CNE are small or absent. The diagnosis of chronic Q fever CNE is based on serology. Such patients commonly have highly elevated IgM and IgG titers (phase I/II) titers. Chronic Q fever CNE may involve native or prosthetic heart valves. Q fever prosthetic valve endocarditis is rare compared with native valve Q fever endocarditis. Q fever prosthetic valve endocarditis usually requires valve replacement for cure. We present a case of chronic Q fever bioprosthetic aortic valve endocarditis that was successfully treated with doxycycline monotherapy that did not require aortic valve replacement.
authors: Infectious Disease Division, Winthrop-University Hospital, Mineola, New York 11501, USA.
authors: Vitaliy
authors: V
authors: Krol
authors: Victoria
authors: V
authors: Kogan
authors: Burke A
authors: BA
authors: Cunha
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology* / Q000473:pathology; D002738:Chloroquine / Q000627:therapeutic use; D016997:Coxiella burnetii; D004318:Doxycycline / Q000627:therapeutic use*; D004696:Endocarditis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006349:Heart Valve Diseases / Q000188:drug therapy / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D011778:Q Fever / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002738:Chloroquine; D004318:Doxycycline