title: Immediate release tablets of telmisartan using superdisintegrant-formulation, evaluation and stability studies.
abstract: Telmisartan (anti-hypertensive) is insoluble in water; hence the drug may be slowly or incompletely dissolved in the gastro intestinal tract. So the rate of dissolution and therefore its bioavailability is less (bioavailability 42%). In the present study an attempt has been made to prepare immediate release tablets of telmisartan by using Polyplasdone XL-10 (Crosspovidone) at intragranular, extragranular and partly intra and extragranular level of addition to increase the rate of drug release from dosage form to increase the dissolution rate and hence its bioavailability. The prepared granules and tablets were evaluated for their physiochemical properties and in-vitro dissolution study was conducted for the prepared tablets. It was concluded that the immediate release tablets with proper hardness, disintegration time and with increase rate of dissolution can be made using Polyplasdone XL-10. Formuation-10 (F10) was selected for stability study and the in-vitro dissolution study showed that was no difference in percent of drug released between initial and sixth month sample.
authors: Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Tamil Nadu, India.
authors: Vasanthakumar
authors: V
authors: Sekar
authors: Vijaya Raghavan
authors: VR
authors: Chellan
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage* / Q000737:chemistry; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000737:chemistry; D001565:Benzoates / Q000008:administration & dosage* / Q000737:chemistry; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients; D011205:Povidone; D011208:Powders; D013607:Tablets; D000077333:Telmisartan; D013696:Temperature
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D005079:Excipients; D011208:Powders; D013607:Tablets; D011205:Povidone; D000077333:Telmisartan