Use of murine norovirus as a surrogate to evaluate resistance of human norovirus to disinfectants.
Murine norovirus (MNV) was used as a surrogate to study resistance of human norovirus to disinfectants used in hospitals. MNV was sensitive to alcohol, alcohol hand rubs, bleach, and povidone iodine-based disinfectant. Real-time reverse transcription-PCR results indicated that the presence of viral RNA did not correlate with the presence of infectious virus.
Belliot
Gaël
G
Laboratoire de Virologie, Centre National de Référence des Virus Entériques, Centre Hospitalier Universitaire de Dijon, 7 boulevard Jeanne d'Arc, 21079 Dijon Cedex, France. gael.belliot@u-bourgogne.fr
Lavaux
Amandine
A
Souihel
Donya
D
Agnello
Davide
D
Pothier
Pierre
P
D000818:Animals; D002460:Cell Line; D004202:Disinfectants / Q000494:pharmacology*; D008264:Macrophages / Q000821:virology; D051379:Mice; D050296:Microbial Viability; D029322:Norovirus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D012367:RNA, Viral / Q000235:genetics; D038301:Virus Inactivation / Q000187:drug effects*
D004202:Disinfectants; D012367:RNA, Viral