title: Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
abstract: Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.
authors: Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Suite 200, Chicago, IL 60611, USA. e-kim@northwestern.edu
authors: Eun-Young
authors: EY
authors: Kim
authors: Ronald S
authors: RS
authors: Veazey
authors: Roland
authors: R
authors: Zahn
authors: Kimberly J
authors: KJ
authors: McEvers
authors: Susanne H C
authors: SH
authors: Baumeister
authors: Gabriel J
authors: GJ
authors: Foster
authors: Melisa D
authors: MD
authors: Rett
authors: Michael H
authors: MH
authors: Newberg
authors: Marcelo J
authors: MJ
authors: Kuroda
authors: E Peter
authors: EP
authors: Rieber
authors: Michael
authors: M
authors: Piatak
authors: Jeffrey D
authors: JD
authors: Lifson
authors: Norman L
authors: NL
authors: Letvin
authors: Steven M
authors: SM
authors: Wolinsky
authors: Jörn E
authors: JE
authors: Schmitz
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015683:Gene Products, gag / Q000097:blood; D015696:Gene Products, tat / Q000097:blood; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology; D009154:Mutation / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014779:Virus Replication
chemical_list: D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015696:Gene Products, tat; D015395:Histocompatibility Antigens Class I; C110764:Mamu-A 01 antigen