Current progress of adhesins as vaccine candidates for Moraxella catarrhalis.
Moraxella catarrhalis is an emerging pathogen and all isolates are now considered beta-lactamase producing. Potential further use of vaccines against Streptococcus pneumoniae and nontypeable Haemophilus influenzae means that M. catarrhalis might be thrust further into the limelight. However, a vaccine has not yet been designed. In this review, the progress of M. catarrhalis adhesins as vaccine candidates is discussed with a focus on various candidate antigens that spanned those discovered more than 10 years ago, for example, the ubiquitous surface proteins to newer antigens, such as the Moraxella IgD-binding hemagglutinin.
Tan
Thuan Tong
TT
Malmö University Hospital, Medical Microbiology, Department of Laboratory Medicine, Lund University, SE-205 02 Malmö, Sweden. tan.thuan.tong@sgh.com.sg
Riesbeck
Kristian
K
D018829:Adhesins, Bacterial / Q000276:immunology* / Q000627:therapeutic use*; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D001936:Moraxella catarrhalis / Q000276:immunology*; D045828:Moraxellaceae Infections / Q000276:immunology / Q000517:prevention & control*
D018829:Adhesins, Bacterial; D001428:Bacterial Vaccines