title: Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors.
abstract: A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.
authors: The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA. shuang2@gnf.org
authors: Shenlin
authors: S
authors: Huang
authors: Zuosheng
authors: Z
authors: Liu
authors: Shin-Shay
authors: SS
authors: Tian
authors: Mark
authors: M
authors: Sandberg
authors: Tracy A
authors: TA
authors: Spalding
authors: Russell
authors: R
authors: Romeo
authors: Maya
authors: M
authors: Iskandar
authors: Zhiliang
authors: Z
authors: Wang
authors: Donald
authors: D
authors: Karanewsky
authors: Yun
authors: Y
authors: He
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D001665:Binding Sites; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D051379:Mice; D008956:Models, Chemical; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D001549:Benzamides; D052160:Benzothiazoles; D047428:Protein Kinase Inhibitors; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)