Neurogenesis directed by Sirt1.
Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
Libert
Sergiy
S
Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Cohen
Dena
D
Guarente
Leonard
L
D000818:Animals; D001253:Astrocytes / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000166:cytology / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000235:genetics; D051379:Mice; D009474:Neurons / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D013234:Stem Cells / Q000502:physiology*
D051792:Basic Helix-Loop-Helix Proteins; D056564:Sirtuin 1; D037761:Sirtuins; C499317:Ascl1 protein, mouse; C470545:Sirt1 protein, mouse