title: An iodoetherification-dehydroiodination strategy for the synthesis of complex spiroketals from dihydroxyalkene precursors.
abstract: Dihydroxyalkenes or their monoprotected alcohol derivatives are transformed to 5,5- and 5,6-spiroketals through a sequence involving an initial iodocyclization, followed by a silver triflate mediated spiroketalization step on the derived hydroxy-iodoether.
authors: Department of Chemistry, Hunter College/CUNY, New York, NY 10021, USA.
authors: K A
authors: KA
authors: Tony
authors: Xiaohua
authors: X
authors: Li
authors: Darrin
authors: D
authors: Dabideen
authors: Jialiang
authors: J
authors: Li
authors: David R
authors: DR
authors: Mootoo
mesh_terms: D003500:Cyclization; D003516:Cycloparaffins / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D054879:Halogenation; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003516:Cycloparaffins; D004987:Ethers; D005663:Furans; D006847:Hydrocarbons, Iodinated; D013141:Spiro Compounds; C520774:spiroketal