Lack of effect of aerobic physical exercise on endothelium-derived nitric oxide concentrations in healthy young subjects.
Previous experimental research showed an attenuated vasoconstrictor response after acute exercise. This study aims to determine the effect of aerobic physical exercise on the endothelium-derived circulating nitric oxide (NO) concentrations among healthy young persons. A total of 10 subjects (5 men and 5 women) aged 21-28 were examined for the difference in concentrations of serum and plasma NO metabolites (NOx) before and after a single bout of aerobics, in which they performed cycling exercises at a constant workload corresponding to 90% of the subject-specific anaerobic threshold. A paired t-test resulted in no statistically significant differences between pre- and post-exercise concentrations of serum or plasma NOx. It is suggested that the acute effect of aerobic exercise on the vasoconstrictor/vasodilator response is not mediated by an increase in the endothelial NO release.
Yamamoto
Kanami
K
Program in Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Japan.
Kondo
Takaaki
T
Kimata
Akiko
A
Ueyama
Jun
J
Shirotori
Aya
A
Okada
Yoshiko
Y
Sakui
Daisuke
D
Nakashima
Masahiro
M
Yamada
Sumio
S
D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D014661:Vasoconstriction / Q000502:physiology
D009569:Nitric Oxide