Fidelity of gamma-glutamyl transferase (GGT) in differentiating skeletal muscle from liver damage.
This study tested the hypothesis that gamma-glutamyl transferase (GGT) can be used as a reliable biomarker to distinguish skeletal muscle from liver damage. Twenty-eight Duchenne muscular dystrophy subjects with proven dystrophin gene mutations were enrolled. Included were 14 ambulatory and 14 nonambulatory patients with approximately half of each cohort taking corticosteroids. Twenty normal males served as controls. Initial blood samples for serum GGT and creatine kinase were taken between 8AM and 9AM and redrawn 8 hours later to test for variability. Between blood draws, subjects resumed normal activities in a play environment or could leave the clinic. Not a single duchenne muscular dystrophy patient showed a GGT outside the control range at any time point, while creatine kinase levels were 14 to 200 times normal. Validation of this finding is essential for management of patients with muscle disorders exposed to potentially hepatotoxic drugs for clinical management or monitoring subjects participating in clinical trials.
Rosales
Xiomara Q
XQ
Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Chu
Mary-Lynn
ML
Shilling
Christopher
C
Wall
Cheryl
C
Pastores
Gregory M
GM
Mendell
Jerry R
JR
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D020388:Muscular Dystrophy, Duchenne / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000097:blood*
D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D003402:Creatine Kinase