title: Impact of GnRH agonist treatment on recurrence of ovarian endometriomas after conservative laparoscopic surgery.
abstract: OBJECTIVE
  To analyze the influence of postoperative GnRH agonist treatment on disease recurrence after conservative laparoscopic surgery for ovarian endometriomas according to duration of the treatment.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  One hundred nine consecutive premenopausal women who underwent conservative laparoscopic surgery for ovarian endometriomas (endometriosis stage III/IV) were enrolled in the study. The patients were divided into four treatment groups: expectant management (n = 37) and GnRH agonist therapy for 3 (n = 28), 4 (n = 21), and 6 months (n = 23).
  
  
  METHODS
  None.
  
  
  METHODS
  An ultrasound confirmed recurrence of ovarian endometriomas.
  
  
  RESULTS
  The overall crude recurrence rate was 16.5% after follow-up for an average of 20.1 months. The crude recurrence and the cumulative probabilities of disease recurrence at 24/36 months tended to be lower in patients who received a GnRH agonist for 6 months (4.3%, 5.3%/5.3%) compared with those who received it for 3 months (17.9%, 12.5%/25.0%) and 4 months (28.6%, 18.9%/39.2%) and patients with expectant management (16.2%, 22.4%/37.9%). However, the differences did not reach statistical significance.
  
  
  CONCLUSIONS
  Treatment with GnRH agonist for six months had a beneficial impact on the recurrence rate after conservative laparoscopic surgery for ovarian endometriomas.
authors: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors: Byung Chul
authors: BC
authors: Jee
authors: Joong Yeup
authors: JY
authors: Lee
authors: Chang Suk
authors: CS
authors: Suh
authors: Seok Hyun
authors: SH
authors: Kim
authors: Young Min
authors: YM
authors: Choi
authors: Shin Yong
authors: SY
authors: Moon
mesh_terms: D003131:Combined Modality Therapy; D004715:Endometriosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007723:Korea; D010535:Laparoscopy; D011336:Probability; D012008:Recurrence; D013997:Time Factors
chemical_list: D007987:Gonadotropin-Releasing Hormone