title: New Paracoccidioides brasiliensis isolate reveals unexpected genomic variability in this human pathogen.
abstract: By means of genealogical concordance phylogenetic species recognition (GCPSR), we have investigated coding and non-coding regions from various genes and the ITS sequences of 7 new and 14 known isolates of Paracoccidioides brasiliensis. Such isolates grouped within the three phylogenetic groups recently reported in the genus Paracoccidioides, with one single exception, i.e., Pb01, a strain that has been the subject of intense molecular studies for many years. This isolate clearly separates from all other Paracoccidioides isolates in phylogenetic analyses and greatly increases the genomic variation known in this genus.
authors: Instituto Venezolano de Investigaciones Científicas, Laboratorio de Micología, P.O. Box 21827, Caracas, Venezuela.
authors: Lilia L
authors: LL
authors: Carrero
authors: Gustavo
authors: G
authors: Niño-Vega
authors: Marcus M
authors: MM
authors: Teixeira
authors: Maria Jose A
authors: MJ
authors: Carvalho
authors: Célia M A
authors: CM
authors: Soares
authors: Maristela
authors: M
authors: Pereira
authors: Rosália S A
authors: RS
authors: Jesuino
authors: Juan G
authors: JG
authors: McEwen
authors: Leonel
authors: L
authors: Mendoza
authors: John W
authors: JW
authors: Taylor
authors: Maria Sueli
authors: MS
authors: Felipe
authors: Gioconda
authors: G
authors: San-Blas
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010228:Paracoccidioides / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010229:Paracoccidioidomycosis / Q000382:microbiology; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D012988:Soil Microbiology
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer