title: The orexigenic effect of GnIH is mediated by central opioid receptors in chicks.
abstract: Gonadotropin-inhibiting hormone (GnIH) is a newly discovered hypothalamic hormone which suppresses gonadotropin synthesis and release from the anterior pituitary. Recently, we found that intracerebroventricular (ICV) injection of GnIH stimulated feeding behavior of chicks (Gallus gallus) and suggested that GnIH is one of orexigenic peptides. However, the mechanism underlying the orexigenic effect is still unknown. In the present study, we examined whether the orexigenic effect of GnIH is related to opioid and nitric oxide (NO) systems. The orexigenic effect of ICV-injected GnIH was attenuated by co-injection of beta-funaltrexamine (an opioid mu-receptor antagonist) but not ICI-174,864 and nor-binaltorphimine (antagonists of opioid delta- and kappa-receptors, respectively). The co-injection of non-selective NO synthase inhibitor did not affect GnIH-induced feeding behavior. The present study demonstrated that the GnIH-induced feeding might be mediated by opioid mu-receptor in chicks.
authors: Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan. tetsu@agr.ehime-u.ac.jp
authors: Tetsuya
authors: T
authors: Tachibana
authors: Naoto
authors: N
authors: Masuda
authors: Kazuyoshi
authors: K
authors: Tsutsui
authors: Kazuyoshi
authors: K
authors: Ukena
authors: Hiroshi
authors: H
authors: Ueda
mesh_terms: D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects; D007028:Hypothalamic Hormones / Q000494:pharmacology*; D007267:Injections; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009292:Narcotic Antagonists; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D007028:Hypothalamic Hormones; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester