Cibenzoline intoxication: effect of combined hemoperfusion-hemodialysis on plasma clearance.
BACKGROUND
Cibenzoline is an antiarrhythmic drug used to treat patients with supraventricular or ventricular arrhythmias. Cibenzoline overdose is associated with proarrhythmic and hemodynamic effects such as hypotension and congestive heart failure.


METHODS
We report a case of cardiogenic shock due to cibenzoline overdose in a patient with progressive renal insufficiency.


CONCLUSIONS
The standard treatment of a cibenzoline intoxication is symptomatic, but we used combined hemoperfusion-hemodialysis to treat our patient.


CONCLUSIONS
This was associated with a rapid decline in plasma cibenzoline concentration and improvement of the clinical condition. However, only 28.98 mg of an estimated body pool of cibenzoline (447.2 to 806.6 mg) was removed during the 8 hours of treatment.
Meeus
Roel
R
Department of Critical Care Medicine, University Hospital of Antwerp, Edegem, Belgium.
Verpooten
Gert A
GA
De Paep
Rudi
R
Paelinck
Bernard P
BP
Neels
Hugo
H
Cooreman
Sarah
S
De Doncker
Mireiile
M
Jorens
Philippe G
PG
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D001281:Atrial Fibrillation / Q000188:drug therapy; D062787:Drug Overdose; D005260:Female; D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D007674:Kidney Diseases / Q000139:chemically induced* / Q000628:therapy; D006435:Renal Dialysis; D051437:Renal Insufficiency; D012770:Shock, Cardiogenic / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; C032151:cifenline