title: A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid.
abstract: Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.
authors: School of Chemistry, University of Tasmania, Private Bag 75, Hobart, Tasmania 7001, Australia. .
authors: Ruth I J
authors: RI
authors: Amos
authors: Brendon S
authors: BS
authors: Gourlay
authors: Carl H
authors: CH
authors: Schiesser
authors: Jason A
authors: JA
authors: Smith
authors: Brian F
authors: BF
authors: Yates
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D007538:Isoniazid / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000995:Antitubercular Agents; D006834:Hydrazines; D007538:Isoniazid