title: The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation.
abstract: Phenotypic analysis of a constructed RNase III null mutant of Streptomyces coelicolor revealed that RNase III is required for both antibiotic production and proper formation of sporulation septa. Transcriptional analysis of the gene encoding RNase III indicated that it is transcribed exclusively during exponential phase as part of a tricistronic message.
authors: Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Colney, NR4 7UH Norwich, United Kingdom. jason_sello@brown.edu
authors: Jason K
authors: JK
authors: Sello
authors: Mark J
authors: MJ
authors: Buttner
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D009154:Mutation; D010641:Phenotype; D043244:Ribonuclease III / Q000235:genetics* / Q000378:metabolism*; D013171:Spores, Bacterial / Q000502:physiology; D048372:Streptomyces coelicolor / Q000235:genetics / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D043244:Ribonuclease III