title: Hemodynamic alterations during orthotopic liver experimental transplantation in pigs.
abstract: OBJECTIVE
  To describe the hemodynamic alterations during orthotopic liver transplantation in pigs.
  
  
  METHODS
  In the period from April 2004 to December 2005, forty-four female Landrace pigs, weighting between 32 and 38 Kg underwent orthotopic liver transplantation. The animals were divided into two groups, donor and recipient pairs, which received whole liver grafts. The surgical procedure was divided into four parts: harvested, back-table, hepatectomy of the recipient and implantation. We analyzed heart rate, blood gas, mean systemic arterial pressure (MAP-mmHg), central venous pressure, pH, Na-, K+, Cl-, Ca+ and urinary output.
  
  
  RESULTS
  The mean anhepatic time was 69 min, cold ischemia was 252.2 min and back-table was 56.6 min. Blood pressure and heart rate dropped significantly during anhepatic phase and after revascularization. Blood gas and electrolytes alterations were observed during anhepatic and reperfusion phases. Although alterations were noted during these phases, the hemodynamic status was recovered and stabilized in the end of the surgery.
  
  
  CONCLUSIONS
  Simplified technique of liver transplant was achieved and description of hemodynamic alterations was possible in pigs.
authors: Department of Surgery, Federal University of Maranhão, Brazil. o.torres@uol.com.br
authors: Orlando Jorge Martins
authors: OJ
authors: Torres
authors: Patrícia Brandão
authors: PB
authors: Pantoja
authors: Erica Sampaio
authors: ES
authors: Barbosa
authors: Cristiany de Almeida
authors: Cde A
authors: Barros
authors: Elizabeth Teixeira Noguera
authors: ET
authors: Servin
authors: Santiago Cirilo Noguera
authors: SC
authors: Servin
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D004573:Electrolytes / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D016031:Liver Transplantation / Q000502:physiology*; D013552:Swine
chemical_list: D004573:Electrolytes