title: Hand-foot syndrome with sclerodactyly-like changes in a patient treated with capecitabine.
abstract: Capecitabine, a fluoropyrimidine carbamate with antineoplastic activity, is an oral agent that was developed as a prodrug of 5-fluorouracil and is used in the treatment of metastatic colorectal and breast cancers. Multiple cutaneous adverse effects had been described with the use of this drug, but to our knowledge, specific association with capecitabine and hand-foot syndrome with sclerodactyly-like changes has been described only once. We report a patient with a colon adenocarcinoma who presented with hand-foot syndrome, with sclerodactyly-like changes induced by capecitabine.
authors: Department of Dermatology, Hospital dos Capuchos, Lisbon, Portugal. felicidade.trindade@gmail.com
authors: Felicidade
authors: F
authors: Trindade
authors: Rosario
authors: R
authors: Haro
authors: Maria Carmen
authors: MC
authors: Fariña
authors: Luis
authors: L
authors: Requena
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D000284:Administration, Oral; D001707:Biopsy, Needle; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology*; D012720:Severity of Illness Index; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome
chemical_list: D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil