title: Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.
abstract: SAR around alkyne-quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.
authors: UCB, R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium.
authors: Jean-Philippe
authors: JP
authors: Starck
authors: Laurent
authors: L
authors: Provins
authors: Bernard
authors: B
authors: Christophe
authors: Michel
authors: M
authors: Gillard
authors: Sophie
authors: S
authors: Jadot
authors: Patrick
authors: P
authors: Lo Brutto
authors: Luc
authors: L
authors: Quéré
authors: Patrice
authors: P
authors: Talaga
authors: Michel
authors: M
authors: Guyaux
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D018680:Cholinergic Antagonists / Q000737:chemistry; D015394:Molecular Structure; D018727:Muscarinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D011812:Quinuclidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D043585:Receptor, Muscarinic M2 / Q000378:metabolism; D043587:Receptor, Muscarinic M3 / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000480:Alkynes; D018680:Cholinergic Antagonists; D018727:Muscarinic Antagonists; D011812:Quinuclidines; D043585:Receptor, Muscarinic M2; D043587:Receptor, Muscarinic M3