Current pharmacologic treatment for orthostatic hypotension.
Orthostatic hypotension is treated effectively with the combined use of non-pharmacological and pharmacological interventions. Patients should be counseled as to the nature of the underlying disorder and reversible causes of orthostatic hypotension should be removed. Should symptoms persist, pharmacological treatment is implemented. First line pharmacotherapeutic interventions include volume repletion in combination with alpha-adrenoreceptor agonists. If unsuccessful there are several supplementary agents with different mechanisms of action that may provide an additive effect.
Freeman
Roy
R
Dept. of Neurology Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA. rfreeman@bidmc.harvard.edu
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy* / Q000503:physiopathology; D013566:Sympathomimetics / Q000627:therapeutic use; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D014667:Vasopressins / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D018765:Dopamine Uptake Inhibitors; D004791:Enzyme Inhibitors; D013566:Sympathomimetics; D014662:Vasoconstrictor Agents; D014667:Vasopressins; D005438:Fludrocortisone