title: Rhodamine-based fluorogenic probe for imaging biological thiol.
abstract: We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modification of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells.
authors: Nano Medical Engineering Laboratory Discovery Research Institute, RIKEN 2-1, Hirosawa, Wako-Shi, Saitama 351-0198, Japan.
authors: Aya
authors: A
authors: Shibata
authors: Kazuhiro
authors: K
authors: Furukawa
authors: Hiroshi
authors: H
authors: Abe
authors: Satoshi
authors: S
authors: Tsuneda
authors: Yoshihiro
authors: Y
authors: Ito
mesh_terms: D001557:Benzenesulfonates / Q000737:chemistry; D002460:Cell Line; D003545:Cysteine / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D019793:Fluorescein / Q000138:chemical synthesis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D008956:Models, Chemical; D012235:Rhodamines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D001557:Benzenesulfonates; D005456:Fluorescent Dyes; D012235:Rhodamines; D013438:Sulfhydryl Compounds; C049025:rhodamine 110; D005978:Glutathione; D003545:Cysteine; D019793:Fluorescein