Riding the waves: neural and nonneural origins for mesenchymal stem cells.
The role of endogenous mesenchymal stem cells (MSCs) is enigmatic. Recently in Cell, Takashima et al. (2007) addressed the biological origin of MSCs and showed that they are generated in waves, with the neuroepithelium unexpectedly providing the first wave and a second wave of nonneural-derived MSCs taking precedence in the adult.
Miller
Freda D
FD
Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. fredam@sickkids.ca
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008648:Mesoderm / Q000166:cytology; D051379:Mice; D009432:Neural Crest / Q000166:cytology*; D046569:Neuroepithelial Cells / Q000166:cytology*