title: Variations in the FTO gene are associated with severe obesity in the Japanese.
abstract: Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) > or = 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.
authors: Laboratory for Obesity, SNP Research Center, RIKEN, 1-7-22 Suehiro, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. kikuko@src.riken.jp.
authors: Kikuko
authors: K
authors: Hotta
authors: Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
authors: Yoshio
authors: Y
authors: Nakata
authors: Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
authors: Tomoaki
authors: T
authors: Matsuo
authors: Medicine and Health Science Institute, Tokyo Medical University, Tokyo, Japan.
authors: Seika
authors: S
authors: Kamohara
authors: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Kazuaki
authors: K
authors: Kotani
authors: Rinku General Medical Center, Osaka, Japan.
authors: Ryoya
authors: R
authors: Komatsu
authors: Toyonaka Municipal Hospital, Osaka, Japan.
authors: Naoto
authors: N
authors: Itoh
authors: Otemae Hospital, Osaka, Japan.
authors: Ikuo
authors: I
authors: Mineo
authors: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
authors: Jun
authors: J
authors: Wada
authors: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Hiroaki
authors: H
authors: Masuzaki
authors: Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Masato
authors: M
authors: Yoneda
authors: Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Atsushi
authors: A
authors: Nakajima
authors: Tokyo Postal Services Agency Hospital, Tokyo, Japan.
authors: Shigeru
authors: S
authors: Miyazaki
authors: Itami City Hospital, Hyogo, Japan.
authors: Katsuto
authors: K
authors: Tokunaga
authors: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Manabu
authors: M
authors: Kawamoto
authors: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Tohru
authors: T
authors: Funahashi
authors: Department of Community Health and Gerontological Nursing, Faculty of Medicine, Oita University, Oita, Japan.
authors: Kazuyuki
authors: K
authors: Hamaguchi
authors: Division of Endocrinology and Metabolism, Department of Medicine, Kurume University, Fukuoka, Japan.
authors: Kentaro
authors: K
authors: Yamada
authors: First Department of Internal Medicine, Osaka Medical College, Osaka, Japan.
authors: Toshiaki
authors: T
authors: Hanafusa
authors: Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School, Tokyo, Japan.
authors: Shinichi
authors: S
authors: Oikawa
authors: Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan.
authors: Hironobu
authors: H
authors: Yoshimatsu
authors: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Kazuwa
authors: K
authors: Nakao
authors: Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan.
authors: Toshiie
authors: T
authors: Sakata
authors: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Yuji
authors: Y
authors: Matsuzawa
authors: Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
authors: Kiyoji
authors: K
authors: Tanaka
authors: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.|Laboratory for Statistical Analysis, SNP Research Center, RIKEN, Tokyo, Japan.
authors: Naoyuki
authors: N
authors: Kamatani
authors: Laboratory for Molecular Medicine, Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors: Yusuke
authors: Y
authors: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human