A prospective, randomized, double-blind comparison of articaine and lidocaine for maxillary infiltrations.
The purpose of this prospective, randomized, double-blind crossover study was to evaluate the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine in maxillary lateral incisors and first molars. Eighty subjects randomly received, in a double-blind manner, maxillary lateral incisor and first molar infiltrations of one cartridge of 4% articaine with 1:100,000 epinephrine or 2% lidocaine with 1:100,000 epinephrine at two separate appointments spaced at least 1 week apart. In maxillary lateral incisors, articaine exhibited a significantly higher anesthetic success rate of 88% when compared with a 62% success rate with lidocaine. In maxillary first molars, articaine had a similar success rate to lidocaine (78% vs 73%), and there was no significant difference between the two solutions. In conclusion, a maxillary infiltration of 4% articaine with 1:100,000 epinephrine statistically improved anesthetic success when compared with 2% lidocaine with 1:100,000 epinephrine in the lateral incisor but not in the first molar.
Evans
Grace
G
Division of Endodontics, The Ohio State University, Columbus, USA.
Nusstein
John
J
Drum
Melissa
M
Reader
Al
A
Beck
Mike
M
D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002355:Carticaine / Q000008:administration & dosage*; D018592:Cross-Over Studies; D003791:Dental Pulp Test; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007180:Incisor; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008437:Maxilla; D008963:Molar; D011446:Prospective Studies
D000779:Anesthetics, Local; D008012:Lidocaine; D002355:Carticaine