The eukaryotic genome as an RNA machine.
The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.
Amaral
Paulo P
PP
Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia.
Dinger
Marcel E
ME
Mercer
Tim R
TR
Mattick
John S
JS
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D016678:Genome; D015894:Genome, Human; D006801:Humans; D014176:Protein Biosynthesis; D012323:RNA Processing, Post-Transcriptional; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D022661:RNA, Untranslated