Stem cell epigenetics: is it all downhill from here?
In this issue of Cell Stem Cell, Fasano et al. (2007) investigate the role of Bmi-1 in neural stem cells in vitro and in vivo. They find a progressively increasing requirement for Bmi-1 function in stem cells during development that, surprisingly, seems to involve regulation of the cell-cycle inhibitor p21.
McKay
Ron
R
LMB/NINDS, Bethesda, MD 20892-4157, USA. Electronic address: mckayr@ninds.nih.gov.
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D044127:Epigenesis, Genetic; D016158:Genes, p53; D051379:Mice; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics; D015689:Oncogene Protein p21(ras) / Q000235:genetics; D063150:Polycomb Repressive Complex 1; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D013234:Stem Cells / Q000166:cytology*
C489421:Bmi1 protein, mouse; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C066476:Pcgf6 protein, mouse; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D063150:Polycomb Repressive Complex 1; D015689:Oncogene Protein p21(ras)