title: Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals.
abstract: OBJECTIVE
  Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals.
  
  
  METHODS
  We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects.
  
  
  RESULTS
  The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load.
  
  
  CONCLUSIONS
  Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
authors: Cardiology Research Clinic Y, Bispebjerg University Hospital, 2400 Copenhagen, NV, Denmark. atmp@heart.dk
authors: A
authors: A
authors: Major-Pedersen
authors: N
authors: N
authors: Ihlemann
authors: T S
authors: TS
authors: Hermann
authors: B
authors: B
authors: Christiansen
authors: H
authors: H
authors: Dominguez
authors: B
authors: B
authors: Kveiborg
authors: D B
authors: DB
authors: Nielsen
authors: O L
authors: OL
authors: Svendsen
authors: L
authors: L
authors: Køber
authors: C
authors: C
authors: Torp-Pedersen
mesh_terms: D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D010919:Placebos; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010919:Placebos; D005947:Glucose