title: Is there a risk of harm or toxicity in the placement of pit and fissure sealant materials? A systematic review.
abstract: BACKGROUND
  Recently, there has been increased interest in the in vivo release of dental sealant components, such as bisphenol A (BPA), which has the potential to bind the estrogen receptors of relevant cells at subtoxic concentrations in vitro, impairing the development, health and reproductive systems of wildlife. The purpose of this systematic review was to investigate whether the placement of pit and fissure sealant materials causes toxicity, and thus harms patients.
  
  
  METHODS
  The literature search (from the earliest record up to March 2007) for relevant articles was done with Ovid MEDLINE, CINAHL and other bibliographic databases.
  
  
  RESULTS
  A total of 377 articles were identified by the literature search; relevance was determined by examining the title and abstract of the articles. Eleven original studies met the inclusion criteria. These articles were read in full and scored independently by 2 reviewers.
  
  
  CONCLUSIONS
  The evidence suggests that patients are not at risk for exposure to BPA from the use of dental sealants. To reduce the potential, if any, for BPA toxicity from sealants, dental providers should use a mild abrasive, such as pumice, either on a cotton applicator or in a prophy cup; have older children and adolescents gargle with tepid water for 30 seconds; or wash the sealant surface for 30 seconds with an air-water syringe while suctioning fluids and debris from a child"s mouth.
authors: Department of Endodontics, Community Dental Health Services Research Unit, Faculty of Dentistry, University of Toronto, Toronto, Ontario. amir.azarpazhooh@dentistry.utoronto.ca
authors: Amir
authors: A
authors: Azarpazhooh
authors: Patricia A
authors: PA
authors: Main
mesh_terms: D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds; D017438:Bisphenol A-Glycidyl Methacrylate / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D002648:Child; D004968:Estrogens, Non-Steroidal / Q000032:analysis; D006801:Humans; D010636:Phenols / Q000032:analysis; D010895:Pit and Fissure Sealants / Q000737:chemistry / Q000633:toxicity*; D017640:Silicates; D013499:Surface Properties; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D017438:Bisphenol A-Glycidyl Methacrylate; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D010895:Pit and Fissure Sealants; D017640:Silicates; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C005144:pumice