Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.
4'-Modified noraristeromycin (NAM) analogs, 4'-sulfo-, 4'-sulfamoy, 4'-azido and 4'-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl-L-homocysteine hydrolase were investigated.
Ando
Takayuki
T
Center for Emerging Infectious Diseases, Department of Biomolecular Science, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.
Kojima
Kenji
K
Chahota
Praveen
P
Kozaki
Atsushi
A
Milind
Nikalje D
ND
Kitade
Yukio
Y
D000241:Adenosine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006900:Hydroxylation; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000201:enzymology; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D043383:Adenosylhomocysteinase; D000241:Adenosine