title: Evidence of exacerbated cognitive deficits in schizophrenia patients with comorbid diabetes.
abstract: Type 2 diabetes is associated with both schizophrenia and cognitive performance. The authors compared cognitive performance in three groups: patients with schizophrenia and diabetes, patients with diabetes only, and patients with schizophrenia only. Results indicated that the schizophrenia/diabetes group was impaired cognitively relative to both other groups, especially in the domains of processing speed and visual/spatial ability. Also, these impairments were associated with diabetes severity markers. Because either illness creates cognitive vulnerability, comorbid occurrence is even more likely to undermine essential functional brain systems, leading to an increased rate and magnitude of cognitive decline with associated declines in community functioning.
authors: VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore, MD 21201, USA. Dwight.Dickinson@va.gov
authors: Dwight
authors: D
authors: Dickinson
authors: James M
authors: JM
authors: Gold
authors: Faith B
authors: FB
authors: Dickerson
authors: Deborah
authors: D
authors: Medoff
authors: Lisa B
authors: LB
authors: Dixon
mesh_terms: D000328:Adult; D001076:Aptitude; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000523:psychology; D009483:Neuropsychological Tests; D009949:Orientation; D011597:Psychomotor Performance; D011930:Reaction Time; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology