Short-circuiting epiblast development.
Although human and mouse embryonic stem cells share many characteristics, their behaviors are not identical. Two recent papers describe the derivation of stem cell lines from mouse epiblast that may provide an explanation for the unique character of human embryonic stem cells.
Eggan
Kevin
K
The Stowers Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. eggan@mcb.harvard.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology*; D005855:Germ Layers / Q000166:cytology*; D006801:Humans; D051379:Mice