SKNy worms and long life.
Interactions between insulin signaling and stress-response pathways can markedly impact life span. In this issue, Tullet et al. (2008) demonstrate that the worm homolog of Nrf2, called SKN-1, a transcription factor that switches on expression of antioxidant genes, is an important component of such signaling interactions.
Jasper
Heinrich
H
Department of Biology, University of Rochester, Rochester, NY 14627, USA. henri_jasper@urmc.rochester.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D053263:Gene Regulatory Networks; D007328:Insulin / Q000378:metabolism; D008136:Longevity; D018384:Oxidative Stress; D013002:Somatomedins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D007328:Insulin; D013002:Somatomedins; D014157:Transcription Factors; C073702:skn-1 protein, C elegans