[Experimental study of the neuroprotective properties of the melanin in embryos irradiated during antenatal development].
Daily introduction per os of the exogenous melanin in a doze of weight of 10 mg/kg pregnant female rats of line Wistar on a background continuous irradiations (dose rate of 2.6 mGy/h within 20 days of pregnancy) eliminated deficiency cognitive functions at posterity. On the basis of the received data it is concluded presence radioembryoprotective actions of melanin in the relation neuro embryotoxic effects of small dozes ionizing radiation. Taking into account small toxicity of melanin, the preparation can be perspective for practical application.
Izmest'eva
O S
OS
Dubovik
B V
BV
Zhavoronkov
L P
LP
Pavlova
L N
LN
Semin
Iu A
IuA
Izmest'ev
V I
VI
Posadskaia
V M
VM
D000284:Administration, Oral; D000818:Animals; D047108:Embryonic Development / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D007858:Learning / Q000187:drug effects / Q000528:radiation effects; D008543:Melanins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009420:Nervous System / Q000187:drug effects / Q000196:embryology / Q000528:radiation effects; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D008543:Melanins; D018696:Neuroprotective Agents; D011837:Radiation-Protective Agents