title: Leser-Trelat sign in metastasized malignant melanoma.
abstract: The Leser-Trelat sign is defined as the association of multiple, eruptive seborrheic keratoses with an internal malignancy of a usually advanced stage. We report the case of malignant melanoma in an 82-year-old man covered with hundreds of greyish-dark seborrheic keratoses resembling a Christmas tree pattern, who was diagnosed with metastasized malignant melanoma involving the parotid gland and lymph nodes. Though the pathogenesis of Leser-Trelat sign is still unknown, spontaneous regression of the seborrheic keratoses following tumor reduction described in some cases argues for a paraneoplastic origin of this highly instructive clinical entity. Physicians should consider a workup for internal malignancy in patients presenting with multiple eruptive seborrheic keratoses.
authors: Department of Otorhinolaryngology, Ludwig-Maximilian University, Marchioninistr. 15, 81377 Munich, Germany. vanessa.siedek@med.uni-muenchen.de
authors: Vanessa
authors: V
authors: Siedek
authors: Theda
authors: T
authors: Schuh
authors: Andreas
authors: A
authors: Wollenberg
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D003606:Dacarbazine / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D017492:Keratosis, Seborrheic / Q000188:drug therapy / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary*; D009367:Neoplasm Staging; D010166:Palliative Care / Q000379:methods; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000473:pathology*; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D003606:Dacarbazine