title: Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective.
abstract: Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis-Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.
authors: Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA. cathy.petti@aruplab.com
authors: Cathy A
authors: CA
authors: Petti
authors: Keith E
authors: KE
authors: Simmon
authors: Jose M
authors: JM
authors: Miro
authors: Bruno
authors: B
authors: Hoen
authors: Francesc
authors: F
authors: Marco
authors: Vivian H
authors: VH
authors: Chu
authors: Eugene
authors: E
authors: Athan
authors: Suzana
authors: S
authors: Bukovski
authors: Emilio
authors: E
authors: Bouza
authors: Suzanne
authors: S
authors: Bradley
authors: Vance G
authors: VG
authors: Fowler
authors: Efthymia
authors: E
authors: Giannitsioti
authors: David
authors: D
authors: Gordon
authors: Porl
authors: P
authors: Reinbott
authors: Tony
authors: T
authors: Korman
authors: Selwyn
authors: S
authors: Lang
authors: Cristina
authors: C
authors: Garcia-de-la-Maria
authors: Annibale
authors: A
authors: Raglio
authors: Arthur J
authors: AJ
authors: Morris
authors: Patrick
authors: P
authors: Plesiat
authors: Suzanne
authors: S
authors: Ryan
authors: Thanh
authors: T
authors: Doco-Lecompte
authors: Francesca
authors: F
authors: Tripodi
authors: Riccardo
authors: R
authors: Utili
authors: Dannah
authors: D
authors: Wray
authors: J Jeffrey
authors: JJ
authors: Federspiel
authors: K
authors: K
authors: Boisson
authors: L Barth
authors: LB
authors: Reller
authors: David R
authors: DR
authors: Murdoch
authors: Christopher W
authors: CW
authors: Woods
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D003030:Coagulase / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004697:Endocarditis, Bacterial / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010444:Peptide Elongation Factor Tu / Q000235:genetics; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013210:Staphylococcus / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D003030:Coagulase; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; D010444:Peptide Elongation Factor Tu