MAPK-ing out the pathways in lung stem cell regulation.
Methods to isolate and characterize stem cell populations from the lung are emerging, making it possible to begin to map out the pathways that are required for stem cell function in the adult lung. A new study by Ventura et al. (2007) points to a requirement for MAPK14 (also known as p38alpha) in regulation of lung stem or progenitor cell proliferation and differentiation.
Kim
Carla Bender
CB
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Children's Hospital Boston Stem Cell Program, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA. Electronic address: carla.kim@childrens.harvard.edu.
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D008168:Lung / Q000166:cytology* / Q000201:enzymology; D051379:Mice; D048308:Mitogen-Activated Protein Kinase 14 / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology
D048308:Mitogen-Activated Protein Kinase 14