Polymorphism of human telomeric quadruplex structures.
Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.
Dai
Jixun
J
College of Pharmacy, The University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.
Carver
Megan
M
Yang
Danzhou
D
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D054856:G-Quadruplexes; D006801:Humans; D011110:Polymorphism, Genetic; D011188:Potassium / Q000737:chemistry / Q000378:metabolism; D016615:Telomere / Q000235:genetics*
D004247:DNA; D011188:Potassium