title: Complex riboswitches.
abstract: Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some are capable of sensory and regulatory feats that are competitive with their protein counterparts.
authors: Department of Molecular, Cellular and Developmental Biology and Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. ronald.breaker@yale.edu
authors: Ronald R
authors: RR
authors: Breaker
mesh_terms: D017398:Alternative Splicing; D052157:Aptamers, Nucleotide / Q000378:metabolism*; D001419:Bacteria / Q000235:genetics; D005658:Fungi / Q000235:genetics; D005786:Gene Expression Regulation; D007700:Kinetics; D008024:Ligands; D009690:Nucleic Acid Conformation; D010944:Plants / Q000235:genetics; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D038621:Regulatory Sequences, Ribonucleic Acid / Q000235:genetics*; D013816:Thermodynamics; D020506:Untranslated Regions / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D008024:Ligands; D012333:RNA, Messenger; D038621:Regulatory Sequences, Ribonucleic Acid; D020506:Untranslated Regions