Therapeutic decision in chronic osteomyelitis: sinus track culture versus intraoperative bone culture.
BACKGROUND
The ideal specimen for identification of the etiologic agents in chronic osteomyelitis for best antibiotic decision remains controversial.


OBJECTIVE
To assess the concordance of sinus track culture (STC) with that of intraoperative bone culture (IBC) to guide antibiotic therapy in chronic osteomyelitis.


METHODS
A prospective comparative study of chronic osteomyelitis patients seen in our centre from January 2004 to December 2006. Specimens from the depths of sinus track and intraoperative bone biopsy were obtained from each patient and subjected to microbiologic examination and their concordance determined.


RESULTS
In STCs Staphylococcus aureus has the highest sensitivity (60.5%), specificity (45.0%) and positive predictive value (72.2%). The overall sensitivity (50.9%), specificity (20%) and predictive value (47.5%) of sinus track specimens were very low. Antibiotic decision based on IBC showed 106 patients (82.8%) had resolution of chronic osteomyelitis at mean of 2 years follow-up.


CONCLUSIONS
IBC appears to predict more reliably the complete etiologic organisms than STCs in chronic osteomyelitis.
Akinyoola
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Department of Orthopaedic Surgery and Traumatology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria. aakinyoola@yahoo.co.uk
Adegbehingbe
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OO
Aboderin
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AO
D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D010019:Osteomyelitis / Q000382:microbiology*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018461:Soft Tissue Infections / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis; D055815:Young Adult