Transitioning of children with GH deficiency to adult dosing: changes in body composition.
As more evidence gathers regarding the beneficial effect of growth hormone replacement therapy (GHRT) on body composition and other parameters in adults with childhood-onset growth hormone deficiency (GHD), questions emerge regarding whether or not GHRT should be discontinued following cessation of statural growth, and the effect of GHRT during the transition period on body composition and related parameters. This review discusses the effect of discontinuation of GHRT following attainment of adult stature, and the treatment and dose effect when GHRT is reinstated. We also review data regarding who should receive GHRT, the criteria for diagnosing persistent GHD, dosing of GHRT and the possibility of a GH 'holiday'.
Nguyen
Vi Thuy
VT
Pediatric Endocrine Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, MA, 02114, USA.
Misra
Madhusmita
M
D000293:Adolescent; D000328:Adult; D001823:Body Composition / Q000187:drug effects / Q000502:physiology*; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency* / Q000494:pharmacology / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology; D008297:Male; D055815:Young Adult
D013006:Growth Hormone