title: Survival after resection of ampullary carcinoma: a national population-based study.
abstract: BACKGROUND
  Ampullary cancer is the second most common periampullary cancer, with a resection and survival rate more favorable than that for pancreatic cancer. However, most reports have been conducted at single institutions with small sample sizes, and results may not reflect the practices and outcomes in the community. Our objective was to complete a population-based analysis of patients undergoing resection for ampullary carcinoma and compare it with outcomes in the published literature.
  
  
  METHODS
  Patients diagnosed with ampullary cancer reported in the Surveillance, Epidemiology, and End Results program (1988-2003) were collected. Primary outcome was survival (5-year), and secondary outcome was stage at presentation. Comparisons were made with outcomes reported in the literature (resection rate, perioperative mortality, and 5-year survival).
  
  
  RESULTS
  Of the 3292 ampullary cancer patients, 1301 (40%) underwent resection. Thirty-seven percent presented with stage I tumors. Perioperative mortality (30 day) was 7.6% after resection, and 5-year survival was 36.8%. Few patients died if they survived at least 5 years. The cancer registry data showed less early stage disease, higher perioperative mortality, and lower 5-year survival compared with published reports.
  
  
  CONCLUSIONS
  This is the largest population-based analysis of ampullary carcinoma. Resection rates and survival at the national level are lower, in general, compared with cancer center reports, which may have implications for regionalizing these procedures. Many patients surviving at least 5 years seem to be cured by surgical resection.
authors: Department of Surgery, Geffen School of Medicine at UCLA, CHS, Rm 72-215, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.
authors: Jessica B
authors: JB
authors: O'Connell
authors: Melinda A
authors: MA
authors: Maggard
authors: Jesse
authors: J
authors: Manunga
authors: James S
authors: JS
authors: Tomlinson
authors: Howard A
authors: HA
authors: Reber
authors: Clifford Y
authors: CY
authors: Ko
authors: O Joe
authors: OJ
authors: Hines
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016577:Pancreaticoduodenectomy; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome