title: Analytical description of dose profile behaviour in Gamma Knife radiosurgery.
abstract: Stereotactic Gamma Knife radiosurgery utilizes ionizing beams from (60)Co sources and relies on a combination of collimator sizes, weighting, etc to generate a high-dose region that is conformal with a designated target volume. Dose computation is typically performed by computer, but in this paper, single collimator dose profile behaviour is modelled analytically and then extended to accommodate multiple collimators of different weights with co-located isocentres. The dose profile from a single helmet is derived from a top-hat beam profile approximation and an idealized symmetric distribution of sources is used to represent the 201 sources within a collimating helmet. The results from the analysis are validated by an independent numerical model and also compared with those obtained by other groups using numerical and experimental methods. With respect to multiple collimators, the relationship between the size (full width half maximum) of the irradiated volume and relative collimator weighting is also examined using the simple analytical model. The simplicity of the mathematics clarifies the relationship between beam profile, dose profile and multiple collimator behaviour, and provides data that compare favourably with published literature.
authors: Department of Medical Physics and Clinical Engineering, I Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK. j.w.fenner@sheffield.ac.uk
authors: J
authors: J
authors: Fenner
authors: M
authors: M
authors: Gwilliam
authors: R
authors: R
authors: Mehrem
authors: A
authors: A
authors: Bird
authors: L
authors: L
authors: Walton
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional; D015233:Models, Statistical; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D011874:Radiometry; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D013238:Stereotaxic Techniques
chemical_list: D003037:Cobalt Radioisotopes