title: Remission of infantile generalized myofibromatosis after interferon alpha therapy.
abstract: Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
authors: Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy. auriti@opbg.net
authors: Cinzia
authors: C
authors: Auriti
authors: Mark W
authors: MW
authors: Kieran
authors: Giovanni
authors: G
authors: Deb
authors: Rita
authors: R
authors: Devito
authors: Luciano
authors: L
authors: Pasquini
authors: Olivier
authors: O
authors: Danhaive
mesh_terms: D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood / Q000652:urine; D006801:Humans; D007223:Infant; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D018224:Myofibromatosis / Q000188:drug therapy*; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000652:urine
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2