title: Late circulatory dysfunction and decreased cerebral blood flow volume in infants with periventricular leukomalacia.
abstract: Periventricular leukomalacia is a major neuropathology in preterm infants associated with adverse motor and cognitive outcome. The cerebral blood flow volume of the internal carotid artery and the vertebral artery was measured by ultrasonography at the neck in 36 low-birth-weight infants with gestational age of 25-34 weeks in order to investigate the pathophysiology of cerebral white-matter injury: 30 infants, normal and 6 infants, diagnosed as PVL. The mean blood flow velocity and diameter of each vessel were measured at postnatal days from day 0 to day 70. The intravascular flow volume was determined by calculating the mean blood flow velocity and the cross-sectional area. The mean blood pressures were recorded and PaCO(2) was determined. The total blood flow volume was significantly lower in infants with PVL than in normal infants on days 0, 1, 21, 28, 35, 42, and 63. The mean blood pressure was significantly lower in infants with PVL than in normal infants on days 7, 14, 21, 28, and 42. We suggest that the total cerebral blood supply is decreased in cases of PVL in the few days after birth and from day 21 to day 42. The results of the present study suggest that a dip in the blood flow volume in the few days after birth might result in subsequent PVL.
authors: Nagoya City University, Graduate School of Medical Sciences, Department of Pediatrics, Neonatology and Congenital Disorders, Kawasumi, Mizuho, Nagoya, Aichi 467-8601, Japan. fukuda@med.nagoya-cu.ac.jp
authors: Sumio
authors: S
authors: Fukuda
authors: Keisuke
authors: K
authors: Mizuno
authors: Hiroki
authors: H
authors: Kakita
authors: Takenori
authors: T
authors: Kato
authors: Mohamed Hamed
authors: MH
authors: Hussein
authors: Tetsuya
authors: T
authors: Ito
authors: Ghada A
authors: GA
authors: Daoud
authors: Ineko
authors: I
authors: Kato
authors: Satoshi
authors: S
authors: Suzuki
authors: Hajime
authors: H
authors: Togari
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D007969:Leukomalacia, Periventricular / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D014463:Ultrasonography