title: Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population. The Fukuoka Stroke Registry and the Hisayama Study.
abstract: OBJECTIVE
  Lymphotoxin alpha (LTA), one of the tumor necrosis factor family proteins, is an important proinflammatory cytokine and appears to play a putative role in the inflammatory process of atherosclerosis. Recent genetic studies have suggested that variations in the gene encoding LTA, which affect its expression and biological function, may contribute to the development of vascular diseases. We conducted a case-control study to clarify the association of LTA gene polymorphisms with ischemic stroke in a large Japanese population.
  
  
  METHODS
  Genotyping for LTA A252G and C804A polymorphisms was achieved by a rapid-cycle polymerase chain reaction and melting curve analysis using fluorescent probes in 1,044 incident cases of ischemic stroke recruited from the Fukuoka Stroke Registry and 1,044 age- and sex-matched control subjects recruited from the Hisayama Study.
  
  
  RESULTS
  The overall distribution of allele and genotype for each polymorphism was similar between stroke patients and control subjects. The allele frequencies of 252G and 804A were slightly lower in stroke patients than in control subjects; however, conditional logistic regression analysis adjusted for potential risk factors found no association between the risk of ischemic stroke and either polymorphism. In terms of stroke subtype, we also found no association of these polymorphisms with any subtypes of ischemic stroke.
  
  
  CONCLUSIONS
  Neither the A252G nor C804A polymorphism of the LTA gene was associated with stroke overall and any subtypes of ischemic stroke in the Japanese population.
authors: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Noriko
authors: N
authors: Hagiwara
authors: Takanari
authors: T
authors: Kitazono
authors: Masahiro
authors: M
authors: Kamouchi
authors: Junya
authors: J
authors: Kuroda
authors: Tetsuro
authors: T
authors: Ago
authors: Jun
authors: J
authors: Hata
authors: Toshiharu
authors: T
authors: Ninomiya
authors: Hiroaki
authors: H
authors: Ooboshi
authors: Yasuhiro
authors: Y
authors: Kumai
authors: Sohei
authors: S
authors: Yoshimura
authors: Kinya
authors: K
authors: Tamaki
authors: Kenichiro
authors: K
authors: Fujii
authors: Tetsuhiko
authors: T
authors: Nagao
authors: Yasushi
authors: Y
authors: Okada
authors: Kazunori
authors: K
authors: Toyoda
authors: Hiroshi
authors: H
authors: Nakane
authors: Hiroshi
authors: H
authors: Sugimori
authors: Yoshichika
authors: Y
authors: Yamashita
authors: Yoshiyuki
authors: Y
authors: Wakugawa
authors: Michiaki
authors: M
authors: Kubo
authors: Yumihiro
authors: Y
authors: Tanizaki
authors: Yutaka
authors: Y
authors: Kiyohara
authors: Setsuro
authors: S
authors: Ibayashi
authors: Mitsuo
authors: M
authors: Iida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012042:Registries; D020521:Stroke / Q000208:ethnology / Q000235:genetics*
chemical_list: D008233:Lymphotoxin-alpha