Knocking the Wnt out of the sails of leukemia stem cell development.
Tumor propagation by cancer stem cells (CSCs) requires their ability to self-renew, and yet the signal pathways involved in this process remain poorly defined. In the December issue of Cancer Cell, Zhao et al. (2007) provide compelling evidence that Wnt/beta-catenin signaling is crucial for the maintenance of chronic myelogenous leukemia (CML) stem cells.
Deshpande
Aniruddha J
AJ
Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany.
Buske
Christian
C
D018450:Disease Progression; D017353:Gene Deletion; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics* / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology*
D051153:Wnt Proteins; D051176:beta Catenin