Influence of topical application of basic fibroblast growth factor upon inner ear.
BACKGROUND
Basic fibroblast growth factor (b-FGF) has recently been shown to have a positive effect on the treatment of postoperative mastoid cavity problem, but its ototoxicity has not been investigated.


OBJECTIVE
To investigate the effect of b-FGF on the inner ear of guinea pigs.


METHODS
In groups A (n = 10) and B (n =11), b-FGF was applied into the left external auditory canal and the middle ear, respectively. The right ear served as a control. At 1 week after b-FGF administration, the endocochlear DC potential (EP) was measured, and morphology of the cochleae was examined by scanning electron microscopy.


RESULTS
In group A, the EP values of experimental ears and controls were 90.0 +/- 8.4 (mV, mean +/- SD) and 89.4 +/- 4.3 (P > 0.05). In group B, the values were 86.5 +/- 11.4 and 87.5 +/- 6.1, respectively, (P > 0.05). Morphological findings showed no damage on the cochlear.


CONCLUSIONS
Application of b-FGF to the external and middle ears does not seem to have an apparent risk of ototoxicity.
Kase
Kei-Ichi
K
Department of Otolaryngology-Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. charles@icv-net.ne.jp
Iwanaga
Tetsu
T
Terakado
Mariko
M
Tanaka
Fujinobu
F
Takasaki
Kenji
K
Kumagami
Hidetaka
H
Takahashi
Haruo
H
D000287:Administration, Topical; D000818:Animals; D002452:Cell Count; D003051:Cochlea / Q000187:drug effects / Q000502:physiology; D007758:Ear, Inner / Q000187:drug effects*; D004594:Electrophysiology; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D006168:Guinea Pigs; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects; D008297:Male; D008855:Microscopy, Electron, Scanning
D016222:Fibroblast Growth Factor 2