Solving the shugoshin puzzle.
Shugoshin proteins form a complex with protein phosphatase 2A (PP2A) that protects centromeric cohesin from separase-mediated cleavage during yeast meiosis I. Recent work shows that this mechanism is conserved from yeast to mammals. Importantly, a model emerges that explains a long-standing puzzle, namely why the shugoshin-PP2A complex mediates protection of centromeric cohesin from separase cleavage specifically during meiosis I, but not during meiosis II or mitosis.
Gregan
Juraj
J
Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria. juraj.gregan@univie.ac.at
Spirek
Mario
M
Rumpf
Cornelia
C
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008540:Meiosis / Q000235:genetics / Q000502:physiology*; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D008958:Models, Molecular
D018797:Cell Cycle Proteins; C496644:SGO1 protein, human; C527733:shugoshin protein, mouse