Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53.
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
Szybka
M
M
Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93-509, Poland.
Zawlik
I
I
Kulczycka
D
D
Golanska
E
E
Jesien
E
E
Kupnicka
D
D
Stawski
R
R
Piaskowski
S
S
Bieniek
E
E
Zakrzewska
M
M
Kordek
R
R
Liberski
P P
PP
Rieske
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics*; D005260:Female; D016158:Genes, p53; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53