In vitro antibiotic susceptibility of preoperative normal conjunctival bacteria.
OBJECTIVE
To determine the antibiotic susceptibility of preoperative conjunctival bacterial flora.


METHODS
Antibiotic susceptibility of conjunctival bacterial strains isolated from 142 patients undergoing intraocular surgery was determined using the Kirby-Bauer disc diffusion technique. chi(2) statistical analysis was performed.


RESULTS
Among the 116 bacteria isolated, 95 (82%) were coagulase-negative staphylococci (CNS). Most (>75%) of them were susceptible to vancomycin, minocycline, aminoglycosides, gatifloxacin, levofloxacin, and moxifloxacin. Approximately one-half of CNS was resistant to erythromycin and azithromycin. Over 90% of streptococci were susceptible to levofloxacin, moxifloxacin, and gatifloxacin.


RESULTS
Fluoroquinolones, specifically gatifloxacin, levofloxacin, and moxifloxacin continue to provide broad-spectrum coverage against common conjunctival bacterial flora.
Ta
C N
CN
Department of Ophthalmology, School of Medicine, Stanford University, Stanford, CA 94305, USA. cta@ stanford.edu
He
L
L
Mino de Kaspar
H
H
D000869:Anterior Eye Segment / Q000601:surgery*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D003228:Conjunctiva / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D015818:Eye Infections, Bacterial / Q000382:microbiology; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones