title: Antidiabetic properties of aqueous barks extract of Parinari excelsa in alloxan-induced diabetic rats.
abstract: The aqueous extract of the Parinari excelsa barks at doses of 100 and 300 mg/kg/day for 7 days has a significant antihyperglycemic effect on alloxan-induced diabetic rats. At the same dose the acute oral administration of aqueous extract of the P. excelsa barks (100 and 300 mg/kg) induced a significant decrease of blood glucose on glucose-loaded normoglycaemic rats. Our results seem to confirm the rational bases for its use in traditional medicine.
authors: Laboratoire de Pharmacologie, Faculté de Médecine, de Pharmacie et d'Odontostomatologie, Université Cheikh Anta Diop, Dakar, Senegal. mndiaye10@sentoo.sn
authors: M
authors: M
authors: Ndiaye
authors: W
authors: W
authors: Diatta
authors: A N
authors: AN
authors: Sy
authors: A M
authors: AM
authors: Dièye
authors: B
authors: B
authors: Faye
authors: E
authors: E
authors: Bassène
mesh_terms: D000496:Alloxan; D000818:Animals; D045469:Chrysobalanaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D005905:Glyburide