[Neuroimmune parameters as markers of therapeutic and rehabilitation efficacy in children with organic mental retardation].
A complex of therapeutic and rehabilitation measures including neurometabolics (brain cytomedine cortexin, pantogam and glycine), antioxidants and vascular medications, massage, physiotherapeutic procedures and special psychological and educational correction was administered to 40 children, aged 5-8 years, with organic mental retardation. A control group consisted of age-matched healthy children. The efficacy of rehabilitation was assessed after 3 months basing on a special coefficient and correlations between this coefficient and some neuroimmune parameters. This approach makes it possible to specify favorable prognostic markers, i.e. the decrease of serum level of neuron-specific enolase, myelin-associated glycoprotein antibodies and increase of brain-derived neurotrophic factor.
Govorin
N V
NV
Zlova
T P
TP
Akhmetova
V V
VV
D000906:Antibodies / Q000276:immunology; D001921:Brain / Q000276:immunology*; D019208:Brain-Derived Neurotrophic Factor / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D019965:Neurocognitive Disorders / Q000150:complications / Q000276:immunology / Q000628:therapy; D010455:Peptides / Q000627:therapeutic use*; D026741:Physical Therapy Modalities; D024505:Tocopherols / Q000627:therapeutic use*; D016896:Treatment Outcome; D014815:Vitamins / Q000627:therapeutic use*
D000906:Antibodies; D019208:Brain-Derived Neurotrophic Factor; D036341:Intercellular Signaling Peptides and Proteins; D018992:Myelin-Associated Glycoprotein; D010455:Peptides; D014815:Vitamins; C056590:cortexin; D024505:Tocopherols