title: [A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia].
abstract: Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine.
authors: Korea University Medical College Guro Hospital, Department of Internal Medicine, Seoul, Korea.
authors: Ji Yeon
authors: JY
authors: Lee
authors: Eun Bum
authors: EB
authors: Park
authors: Jae Hong
authors: JH
authors: Ahn
authors: Sang-jun
authors: SJ
authors: Suh
authors: Young Kul
authors: YK
authors: Jung
authors: Ji Hoon
authors: JH
authors: Kim
authors: Bong Kyung
authors: BK
authors: Shin
authors: Jin Hyuk
authors: JH
authors: Yang
authors: Jong Eun
authors: JE
authors: Yeon
authors: Kwan Soo
authors: KS
authors: Byun
mesh_terms: D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013988:Ticlopidine / Q000009:adverse effects*
chemical_list: D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine