title: Cardiac dysfunction after burns.
abstract: OBJECTIVE
  Using transoesophageal echocardiography (TEE) we investigated the occurrence, and the association of possible abnormalities of motion of the regional wall of the heart (WMA) or diastolic dysfunction with raised troponin concentrations, or both during fluid resuscitation in patients with severe burns.
  
  
  METHODS
  Ten consecutive adults (aged 36-89 years, two women) with burns exceeding 20% total burned body surface area who needed mechanical ventilation were studied. Their mean Baux index was 92.7, and they were resuscitated according to the Parkland formula. Thirty series of TEE examinations and simultaneous laboratory tests for myocyte damage were done 12, 24, and 36h after the burn.
  
  
  RESULTS
  Half (n=5) the patients had varying grades of leakage of the marker that correlated with changeable WMA at 12, 24 and 36h after the burn (p< or =0.001, 0.044 and 0.02, respectively). No patient had WMA and normal concentrations of biomarkers or vice versa. The mitral deceleration time was short, but left ventricular filling velocity increased together with stroke volume.
  
  
  CONCLUSIONS
  Acute myocardial damage recorded by both echocardiography and leakage of troponin was common, and there was a close correlation between them. This is true also when global systolic function is not deteriorated. The mitral flow Doppler pattern suggested restrictive left ventricular diastolic function.
authors: Department of Anesthesia and Intensive Care, Linköping University Hospital, Sweden. zoltan.bak@lio.se
authors: Z
authors: Z
authors: Bak
authors: F
authors: F
authors: Sjöberg
authors: O
authors: O
authors: Eriksson
authors: I
authors: I
authors: Steinvall
authors: B
authors: B
authors: Janerot-Sjoberg
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D017548:Echocardiography, Transesophageal; D005260:Female; D005440:Fluid Therapy; D006335:Heart Injuries / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015599:Trauma Severity Indices; D014336:Troponin / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D014336:Troponin