A virtual look at Epstein-Barr virus infection: simulation mechanism.
Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
Shapiro
M
M
Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
Duca
K A
KA
Lee
K
K
Delgado-Eckert
E
E
Hawkins
J
J
Jarrah
A S
AS
Laubenbacher
R
R
Polys
N F
NF
Hadinoto
V
V
Thorley-Lawson
D A
DA
D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D049109:Cell Proliferation; D003198:Computer Simulation; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008221:Lymphoid Tissue / Q000382:microbiology; D018448:Models, Immunological; D017735:Virus Latency