Metabolic Syndrome and its Associated Risk Factors in Healthy Adults: APopulation-Based Study in Iran.
BACKGROUND
Metabolic syndrome includes obesity, hypertriglyceridemia, glucose intolerance, hypertension, and lipid profile abnormalities. The risk of cardiovascular diseases with this syndrome is higher than with each of its components alone. Currently, cardiovascular disorders have a great burden and a high mortality rate in Iran. This study was performed to determine prevalence of the metabolic syndrome and its underlying components in an urban population of Tehran.


METHODS
The 25-64-year-old individuals in the Population Laboratory of Tehran University of Medical Sciences were studied through a single-stage cluster sampling; 1573 participants were studied. The response rate was 94.08%. The study was designed according to the World Health Organization (WHO) MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) project using the Adult Treatment Panel III (ATPIII) criteria. The parameters used for the risk analysis were waist circumference, fasting serum triglycerides, high density lipoprotein (HDL)-cholesterol, blood pressure, and fasting plasma glucose.


RESULTS
The crude prevalence rate of the metabolic syndrome was 29.9% (age-adjusted: 27.5%). The prevalence was significantly higher in women than in men (35.9% vs. 20.3%). The prevalence increased with age in both genders. In the whole population, 88% met at least one of the metabolic syndrome criteria. The most prevalent metabolic abnormalities were hypertriglyceridemia and hypertension that were present in more than half of the population. Also, means of HDL was significantly higher in metabolic syndrome positive group. By further adjustment for age and sex in multivariate analysis, the difference disappeared and even HDL-C level was slightly lower in people with metabolic syndrome.


CONCLUSIONS
RESULTS demonstrate high metabolic syndrome rate among target population especially in women. In view of correlation between metabolic syndrome and cardiovascular disease, it must be the priority for interventional preventive measures.
Fakhrzadeh
Hossein
H
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ebrahimpour
Pantea
P
Pourebrahim
Rasoul
R
Heshmat
Ramin
R
Larijani
Bagher
B