[Effect of indoleamine 2,3-dioxygenase on transplantation immunity].
OBJECTIVE
To review the research progress of possible mechanism of indoleamine 2, 3-dioxygenase (IDO) in immunological regulation and function of transplantation immunity.


METHODS
The advances in the IDO location, immunological regulatory mechanism and function of transplantation immunity were introduced based on the recent related literature.


RESULTS
IDO played an immunoregulatory role by locally depleting tryptophan in tissue microenvironment which resulted in immunosuppression of allogeneic T-cell proliferation. IDO cDNA was delivered to chromosome in interesting cells by gene transfection and stimulated to express, which was associated with a prolongation in allograft survival in vivo.


CONCLUSIONS
IDO offers a new way in transplantation immunity, and this provid novel method for elevating allograft survival rate.
Duan
Xiaohong
X
Department of Otolaryngology, Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi, 710038, P.R. China.
Cui
Pengcheng
P
Jiang
Xun
X
D000818:Animals; D006801:Humans; D007165:Immunosuppression Therapy; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D016377:Organ Transplantation; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014162:Transfection; D014181:Transplantation Immunology / Q000502:physiology*; D023001:Transplantation Tolerance / Q000502:physiology; D014364:Tryptophan / Q000378:metabolism*
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D014364:Tryptophan