Inulin supplementation prevents high fructose diet-induced hypertension in rats.
OBJECTIVE
The aim of this experiment was to evaluate the potential beneficial effect of supplementation with different inulin-type fructan fractions against common features of the metabolic syndrome in a rat model of this syndrome (fructose-fed rat).


METHODS
Forty Wistar rats were randomly divided into five groups and the animals received for 4 weeks either a semi-purified starch or fructose-based diet, or diets in which fructose was partially substituted with various fructans: 10 g/100 g of long-chain inulin or oligofructose, or an oligofructose-enriched inulin. After this period, blood pressure was measured and samples of blood and tissues were collected for selected biochemical analyses.


RESULTS
As compared to the starch-fed group, the fructose-fed rats presented: hypertriglyceridemia, hypertension, increased susceptibility to heart peroxidation and renal damages. Long-chain inulin and oligofructose-enriched inulin supplementation prevented fructose induced elevated blood pressure, susceptibility to heart peroxidation and renal damages. All inulin-type fructans containing diets prevented fructose induced hypertriglyceridemia.


CONCLUSIONS
These results suggest that supplementation with inulin-type fructans is efficient against fructose induced hypertension and that effects are most pronounced for long-chain inulin and oligofructose-enriched inulin. We hypothesize that the anti-hypertensive effect of inulin could be explained by the reduction of the high fructose induced oxidative stress.
Rault-Nania
Marie-Hélène
MH
INRA, Clermont Ferrand/Theix, Centre de Recherche en Nutrition Humaine d'Auvergne, Unité de Nutrition Humaine, Equipe Stress Métabolique et Micronutriments, Saint-Genès-Champanelle, France.
Demougeot
Céline
C
Gueux
Elyett
E
Berthelot
Alain
A
Dzimira
Stanislaw
S
Rayssiguier
Yves
Y
Rock
Edmond
E
Mazur
Andrzej
A
D000818:Animals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005630:Fructans / Q000737:chemistry / Q000494:pharmacology*; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D007444:Inulin / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013213:Starch
D005630:Fructans; D009844:Oligosaccharides; C120489:oligofructose; D005632:Fructose; D013213:Starch; D007444:Inulin