title: Design and synthesis of C6-C8 bridged epothilone A.
abstract: A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 microM) against the A2780 human ovarian cancer cell line.
authors: Department of Chemistry, Emory University, Atlanta, GA 30322, USA.
authors: Weiqiang
authors: W
authors: Zhan
authors: Yi
authors: Y
authors: Jiang
authors: Peggy J
authors: PJ
authors: Brodie
authors: David G I
authors: DG
authors: Kingston
authors: Dennis C
authors: DC
authors: Liotta
authors: James P
authors: JP
authors: Snyder
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008958:Models, Molecular
chemical_list: D034261:Epothilones; C093787:epothilone A