Karyotyping twins in early pregnancy loss: a novel approach of obtaining specimens to avoid maternal contamination.
OBJECTIVE
To test for chromosomal abnormalities in a missed abortion involving a twin gestation.


METHODS
Case report.


METHODS
University-based infertility practice.


METHODS
A 37-year-old G3P0030 with recurrent abortions presented with a fourth missed abortion involving a twin gestation in the first trimester.


METHODS
Under anesthesia, hysteroscopy was performed and specimens obtained for karyotyping from each twin.


METHODS
Karyotype of each twin.


RESULTS
The karyotype of the conceptus on the left was 46,XY and that on the right was 46,XX.


CONCLUSIONS
Direct hysteroscopic biopsies can successfully differentiate the karyotypes of each twin of a missed abortion.
Awonuga
Awoniyi O
AO
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, Michigan 48201, USA. niyiawonuga@aol.com
Abdallah
Mazen E
ME
Puscheck
Elizabeth E
EE
D000026:Abortion, Habitual / Q000235:genetics*; D000030:Abortion, Missed / Q000235:genetics*; D000328:Adult; D001706:Biopsy; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D005865:Gestational Age; D006801:Humans; D015907:Hysteroscopy; D007621:Karyotyping; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000235:genetics*; D013048:Specimen Handling / Q000379:methods*; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins / Q000235:genetics*