Association of MYO9B haplotype with type 1 diabetes.
MYO9B (myosin IXB) polymorphisms were associated with celiac disease and ulcerative colitis susceptibility, presumably through alteration of the intestinal permeability. Recently this gene was also associated with several diseases with an autoimmune component, such as rheumatoid arthritis and systemic lupus erythematosus. We aimed to test, for the first time, the potential role of MYO9B polymorphisms in type 1 diabetes (T1D), an autoimmune condition preceded by changes in intestinal barrier integrity. Three previously associated MYO9B polymorphisms (rs962917, rs2279003, and rs2305764) were studied in 316 T1D patients and 706 ethnically matched controls. Minor alleles of those polymorphisms were more frequent in diabetic patients than in controls and the haplotype carrying major alleles in those positions, rs962917*G/rs2279003*C/rs2305764*G, significantly reduced the risk of T1D in the Spanish population (p = 0.004; OR [95% confidence interval] = 0.68 [0.52-0.90]). Our data suggest an involvement of this MYO9B chromosomal region in T1D predisposition, indicating extensive influence on autoimmune diseases.
Santiago
Jose Luis
JL
Immunology Department, Hospital Universitario San Carlos, Madrid, Spain.
Martínez
Alfonso
A
Núñez
Concepción
C
de la Calle
Hermenegildo
H
Fernández-Arquero
Miguel
M
de la Concha
Emilio G
EG
Urcelay
E
E
D001327:Autoimmune Diseases / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009218:Myosins / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013030:Spain
D006680:HLA Antigens; C113469:myosin IXB; D009218:Myosins