title: Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole.
abstract: We demonstrate that incorporation of MnSalen into a protein scaffold enhances the chemoselectivity in sulfoxidation of thioanisole and find that both the polarity and hydrogen bonding of the protein scaffold play an important role in tuning the chemoselectivity.
authors: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors: Jun-Long
authors: JL
authors: Zhang
authors: Dewain K
authors: DK
authors: Garner
authors: Lei
authors: L
authors: Liang
authors: Qian
authors: Q
authors: Chen
authors: Yi
authors: Y
authors: Lu
mesh_terms: D002614:Chelating Agents / Q000737:chemistry; D003067:Coenzymes / Q000737:chemistry*; D003198:Computer Simulation; D005029:Ethylenediamines / Q000737:chemistry; D006860:Hydrogen Bonding; D008345:Manganese / Q000737:chemistry*; D045726:Metalloproteases / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015202:Protein Engineering; D013379:Substrate Specificity; D013440:Sulfides / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D003067:Coenzymes; D005029:Ethylenediamines; D009942:Organometallic Compounds; D013440:Sulfides; D013454:Sulfoxides; D008345:Manganese; C011452:disalicylaldehyde ethylenediamine; C093850:methylphenylsulfide; D045726:Metalloproteases