title: Hepatocyte growth factor gene therapy for hypertension.
abstract: Hepatocyte growth factor (HGF) has mitogenic, motogenic, and morphogenic biological activities as well as helps in regenerating various tissues. In cardiovascular organs, HGF was reported to have anti-apoptotic, anti-fibrotic, and vasodilating effects. HGF has close relationships with hypertension, arteriosclerosis, and heart failure. HGF enhances renal regeneration and suppresses the progression of hypertension. Intramuscular electroporation of the therapeutic gene is a simple, economic, and low toxic method compared with systemic administration of the purified proteins or peptides. We outline the technique of intramuscular electroporation of HGF gene as a remedy for hypertension.
authors: Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan.
authors: Kazuo
authors: K
authors: Komamura
authors: Jun-Ichi
authors: J
authors: Miyazaki
authors: Enyu
authors: E
authors: Imai
authors: Kunio
authors: K
authors: Matsumoto
authors: Toshikazu
authors: T
authors: Nakamura
authors: Masatsugu
authors: M
authors: Hori
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy; D004274:DNA, Recombinant / Q000008:administration & dosage / Q000235:genetics; D053672:Electrochemotherapy / Q000379:methods*; D015870:Gene Expression; D015316:Genetic Therapy / Q000379:methods*; D017228:Hepatocyte Growth Factor / Q000097:blood / Q000235:genetics* / Q000502:physiology; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D007273:Injections, Intramuscular; D015848:Interleukin-5 / Q000235:genetics; D007763:Lac Operon; D008297:Male; D010957:Plasmids / Q000008:administration & dosage / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D001616:beta-Galactosidase / Q000235:genetics
chemical_list: D004274:DNA, Recombinant; D015848:Interleukin-5; D017228:Hepatocyte Growth Factor; D001616:beta-Galactosidase