title: Atypical ocular presentations of Rosai-Dorfman disease.
abstract: OBJECTIVE
  To report atypical ocular findings of Rosai-Dorfman disease and to determine association with parvovirus 19.
  
  
  METHODS
  The study is an observational case series of three patients that had atypical ocular presentations of Rosai-Dorfman disease.
  
  
  METHODS
  A multicenter, retrospective case series of 3 patients was evaluated for varied ocular complaints, including enlarging epibulbar masses and uveitis. Histologic specimens were examined retrospectively for parvovirus 19 antigen.
  
  
  RESULTS
  Patients presented with ocular findings prior to or concurrently with systemic findings, with and without associated lymphadenopathy. Two cases presented with epibulbar masses, one with the mass as the only sign of disease while the other exhibited multinodal involvement with bilateral epibulbar masses and anterior granulomatous inflammation. Parvovirus B19 antibody staining was negative in these cases. The final case exhibited bilateral anterior granulomatous inflammation and choroidal infiltrates.
  
  
  CONCLUSIONS
  Ocular findings may be the sole or presenting complaint in Rosai-Dorfman disease prior to recognition of systemic disease and should be considered in the differential diagnosis of epibulbar masses as well as anterior and posterior granulomatous inflammation.
authors: Long Island Eye Surgical Care, P.C., Port Jefferson Station, New York, USA.
authors: Raju
authors: R
authors: Sarwal
authors: Elmer
authors: E
authors: Tu
authors: Frank I
authors: FI
authors: Mendelblatt
authors: Joel
authors: J
authors: Sugar
authors: Steven A
authors: SA
authors: Gross
authors: Jose S
authors: JS
authors: Pulido
authors: Deepak P
authors: DP
authors: Edward
mesh_terms: D000956:Antigens, Viral / Q000032:analysis*; D005128:Eye Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000821:virology; D005260:Female; D006099:Granuloma / Q000209:etiology; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007249:Inflammation / Q000209:etiology; D008875:Middle Aged; D016732:Parvovirus B19, Human / Q000276:immunology; D012189:Retrospective Studies
chemical_list: D000956:Antigens, Viral