title: Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population.
abstract: BACKGROUND
  Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity.
  
  
  OBJECTIVE
  We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population.
  
  
  METHODS
  The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis.
  
  
  RESULTS
  There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01-2.52, <0.05).
  
  
  CONCLUSIONS
  The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.
authors: Department of Gastroenterology, Fujita Health University School of Medicine, Aichi Prefecture, 470-1192, Japan.
authors: Fang-Yu
authors: FY
authors: Wang
authors: Tomomitsu
authors: T
authors: Tahara
authors: Tomiyasu
authors: T
authors: Arisawa
authors: Tomoyuki
authors: T
authors: Shibata
authors: Hiromi
authors: H
authors: Yamashita
authors: Masakatsu
authors: M
authors: Nakamura
authors: Daisuke
authors: D
authors: Yoshioka
authors: Masaaki
authors: M
authors: Okubo
authors: Naoko
authors: N
authors: Maruyama
authors: Toshiaki
authors: T
authors: Kamano
authors: Yoshio
authors: Y
authors: Kamiya
authors: Masahiko
authors: M
authors: Nakamura
authors: Hiroshi
authors: H
authors: Fujita
authors: Mitsuo
authors: M
authors: Nagasaka
authors: Masami
authors: M
authors: Iwata
authors: Kazuya
authors: K
authors: Takahama
authors: Makoto
authors: M
authors: Watanabe
authors: Hiroshi
authors: H
authors: Nakano
authors: Ichiro
authors: I
authors: Hirata
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000235:genetics*; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin