title: Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation.
abstract: Isolated primary granulocytic sarcoma is a rare disease that presents as an extramedullary tumor of myeloid lineage cells. Most patients subsequently develop acute myelogenous leukemia (AML) within a short period, and their prognosis is poor. Herein, we report the case of a 33-year-old woman with a primary isolated granulocytic sarcoma which originated in the small intestine. After she recovered from surgery, she received intensive chemotherapy equivalent to that for AML, followed by allogeneic bone marrow transplantation from an HLA-matched, unrelated donor. Four years after the transplantation, she remains in complete remission without graft-versus-host disease or any other symptoms. This case illustrates the effectiveness of our therapeutic strategy for isolated granulocytic sarcoma, not only with surgical resection of the tumor and intensive chemotherapy equivalent to that for AML, but also with allogeneic bone marrow transplantation, performed while no sign of AML is observed.
authors: Department of Hematology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors: Yukiko
authors: Y
authors: Kitagawa
authors: Department of Hematology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors: Yuichi
authors: Y
authors: Sameshima
authors: Department of Hematology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors: Hiroko
authors: H
authors: Shiozaki
authors: Second Department of Surgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Shinpei
authors: S
authors: Ogawa
authors: Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Akihiro
authors: A
authors: Masuda
authors: Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan.
authors: Shin-Ichiro
authors: SI
authors: Mori
authors: Department of Hematology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors: Masanao
authors: M
authors: Teramura
authors: Department of Hematology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors: Michihiko
authors: M
authors: Masuda
authors: Second Department of Surgery, Tokyo Women's Medical University, Tokyo, Japan.
authors: Shingo
authors: S
authors: Kameoka
authors: Department of Hematology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. motoji@dh.twmu.ac.jp.
authors: Toshiko
authors: T
authors: Motoji
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D007421:Intestine, Small / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents