The selectivity of autophagy and its role in cell death and survival.
Autophagy is a cellular process whose primary function is to degrade long-lived proteins and recycle cellular components. Beside macroautophagy, there are several forms of selective autophagy, including chaperone-mediated autophagy (CMA), cytoplasm to vacuole targeting (Cvt), pexophagy and mitophagy. In this review, we summarize what is currently known about selective autophagy, and discuss its role in cell death and survival. We also discuss possible mechanisms underlying the selectivity of macroautophagy.
Yu
Li
L
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-1892, USA.
Strandberg
Lindsey
L
Lenardo
Michael J
MJ
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D005057:Eukaryotic Cells / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000378:metabolism
D011506:Proteins