Maximum entropy approach for deducing amino Acid interactions in proteins.
We present a maximum entropy approach for inferring amino acid interactions in proteins subject to constraints pertaining to the mean numbers of various types of equilibrium contacts for a given sequence or a set of sequences. We have carried out several kinds of tests for a two-dimensional lattice model with just two types of amino acids with very promising results. We also show that the method works very well even when the mean numbers of contacts are not known and therefore can be applied to real proteins.
Seno
Flavio
F
INFN and Dipartimento di Fisica, Università di Padova, Via Marzolo 8, I-35131 Padova, Italy.
Trovato
Antonio
A
Banavar
Jayanth R
JR
Maritan
Amos
A
D000596:Amino Acids / Q000737:chemistry*; D019277:Entropy; D008956:Models, Chemical; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D000596:Amino Acids; D011506:Proteins