To what extent should we lower HbA1c in diabetic subjects?
Current recommendations regarding glycemic control suggest that HbA(1c) should be lower than 6.5%. This is supported by data regarding microvascular disease, namely retinopathy rather than nephropathy. The question is not completely solved regarding cardiovascular diseases, where a strategy of very low HbA(1c) ("the lower the better") is expected to be effective. Some ongoing studies will help to answer these unsolved questions.
Hadjadj
S
S
CHU de Poitiers, Department of Endocrinology Diabetology, 2, rue de la Milètrie, BP 577, 86021 Poitiers cedex, France. s.hadjadj@chu-poitiers.fr
Saulnier
P-J
PJ
Torremocha
F
F
Labbé
L
L
Maréchaud
R
R
D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008833:Microcirculation / Q000473:pathology; D012016:Reference Values
D001786:Blood Glucose; D006442:Glycated Hemoglobin