title: Early changes in renal hemodynamics in children with diabetes: Doppler sonographic findings.
abstract: OBJECTIVE
  Although clinically evident diabetes-related microvascular complications are extremely rare in childhood, early functional and structural abnormalities may be present a few years after the onset of the disease. Renal Doppler resistance index (RI) is widely used for the evaluation of blood flow in renal parenchymal diseases. This study was designed to investigate the possible alteration of intrarenal Doppler RI in children with diabetes compared with healthy children.
  
  
  METHODS
  The study was performed in 42 children with diabetes (age range, 6-18 years) and in 41 age-matched healthy controls, all having normal renal function. RI was measured with Doppler sonography in interlobular renal arteries.
  
  
  RESULTS
  RI values were significantly greater in children with diabetes than in age-matched healthy controls (0.64 +/- 0.03 versus 0.60 +/- 0.04, P < 0.035). RI correlated positively with HbA1c (P < 0.001, r = 0.42) and diabetes duration (P < 0.05, r = 0.39).
  
  
  CONCLUSIONS
  Early changes in renal hemodynamics are detectable on Doppler sonography in children with diabetes without any evidence of renal dysfunction and may suggest a preclinical stage of diabetic nephropathy.
authors: Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, 66013 Chieti, Italy.
authors: Piernicola
authors: P
authors: Pelliccia
authors: Alessandra
authors: A
authors: Savino
authors: Cristina
authors: C
authors: Cecamore
authors: Alessandra
authors: A
authors: Primavera
authors: Cosima
authors: C
authors: Schiavone
authors: Francesco
authors: F
authors: Chiarelli
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000000981:diagnostic imaging*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008297:Male; D018709:Statistics, Nonparametric; D018608:Ultrasonography, Doppler / Q000379:methods*