Efficient gene transfection with functionalised multicalixarenes.
Novel amino-functionalised multicalixarenes have been synthesised which show low cellular toxicity, effective DNA binding and, when featuring aliphatic amines, are efficient gene transfection agents.
Lalor
Ruth
R
School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK.
DiGesso
Jessica L
JL
Mueller
Anja
A
Matthews
Susan E
SE
D000588:Amines / Q000737:chemistry; D000818:Animals; D016466:CHO Cells; D047250:Calixarenes / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D050091:Dendrimers; D004591:Electrophoresis, Polyacrylamide Gel; D049452:Green Fluorescent Proteins / Q000235:genetics; D006801:Humans; D007202:Indicators and Reagents; D009000:Monocytes / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D014162:Transfection / Q000379:methods*
D000588:Amines; D050091:Dendrimers; D007202:Indicators and Reagents; D047250:Calixarenes; D049452:Green Fluorescent Proteins; D004247:DNA