Alcohol and lipid metabolism.
Many new mechanisms for alcoholic steatosis have been suggested by work reported in the last five years. These include alterations of transcriptional controls of lipid metabolism, better understanding of the effects of abnormal methionine metabolism on the endoplasmic reticulum stress response, unraveling of the basis for sensitization of the Kupffer cell to lipopolysaccharide, a better understanding of the role of cytokines and adipokines in alcoholic liver disease, and implication of the innate immune and complement systems in responses to alcohol. Much of this work has been facilitated by work with knockout mice. Undoubtedly, there are interrelationships among these various pathogenic mechanisms that ultimately will provide a more cohesive picture of how heavy alcohol use deranges hepatic lipid metabolism.
Sozio
Margaret
M
Indiana University School of Medicine, 545 Barnhill Dr., Indianapolis, IN 46202, USA.
Crabb
David W
DW
D000428:Alcohol Drinking / Q000378:metabolism*; D020751:Alcohol-Induced Disorders / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D014158:Transcription, Genetic
D005227:Fatty Acids