title: Angiotensin II regulates cardiac hypertrophy via oxidative stress but not antioxidant enzyme activities in experimental renovascular hypertension.
abstract: The aim of this study was to provide new insights into the role of angiotensin II and arterial pressure in the regulation of antioxidant enzyme activities in a renovascular model of cardiac hypertrophy. For this purpose, aortic coarcted rats were treated with losartan or minoxidil for 7 days. Angiotensin II induced cardiac hypertrophy and oxidative stress via Nox4, p22(phox) and p47(phox), which are components of the NAD(P)H oxidase. Antioxidant enzymes were regulated by arterial pressure and were not implicated in cardiac hypertrophy. Heme oxygenase-1, the rate-limiting enzyme in heme catabolism, behaved as a catalase and glutathione peroxidase, and is regulated by arterial pressure. In summary, the present report indicates that cardiac hypertrophy, induced by renovascular hypertension, depends on angiotensin II through reactive oxygen species and is not prevented by the action of antioxidant enzymes.
authors: Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
authors: Ariel H
authors: AH
authors: Polizio
authors: Karina B
authors: KB
authors: Balestrasse
authors: Gustavo G
authors: GG
authors: Yannarelli
authors: Guillermo O
authors: GO
authors: Noriega
authors: Susana
authors: S
authors: Gorzalczany
authors: Carlos
authors: C
authors: Taira
authors: Maria L
authors: ML
authors: Tomaro
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly / Q000209:etiology*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000032:analysis; D006978:Hypertension, Renovascular / Q000150:complications* / Q000378:metabolism; D019808:Losartan / Q000494:pharmacology; D008297:Male; D019255:NADPH Oxidases / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000804:Angiotensin II; D002374:Catalase; D013482:Superoxide Dismutase; D019255:NADPH Oxidases; D005978:Glutathione; D019808:Losartan