title: Gastric schwannomas: radiological features with endoscopic and pathological correlation.
abstract: OBJECTIVE
  To describe the radiological, endoscopic, and pathological findings of gastric schwannomas in 16 patients.
  
  
  METHODS
  The radiological, endoscopic, and pathological findings of 16 surgically proven cases of gastric schwannoma were retrospectively reviewed. All patients underwent computed tomography (CT) and four patients were evaluated with upper gastrointestinal series. Two radiologists reviewed the CT and upper gastrointestinal series images by consensus with regard to tumour size, contour, margin, and growth pattern, the presence or absence of ulcer, cystic change, and the CT enhancement pattern. Endoscopy was performed in eight of these 16 patients. Six patients underwent endoscopic ultrasonography. Pathological specimens were obtained from and reviewed in all 16 patients. Immunohistochemistry was performed for c-kit, CD34, smooth muscle actin, and S-100 protein.
  
  
  RESULTS
  On radiographic examination, gastric schwannomas appeared as submucosal tumours with the CT features of well-demarcated, homogeneous, and uncommonly ulcerated masses. Endoscopy with endoscopic ultrasonography demonstrated homogeneous, submucosal masses contiguous with the muscularis propria in all six examined cases. On pathological examination, gastric schwannomas appeared as well-circumscribed and homogeneous tumours in the muscularis propria and consisted microscopically of interlacing bundles of spindle cells. Strong positivity for S-100 protein was demonstrated in all 16 cases on immunohistochemistry.
  
  
  CONCLUSIONS
  Gastric schwannomas appear as submucosal tumours of the stomach and have well-demarcated and homogeneous features on CT, endoscopic ultrasonography, and gross pathology. Immunohistochemistry consistently reveals positivity for S-100 protein in the tumours.
authors: Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seodaemoon-gu, Seoul, Korea.
authors: H S
authors: HS
authors: Hong
authors: H K
authors: HK
authors: Ha
authors: H J
authors: HJ
authors: Won
authors: J H
authors: JH
authors: Byun
authors: Y M
authors: YM
authors: Shin
authors: A Y
authors: AY
authors: Kim
authors: P N
authors: PN
authors: Kim
authors: M-G
authors: MG
authors: Lee
authors: G H
authors: GH
authors: Lee
authors: M J
authors: MJ
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D019160:Endosonography; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods