title: Outcome of 234 pregnancies in 140 renal transplant recipients from five middle eastern countries.
abstract: OBJECTIVE
  To study the pregnancy and offspring outcomes in postrenal transplant recipients.
  
  
  METHODS
  This is a retrospective case-note review study investigating the outcome of 234 pregnancies in 140 renal transplant recipients from five different Middle Eastern countries.
  
  
  RESULTS
  Of the overall pregnancies 74.4% were successful albeit with high prevalences of preterm and Caesarean deliveries (40.8% and 53%, respectively). The mean serum creatinine did not rise significantly during pregnancy in the group as a whole but did so in patients who had serum creatinine of or above 150 micromol/L at the beginning of their pregnancies. The mean birth weight was (2,458 g) with 41.3% of the newborns being of low birth weight (<2,500 g). The prevalences of stillbirths were 7.3% and of spontaneous abortion was 19.3%. Preeclampsia and gestational diabetes were observed in 26.1% and 2% of pregnancies, respectively.
  
  
  CONCLUSIONS
  In the presence of good allograft function, the majority of pregnancies in renal transplant recipients have a good outcome but with increased incidence of preeclampsia, reduced gestational age, and low birth weights. Patients with baseline serum creatinine of above 150 micromol/L have an increased risk of allograft dysfunction resulting from the pregnancy.
authors: Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
authors: Huda
authors: H
authors: Al Duraihimh
authors: Ghormullah
authors: G
authors: Ghamdi
authors: Dujana
authors: D
authors: Moussa
authors: Faissal
authors: F
authors: Shaheen
authors: Nabil
authors: N
authors: Mohsen
authors: Usha
authors: U
authors: Sharma
authors: Antoine
authors: A
authors: Stephan
authors: Adnan
authors: A
authors: Alfie
authors: Mohamed
authors: M
authors: Alamin
authors: Mehmet
authors: M
authors: Haberal
authors: Bassam
authors: B
authors: Saeed
authors: Mohamed
authors: M
authors: Kechrid
authors: Abdulla
authors: A
authors: Al-Sayyari
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D002585:Cesarean Section / Q000706:statistics & numerical data; D003404:Creatinine / Q000097:blood; D005260:Female; D005865:Gestational Age; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D008877:Middle East; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D050497:Stillbirth / Q000453:epidemiology
chemical_list: D003404:Creatinine