Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons.
We have developed a new biosensor architecture, which is comprised of a polypeptide-peptide nucleic acid tri-block copolymer and which we have termed chimeric peptide beacons (CPB), that generates an optical output via a mechanism analogous to that employed in DNA-based molecular beacons.
Oh
Kenneth J
KJ
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. oh@chem.ucsb.edu
Cash
Kevin J
KJ
Lubin
Arica A
AA
Plaxco
Kevin W
KW
D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000276:immunology; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000276:immunology
D015483:HIV Antibodies; D015488:HIV Antigens; D007202:Indicators and Reagents; D020135:Peptide Nucleic Acids; D010455:Peptides; D054301:gag Gene Products, Human Immunodeficiency Virus; C054858:p17 protein, Human Immunodeficiency Virus Type 1; D004247:DNA