title: Antiplatelet drug nonresponsiveness.
abstract: The response to most medication, including antiplatelet drugs, is highly variable between individuals. Observational studies have shown that nonresponders to antiplatelet agents appear to have an increased incidence of vascular events. This review article reviews the background, mechanisms, and evidence in support of the clinical significance of this phenomenon.
authors: Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand. PatrickG@adhb.gov.nz
authors: Patrick
authors: P
authors: Gladding
authors: Mark
authors: M
authors: Webster
authors: John
authors: J
authors: Ormiston
authors: Sarah
authors: S
authors: Olsen
authors: Harvey
authors: H
authors: White
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D003327:Coronary Disease / Q000188:drug therapy; D004351:Drug Resistance; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D010979:Platelet Function Tests; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin