Serum levels of interleukin-6, tumor necrosis factor-alpha and interferon-gamma in infants with and without dengue.
This study compared the serum levels of IL-6, TNF-alpha and IFN-gamma, in children under 1 year of age with and without dengue. Sera were collected from a total of 41 children living in the Department of Antioquia, Colombia (27 patients with dengue and 14 controls). The results showed higher cytokine levels in children with dengue than without dengue, with statistically significant differences for IL-6 and IFN-gamma. No statistically significant differences were found between clinical forms, although IL-6 and IFN-gamma levels were higher in dengue fever cases than in dengue hemorrhagic fever cases. On the other hand, TNF-alpha levels were higher in dengue hemorrhagic fever than in dengue fever. The levels of IL-6 and TNF-alpha were higher in secondary infection than in primary infection, although IFN-gamma levels were higher in primary infection. These results suggest that IL-6, TNF-alpha and IFN-gamma are involved in dengue infection independently of the clinical form.
Restrepo
Berta Nelly
BN
Instituto Colombiano de Medicina Tropical-CES, Antioquia, Colombia. brestrepo@ces.edu.co
Isaza
Diana María
DM
Salazar
Clara Lina
CL
Ramírez
Ruth
R
Ospina
Marta
M
Alvarez
Luis Gonzalo
LG
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003715:Dengue / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D008297:Male; D019595:Severe Dengue / Q000097:blood / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000276:immunology
D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma