Scaffolded amino acids as a close structural mimic of type-3 copper binding sites.
We report the use of triazacyclophane (TAC)-scaffolded amino acids as a structural mimic for 3-histidine metal-binding sites in metalloproteins, especially for the mimicry of type-3 copper binding sites as are present in hemocyanin, tyrosinase and catechol oxidase.
Albada
H Bauke
HB
Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB Utrecht, The Netherlands.
Soulimani
Fouad
F
Weckhuysen
Bert M
BM
Liskamp
Rob M J
RM
D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D004156:Catechol Oxidase / Q000737:chemistry; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D006433:Hemocyanins / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D007202:Indicators and Reagents; D008667:Metalloproteins / Q000737:chemistry*; D008968:Molecular Conformation; D018716:Molecular Mimicry; D014442:Monophenol Monooxygenase / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman; D014732:Vibration
D000596:Amino Acids; D007202:Indicators and Reagents; D008667:Metalloproteins; D006639:Histidine; D003300:Copper; D006433:Hemocyanins; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase; D010100:Oxygen