[Effect of antihypoxants on the consumption of oxygen in animals with traumatic brain injury].
The effect of drugs on the dynamics of oxygen consumption in experimental animals with traumatic brain injury (TBI) has been measured. It is established that the antihypoxants bemithyl, amtizole, trymeen, and ethomersol in a dose of 25 mg/kg decrease the consumption of oxygen and reduced oxygen demands of tissues in the acute posttraumatic period. These phenomena can play a significant role in the mechanism of the protective action of drugs under conditions of TBI.
Novikov
V E
VE
Ponamareva
N S
NS
Kokhonov
K V
KV
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D002534:Hypoxia, Brain / Q000517:prevention & control*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013830:Thiadiazoles / Q000627:therapeutic use
D000975:Antioxidants; D001562:Benzimidazoles; D013830:Thiadiazoles; C070941:ethomersol; C044365:amtizol; C049825:bemethyl