title: [Antioxidant activity of condensed [1,2,4]-triazinone derivatives in nitrosative stress].
abstract: Antioxidant activity of nine [1,2,4]-triazinone derivatives was studied in the work. Our data show that [1,2,4]-triazinone derivatives with benzyl alcohol, propyl alcohol, me-thyl alcohol and tolyl residues in their structure have antioxidant activity in condition of in vitro NO formation. KO-17 compound proved to have the greatest antioxidant activity which exceeded N-acetyl cysteine's one.
authors: Iu I
authors: IuI
authors: Hubs'kyĭ
authors: I F
authors: IF
authors: Belenichev
authors: Ie L
authors: IeL
authors: Levyts'kyĭ
authors: V V
authors: VV
authors: Halytsia
authors: N V
authors: NV
authors: Bukhtiiarova
authors: S I
authors: SI
authors: Kovalenko
authors: L P
authors: LP
authors: Babenko
authors: O V
authors: OV
authors: Zadoryna
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008956:Models, Chemical; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000378:metabolism; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D020030:Nitric Oxide Donors; D014227:Triazines; D009569:Nitric Oxide; D013482:Superoxide Dismutase