title: Primary biliary cirrhosis complicated by polymyositis and pulmonary hypertension.
abstract: A 68-year-old woman was admitted to a hospital with pulmonary hypertension (PH) in August 2006. Perfusion scintigraphy of the lung was normal and showed no interstitial change. Liver dysfunction was noted and antinuclear antibodies (x1,280) were positive. In November 2006, muscle pain and weakness gradually developed in the brachial muscle and a quadriceps. She was referred and admitted to our hospital for elevated CPK and liver dysfunction in March 2007. She was diagnosed with polymyositis (PM) on the basis of the histological findings of muscle biopsy and treated with prednisolone. In addition, because anti-centromere antibodies and anti-mitochondrial M2 antibodies were positive with high titers, she was also diagnosed with primary biliary cirrhosis (PBC). Although PBC is often associated with other autoimmune diseases, there have been no reports of PBC complicated by PM and PH.
authors: Department of Internal Medicine II, Fukushima Medical University School of Medicine, Japan.
authors: Fumiko
authors: F
authors: Honma
authors: Kiori
authors: K
authors: Shio
authors: Kyoko
authors: K
authors: Monoe
authors: Yukiko
authors: Y
authors: Kanno
authors: Atsushi
authors: A
authors: Takahashi
authors: Junko
authors: J
authors: Yokokawa
authors: Hiroko
authors: H
authors: Kobayashi
authors: Hiroshi
authors: H
authors: Watanabe
authors: Atsushi
authors: A
authors: Irisawa
authors: Hiromasa
authors: H
authors: Ohira
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis*; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000175:diagnosis*; D017285:Polymyositis / Q000150:complications / Q000175:diagnosis*