title: Prevalence and significance of G6PD deficiency in patients of an urban HIV clinic.
abstract: The rationale to screen for glucose-6-phosphate dehydrogenase (G6PD) deficiency in HIV-infected individuals is their increased likelihood to receive oxidant drugs and subsequent potential of hemolytic events. However, current guidelines regarding who should be screened are conflicting. The authors examined the prevalence of G6PD deficiency and the frequency of hemolytic events in an urban HIV clinic. They used data from a military database as a comparison. In both cohorts, a relatively high number of black females were found to be G6PD deficient (10% and 13%), which was similar to the rate in men (15% and 12%). No white females were G6PD deficient. The authors identified 8 drug-related hemolytic events in HIV clinic patients. Two patients necessitated blood transfusions; both were triggered by trimethoprim/sulfamethoxazole (TMP/SMX). Although G6PD screening prior to the use of TMP/SMX is not often considered by clinicians, the authors' finding of 2 hemolytic events requiring transfusion suggests this would be beneficial.
authors: Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. tungsim@ccf.org
authors: Marisa
authors: M
authors: Tungsiripat
authors: Henning
authors: H
authors: Drechsler
authors: Christine
authors: C
authors: Sarlone
authors: Kathleen
authors: K
authors: Amyot
authors: Elizabeth
authors: E
authors: Laffey
authors: Judith
authors: J
authors: Aberg
mesh_terms: D000554:Ambulatory Care Facilities; D000743:Anemia, Hemolytic / Q000453:epidemiology; D044383:Black People; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005953:Glycogen Storage Disease Type I / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000208:ethnology; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008403:Mass Screening; D008889:Military Personnel; D015995:Prevalence; D014505:Urban Population; D044465:White People
chemical_list: D005954:Glucosephosphate Dehydrogenase