Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex.
Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF(6) revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 microM.
Niesel
Johanna
J
Lehrstuhl für Anorganische Chemie I-Bioanorganische Chemie, Ruhr-Universität Bochum NC 3/74, Universitätsstrasse 150, D-44801 Bochum, Germany.
Pinto
Antonio
A
Peindy N'Dongo
Harmel W
HW
Merz
Klaus
K
Ott
Ingo
I
Gust
Ronald
R
Schatzschneider
Ulrich
U
D002248:Carbon Monoxide / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D010777:Photochemistry; D011720:Pyrazoles / Q000737:chemistry*
D011720:Pyrazoles; D008345:Manganese; D002248:Carbon Monoxide