title: Chromatin dynamics and gene positioning.
abstract: The mammalian cell nucleus provides a landscape where genes are regulated through their organization and association with freely diffusing proteins and nuclear domains. In many cases, specific genes are highly dynamic, and the principles governing their movements and interchromosomal interactions are currently under intensive study. Recent investigations have implicated actin and myosin in chromatin dynamics and gene expression. Here, we discuss our current understanding of the dynamics of the interphase genome and how it impacts nuclear organization and gene activity.
authors: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
authors: R Ileng
authors: RI
authors: Kumaran
authors: Rajika
authors: R
authors: Thakar
authors: David L
authors: DL
authors: Spector
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007399:Interphase
chemical_list: D002843:Chromatin