[Polymethylene nucleic acid derivatives with omega-functional groups: vi. [8-(2-oxocyclohexyl)-9-oxooctyl]pyrimidines as potential inhibitors of pyrimidine phosphorylases].
New polymethylene derivatives of nucleic bases with beta-diketo function in omega-position were prepared by alkylation of uracil, thymine, and cytosine. Their physicochemical properties and effect on the E. coli uridine phosphorylase were studied.
Komissarov
V V
VV
Panova
N G
NG
Kritsyn
A M
AM
D004926:Escherichia coli / Q000201:enzymology*; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D014543:Uridine Phosphorylase / Q000037:antagonists & inhibitors* / Q000737:chemistry
D009696:Nucleic Acids; D011743:Pyrimidines; D014543:Uridine Phosphorylase