Solid-phase synthesis of tris-heteroleptic ruthenium(II) complexes and application to acetylcholinesterase inhibition.
A synthetic route with two consecutive coordination chemistry steps on a solid support affords tris-heteroleptic ruthenium(II) polypyridyl complexes with high purity and in good yields. As an application we report the identification of a nanomolar acetylcholinesterase inhibitor from a small ruthenium complex library synthesized on Lanterns.
Mulcahy
Seann P
SP
Philipps-Universität Marburg, Marburg, Germany. meggers@chemie.uni-marburg.de
Li
Shan
S
Korn
Ricarda
R
Xie
Xiulan
X
Meggers
Eric
E
D000110:Acetylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D002800:Cholinesterase Inhibitors; D046911:Macromolecular Substances; D011725:Pyridines; D054852:Small Molecule Libraries; D012428:Ruthenium; D000110:Acetylcholinesterase