title: Association study of TP53 polymorphisms with lung cancer in a Korean population.
abstract: The tumor suppressor gene, TP53, is located on chromosome 17p13.1 and is critical for DNA repair, cell-cycle control, and apoptosis. TP53 also plays a crucial function in the tumorigenesis of lung cancer. Inactivation of TP53 via genetic alterations such as missense mutations is often associated with lung cancer. In this study, potential association of TP53 polymorphisms with the risk of lung cancer was examined in a Korean population. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed, and logistic regression analyses were conducted to characterize the association between TP53 polymorphisms and lung cancer risk. Through direct sequencing in 24 Korean individuals, 13 sequence variants were identified, and five of these polymorphisms were selected for a larger-scale genotyping (n = 595). Statistical analyses revealed that polymorphisms and haplotypes in the TP53 gene, including Arg72Pro, were not significantly associated with lung cancer in a Korean population.
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Hae-Yun
authors: HY
authors: Jung
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Young Mi
authors: YM
authors: Whang
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Jae Sook
authors: JS
authors: Sung
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.|Department of Genetic Epidemiology, SNP Genetics, Inc, Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, Gasan-Dong, Geumcheon-Gu, Seoul, 371-28, South Korea.
authors: Hyoung Doo
authors: HD
authors: Shin
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.|Department of Genetic Epidemiology, SNP Genetics, Inc, Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, Gasan-Dong, Geumcheon-Gu, Seoul, 371-28, South Korea.
authors: Byung Lae
authors: BL
authors: Park
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Jun Suk
authors: JS
authors: Kim
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Sang Won
authors: SW
authors: Shin
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Hee Yun
authors: HY
authors: Seo
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea.
authors: Jae Hong
authors: JH
authors: Seo
authors: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Medical College, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, South Korea. yhk0215@korea.ac.kr.
authors: Yeul Hong
authors: YH
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016158:Genes, p53; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D004273:DNA, Neoplasm