title: The effectiveness of a damage control resuscitation strategy for vascular injury in a combat support hospital: results of a case control study.
abstract: OBJECTIVE
  Major vascular injury is a leading cause of potentially preventable hemorrhagic death in modern combat operations. An optimal resuscitation approach for military trauma should offer both rapid hemorrhage control and early reversal of metabolic derangements. The objective of this report is to establish the use and effectiveness of a damage control resuscitation (DCR) strategy in the setting of wartime vascular injury.
  
  
  METHODS
  A retrospective two-cohort case control study was performed using the Joint Theater Trauma Registry to identify patients with an extremity vascular injury treated at two different points in time: group 1 (n = 16) from April to June 2006 when DCR concepts were put into practice and group 2 (n = 24) 1 year later in a period when DCR strategies were not employed.
  
  
  RESULTS
  Baseline demographics, injury severity, admission physiology, and operative details were similar between groups 1 and 2. Group 1 patients received more total blood products (23 vs. 12 units, p < 0.05), fresh frozen plasma (16 vs. 7 units, p < 0.01), cryoprecipitate (11 vs. 1.2 units, p < 0.05), whole blood (19% vs. 0%, p = 0.06), and early recombinant factor VIIa (75% vs. 0%, p < 0.001) than group 2 patients. Group 1 patients had a more complete early physiologic recovery after vascular reconstruction (heart rate: 38 vs. 12, p < 0.001; systolic blood pressure, 39 vs. 14, p < 0.001; base deficit: 7.36 vs. 2.72, p < 0.001; International Normalized Ratio, 0.3 vs. 0.1, p < 0.001). There was no significant difference in early amputation rates (group 1: 6.2% vs. group 2: 4.2%) or 7-day mortality (0% in both groups).
  
  
  CONCLUSIONS
  This study was the first to use the Joint Theater Trauma Registry for follow-up on an established clinical practice guideline. DCR goals appear now to be met during the management of acute wartime vascular injuries with effective correction of physiologic shock. The overall impact of this resuscitation strategy on long-term outcomes such as limb salvage and mortality remains to be determined.
authors: Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA. charles.fox@us.army.mil
authors: Charles J
authors: CJ
authors: Fox
authors: David L
authors: DL
authors: Gillespie
authors: E Darrin
authors: ED
authors: Cox
authors: Sumeru G
authors: SG
authors: Mehta
authors: John F
authors: JF
authors: Kragh
authors: Jose
authors: J
authors: Salinas
authors: John B
authors: JB
authors: Holcomb
mesh_terms: D000293:Adolescent; D000328:Adult; D001134:Arm Injuries / Q000628:therapy*; D001158:Arteries / Q000293:injuries; D001803:Blood Transfusion; D015331:Cohort Studies; D005260:Female; D019983:Guideline Adherence; D006489:Hemostatic Techniques; D006801:Humans; D054542:Iraq War, 2003-2011; D007869:Leg Injuries / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome; D014481:United States; D014680:Veins / Q000293:injuries