[Investigation of radiation-induced "bystaner effect" using model of adaptive response in mixed lymphocyte culture from humans of different gender].
The novel method for the investigation of radiation-induced "bystander effect" has been tested on the model of mixed lymphocyte culture from humans of different gender. The "bystander effect" was estimated by the ability of nonirradiated female/male cells to develop an adaptive response in mixed culture with irradiated at the dose 0.05 Gy of X-rays G0 lymphocytes of opposite gender. The preliminary results indicate that both irradiated lymphocytes and non-irradiated but neighbouring with pre-exposed cells are less susceptible to the genetic damages manifested as chromosome aberrations induced in G1 lymphocytes by a subsequent high dose of X-ray (1.0 Gy). Direct adaptive response as well as indirect one were expressed more obvious in female lymphocytes.
Vorobtsova
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Kolesnikova
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D000222:Adaptation, Physiological / Q000528:radiation effects*; D000328:Adult; D024201:Bystander Effect / Q000528:radiation effects*; D002869:Chromosome Aberrations / Q000528:radiation effects; D018920:Coculture Techniques; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology / Q000528:radiation effects; D008297:Male