[Neurologic inflammation and oral disease. An aetiopathogenic hypothesis].
The nervous system contributes to the pathophysiology of peripheral inflammation and a neurogenic component has been implicated in many inflammatory disease, including oral diseases. Neurogenic inflammation should be regarded as a protective mechanism wich forms the first line of defense and protects tissue integrity. However, prolonged noxius stimulation may result in the inflammatory response. This review focuses on the evidence suggesting that neuropeptides have a pivotal role in the complex cascade of chemical activity associated with oral diseases. The pathophysiology is complex and neuropeptides are not solely responsible for the initiation and progression of the disease. However, since neuropeptides and inflammatory modulators are released together during the inflammatory response, it will be impossible to assign a specific role to each until work with selective antagonists is completed.
Scardina
Giuseppe Alessandro
GA
Dipartimento di Scienze Stomatologiche G. Messina, Università, Palermo. scardina@odonto.unipa.it
Ruggeri
Alessia
A
Messina
Pietro
P
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008833:Microcirculation; D009059:Mouth Diseases / Q000209:etiology* / Q000503:physiopathology; D009061:Mouth Mucosa; D020078:Neurogenic Inflammation / Q000150:complications* / Q000503:physiopathology; D009479:Neuropeptides / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000209:etiology; D051381:Rats; D013373:Substance P / Q000502:physiology; D013552:Swine; D014059:Tongue / Q000098:blood supply; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
D009479:Neuropeptides; D013373:Substance P; D014660:Vasoactive Intestinal Peptide