title: Organotin(IV) derivatives of L-cysteine and their in vitro anti-tumor properties.
abstract: The synthesis and characterization of the organotin compounds [(n-C(4)H(9))(2)Sn(cys)] (1), [(C(6)H(5))(2)Sn(cys)] (2), [(C(6)H(5))(3)Sn(Hcys).(H(2)o)] (3), {[(CH(3))(2)Sn(Kcys)(2)].2(H(2)0)} (4), {[(n-C(4)H(9))(2)Sn(Kcys)(2)].2(H(2)0)} (5) and {[(C(6)H(5))(2)Sn(Kcys)(2)].2(H(2)0)} (6) (where H(2)cys = L-cysteine) are reported. The compounds have been characterized by elemental analysis and (1)H-NMR, Uv-Vis, FT-IR and MOssbauer spectroscopic techniques. Attempted recrystallization of (2) in DMSO/methanol 2:1 solution yielded after several days unexpectedly the dimeric compound bis(tri-phenyltin)sulphide {[(C(6)H(5))(3)Sn](2)S} (7) which has been characterized by x-ray analysis. The structure of the parent complex (2) as well as the mechanism of the decomposition of cysteine are being further investigated. The in vitro anticancer activity of complexes (I)- (6), against human leukemia (HL60), human liver (Bel7402), human stomach (BGC823) and human cervix epithelial human carcinoma (Hela), nasopharyngeal carcinoma (KB) and lung cancer (PG) tumor cells, were evaluated.
authors: Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
authors: Christos T
authors: CT
authors: Chasapis
authors: Sotiris K
authors: SK
authors: Hadjikakou
authors: Achilles
authors: A
authors: Garoufis
authors: Nick
authors: N
authors: Hadjiliads
authors: Thomas
authors: T
authors: Bakas
authors: Maciej
authors: M
authors: Kubicki
authors: Yang
authors: Y
authors: Ming