title: [Biology of thioredoxin and its association with Alzheimer's disease and Parkinson's disease].
abstract: Thioredoxin (Trx) is a crucial protein for antioxidative defense, as well as a redox regulator of the intra- and extracellular signaling pathways and transcription factors. In this review, we focus on mammalian Trx and its association with Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the evidence of neuroprotective effects of Trx, up-regulation of Trx may be a good strategy for prevention and treatment of AD and PD.
authors: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors: Li-Bo
authors: LB
authors: Li
authors: Geng-Tao
authors: GT
authors: Liu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000502:physiology; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism*; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000378:metabolism*; D013879:Thioredoxins / Q000378:metabolism* / Q000502:physiology
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D013879:Thioredoxins