Caffeine and insulin sensitivity.
A number of reports have observed that acute caffeine ingestion decreases glucose tolerance and insulin sensitivity, and have raised the question whether its increased consumption throughout the world in the form of coffee and cola beverages might be of public health concern in the development of type 2 diabetes. Although some epidemiologic studies have found strong associations between coffee intake and detrimental lifestyle factors that favor obesity and diabetes, it is interesting that in spite of this, they have demonstrated that increased coffee consumption is associated with a decreased risk of developing type 2 diabetes. When lifestyle confounders are taken into account, individuals consuming >/=6 cups coffee per day have at least 50% less risk of developing type 2 diabetes than those consuming </=2 cups per day. Although it is perhaps premature to recommend increased coffee or caffeine intake to prevent the development of type 2 diabetes, there is little or no evidence to warrant the recommendation that it should not be a part of a normal healthy diet.
Acheson
Kevin J
KJ
Nutrition and Health Department, Nestlé Research Center, Lausanne, Switzerland.