title: Comparative study of 5 different membranes for guided bone regeneration of rabbit mandibular defects beyond critical size.
abstract: BACKGROUND
  Although several studies have examined use of collagen membranes in guided bone regeneration (GBR), none has examined the use of human fascia temporalis as a bioabsorbable barrier. The majority of studies related to GBR have examined critical size defects. We sought to assess the human fascia temporalis and other well-documented membranes applied for GBR in mandibular osseous defects beyond critical size.
  
  
  METHODS
  Fifty adult male New Zealand white rabbits were used in this study. Five groups of 10 animals each were used: HFL (human fascia lata membrane), HP (human pericardium), HFT (human fascia temporalis), BP (bovine pericardium), and PTFE (expanded polytetrafluoroethylene). Animals were killed 10 weeks after membrane application. In each animal, 9-mm circular mandibular defects were created bilaterally. On 1 side of the jaw, the defect was covered with 1 of the test membranes; the defect on the other side served as a control. Harvested specimens were examined histologically.
  
  
  RESULTS
  Membranes were significantly superior to the controls in all animals (P<0.001). Paired comparisons showed that groups HFL, HP, BP, and PTFE were significantly superior to HFT (P<0.05). Conversely, comparisons of HFL-HP, HFL-BP, HFL-PTFE, HP-BP, HP-PTFE, and BP-PTFE, showed no significant differences (P>0.05).
  
  
  CONCLUSIONS
  According to our results, the fascia temporalis is not recommended for GBR techniques. The fascia lata, human pericardium, bovine pericardium, and e-PTFE advance bone regeneration and can be successfully used as GBR membranes for osseous defects beyond the critical size.
authors: Clinic of Maxillofacial Surgery, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors: Vasilis
authors: V
authors: Thomaidis
authors: Kostas
authors: K
authors: Kazakos
authors: Dimitris N
authors: DN
authors: Lyras
authors: Ioannis
authors: I
authors: Dimitrakopoulos
authors: Nikolaos
authors: N
authors: Lazaridis
authors: Dimitrios
authors: D
authors: Karakasis
authors: Sotirios
authors: S
authors: Botaitis
authors: George
authors: G
authors: Agrogiannis
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002417:Cattle; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000145:classification / Q000473:pathology* / Q000601:surgery*; D008566:Membranes / Q000637:transplantation; D011817:Rabbits