title: Amyloid imaging in aged and young macaques with [11C]PIB and [18F]FDDNP.
abstract: [11C]PIB and [18F]FDDNP were examined on five aged and five young adult male rhesus macaques using positron emission tomography. Both tracers showed increased accumulation in the striatum, thalamus, cingulate and pons in the aged group. Compared to [11C]PIB, [18F]FDDNP showed higher accumulation in the cortical regions of aged animals as well as young animals. Although [18F]FDDNP may have possible usefulness for imaging, including other proteins, [11C]PIB may be better for amyloid imaging owing to lower non-specific binding.
authors: Basic Research Division, The Medical and Pharmacological Research Center Foundation, Hakui, Japan. anoda@mprcf.or.jp
authors: Akihiro
authors: A
authors: Noda
authors: Yoshihiro
authors: Y
authors: Murakami
authors: Shingo
authors: S
authors: Nishiyama
authors: Dai
authors: D
authors: Fukumoto
authors: Sosuke
authors: S
authors: Miyoshi
authors: Hideo
authors: H
authors: Tsukada
authors: Shintaro
authors: S
authors: Nishimura
mesh_terms: D000375:Aging / Q000502:physiology*; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D000818:Animals; D052160:Benzothiazoles / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D009570:Nitriles / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D013844:Thiazoles
chemical_list: C444520:2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile; C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D052160:Benzothiazoles; D009570:Nitriles; D013844:Thiazoles