title: Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum.
abstract: Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.
authors: Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75724 Paris Cedex 15, France. ahidjo.ayouba@mpl.ird.fr
authors: Ahidjo
authors: A
authors: Ayouba
authors: Cyril
authors: C
authors: Badaut
authors: Anfumbom
authors: A
authors: Kfutwah
authors: Claude
authors: C
authors: Cannou
authors: Alexandre
authors: A
authors: Juillerat
authors: Stéphane
authors: S
authors: Gangnard
authors: Charlotte
authors: C
authors: Behr
authors: Odile
authors: O
authors: Mercereau-Puijalon
authors: Graham A
authors: GA
authors: Bentley
authors: Françoise
authors: F
authors: Barré-Sinoussi
authors: Elisabeth
authors: E
authors: Menu
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000494:pharmacology*; D002448:Cell Adhesion; D002460:Cell Line; D005260:Female; D015658:HIV Infections / Q000382:microbiology* / Q000635:transmission; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D016778:Malaria, Falciparum / Q000276:immunology*; D010920:Placenta / Q000276:immunology / Q000469:parasitology / Q000821:virology; D010922:Placenta Diseases / Q000276:immunology / Q000469:parasitology / Q000821:virology; D010963:Plasmodium falciparum / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*; D014327:Trophoblasts / Q000469:parasitology / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000953:Antigens, Protozoan