title: [Synthetic therapy for keloid in aural region].
abstract: OBJECTIVE
  To summarize the effectiveness of surgical removal combined with adjuvant therapy on the aural region keloid.
  
  
  METHODS
  From January 2000 to December 2005, 42 patients (71 side ears) with keloid at the aural region were treated. There were 8 males and 34 females, aged 16 to 50 years (mean 26.2 years). The course of disease ranged from 6 months to 4 years. The causes of disease included earhole piercing (n=32), ear trauma (n=7), and postoperative hyperplasia (n=3); the sizes of keloids ranged from 0.3 cm x 0.3 cm x 0.2 cm to 6.0 cm x 4.0 cm x 1.0 cm withglobular, dumb-bell, nodular shapes. According to the different sizes and the range of keloids, different operations to remove the keloids and repair the defect tissue were chosen. Wounds were exposed to the electron beam at first 24 hours after operation, once a day at 2 Gy eachtime for 10 days. An immediate local injection for the keloid withhormones anti-scar drugs, whichwas a mixture of Beta-methasone (Diprospan) and 2% Lidocaine with a proportion of 1 : 3, was given to the patients who had recurrence trend 3 times, every 3 weeks.
  
  
  RESULTS
  After operation, all the wounds healed by first intention. And 37 cases (64 lateral ears) were followed up for 1 year, and all achieved clinical cure. Five cases (7 lateral ears) had the trend of recurrence 3-6 months after operation and were cured after the immediate local injection for the keloid with hormones anti-scar drugs. According to LIU Wenge's curative criterion, 37cases were cured and 5 cases responded to treatment.
  
  
  CONCLUSIONS
  Surgical removal combined withlocal radiation and hormones infiltrated individually as early as possible can effectively treat aural region keloids. And it is an optimal method.
authors: Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
authors: Xiaoxue
authors: X
authors: Liu
authors: Huaisheng
authors: H
authors: Wang
authors: Ying
authors: Y
authors: Cen
authors: Zhiping
authors: Z
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D004431:Ear, External; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007627:Keloid / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D018714:Radiotherapy, Adjuvant / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods; D055502:Secondary Prevention; D013524:Surgical Flaps; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids