Model study of the effects of interactions between systemic and peripheral circulation on interstitial fluid balance.
Interstitial fluid balance is severely altered in microgravity, but the mechanisms underlying the fluid shift from lower to upper body are still partially unclear. A lumped parameter model of the arterial tree with active and non linear modulation of peripheral resistances and capillary fluid exchange was adopted to simulate the response of microcirculation to pulsatility and edema. Results suggest that myogenic regulation not only impinges on arteriolar radius, but it also indirectly affects interstitial fluid balance. Non linear dynamics of blood pressure (BP) and flow in capillary beds are influenced by systemic pulsatility, hinting that local activity is involved in the response to peripheral edema as well.
Aletti
Federico
F
Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 32-20133 Milano, Italy. federico.aletti@polimi.it
Baselli
Giuseppe
G
D001158:Arteries / Q000503:physiopathology; D001794:Blood Pressure; D002196:Capillaries / Q000503:physiopathology; D002199:Capillary Permeability; D003198:Computer Simulation; D004244:Dizziness / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D004487:Edema / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D045604:Extracellular Fluid / Q000378:metabolism*; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D013026:Space Flight; D013997:Time Factors; D014655:Vascular Resistance; D014882:Water-Electrolyte Balance; D014893:Weightlessness / Q000009:adverse effects*