title: Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex.
abstract: Uchida et al. show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephrin is reduced, and this is accompanied by a decrease in F-actin in glomeruli. This, together with previous studies, suggests that the nephrin protein complex is a signaling nexus that regulates actin dynamics in podocytes.
authors: Haartman Institute, University of Helsinki, Helsinki, Finland. sanna.h.lehtonen@helsinki.fi
authors: S
authors: S
authors: Lehtonen
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009401:Nephrosis / Q000378:metabolism*; D010766:Phosphorylation; D050199:Podocytes / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000199:Actins; D008565:Membrane Proteins; C113267:nephrin; D011505:Protein-Tyrosine Kinases