title: Intravitreal triamcinolone reduces the morphologic changes of ciliary body after pars plana vitrectomy for retinal vascular diseases.
abstract: OBJECTIVE
  To investigate the early postoperative changes in ciliary body after pars plana vitrectomy (PPV) for retinal vascular disease and to determine whether intravitreal triamcinolone acetonide (IVTA) affects postvitrectomy changes of the ciliary body.
  
  
  METHODS
  Prospective interventional case-control study.
  
  
  METHODS
  We recruited 46 patients who underwent uncomplicated PPV for retinal vascular disease (35 with proliferative diabetic retinopathy (PDR) and 11 with branch retinal vein occlusion) and divided the patients into two groups according to the use of IVTA at the end of the PPV. The morphologic changes of the anterior segments were measured by ultrasound biomicroscopy (UBM) one day before and one day, two days, three days, five days, two weeks, one month, and two months after the PPV. The main outcome measures were the thickness and area of the ciliary body, the frequency of supraciliary effusions (SEs), angle-opening, and anterior chamber depth (ACD). We compared the UBM parameters between the two groups.
  
  
  RESULTS
  The thickness and area of the ciliary body significantly increased from day 1 to day 5 postoperatively. Nineteen of 46 eyes had SEs that were frequently associated with divergent alterations of postoperative intraocular pressure (IOP). The angle-opening and ACD were significantly decreased and dependent upon the findings of ciliary body thickness and SEs. The degree of the morphologic changes of the ciliary body and the frequency of SEs were significantly lower and of shorter duration in the IVTA group compared to the non-IVTA group.
  
  
  CONCLUSIONS
  The PPV for retinal vascular disease induces the morphologic changes of the ciliary body associated with postoperative abnormalities in IOP during the early postoperative period. Administration of IVTA at the end of the PPV effectively reduces or shortens the duration of the postvitrectomy changes of the ciliary body.
authors: Department of Ophthalmology, Chonnam National University Medical School, 8 Hakdong, Donggu, Gwangju, Korea.
authors: Gwang Hoon
authors: GH
authors: Lee
authors: Jae Kyoun
authors: JK
authors: Ahn
authors: Yeoung Geol
authors: YG
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002924:Ciliary Body / Q000000981:diagnostic imaging / Q000187:drug effects*; D003930:Diabetic Retinopathy / Q000601:surgery; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012164:Retinal Diseases / Q000601:surgery*; D012170:Retinal Vein Occlusion / Q000601:surgery; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014603:Uveal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D014821:Vitrectomy; D014822:Vitreous Body
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide