title: High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor.
abstract: Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required less than 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses of compound libraries.
authors: ThalesNano Inc., Záhony u. 7., Budapest, Hungary. csaba.csajagi@thalesnano.com
authors: Csaba
authors: C
authors: Csajági
authors: Bernadett
authors: B
authors: Borcsek
authors: Krisztián
authors: K
authors: Niesz
authors: Ildikó
authors: I
authors: Kovács
authors: Zsolt
authors: Z
authors: Székelyhidi
authors: Zoltán
authors: Z
authors: Bajkó
authors: László
authors: L
authors: Urge
authors: Ferenc
authors: F
authors: Darvas
mesh_terms: D000588:Amines / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D006358:Hot Temperature; D011312:Pressure
chemical_list: D000588:Amines; D002264:Carboxylic Acids; D002248:Carbon Monoxide