title: Extracorporeal membrane oxygenation with danaparoid sodium after massive pulmonary embolism.
abstract: During extracorporeal membrane oxygenation, anticoagulation therapy is usually achieved with unfractionated heparin. We report on an extracorporeal membrane oxygenation with danaparoid sodium for a patient with severe respiratory failure due to massive pulmonary embolism and suspected type 2 heparin-induced thrombocytopenia. Danaparoid, a low molecular weight heparinoid, is an alternative to heparin for patients who develop type 2 heparin-induced thrombocytopenia. Danaparoid was given at 400 IU/h with an objective of antifactor Xa activity of 0.6-0.8 U/mL, which was monitored twice a day. No excessive bleeding or clotting of the circuit was noted. The patient was weaned from extracorporeal membrane oxygenation after 9 days of treatment.
authors: Université Claude Bernard Lyon 1, France. christian.bauer@chu-lyon.fr
authors: Christian
authors: C
authors: Bauer
authors: Zuzana
authors: Z
authors: Vichova
authors: Patrick
authors: P
authors: Ffrench
authors: Christiane
authors: C
authors: Hercule
authors: Olivier
authors: O
authors: Jegaden
authors: Olivier
authors: O
authors: Bastien
authors: Jean-Jacques
authors: JJ
authors: Lehot
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D003871:Dermatan Sulfate / Q000627:therapeutic use*; D017548:Echocardiography, Transesophageal; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D015951:Factor Xa / Q000187:drug effects / Q000378:metabolism; D006497:Heparan Sulfate / Q000627:therapeutic use*; D006801:Humans; D007084:Iliac Vein; D008297:Male; D011169:Portal Vein; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013921:Thrombocytopenia; D013927:Thrombosis; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D015951:Factor Xa; D006497:Heparan Sulfate; C035838:danaparoid