title: Colostrinin decreases hypersensitivity and allergic responses to common allergens.
abstract: BACKGROUND
  Colostrinin (CLN), isolated from mothers' pre-milk fluid (colostrum), is a uniform mixture of low-molecular-weight, proline-rich polypeptides. CLN induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits beta-amyloid-induced apoptosis and improves cognitive functions when administered to Alzheimer's disease patients.
  
  
  OBJECTIVE
  The aim of this study was to investigate potential allergic responses to CLN and its impact on allergic sensitization and inflammation caused by common allergens.
  
  
  METHODS
  We used a well-characterized mouse model of allergic airway inflammation. Changes in IgE/IgG1 and mucin levels, airway eosinophilia and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, respectively.
  
  
  RESULTS
  CLN did not increase IgE/IgG1 levels or induce cutaneous hypersensitivity reaction, airway inflammation and mucin production. Importantly, CLN significantly (p < 0.001) decreased IgE/IgG1 production, airway eosinophilia, mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites.
  
  
  CONCLUSIONS
  CLN itself is non-allergenic; however, it is effective in preventing allergic responses to known indoor and outdoor allergens. These data support the safe application of CLN and its potential use in the prevention of allergic inflammation in humans.
authors: Department of Microbiology, University of Texas Medical Branch, Galveston, TX 77555, USA. sboldogh@utmb.edu
authors: Istvan
authors: I
authors: Boldogh
authors: Leopoldo
authors: L
authors: Aguilera-Aguirre
authors: Attila
authors: A
authors: Bacsi
authors: Barun K
authors: BK
authors: Choudhury
authors: Alfredo
authors: A
authors: Saavedra-Molina
authors: Marian
authors: M
authors: Kruzel
mesh_terms: D031164:Ambrosia / Q000276:immunology*; D000818:Animals; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006967:Hypersensitivity / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D009077:Mucins / Q000032:analysis / Q000276:immunology; D010455:Peptides / Q000494:pharmacology*; D010993:Plethysmography, Whole Body; D039981:Pyroglyphidae / Q000276:immunology*; D012882:Skin Tests
chemical_list: D007074:Immunoglobulin G; D036341:Intercellular Signaling Peptides and Proteins; D009077:Mucins; D010455:Peptides; C105874:colostrinine; D007073:Immunoglobulin E