Detection of soluble HLA-G and its correlation with kidney transplant outcome.
We showed a protective effect of soluble HLA-G in sera of kidney transplant patients, confirming the statement that sHLA-G plays a role in the regulation of the immune system, leading to a better acceptance of the graft. Our results also suggest that determining sHLA-G concentration in serum could help to correlate in a better way the expression of this molecule and its protective effect since it has been demonstrated a concentration-dependent effect. The relationship between the production of HLA antibodies and the expression of sHLA-G is not clear, however, since there is not much information regarding this. Further studies are required in order to have more sources for better conclusions and to keep describing precisely the properties of this molecule.
Kaneku
Hugo
H
Terasaki Foundation Laboratory, Los Angeles, CA, USA.
D006085:Graft Survival; D006680:HLA Antigens / Q000097:blood* / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood* / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I