Genetic variations and gene expression of transporters in drug disposition and response.
BACKGROUND
The importance of transporters in drug disposition and response has led to increasing interest in genetic variations and expression differences of their genes.


OBJECTIVE
This review summarizes: i) genetic variations in transporters and associated drug response; and ii) a pharmacogenomic approach to correlate transporter expression and drug response.


METHODS
Several transporters in ATP-binding cassette family and solute carrier family are discussed.


CONCLUSIONS
The field of transporter pharmacogenomics is in its early stage. Transporter expression at mRNA levels could be more directly related to their functions and more practical to be assayed in high throughput. Correlating microarray expression of transporters with anticancer drug activity in the NCI-60 panel has provided an approach for identifying drug-transporter relationships and predicting drug response.
Huang
Ying
Y
Western University of Health Sciences, College of Pharmacy, Department of Pharmaceutical Sciences, Pomona, CA 91766, USA. yhuang@westernu.edu
Penchala
Sravan
S
Pham
Anh-Nhan
AN
Wang
Jeffrey
J
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D026901:Membrane Transport Proteins / Q000235:genetics; D027361:Organic Anion Transporters / Q000235:genetics; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D058978:Reduced Folate Carrier Protein
D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D027381:Liver-Specific Organic Anion Transporter 1; D026901:Membrane Transport Proteins; D027361:Organic Anion Transporters; D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; C503999:SLCO1B1 protein, human