title: Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0.
abstract: New findings in this issue of Cell Stem Cell by Qian et al. (2007) and Yoshihara et al. (2007) reveal that thrombopoietin modulates hematopoietic stem cell (HSC) cell-cycle progression at the osteoblast surface, linking a single cytokine with a specific postnatal niche cell. These observations indicate that simultaneous stimulation and suspension in a G(0) state are critical for maintenance of the HSC pool.
authors: Haverford College, Haverford, PA 19041, USA. semerson@haverford.edu
authors: Stephen G
authors: SG
authors: Emerson
mesh_terms: D000818:Animals; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010006:Osteoblasts / Q000502:physiology*; D016192:Resting Phase, Cell Cycle / Q000502:physiology*; D013926:Thrombopoietin / Q000494:pharmacology / Q000502:physiology*
chemical_list: D013926:Thrombopoietin