title: Body mass index and its association with genitourinary disorders in men undergoing prostate cancer screening.
abstract: BACKGROUND
  Elevated body mass index (BMI) may predispose to several pelvic pathologies.
  
  
  OBJECTIVE
  We tested the association between BMI and five end points, namely, (i) erectile dysfunction (ED); (ii) lower urinary tract symptoms (LUTS); (iii) chronic prostatitis-associated pain (CPP); and ejaculatory dysfunction that is subdivided between (iv) pain/discomfort on ejaculation; and (v) subjectively decreased ejaculate volume.
  
  
  METHODS
  Age, height, and weight were prospectively recorded in a cohort of 590 consecutive healthy men undergoing prostate cancer screening. Continuously coded and categorized BMI (World Health Organization classification) were studied.
  
  
  METHODS
  Age-adjusted analyses relied on logistic and linear regression models, according to data type.
  
  
  RESULTS
  The average age was 54.1 years (range 30-83). Of all, 296 were overweight (50.2%, BMI 25-29.9 kg/m(2)) and 85 were obese (14.4%, BMI > or = 30 kg/m(2)). After age adjustment, elevated continuously coded BMI (P < 0.001) and elevated categorized BMI (P = 0.01) were associated with worse erectile function. Conversely, after age adjustment, elevated continuously coded BMI (P = 0.02) and elevated categorized BMI (P = 0.05) were associated with a lower rate of subjectively decreased ejaculate volume. Finally, after age adjustment, elevated categorically coded BMI was related to lower rates of CPP (P < 0.001) and to a lower rate of pain/discomfort on ejaculation (P = 0.03).
  
  
  CONCLUSIONS
  In men undergoing prostate cancer screening, the effect of BMI on the five end points is not invariably detrimental. Elevated BMI may predispose to ED, but may also decrease the rate of pain/discomfort on ejaculation and may lower the reported rate of subjectively decreased ejaculate volume. Finally, it appeared to have no effect on LUTS.
authors: Cancer Prognostics and Health Outcomes unit, University of Montreal Health Center, Montreal, Quebec, Canada.
authors: Naeem
authors: N
authors: Bhojani
authors: Paul
authors: P
authors: Perrotte
authors: Georg
authors: G
authors: Hutterer
authors: Nazareno
authors: N
authors: Suardi
authors: Claudio
authors: C
authors: Jeldres
authors: Shahrokh F
authors: SF
authors: Shariat
authors: Umberto
authors: U
authors: Capitanio
authors: Philippe
authors: P
authors: Arjane
authors: Hugues
authors: H
authors: Widmer
authors: Francois
authors: F
authors: Benard
authors: Francois
authors: F
authors: Peloquin
authors: Francesco
authors: F
authors: Montorsi
authors: Pierre
authors: P
authors: Karakiewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000175:diagnosis* / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D011792:Quebec