Leukemic transformation of Langerhans cell sarcoma.
A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of disease progression 7 months after the initial diagnosis. Tumor cells in the leukemic phase expressed CD5, CD7, CD13, CD33, CD34, CD68, and CD123. These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia.
Sumida
Kousuke
K
Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
Yoshidomi
Yuya
Y
Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
Koga
Hiroko
H
Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
Kuwahara
Nobuo
N
Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
Matsuishi
Eijo
E
Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan.
Karube
Kennosuke
K
Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
Oshima
Koichi
K
Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
Gondo
Hisashi
H
Department of Hematology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga, 840-8571, Japan. gondou@koseikan.jp.
D015703:Antigens, CD / Q000276:immunology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D054752:Langerhans Cell Sarcoma / Q000276:immunology / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015703:Antigens, CD