title: Double invasive fungal infection and typhlitis in children with acute lymphoblastic leukemia.
abstract: Invasive fungal infection is one of the major causes of morbidity and mortality in immunocompromised patients. The occurrence of two invasive fungal infections in one patient at the same time is quite rare. Here the authors report on two adolescent patients with acute lymphoblastic leukemia who developed combined invasive pulmonary aspergillosis and hepatosplenic candidiasis during chemotherapy. They were treated with liposomal amphotericin B, but one of them died due to massive pulmonary hemorrhage during recovery from neutropenia.
authors: Department of Pediatric Hematology, Baskent University Faculty of Medicine, Ankara, Turkey. zekaiavci@yahoo.com
authors: Zekai
authors: Z
authors: Avci
authors: Bulent
authors: B
authors: Alioglu
authors: Deniz
authors: D
authors: Anuk
authors: Ozlem Yilmaz
authors: OY
authors: Ozbek
authors: Ozlem Kurt
authors: OK
authors: Azap
authors: Namik
authors: N
authors: Ozbek
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D002177:Candidiasis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology; D011859:Radiography; D013158:Splenic Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D053706:Typhlitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B