Effects of aluminum on insulin-like growth factor I levels and antioxidant status.
BACKGROUND
The aim of this research was to investigate the toxic effects of aluminum (Al) on plasma insulin-like growth factor I (IGF-I) levels and on the liver, the main production site of IGF-I. In addition, we analyzed the influence of Al on liver malondialdehyde (MDA) and glutathione (GSH) levels, and how the antioxidant vitamin E (vit E) affects the altered levels of these parameters.


METHODS
Adult male rats (n = 28) were randomly divided into the following four groups: Al alone, Al + vit E, vit E alone, and untreated control group. The Al group received 1 mg/200 g body weight of aluminum sulfate (AlSO4) thrice weekly for two weeks. The Al + vit E group received the same dose of AlSO4 plus 100 mg/kg of vit E once daily. The Vit E group received a daily dose of vit E alone. Control animals received physiologic saline daily.


RESULTS
Liver GSH levels were decreased in the Al group but recovered with vit E administration. Liver IGF-I levels significantly decreased in the Al group compared with the control. With the use of vit E, the liver IGF-I levels increased, but this increase was not statistically significant.


CONCLUSIONS
The results of this study show that plasma and liver IGF-I levels decrease with Al use. Also liver GSH levels decreased with Al while this recovered with vit E use together with Al.
Kaptanoğlu
Bünyamin
B
Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey. bkaptan61@yahoo.com
Turgut
Sebahat
S
Turgut
Günfer
G
Emmungil
Gülten
G
Demir
Süleyman
S
D000534:Alum Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D007124:Immunoenzyme Techniques / Q000379:methods; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011897:Random Allocation; D014810:Vitamin E / Q000494:pharmacology
D000534:Alum Compounds; D000975:Antioxidants; D014810:Vitamin E; C041524:aluminum sulfate; D008315:Malondialdehyde; D007334:Insulin-Like Growth Factor I; D005978:Glutathione