title: [Multiple system atrophy and Alzheimer's disease: a case report of a rare association of two neuro-degenerative disorders].
abstract: Multiple system atrophy (MSA) is a neurodegenerative disorder typically characterised by cerebellar dysfunction, parkinsonism, pyramidal signs and dysautonomy. Cognitive impairement is usually limited to a moderate subcortical dysexecutive syndrom. We report the case of a 62-year-old woman suffering from MSA who progressively developed severe dementia. Neuropathological examination confirmed the diagnosis of definite MSA and also showed histopathological hallmarks of Alzheimer's disease. This association is extremely rare in the literature. Our observation confirmes that franc dementia in MSA should prompt a search for another associated cause and underlines the usefulness of neuropathological verifications in atypical clinical pictures.
authors: Service de Neurologie, Hôpital Thomayer, Prague, République tchèque. robert.rusina@ftn.cz
authors: R
authors: R
authors: Rusina
authors: F
authors: F
authors: Bourdain
authors: R
authors: R
authors: Matej
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications* / Q000473:pathology*; D058225:Plaque, Amyloid / Q000473:pathology