CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
Wray
Bradley N
BN
Menzies Research Institute, University of Tasmania, Tasmania, Australia.
Stankovich
Jim
J
Whittock
Lucy
L
Dwyer
Terence
T
Ponsonby
Anne-Louise
AL
van der Mei
Ingrid A F
IA
Taylor
Bruce
B
Dickinson
Joanne
J
Foote
Simon
S
McMorran
Brendan J
BJ
D015703:Antigens, CD / Q000235:genetics*; D001315:Australia / Q000453:epidemiology; D060908:CTLA-4 Antigen; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D006684:HLA-DR Antigens