IBD in children: lessons for adults.
When children develop inflammatory bowel disease (IBD), physicians and researchers are presented with a singular opportunity to understand the nature of these chronic, idiopathic illnesses in the earliest stages. Genetic susceptibility factors tend to be common, whereas complicating environmental factors such as cigarette smoking are generally not an issue. As opposed to the case in adult patients, Crohn's disease is usually diagnosed in children at an early, inflammatory phase of the disease. Pediatric ulcerative colitis tends to present with more severe and more extensive involvement than in adults. In both forms of IBD, the severity of disease activity often dictates the need for early aggressive nutritional, immunomodulatory, and biologic therapy. As a result, the lessons learned from the evaluation and treatment of children with IBD are critically important to the clinician caring for adults with the same disorders.
Haller
Cindy A
CA
Schneider Children's Hospital, 269-01 76th Avenue, CH-234, New Hyde Park, NY 11040, USA. challer97@hotmail.com
Markowitz
James
J
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers; D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D003424:Crohn Disease / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D004750:Enteral Nutrition; D020022:Genetic Predisposition to Disease; D006801:Humans; D000069285:Infliximab; D016399:Lymphoma, T-Cell / Q000139:chemically induced; D018529:Nutritional Support; D011379:Prognosis; D012075:Remission, Spontaneous
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D000069285:Infliximab; D001379:Azathioprine