Outcome of 234 pregnancies in 140 renal transplant recipients from five middle eastern countries.
OBJECTIVE
To study the pregnancy and offspring outcomes in postrenal transplant recipients.


METHODS
This is a retrospective case-note review study investigating the outcome of 234 pregnancies in 140 renal transplant recipients from five different Middle Eastern countries.


RESULTS
Of the overall pregnancies 74.4% were successful albeit with high prevalences of preterm and Caesarean deliveries (40.8% and 53%, respectively). The mean serum creatinine did not rise significantly during pregnancy in the group as a whole but did so in patients who had serum creatinine of or above 150 micromol/L at the beginning of their pregnancies. The mean birth weight was (2,458 g) with 41.3% of the newborns being of low birth weight (<2,500 g). The prevalences of stillbirths were 7.3% and of spontaneous abortion was 19.3%. Preeclampsia and gestational diabetes were observed in 26.1% and 2% of pregnancies, respectively.


CONCLUSIONS
In the presence of good allograft function, the majority of pregnancies in renal transplant recipients have a good outcome but with increased incidence of preeclampsia, reduced gestational age, and low birth weights. Patients with baseline serum creatinine of above 150 micromol/L have an increased risk of allograft dysfunction resulting from the pregnancy.
Al Duraihimh
Huda
H
Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Ghamdi
Ghormullah
G
Moussa
Dujana
D
Shaheen
Faissal
F
Mohsen
Nabil
N
Sharma
Usha
U
Stephan
Antoine
A
Alfie
Adnan
A
Alamin
Mohamed
M
Haberal
Mehmet
M
Saeed
Bassam
B
Kechrid
Mohamed
M
Al-Sayyari
Abdulla
A
D000022:Abortion, Spontaneous / Q000453:epidemiology; D002585:Cesarean Section / Q000706:statistics & numerical data; D003404:Creatinine / Q000097:blood; D005260:Female; D005865:Gestational Age; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D008877:Middle East; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D050497:Stillbirth / Q000453:epidemiology
D003404:Creatinine