Mitochondria, oxidative stress and PARP-1 network: a new target for neuroprotective effects of tetracyclines?
Orsucci
Daniele
D
Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy. d.orsucci@sssup.it
Mancuso
Michelangelo
M
Siciliano
Gabriele
G
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D013754:Tetracyclines / Q000494:pharmacology* / Q000627:therapeutic use
D018696:Neuroprotective Agents; D013754:Tetracyclines; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases