Facile and efficient synthesis of carbohybrids as stereodivergent druglike small molecules.
A facile and efficient one-pot synthesis of acyclic polyols fused with pyrazolo[1,5-a]pyrimidines and 1,2,4-triazolo[1,5-a]pyrimidines as novel carbohybrids with regioselectivity was achieved through the condensation of 2-C-formyl glycals with 3-aminopyrazoles and 3-amino-1,2,4-triazoles in excellent yields under the microwave irradiation.
Sagar
Ram
R
Department of Chemistry, Seoul National University, Seoul 151-747 Korea.
Park
Seung Bum
SB
D001554:Benzene / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D006031:Glycosylation; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry
D004364:Pharmaceutical Preparations; D011720:Pyrazoles; D011743:Pyrimidines; D014230:Triazoles; C527752:pyrazolo(1,5-a)pyrimidine; D002244:Carbon; D001554:Benzene