title: Selective synthesis of 4-alkylidene-beta-lactams and N,N'-diarylamidines from azides and aryloxyacetyl chlorides via a ketenimine-participating one-pot cascade process.
abstract: A one-pot cascade approach to 4-alkylidene-beta-lactams and N, N'-diarylamidines from aryl azides and aryloxyacetyl chlorides has been developed. The chemical outcome of the reaction can be controlled selectively by an appropriate choice of the stoichiometric ratio of different substrates and reagents. The products should find use in pharmaceutical discovery, especially in the development of new antimicrobial agents against multidrug-resistant pathogens.
authors: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors: Yun-Yun
authors: YY
authors: Yang
authors: Wang-Ge
authors: WG
authors: Shou
authors: Deng
authors: D
authors: Hong
authors: Yan-Guang
authors: YG
authors: Wang
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000215:Acylation; D000478:Alkylation; D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007649:Ketamine / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000085:Acetates; D000578:Amidines; D001386:Azides; D002712:Chlorides; D047090:beta-Lactams; D007649:Ketamine; C081124:acetyl chloride; D010100:Oxygen