Amyotrophic lateral sclerosis from bench to bedside.
Amyotrophic lateral sclerosis (ALS) is a progressive disease for which there are currently no significant treatments to alter the fatal outcome. The cause of the disease is still elusive, except in familial cases where significant advances have been made in identifying new genetic causes. ALS is a relatively rare disease affecting approximately 1 in 100,000 people equally across geographic and ethnic distributions. It is a difficult disease to diagnose, and there are many mimics of ALS. Overlap with dementia may provide new clues to the etiology and treatment. There have been many advances in symptomatic treatments and improvements in the quality of life for ALS patients due to technological advancements.
Lomen-Hoerth
Catherine
C
Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 500, San Francisco, CA 94117, USA. catherine.lomen-hoerth@ucsf.edu
D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008134:Long-Term Care / Q000379:methods / Q000592:standards; D009046:Motor Neurons / Q000378:metabolism* / Q000473:pathology; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D015415:Biomarkers