[Specific bradycardic drug zatebradin: cardiac rhythm variability, antifibrillatory, and antiischemic effects].
The results of experiments on narcotized cats and rats showed that the drug zatebradin produces a specific bradycardic action by reducing the heart rate and the double product, while virtually not influencing vitally important parameters of the heart activity such as the cardiac output and the mean acceleration of the aorta blood flow. The drug reduced the rise of ST segment recorded in multiple epicardial ECG leads made in narcotized cats during a 5-min occlusion of the anterior descending branch of the left coronary artery. Zatebradin was found to increase the cardiac rhythm variability in narcotized rats and decrease the rate of ventricular fibrillations during a 7-min occlusion with the subsequent 3-min coronary artery reperfusion.
Tsorin
I B
IB
Palka
I P
IP
Kirsanova
G Iu
GIu
Chichkanov
G G
GG
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology* / Q000627:therapeutic use; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D002415:Cats; D003326:Coronary Circulation; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000503:physiopathology
D001552:Benzazepines; C043636:zatebradine