Association between herpes simplex virus-1 infection and idiopathic unilateral facial paralysis in children and adolescents.
We studied the association between herpes simplex virus-1 (HSV-1) infection and Bell palsy in children. Thirty-three of 42 affected patients had a positive HSV-1 enzyme-linked immunosorbent assay compared with 16 of 41 controls (P = 0.0003). Ten of 47 affected patients had a positive HSV-1 polymerase chain reaction compared with 4 of 45 of controls (P = 0.08). Our findings support an association between HSV-1 infection and Bell palsy in children.
Khine
Hnin
H
Division of Emergency Medicine, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein of College Medicine, Bronx, NY 10461, USA.
Mayers
Marguerite
M
Avner
Jeffrey R
JR
Fox
Amy
A
Herold
Betsy
B
Goldman
David L
DL
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D020330:Bell Palsy; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006561:Herpes Simplex / Q000150:complications*; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D012463:Saliva / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G