title: Hippocampal dysfunction during free word association in male patients with schizophrenia.
abstract: In schizophrenia, speech production deficits in patients with positive formal thought disorder (FTD e.g. loosening of associations and derailment) have been attributed to impairments in the semantic network. The brain area implicated in the retrieval of associated (i.e. relational) concepts is the hippocampus, a key region in the psychopathology of schizophrenia. However, its role in schizophrenic speech production and FTD in particular is yet little understood. To investigate the neural correlates of associative verbal retrieval, twelve patients with schizophrenia with varying degrees of FTD and twelve matched healthy control subjects underwent a free verbal association (FVA), a semantic (SVF) and a phonological verbal fluency (PVF) task while brain activity was measured with fMRI. The tasks varied in the relational binding operations needed for linking the stimulus to the respective response. Compared to control subjects, patients revealed attenuated left hippocampal activity during both semantic word generation tasks (FVA, SVF). Contrasting verbal fluency with FVA, a failure in recruiting the anterior cingulate gyrus emerged in the patient group. A negative correlation was found between right middle temporal activity and the severity of FTD during FVA. The hippocampus seems to play a major role in word generation. In schizophrenia, attenuated hippocampal activity during semantic tasks strengthens the hypothesis of impaired relational memory processes, affecting thought and language.
authors: Department of Psychiatry, RWTH Aachen University, Pauwelsstr. 30, D-52074 Aachen, Germany. tkircher@ukaachen.de
authors: Tilo
authors: T
authors: Kircher
authors: Carin
authors: C
authors: Whitney
authors: Timo
authors: T
authors: Krings
authors: Walter
authors: W
authors: Huber
authors: Susanne
authors: S
authors: Weis
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology*; D006624:Hippocampus / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010153:Paired-Associate Learning; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D012565:Schizophrenic Psychology; D012660:Semantics; D014705:Verbal Behavior / Q000502:physiology*
chemical_list: D010100:Oxygen