Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: a case report.
Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of the BRAFVK600-1E mutation, the molecular hallmark of the solid variant of PTC. Histological and molecular evaluation of the surgical specimen confirmed this pre-operative diagnosis. Thus combining cytology to BRAF molecular analysis is useful to refine the cytological diagnosis of this variant also on FNC specimens.
Troncone
Giancarlo
G
Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli studi di Napoli Federico II, 80131 Naples, Italy. giancarlo.troncone@unina.it
Russo
Maria
M
Malapelle
Umberto
U
Accardo
Marina
M
Ferraro
Angelo
A
Cozzolino
Immacolata
I
Palombini
Lucio
L