Utility of 4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide in the synthesis of novel quinolines as possible anticancer and radioprotective agents.
The present work reports the possible utility of 4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide in the synthesis of some novel 4-(quinolin-1-yl) benzenesulfonamide derivatives (6a-o). Structures of the newly synthesized compounds were confirmed by elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their in vitro anticancer activity. Compounds 6k, 6j and 6m showed interesting cytotoxic activity compared with doxorubicin (CAS 23214-922-8) as a reference drug. Additionally, compound 6c exhibited in vivo radioprotective activity, against gamma-irradiation, in mice.
Ghorab
Mostafa M
MM
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt. mmsghorab@yahoo.com
Ragab
Fatma A
FA
Noaman
Eman
E
Heiba
Helmy I
HI
El-Hossary
Ebaa M
EM
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000097:blood; D014407:Tumor Cells, Cultured; D000096926:Benzenesulfonamides
D000970:Antineoplastic Agents; D004317:Doxorubicin; D005978:Glutathione; D007202:Indicators and Reagents; D008315:Malondialdehyde; D011804:Quinolines; D011837:Radiation-Protective Agents; D013449:Sulfonamides; D013482:Superoxide Dismutase; C528606:4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide; D000096926:Benzenesulfonamides