Association study of serotonin system genes in childhood-onset mood disorder.
BACKGROUND
The serotonin system has been implicated in neuropsychiatric disorders, including mood disorders.


METHODS
We investigated polymorphisms in two serotonin-receptor genes, HTR1B and HTR2A, and the serotonin transporter (SLC6A4) in two independent samples of patients with childhood-onset mood disorders (COMD): 203 patients from Pittsburgh, USA with matched controls and 448 small families from Hungary.


RESULTS
Case-control and family-based analyses showed no association between COMD and any of the studied polymorphisms (all P values >0.05). Haplotype analysis of SLC6A4 was also negative in both samples.


CONCLUSIONS
Overall, the examination of genetic variants at the HTR1B, HTR2A, and SLC6A4 loci indicated no association between the selected polymorphisms and COMD.
Shaikh
Sajid A
SA
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.
Strauss
John
J
King
Nicole
N
Bulgin
Natalie L
NL
Vetró
Agnes
A
Kiss
Enikö
E
George
Charles J
CJ
Kovacs
Maria
M
Barr
Cathy L
CL
Kennedy
James L
JL
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D003866:Depressive Disorder / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D010290:Parents; D010414:Pennsylvania / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics* / Q000502:physiology; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D035781:Siblings
C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin