Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers.
Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and freeze-thaw stability. Electrostatic interaction between negatively charged model drug aspirin and positively charged co-polymer plays the most important role in drug loading and in vitro release studies. Drug release exhibited a biphasic profile with an initial burst release followed by a prolonged slow release, which could be potentially useful for target and controlled drug delivery.
Phanapavudhikul
Ponpan
P
Institute of Chemical and Engineering Sciences, Singapore.
Shen
Shoucang
S
Ng
Wai Kiong
WK
Tan
Reginald B H
RB
D000179:Acrylates / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002712:Chlorides / Q000737:chemistry; D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D005290:Ferric Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D012995:Solubility; D055672:Static Electricity; D013696:Temperature; D050337:Trimethyl Ammonium Compounds / Q000737:chemistry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000179:Acrylates; D002712:Chlorides; D003102:Colloids; D004337:Drug Carriers; D005290:Ferric Compounds; D007477:Ions; D010710:Phosphates; D011108:Polymers; D050337:Trimethyl Ammonium Compounds; D014867:Water; C000499:ferric oxide; D012965:Sodium Chloride; D001241:Aspirin