Comparative study of 5 different membranes for guided bone regeneration of rabbit mandibular defects beyond critical size.
BACKGROUND
Although several studies have examined use of collagen membranes in guided bone regeneration (GBR), none has examined the use of human fascia temporalis as a bioabsorbable barrier. The majority of studies related to GBR have examined critical size defects. We sought to assess the human fascia temporalis and other well-documented membranes applied for GBR in mandibular osseous defects beyond critical size.


METHODS
Fifty adult male New Zealand white rabbits were used in this study. Five groups of 10 animals each were used: HFL (human fascia lata membrane), HP (human pericardium), HFT (human fascia temporalis), BP (bovine pericardium), and PTFE (expanded polytetrafluoroethylene). Animals were killed 10 weeks after membrane application. In each animal, 9-mm circular mandibular defects were created bilaterally. On 1 side of the jaw, the defect was covered with 1 of the test membranes; the defect on the other side served as a control. Harvested specimens were examined histologically.


RESULTS
Membranes were significantly superior to the controls in all animals (P<0.001). Paired comparisons showed that groups HFL, HP, BP, and PTFE were significantly superior to HFT (P<0.05). Conversely, comparisons of HFL-HP, HFL-BP, HFL-PTFE, HP-BP, HP-PTFE, and BP-PTFE, showed no significant differences (P>0.05).


CONCLUSIONS
According to our results, the fascia temporalis is not recommended for GBR techniques. The fascia lata, human pericardium, bovine pericardium, and e-PTFE advance bone regeneration and can be successfully used as GBR membranes for osseous defects beyond the critical size.
Thomaidis
Vasilis
V
Clinic of Maxillofacial Surgery, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Kazakos
Kostas
K
Lyras
Dimitris N
DN
Dimitrakopoulos
Ioannis
I
Lazaridis
Nikolaos
N
Karakasis
Dimitrios
D
Botaitis
Sotirios
S
Agrogiannis
George
G
D000818:Animals; D001861:Bone Regeneration; D002417:Cattle; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000145:classification / Q000473:pathology* / Q000601:surgery*; D008566:Membranes / Q000637:transplantation; D011817:Rabbits