title: Prolonged refractory status epilepticus related to thrombotic thrombocytopenic purpura.
abstract: BACKGROUND
  Thrombotic thrombocytopenic purpura (TTP) is an extremely rare cause of status epilepticus. Review of literature demonstrated only four cases of brief status epilepticus (SE) associated with TTP.
  
  
  METHODS
  We describe a young woman with yet incomplete neurological recovery after prolonged refractory status epilepticus. Management required pentobarbital-induced coma for 60 days. Five months after onset, she was conversant and oriented with continued neuromuscular deficits.
  
  
  CONCLUSIONS
  This is an unusual presentation of severe refractory SE associated with TTP. With aggressive life support and prolonged pentobarbital infusion, however, survival and the chance of meaningful recovery appear to be possible.
authors: Department of Neurology, Division of Critical Care Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors: Alexander Y
authors: AY
authors: Zubkov
authors: Alejandro A
authors: AA
authors: Rabinstein
authors: Edward M
authors: EM
authors: Manno
authors: Eelco F M
authors: EF
authors: Wijdicks
mesh_terms: D000328:Adult; D004927:Escherichia coli Infections / Q000150:complications; D005260:Female; D005516:Food Microbiology; D006801:Humans; D011379:Prognosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D018805:Sepsis / Q000150:complications; D013226:Status Epilepticus / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013997:Time Factors