Gene regulation technologies in zebrafish.
Achieving the potential of zebrafish models in biomedical research is contingent on the development of reverse-genetic resources. This review describes current technologies for genetic perturbations in zebrafish, including an ecdysone receptor-based system that permits conditional transgene expression. Such methodologies promise to enable new zebrafish models for interrogating human physiology and disease.
Esengil
Hanife
H
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chen
James K
JK
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D005818:Genetic Engineering; D015027:Zebrafish / Q000235:genetics* / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
D029961:Zebrafish Proteins