title: The changing pattern of tuberculosis and HIV co-infection in immigrants and Spaniards in the last 20 years.
abstract: OBJECTIVE
  To evaluate the impact of immigration on tuberculosis (TB)-HIV co-infection in Spain in a prospective cohort of HIV patients.
  
  
  METHODS
  Among 7761 HIV patients, we evaluated 1284 with at least one episode of TB between 1987 and 2006. Variables were compared between immigrants and Spaniards.
  
  
  RESULTS
  Incidence of TB decreased from 20 to five cases per 100 patient-years in 2006 (P<0.01) and was always higher in immigrants than in Spaniards. The proportion of immigrants increased, reaching almost 50% of both new cases of HIV and TB-HIV co-infection in 2006. In 34.4% of patients, TB and HIV infection were diagnosed within the same year; simultaneous diagnosis was more frequent in immigrants (83.3%vs. 16.7%, P<0.001). Mortality was associated independently with age [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.01-1.05], TB diagnosis before 1996 (HR 2.6, 95% CI 1.8-3.6), use of highly active antiretroviral treatment (HR 0.494, 95% CI 0.37-0.66) and CD4 cell count at TB diagnosis (HR 0.996, 95% CI 0.995-0.997).
  
  
  CONCLUSIONS
  Immigrants have a major impact on the incidence of TB in HIV patients, slowing down the decreasing trend in Spain. Simultaneous diagnosis of the co-infection in immigrants reveals a need to intensify HIV case finding in immigrants in Spain.
authors: Fundación Hospital Alcorcón, Alcorcón, Madrid, Spain. mvelasco@fhalcorcon.es
authors: M
authors: M
authors: Velasco
authors: V
authors: V
authors: Castilla
authors: M
authors: M
authors: Cervero
authors: J
authors: J
authors: Sanz
authors: E
authors: E
authors: Condes
authors: G
authors: G
authors: Gaspar
authors: R
authors: R
authors: Torres
authors: A
authors: A
authors: Arranz
authors: C
authors: C
authors: Barros
authors: A
authors: A
authors: Monereo
mesh_terms: D000328:Adult; D000349:Africa / Q000208:ethnology; D000569:Americas / Q000208:ethnology; D001208:Asia / Q000208:ethnology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D054242:Emigrants and Immigrants; D005060:Europe / Q000208:ethnology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D009017:Morbidity / Q000639:trends; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology*; D044465:White People