title: 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.
abstract: 2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.
authors: Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. lalgudi.harikrishnan@bms.com
authors: Lalgudi S
authors: LS
authors: Harikrishnan
authors: Muthoni G
authors: MG
authors: Kamau
authors: Timothy F
authors: TF
authors: Herpin
authors: George C
authors: GC
authors: Morton
authors: Yalei
authors: Y
authors: Liu
authors: Christopher B
authors: CB
authors: Cooper
authors: Mark E
authors: ME
authors: Salvati
authors: Jennifer X
authors: JX
authors: Qiao
authors: Tammy C
authors: TC
authors: Wang
authors: Leonard P
authors: LP
authors: Adam
authors: David S
authors: DS
authors: Taylor
authors: Alice Ye A
authors: AY
authors: Chen
authors: Xiaohong
authors: X
authors: Yin
authors: Ramakrishna
authors: R
authors: Seethala
authors: Tara L
authors: TL
authors: Peterson
authors: David S
authors: DS
authors: Nirschl
authors: Arthur V
authors: AV
authors: Miller
authors: Carolyn A
authors: CA
authors: Weigelt
authors: Kingsley K
authors: KK
authors: Appiah
authors: Jonathan C
authors: JC
authors: O'Connell
authors: R
authors: R
authors: Michael Lawrence
mesh_terms: D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D001583:Benzoxazoles; D053480:Cholesterol Ester Transfer Proteins