Successful treatment of cepacia syndrome with combination nebulised and intravenous antibiotic therapy.
We report the case of successful treatment of a 31-year-old lady with cystic fibrosis and an en-bloc liver-pancreas transplant, who developed cepacia syndrome on a background of chronic infection with the ET12 epidemic strain of Burkholderia cenocepacia. Combination therapy with nebulised and intravenous meropenem and tobramycin led to clinical improvement with a return to baseline function and complete resolution of the acute chest X-ray changes.
Weidmann
A
A
Manchester Adult Cystic Fibrosis Centre, University Hospitals South Manchester NHS Trust, Wythenshawe, Manchester M23 9LT, UK.
Webb
A K
AK
Dodd
M E
ME
Jones
A M
AM
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019121:Burkholderia Infections / Q000188:drug therapy* / Q000382:microbiology; D016956:Burkholderia cepacia / Q000302:isolation & purification*; D003550:Cystic Fibrosis / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D000077731:Meropenem; D009330:Nebulizers and Vaporizers; D013577:Syndrome; D013845:Thienamycins / Q000008:administration & dosage; D014031:Tobramycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem; D014031:Tobramycin