Vanilloid receptor TRPV1, sensory C-fibers, and activation of adventitial mast cells. A novel mechanism involved in adventitial inflammation.
The immunological mechanisms on adventitial inflammation has received much attention, while the contribution of nerves to adventitial inflammation has largely been ignored. Although the mechanism of initial chemotaxis of the adventitial inflammatory cells remains unknown, vascular nerves were frequently found in the inflammatory lesions of coronary adventitia and adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries. The sensory nerves in contact with adventitial mast cells contained the neuropeptides SP and CGRP. These neuropeptides play an important role in the amplification of tissue injury by the increase of both vascular permeability and neutrophil recruitment, and the term ''neurogenic inflammation'' has been coined. Activation of adventitial mast cells, with ensuing release of vasoactive compounds, may cause vasoconstriction in atherosclerotic coronary segments. Therefore, we hypothesize that adventitial vanilloid receptor TRPV1 and sensory C-fibers may play a pistol role for adventitial inflammation.
Hu
Cheng Lin
CL
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. chenglinhu@yahoo.com
Xiang
Ji Zhou
JZ
Hu
Fei Fei
FF
D000818:Animals; D003238:Connective Tissue / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008407:Mast Cells / Q000502:physiology*; D008954:Models, Biological; D036421:Nerve Fibers, Unmyelinated / Q000502:physiology*; D020078:Neurogenic Inflammation / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013373:Substance P / Q000502:physiology; D050916:TRPV Cation Channels / Q000502:physiology*
D050916:TRPV Cation Channels; D013373:Substance P