Alpha-arylation of esters catalyzed by the Pd(I) dimer {[P(t-Bu)3]PdBr}2.
Conditions for the coupling of bromoarenes with esters using a single base and catalyst with improved turnover numbers are described. These general conditions were made possible by using the Pd(I) catalyst {[P(t-Bu)3]PdBr}2. Reactions of acetates, propionates, and isobutyrates are presented, and reactions of all three classes of esters on a 10 g scale are described.
Hama
Takuo
T
Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA.
Hartwig
John F
JF
D002384:Catalysis; D003500:Cyclization; D019281:Dimerization; D004952:Esters / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D004952:Esters; D010165:Palladium