title: Placental mesenchymal dysplasia associated with trisomy 13: sonographic findings.
abstract: Placental mesenchymal dysplasia (PMD) is a rare placental abnormality with sonographic and macroscopic features similar to those seen in a partial hydatidiform mole, and which has usually been reported with a normal female karyotype. We report a case of prenatally suspected PMD associated with trisomy 13. Sonography performed at 17 weeks' gestation showed multiple cystic spaces in the placenta resembling molar tissue, and a fetus with postaxial polydactyly and an atrial septal defect. An amniocentesis revealed a fetal karyotype of 46,XY,der(13), t(13;13)(q11;q11)[20]/47,XY,+13[11], consistent with trisomy 13. Cordocentesis confirmed the cytogenetic diagnosis. Histopathologic examination of the placenta following termination of the pregnancy at 22 weeks' gestation showed enlarged stem villi with loose connective tissue and cistern formation and no evidence of trophoblastic hyperplasia or stromal trophoblastic inclusions, which was consistent with PMD. PMD should be considered in the differential diagnoses of a placenta showing multiple cystic lesions on prenatal sonography, and karyotypic analysis should be performed.
authors: Unit of Perinatology, Department of Obstetrics and Gynecology,GATA Haydarpaş a Training Hospital, 34668, Usküdar, Istanbul, Turkey.
authors: Ercüment
authors: E
authors: Müngen
authors: Ozgür
authors: O
authors: Dundar
authors: Murat
authors: M
authors: Muhcu
authors: Aptullah
authors: A
authors: Haholu
authors: Yusuf
authors: Y
authors: Tunca
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000473:pathology; D000025:Abortion, Eugenic; D000028:Abortion, Induced; D000328:Adult; D000649:Amniocentesis; D002882:Chromosomes, Human, Pair 13; D017218:Cordocentesis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D010920:Placenta / Q000000981:diagnostic imaging / Q000473:pathology; D010922:Placenta Diseases / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D014314:Trisomy; D016216:Ultrasonography, Prenatal; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology