Daptomycin exerts bactericidal activity without lysis of Staphylococcus aureus.
The ability of daptomycin to produce bactericidal activity against Staphylococcus aureus while causing negligible cell lysis has been demonstrated using electron microscopy and the membrane integrity probes calcein and ToPro3. The formation of aberrant septa on the cell wall, suggestive of impairment of the cell division machinery, was also observed.
Cotroneo
Nicole
N
Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, MA 02421, USA.
Harris
Robert
R
Perlmutter
Nancy
N
Beveridge
Terry
T
Silverman
Jared A
JA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001433:Bacteriolysis / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D017576:Daptomycin / Q000494:pharmacology*; D005452:Fluoresceins; D005456:Fluorescent Dyes; D046529:Microscopy, Electron, Transmission; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D005452:Fluoresceins; D005456:Fluorescent Dyes; D017576:Daptomycin; C007740:fluorexon