Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test.
BACKGROUND
Coriander oil is used as an antimicrobial agent and as a natural fragrance. The present study investigated the anti-inflammatory potency of coriander oil in the ultraviolet (UV) erythema test in vivo.


METHODS
40 volunteers were enrolled in this monocentric,randomized,placebo-controlled double-blind study.Test areas on the back were irradiated with the 1.5 fold minimal erythema dose UV-B. Subsequently, the test areas were treated under occlusion for 47 hours with a lipolotion containing 0.5% or 1.0% essential coriander oil. Hydrocortisone (1.0%) and betamethasone valerate (0.1%) in the vehicle served as positive controls.The vehicle was used as place-bo.The effect of the test substances on the UV-induced erythema was measured photometrically after 48 hours.Additionally,the skin tolerance of the test preparations was assessed on non-irradiated skin.


RESULTS
Compared to placebo, the lipolotion with 0.5% coriander oil significantly reduced the UV-induced erythema, but it was not as effective as hydrocortisone. The skin tolerance of both coriander oil concentrations was excellent.


CONCLUSIONS
The lipolotion containing coriander oil displayed a mild antiinflammatory effect in this study. It could be useful in the concomitant treatment of inflammatory skin diseases.
Reuter
Juliane
J
Department of Dermatology, Competence Center Skintegral, University Medical Center Freiburg, Freiburg, Germany.
Huyke
Constance
C
Casetti
Federica
F
Theek
Carmen
C
Frank
Uwe
U
Augustin
Matthias
M
Schempp
Christoph
C
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D028526:Coriandrum / Q000737:chemistry*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D015990:Placebo Effect; D010936:Plant Extracts / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D016896:Treatment Outcome; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D009824:Ointments; D010936:Plant Extracts; D010938:Plant Oils