title: Adiponectin concentration and insulin indicators following overfeeding in identical twins.
abstract: Low adiponectin levels have been associated with high body mass index, low insulin sensitivity, and diabetes.
  
  
  OBJECTIVE
  To assess the relationships between changes in serum adiponectin concentration and adiposity, glucose, and insulin in response to long-term overfeeding in identical twins and to calculate the twin resemblance in serum adiponectin concentrations.
  
  
  METHODS
  Twenty-four sedentary young men [mean (+/-SD) age, 21+/-2 yr] who constituted 12 pairs of healthy identical twins were studied for metabolic and adiponectin changes in response to overfeeding.
  
  
  METHODS
  Subjects were overfed by 84,000 kcal over a 100-day period.
  
  
  METHODS
  The overfeeding study provides an opportunity to examine the relationships between adiponectin and changes in body weight, adiposity, plasma glucose and insulin.
  
  
  RESULTS
  Serum adiponectin concentration correlated positively with body weight (r= 0.41, p=0.05) at baseline but not with indicators of adiposity or with visceral fat. No relationship existed between baseline adiponectin concentration and body weight or adiposity gains with overfeeding. However, serum adiponectin decreased significantly by -2.35+/-0.48 microg/ml (p=0.001) in response to overfeeding. Baseline adiponectin levels correlated negatively with changes in plasma fasting glucose levels (r=-0.53, p=0.01) and homeostasis model assessment index (r=-0.41, p=0.05), independently of fat mass. The intrapair coefficient for twin resemblance (r=0.75, p=0.001) strongly suggests that baseline serum adiponectin concentration is a familial trait.
  
  
  CONCLUSIONS
  These data provide evidence that adiponectin concentration is a familial trait in normal-weight individuals, that it decreases when challenged by positive energy balance, and that its overfeeding-induced variations are correlated with glucose and insulin levels.
authors: Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
authors: O
authors: O
authors: Ukkola
authors: M
authors: M
authors: Terán-García
authors: A
authors: A
authors: Tremblay
authors: J-P
authors: JP
authors: Després
authors: C
authors: C
authors: Bouchard
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D044343:Overnutrition / Q000097:blood / Q000378:metabolism*; D014430:Twins, Monozygotic / Q000097:blood / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin