[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].
OBJECTIVE
Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and PON2-311 polymorphisms and their interaction on AMI risk.


METHODS
This case-control study involved 746 consecutive AMI patients and 1796 control subjects without cardiovascular disease, who were randomly selected from the same population from which the patients came. All participants were recruited between 1999 and 2000 from four Spanish autonomous regions. All were assessed for the presence of PON1-192 and PON2-311 and for classical cardiovascular risk factors. Multivariate analysis was carried out using logistic regression modeling.


RESULTS
The odds ratios (OR) of AMI for patients with the PON1-192 QQ and PON2-311 SS genotypes (who comprised 50% and 66% of the population, respectively) were 1.26 (95% confidence interval [CI], 1.02-1.55) and 1.25 (95% CI, 1.04-1.50), respectively, compared with R and C allele carriers. Moreover, in patients with both QQ and SS genotypes, the adjusted OR of AMI increased to 1.41 (95% CI, 1.13-1.76).


CONCLUSIONS
Our results indicate that the PON1-192 and PON2-311 polymorphisms were independent risk factors of AMI in our population.
Guxens
Mònica
M
Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, España.
Tomás
Marta
M
Elosua
Roberto
R
Aldasoro
Elena
E
Segura
Antonio
A
Fiol
Miquel
M
Sala
Joan
J
Vila
Joan
J
Fullana
Maria
M
Sentí
Mariano
M
Vega
Gema
G
de la Rica
Mónica
M
Marrugat
Jaume
J
D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human