title: Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan.
abstract: Ageing is associated with changes in physiology and morphology; nutritional strategies to decrease morbidity and to prolong life are of high interest. The aim of the study was to investigate the effects of lifelong supplementation with an oligofructose-enriched inulin on morphological and biological markers and lifespan in male and female rats. Male and female rats, age 3 months, were randomised into two groups to receive either a diet with 10 % of an oligofructose-enriched inulin (Synergy 1) or a standard diet (control) for 27 months. The rats were weighed every 2 weeks and their food intake was evaluated on four successive days every 4-6 weeks. Samples were taken at 12, 18 and 24 months of age. During the whole intervention period, male rats receiving Synergy 1 (SYN1-M) displayed lower body weight, cholesterol and plasma triacylglycerolaemia compared with the controls (Cont-M). The survival rate at 24 months of age of SYN1-M rats was 35.3 % greater than that of Cont-M rats. In female rats, the Synergy 1 supplementation (SYN1-F) group also reduced body weight, cholesterol and triacylglycerolaemia levels, but results were less consistent over the experiment. The survival rate at 24 months of age in SYN1-F rats was 33.3 % greater compared with that of the control (Cont-F) group. To conclude, lifelong intervention with Synergy 1 improved biological markers during ageing and survival rate (lifespan) of rats.
authors.affiliation: ETAP - Applied Ethology, 13 rue du Bois de la Champelle, F-54500 Vandoeuvre-lès-Nancy, France. email prozan@etap-lab.com
authors.forename: Pascale
authors.initials: P
authors.lastname: Rozan
authors.forename: Amine
authors.initials: A
authors.lastname: Nejdi
authors.forename: Sophie
authors.initials: S
authors.lastname: Hidalgo
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bisson
authors.forename: Didier
authors.initials: D
authors.lastname: Desor
authors.forename: Michaël
authors.initials: M
authors.lastname: Messaoudi
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004353:Drug Evaluation, Preclinical; D004435:Eating / Q000187:drug effects; D005260:Female; D007444:Inulin / Q000494:pharmacology*; D050356:Lipid Metabolism; D008136:Longevity / Q000187:drug effects; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D009844:Oligosaccharides; D014280:Triglycerides; C120489:oligofructose; D007444:Inulin; D002784:Cholesterol