title: Serum levels of PCDDs, PCDFs and PCBs in non-occupationally exposed population groups living near two incineration plants in Tuscany, Italy.
abstract: A pilot study was carried out in Tuscany, Italy, to provide preliminary information on the concentrations of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorobiphenyls (DL-PCBs), and selected non-dioxin-like PCBs (NDL-PCBs) in groups of subjects living in the vicinity of two incineration plants. Seventy-four volunteers were enrolled from areas identified as under a potential impact from incinerator emissions and from not exposed areas. No significant differences were observed between subjects living in the two types of areas. Total concentrations of PCDDs, PCDFs, and DL-PCBs resulted to be in the range 23-30 pg WHO-TEQ g(-1), lipid base, for subjects in the 27-54 year age groups, while concentrations increased to 40-44 pgTEQ g(-1) for the two 55-67 year age groups. The levels of PCDDs and PCDFs were in good agreement with those observed for unexposed population groups in Italy, while the contribution to total TEQ from DL-PCBs was appreciably higher than those currently observed in the general population in Italy and other countries. As to NDL-PCBs, serum levels of the six "indicator" congeners were in the range 240-300 ng g(-1), lipid base, for subjects in the 27-54 year age groups. A raise in NDL-PCB body burden (430-470 ng g(-1), lipid base) was observed for the two 55+ year age groups, in agreement with the expected age-dependent increase. The findings from this study do not show an incremental exposure to PCDDs and PCDFs in the samples from subjects living around the two incineration plants, whereas PCB congener profiles in all samples suggest a possible impact on the area of interest of industrial activities from near industrial settlements.
authors.affiliation: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy. defelip@iss.it
authors.forename: Elena
authors.initials: E
authors.lastname: De Felip
authors.forename: Annalisa
authors.initials: A
authors.lastname: Abballe
authors.forename: Francesco
authors.initials: F
authors.lastname: Casalino
authors.forename: Alessandro
authors.initials: A
authors.lastname: di Domenico
authors.forename: Pierangela
authors.initials: P
authors.lastname: Domenici
authors.forename: Nicola
authors.initials: N
authors.lastname: Iacovella
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ingelido
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pretolani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Spagnesi
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000097:blood*; D006801:Humans; D017745:Incineration; D007558:Italy; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000097:blood*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood; D011108:Polymers
chemical_list: D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran; D011078:Polychlorinated Biphenyls