title: Use of the ADOS and ADI-R in children with psychosis: importance of clinical judgment.
abstract: The Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview - Revised (ADI-R) are considered to be the 'gold standard' in diagnostic evaluations for autism. Developed as research tools and now gaining wide clinical use, the ADOS/ADI-R assessment package has been demonstrated to differentiate children with autism from those with other developmental disabilities; however, little work concerning the reliability and validity of the tools in children with a known history of psychosis has been undertaken. We report on the administration of the ADOS, ADI-R and clinical judgment in three cases of Childhood-Onset Schizophrenia. All 3 children met both ADOS and ADI-R criteria for an autism spectrum diagnosis, even though none of them received a clinical diagnosis of autism from either a research child psychiatrist or an experienced clinically trained, research psychologist with expertise in autism. Issues concerning overlap of symptom presentation and implications for research and clinical use of these assessment tools are discussed.
authors.affiliation: Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora 80045, USA. judy.reaven@uchsc.edu
authors.forename: Judith A
authors.initials: JA
authors.lastname: Reaven
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hepburn
authors.forename: Randal G
authors.initials: RG
authors.lastname: Ross
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D002648:Child; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D002658:Developmental Disabilities / Q000175:diagnosis / Q000523:psychology; D003937:Diagnosis, Differential; D005820:Genetic Testing; D006212:Hallucinations / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics; D012565:Schizophrenic Psychology