Relation of bone mineral density to frequency of coronary heart disease.
Coronary angiography was performed because of chest pain in 198 patients (146 women, 52 men; mean age 66 years) who had dual-energy x-ray absorptiometry scans of the spine and left hip because of suspected osteoporosis or osteopenia. Of the 198 patients, 53 (27%) had osteoporosis, 79 (40%) had osteopenia, and 66 (33%) had normal bone mineral density (BMD). Obstructive coronary artery disease with >50% narrowing of > or =1 major coronary artery was present in 40 of 53 patients (76%) with osteoporosis, in 54 of 79 patients (68%) with osteopenia, and in 31 of 66 patients (47%) with normal BMD (p <0.005 comparing osteoporosis with normal BMD, p <0.01 comparing osteopenia with normal BMD). In conclusion, in patients who undergo coronary angiography because of chest pain, patients with osteoporosis or osteopenia have a higher prevalence of obstructive coronary artery disease than those with normal BMD.
Varma
Raja
R
Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York, USA.
Aronow
Wilbert S
WS
Basis
Yana
Y
Singh
Tarundit
T
Kalapatapu
Kumar
K
Weiss
Melvin B
MB
Pucillo
Anthony L
AL
Monsen
Craig E
CE
D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications* / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications* / Q000000981:diagnostic imaging; D012189:Retrospective Studies