[Relationship between cardiovascular complication and inflammation, oxidative stress of patient with maintenance hemodialysis].
OBJECTIVE
To evaluate and analyze relationships between states of inflammation, oxidative stress and complicatedly cardiovascular diseases in patients with maintenance hemodialysis (MHD).


METHODS
The analytical method for xanthine oxidase was used to measure the serum superoxide dismutase (SOD), spectrophotometry was used to measure the serum MDA, GSHPx. The immune turbidimetry was used to measure the serum levels of C-reactive protein (CRP) in patients with chronic renal failure.


RESULTS
Compared with normal control group, the uremia groups had lower serum GSHPx, SOD and ALB levels, but higher CRP and MDA levels (P < 0.01). The MHD patients exhibited more serious disturbance of inflammation and oxidative stress which were aggravated as MHD time extended. CRP and MDA were significantly increased but GSHPx,SOD and ALB decreased in patients with cardiovascular events compared with the patients without them (P < 0.01). The results of Pearson correlation analysis showed: CRP was correlated with MDA positively (r = 0.740, P < 0.01), while with GSHPx, SOD, ALB negatively (r = -0.684, -0.688, -0.924, P < 0.01). ALB was correlated with GSHPx, SOD positively (r = 0.744, 0.728, P < 0.01), while with MDA negatively (r = -0 779, P < 0.01). The results of Logistic regression analysis showed that CRP contributed to the predictability of incidence of CVD (regression coefficient b = -1.054, Wald chi-square = 5.251, OR = 0.348, P < 0.05).


CONCLUSIONS
MHD patients are in the states of inflammation and oxidative stress which are aggravated with the prolonging of hemodialysis time. Inflammation and oxidative stress may be the risk factors for occurrence of cardiovascular events.
Zuo
Chuan
C
Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China.
Qiu
Hong-yu
HY
Li
Zi
Z
Xie
Xi-sheng
XS
Fan
Jun-ming
JM
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000150:complications*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood
D008315:Malondialdehyde; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase