title: Electrokinetic probes for single-step screening of polyol stereoisomers: the virtues of ternary boronate ester complex formation.
abstract: Electrokinetic probes based on the differential migration of ternary boronate ester complexes permit the selective analysis of micromolar levels of UV-transparent polyol stereoisomers in urine samples via dynamic complexation-capillary electrophoresis that is applicable to single-step screening of in-born errors of sugar metabolism, such as galactosemia.
authors.affiliation: Department of Chemistry, McMaster University, Hamilton, ON, L8S 4M1, Canada.
authors.forename: Claire
authors.initials: C
authors.lastname: Kaiser
authors.forename: Giselle
authors.initials: G
authors.lastname: Segui-Lines
authors.forename: Jason C
authors.initials: JC
authors.lastname: D'Amaral
authors.forename: Adam S
authors.initials: AS
authors.lastname: Ptolemy
authors.forename: Philip
authors.initials: P
authors.lastname: Britz-McKibbin
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002021:Buffers; D004563:Electrochemistry; D019075:Electrophoresis, Capillary; D005693:Galactosemias / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D015335:Molecular Probes / Q000737:chemistry*; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013402:Sugar Alcohols / Q000652:urine*
chemical_list: D001897:Boronic Acids; D002021:Buffers; D015335:Molecular Probes; D013402:Sugar Alcohols; C017562:3-nitrobenzeneboronic acid