title: Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia.
abstract: The authors performed a three-dimensional shape deformation analysis to clarify the various patterns of specific thalamic nuclei abnormality using three age-matched and sex-matched groups of 22 patients with obsessive-compulsive disorder (OCD), 22 patients with schizophrenia and 22 control participants. Compared with the healthy volunteers, the anterior, lateral outward surface deformities of the thalamus were significant in OCD patients, whereas the posterior, medial outward deformities of the thalamus were prominent in schizophrenia patients. In terms of thalamic asymmetry, both OCD and schizophrenia patients exhibited the loss of a leftward pattern of asymmetry on the posterior, medial surface of the thalamus. Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Do-Hyung
authors.initials: DH
authors.lastname: Kang
authors.forename: Sun Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Chi-Won
authors.initials: CW
authors.lastname: Kim
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Choi
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Jang
authors.forename: Myung Hun
authors.initials: MH
authors.lastname: Jung
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000473:pathology*; D012559:Schizophrenia / Q000473:pathology*; D013788:Thalamus / Q000473:pathology*