title: Oral iron chelators.
abstract: Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes. A chelator's efficacy at cardiac and liver iron removal and side-effect profile should be considered when tailoring individual chelation regimens. Broader options for chelation therapy, including possible combination therapy, should improve clinical efficacy and enhance patient care.
authors.affiliation: University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. kwiatkowski@email.chop.edu
authors.forename: Janet L
authors.initials: JL
authors.lastname: Kwiatkowski
mesh_terms: D000284:Administration, Oral; D001565:Benzoates / Q000008:administration & dosage; D002614:Chelating Agents / Q000008:administration & dosage*; D002648:Child; D000077588:Deferasirox; D000077543:Deferiprone; D003676:Deferoxamine / Q000008:administration & dosage; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D006801:Humans; D019190:Iron Overload / Q000188:drug therapy* / Q000209:etiology; D011728:Pyridones / Q000008:administration & dosage; D017262:Siderophores / Q000008:administration & dosage*; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D001565:Benzoates; D002614:Chelating Agents; D011728:Pyridones; D017262:Siderophores; D014230:Triazoles; D000077543:Deferiprone; D003676:Deferoxamine; D000077588:Deferasirox