title: Angina bullosa hemorrhagica of the soft palate: a clinical study of 16 cases.
abstract: Angina bullosa hemorrhagica (ABH) is an oral mucosal blood blister that develops without blood dyscrasia or vesiculobullous disorder. Although a minor mucosal trauma has been suggested as a triggering factor for ABH, its etiopathogenesis, especially the causative role of systemic conditions, is largely unknown. We investigated the presence or absence of local factors as well as systemic background disease in 16 patients with ABH arising in the soft palate. All the lesions were solitary, and 75% of them (n = 12) appeared during the ingestion of hard or crispy food. With regard to underlying systemic conditions, hypertension was the most common (n = 6), and asthma, insomnia, diabetes mellitus, rheumatoid arthritis, gastrointestinal disorder and hyperuricemia were also recorded (n = 1 each). Five patients had no significant background disease. There were no recalcitrant or recurrent cases. In conclusion, the present study has revealed that scratching of the oral mucosa during eating plays an important role in the formation of ABH. Hypertension appears to be the most frequent background condition, but its pathogenic relationship with ABH remains speculative, as hypertension is fairly common in adults.
authors.affiliation: Department of Oral Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan. horien@saitama-med.ac.jp
authors.forename: Norio
authors.initials: N
authors.lastname: Horie
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kawano
authors.forename: Junichi
authors.initials: J
authors.lastname: Inaba
authors.forename: Takehiro
authors.initials: T
authors.lastname: Numa
authors.forename: Takao
authors.initials: T
authors.lastname: Kato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nasu
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kaneko
authors.forename: Itsuro
authors.initials: I
authors.lastname: Kudo
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimoyama
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications; D001249:Asthma / Q000150:complications; D001768:Blister / Q000209:etiology*; D048909:Diabetes Complications; D005260:Female; D005502:Food; D005767:Gastrointestinal Diseases / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D033461:Hyperuricemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology*; D009061:Mouth Mucosa / Q000293:injuries; D006472:Oral Hemorrhage / Q000209:etiology*; D010160:Palate, Soft / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications