Effect of antenatal hypoxia on age-specific dynamics of ECG parameters and content of biogenic amines in the central nervous system.
We studied the effect of acute antenatal hypoxia during the stages of progestation and early organogenesis on some ECG parameters and level of biogenic amines in brain structures in rats. The effect of acute hypoxic exposure during the organogenesis period on the studied parameters was more pronounced than the effect of acute hypoxic exposure during the progestation period. The shift of the autonomic balance towards the sympathetic regulation of cardiac activity is linked with increased content of biogenic amines in the brain stem and cortical structures.
Graf
A V
AV
Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University. stasy_gr@pochta.ru
Maslova
M V
MV
Trofimova
L K
LK
Dunaeva
T Yu
TY
Sokolova
N A
NA
Kudryashova
N Yu
NY
Krushinskaya
Ya V
YV
Goncharenko
E N
EN
D000367:Age Factors; D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D001679:Biogenic Amines / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D005311:Fetal Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine