title: Effects of antacid therapy in asymptomatic patients with presence of amoeba in stool report.
abstract: Amoebic infection caused by the protozoan parasite Entamoeba histolytica is a prevalent infection in the developing countries. Milder form of this infection is associated with loose stool, flatulence and borborygmi, may or may not be associated with pain in abdomen and treated symptomatically by some physicians by antacid. To find out the effects of antacid (sorbacid) therapy in patients with amoeba in stools by examining the changes in the stool report, a study was conducted among 25 patients enrolled in the study with complaints of "gas" in the abdomen with stool reports positive for amoeba. Antacid (sorbacid) in a dose of one teaspoonful (5 ml) was given three times a day for 3 days and stool examination was repeated. The report showed a significant reduction in the amoeba and mucus in stool (p<0.05) and a trend towards reduction in the presence of occult blood. Other parameters in stool reports did not change. Moreover, all the patients gave the history of passing formed stools and no complaints of "gas" in abdomen thus providing the symptomatic benefit. Antacids may have some beneficial effects in amoebiasis. More studies are required to confirm the above finding and to find out the place of antacid as an adjuvant therapy along with the standard anti-amoebic drugs.
authors.affiliation: Alkem Laboratories Limited, Mumbai.
authors.forename: Jaisen
authors.initials: J
authors.lastname: Lokhande
authors.forename: Dhurandhar
authors.initials: D
authors.lastname: Katke
authors.forename: K P
authors.initials: KP
authors.lastname: Kulkarni
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy; D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D003906:Developing Countries; D004748:Entamoeba histolytica / Q000187:drug effects / Q000302:isolation & purification*; D004749:Entamoebiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D006801:Humans; D011446:Prospective Studies
chemical_list: D000863:Antacids