Vitiligoid lichen sclerosus: a reappraisal.
BACKGROUND
Many case studies of lichen sclerosus (LS) have reported an association of vitiligo. However, such an association is not reported from larger case studies of vitiligo, which happens to be a common disease. Autoimmune etiology suspected in both LS and vitiligo has been considered as the reason for their association in some patients. It has also been suggested that lichenoid inflammation in LS may trigger an autoimmune reaction against melanocytes.


OBJECTIVE
To test this association, we reviewed clinical and histological features of 266 cases of vitiligo and 74 cases of LS in a concurrent study of both diseases.


METHODS
All outpatients seen in our department between 2003 and 2006 and who were diagnosed as having LS or vitiligo on the basis of clinical and pathologic features were included in the study.


RESULTS
Vitiligoid lesions were seen along with stereotypical LS lesions in three patients but all the three lesions had histological features of LS. Oral/genital areas were affected in 57 out of the 74 LS cases and of those, 15 were initially suspected to have vitiligo. These cases with a clinical appearance of vitiligo and histological features of LS were considered as 'vitiligoid LS', a superficial variant proposed by J. M. Borda in 1968. Association of LS was not observed in the 266 cases of vitiligo.


CONCLUSIONS
Exclusive oral/genital depigmentation is a common problem and histological evaluation is essential to differentiate vitiligoid LS from true vitiligo. The association of vitiligo with LS may have been documented due to the clinical misdiagnosis of vitiligoid LS lesions as vitiligo as histological investigations were not undertaken in any of the reported cases.
Attili
Venkat Ratnam
VR
Visakha Institute of Skin and Allergy, Visakhapatnam, Andhra Pradesh, India. vrattili@hotmail.com
Attili
Sasi Kiran
SK
D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology; D014820:Vitiligo / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology