Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia.
The authors performed a three-dimensional shape deformation analysis to clarify the various patterns of specific thalamic nuclei abnormality using three age-matched and sex-matched groups of 22 patients with obsessive-compulsive disorder (OCD), 22 patients with schizophrenia and 22 control participants. Compared with the healthy volunteers, the anterior, lateral outward surface deformities of the thalamus were significant in OCD patients, whereas the posterior, medial outward deformities of the thalamus were prominent in schizophrenia patients. In terms of thalamic asymmetry, both OCD and schizophrenia patients exhibited the loss of a leftward pattern of asymmetry on the posterior, medial surface of the thalamus. Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia.
Kang
Do-Hyung
DH
Department of Psychiatry, Seoul National University College of Medicine, Hanyang University, Seoul, Korea.
Kim
Sun Hyung
SH
Kim
Chi-Won
CW
Choi
Jung-Seok
JS
Jang
Joon Hwan
JH
Jung
Myung Hun
MH
Lee
Jong-Min
JM
Kim
Sun I
SI
Kwon
Jun Soo
JS
D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000473:pathology*; D012559:Schizophrenia / Q000473:pathology*; D013788:Thalamus / Q000473:pathology*