title: Two new cytotoxic pregnane glycosides from Cynanchum auriculatum.
abstract: Two new pregnane glycosides, kidjoranin 3- O- alpha-diginopyranosyl-(1-->4)- beta-cymaropyranoside (1) and kidjoranin 3-O-beta-digitoxopyranoside (2), together with one known compound caudatin 3 -O-beta-cymaropyranoside (3), were isolated from the roots of Cynanchum auriculatum. Their structures were established on the basis of NMR analyses. Compounds 1 - 3 were tested for their in vitro inhibitory activity against the growth of human tumor cell lines SMMC-7721, HeLa and MCF7; all of them displayed marked cytotoxic activities against cells SMMC-7721 and HeLa with IC (50) values ranging from 8.6 microM to 58.5 microM, yet no activity against the cell line MCF7 was detected.
authors.affiliation: Department of Natural Product Chemistry, Jiangsu Provincial Institute of Traditional Chinese Medicine, Shizi Street 100, Hongshan Road, Nanjing, P. R. China. liyoubinli@sohu.com
authors.forename: Youbin
authors.initials: Y
authors.lastname: Li
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Gu
authors.forename: Yunru
authors.initials: Y
authors.lastname: Peng
authors.forename: Weihua
authors.initials: W
authors.lastname: Huang
authors.forename: Shihui
authors.initials: S
authors.lastname: Qian
mesh_terms: D045744:Cell Line, Tumor; D031105:Cynanchum / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D003603:Cytotoxins; D006027:Glycosides; D011278:Pregnanes