title: Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.
authors.affiliation: Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1, 08028 Barcelona, Spain.
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Faham
authors.forename: Mercedes
authors.initials: M
authors.lastname: Armand-Ugón
authors.forename: Jose A
authors.initials: JA
authors.lastname: Esté
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001583:Benzoxazoles / Q000737:chemistry / Q000494:pharmacology; D002219:Carbamates / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016333:HIV Protease / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000821:virology; D008745:Methylation; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D001583:Benzoxazoles; D002219:Carbamates; D017320:HIV Protease Inhibitors; D010879:Piperazines; D000077489:Piperazine; D014508:Urea; D016333:HIV Protease