Molecular control of meiosis.
The animal cell cycle consists of a round of chromosomal DNA replication in S-phase, followed by segregation of the replicated chromosomes into the daughter nuclei during M-phase. In most animal cells, gap phases termed G(1) and G(2) are introduced between the M- and S-phases, respectively. Meiosis is a particular example of cell division occurring in germ cells. This specialized cell cycle consists of two successive rounds of chromosome segregation that follow a round of DNA replication. Meiosis produces progeny cells with half as many chromosomes as their parents, thus making sexual reproduction possible. This review is concerned with the factors that have been implicated in the control of meiosis, although research in progress may reveal additional regulatory processes.
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The Department of Hormone Research, The Weizmann Institute of Science, Rehovot, Israel.