title: Synthesis and cytotoxicity of a salicylihalamide A analogue.
abstract: The synthesis of a simple analogue of salicylihalamide A with a truncated lactone ring (+/- 2) was achieved in 10 steps. Its cytotoxicity profile in the NCI 60-cell-line human tumor assay differed significantly from that of salicylihalamide A in both level and specificity.
authors.affiliation: Gustaf H Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
authors.forename: Shaoshan
authors.initials: S
authors.lastname: Tang
authors.forename: Karen L
authors.initials: KL
authors.lastname: Erickson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; C410986:salicylihalamide A