[FISH technique in aneuplodies prenatal diagnosis].
Chromosomal disorders are severe and affect 0.9% of the newborns. In these conditions, prenatal diagnosis should be compulsory in every public medical system.


METHODS
Our study is a retrospective analysis of pregnant women investigated by amniocentesis and FISH technique.


RESULTS
We analyzed 233 samples collected between 2004 and 2007 at Iaşi "Cuza-Vodă" Obstetrics and Gynecology Hospital. The majority of cases were investigated between 16 and 24 weeks of pregnancy. Thirty-eight abnormal cases (16.30%) were identified: 17 cases with 21 trisomy, 16 cases with 18 trisomy, 3 cases with X monosomy, and 2 cases with 13 trisomy. The main reasons for amniocentesis were: advanced maternal age (12.5% abnormal cases) ultrasound abnormalities (26.15% abnormal cases), and biochemical abnormalities (7.14% abnormal cases).


CONCLUSIONS
Our data are in agreement with other studies, and support our results.
Gorduza
E V
EV
Disciplina de Genetică Medicală, Universitatea de Medicină si Farmacie "Gr.T. Popa", Iaşi.
Onofriescu
M
M
Martiniuc
Violeta
V
Grigore
Mihaela
M
Mihălceanu
Elena
E
Iliev
Gh
G
D000649:Amniocentesis; D000782:Aneuploidy; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000235:genetics; D020732:Cytogenetic Analysis; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal