Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma.
OBJECTIVE
To evaluate the associations between diet and non-Hodgkin lymphoma (NHL) according to t(14;18) status, one of the most common chromosomal abnormalities in NHL, as t(14;18)-positive NHL represents a genetically more homogeneous group than NHL overall.


METHODS
We determined the presence of the t(14;18)(q32;q21) by fluorescence in situ hybridization in 172 of 175 tumor blocks from a population-based, case-control study conducted in Nebraska during 1983-1986. Information on the frequency of consumption as an adult of 30 food items was derived from the parent case-control study. Dietary factors in 60 t(14;18)-positive and 87 t(14;18)-negative cases were compared with 1,075 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using polytomous logistic regression.


RESULTS
The risk of t(14;18)-positive NHL for the highest versus the lowest approximate tertile of intake was elevated for milk (OR = 2.2; 1.0-5.0) and dietary nitrite (OR = 2.8; 1.3-6.1), whereas coffee consumption was inversely associated with risk (OR = 0.4; 0.2-0.7). We also found inverse associations between the intake of fish (OR = 0.5; 0.3-1.0) and carotene (OR = 0.5; 0.2-0.9) and risk of t(14;18)-negative NHL. There was no association between the intake of meats, vegetables, protein, or vitamin C and risk of either t(14;18)-positive or t(14;18)-negative NHL.


CONCLUSIONS
We observed differences in associations between diet and t(14;18)-defined subgroups of NHL. These findings should be interpreted cautiously because of the small sample.
Chiu
Brian C-H
BC
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611-4402, USA. bchiu@northwestern.edu
Dave
Bhavana J
BJ
Ward
Mary H
MH
Fought
Angela J
AJ
Hou
Lifang
L
Jain
Smrati
S
Gapstur
Susan
S
Evens
Andrew M
AM
Zahm
Shelia Hoar
SH
Blair
Aaron
A
Weisenburger
Dennis D
DD
D016022:Case-Control Studies; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D004032:Diet; D002149:Energy Intake; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D009329:Nebraska / Q000453:epidemiology; D012307:Risk Factors; D014178:Translocation, Genetic / Q000235:genetics*