title: Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography.
abstract: We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (18F-FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA. skonecky@physics.upenn.edu
authors.forename: Soren D
authors.initials: SD
authors.lastname: Konecky
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Alper
authors.initials: A
authors.lastname: Corlu
authors.forename: Kijoon
authors.initials: K
authors.lastname: Lee
authors.forename: Rony
authors.initials: R
authors.lastname: Wiener
authors.forename: Shyam M
authors.initials: SM
authors.lastname: Srinivas
authors.forename: Janet R
authors.initials: JR
authors.lastname: Saffer
authors.forename: Richard
authors.initials: R
authors.lastname: Freifelder
authors.forename: Joel S
authors.initials: JS
authors.lastname: Karp
authors.forename: Nassim
authors.initials: N
authors.lastname: Hajjioui
authors.forename: Fred
authors.initials: F
authors.lastname: Azar
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D001940:Breast / Q000000981:diagnostic imaging* / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*