title: Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells.
abstract: A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (-)-ampelopsin A (2), (-)-alpha-viniferin (3), ampelopsin E (4), (-)-vaticanol B (5), and (-)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.
authors.affiliation: Natural Products Research Group, Department of Chemistry, Bandung Institute of Technology, Jalan Ganeca 10, Bandung, 40132, Indonesia.
authors.forename: Haryoto
authors.initials: H
authors.lastname: Saroyobudiono
authors.forename: Lia D
authors.initials: LD
authors.lastname: Juliawaty
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
authors.forename: Sjamsul A
authors.initials: SA
authors.lastname: Achmad
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.forename: Jalifah
authors.initials: J
authors.lastname: Latip
authors.forename: Ikram M
authors.initials: IM
authors.lastname: Said
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D053958:Dipterocarpaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013267:Stilbenes