GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
GABA (gamma-aminobutyric acid) type A receptors (GABA(A)Rs) mediate most fast synaptic inhibition in the mammalian brain, controlling activity at both the network and the cellular levels. The diverse functions of GABA in the CNS are matched not just by the heterogeneity of GABA(A)Rs, but also by the complex trafficking mechanisms and protein-protein interactions that generate and maintain an appropriate receptor cell-surface localization. In this Review, we discuss recent progress in our understanding of the dynamic regulation of GABA(A)R composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations. Finally, we highlight a number of neurological disorders, including epilepsy and schizophrenia, in which alterations in GABA(A)R trafficking occur.
Jacob
Tija C
TC
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Moss
Stephen J
SJ
Jurd
Rachel
R
D000818:Animals; D004827:Epilepsy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D011963:Receptors, GABA-A / Q000378:metabolism*; D013569:Synapses / Q000502:physiology
D011963:Receptors, GABA-A