Stereoselective synthesis of (+)-polyoxamic acid based on the synthesis of chiral oxazine.
A concise, stereocontrolled synthesis of (+)-polyoxamic acid was achieved. Starting from trans-oxazoline as a chiral building block, the key step involves diastereoselective oxazine formation catalyzed by palladium(0).
Joo
Jae-Eun
JE
College of Pharmacy, SungKyunKwan University, Suwon, 440-746, Korea.
Pham
Van-Thoai
VT
Tian
Yong-Shou
YS
Chung
Yun-Sung
YS
Oh
Chang-Young
CY
Lee
Kee-Young
KY
Ham
Won-Hun
WH
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013400:Sugar Acids / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D010078:Oxazines; D013400:Sugar Acids; C529752:polyoxamic acid