title: [Mortality from pleural and peritoneal cancer in a cohort of asbestos workers, many years after start of the exposure: possible role of fibers clearance].
abstract: The multistage theory of carcinogenesis assumes rates of mesothelioma increasing monotonically as a function of time since first exposure (TSFE) to asbestos. However, some authors have suggested that the increase in mesothelioma rate with TSFE might be attenuated by clearance of asbestos from the lungs. We estimated mortality time trends from pleural and peritoneal cancer in a cohort of 3443 asbestos-cement workers. The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalized to include a term representing elimination over time. We observed 139 deaths from pleural and 56 from peritoneal cancer during the period 1950-2003. The rate of pleural cancer increased during the first 40 years of TSFE and reached a plateau thereafter. In contrast, the rate of peritoneal cancer increased monotonically with TSFE. The model allowing for asbestos elimination fitted the data better than the traditional model for pleural (p = 0.02) but not for peritoneal cancer (p = 0.22). The risk for pleural cancer, rather than showing an indefinite increase, might reach a plateau when a sufficiently long time has elapsed since exposure. The different trends for pleural and peritoneal cancer might be related to clearance of the asbestos from the workers' lungs.
authors.affiliation: SCDU Epidemiologia dei Tumori, Università di Torino, Via Santena 7, 10126, Torino, Italia. fbaroneadesi@yahoo.it
authors.forename: F Barone
authors.initials: FB
authors.lastname: Adesi
authors.forename: D
authors.initials: D
authors.lastname: Ferrante
authors.forename: M
authors.initials: M
authors.lastname: Bertolotti
authors.forename: A
authors.initials: A
authors.lastname: Todesco
authors.forename: D
authors.initials: D
authors.lastname: Mirabelli
authors.forename: B
authors.initials: B
authors.lastname: Terracini
authors.forename: C
authors.initials: C
authors.lastname: Magnani
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D019016:Mineral Fibers / Q000009:adverse effects*; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D010534:Peritoneal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality*; D010997:Pleural Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality*; D013997:Time Factors
chemical_list: D019016:Mineral Fibers; D001194:Asbestos