Ir-catalyzed regio- and enantioselective Friedel-Crafts-type allylic alkylation of indoles.
Highly regio- and enantioselective Ir-catalyzed Friedel-Crafts type allylic alkylation of indoles have been realized using [Ir(COD)Cl]2/phosphoramidite ligand 1a, affording the branched products with up to >97/3 branched-linear ratio and 92% ee.
Liu
Wen-Bo
WB
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
He
Hu
H
Dai
Li-Xin
LX
You
Shu-Li
SL
D000478:Alkylation; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007495:Iridium / Q000737:chemistry
D007211:Indoles; D007495:Iridium