title: [Clinical manifestations, complications and treatment of brucellosis: 45-patient study].
abstract: The aim of this study was to evaluate the clinical, laboratory findings and therapeutic features of patients with brucellosis. The diagnosis was made by clinical findings, automated blood culture, serology (Rose Bengal plate agglutination test, standard tube agglutination (Wright) and immunofluorerescence). The susceptibility of 13 strains was tested in vitro. The base sequence was determined for four strains. Forty-five cases were collected (31 acute and 14 sub-acute). Contamination was digestive in 62%. Symptoms of patients were fever (93%), sweating (82%), arthralgia (78%) and splenomegaly (51%). Elevated erythrocyte sedimentation rate was determined in 80%, leukopenia in 49% and anaemia in 37% of cases. Blood cultures were positives in 39% of cases. The four sequenced strains were identified as Brucella melitensis biovar abortus. Six strains were resistant to sufomethoxazol-trimetoprim (54%). In 93% of cases, the treatment was associated rifampicin and doxycyclin. One patient died. No relapse was reported.
authors.affiliation: Laboratoire de microbiologie, hôpital la Rabota, rue Jabbari, 1007 Tunis, Tunisie. m.zribi@tunet.tn
authors.forename: M
authors.initials: M
authors.lastname: Zribi
authors.forename: L
authors.initials: L
authors.lastname: Ammari
authors.forename: A
authors.initials: A
authors.lastname: Masmoudi
authors.forename: H
authors.initials: H
authors.lastname: Tiouiri
authors.forename: C
authors.initials: C
authors.lastname: Fendri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000209:etiology; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D002003:Brucella abortus / Q000187:drug effects / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D003611:Dairy Products / Q000009:adverse effects / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005516:Food Microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D021521:Ribotyping; D013163:Splenomegaly / Q000209:etiology; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents