Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri.
The synthesis of (+/-)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied against Candida albicans (14053 and ATCC 10231), Candida inconspicua, Candida dubliniensis and Candida krusei.
Kenéz
Agnes
A
Department of Organic Chemistry, University of Debrecen, Hungary.
Lestár
Zsombor
Z
Lenkey
Béla
B
Antus
Sándor
S
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005779:Immunodiffusion; D009682:Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D044950:Flavanones