[Modified FOLFOX6 in a patient on hemodialysis with metastatic colorectal cancer].
Since pharmacokinetics in patients undergoing hemodialysis differs from that in patients with normal renal function, chemotherapy for a hemodialysis patient should be considered with due care. We administered chemotherapy of modified FOLFOX6 to a patient on hemodialysis with inoperable metastatic colorectal cancer, and measured his plasma concentration of total platinum and non-protein-bound platinum. Since there is no reported case of oxaliplatin use in patients on hemodialysis so far, we evaluated whether it could be safely used for such patients. We made a dose escalation study with 40, 50, 60, 70 and 85 mg of oxaliplatin, and evaluated the pharmacokinetics at each dose. AUC was 5.67-10.21 mg/L x h. The dialysis removal rate was 84.0%. Although this patient could accept it relatively safely without any severe side effect, the optimal dosage and the timing of hemodialysis for inoperable metastatic colorectal cancer patients should be determined by a further study using more cases.
Matoba
Shuichiro
S
Department of Gastroenterological Surgery, Toranomon Hospital.
Sawada
Toshihito
T
Toda
Shigeo
S
Moriyama
Jin
J
Yokoyama
Tsuyoshi
T
Ehara
Kazuhisa
K
Mine
Shinji
S
Ueno
Masaki
M
Kinoshita
Yoshihiro
Y
Matsuda
Masamichi
M
Tsutsumi
Kenji
K
Hashimoto
Masaji
M
Udagawa
Harushi
H
Watanabe
Goro
G
Katori
Hideyuki
H
Hayashi
Masahiro
M
Igarashi
Masahiro
M
Ito
Tadaaki
T
Hasebe
Shinobu
S
Sato
Mayumi
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009401:Nephrosis / Q000150:complications / Q000628:therapy*; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D006435:Renal Dialysis
D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil