Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines.
A direct solid-phase synthesis of a series of substituted benzimidazole-containing peptides is described. The method involves on-resin formation of new amino acids containing benzimidazole derivatives in the side chain. The heterocycle conjugates were obtained by reaction between aldehydes and peptides containing beta-(3,4-diaminophenyl)alanine residue, immobilized on a polymeric solid support.
Koprowska-Ratajska
Małgorzata
M
Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.
Kluczyk
Alicja
A
Stefanowicz
Piotr
P
Bartosz-Bechowski
Hubert
H
Szewczuk
Zbigniew
Z
D000409:Alanine / Q000737:chemistry*; D006690:Bisbenzimidazole / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*
D010455:Peptides; D006690:Bisbenzimidazole; D000409:Alanine