Gingival enlargement as a manifestation of tuberous sclerosis: case report and periodontal management.
BACKGROUND
Tuberous sclerosis is an autosomal-dominant inherited disease involving many organs of the body. Oral manifestations include gingival enlargement, fibromas, and dental enamel pitting. The report presents a case of tuberous sclerosis with gingival enlargement histologically consistent with angiofibroma, describes its successful periodontal management, and reviews the literature associated with oral manifestations of tuberous sclerosis.


METHODS
A 26-year-old white male presented to the Department of Periodontics and Implant Dentistry, New York University College of Dentistry, with a diagnosis of tuberous sclerosis and a chief complaint of gingival enlargement affecting mastication and esthetics. Following a complete medical history review, consultation with the patient's medical team at New York University Medical Center, and a thorough oral and periodontal examination, a treatment plan was developed that included oral hygiene instructions, mechanical debridement, and periodontal reevaluation. This was followed by gingivectomy, which provided improved function and esthetics. Excised tissue was submitted for histologic examination. The patient was followed every 2 months for assessment of the outcome of the surgical treatment. An extensive search of the dental and dermatologic literature was performed on MEDLINE.


RESULTS
Histologic examination of the gingival tissue revealed features consistent with angiofibroma. Fifteen months following gingivectomy, the contours and gingival surface appearance remained normal.


CONCLUSIONS
The gingival enlargement was histologically consistent with the characteristic angiofibromas of tuberous sclerosis. The gingival enlargement responded very well to gingivectomy and periodontal maintenance.
Korol
Urszula B
UB
Department of Periodontics and Implant Dentistry, New York University College of Dentistry, New York, NY, USA.
Schoor
Robert
R
Nanda
Veena
V
Almas
Khalid
K
Phelan
Joan A
JA
D000328:Adult; D018322:Angiofibroma / Q000473:pathology; D003646:Debridement; D012534:Dental Scaling; D005500:Follow-Up Studies; D005887:Gingival Neoplasms / Q000473:pathology; D019214:Gingival Overgrowth / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005890:Gingivectomy; D006801:Humans; D008297:Male; D014099:Toothbrushing; D014402:Tuberous Sclerosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy