title: Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province, China, in 2006.
abstract: We determined the genetic relationships and origin of the dengue virus (DENV) responsible for an outbreak of dengue fever (DF) in Guangdong province, China, in 2006. Five DENV type 1 (DENV-1) isolates were obtained from human serum samples collected from DF patients during the outbreak. The nucleotide sequences of the E (envelope) gene were compared with those of 48 previous DENV-1 isolates: 18 from Guangdong province, one from Fujian province, one from Zhejiang province, and 28 from other countries in the South Asian region. The results suggested that four DENV-1 isolates identified in Guangdong province in 2006 might be in general circulation there, although these DENV-1 viruses may have been originally introduced into the province from other countries. In contrast, one isolate from Guangzhou city in 2006, may have been introduced by a recently imported case from Cambodia.
authors.affiliation: Center for Diseases Control and Prevention of Guangdong province, Guangzhou, PR China.
authors.forename: K
authors.initials: K
authors.lastname: Zheng
authors.forename: H-Q
authors.initials: HQ
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Yan
authors.forename: C-W
authors.initials: CW
authors.lastname: Ke
authors.forename: A
authors.initials: A
authors.lastname: Maeda
authors.forename: J
authors.initials: J
authors.lastname: Maeda
authors.forename: I
authors.initials: I
authors.lastname: Takashima
authors.forename: I
authors.initials: I
authors.lastname: Kurane
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.forename: X-M
authors.initials: XM
authors.lastname: Xie
mesh_terms: D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics*; D004196:Disease Outbreaks; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D044967:Serum / Q000821:virology; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus