title: Insulin-like growth factor 1, insulin-like growth factor-binding protein 3, and testicular germ-cell tumor risk.
abstract: Studies have consistently shown that taller men are at increased risk of testicular germ-cell tumors. Thus, it is plausible that factors associated with height may also influence risk of these tumors. The authors examined associations between testicular germ-cell tumor risk and circulating concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) among 517 cases and 790 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study (2002-2005). Odds ratios and 95% confidence intervals were estimated using logistic regression models, adjusting for age, race/ethnicity, height, and body mass index. All tests of significance were two-sided. Overall, there were no associations between IGF-1 or IGFBP-3 concentrations and risk of testicular germ-cell tumors (p > 0.05). However, when cases were separated by histologic type, there was a suggestion of a reduction in seminoma risk associated with the highest concentrations of IGF-1 as compared with the lowest concentrations (odds ratio = 0.66, 95% confidence interval: 0.40, 1.09). Although there were no overall associations with insulin-like growth factor, contrary to expectation, there was a suggestion that IGF-1 concentrations may be inversely associated with risk of seminoma.
authors.affiliation: Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Suite 550, 6120 Executive Boulevard, Rockville, MD 20892-7234, USA. chiav@mail.nih.gov
authors.forename: Victoria M
authors.initials: VM
authors.lastname: Chia
authors.forename: Sabah M
authors.initials: SM
authors.lastname: Quraishi
authors.forename: Barry I
authors.initials: BI
authors.lastname: Graubard
authors.forename: Mark V
authors.initials: MV
authors.lastname: Rubertone
authors.forename: Ralph L
authors.initials: RL
authors.lastname: Erickson
authors.forename: Frank Z
authors.initials: FZ
authors.lastname: Stanczyk
authors.forename: Katherine A
authors.initials: KA
authors.lastname: McGlynn
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D006306:Health Surveys; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000453:epidemiology*; D018570:Risk Assessment; D012307:Risk Factors; D018239:Seminoma / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013736:Testicular Neoplasms / Q000097:blood / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I