title: Optical molecular imaging: from single cell to patient.
abstract: Optical imaging is an emerging field with a wide range of biomedical research and clinical applications, both current and future. It comprises several classes of techniques that are capable of providing information at the molecular, cellular, tissue, and whole-animal levels. These techniques match well with emerging genomic and proteomic technologies that enable development of optical "probes," as well as with nanotechnologies for multifunctional imaging and drug delivery. These advances have enormous potential to accelerate drug discovery/development by providing predictive information on mechanisms of action and biological responses.
authors.affiliation: Division of Biophysics and Bioimaging, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: E H
authors.initials: EH
authors.lastname: Moriyama
authors.forename: G
authors.initials: G
authors.lastname: Zheng
authors.forename: B C
authors.initials: BC
authors.lastname: Wilson
mesh_terms: D000818:Animals; D004724:Endoscopy; D006801:Humans; D008164:Luminescent Proteins; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D055095:Optics and Photonics; D011237:Predictive Value of Tests; D041623:Tomography, Optical Coherence
chemical_list: D008164:Luminescent Proteins