Pustulosis acuta generalisata with joint involvement in an HLA-A2- and HLA-B35-positive patient.
Pustulosis acuta generalisata (PAG) is a rare poststreptococcal disease of the skin, which has been reported in children and adults after streptococcal throat infection. Herein, we report on the case of a 47-year-old woman with typical clinical and histologic findings of PAG emerging after a pharyngeal infection in whom inflammatory joint-involvement developed. The patient was found to be HLA-A2 and HLA-B35 positive. Whereas HLA-B35 might be associated with pustular skin diseases, HLA-A2 is a risk factor for the development of rheumatoid arthritis.
Eren
Mittra
M
Department of Dermatology, Venerology und Allergology, University of Cologne, Cologne, Germany.
Fabri
Mario
M
Krieg
Thomas
T
Eming
Sabine A
SA
D000208:Acute Disease; D001168:Arthritis / Q000097:blood / Q000150:complications*; D005260:Female; D015789:HLA-A2 Antigen / Q000097:blood*; D015797:HLA-B35 Antigen / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000097:blood / Q000150:complications* / Q000175:diagnosis*
D015789:HLA-A2 Antigen; D015797:HLA-B35 Antigen