title: A Mouse Model of Metabolic Syndrome; Increase in Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin Resistance in High-Fat Diet-Fed Male KK/Ta Mice.
abstract: To determine the relative contribution of obesity and visceral white adipose tissue (WAT) to metabolic syndrome, we developed a model that is susceptible to high-fat diet-induced obesity and insulin resistance using male KK/Ta mice. The ratio of WAT weight to body weight was greater in the high-fat diet group compared with the control group in 10-, 14-, and 22-week-old mice. The increase in visceral WAT preceded development of fatty liver and insulin resistance. Adiponectin mRNA expression in WAT was markedly decreased before the decrease in its plasma levels or the development of insulin resistance. Insulin resistance appeared in association with fatty infiltration and TNF-alpha expression in the liver in 22-week-old mice. These data indicate that our mouse model would be useful for future studies that investigate the role of visceral WAT and its products in the development of metabolic syndrome.
authors.affiliation: Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Akagiri
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Katsura
authors.initials: K
authors.lastname: Mizushima
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Osamu
authors.initials: O
authors.lastname: Handa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kokura
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa