title: Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.
abstract: Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
authors.affiliation: Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy & Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.
authors.forename: Ivar
authors.initials: I
authors.lastname: Mendez
authors.forename: Angel
authors.initials: A
authors.lastname: Viñuela
authors.forename: Arnar
authors.initials: A
authors.lastname: Astradsson
authors.forename: Karim
authors.initials: K
authors.lastname: Mukhida
authors.forename: Penelope
authors.initials: P
authors.lastname: Hallett
authors.forename: Harold
authors.initials: H
authors.lastname: Robertson
authors.forename: Travis
authors.initials: T
authors.lastname: Tierney
authors.forename: Renn
authors.initials: R
authors.lastname: Holness
authors.forename: Alain
authors.initials: A
authors.lastname: Dagher
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Ole
authors.initials: O
authors.lastname: Isacson
mesh_terms: D016380:Brain Tissue Transplantation / Q000379:methods / Q000473:pathology*; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D049268:Positron-Emission Tomography; D016896:Treatment Outcome; D014446:Tyrosine 3-Monooxygenase
chemical_list: D014446:Tyrosine 3-Monooxygenase