title: Comparing methods for full versus single technology appraisal: a case study of docetaxel and paclitaxel for early breast cancer.
abstract: OBJECTIVE
  The aim of this study is to compare and contrast the reports of the rapid National Institute for Health and Clinical Excellence (NICE) single technology (STA) process with the full Health Technology Assessment Report (TAR) for the same technologies (docetaxel and paclitaxel for the adjuvant treatment of early breast cancer).
  
  
  METHODS
  Documentary analysis was used to compare three reports. A data extraction form was developed to record information on the decision problem addressed in each report, literature searching methods, the clinical effectiveness review, cost-effectiveness analysis, conclusions and issues of concern.
  
  
  RESULTS
  The decision problems and search strategies for the STAs differed from those reported in the TAR. Not all trials of clinical effectiveness included in the TAR were reported by manufacturers. The methods and assumptions used to assess the cost-effectiveness of the technologies were generally similar between reports, although only one common health economic comparison was presented across the three reports. The TAR supports the STA results for docetaxel but suggested that the manufacturer's cost-effectiveness estimates for paclitaxel were highly optimistic.
  
  
  CONCLUSIONS
  Although the STA process provides the opportunity for rapid appraisal of new technologies, there remains uncertainty concerning the extent to which STAs adequately address the specific decision problem under consideration.
authors.affiliation: School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK. e.kaltenthaler@sheffield.ac.uk
authors.forename: Eva
authors.initials: E
authors.lastname: Kaltenthaler
authors.forename: Paul
authors.initials: P
authors.lastname: Tappenden
authors.forename: Andrew
authors.initials: A
authors.lastname: Booth
authors.forename: Ron
authors.initials: R
authors.lastname: Akehurst
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D003362:Cost-Benefit Analysis; D003657:Decision Making; D000077143:Docetaxel; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000191:economics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D043823:Taxoids / Q000191:economics / Q000627:therapeutic use*; D013673:Technology Assessment, Biomedical / Q000379:methods*; D035501:Uncertainty
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel