title: Crystal structure and antitumor activity of the novel zwitterionic complex of tri-n-butyltin(IV) with 2-thiobarbituric acid.
abstract: A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)(3)Sn(TBA) H(2)O] (1) has been synthesized and characterized by elemental analysis and (119)Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120(2) K. The geometry around Sn(IV) is trigonal bipyramidal. Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound 1 exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhibition caused by 1, in the rate of lipoxygenase (LOX) catalyzed oxidation reaction of linoleic acid to hyperoxolinoleic acid, has been also kinetically and theoretically studied. The results are compared to that of cisplatin.
authors.affiliation: Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
authors.forename: Vasilios I
authors.initials: VI
authors.lastname: Balas
authors.forename: Sotiris K
authors.initials: SK
authors.lastname: Hadjikakou
authors.forename: Nick
authors.initials: N
authors.lastname: Hadjiliadis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kourkoumelis
authors.forename: Mark E
authors.initials: ME
authors.lastname: Light
authors.forename: Mike
authors.initials: M
authors.lastname: Hursthouse
authors.forename: Apostolos K
authors.initials: AK
authors.lastname: Metsios
authors.forename: Spyros
authors.initials: S
authors.lastname: Karkabounas