title: Ontogeny of thyrotropin-releasing hormone biosynthesis and release in hypothalamic neurons.
abstract: Thyrotropin-releasing hormone (TRH) is expressed at early postmitotic stages of hypothalamic neuron development, in the mouse and rat, as revealed by the presence of the mature peptide, of pro-TRH mRNAs, and of large precursor forms. This indicates a coordinate expression of several genes encoding, respectively, pro-TRH, its processing enzymes, and the cell machinery for intracellular transport, sorting, and release of TRH. During development, an acceleration of pro-TRH processing is revealed by an increased proportion of the mature peptide. This is correlated with changes in the respective distribution of pro-TRH and TRH along neurites and the ontogenesis of neurosecretory granules.
authors.affiliation: Cellular and Molecular Endocrinology Group, URA CNRS 1115, College of France, Paris Cedex 5, France.
authors.forename: A
authors.initials: A
authors.lastname: Tixier-Vidal
authors.forename: A
authors.initials: A
authors.lastname: Faivre-Bauman