title: Heterotopic ossification due to neuromuscular blocking agent in adult respiratory distress syndrome. A case report.
abstract: Heterotopic ossification (HO) is the formation of mature bone in soft tissues, which can be seen either in cases of traumatic injury or nontraumatic conditions. HO is more commonly observed after a traumatic event, such as a spinal cord injury or head injury. Although less common, it can also be seen after nontraumatic neurological conditions, such as long term coma or neuromuscular blockade. Patients with adult respiratory distress syndrome (ARDS) are at risk of developing HO, due to a prolonged mechanical ventilation period and exposure to neuromuscular blocking agents. In this case report, the authors describe a 51-year-old woman with ARDS, whose HO developed after long-term sedation with neuromuscular blockade agents.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Gazi University Medical Faculty, -6500 Bepevler, Ankara, Turkey. muratz@gazi.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Zynnurodlu
authors.forename: G
authors.initials: G
authors.lastname: Kaymak Karatap
authors.forename: V
authors.initials: V
authors.lastname: Sepycy
mesh_terms: D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000009:adverse effects*; D009999:Ossification, Heterotopic / Q000139:chemically induced* / Q000175:diagnosis; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000628:therapy*
chemical_list: D009466:Neuromuscular Blocking Agents