Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa.
Two new linear lipopeptides, 1 and 2, and a known compound, curacin D, have been isolated from a marine cyanobacterium, brown Lyngbya polychroa, collected from Hollywood Beach, Fort Lauderdale, Florida. Their planar structures were elucidated by 1D and 2D NMR techniques, and absolute configurations were assigned using chiral HPLC. The new compounds were assigned the trivial names dragonamide C (1) and dragonamide D (2), as their peptide moiety is related to previously reported dragonamides A and B.
Gunasekera
Sarath P
SP
Smithsonian Marine Station, Fort Pierce, FL 34949, USA.
Ross
Cliff
C
Paul
Valerie J
VJ
Matthew
Susan
S
Luesch
Hendrik
H
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005431:Florida; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D009842:Oligopeptides; C530239:dragonamide C; C530238:dragonamide D