[Total gastrectomy in the management of Ménétrie's disease. Institutional experience and review of the literature].
OBJECTIVE
Analyze retrospectively the clinical, histopathological and surgical characteristics of patients with Mindtrier's disease (MD) at our Institution.


BACKGROUND
Ménétrier's disease (MD) includes hipertophy of gastric mucosa, hipo or hiperchloridria and severe hipoalbuminemia. In the literature, it has been underestimated its relationship with the development of gastric carcinoma.


METHODS
We analyzed retrospectively the clinical trials of patients with MD treated surgically at our Institution during the last three decades (From 1970 through 2002).


RESULTS
Three patients with clinical diagnosis of MD underwent total gastrectomy during the study period. All of them were corroborated histopathologically and in one patient carcinoma in situ was demonstrated in the surgical specimen.


CONCLUSIONS
There is a very limited experience with surgical treatment of MD and it is limited to patients who have severe hipoalbuminemia or associated malignant disease. However accordig to our experience and literature review, surgical treatment should be considered early in the course of the disease for the relationship between MD and gastric adenocarcinoma.
García-Alvarez
Miriam N
MN
Sección de Cirugia Oncológica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, DF México.
Plata-Muñoz
Juan José
JJ
Medina-Franco
Heriberto
H
D000328:Adult; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005758:Gastritis, Hypertrophic / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies