Feasibility of induction heating using a sintered MgFe2O4 needle for minimally invasive breast cancer therapy.
BACKGROUND
This study investigated a novel approach for tumor ablation therapy using an alternating magnetic field combined with a sintered MgFe2O4 needle. This method differs from radiofrequency ablation (RFA) by dielectric heating with regard to the heating mechanism and improves some weak points of these conventional thermotherapies.


METHODS
Nude mice mimicking human breast cancer BT474 were treated using this method. The extent of tumor death was assessed after ablation.


RESULTS
Staining with hematoxylin and eosin showed gradual expansion of the pyknotic area until 48 h after ablation. Nicotinamide adenine dinucleotide diaphorase staining also showed complete tumor death by 48 h after treatment. The ablation area was well controlled and reablation was not necessary. The tumor could be completely controlled using this method without any risk of skin burn.


CONCLUSIONS
This novel ablation therapy appeared to be more effective and less invasive for treatment of breast cancer treatment than RFA.
Yukumi
Shungo
S
Department of Organ Regenerative Surgery, Ehime University Shitsukawa, Toon-shi, Ehime, Japan. onsen@m.ehime-u.ac.jp
Watanabe
Yuji
Y
Horiuchi
Atsushi
A
Doi
Takashi
T
Sato
Kohichi
K
Yoshida
Motohira
M
Maehara
Tsunehiro
T
Aono
Hiromichi
H
Naohara
Takashi
T
Kawachi
Kanji
K
D000818:Animals; D001943:Breast Neoplasms / Q000601:surgery*; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D045744:Cell Line, Tumor; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods; D008277:Magnesium Oxide; D051379:Mice; D008819:Mice, Nude; D009339:Needles; D023041:Xenograft Model Antitumor Assays
D005290:Ferric Compounds; C000499:ferric oxide; D008277:Magnesium Oxide; D008058:Dihydrolipoamide Dehydrogenase