title: Brain anatomical structure segmentation by hybrid discriminative/generative models.
abstract: In this paper, a hybrid discriminative/generative model for brain anatomical structure segmentation is proposed. The learning aspect of the approach is emphasized. In the discriminative appearance models, various cues such as intensity and curvatures are combined to locally capture the complex appearances of different anatomical structures. A probabilistic boosting tree (PBT) framework is adopted to learn multiclass discriminative models that combine hundreds of features across different scales. On the generative model side, both global and local shape models are used to capture the shape information about each anatomical structure. The parameters to combine the discriminative appearance and generative shape models are also automatically learned. Thus, low-level and high-level information is learned and integrated in a hybrid model. Segmentations are obtained by minimizing an energy function associated with the proposed hybrid model. Finally, a grid-face structure is designed to explicitly represent the 3-D region topology. This representation handles an arbitrary number of regions and facilitates fast surface evolution. Our system was trained and tested on a set of 3-D magnetic resonance imaging (MRI) volumes and the results obtained are encouraging.
authors.affiliation: Laboratory of Neuro Imaging, UCLA Medical School, Los Angeles, CA 90095 USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Tu
authors.forename: K L
authors.initials: KL
authors.lastname: Narr
authors.forename: P
authors.initials: P
authors.lastname: Dollar
authors.forename: I
authors.initials: I
authors.lastname: Dinov
authors.forename: P M
authors.initials: PM
authors.lastname: Thompson
authors.forename: A W
authors.initials: AW
authors.lastname: Toga
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology*; D003198:Computer Simulation; D016002:Discriminant Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity