title: Graft-versus-lymphoma effect for aggressive T-cell lymphomas in adults: a study by the Société Francaise de Greffe de Moëlle et de Thérapie Cellulaire.
abstract: OBJECTIVE
  Aggressive T-cell lymphomas (ATCLs) represent 10% to 15% of non-Hodgkin's lymphomas (NHLs) in adults. ATCLs show a worse prognosis than B-cell lymphomas.
  
  
  METHODS
  On behalf of the Société Française de Greffe de Moëlle et de Thérapie Cellulaire, we conducted a retrospective analysis including 77 ATCL patients who underwent allogeneic stem-cell transplantation (alloSCT).
  
  
  RESULTS
  The different diagnosis included anaplastic large-cell lymphoma (ALCL; n = 27), peripheral T-cell lymphoma not otherwise specified (PTCL-NOS; n = 27), angioimmunoblastic T-cell lymphoma (AITL; n = 11), hepatosplenic gamma/delta lymphoma (HSL; n = 3), T-cell granular lymphocytic leukemia (T-GLL; n = 1), nasal natural killer (NK)/T-cell lymphoma (nasal-NK/L; n = 3) or non-nasal NK/T-cell lymphoma (non-nasal-NK/L; n = 2), enteropathy-type T-cell (n = 1), and human T-lymphotropic virus (HTLV)-1 lymphoma (n = 2). Fifty-seven patients received a myeloablative conditioning regimen. Donors were human leukocyte antigen (HLA)-matched in 70 cases and related in 60 cases. Thirty-one patients were in complete remission (CR) at the time of alloSCT, whereas 26 were in partial response (PR). Five-year toxicity-related mortality (TRM) incidence was 33% (95% CI, 24% to 46%). The 5-year overall survival (OS) and event-free survival (EFS) rates were 57% (95% CI, 45% to 68%) and 53% (95% CI, 41% to 64%), respectively. In multivariate analysis, chemoresistant disease (stable, refractory, or progressing disease) at the time of alloSCT and the occurrence of severe grade 3 to 4 acute graft-versus-host disease (aGVHD) were the strongest adverse prognostic factors for OS (P = .03 and .03, respectively). Disease status at transplantation significantly influenced the 5-year EFS (P = .003), and an HLA-mismatched donor increased TRM (P = .04).
  
  
  CONCLUSIONS
  We conclude that alloSCT is a potentially efficient therapy for NK/T lymphomas and is worth further investigation through prospective clinical trials.
authors.affiliation: Hematology Department, University Hospital, Hôtel-Dieu, Nantes, France. steven.legouill@chu-nantes.fr
authors.forename: Steven
authors.initials: S
authors.lastname: Le Gouill
authors.forename: Noel
authors.initials: N
authors.lastname: Milpied
authors.forename: Agnès
authors.initials: A
authors.lastname: Buzyn
authors.forename: Régis Peffault
authors.initials: RP
authors.lastname: De Latour
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Vernant
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Moles
authors.forename: Krimo
authors.initials: K
authors.lastname: Bouabdallah
authors.forename: Claude-Eric
authors.initials: CE
authors.lastname: Bulabois
authors.forename: Jehan
authors.initials: J
authors.lastname: Dupuis
authors.forename: Bernard
authors.initials: B
authors.lastname: Rio
authors.forename: Nicole
authors.initials: N
authors.lastname: Gratecos
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
authors.forename: Michel
authors.initials: M
authors.lastname: Attal
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
authors.forename: Didier
authors.initials: D
authors.lastname: Decaudin
authors.forename: Jean-Henry
authors.initials: JH
authors.lastname: Bourhis
authors.forename: Didier
authors.initials: D
authors.lastname: Blaise
authors.forename: Christelle
authors.initials: C
authors.lastname: Volteau
authors.forename: Mauricette
authors.initials: M
authors.lastname: Michallet
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D020350:Graft vs Tumor Effect / Q000276:immunology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous / Q000276:immunology