title: Potential anthelmintic: D-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditis elegans.
abstract: No anthelmintic sugars have yet been identified. Eight ketohexose stereoisomers (D- and L-forms of psicose, fructose, tagatose and sorbose), along with D-galactose and D-glucose, were examined for potency against L1 stage Caenorhabditis elegans fed Escherichia coli. Of the sugars, D-psicose specifically inhibited the motility, growth and reproductive maturity of the L1 stage. D-Psicose probably interferes with the nematode nutrition. The present results suggest that D-psicose, one of the rare sugars, is a potential anthelmintic.
authors.affiliation: Department of Applied Biological Science, Kagawa University, 2393 Miki-Ikenobe, Kagawa, 761-0795, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kurose
authors.forename: Toru
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Ken
authors.initials: K
authors.lastname: Izumori
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects*; D005632:Fructose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005690:Galactose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006601:Hexoses / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D021261:Parasitic Sensitivity Tests; D013013:Sorbose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000969:Antinematodal Agents; D006601:Hexoses; C003243:psicose; D005632:Fructose; D005947:Glucose; D013013:Sorbose; C030192:tagatose; D005690:Galactose