[Transformation of bioprosthesis-artery anastomotic area after blood exposure: the effect of suture material].
Vascular graft implantation is accompanied with tissue reaction which is determined partially by the nature of suture material. In experiments in vitro edges of arterial diepoxid-preserved bioprostheses were sutured with Prolene filament, nickelide-titanium wire (TiNi) or absorbable polydioxanone monofilament (PDS). Morphological changes in anastomotic area after blood exposure were assessed with scanning electronic microscope. Protein deposits in anastomotic area were detected 5 min after blood exposure, being more loose and bulky around Prolene sutures. The protein layer became more compact 120 min since blood exposure. Most homogeneous protein sorption was over TiNi-sutured anastomoses. Suture material affected blood cells as well - some red cells have transformed into echinocytes. Heparin-modified samples demonstrated less negative impact of suture material in anastomotic area. The worst results after 120 min of blood exposure were obtained for PDS filaments.
Zhuravleva
I Iu
IIu
Research and Operating Laboratory of Heart and Vessel Reconstructive Surgery with Clinics, Siberian Branch of the Russian Academy of Medical Science, Kemerovo, Russia.
Kudriavtseva
Iu A
IuA
Zinchenko
S S
SS
Titov
A T
AT
Barbarash
L S
LS
D000714:Anastomosis, Surgical; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology; D001158:Arteries / Q000601:surgery*; D001705:Bioprosthesis; D004912:Erythrocytes / Q000378:metabolism; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D013537:Sutures
D000925:Anticoagulants; D006493:Heparin