New, general, and practical preparation of methyl ketones via the direct coupling of amides with CH2Cl2 promoted by TiCl4/Mg.
The direct coupling of a variety of amides with CH2 Cl2 or CD2 Cl2 promoted by TiCl 4/Mg/THF provides an extremely simple, practical, selective, and efficient approach for the construction of methyl ketones. The efficiency and practicability of this chemistry is illustrated by the very simple synthesis of deuterated methyl ketones.
Lin
Kuo-Wei
KW
Department of Chemistry, National Chung-Hsing University, Taichung 400, Taiwan, Republic of China.
Tsai
Chi-Hui
CH
Hsieh
I-Lin
IL
Yan
Tu-Hsin
TH
D000577:Amides / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000577:Amides; D007659:Ketones; D008752:Methylene Chloride; C025096:titanium tetrachloride; D014025:Titanium; D008274:Magnesium