A new prenylated dihydrochalcone from the leaves of Artocarpus lowii.
A new prenylated dihydrochalcone, 2',4'-dihydroxy-4-methoxy-3'-prenyldihydrochalcone (1), along with two known compounds, 2',4',4-trihydroxy-3'-prenylchalcone (2) and 2',4-dihydroxy-3',4'-(2,2-dimethylchromene)chalcone (3) were isolated from the leaves of Artocarpus lowii. The structures of 1-3 were elucidated by spectroscopic methods and by comparison with data reported in the literature. Compounds 1-3 showed strong free radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) measured by electron spin resonance (ESR) spectrometry.
Jamil
Shajarahtunnur
S
Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, UTM Skudai, 81310, Johor Bahru, Johor, Malaysia. shaja@kimia.fs.utm.my
Sirat
Hasnah Mohd
HM
Jantan
Ibrahim
I
Aimi
Norio
N
Kitajima
Mariko
M
D031622:Artocarpus / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D013057:Spectrum Analysis
C529870:2',4',4-trihydroxy-3'-prenylchalcone; C529869:2',4'-dihydroxy-4-methoxy-3'-prenyldihydrochalcone; C529871:2',4-dihydroxy-3',4'-(2,2-dimethylchromene)chalcone; D047188:Chalcones; D016166:Free Radical Scavengers; D005609:Free Radicals; D010936:Plant Extracts