title: The obesity epidemic: pharmacological challenges.
abstract: Obesity, defined by a body mass index greater than 30kg/m(2), claims an increasing number of lives every year, underscoring a dire need for effective therapeutic interventions. The origins of the obesity epidemic are complex, but commonly cited factors include the large quantities of calorie-rich food that are readily accessible in modern society; eating habits adapted to fast-paced lifestyles; low levels of physical activity; and genetic programs that have evolved, especially in populations prone to famine, to favor the storage of excess calories (i.e., the thrifty-gene theory). It is estimated that more than thirty percent of adults, and about fifteen percent of juveniles, are obese. These high rates have led to dramatic increases in diseases such as type 2 diabetes, cardiovascular and respiratory diseases, depression, and some forms of cancer.
authors.affiliation: Hammersmith Hospital, Imperial College , London, UK W120NN.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bloom
authors.forename: Francis P
authors.initials: FP
authors.lastname: Kuhajda
authors.forename: Ismail
authors.initials: I
authors.lastname: Laher
authors.forename: Xavier
authors.initials: X
authors.lastname: Pi-Sunyer
authors.forename: Gabriele V
authors.initials: GV
authors.lastname: Ronnett
authors.forename: Tricia M M
authors.initials: TM
authors.lastname: Tan
authors.forename: David S
authors.initials: DS
authors.lastname: Weigle
mesh_terms: D019440:Anti-Obesity Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000453:epidemiology*; D036361:Peptide Hormones / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D063385:Cannabinoid Receptor Modulators; D036361:Peptide Hormones