Acute stroke imaging research roadmap.
The recent "Advanced Neuroimaging for Acute Stroke Treatment" meeting on September 7 and 8, 2007 in Washington DC, brought together stroke neurologists, neuroradiologists, emergency physicians, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), industry representatives, and members of the US Food and Drug Administration (FDA) to discuss the role of advanced neuroimaging in acute stroke treatment. The goals of the meeting were to assess state-of-the-art practice in terms of acute stroke imaging research and to propose specific recommendations regarding: (1) the standardization of perfusion and penumbral imaging techniques, (2) the validation of the accuracy and clinical utility of imaging markers of the ischemic penumbra, (3) the validation of imaging biomarkers relevant to clinical outcomes, and (4) the creation of a central repository to achieve these goals. The present article summarizes these recommendations and examines practical steps to achieve them.
Wintermark
Max
M
University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143-0628, USA. Max.Wintermark@radiology.ucsf.edu
Albers
Gregory W
GW
Alexandrov
Andrei V
AV
Alger
Jeffry R
JR
Bammer
Roland
R
Baron
Jean-Claude
JC
Davis
Stephen
S
Demaerschalk
Bart M
BM
Derdeyn
Colin P
CP
Donnan
Geoffrey A
GA
Eastwood
James D
JD
Fiebach
Jochen B
JB
Fisher
Marc
M
Furie
Karen L
KL
Goldmakher
Gregory V
GV
Hacke
Werner
W
Kidwell
Chelsea S
CS
Kloska
Stephan P
SP
Köhrmann
Martin
M
Koroshetz
Walter
W
Lee
Ting-Yim
TY
Lees
Kennedy R
KR
Lev
Michael H
MH
Liebeskind
David S
DS
Ostergaard
Leif
L
Powers
William J
WJ
Provenzale
James
J
Schellinger
Peter
P
Silbergleit
Robert
R
Sorensen
Alma Gregory
AG
Wardlaw
Joanna
J
Wu
Ona
O
Warach
Steven
S
D000368:Aged; D019985:Benchmarking; D015415:Biomarkers; D002545:Brain Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation; D016000:Cluster Analysis; D019992:Databases as Topic; D003952:Diagnostic Imaging / Q000379:methods / Q000592:standards* / Q000639:trends*; D005260:Female; D019983:Guideline Adherence; D017052:Hospital Mortality; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods / Q000592:standards / Q000639:trends; D008297:Male; D010477:Perfusion / Q000379:methods / Q000592:standards; D012044:Regression Analysis; D020521:Stroke / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards / Q000639:trends; D054928:Validation Studies as Topic
D015415:Biomarkers