A patient with diffuse large B-cell non-Hodgkin's lymphoma and AA type amyloidosis.
AA-type amyloidosis is a consequence of a long-standing systemic inflammation and is not associated with a monoclonal protein or clonal bone marrow plasma cells. Proinflammatory cytokines such as interleukin (IL)1, IL-6, and tumor necrosis factor (TNF) stimulate the synthesis of serum amyloid A during inflammation. Although the association of non-Hodgkin's lymphoma (NHL) with AL-type amyloidosis is well known and patients with Hodgkin's lymphoma with AA amyloidosis have been described, AA-type amyloidosis with NHL is extremely infrequent. We report a case of amyloidosis associated with NHL that subsided during R-CHOP chemotherapy.
Piskin
O
O
Department of Hematology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
Alacacioglu
I
I
Ozkal
S
S
Ozcan
M A
MA
Demirkan
F
F
Hayri Ozsan
G
G
Kargi
A
A
Undar
B
B
D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000378:metabolism*
D000685:Serum Amyloid A Protein