Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation.
We report the results of iron chelating treatment with deferiprone in a 61-year-old woman with signs and symptoms of neurodegeneration with brain iron accumulation (NBIA). After 6 months of therapy the patient's gait had improved and a reduction in the incidence of choreic dyskinesias was observed. Her gait returned to normal after an additional 2 months of therapy, at which time there was a further reduction in involuntary movements and a partial resolution of the blepharospasm.
Forni
Gian Luca
GL
Centro della Microcitemia e Anemie Congenite, Ospedale Galliera, Genoa, Italy. gianluca.forni@galliera.it
Balocco
Manuela
M
Cremonesi
Laura
L
Abbruzzese
Giovanni
G
Parodi
Roberto Carlo
RC
Marchese
Roberta
R
D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D020820:Dyskinesias / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D009410:Nerve Degeneration / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D007502:Iron Chelating Agents; D007501:Iron