Polymorphisms of TNF-alpha and LT-alpha genes in multiple myeloma.
Allelic distribution of -308 G>A (TNF 1/2) polymorphism of the TNF-alpha, and the +252 A>G promoter polymorphism of the LT-alpha gene, the 1267 A>G polymorphism of the HSP70-2 gene as well as the -429 T>C promoter polymorphism of the RAGE gene were tested in 94 MM cases and 141 controls. Significantly less MM patients than controls carried the TNF2 allele (p=0.018) and the TNF2-LTA 252G haplotype (p=0.025). The difference was, however, restricted to the females, as well as the relatively young (<69 years) subjects. By contrast, we did not find differences with the other SNPs tested.
Kádár
Katalin
K
Kútvölgyi Clinical Centre, Semmelweis University, Budapest, Hungary.
Kovács
Margit
M
Karádi
István
I
Melegh
Béla
B
Pocsai
Zsuzsa
Z
Mikala
Gábor
G
Tordai
Attila
A
Szilágyi
Agnes
A
Adány
Róza
R
Füst
George
G
Várkonyi
Judit
J
D000368:Aged; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha