[Comparison and relevance of rheumatoid factors, antikeratin antibodies and anti-cyclic citrullinated peptides antibodies in rheumatoid arthritis].
OBJECTIVE
to evaluate specificity and sensibility of the rheumatoid factors (RF), the anti-cyclic citrullinated peptide antibodies (CCP) and the anti-keratin antibodies (AKA) according to the rheumatoid arthritis (RA) diagnosis; pathology other than RA with at least one of these marker positive; the significance of the flocculent fluorescence of the antibodies AKA by indirect immunofluorescence (IIF).


METHODS
two hundred forty height patients were studied: 121 RA, 89 inflammatory rheumatisms, 23 non inflammatory rheumatisms, and 15 non rheumatic affections. The RF was investigated by nephelometry, the anti-CCP by immunofluorometry and the AKA by IIF on rat oesophagus.


RESULTS
specificity and sensibility were respectively in a retrospective manner: 68% and 83% for the RF, 95% and 76% for the anti- CCP, 83% and 40% for the AKA during RA with evolution of less than one year. The rates of agreements were: RF versus CCP: 81%, RF versus AKA: 57%, CCP versus AKA: 73%. Twelve patients with pathologies different from RA have positive anti-CCP or AKA. Thirty three of the patients with anti-CCP level superior to 130 U/mL have flocculent AKA versus only 5% when the anti-CCP are lower than 130 U/mL.


CONCLUSIONS
the RF and the anti-CCP are complementary in RA. Autoimmune and neoplasic pathologies are sometimes responsible for the positivity of the anti-CCP and the AKA. The flocculent aspect of AKA in IIF may be associated with raised concentrations of anti-CCP.
Galati
S
S
Université d'Angers, UPRES EA 3863, CHU d'Angers, Laboratoire d'immunologie et d'allergologie, Angers.
Beauvillain
C
C
Renier
G
G
Jeannin
P
P
Masson
C
C
Chevailler
A
A
D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005428:Flocculation Tests; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D006801:Humans; D007633:Keratins / Q000276:immunology*; D015337:Multicenter Studies as Topic; D009391:Nephelometry and Turbidimetry; D010456:Peptides, Cyclic / Q000276:immunology*; D012189:Retrospective Studies; D012217:Rheumatoid Factor / Q000097:blood*; D012680:Sensitivity and Specificity; D013997:Time Factors
D001323:Autoantibodies; D015415:Biomarkers; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D007633:Keratins; D012217:Rheumatoid Factor