title: Primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries.
abstract: Disseminated signet ring cell carcinomas frequently arise from the stomach. However, primaries in the colon and rectum have also been reported. We present a 68 year old lady who presented with a change in her bowel habit. Colonoscopy showed a stenosing rectal tumour at 7 cm to 8 cm from the anal verge. Multiple scattered ulcers were also noted along the entire length of the colon. Biopsy of the lesions revealed signet ring cell adenocarcinoma. Gastroscopy showed multiple nodules with ulceration over several areas of the stomach which were similar in appearance to the colonic lesions. However, no primary tumour of the stomach was seen. Biopsy of the gastric lesions also showed signet ring cell adenocarcinoma. Computed tomography scan of the abdomen and pelvis revealed circumferential tumour at the rectosigmoid junction with possible invasion into the left ischiorectal fossa. The overall picture was that of a primary rectal signet ring cell carcinoma with peritoneal dissemination. The patient was referred for palliative chemotherapy in view of the disseminated disease. In the present report, we discuss this interesting pathological entity and review the role of various histolological techniques in helping to identify the primary tumor.
authors.affiliation: Department of Surgery, Alexandra Hospital, 378 Alexandra Road, 159964, Singapore. selina_sim@hotmail.com
authors.forename: Hsien-Lin
authors.initials: HL
authors.lastname: Sim
authors.forename: Kok-Yang
authors.initials: KY
authors.lastname: Tan
authors.forename: Pak-Leng
authors.initials: PL
authors.lastname: Poon
authors.forename: Anton
authors.initials: A
authors.lastname: Cheng
mesh_terms: D000368:Aged; D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010537:Peritoneum / Q000473:pathology*; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013274:Stomach Neoplasms / Q000556:secondary