title: Detection and management of early diabetic nephropathy.
abstract: It has proven difficult to alter the progression of diabetic nephropathy once overt proteinuria is established. The presence of microalbuminuria reflects an early renal lesion that may be more amenable to therapeutic intervention. Dietary protein restriction, improved glycemic control, and aggressive treatment of high blood pressure all have shown beneficial effects in some patients. Angiotensin-converting enzyme inhibitor therapy may offer specific advantages in terms of its renal protective effects.
authors.affiliation: Divisions of Endocrinology and Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Crandall
authors.forename: G B
authors.initials: GB
authors.lastname: Appel