title: The inflammatory response to femoral arterial closure devices: a randomized comparison among FemoStop, AngioSeal, and Perclose.
abstract: The objectives of this study were to investigate whether the systemic inflammatory response differs, in patients undergoing coronary angiography, among the arterial closure devices FemoStop, AngioSeal, and Perclose. The study is a prospective and randomized study. We measured pre- and postprocedural C-reactive protein (CRP), fibrinogen, and interleukin-6 (IL-6) plasma levels and collected clinical and procedural data on 77 patients who underwent coronary angiography because of stable angina pectoris. Patients were randomized to the following device: FemoStop (mechanical compression), AngioSeal (anchor and collagen sponge), or Perclose (nonabsorbable suture). No patient group experienced an increased incidence of vascular complications. There were no differences among the three groups regarding CRP, fibrinogen, or IL-6 values before or after coronary angiography. IL-6 levels increased 6 h after the procedure in all groups (p < 0.01), however, the increase did not differ among the groups. After 30 days there were no increased values of CRP or fibrinogen. We conclude that the femoral arterial closure devices AngioSeal and Perclose do not enhance an inflammatory response after a diagnostic coronary angiography, measured by CRP, fibrinogen, and IL-6, compared to femoral arterial closure using a mechanical compression device.
authors.affiliation: Department of Cardiology, Karolinska University Hospital, Stockholm, 17176, Sweden. jens.jensen@karolinska.se
authors.forename: Jens
authors.initials: J
authors.lastname: Jensen
authors.forename: Nawzad
authors.initials: N
authors.lastname: Saleh
authors.forename: Ulf
authors.initials: U
authors.lastname: Jensen
authors.forename: Bertil
authors.initials: B
authors.lastname: Svane
authors.forename: Anders
authors.initials: A
authors.lastname: Jönsson
authors.forename: Per
authors.initials: P
authors.lastname: Tornvall
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D002097:C-Reactive Protein / Q000378:metabolism; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D017023:Coronary Angiography / Q000009:adverse effects* / Q000379:methods; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D005263:Femoral Artery; D005340:Fibrinogen / Q000378:metabolism; D006489:Hemostatic Techniques / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D005340:Fibrinogen; D002097:C-Reactive Protein