title: Complex I: a complex gateway to the powerhouse.
abstract: Complex I, the main entry point for electrons to the respiratory chain, is of critical importance for cellular energy homeostasis. In this issue of Cell Metabolism, Kruse and coworkers (2008) describe the first mouse knockout for a complex I structural subunit, thus advancing our understanding of complex I in disease.
authors.affiliation: Department of Laboratory Medicine, Karolinska Institutet, S-141 86 Stockholm, Sweden.
authors.forename: Fredrik Hansson
authors.initials: FH
authors.lastname: Sterky
authors.forename: Nils-Göran
authors.initials: NG
authors.lastname: Larsson
mesh_terms: D000818:Animals; D042967:Electron Transport Complex I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D028361:Mitochondrial Diseases / Q000378:metabolism*; D009154:Mutation; D009245:NADH Dehydrogenase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D009245:NADH Dehydrogenase; D042967:Electron Transport Complex I