Innate immunity: squelching anti-viral signalling with NLRX1.
Innate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers a signalling pathway involving the outer mitochondrial membrane protein MAVS. Recent work has identified that NLRX1, a member of another class of innate immune receptors, sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity.
O'Neill
Luke A J
LA
School of Biochemistry and Immunology, Trinity College Dublin, Ireland. laoneill@tcd.ie
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D012367:RNA, Viral / Q000276:immunology*; D011971:Receptors, Immunologic; D015398:Signal Transduction / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; C505371:MAVS protein, human; D024101:Mitochondrial Proteins; C527006:NLRX1 protein, human; D012367:RNA, Viral; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases