Familial multiple endocrine neoplasia type 1 Mutation of a tumor suppressor gene.
Familial multiple endocrine neoplasia type 1 (FMENI) is caused by mutation of a gene on the long arm of chromosome 11. Inactivation of both alleles at this locus in one cell is thought to cause loss of growth inhibition and development of a monoclonal tumor.
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Mineral Metabolism Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.