title: Synthesis, characterization and electrochemistry of 4'-functionalized 2,2':6',2''-terpyridine ruthenium(II) complexes and their biological activity.
abstract: The synthesis and characterization of Ru(II) terpyridine complexes derived from 4'-functionalized 2,2':6',2''-terpyridine ligands by a multi step procedure have been described. The complexes are redox-active, showing both metal-centred (oxidation) and ligand-centred (reduction) processes. The antibacterial and antifungal activity of the synthesized ruthenium(II) complexes [Ru(attpy)2](PF6)2 (attpy = 4'-(4-acryloyloxymethylphenyl)-2,2':6',2''-terpyridine); [Ru(mttpy)2](PF6)2 (mttpy = 4'-(4-methacryloyloxymethylphenyl)-2,2':6',2''- terpyridine); [Ru(mttpy)(MeOPhttpy)](PF6)2 (MeOPhttpy = 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine); and [Ru(mttpy)(ttpy)](PF6)2 (ttpy = 4'-(4-methylphenyl)-2,2':6',2''-terpyridine) were tested against four human pathogens (Proteus vulgaris, Proteus mirabilis, Pseudomonas aeruginosa and Escherichia coli) and five plant pathogens (Curvularia lunata, Fusarium oxysporum, Fusarium udum, Macrophomina phaseolina and Rhizoctonia solani) by the well diffusion method and MIC values of the complexes are reported. A biological study of the complexes indicated that the complexes [Ru(mttpy)2](PF6)2 and [Ru(mttpy)(MeOPhttpy)](PF6)2 exhibit very good activity against most of the test pathogens and their activity is better than those of some of the commercially available antibiotics like tetracycline and the fungicide carbendazim.
authors.affiliation: Department of Inorganic Chemistry, School of Chemical Sciences, University of Madras, Guindy Campus, Chennai, 600 025, India.
authors.forename: Arockiam
authors.initials: A
authors.lastname: Anthonysamy
authors.forename: Sengottuvelan
authors.initials: S
authors.lastname: Balasubramanian
authors.forename: Vellasamy
authors.initials: V
authors.lastname: Shanmugaiah
authors.forename: Narayanasamy
authors.initials: N
authors.lastname: Mathivanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects; D004563:Electrochemistry; D006801:Humans; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010944:Plants / Q000382:microbiology; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology; D012232:Rhizoctonia / Q000187:drug effects; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C529967:(4'-(4-methacryloyloxymethylphenyl)-2,2'-6',2''-terpyridine)(4'-(4-methoxyphenyl)-2,2'-6',2''-terpyridine)ruthenium(II); D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008024:Ligands; D009942:Organometallic Compounds; D011725:Pyridines; D012428:Ruthenium