In vivo Degradation and histocompatibility of a novel class of fluorescent copolyanhydrides, poly{[di(p-carboxyphenyl) succinate]-co-(sebacic anhydride)}.
In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymers was slower than that studied in vitro. A surface erosion characteristic of the copolyanhydrides was revealed by SEM and fluorescent microscopy. Mild inflammatory reactions were observed on days 6 and 10 after implantation for all the studied copolymers. By the end of 30 d, there were almost no inflammation reactions taking place.
Fan
Jun
J
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Li
Yan
Y
Jiang
Hongliang
H
Tang
Guping
G
Wang
Liqun
L
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry*; D005453:Fluorescence; D006648:Histocompatibility; D020007:Implants, Experimental / Q000592:standards*; D007249:Inflammation / Q000139:chemically induced*; D008422:Materials Testing; D049388:Polyanhydrides / Q000009:adverse effects* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D001672:Biocompatible Materials; D049388:Polyanhydrides