title: Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.
abstract: The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an alpha,beta-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland 4111.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fechner
authors.forename: Anthony
authors.initials: A
authors.lastname: Boyle
authors.forename: Moana
authors.initials: M
authors.lastname: Simpson
authors.forename: Rama
authors.initials: R
authors.lastname: Addepalli
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Tony
authors.initials: T
authors.lastname: Cheung
authors.forename: Huwei
authors.initials: H
authors.lastname: Chen
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D001315:Australia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C531268:aplysamine 6; C475724:bromotyrosine; D014443:Tyrosine; D011496:Protein Methyltransferases; C056501:protein-S-isoprenylcysteine O-methyltransferase