In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum.
A microdilution method was used to test 11 antifungal drugs against clinical isolates of Fusarium thapsinum and three different phylogenetic clades of Fusarium verticillioides that were characterized by sequencing a region of the beta-tubulin gene. Terbinafine was the most-active drug against both species, followed by posaconazole against F. verticillioides.
Azor
Mónica
M
Unitat de Microbiologia, Facultat de Medicina i Ciències de Salut, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
Gené
Josepa
J
Cano
Josep
J
Sutton
Deanna A
DA
Fothergill
Annette W
AW
Rinaldi
Michael G
MG
Guarro
Josep
J
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D005670:Fusarium / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009181:Mycoses / Q000382:microbiology*; D009281:Naphthalenes / Q000494:pharmacology; D017422:Sequence Analysis, DNA; D000077291:Terbinafine; D014230:Triazoles / Q000494:pharmacology; D014404:Tubulin / Q000235:genetics*
D000935:Antifungal Agents; D009281:Naphthalenes; D014230:Triazoles; D014404:Tubulin; C101425:posaconazole; D000077291:Terbinafine