Hemodynamic improvement of acutely decompensated heart failure patients is associated with decreasing levels of NT-proBNP.
BACKGROUND
Successful therapy in chronic clinically stable heart failure is reflected by decreasing serum NT-proBNP levels. This study evaluates therapy monitoring by NT-proBNP in comparison to invasively measured hemodynamic parameters in acutely decompensated heart failure patients.


RESULTS
In 25 acutely decompensated chronic heart failure patients (NYHA III-IV, Cardiac Index (CI)<or=2.5 l/min/m(2) and a PCWP>or=15 mm Hg) changes in NT-proBNP and invasive hemodynamics were compared. Hemodynamic improvement in the first 24 h (CI>or=30% and PCWP<or=30%, compared to baseline) was associated with decreasing NT-proBNP levels; which was not seen in patients without hemodynamic improvement. To discriminate between responders and non-responders, a decline to <80% of the baseline NT-proBNP in the first 24 h was the best cut-off.


CONCLUSIONS
Hemodynamic improvement in acutely decompensated heart failure patients is associated with decreasing NT-proBNP levels.
Knebel
Fabian
F
Schimke
Ingolf
I
Diaz Ramirez
Ivan
I
Schattke
Sebastian
S
Eddicks
Stephan
S
Borges
Adrian C
AC
Baumann
Gert
G
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain