title: TAFI antigen level variability in young healthy Asian Indians; first report from Asia.
abstract: Thrombin Activatable Fibrinolytic Inhibitor (TAFI) is a plasma protein, which inhibits fibrinolysis by removing carboxyterminal lysine residues from partially degraded fibrin thereby decreasing plasminogen binding on its surface. In this study we have investigated the antigenic level variability (Inter and Intraindividual) of Thrombin Activatable Fibrinolysis Inhibitor in 120 healthy Asian Indians since no data on this is available regarding this population. TAFI antigen levels did not show a normal distribution in our population (p<0.001). Median TAFI antigen levels were found to be 11.683 microg/ml. It ranged from 33.9-202.5%of normal pool plasma (3.9-23.5 microg/ml). TAFI antigenic level showed high level of variability in the Indian population (coefficient of variation: 37.4%). TAFI antigenic levels were stable intraindividually (p=0.218).
authors.affiliation: Department of Hematology, AIIMS, New Delhi, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Biswas
authors.forename: Ravi
authors.initials: R
authors.lastname: Ranjan
authors.forename: Arvind
authors.initials: A
authors.lastname: Meena
authors.forename: Suhail
authors.initials: S
authors.lastname: Akhter
authors.forename: Noemie
authors.initials: N
authors.lastname: Saut
authors.forename: Corinne
authors.initials: C
authors.lastname: Frere
authors.forename: Irene Juhan
authors.initials: IJ
authors.lastname: Vague
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Shukla
authors.forename: Madhuri
authors.initials: M
authors.lastname: Behari
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D025901:Carboxypeptidase B2 / Q000097:blood* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007194:India; D008297:Male
chemical_list: D025901:Carboxypeptidase B2