Potato and soy peptide diets modulate lipid metabolism in rats.
Dietary plant and animal peptides have been shown to reduce serum lipids. However, the potential of food-derived peptides has yet to be fully elucidated. We investigated the physiological importance of potato peptides in rats fed on a cholesterol-free diet containing 20% potato peptides (PP), when compared with two diets containing either 20% casein (CN) or 20% soy peptides (SP). The high-density lipoprotein (HDL)-cholesterol (+13.8%) and serum triglyceride (-38%) concentrations in the PP-fed group, non-HDL-cholesterol level in the PP- (-22.5%) and SP- (-15.7%) fed groups, and serum total cholesterol concentration (-12%) in the SP-fed group, were significantly different from the control group at the end of the experiment. The fecal excretion of neutral and acidic sterols was higher in the PP- and SP-fed groups, respectively, relative to the control group. These results indicate that the observed changes in the serum cholesterol levels in rats fed on soy and potato peptide appear to have been due to different mechanisms.
Liyanage
Ruvini
R
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
Han
Kyu-Ho
KH
Watanabe
Shoko
S
Shimada
Ken-ichiro
K
Sekikawa
Mitsuo
M
Ohba
Kiyoshi
K
Tokuji
Yoshihiko
Y
Ohnishi
Masao
M
Shibayama
Shinichi
S
Nakamori
Toshihiro
T
Fukushima
Michihiro
M
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D004032:Diet; D005243:Feces; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D011198:Solanum tuberosum / Q000737:chemistry*; D030262:Soybean Proteins / Q000494:pharmacology*; D013261:Sterols / Q000378:metabolism
D001647:Bile Acids and Salts; D008055:Lipids; D012333:RNA, Messenger; D030262:Soybean Proteins; D013261:Sterols