Innate immune 'self' recognition: a role for CD47-SIRPalpha interactions in hematopoietic stem cell transplantation.
Self-nonself discrimination is a central property of the immune system. This paradigm was originally established in the context of tissue transplantation, leading to the discovery of major histocompatibility complex molecules as signals of 'self'. However, accumulating evidence has shown that innate immune cells are regulated in a similar fashion. Recent evidence has suggested that interactions between the 'self' molecule CD47 and the innate inhibitory receptor signal regulatory protein-alpha expressed on macrophages may be a critical determinant of transplant engraftment, supporting the concept that 'self'-awareness is a general property of all immune cells.
van den Berg
Timo K
TK
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, 1066 CX Amsterdam, The Netherlands. t.k.vandenberg@sanquin.nl
van der Schoot
C Ellen
CE
D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051928:CD47 Antigen / Q000276:immunology / Q000378:metabolism*; D025461:Feedback, Physiological / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D023461:Myeloid Progenitor Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D011110:Polymorphism, Genetic / Q000276:immunology; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D017634:Self Tolerance; D015398:Signal Transduction; D014181:Transplantation Immunology; D023001:Transplantation Tolerance; D014183:Transplantation, Heterologous / Q000276:immunology
D000943:Antigens, Differentiation; D051928:CD47 Antigen; D011971:Receptors, Immunologic; C501920:SIRPA protein, human