title: No greater incidence or worsening of cardiac valve regurgitation with somatostatin analog treatment of acromegaly.
abstract: BACKGROUND
  Excess GH and IGF-I in acromegaly are associated with reduced life expectancy due to cardiovascular complications.
  
  
  OBJECTIVE
  The objective of the study was to investigate the prevalence, incidence, and severity of cardiac valve regurgitation before and after somatostatin-analog treatment in acromegaly.
  
  
  METHODS
  This was a prospective, observer-blinded, multicenter, 12-month study.
  
  
  METHODS
  The study was conducted at 33 specialist centers.
  
  
  METHODS
  The study population consisted of 225 adult patients with acromegaly without significant cardiac valve abnormalities or prior valve-replacement surgery, matched for age, sex, and center/country/study.
  
  
  METHODS
  Interventions included initiation/continuation of lanreotide (n = 107) or octreotide treatment (n = 118), tailored for optimal disease control.
  
  
  METHODS
  Relative risk of new/worsening regurgitation in any valve at 12 months compared with baseline, was measured.
  
  
  RESULTS
  At baseline, almost 80% of patients had some degree of cardiac valve regurgitation, although none was severe. The risk of developing new/worsening regurgitation in any valve at 12 months was nonsignificant and similar for the cohorts [adjusted odds ratio 0.86; 95% confidence interval (CI) 0.41-1.82; P = 0.694; relative risk 1.04; 95% CI 0.67-1.60; risk difference 0.01; 95% CI -0.13 to 0.16]. For 54% of patients, the severity of regurgitation stayed the same during the study. At baseline, significant valve regurgitation occurred in 18% of patients (lanreotide cohort) and 13% (octreotide cohort) and at 12 months in 18% of each cohort.
  
  
  CONCLUSIONS
  The incidence of valve regurgitation did not change over 12 months of treatment with somatostatin analogs, and most cases were physiologic or mild in severity. There was no significant difference between somatostatin analogs in the risk of developing new/worsening valve regurgitation or significant regurgitation after 1 yr.
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, via S. Pansini 5, Naples, Italy. colao@unina.it
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Josef
authors.initials: J
authors.lastname: Marek
authors.forename: Miklos I
authors.initials: MI
authors.lastname: Goth
authors.forename: Philippe
authors.initials: P
authors.lastname: Caron
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Kuhn
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Minuto
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Weissman
mesh_terms: D000172:Acromegaly / Q000188:drug therapy* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000139:chemically induced* / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D006351:Heart Valves / Q000473:pathology; D006801:Humans; D016555:Matched-Pair Analysis; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013004:Somatostatin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin; D015282:Octreotide