Influence of thyroid hormones on the GH-IGF-I axis.
There is a complex relationship between thyroid hormones, GH, and the insulin-like growth factors (IGFs). Thyroid hormones act at many sites from the hypothalamic control of GH release to the tissue expression of IGF-I and its binding proteins (IGFBPs). In this review, we present current knowledge of the effects of altered thyroid status on the GH-IGF-I axis, concentrating on the changes seen in IGF-I gene expression and circulating levels of GH and IGFBPs.
Rodriguez-Arnao
J
J
Deparmtent of Endocrinology, St Bartholomew s Hospital, London EC 17EB, England.
Miell
J P
JP
Ross
R J
RJ