title: Deep brain stimulation in Tourette's Syndrome.
abstract: Tourette's Syndrome (TS) is a neuropsychiatric disorder characterized by motor and vocal tics, often associated with behavioral disorders. Symptoms often disappear before or during adulthood. The pathophysiology of TS is still a matter of considerable debate. Current knowledge of cortico-basal ganglia-thalamocortical circuits provide explanations for the beneficial effects of deep brain stimulation (DBS) on tics. When conservative treatment fails in patients with severe TS, DBS may be a therapeutic option. In 1999, thalamic DBS was introduced for intractable TS. Since then, multiple targets have been used in a small number of patients, including the globus pallidus pars interna and the nucleus accumbens. Inclusion and exclusion criteria have been formulated to identify good candidates for DBS.
authors.affiliation: Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands.
authors.forename: Linda
authors.initials: L
authors.lastname: Ackermans
authors.forename: Yasin
authors.initials: Y
authors.lastname: Temel
authors.forename: Veerle
authors.initials: V
authors.lastname: Visser-Vandewalle
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D005879:Tourette Syndrome / Q000628:therapy*