Statistical evaluation of genetic footprinting data.
As transposomics is extended to genome scale, appropriate statistical methods need to be developed to assign significance to gene essentiality. In this chapter, the author presents a set of steps that, together with genome-scale insertion data and the complete genome sequence of a prokaryote, can be used to classify the genes of the organism as either "essential" or "nonessential."
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Department of Systems Biology-Unit 950, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
D018983:DNA Footprinting / Q000379:methods*; D005798:Genes, Bacterial; D020043:Genes, Essential; D016680:Genome, Bacterial; D015233:Models, Statistical