title: New strategies for the synthesis of pyrimidine derivatives.
abstract: Recent advances in pyrimidine synthesis are described. Modification of conventional strategies involving N-C-N fragment condensation with 1,3-dicarbonyl derivatives remains a common theme in current literature. Other methods, including N-C fragment condensation strategies, provide reactive intermediates capable of intramolecular cyclization and formation of pyrimidine derivatives. These recently developed methodologies offer a valuable addendum to azaheterocycle synthesis.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hill
authors.forename: Mohammad
authors.initials: M
authors.lastname: Movassaghi
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry; D000812:Anhydrides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D017606:Chlorine Compounds / Q000737:chemistry; D004951:Esterification; D017611:Fluorine Compounds / Q000737:chemistry; D008697:Methane / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000577:Amides; D000812:Anhydrides; D002264:Carboxylic Acids; D017606:Chlorine Compounds; D017611:Fluorine Compounds; D011743:Pyrimidines; D013457:Sulfur Compounds; D014753:Vinyl Compounds; D002244:Carbon; C030986:pyrimidine; D009584:Nitrogen; D008697:Methane