Gene regulation: hacking the network on a sugar high.
In a recent issue of Molecular Cell, Kaplan et al. (2008) determine the input functions for 19 E. coli sugar-utilization genes by using a two-dimensional high-throughput approach. The resulting input-function map reveals that gene network regulation follows non-Boolean, and often nonmonotonic, logic.
Ellis
Tom
T
Center for BioDynamics, Boston University, 44 Cummington Street, Boston, MA 02115, USA.
Wang
Xiao
X
Collins
James J
JJ
D002241:Carbohydrates; D000242:Cyclic AMP / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D017930:Genes, Reporter; D008128:Logic; D011401:Promoter Regions, Genetic
D002241:Carbohydrates; D000242:Cyclic AMP