P bodies, stress granules, and viral life cycles.
Eukaryotic mRNAs are in a dynamic equilibrium between different subcellular locations. Translating mRNAs can be found in polysomes, mRNAs stalled in translation initiation accumulate in stress granules and mRNAs targeted for degradation or translation repression can accumulate in P bodies. Partitioning of mRNAs between polysomes, stress granules, and P bodies affects rates of translation and mRNA degradation. Host proteins within P bodies and stress granules can enhance or limit viral infection, and some viral RNAs and proteins accumulate in P bodies and/or stress granules. Thus, an important interplay among P bodies, stress granules, and viral life cycles is beginning to emerge.
Beckham
Carla J
CJ
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85721-0206, USA.
Parker
Roy
R
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism*; D022083:Cytoplasmic Structures / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology* / Q000821:virology; D006801:Humans; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D020871:RNA Stability; D012327:RNA Virus Infections / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D012328:RNA Viruses / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism
D011506:Proteins; D012333:RNA, Messenger; D012367:RNA, Viral