Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.
We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
Pascu
Sofia I
SI
Chemistry Department, University of Bath, Claverton Down, UKBA2 7AY. s.pascu@bath.ac.uk
Waghorn
Philip A
PA
Conry
Timothy D
TD
Lin
Bonita
B
Betts
Helen M
HM
Dilworth
Jonathan R
JR
Sim
Robert B
RB
Churchill
Grant C
GC
Aigbirhio
Franklin I
FI
Warren
John E
JE
D017209:Apoptosis / Q000187:drug effects; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013882:Thiosemicarbazones / Q000737:chemistry*; D018675:Toxicity Tests; D015032:Zinc / Q000737:chemistry*
D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D015032:Zinc