Multifocal extranodal non-Hodgkin lymphoma involving both the lungs and brain in a child with primary immunodeficiency.
Immunodeficiency is associated with increased susceptibility to infections and B-cell lymphoproliferative disorders, which range from polyclonal proliferations to monoclonal lymphomas. In primary immunodeficiencies, the true incidence of lymphoproliferative disorders has been estimated between 1.4% and 24%. Recurrent or chronic infections resulting in continuous antigen exposure result in abnormal B-cell proliferation and ultimately lymphoma. Immunosuppression leads to increase in likelihood of Epstein-Barr virus-associated malignancies. We report a case of the child with multifocal extranodal non-Hodgkin lymphoma involving both the lungs and brain in a case of primary immunodeficiency.
Bal
Amanjit
A
Department of Histopathology, PGIMER, Chandigarh, India. docaman5@hotmail.com
Gupta
Anju
A
Sodhi
Kushaljit Singh
KS
Das
Ashim
A
Singh
Surjit
S
D001344:Autopsy; D001932:Brain Neoplasms / Q000473:pathology*; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008175:Lung Neoplasms / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*