title: Contralateral intratubular germ cell neoplasia in a patient with testicular cancer.
abstract: BACKGROUND
  A 27-year-old man was referred to an oncology department following right orchiectomy for a stage I testicular seminoma at high risk for recurrence. He presented 6 weeks after the orchiectomy with an atrophic left testis, fatigue and a history of infertility.
  
  
  METHODS
  Measurement of serum levels of urea, electrolytes, liver enzymes, bilirubin, human chorionic gonadotropin, alpha-fetoprotein, lactate dehydrogenase, testosterone and luteinizing hormone, full blood count, and left testicular biopsy.
  
  
  METHODS
  Tubular atrophy of the left testis with islands of intratubular germ cell neoplasia (ITGCN), and hypergonadotropic hypogonadism.
  
  
  RESULTS
  The patient received adjuvant chemotherapy as a single dose of carboplatin for the seminoma at high risk for recurrence, and testosterone replacement for the hypergonadotropic hypogonadism. Radiotherapy to the ITGCN-bearing solitary testis or a second orchiectomy was offered to prevent the progression of ITGCN into an invasive germ cell tumor. After exploring his options with regards to fertility treatment, the patient chose to undergo second orchiectomy with a subsequent, unsuccessful, attempt at sperm retrieval. At 20 months after diagnosis of his initial seminoma the patient showed no sign of recurrence.
authors.affiliation: Department of Oncology, Thomayer University Hospital, Prague, Czech Republic. tomas.buchler@ftn.cz
authors.forename: Tomas
authors.initials: T
authors.lastname: Buchler
authors.forename: Alex
authors.initials: A
authors.lastname: Freeman
authors.forename: Stephen
authors.initials: S
authors.lastname: Harland
mesh_terms: D000328:Adult; D000728:Androgens / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001284:Atrophy; D016190:Carboplatin / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000628:therapy; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D009919:Orchiectomy; D012671:Seminiferous Tubules / Q000473:pathology*; D018239:Seminoma / Q000473:pathology* / Q000601:surgery; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery; D013737:Testis / Q000473:pathology / Q000601:surgery; D013739:Testosterone / Q000627:therapeutic use
chemical_list: D000728:Androgens; D000970:Antineoplastic Agents; D013739:Testosterone; D016190:Carboplatin