title: Management of patients with treatment-resistant depression.
abstract: Treatment-resistant depression can be attributed to multiple causes, including nonadherence to medication and medical and psychiatric comorbidities. Selecting the appropriate strategy for a patient with treatment-resistant depression, whether it be a single antidepressant, a combination of medications, or a nonpharmacologic method, depends on a correct determination of the cause of the patient's resistance to treatment.
authors.affiliation: Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pa., USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012307:Risk Factors
chemical_list: D000928:Antidepressive Agents