title: Enantioselective synthesis of iridal, the parent molecule of the iridal triterpenoid class.
abstract: The monocyclic triterpene iridal 1 (parent molecule) is synthesized by an approach that allows access for several representatives of the iridal family as well as diversely substituted analogues. The success of the proposed synthetic plan depends upon the effortless stereoselective establishment of the trans C10/C11 dimethyl relationship in B-ring moiety 7 using a domino-based methodology and the higly efficient Miyaura-Suzuki type sp3-sp2 segment coupling 7 and 8, respectively.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
authors.forename: Andrei
authors.initials: A
authors.lastname: Corbu
authors.forename: Maurizio
authors.initials: M
authors.lastname: Aquino
authors.forename: T V
authors.initials: TV
authors.lastname: Pratap
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Siméon
authors.initials: S
authors.lastname: Arseniyadis
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014315:Triterpenes; C473636:iridal; D010165:Palladium