Cutaneous ultraviolet exposure and its relationship to the development of skin cancer.
Skin cancer is becoming an increasingly important public health problem. Multiple studies have now demonstrated a relationship between ultraviolet exposure and increased risk of developing skin cancer. However, the specifics of that association are somewhat different for malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. A better understanding of the mechanisms that allow cutaneous ultraviolet radiation to induce neoplasia will result in the development of better future sun-protection agents and strategies.
Rigel
Darrell S
DS
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. dsrigel@alum.mit.edu
D001315:Australia / Q000453:epidemiology; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D018570:Risk Assessment; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D013472:Sunlight / Q000009:adverse effects*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology