Structural determination and proposed biosynthesis of alcanivorone, a novel alpha-pyrone produced by Alcanivorax jadensis.
A novel alpha-pyrone designated as alcanivorone was found in a culture broth of the marine bacterium, Alcanivorax jadensis, and its structure was determined by an analysis of 1D NMR, 2D NMR and MS data. Alcanivorone was produced by A. jadensis only when sodium pyruvate was added to the culture medium as a carbon source. Incorporation experiments using stable isotope-labeled pyruvate indicated that alcanivorone was biosynthesized from four molecules of pyruvate.
Kanoh
Kaneo
K
Marine Biotechnology Institute Co. Ltd, Heita, kamaishi, Iwate, Japan. kaneo.kanoh@mbio.jp
Adachi
Kyoko
K
Katsuta
Atsuko
A
Shizuri
Yoshikazu
Y
D053521:Alcanivoraceae / Q000378:metabolism*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
D000890:Anti-Infective Agents; D011753:Pyrones; C529997:alcanivorone