[The role of dopamine D3 receptor in the amphetamine-induced conditioned place preference in mice].
OBJECTIVE
To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice.


METHODS
The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software.


RESULTS
D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice.


CONCLUSIONS
The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.
Zhu
Jun-Yan
JY
Department of Forensic Medicine, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. zhujunyan@163.com
Chen
Li-Ping
LP
Li
Lin
L
Zheng
Hai-Bo
HB
Chen
Teng
T
D000661:Amphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D055786:Gene Knockout Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D011930:Reaction Time; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*
D050637:Receptors, Dopamine D3; D000661:Amphetamine