Pathology of inverted Takotsubo cardiomyopathy.
Myocardial dysfunction without coronary involvement may occur in acute cerebral diseases. The inverted Takotsubo pattern has been recently recognized as a novel heart neurologic stress-related syndrome. We report on the case of a 40-year-old woman presenting with massive subarachnoid hemorrhage and brain death. Echocardiography revealed an extensive left ventricular circumferential akinesis except at the apex. Histologic analysis of the heart confirmed the absence of myocardial infarction and revealed only sparse foci of myocyte necrosis with contraction bands in the akinetic areas.
Maréchaux
Sylvestre
S
Echocardiography and Physiology Laboratories, Lille Medical University Center, Lille, France. sylvestre.marechaux@yahoo.fr
Fornes
Paul
P
Petit
Stéphanie
S
Poisson
Catherine
C
Thevenin
Didier
D
Le Tourneau
Thierry
T
Asseman
Philippe
P
Bruneval
Patrick
P
Ennezat
Pierre-Vladimir
PV
D000328:Adult; D001926:Brain Death; D004452:Echocardiography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009206:Myocardium / Q000473:pathology; D009336:Necrosis / Q000473:pathology; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000473:pathology; D054549:Takotsubo Cardiomyopathy / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000473:pathology* / Q000503:physiopathology