Phytotherapeutic inhibition of supragingival dental plaque.
Antimicrobial activities and biofilm-formation preventive properties of Mentha piperita and Cuminum cyminum essential oils and chlorhexidine were assessed against Streptococcus mutans and Streptococcus pyogenes. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analysis led to the identification of 26 and 32 compounds in the essential oils of M. piperita and C. cyminum, respectively. Minimal bactericidal concentrations (MBC) of the oils and chlorhexidine and microbial decimal reduction time (D value) were determined. Antibacterial and in vivo biofilm preventive efficacies of all the concentrations of M. piperita oil were significantly (p<0.001) higher. The biofilm inhibitory properties in planktonic cultures were in M. piperita > chlorhexidine > C. cyminum order. In vivo experiments conducted on male and female volunteers who brushed with essential oil blended toothpastes indicated that lower concentrations of the oils, in particular the M. piperita oil, were significantly higher (p<0.001) and effective during the course of the study as compared to chlorhexidine. In conclusion, there may be a potential role for essential oils in the development of novel anticaries treatments.
Shayegh
Shojaedin
S
Department of prosthetics, College of Dentistry, Shahed University, Tehran, Iran.
Rasooli
Iraj
I
Taghizadeh
Massoud
M
Astaneh
Shakiba Darvish Alipoor
SD
D000328:Adult; D001422:Bacterial Adhesion / Q000187:drug effects; D028527:Cuminum / Q000737:chemistry*; D003773:Dental Plaque / Q000382:microbiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D036142:Mentha piperita / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development
D010938:Plant Oils