title: Clinical staging and histopathological findings after radical hysterectomy in FIGO stage IIB cervical cancer.
abstract: OBJECTIVE
  Advanced cervical cancer still represents a major health care challenge in the developing world. According to standard protocols the treatment of choice for stage IIB cervical cancer is cisplatin-based chemoradiotherapy. However, in some European countries, and especially in Japan, patients with stage IIB cervical cancer are generally treated with radical hysterectomy as initial treatment. The aim of this study was to compare clinical stage with pathological findings, and also to correlate any relationship between parametrial infiltration and nodal status.
  
  
  METHODS
  From 1997 to 2006, 26 patients with FIGO stage IIB cervical cancer were radically operated (Piver class III operation). Preoperative clinical findings were compared with the pathological findings of the surgical material. The correlation between infiltration of the parametria and lymph node status was also examined. Fisher's exact test was used to examine statistical significance.
  
  
  RESULTS
  The patients' median age was 48.3 years (range 36-61). The median number of removed lymph nodes was 16 (range 8-40). The histopathological types of cervical tumors were: squamous cell carcinoma 80%, adenosquamous carcinoma 15% and adenocarcinoma 5%. In 50% of the patients the parametria were infiltrated, suggesting that 50% of the patients were clinically overstaged. Positive lymph nodes were found in 69% of patients with positive parametria and 15% in patients with negative parametria (p <0.05). Patients with positive lymph nodes received adjuvant chemoradiotherapy.
  
  
  CONCLUSIONS
  Adequate preoperative staging such as clinical examination under anesthesia or nuclear magnetic resonance could help to exclude parametrial involvement in equivocal cases. Parametrial invasion presents an important risk factor for lymph nodes metastases.
authors.affiliation: Institute of Oncology Vojvodina, Sremska Kamenica, Serbia. aljosa.m@eunet.yu
authors.forename: A
authors.initials: A
authors.lastname: Mandic
authors.forename: P
authors.initials: P
authors.lastname: Novakovic
authors.forename: O
authors.initials: O
authors.lastname: Mihajlovic
authors.forename: B
authors.initials: B
authors.lastname: Stojiljkovic
authors.forename: J
authors.initials: J
authors.lastname: Rajovic
authors.forename: M
authors.initials: M
authors.lastname: Davidovic
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery