title: [Distribution of tryptophan hydroxylase gene-T457C locus polymorphism in Han ethnic group in northern China].
abstract: OBJECTIVE
  To study the distribution of the tryptophan hydroxylase (TPH) gene-T457C locus polymorphism in Han ethnic group in northern China and to find its applicable value in forensic science.
  
  
  METHODS
  Genomic DNA samples, extracted from 180 unrelated individuals in northern Chinese Han population, were analyzed by PCR-RFLP.
  
  
  RESULTS
  The discrimination power (DP) value and the power of exclusion (PE) value of the TPH gene-T457C locus were 0.624 and 0.187, respectively. The allele frequency showed significant difference from that of French people (P=0.04).
  
  
  CONCLUSIONS
  Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. It has a potential to be used in forensic science.
authors.affiliation: School of Forensic Medicine, China Medical University, Shenyang, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Guan
authors.forename: Bao-Jie
authors.initials: BJ
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Ding
authors.forename: Hao
authors.initials: H
authors.lastname: Pang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Lu
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Xing
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Yi
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D014365:Tryptophan Hydroxylase