title: MDCT angiography for detection of pulmonary emboli: comparison between equi-iodine doses of iomeprol 400 mgI/mL and iodixanol 320 mgI/mL.
abstract: OBJECTIVE
  To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism.
  
  
  METHODS
  Eighty randomized subjects received equi-iodine intravenous doses (48 g) of iomeprol 400 (n=40) or iodixanol 320 (n=40), via power injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation.
  
  
  RESULTS
  There were no between-group differences (p>0.05) in demographics. Pulmonary artery attenuation was significantly (p<or=0.03) higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted.
  
  
  CONCLUSIONS
  The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.
authors.affiliation: Department of Radiology, Vienna General Hospital, Medical University, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Herbert.langenberger@meduniwien.ac.at
authors.forename: Herbert
authors.initials: H
authors.lastname: Langenberger
authors.forename: Klaus
authors.initials: K
authors.lastname: Friedrich
authors.forename: Christina
authors.initials: C
authors.lastname: Plank
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Matzek
authors.forename: Florian
authors.initials: F
authors.lastname: Wolf
authors.forename: Maria Luigia
authors.initials: ML
authors.lastname: Storto
authors.forename: Cornelia
authors.initials: C
authors.lastname: Schaefer-Prokop
authors.forename: Christian
authors.initials: C
authors.lastname: Herold
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014283:Triiodobenzoic Acids / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C057937:iomeprol; C044834:iodixanol; D007479:Iopamidol