AR, apoE, and cognitive function.
Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by epsilon4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.
Raber
Jacob
J
Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. raberj@ohsu.edu
D000368:Aged; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D000728:Androgens / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000502:physiology*; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000502:physiology*; D012307:Risk Factors; D012727:Sex Characteristics; D013739:Testosterone / Q000378:metabolism
D000728:Androgens; D001057:Apolipoproteins E; D011944:Receptors, Androgen; D013739:Testosterone