Pregnancy in a hermaphrodite with a male-predominant mosaic karyotype.
OBJECTIVE
To report a pregnancy in a hermaphrodite and review of the literature.


METHODS
Case report and literature review.


METHODS
Clinical.


METHODS
A patient with male-predominant mosaic karyotype 96% 46XY.


METHODS
Removal of left ovotestis in combination with a supracervical hysterectomy and bilateral salpingo-oophorectomy.


METHODS
Identification of published cases of pregnancy and hermaphroditism.


RESULTS
The current patient had previous pregnancy and a wedge biopsy of her left gonad, which demonstrated an ovotestis and an area suspicious for a gonadoblastoma. After delivery of her second pregnancy, the patient underwent a hysterectomy and bilateral salpingo-oophorectomy. The histopathologic evaluation following bilateral oophorectomy demonstrated a residual ovotestis without further evidence of a gonadoblastoma. Review of the literature identified 10 other cases of pregnancy in a hermaphrodite patient.


CONCLUSIONS
This is the 11th reported case of fertility in a true hermaphrodite and only the second report of a mosaic true hermaphrodite to demonstrate fertility. This is the only case of a pregnancy involving a male-predominant mosaic 96% 46XY and the only case to confirm the genetics of the offspring.
Schoenhaus
Samantha A
SA
Kaiser Permanente Southern California, West Los Angeles and Los Angeles Medical Centers, Los Angeles, California 90034, USA.
Lentz
Scott E
SE
Saber
Peter
P
Munro
Malcom G
MG
Kivnick
Seth
S
D000328:Adult; D005260:Female; D005298:Fertility; D006060:Gonadal Dysgenesis, Mixed / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D018238:Gonadoblastoma / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy; D007621:Karyotyping; D010535:Laparoscopy; D050498:Live Birth; D008297:Male; D009030:Mosaicism; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D010052:Ovariectomy; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D050090:Ovotesticular Disorders of Sex Development / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D013736:Testicular Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D013737:Testis / Q000473:pathology* / Q000601:surgery