[Toll-like receptor in lung response to pathogens].
Innate immunity plays a central role in antimicrobial defense. Advances in the understanding of pathogen recognition systems of innate cells have yielded the identification of Toll like receptors (TLR) as key elements of the lung defense mechanisms which is heavily exposed to a variety of stimuli. TLR recognition of several microbial compounds induces proinflammatory cytokines production whose contribution to the host may be either protective or detrimental. Human immune response diversity may explain the differences observed between patients facing bacterial, viral and fungal lung infections. New strategies designs that modify innate immune response may be useful to limit detrimental consequences of inflammatory processes in the lung.
Rivas-Santiago
Bruno
B
Unidad de Investigación Médica-Zacatecas, IMSS, Departamento de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Juárez
Esmeralda
E
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D008168:Lung / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology / Q000821:virology; D016676:Macrophages, Alveolar / Q000502:physiology; D008322:Mammals; D011014:Pneumonia / Q000276:immunology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D012130:Respiratory Hypersensitivity / Q000503:physiopathology; D051198:Toll-Like Receptor 5 / Q000502:physiology; D051193:Toll-Like Receptors / Q000235:genetics / Q000502:physiology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; D029721:Drosophila Proteins; C068721:Tl protein, Drosophila; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; C495341:tehao protein, Drosophila