HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004.
We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.
Chakraborty
Rana
R
Paediatric Infectious Diseases Unit, St. George's Hospital, London. rchakrab@sgul.ac.uk
Smith
Colette J
CJ
Dunn
David
D
Green
Hannah
H
Duong
Trinh
T
Doerholt
Katja
K
Riordon
Andrew
A
Lyall
Hermione
H
Tookey
Pat
P
Butler
Karina
K
Sabin
Caroline A
CA
Gibb
Di
D
Pillay
Deenan
D
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D020125:Mutation, Missense; D006113:United Kingdom