Methamphetamine induces chronic corticostriatal depression: too much of a bad thing.
Leading theories of drug addiction propose that repeated drug exposure produces a long-lasting homeostatic dysregulation in brain reward processing that is normalized by drug readministration. In this issue of Neuron, Bamford and colleagues describe a novel neurobiological substrate that may contribute to this effect.
Day
Jeremy J
JJ
Department of Psychology, University of North Carolina at Chapel Hill, CB# 3270, Davie Hall, Chapel Hill, NC 27599-3270, USA.
Carelli
Regina M
RM
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000187:drug effects* / Q000502:physiology; D008694:Methamphetamine / Q000009:adverse effects* / Q000494:pharmacology*; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology
D008694:Methamphetamine