title: Investigations concerning the correlation of COX-1 inhibitory and hydroxyl radical scavenging activity.
abstract: The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.
authors.affiliation: Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg-University, Mainz, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Scholz
authors.forename: Holger
authors.initials: H
authors.lastname: Ulbrich
authors.forename: Andreas
authors.initials: A
authors.lastname: Mattern
authors.forename: Jan-Peter
authors.initials: JP
authors.lastname: Kramb
authors.forename: Werner
authors.initials: W
authors.lastname: Kiefer
authors.forename: Gerd
authors.initials: G
authors.lastname: Dannhardt
mesh_terms: D000818:Animals; D002417:Cattle; D051545:Cyclooxygenase 1 / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D016861:Cyclooxygenase Inhibitors; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D051545:Cyclooxygenase 1