Serum levels of S100B are decreased in chronic starvation and normalize with weight gain.
S100B protein is mainly synthesized in glial cells and modulates the balance between cell proliferation and differentiation in neurons and glial cells. However, S100B is not CNS-specific since its production was detected in numerous non-cerebral tissues e.g. adipocytes. In this study we investigated the influence of chronic fasting and subsequent weight gain on serum levels of S100B in patients with anorexia nervosa. We found that nutritional status was an important factor influencing serum levels of S100B.
Holtkamp
Kristian
K
Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. kholtkamp@ukaachen.de
Bühren
Katharina
K
Ponath
Gerald
G
von Eiff
Christoph
C
Herpertz-Dahlmann
Beate
B
Hebebrand
Johannes
J
Rothermundt
Matthias
M
D000293:Adolescent; D000367:Age Factors; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D002908:Chronic Disease; D004044:Dietary Proteins; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D009414:Nerve Growth Factors / Q000097:blood*; D009752:Nutritional Status; D011237:Predictive Value of Tests; D020127:Recovery of Function / Q000502:physiology; D012016:Reference Values; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013217:Starvation / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D015430:Weight Gain / Q000502:physiology
D015415:Biomarkers; D004044:Dietary Proteins; D020738:Leptin; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human