A study on nephropathy in type 2 diabetes mellitus: histology and its correlation with clinical and biochemical parameters.
To document clinical, serum and urinary parameters in patients with features of diabetic nephropathy in type 2 diabetes mellitus and to correlate light microscopical findings of the renal biopsy specimen with the clinical, serum and urinary parameters, a study was conducted among 30 patients of type 2 diabetes mellitus with features of nephropathy attended Medical College, Kolkata with special emphasis given on neurological and fundoscopic examination. The patients were investigated with fasting and postprandial venous plasma glucose, glycosylated haemoglobin (HbA1c), serum urea, creatinine, sodium, potassium, 24-hour urinary protein/micro-albumin and lipid profile. Percutaneous renal biopsy was performed after taking informed consent from the patients and sent for histopathological examination. Obtained data were tabulated and analysed. Among 30 patients (male-16; female-14; proteinuric-23, micro-albuminuric-6) diabetic nephropathy was detected in 28 patients (diffuse-15, nodular-9, 4 had focal segmental glomerulosclerosis) and 2 had normal renal biopsy. Retinopathy was detected in 16 patients; 12 had autonomic neuropathy and 3 had peripheral neuropathy.
Bhattacharya
Sanjoy
S
Department of Medicine, Medical College, Kolkata.
Mandal
Sanjay Kumar
SK
Bandyopadhyay
Ramtanu
R
Chakrabarti
Srabani
S
Basu
Ashis Kumar
AK
Pal
Subrata
S
D000328:Adult; D000419:Albuminuria; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D003930:Diabetic Retinopathy; D018450:Disease Progression; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D012307:Risk Factors