title: Post-hepatectomy regeneration of the murine liver I. Effect upon Schistosoma mansoni lesions, before and after chemotherapy.
abstract: Hepatic histopathological changes due to Schistosoma mansoni infection in the mouse presented considerable improvement following partial hepatectomy, both during early (acute) and late (chronic) infections, and especially when surgery was preceded by curative chemotherapy. A 60% hepatectomy removed a great deal of a diseased liver that was replaced by a normal-looking tissue in which schistosomal lesions appeared fewer and scattered. After chemotherapy, residual fibrosis left either from cured acute and chronic schistosomal lesions, almost completely disappeared when the regenerated liver was examined a month afterwards. These marked changes, brought about by hepatectomy in experimental hepatic schistosomiasis, illustrate the fact that post-hepatectomy regeneration tends to restore the normal structure of the liver, even in a diseased organ.
authors.affiliation: FIOCRUZ, Centro de Pesquisas René Rachou, av. Augusto de Lima 1766, Belo Horizonte, MG, Brazil.
authors.forename: Paulo Marcos Zech
authors.initials: PM
authors.lastname: Coelho
authors.forename: Zilton A
authors.initials: ZA
authors.lastname: Andrade
authors.forename: Rômulo Teixeira
authors.initials: RT
authors.lastname: de Mello
authors.forename: Guilherme
authors.initials: G
authors.lastname: Costa
authors.forename: Flávia Sílvia Guimarães
authors.initials: FS
authors.lastname: Dias
authors.forename: José Renan
authors.initials: JR
authors.lastname: Cunha-Melo
mesh_terms: D000818:Animals; D004358:Drug Therapy; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008115:Liver Regeneration; D051379:Mice; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000601:surgery*; D016896:Treatment Outcome