[Development of new methods of magnetic resonance for the characterization of oxygenation and perfusion of tumors. Diagnostic and therapeutic applications].
Tumor hypoxia is a key factor of the tumor growth and response to therapy. In this short note, we describe our recent contribution to the development of new non-invasive methods for measuring tumor oxygenation and perfusion by magnetic resonance techniques (NMR and EPR). After validation, these techniques have been applied to study the influence of physiological and pharmacological factors on tumor hemodynamics. The non-invasive study of the changes in the tumor microenvironment allowed the elaboration of rational schedules to potentiate the anti-cancer therapy when combining treatments.
Gallez
B
B
Laboratoire de Résonance Magnétique Biomédicale, UCL, Bruxelles.
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D015687:Cell Hypoxia; D004195:Disease Models, Animal; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005544:Forecasting; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000628:therapy*; D010092:Oximetry; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010477:Perfusion; D011048:Polarography
D020533:Angiogenesis Inhibitors; D010100:Oxygen