B-type natriuretic peptide and serum unbound free fatty acid levels after contemporary percutaneous coronary intervention.
OBJECTIVE
To determine the frequency and timing of B-type natriuretic peptide (BNP) and unbound free fatty acid (FFAu) elevation after percutaneous coronary intervention (PCI).


METHODS
Blood samples were collected from 55 patients undergoing PCI within 1 hour prior to PCI, immediately after PCI, 6 hours and 18-24 hours after PCI, and were analyzed for BNP and FFAu.


RESULTS
There was a trend toward a rise in BNP levels at 18-24 hours post-PCI (65 vs. 45 pg/ml; p = 0.056). FFAu levels rose immediately after PCI and returned to baseline by 6 hours postprocedure (2.0 nM pre-PCI, 6.4 nM immediately post-PCI, 1.9 nM 6 hours post-PCI, and 2.2 nM 18-24 hours post-PCI; p < 0.0001). BNP and FFAu levels were elevated post-PCI in 17% and 82% of cases.


CONCLUSIONS
PCI using short inflation times and coronary stenting are associated with a trend toward increased BNP levels at 18-24 hours post-PCI and a transient significant rise in FFAu levels.
Cantor
Warren J
WJ
Southlake Regional Health Centre, 641 Davis Drive, Newmarket, Ontario, Canada. cantorw@rogers.com
Kim
Hahn Hoe
HH
Jolly
Sanjit
S
Moe
Gordon
G
Burstein
Jason M
JM
Mendelsohn
Aurora
A
Kleinfeld
Alan M
AM
Fitchett
David
D
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000628:therapy*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D013318:Stroke Volume; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D020097:Natriuretic Peptide, Brain