title: Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents.
abstract: Chiisanoside is the main component of Acanthopanax sessiliflorus leaves. Simultaneous administration of chiisanoside resulted in a decrease in the plasma TG level and increase of undigested TG in the intestinal lumen after oil gavage to mice. This suggests that chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.
authors.affiliation: Research Institute, Fundamental Research Faculty, Fancl Corporation, Yokohama, Kanagawa 244-0806, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Yoshizumi
authors.forename: Kaeko
authors.initials: K
authors.lastname: Murota
authors.forename: Shiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Hironori
authors.initials: H
authors.lastname: Tomi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsuji
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D009821:Oils / Q000378:metabolism*; D009844:Oligosaccharides / Q000494:pharmacology*; D012450:Safflower Oil / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D019440:Anti-Obesity Agents; D009821:Oils; D009844:Oligosaccharides; D014280:Triglycerides; D014315:Triterpenes; C507583:chiisanoside; D012450:Safflower Oil