The relation between insulin resistance determined by homeostatic [corrected from haemostatic] modelling and slow coronary flow.
BACKGROUND
In this study, we sought to determine whether insulin resistance, which is investigated by homeostatic modelling, is related to slow coronary flow (SCF).


METHODS
A total of 24 patients with SCF (4 females/20 males, mean age 47 +/- 12 years) and 32 patients with normal coronary artery (10 females/22 males, mean age 52 +/- 12 years) were included in the study. Baseline glucose, insulin and plasma lipid levels were measured. A standard oral glucose tolerance test (OGTT) was performed and post-challenge insulin levels were also measured. The index of insulin resistance was calculated with the homeostatic modelling [homeostatic model assessment for insulin resistance index (HOMA-IR)].


RESULTS
There were no differences between the 2 groups with regard to age, lipid levels, blood pressure levels, history of smoking, fasting and post-challenge plasma glucose. Baseline insulin levels were augmented in the SCF group (9.64 +/- 5.93 vs 7.04 +/- 3.26, P = 0.041). HOMA-IR levels were not different between the study groups (2.20 +/- 1.44 vs 1.69 +/- 0.86, P = 0.129). Manifest insulin resistance was significantly higher in the CSF group as compared with the control group (25% vs 3%, P = 0.01).


CONCLUSIONS
Manifest insulin resistance is seen more frequently in patients with SCF.
Nurkalem
Zekeriya
Z
Siyami Ersek Thoracic and Cardiovascular Surgery Center, Cardiology Department Istanbul, Turkey. zeknurkalem@yahoo.com
Orhan
Ahmet L
AL
Alper
Ahmet T
AT
Aksu
Huseyin
H
Ozdamar
Murat
M
Uslu
Nevzat
N
Gorgulu
Sevket
S
Hasdemir
Hakan
H
Sargin
Mehmet
M
Eren
Mehmet
M
D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids