title: [Diabetic ketoacidosis with a fatal issue: is it a MODY3 (maturity-onset diabetes of the young type 3)?].
abstract: Ketoacidotic coma is one of the possible diabetes mellitus first symptoms. It results from complete or relative lack of insuline and is often associated with type 1 diabetes. The authors report a case of a 45-years old woman with inaugural diabetes of which atypical features have motivated the study of MODY gene (maturity-onset diabetes of the young). Gly574ser polymorphism in the HNF-1alpha gene was found, in homozygous state, and the question of the responsibility of this polymorphism in this diabete is asked.
authors.affiliation: Laboratoire de biochimie, Hôpital d'instruction des Armées Robert Picqué, Bordeaux.
authors.forename: C
authors.initials: C
authors.lastname: Dehan
authors.forename: D
authors.initials: D
authors.lastname: Tran Van
authors.forename: H
authors.initials: H
authors.lastname: Delacour
authors.forename: G
authors.initials: G
authors.lastname: Deroudilhe
authors.forename: N
authors.initials: N
authors.lastname: Fritsch
authors.forename: J
authors.initials: J
authors.lastname: Chiappini
authors.forename: E
authors.initials: E
authors.lastname: Dardare
authors.forename: V
authors.initials: V
authors.lastname: Gardet
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics; D003926:Diabetic Coma; D016883:Diabetic Ketoacidosis / Q000175:diagnosis / Q000235:genetics; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D005998:Glycine / Q000235:genetics; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics; D051557:Hepatocyte Nuclear Factor 4 / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011379:Prognosis
chemical_list: C496487:HNF1A protein, human; C496592:HNF4A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D051557:Hepatocyte Nuclear Factor 4; D005998:Glycine