title: Diagnosis and treatment of the infected primary total knee arthroplasty.
abstract: A diagnosis of infection in the painful primary total knee replacement is not always a straightforward endeavor. No single, fail-proof diagnostic study for infection exists. Often multiple diagnostic studies that include imaging, blood work, and joint aspiration as well as history and physical examination need to be considered. Infection may not always be determined before surgery, in which case intraoperative frozen sections can help to confirm infection or refute a negative workup. Treatment options vary, depending on the timing in the infection process and the source of the infection and may consist of simpler treatment courses, such as irrigation, débridement, and polyethylene exchange, to more complex treatment courses, such as two-stage revision with an antibiotic spacer to fusion or amputation. The orthopaedic surgeon uses an essential armamentarium of diagnostic and treatment options to determine the presence of infection and tailor the individual treatment of each patient.
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Mihalko
authors.forename: Abhijit
authors.initials: A
authors.lastname: Manaswi
authors.forename: Quanjun
authors.initials: Q
authors.lastname: Cui
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Schmalzried
authors.forename: Khaled J
authors.initials: KJ
authors.lastname: Saleh
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D003646:Debridement / Q000379:methods*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008828:Microbiological Techniques / Q000379:methods*; D013530:Surgical Wound Infection / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents