title: The hydroxylapatite-bone interface: 10 years after implant installation.
abstract: Reconstruction of a severely atrophied maxilla by sinus augmentation with a mixture of hydroxylapatite (HA) granules and autologous cancellous bone is claimed to be a predictable means to facilitate implant placement. To the authors' knowledge, this is the first human histological case report of plasma-sprayed HA-coated implants being loaded after sinus augmentation was performed with a mixture of HA granules and autologous bone. A patient gave consent for post-mortem analysis of his upper jaw, Ten years after successful reconstruction of his maxilla and functional implant loading, the region of augmentation showed stable contours both radiographically and histologically. In 10 years, the granules had only minimally degraded. HA granules outlined the grafted area to protect it against resorption. The plasma-sprayed HA coating on the dental implant was intact, showing 48% contact with the surrounding bone.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Center, The Netherlands.
authors.forename: H C S
authors.initials: HC
authors.lastname: Beekmans
authors.forename: G J
authors.initials: GJ
authors.lastname: Meijer
authors.forename: R
authors.initials: R
authors.lastname: Barkhuysen
authors.forename: P A
authors.initials: PA
authors.lastname: Blijdorp
authors.forename: M A
authors.initials: MA
authors.lastname: Merkx
authors.forename: J
authors.initials: J
authors.lastname: Jansen
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery; D000539:Alveolar Process / Q000033:anatomy & histology / Q000187:drug effects*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001862:Bone Resorption; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous / Q000379:methods; D020878:Device Removal; D005500:Follow-Up Studies; D006801:Humans; D006882:Hydroxyapatites / Q000494:pharmacology*; D008297:Male; D008437:Maxilla; D008875:Middle Aged; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods; D016348:Osseointegration / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D006882:Hydroxyapatites