Glycemic load, glycemic index, and pancreatic cancer risk in the Netherlands Cohort Study.
BACKGROUND
Recent studies of pancreatic cancer suggest a role for hyperinsulinemia in carcinogenesis. Because insulin is secreted in response to elevated blood glucose concentrations, dietary factors that increase these concentrations may be important in pancreatic carcinogenesis.


OBJECTIVE
The objective was to examine prospectively the relation between pancreatic cancer risk and dietary glycemic load (GL), overall glycemic index (GI), and intake of total carbohydrates and mono- and disaccharides.


METHODS
The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline questionnaire in 1986. After 13.3 y of follow-up, 408 pancreatic cancer cases were detected, 66% of which were microscopically confirmed. A validated 150-item food-frequency questionnaire, completed at baseline, was used to calculate carbohydrate and mono- and disaccharide intakes and the GL and GI of the diet.


RESULTS
Dietary GL, GI, or intake of carbohydrates and mono- and disaccharides were not associated with pancreatic cancer risk in this cohort. Also, the associations were not modified by sex. Our results did not change after the analysis was restricted to microscopically confirmed pancreatic cancer cases or after individuals who reported a history of diabetes at baseline were excluded from the analyses.


CONCLUSIONS
Overall, our findings do not support the hypothesis that GL, GI, or intake of carbohydrates and mono- and disaccharides are positively associated with pancreatic cancer risk. This is in agreement with previous prospective studies that investigated the relation between GL and GI and pancreatic cancer risk.
Heinen
Mirjam M
MM
Department of Epidemiology, Maastricht University, Maastricht, Netherlands. mirjam.heinen@epid.unimaas.nl
Verhage
Bas Aj
BA
Lumey
Lh
L
Brants
Henny Am
HA
Goldbohm
R Alexandra
RA
van den Brandt
Piet A
PA
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D015331:Cohort Studies; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000145:classification / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D038321:Glycemic Index; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin