title: Dihydroxystyrene metabolites from an association of the sponges Poecillastra wondoensis and Jaspis sp.
abstract: Five new dihydroxystyrene metabolites and six known compounds of the same structural class were isolated from an association of the sponges Poecillatra wondoensis and Jaspis sp., collected from Keomun Island, Korea. The structures of novel compounds were determined to be the sodium or N, N-dimethyl guanidinium salts of a dihydroxystyrene dimer (5) and two trimers (6, 7). Two dimers (10, 11) containing imidazole moieties were also identified on the basis of the results of combined spectroscopic analyses. Several compounds exhibited weak to moderate inhibitory effects against isocitrate lyase and sortase A enzymes derived from microorganisms.
authors.affiliation: College of Pharmacy, Seoul National University, Gwanak-Gu, Seoul, Korea.
authors.forename: Yong Ha
authors.initials: YH
authors.lastname: Chang
authors.forename: Daehyun
authors.initials: D
authors.lastname: Shin
authors.forename: Zeyei
authors.initials: Z
authors.lastname: Na
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Dae-Duk
authors.initials: DD
authors.lastname: Kim
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D003546:Cysteine Endopeptidases; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D007723:Korea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D013343:Styrenes; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; D007522:Isocitrate Lyase