title: New aspects in the pathogenesis of abomasal displacement.
abstract: Impaired abomasal motility and an increased accumulation of gas are prerequisites for displacement of the abomasum in the cow. Predisposing factors are the breed (e.g. Holstein-Friesian, Simmental-Red-Holstein cross breeds and Guernsey), genetic background, twin pregnancy, first weeks of lactation, metabolic disorders (ketosis, increased lipomobilisation, insulin resistance), high-concentrate and low-fibre diets, as well as other concomitant diseases, such as endometritis, mastitis and claw disorders. There does not appear to be a strong correlation between increased milk yield or endotoxaemia and abomasal displacement. Recent studies have focused on possible functional disorders of the enteric nervous system within the abomasal wall, since cattle with abomasal displacement have an increased activity of neuronal nitric oxide synthase, as well as decreased acetylcholine sensitivity. In addition, there appear to be significant differences between breeds in the levels of the neurotransmitters substance P (SP) and vasoactive intestinal peptide (VIP) in the abomasal wall. For example, SP (stimulatory) was significantly less in German Holsteins in comparison to the German Fleckvieh, whereas VIP (inhibitory) was markedly increased. These risk factors may explain why Holstein cows are more susceptible to abomasal displacement than other breeds.
authors.affiliation: Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Giessen, Frankfurter Str. 110, 35392 Giessen, Germany. Klaus.Doll@vetmed.unigiessen.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Doll
authors.forename: Marlene
authors.initials: M
authors.lastname: Sickinger
authors.forename: Torsten
authors.initials: T
authors.lastname: Seeger
mesh_terms: D000018:Abomasum / Q000294:innervation / Q000473:pathology*; D000818:Animals; D002417:Cattle / Q000235:genetics; D003612:Dairying; D005260:Female; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000473:pathology / Q000662:veterinary; D010275:Parasympathetic Nervous System / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology / Q000662:veterinary; D013564:Sympathetic Nervous System / Q000473:pathology