Capsaicin inhibits proliferation of endometriotic cells in vitro.
Treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner. In addition, endometriotic cells are more sensitive to capsaicin treatment than immortalized endometrial cells, suggesting that capsaicin may be an admissible drug candidate for treating endometriosis.
Wu
Yan
Y
Taussig Cancer Center, Center for Hematology and Oncology Molecular Therapeutics, Cleveland, Ohio, USA.
Starzinski-Powitz
Anna
A
Guo
Sun-Wei
SW
D002211:Capsaicin / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004715:Endometriosis / Q000473:pathology*; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques
D006131:Growth Inhibitors; D002211:Capsaicin