title: First detection of enterovirus 71 from an acute flaccid paralysis case with residual paralysis in Iran.
abstract: In an attempt to determine the types of non-polio enteroviruses (NPEVs) in acute flaccid paralysis (AFP) cases in Iran, we detected enterovirus 71 (EV71) in an AFP case with residual paralysis for the first time. Cell culture detected no enteroviruses, while RT-PCR and subsequent sequencing revealed that the specimen was positive for EV71. EV71 is the causative agent of a variety of diseases from hand, foot and mouth disease to severe neurological complications and is now considered as an important cause of childhood acute flaccid paralysis.
authors.affiliation: Pathobiology Department, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran. Shahmahmoodi@sina.tums.ac.ir
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahmahmoodi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mehrabi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eshraghian
authors.forename: Talat Mokhtari
authors.initials: TM
authors.lastname: Azad
authors.forename: Hamideh
authors.initials: H
authors.lastname: Tabatabaie
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.forename: Kobra
authors.initials: K
authors.lastname: Farrokhi
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Gouya
authors.forename: Abolreza
authors.initials: A
authors.lastname: Esteghamati
authors.forename: Taha
authors.initials: T
authors.lastname: Moosavi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Zahraie
authors.forename: Katayoon Samimi
authors.initials: KS
authors.lastname: Rad
authors.forename: Zahra
authors.initials: Z
authors.lastname: Shokati
authors.forename: Rakhshandeh
authors.initials: R
authors.lastname: Nategh
mesh_terms: D000293:Adolescent; D029821:Enterovirus A, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000150:complications* / Q000821:virology*; D005260:Female; D006801:Humans; D007492:Iran; D009123:Muscle Hypotonia; D010243:Paralysis; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral