title: Antifouling activity of the sponge metabolite agelasine D and synthesised analogs on Balanus improvisus.
abstract: This study reports a screening study for antifouling (AF) activity of the natural compound agelasine D isolated from marine sponges of the genus Agelas and 20 synthesised analogs of agelasines and agelasimines. Agelasine D, together with two of the analogs, ie AV1003A and AKB695, displayed a strong inhibitory effect on settlement of Balanus improvisus cypris larvae. Agelasine D had an EC50 value of 0.11 microM while the two analogs AV1033A and AKB695 had EC50 values of 0.23 and 0.3 microM, respectively. None of these three compounds affected larval mortality as was the case with several of the analogs tested. Moreover, the effect of AV1033A and AKB695 was reversible. When cyprids after 24 h exposure to the compounds were transferred to fresh seawater, the settlement frequency compared with the controls was completely recovered. The properties of the agelasine D analogs AV1003A and AKB695 make them highly attractive candidates as AF agents in future marine coatings.
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Uppsala, Sweden. martin.sjogren@fkog.uu.se
authors.forename: Martin
authors.initials: M
authors.lastname: Sjögren
authors.forename: Mia
authors.initials: M
authors.lastname: Dahlström
authors.forename: Erik
authors.initials: E
authors.lastname: Hedner
authors.forename: Per R
authors.initials: PR
authors.lastname: Jonsson
authors.forename: Anders
authors.initials: A
authors.lastname: Vik
authors.forename: Lise-Lotte
authors.initials: LL
authors.lastname: Gundersen
authors.forename: Lars
authors.initials: L
authors.lastname: Bohlin
mesh_terms: D000818:Animals; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D011161:Porifera / Q000378:metabolism*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*; D001468:Thoracica / Q000187:drug effects*
chemical_list: D011687:Purines; C509934:agelasine D