Palladium-catalyzed sp(3) CH activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines.
The sp3 C-H activation of a simple alkyl group catalyzed by palladium(0) provides a novel and convenient strategy for the synthesis of various indolines from simple precursors, such as N-alkyl-2-bromoanilines. This study demonstrates that assisting moieties in the substrate such as a pyridine or quaternary carbon are not always necessary for sp3 C-H activation.
Watanabe
Toshiaki
T
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Oishi
Shinya
S
Fujii
Nobutaka
N
Ohno
Hiroaki
H
D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D000814:Aniline Compounds; D007211:Indoles; D010165:Palladium; C057812:indoline