title: Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses.
abstract: Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.
authors.affiliation: MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK. p.j.l.lane@bham.ac.uk
authors.forename: Peter
authors.initials: P
authors.lastname: Lane
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kim
authors.forename: David
authors.initials: D
authors.lastname: Withers
authors.forename: Fabrina
authors.initials: F
authors.lastname: Gaspal
authors.forename: Vasileios
authors.initials: V
authors.lastname: Bekiaris
authors.forename: Guillaume
authors.initials: G
authors.lastname: Desanti
authors.forename: Mahmood
authors.initials: M
authors.lastname: Khan
authors.forename: Fiona
authors.initials: F
authors.lastname: McConnell
authors.forename: Graham
authors.initials: G
authors.lastname: Anderson
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation; D006678:HIV / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007422:Intestines / Q000276:immunology; D017730:Ki-1 Antigen; D008221:Lymphoid Tissue / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000821:virology
chemical_list: D000943:Antigens, Differentiation; D017730:Ki-1 Antigen; C406562:OX40Ig