title: Possible roles of mast cell-derived chymase for skin rejuvenation.
abstract: The relationships between mast cell-derived chymase, angiotensin II, and extracellular matrix production in the skin after intense pulsed light (IPL) were clarified in hamsters. Dorsal areas of the hamsters were irradiated once or twice a week by IPL. The index of extracellular matrix production in the skin was defined as the depth stained with Azan-Mallory stain from the epidermis to the dermis at the point of maximum thickness. The index had significantly increased 7 days after IPL irradiation in sections treated once or twice with IPL compared with that of untreated control sections. The numbers of mast cells, chymase-positive cells, and angiotensin II-positive cells had also significantly increased in IPL-irradiated areas. Significant increases in chymase and angiotensin II activities were observed in the extracts obtained from IPL-irradiated skin. Mast cell-derived chymase may be involved via angiotensin II formation in the dermal extracellular matrix production that occurs after IPL irradiation.
authors.affiliation: Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Amano
authors.forename: Shinji
authors.initials: S
authors.lastname: Takai
authors.forename: Denan
authors.initials: D
authors.lastname: Jin
authors.forename: Koichi
authors.initials: K
authors.lastname: Ueda
authors.forename: Mizuo
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D053818:Chymases / Q000378:metabolism*; D006224:Cricetinae; D005109:Extracellular Matrix / Q000528:radiation effects; D053685:Laser Therapy; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*; D008647:Mesocricetus; D010789:Phototherapy; D012867:Skin / Q000201:enzymology / Q000473:pathology* / Q000528:radiation effects*
chemical_list: D000804:Angiotensin II; D053818:Chymases