title: Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24](6-) polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate.
abstract: The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl)phosphate (BNPP) is promoted by the heptamolybdate anion [Mo7O24](6-) with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.
authors.affiliation: Katholieke Universiteit Leuven, Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Els
authors.initials: E
authors.lastname: Cartuyvels
authors.forename: Gregory
authors.initials: G
authors.lastname: Absillis
authors.forename: Tatjana N
authors.initials: TN
authors.lastname: Parac-Vogt
mesh_terms: D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry*
chemical_list: D008670:Metals; D010755:Organophosphates; D017973:Tungsten Compounds; D008982:Molybdenum; D004247:DNA; D010100:Oxygen