title: Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia.
abstract: Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.
authors.affiliation: Charité School of Medicine, Berlin, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Klempa
authors.forename: Evgeniy A
authors.initials: EA
authors.lastname: Tkachenko
authors.forename: Tamara K
authors.initials: TK
authors.lastname: Dzagurova
authors.forename: Yulia V
authors.initials: YV
authors.lastname: Yunicheva
authors.forename: Vyacheslav G
authors.initials: VG
authors.lastname: Morozov
authors.forename: Natalia M
authors.initials: NM
authors.lastname: Okulova
authors.forename: Galina P
authors.initials: GP
authors.lastname: Slyusareva
authors.forename: Aleksey
authors.initials: A
authors.lastname: Smirnov
authors.forename: Detlev H
authors.initials: DH
authors.lastname: Kruger
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002522:Chlorocebus aethiops; D005260:Female; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012377:Rodentia / Q000821:virology; D012426:Russia / Q000453:epidemiology; D012703:Serotyping; D014709:Vero Cells
chemical_list: D000914:Antibodies, Viral