title: Arterial chemoradiotherapy for locally advanced tongue cancer: analysis of retrospective study of therapeutic results in 88 patients.
abstract: OBJECTIVE
  To retrospectively investigate the therapeutic results of arterial injection therapy by way of the superficial temporal artery for 88 cases of Stage III and IV (M0) tongue cancer and to clarify the factors that affected the therapeutic results.
  
  
  METHODS
  We administered intra-arterial chemoradiotherapy by continuous infusion of carboplatin in 39 patients between January 1993 and July 2002. Systemic concurrent chemotherapy was given to 19 of these patients. We administered intra-arterial chemoradiotherapy with cisplatin with sodium thiosulfate to 49 patients between October 2002 and December 2006. Concurrent systemic chemotherapy was given to 38 of these patients.
  
  
  RESULTS
  The 3-year local control rate was 72% (T2-T3, 80%; and T4, 48%), and the 3-year survival rate was 57% (Stage III, 67%; Stage IV, 43%). On univariate analysis, age, T stage, N stage, overall stage, systemic chemotherapy, difference in intra-arterial chemotherapy, and performance status had a significant effect on survival. On multivariate analysis, N stage, systemic chemotherapy, difference in intra-arterial chemotherapy, and artery selected had a significant effect on survival.
  
  
  CONCLUSIONS
  The therapeutic results of intra-arterial chemoradiotherapy using the superficial temporal artery were not inferior to the results of surgery. In particular, the results of arterial injection therapy using cisplatin with sodium thiosulfate were excellent, and we believe it will be a new therapy for advanced tongue cancer.
authors.affiliation: Department of Radiation Oncology, Aichi Cancer Center Hospital, Chikusaku, Nagoya, Japan. nfuwa@aichi-cc.jp
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fuwa
authors.forename: Takesi
authors.initials: T
authors.lastname: Kodaira
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Furutani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tachibana
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Rie
authors.initials: R
authors.lastname: Nakahara
authors.forename: Takuya
authors.initials: T
authors.lastname: Tomoda
authors.forename: Haruo
authors.initials: H
authors.lastname: Inokuti
authors.forename: Takashi
authors.initials: T
authors.lastname: Daimon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin