title: Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt.
abstract: First synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt is reported.
authors.affiliation: Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. risboodp@mail.nih.gov
authors.forename: Prabhakar A
authors.initials: PA
authors.lastname: Risbood
authors.forename: Charles T
authors.initials: CT
authors.lastname: Kane
authors.forename: Md Tafazzal
authors.initials: MT
authors.lastname: Hossain
authors.forename: Sudhakarrao
authors.initials: S
authors.lastname: Vadapalli
authors.forename: Satish K
authors.initials: SK
authors.lastname: Chadda
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008956:Models, Chemical; D011122:Polyphosphates / Q000138:chemical synthesis / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D012492:Salts / Q000737:chemistry / Q000494:pharmacology*; D014325:Tromethamine / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D011122:Polyphosphates; D000644:Quaternary Ammonium Compounds; D012492:Salts; D014325:Tromethamine; D003841:Deoxycytidine; C005692:triphosphoric acid; D000093542:Gemcitabine