Effect of N-terminal tripeptides of bombesin, litorin, and their analogue on body temperature and vasomotor responses.
Intranasal administration of bombesin caused hypothermia in rats maintained under cold conditions. N-terminal tripeptide of bombesin exhibits intrinsic vasomotor activity, while intranasal administration of its modified analogue produced a more potent hypothermic effect than intranasal bombesin.
Emel'yanova
T G
TG
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow. emel@chph.ras.ru
Sosnovskaya
I V
IV
Guzevatych
L S
LS
Gorjacheva
N N
NN
Voronina
T A
TA
Evstigneeva
E B
EB
Golubovich
V P
VP
D000595:Amino Acid Sequence; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001839:Bombesin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007036:Hypothermia, Induced; D008297:Male; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects*
D009842:Oligopeptides; D010446:Peptide Fragments; C010212:litorin; D001839:Bombesin