title: Outbreak of Chikungunya fever in Mayotte, Comoros archipelago, 2005-2006.
abstract: In 2005-2006, a large outbreak of Chikungunya (CHIK) fever occurred on the western Indian Ocean Islands. In Mayotte, concurrent with an enhanced passive case notification system, we carried out two surveys. A seroprevalence survey designed to document recent CHIK infection was conducted on serum samples collected from pregnant women in October 2005 (n=316) and in March-April 2006 (n=629). A cross-sectional clinical community survey carried out from 2 to 10 May 2006 among 2235 individuals was designed to determine the cumulative incidence of presumptive CHIK fever cases. The seroprevalence of recent infection among pregnant women was 1.6% in October 2005 and rose to 26% in April 2006. The clinical community survey showed that nearly 26% of respondents had experienced presumptive CHIK fever between January and May 2006. Extrapolated to the overall population of Mayotte, these figures lead to an estimated attack rate of 249.5 cases per 1000 population as of early May 2006. Nine patients with the maternofetal form and six subjects with the severe form were recorded. This first emergence of CHIK fever in Mayotte lead to a very large outbreak. Efforts to strengthen surveillance and prevention of arbovirus infection are needed at country and regional levels.
authors.affiliation: Cellule Interrégionale d'Epidémiologie Réunion Mayotte, Direction Régionale des Affaires Sanitaires et Sociales,Brassens, BP 50, 97408 Saint-Denis Cedex 9, La Réunion, France. daouda.sissoko@sante.gouv.fr
authors.forename: Daouda
authors.initials: D
authors.lastname: Sissoko
authors.forename: Denis
authors.initials: D
authors.lastname: Malvy
authors.forename: Claude
authors.initials: C
authors.lastname: Giry
authors.forename: Gilles
authors.initials: G
authors.lastname: Delmas
authors.forename: Christophe
authors.initials: C
authors.lastname: Paquet
authors.forename: Philippe
authors.initials: P
authors.lastname: Gabrie
authors.forename: François
authors.initials: F
authors.lastname: Pettinelli
authors.forename: Marie Anne
authors.initials: MA
authors.lastname: Sanquer
authors.forename: Vincent
authors.initials: V
authors.lastname: Pierre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018354:Alphavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D000818:Animals; D002646:Chikungunya virus / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D021821:Communicable Diseases, Emerging / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D003430:Cross-Sectional Studies; D009033:Culicidae; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000302:isolation & purification; D007195:Indian Ocean Islands / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D016036:Seroepidemiologic Studies
chemical_list: D007075:Immunoglobulin M