Imaging in the era of molecular oncology.
New technologies for imaging molecules, particularly optical technologies, are increasingly being used to understand the complexity, diversity and in vivo behaviour of cancers. 'Omic' approaches are providing comprehensive 'snapshots' of biological indicators, or biomarkers, of cancer, but imaging can take this information a step further, showing the activity of these markers in vivo and how their location changes over time. Advances in experimental and clinical imaging are likely to improve how cancer is understood at a systems level and, ultimately, should enable doctors not only to locate tumours but also to assess the activity of the biological processes within these tumours and to provide 'on the spot' treatment.
Weissleder
Ralph
R
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.
Pittet
Mikael J
MJ
D003952:Diagnostic Imaging / Q000379:methods / Q000639:trends*; D005453:Fluorescence; D017930:Genes, Reporter; D006801:Humans; D008853:Microscopy; D025202:Molecular Diagnostic Techniques / Q000379:methods / Q000639:trends*; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology