title: Quality-of-life and asthma-severity in general population asthmatics: results of the ECRHS II study.
abstract: BACKGROUND
  Health-related quality-of-life (HRQL) has been poorly studied in large samples of asthmatics from the general population. HRQL and its relationship to asthma-severity were assessed among 900 asthmatics enrolled in the European Community Respiratory Health Survey.
  
  
  METHODS
  Among asthmatics, 864 completed the short form-36 (SF-36) questionnaire and 477 also completed the Asthma Quality-of-life Questionnaire (AQLQ). A 4-class asthma-severity scale, combining clinical items, forced expiratory volume in 1 s and the level of treatment and the different asthma-severity components (each of the clinical items and hospitalization) were studied in relation to HRQL.
  
  
  RESULTS
  Mean SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores (45.5 and 48.8 respectively) were lower than expected in a general population. The mean total AQLQ score was 5.8. The AQLQ score and to a lesser extent the PCS score were significantly related to the 4-class asthma-severity scale, although the risk of having a lower HRQL score did not vary proportionally across the levels of severity. Asthma-severity had no impact on the MCS score. Asthma attack frequency and hospitalization were associated with both total AQLQ and PCS scores, whereas nocturnal symptoms and lung function were more strongly related to the AQLQ and PCS score respectively.
  
  
  CONCLUSIONS
  In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL.
authors.affiliation: INSERM, U823, Grenoble, France.
authors.forename: V
authors.initials: V
authors.lastname: Siroux
authors.forename: A
authors.initials: A
authors.lastname: Boudier
authors.forename: J M
authors.initials: JM
authors.lastname: Anto
authors.forename: L
authors.initials: L
authors.lastname: Cazzoletti
authors.forename: S
authors.initials: S
authors.lastname: Accordini
authors.forename: J
authors.initials: J
authors.lastname: Alonso
authors.forename: I
authors.initials: I
authors.lastname: Cerveri
authors.forename: A
authors.initials: A
authors.lastname: Corsico
authors.forename: A
authors.initials: A
authors.lastname: Gulsvik
authors.forename: D
authors.initials: D
authors.lastname: Jarvis
authors.forename: R
authors.initials: R
authors.lastname: de Marco
authors.forename: A
authors.initials: A
authors.lastname: Marcon
authors.forename: E A
authors.initials: EA
authors.lastname: Marques
authors.forename: M
authors.initials: M
authors.lastname: Bugiani
authors.forename: C
authors.initials: C
authors.lastname: Janson
authors.forename: B
authors.initials: B
authors.lastname: Leynaert
authors.forename: I
authors.initials: I
authors.lastname: Pin
mesh_terms: D000328:Adult; D001249:Asthma / Q000503:physiopathology / Q000523:psychology; D005060:Europe; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires