Estimating relative risks from significant family-based association studies.
Two approaches are described to estimate relative risks from significant family-based association studies. They can be used to obtain either point estimates or confidence regions. The approaches are evaluated by a simulation study and illustrated by application to a real data set. It is shown that both approaches largely reduce the bias in the relative risk estimates which can occur in case that the significant outcome of the study from which the relative risks are estimated is ignored.
Knapp
Michael
M
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany. knapp@uni-bonn.de
D002648:Child; D002971:Cleft Lip / Q000235:genetics; D002972:Cleft Palate / Q000235:genetics; D003198:Computer Simulation; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005821:Genetic Techniques; D005838:Genotype; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D009679:Nuclear Family; D010290:Parents; D018570:Risk Assessment
C109803:IRF6 protein, human; D050835:Interferon Regulatory Factors