Complex I: a complex gateway to the powerhouse.
Complex I, the main entry point for electrons to the respiratory chain, is of critical importance for cellular energy homeostasis. In this issue of Cell Metabolism, Kruse and coworkers (2008) describe the first mouse knockout for a complex I structural subunit, thus advancing our understanding of complex I in disease.
Sterky
Fredrik Hansson
FH
Department of Laboratory Medicine, Karolinska Institutet, S-141 86 Stockholm, Sweden.
Larsson
Nils-Göran
NG
D000818:Animals; D042967:Electron Transport Complex I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D028361:Mitochondrial Diseases / Q000378:metabolism*; D009154:Mutation; D009245:NADH Dehydrogenase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
D009245:NADH Dehydrogenase; D042967:Electron Transport Complex I