The multifaceted small RNAs.
Small RNA molecules are now being recognized as master regulators of gene activity. Although known initially for their gene-silencing functions, recent discoveries have revealed that small RNAs can also activate gene expression. These two opposing activities of gene silencing and activation together constitute an integrated gene regulatory mechanism.
Li
Long-Cheng
LC
Department of Urology, University of California San Francisco, San Francisco, California 94143, USA. lilc@urology.ucsf.edu
D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008957:Models, Genetic; D012330:RNA, Double-Stranded / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism*; D015533:Transcriptional Activation / Q000235:genetics
D035683:MicroRNAs; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering