[Mercury toxicity: trace element interactions and detoxification activity by L-arginine].
Mercury (Hg) exposure makes happen disease to humans and animals spreading in all body compartments, especially in liver and kidney. In these ones, copper, zinc, manganese and iron were investigated to assess perturbation of essential metals' homeostasis due to Hg chronic intoxication. Because L-arginine, is able to induce beneficial influence on immunologic functions on mice intoxicated with Hg, we also studied the efficiency of detoxification process before and after treatment with this aminoacid. Adding L-arginine to diet of the intoxicated mice we achieved a good restoration to normal homeostatic conditions.
Santarelli
L
L
Medicina del Lavoro- Dipartimento di Patologia Molecolare e Terapie Innovative, Facoltà di Medicina e Chirurgia, Università Politecnica delle Marche, Via Tronto 10/A, Torrette Ancona. l.santarelli@univpm.it
Piacenza
F
F
Bonacucina
V
V
Malavolta
M
M
Mocchegiani
E
E
Bracci
M
M
D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D008658:Inactivation, Metabolic; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008628:Mercury / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C
D001120:Arginine; D008628:Mercury