title: Diagnostic test evaluation of a nasal flow monitor for obstructive sleep apnea detection in sleep apnea research.
abstract: In this diagnostic test evaluation of a nasal flow monitoring device for obstructive sleep apnea (OSA), 34 patients referred for polysomnography were studied at home for three consecutive nights with the monitor. The mean age of subjects (+/-SD) was 41.9+/-10.3 years, and their mean apnea-hypopnea index (AHI) was 31.5+/-27.2. The difference between the average AHI from three nights at home on the monitor and the polysomnogram (PSG) result was 1.8+/-17.1. The area under the receiver operating characteristic curve (AUC) for PSG AHI > or = 10 was .96. With a threshold AHI of 18 on the flow monitor, sensitivity was .92, specificity .86, positive predictive value .96, and negative predictive value .75. For detecting severe OSA (AHI > or = 30), the AUC was .85. With knowledge of appropriate thresholds and the pretest risk of OSA, the flow monitor can be used to detect or exclude OSA for sleep-related research, as well as to identify severe cases needing priority for further evaluation.
authors.affiliation: University of Sydney, Sydney, New South Wales, Australia. keithw@woolcock.org.au
authors.forename: Keith K H
authors.initials: KK
authors.lastname: Wong
authors.forename: David
authors.initials: D
authors.lastname: Jankelson
authors.forename: Adrian
authors.initials: A
authors.lastname: Reid
authors.forename: Gunnar
authors.initials: G
authors.lastname: Unger
authors.forename: George
authors.initials: G
authors.lastname: Dungan
authors.forename: Jan A
authors.initials: JA
authors.lastname: Hedner
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Grunstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000502:physiology*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D009296:Nasal Cavity / Q000502:physiology*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000503:physiopathology*