title: Organocatalytic asymmetric transfer hydrogenation in aqueous media using resin-supported peptide having a polyleucine tether.
abstract: A resin-supported N-terminal prolyl peptide having a beta-turn motif and hydrophobic polyleucine chain effectively catalyzed the asymmetric transfer hydrogenation under aqueous conditions. The polyleucine tether provides a hydrophobic cavity in aqueous media that brought about a remarkable acceleration of the reaction. In addition, the polyleucine chain also turned out to be essential for high enantioselectivity.
authors.affiliation: Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Akagawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Akabane
authors.forename: Seiji
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D010455:Peptides; D012117:Resins, Synthetic; D014867:Water; C027819:polyleucine