Validity of the Pediatric Quality Of Life Inventory for youth with sickle cell disease.
OBJECTIVE
Evaluate the validity of the Pediatric Quality of Life Inventory (PedsQL) for sickle cell disease (SCD).


METHODS
Sixty-eight parent-child dyads (children 5-18 years) completed the PedsQL. Medical record review assessed history of specific morbidities.


RESULTS
Internal consistency of the scales varied. The strongest reliability was for parent proxy-report for specific domains or for global functioning scores with either informant. Modest internal consistency was found for specific domains with child informants, particularly for younger children. Moderate convergent validity was found between informants. History of neurologic problems or major pain episodes indicated criterion validity for specific scales.


CONCLUSIONS
The PedsQL appears to validly assess quality of life in youth with SCD. Domain-specific measurement of quality of life was limited by (a) low reliability for youth-report and (b) lack of discriminant validity. Choice of informant may be important when evaluating quality of life effects from pain or neurologic problems in SCD.
McClellan
Catherine B
CB
Department of Psychology, University of South Carolina, Columbia, SC 29208, USA. mcclellb@gwm.sc.edu
Schatz
Jeffrey
J
Sanchez
Carmen
C
Roberts
Carla W
CW
D000223:Adaptation, Psychological; D000293:Adolescent; D001741:Black or African American / Q000523:psychology; D000755:Anemia, Sickle Cell / Q000208:ethnology / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000523:psychology; D010552:Personality Assessment / Q000706:statistics & numerical data; D010555:Personality Inventory / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D012803:Sick Role