title: An analysis of correspondence between unique rabies virus variants and divergent big brown bat (Eptesicus fuscus) mitochondrial DNA lineages.
abstract: The literature supports that unique rabies virus (RABV) variants are often compartmentalized in different species of bats. In Colorado, two divergent mtDNA lineages of big brown bats (Eptesicus fuscus) co-occur. RABV associated with this species also segregates into two clades. We hypothesized that unique RABV variants might be associated with mtDNA lineages of Colorado big brown bats. DNA was extracted from brain tissue of rabid big brown bats, the ND2 gene was amplified to determine mtDNA lineage, and the lineage was compared to a previously derived phylogenetic analysis of the RABV N gene. No correspondence was found between host bat lineage and RABV variant.
authors.affiliation: National Wildlife Research Center, 4101 LaPorte Avenue, Fort Collins, CO 80521, USA. Melissa.Neubaum@aphis.usda.gov
authors.forename: M A
authors.initials: MA
authors.lastname: Neubaum
authors.forename: V
authors.initials: V
authors.lastname: Shankar
authors.forename: M R
authors.initials: MR
authors.lastname: Douglas
authors.forename: M E
authors.initials: ME
authors.lastname: Douglas
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Shea
authors.forename: C E
authors.initials: CE
authors.lastname: Rupprecht
mesh_terms: D000828:Animal Population Groups / Q000235:genetics* / Q000821:virology*; D000818:Animals; D002685:Chiroptera / Q000235:genetics* / Q000821:virology*; D003120:Colorado / Q000453:epidemiology; D004272:DNA, Mitochondrial / Q000235:genetics*; D014644:Genetic Variation; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000235:genetics; D019590:Nucleocapsid Proteins / Q000235:genetics; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial; D019590:Nucleocapsid Proteins; D009245:NADH Dehydrogenase