title: "Bubble-like" lung metastases in osteosarcoma patients.
abstract: OBJECTIVE
  Cavitation of pulmonary metastases have been reported by several authors either as a spontaneous phenomenon or as a consequence of chemotherapy. We present two cases, with this type of image in follow-up, and 20-45 months after the end of treatment. This was the first sign of pulmonary metastases.
  
  
  RESULTS
  Two patients with osteogenic sarcoma developed radiological evidence of pulmonary "bubble-like" cavitation several years following completion of chemotherapy. In one patient the "bubble-like" cavitation transformed into a solid nodule. Both patients had surgical resections of all pulmonary lesions, and histology confirmed presence of viable osteosarcoma metastases.
  
  
  CONCLUSIONS
  The two cases suggest that onset of "bubble-like" cavitation in lung parenchyma of osteosarcoma patients may be the first sign of pulmonary metastases.
authors.affiliation: General Surgery, The Rizzoli Orthopaedic Institute, Bologna 40136, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Briccoli
authors.forename: Michele
authors.initials: M
authors.lastname: Rocca
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Salone
authors.forename: Maria
authors.initials: M
authors.lastname: Di Fiore
authors.forename: Daniel
authors.initials: D
authors.lastname: Vanel
authors.forename: Alba
authors.initials: A
authors.lastname: Balladelli
authors.forename: Marco
authors.initials: M
authors.lastname: Alberghini
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D014057:Tomography, X-Ray Computed / Q000379:methods*