Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys.
The developmental pathophysiology of polycystic ovary syndrome (PCOS) is unknown. However, prenatally androgenized female rhesus monkeys exhibit ovarian and endocrinological features that mimic those found in women with PCOS. Thus, prenatal androgen excess may provide an etiology for hyperandrogenism and anovulation in adulthood.
Abbott
D H
DH
Wisconsin Regional Primate Research Center, Departments of Obstetrics and Gynecology and the Endocrinology-Reproductive Physiology Training Program, University of Wisconsin, Madison, WI 53715, USA.
Dumesic
D A
DA
Eisner
J R
JR
Colman
R J
RJ
Kemnitz
J W
JW