Proinsulin trafckin and processing in the pancreatic B cell.
Insulin is synthesized as a precursor, preproinsulin, in the rough endoplasmic reticulum of the pancreatic B cell. The combination of precursor processing and the movement of products in vesicles from one subcellular compartment to the next results in insulin becoming stored in secretory granules ready for release in response to a secretagogue.
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Laboratoires de Recherche Louis Jeantet, Centre Médical Universitaire, University of Geneva Medical School, 1, rue Michel-Servet, CH-1211 Geneva 4, Switzerland.