[Effective treatment with oral administration of UFT and leucovorin (Uzel) in a patient with liver metastasis and peritoneal dissemination from cecal cancer].
A 70-year-old woman had been diagnosed with advanced cecal cancer with liver metastasis. She had initially undergone a right hemicolectomy for cecal cancer. Although secondary surgery for liver metastasis was performed 2 months after initial surgery, the intra-operative findings showed peritoneal dissemination of diaphragm and ligament teres and liver metastasis, making curative resection impossible. Therefore , combination oral administration of UFT and LV (Uzel) was started (UFT 300 mg/day, LV 75 mg/day, 4 weeks of therapy followed by a 1-week treatment break). Two months after 4 courses, the liver metastasis had markedly diminished and CEA was within the normal range. A good complete response of the liver metastasis was achieved. In conclusion, this treatment was convenient and effective.
Mimatsu
Kenji
K
Department of Surgery, Social Insurance Yokohama Central Hospital.
Kawasaki
Atsushi
A
Aramaki
Osamu
O
Kuboi
Youichi
Y
Amano
Sadao
S
Oida
Takatsugu
T
D000284:Administration, Oral; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002430:Cecal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000008:administration & dosage / Q000627:therapeutic use
D005641:Tegafur; D014498:Uracil; D002955:Leucovorin