title: [The role of melatonin in regulation of gonadal function and its use in the treatment of pathological climax symptoms].
abstract: Pathological current of climacterium leads to significant decrease in quality of life of women. Hormone therapy has a number of contra-indications. With the purpose of optimization of treatment of patients with a climacteric syndrome search of new and more perfect approaches to therapy of climacteric frustration is necessary. Melatonin production in a human body decreases with the years and its production in old age makes only half from its level. Age decrease of melatonin synthesis leads to progressive decrease of woman fertility. In this connection the research of a level of melatonin in women with a climacteric syndrome depending on current of disease was carried out. The opportunity to use the Melaxen in treatment of symptoms of pathological climacterium both in the form of monotherapy, and in combination with replacement hormone therapy was estimated. The greatest efficiency of application of Melaxen in combination with hormone replacement therapy has been established.
authors.forename: L I
authors.initials: LI
authors.lastname: Mal'tseva
authors.forename: E A
authors.initials: EA
authors.lastname: Gafarova
authors.forename: G Kh
authors.initials: GKh
authors.lastname: Garipova
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood / Q000652:urine; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008550:Melatonin / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D008593:Menopause / Q000097:blood / Q000187:drug effects / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged
chemical_list: D002395:Catecholamines; D006728:Hormones; D008055:Lipids; D008550:Melatonin