title: Boolean logic gates that use enzymes as input signals.
abstract: Biochemical systems that demonstrate the Boolean logic operations AND, OR, XOR, and InhibA were developed by using soluble compounds, which represent the chemical "devices", and the enzymes glucose oxidase (GOx), glucose dehydrogenase (GDH), alcohol dehydrogenase (AlcDH), and microperoxidase-11 (MP-11), which operated as the input signals that activated the logic gates. The enzymes were used as soluble materials and as immobilized biocatalysts. The studied systems are proposed to be a step towards the construction of "smart" signal-responsive materials with built-in Boolean logic.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA.
authors.forename: Guinevere
authors.initials: G
authors.lastname: Strack
authors.forename: Marcos
authors.initials: M
authors.lastname: Pita
authors.forename: Maryna
authors.initials: M
authors.lastname: Ornatska
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D001234:Aspergillus niger / Q000201:enzymology; D002384:Catalysis; D042843:Glucose 1-Dehydrogenase / Q000378:metabolism*; D005949:Glucose Oxidase / Q000378:metabolism*; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D011549:Pseudomonas / Q000201:enzymology; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D012995:Solubility
chemical_list: D000426:Alcohol Dehydrogenase; D042843:Glucose 1-Dehydrogenase; D005949:Glucose Oxidase