An improved synthesis of arsenic-biotin conjugates.
An amide linked conjugate of p-aminophenylarsine oxide and biotin is conveniently prepared in a one-pot procedure by the reaction of biotinyl chloride, formed in situ, with p-aminophenyldichloroarsine. The reaction of the arsine oxide-biotin conjugate with 1,2-ethanedithiol produces the stabilized dithiarsolane. These reagents are now readily available for a variety of applications.
Heredia-Moya
Jorge
J
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA.
Kirk
Kenneth L
KL
D001152:Arsenicals / Q000138:chemical synthesis* / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D008623:Mercaptoethanol / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D001152:Arsenicals; C530735:N-(4-(1,3,2)dithiarsolan-2-yl-phenyl)hexahydro-2-oxo-(3aS,4S,6aR)-1H-trieno(3,4-d)imidazole-4-pentamide; C530734:p-aminophenylarsine oxide; C053801:4-aminophenyldichloroarsine; D008623:Mercaptoethanol; D001710:Biotin; C031854:1,2-ethanedithiol