title: Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation.
abstract: A modified alkalizing supplementation (MAS) was tested on skeletal muscle metabolism in aged rats undergoing exhaustive exercise. Aged Wistar rats were allocated into two groups: saline (A) and saline added with 16 mg of MAS (B) before treadmill exercise. Blood and gastrocnemius and soleus muscle were analyzed after exercise for succinate dehydrogenase (SDH), acetylcarnitine (ALCAR), and glycogen. Lactic acid (LA), creatin-phosphokinase (CPK), and gas analysis were tested in the blood. Exercise caused a significant increase of LA and CPK and muscle glycogen fall. Arterial desaturation at exhaustion was prevented in the B group (p < 0.05). Exercise-induced increase of SDH and ALCAR was further enhanced in B rats (p < 0.05). This study suggests that MAS can improve fast and endurance muscle metabolism in aged rats by increasing cellular acetyl group availability and tricarboxylic acid turnover.
authors.affiliation: GAIA Age-Management Foundation, Pavia, Italy. fmarchimede@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: De Hua
authors.initials: de H
authors.lastname: Chui
authors.forename: Aldo
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: Flavia
authors.initials: F
authors.lastname: Fayet
authors.forename: Tsin
authors.initials: T
authors.lastname: Liu
authors.forename: Paolo
authors.initials: P
authors.lastname: Marandola
mesh_terms: D000108:Acetylcarnitine / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001784:Blood Gas Analysis; D003402:Creatine Kinase / Q000378:metabolism; D019587:Dietary Supplements; D006003:Glycogen / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D019344:Lactic Acid; D000108:Acetylcarnitine; D006003:Glycogen; D013385:Succinate Dehydrogenase; D003402:Creatine Kinase