title: Ecthyma gangrenosum following toxic epidermal necrolysis syndrome in a 3-year-old boy-a survivable series of events.
abstract: Toxic epidermal necrolysis syndrome (TENS) is a severe but rare skin reaction leading to epidermal desquamation of greater than 30% of the TBSA. It is most commonly precipitated by the administration of medication. Frequent complications of this syndrome include local wound infections, respiratory, mucocutaneous, and ocular complications. Ecthyma gangrenosum (EG) is a rare disease characterized by a milliary seeding of the cutaneous tissue with Gram-negative bacteria; it is most commonly seen in immunocompromised individuals. Here we report a 3-year-old boy who developed EG subsequent to TENS. Although he had a complicated and prolonged hospital course, he survived these series of events. To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses.
authors.affiliation: Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Gresik
authors.forename: Luke P
authors.initials: LP
authors.lastname: Brewster
authors.forename: Gerard
authors.initials: G
authors.lastname: Abood
authors.forename: Kathy G
authors.initials: KG
authors.lastname: Supple
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Silver
authors.forename: Richard L
authors.initials: RL
authors.lastname: Gamelli
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Nickoloff
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002675:Child, Preschool; D004473:Ecthyma / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005734:Gangrene / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D008297:Male; D012307:Risk Factors; D016038:Skin Transplantation; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000382:microbiology / Q000601:surgery; D014031:Tobramycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem; D014031:Tobramycin