[Estimation of postmortem interval with multivoxel-voxel proton 1H-MR spectroscopy].
OBJECTIVE
The purpose of our study was to evaluate the postmortem interval with multi-voxel 1H-MR spectroscopy.


METHODS
Twelve healthy rabbits were studied and the quantities of N-acetylaspartate, total choline, phosphocreatine and creatine were measured by 1H-MR spectroscopy after death at 0.5, 1, 2, 4, 6, 8, 12, 16, and 24 h.


RESULTS
The levels of Naa/Cr and Naa/Ch decreased following death, while the level of Ch/Cr increased initially and then decreased following death.


CONCLUSIONS
Multi-voxel proton MR spectroscopy for Naa/Cr and Ch/Cr metabolic ratio could be used in future postmortem interval studies.
Yang
Tian-Tong
TT
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yttwowo@163.com
Li
Zhen-Wei
ZW
Liu
Liang
L
Zheng
Na
N
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002794:Choline / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism; D004195:Disease Models, Animal; D004618:Embolism, Air; D005260:Female; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D011180:Postmortem Changes; D011522:Protons; D011817:Rabbits; D012044:Regression Analysis; D013997:Time Factors
D015415:Biomarkers; D011522:Protons; D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline