Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein.
OBJECTIVE
To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP).


METHODS
One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared.


RESULTS
The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower.


CONCLUSIONS
ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.
Zhou
Yan-Ming
YM
Department of Hepato-Biliary-Pancreato-Vascular Surgery, The First Xiamen Hospital, Fujian Medical University, Xiamen, China.
Yang
Jia-Mei
JM
Li
Bin
B
Yin
Zheng-Feng
ZF
Xu
Feng
F
Wang
Bin
B
Liu
Peng
P
Li
Zhi-Min
ZM
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000821:virology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology* / Q000821:virology; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000821:virology; D005260:Female; D006515:Hepatitis B virus / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000166:cytology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013234:Stem Cells / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins