title: [A case of lumbar metastases from rectal cancer successfully treated by UFT plus oral leucovorin (LV) therapy].
abstract: A 63-year-old man had undergone a low anterior resection for rectal cancer with multiple liver metastases. Oral UFT (450 mg/day) administration alone was started after the operation. After 6 months post operatively, the patient was diagnosed as anastomosis recurrence because of ileus by abdominal X-ray. Transverse loop colostomy was performed by emergency surgery. After surgery, he suffered from paraplegia for lumbar vertebrae metastases. UFT+LV therapy was started. After chemotherapy a significant reduction of the lymph node and liver metastases and an apparent decrease in CEA and CA19-9 were observed. The patient left the hospital and showed no signs of tumor exacerbation for three months. The patient died of aggravation of primary disease afterwards. The therapy was safe and effective, and has successfully maintained the quality of life (QOL) of this patient.
authors.affiliation: Department of Surgery, Division of Gastrointestinal Surgery, Aichi Medical University School of Medicine.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Suzumura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagata
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Kotake
authors.forename: Takashi
authors.initials: T
authors.lastname: Arikawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ando
authors.forename: Noiku
authors.initials: N
authors.lastname: Nakao
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Jun
authors.initials: J
authors.lastname: An
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nonami
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D014498:Uracil / Q000627:therapeutic use
chemical_list: D014408:Biomarkers, Tumor; D005641:Tegafur; D014498:Uracil; D002955:Leucovorin