title: Pregnancy in a hermaphrodite with a male-predominant mosaic karyotype.
abstract: OBJECTIVE
  To report a pregnancy in a hermaphrodite and review of the literature.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  Clinical.
  
  
  METHODS
  A patient with male-predominant mosaic karyotype 96% 46XY.
  
  
  METHODS
  Removal of left ovotestis in combination with a supracervical hysterectomy and bilateral salpingo-oophorectomy.
  
  
  METHODS
  Identification of published cases of pregnancy and hermaphroditism.
  
  
  RESULTS
  The current patient had previous pregnancy and a wedge biopsy of her left gonad, which demonstrated an ovotestis and an area suspicious for a gonadoblastoma. After delivery of her second pregnancy, the patient underwent a hysterectomy and bilateral salpingo-oophorectomy. The histopathologic evaluation following bilateral oophorectomy demonstrated a residual ovotestis without further evidence of a gonadoblastoma. Review of the literature identified 10 other cases of pregnancy in a hermaphrodite patient.
  
  
  CONCLUSIONS
  This is the 11th reported case of fertility in a true hermaphrodite and only the second report of a mosaic true hermaphrodite to demonstrate fertility. This is the only case of a pregnancy involving a male-predominant mosaic 96% 46XY and the only case to confirm the genetics of the offspring.
authors.affiliation: Kaiser Permanente Southern California, West Los Angeles and Los Angeles Medical Centers, Los Angeles, California 90034, USA.
authors.forename: Samantha A
authors.initials: SA
authors.lastname: Schoenhaus
authors.forename: Scott E
authors.initials: SE
authors.lastname: Lentz
authors.forename: Peter
authors.initials: P
authors.lastname: Saber
authors.forename: Malcom G
authors.initials: MG
authors.lastname: Munro
authors.forename: Seth
authors.initials: S
authors.lastname: Kivnick
mesh_terms: D000328:Adult; D005260:Female; D005298:Fertility; D006060:Gonadal Dysgenesis, Mixed / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D018238:Gonadoblastoma / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy; D007621:Karyotyping; D010535:Laparoscopy; D050498:Live Birth; D008297:Male; D009030:Mosaicism; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D010052:Ovariectomy; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D050090:Ovotesticular Disorders of Sex Development / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D013736:Testicular Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D013737:Testis / Q000473:pathology* / Q000601:surgery