title: Human and porcine neurocysticercosis: differences in the distribution and developmental stages of cysticerci.
abstract: OBJECTIVE
  To describe and compare the clinical impacts of neurocysticercosis (NC) caused by Taenia solium in humans and pigs.
  
  
  METHODS
  Comparative study of the brains of 16 asymptomatic pigs and 35 human NC cases (15 asymptomatic and 20 symptomatic).
  
  
  RESULTS
  In humans, cysticerci were more frequently located in the ventricles and subarachnoid space at the base of the brain (11.8%vs. 1.6%; P = 0.001 and 25.9%vs. 0%; P < 0.0001, respectively) while in pigs, cysticerci were more frequently found in the parenchyma (44.4%vs. 7.6%; P < 0.0001). In human brains, 75.9% of the cysticerci were calcified, while in pigs all cysticerci were in the vesicular stage.
  
  
  CONCLUSIONS
  The duration of infection and the host-parasite relationship (such as immune reactivity and brain haemodynamics) differ between humans and pigs. This may account for the different distribution and stage of the cysticerci among humans and pigs.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico DF, Mexico.
authors.forename: B
authors.initials: B
authors.lastname: Sáenz
authors.forename: J
authors.initials: J
authors.lastname: Ramírez
authors.forename: A
authors.initials: A
authors.lastname: Aluja
authors.forename: A
authors.initials: A
authors.lastname: Escobar
authors.forename: G
authors.initials: G
authors.lastname: Fragoso
authors.forename: J
authors.initials: J
authors.lastname: Morales
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Tamayo
authors.forename: F
authors.initials: F
authors.lastname: Rosetti
authors.forename: C
authors.initials: C
authors.lastname: Larralde
authors.forename: E
authors.initials: E
authors.lastname: Sciutto
authors.forename: A
authors.initials: A
authors.lastname: Fleury
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology; D001927:Brain Diseases / Q000469:parasitology* / Q000662:veterinary; D003552:Cysticercus / Q000254:growth & development / Q000302:isolation & purification; D006801:Humans; D008279:Magnetic Resonance Imaging; D020019:Neurocysticercosis / Q000469:parasitology* / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*; D041201:Taenia solium / Q000254:growth & development* / Q000302:isolation & purification