Biologic characteristics of mesenchymal stromal cells and their clinical applications in pediatric patients.
In the past few years, intensive research in the understanding of the biologic characteristics of the mesenchymal stromal cells has already led to some early clinical applications. The aim of this review is to summarize the latest information from basic science advances and the outcome of their use in clinical practice with a particular focus in pediatric patients. The minimum criteria required to identify mesenchymal stromal cells, their immunosuppressive-nonimmunogenic properties and their attribution in the treatment of graft-versus-host disease, in the acceleration of hematopoietic recovery, in tissue repair/tissue engineering and in the treatment of selected inherited disorders are discussed. Appropriate preclinical models, completion of ongoing and development of new clinical trials will establish the role of these cells in the treatment of both adult and pediatric patients.
Pelagiadis
Iordanis
I
Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece.
Dimitriou
Helen
H
Kalmanti
Maria
M
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002454:Cell Differentiation; D002648:Child; D006086:Graft vs Host Disease / Q000601:surgery; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D017674:Hypophosphatemia / Q000601:surgery; D007223:Infant; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000276:immunology / Q000502:physiology*; D008661:Metabolism, Inborn Errors / Q000601:surgery; D010013:Osteogenesis Imperfecta / Q000601:surgery; D015626:Tissue Expansion / Q000379:methods
D015703:Antigens, CD; D015395:Histocompatibility Antigens Class I