title: Isolation and structure determination of the cembranoid eunicin from a new genus of octocoral, Pseudoplexaura.
abstract: The known cembranoid diterpene eunicin (1) was isolated from a new genus of octocoral, Pseudoplexaura, collected in the Caribbean. The complete assignment of the 13C and 1H NMR spectra, including differentiation of pro-R and pro-S hydrogens and elucidation of all J values, was accomplished with the aid of TOCSY, HSQC, and HMBC data, and a consideration of three low-energy conformations using SYBYL.
authors.affiliation: Department of Science, Cushing Academy, Ashburnham, MA 01430, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Sponholtz
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Bianco
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Gribble
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D005779:Immunodiffusion; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009904:Optical Rotation; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; C082582:eunicin