The solvent-free synthesis of 1,4-dihydropyridines under ultrasound irradiation without catalyst.
The condensation of aldehydes, ethyl acetoacetate and ammonium acetate result 1,4-dihydropyridines in 82-99% yields under ultrasound irradiation without solvent and catalyst at room temperature. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields.
Wang
Shu-Xiang
SX
Laboratory of Chemical Biology, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China. wsx@mail.hbu.edu.cn
Li
Zhi-Yan
ZY
Zhang
Jin-Chao
JC
Li
Ji-Tai
JT
D002384:Catalysis; D002853:Chromatography, Liquid; D004095:Dihydropyridines / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014465:Ultrasonics
D004095:Dihydropyridines; C038806:1,4-dihydropyridine