Structure-antibacterial activity relationship for 9-O,9'-O-demethyl (+)-virgatusin.
The relationship between the antibacterial activity and structure of 9-O,9'-O-demethyl (+)-virgatusin (Virg 3) was examined. The conversion of hydroxy groups on the 9 and 9' positions to amino groups increased the activity. It was found that the 3'-methoxy group was more important for higher activity than the 4'-methoxy group on the 7'-phenyl group, and that the 3,4-methylenedioxy group on the 7-phenyl group was necessary for activity.
Tago
Ryosuke
R
Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.
Yamauchi
Satoshi
S
Maruyama
Masafumi
M
Akiyama
Koichi
K
Sugahara
Takuya
T
Kishida
Taro
T
Koba
Yojiro
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
C530420:9-O,9'-O-demethylvirgatusin; D000900:Anti-Bacterial Agents; D001688:Biological Products; D005663:Furans; D017705:Lignans; C511226:virgatusin