Study of the mechanism of hemostatic effect of desmopressin.
Intravenous injection of 1 microg/kg desmopressin to rabbits not only accelerated clotting of arterial blood (maximally by 59.16 +/- 8.53% after 1 h), but also increased the number of microvesicles containing the integral enzyme 5'-nucleotidase in the arterial blood from the initial level of 36.26 +/- 8.08 ncat/liter to a maximum of 99.65 +/- 15.8 ncat/liter after 15 min.
Zubairov
D M
DM
Department of Biochemistry, Kazan State Medical University. dilja2001@mail.ru
Andrushko
I A
IA
Zubairova
L D
LD
Svintenok
G Yu
GY
D015720:5'-Nucleotidase / Q000097:blood; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D005169:Factor VIII / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D010959:Tissue Plasminogen Activator / Q000097:blood; D020302:Weibel-Palade Bodies / Q000187:drug effects / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
D014841:von Willebrand Factor; D005169:Factor VIII; D015720:5'-Nucleotidase; D010959:Tissue Plasminogen Activator; D003894:Deamino Arginine Vasopressin