title: Alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators.
authors.affiliation: Medicinal Chemistry, Psychiatry CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Lightfoot
authors.forename: James N C
authors.initials: JN
authors.lastname: Kew
authors.forename: John
authors.initials: J
authors.lastname: Skidmore
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D001523:Mental Disorders / Q000188:drug therapy; D018722:Nicotinic Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000502:physiology; D013329:Structure-Activity Relationship; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; C579167:Chrna7 protein, human; D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor