Molecular basis of gonadotropin receptor regulation.
The anterior pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), act upon the ovary and testis via occupancy of specific cell membrane receptors, resulting in increased cAMP production, steroidogenesis, and expression of differentiation-related genes. Recent cloning of the cDNAs for LH and FSH receptors allows the analysis of mRNA levels for these receptors in gonadal tissues. This review summarizes progress in elucidating the molecular basis of LH and FSH receptor gene regulation in the ovary and testis during different physiologic states.
Hsueh
A J
AJ
Aaron J. W. Hsueh and Philip S. LaPolt are at the Division of Reproductive Biology, Department of Gynecology and obstetrics, Stanford University School of Medicine, Stanford, CA 94305-5317, USA.
Lapolt
P S
PS