title: [Centrosome as "a brain" of an animal cell].
abstract: Centrosomes are the major centre of microtubule nucleation and microtubule minus-ends concentration in animal cells. Microtubule plus-ends are directed to a nucleus and chromosomes or to a cell cortex. The crossing of signal transduction pathways and the network of interactions between signal molecules controlling cell cycle are revealed in centrosomes. The ability of centrosomes for reduplication suggests the existence of hypothetic template elements. It is attractive to suggest the essential role of specific centrosome-associated RNAs in biogenesis of centrosomes. Untranslated RNAs playing a structural role and mRNAs that are localized in centrosomes to regulate protein synthesis in close proximity to mitotic apparatus may be present among these RNAs. Centrosomes positioning plays the important role in determining of cell polarity. Centrosomes are critical for the formation and support of cilia and flagella having motility or sensory functions.
authors.forename: L A
authors.initials: LA
authors.lastname: Mamon
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism; D002468:Cell Physiological Phenomena; D016764:Cell Polarity; D018385:Centrosome / Q000737:chemistry / Q000502:physiology*; D002923:Cilia / Q000502:physiology; D004398:Dyneins / Q000502:physiology; D005407:Flagella / Q000502:physiology; D008870:Microtubules / Q000378:metabolism; D010312:Parthenogenesis; D012313:RNA / Q000378:metabolism; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D012313:RNA; D004398:Dyneins