title: Modeling heaping in self-reported cigarette counts.
abstract: In studies of smoking behavior, some subjects report exact cigarette counts, whereas others report rounded-off counts, particularly multiples of 20, 10 or 5. This form of data reporting error, known as heaping, can bias the estimation of parameters of interest such as mean cigarette consumption. We present a model to describe heaped count data from a randomized trial of bupropion treatment for smoking cessation. The model posits that the reported cigarette count is a deterministic function of an underlying precise cigarette count variable and a heaping behavior variable, both of which are at best partially observed. To account for an excess of zeros, as would likely occur in a smoking cessation study where some subjects successfully quit, we model the underlying count variable with zero-inflated count distributions. We study the sensitivity of the inference on smoking cessation by fitting various models that either do or do not account for heaping and zero inflation, comparing the models by means of Bayes factors. Our results suggest that sufficiently rich models for both the underlying distribution and the heaping behavior are indispensable to obtaining a good fit with heaped smoking data. The analyses moreover reveal that bupropion has a significant effect on the fraction abstinent, but not on mean cigarette consumption among the non-abstinent.
authors.affiliation: Department of Biostatistics & Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA. haow@mail.med.upenn.edu
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Heitjan
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D001499:Bayes Theorem; D015982:Bias; D016642:Bupropion / Q000627:therapeutic use; D003625:Data Collection / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D016012:Poisson Distribution; D016032:Randomized Controlled Trials as Topic; D012907:Smoking; D016540:Smoking Cessation / Q000379:methods
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion