title: The use of nanoindentation for characterizing the properties of mineralized hard tissues: state-of-the art review.
abstract: The use of nanoindentation to determine nanomechanical properties of mineralized tissues has been investigated extensively. A detailed, critical, and comprehensive review of this literature is the subject of the present work. After stating the motivation for the review, a succinct presentation of the challenges, advantages, and disadvantages of the various quasi-static nanoindentation test methods (to obtain elastic modulus, E, and hardness, H) and dynamic test methods (to obtain storage and loss moduli and/or loss/damping factor) is given in the form of a primer. Explicative summaries of literature reports on various intrinsic and extrinsic factors that significantly influence E and H, followed by 15 suggested topics for future research, are included additionally. This review is designed to present a compact guide to the principles of the nanoindentation technique and to emphasize considerations when determining material properties of mineralized tissues.
authors.affiliation: Department of Mechanical Engineering, The University of Memphis, Memphis, Tennessee 38152, USA. glewis@memphis.edu
authors.forename: Gladius
authors.initials: G
authors.lastname: Lewis
authors.forename: Jeffry S
authors.initials: JS
authors.lastname: Nyman
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000502:physiology*; D002113:Calcification, Physiologic; D004548:Elasticity; D006245:Hardness Tests; D006801:Humans; D014070:Tooth / Q000502:physiology*