Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?
Circulating mesenchymal cells (cMCs) have a potential for regenerating damaged tissue, e.g., ischaemic myocardium. In patients (age range: 53-76 years) with stable coronary artery disease cMCs were determined before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n = 9 patients) or high intensity (>RCT) (n = 11). Only high-intensity exercise (i.e., provoking signs of myocardial ischaemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (p = 0.009). These results support the hypothesis that intense exercise (near or at the point of myocardial ischaemia) is a potent stimulus for MC mobilisation.
Lucia
A
A
Universidad Europea deMadrid, Spain. alejandro.lucia@uem.es
De La Rosa
A
A
Silván
M Avila
MA
López-Mojares
L M
LM
Boraita
A
A
Pérez
M
M
Foster
C
C
García-Castro
J
J
Ramirez
M
M
D000368:Aged; D002465:Cell Movement; D003324:Coronary Artery Disease / Q000534:rehabilitation*; D005081:Exercise Therapy / Q000379:methods*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D008875:Middle Aged; D016896:Treatment Outcome