title: [From the molecular model to the impact on prognosis: an overview on acute promyelocytic leukemia].
abstract: Acute promyelocytic leukemia (APL) is a model of clinical applicability of the knowledge of molecular physiopathology. It is characterized by recurrent genetic involvement of the retinoic acid alpha receptor. The consequence is a protein with low sensibility to its ligand and a myeloid maturation arrest. However, higher doses of all-trans-retinoic acid (ATRA) are able to supersede this deficiency and this is the mainstay of APL treatment leading to over 80% disease free survival, when adequately treated. Epidemiologically, it differs from other acute myeloid leukemia due to a higher incidence in young adults and in countries of "Latin" colonization. Differing from excellent results observed in developed countries, APL mortality in Brazil is still high, despite the wide availability of drugs.
authors.affiliation: Laboratório de Hematologia, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, SP, Brazil.
authors.forename: Rafael Henriques
authors.initials: RH
authors.lastname: Jácomo
authors.forename: Lorena Lobo de
authors.initials: LL
authors.lastname: Figueiredo-Pontes
authors.forename: Eduardo Magalhães
authors.initials: EM
authors.lastname: Rego
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D011379:Prognosis; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin