title: Effect of intrauterine infection and perinatal risk factors on serum concentrations of insulin like growth factor (IGF-I) in full-term and preterm newborns.
abstract: OBJECTIVE
  IGF-I is believed to be a key factor in fetal growth dynamics It is widely known, that serious early-onset infection in the newborn is a risk factor for further developmental disturbances in a child. However, effect of congenital infection as well as an influence of infectious and non-infectious perinatal risk factors on circulating IGF-I concentrations in newborns has not been examined, yet.
  
  
  METHODS
  Thus, the aim of this study was: 1) evaluation of IGF-I venous blood serum concentration in full-term and premature infants considering their sex, occurrence of intrauterine infection and perinatal risk factors; 2) establishing the relationship between IGF-I serum concentrations and chosen anthropometric parameters values in infected and healthy newborns.
  
  
  METHODS
  The study involved 112 newborns appropriate for gestational age. Taking into consideration occurrence of early onset infection and gestational age we divided examined children into 4 groups: I group--infected, full-term newborns; II group--infected premature newborns; III group--healthy full-term newborns; IV group--healthy premature newborns. In all infants immediately after birth anthropometric measurements were performed (birth weight, body length, circumference of head and circumference of chest) and serum IGF-I concentration was determined.
  
  
  RESULTS
  We demonstrated that full-term infants with intrauterine infection have statistically significantly higher concentration of IGF-I in blood serum than infected premature infants and healthy full-term infants. Analysis of correlation revealed a significant positive linear correlations between IGF-I serum concentration and gestational age and anthropometric parameters values.
  
  
  CONCLUSIONS
  We conclude that intrauterine infection increases serum IGF-I concentration in full-term infants, but not in preterm infants, that may be a result of immaturity. We suggest serum IGF-I concentration may be considered an additional element of developmental and nutritional state assessment in infected newborn.
authors.affiliation: Department of Paediatrics in Zabrze, Silesian University of Medicine in Katowice, Poland. smina@poczta.onet.pl
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Oświecimska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stojewska
authors.forename: Jakub
authors.initials: J
authors.lastname: Behrendt
authors.forename: Anna
authors.initials: A
authors.lastname: Pikiewicz-Koch
authors.forename: Katarzyna T
authors.initials: KT
authors.lastname: Ziora
authors.forename: Maria
authors.initials: M
authors.lastname: Szczepanska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Barc-Czarnecka
authors.forename: Urszula
authors.initials: U
authors.lastname: Godula-Stuglik
mesh_terms: D001724:Birth Weight; D001827:Body Height; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000209:etiology*; D007234:Infant, Premature / Q000097:blood*; D007239:Infections / Q000097:blood* / Q000151:congenital / Q000209:etiology; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood; D012307:Risk Factors; D047929:Term Birth
chemical_list: D007334:Insulin-Like Growth Factor I