title: Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and alpha-cyclodextrin.
abstract: This article reports a detailed study on the hydrogel formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers with alpha-cyclodextrin (alpha-CD) in aqueous solutions. The gelation kinetics and the gel rheological properties were studied using viscometry. The sol-gel phase transitions were studied using phase diagrams, while the gelation mechanism was studied using differential scanning calorimetric analysis. It was concluded that the gelation was induced by the complex formation between the PEO segments of the PEO-PPO-PEO triblock copolymer and alpha-CD, and the further self-assembly of the partially formed inclusion complexes. The addition of alpha-CD largely reduced the concentration of the copolymer needed for gel formation. The gels were thixotropic and reversible, and potentially suitable for use as an injectable drug-delivery system.
authors.affiliation: Institute of Materials Research and Engineering, National University of Singapore, 3 Research Link, Singapore 117602, Singapore.
authors.forename: Xiping
authors.initials: X
authors.lastname: Ni
authors.forename: Alan
authors.initials: A
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D014783:Viscosity; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D020100:Hydrogels; C116176:PEO-PPO-PEO; D011409:Propylene Glycols; D047391:alpha-Cyclodextrins; D011092:Polyethylene Glycols; C032613:alpha-cyclodextrin