title: Blastic mantle cell lymphoma with a Burkitt translocation.
abstract: MYC gene rearrangements are observed as a genetic change in the blastoid variant of mantle cell lymphoma (MCL). We present two patients, one had 30% atypical lymphocytes with Burkitt-like morphology in the peripheral blood and the other had 30% blasts in the bone marrow. Both had a CCND1/IGH and an MYC rearrangement by cytogenetics and FISH. The immunophenotype was CD5+[one was a weak positive], CD10+, CD20+, CCND1+, >90% Ki-67 proliferation fraction and CD23 negative. The diagnosis was blastic MCL with Burkitt features. These cases, along with the reported cases, distinguish an aggressive category of a blastic MCL with a poor prognosis that probably requires Burkitt therapy.
authors.affiliation: Genzyme Genetics, NY 10019, USA. kavita.reddy@gmail.com
authors.forename: Kavita
authors.initials: K
authors.lastname: Reddy
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ansari-Lari
authors.forename: Bruno
authors.initials: B
authors.lastname: Dipasquale
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002051:Burkitt Lymphoma / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic