[Expressions of interleukin 4 mRNA and interferonjgamma mRNA of condyloma acuminata].
OBJECTIVE
To study the expressions of interleukin 4 (IL-4) mRNA and interferon-gamma (IFN-gamma) mRNA of condyloma acuminata in order to obtain a clue as to the immunological mechanisms possibly relevant for warts regression or persistence.


METHODS
In situ RT-PCR was employed in surgically removed warts of 22 recurrent patients, 14 non-recurrent patients and 15 normal controls, respectively.


RESULTS
The expression of IFN-gamma mRNA in the non-recurrent warts was higher than in recurrent warts (P<0.01); but the expression of IL-4 mRNA in the recurrent warts was higher than in non-recurrent warts (P<0.01).


CONCLUSIONS
A higher IFN-gamma mRNA expression of condyloma acuminata lesions might contribute to warts regression.
Ma
Yong
Y
Department of Dermatology, NO.3 People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201900, China. mayong@126.com
Liu
Tong
T
D000328:Adult; D003218:Condylomata Acuminata / Q000235:genetics*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
D012333:RNA, Messenger; D015847:Interleukin-4; D007371:Interferon-gamma