title: Prognostic implications of the immunophenotype in biphenotypic acute leukemia.
abstract: The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.
authors.affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Je-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Yoo Hong
authors.initials: YH
authors.lastname: Min
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Chung
authors.forename: Byoung Kook
authors.initials: BK
authors.lastname: Kim
authors.forename: Hwi-Joong
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Deog-Yeon
authors.initials: DY
authors.lastname: Jo
authors.forename: Ho-Jin
authors.initials: HJ
authors.lastname: Shin
authors.forename: Soo-Mee
authors.initials: SM
authors.lastname: Bang
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Zang
authors.forename: Hyeoung Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Kyoo-Hyung
authors.initials: KH
authors.lastname: Lee
authors.forename: June-Won
authors.initials: JW
authors.lastname: Cheong
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Seonyang
authors.initials: S
authors.lastname: Park
authors.forename: Su Yon
authors.initials: SY
authors.lastname: Park
authors.forename: Joo Seop
authors.initials: JS
authors.lastname: Chung
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Chan-Jeoung
authors.initials: CJ
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007723:Korea; D015456:Leukemia, Biphenotypic, Acute / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis; D013601:T-Lymphocytes
chemical_list: D015415:Biomarkers