title: Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphoma.
abstract: Personal use of hair dye has been inconsistently linked to risk of non-Hodgkin lymphoma (NHL), perhaps because of small samples or a lack of detailed information on personal hair-dye use in previous studies. This study included 4,461 NHL cases and 5,799 controls from the International Lymphoma Epidemiology Consortium 1988-2003. Increased risk of NHL (odds ratio (OR) = 1.3, 95% confidence interval (CI): 1.1, 1.4) associated with hair-dye use was observed among women who began using hair dye before 1980. Analyses by NHL subtype showed increased risk for follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) but not for other NHL subtypes. The increased risks of FL (OR = 1.4, 95% CI: 1.1, 1.9) and CLL/SLL (OR = 1.5, 95% CI: 1.1, 2.0) were mainly observed among women who started using hair dyes before 1980. For women who began using hair dye in 1980 or afterward, increased FL risk was limited to users of dark-colored dyes (OR = 1.5, 95% CI: 1.1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded.
authors.affiliation: Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA. tongzhang.zheng@yale.edu
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Silvia De
authors.initials: SD
authors.lastname: Sanjose
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Becker
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadie
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Cocco
authors.forename: Anthony
authors.initials: A
authors.lastname: Staines
authors.forename: Theodore
authors.initials: T
authors.lastname: Holford
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Holly
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nieters
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Benavente
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Shelia Hoar
authors.initials: SH
authors.lastname: Zahm
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006202:Hair Dyes / Q000633:toxicity*; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000139:chemically induced / Q000453:epidemiology; D016015:Logistic Models; D008224:Lymphoma, Follicular / Q000139:chemically induced / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000453:epidemiology*; D012306:Risk; D011795:Surveys and Questionnaires
chemical_list: D006202:Hair Dyes