Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors.
Genomic sequencing was used to characterize most of the coding regions of the five two-domain stimulatory killer cell immunoglobulin-like receptor (KIR) loci from 80 unrelated, primarily Caucasian, individuals. Specific loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals. The number of known alleles present varied from one (KIR2DS1, KIR2DS5) to five (KIR2DS4). The frequencies of loci and alleles were similar to observations made in populations of European and Asian ethnicities. New alleles were found at 2DS1 (*00202, *00302, *005, *006, *007) and 2DS4 (*008) loci.
Hou
Lihua
L
Department of Pediatrics, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, Washington, DC, USA.
Steiner
Noriko K
NK
Chen
Minghua
M
Belle
Ian
I
Kubit
Anna L
AL
Ng
Jennifer
J
Hurley
Carolyn Katovich
CK
D000483:Alleles; D001402:B-Lymphocytes / Q000276:immunology*; D016026:Bone Marrow Transplantation; D002461:Cell Line, Transformed; D014644:Genetic Variation / Q000235:genetics*; D015698:Genomic Library; D006801:Humans; D016133:Polymerase Chain Reaction; D054340:Receptors, KIR / Q000235:genetics*
D054340:Receptors, KIR