title: Differences between women and men in serial HIV prevalence and incidence trends.
abstract: To measure trends in HIV incidence and serial prevalence by sex in a intravenous drug users (IDUs) and heterosexuals (HT) cohort recruited in a counselling centre in Valencia (1988-2005). Serial prevalence and incidence rates were calculated and modelled by logistic and Poisson regression respectively. 5948 IDUs and 13343 HT were recruited. Prevalence was higher among female IDUs (46% vs. 41%), and female HT (4.1% vs. 2%). For IDUs, an interaction (P = 0.005) between sex and calendar was detected. Age-adjusted prevalence showed faster yearly decline in men (OR = 0.87 95%CI: 0.85-0.88) than in women (OR = 0.91 95%CI: 0.88-0.93). Incidence was higher in female IDUs (9.79% p-y) than in men, (5.38% p-y) with an annual decrease for both of 11%. HIV incidence was higher in female HT (0.62% p-y) compared to men 0.23% p-y with a 21% yearly decline. Gender differences in HIV prevalence and incidence trends have been detected. Women showed an increased vulnerability to infection in a country whose HIV epidemic has been largely driven by IDUs.
authors.affiliation: Ciber en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. hurtado_isa@gva.es
authors.forename: Isabel
authors.initials: I
authors.lastname: Hurtado Navarro
authors.forename: I
authors.initials: I
authors.lastname: Alastrue
authors.forename: J
authors.initials: J
authors.lastname: Del Amo
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.forename: I
authors.initials: I
authors.lastname: Ferreros
authors.forename: T
authors.initials: T
authors.lastname: Tasa
authors.forename: S
authors.initials: S
authors.lastname: Pérez-Hoyos
mesh_terms: D015492:AIDS Serodiagnosis; D000293:Adolescent; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000453:epidemiology*; D020010:Heterosexuality; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*