title: Efficient approach to design stable water-dispersible nanoparticles of hydrophobic cellulose esters.
abstract: Commercially prepared cellulose acetate, cellulose acetate propionate, -butyrate, and -phthalate as well as cellulose acetates prepared in the laboratory scale with varying degree of substitution (DS) self-assemble into regular nanoparticles, ranging in size from 86 to 368 nm, by using two different techniques of nanoprecipitation. Dialysis of polymers dissolved in N,N-dimethylacetamide results in the formation of regular nanospheres whereas the preparation in acetone by successive adding of water leads to bean-shaped particles in the nanoscale. One criterion for nanoprecipitation is the existence of dilute polymer solutions. Furthermore, the formation of nanoparticles strongly depends on DS and distribution of the substituents. Concerning this issue, quantitative (13)C NMR spectroscopy was applied for detailed structure characterization of selected cellulose acetates. The stability of the nanoparticle suspensions in the physiological pH range was observed by zeta potential measurements.
authors.affiliation: Center of Excellence for Polysaccharide Research, Friedrich Schiller University of Jena, D-07743 Jena, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hornig
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D011232:Chemical Precipitation; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D014867:Water
chemical_list: D014867:Water; C005062:acetylcellulose; D002482:Cellulose