Familial dyskeratotic comedones.
Familial dyskeratotic comedones (FDC) is a rare autosomal dominant inherited condition, characterized by widespread, symmetrically scattered, comedone-like, hyperkeratotic papules, which are cosmetically unappealing. These lesions appear around puberty and show a predilection to involve the trunk, arms and face. The lesions are asymptomatic and gradually worsen with time. Histology shows invagination of the epidermis with a lamellar keratinous plug and focal evidence of dyskeratosis. This condition is generally refractory to therapy. We report here two cases with this rare disorder who had a strong familial history of the same disorder.
Kumaran
M Sendhil
MS
Department of Dermatology, St. Johns Medical College Hospital, Bangalore, India. drsen_2000@yahoo.com
Appachu
Divya
D
Jayaseelan
Elizabeth
E
D000328:Adult; D005260:Female; D006801:Humans; D007642:Keratosis / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male