Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.
The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter. In this report, we investigate the role of JDP2 (Jun Dimerization Protein 2) in the amino acid control of CHOP transcription following amino acid starvation. Our results show that JDP2 binds to the CHOP AARE in unstimulated cells and that its binding decreases following amino acid starvation. We demonstrate that JDP2 acts as a repressor and suggest that it could be functionally associated with HDAC3 to inhibit CHOP transcription.
Chérasse
Yoan
Y
UMR 1019 of Human Nutrition, INRA de Theix, 63122 Saint Genès Champanelle, France.
Chaveroux
Cédric
C
Jousse
Céline
C
Maurin
Anne-Catherine
AC
Carraro
Valérie
V
Parry
Laurent
L
Fafournoux
Pierre
P
Bruhat
Alain
A
D019281:Dimerization; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D006367:HeLa Cells; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007930:Leucine / Q000378:metabolism; D008156:Luciferases / Q000235:genetics; D012097:Repressor Proteins / Q000502:physiology*; D051742:Transcription Factor CHOP / Q000235:genetics*; D014158:Transcription, Genetic; D000099186:Histone Deacetylase 3
D006655:Histone Deacetylases; D007930:Leucine; D008156:Luciferases; D012097:Repressor Proteins; D051742:Transcription Factor CHOP; D000099186:Histone Deacetylase 3; C497249:DDIT3 protein, human; C491387:JDP2 protein, human