title: The great divide: coordinating cell cycle events during bacterial growth and division.
abstract: The relationship between events during the bacterial cell cycle has been the subject of frequent debate. While early models proposed a relatively rigid view in which DNA replication was inextricably coupled to attainment of a specific cell mass, and cell division was triggered by the completion of chromosome replication, more recent data suggest these models were oversimplified. Instead, an intricate set of intersecting, and at times opposing, forces coordinate DNA replication, cell division, and cell growth with one another, thereby ensuring the precise spatial and temporal control of cell cycle events.
authors.affiliation: Department of Biology, Washington University, St. Louis, MO 63130, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Haeusser
authors.forename: Petra Anne
authors.initials: PA
authors.lastname: Levin
mesh_terms: D001412:Bacillus subtilis / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D002455:Cell Division; D020090:Chromosome Segregation; D004261:DNA Replication; D004926:Escherichia coli / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial
chemical_list: D001426:Bacterial Proteins