Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry).
Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)tyramine, cannabisin G and (+/-)-lyoniresinol. Of these, cannabisin G and (+/-)-lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide.
Tomosaka
Hideyuki
H
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 W. 12th Ave., Columbus, Ohio 43210, USA.
Chin
Young-Won
YW
Salim
Angela A
AA
Keller
William J
WJ
Chai
Heebyung
H
Kinghorn
A Douglas
AD
D000840:Anisoles / Q000032:analysis / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D028142:Berberis / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005591:Chemical Fractionation; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000032:analysis / Q000494:pharmacology*; D019610:Cytoprotection; D016166:Free Radical Scavengers; D006801:Humans; D017665:Hydroxyl Radical; D009281:Naphthalenes / Q000032:analysis / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
D000840:Anisoles; D000975:Antioxidants; D003373:Coumaric Acids; D016166:Free Radical Scavengers; C001411:N-(4-hydroxy-beta-phenethyl)-4-hydroxycinnamide; D009281:Naphthalenes; D010636:Phenols; D010936:Plant Extracts; C093865:cannabisin G; C502379:lyoniresinol; D017665:Hydroxyl Radical