title: Molecular Properties of the CRF Receptor.
abstract: Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF-R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.
authors.affiliation: Max-Planck Institute for Experimental Medicine, Department of Molecular Neuroendocrinology, Hermann-Rein-Strasse 3, 37075 Goettingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Spiess
authors.forename: F M
authors.initials: FM
authors.lastname: Dautzenberg
authors.forename: S
authors.initials: S
authors.lastname: Sydow
authors.forename: R L
authors.initials: RL
authors.lastname: Hauger
authors.forename: A
authors.initials: A
authors.lastname: Rühmann
authors.forename: T
authors.initials: T
authors.lastname: Blank
authors.forename: J
authors.initials: J
authors.lastname: Radulovic