title: Pustulosis acuta generalisata with joint involvement in an HLA-A2- and HLA-B35-positive patient.
abstract: Pustulosis acuta generalisata (PAG) is a rare poststreptococcal disease of the skin, which has been reported in children and adults after streptococcal throat infection. Herein, we report on the case of a 47-year-old woman with typical clinical and histologic findings of PAG emerging after a pharyngeal infection in whom inflammatory joint-involvement developed. The patient was found to be HLA-A2 and HLA-B35 positive. Whereas HLA-B35 might be associated with pustular skin diseases, HLA-A2 is a risk factor for the development of rheumatoid arthritis.
authors.affiliation: Department of Dermatology, Venerology und Allergology, University of Cologne, Cologne, Germany.
authors.forename: Mittra
authors.initials: M
authors.lastname: Eren
authors.forename: Mario
authors.initials: M
authors.lastname: Fabri
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
authors.forename: Sabine A
authors.initials: SA
authors.lastname: Eming
mesh_terms: D000208:Acute Disease; D001168:Arthritis / Q000097:blood / Q000150:complications*; D005260:Female; D015789:HLA-A2 Antigen / Q000097:blood*; D015797:HLA-B35 Antigen / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000097:blood / Q000150:complications* / Q000175:diagnosis*
chemical_list: D015789:HLA-A2 Antigen; D015797:HLA-B35 Antigen