title: Effects of an expanded cardiac rehabilitation programme in patients treated for an acute myocardial infarction or a coronary artery by-pass graft operation.
abstract: OBJECTIVE
  To investigate the effects of expanded cardiac rehabilitation with multifactorial interventions on metabolic and inflammatory markers, exercise performance and on established cardiovascular risk factors.
  
  
  METHODS
  Single-centre prospective randomized controlled trial.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  Two hundred and twenty-four patients with an acute myocardial infarction or patients undergoing coronary artery by-pass grafting.
  
  
  METHODS
  Patients were randomized to expanded cardiac rehabilitation including stress management, increased physical training, staying at a 'patient hotel' and cooking sessions, or to usual cardiac rehabilitation.
  
  
  METHODS
  Biochemical risk markers and exercise performance; follow-up was one year.
  
  
  RESULTS
  There were no significant differences between the two treatment groups in the changes of biochemical risk markers or in exercise performance. Thus, low-density lipoprotein (LDL)-cholesterol levels decreased from 3.00 (0.97) to 2.54 (0.66) mmol/L in the intervention group and from 3.20 (0.85) to 2.54 (0.63) mmol/L in the control group, fibrinogen levels decreased from 5.30 (2.00) to 4.25 (1.01) g/L in the intervention group and from 5.29 (1.89) to 4.33 (0.83) g/L in the control group and C-reactive protein (CRP) levels decreased from 3.04 (2.79) to 2.09 (2.13) mg/L in the intervention group and from 4.01 (3.49) to 2.39 (2.49) mg/L in the control group. Total workload (W) improved from 118 (35) to 136 (34) in the intervention group and from 117 (36) to 133 (39) in the control group.
  
  
  CONCLUSIONS
  There was no further significant benefit in biochemical risk markers or in exercise performance among patients undergoing the expanded rehabilitation as compared to the control group which received usual cardiac rehabilitation.
authors.affiliation: Karolinska Institutet, Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd Hospital, Stockholm, Sweden. catrine.edstrom@ds.se
authors.forename: C Edström
authors.initials: CE
authors.lastname: Plüss
authors.forename: M Rydell
authors.initials: MR
authors.lastname: Karlsson
authors.forename: N  H
authors.initials: N
authors.lastname: Wallen
authors.forename: E
authors.initials: E
authors.lastname: Billing
authors.forename: C
authors.initials: C
authors.lastname: Held
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D001026:Coronary Artery Bypass / Q000534:rehabilitation*; D004032:Diet; D005080:Exercise Test; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking; D013315:Stress, Psychological / Q000628:therapy
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D005340:Fibrinogen; D002097:C-Reactive Protein