title: Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles.
abstract: We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SNAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,N-disubstituted 2-amino-1,3,4-oxadiazoles, which are difficult to prepare using existing synthetic strategies.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, Cambridge, MA 02140, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Levins
authors.forename: Zhao-Kui
authors.initials: ZK
authors.lastname: Wan
mesh_terms: D000586:Amination; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009943:Organophosphorus Compounds; D010069:Oxadiazoles; C031032:benzotriazol-1-yloxy-tris(dimethylamino)phosphonium