Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.
OBJECTIVE
The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.


METHODS
We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.


RESULTS
Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5+/-5.2 ng/mL vs. 20.0+/-7.3 ng/mL, P<0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (P<0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (rho=0.458, P<0.05) and HOMA-R (rho=0.444, P<0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (F=5.294, P<0.05) in female patients with diabetes.


CONCLUSIONS
These findings suggest that BDNF may contribute to glucose metabolism.
Fujinami
Aya
A
Department of Medical Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyama-kita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
Ohta
Kiyoe
K
Obayashi
Hiroshi
H
Fukui
Michiaki
M
Hasegawa
Goji
G
Nakamura
Naoto
N
Kozai
Hana
H
Imai
Saeko
S
Ohta
Mitsuhiro
M
D052242:Adiponectin / Q000097:blood; D000368:Aged; D000419:Albuminuria; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012016:Reference Values
D052242:Adiponectin; D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D007328:Insulin; D020738:Leptin; D003404:Creatinine