title: Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?
abstract: Circulating mesenchymal cells (cMCs) have a potential for regenerating damaged tissue, e.g., ischaemic myocardium. In patients (age range: 53-76 years) with stable coronary artery disease cMCs were determined before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n = 9 patients) or high intensity (>RCT) (n = 11). Only high-intensity exercise (i.e., provoking signs of myocardial ischaemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (p = 0.009). These results support the hypothesis that intense exercise (near or at the point of myocardial ischaemia) is a potent stimulus for MC mobilisation.
authors.affiliation: Universidad Europea deMadrid, Spain. alejandro.lucia@uem.es
authors.forename: A
authors.initials: A
authors.lastname: Lucia
authors.forename: A
authors.initials: A
authors.lastname: De La Rosa
authors.forename: M Avila
authors.initials: MA
authors.lastname: Silván
authors.forename: L M
authors.initials: LM
authors.lastname: López-Mojares
authors.forename: A
authors.initials: A
authors.lastname: Boraita
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: C
authors.initials: C
authors.lastname: Foster
authors.forename: J
authors.initials: J
authors.lastname: García-Castro
authors.forename: M
authors.initials: M
authors.lastname: Ramirez
mesh_terms: D000368:Aged; D002465:Cell Movement; D003324:Coronary Artery Disease / Q000534:rehabilitation*; D005081:Exercise Therapy / Q000379:methods*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D008875:Middle Aged; D016896:Treatment Outcome