Twenty-three novel alleles increase diversity at the HLA-C locus.
Twenty-three novel HLA-C alleles are described. Nine of the new alleles are single-nucleotide substitutions from their most homologous allele of which seven result in amino acid changes (Cw*0327, *0508, *0514, *0613, *0735, *0739 and *1517) and two are silent substitutions (Cw*030305 and *070107). The remaining 14 alleles (Cw*0113, *0207, *0212, *0216, *0318, *0411, *0417, *0512, *0722, *0733N, *1216, *1218, *1515 and *1607) differ from their most similar alleles by 2-4 nucleotide substitutions that result in 1-3 amino acid differences.
Lazaro
A M
AM
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA. poschp@georgetown.edu
Xiao
Y
Y
Cao
K
K
Masaberg
C
C
Nichol
L
L
Ng
J
J
Hurley
C K
CK
Posch
P E
PE
D000483:Alleles; D019943:Amino Acid Substitution; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D040641:Quantitative Trait Loci
D015236:HLA-C Antigens