Contributions of the response regulators Ssk1p and Skn7p in the pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.
We recently characterized the histidine kinase receptor genes of Candida lusitaniae. For the present study, we have further investigated the role of SSK1 and SKN7, encoding response regulators. The results of functional analysis of mutants indicated that Ssk1p is involved in osmotolerance and pseudohyphal development, whereas Skn7p appears crucial for oxidative stress adaptation.
Ruprich-Robert
Gwenaël
G
UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 Avenue de l'Observatoire, 75006 Paris, France.
Chapeland-Leclerc
Florence
F
Boisnard
Stéphanie
S
Florent
Martine
M
Bories
Gaël
G
Papon
Nicolas
N
D002175:Candida / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology*; D018384:Oxidative Stress; D015398:Signal Transduction
D005656:Fungal Proteins; C487633:SSK1 protein, Candida albicans