title: Myeloproliferative disorder as the cause of peripheral ischemia in a young patient.
abstract: A 35-year-old patient with rest pain and peripheral gangrene was referred with a diagnosis of Takayasu's disease but had myeloproliferative disorder (primary thrombocythemia). The angiogram revealed surgically noncorrectable small vessel occlusive disease with no evidence of atheroma. Medical therapy with cytotoxic and antiplatelet agents achieved satisfactory results with excellent wound healing after surgical amputation of necrotic tissue. The need for early diagnosis of this condition is emphasized.
authors.affiliation: Department of Vascular Surgery, St. Mary's Hospital, London, UK. j.hon@ic.ac.uk
authors.forename: Jimmy K F
authors.initials: JK
authors.lastname: Hon
authors.forename: Andre
authors.initials: A
authors.lastname: Chow
authors.forename: Saad
authors.initials: S
authors.lastname: Abdalla
authors.forename: John H
authors.initials: JH
authors.lastname: Wolfe
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D015901:Angiography, Digital Subtraction; D001241:Aspirin / Q000627:therapeutic use; D005734:Gangrene; D006401:Hematologic Agents / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007511:Ischemia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009196:Myeloproliferative Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D010146:Pain / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D059408:Pain Management; D010147:Pain Measurement; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013920:Thrombocythemia, Essential / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D014034:Toes / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D006401:Hematologic Agents; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D006918:Hydroxyurea