title: Impact of percutaneous nephrolithotomy on estimated glomerular filtration rate in patients with chronic kidney disease.
abstract: OBJECTIVE
  We investigated the impact of percutaneous renal procedures on estimated glomerular filtration rate (GFR) of patients with chronic kidney disease (CKD).
  
  
  METHODS
  The GFRs of adult patients were calculated using the Modification of Diet in Renal Disease formula, and the patients were staged according to the Kidney Disease Outcome Quality Initiative CKD classification system. The study included 185 patients with preoperative GFR values less than 60 mL/min/1.73 m(2). The impact of percutaneous nephrolithotomy (PCNL) on GFR was analyzed by comparing the preoperative GFR with the GFR before discharge and at postoperative month 3.
  
  
  RESULTS
  Patients with CKD had a significant increase in the GFR after the procedure. In postoperative month 3, the mean GFR was more than 60 mL/min/1.73 m(2) in 25% of the patients with CKD and less than 60 mL/min/1.73 m(2) in 75%. While all patients with stage 5 CKD improved to better stages, some other patients' conditions declined to stage 5 from better stages at the end of postoperative month 3. No patient needed dialysis. The presence of urinary tract infections tended to affect GFR negatively.
  
  
  CONCLUSIONS
  Estimated GFR, as a better indicator of renal function, is significantly affected by the PCNL procedure. While significant improvement was observed in late-stage patients with CKD, unexpected deterioration could occur in patients at earlier stages.
authors.affiliation: Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey. cybilen@yahoo.com
authors.forename: Cenk Y
authors.initials: CY
authors.lastname: Bilen
authors.forename: Kubilay
authors.initials: K
authors.lastname: Inci
authors.forename: Burak
authors.initials: B
authors.lastname: Kocak
authors.forename: Bekir
authors.initials: B
authors.lastname: Tan
authors.forename: Saban
authors.initials: S
authors.lastname: Sarikaya
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sahin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007669:Kidney Calculi / Q000628:therapy; D007674:Kidney Diseases / Q000145:classification / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous; D011183:Postoperative Complications; D011184:Postoperative Period; D011300:Preoperative Care; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014514:Ureteral Calculi / Q000628:therapy; D014552:Urinary Tract Infections / Q000150:complications