Comparison of monotherapy versus combination antihypertensive therapy in elderly patients with essential hypertension.
Authors sought to compare the efficacy of monotherapy versus combination antihypertensive therapy in elderly patients. Patients in this study, aged 65 to 85 years, were divided into 4 groups and entered an 8-week treatment period. First group: 22 patients, amlodipine 5 mg/d increasing to 10 mg; second: 20 patients, eprosartan 600 mg/d increasing to 600 mg twice a day; third: 21 patients, amlodipine 5 mg/d and indapamide 2.5 mg/d, increasing amlodipine to 10 mg/d; fourth: 23 patients, imidapril 10 mg/d and indapamide 2.5 mg/d, imidapril doubled to 20 mg/d. A greater drop in systolic and in diastolic blood pressure was obtained by combination of amlodipine and indapamide compared with amlodipine or eprosartan monotherapy. Imidapril and indapamide showed similar efficacy compared with eprosartan monotherapy but not with amlodipine monotherapy. Amlodipine and indapamide appeared more effective than imidapril and indapamide in diastolic blood pressure. Combination treatment with amlodipine and indapamide or imidapril and indapamide effectively reduces blood pressure in elderly patients with essential hypertension.
Antonopoulos
Stavros
S
2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens, Greece.
Kokkoris
Stelios
S
Gerakari
Styliani
S
Mikros
Sotirios
S
Nitsotolis
Thomas
T
Vikeli
Despina
D
Korantzopoulos
Panagiotis
P
Giannoulis
Gregory
G
D000179:Acrylates / Q000008:administration & dosage; D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003971:Diastole / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007093:Imidazoles / Q000008:administration & dosage; D048289:Imidazolidines / Q000008:administration & dosage; D007190:Indapamide / Q000008:administration & dosage; D008297:Male; D013599:Systole / Q000187:drug effects; D013876:Thiophenes / Q000008:administration & dosage; D016896:Treatment Outcome
D000179:Acrylates; D000959:Antihypertensive Agents; D007093:Imidazoles; D048289:Imidazolidines; D013876:Thiophenes; D017311:Amlodipine; C068373:eprosartan; C065166:imidapril; D007190:Indapamide