title: Aminoterminal pro-brain natriuretic peptide (NT-proBNP) and sleep-disordered breathing in morbidly obese females: a cross-sectional study.
abstract: Sleep-disordered breathing (SDB) is often encountered in morbid obesity (MO) in conjunction with insulin resistance (IR). Aminoterminal pro-brain natriuretic peptide (NT-proBNP) is a promising marker for left ventricular dysfunction (LVD) in MO. We sought to explore the factors that may influence the relationships of SDB and IR with NT-proBNP in MO women. We performed a cross-sectional pilot study involving 110 asymptomatic MO (44.5+/-0.7 kg/m2) young women. SDB risk was assessed using a modified version of the Berlin Questionnaire (BQ). IR was assessed using the homeostasis model assessment (HOMA) index and adiponectin levels. LVD was assessed using NT-proBNP and echocardiograms. In this study, NT-proBNP levels and LVD increased significantly along the BQ strata. Multiple regression analysis identified BQ and log-transformed HOMA as the independent variables predicting as much as 48.0% of the variability of logNT-proBNP. In conclusion, NT-pro-BNP levels are independently predicted by SDB and IR in asymptomatic MO women. Larger prospective studies are warranted.
authors.affiliation: Instituto de Cardiología y Medicina Avanzada , Centro Médico Teknon, C/ Vilana 12, 08021 Barcelona, Spain. juanybarra@hotmail.com
authors.forename: Juan
authors.initials: J
authors.lastname: Ybarra
authors.forename: Francesc
authors.initials: F
authors.lastname: Planas
authors.forename: Jose M
authors.initials: JM
authors.lastname: Pou
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood / Q000150:complications*; D010446:Peptide Fragments / Q000097:blood*; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000150:complications*; D011795:Surveys and Questionnaires; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain