[Treatment of radiation burns with surgery and cell therapy. A report of two cases].
Treatment of severe radiation burns remains a difficult challenge. Conventional surgical treatment (excision, skin grafting, skin or muscle flaps) often fails to prevent unpredictable and uncontrolled extension of the necrotic process. We report two clinical cases in which surgery was combined with mesenchymal stem cell (MSC) therapy. Clinical outcome was good and there was no recurrence of radiation inflammatory waves observed in the first patient after one year. This novel multi-disciplinary therapeutic approach, combining physical techniques, modern plastic surgery and cell therapy should improve the medical management of severe localized radiation burns.
Bey
Eric
E
Service de Chirurgie Plastique H.I.A. Percy 100 avenue H. Barbusse 92141 Clamart.
Duhamel
Patrick
P
Lataillade
Jean-Jacques
JJ
de Revel
Thierry
T
Carsin
Hervé
H
Gourmelon
Patrick
P
D000328:Adult; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology / Q000601:surgery* / Q000628:therapy*; D044968:Regenerative Medicine; D013997:Time Factors; D016896:Treatment Outcome