title: Many sequence variants affecting diversity of adult human height.
abstract: Adult human height is one of the classical complex human traits. We searched for sequence variants that affect height by scanning the genomes of 25,174 Icelanders, 2,876 Dutch, 1,770 European Americans and 1,148 African Americans. We then combined these results with previously published results from the Diabetes Genetics Initiative on 3,024 Scandinavians and tested a selected subset of SNPs in 5,517 Danes. We identified 27 regions of the genome with one or more sequence variants showing significant association with height. The estimated effects per allele of these variants ranged between 0.3 and 0.6 cm and, taken together, they explain around 3.7% of the population variation in height. The genes neighboring the identified loci cluster in biological processes related to skeletal development and mitosis. Association to three previously reported loci are replicated in our analyses, and the strongest association was with SNPs in the ZBTB38 gene.
authors.affiliation: deCODE Genetics, 101 Reykjavik, Iceland. daniel.gudbjartsson@decode.is
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gudbjartsson
authors.forename: G Bragi
authors.initials: GB
authors.lastname: Walters
authors.forename: Gudmar
authors.initials: G
authors.lastname: Thorleifsson
authors.forename: Hreinn
authors.initials: H
authors.lastname: Stefansson
authors.forename: Bjarni V
authors.initials: BV
authors.lastname: Halldorsson
authors.forename: Pasha
authors.initials: P
authors.lastname: Zusmanovich
authors.forename: Patrick
authors.initials: P
authors.lastname: Sulem
authors.forename: Steinunn
authors.initials: S
authors.lastname: Thorlacius
authors.forename: Arnaldur
authors.initials: A
authors.lastname: Gylfason
authors.forename: Stacy
authors.initials: S
authors.lastname: Steinberg
authors.forename: Anna
authors.initials: A
authors.lastname: Helgadottir
authors.forename: Andres
authors.initials: A
authors.lastname: Ingason
authors.forename: Valgerdur
authors.initials: V
authors.lastname: Steinthorsdottir
authors.forename: Elinborg J
authors.initials: EJ
authors.lastname: Olafsdottir
authors.forename: Gudridur H
authors.initials: GH
authors.lastname: Olafsdottir
authors.forename: Thorvaldur
authors.initials: T
authors.lastname: Jonsson
authors.forename: Knut
authors.initials: K
authors.lastname: Borch-Johnsen
authors.forename: Torben
authors.initials: T
authors.lastname: Hansen
authors.forename: Gitte
authors.initials: G
authors.lastname: Andersen
authors.forename: Torben
authors.initials: T
authors.lastname: Jorgensen
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.forename: Katja K
authors.initials: KK
authors.lastname: Aben
authors.forename: J Alfred
authors.initials: JA
authors.lastname: Witjes
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: Martin
authors.initials: M
authors.lastname: den Heijer
authors.forename: Barbara
authors.initials: B
authors.lastname: Franke
authors.forename: Andre L M
authors.initials: AL
authors.lastname: Verbeek
authors.forename: Diane M
authors.initials: DM
authors.lastname: Becker
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Yanek
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Becker
authors.forename: Laufey
authors.initials: L
authors.lastname: Tryggvadottir
authors.forename: Thorunn
authors.initials: T
authors.lastname: Rafnar
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gulcher
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D000328:Adult; D001827:Body Height / Q000235:genetics*; D001846:Bone Development / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008297:Male; D008938:Mitosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D012097:Repressor Proteins; C508975:ZBTB38 protein, human