Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for alpha-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.
Kordower
Jeffrey H
JH
Department of Neurological Sciences and Center for Brain Repair, Rush University Medical Center, 1735 West Harrison Street, Chicago, Illinois 60612, USA. jkordowe@rush.edu
Chu
Yaping
Y
Hauser
Robert A
RA
Freeman
Thomas B
TB
Olanow
C Warren
CW
D016380:Brain Tissue Transplantation / Q000379:methods / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D013378:Substantia Nigra / Q000473:pathology; D016896:Treatment Outcome; D025801:Ubiquitin / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism
D025801:Ubiquitin; D051844:alpha-Synuclein