The SRY gene.
SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination. This review covers the structure of the SRY gene and its RNA transcripts, along with evidence equating SRY with the mammalian testis-determining factor, its evolution, and biochemical aspects of the SRY protein.
Hawkins
J R
JR
Department of Genetics, Cambridge University, Cambridge CB2 3EH, England.