Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials.
Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.
Moon
James J
JJ
Department of Bioengineering, Rice University, P.O. Box 1892, MS 142, Houston, Texas 77251-1892, USA.
West
Jennifer L
JL
D000818:Animals; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D042783:Endothelial Cells; D016326:Extracellular Matrix Proteins / Q000737:chemistry; D006801:Humans; D018919:Neovascularization, Physiologic; D010455:Peptides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D016326:Extracellular Matrix Proteins; D010455:Peptides; D011108:Polymers