title: New, general, and practical preparation of methyl ketones via the direct coupling of amides with CH2Cl2 promoted by TiCl4/Mg.
abstract: The direct coupling of a variety of amides with CH2 Cl2 or CD2 Cl2 promoted by TiCl 4/Mg/THF provides an extremely simple, practical, selective, and efficient approach for the construction of methyl ketones. The efficiency and practicability of this chemistry is illustrated by the very simple synthesis of deuterated methyl ketones.
authors.affiliation: Department of Chemistry, National Chung-Hsing University, Taichung 400, Taiwan, Republic of China.
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Lin
authors.forename: Chi-Hui
authors.initials: CH
authors.lastname: Tsai
authors.forename: I-Lin
authors.initials: IL
authors.lastname: Hsieh
authors.forename: Tu-Hsin
authors.initials: TH
authors.lastname: Yan
mesh_terms: D000577:Amides / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000577:Amides; D007659:Ketones; D008752:Methylene Chloride; C025096:titanium tetrachloride; D014025:Titanium; D008274:Magnesium