title: Label-free optical biosensing with slot-waveguides.
abstract: We demonstrate label-free molecule detection by using an integrated biosensor based on a Si(3)N(4)/SiO(2) slot-waveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm/(ng/mm(2)) for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg/mm(2) for anti-BSA and BSA, respectively, limited by wavelength resolution.
authors.affiliation: Instituto de Sistemas Optoelectrónicos y Microtecnología, Universidad Politécnica de madrid, ETSI Telecommunicación, Ciudad Universitaria s/n, Madrid, Spain. cbarrios@die.upm.es
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Barrios
authors.forename: María José
authors.initials: MJ
authors.lastname: Bañuls
authors.forename: Victoria
authors.initials: V
authors.lastname: González-Pedro
authors.forename: Kristinn B
authors.initials: KB
authors.lastname: Gylfason
authors.forename: Benito
authors.initials: B
authors.lastname: Sánchez
authors.forename: Amadeu
authors.initials: A
authors.lastname: Griol
authors.forename: A
authors.initials: A
authors.lastname: Maquieira
authors.forename: H
authors.initials: H
authors.lastname: Sohlström
authors.forename: M
authors.initials: M
authors.lastname: Holgado
authors.forename: R
authors.initials: R
authors.lastname: Casquel
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D002417:Cattle; D002623:Chemistry Techniques, Analytical / Q000379:methods; D004867:Equipment Design; D007834:Lasers; D055095:Optics and Photonics; D012680:Sensitivity and Specificity; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013053:Spectrophotometry / Q000379:methods
chemical_list: D012710:Serum Albumin, Bovine