Subinhibitory concentrations of antibiotics induce phenazine production in a marine Streptomyces sp.
Subinhibitory concentrations of antibiotics were found to enhance and modulate the production of new phenazines, streptophenazines A-H, in a marine Streptomyces isolate. The streptophenazines differ in length and substitution of an alkyl chain. The pattern of metabolites formed depends on the antibiotic used. In the presence of tetracycline, streptophenazines F and G were induced and the production of streptophenazines A-D was increased. When using bacitracin, mainly streptophenazine H was produced. Streptophenazines C and H showed moderate activity against Bacillus subtilis, while streptophenazine C was also active against Staphylococcus lentus.
Mitova
Maya I
MI
Kieler Wirkstoff-Zentrum KiWiZ am Leibniz-Institut für Meereswissenschaften (IFM-GEOMAR), Kiel, Germany. mitova_maya@yahoo.it
Lang
Gerhard
G
Wiese
Jutta
J
Imhoff
Johannes F
JF
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D010619:Phenazines