Regio- and diastereo-selectivity of montmorillonite-catalyzed oligomerization of racemic adenosine 5'-phosphorimidazolide.
Clay is a possible candidate for an effective catalyst in prebiotic chemical evolution of biomolecules. Montmorillonite was reported to effectively catalyze oligomerization of racemic adenosine 5'-phosphorimidazolide (DL-ImpA). In the oligomerization reaction, considerable amounts of cyclic dimers as well as linear dimers were produced in the oligomerization reactions. To assess the regio- and diastereo-selectivities of the oligomerization reaction, the dimer products including cyclic dimers were completely identified by means of enzymatic degradation reactions of the products.
Urata
Hidehito
H
Osaka University of Pharmaceutical Sciences, Osaka, Japan. urata@gly.oups.ac.jp
Fujimori
Mami
M
Aono
Chie
C
Yamakawa
Tomomi
T
Harada
Emi
E
Akagi
Masao
M
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000538:Aluminum Silicates / Q000378:metabolism; D001546:Bentonite / Q000378:metabolism*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D000077215:Clay; D019281:Dimerization; D004722:Endoribonucleases / Q000378:metabolism; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013379:Substrate Specificity
D000538:Aluminum Silicates; D007093:Imidazoles; C520193:adenosine 5'-phosphorimidazolide; D001546:Bentonite; D000249:Adenosine Monophosphate; D004722:Endoribonucleases; C022543:ribonuclease T(2); D000077215:Clay