The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase.
The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.
Shin
Jae-Ho
JH
School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Republic of Korea.
Heo
Gun Young
GY
Kelman
Zvi
Z
D019843:Archaeal Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002876:Chromosomes, Bacterial; D004265:DNA Helicases / Q000378:metabolism*; D019848:Gene Expression Regulation, Archaeal / Q000502:physiology; D017013:Methanobacteriaceae / Q000378:metabolism*
D019843:Archaeal Proteins; D018797:Cell Cycle Proteins; D004265:DNA Helicases