In vitro fertilization is expensive: when should a couple be advised to stop trying with their own gametes and seek other options? Review of three cases.
OBJECTIVE
To describe refractory infertility cases that preserved many failed in vitro fertilization (IVF) cycles to achieve the goal of delivering a baby.


METHODS
Case reports with a description of the various approaches and change in strategy that finally led to success.


RESULTS
Factors causing repeated failures in these cases included adverse effects of the controlled ovarian hyperstimulation regimen on the uterine environment, failure to realize that the sperm from a male with a low hypo-osmotic swelling test can cause embryo implantation failure unless intracytoplasmic sperm injection is performed, and the discovery that sperm abnormalities rather than exclusively oocyte problems can lead to embryo fragmentation.


CONCLUSIONS
It is imperative that infertility specialists individualize cases--especially ones that have failed several cycles--and stop using the same process that has repeatedly failed. They should stop and think if there are some less common but important factors they may have overlooked. Merely recommending donor oocytes without exploring other options is inappropriate.
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D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010817:Physician-Patient Relations; D011247:Pregnancy; D018873:Pregnancy Rate; D011361:Professional Competence; D027724:Reproductive Techniques, Assisted; D017211:Treatment Failure