title: Outcome after renal transplantation. Part I: intellectual and motor performance.
abstract: Comprehensive information on neurodevelopmental outcome in children and adolescents with chronic kidney disease is still limited. Intellectual performance (IP) and motor performance (MP) were systematically assessed in 27 patients at a median age of 14.1 years (range 6.5-17) and 6 years (range 0.5-12.7) after renal transplantation (RTPL). IP was analyzed with the Wechsler Intelligence Scale for Children-III (WISC-III) in 25 patients and by the Kaufman Assessment Battery for Children in two patients. MP was evaluated by the Zurich Neuromotor Assessment. Median full- scale intelligent quotient (FSIQ) was 97 (range 49-133). Twenty-one patients had an FSIQ >or= 85 (i.e. >or= mean-1 standard deviation). The five patients with neurological comorbidity had a median FSIQ of 81 (range 49-101). Verbal IQ (VIQ) (median 104; range 50-146) was significantly (p < 0.01) higher than performance IQ (PIQ) (median 88; range 48-117). The PIQ was significantly lower compared with controls (p < 0.007), and patients scored significantly lower compared with controls in five of 11 subtests of the Wechsler Scale. All MP tasks were significantly (p < 0.01) lower than in controls, and also in children without neurological comorbidity. Socioeconomic status was significantly correlated with FSIQ (p = 0.03). IP after RTPL was within the normal range for the majority of children. PIQ was lower compared with VIQ, and MP was significantly affected in all children after RTPL.
authors.affiliation: Nephrology Unit, University Children's Hospital, Steinwiesstrasse 75, Zurich, Switzerland.
authors.forename: Jutta
authors.initials: J
authors.lastname: Falger
authors.forename: Bea
authors.initials: B
authors.lastname: Latal
authors.forename: Markus A
authors.initials: MA
authors.lastname: Landolt
authors.forename: Phaedra
authors.initials: P
authors.lastname: Lehmann
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Neuhaus
authors.forename: Guido F
authors.initials: GF
authors.lastname: Laube
mesh_terms: D000293:Adolescent; D002648:Child; D002657:Child Development; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007360:Intelligence; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000503:physiopathology* / Q000601:surgery*; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012307:Risk Factors; D012959:Socioeconomic Factors; D016896:Treatment Outcome; D014888:Wechsler Scales