title: Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features.
abstract: Post mortem brain studies indicate that alterations in serotonergic and catecholaminergic systems might be associated with Alzheimer's disease (AD). The aim of the study was to determine serotonin (5-HT) levels and monoamine oxidase type B (MAO-B) activity in platelets of psychotic and non-psychotic patients with AD, established according to the NINCDS-ADRDA and DSM-IV-TR criteria. Cognitive impairment and psychotic features were evaluated using Mini Mental Status Examination and Neuropsychiatric Inventory. Platelet 5-HT concentration and MAO-B activity were determined spectrofluorimetrically in 116 (51 male, 65 female) healthy subjects and 70 psychotic (10 male, 60 female) and 151 non-psychotic (32 male, 119 female) patients. Psychotic and non-psychotic female and psychotic male patients had significantly lower platelet 5-HT concentration than corresponding sex matched control subjects. Platelet MAO-B activity was significantly increased in both male and female non-psychotic patients compared to the sex matched controls. Non-psychotic female patients had significantly higher platelet MAO-B activity than psychotic female patients. Our data suggest that platelet MAO-B activity, but not platelet 5-HT concentration, could differentiate between psychotic and non-psychotic subtypes of AD.
authors.affiliation: Department of Psychiatry, Psychiatric Hospital Vrapce, Zagreb, Croatia.
authors.forename: Ninoslav
authors.initials: N
authors.lastname: Mimica
authors.forename: Dorotea
authors.initials: D
authors.lastname: Mück-Seler
authors.forename: Nela
authors.initials: N
authors.lastname: Pivac
authors.forename: Maja
authors.initials: M
authors.lastname: Mustapić
authors.forename: Martina
authors.initials: M
authors.lastname: Dezeljin
authors.forename: Tamara
authors.initials: T
authors.lastname: Stipcević
authors.forename: Paola
authors.initials: P
authors.lastname: Presecki
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Radonić
authors.forename: Vera
authors.initials: V
authors.lastname: Folnegović-Smalc
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000145:classification; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D011618:Psychotic Disorders / Q000097:blood / Q000145:classification; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin; D008995:Monoamine Oxidase