title: The common D302H variant of CASP8 is associated with risk of glioma.
abstract: Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Lara
authors.initials: L
authors.lastname: Bethke
authors.forename: Kate
authors.initials: K
authors.lastname: Sullivan
authors.forename: Emily
authors.initials: E
authors.lastname: Webb
authors.forename: Anne
authors.initials: A
authors.lastname: Murray
authors.forename: Minouk
authors.initials: M
authors.lastname: Schoemaker
authors.forename: Anssi
authors.initials: A
authors.lastname: Auvinen
authors.forename: Anne
authors.initials: A
authors.lastname: Kiuru
authors.forename: Tiina
authors.initials: T
authors.lastname: Salminen
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
authors.forename: Helle Collatz
authors.initials: HC
authors.lastname: Christensen
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.forename: Patricia
authors.initials: P
authors.lastname: McKinney
authors.forename: Sarah
authors.initials: S
authors.lastname: Hepworth
authors.forename: Polyxeni
authors.initials: P
authors.lastname: Dimitropoulou
authors.forename: Artitaya
authors.initials: A
authors.lastname: Lophatananon
authors.forename: Maria
authors.initials: M
authors.lastname: Feychting
authors.forename: Stefan
authors.initials: S
authors.lastname: Lönn
authors.forename: Anders
authors.initials: A
authors.lastname: Ahlbom
authors.forename: Beatrice
authors.initials: B
authors.lastname: Malmer
authors.forename: Roger
authors.initials: R
authors.lastname: Henriksson
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D005260:Female; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D053181:Caspase 8