title: Colorectal carcinoma with potentially resectable metastases: factors associated with the failure of curative schedule.
abstract: BACKGROUND
  The management of patients with colorectal cancer (CRC) and synchronous liver metastases (SLM) depends on the primitive tumor, resectability of the metastatic disseminations and the patient's comorbid condition(s). Considering all patients with potentially resectable primary CRC and SLM, curative resection (R0) will be possible in some patients, although in others surgery will never be performed. The purpose of our study was to identify factors of failure of the curative schedule in these patients.
  
  
  METHODS
  We reviewed the data of patients with CRC and SLM between January 2002 and March 2007. Two groups were defined: group R0 when complete metastatic and primary tumor resection was finally achieved after one and more surgical stages and group R2 when curative resection was not possible at the end of the schedule. Clinical, pathologic and outcome data were retrospectively analyzed as well as preoperative management of SLM (chemotherapy, radiofrequency, portal vein embolization).
  
  
  RESULTS
  Forty-five patients were included. Curative resection (group R0) was performed in 31 patients (69%) with 48% undergoing major hepatic resection. Mortality of hepatic resection was 0% although it was 9% for primitive tumor. Portal vein embolization was performed preoperatively in eight patients and radiofrequency ablation in 13. Median follow-up was 21 months. Overall survival was 86% at one year and 39% at three years. Survival in group 1 was 97 and 57% at one and three years respectively. Disease-free survival was 87 and 40% at one and three years. Tumor recurrence was noted in 61% of resected patients. At multivariate analysis, number of hepatic metastases superior than three and complicated initial presentation of primitive tumor were found to be significant and predictors of failure of hepatic resection.
  
  
  CONCLUSIONS
  Aggressive management with curative resection of SLM may enable long-term survival. More than three SLM and complicated initial presentation of primitive tumor are factors predictive of failure of the curative schedule.
authors.affiliation: Service de Chirurgie Digestive et Viscérale, CHU d'Amiens-Nord, Place Victor-Pauchet, 80054 Amiens Cedex 1, France.
authors.forename: D
authors.initials: D
authors.lastname: Fuks
authors.forename: M-C
authors.initials: MC
authors.lastname: Cook
authors.forename: O
authors.initials: O
authors.lastname: Bréhant
authors.forename: A
authors.initials: A
authors.lastname: Henegar
authors.forename: F
authors.initials: F
authors.lastname: Dumont
authors.forename: D
authors.initials: D
authors.lastname: Chatelain
authors.forename: T
authors.initials: T
authors.lastname: Yzet
authors.forename: G
authors.initials: G
authors.lastname: Mulieri
authors.forename: J-P
authors.initials: JP
authors.lastname: Joly
authors.forename: E
authors.initials: E
authors.lastname: Nguyen-Khac
authors.forename: J-L
authors.initials: JL
authors.lastname: Dupas
authors.forename: F
authors.initials: F
authors.lastname: Mauvais
authors.forename: P
authors.initials: P
authors.lastname: Verhaeghe
authors.forename: J-M
authors.initials: JM
authors.lastname: Regimbeau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D012307:Risk Factors; D017211:Treatment Failure