title: Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats.
abstract: The effect of Eriobotrya japonica seed extract (ESE) prepared with 70% ethanol on gastric mucosal injury was investigated. Six experimental models with different action mechanisms were used for the evaluation. Three concentrations of ESE were prepared for each model. ESE administration was initiated 14 days before induction of gastric mucosal injury, and its effect was investigated. ESE inhibited formation of gastric mucosal injury.
authors.affiliation: Japan Science and Technology Agency, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan. jm-yokotaj@kochi-u.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Yokota
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takuma
authors.forename: Atsuhide
authors.initials: A
authors.lastname: Hamada
authors.forename: Masahide
authors.initials: M
authors.lastname: Onogawa
authors.forename: Saburo
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kusunose
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Miyamura
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kyotani
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishioka
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D031983:Eriobotrya / Q000737:chemistry; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005765:Gastrointestinal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009093:Mucus / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D005765:Gastrointestinal Agents; D010936:Plant Extracts; D020011:Protective Agents