title: Peak oxygen consumption and the minute ventilation/carbon dioxide production relation slope in morbidly obese men and women: influence of subject effort and body mass index.
abstract: The authors evaluated the minute ventilation/carbon dioxide production relation (VE/VCO2 slope) as a complementary measure to peak oxygen consumption (peak VO2) in 76 patients (mean +/- SD age = 44.3+/-10.8 years, 69.7% female) with morbid obesity (mean +/- SD body mass index [BMI] = 49.4+/-7.0 kg/m(2)), as it is not limited by effort. Nearly one-half (43%) of the patients achieved a peak respiratory exchange ratio <1.10. Mean peak VO2 and VE/VCO2 slope were 17.0+/-3.7 mL/kg/min and 27.8+/-4.0, respectively. Peak VO2 correlated with BMI (r=-0.45, P<.0001), while VE/VCO2 slope did not (r=-0.04, P=.73). There was a linear trend for declining mean peak VO2 (P=.001) but not for VE /VCO2 slope (P=.59) with increasing BMI quintiles. The VE/VCO2 slope is an effort-independent measure that is also independent of BMI and may serve as an adjunctive cardiorespiratory variable when evaluating morbidly obese men and women.
authors.affiliation: From the Department of Medicine, Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA. adejong@beaumont.edu
authors.forename: Adam T
authors.initials: AT
authors.lastname: deJong
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gallagher
authors.forename: Keisha R
authors.initials: KR
authors.lastname: Sandberg
authors.forename: Martin A
authors.initials: MA
authors.lastname: Lillystone
authors.forename: Thomas
authors.initials: T
authors.lastname: Spring
authors.forename: Barry A
authors.initials: BA
authors.lastname: Franklin
authors.forename: Peter A
authors.initials: PA
authors.lastname: McCullough
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002245:Carbon Dioxide / Q000378:metabolism*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism*; D010101:Oxygen Consumption; D011446:Prospective Studies; D012123:Pulmonary Ventilation
chemical_list: D002245:Carbon Dioxide