title: Ascending aortic aneurysms in unicommissural aortic valve disease.
abstract: BACKGROUND
  Aneurysms of the ascending aorta occur as result of intrinsic changes in the aortic wall and have been well documented in patients with bicuspid aortic valve (BAV). In few reported clinical studies, documenting aneurysmal dilatation in unicommissural aortic valves (UAV); there have been no comments on the aortic wall pathology. This study presents the pathological findings of the ascending aorta in patients with UAV.
  
  
  METHODS
  The clinical data from 39 patients with concomitant excision of the UAV and aneurysmal aortic tissue were reviewed. In all cases, the gross features of the valve and aortic segments were noted and submitted for histology. The sections of the aorta were semi-quantitatively graded for the extent of medionecrosis, cystic medial change, fibrosis, and elastic tissue changes (fragmentation/ loss) in the media. The medial alterations were correlated with patient age, gender, and valvular dysfunction, and compared to aneurysmal disease in BAV and three-cuspid aortic valves (TAV) excised over a 3-year period.
  
  
  RESULTS
  Among 39 patients studied, a majority were males (92.3%), with a mean age at surgery of 39.92 years. Only three patients (7.69%) were above the age of 50 years. Eighteen patients (46.1%) had aortic stenosis with regurgitation. Ascending aorta diameters ranged from 4 to 5.5 cm. The overall pattern of medial changes was nearly the same in all cases of UAV, irrespective of age and nature of valvular dysfunction. Most cases showed mild histological changes, with medionecrosis and fibrosis being the more common and consistent features. However, varying grades of change affected different portions of the media and/or the aortic wall in the same patient. The changes in UAV aortae were comparable to the changes seen in the TAV and BAV, but these differed with the age of onset.
  
  
  CONCLUSIONS
  This study demonstrates the presence of medial changes in the ascending aortic tissue in all patients of UAV with aneurysms. These changes, while mild to moderate in degree, likely have a similar pathogenetic mechanism as those seen in BAV disease. The significant difference in age, at the time of surgery, suggests a more rapid progression of the aortic changes.
authors.affiliation: Department of Pathology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada. jagdish.butany@uhn.on.ca
authors.forename: Jagdish
authors.initials: J
authors.lastname: Butany
authors.forename: Pradeep
authors.initials: P
authors.lastname: Vaideeswar
authors.forename: Vidya
authors.initials: V
authors.lastname: Dixit
authors.forename: Vidyadhar
authors.initials: V
authors.lastname: Lad
authors.forename: Annette
authors.initials: A
authors.lastname: Vegas
authors.forename: Tirone E
authors.initials: TE
authors.lastname: David
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000473:pathology*; D001014:Aortic Aneurysm / Q000473:pathology*; D001021:Aortic Valve / Q000002:abnormalities* / Q000473:pathology*; D001022:Aortic Valve Insufficiency / Q000150:complications; D001024:Aortic Valve Stenosis / Q000150:complications / Q000473:pathology*; D050197:Atherosclerosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017540:Tunica Media / Q000473:pathology; D055815:Young Adult