Preparation and phytotoxicity of novel kaurane diterpene amides with potential use as herbicides.
Novel kaurane ditepene monoamides were synthesized in good yields directly from kaurenoic ( 1) and grandiflorenic ( 2) acids and unprotected symmetrical diamines, using a modified protocol for monoacylation. Amides from 1 and 2 and monoamines were also obtained and tested against seed germination and growth of radicle and shoot of Lactuca sativa (lettuce), at 10 (-3), 10 (-5), and 10 (-7) M. Amides from symmetrical diamines showed significant inhibitory activity at higher concentrations.
Boaventura
Maria Amélia Diamantino
MA
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil. dianadb@netuno.lcc.ufmg.br
Pereira
Rondinelle Gomes
RG
de Oliveira Freitas
Luiza B
LB
Dos Reis
Leandro Alves
LA
da Silva Vieira
Henriete
H
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry; D045786:Diterpenes, Kaurane / Q000138:chemical synthesis* / Q000494:pharmacology*; D018525:Germination / Q000187:drug effects; D006540:Herbicides / Q000494:pharmacology*; D018545:Lactuca / Q000187:drug effects / Q000254:growth & development; D018520:Plant Shoots / Q000187:drug effects / Q000254:growth & development; D010944:Plants / Q000187:drug effects*
D000577:Amides; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D006540:Herbicides; C014576:grandiflorenic acid; C051436:kaurenoic acid