Good's syndrome in a patient with cytomegalovirus retinitis.
Thymoma-related adult-onset immunodeficiency or Good's syndrome is an uncommon condition. This case, of a 50-year-old woman who was human immunodeficiency virus-negative and developed herpes zoster and severe cytomegalovirus retinitis 6 months after removal of a thymoma, is the first to be reported in Hong Kong. Immunological investigations revealed no B cells, hypogammaglobulinaemia, a low CD4 count, and a low CD4/CD8 ratio. We recommend that immunological investigations, including T-cell subsets, B cells, and quantitative immunoglobulins, should be part of the routine diagnostic evaluation of patients with thymoma and infections.
Yong
David S P
DS
Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong.
Tsang
M K
MK
Chan
Eric Y T
EY
Tse
Doris M W
DM
D000361:Agammaglobulinemia / Q000175:diagnosis / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006562:Herpes Zoster / Q000175:diagnosis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000276:immunology; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000276:immunology; D013934:Thymectomy; D013945:Thymoma / Q000276:immunology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000276:immunology / Q000601:surgery*