title: Lipomatous metaplasia after severe and chronic cutaneous inflammation.
abstract: A 69-year-old woman with a history of acute generalized exanthematic pustulosis (AGEP) caused by metamizole is described. Furthermore, she had suffered from an untreated psoriasis since the age of 20. After an adequate therapy of both psoriasis and AGEP, yellow-brownish, static, coalescing, lucent nodules on the thighs and upper arms became apparent. Histology of skin biopsies revealed a prominent band of mature adipocytes in the dermis. We diagnosed a lipomatous metaplasia of the dermis and hypothesize that this metaplasia occurred as a consequence of the severe and chronic inflammation of the skin.
authors.affiliation: Department of Dermatology and Allergy, Technical University, Munich, Germany.
authors.forename: Kilian
authors.initials: K
authors.lastname: Eyerich
authors.forename: Claudia
authors.initials: C
authors.lastname: Traidl-Hoffmann
authors.forename: Annette
authors.initials: A
authors.lastname: Albert
authors.forename: Regina
authors.initials: R
authors.lastname: Kerzl
authors.forename: Stephanie
authors.initials: S
authors.lastname: Rombold
authors.forename: Ulf
authors.initials: U
authors.lastname: Darsow
authors.forename: Bernadette
authors.initials: B
authors.lastname: Eberlein
authors.forename: Thilo
authors.initials: T
authors.lastname: Jakob
authors.forename: Johannes
authors.initials: J
authors.lastname: Ring
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Hein
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000368:Aged; D020405:Dermis / Q000473:pathology*; D004008:Diclofenac / Q000009:adverse effects; D004177:Dipyrone / Q000009:adverse effects; D003875:Drug Eruptions / Q000150:complications*; D005121:Extremities / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D008068:Lipomatosis / Q000209:etiology* / Q000473:pathology; D008679:Metaplasia / Q000209:etiology* / Q000473:pathology; D011565:Psoriasis / Q000150:complications*; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000150:complications*
chemical_list: D004008:Diclofenac; D004177:Dipyrone