title: The presence of DRB1*01 allele in multiple myeloma patients is associated with an indolent disease.
abstract: The human leukocyte antigen (HLA) system could play an essential role in multiple myeloma (MM) disease control. This report describes the results comparing HLA-DRB1 phenotypic frequencies in 181 MM patients (53 smoldering/indolent MM and 128 symptomatic MM patients) and healthy individuals. Higher DRB1*01 phenotypic frequencies were found in the smoldering patients compared with symptomatic MM patients (38% vs 14%, P = 0.001) and with the healthy individuals (38% vs 22%, P = 0.01). Additionally, higher DRB1*07 phenotypic frequencies were found in symptomatic MM compared with control population (38% vs 28%, P = 0.01). The present data suggest that HLA-DRB1*01 individuals may have a better ability to efficiently present myeloma-related antigens to immunocompetent cells, which could favor a better immune response against the tumor. This would translate into a more appropriate disease control associated with more indolent disease and prolonged survival.
authors.affiliation: Departamento de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Alcoceba
authors.forename: L
authors.initials: L
authors.lastname: Marín
authors.forename: A
authors.initials: A
authors.lastname: Balanzategui
authors.forename: M E
authors.initials: ME
authors.lastname: Sarasquete
authors.forename: P
authors.initials: P
authors.lastname: Martín-Jiménez
authors.forename: M C
authors.initials: MC
authors.lastname: Chillón
authors.forename: R
authors.initials: R
authors.lastname: Corral
authors.forename: E
authors.initials: E
authors.lastname: Pérez-Persona
authors.forename: F J
authors.initials: FJ
authors.lastname: Fernández-Calvo
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Bladé
authors.forename: J J
authors.initials: JJ
authors.lastname: Lahuerta
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: J F
authors.initials: JF
authors.lastname: San Miguel
authors.forename: R
authors.initials: R
authors.lastname: García-Sanz
mesh_terms: D017951:Antigen Presentation / Q000235:genetics / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D010641:Phenotype
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C497841:HLA-DRB1*01 antigen