[Coma criterion and classification standard of mild and moderate traumatic brain injury in rats].
OBJECTIVE
To set up a classification standard of mild and moderate traumatic brain injury, for the purpose of reliable data comparison derived from different laboratories.


METHODS
Traumatic brain injury (TBI) in rats was prepared by using a metallic pendulum-striker device. After injury, five variable parameters including the time of apnea and the areflexia, time of corneal reflex, external auditory canal stung reaction, body-righting reflex and needling reaction were determined and scored by using rat coma criterion. These data were judged and classified into mild and moderate head injury by brain patho-anatomy changes. Then the data were used to set up a multivariate discriminate equation.


RESULTS
The distinguished probability of mild and moderate TBI according to actual direct measured value and the criterion were 88.9% and 91.9%, respectively.


CONCLUSIONS
This method is able to classify mild and moderate TBI in rats.
Yu
Jian-Yun
JY
Department of Forensic Medicine, Kunming Medical College, Kunming 650031, China. jianyunyu@sina.com
Li
Jun-Xiang
JX
Guo
Ze-Yun'
ZY
Zhao
Xiao-Lin
XL
Zhao
Xu-Dong
XD
D000818:Animals; D001930:Brain Injuries / Q000145:classification* / Q000150:complications* / Q000473:pathology; D003128:Coma / Q000145:classification* / Q000209:etiology*; D005554:Forensic Medicine; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley