Prognostic implications of the immunophenotype in biphenotypic acute leukemia.
The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.
Lee
Je-Hwan
JH
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Min
Yoo Hong
YH
Chung
Chul Won
CW
Kim
Byoung Kook
BK
Yoon
Hwi-Joong
HJ
Jo
Deog-Yeon
DY
Shin
Ho-Jin
HJ
Bang
Soo-Mee
SM
Won
Jong-Ho
JH
Zang
Dae Young
DY
Kim
Hyeoung Joon
HJ
Chi
Hyun-Sook
HS
Lee
Kyoo-Hyung
KH
Cheong
June-Won
JW
Kim
Jin Seok
JS
Kim
Sun Hee
SH
Park
Seonyang
S
Park
Su Yon
SY
Chung
Joo Seop
JS
Lee
Jae Hoon
JH
Park
Chan-Jeoung
CJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007723:Korea; D015456:Leukemia, Biphenotypic, Acute / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis; D013601:T-Lymphocytes
D015415:Biomarkers