Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking.
Ma
Dik-Lung
DL
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Lai
Tat-Shing
TS
Chan
Fung-Yi
FY
Chung
Wai-Hong
WH
Abagyan
R
R
Leung
Yun-Chung
YC
Wong
Kwok-Yin
KY
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D001667:Binding, Competitive; D002942:Circular Dichroism; D003198:Computer Simulation; D004247:DNA / Q000187:drug effects; D019992:Databases as Topic; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes / Q000187:drug effects*; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C530381:1H-pyrazole-3-carboxy-4-methyl-5-phenyl-(1H-indol-3-ylmethylene)hydrazide; D000970:Antineoplastic Agents; D006835:Hydrazones; D008024:Ligands; D011720:Pyrazoles; D004247:DNA