Thoracic aortic aneurysm syndrome in children.
In contrast with adults, thoracic aortic aneurysms in children are usually associated with connective tissue defect syndromes. As such, there are phenotypic clues to identify patients at risk. Marfan syndrome, Loeys-Dietz syndrome, and bicuspid aortic valve syndrome account for the majority of these aneurysms. Indications for surgery as well as surgical options differ according to diagnosis and are reviewed herein.
Zanotti
Giorgio
G
Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Vricella
Luca
L
Cameron
Duke
D
D017545:Aortic Aneurysm, Thoracic / Q000209:etiology / Q000235:genetics* / Q000601:surgery*; D001021:Aortic Valve / Q000002:abnormalities; D019917:Blood Vessel Prosthesis Implantation; D002648:Child; D004535:Ehlers-Danlos Syndrome / Q000150:complications / Q000601:surgery; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications / Q000601:surgery; D009154:Mutation; D010641:Phenotype; D013577:Syndrome; D016212:Transforming Growth Factor beta / Q000235:genetics*
D016212:Transforming Growth Factor beta