Effect of artichoke extract (Cynara scolymus L.) on palmitic-1-14C acid oxidation in rats.
Studies on the effect of the artichoke extract (AE) on oxidation of palmitic-1-14C acid administered intravenously to rats at a dose 25 and 50 mg/kg bw demonstrated marked enhancement of both 14CO2 expiration rate and 14CO2 recovery in the expired air. The extract suppressed accumulation of palmitic-1-14C acid in serum lipids and epididymal fat pad tissue as well. The effects of the extract on 14CO2 expiration rate, 14CO2 recovery, as well as accumulation of palmitic-1-14C acid were dose dependent. Total14CO2 recovery in expired air during 60 min was elevated by 17.3% (p < 0.05) and 52.1% (p < 0.001) in rats administered the extract at a dose of 25 and 50 mg/kg, respectively. The rats supplemented with the AE at a dose of 25 and 50 mg/kg bw were characterized by 10.0% (not significant) and 19% (p < 0.05) decrease in( 14)C radioactivity of serum lipids as well as reduction of epididymal fat tissue 14C radioactivity by 8.7 and 17.5% (p < 0.05), respectively, in comparison with the control rats. Thus, the results demonstrate that the AE possess stimulatory properties with respect to oxidation of palmitic acid administered to rats, and provide new information on the mechanism of antilipemic activity of the extract associated with activation of lipid oxidation in the organism.
Juzyszyn
Zygmunt
Z
Department of Drug Toxicology and Pharmacoeconomics, Pomeranian Medical University, Szczecin, Poland. zjuzyszyn@wp.pl
Czerny
Boguslaw
B
Pawlik
Andrzej
A
Drozdzik
Marek
M
D000818:Animals; D002250:Carbon Radioisotopes; D031943:Cynara scolymus; D007553:Isotope Labeling / Q000379:methods; D007700:Kinetics; D008297:Male; D010084:Oxidation-Reduction; D019308:Palmitic Acid / Q000097:blood / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002250:Carbon Radioisotopes; D010936:Plant Extracts; D019308:Palmitic Acid