[The effect of pineal peptide preparations on proliferative activity in organotypic culture of the preoptic hypothalamus area].
In investigations carried out with organotypic culture of mediobasal preoptic area (MPA) of hypothalamus it was established that pineal peptide preparations epitalon (2 ng/ml) and epithalamin (100 ng/ml) stimulate the development of proliferative activity of explants in 3 month and 24 months female rats. It has been shown that epithalamin is more effective in young rats in comparison with old animals, but epitalon as well as epithalamin have almost the same less pronounced inducing effect on growth zone in MPA explants from young and old animals. This effect is tissue specific and could be dependent on inhibition of apoptosis.
Miliutina
Iu P
IuP
Kozina
L S
LS
Arutiunian
A V
AV
Chalisova
N I
NI
Lesniak
V V
VV
Morozova
P Iu
PIu
D000375:Aging / Q000473:pathology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D007150:Immunohistochemistry; D009842:Oligopeptides / Q000302:isolation & purification / Q000494:pharmacology*; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D010870:Pineal Gland / Q000737:chemistry*; D011301:Preoptic Area / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D009842:Oligopeptides; D010455:Peptides; D016159:Tumor Suppressor Protein p53; C027437:epithalamin; C421253:alanyl-glutamyl-aspartyl-glycine