title: Central cardiovascular actions of angiotensin II in trout.
abstract: In mammals, a large body of evidence supports the existence of a brain renin-angiotensin system (RAS) acting independently or synergistically with the endocrine RAS to maintain diverse physiological functions, notably cardiovascular homeostasis. The RAS is of ancient origin and although most components of the RAS are present within the brain of teleost fishes, little is known regarding the central physiological actions of the RAS in these vertebrates. The present review encompasses the most relevant functional data for a role of the brain RAS in cardiovascular regulations in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. This paper mainly focuses on the central effect of angiotensin II (ANG II) on heart rate, blood pressure, heart rate variability and cardiac baroreflex, after intracerebroventricular injection or local microinjection of the peptide within the dorsal vagal motor nucleus. The probable implications of the parasympathetic nervous system in ANG II-evoked changes in the cardiac responses are also discussed.
authors.affiliation: Laboratoire de Traitement de l'Information Médicale (LaTIM, INSERM U650), Université de Bretagne Occidentale, 22 avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France. jean-claude.lemevel@univ-brest.fr
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Le Mével
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lancien
authors.forename: Nagi
authors.initials: N
authors.lastname: Mimassi
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects; D014337:Trout / Q000502:physiology*
chemical_list: D000804:Angiotensin II