Lower gastrointestinal functions.
The human colon serves to absorb water and electrolytes, store intraluminal contents until elimination is socially convenient, and salvage nutrients by bacterial metabolism of carbohydrates that have not been absorbed in the small intestine. The anorectum is responsible for fecal continence and defecation. This article is a broad perspective of the current status and a personal perspective of future challenges in understanding lower gastrointestinal functions in health and disease in humans.
Bharucha
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Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.), Mayo Clinic, Rochester, MN 55905, USA. bharucha.adil@mayo.edu
D000818:Animals; D003106:Colon / Q000378:metabolism / Q000382:microbiology / Q000502:physiology; D005767:Gastrointestinal Diseases / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D041741:Lower Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology / Q000502:physiology*; D012007:Rectum / Q000378:metabolism / Q000382:microbiology / Q000502:physiology