Pushing the envelope: developmental regulation by the nuclear lamina.
A surprising realization in recent years was that proteins of the nuclear lamina directly regulate gene expression and cell differentiation. Presented here are examples that highlight the diverse roles these proteins can inhabit. Accompanying the primer is a discussion of current topics in the field with nuclear lamina experts Colin Stewart, Ph.D., and Yosef Gruenbaum, Ph.D.
Kiefer
Julie C
JC
Department of Neurobiology and Anatomy, 401 MREB, University of Utah, Salt Lake City, Utah 84132, USA. jkiefer@neuro.utah.edu
D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D034882:Lamins / Q000378:metabolism*; D009154:Mutation; D034881:Nuclear Lamina / Q000737:chemistry / Q000502:physiology; D010641:Phenotype
D034882:Lamins