Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery.
Cell-penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully used for intracellular delivery of a broad variety of cargos including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles). Here, we will consider the main results in this area, with a special emphasis on TATp-mediated delivery of liposomes and DNA. We will also address the development of "smart" stimuli-sensitive nanocarriers, where cell-penetrating function can be activated by the decreased pH only inside the biological target minimizing thus the interaction of drug-loaded nanocarriers with nontarget cells.
Torchilin
Vladimir P
VP
Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115. v.torchilin@neu.edu
D000818:Animals; D004247:DNA / Q000008:administration & dosage; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism*; D018014:Gene Transfer Techniques; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D008081:Liposomes; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000235:genetics; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000008:administration & dosage / Q000235:genetics
D004337:Drug Carriers; D008081:Liposomes; D010455:Peptides; D054322:tat Gene Products, Human Immunodeficiency Virus; D004247:DNA