Dihydroxystyrene metabolites from an association of the sponges Poecillastra wondoensis and Jaspis sp.
Five new dihydroxystyrene metabolites and six known compounds of the same structural class were isolated from an association of the sponges Poecillatra wondoensis and Jaspis sp., collected from Keomun Island, Korea. The structures of novel compounds were determined to be the sodium or N, N-dimethyl guanidinium salts of a dihydroxystyrene dimer (5) and two trimers (6, 7). Two dimers (10, 11) containing imidazole moieties were also identified on the basis of the results of combined spectroscopic analyses. Several compounds exhibited weak to moderate inhibitory effects against isocitrate lyase and sortase A enzymes derived from microorganisms.
Chang
Yong Ha
YH
College of Pharmacy, Seoul National University, Gwanak-Gu, Seoul, Korea.
Shin
Daehyun
D
Na
Zeyei
Z
Lee
Hyi-Seung
HS
Kim
Dae-Duk
DD
Oh
Ki-Bong
KB
Shin
Jongheon
J
D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D003546:Cysteine Endopeptidases; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D007723:Korea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D013343:Styrenes; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; D007522:Isocitrate Lyase