Misoprostol and first trimester pregnancy termination.
OBJECTIVE
To investigate the efficacy of vaginal administration of 800 microg misoprostol as a single dose without performing post expulsion systematic curettage in first trimester pregnancy termination.


METHODS
113 women, aged 16-44, who requested first trimester pregnancy termination, received 800 microg of vaginal misoprostol. All examined women were divided into two groups depending on gestation age. The first group included of 67 women with up to nine weeks and the second of 46 with up to 12 weeks of pregnancy.


RESULTS
Abortion occurred within 24 hours and was completed in 74.3% of the cases. The mean induction-abortion interval was 5.9 +/- 1.7 hours (median 5.5 hours). Side-effects were experienced by 24 women (21.2%). There was no significant difference between groups in the success rate, induction-abortion interval, number of previous deliveries and side-effects.


CONCLUSIONS
Misoprostol is an effective agent for first trimester medical termination.
Grapsas
X
X
Department of Obstetrics and Gynecology, Democritus University of Thrace, General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Liberis
V
V
Vassaras
G
G
Tsikouras
P
P
Vlachos
G
G
Galazios
G
G
D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects / Q000819:agonists*; D000032:Abortion, Therapeutic / Q000009:adverse effects / Q000379:methods*; D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D016896:Treatment Outcome
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol