Health-related quality of life after bladder preservation therapy for muscle invasive bladder cancer.
OBJECTIVE
To assess health-related quality of life (QOL) of bladder cancer patients following bladder preservation therapy (BPT).


METHODS
Eighty patients with muscle-invasive bladder cancer had been treated between January 1992 and July 2005 at our institutions with BPT consisting of transurethral resection, intra-arterial chemotherapy and radiotherapy. Among them, 48 were alive and free from recurrence at the time of survey and were asked to participate. A total of 168 patients who had been treated for superficial bladder cancer in the same period were used as a control group. Three questionnaires, namely the International Prostate Symptom Score (IPSS), the SF-36, and the Expanded Prostate Cancer Index Composite (EPIC) were used.


RESULTS
Thirty-three patients in the BPT group (68.8%) and 128 patients in the control group (76.2%) answered the QOL survey. There was no significant difference in age, gender and other clinical factors among these two groups. No significant difference was found between the groups according to IPSS. The QOL score of BPT was lower than that of the control group in the SF-36, but there was no significant difference without body pain (P = 0.047). There was a tendency toward a diminished physical functioning (P = 0.053) and role-physical (P = 0.064) in BPT. The EPIC scores for urinary function, especially storage and voiding symptoms, and bowel function were significantly lower in the BPT group. At multivariable analysis, body pain and bowel function were associated with the type of treatment.


CONCLUSIONS
Although some of the QOL outcome parameters after BPT were found to be lower than the control group, these differences were not significant. Overall, patients retaining their bladder had an acceptable health related QOL.
Hashine
Katsuyoshi
K
Department of Urology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan. khashine@shikoku-cc.go.jp
Miura
Noriyoshi
N
Numata
Kousaku
K
Shirato
Akitomi
A
Sumiyoshi
Yoshiteru
Y
Kataoka
Masaaki
M
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011788:Quality of Life; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy*