Recent advances in the total synthesis of pharmaceutically relevant diterpenes.
A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
Busch
Torsten
T
Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, Hannover, D-30167, Germany.
Kirschning
Andreas
A
D001688:Biological Products / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis
D001688:Biological Products; D004224:Diterpenes; D004364:Pharmaceutical Preparations