MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis.
MSY2 is a highly conserved and abundant DNA/RNA-binding protein that functions as a global stabilizer/translational suppressor of mRNAs in male germ cells. The polypyrimidine tract binding protein, PTBP2, is an RNA-binding protein that splices nuclear transcripts and stabilizes specific mRNAs in the cytoplasm. The mechanisms whereby MSY2 selects and stabilizes a large group of male germ cell mRNAs and PTBP2 stabilizes specific mRNAs such as the phosphoglycerate kinase 2 mRNA in the testis and in transfected cells will be discussed.
Xu
Mingang
M
Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6080, USA.
Hecht
Norman B
NB
D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010735:Phosphoglycerate Kinase / Q000235:genetics; D038941:Polypyrimidine Tract-Binding Protein / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000502:physiology*; D013737:Testis / Q000378:metabolism*
D007527:Isoenzymes; D009419:Nerve Tissue Proteins; C504334:PTBP2 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C485481:YBX2 protein, human; D038941:Polypyrimidine Tract-Binding Protein; D010735:Phosphoglycerate Kinase; C104317:phosphoglycerate kinase, testis specific