Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.
The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an alpha,beta-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.
Buchanan
Malcolm S
MS
Eskitis Institute, Griffith University, Brisbane, Queensland 4111.
Carroll
Anthony R
AR
Fechner
Gregory A
GA
Boyle
Anthony
A
Simpson
Moana
M
Addepalli
Rama
R
Avery
Vicky M
VM
Hooper
John N A
JN
Cheung
Tony
T
Chen
Huwei
H
Quinn
Ronald J
RJ
D000818:Animals; D001315:Australia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C531268:aplysamine 6; C475724:bromotyrosine; D014443:Tyrosine; D011496:Protein Methyltransferases; C056501:protein-S-isoprenylcysteine O-methyltransferase