Phenolic constituents from the wood of Morus australis with cytotoxic activity.
A new methylated flavonol, 5,7,2',4'-tetrahydroxy-3-methoxyflavone (1), had been isolated from the methanol extract of the wood of Morus australis, along with nine known compounds, kuwanon C (2), morusin (3), morachalcone A (4), oxyresveratrol (5), 4'-(2-methyl-2-buten-4-yl)oxyresveratrol (6), moracins M (7) and C (8), alboctalol (9), and macrourin B (10). The structures of these compounds were determined based on spectral evidence, including UV, IR, NMR, and mass spectra. Cytotoxic properties of compounds 1-10 were evaluated against murine leukemia P-388 cells. The prenylated stilbene 6 and 2-arylbenzofuran 8, and morusin (3) were found to have strong cytotoxic effects with IC50 values of 6.9, 8.7, and 10.1 microM, respectively.
Ferlinahayati
Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia. euis@chem.itb.ac.id
Syah
Yana M
YM
Juliawaty
Lia D
LD
Achmad
Sjamsul A
SA
Hakim
Euis H
EH
Takayama
Hiromitsu
H
Said
Ikram M
IM
Latip
Jalifah
J
D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D031625:Morus / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D013053:Spectrophotometry; D014934:Wood
D047309:Flavones; D044948:Flavonols; D010636:Phenols; D010936:Plant Extracts