Lectins in the endoplasmic reticulum: the sweet side of protein quality control.
In a recent study in Nature Cell Biology, Christianson et al. provide intriguing insights into the mechanisms of mammalian protein quality control in the endoplasmic reticulum. Their findings open up new perspectives on the versatility and diversity of how protein quality control sorts out defective polypeptides to prevent damage to the cell.
Sommer
Thomas
T
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, D-13092 Berlin, Germany. tsommer@mdc-berlin.de
Gauss
Robert
R
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D037102:Lectins / Q000737:chemistry / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology
D006023:Glycoproteins; D037102:Lectins