Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy.
OBJECTIVE
To determine the effect of Prepacol, a combination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE).


METHODS
Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE.


RESULTS
Preparation with Prepacol accelerated small bowel transit time (262 +/- 55 min vs 287 +/- 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel.


CONCLUSIONS
The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution.
Franke
Andreas
A
Department of Medicine II (Gastroenterology, Hepatology and Infectious Diseases), University Hospital of Heidelberg at Mannheim, Mannheim D-68167, Germany. a.franke@gmx.net
Hummel
Frank
F
Knebel
Phillip
P
Antoni
Christoph
C
Bocker
Ulrich
U
Singer
Manfred V
MV
Lohr
Matthias
M
D000042:Absorption; D000328:Adult; D001726:Bisacodyl / Q000494:pharmacology*; D053704:Capsule Endoscopy / Q000379:methods*; D002400:Cathartics / Q000494:pharmacology; D003106:Colon / Q000473:pathology*; D005260:Female; D005762:Gastroenterology / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010710:Phosphates / Q000494:pharmacology*; D011446:Prospective Studies; D014867:Water / Q000737:chemistry
D002400:Cathartics; D010710:Phosphates; D014867:Water; D001726:Bisacodyl; C018279:sodium phosphate