title: Secondary prevention of arterial disease in very elderly people: results from a prospective registry (FRENA).
abstract: There is little information on the effectiveness of secondary prevention interventions in very elderly patients. In this article, the incidence of major cardiovascular events during a 12-month follow-up period in a series of consecutive patients with coronary, cerebrovascular, or peripheral artery disease is analyzed. As of October 2006, 1264 patients had been enrolled. Of these, 324 (26%) were >or=75 years of age. Their incidence rate of 22 events per 100 patient-years (95% CI, 17-28) was over 2-fold the 7.9 (95% CI, 6.2-10) found in those <75 years of age. Among them, only chronic heart failure and diabetes were independently associated with an increased risk for major events, whereas the use of angiotensin II antagonists was associated with a lower risk. Patients >or=75 years of age had an over 2-fold higher incidence of major cardiovascular events. The use of angiotensin II antagonists was associated with a lower risk.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: Luciano
authors.initials: L
authors.lastname: López-Jiménez
authors.forename: Miguel
authors.initials: M
authors.lastname: Camafort
authors.forename: Gregorio
authors.initials: G
authors.lastname: Tiberio
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Carmona
authors.forename: Carlos
authors.initials: C
authors.lastname: Guijarro
authors.forename: Francisco
authors.initials: F
authors.lastname: Martínez-Peñalver
authors.forename: Manuel
authors.initials: M
authors.lastname: Monreal
mesh_terms: D000367:Age Factors; D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000188:drug therapy*; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016017:Odds Ratio; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D055502:Secondary Prevention; D013030:Spain; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents