title: Sesame oil attenuates hepatic lipid peroxidation by inhibiting nitric oxide and superoxide anion generation in septic rats.
abstract: BACKGROUND
  Sepsis is a major cause of mortality in the intensive care unit. Oxidative stress plays an important role in the pathogenesis of organ failure during sepsis. Sesame oil decreases circulating oxygen free radicals in septic rats; however, its effect on hepatic oxidative status is unknown. The authors examined the effect of sesame oil on hepatic lipid peroxidation in septic rats.
  
  
  METHODS
  Hepatic injury was induced using cecal ligation and puncture (CLP). Rats were divided into 4 groups: sham, rats given a sham operation without CLP; SO, rats given sesame oil alone; CLP, rats given saline and then CLP; and CS, rats given sesame oil and then CLP. All rats were first given a 1-week daily oral supplement of sesame oil or saline (4 mL/kg/d) and then CLP or a sham operation. The authors assessed hepatic oxidative stress by determining hepatic lipid peroxidation, hydroxyl radical, superoxide anion, and nitric oxide levels 12 hours after CLP. They also assessed xanthine oxidase activity and nitric oxide synthase expression.
  
  
  RESULTS
  Hepatic lipid peroxidation (P < .0001), hydroxyl radical (P < .05), superoxide anion (P < .05), and nitrite (P < .05) levels were significantly lower in sesame oil-treated septic rats. Furthermore, sesame oil significantly reduced xanthine oxidase activity (P < .01) and inducible nitric oxide synthase expression (P < .005) in septic rats.
  
  
  CONCLUSIONS
  Sesame oil might attenuate hepatic lipid peroxidation by inhibiting superoxide anion and nitric oxide, at least partially, in experimental septic rats.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Se-Ping
authors.initials: SP
authors.lastname: Chien
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Li
authors.forename: Yin-Ching
authors.initials: YC
authors.lastname: Chuang
authors.forename: Yu-Chung
authors.initials: YC
authors.lastname: Chang
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002432:Cecum / Q000293:injuries / Q000473:pathology / Q000601:surgery; D017665:Hydroxyl Radical; D008026:Ligation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology / Q000293:injuries / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D018805:Sepsis / Q000517:prevention & control; D012715:Sesame Oil / Q000494:pharmacology*; D013047:Specific Pathogen-Free Organisms; D013481:Superoxides / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000187:drug effects / Q000378:metabolism
chemical_list: D009573:Nitrites; D017382:Reactive Oxygen Species; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D012715:Sesame Oil; D052247:Nitric Oxide Synthase Type II; D014969:Xanthine Oxidase