Calcium and calmodulin regulation of prolactin gene expression.
Prolactin gene transcription is critically dependent upon intracellular calcium and the calcium-binding protein calmodulin. The effects of calcium and calmodulin on the prolactin gene appear to involve defined regions of the 5'-flanking sequence, and interactions between nuclear proteins and this DNA may be related to mechanisms of transcriptional control by pituitary cell-type-specific trans-acting factors.
Davis
J R
JR
Department of Medicine, University of Manchester, Manchester, UK.