Poised polymerases: on your mark...get set...go!
Recent global analyses have determined that many Drosophila and human genes have engaged polymerase molecules trapped immediately downstream of promoters. These results strongly implicate RNA polymerase II elongation control as a major regulator of differentiation and development.
Price
David H
DH
Biochemistry Department, University of Iowa, Iowa City, IA 52240, USA. david-price@uiowa.edu
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D042925:Positive Transcriptional Elongation Factor B / Q000378:metabolism; D011401:Promoter Regions, Genetic; D014176:Protein Biosynthesis; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D042925:Positive Transcriptional Elongation Factor B; D012319:RNA Polymerase II