Possible therapeutic effect of direct haemoperfusion with a polymyxin B immobilized fibre column (PMX-DHP) on pulmonary oxygenation in acute exacerbations of interstitial pneumonia.
OBJECTIVE
Acute exacerbations of interstitial pneumonias (IP) can occasionally occur, and have an extremely poor prognosis. Recently, direct haemoperfusion with a polymyxin B immobilized fibre column (PMX-DHP) was shown to have a beneficial effect in acute exacerbations of IPF. However, little is known about the efficacy of PMX-DHP in acute exacerbations of other IP. This study investigated the effectiveness and safety of PMX-DHP in acute exacerbations of IP.


METHODS
The study subjects consisted of five patients with an acute exacerbation of IP, including three with IPF, one with idiopathic interstitial pneumonia (IIP) with atypical radiological findings of IPF, and one with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-related IP. The patients were treated with two courses of 3-12 h each of PMX-DHP, concurrently with corticosteroids alone or plus cyclophosphamide.


RESULTS
After two courses of PMX-DHP, the PaO(2)/fraction of inspired oxygen (FiO(2)) (P/F) ratio increased rapidly from an average of 93 to 260 mm Hg, and there was radiological improvement in all patients. However, one patient treated for 3 h each time eventually died of respiratory failure, and two patients treated for 6 h each time died from respiratory infections. The other two patients were treated for 12 h each time, and the therapeutic effects lasted longer, with both surviving longer than 48 days. No adverse effects were detected apart from thrombocytopaenia.


CONCLUSIONS
PMX-DHP therapy was safe and effective in improving oxygenation in acute exacerbations of IPs, either with corticosteroids alone or plus cyclophosphamide, and may be beneficial for the treatment of this condition.
Enomoto
Noriyuki
N
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Suda
Takafumi
T
Uto
Tomohiro
T
Kato
Masato
M
Kaida
Yusuke
Y
Ozawa
Yuichi
Y
Miyazaki
Hiroo
H
Kuroishi
Shigeki
S
Hashimoto
Dai
D
Naito
Tateaki
T
Fujisawa
Tomoyuki
T
Matsui
Takashi
T
Inui
Naoki
N
Nakamura
Yutaro
Y
Sato
June
J
Mizuguchi
Tomoaki
T
Kato
Akihiko
A
Chida
Kingo
K
D000210:Acute-Phase Reaction / Q000503:physiopathology; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D004359:Drug Therapy, Combination; D024243:HMGB1 Protein / Q000097:blood; D006464:Hemoperfusion / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D011112:Polymyxin B; D011446:Prospective Studies
D000305:Adrenal Cortex Hormones; D016207:Cytokines; D024243:HMGB1 Protein; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011112:Polymyxin B