Possible role of a taurine transporter in the deep-sea mussel Bathymodiolus septemdierum in adaptation to hydrothermal vents.
Various invertebrates inhabiting hydrothermal vents possess sulfur-oxidizing bacteria in their tissues; however, the mechanisms by which toxic sulfides are delivered to these endosymbionts remain unknown. Recently, detoxification of sulfides using thiotaurine, a sulfur-containing amino acid, has been suggested. In this study, we propose the involvement of a taurine transporter in sulfide detoxification in the deep-sea mussel Bathymodiolus septemdierum by demonstrating: (i) the abundance of its mRNA in the gill; (ii) its activity under a wide range of salinities; (iii) its low Michaelis constant value in taurine transportation; and (iv) its affinity for thiotaurine and the thiotaurine precursor, hypotaurine.
Inoue
Koji
K
Ocean Research Institute, The University of Tokyo, 1-15-1 Minamidai, Nakano, Tokyo 164-8639, Japan. inouek@ori.u-tokyo.ac.jp
Tsukuda
Kimihiko
K
Koito
Tomoko
T
Miyazaki
Yoshiko
Y
Hosoi
Masatomi
M
Kado
Ryusuke
R
Miyazaki
Nobuyuki
N
Toyohara
Haruhiko
H
D000064:Acclimatization; D000595:Amino Acid Sequence; D000818:Animals; D001001:Anura; D001692:Biological Transport; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D049879:Mytilidae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*; D014018:Tissue Distribution; D000099247:Taurine Transporters
D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D012333:RNA, Messenger; D013654:Taurine; D000099247:Taurine Transporters