Complement and renal transplantation: from donor to recipient.
Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome.
Damman
Jeffrey
J
Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands. j.damman@chir.umcg.nl
Schuurs
Theo A
TA
Ploeg
Rutger J
RJ
Seelen
Marc A
MA
D001926:Brain Death; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D014019:Tissue Donors
D003165:Complement System Proteins