Antioxidant and hepatoprotective activity of the methanol extract of Careya arborea bark in Ehrlich ascites carcinoma-bearing mice.
The methanol extract of Careya arborea bark (MECA) was tested for antioxidant and hepatoprotective activity in Ehrlich ascites carcinoma (EAC) tumor-bearing mice. Tumor control animals inoculated with EAC showed a significant alteration in the levels of antioxidant and hepatoprotective parameters. The extract treatment at 50, 100 and 200 mg/kg body weight doses given orally caused a significant reversal of these biochemical changes towards the normal in serum, liver and kidney when compared to tumor control animals indicating the potent antioxidant and hepatoprotective nature of the standardized extract.
Senthilkumar
Natesan
N
Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Rock lands, Ootacamund, Tamil Nadu, 643 001, India.
Badami
Shrishailappa
S
Dongre
Santoshkumar H
SH
Bhojraj
Suresh
S
D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D031381:Lecythidaceae / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005609:Free Radicals; D010936:Plant Extracts