[Persistent pulmonary hypertension of the newborn following ingestion of nonsteroidal anti-inflammatory drugs during pregnancy].
Nonsteroidal anti-inflammatory drugs induce the inhibition of prostaglandin synthesis, which can cause constriction of the fetal ductus arteriosus in the pregnancy. We report two cases of antenatal closure of ductus arteriosus with severe pulmonary hypertension following maternal ingestion of nonsteroidal anti-inflammatory drugs (niflumic acid and acetylsalicylic acid) in the last days before delivery. To our knowledge, this is only the second case in literature describing antenatal closure of ductus arteriosus after the administration of niflúmic acid. Prescription of nonsteroidal anti-inflammatory drugs must be avoided during pregnancy. Fetal echocardiography must be monitored in those women treated with nonsteroidal anti-inflammatory drugs.
Chacón Aguilar
R
R
Servicio de Neonatología. Departamento de Pediatría. Hospital General Universitario Gregorio Marañón. Madrid. España. rocio_chacon_aguilar@hotmail.com
Menéndez Hernando
C
C
Chimenti Camacho
P
P
Franco Sánchez
M L
ML
Sánchez Luna
M
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000175:diagnosis; D007231:Infant, Newborn; D008297:Male; D009544:Niflumic Acid / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009544:Niflumic Acid