Lignan glycosides from Neoalsomitra integrifoliola.
Five new lignan glycosides, (8R*,7' S*,8' R*)-5,5'-dimethoxy-7-oxolariciresinol 9'-O-beta-D-xylopyranoside (1), (7S,8R)-dihydrodehydrodiconiferyl alcohol 9-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside (2), (7S*,8R*,7' S*,8' R*)-4,4'-dimethoxyhuazhongilexin 9-O-beta-D-xylopyranoside (4), (7S*,8R*,7' S*,8' R*)-4,4'-dimethoxyhuazhongilexin 9-O-alpha-L-arabinopyranoside (5), and (7S*,8R*,7' S*,8' R*)-huazhongilexin 9-O-(2-feruloyl)-beta-D-xylopyranoside (6), together with four known compounds, (7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-beta-D-glucopyranoside (3), the 9-O-beta-D-xylopyranoside of icariol A(2) (7), huazhongilexin (8), and nudiposide (9), were isolated from the leaves of Neoalsomitra integrifoliola. Their structures were determined by spectroscopic analysis and chemical methods. Compounds 2, 3, 8, and 9 showed weak anti-inflammatory activities.
Su
Dongmin
D
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Tang
Wenzhao
W
Hu
Youcai
Y
Liu
Yunbao
Y
Yu
Shishan
S
Ma
Shuanggang
S
Qu
Jing
J
Yu
Dequan
D
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019662:Cucurbitaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans