Learning and memory in 5-HT(1A)-receptor mutant mice.
The serotonin 1A (5-HT(1A))-receptor is involved in a wide range of physiological functions, but has also been implicated in the pathophysiology of anxiety disorders and depression. Although the 5-HT(1A)-receptor is one of the best described receptor subtypes of the serotonergic system, its complex distribution pattern, pre- and postsynaptic localisation, and its impact on various neurotransmitters aggravate the attribution of 5-HT(1A)-agonistic effects to behavioural outcomes. The role of 5-HT(1A)-receptors for cognitive processes seems undisputed. However, the exact involvement of pre- and postsynaptic sites remains unexplained. Genetically modified animals are a complementary approach to pharmacological studies for further investigations of the role of the 5-HT(1A)-receptor. Next to 5-HT(1A)-receptor knockout mice, two transgenic mouse lines exist that either overexpress the 5-HT(1A)-receptor transiently or permanently. The latter mouse line stands out due to the fact that a distinct overexpression is primarily found in the outer cortical layers and hippocampus, both projection areas of serotonergic neurons. Here, we discuss the findings obtained from 5-HT(1A)-receptor knockout and overexpressing mice concerning their learning and memory abilities.
Bert
B
B
Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Koserstrasse 20, 14195 Berlin, Germany. bert.bettina@vetmed.fu-berlin.de
Fink
H
H
Rothe
J
J
Walstab
J
J
Bönisch
H
H
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A