title: Melengestrol acetate as a tool for inducing early ovulation in transitional mares.
abstract: The efficacy of melengestrol acetate (MGA) to shorten the vernal transition of mares by synchronising and accelerating the first ovulation of the year after 60 days of phototherapy was determined by ultrasonographic monitoring. Sixteen mares in late transition were fed two doses of MGA (150 mg/mare/day and 100 mg/mare/day, respectively) for 10 days. A luteolytic dose of prostaglandin was administered to each mare one day after the end of MGA treatment. The presence and duration of oestrus, follicular growth, uterine oedema and presence of ovulation were monitored by ultrasonography and the cervical tone was evaluated by rectal palpation. Ovulation was detected in 87.5% of the mares treated with 150 mg MGA/mare/day for 10 days, and in 62.5% of the mares receiving 100 mg MGA/mare/day for 10 days. This was statistically different (P = 0.03) from the untreated control mares having an ovulation rate of 20%. Mares that received 150 mg MGA/day for 10 days had a mean treatment to ovulation interval of 13.1 +/- 5.97 days after the end of treatment, while mares that received 100 mg MGA/day for 10 days had a mean of 25.6 +/- 10.50 days (P = 0.01) to ovulation. These results suggest that MGA can be used for synchronising and hastening the first ovulation of the year in mares.
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Veterinary Medicine and Zootechnics, National Autonomous University of Mexico (UNAM), Av. Universidad 3000, Coyoacán, Mexico City 04510, Mexico.
authors.forename: Consuelo
authors.initials: C
authors.lastname: López-Bayghen
authors.forename: Heidy
authors.initials: H
authors.lastname: Zozaya
authors.forename: Luis
authors.initials: L
authors.lastname: Ocampo
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Brumbaugh
authors.forename: Héctor
authors.initials: H
authors.lastname: Sumano
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006736:Horses; D008552:Melengestrol Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D010062:Ovulation Induction / Q000662:veterinary*
chemical_list: D005938:Glucocorticoids; D008552:Melengestrol Acetate