Two new cytotoxic pregnane glycosides from Cynanchum auriculatum.
Two new pregnane glycosides, kidjoranin 3- O- alpha-diginopyranosyl-(1-->4)- beta-cymaropyranoside (1) and kidjoranin 3-O-beta-digitoxopyranoside (2), together with one known compound caudatin 3 -O-beta-cymaropyranoside (3), were isolated from the roots of Cynanchum auriculatum. Their structures were established on the basis of NMR analyses. Compounds 1 - 3 were tested for their in vitro inhibitory activity against the growth of human tumor cell lines SMMC-7721, HeLa and MCF7; all of them displayed marked cytotoxic activities against cells SMMC-7721 and HeLa with IC (50) values ranging from 8.6 microM to 58.5 microM, yet no activity against the cell line MCF7 was detected.
Li
Youbin
Y
Department of Natural Product Chemistry, Jiangsu Provincial Institute of Traditional Chinese Medicine, Shizi Street 100, Hongshan Road, Nanjing, P. R. China. liyoubinli@sohu.com
Zhang
Jianfeng
J
Gu
Xiaojie
X
Peng
Yunru
Y
Huang
Weihua
W
Qian
Shihui
S
D045744:Cell Line, Tumor; D031105:Cynanchum / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification*
D003603:Cytotoxins; D006027:Glycosides; D011278:Pregnanes