Relationships between vascular indexes and atherosclerotic risk factors in patients with type 2 diabetes mellitus.
The relationships of cardio-ankle vascular index, (a new indicator of arterial stiffness), common carotid artery intima-media thickness, and ankle-brachial pressure index with atherosclerotic risk factors were compared in patients with type 2 diabetes. There were significant correlations between each pair of the above vascular indexes. Both cardio-ankle vascular index and intima-media thickness showed significant correlations with age, systolic blood pressure, pulse pressure, and serum total cholesterol. Ankle-brachial pressure index showed a significant negative correlation with pulse pressure but not with systolic blood pressure and total cholesterol. Logistic regression analysis showed that cardio-ankle vascular index and intima-media thickness were associated with systolic blood pressure and pulse pressure independently of age. These results suggest that there are significant associations among the 3 vascular indexes and that systolic blood pressure and pulse pressure are major, age-independent determinants of cardio-ankle vascular index and common carotid artery intima-media thickness in patients with diabetes.
Wakabayashi
Ichiro
I
Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Hyogo, Japan. wakabaya@hyo-med.ac.jp
Masuda
Hiroshi
H
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000098:blood supply; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000502:physiology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D019722:Sphygmomanometers; D013599:Systole / Q000502:physiology; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D014463:Ultrasonography
D002784:Cholesterol; D005340:Fibrinogen; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human