[Association of the XRCC1 and hOGG1 polymorphisms with the risk of laryngeal carcinoma].
OBJECTIVE
To evaluate the association between the polymorphisms of X-ray repair cross complementing group 1 (XRCC1) and human 8-oxoguanine glycosylase I (hOGG1) gene and the risk for laryngeal carcinoma.


METHODS
This is a case-control study comprised of two groups: 72 patients with laryngeal squamous carcinoma, and 72 controls without laryngeal carcinoma. The PCR-restriction fragment length polymorphism method was used to analyze the XRCC1-Arg399Gln, hOGG1-Ser326Cys polymorphisms.


RESULTS
The frequencies of XRCC1-399Arg/Gln+ Gln/Gln and hOGG1-326Ser/Cys+ Cys/Cys genotypes in the case group were higher than that of the control group(P< 0.05). There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively. No statistically significant differences were found between the smoking group and non-smoking group for risk of laryngeal carcinoma.


CONCLUSIONS
The amino acid replacement of XRCC1-399Arg to Gln and hOGG1-326Ser to Cys might lead to an increased risk of laryngeal carcinoma. The study demonstrated the positive association between the polymorphisms of XRCC1 and hOGG1 genes and laryngeal carcinoma.
Yang
Yuan
Y
Department of Laboratory Medicine, Huaihua Medical College, Huaihua, Hunan, 418000 P. R. China. yang1977yuan@yahoo.com.cn
Tian
He
H
Zhang
Zhi-jun
ZJ
D000368:Aged; D002277:Carcinoma / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human