Risk factors for cervical cancer in China: a case-control study.
OBJECTIVE
To determine the prevalence of human papillomavirus types and investigate the risk factors for cervical cancer in Hubei, China.


METHODS
We conducted a case-control study to investigate risk factors.


RESULTS
HPV DNA was detected in 94.55% of patients with cervical carcinoma, and 23.64% of control subjects. The most common HPV type in cervical cancer was HPV type 16 (81.82%), followed by HPV 58 (6.36%). HPV infected patients have a higher risk of developing cervical carcinoma, which is 75.79 times more than non-infected people. The other risks were age at first intercourse (p = 0.017) and number of live births (p = 0.032). A history of previous cytologic screening was associated with a substantial reduction in risk (p = 0.001).


CONCLUSIONS
The three principal reasons that Hubei has a high rate of women developing cervical carcinoma are HPV infection, age at first sexual intercourse and number of live births. Cervical cytology screening provides efficacious protection.
Cai
H B
HB
Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, P.R. China. chb2105@sohu.com
Ding
X H
XH
Zhou
Y F
YF
Lie
D M
DM
D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000145:classification; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000821:virology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000145:classification* / Q000453:epidemiology; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors; D012725:Sexual Behavior; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology*