title: Apical transporters for neutral amino acids: physiology and pathophysiology.
abstract: Absorption of amino acids in kidney and intestine involves a variety of transporters for different groups of amino acids. This is illustrated by inherited disorders of amino acid absorption, such as Hartnup disorder, cystinuria, iminoglycinuria, dicarboxylic aminoaciduria, and lysinuric protein intolerance, affecting separate groups of amino acids. Recent advances in the molecular identification of apical neutral amino acid transporters has shed a light on the molecular basis of Hartnup disorder and iminoglycinuria.
authors.affiliation: School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia. stefan.broeer@anu.edu.au
authors.forename: Stefan
authors.initials: S
authors.lastname: Bröer
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000737:chemistry* / Q000502:physiology*; D000818:Animals; D006250:Hartnup Disease / Q000503:physiopathology*; D006801:Humans; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D026921:Amino Acid Transport Systems, Neutral