Searching for molecular players differentially involved in neurotransmitter and neuropeptide release.
Neurotransmitters and neuropeptides are stored in small clear vesicles (SCVs) and large dense core vesicles (LDCVs), respectively. Many differences in the properties of SCVs and LDCVs suggest that these two classes of secretory organelles may employ different sets of molecules in exocytosis. Relatively little is known, however, about factors that differentially participate in SCVs and LDCVs release. This article briefly overviews some key molecules that are possibly involved in the differential regulation of the trafficking, docking, priming and fusion of SCVs and LDCVs.
Xu
Tao
T
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China. xutao@ibp.ac.cn
Xu
Pingyong
P
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002118:Calcium / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011493:Protein Kinase C / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism*; D050857:Synaptotagmins / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000502:physiology
C510820:Cadps protein, mouse; D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; C107581:UNC-31 protein, C elegans; D050857:Synaptotagmins; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D020691:rab GTP-Binding Proteins; D002118:Calcium