RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres.
In vertebrate cells, the small ubiquitin-like modifier SUMO plays a poorly defined role in targeting DNA topoisomerase II (TopoII) to centromeres (CENs) during mitosis, presumably to facilitate the untangling of sister chromatids as cells transition into anaphase. A new study by Dawlaty in the April 4 issue of Cell identifies the nucleoporin RanBP2 as a novel tumor suppressor that acts as a SUMO ligase for TopoII. Analysis of this interaction reveals TopoII recruitment to CENs is likely to play an important role in preventing chromosome segregation errors that lead to cancer.
Navarro
Michelle S
MS
Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.
Bachant
Jeff
J
D000818:Animals; D002503:Centromere / Q000378:metabolism*; D002869:Chromosome Aberrations; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D051379:Mice; D018832:Molecular Chaperones / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D011485:Protein Binding; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D014981:Xenopus
D018832:Molecular Chaperones; D028861:Nuclear Pore Complex Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D025521:Tumor Suppressor Proteins; C094493:ran-binding protein 2; D004250:DNA Topoisomerases, Type II