title: Anti-hyperglycemic activity of kiwifruit leaf (Actinidia deliciosa) in mice.
abstract: The methanol extract of kiwifruit leaf suppressed the postprandial blood glucose level after an oral administration of soluble starch or sucrose in mice. The mechanism of action is proposed to be due to the alpha-amylase-inhibiting activity in the 90% aqueous methanol fraction and alpha-glucosidase-inhibiting activity in the n-buthanol fraction, based on the results of in vitro experiments.
authors.affiliation: Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan, Minato-ku, Tokyo 108-8477, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Shirosaki
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazunaga
authors.initials: K
authors.lastname: Yazawa
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D013213:Starch / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D013395:Sucrose; D013213:Starch; D000516:alpha-Amylases; D000520:alpha-Glucosidases