Synthesis and DNA binding ability of cyclam-amino acid conjugates.
N-Substituted cyclam-amino acid conjugates have been synthesised both in solution and on the solid phase. The DNA binding affinity of these species has been studied: the nature of the amino acid strongly influences the change in melting temperature suggesting that simple cyclam-peptide conjugates could interact with DNA in a highly selective manner.
Venkata Ramana
A
A
School of Chemistry, University of Sydney, NSW 2006, Australia.
Watkinson
Michael
M
Todd
Matthew H
MH
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis / Q000378:metabolism; D019380:Anti-HIV Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis / Q000378:metabolism; D008956:Models, Chemical; D008969:Molecular Sequence Data; D013696:Temperature
D000596:Amino Acids; D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D047029:Lactams, Macrocyclic; D004247:DNA