Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors.
Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide.
Kiss
László E
LE
BIAL-Portela and Ca, Trofa, Portugal.
Ferreira
Humberto S
HS
Learmonth
David A
DA
D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry
D009539:Nicotinic Acids; D009570:Nitriles