Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation.
A modified alkalizing supplementation (MAS) was tested on skeletal muscle metabolism in aged rats undergoing exhaustive exercise. Aged Wistar rats were allocated into two groups: saline (A) and saline added with 16 mg of MAS (B) before treadmill exercise. Blood and gastrocnemius and soleus muscle were analyzed after exercise for succinate dehydrogenase (SDH), acetylcarnitine (ALCAR), and glycogen. Lactic acid (LA), creatin-phosphokinase (CPK), and gas analysis were tested in the blood. Exercise caused a significant increase of LA and CPK and muscle glycogen fall. Arterial desaturation at exhaustion was prevented in the B group (p < 0.05). Exercise-induced increase of SDH and ALCAR was further enhanced in B rats (p < 0.05). This study suggests that MAS can improve fast and endurance muscle metabolism in aged rats by increasing cellular acetyl group availability and tricarboxylic acid turnover.
Marotta
Francesco
F
GAIA Age-Management Foundation, Pavia, Italy. fmarchimede@libero.it
Chui
De Hua
de H
Lorenzetti
Aldo
A
Fayet
Flavia
F
Liu
Tsin
T
Marandola
Paolo
P
D000108:Acetylcarnitine / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001784:Blood Gas Analysis; D003402:Creatine Kinase / Q000378:metabolism; D019587:Dietary Supplements; D006003:Glycogen / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism
D019344:Lactic Acid; D000108:Acetylcarnitine; D006003:Glycogen; D013385:Succinate Dehydrogenase; D003402:Creatine Kinase