title: Brushed aside and silenced.
abstract: Mammalian genomes are highly organized in the 3D space of cell nuclei, but whether this affects gene function is unclear. Three papers now show that spatial relocation of a gene directly affects expression, and surprisingly, that of its neighbors.
authors.affiliation: Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
authors.forename: Lyubomira
authors.initials: L
authors.lastname: Chakalova
authors.forename: Peter
authors.initials: P
authors.lastname: Fraser
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000378:metabolism; D045584:Chromosome Positioning; D005786:Gene Expression Regulation / Q000502:physiology*; D020868:Gene Silencing; D016678:Genome; D014158:Transcription, Genetic