Aurocitrin and related polyketide metabolites from the wood-decay fungus Hypocrea sp. BCC 14122.
The known gentisaldehyde antibiotic aurocitrin (1), its cis-olefinic isomer (2), a salicylaldehyde analogue (3), two new benzofuran derivatives (4 and 5), and a new dihydroisocoumarin (6) were isolated from the wood-decay fungus Hypocrea sp. BCC 14122. The structures were elucidated primarily by NMR and mass spectroscopic analyses.
Berkaew
Pitchapa
P
Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Soonthornchareonnon
Noppamas
N
Salasawadee
Kitlada
K
Chanthaket
Rungtiwa
R
Isaka
Masahiko
M
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002522:Chlorocebus aethiops; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D035901:Hypocrea / Q000737:chemistry*; D007624:KB Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D014709:Vero Cells; D014934:Wood / Q000382:microbiology
D000447:Aldehydes; D000962:Antimalarials; D000970:Antineoplastic Agents; D001572:Benzofurans; D003374:Coumarins; C530242:aurocitrin