Clinicopathological features of lipomas with gene fusions involving HMGA2.
BACKGROUND
Despite accumulating knowledge of chimeric genes derived from fusion of the HMGA2 gene with multiple partners in lipomas, the different clinicopathological features of lipomas depending on different gene aberrations have not been well documented. The purpose of this study was to examine the clinical significance of the expression of fusion genes in lipomas.


METHODS
The expressions of three previously reported gene fusion transcripts, including HMGA2/LPP, HMGA2/RDC1 and HMGA2/NFIB, were analyzed in 102 tumors from patients with lipomas.


RESULTS
There were 23 cases (22.5%) expressing HMGA2/LPP, 2 cases (1.9%) expressing HMGA2/RDC1 and no cases of HMGA2/NFIB expression (0%). There were no significant intergroup differences in age, gender, body mass index, tumor size or location. The magnetic resonance images and pathological features were also not different in regard to the status of fusion gene expression.


CONCLUSIONS
There were no significant differences of clinicopathological features in patients with lipoma with or without these fusion gene transcripts.
Hatano
Hiroshi
H
Department of Orthopaedic Surgery, Niigata Cancer Center Hospital, Niigata, Japan. hatanoh@niigata-cc.jp
Morita
Tetsuro
T
Ogose
Akira
A
Hotta
Tetsuo
T
Kobayashi
Hiroto
H
Segawa
Hiroyuki
H
Uchiyama
Toru
T
Takenouchi
Tatsuya
T
Sato
Toyoji
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D050939:Gene Fusion; D024003:HMGA Proteins / Q000235:genetics; D025743:HMGA2 Protein / Q000235:genetics*; D006801:Humans; D008067:Lipoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051839:NFI Transcription Factors / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D054387:Receptors, CXCR / Q000235:genetics
C501896:ACKR3 protein, human; D024003:HMGA Proteins; D025743:HMGA2 Protein; C502535:HMGA2-LPP fusion protein, human; D051839:NFI Transcription Factors; C110754:NFIB protein, human; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D054387:Receptors, CXCR