[Restoring effect of noradrenalne on diminished neurogenic vasoreactivity].
The effect of 0.01-1.0 microM noradrenali on response to electrical field stimulation (EFS) of the juvenile rat tail artery segment was studied. Noradrenali was shown to potentiate the EFS-evoked constriction decreased in the course of experiments or in the acidic solution (pH 6.6) and this potentiation was proportional to the extent of the preceding decrease of the constriction. The more decreased was the EFS-evoked constriction the higher was the noradrenali concentration which produced the maximal potentiation and the wider was the potentiative noradrenali concentration range. The potentiative effect of noradrenali was not prevented by the NO synthase inhibitor NG-nitro-L-arginine. The results suggest that noradrenali can restore the diminished neurogenic reactivity of blood vessels, and this effect is not connected with the change in the NO production.
Karachentseva
O V
OV
Iartsev
B N
BN
Dvoretskiĭ
D P
DP
D000818:Animals; D001158:Arteries / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D019335:Nitroarginine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D014662:Vasoconstrictor Agents; D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009638:Norepinephrine