Enhancing effect of mirtazapine on cognitive functions associated with prefrontal cortex in patients with recurrent depression.
BACKGROUND
We put forward a hypothesis that a therapeutic administration of mirtazapine to depressed patients, due to pharmacological profile of the drug, could enhance cognitive functions associated with prefrontal cortex activity.


METHODS
The study was performed on depressed patients receiving mirtazapine for the period of 6 months. Neuropsychological assessments after 3 and 6 months of treatment were performed by the Wisconsin Card Sorting Test, N-back test, TMT and Stroop tests.


RESULTS
During acute depressive episode, a significant impairment on all neuropsychological tests was evident. Substantial improvement in performance has been noted after 3 and 6 months of mirtazapine treatment, and, after 6 months, a majority of the investigated patients achieved the results within the range of matched healthy control subjects. Improvement on neuropsychological tests after treatment with mirtazapine showed no correlation with the degree of amelioration of depression.


CONCLUSIONS
Mirtazapine may exert a favorable influence on cognitive functions associated with prefrontal cortex in depressed patients. The lack of direct correlation with improvement of depressive symptoms suggests that mirtazapine may possess specific pro-cognitive properties.
Borkowska
Alina
A
Clinical Neuropsychology Unit, Nicolaus Copernicus University, Torun, Collegium Medicum, Bydgoszcz, Poland.
Drozdz
Wiktor
W
Ziółkowska-Kochan
Marzena
M
Rybakowski
Janusz
J
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000494:pharmacology*; D016022:Case-Control Studies; D003071:Cognition / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008875:Middle Aged; D000078785:Mirtazapine; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000187:drug effects*; D011594:Psychometrics; D016896:Treatment Outcome
D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D000078785:Mirtazapine