title: A case of prostatic duct adenocarcinoma: its clinical significance in comparison with typical acinar adenocarcinoma.
abstract: We report a case of prostatic duct adenocarcinoma treated with radical prostatectomy. Advanced pathological stage (pT3bpN1) was beyond the prediction of the favorable preoperative parameters (cT1cN0, PSA 7.64 ng/ml). The main tumor of ductal adenocarcinoma was occupying the transitional zone and surrounded by scattered micro-foci of acinar adenocarcinoma. We identified coexistence of ductal and acinar adenocarcinoma cells side by side in the same gland. Pure ductal cancer cells were detected in the metastasized lymph node without acinar cancer cells. Strong staining of PSA and loss of p63 expression by both types of adenocarcinoma cells were confirmed immunohistochemically. We discuss the clinical significance of prostatic duct adenocarcinoma in comparision with typical acinar adenocarcinoma.
authors.affiliation: Department of Urology, Tokyo Medical and Dental University Graduate School.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Takazawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawakami
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kubo
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kageyama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kihara
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*