title: Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir.
abstract: Infection with Herpes simplex virus type 1 (HSV-1) typically causes lesions of the mouth, face, skin, esophagus, or brain. Herpes simplex virus type 2 (HSV-2) usually causes infections of the genitals, rectum, skin, hands, or meninges. The herpes viruses are a major cause of blindness from keratitis. The usual drugs used for herpes are Vidarabine, Acyclovir, Penciclovir and Ganciclovir; they are associated with several complications. The aim of this study was to investigate if a formulation containing 2.5 mg melatonin and 100 mg SB-73 would help patients with herpes, and to compare the preparation with 200 mg Acyclovir. SB-73 is a mixture of magnesium, phosphate, fatty acids extracted from Aspergillus sp. which has anti-herpes virus properties. A single blind randomized study was performed in which 70 patients underwent treatment using the supplement cited above (group A) and 75 received treatment of 200 mg Acyclovir (group B). Sixty-seven patients of the group A (95.7%) reported a complete regression of symptoms after 7 days of treatment. By comparison, 64 subjects (85.3%) of the Acyclovir reported regression of symptoms in the same period. There was statiscally significant difference between the groups (P < 0.05).
authors.affiliation: Universidade Federal de São Carlos, Departamento de Fisioterapia, Dr. Nivaldo's laboratory, Rod. Washington Luís, São Carlos, SP, Brazil.
authors.forename: Odilon da Silva
authors.initials: Oda S
authors.lastname: Nunes
authors.forename: Ricardo de Souza
authors.initials: Rde S
authors.lastname: Pereira
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D001766:Blindness / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000821:virology; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D005260:Female; D006558:Herpes Genitalis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000821:virology; D008041:Linoleic Acids / Q000008:administration & dosage*; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D016037:Single-Blind Method
chemical_list: D000998:Antiviral Agents; D002492:Central Nervous System Depressants; D008041:Linoleic Acids; D009943:Organophosphorus Compounds; C076534:magnesium ammonium phospholinoleate anhydride; D008550:Melatonin; D000212:Acyclovir