title: Clinicopathological characteristics of cervical cancer between 2003 and 2005, after the introduction of a national cancer screening program in Slovenia.
abstract: OBJECTIVE
  An organized cervical cancer (CC) screening program was introduced in Slovenia in 2003. With the purpose of clinical audit we analyzed the clinicopathological characteristics of CC patients for the period between 2003 and 2005.
  
  
  METHODS
  The retrospectively collected data of 450 CC patients were presented at three Advisory Boards of Gynecologic Oncology in Slovenia. They were stratified for stage, tumor characteristics and treatment methods according to gynecologic examination attendance in the last 5 years preceding the diagnosis of CC (attenders vs. nonattenders).
  
  
  RESULTS
  In the period of observation, 242 women (53.8%) visited their gynecologists in the 5-year period prior to diagnosis of CC. Squamous cell carcinoma was present in 378 women (84.0%), adenocarcinoma in 45 (10.0%), adenosquamous carcinoma in 24 (5.3%) and other types in 3 women (0.7%). Attenders were significantly more frequently diagnosed with squamous cell carcinoma than nonattenders (chi-square=5.13; P<0.05). Attenders were significantly more frequently diagnosed in stage IA than in stage IB (chi-square=22.35; P<0.01). Similarly, in attenders stage I was significantly more frequent than stage II (chi-square=18.81; P<0.01). Pathologic smears of women with CC in the last 5-year period were most frequently evaluated as Pap II in the years 2003 and 2004 (in 39.1 and 26.4% of women, respectively) and as Pap III (in 27.9% of women) in 2005. Surgery was performed in 282 women (62.7%), radiotherapy in 158 (35.1%), symptomatic therapy in 9 (2.0%) and chemotherapy alone in 1 (0.2%) woman. In attenders, surgery alone was the most frequent treatment method (chi-square=91.18; P<0.01).
  
  
  CONCLUSIONS
  Only in attenders a significant redistribution of CC stages in favor of early stages is observed, and in these women more conservative and less extensive treatment methods could be applied.
authors.affiliation: University Department of Gynecology and Perinatology, Maribor University Hospital, Ljubljanska 5, 2000 Maribor, Slovenia. iztok.takac@sb-mb.si
authors.forename: Iztok
authors.initials: I
authors.lastname: Takac
authors.forename: Marjetka
authors.initials: M
authors.lastname: Ursic-Vrscaj
authors.forename: Alenka
authors.initials: A
authors.lastname: Repse-Fokter
authors.forename: Tatjana
authors.initials: T
authors.lastname: Kodric
authors.forename: Stelio
authors.initials: S
authors.lastname: Rakar
authors.forename: Andrej
authors.initials: A
authors.lastname: Mozina
authors.forename: Spela
authors.initials: S
authors.lastname: Smrkolj
authors.forename: Maja
authors.initials: M
authors.lastname: Primic-Zakelj
authors.forename: Vida
authors.initials: V
authors.lastname: Strzinar
authors.forename: Ales
authors.initials: A
authors.lastname: Vakselj
authors.forename: Darja
authors.initials: D
authors.lastname: Arko
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009367:Neoplasm Staging; D015995:Prevalence; D017524:Slovenia; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology