The role of myo-inositol in the pathogenesis of diabetic complications.
It is tempting to speculate that all diabetic complications are generated by a single biochemical abnormality. The observation that intracellular inositol depletion occurs in diabetes mellitus has led to the hypothesis that this may be of importance in the pathogenesis of diabetic complications. The central role of inositol and inositol derivatives in cellular function has given support to this theory, but as yet no fully substantiated mechanistic model can be offered.
Baxter
M A
MA
Lecturer and Honorary Senior Registrar in the Department of Medicine, University of Birmingham, B15 2TH Birmingham, United Kingdom.