Neural phenotypes of common and rare genetic variants.
Neuroimaging methods offer a powerful way to bridge the gaps between genes, neurobiology and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with particular neurobehavioral phenotypes, which can help to localize causative genes and better understand the genetics of complex traits in the general population. Here we review the evidence from studies using these convergent approaches to investigate genetic influences on brain structure: (1) studies of common genetic variations associated with particular neuroanatomic phenotypes, and (2) studies of possible 'genetic subtypes' of neuropsychiatric disorders with very high penetrance, with a focus on neuroimaging studies using novel computational brain mapping algorithms. Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population.
Bearden
Carrie E
CE
Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States. cbearden@mednet.ucla.edu
Glahn
David C
DC
Lee
Agatha D
AD
Chiang
Ming-Chang
MC
van Erp
Theo G M
TG
Cannon
Tyrone D
TD
Reiss
Allan L
AL
Toga
Arthur W
AW
Thompson
Paul M
PM
D000818:Animals; D002869:Chromosome Aberrations; D014644:Genetic Variation; D006801:Humans; D009154:Mutation / Q000502:physiology; D009420:Nervous System / Q000033:anatomy & histology*; D009422:Nervous System Diseases / Q000235:genetics* / Q000503:physiopathology*; D010641:Phenotype