Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor.
Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature. To our knowledge, there are no previous reports on the cytogenetics of this lesion. Reported here is a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman. Subsequent cytogenetic analysis revealed a clonal reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3. This, in addition to its characteristic morphology and immunophenotype, supports the neoplastic nature of this tumor and may aid in its diagnosis.
Wettach
George R
GR
Department of Pathology, Oregon Health & Science University, Mail code L471, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Boyd
Luke J
LJ
Lawce
Helen J
HJ
Magenis
R Ellen
RE
Mansoor
Atiya
A
D000328:Adult; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005260:Female; D005350:Fibroma / Q000235:genetics / Q000473:pathology*; D005533:Foot Dermatoses / Q000235:genetics / Q000473:pathology*; D006486:Hemosiderosis / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D008068:Lipomatosis / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic