title: [Dutch study on the optimal treatment strategy for patients with a first or second occurrence of gastro-oesophageal variceal bleeding: the TIPS-TRUE trial].
abstract: The main options for secondary prevention of gastrooesophageal variceal bleeding are endoscopic therapy and treatment with propranolol. Creation ofa transjugular intrahepatic portosystemic shunt (TIPS) is currently considered a valuable secondary 'rescue' treatment when other therapies fail. Recent data suggest that the use of covered stents markedly increases the efficacy of TIPS, compared with conventional uncovered stents. Therefore, a multicentre randomised trial was designed to compare the effects of TIPS using covered stents with those of endoscopic therapy plus propranolol in patients with a first or second episode ofgastro-oesophageal variceal bleeding. TIPS will be performed in 4 university centres with relevant expertise. The trial will hopefully gain nationwide support, and all centres in The Netherlands are cordially invited to participate.
authors.affiliation: Afd. Maag-, Darm- en Leverziekten, Erasmus MC, Postbus 2040, 3000 CA Rotterdam. h.vanbuuren@erasmusmc.nl
authors.forename: H R
authors.initials: HR
authors.lastname: van Buuren
authors.forename: A
authors.initials: A
authors.lastname: Wils
authors.forename: E A J
authors.initials: EA
authors.lastname: Rauws
authors.forename: B
authors.initials: B
authors.lastname: van Hoek
authors.forename: J P H
authors.initials: JP
authors.lastname: Drenth
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuipers
authors.forename: P M T
authors.initials: PM
authors.lastname: Pattynama
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D004932:Esophageal and Gastric Varices / Q000188:drug therapy / Q000517:prevention & control* / Q000601:surgery; D006801:Humans; D008026:Ligation; D009426:Netherlands; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D011433:Propranolol / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol