Linking inflammasome activation and phagosome maturation.
One-third of the world's population is infected with Mycobacterium tuberculosis, one of the most effective human pathogens, whose success is attributed to the deployment of remarkably sophisticated immune evasion mechanisms. In this issue of Cell Host & Microbe, a new study unravels a novel strategy of immune evasion and enhanced bacterial intracellular survival, which is dependent on inhibition of inflammasome activation by an M. tuberculosis-encoded metalloprotease.
Lazarevic
Vanja
V
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115, USA.
Martinon
Fabio
F
D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology*; D053468:CARD Signaling Adaptor Proteins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002454:Cell Differentiation; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D015536:Down-Regulation; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D053583:Interleukin-1beta / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000378:metabolism; D045726:Metalloproteases / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000201:enzymology / Q000472:pathogenicity; D010588:Phagosomes / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000502:physiology; D015398:Signal Transduction; D014376:Tuberculosis / Q000276:immunology
D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; D003598:Cytoskeletal Proteins; D053583:Interleukin-1beta; C435692:NLRC4 protein, human; D017472:Receptors, Interleukin-1; D045726:Metalloproteases