Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis.
OBJECTIVE
The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis.


METHODS
The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49+/-13) and 30 active AS patients (males/females: 15/15, mean age: 36+/-12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52+/-8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41+/-7) as control groups for RA and AS, respectively.


RESULTS
MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p<0.001, AS vs healthy subjects p<0.001). After treatment MPV values significantly increased in AS and RA (p<0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p=0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r=-0.507; p=0.004).


CONCLUSIONS
Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA.
Kisacik
Bunyamin
B
Hacettepe Medical Faculty, Rheumatology Department, Ankara, Turkey. Bunyamin_k@hotmail.com
Tufan
Abdurrahman
A
Kalyoncu
Umut
U
Karadag
Omer
O
Akdogan
Ali
A
Ozturk
Mehmet Akif
MA
Kiraz
Sedat
S
Ertenli
Ihsan
I
Calguneri
Meral
M
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood; D015539:Platelet Activation; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000276:immunology*
D015415:Biomarkers