title: CCR5 is involved in controlling the early stage of Cryptosporidium parvum infection in neonates but is dispensable for parasite elimination.
abstract: Chemokines play a critical role in immune cell trafficking and the transition from an innate to an acquired immune response. We analyzed host response in neonatal mice deficient in chemokine receptor CCR5 following infection with the intracellular protozoan parasite Cryptosporidium parvum. CCR5 neonatal mice had a higher parasite burden at the early stage of infection but eliminated the parasite as efficiently as their wild-type counterparts. The higher sensitivity of neonates at the beginning of infection was not due to an altered IFNgamma response. An increased CCR2-attracting chemokine response associated with the recruitment of CCR2-positive cells in the infected mucosa may have compensated for the absence of CCR5. A lack of CCR5 thus has an impact in the early stage of C. parvum infection in neonates, but this receptor is dispensable for subsequent parasite elimination.
authors.affiliation: Laboratoire Contrôle et Immunologie des Maladies Entériques du Nouveau-né, INRA, UR1282, Infectiologie Animale et Santé Publique, F-37380 Nouzilly, France. slacroix@tours.inra.fr
authors.forename: Sonia
authors.initials: S
authors.lastname: Lacroix-Lamandé
authors.forename: Roselyne
authors.initials: R
authors.lastname: Mancassola
authors.forename: Gaël
authors.initials: G
authors.lastname: Auray
authors.forename: Nelly
authors.initials: N
authors.lastname: Bernardet
authors.forename: Fabrice
authors.initials: F
authors.lastname: Laurent
mesh_terms: D000818:Animals; D003457:Cryptosporidiosis / Q000276:immunology*; D016785:Cryptosporidium parvum / Q000302:isolation & purification / Q000502:physiology*; D007371:Interferon-gamma / Q000096:biosynthesis; D007422:Intestines / Q000469:parasitology; D051379:Mice; D054390:Receptors, CCR2 / Q000096:biosynthesis / Q000276:immunology; D019713:Receptors, CCR5 / Q000172:deficiency / Q000276:immunology*
chemical_list: D054390:Receptors, CCR2; D019713:Receptors, CCR5; D007371:Interferon-gamma