Vascular endothelial growth factor targeted RNA interference as a modulator of angiogenesis.
Angiogenesis is important in the pathogenesis of cancer and ischemic heart disease. Vascular endothelial growth factor targeted RNA interference is a very promising tool for modulation of blood vessel growth as recent studies show. This article tries to summarize the basic ideas behind the experimental use of RNA interference to regulate angiogenesis.
Celec
Peter
P
Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic. petercelec@gmail.com
Yonemitsu
Yoshikazu
Y
D000818:Animals; D005786:Gene Expression Regulation; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
D042461:Vascular Endothelial Growth Factor A