The thyroglobulin gene: evolutionary and regulatory issues.
The coding information for thyroglobulin synthesis is contained in a large transcription unit, which is made from the juxtaposition of short repetitive gene modules and of a copy of an ancient acetylcholinesterase homologue. Minor alternatively spliced transcripts with conservation of the reading frame seem to be common. Whether they have a role or represent noise in the splicing phenomena is unknown. Transcription of the thyroglobulin gene is controlled by cAMP through a pathway involving sequence motifs and trans-acting factors that differ from those identified so far in other systems.
Christophe
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IRIBHN, Faculté de Médecine, Université Libre de Bruxelles, Bruxelles, Belgium.
Vassart
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