title: [Urate production and regulation].
abstract: The amount of urate depends on the balance between production and excretion. Although only about 10% of hyperuricemia results from overproduction of urate, purine biosynthesis has substantial impacts on the pathogenesis of hyperuricemia. Here, regulation of purine biosynthesis pathway and relevant mechanisms are discussed. Genetic mechanisms for urate overproduction, dietary effects on urate amount and new drug therapy inhibiting urate production are also discussed.
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morisaki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Morisaki
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D011687:Purines / Q000096:biosynthesis; D012268:Ribose-Phosphate Pyrophosphokinase / Q000235:genetics; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D011687:Purines; D014527:Uric Acid; D000255:Adenosine Triphosphate; D007041:Hypoxanthine Phosphoribosyltransferase; D012268:Ribose-Phosphate Pyrophosphokinase; C030985:purine