Calcitonin Gene-related Peptide (CGRP) is a Mediator of Vascular Adaptations During Hypertension in Pregnancy.
Hypertension during pregnancy is a serious obstetrical problem, and the pathophysiology of pre-eclampsia is unclear. Evidence is presented that calcitonin gene-related peptide (CGRP) plays a role in the vascular adaptations that occur during pregnancy. In addition, CGRP might be critical for compensatory vasodilatory changes that occur in response to hypertensive insults during pregnancy, and these compensatory mechanisms might require adequate progesterone activity. Thus, we suggest that an inadequate CGRP-mediated compensatory vasodilatory (adaptative) response may play a role in the pathophysiology of hypertensive disorders during pregnancy.
Yallampalli
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Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Wimalawansa
S J
SJ