Combination therapy with oral antihyperglycemic agents in the treatment of non-insulin-dependent diabetes mellitus.
Combination therapy, using drugs from different classes of oral hypoglycemic agents, offers several advantages in the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Appropriate combinations can significantly improve glycemia and often obviate insulin treatment. In general, no increased toxicity or significant interactions are observed.
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St. Michael's Hospital, Toronto, Ontario M5C 2T2, Canada; University of Toronto, Canada.