[Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I].
Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.
Schulze
R
R
II. Medizinische Klinik, Klinikum Augsburg, Stenglinstrasse 2, 86156, Augsburg, Deutschland. ralf.schulze@2med.zk.augsburg-med.de
Behr
W
W
Wittwer
H
H
Harwix
S
S
Murmann
K
K
V Scheidt
W
W
Ehret
W
W
Schlimok
G
G
D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects; D003374:Coumarins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009336:Necrosis / Q000139:chemically induced / Q000188:drug therapy; D011486:Protein C / Q000008:administration & dosage*; D020151:Protein C Deficiency / Q000139:chemically induced* / Q000188:drug therapy*
D000925:Anticoagulants; D003374:Coumarins; D011486:Protein C; C030123:coumarin