The use of stem cells in the treatment of inoperable limb ischemia.
Autologous stem cell-based therapy offers many advantages over other nonsurgical treatments of peripheral arterial disease. Transplant stem cells are a renewable source of multiple cytokines and growth factors. Autologous adult stem cells are not rejected and do not form teratomas. Early preliminary results indicate that adult stem cell therapy is safe and effective in patients with critical limb ischemia.
Pearce
William H
WH
Division of Vascular Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA. wpearce@nmh.org
Burt
Richard
R
Rodriguez
Heron E
HE
D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007511:Ischemia / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D014182:Transplantation, Autologous
D016179:Granulocyte Colony-Stimulating Factor