Dimethyl sulfide induced [3+2] annulation strategy: an efficient synthesis of functionalized dihydropyrazole derivatives using the Baylis-Hillman bromides.
Baylis-Hillman bromides have been successfully employed as a valuable source of 1,3-dipoles for cycloaddition onto dialkyl azodicarboxylates (dipolarophiles) under the influence of dimethyl sulfide and potassium carbonate to provide functionalized dihydropyrazole derivatives in a simple one-pot [3+2] annulation strategy.
Basavaiah
Deevi
D
School of Chemistry, University of Hyderabad, Hyderabad, India. dbsc@uohyd.ernet.in
Roy
Suparna
S
D001965:Bromides / Q000737:chemistry; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry
D001965:Bromides; D011720:Pyrazoles; D013440:Sulfides; C004784:dimethyl sulfide