Synthesis of (2-oxoindolin-3-ylidene)methyl acetates involving a C-H functionalization process.
A novel palladium-catalyzed oxidative C-H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAc)2 and PhI(OAc)2, a variety of N-arylpropiolamides underwent the C-H functionalization reaction with acids to afford the corresponding (E)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.
Tang
Shi
S
College of Chemistry and Materials Science, Wenzhou University, Wenzhou, China.
Peng
Peng
P
Wang
Zhi-Qiang
ZQ
Tang
Bo-Xiao
BX
Deng
Chen-Liang
CL
Li
Jin-Heng
JH
Zhong
Ping
P
Wang
Nai-Xing
NX
D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry*
D000085:Acetates; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D010165:Palladium; C046923:methyl acetate