No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes.
OBJECTIVE
Necrosis tumor factor (TNF) is known to be associated with diabetic retinopathy (DR). The objective of this study was to examine the genetic variations of TNF-alpha and assess their possible relationship to DR in type 2 diabetic patients in the Chinese population.


METHODS
We conducted a case-control association study between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes. We selected three variants in the promoter region of TNF-alpha, namely rs1800629, rs1041981, and rs2857713.


RESULTS
No individual SNP nor any haplotype was found to be associated with DR in our study.


CONCLUSIONS
This is the first study to report TNF-alpha polymorphisms in patients with DR in the Chinese population. The results suggest that the variants among the promoter of TNF-alpha are unlikely to play a major role in the susceptibility to DR in Chinese patients with type 2 diabetes.
Wang
N
N
Department of Ophthalmology, Shanghai Jiaotong University, Affiliated First People's Hospital, Shanghai, PR China.
Huang
K
K
Zou
H
H
Shi
Y
Y
Zhu
J
J
Tang
W
W
Xu
X
X
D000368:Aged; D044466:Asian People / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha