Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.
Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
Mendez
Ivar
I
Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy & Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.
Viñuela
Angel
A
Astradsson
Arnar
A
Mukhida
Karim
K
Hallett
Penelope
P
Robertson
Harold
H
Tierney
Travis
T
Holness
Renn
R
Dagher
Alain
A
Trojanowski
John Q
JQ
Isacson
Ole
O
D016380:Brain Tissue Transplantation / Q000379:methods / Q000473:pathology*; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D049268:Positron-Emission Tomography; D016896:Treatment Outcome; D014446:Tyrosine 3-Monooxygenase
D014446:Tyrosine 3-Monooxygenase