Holoprosencephaly in Ibadan, Nigeria: a report of three cases and review of literature.
Holoprosencephaly is a rare congenital malformation resulting from failure of cleavage of midline structures of the forebrain and face. It affects 0.49-1.2 in 10,000 births around the world. The nature of this condition in African children is not well documented in literature. We present a cluster of three cases of holoprosencephaly with varying degrees of facial and intracranial malformations seen within a 6 month period at the University College Hospital, Ibadan, Nigeria.
Tongo
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OO
Department of Paediatrics, College of Medicine, University of Ibadan/University College Hospital, Ibadan, Nigeria. ktongo2@yahoo.com
Lagunju
I A
IA
Ogun
G O
GO
Imam
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ZO
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D016142:Holoprosencephaly / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy