Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents.
Chiisanoside is the main component of Acanthopanax sessiliflorus leaves. Simultaneous administration of chiisanoside resulted in a decrease in the plasma TG level and increase of undigested TG in the intestinal lumen after oil gavage to mice. This suggests that chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.
Yoshizumi
Kazuma
K
Research Institute, Fundamental Research Faculty, Fancl Corporation, Yokohama, Kanagawa 244-0806, Japan.
Murota
Kaeko
K
Watanabe
Shiro
S
Tomi
Hironori
H
Tsuji
Tomoko
T
Terao
Junji
J
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D009821:Oils / Q000378:metabolism*; D009844:Oligosaccharides / Q000494:pharmacology*; D012450:Safflower Oil / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology*
D019440:Anti-Obesity Agents; D009821:Oils; D009844:Oligosaccharides; D014280:Triglycerides; D014315:Triterpenes; C507583:chiisanoside; D012450:Safflower Oil