title: A woman with synchronous cervical, vaginal and laryngeal squamous cell carcinomas and positive human papillomavirus type 16; case presentation with literature review.
abstract: During the last 25 years the development of cervical cancer and cancer of the anorectum has been related to human papillomavirus (HPV) infection. HPV infection is found in up to 99.7% of all cervical cancers. Head and neck squamous cell carcinomas (HNSCC) have also been related to HPV infection. In this communication we present a 67-year-old female patient, nonsmoker, diagnosed with 3 synchronous cancers--squamous cell carcinoma of the uterine cervix, vagina and larynx. The patient was found positive for immunoglobulin HPV 16 L1 using ELISA method. We believe that in the presented case, the high risk HPV subtype 16 was implicated in the etiology of laryngeal, cervical and vaginal cancers. We also think that HPV infection and related cancers could be prevented effectively by immunization.
authors.affiliation: Oncotherapeutic Clinic, Queen Giovanna Hospital, Sofia, Bulgaria.
authors.forename: S
authors.initials: S
authors.lastname: Georgieva
authors.forename: V
authors.initials: V
authors.lastname: Iordanov
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000821:virology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D014625:Vaginal Neoplasms / Q000473:pathology / Q000821:virology*