title: In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis complex isolated in Taiwan over 10 years.
abstract: Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid.
authors.affiliation: Section of Microbiology, Dept. of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Tsi-Shu
authors.initials: TS
authors.lastname: Huang
authors.forename: Yung-Ching
authors.initials: YC
authors.lastname: Liu
authors.forename: Cheng-Len
authors.initials: CL
authors.lastname: Sy
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
authors.forename: Hui-Zin
authors.initials: HZ
authors.lastname: Tu
authors.forename: Bao-Chen
authors.initials: BC
authors.lastname: Chen
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests / Q000592:standards; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D023303:Oxazolidinones / Q000494:pharmacology*; D013624:Taiwan / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D023303:Oxazolidinones; D000069349:Linezolid