title: The genetics of cancer survivorship.
abstract: Constitutional (hereditary) genetic variation and somatic genetic alterations acquired during transformation to the neoplastic phenotype are both critical determinants of cancer outcome, and can ultimately have a significant effect on cancer survivorship. This article discusses the role of constitutional and somatic genetics in determining outcome and survivorship following a diagnosis of cancer using illustrative examples primarily from the hematologic malignancies.
authors.affiliation: Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. james.allan@newcastle.ac.uk
authors.forename: James M
authors.initials: JM
authors.lastname: Allan
mesh_terms: D002869:Chromosome Aberrations / Q000187:drug effects; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000534:rehabilitation; D020641:Polymorphism, Single Nucleotide; D017741:Survivors