Antifungal activity of coumarins.
The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 microg/ml for Fusarium solani and 250 micro/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.
Montagner
Cristina
C
Departamento de Microbiologia e Parasitologia, Centro de Ciências Biológicas da Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil.
de Souza
Simone M
SM
Groposoa
Cláudia
C
Delle Monache
Franco
F
Smânia
Elza F A
EF
Smânia
Artur
A
D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D003374:Coumarins