title: Severe periodontitis in young adults is associated with sub-clinical atherosclerosis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the association between severe periodontitis and sub-clinical atherosclerosis in young (< or =40 years) systemically healthy individuals.
  
  
  METHODS
  Ninety systemically healthy subjects, 45 affected by severe periodontitis (mean age 36.35+/-3.65 years) and 45 controls without a history of periodontal disease (mean age 33.78+/-3.28 years), were enrolled in this study. Patients and controls were paired for age, gender, body mass index and smoking habits. Carotid intima-media thickness (IMT) was bilaterally assessed by ultrasonography at the level of common carotid artery. Traditional cardiovascular risk factors for atherosclerosis were also evaluated.
  
  
  RESULTS
  The overall mean carotid IMT was 0.82+/-0.13 mm in the test group and 0.72+/-0.07 mm in the control group ( p<0.0001). Stepwise regression analysis showed that periodontitis ( p<0.0001) and regular physical activity ( p=0.0009) were predictor variables of overall mean carotid IMT. When considering an IMT> or =0.82 mm as the critical index of increased cardiovascular risk, periodontal patients overcame this threshold compared with healthy patients by an odds ratio=8.55 [confidence interval 95%: 2.38; 39.81]. No investigated haemostatic variable was associated with increased carotid IMT.
  
  
  CONCLUSIONS
  Severe periodontitis is associated with sub-clinical atherosclerosis in young systemically healthy patients.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. cairofrancesco@virgilio.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Cairo
authors.forename: Sergio
authors.initials: S
authors.lastname: Castellani
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Gori
authors.forename: Michele
authors.initials: M
authors.lastname: Nieri
authors.forename: Giorgia
authors.initials: G
authors.lastname: Baldelli
authors.forename: Rosanna
authors.initials: R
authors.lastname: Abbate
authors.forename: Giovan Paolo
authors.initials: GP
authors.lastname: Pini-Prato
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000150:complications* / Q000473:pathology; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis; D017536:Carotid Artery, Common / Q000473:pathology; D016893:Carotid Stenosis / Q000150:complications / Q000473:pathology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009043:Motor Activity; D010518:Periodontitis / Q000150:complications* / Q000473:pathology; D017539:Tunica Intima / Q000473:pathology
chemical_list: D002097:C-Reactive Protein; D002784:Cholesterol