Membrane proteins as diagnostic biomarkers and targets for new therapies.
Membrane proteins, especially plasma membrane proteins, form one of the most interesting classes of proteins among disease biomarker candidates. Because of their localization on the surface of cells and organelles, membrane proteins also represent potential drug targets. In this review, developments in the characterization of membrane proteins and their role in the treatment of disease, in particular cancer treatment, are presented.
Josic
Djuro
D
Rhode Island Hospital, COBRE Center for Cancer Research Development, Proteomics Core, Suite 4, 206 Coro West, 1 Hoppin Street, Providence, RI 02903, USA. djuro_josic@brown.edu
Clifton
James G
JG
Kovac
Spomenka
S
Hixson
Douglas C
DC
D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis* / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D011499:Protein Processing, Post-Translational
D015415:Biomarkers; D008565:Membrane Proteins