Bioactive aristolactams from Piper umbellatum.
Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-dihydroxyphenyl)-N-2-[4-hydroxyphenylethyl]-2-propenamide, beta-amyrin, friedelin, apigenin 8-C-neohesperidoside, acacetin 6-C-beta-d-glucopyranoside, beta-sitosterol, its 3-O-beta-d-glucopyranoside and its 3-O-beta-d-[6'-dodecanoyl]-glucopyranoside. Glycosidase inhibition, antioxidant and antifungal activities of these compounds were evaluated. Compounds 1-3 showed moderate alpha-glucosidase enzyme inhibition with IC50 values 98.07+/-0.44, 43.80+/-0.56 and 29.64+/-0.46, respectively. In DPPH radical scavenging assay, compounds 2, 3 and 6 showed potent inhibitory activity while compounds 4, 5 and 7 showed potent antifungal activity.
Tabopda
Turibio Kuiate
TK
Laboratoire de Chimie Organique des Substances Naturelles, LC3-UMR 7177 CNRS, Université Louis Pasteur, Centre de Neurochimie, 5 Rue Blaise Pascal, 67084 Strasbourg, France. ttabopda@yahoo.fr
Ngoupayo
Joseph
J
Liu
Jiawei
J
Mitaine-Offer
Anne-Claire
AC
Tanoli
Sheraz A Khan
SA
Khan
Shamsun Nahar
SN
Ali
Muhammad Shaiq
MS
Ngadjui
Bonaventure Tchaleu
BT
Tsamo
Etienne
E
Lacaille-Dubois
Marie-Aleth
MA
Luu
Bang
B
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
D000470:Alkaloids; D000935:Antifungal Agents; D016166:Free Radical Scavengers; D006576:Heterocyclic Compounds, 4 or More Rings; D007769:Lactams; D010936:Plant Extracts