title: Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival.
abstract: The aim of the study was to determine the practicability of (18)F-FLT in tumours of the head and neck area in terms of visualization, a possible correlation between FLT uptake and proliferation fraction as determined by Ki-67 immunostaining, and if tumoural FLT-uptake has a prognostic meaning, as determined by a correlation to patient survival time. Results were compared to (18)F-FDG.
  
  
  METHODS
  20 patients with previously untreated lesions of the head and neck area, which were clinically highly suspicious to be malignant, underwent PET scans with (18)F-FLT and (18)F-FDG, a CT of the head and neck area, and a biopsy. Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). (18)F-FDG and (18)F-FLT uptake were compared with histopathologic and immunohistochemical results.
  
  
  RESULTS
  19 patients had malignant tumours; one patient had a benign cystadenoma (so called Warthin's tumour) of the parotid gland. One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with (18)F-FDG but showed only faint uptake with (18)F-FLT, resulting in a sensitivity of 95 % for both tracers. Of all lesions, maximum SUVs of (18)F-FLT ranged from 1.53 to 11.70 (mean +/- SD 5.81 +/- 2.28) those of FDG from 2.63 to 16.50 (mean +/- SD 8.91 +/- 3.58), p < 0.001. (18)F-FLT-T/N ranged from 0.94 to 5.85 (mean +/- SD, 3.18 +/- 1.21), (18)F-FDG-T/N was from 0.92 to 7.50 (mean +/- SD, 3.6 +/- 1.74), n.s. The mean survival time was 18 months in a maximum follow up time of 36 months. A significant correlation between both PET tracers and survival was detected, but no correlation between the amount of Ki-67 positive cells and FLT.
  
  
  CONCLUSIONS
  In head and neck cancer in the primary setting (18)F-FLT does not provide additional visual information in comparison to (18)F-FDG.(18)F-FLT uptake is inversely correlated with patient survival, as well as (18)F-FDG.
authors.affiliation: Department of Craniomaxillofacial Surgery, LKH Feldkirch, Feldkirch, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Linecker
authors.forename: C
authors.initials: C
authors.lastname: Kermer
authors.forename: I
authors.initials: I
authors.lastname: Sulzbacher
authors.forename: P
authors.initials: P
authors.lastname: Angelberger
authors.forename: K
authors.initials: K
authors.lastname: Kletter
authors.forename: R
authors.initials: R
authors.lastname: Dudczak
authors.forename: R
authors.initials: R
authors.lastname: Ewers
authors.forename: A
authors.initials: A
authors.lastname: Becherer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015224:Dideoxynucleosides; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D011446:Prospective Studies; D011868:Radioisotopes / Q000493:pharmacokinetics; D016019:Survival Analysis
chemical_list: D015224:Dideoxynucleosides; D005462:Fluorine Radioisotopes; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; C002854:alovudine