title: Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.
abstract: The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.
authors.affiliation: University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA.
authors.forename: Ted
authors.initials: T
authors.lastname: Abel
authors.forename: Peter V
authors.initials: PV
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D008568:Memory / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D017868:Cyclic AMP-Dependent Protein Kinases