title: Direct compression properties of chitin and chitosan.
abstract: Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan were found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with the other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications.
authors.affiliation: Institute of Pharmacy and Food, University of Havana, Cuba.
authors.forename: Viviana García
authors.initials: VG
authors.lastname: Mir
authors.forename: Jyrki
authors.initials: J
authors.lastname: Heinämäki
authors.forename: Osmo
authors.initials: O
authors.lastname: Antikainen
authors.forename: Ofelia Bilbao
authors.initials: OB
authors.lastname: Revoredo
authors.forename: Antonio Iraizoz
authors.initials: AI
authors.lastname: Colarte
authors.forename: Olga Maria
authors.initials: OM
authors.lastname: Nieto
authors.forename: Jouko
authors.initials: J
authors.lastname: Yliruusi
mesh_terms: D000465:Algorithms; D000818:Animals; D002482:Cellulose; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002686:Chitin / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D005079:Excipients; D008855:Microscopy, Electron, Scanning; D008121:Nephropidae / Q000737:chemistry; D012212:Rheology
chemical_list: D005079:Excipients; D002686:Chitin; D002482:Cellulose; D048271:Chitosan; C109691:microcrystalline cellulose