title: Holoprosencephaly in Ibadan, Nigeria: a report of three cases and review of literature.
abstract: Holoprosencephaly is a rare congenital malformation resulting from failure of cleavage of midline structures of the forebrain and face. It affects 0.49-1.2 in 10,000 births around the world. The nature of this condition in African children is not well documented in literature. We present a cluster of three cases of holoprosencephaly with varying degrees of facial and intracranial malformations seen within a 6 month period at the University College Hospital, Ibadan, Nigeria.
authors.affiliation: Department of Paediatrics, College of Medicine, University of Ibadan/University College Hospital, Ibadan, Nigeria. ktongo2@yahoo.com
authors.forename: O O
authors.initials: OO
authors.lastname: Tongo
authors.forename: I A
authors.initials: IA
authors.lastname: Lagunju
authors.forename: G O
authors.initials: GO
authors.lastname: Ogun
authors.forename: Z O
authors.initials: ZO
authors.lastname: Imam
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D016142:Holoprosencephaly / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy