Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency.
We studied the effect of Mg-L-aspartate, MgCL2, and their combinations with vitamin B6, magneB6, and MgSO4 on seizure threshold in rats with dietary Mg2+ deficiency. Mg2+ deficiency was followed by a decrease in the threshold dose of corazol (from 79.20 to 49.48 mg/kg), shortening of the latency of the first jerk (by 33.6%, p=0.012), and reduction of the time to the first episode of clonic seizures (by 32.6%, p=0.011). Seizure threshold and latencies of the first jerk and first episode of clonic seizures increased over 3 weeks after peroral administration of Mg2+ salts. The combination of Mg2+ salts and pyridoxine was most effective in this respect.
Spasov
A A
AA
Institute of Pharmacology, Department of Pharmacology, Volgograd State Medical University. farm@vlpost.ru
Iezhitsa
I N
IN
Kharitonova
M V
MV
Kravchenko
M S
MS
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology; D001224:Aspartic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D015636:Magnesium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D008275:Magnesium Deficiency / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D011736:Pyridoxine / Q000008:administration & dosage; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
D000927:Anticonvulsants; D015636:Magnesium Chloride; D001224:Aspartic Acid; D011736:Pyridoxine; D010433:Pentylenetetrazole