Current developments in the molecular genetics of the polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is most likely a complex trait with an oligogenic basis. In this article, we present evidence from molecular genetic studies for involvement of the steroid synthesis gene CYP11a (coding for P450 cholesterol side-chain cleavage) in the aetiology of hyperandrogenism. Variation in the regulatory region of the insulin gene also appears to contribute to the development of PCOS.
Franks
S
S
Department of Obstetrics and Gynaecology, Imperial College School of Medicine, St Mary's Hospital, London, UK.
Gharani
N
N
Waterworth
D
D
Batty
S
S
White
D
D
Williamson
R
R
McCarthy
M
M