[Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion].
OBJECTIVE
To test the effect of Tanshinone II A nanoparticles on the expression of MMP-2.


METHODS
Thirty five male New Zealand white rabbits were randomly divided into three groups. In group A (15 rabbits), the carotid arteries of the rabbits were stripped. In group B (5 rabbits) and C (15 rabbits), nanoparticles and Tanshinone II A nanoparticles were perfused respectively in the denudated arteries of the rabbits. The neointimal areas and the IOD values of MMP-2 secretion were measured.


RESULTS
A significant reduction of neointimal hyperplasia in group C was found compared to the other two groups in terms of the intimal area and the intima-media ratio. Group C had significant lower IOD values than group A.


CONCLUSIONS
Local administration of nanoparticles with incorporated Tanshinone I A not only inhibits neointimal hyperplasia but also inhibits the expression of MMP-2 in stripped arteries.
Liang
Ling
L
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Wei-Hua
WH
Wu
Rong
R
Xie
Qiang
Q
Xiong
Su-Bin
SB
Li
Bin
B
Zeng
Zhia
Z
D045784:Abietanes; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006965:Hyperplasia / Q000378:metabolism; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D053758:Nanoparticles; D010616:Phenanthrenes / Q000494:pharmacology*; D011817:Rabbits
D045784:Abietanes; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C021751:tanshinone; D020778:Matrix Metalloproteinase 2