The Emerging Picture of Human Breast Cancer as a Stem Cell-based Disease.
There are increasing data supporting the existence of a cell hierarchy within the mammary gland. At the top or this hierarchy a small population of cells with self-renewal properties maintains the tissue architecture and remodeling, and they are known as stem cells. Also, recent evidences indicate that breast cancer is originated and maintained by its own cancer stem cells reminding the normal mammary gland. The existence of this small population of cells with self-renewal capability has important biological and clinical significances. So, the interpretation of tumors as hierarchical cellular structures has changed our vision of the breast cancer scenario. Here, we review the current knowledge about normal and breast cancer stem cells, and their implications in cancer development, together with their consequences in breast cancer susceptibility, dissemination and treatment response.
Cobaleda
César
C
Universidad de Salamanca, Salamanca, Spain.
Cruz
Juan Jesús
JJ
González-Sarmiento
Rogelio
R
Sánchez-García
Isidro
I
Pérez-Losada
Jesús
J
D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008321:Mammary Glands, Animal / Q000473:pathology; D042361:Mammary Glands, Human / Q000473:pathology*; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000473:pathology; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000473:pathology; D013234:Stem Cells / Q000473:pathology*; D051153:Wnt Proteins / Q000235:genetics
D051153:Wnt Proteins