title: Long-term clinical evaluation of mitral valve replacement with porcine bioprosthetic valves in dogs.
abstract: This study evaluated the long-term clinical performance of newly developed porcine bioprosthetic valves cross-linked with glutaraldehyde and polyepoxy compound for mitral valve replacement (MVR) in dogs. Five beagle dogs underwent MVR using the porcine bioprosthetic valves during cardiopulmonary bypass. Antithrombotic drugs were administered only for one month after MVR. Six months after MVR, transvalvular regurgitation was not observed in all dogs, paravalvular leakage was seen only in one dog. Twelve months after MVR, mild transvalvular regurgitations were observed in two dogs. Although diastolic atrioventricular pressure gradient was increased gradually, no significant differences were observed. Pressure half-time and valve area were within normal ranges as the bioprosthetic value. There was no clinical symptom of the thrombosis and the thrombogenesis was not observed in the porcine bioprosthetic valve and the annulus in all dogs for twelve months after MVR. The clinical findings suggest that antithrombogenicity of the valves were maintained, though the duability might not be enough in the long-term period.
authors.affiliation: Animal Clinical Research Foundation, Kurayoshi, Tottori, Japan. takashima@ncn-k.net
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Takashima
authors.forename: Aiko
authors.initials: A
authors.lastname: Soda
authors.forename: Ryou
authors.initials: R
authors.lastname: Tanaka
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamane
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001705:Bioprosthesis / Q000662:veterinary*; D001794:Blood Pressure; D004285:Dogs / Q000601:surgery*; D004452:Echocardiography; D004562:Electrocardiography; D004852:Epoxy Compounds; D005976:Glutaral; D008943:Mitral Valve / Q000601:surgery*
chemical_list: D004852:Epoxy Compounds; D005976:Glutaral