Polyomavirus in renal transplantation: a hot problem.
Polyomavirus BK has emerged as an important complication after kidney transplantation. Although, BK nephropathy develops in only 1% to 5% of renal transplant recipients, its prognosis when present is very poor. The most accepted risk factor is the level of immunosuppressive treatment, but the serostatus of donor and recipient and the absence of human leukocyte antigen C7 in donor and/or recipient influence the BK virus (BKV) reactivation. The gold standard in diagnosing BKV nephropathy (BKVN) continues to be biopsy with use of immunohistochemistry for large T antigens. Urinary decoy cells and blood BKV DNA polymerase chain reaction are used in the screening, but their positive predictive values are poor. However, their use as predictors of the evolution of BKVN is more valuable. The reduction of immunosuppressive therapy currently represents the first-line treatment for BKVN. Cidofovir and leflunomide can be used when BKVN continues to progress. In the event of graft loss, retransplantation is possible with a low risk of recurrence when the infection is no longer active.
Bonvoisin
Catherine
C
Department of Nephrology and Renal Transplantation, University Hospitals Liege, Belgium. catherine.bonvoisin@chu.ulg.ac.be
Weekers
Laurent
L
Xhignesse
Patricia
P
Grosch
Stéphanie
S
Milicevic
Miroslav
M
Krzesinski
Jean-Marie
JM
D001739:BK Virus / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology; D007668:Kidney / Q000473:pathology / Q000821:virology; D016030:Kidney Transplantation / Q000276:immunology*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology*; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000276:immunology; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000276:immunology
D007166:Immunosuppressive Agents