title: [Association of PAI-1 gene polymorphism with prognosis of coronary artery disease].
abstract: OBJECTIVE
  To investigate the association of the 4G/5G polymorphism located in the promoter region of plasminogen activator inhibitor-1(PAI-1) gene with prognosis of coronary artery disease (CAD) in Chinese Hans.
  
  
  METHODS
  One hundred and fifty five patients with CAD and 190 unrelated healthy control individuals were included in the study. The 4G/5G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A follow-up survey of major adverse cardiovascular event (MACE) and analysis of the relationship between the severity of coronary vessels and PAI-1 gene polymorphism were carried out.
  
  
  RESULTS
  (1) The frequency of 4G/4G genotype of PAI-1 gene was higher in CAD patients than in controls (58/155, 37.42% vs 52/190, 27.37%, P< 0.01). (2) The frequency of 4G/4G genotype of PAI-1 in patients with MACE was higher than that in patients without MACE (40/81, 49.38% vs 18/74, 23.42%; P< 0.01). (3) The frequency of 4G/4G genotype in patients with multivessel disease was higher than that in patients with single-vessel disease (30/47, 44.77% vs 9/37, 24.32%; P< 0.05).
  
  
  CONCLUSIONS
  The 4G/5G polymorphism located in the promoter region of PAI-1 gene was associated with prognosis of CAD patients, and may be regarded as a biomarker of the severity of the involved vessels.
authors.affiliation: Department of Cardiology, Weifang People's Hospital, Weifang, Shandong, 261041 P. R. China. zhangaiyuan@yahoo.com.cn
authors.forename: Ai-yuan
authors.initials: AY
authors.lastname: Zhang
authors.forename: Xiang-wu
authors.initials: XW
authors.lastname: Ji
authors.forename: Li-xue
authors.initials: LX
authors.lastname: Guan
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D017395:Plasminogen Activator Inhibitor 1