Antibody markers for type 1 diabetes: the issues.
The detection of islet-cell-specific autoantibodies before clinical onset may mean that diabetes mellitus can be predicted, with important implications for targeting those to whom preventive treatment might be given. A large number of such markers have been proposed, but only high-titer islet cell antibodies have so far demonstrated the specificity and sensitivity to be of potential clinical value.
Wilkin
T J
TJ
Endocrine Section (Medicine 11, Level D, South Block) of Southampton General Hospital, Southampton, UK.