title: Feasibility of induction heating using a sintered MgFe2O4 needle for minimally invasive breast cancer therapy.
abstract: BACKGROUND
  This study investigated a novel approach for tumor ablation therapy using an alternating magnetic field combined with a sintered MgFe2O4 needle. This method differs from radiofrequency ablation (RFA) by dielectric heating with regard to the heating mechanism and improves some weak points of these conventional thermotherapies.
  
  
  METHODS
  Nude mice mimicking human breast cancer BT474 were treated using this method. The extent of tumor death was assessed after ablation.
  
  
  RESULTS
  Staining with hematoxylin and eosin showed gradual expansion of the pyknotic area until 48 h after ablation. Nicotinamide adenine dinucleotide diaphorase staining also showed complete tumor death by 48 h after treatment. The ablation area was well controlled and reablation was not necessary. The tumor could be completely controlled using this method without any risk of skin burn.
  
  
  CONCLUSIONS
  This novel ablation therapy appeared to be more effective and less invasive for treatment of breast cancer treatment than RFA.
authors.affiliation: Department of Organ Regenerative Surgery, Ehime University Shitsukawa, Toon-shi, Ehime, Japan. onsen@m.ehime-u.ac.jp
authors.forename: Shungo
authors.initials: S
authors.lastname: Yukumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Horiuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Doi
authors.forename: Kohichi
authors.initials: K
authors.lastname: Sato
authors.forename: Motohira
authors.initials: M
authors.lastname: Yoshida
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Maehara
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Aono
authors.forename: Takashi
authors.initials: T
authors.lastname: Naohara
authors.forename: Kanji
authors.initials: K
authors.lastname: Kawachi
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000601:surgery*; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D045744:Cell Line, Tumor; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods; D008277:Magnesium Oxide; D051379:Mice; D008819:Mice, Nude; D009339:Needles; D023041:Xenograft Model Antitumor Assays
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D008277:Magnesium Oxide; D008058:Dihydrolipoamide Dehydrogenase