The common D302H variant of CASP8 is associated with risk of glioma.
Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.
Bethke
Lara
L
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Sullivan
Kate
K
Webb
Emily
E
Murray
Anne
A
Schoemaker
Minouk
M
Auvinen
Anssi
A
Kiuru
Anne
A
Salminen
Tiina
T
Johansen
Christoffer
C
Christensen
Helle Collatz
HC
Muir
Kenneth
K
McKinney
Patricia
P
Hepworth
Sarah
S
Dimitropoulou
Polyxeni
P
Lophatananon
Artitaya
A
Feychting
Maria
M
Lönn
Stefan
S
Ahlbom
Anders
A
Malmer
Beatrice
B
Henriksson
Roger
R
Swerdlow
Anthony
A
Houlston
Richard
R
D000328:Adult; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D005260:Female; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D053181:Caspase 8