No pathogenic rearrangement within the DISC 1 gene in psychosis.
A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR-based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement.
Legallic
Solenn
S
INSERM U, IFRMP, Rouen, France.
Bou
Jacqueline
J
Haouzir
Sadeq
S
Allio
Gabrielle
G
Demily
Caroline
C
Petit
Michel
M
Frebourg
Thierry
T
Thibaut
Florence
F
Campion
Dominique
D
D001483:Base Sequence; D017931:DNA Primers; D015321:Gene Rearrangement; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics*; D014178:Translocation, Genetic
C412476:DISC1 protein, human; D017931:DNA Primers; D009419:Nerve Tissue Proteins