Seroprevalence and risk factors for human herpesvirus 8 infection, rural Egypt.
To determine whether human herpesvirus 8 (HHV-8) is associated with schistosomal and hepatitis C virus infections in Egypt, we surveyed 965 rural household participants who had been tested for HHV-8 and schistosomal infection (seroprevalence 14.2% and 68.6%, respectively, among those <15 years of age, and 24.2% and 72.8%, respectively, among those > or =15 years of age). Among adults, HHV-8 seropositivity was associated with higher age, lower education, dental treatment, tattoos, > or =10 lifetime injections, and hepatitis C virus seropositivity. In adjusted analyses, HHV-8 seropositivity was associated with dental treatment among men (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.1-5.2) and hepatitis C virus seropositivity among women (OR 3.3, 95% CI 1.4-7.9). HHV-8 association with antischistosomal antibodies was not significant for men (OR 2.1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% CI 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt.
Mbulaiteye
Sam M
SM
National Cancer Institute, Bethesda, MD, USA. mbulaits@mail.nih.gov
Pfeiffer
Ruth M
RM
Dolan
Bryan
B
Tsang
Victor C W
VC
Noh
John
J
Mikhail
Nabiel N H
NN
Abdel-Hamid
Mohamed
M
Hashem
Mohamed
M
Whitby
Denise
D
Thomas Strickland
G
G
Goedert
James J
JJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006566:Herpesviridae Infections / Q000097:blood / Q000453:epidemiology*; D019288:Herpesvirus 8, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012424:Rural Population; D012547:Schistosoma / Q000276:immunology; D012552:Schistosomiasis / Q000097:blood / Q000453:epidemiology*; D016036:Seroepidemiologic Studies; D012727:Sex Characteristics
D000909:Antibodies, Helminth; D000914:Antibodies, Viral