title: Bacteria subsisting on antibiotics.
abstract: Antibiotics are a crucial line of defense against bacterial infections. Nevertheless, several antibiotics are natural products of microorganisms that have as yet poorly appreciated ecological roles in the wider environment. We isolated hundreds of soil bacteria with the capacity to grow on antibiotics as a sole carbon source. Of 18 antibiotics tested, representing eight major classes of natural and synthetic origin, 13 to 17 supported the growth of clonal bacteria from each of 11 diverse soils. Bacteria subsisting on antibiotics are surprisingly phylogenetically diverse, and many are closely related to human pathogens. Furthermore, each antibiotic-consuming isolate was resistant to multiple antibiotics at clinically relevant concentrations. This phenomenon suggests that this unappreciated reservoir of antibiotic-resistance determinants can contribute to the increasing levels of multiple antibiotic resistance in pathogenic bacteria.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Gautam
authors.initials: G
authors.lastname: Dantas
authors.forename: Morten O A
authors.initials: MO
authors.lastname: Sommer
authors.forename: Rantimi D
authors.initials: RD
authors.lastname: Oluwasegun
authors.forename: George M
authors.initials: GM
authors.lastname: Church
mesh_terms: D039903:Actinobacteria / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D041963:Bacteroidetes / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D002228:Carbenicillin / Q000378:metabolism; D002939:Ciprofloxacin / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D008969:Molecular Sequence Data; D010406:Penicillins / Q000378:metabolism; D010802:Phylogeny; D020560:Proteobacteria / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D012988:Soil Microbiology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D002939:Ciprofloxacin; D002228:Carbenicillin