title: Disturbance of automatic auditory change detection in dementia associated with Parkinson's disease: A mismatch negativity study.
abstract: OBJECTIVE
  To investigate whether automatic auditory change detection, as measured by the mismatch negativity (MMN) event-related potential waveform, differs in dementia associated with Parkinson's disease (PDD) and dementia with Lewy-bodies (DLB) as compared to Alzheimer's disease (AD), Parkinson's disease without dementia (PD) and healthy control subjects (HC).
  
  
  METHODS
  Seventeen DLB, 15 PDD, 16 PD, 16 AD patients and 18 HC subjects participated. A passive MMN event-related potential paradigm and an oddball-distractor reaction time paradigm were presented.
  
  
  RESULTS
  The PDD patients had reduced MMN area and amplitude compared to the DLB, PD, and the HC groups. The MMN area correlated significantly with number of missed target stimuli in the oddball-distractor task, and the PDD group missed targets significantly more often than the DLB group.
  
  
  CONCLUSIONS
  The results indicate that PDD patients to a larger degree than patients with DLB have a deficit of automatic auditory change detection that contributes to impairment in their ability to selectively attend and respond to deviant auditory stimuli.
authors.affiliation: Norwegian Centre for Movement Disorders, Stavanger University Hospital, P. Box 8100, 4068 Helse Stavanger, Norway. bronnick@gmail.com
authors.forename: Kolbjørn S
authors.initials: KS
authors.lastname: Brønnick
authors.forename: Helge
authors.initials: H
authors.lastname: Nordby
authors.forename: Jan Petter
authors.initials: JP
authors.lastname: Larsen
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology; D001288:Attention / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D015331:Cohort Studies; D003704:Dementia / Q000209:etiology / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006313:Hearing Loss, Central / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications / Q000503:physiopathology; D008297:Male; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011237:Predictive Value of Tests