title: Neurologically presenting Whipple disease: case report and review of the literature.
abstract: A previously healthy male with subacute onset right leg weakness was suspected to have an astrocytoma as imaging showed a lesion. Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple disease as a possible diagnosis.
authors.affiliation: Cardiff University, University Hospital of Wales, Heath Park, Cardiff, UK. bucklemj@cardiff.ac.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: Buckle
authors.forename: R W
authors.initials: RW
authors.lastname: Ellis
authors.forename: M
authors.initials: M
authors.lastname: Bone
authors.forename: H
authors.initials: H
authors.lastname: Lockman
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004386:Duodenum; D005487:Foam Cells / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D012008:Recurrence; D013122:Spinal Diseases / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D054851:Tropheryma / Q000302:isolation & purification; D008061:Whipple Disease / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination