title: [A case of small cell lung carcinoma complicated by Lambert-Eaton myasthenic syndrome].
abstract: A 54-year old man was admitted with general fatigue, muscle weakness and dyspnea on effort. Medical examinations led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS). Marked improvement of SCLC and symptoms of LEMS were recognized twice during chemoradiotherapy. On his third admission, he showed muscle weakness, dysaethesia, and neurodysfunction of the bladder and rectum. We initially considered these symptoms to be due to spinal metastasis because MRI findings showed multiple spinal metastases. However, electoromyogram and nerve conduction study demonstrated that his muscle weakness resulted from LEMS though dysethesia and neurodysfunction of bladder and rectum were caused by spinal metastasis. We believe that it is important to perform electomyogram and nerve conduction studies, not only radiographic findings, to detect the "hidden" symptoms of LEMS.
authors.affiliation: Department of Respiratory Medicine, Gunma University School of Medicine.
authors.forename: Zen
authors.initials: Z
authors.lastname: Isobe
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suga
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Katou
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Hara
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Aoki
authors.forename: Kana
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Manabu
authors.initials: M
authors.lastname: Ueno
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Maeno
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D018288:Carcinoma, Small Cell / Q000150:complications*; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged