Hematopoietic stem cells in transit--where's the niche?
In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Egr1 targets may lead to better strategies to expand populations of HSCs ex vivo for therapeutic applications.
Magnusson
Mattias
M
Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mikkola
Hanna K A
HK
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D051766:Early Growth Response Protein 1 / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans
C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; C486109:Egr1 protein, mouse