title: As the world grows: contraception in the 21st century.
abstract: Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Most available methods use hormonal steroids or are variations of barrier methods. Reports from several fora over the last 12 years have emphasized the number of unwanted pregnancies and resultant abortions, which indicate an unmet need for safe, acceptable, and inexpensive contraceptive methods. This unmet need can be assuaged, in part, by development of new nonhormonal contraceptive methods. This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development.
authors.affiliation: Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Callaghan, New South Wales, Australia.
authors.forename: R John
authors.initials: RJ
authors.lastname: Aitken
authors.forename: Mark A
authors.initials: MA
authors.lastname: Baker
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Doncel
authors.forename: Martin M
authors.initials: MM
authors.lastname: Matzuk
authors.forename: Christine K
authors.initials: CK
authors.lastname: Mauck
authors.forename: Michael J K
authors.initials: MJ
authors.lastname: Harper
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003267:Contraception; D006801:Humans; D007246:Infertility; D010641:Phenotype; D011153:Population