title: Synthesis and antimicrobial activities of a new series of 4-S-[4(1)-amino-5(1)-oxo-6(1)-substituted benzyl-4(1),5(1)-dihydro-1(1),2(1),4(1)-triazin-3-yl]mercaptoacetyl-3-arylsydnones.
abstract: The synthesis of some 4-S-(4(1)-amino-5(1)-oxo-6(1)-substituted benzyl-4(1),5(1)-dihydro-1(1),2(1),4(1)-triazin-3-yl)mercaptoacetyl-3-arylsydnones by the reaction of 3-aryl-4-bromoacetylsydnones with 6-substituted-4-amino-3-mercapto-1,2,4-triazin-5-ones is described. The IR, (1)H NMR, mass spectra and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were screened for their antimicrobial activity. All the compounds showed higher activity than that of standard drug during antimicrobial studies and the activity was comparable with the standard drug for antifungal activity.
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574 199, Karnataka, India.
authors.forename: Jyothi C
authors.initials: JC
authors.lastname: Hegde
authors.forename: K S
authors.initials: KS
authors.lastname: Girisha
authors.forename: Adithya
authors.initials: A
authors.lastname: Adhikari
authors.forename: Balakrishna
authors.initials: B
authors.lastname: Kalluraya
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013558:Sydnones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013558:Sydnones