title: Multifocal glioblastoma multiforme with synchronous spontaneous hemorrhage: case report.
abstract: We report a 65 year old man who presented with left hemiparesis, and was found to have multiple, discrete, peripherally enhancing, hemorrhagic intra-axial masses in the right hemisphere of the brain. Workup for malignancy elsewhere in the body was negative, and biopsy confirmed glioblastoma multiforme. The patient responded clinically to treatment with radiation therapy and temozolomide. We discuss the unusual aspects of this case and stress the importance of tissue diagnosis in managing suspected intracranial malignancies.
authors.affiliation: Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA. RBenveniste@med.miami.edu
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Benveniste
authors.forename: Glen
authors.initials: G
authors.lastname: Manzano
authors.forename: Carol K
authors.initials: CK
authors.lastname: Petito
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001706:Biopsy; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D054022:Cerebrum / Q000000981:diagnostic imaging / Q000473:pathology*; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D005909:Glioblastoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D010291:Paresis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D011878:Radiotherapy; D000077204:Temozolomide; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D003606:Dacarbazine; D000077204:Temozolomide