A heterogeneous-catalyst-based, microwave-assisted protocol for the synthesis of 2,2'-bipyridines.
A new method of preparing 2,2'-bipyridines with short reaction times by using microwave assistance and heterogeneous catalysts has been developed. With a Negishi-like protocol, it was found that Ni/Al(2)O(3)-SiO(2) afforded 2,2'-bipyridine products in up to 86% yield in 1 h. Palladium supported on alumina also provided yields of 2,2'-bipyridines comparable to those seen for homogeneous PEPPSI (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II)dichloride) and tetrakis(triphenylphosphanyl)palladium complexes.
Moore
Lucas R
LR
Department of Chemistry, University of Hawaii, 2545 McCarthy Mall, Honolulu, HI 96822, USA.
Vicic
David A
DA
D015082:2,2'-Dipyridyl / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D003432:Cross-Linking Reagents; D007477:Ions; D015082:2,2'-Dipyridyl; D010165:Palladium