Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity.
Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
Sater
Ali A Abdul
AA
School of Natural Sciences, University of California, Merced, California 95344, USA.
Ojcius
David M
DM
Meyer
Matthew P
MP
D000282:Administration, Intravaginal; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002690:Chlamydia Infections / Q000188:drug therapy / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D024881:Drug Resistance, Bacterial; D005079:Excipients / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D014623:Vaginal Diseases / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D005079:Excipients; D002482:Cellulose; C002283:hydroxyethylcellulose