title: Clinical outcome in patients with peripheral artery disease. Results from a prospective registry (FRENA).
abstract: BACKGROUND
  The risk of future cardiovascular events in patients with peripheral artery disease (PAD) is often underestimated.
  
  
  METHODS
  FRENA is an ongoing, observational registry of consecutive outpatients with symptomatic PAD, coronary artery disease (CAD) or cerebrovascular disease (CVD). We compared the incidence of major cardiovascular events (i.e., myocardial infarction, ischemic stroke, critical limb ischemia, or cardiovascular death) during a 12-month follow-up period in a series of consecutive outpatients with PAD, CAD or CVD.
  
  
  RESULTS
  As of December 2006, 1265 patients had been enrolled in FRENA who completed the 12-month follow-up. Of these, 417 patients (33%) had PAD, 474 (37%) had CAD, 374 (30%) had CVD. Patients with PAD had an increased incidence of major cardiovascular events per 100 patient-years: 17 (95% CI: 13-22) vs. 7.9 (5.5-11) in those with CAD, or 8.9 (6.1-13) in those with CVD. Compared to patients with CAD or CVD those with PAD had a similar incidence of myocardial infarction or stroke, but a higher incidence of critical limb ischemia, limb amputation and death. This incidence increased with the severity of the symptoms: 8.7 (95% CI: 5.3-13) in patients in Fontaine stage IIa; 25 (95% CI: 16-38) in stage IIb; 26 (95% CI: 13-47) in stage III; 42 (95% CI: 24-67) in stage IV.
  
  
  CONCLUSIONS
  Our data confirm a higher incidence of major cardiovascular events for patients with PAD, as well as a correlation of these events with the severity of PAD.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. mmonreal.germanstrias@gencat.net
authors.forename: Manuel
authors.initials: M
authors.lastname: Monreal
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Alvarez
authors.forename: Blanca
authors.initials: B
authors.lastname: Vilaseca
authors.forename: Ramón
authors.initials: R
authors.lastname: Coll
authors.forename: Carmen
authors.initials: C
authors.lastname: Suárez
authors.forename: Jesús
authors.initials: J
authors.lastname: Toril
authors.forename: Carmen
authors.initials: C
authors.lastname: Sanclemente
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005121:Extremities / Q000098:blood supply; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D016491:Peripheral Vascular Diseases / Q000453:epidemiology*; D012042:Registries; D012307:Risk Factors; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology