title: Perinatal factors associated with the neurologic impairment of children born preterm.
abstract: OBJECTIVE
  To determine the perinatal risk factors of long-term neurologic impairment for preterm infants.
  
  
  METHODS
  A case-control study was conducted with 60 neurologically impaired and 60 healthy children, all born prematurely.
  
  
  RESULTS
  There was no relation between neurologic impairment and maternal pregnancy complications or prenatal steroid administration, bacteriologic content of cervical smear, fetal presentation, fetal heart rate, or mode of delivery. Cerebral palsy was associated with early neurologic signs, perinatal asphyxia, neonatal septicemia, abnormal brain ultrasound findings, prolonged interval between rupture of membranes and delivery, and multiple placental lesions. Children with minimal cerebral dysfunction were more frequently first born. Multiple placental lesions, neonatal septicemia, abnormal brain ultrasound findings, and perinatal asphyxia were independently correlated with long-term neurologic impairment.
  
  
  CONCLUSIONS
  Perinatal infection, perinatal asphyxia, and abnormal brain ultrasound findings seem to be risk factors for cerebral palsy whereas primigravidity seems to be correlated with minimal cerebral dysfunction.
authors.affiliation: Department of Perinatal Medicine, School of Medicine, University of Zagreb, Croatia. vladimir.banovic2@zg.htnet.hr
authors.forename: Snjezana
authors.initials: S
authors.lastname: Skrablin
authors.forename: Ivana
authors.initials: I
authors.lastname: Maurac
authors.forename: Vladimir
authors.initials: V
authors.lastname: Banović
authors.forename: Katarina
authors.initials: K
authors.lastname: Bosnjak-Nadj
mesh_terms: D001238:Asphyxia Neonatorum / Q000453:epidemiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology*; D001925:Brain Damage, Chronic / Q000453:epidemiology*; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D017523:Croatia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000453:epidemiology; D008297:Male; D008423:Maternal Age; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome; D012307:Risk Factors