Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus).
Under the bioassay-guided method, two diterpenes, 3-O-(2",3"-dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2",3"-dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 microg per cotton ball and still displayed antinematodal activity at a dose of 2.5 microg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D- and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.
Shi
Jianxiao
J
Graduate School of Natural Science and Technology, Department of Applied Bioscience and Biotechnology, Laboratory of Natural Products Chemistry, Faculty of Agriculture, Okayama University, Tsushima naka 3-1-1, Okayama 700-8530, Japan.
Li
Zhixuan
Z
Nitoda
Teruhiko
T
Izumi
Minoru
M
Kanzakia
Hiroshi
H
Baba
Naomichi
N
Kawazu
Kazuyoshi
K
Nakajima
Shuhei
S
D000818:Animals; D000969:Antinematodal Agents / Q000633:toxicity*; D004224:Diterpenes / Q000302:isolation & purification / Q000633:toxicity*; D028481:Euphorbia / Q000737:chemistry*; D008958:Models, Molecular; D009348:Nematoda / Q000187:drug effects*; D028223:Pinus / Q000469:parasitology; D018517:Plant Roots / Q000737:chemistry*; D014934:Wood / Q000469:parasitology*
D000969:Antinematodal Agents; D004224:Diterpenes