Malignancy: an unrecognized risk factor for coronary stent thrombosis?
Stent thrombosis is a potentially catastrophic complication of coronary artery stenting. There have been particular concerns about the incidence of stent thrombosis following insertion of drug-eluting stents. We report a series of cases in which stent thrombosis occurred in association with malignancy and describe the potential mechanisms behind such an association. We speculate that this association merits further investigation as it raises the possibility that known malignancy may be a risk factor for stent thrombosis and that unexplained stent thrombosis, particularly if recurrent, should stimulate a search for occult malignancy.
Hobson
Alex R
AR
Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Southampton S016 6YD, United Kingdom.
McKenzie
Daniel B
DB
Kunadian
Vijayalakshmi
V
Purcell
Ian
I
Zaman
Azfar
A
Dawkins
Keith D
KD
Curzen
Nick
N
D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000627:therapeutic use; D023903:Coronary Restenosis / Q000209:etiology*; D003328:Coronary Thrombosis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis*; D009382:Neoplasms, Unknown Primary / Q000150:complications / Q000175:diagnosis; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D015607:Stents
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors