Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis.
We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.
Stamm
Bernhard
B
Kantonsspital Aarau, Aarau, Switzerland. stamm@ksa.ch
Moschopulos
Michael
M
Hungerbuehler
Hansjoerg
H
Guarner
Jeannette
J
Genrich
Gillian L
GL
Zaki
Sherif R
SR
D000208:Acute Disease; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D000942:Antigens, Bacterial / Q000302:isolation & purification; D001921:Brain / Q000382:microbiology / Q000473:pathology; D004679:Encephalomyelitis / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009177:Mycoplasma pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000150:complications*; D011129:Polyradiculoneuropathy / Q000150:complications / Q000382:microbiology* / Q000473:pathology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial