title: Assessment of plasma antioxidant status in hemodialysis patients.
abstract: The risk of atherosclerosis and cancer is high in patients on hemodialysis. A breakdown in the natural balance between the activity of the body's antioxidant system and the production of oxidizing agents is suggested to be involved. To investigate the oxidative stress status in Iranian hemodialytic patients, in this study we evaluated plasma vitamin E, malondialdehyde (MDA), reduced glutathione (GSH), and ferric reducing antioxidant power (FRAP) levels in these patients. Twenty-four hemodialytic patients and 24 control subjects (age and sex matched) were included in this study. Each patient was under dialysis, three times per week, four hours in each session. Before and after dialysis, blood was taken for biochemical measurements as well as oxidative stress tests. There was a significant decrease in FRAP and GSH levels after dialysis comparing to before treatment levels. MDA was increased by dialysis and vitamin E levels were less in dialytic patients, both before and after treatment, compared to controls. This study indicates that there is a significant level of oxidative stress in chronic renal patients and this stress is augmented by dialysis. Antioxidant therapy could be considered in these patients.
authors.affiliation: Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. kadkhodm@tums.ac.ir
authors.forename: Mehri
authors.initials: M
authors.lastname: Kadkhodaee
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hemmati
authors.forename: Maryam
authors.initials: M
authors.lastname: Zahmatkesh
authors.forename: Rana
authors.initials: R
authors.lastname: Ghaznavi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mirershadi
authors.forename: Mitra
authors.initials: M
authors.lastname: Mahdavi-Mazde
authors.forename: Behjat
authors.initials: B
authors.lastname: Seifi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D006801:Humans; D007492:Iran; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D006435:Renal Dialysis; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D005290:Ferric Compounds; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione