Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue.
Fgf receptor 2c (Fgfr2c) was expressed in mature adipocytes of mouse white adipose tissue (WAT). To examine the role of Fgfr2c in mature adipocytes, we generated adipocyte-specific Fgfr2 knockout (Fgfr2 CKO) mice. The hypertrophy impairment of adipocytes in the mesenteric WAT but not in the subcutaneous WAT and decreased plasma free fatty acid (FFA) levels were observed in Fgfr2 CKO mice. Although the expression of genes involved in adipocyte differentiation and lipid metabolism in the mesenteric WAT was essentially unchanged, the expression of uncoupling protein 2 potentially involved in energy dissipation was significantly increased. Among potential Fgf ligands for Fgfr2c, Fgf9 was preferentially expressed in the mesenteric WAT. The present findings indicate that Fgfr2c potentially activated by Fgf9 plays a role in the adipocyte hypertrophy in the mesenteric WAT and FFA metabolism and/or energy dissipation in the mesenteric WAT might be involved in the hypertrophy impairment.
Konishi
Morichika
M
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida-Shimoadachi, Sakyo, Kyoto 606-8501, Japan.
Nakamura
Hirotoshi
H
Miwa
Hiroyuki
H
Chambon
Pierre
P
Ornitz
David M
DM
Itoh
Nobuyuki
N
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D001692:Biological Transport / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D004734:Energy Metabolism / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D018390:Gene Targeting; D005947:Glucose / Q000378:metabolism; D006984:Hypertrophy; D050356:Lipid Metabolism / Q000187:drug effects; D008643:Mesentery / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D009929:Organ Size / Q000187:drug effects; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics / Q000378:metabolism*; D013629:Tamoxifen / Q000494:pharmacology
D013629:Tamoxifen; C496354:Fgfr2 protein, mouse; D051497:Receptor, Fibroblast Growth Factor, Type 2; D005947:Glucose