From DNA end chemistry to cell-cycle response: the importance of structure, even when it's broken.
In this issue of Molecular Cell, Barlow et al. (2008) show that not all DNA double-strand breaks are processed equally and that the chemical nature of DNA ends guides different paths to DNA repair.
Wyman
Claire
C
Department of Cell Biology and Genetics, Cancer Genomics Center, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Warmerdam
Daniël O
DO
Kanaar
Roland
R
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans; D009690:Nucleic Acid Conformation
D004247:DNA