Effect of Aerodiol administration on ocular arteries in postmenopausal women.
OBJECTIVE
The aim of the present study was to evaluate the alteration of ocular blood hemodynamics after intranasal administration of 17beta-estradiol, through measurement of the ophthalmic artery (OA) and the central retinal artery (CRA) using color duplex sonography.


METHODS
Thirty healthy women who had been naturally postmenopausal for at least 1 year were enrolled in the study. A randomized, placebo-controlled, crossover, double-blinded study was conducted of the acute effect of 17beta-estradiol (Aerodiol; Servier, Chambrayles-Tours, France) on OA and CRA blood flow using color duplex sonography.


RESULTS
The peak systolic and end diastolic velocities of the CRA were increased significantly after 17beta-estradiol administration compared with placebo. A significant decrease was also found in the pulsatility and resistive indices of the CRA. However, there were no statistically significant differences in OA flow velocities or pulsatility and resistive indices.


CONCLUSIONS
Nasal 17beta-estradiol administration in postmenopausal women causes an improvement in the ocular vascular Doppler indices. These results suggest that there could be a positive effect of Aerodiol on middle-sized arteries and arterioles.
Sahin
Figen Kir
FK
Department of Obstetrics and Gynecology, Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey. dr_figenkir@hotmail.com
Koken
Gulengul
G
Cosar
Emine
E
Arioz
Dagistan Tolga
DT
Degirmenci
Bumin
B
Albayrak
Ramazan
R
Acar
Murat
M
D000281:Administration, Intranasal; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000187:drug effects*; D010919:Placebos; D017698:Postmenopause / Q000187:drug effects; D012161:Retinal Artery / Q000187:drug effects*
D010919:Placebos; D004958:Estradiol