Current status of isolated limb infusion with mild hyperthermia for melanoma.
OBJECTIVE
Recurrent disease confined to a limb is a frequently encountered clinical problem in patients with melanoma. Regional chemotherapy by isolated limb perfusion (ILP) provides effective treatment but is invasive, complex and costly. Isolated limb infusion (ILI) is a simple yet effective alternative to ILP.


METHODS
ILI involves drug administration into a limb via percutaneously inserted catheters after vascular isolation of the limb has been achieved with a tourniquet. The infused drug is circulated for 30 minutes via a simple extracorporeal circuit incorporating a heater (to produce mild hyperthermia).


RESULTS
Limb tumour remission rates are similar to those achieved by conventional ILP. ILI is well tolerated, and elderly patients and those with major medical co-morbidities and serious peripheral vascular problems can be treated.


CONCLUSIONS
ILI with mild hyperthermia is an established alternative to hyperthermic ILP for patients with recurrent limb melanoma. It can also be used for patients with soft tissue sarcomas and a variety of serious, chronic dermatological conditions.
Thompson
John F
JF
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. john.thompson@smu.org.au
Kam
Peter C A
PC
D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D003131:Combined Modality Therapy; D005121:Extremities / Q000098:blood supply; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D000970:Antineoplastic Agents