Requirement of lipocalin 2 for chronic myeloid leukemia.
The Bcr-Abl oncoprotein causes chronic myeloid leukemia by a mechanism involving its activated tyrosine kinase. BCR-ABL+ mouse hematopoietic cells persistently express and secrete lipocalin 2 by a mechanism that requires the tyrosine kinase of the Bcr-Abl oncoprotein. Our new findings indicate that lipocalin 2 is required for leukemia induction, as prevention of expression of lipocalin 2 by BCR-ABL+ mouse marrow cells totally blocks leukemia induction in a mouse model.
Arlinghaus
Ralph
R
Department of Molecular Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. rarlingh@mdanderson.org
Leng
Xiaohong
X
D000209:Acute-Phase Proteins / Q000032:analysis / Q000502:physiology*; D000818:Animals; D017209:Apoptosis; D001853:Bone Marrow / Q000473:pathology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D016044:Fusion Proteins, bcr-abl; D006412:Hematopoietic Stem Cells / Q000737:chemistry / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology / Q000473:pathology*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000032:analysis / Q000502:physiology*; D051379:Mice; D016513:Mice, SCID; D015513:Oncogene Proteins / Q000032:analysis / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*
D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; C071332:Lcn2 protein, mouse; D016044:Fusion Proteins, bcr-abl