title: Phenolic constituents from the wood of Morus australis with cytotoxic activity.
abstract: A new methylated flavonol, 5,7,2',4'-tetrahydroxy-3-methoxyflavone (1), had been isolated from the methanol extract of the wood of Morus australis, along with nine known compounds, kuwanon C (2), morusin (3), morachalcone A (4), oxyresveratrol (5), 4'-(2-methyl-2-buten-4-yl)oxyresveratrol (6), moracins M (7) and C (8), alboctalol (9), and macrourin B (10). The structures of these compounds were determined based on spectral evidence, including UV, IR, NMR, and mass spectra. Cytotoxic properties of compounds 1-10 were evaluated against murine leukemia P-388 cells. The prenylated stilbene 6 and 2-arylbenzofuran 8, and morusin (3) were found to have strong cytotoxic effects with IC50 values of 6.9, 8.7, and 10.1 microM, respectively.
authors.affiliation: Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia. euis@chem.itb.ac.id
authors.lastname: Ferlinahayati
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
authors.forename: Lia D
authors.initials: LD
authors.lastname: Juliawaty
authors.forename: Sjamsul A
authors.initials: SA
authors.lastname: Achmad
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
authors.forename: Ikram M
authors.initials: IM
authors.lastname: Said
authors.forename: Jalifah
authors.initials: J
authors.lastname: Latip
mesh_terms: D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D031625:Morus / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D013053:Spectrophotometry; D014934:Wood
chemical_list: D047309:Flavones; D044948:Flavonols; D010636:Phenols; D010936:Plant Extracts