title: Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines.
abstract: An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.
authors.affiliation: Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.
authors.forename: Hexin
authors.initials: H
authors.lastname: Xie
authors.forename: Liansuo
authors.initials: L
authors.lastname: Zu
authors.forename: Hanine R
authors.initials: HR
authors.lastname: Oueis
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D004583:Electrons; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D007659:Ketones; D011724:Pyridazines; D011392:Proline