Possible roles of mast cell-derived chymase for skin rejuvenation.
The relationships between mast cell-derived chymase, angiotensin II, and extracellular matrix production in the skin after intense pulsed light (IPL) were clarified in hamsters. Dorsal areas of the hamsters were irradiated once or twice a week by IPL. The index of extracellular matrix production in the skin was defined as the depth stained with Azan-Mallory stain from the epidermis to the dermis at the point of maximum thickness. The index had significantly increased 7 days after IPL irradiation in sections treated once or twice with IPL compared with that of untreated control sections. The numbers of mast cells, chymase-positive cells, and angiotensin II-positive cells had also significantly increased in IPL-irradiated areas. Significant increases in chymase and angiotensin II activities were observed in the extracts obtained from IPL-irradiated skin. Mast cell-derived chymase may be involved via angiotensin II formation in the dermal extracellular matrix production that occurs after IPL irradiation.
Amano
Nobuyuki
N
Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
Takai
Shinji
S
Jin
Denan
D
Ueda
Koichi
K
Miyazaki
Mizuo
M
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D053818:Chymases / Q000378:metabolism*; D006224:Cricetinae; D005109:Extracellular Matrix / Q000528:radiation effects; D053685:Laser Therapy; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*; D008647:Mesocricetus; D010789:Phototherapy; D012867:Skin / Q000201:enzymology / Q000473:pathology* / Q000528:radiation effects*
D000804:Angiotensin II; D053818:Chymases