[In vitro activity of ertapenem against staphylococci].
Ertapenem is a new carbapenem with an excellent activity against different Gram-negative and Gram-positive bacteria. Its good antibacterial activity is closely related to high hydrolysis resistance by bacterial beta-lactamases.


METHODS
We evaluated antimicrobial activity of ertapenem by comparison that of methicillin, gatifloxacin, cefepime and linezolid against 455 staphylococci collected during 2006-2007 period from healthy individuals.


RESULTS
Minimum inhibitory concentrations were determined by agar dilution technique. Ertapenem has an activity comparable to the other tested agents. Resistance rate was 1% for all investigated strains.
Tuchiluş
Cristina
C
Disciplina Microbiologie, Facultatea de Farmacie, Universitatea de Medicină si Farmacie "Gr.T. Popa", Iaşi.
Goldu
Ioana
I
Poiata
Antonia
A
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests / Q000379:methods; D000077727:Ertapenem; D024841:Fluoroquinolones / Q000494:pharmacology; D000077734:Gatifloxacin; D006801:Humans; D066298:In Vitro Techniques; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D012189:Retrospective Studies; D013211:Staphylococcus aureus / Q000187:drug effects*; D018440:beta-Lactam Resistance / Q000187:drug effects; D047090:beta-Lactams / Q000494:pharmacology*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; D023303:Oxazolidinones; D047090:beta-Lactams; D000077723:Cefepime; D000077727:Ertapenem; D000069349:Linezolid; D000077734:Gatifloxacin; D008712:Methicillin