Calcitonin peptide inhibition of TRH-stimulated prolactin secretion Additional evidence for inhibitory regulation of phospholipase C.
Calcitonin peptides have been reported to exert direct inhibitory effects on stimulated prolactin secretion from lactotrophs. Several studies indicate that calcitonin peptide inhibition is rather selective for the stimulatory effects of thyrotropin-releasing hormone (TRH), but not those of other secretagogues. Recent reports demonstrate inhibitory effects of calcitonin peptides on TRH-induced calcium mobilization and inositol phosphate generation. The possibility is discussed that calcitonin peptides act at pituitary receptors that are coupled to phospholipase C in an inhibitory manner.
Martin
T F
TF
Thomas F.J. Martin is at the Department of Zoology, University of Wisconsin, Madison, WI 53706, USA.