title: Efficacy of aerobic exercise on coronary heart disease risk factors.
abstract: The authors examined the effects of aerobic exercise on selected coronary heart disease (CHD) risk factors using data from previously published meta-analyses. Using a random effects model, the effects of aerobic exercise on glycosylated hemoglobin (HbA1c) (mean, 95% confidence interval, -0.9%, -1.9% to 0.03%), resting systolic blood pressure (-6.9 mm Hg, -9.1 to -4.6 mm Hg), low-density lipoprotein cholesterol (-3.1 mg/dL, -6.1 to 0 mg/dL), and body mass index (-1.3 kg/m(2), -2.5 to -0.1 kg/m(2)) were either statistically significant or demonstrated a trend for statistical significance. Changes were equivalent to relative reductions of -8.5%, -4.7%, -2.0%, and -4.5%, respectively. Changes corresponded to estimated 5-year reductions in CHD mortality of 14%, 17%, 1.5%, and 5%, respectively. The results of this review reinforce the idea that aerobic exercise is an important nonpharmacologic intervention for improving selected CHD risk factors.
authors.affiliation: Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506-9190, USA. gkelley@hsc.wvu.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Kelley
authors.forename: Kristi S
authors.initials: KS
authors.lastname: Kelley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin