Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography.
We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (18F-FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.
Konecky
Soren D
SD
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA. skonecky@physics.upenn.edu
Choe
Regine
R
Corlu
Alper
A
Lee
Kijoon
K
Wiener
Rony
R
Srinivas
Shyam M
SM
Saffer
Janet R
JR
Freifelder
Richard
R
Karp
Joel S
JS
Hajjioui
Nassim
N
Azar
Fred
F
Yodh
Arjun G
AG
D001940:Breast / Q000000981:diagnostic imaging* / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*