title: NF-kappaB regulates prenatal stress-induced cognitive impairment in offspring rats.
abstract: The study was designed to investigate whether nuclear factor of kappa B (NF-kappaB) plays regulating role in prenatal stress-induced cognitive impairment and oxidative damage in offspring rats. The authors used a rat model to study plasma levels of corticosterone and oxidative DNA damage (8-OH-dG), protein expression of P65/p50 NF-kappaB, and cognitive function in female and male offspring rats in middle pregnant stage and later pregnant stage. Prenatal stress affected the capability of learning and memory in the offspring, especially in later stage stressed female offspring. The levels of corticosterone and 8-OH-dG were enhanced in response to stress. Both middle and later stage stresses induced a significant decrease in P65 expression and a significant increase in P50 expression in female offspring. In addition, later stage stress induced a significant decrease in P50 expression in male offspring. These results suggest that NF-kappaB complex may be acting in a positive regulatory fashion in prenatal stress-induced cognitive impairment and that oxidative DNA damage may exacerbate the activation of NF-kappaB.
authors.affiliation: Xi'an Jiaotong University.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Jia
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.forename: Zhuanli
authors.initials: Z
authors.lastname: Bai
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Tianbao
authors.initials: T
authors.lastname: Song
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jiankang
authors.initials: J
authors.lastname: Liu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D001921:Brain / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D018891:Dentate Gyrus / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D004924:Escape Reaction / Q000502:physiology; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D016328:NF-kappa B / Q000378:metabolism; D052002:NF-kappa B p50 Subunit / Q000378:metabolism; D009949:Orientation / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology*; D012737:Sex Factors; D013037:Spatial Behavior / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism*; D050863:Synaptotagmin I / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D050863:Synaptotagmin I; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D003345:Corticosterone