T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis.
T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.
Blauvelt
Andrew
A
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA. blauvela@ohsu.edu
D006801:Humans; D053759:Interleukin-23 / Q000235:genetics* / Q000276:immunology*; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000502:physiology*
D053759:Interleukin-23