Congenital diaphragmatic hernia and retinoids: searching for an etiology.
Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH.
Montedonico
Sandra
S
The Children's Research Centre, Our Lady's Children's Hospital, Dublin 12, Ireland. sandramontedonico@hotmail.com
Nakazawa
Nana
N
Puri
Prem
P
D006548:Hernia, Diaphragmatic / Q000378:metabolism; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D012176:Retinoids / Q000378:metabolism*; D015398:Signal Transduction
D012176:Retinoids