title: Preparation of nonsymmetrically substituted stilbenes in a one-pot two-step heck strategy using ethene as a reagent.
abstract: We present here a strategy for the preparation of nonsymmetrically substituted stilbenes using a one-pot two-step double Heck strategy. First a protocol is developed for the selective preparation of a range of styrenes using ethene as the alkene coupling partner. Then conditions are found for the effective coupling of the styrenes with aryl halides using a 1:1 stoichiometric ratio of the two components. The use of the microwave apparatus to perform the reactions offers a convenient method for synthesis as well as for safely, easily, and accurately loading vessels with gaseous reagents.
authors.affiliation: Department of Chemistry, University of Connecticut, Storrs, CT 06269-3060, USA.
authors.forename: Chad M
authors.initials: CM
authors.lastname: Kormos
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Leadbeater
mesh_terms: D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005030:Ethylenes; D006846:Hydrocarbons, Halogenated; D013267:Stilbenes; D010165:Palladium; C036216:ethylene