Brushed aside and silenced.
Mammalian genomes are highly organized in the 3D space of cell nuclei, but whether this affects gene function is unclear. Three papers now show that spatial relocation of a gene directly affects expression, and surprisingly, that of its neighbors.
Chakalova
Lyubomira
L
Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Fraser
Peter
P
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000378:metabolism; D045584:Chromosome Positioning; D005786:Gene Expression Regulation / Q000502:physiology*; D020868:Gene Silencing; D016678:Genome; D014158:Transcription, Genetic