title: Cytotoxic-antineoplastic derivatives of prenyl-1,2-naphthohydroquinone.
abstract: Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of alpha-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI50 values in the microM-concentration level.
authors.affiliation: Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. amolinar@ucv.cl
authors.forename: Aurora
authors.initials: A
authors.lastname: Molinari
authors.forename: Alfonso
authors.initials: A
authors.lastname: Oliva
authors.forename: Claudia
authors.initials: C
authors.lastname: Ojeda
authors.forename: José M Miguel
authors.initials: JM
authors.lastname: del Corral
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones