title: The effects of anisotropy on the stress analyses of patient-specific abdominal aortic aneurysms.
abstract: The local dilation of the infrarenal abdominal aorta, termed an abdominal aortic aneurysm (AAA), is often times asymptomatic and may eventually result in rupture-an event associated with a significant mortality rate. The estimation of in-vivo stresses within AAAs has been proposed as a useful tool to predict the likelihood of rupture. For the current work, a previously-derived anisotropic relation for the AAA wall was implemented into patient-specific finite element simulations of AAA. There were 35 AAAs simulated in the current work which were broken up into three groups: elective repairs (n = 21), non-ruptured repairs (n = 5), and ruptured repairs (n = 9). Peak stresses and strains were compared using the anisotropic and isotropic constitutive relations. There were significant increases in peak stress when using the anisotropic relationship (p < 0.001), even in the absence of the ILT (p = 0.014). Ruptured AAAs resulted in elevated peak stresses as compared to non-ruptured AAAs when using both the isotropic and anisotropic simulations, however these comparisons did not reach significance (p(ani) = 0.55, p(iso) = 0.73). While neither the isotropic or anisotropic simulations were able to significantly discriminate ruptured vs. non-ruptured AAAs, the lower p-value when using the anisotropic model suggests including it into patient-specific AAAs may help better identify AAAs at high risk.
authors.affiliation: Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Vande Geest
authors.forename: David E
authors.initials: DE
authors.lastname: Schmidt
authors.forename: Michael S
authors.initials: MS
authors.lastname: Sacks
authors.forename: David A
authors.initials: DA
authors.lastname: Vorp
mesh_terms: D016880:Anisotropy; D001012:Aorta, Abdominal / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical; D013718:Tensile Strength