Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging.
Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell, whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in the lungs, spleen, and liver.
Alric
Christophe
C
Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
Taleb
Jacqueline
J
Le Duc
Géraldine
G
Mandon
Céline
C
Billotey
Claire
C
Le Meur-Herland
Alice
A
Brochard
Thierry
T
Vocanson
Francis
F
Janier
Marc
M
Perriat
Pascal
P
Roux
Stéphane
S
Tillement
Olivier
O
D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry* / Q000493:pharmacokinetics; D006046:Gold / Q000737:chemistry* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media; D006046:Gold; D004369:Pentetic Acid; D005682:Gadolinium