[Hypocomplementemic urticarial vasculitis].
Hypocomplementemic urticarial vasculitis is a rare disorder characterized by the presence of C1q precipitins associated with a syndrome of urticarial vasculitis, arthralgias, ocular inflammation and obstructive-lung disease. We report the case of a 48-year-old woman with hypocomplementemic urticarial vasculitis. Because of dependance to corticosteroids, cyclophosphamide-pulse therapy was started and resulted in significant clinical improvement. Mycophenolate mofetil was effective as maintenance therapy and resulted in complete resolution of rash, arthralgias, arthritis and uveitis, but had no effect on the obstructive-lung disease.
Ghadban
R
R
Service de médecine interne, centre hospitalier de Valence, 26953 Valence cedex 9, France.
Zenone
T
T
Leveque-Michaud
C
C
Louerat
C
C
Rousset
H
H
D015922:Complement C1q / Q000172:deficiency*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications; D014657:Vasculitis / Q000097:blood* / Q000188:drug therapy
D015922:Complement C1q; D003520:Cyclophosphamide; D009173:Mycophenolic Acid