title: Evaluation of related with age of IFN-gamma levels of treated leprosy patients and their healthy relatives compared with a control group.
abstract: OBJECTIVE
  This study was to search how change with age of IFN-gamma (IFN-gamma) levels of leprosy patients who had received or still undergoing treatment, their healthy close relatives and healthy people.
  
  
  METHODS
  From a total of 39 patients, 28 had received leprosy treatment and recovered with some defects [17 Lepromatous Leprosy(LL), 7 Borderline Lepromatous (BL), 3 Borderlien Tuberculoid (BT), 1 Tuberculoid form (TT)] and 11 (9 LL, 2 BL) were undergoing therapy in a hospital at that moment. Close relatives of the patients included 39 people living with treated patients in the same house and the control group consisted of 39 healthy people. Human IFN-gamma kits were used as a solid phase sandwich ELISA method.
  
  
  RESULTS
  The IFN-gamma values of treated leprosy patients, therapy receiving patients, relatives group's and control group's were detected as 11-20 pg/mL, 11-18 pg/mL, 12-145 pg/mL and 12-65 pg/mL respectively.
  
  
  CONCLUSIONS
  According to the statistical evaluation of these three groups, IFN-gamma levels of patients were detected lower than other two groups. According to the age, if IFN-gamma levels were compared, it was detected that significant relationship between relatives groups and interferon gamma levels.
authors.affiliation: Yüzüncü Yil University Faculty of Medicine, Van, Turkey. hguducu@hotmail.com
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Güdücüoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Berktaş
authors.forename: Hamza
authors.initials: H
authors.lastname: Bozkurt
authors.forename: Necmettin
authors.initials: N
authors.lastname: Akdeniz
authors.forename: Nihat
authors.initials: N
authors.lastname: Kutluay
authors.forename: Görkem
authors.initials: G
authors.lastname: Yaman
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Bayram
authors.forename: Safak
authors.initials: S
authors.lastname: Andiç
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005190:Family; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007918:Leprosy / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged
chemical_list: D007371:Interferon-gamma