Neurodevelopmental outcomes of very low-birth-weight infants after enteral glutamine supplementation in the neonatal period.
OBJECTIVE
To determine the effect of neonatal glutamine-enriched enteral nutrition in very low birth weight (VLBW) infants on neurodevelopmental outcome at 2 years of age.


METHODS
Eighty-eight out of one hundred two infants participating in the initial study were eligible for the follow-up study (13 died, one exclusion due to a chromosomal abnormality). Neurodevelopmental outcome (neurologic status, vision, hearing and Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) of the Bayley Scales of Infant Development II) was evaluated at the corrected age of 2 years. To adjust for potential confounders, data were analyzed by multiple linear or logistic regression (for continuous and dichotomous variables, respectively)


RESULTS
Seventy-two out of eighty-eight (82%) infants participated in the follow-up study: 40 and 32 infants in glutamine-supplemented and control groups, respectively. The incidence of neither an MDI nor a PDI <or= 85 was different in glutamine-supplemented and control groups (MDI <or= 85: 27 and 19%, p = 0.17; PDI <or= 85: 28 and 16% p = 0.16, respectively). The incidence of neurodevelopmental impairment was not different between both groups (OR: 2.16, 95% CI: 0.64-7.28).


CONCLUSIONS
A positive effect of neonatal glutamine-enriched enteral nutrition in VLBW infants on neurodevelopmental outcome at 2 years of age was not found in this study.
van Zwol
Annelies
A
Department of Pediatrics, Division of Neonatology, Amsterdam, The Netherlands.
van den Berg
Anemone
A
Huisman
Jaap
J
Vermeulen
R Jeroen
RJ
Fetter
Willem P
WP
Twisk
Jos W R
JW
van Elburg
Ruurd M
RM
D000328:Adult; D000465:Algorithms; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D004750:Enteral Nutrition / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005973:Glutamine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D009426:Netherlands; D011597:Psychomotor Performance / Q000145:classification / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic
D005973:Glutamine