Fly-let biology and the high protein/low carb diet.
In Drosophila, a simple network of nutrient-sensing neuroendocrine cells, analogs of pancreatic islet alpha and beta cells, regulates carbohydrate metabolism. Work presented in this issue of Cell Metabolism (Buch et al., 2008) shows that signals from these cells control expression of a glycogen-specific glucosidase in response to dietary protein and carbohydrate.
Rulifson
Eric
E
Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. rulifsone@stemcell.ucsf.edu
D000818:Animals; D050260:Carbohydrate Metabolism; D004032:Diet; D004040:Dietary Carbohydrates / Q000378:metabolism / Q000494:pharmacology*; D004044:Dietary Proteins / Q000378:metabolism / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D009490:Neurosecretory Systems / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism*
D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D006003:Glycogen; D000520:alpha-Glucosidases