Is insulin a factor in the genesis of the vascular complications of diabetes?
Several recent studies report that insulin may be a pathogenic factor in cardiovascular disease and the vascular complications of diabetes. The route of administration of insulin may be partially responsible for vascular side effects that occur in the management of diabetes. These side effects may be overcome by the development of a more physiologic route of administration than by subcutaneous injection.
Saffran
M
M
Department of Biochemistry Medical College of Ohio Toledo, OH 43699, USA.