Not just because it is there: aminoacyl-tRNA synthetases gain control of the cell.
In a recent issue of Molecular Cell, Jia et al. (2008) demonstrate that time-controlled repression of interferon-induced transcripts depends upon the interaction between an RNA structure in these transcripts and protein domains harbored by a mammalian aminoacyl-tRNA synthetase.
Ribas de Pouplana
Lluís
L
Institució Catalana de Recerca i Estudis Avançats, C/Baldiri Reixac, 15-21, Barcelona 08028, Catalonia, Spain. lluis.ribas@irbbarcelona.org
Geslain
Renaud
R
D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D007371:Interferon-gamma / Q000378:metabolism; D009690:Nucleic Acid Conformation; D017434:Protein Structure, Tertiary; D012313:RNA / Q000737:chemistry / Q000378:metabolism
D012313:RNA; D007371:Interferon-gamma; D000604:Amino Acyl-tRNA Synthetases