title: Chrysogenamide A from an endophytic fungus associated with Cistanche deserticola and its neuroprotective effect on SH-SY5Y cells.
abstract: Chrysogenamide A (1), a new member of the macfortine group of alkaloids, along with four known compounds (2 approximately 5) were identified from Penicillium chrysogenum No. 005, an endophytic fungus associated with Cistanche deserticola Y. C. Ma. The new structure was elucidated on the basis of comprehensive spectral analysis. 1 exhibited a neurocyte protection effect against oxidative stress-induced cell death in SH-SY5Y cells.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
authors.forename: Zhenjian
authors.initials: Z
authors.lastname: Lin
authors.forename: Jiangni
authors.initials: J
authors.lastname: Wen
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Fang
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D031671:Cistanche; D005285:Fermentation; D006801:Humans; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D010408:Penicillium chrysogenum / Q000378:metabolism*; D008517:Phytotherapy; D018547:Plant Stems; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000475:Alkenes; D018696:Neuroprotective Agents; D013141:Spiro Compounds; C530001:chrysogenamide A