[Neuroimmune regulation in children with bronchial asthma].
80 children aged from 2 to 14 years,72 boys and 8 girls, 44 with moderate and 36 with severe form of atopic bronchial asthma were investigated. Substance P, neurokinin A and vasoactive intestinal peptide (VIP) were defined in blood plasma. In comparison with the control group, children suffering from bronchial asthma showed statistically significant (p<0,001) increase of substance P and neurokinin A and decrease of VIP. Analogous changes were observed by comparison of data received from children with moderate and severe asthma. Received data indicate the participation of neuropeptides in pathogenesis of bronchial asthma in children.
Eiubova
A A
AA
Sultanova
N G
NG
D000293:Adolescent; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D015288:Neurokinin A / Q000276:immunology*; D013373:Substance P / Q000276:immunology*
D013373:Substance P; D015288:Neurokinin A