title: Metabolic syndrome after laparoscopic bariatric surgery.
abstract: BACKGROUND
  Metabolic syndrome (MS) is common among morbidly obese patients undergoing bariatric surgery. The aim of this study was to assess the impact and predictors of bariatric surgery on the resolution of MS.
  
  
  METHODS
  Subjects included 286 patients [age 44.0 +/- 11.5, female 78.2%, BMI 48.7 +/- 9.4, waist circumference 139 +/- 20 cm, AST 23.5 +/- 14.9, ALT 30.0 +/- 20.1, type 2 diabetes mellitus (DM) 30.1% and MS 39.2%] who underwent bariatric surgery.
  
  
  RESULTS
  Of the entire cohort, 27.3% underwent malabsorptive surgery, 55.9% underwent restrictive surgery, and 16.8% had combination restrictive-malabsorptive surgery. Mean weight loss was 33.7 +/- 20.1 kg after restrictive surgery (follow up period 298 +/- 271 days), 39.4 +/- 22.9 kg after malabsorptive surgery (follow-up period 306 +/- 290 days), and 28.3 +/- 14.1 kg after combination surgery (follow-up period 281 +/- 239 days). Regardless of the type of bariatric surgery, significant improvements were noted in MS (p values from <0.0001-0.01) as well as its components such as DM (p values from <0.0001-0.0005), waist circumference (p values <0.0001), BMI (p values <0.0001), fasting serum triglycerides (p values <0.0001 to 0.001), and fasting serum glucose (p values <0.0001). Additionally, a significant improvement in AST/ALT ratio (p value = 0.0002) was noted in those undergoing restrictive surgery. Multivariate analysis showed that patients who underwent malabsorptive bariatric procedures experienced a significantly greater percent excess weight loss than patients who underwent restrictive procedures (p value = 0.0451). Percent excess weight loss increased with longer postoperative follow-up (p value <0.0001).
  
  
  CONCLUSIONS
  Weight loss after bariatric surgery is associated with a significant improvement in MS and other metabolic factors.
authors.affiliation: Center for Liver Diseases, Inova Fairfax Hospital and Translational Research Institute, 3300 Gallows Road, Falls Church, VA, 22042, USA.
authors.forename: Clare
authors.initials: C
authors.lastname: Nugent
authors.forename: Chunhong
authors.initials: C
authors.lastname: Bai
authors.forename: Hazem
authors.initials: H
authors.lastname: Elariny
authors.forename: Priya
authors.initials: P
authors.lastname: Gopalakrishnan
authors.forename: Caitlin
authors.initials: C
authors.lastname: Quigley
authors.forename: Michael
authors.initials: M
authors.lastname: Garone
authors.forename: Mariam
authors.initials: M
authors.lastname: Afendy
authors.forename: Oscar
authors.initials: O
authors.lastname: Chan
authors.forename: Angela
authors.initials: A
authors.lastname: Wheeler
authors.forename: Arian
authors.initials: A
authors.lastname: Afendy
authors.forename: Zobair M
authors.initials: ZM
authors.lastname: Younossi
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000517:prevention & control*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss