title: Effect of statins on serum apolipoprotein j and paraoxonase-1 levels in patients with ischemic heart disease undergoing coronary angiography.
abstract: It has been proposed that apolipoprotein J (apo J) and paraoxonase-1 (PON1) correlate with the extent and severity of ischemic heart disease (IHD). This article compares apo J and PON1 serum concentrations, PON1 activity, and the apo J/PON1 ratio in 138 IHD patients (64 statins users and 74 statin nonusers) referred for angiography and possible percutaneous coronary intervention. The effect of statin treatment on apo J and PON1 concentrations, PON1 activity, and the degree of coronary artery stenosis were evaluated. In both groups, apo J levels were increased, whereas PON1 concentration and activity decreased. IHD patients on statins had significantly lower apo J concentration and higher PON1 concentration and activity. Patients on statins had less coronary artery stenosis. High apo J levels, low PON1 levels, low PON1 activity, and a high apo J/PON1 ratio were associated with IHD. Statin treatment reverses these changes, probably by multiple beneficial actions.
authors.affiliation: National and Kapodistrian University of Athens, Greece.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Poulakou
authors.forename: Kosmas I
authors.initials: KI
authors.lastname: Paraskevas
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vlachos
authors.forename: Sonia-Athena P
authors.initials: SA
authors.lastname: Karabina
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wilson
authors.forename: Dimitrios C
authors.initials: DC
authors.lastname: Iliopoulos
authors.forename: Serafim I
authors.initials: SI
authors.lastname: Tsitsilonis
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: Despina N
authors.initials: DN
authors.lastname: Perrea
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000187:drug effects; D051152:Clusterin / Q000097:blood* / Q000187:drug effects; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012720:Severity of Illness Index
chemical_list: C495242:CLU protein, human; D051152:Clusterin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human