title: [FISH technique in aneuplodies prenatal diagnosis].
abstract: Chromosomal disorders are severe and affect 0.9% of the newborns. In these conditions, prenatal diagnosis should be compulsory in every public medical system.
  
  
  METHODS
  Our study is a retrospective analysis of pregnant women investigated by amniocentesis and FISH technique.
  
  
  RESULTS
  We analyzed 233 samples collected between 2004 and 2007 at Iaşi "Cuza-Vodă" Obstetrics and Gynecology Hospital. The majority of cases were investigated between 16 and 24 weeks of pregnancy. Thirty-eight abnormal cases (16.30%) were identified: 17 cases with 21 trisomy, 16 cases with 18 trisomy, 3 cases with X monosomy, and 2 cases with 13 trisomy. The main reasons for amniocentesis were: advanced maternal age (12.5% abnormal cases) ultrasound abnormalities (26.15% abnormal cases), and biochemical abnormalities (7.14% abnormal cases).
  
  
  CONCLUSIONS
  Our data are in agreement with other studies, and support our results.
authors.affiliation: Disciplina de Genetică Medicală, Universitatea de Medicină si Farmacie "Gr.T. Popa", Iaşi.
authors.forename: E V
authors.initials: EV
authors.lastname: Gorduza
authors.forename: M
authors.initials: M
authors.lastname: Onofriescu
authors.forename: Violeta
authors.initials: V
authors.lastname: Martiniuc
authors.forename: Mihaela
authors.initials: M
authors.lastname: Grigore
authors.forename: Elena
authors.initials: E
authors.lastname: Mihălceanu
authors.forename: Gh
authors.initials: G
authors.lastname: Iliev
mesh_terms: D000649:Amniocentesis; D000782:Aneuploidy; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000235:genetics; D020732:Cytogenetic Analysis; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal