title: Coordinated prophylactic surgical management for women with hereditary breast-ovarian cancer syndrome.
abstract: BACKGROUND
  Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed to assess the feasibility of coordinated PM and BSO in hereditary breast-ovarian cancer syndrome.
  
  
  METHODS
  High risk women for breast and ovarian cancer who underwent coordinated PM and BSO were included in this study. Clinical characteristics and surgical and oncologic outcomes were retrospectively reviewed.
  
  
  RESULTS
  Twelve patients underwent coordinated PM and BSO. Ten had history of previous breast cancer. Autologous breast reconstruction was performed in ten patients. The mean age at surgery was 43 (range 34-65). Mean operating time was 9.3 hours (range 3-16) with a mean postoperative hospitalization of 5.4 days (range 4-8). Intraoperatively, there were no major surgical complications. Postoperatively, one patient developed an abdominal wound dehiscence, another reoperation for flap congestion; one had umbilical superficial epidermolysis, and one patient developed aspiration pneumonia. At a mean follow-up of 84 months, 10 of patients were cancer-free. Although no patients developed a new primary cancer, two developed a distant recurrence.
  
  
  CONCLUSIONS
  Coordinated PM and BSO is a feasible procedure with acceptable morbidity in selected high-risk patients that desire to undergo surgery at one operative setting.
authors.affiliation: Department of Surgical Oncology, The University of Texas M, D, Anderson Cancer Center, Houston, TX, USA. lara.rs@terra.com.br
authors.forename: Larissa I
authors.initials: LI
authors.lastname: Batista
authors.forename: Karen H
authors.initials: KH
authors.lastname: Lu
authors.forename: Elisabeth K
authors.initials: EK
authors.lastname: Beahm
authors.forename: Banu K
authors.initials: BK
authors.lastname: Arun
authors.forename: Diane C
authors.initials: DC
authors.lastname: Bodurka
authors.forename: Funda
authors.initials: F
authors.lastname: Meric-Bernstam
mesh_terms: D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000517:prevention & control / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D010052:Ovariectomy; D012189:Retrospective Studies; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D051017:Apoptosis Regulatory Proteins; C118024:BLID protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases