Mitosis: moesin and the importance of being round.
Ezrin/radixin/moesin proteins link the actin cytoskeleton to the plasma membrane. Two new reports have found that moesin phosphorylation is essential for mitotic cell rounding and identify a new role for cell rounding in spindle assembly.
Rosenblatt
Jody
J
University of Utah, Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA. jody.rosenblatt@hci.utah.edu
D000199:Actins / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D048430:Cell Shape / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism* / Q000502:physiology; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D000199:Actins; D029721:Drosophila Proteins; D008565:Membrane Proteins; C099886:moesin, Drosophila; D017346:Protein Serine-Threonine Kinases; C492662:Slik protein, Drosophila