Gabexate mesilate suppresses influenza pneumonia in mice through inhibition of cytokines.
Gabexate mesilate is a synthetic protease inhibitor that is effective for acute pancreatitis. The effect of gabexate mesilate in influenza pneumonia in mice was investigated by examining the changes in pulmonary inflammatory cytokines and chemokines. Pathological changes in the lungs of treated mice were extremely mild, compared with changes in infected, untreated mice. Intrapulmonary levels of interleukin-6 and macrophage inflammatory protein-2 decreased in treated mice compared with untreated mice, despite similar viral titres in the lungs. Survival terms for treated and untreated groups were similar. These data indicate that gabexate mesilate has beneficial effects on influenza pneumonia, which may be due to the modulation of inflammatory cytokine/chemokine responses.
Kosai
K
K
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan.
Seki
M
M
Yanagihara
K
K
Nakamura
S
S
Kurihara
S
S
Izumikawa
K
K
Kakeya
H
H
Yamamoto
Y
Y
Tashiro
T
T
Kohno
S
S
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D002460:Cell Line; D016207:Cytokines / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D004285:Dogs; D016670:Gabexate / Q000008:administration & dosage*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011024:Pneumonia, Viral / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011897:Random Allocation
D000998:Antiviral Agents; D016207:Cytokines; D016670:Gabexate