title: Membrane proteins as diagnostic biomarkers and targets for new therapies.
abstract: Membrane proteins, especially plasma membrane proteins, form one of the most interesting classes of proteins among disease biomarker candidates. Because of their localization on the surface of cells and organelles, membrane proteins also represent potential drug targets. In this review, developments in the characterization of membrane proteins and their role in the treatment of disease, in particular cancer treatment, are presented.
authors.affiliation: Rhode Island Hospital, COBRE Center for Cancer Research Development, Proteomics Core, Suite 4, 206 Coro West, 1 Hoppin Street, Providence, RI 02903, USA. djuro_josic@brown.edu
authors.forename: Djuro
authors.initials: D
authors.lastname: Josic
authors.forename: James G
authors.initials: JG
authors.lastname: Clifton
authors.forename: Spomenka
authors.initials: S
authors.lastname: Kovac
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Hixson
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis* / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D011499:Protein Processing, Post-Translational
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins