title: Modulation of radiation-induced biochemical changes in cerebrum of Swiss albino mice by Grewia Asiatica.
abstract: The present study evaluates the possible radioprotective effect of Grewia asiatica fruit (rich in anthocyanin, carotenes, vitamin C, etc.) pulp extract (GAE) on cerebrum of Swiss albino mice exposed to 5 Gy gamma radiation. For this, healthy mice from an inbred colony were divided into four groups: (1) Control (vehicle treated) (2) GAE treated - mice in this group were orally supplemented with GAE (700 m/kg. b.w./day) once daily for fifteen consecutive days, (3) Vehicle treated irradiated mice, and (4) GAE + Irradiated - Mice in this group received distilled water orally equivalent to GAE (700 m/kg. b.w/day) for fifteen days consecutively. Mice were sacrificed at various intervals viz. 1-30 days. Radiation-induced augmentation in the levels of lipid peroxidation of mice cerebrum was significantly ameliorated by GAE pretreatment. Radiation-induced depletion in the level of glutathione and protein was prevented significantly by GAE administration.
authors.affiliation: Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, 302004 India. rashsisodia@yahoo.co.in.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Sisodia
authors.forename: Muktika
authors.initials: M
authors.lastname: Ahaskar
authors.forename: K V
authors.initials: KV
authors.lastname: Sharma
authors.forename: Smita
authors.initials: S
authors.lastname: Singh
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000528:radiation effects; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays / Q000009:adverse effects; D005978:Glutathione / Q000378:metabolism; D032382:Grewia / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013858:Thiobarbiturates / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D011837:Radiation-Protective Agents; D013858:Thiobarbiturates; D005978:Glutathione; C029684:thiobarbituric acid