title: Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma.
abstract: OBJECTIVE
  To evaluate the associations between diet and non-Hodgkin lymphoma (NHL) according to t(14;18) status, one of the most common chromosomal abnormalities in NHL, as t(14;18)-positive NHL represents a genetically more homogeneous group than NHL overall.
  
  
  METHODS
  We determined the presence of the t(14;18)(q32;q21) by fluorescence in situ hybridization in 172 of 175 tumor blocks from a population-based, case-control study conducted in Nebraska during 1983-1986. Information on the frequency of consumption as an adult of 30 food items was derived from the parent case-control study. Dietary factors in 60 t(14;18)-positive and 87 t(14;18)-negative cases were compared with 1,075 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using polytomous logistic regression.
  
  
  RESULTS
  The risk of t(14;18)-positive NHL for the highest versus the lowest approximate tertile of intake was elevated for milk (OR = 2.2; 1.0-5.0) and dietary nitrite (OR = 2.8; 1.3-6.1), whereas coffee consumption was inversely associated with risk (OR = 0.4; 0.2-0.7). We also found inverse associations between the intake of fish (OR = 0.5; 0.3-1.0) and carotene (OR = 0.5; 0.2-0.9) and risk of t(14;18)-negative NHL. There was no association between the intake of meats, vegetables, protein, or vitamin C and risk of either t(14;18)-positive or t(14;18)-negative NHL.
  
  
  CONCLUSIONS
  We observed differences in associations between diet and t(14;18)-defined subgroups of NHL. These findings should be interpreted cautiously because of the small sample.
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611-4402, USA. bchiu@northwestern.edu
authors.forename: Brian C-H
authors.initials: BC
authors.lastname: Chiu
authors.forename: Bhavana J
authors.initials: BJ
authors.lastname: Dave
authors.forename: Mary H
authors.initials: MH
authors.lastname: Ward
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Fought
authors.forename: Lifang
authors.initials: L
authors.lastname: Hou
authors.forename: Smrati
authors.initials: S
authors.lastname: Jain
authors.forename: Susan
authors.initials: S
authors.lastname: Gapstur
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Evens
authors.forename: Shelia Hoar
authors.initials: SH
authors.lastname: Zahm
authors.forename: Aaron
authors.initials: A
authors.lastname: Blair
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Weisenburger
mesh_terms: D016022:Case-Control Studies; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D004032:Diet; D002149:Energy Intake; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D009329:Nebraska / Q000453:epidemiology; D012307:Risk Factors; D014178:Translocation, Genetic / Q000235:genetics*