[Effect of Ca2+ complexation on oxygen partial pressure in the Bladder Meridian in goats].
OBJECTIVE
To explore the relationship between energy metabolism and meridian phenomenon. Methods Ten Boer hybridism goats mitigated under chlorpromazine (0.85 mg/kg, intramuscular injection) were subjected to the present study. Changes of oxygen partial pressure (PO2) in "Ganshu" (BL 18), "Dachangshu" (BL 25) and "Guanyuanshu" (BL 26) of Bladder Meridian and in 3 non-acupoints (3 cm apart from BL18, BL25 and BL26 separately on the unilateral side) were recorded by using a needle-type tissue oxygen tension sensor before and following local injection of EDTA-Na2 (200 microL, 0.05 kg/mol, for complexing Ca2+) and 0.9% saline.


RESULTS
(1) Compared with the corresponding non-acupoints, Ca2+ potentials in BL18, BL25 and BL26 were all significantly higher (P < 0.05, 0.01). (2) In comparison with the corresponding non-acupoints, the values of tissue PO2 of BL18 and BL26 were significantly higher (P < 0.01). (3) After injection of EDTA-Na2, PO2 values in both BL18, BL26, and their respective non-acupoints increased significantly in comparison with those of either injection of saline or their respective basal values (P < 0.01, 0.05). Compared with those of their corresponding non-acupoints PO2 values in both BL18 and BL26 increased markedly (P < 0.01).


CONCLUSIONS
Ca2+ potential of the Bladder Meridian was significantly higher than that of non-acupoints, and after complexing Ca2+, PO2 in acupoints and non-acupoints increased markedly, suggesting that Ca2+ may play an important role in meridian signaling and production of acupuncture effect.
Wang
Qi
Q
Institute of Integrated Chinese and Western Medicine, Tongji Hospital, China. wangqixlp@hotmail.com
Jiang
Hong-zhi
HZ
Chen
Sheng-li
SL
Zhang
Ming-min
MM
Ding
Ming-xing
MX
Kong
E-sheng
ES
Huang
Guang-ying
GY
D015669:Acupuncture Points; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004492:Edetic Acid / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D006041:Goats / Q000502:physiology*; D016740:Meridians; D010100:Oxygen; D010313:Partial Pressure; D001743:Urinary Bladder
D004492:Edetic Acid; D010100:Oxygen; D002118:Calcium