title: Effect of Aerodiol administration on ocular arteries in postmenopausal women.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the alteration of ocular blood hemodynamics after intranasal administration of 17beta-estradiol, through measurement of the ophthalmic artery (OA) and the central retinal artery (CRA) using color duplex sonography.
  
  
  METHODS
  Thirty healthy women who had been naturally postmenopausal for at least 1 year were enrolled in the study. A randomized, placebo-controlled, crossover, double-blinded study was conducted of the acute effect of 17beta-estradiol (Aerodiol; Servier, Chambrayles-Tours, France) on OA and CRA blood flow using color duplex sonography.
  
  
  RESULTS
  The peak systolic and end diastolic velocities of the CRA were increased significantly after 17beta-estradiol administration compared with placebo. A significant decrease was also found in the pulsatility and resistive indices of the CRA. However, there were no statistically significant differences in OA flow velocities or pulsatility and resistive indices.
  
  
  CONCLUSIONS
  Nasal 17beta-estradiol administration in postmenopausal women causes an improvement in the ocular vascular Doppler indices. These results suggest that there could be a positive effect of Aerodiol on middle-sized arteries and arterioles.
authors.affiliation: Department of Obstetrics and Gynecology, Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey. dr_figenkir@hotmail.com
authors.forename: Figen Kir
authors.initials: FK
authors.lastname: Sahin
authors.forename: Gulengul
authors.initials: G
authors.lastname: Koken
authors.forename: Emine
authors.initials: E
authors.lastname: Cosar
authors.forename: Dagistan Tolga
authors.initials: DT
authors.lastname: Arioz
authors.forename: Bumin
authors.initials: B
authors.lastname: Degirmenci
authors.forename: Ramazan
authors.initials: R
authors.lastname: Albayrak
authors.forename: Murat
authors.initials: M
authors.lastname: Acar
mesh_terms: D000281:Administration, Intranasal; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000187:drug effects*; D010919:Placebos; D017698:Postmenopause / Q000187:drug effects; D012161:Retinal Artery / Q000187:drug effects*
chemical_list: D010919:Placebos; D004958:Estradiol