[Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of Ets factors].
To regulate the spatiotemporal expression of their target genes, the transcription factors undergo post-translational modifications of which the most studied is phosphorylation. Acetylation and ubiquitinylation on lysine residues also exert a role in the transcription, as it is the case for the regulation of the activity of the huge family of Ets transcription factors. Recently, sumoylation, a post-translational modification similar to ubiquitinylation, was described as playing a crucial role in the inhibition of the activity of these factors.
de Launoit
Y
Y
UMR 8161, Institut de Biologie de Lille, CNRS, Université de Lille I, France.
Degerny
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C
Wohlkonig
A
A
Baert
J L
JL
D000107:Acetylation; D000818:Animals; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics / Q000378:metabolism*; D025842:SUMO-1 Protein / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D050784:Proto-Oncogene Protein c-ets-1; D025842:SUMO-1 Protein; D025801:Ubiquitin; D008239:Lysine