title: Periodontal disease and endometriosis: analysis of the National Health and Nutrition Examination Survey.
abstract: OBJECTIVE
  To investigate whether an association exists between endometriosis and periodontal disease, because endometriosis and periodontal disease are chronic, inflammatory processes more common in patients with systemic autoimmune disorders and because each disease alters immune modulators.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  University health system and statistical center.
  
  
  METHODS
  Data for 4136 women, ages 18-50, in the National Health and Nutrition Examination Survey, 1999-2004.
  
  
  METHODS
  None.
  
  
  METHODS
  Periodontitis and gingivitis among those patients with and without self-reported endometriosis.
  
  
  RESULTS
  Multinomial logistic regression showed that women with self-reported endometriosis had significantly (57%) higher odds of having both gingivitis and periodontitis relative to not having periodontal disease, compared with women without self-reported endometriosis (adjusted odds ratio, 1.57; 95% confidence interval, 1.06, 2.33), when controlling for other relevant factors.
  
  
  CONCLUSIONS
  The results of this study suggest a possible association between endometriosis and periodontal disease. Although it is conceivable that the multifactorial development of endometriosis may be augmented by an immune response to an infectious agent, the potential underlying link between endometriosis and periodontal disease may be a generalized, global immune dysregulation.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan Endometriosis Center, Ann Arbor, Michigan 48109, USA.
authors.forename: Shahryar K
authors.initials: SK
authors.lastname: Kavoussi
authors.forename: Brady T
authors.initials: BT
authors.lastname: West
authors.forename: George W
authors.initials: GW
authors.lastname: Taylor
authors.forename: Dan I
authors.initials: DI
authors.lastname: Lebovic
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D004715:Endometriosis / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D005891:Gingivitis / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D010510:Periodontal Diseases / Q000453:epidemiology* / Q000276:immunology; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult