Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome.
BACKGROUND
Skipping meals is a common practice in our current society; however, it is not clear whether eating meals regularly is associated with the metabolic syndrome.


OBJECTIVE
Our aim was to assess the association of eating meals regularly with parameters of the metabolic syndrome and insulin resistance in a representative population-based cohort of 60-year-old men and women.


METHODS
A population-based cross-sectional study of 3,607 individuals (1,686 men and 1,921 women), aged 60 years, was conducted in Stockholm County, Sweden. Medical history, socioeconomic factors, and lifestyle data were collected by a questionnaire and a medical examination, which included laboratory tests.


RESULTS
Of the subjects who were regular eaters, 20% fulfilled the criteria for the metabolic syndrome vs. 27% of subjects who were irregular eaters (P < 0.0001). The adjusted odds ratio (OR) for having the greatest number of components of the metabolic syndrome in subjects who were regular eaters was 0.27 (95% confidence interval (CI), 0.13-0.54) using subjects who did not fulfill any criteria for the metabolic syndrome as a reference group. Eating meals regularly was also inversely related to insulin resistance (OR, 0.68 (95% CI, 0.48-0.97)) and to gamma-glutamyl transferase (OR, 0.52 (95% CI, 0.33-83)) after full adjustment.


CONCLUSIONS
Eating meals regularly is inversely associated to the metabolic syndrome, insulin resistance and (high) serum concentrations of gamma-glutamyl transferase. These findings suggest that eating meals irregularly may be part of several potential environmental risk factors that are associated with the metabolic syndrome and may have future implications in giving dietary advice to prevent and/or treat the syndrome.
Sierra-Johnson
Justo
J
Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Stockholm, Sweden. jusier@ki.se
Undén
Anna-Lena
AL
Linestrand
Madeleine
M
Rosell
Magdalena
M
Sjogren
Per
P
Kolak
Maria
M
De Faire
Ulf
U
Fisher
Rachel M
RM
Hellénius
Mai-Lis
ML
D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003625:Data Collection; D004435:Eating / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000503:physiopathology*; D008875:Middle Aged; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
D005723:gamma-Glutamyltransferase