Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates.
Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can partially protect macaques after challenge with Zaire ebolavirus. Here, we administered a VSV vector expressing the Sudan ebolavirus (SEBOV) glycoprotein to four rhesus macaques shortly after exposure to SEBOV. All four animals survived SEBOV challenge, while a control animal that received a nonspecific vector developed fulminant SEBOV hemorrhagic fever and succumbed. This is the first demonstration of complete postexposure protection against an Ebola virus in nonhuman primates and provides further evidence that postexposure vaccination may have utility in treating exposures to filoviruses.
Geisbert
Thomas W
TW
National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA. geisbert@bu.edu
Daddario-DiCaprio
Kathleen M
KM
Williams
Kinola J N
KJ
Geisbert
Joan B
JB
Leung
Anders
A
Feldmann
Friederike
F
Hensley
Lisa E
LE
Feldmann
Heinz
H
Jones
Steven M
SM
D000818:Animals; D029043:Ebolavirus / Q000502:physiology*; D005822:Genetic Vectors / Q000235:genetics*; D019142:Hemorrhagic Fever, Ebola / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control*; D008253:Macaca mulatta / Q000097:blood / Q000821:virology*; D015996:Survival Rate; D018116:Vesiculovirus / Q000235:genetics*