title: Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri.
abstract: The synthesis of (+/-)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied against Candida albicans (14053 and ATCC 10231), Candida inconspicua, Candida dubliniensis and Candida krusei.
authors.affiliation: Department of Organic Chemistry, University of Debrecen, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Kenéz
authors.forename: Zsombor
authors.initials: Z
authors.lastname: Lestár
authors.forename: Béla
authors.initials: B
authors.lastname: Lenkey
authors.forename: Sándor
authors.initials: S
authors.lastname: Antus
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005779:Immunodiffusion; D009682:Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D044950:Flavanones