title: Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease.
abstract: OBJECTIVE
  To determine factors predictive for esophageal varices in severe alcoholic disease (SAD).
  
  
  METHODS
  Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables.
  
  
  RESULTS
  Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type IV collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type IV collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type IV collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78.
  
  
  CONCLUSIONS
  This study suggests that the level of type IV collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine, Tokyo 105-8461, Japan. mamori@jikei.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mamori
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Searashi
authors.forename: Masato
authors.initials: M
authors.lastname: Matsushima
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uetake
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsudaira
authors.forename: Shuji
authors.initials: S
authors.lastname: Ito
authors.forename: Hisato
authors.initials: H
authors.lastname: Nakajima
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000150:complications*; D019540:Area Under Curve; D024141:Collagen Type IV / Q000097:blood*; D004932:Esophageal and Gastric Varices / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods
chemical_list: D024141:Collagen Type IV