title: The prognostic impact of blood group-related antigen Lewis Y and the ABH blood groups in resected non-small cell lung cancer.
abstract: The blood group antigen Lewis Y is expressed on epithelial tumors of the respiratory, digestive and reproductive system. Despite being regarded as an attractive target for immunotherapy, its function is still not well defined and its prognostic value remains a subject of discussion. Eighty-three paraffin-embedded tissue sections of non-small cell lung cancer (NSCLC) patients in stage I-IIIa, who underwent surgical resection of the primary tumor (73% male; 43% adenocarcinoma), were stained with a new, highly specific monoclonal antibody against Lewis Y (clone A70-C/C8). A positive Lewis Y expression was observed in 51% of patients; adenocarcinomas were favorably stained (67%). Multivariate analysis identified stage I, blood group A or AB and Lewis Y expression on tumor cells to be independent markers for improved survival after tumor resection (p = 0.024, 0.043, 0.003, respectively). In summary, unlike in several previous studies the presence of Lewis Y on tumor cells is a favorable prognostic factor in this cohort of resected NSCLC patients. Coexisting blood group antigen A may be of additional positive prognostic impact. We hypothesize that related blood group antigens both on tumor cells and in peripheral blood may have an underestimated function for progression in resected NSCLC.
authors.affiliation: Pulmonary Division, Department of Medicine III, Johannes Gutenberg University Medical Center, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kuemmel
authors.forename: Kristjan
authors.initials: K
authors.lastname: Single
authors.forename: Fernando
authors.initials: F
authors.lastname: Bittinger
authors.forename: Andrea
authors.initials: A
authors.lastname: Faldum
authors.forename: Lars Henning
authors.initials: LH
authors.lastname: Schmidt
authors.forename: Martin
authors.initials: M
authors.lastname: Sebastian
authors.forename: Christian
authors.initials: C
authors.lastname: Taube
authors.forename: Roland
authors.initials: R
authors.lastname: Buhl
authors.forename: Rainer
authors.initials: R
authors.lastname: Wiewrodt
mesh_terms: D000017:ABO Blood-Group System / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007983:Lewis Blood Group Antigens / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D000017:ABO Blood-Group System; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007983:Lewis Blood Group Antigens; C094162:Lewis Y antigen