title: Role of diffusion-weighted MRG in predicting outcome in subarachnoid hemorrhage due to anterior communicating artery aneurysms.
abstract: OBJECTIVE
  Efficacy of DWI in detecting ischemic injury following anterior communicating artery aneurysmal SAH is studied
  
  
  METHODS
  In this prospective study ,16 patients within 5 days of their ictus were included. Preoperative CT scan excluded an intracerebral infarct; an angiogram determined the extent of vasospasm; MR studies were done to detect cerebral ischemia and the diffusion coefficient (ADC) was calculated. Patients underwent surgery (n=12) or endovascular coiling (n=4). Postintervention CT scan within 24 hours and on day 5 determined radiological outcome as good or poor depending on the absence or presence of infarction. Clinical outcome at follow up (2-6 months) was regarded as good or poor when the patient was independent or dependent regarding daily activities, respectively,.
  
  
  RESULTS
  Restricted diffusion occurred in 8 (80%) of poor and in 1 (16.6%) of good grade patients (p < 0.05). In patients with good radiological outcome (n=8), DWI restriction occurred in 2 (25%) patients. In patients with poor radiological outcome(n=8), DWI restriction occurred in 7 (87.5%) patients . At 2-6 month follow-up, 7 (77.8%) of 9 patients with restricted diffusion and 2 of 7 patients with no DWI abnormality showed a poor clinical outcome
  
  
  CONCLUSIONS
  Clinical and radiological outcome at follow-up is related to the preoperative DWI.
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Neurosurgery, UP, India. abrarwani@rediffmail.com
authors.forename: Abrar Ahad
authors.initials: AA
authors.lastname: Wani
authors.forename: Rv
authors.initials: R
authors.lastname: Phadke
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Rn
authors.initials: R
authors.lastname: Sahu
authors.forename: Awdesh
authors.initials: A
authors.lastname: Jaiswal
authors.forename: Vk
authors.initials: V
authors.lastname: Jain
mesh_terms: D000208:Acute Disease; D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000473:pathology