AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia.
Pre-eclampsia is a common, pregnancy-induced disorder, consisting of hypertension and proteinuria. The condition is one of the leading causes for maternal and perinatal morbidity and mortality. Nonetheless, the underlying molecular mechanisms remain unclear. Immunological mechanisms and the renin-angiotensin system have been implicated in the development of pre-eclampsia. Agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) have been identified in pre-eclamptic patients, unifying the two hypothesis. Evidence has also accumulated for the existence and importance of a local, utroplacental renin-angiotensin system. We summarize recent data emphasizing the pathophysiological role for the autoantibodies and the uteroplacental renin-angiotensin system.
Herse
Florian
F
Medical Faculty of the Charité, Franz-Volhard Clinic, HELIOS Clinic, Berlin, Germany.
Staff
Anne Cathrine
AC
Hering
Lydia
L
Müller
Dominik N
DN
Luft
Friedrich C
FC
Dechend
Ralf
R
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D021041:Placental Circulation / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D012084:Renin-Angiotensin System / Q000276:immunology*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism
D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D040281:Vascular Endothelial Growth Factor Receptor-1