title: Frequency and treatment of depressive symptoms in a Parkinson's disease registry.
abstract: Purpose of this cross-sectional study was to estimate the occurrence of depressive symptoms, as related to other clinical data, in a sample of Parkinson's disease (PD) patients (n=226). Furthermore, we examined the medical care of depressive symptoms in this sample. H&Y stages, cognitive status, sleeping disorders, and dysphagia resulted as significant predictors for depression. Prevalence of depressive symptoms was 35.4%. Only 25.0% of patients suffering from moderate to severe depressive symptoms were prescribed antidepressants. This study supports the view that depression may be underrecognized and undertreated in PD patients. A significant proportion of patients continues to experience depressive symptoms despite antidepressive medication. Recognition and treatment of depression remains a challenge for management of PD. Possible coexisting depressive symptoms should be revealed and assessed by standardized interviews in everyday clinical routine. Large scale randomized controlled trials examining efficacy and safety of antidepressants in PD patients are urgently required.
authors.affiliation: Department of Neurology, Philipps-University of Marburg, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Althaus
authors.forename: Oliver Arránz
authors.initials: OA
authors.lastname: Becker
authors.forename: Annika
authors.initials: A
authors.lastname: Spottke
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dengler
authors.forename: Frank
authors.initials: F
authors.lastname: Schneider
authors.forename: Manja
authors.initials: M
authors.lastname: Kloss
authors.forename: Karla
authors.initials: K
authors.lastname: Eggert
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Ulrich
authors.initials: U
authors.lastname: Dillmann
authors.forename: Birgit
authors.initials: B
authors.lastname: Herting
authors.forename: Joseph
authors.initials: J
authors.lastname: Classen
authors.forename: Richard
authors.initials: R
authors.lastname: Dodel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003710:Demography; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D055656:Prescriptions / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales; D012042:Registries; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents