title: Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry.
abstract: A simple and rapid method has been established for the screening of the main phenolic compounds in Artemisia annua by LC-DAD-ESI-MS(n). A total of 40 phenolic compounds were identified or tentatively characterized in the methanol extract of A. annua, including 8 C-glycosyl flavonoids, 5 O-glycosyl flavonoids, 3 flavonoid aglycones, 21 quinic acid derivatives, 2 benzoicacid glucosides and 1 coumarin. The C-glycosyl flavonoids were reported from A. annua for the first time and they were found to be a new type of main constituents, and might be responsible for its antioxidant and antiviral activity. Quinic acid derivatives were also found to be the major constituents of A. annua.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Min
authors.initials: M
authors.lastname: Ye
authors.forename: Xue
authors.initials: X
authors.lastname: Qiao
authors.forename: Man
authors.initials: M
authors.lastname: Xu
authors.forename: Bao-Rong
authors.initials: BR
authors.lastname: Wang
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D031172:Artemisia annua / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D047309:Flavones / Q000032:analysis*; D006027:Glycosides / Q000032:analysis*; D010936:Plant Extracts / Q000032:analysis*; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D047309:Flavones; D006027:Glycosides; D010936:Plant Extracts; D011801:Quinic Acid