title: Multifocal extranodal non-Hodgkin lymphoma involving both the lungs and brain in a child with primary immunodeficiency.
abstract: Immunodeficiency is associated with increased susceptibility to infections and B-cell lymphoproliferative disorders, which range from polyclonal proliferations to monoclonal lymphomas. In primary immunodeficiencies, the true incidence of lymphoproliferative disorders has been estimated between 1.4% and 24%. Recurrent or chronic infections resulting in continuous antigen exposure result in abnormal B-cell proliferation and ultimately lymphoma. Immunosuppression leads to increase in likelihood of Epstein-Barr virus-associated malignancies. We report a case of the child with multifocal extranodal non-Hodgkin lymphoma involving both the lungs and brain in a case of primary immunodeficiency.
authors.affiliation: Department of Histopathology, PGIMER, Chandigarh, India. docaman5@hotmail.com
authors.forename: Amanjit
authors.initials: A
authors.lastname: Bal
authors.forename: Anju
authors.initials: A
authors.lastname: Gupta
authors.forename: Kushaljit Singh
authors.initials: KS
authors.lastname: Sodhi
authors.forename: Ashim
authors.initials: A
authors.lastname: Das
authors.forename: Surjit
authors.initials: S
authors.lastname: Singh
mesh_terms: D001344:Autopsy; D001932:Brain Neoplasms / Q000473:pathology*; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008175:Lung Neoplasms / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*