Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis.
COMT gene is a logical candidate gene for schizophrenia. Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls. In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt.
Mata
Ignacio
I
University Hospital Marques de Valdecilla, Department of Psychiatry, Santander (Cantabria), Spain.
Perez-Iglesias
Rocio
R
Pelayo-Teran
Jose Maria
JM
Rodríguez-Sanchez
Jose Manuel
JM
Gonzalez-Blanch
Cesar
C
Carrasco-Marin
Eugenio
E
Vazquez-Barquero
Jose Luis
JL
Crespo-Facorro
Benedicto
B
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008715:Methionine / Q000235:genetics; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012565:Schizophrenic Psychology; D014633:Valine / Q000235:genetics
D014150:Antipsychotic Agents; D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine