title: Adenocarcinoma of lung in never smoked children.
abstract: Except in developed countries, the incidence of lung cancer notably in women and non-smokers is rising in most parts of the world. Here, we report two children diagnosed with pulmonary adenocarcinoma at a very early age. Interestingly, both showed negative EGFR mutation despite their ethnicity, histology, never smoking status and early age. Furthermore, one had preceding pulmonary tuberculosis. In the literature, the possible association of pulmonary tuberculosis and adenocarcinoma of lung especially in non-smokers has long been debated. The two children, by far the youngest with EGFR negative adenocarcinoma of lung, form the basis of this report.
authors.affiliation: Pediatric Oncology Center, National Cancer Center, 809 Madu1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do 410-769, Ilsan, Republic of Korea.
authors.forename: Jeong-A
authors.initials: JA
authors.lastname: Park
authors.forename: Hyeon-Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Jeong-Ok
authors.initials: JO
authors.lastname: Ha
authors.forename: Geon-Kook
authors.initials: GK
authors.lastname: Lee
authors.forename: Byung-Kiu
authors.initials: BK
authors.lastname: Park
authors.forename: Thad T
authors.initials: TT
authors.lastname: Ghim
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D000293:Adolescent; D003371:Cough; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009362:Neoplasm Metastasis; D013902:Radiography, Thoracic; D012307:Risk Factors; D012907:Smoking; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D015431:Weight Loss