New strategies for the synthesis of pyrimidine derivatives.
Recent advances in pyrimidine synthesis are described. Modification of conventional strategies involving N-C-N fragment condensation with 1,3-dicarbonyl derivatives remains a common theme in current literature. Other methods, including N-C fragment condensation strategies, provide reactive intermediates capable of intramolecular cyclization and formation of pyrimidine derivatives. These recently developed methodologies offer a valuable addendum to azaheterocycle synthesis.
Hill
Matthew D
MD
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
Movassaghi
Mohammad
M
D000478:Alkylation; D000577:Amides / Q000737:chemistry; D000812:Anhydrides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D017606:Chlorine Compounds / Q000737:chemistry; D004951:Esterification; D017611:Fluorine Compounds / Q000737:chemistry; D008697:Methane / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
D000577:Amides; D000812:Anhydrides; D002264:Carboxylic Acids; D017606:Chlorine Compounds; D017611:Fluorine Compounds; D011743:Pyrimidines; D013457:Sulfur Compounds; D014753:Vinyl Compounds; D002244:Carbon; C030986:pyrimidine; D009584:Nitrogen; D008697:Methane