Protamine usage following implantation of drug-eluting stents: a word of caution.
The treatment of hemorrhagic complications of percutaneous interventions with protamine is an accepted practice. Concerns exist about the increased thrombo-genicity of drug-eluting stents. We report two cases of acute stent thrombosis following drug-eluting stent implantation related to protamine administration.
Cosgrave
John
J
Columbus and San Raffaele Hospitals, Milan, Italy.
Qasim
Asif
A
Latib
Azeem
A
Aranzulla
Tiziana C
TC
Colombo
Antonio
A
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D054855:Drug-Eluting Stents; D017809:Fatal Outcome; D006470:Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D006494:Heparin Antagonists / Q000009:adverse effects*; D006801:Humans; D011479:Protamines / Q000009:adverse effects*
D006494:Heparin Antagonists; D011479:Protamines