Ataxia caused by amiodarone in older people.
Amiodarone is recommended for the cardioversion of atrial fibrillation and prevention of paroxysmal atrial fibrillation in patients with structural heart disease, coronary artery disease or left ventricular dysfunction. It has well-recognised side-effects on the skin, lungs, liver, thyroid and eyes. Neurological side-effects, including ataxia and neuropathy, also occur, and may be more prevalent in older patients. These side-effects are reversible after cessation of amiodarone. Monitoring of amiodarone therapy should include assessment of the central and peripheral nervous system especially in older patients.
Hindle
J V
JV
Department of Care of the Elderly, Llandudno Hospital, North West Wales NHS Trust, Llandudno, Conwy, LL30 1LB, UK. john.hindle@nww-tr.wales.nhs.uk
Ibrahim
Amin
A
Ramaraj
Radhakrishnan
R
D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001259:Ataxia / Q000139:chemically induced*; D001281:Atrial Fibrillation / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone