Structure-activity relationship of pamamycins: effect of side chain length on aerial mycelium-inducing activity.
Two pamamycin homologues with different side chain lengths were isolated from Streptomyces sp. HKI-0118. Aerial mycelium-inducing activity decreased by ca. 1/10 per methylene unit in the side chain.
Kozone
Ikuko
I
United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu, Tokyo, Japan.
Hashimoto
Makoto
M
Gräfe
Udo
U
Kawaide
Hiroshi
H
Abe
Hiroshi
H
Natsume
Masahiro
M
D002851:Chromatography, High Pressure Liquid; D018942:Macrolides; D015394:Molecular Structure; D025282:Mycelium / Q000187:drug effects* / Q000378:metabolism; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces; D013329:Structure-Activity Relationship
D018942:Macrolides; D009930:Organic Chemicals; C024500:pamamycin