title: [Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of Ets factors].
abstract: To regulate the spatiotemporal expression of their target genes, the transcription factors undergo post-translational modifications of which the most studied is phosphorylation. Acetylation and ubiquitinylation on lysine residues also exert a role in the transcription, as it is the case for the regulation of the activity of the huge family of Ets transcription factors. Recently, sumoylation, a post-translational modification similar to ubiquitinylation, was described as playing a crucial role in the inhibition of the activity of these factors.
authors.affiliation: UMR 8161, Institut de Biologie de Lille, CNRS, Université de Lille I, France.
authors.forename: Y
authors.initials: Y
authors.lastname: de Launoit
authors.forename: C
authors.initials: C
authors.lastname: Degerny
authors.forename: A
authors.initials: A
authors.lastname: Wohlkonig
authors.forename: J L
authors.initials: JL
authors.lastname: Baert
mesh_terms: D000107:Acetylation; D000818:Animals; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics / Q000378:metabolism*; D025842:SUMO-1 Protein / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D050784:Proto-Oncogene Protein c-ets-1; D025842:SUMO-1 Protein; D025801:Ubiquitin; D008239:Lysine