Haemostatic effects of phytoestrogen genistein in postmenopausal women.
BACKGROUND
Genistein is an isoflavone phytoestrogen derived from the soybean which acts as natural selective estrogen receptor modulator. Various studies have pointed out its cardioprotective role. The aim of the study was to evaluate the haemostatic effects of genistein in postmenopausal women.


METHODS
In this double-blind placebo-controlled trial we enrolled 104 healthy postmenopausal women with osteopenia. 53 patients (mean age 54.9+/-4.2 yr; BMI 23.4+/-3.2 Kg/m(2)) received genistein (54 mg/day) and 51 patients (mean age 55.4+/-4.3 yr; BMI 23.6+/-3.6 Kg/m(2)) received an identical placebo-tablet. Both groups received a calcium and vitamin D supplement. Plasma levels of D-dimer (DD), plasminogen activator inhibitor-1 (PAI-1) and prothrombin fragment 1+2 (F1+2) were measured at baseline and after 6 and 12 months of treatment.


RESULTS
Baseline characteristics of the two groups were similar. Compared with placebo, genistein decreased significantly DD (p<0.001), but did not affect PAI-1 and F 1+2 plasma levels.


CONCLUSIONS
The results of our study do not confirm effects of genistein on activation of the haemostatic system, but on the contrary the significant decrease of DD could indicate a possible cardioprotective role of genistein in postmenopausal women.
Trifiletti
A
A
Department of Internal Medicine, University of Messina, Italy.
Gaudio
A
A
Lasco
A
A
Atteritano
M
M
Scamardi
R
R
Pizzoleo
M A
MA
Morabito
N
N
Frisina
N
N
D001851:Bone Diseases, Metabolic / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010045:Outpatients; D010446:Peptide Fragments / Q000097:blood; D048789:Phytoestrogens / Q000494:pharmacology / Q000627:therapeutic use*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D017698:Postmenopause / Q000097:blood / Q000187:drug effects; D011516:Prothrombin; D016896:Treatment Outcome
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D048789:Phytoestrogens; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; C045879:prothrombin fragment 1.2; D011516:Prothrombin; D019833:Genistein