title: Glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis.
abstract: OBJECTIVE
  To analyze the expression of the glycodelin gene to better understand the molecular environment of endometriotic lesions and to elucidate the potential mechanisms that underlie the complex physiopathology of endometriosis.
  
  
  METHODS
  Prospective laboratory study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Eleven healthy fertile women and 17 patients with endometriosis in the early proliferative phase of the menstrual cycle.
  
  
  METHODS
  Endometrial biopsy specimens were obtained from the endometrium of healthy women without endometriosis (controls) and from eutopic and ectopic endometrium tissues (pelvic and ovarian endometriotic implants) of endometriosis patients.
  
  
  METHODS
  The glycodelin relative expression level by real-time polymerase chain reaction (PCR) analysis.
  
  
  RESULTS
  The glycodelin down-regulation found in the endometriotic lesions was 332.26 and 123.17-fold lower, respectively, when compared with the eutopic tissue and the control endometrium.
  
  
  CONCLUSIONS
  Glycodelin may be one of the molecules that contributes to the loss of cellular homeostasis in endometriotic lesions.
authors.affiliation: Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. jumeola@yahoo.com.br
authors.forename: Juliana
authors.initials: J
authors.lastname: Meola
authors.forename: Daniel Blassioli
authors.initials: DB
authors.lastname: Dentillo
authors.forename: Júlio César
authors.initials: JC
authors.lastname: Rosa e Silva
authors.forename: Rui Alberto
authors.initials: RA
authors.lastname: Ferriani
authors.forename: Luciana Caricati
authors.initials: LC
authors.lastname: Veiga
authors.forename: Cláudia Cristina
authors.initials: CC
authors.lastname: Paro de Paz
authors.forename: Silvana
authors.initials: S
authors.lastname: Giuliatti
authors.forename: Lúcia
authors.initials: L
authors.lastname: Martelli
mesh_terms: D000293:Adolescent; D000328:Adult; D002828:Choristoma / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D011257:Pregnancy Proteins / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins