title: Comparison of the pathogenicity in three different Korean canine parvovirus 2 (CPV-2) isolates.
abstract: Canine parvovirus type 2 (CPV-2) is a major pathogen inducing acute hemorrhagic gastroenteritis in dogs. Despite the identification of numerous CPV-2 variants (from CPV-2a to CPV-2c), the pathogenic differences among the CPV-2 variants in dogs have not been evaluated. The aim of this study was to compare the pathogenicity of CPV-2 variants (CPV-2a-I, CPV-2a-V and CPV-2b) isolated mainly from Korea. We evaluated the pathogenicity of three different CPV-2 variants, by performing clinical, hematological, serological and histopathological examinations after experimentally inoculating three types of CPV-2 variants into young puppies. We found that the overall pathogenicity of the CPV-2a variants (CPV-2a-I and 2a-V) was severer compared to the CPV-2b variant. In addition, there was no significant difference in pathogenicity between the two CPV-2a variants. Our findings indicate that there are differences in the pathogenicity of CPV-2 variants in dogs, which may be useful to understand the different pathobiology of the CPV-2 variants.
authors.affiliation: School of Veterinary Medicine, Kangwon National University, Chuncheon 201-100, Republic of Korea.
authors.forename: H-S
authors.initials: HS
authors.lastname: Moon
authors.forename: S-A
authors.initials: SA
authors.lastname: Lee
authors.forename: S-G
authors.initials: SG
authors.lastname: Lee
authors.forename: R
authors.initials: R
authors.lastname: Choi
authors.forename: S-Y
authors.initials: SY
authors.lastname: Jeoung
authors.forename: D
authors.initials: D
authors.lastname: Kim
authors.forename: C
authors.initials: C
authors.lastname: Hyun
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000276:immunology; D003967:Diarrhea / Q000401:mortality / Q000473:pathology / Q000662:veterinary / Q000821:virology; D004283:Dog Diseases / Q000401:mortality / Q000473:pathology* / Q000821:virology*; D004285:Dogs; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D006403:Hematologic Tests / Q000662:veterinary; D007723:Korea; D010322:Parvoviridae Infections / Q000401:mortality / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000145:classification / Q000276:immunology / Q000472:pathogenicity*; D010802:Phylogeny; D011897:Random Allocation
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral