title: A pilot study for human tumor/DNA banking: returned more questions than answers.
abstract: A pilot study was performed for setting up the Dokuz Eylül University Breast Tumor DNA Bank (DEUBTB) to facilitate the sharing of tumor DNA/RNA samples and related data from cases collected by collaborators specializing in the breast cancer diseases between 2004 and 2006. The pilot study aimed to provide answers for certain questions on: (1) ethical concerns (informing the volunteer for donating specimen, anonymizing the sample information, procedure on sample request), (2) obtaining and processing samples (technical issues, flowchart), (3) storing samples and their products (storing forms and conditions), (4) clinical database (which clinical data to store), (5) management organization (quality and quantity of personnel, flowchart for management relations), (6) financial issues (establishment and maintenance costs). When the bank had 64 samples, even though it is quite ready to supply samples for a research project, it revealed many questions on details that may be answered in more than one way, pointing that all biobanks need to be controlled by a higher degree of management party which develops and offers quality standards for these establishments.
authors.affiliation: Dokuz Eylül University Faculty of Medicine and Institute of Oncology, Izmir, Turkey. aydan.cavusoglu@gmail.com
authors.forename: A Celebiler
authors.initials: AC
authors.lastname: Cavuşoğlu
authors.forename: S
authors.initials: S
authors.lastname: Saydam
authors.forename: M
authors.initials: M
authors.lastname: Alakavuklar
authors.forename: T
authors.initials: T
authors.lastname: Canda
authors.forename: A
authors.initials: A
authors.lastname: Sevinç
authors.forename: Y
authors.initials: Y
authors.lastname: Kiliç
authors.forename: O
authors.initials: O
authors.lastname: Harmancioğlu
authors.forename: M A
authors.initials: MA
authors.lastname: Koçdor
authors.forename: M
authors.initials: M
authors.lastname: Kinay
authors.forename: H
authors.initials: H
authors.lastname: Alanyali
authors.forename: I
authors.initials: I
authors.lastname: Görken
authors.forename: P
authors.initials: P
authors.lastname: Balci
authors.forename: B
authors.initials: B
authors.lastname: Demirkan
authors.forename: M
authors.initials: M
authors.lastname: Sakizli
authors.forename: G
authors.initials: G
authors.lastname: Güner
mesh_terms: D001943:Breast Neoplasms; D004247:DNA; D005260:Female; D006801:Humans; D010865:Pilot Projects; D012313:RNA; D013048:Specimen Handling / Q000941:ethics / Q000379:methods / Q000592:standards; D014015:Tissue Banks / Q000941:ethics* / Q000458:organization & administration* / Q000592:standards*; D014421:Turkey
chemical_list: D012313:RNA; D004247:DNA