[Nephrogenic systemic fibrosis: another problem for patients with chronic renal failure].
Nephrogenic systemic fibrosis, another problem for patients with chronic renal failure Nephrogenic systemic fibrosis is a rare but severe disease described in patients with kidney failure. High morbidity ant mortality are associated with this new condition. Epidemiological studies strongly suggest a link between nephrogenic systemic fibrosis and gadolinium administration for magnetic resonance imaging enhancement. The disease is primarily cutaneous, with oedema affecting the limbs, later evolving to fibrosis that leads to joints contractures. The lesions can spread to the trunk and involve systemic organs like the heart, lungs and muscles. Given the lack of proved efficient therapy, careful evaluation of the risks and benefits of gadolinium administration should be done in patients with kidney disease. If really needed, a highly stable contrast media should be used.
Michelet
P-R
PR
Service de médecine interne générale, HUG, 1211 Genève 14. Pierre-Raphael.Michelet@hcuge.ch
Chopard
C Stoermann
CS
Martin
P-Y
PY
Vallée
J-P
JP
D003287:Contrast Media / Q000009:adverse effects; D005355:Fibrosis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D019786:Gadolinium DTPA / Q000009:adverse effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008279:Magnetic Resonance Imaging
D003287:Contrast Media; D019786:Gadolinium DTPA