title: [Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion].
abstract: OBJECTIVE
  To test the effect of Tanshinone II A nanoparticles on the expression of MMP-2.
  
  
  METHODS
  Thirty five male New Zealand white rabbits were randomly divided into three groups. In group A (15 rabbits), the carotid arteries of the rabbits were stripped. In group B (5 rabbits) and C (15 rabbits), nanoparticles and Tanshinone II A nanoparticles were perfused respectively in the denudated arteries of the rabbits. The neointimal areas and the IOD values of MMP-2 secretion were measured.
  
  
  RESULTS
  A significant reduction of neointimal hyperplasia in group C was found compared to the other two groups in terms of the intimal area and the intima-media ratio. Group C had significant lower IOD values than group A.
  
  
  CONCLUSIONS
  Local administration of nanoparticles with incorporated Tanshinone I A not only inhibits neointimal hyperplasia but also inhibits the expression of MMP-2 in stripped arteries.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liang
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xie
authors.forename: Su-Bin
authors.initials: SB
authors.lastname: Xiong
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Zhia
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D045784:Abietanes; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006965:Hyperplasia / Q000378:metabolism; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D053758:Nanoparticles; D010616:Phenanthrenes / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D045784:Abietanes; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C021751:tanshinone; D020778:Matrix Metalloproteinase 2