Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt.
First synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt is reported.
Risbood
Prabhakar A
PA
Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. risboodp@mail.nih.gov
Kane
Charles T
CT
Hossain
Md Tafazzal
MT
Vadapalli
Sudhakarrao
S
Chadda
Satish K
SK
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008956:Models, Chemical; D011122:Polyphosphates / Q000138:chemical synthesis / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D012492:Salts / Q000737:chemistry / Q000494:pharmacology*; D014325:Tromethamine / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D011122:Polyphosphates; D000644:Quaternary Ammonium Compounds; D012492:Salts; D014325:Tromethamine; D003841:Deoxycytidine; C005692:triphosphoric acid; D000093542:Gemcitabine