title: Endoglin (CD105): a marker of tumor vasculature and potential target for therapy.
abstract: Endoglin (CD105) is an accessory protein of the transforming growth factor-beta receptor system expressed on vascular endothelial cells. Mutation of the endoglin gene is associated with hereditary hemorrhagic telangiectasias, or Osler-Weber-Rendu syndrome, and has been studied extensively in the context of this disease. The expression of endoglin is elevated on the endothelial cells of healing wounds, developing embryos, inflammatory tissues, and solid tumors. Endoglin is a marker of activated endothelium, and its vascular expression is limited to proliferating cells. Recent studies identified endoglin expression in several solid tumor types, with the level of expression correlating with various clinicopathologic factors including decreased survival and presence of metastases. Attempts to target endoglin and the cells that express this protein in tumor-bearing mice have yielded promising results.
authors.affiliation: Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230-1402, USA.
authors.forename: Nikolaos A
authors.initials: NA
authors.lastname: Dallas
authors.forename: Shaija
authors.initials: S
authors.lastname: Samuel
authors.forename: Ling
authors.initials: L
authors.lastname: Xia
authors.forename: Fan
authors.initials: F
authors.lastname: Fan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gray
authors.forename: Sherry J
authors.initials: SJ
authors.lastname: Lim
authors.forename: Lee M
authors.initials: LM
authors.lastname: Ellis
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D000071063:Endoglin; D042783:Endothelial Cells / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta