title: Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
abstract: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
authors.affiliation: Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden.
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Li
authors.forename: Elisabet
authors.initials: E
authors.lastname: Englund
authors.forename: Janice L
authors.initials: JL
authors.lastname: Holton
authors.forename: Denis
authors.initials: D
authors.lastname: Soulet
authors.forename: Peter
authors.initials: P
authors.lastname: Hagell
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
authors.forename: Tammaryn
authors.initials: T
authors.lastname: Lashley
authors.forename: Niall P
authors.initials: NP
authors.lastname: Quinn
authors.forename: Stig
authors.initials: S
authors.lastname: Rehncrona
authors.forename: Anders
authors.initials: A
authors.lastname: Björklund
authors.forename: Håkan
authors.initials: H
authors.lastname: Widner
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.forename: Olle
authors.initials: O
authors.lastname: Lindvall
authors.forename: Patrik
authors.initials: P
authors.lastname: Brundin
mesh_terms: D016380:Brain Tissue Transplantation / Q000379:methods / Q000473:pathology*; D018450:Disease Progression; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology*; D010300:Parkinson Disease / Q000628:therapy*; D016896:Treatment Outcome; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein