title: Hormonal contraception and HIV prevalence in four African countries.
abstract: BACKGROUND
  The HIV seroprevalence among women aged 15-24 years was compared according to their pattern of contraceptive use in four African countries: Kenya, Lesotho, Malawi and Zimbabwe.
  
  
  METHODS
  Data were derived from Demographic and Health Surveys (DHS) conducted between 2003 and 2006 on representative samples, totaling 4549 women.
  
  
  RESULTS
  It is indicated that users of depo-medroxyprogesterone acetate (DMPA) have a significantly higher seroprevalence than nonusers [odds ratio (OR)=1.82, 95% CI=1.63-2.03] and higher than users of oral contraceptives and users of traditional methods. The results were confirmed in a multivariate analysis including as controls, age, duration since first intercourse, urban residence, education, number of sexual partners in the last 12 months and marital status. A somewhat smaller net effect (OR=1.34, 95% CI=1.10-1.63) was found. In contrast, oral contraceptives and traditional methods did not show any risk for HIV (OR=0.96 and 0.92, respectively).
  
  
  CONCLUSIONS
  The increased risk of DMPA was present in three of the four countries investigated, and significant in Zimbabwe and Lesotho, the countries with the highest HIV seroprevalence. The HIV risk attributable to DMPA remained small altogether and was estimated as 6% in the four countries combined.
authors.affiliation: Epidémiologie des Maladies Emergentes, Institut Pasteur, 25 rue du Docteur Roux, Paris, France. leclerc@pasteur.fr
authors.forename: Pauline M
authors.initials: PM
authors.lastname: Leclerc
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dubois-Colas
authors.forename: Michel
authors.initials: M
authors.lastname: Garenne
mesh_terms: D000293:Adolescent; D000328:Adult; D000349:Africa; D003271:Contraceptive Agents, Female / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D015528:HIV Seroprevalence; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate