Cancer immunosurveillance: NKG2D breaks cover.
The idea of cancer immunosurveillance has regained interest in recent years. In this issue of Immunity, Guerra et al. (2008) present the first genetic evidence for surveillance of primary tumors by a natural killer cell-associated receptor.
Ljunggren
Hans-Gustaf
HG
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 14186 Stockholm, Sweden. hans-gustaf.ljunggren@ki.se
D000818:Animals; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic / Q000235:genetics; D005786:Gene Expression Regulation / Q000276:immunology; D007157:Immunologic Surveillance / Q000235:genetics; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D055655:NK Cell Lectin-Like Receptor Subfamily K; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D055607:Receptors, Natural Killer Cell
C527086:Klrk1 protein, mouse; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell