title: [Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases].
abstract: Pudendal nerve block may be indicated during instrumental delivery in situations where peridural anesthesia is unavailable. We report three cases of neonatal lidocaine intoxication following maternal pudendal block during delivery. Clinical features were hypotonia, pupillary mydriasis fixed to light, apnea, cyanosis and seizures. Two neonates required mechanical ventilation. Lidocaine was found in the serum of two babies. In all three cases, recovery was complete. The pharmacokinetics of lidocaine in a highly vascularized perineum during labor increase the risk of neonatal intoxication. A possible intoxication by local anesthetics should be considered in neonates presenting an acute distress in the delivery room.
authors.affiliation: Service de néonatalogie, CHRU, avenue Georges-Clémenceau, 14033 Caen cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Pagès
authors.forename: B
authors.initials: B
authors.lastname: de la Gastine
authors.forename: J
authors.initials: J
authors.lastname: Quedru-Aboane
authors.forename: M-G
authors.initials: MG
authors.lastname: Guillemin
authors.forename: V
authors.initials: V
authors.lastname: Lelong-Boulouard
authors.forename: B
authors.initials: B
authors.lastname: Guillois
mesh_terms: D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000097:blood; D001049:Apnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D009123:Muscle Hypotonia / Q000139:chemically induced; D015878:Mydriasis / Q000139:chemically induced; D009407:Nerve Block; D011247:Pregnancy; D012640:Seizures / Q000139:chemically induced
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine