title: Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog.
abstract: Canine anal sac gland carcinoma (ASGC) is a frequently described neoplasm that is highly aggressive and can frequently lead to metastatic spread. In this paper, we describe the successful treatment of an incompletely excised ASGC by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog received two courses of electrochemotherapy 14 days apart. Neither systemic nor local toxicities were detected during the whole course of therapy. The dog is still in complete remission after 18 months. Electrochemotherapy is a safe and efficacious adjuvant therapy for ASGC and warrants further investigation in order to standardize its protocols.
authors.affiliation: S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy. info@enricospugnini.net
authors.forename: Enrico P
authors.initials: EP
authors.lastname: Spugnini
authors.forename: Ivan
authors.initials: I
authors.lastname: Dotsinsky
authors.forename: Nikolay
authors.initials: N
authors.lastname: Mudrov
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bufalini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Giannini
authors.forename: Gennaro
authors.initials: G
authors.lastname: Citro
authors.forename: Florinda
authors.initials: F
authors.lastname: Feroce
authors.forename: Alfonso
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000694:Anal Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000695:Anal Sacs / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D053672:Electrochemotherapy; D008297:Male; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin