title: First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
abstract: Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.
authors.affiliation: JMI Laboratories, North Liberty, IA 52317, USA.
authors.forename: Rodrigo E
authors.initials: RE
authors.lastname: Mendes
authors.forename: Lalitagauri M
authors.initials: LM
authors.lastname: Deshpande
authors.forename: Mariana
authors.initials: M
authors.lastname: Castanheira
authors.forename: Joseph
authors.initials: J
authors.lastname: DiPersio
authors.forename: Michael A
authors.initials: MA
authors.lastname: Saubolle
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D000069349:Linezolid; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D023303:Oxazolidinones / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D023303:Oxazolidinones; D008780:Methyltransferases; D000069349:Linezolid