Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats.
The effect of Eriobotrya japonica seed extract (ESE) prepared with 70% ethanol on gastric mucosal injury was investigated. Six experimental models with different action mechanisms were used for the evaluation. Three concentrations of ESE were prepared for each model. ESE administration was initiated 14 days before induction of gastric mucosal injury, and its effect was investigated. ESE inhibited formation of gastric mucosal injury.
Yokota
Junko
J
Japan Science and Technology Agency, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan. jm-yokotaj@kochi-u.ac.jp
Takuma
Daisuke
D
Hamada
Atsuhide
A
Onogawa
Masahide
M
Yoshioka
Saburo
S
Kusunose
Masahiko
M
Miyamura
Mitsuhiko
M
Kyotani
Shojiro
S
Nishioka
Yutaka
Y
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D031983:Eriobotrya / Q000737:chemistry; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005765:Gastrointestinal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009093:Mucus / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
D005765:Gastrointestinal Agents; D010936:Plant Extracts; D020011:Protective Agents