title: Effects of high dietary molybdenum in rabbits.
abstract: To study the effects of high dietary molybdenum (Mo) content, rabbits were fed with commercial pellets and carrots containing 39 mg Mo/kg dry matter (DM) [Experiment 1] and with a commercial diet supplemented with 40 mg Mo/kg DM [Experiment 2] for 14 days. The high dietary Mo contents failed to reduce the growth performance of rabbits. Moreover, supplemental Mo given in a dose of 40 mg/kg non-significantly decreased the apparent digestibility of crude protein (CP) and crude fibre (CF) compared to the control (73.63 +/- 2.49 and 18.56 +/- 5.10 vs. 74.31 +/- 3.03 and 21.38 +/- 6.48, respectively). Molybdenum ingested with feeds was mainly excreted (57%) via the urine. The highest Mo levels were found in kidney and liver samples (3.464 +/- 0.872; 5.27 +/- 0.95 mg/kg DM [Experiment 1] and 1.878 +/- 0.283; 1.62 +/- 0.16 mg/kg DM [Experiment 2], respectively), and Mo could also be detected in limb meat (0.336 +/- 0.205 mg/kg DM). It was stated that the testes were more sensitive to Mo exposure than the female reproductive organs because the number of germ cells was reduced. Due to the high dietary Mo intake free radicals could be generated, resulting in a marked increase of creatine kinase (CK) activity.
authors.affiliation: Department of Animal Breeding, Nutrition and Laboratory Animal Science, Faculty of Veterinary Science, Szent István University, H-1400 Budapest, P.O. Box 2, Hungary. Bersenyi.Andras@aotk.szie.hu
authors.forename: András
authors.initials: A
authors.lastname: Bersényi
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Berta
authors.forename: István
authors.initials: I
authors.lastname: Kádár
authors.forename: Róbert
authors.initials: R
authors.lastname: Glávits
authors.forename: Mihály
authors.initials: M
authors.lastname: Szilágyi
authors.forename: Sándor György
authors.initials: SG
authors.lastname: Fekete
mesh_terms: D000273:Adipose Tissue; D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight; D001842:Bone and Bones; D004032:Diet / Q000662:veterinary*; D004063:Digestion; D004435:Eating; D005260:Female; D006197:Hair; D006321:Heart; D007668:Kidney; D008099:Liver; D008168:Lung; D008297:Male; D008982:Molybdenum / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D018482:Muscle, Skeletal; D010053:Ovary; D011817:Rabbits; D013737:Testis; D014018:Tissue Distribution
chemical_list: D008982:Molybdenum