title: Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1.
abstract: Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (Delta vhs). Delta vhs virus-infected Stat1(-/-) mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1(-/-) mice. Stat1 deficiency relieves the immunomodulatory deficiency of Delta vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation.
authors.affiliation: Washington University School of Medicine, Department of Ophthalmology and Visual Sciences, 660 South Euclid Ave., St. Louis, MO 63110, USA.
authors.forename: Tracy Jo
authors.initials: TJ
authors.lastname: Pasieka
authors.forename: Betty
authors.initials: B
authors.lastname: Lu
authors.forename: David A
authors.initials: DA
authors.lastname: Leib
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D018345:Mice, Knockout; D050794:STAT1 Transcription Factor / Q000235:genetics*; D018139:Simplexvirus / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence; D017735:Virus Latency; D014779:Virus Replication
chemical_list: D050794:STAT1 Transcription Factor; C494080:Stat1 protein, mouse