title: Aging of the immune system as a prognostic factor for human longevity.
abstract: Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.
authors.affiliation: University of Tübingen, Center for Medical Research,Tübingen, Germany. anis.larbi@medizin.uni-tuebingen.de
authors.forename: Anis
authors.initials: A
authors.lastname: Larbi
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.forename: Dawn
authors.initials: D
authors.lastname: Mazzatti
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana
authors.forename: Anders
authors.initials: A
authors.lastname: Wikby
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
mesh_terms: D000375:Aging / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008136:Longevity / Q000276:immunology*; D011379:Prognosis