title: MR imaging-based decision in thrombolytic therapy for stroke on awakening: report of 2 cases.
abstract: Patients with stroke on awakening are denied the potential benefit of thrombolysis on the grounds that the onset time is unknown. Relying on clinical and MR imaging to indicate the most appropriate treatment could be more rational. We report 2 cases of stroke with unknown onset time. In both cases, anamnesis and MR imaging indicated that we might still be within 6 hours from stroke onset, with salvageable tissue. Arterial recanalization was successfully performed in both cases.
authors.affiliation: Department of Neuroradiology, Université Paris Descartes, Centre Hospitalier Sainte-Anne, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Iosif
authors.forename: C
authors.initials: C
authors.lastname: Oppenheim
authors.forename: D
authors.initials: D
authors.lastname: Trystram
authors.forename: V
authors.initials: V
authors.lastname: Domigo
authors.forename: J-F
authors.initials: JF
authors.lastname: Méder
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000188:drug therapy*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis; D012890:Sleep / Q000502:physiology*; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome; D014851:Wakefulness / Q000502:physiology*
chemical_list: D010959:Tissue Plasminogen Activator