title: Patients with the metabolic syndrome and a disturbed cortisol balance display more microalbuminuria.
abstract: The objective of this study was to investigate whether patients with the metabolic syndrome (MetS) and an imbalance in cortisol metabolism express increased urinary albumin excretion compared to those patients with metabolic syndrome alone. Seventy-four patients with MetS were evaluated using a low-dose dexamethasone suppression test (LDDST) to identify disturbed cortisol balance (cortisol levels > 50 nmol/L after LDDST). The level of albumin in the urine was also evaluated. Disturbed cortisol balance was found in 8% of all evaluated patients with MetS. Microalbuminuria was present significantly more often (p<0.01) in those patients with MetS and an imbalance in cortisol metabolism compared with patients suffering MetS alone (urine albumin: 210 mg/L vs. 26 mg/L, respectively, p<0.01). A substantial percentage of patients with MetS had inappropriate cortisol homeostasis. Of importance, excretion of urinary albumin was increased in these patients. This observation may indicate that this subgroup within the MetS population has a higher cardiovascular risk and possible increased endothelial dysfunction, with a subsequent need for stricter control to prevent cardiovascular morbidity and mortality.
authors.affiliation: Department of Cardiology, University Medical Centre (UMC) Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. sarah_jans@hotmail.com
authors.forename: Sarah F
authors.initials: SF
authors.lastname: Janssen
authors.forename: Theodorus B
authors.initials: TB
authors.lastname: Twickler
authors.forename: Christel
authors.initials: C
authors.lastname: Jublanc
authors.forename: Maarten J
authors.initials: MJ
authors.lastname: Cramer
authors.forename: Eric
authors.initials: E
authors.lastname: Bruckert
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000150:complications*; D000419:Albuminuria / Q000209:etiology*; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D006854:Hydrocortisone