title: Adsorption of insulin onto infusion sets used in adult intensive care unit and neonatal care settings.
abstract: BACKGROUND
  Insulin adsorption onto infusion equipment may affect glycaemic control.
  
  
  METHODS
  The change in insulin concentration during delivery through tubing employed for adult ICU and neonatal patients was determined using continuous flow UV analysis.
  
  
  RESULTS
  Insulin adsorption depended on tubing composition, dimensions and flow rate, being highest for neonatal polyvinylchloride tubing at low flow rates.
  
  
  CONCLUSIONS
  In continuous insulin therapy, we should consider the nature of the infusion set and flow rate.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Najam
authors.initials: N
authors.lastname: Zahid
authors.forename: Kevin M G
authors.initials: KM
authors.lastname: Taylor
authors.forename: Hardyal
authors.initials: H
authors.lastname: Gill
authors.forename: Fiona
authors.initials: F
authors.lastname: Maguire
authors.forename: Rob
authors.initials: R
authors.lastname: Shulman
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use*; D061389:Insulin, Regular, Pork; D007362:Intensive Care Units; D007363:Intensive Care Units, Neonatal
chemical_list: D001786:Blood Glucose; D007328:Insulin; D061389:Insulin, Regular, Pork; C000006:insulin, neutral