Bruton and Tec: new links in osteoimmunology.
Enhanced and deficient immune responses are associated with abnormal bone homeostasis. A new study by Shinohara et al. (2008) shows that protein phosphorylation by the tyrosine kinases Bruton and Tec links immunity and bone as well as two signaling pathways in precursors of osteoclasts, the cells that degrade bone.
Boyce
Brendan F
BF
University of Rochester Medical Center, University of Rochester, Rochester, NY 14534, USA. brendan_boyce@urmc.rochester.edu
Xing
Lianping
L
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001842:Bone and Bones / Q000166:cytology* / Q000201:enzymology / Q000276:immunology*; D002454:Cell Differentiation; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*
C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625951:Btk protein, mouse