[Distribution of tryptophan hydroxylase gene-T457C locus polymorphism in Han ethnic group in northern China].
OBJECTIVE
To study the distribution of the tryptophan hydroxylase (TPH) gene-T457C locus polymorphism in Han ethnic group in northern China and to find its applicable value in forensic science.


METHODS
Genomic DNA samples, extracted from 180 unrelated individuals in northern Chinese Han population, were analyzed by PCR-RFLP.


RESULTS
The discrimination power (DP) value and the power of exclusion (PE) value of the TPH gene-T457C locus were 0.624 and 0.187, respectively. The allele frequency showed significant difference from that of French people (P=0.04).


CONCLUSIONS
Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. It has a potential to be used in forensic science.
Guan
Hong-Yu
HY
School of Forensic Medicine, China Medical University, Shenyang, China.
Wang
Bao-Jie
BJ
Ding
Mei
M
Pang
Hao
H
Wang
Bin
B
Lu
Hong-Tao
HT
Xing
Jia-Xin
JX
Yi
Jin-Feng
JF
Li
Chun-Mei
CM
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D014365:Tryptophan Hydroxylase