title: Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study.
abstract: OBJECTIVE
  To test the feasibility of and interactions among three software-driven critical care protocols.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Intensive care units in six European and American university hospitals.
  
  
  METHODS
  174 cardiac surgery and 41 septic patients.
  
  
  METHODS
  Application of software-driven protocols for cardiovascular management, sedation, and weaning during the first 7 days of intensive care.
  
  
  RESULTS
  All protocols were used simultaneously in 85% of the cardiac surgery and 44% of the septic patients, and any one of the protocols was used for 73 and 44% of study duration, respectively. Protocol use was discontinued in 12% of patients by the treating clinician and in 6% for technical/administrative reasons. The number of protocol steps per unit of time was similar in the two diagnostic groups (n.s. for all protocols). Initial hemodynamic stability (a protocol target) was achieved in 26+/-18 min (mean+/-SD) in cardiac surgery and in 24+/-18 min in septic patients. Sedation targets were reached in 2.4+/-0.2h in cardiac surgery and in 3.6 +/-0.2h in septic patients. Weaning protocol was started in 164 (94%; 154 extubated) cardiac surgery and in 25 (60%; 9 extubated) septic patients. The median (interquartile range) time from starting weaning to extubation (a protocol target) was 89 min (range 44-154 min) for the cardiac surgery patients and 96 min (range 56-205 min) for the septic patients.
  
  
  CONCLUSIONS
  Multiple software-driven treatment protocols can be simultaneously applied with high acceptance and rapid achievement of primary treatment goals. Time to reach these primary goals may provide a performance indicator.
authors.affiliation: Department of Intensive Care Medicine, Bern University Hospital, 3010, Bern, Switzerland. jukka.takala@insel.ch
authors.forename: Jukka
authors.initials: J
authors.lastname: Takala
authors.forename: R Philip
authors.initials: RP
authors.lastname: Dellinger
authors.forename: Kati
authors.initials: K
authors.lastname: Koskinen
authors.forename: Arthur
authors.initials: A
authors.lastname: St Andre
authors.forename: Martyn
authors.initials: M
authors.lastname: Read
authors.forename: Mitchell
authors.initials: M
authors.lastname: Levy
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Jakob
authors.forename: Patricia Veiga C
authors.initials: PV
authors.lastname: Mello
authors.forename: Raymond
authors.initials: R
authors.lastname: Friolet
authors.forename: Esko
authors.initials: E
authors.lastname: Ruokonen
mesh_terms: D018806:APACHE; D000368:Aged; D000465:Algorithms; D002318:Cardiovascular Diseases / Q000628:therapy*; D002985:Clinical Protocols; D003422:Critical Care / Q000592:standards* / Q000706:statistics & numerical data; D005060:Europe; D005240:Feasibility Studies; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007902:Length of Stay; D008875:Middle Aged; D018805:Sepsis / Q000628:therapy*; D013813:Therapy, Computer-Assisted / Q000706:statistics & numerical data*; D013903:Thoracic Surgery / Q000706:statistics & numerical data*; D014481:United States; D015300:Ventilator Weaning