title: Subclinical cardiac abnormalities in human immunodeficiency virus-infected men receiving antiretroviral therapy.
abstract: Although cardiotoxic effects of highly active antiretroviral therapy (HAART) are a growing concern, there is a lack of prospective studies of subclinical involvement of the heart in human immunodeficiency virus (HIV)-infected patients. This study evaluated noninvasively cardiac morphologic characteristics and function in HIV-positive (HIV(+)) men receiving HAART for > or =2 years with no clinical evidence of cardiovascular disease. Echocardiography at rest, including tissue Doppler imaging and exercise testing, were performed in 30 HIV(+) men (age 42.1 +/- 4.7 years, duration of HIV infection 10.4 +/- 4.7 years, duration of HAART 5.3 +/- 2.1 years) and 26 age-matched healthy controls. At rest, HIV(+) patients had similar left ventricular (LV) mass indexed to height(2.7) (40.6 +/- 9.5 vs 37.5 +/- 9.3 g/m; p >0.05), but a higher prevalence of LV diastolic dysfunction (abnormal relaxation or pseudonormal filling pattern in 64% of patients vs 12% of controls; p <0.001). LV systolic function indexes were significantly lower (ejection fraction 60.4 +/- 8.7% vs 66.9 +/- 6.9%; p <0.01, and tissue Doppler imaging peak systolic velocity 11.4 +/- 1.6 vs 13.5 +/- 2.2 cm/s; p <0.001). Pulmonary artery pressure was higher in patients compared with controls (32.1 +/- 5.4 vs 26.1 +/- 6.5 mm Hg; p <0.001). Exercise testing showed decreased exercise tolerance in HIV(+) patients, with no case of myocardial ischemia. In conclusion, subclinical cardiac abnormalities are frequently observed in HIV(+) patients on HAART. The usefulness of systematic noninvasive screening in this population should be considered. GECEM study no. 30: National Agency for AIDS Research (ANRS).
authors.affiliation: Cardiology Department, University Hospital Carémeau, Nîmes, France.
authors.forename: Iris
authors.initials: I
authors.lastname: Schuster
authors.forename: Gilles Jacques
authors.initials: GJ
authors.lastname: Thöni
authors.forename: Stéphane
authors.initials: S
authors.lastname: Edérhy
authors.forename: Guillaume
authors.initials: G
authors.lastname: Walther
authors.forename: Stéphane
authors.initials: S
authors.lastname: Nottin
authors.forename: Agnès
authors.initials: A
authors.lastname: Vinet
authors.forename: Franck
authors.initials: F
authors.lastname: Boccara
authors.forename: Mohamed
authors.initials: M
authors.lastname: Khireddine
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Mauboussin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouanet
authors.forename: Michel
authors.initials: M
authors.lastname: Dauzat
authors.forename: Ariel
authors.initials: A
authors.lastname: Cohen
authors.forename: Patrick
authors.initials: P
authors.lastname: Messner-Pellenc
authors.forename: Philippe
authors.initials: P
authors.lastname: Obert
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012146:Rest / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*