title: Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice.
abstract: Neurogenesis proceeds throughout adulthood in the brain of most mammalian species, but the molecular mechanisms underlying the regulation of stem/progenitor cell proliferation, survival, maturation, and differentiation have not been completely unraveled. We have studied hippocampal neurogenesis in NF-kappaB p50-deficient mice. Here we demonstrate that in absence of p50, the net rate of neural precursor proliferation does not change, but some of the steps leading to the final neuron differentiation status are hampered, resulting in approximately 50% reduction in the number of newly born neurons in the adult mutant hippocampus. Additionally, in p50(-/-) mice, we observed a selective defect in short-term spatial memory performance without impairment of hippocampal-dependent spatial long-term memory and learning. Our results highlight the role of NF-kappaB p50 in hippocampal neurogenesis and in short-term spatial memory.
authors.affiliation: Department of Biology, Section of Zoology and Cytology, University of Milan and Neuroscience Institute, National Research Council, Milan 20100, Italy.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Denis-Donini
authors.forename: Anna
authors.initials: A
authors.lastname: Dellarole
authors.forename: Paola
authors.initials: P
authors.lastname: Crociara
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Francese
authors.forename: Valeria
authors.initials: V
authors.lastname: Bortolotto
authors.forename: Giorgia
authors.initials: G
authors.lastname: Quadrato
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Canonico
authors.forename: Marco
authors.initials: M
authors.lastname: Orsetti
authors.forename: Piera
authors.initials: P
authors.lastname: Ghi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Memo
authors.forename: Sara Anna
authors.initials: SA
authors.lastname: Bonini
authors.forename: Giulia
authors.initials: G
authors.lastname: Ferrari-Toninelli
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Grilli
mesh_terms: D000375:Aging; D000818:Animals; D001973:Bromodeoxyuridine; D002452:Cell Count; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D006624:Hippocampus / Q000254:growth & development* / Q000473:pathology; D007858:Learning; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology*; D008570:Memory, Short-Term; D051379:Mice; D018345:Mice, Knockout; D052002:NF-kappa B p50 Subunit / Q000172:deficiency*; D009474:Neurons / Q000473:pathology; D013234:Stem Cells / Q000473:pathology
chemical_list: D052002:NF-kappa B p50 Subunit; D001973:Bromodeoxyuridine