title: [Birth defects, medical outcome and somatic development in children conceived after intracytoplasmic sperm injection (ICSI)].
abstract: OBJECTIVE
  To analyze the incidence of birth defects, medical outcome and somatic development in children conceived after intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Prospective open cross-sectional clinical study.
  
  
  METHODS
  University hospital and private IVF unit.
  
  
  METHODS
  135 Czech children (59 girls, 76 boys) from singleton and twin pregnancies conceived after ICSI (age 03-9.5 years; median 5.9) were assessed during the period 2004-2006. The incidence of birth defects, medical outcome and somatic development were evaluated and compared with data of general population and/or with control group matched for sex and age.
  
  
  RESULTS
  Birth defects were found in 133% of ICSI children (compared to 4.6% in children after spontaneous conception; p<0.001). The general health of ICSI children did not differ significantly compared to general population. ICSI children required more surgery or hospitalization compared to general population data. There is high rate (69.6%) among ICSI children in the care of various specialised clinics. Body height and weight in ICSI children is in normal range and corresponds to their growth potential. Head circumference in ICSI children is larger compared to reference data (0.43 SD; p<0.001).
  
  
  CONCLUSIONS
  No clinically important differences in somatic development between ICSI and general population of Czech children were found. Birth defects were more frequent in ICSI children. The overall general health in ICSI children seems satisfactory but ICSI children were more likely to need health care compared to general population.
authors.affiliation: Pediatrická klinika 2. LF UK a FN Motol, Praha. marta.snajderova@lfmotol.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Snajderová
authors.forename: D
authors.initials: D
authors.lastname: Zemková
authors.forename: T
authors.initials: T
authors.lastname: Mardesić
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: V
authors.initials: V
authors.lastname: Gregor
authors.forename: D
authors.initials: D
authors.lastname: Krejcírová
authors.forename: D
authors.initials: D
authors.lastname: Sobotková
authors.forename: J
authors.initials: J
authors.lastname: Kraus
authors.forename: V
authors.initials: V
authors.lastname: Lánská
mesh_terms: D002648:Child; D002657:Child Development; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000453:epidemiology; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D008297:Male; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects