title: The sensitivity and specificity of thermometry and plethysmography in the assessment of hand-arm vibration syndrome.
abstract: BACKGROUND
  Finger plethysmography and thermometry are objective measures used to assess the vascular aspect of hand-arm vibration syndrome (HAVS). Research to date shows poor correlation between these tests and Stockholm Workshop Scale (SWS) vascular stage. Clinicians, researchers and compensation boards require objective means to diagnose and quantify HAVS.
  
  
  OBJECTIVE
  To define the specificity and sensitivity of thermometry and plethysmography using the SWS as the reference criterion. A secondary goal was to consider cut points for the tests optimizing sensitivity and specificity.
  
  
  METHODS
  A cross-sectional analysis was conducted on HAVS patients seen at an occupational medicine specialty clinic. Plethysmography and thermometry were analyzed using SWS vascular stage as the outcome variable. Logistic regression controlled for age, smoking and time since last vibration exposure and use of vasoactive medications. The sensitivity and specificity of the combined tests were calculated using varying cut points.
  
  
  RESULTS
  A total of 139 patients consented to participate in the study. Plethysmography stage 1 or greater showed the highest sensitivity (sensitivity 94% and specificity 15%). Specificity was optimized combining plethysmography stage 3 and thermometry stage 3 (specificity 98% and sensitivity 23%). Maximal diagnostic accuracy was achieved by plethysmography alone setting the criteria for a positive test as being stage 1 or greater (70%).
  
  
  CONCLUSIONS
  Neither plethysmography nor thermometry either alone or in combination demonstrated sufficient sensitivity and specificity to serve as an objective correlate for SWS vascular stage. All combinations of plethysmography and thermometry showed a lower specificity than sensitivity indicating that the SWS may be less sensitive in detecting vascular pathology than the objective tests.
authors.affiliation: Department of Occupational and Environmental Health, St Michael's Hospital, 30 Bond Street, 4th Floor Shuter Wing, Toronto, Ontario M5B1W8, Canada. aaron.thompson@utoronto.ca
authors.forename: Aaron
authors.initials: A
authors.lastname: Thompson
authors.forename: Ron
authors.initials: R
authors.lastname: House
authors.forename: Michael
authors.initials: M
authors.lastname: Manno
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005385:Fingers; D053421:Hand-Arm Vibration Syndrome / Q000175:diagnosis*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010991:Plethysmography; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012881:Skin Temperature; D055815:Young Adult