title: Lipid-rich carcinoma of the breast: a case report.
abstract: Lipid-rich carcinoma is a rare variant and accounts for < or = 2% of all breast cancer diagnoses. We report a case occurring in a 53-year-old female. The patient presented with a painless, right breast mass. Clinical examination and mammography suggested malignancy. Subsequent modified radical mastectomy revealed the diagnosis of lipid-rich carcinoma. The morphological features, differential diagnosis and treatment along with a brief review of the literature are discussed in this article. Lipid-rich carcinoma (L-RC) is a very rare variant of breast carcinomas with an aggressive clinical course and poor prognosis. It presents only 1% to 2% of all breast cases. It is classified as a specific variety of mammary carcinoma because the tumour cells possess abundant vacuolated cytoplasm which is strongly positive when stained for neutral fat. Aboumrad first described it in 1963 as lipid-secreting carcinoma. However, Ramos and Taylor renamed it as lipid-rich breast carcinoma. In China, the first case was reported in 1984. Herein, we report a case of lipid-rich carcinoma occurring in a 53-year-old female patient, and the literature is reviewed.
authors.affiliation: Department of General Surgery, Shandong Provincial Hospital, Shandong Unniversity, Jinan 250021, China.
authors.forename: P
authors.initials: P
authors.lastname: Shi
authors.forename: R
authors.initials: R
authors.lastname: Ma
authors.forename: H D
authors.initials: HD
authors.lastname: Gao
authors.forename: L Y
authors.initials: LY
authors.lastname: Jiang
authors.forename: J Z
authors.initials: JZ
authors.lastname: Sun
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008055:Lipids / Q000032:analysis; D008875:Middle Aged
chemical_list: D008055:Lipids; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil