title: Relationship between cell adhesion molecules expression and the biological behavior of gastric carcinoma.
abstract: OBJECTIVE
  To evaluate the relationship between the expression of cell adhesion molecules (CAMs) and the biological behavior of gastric carcinoma.
  
  
  METHODS
  Expression of syndecan-1, E-cadherin and integrin beta3 were evaluated by immunohistochemical study in a total of 118 gastric carcinomas and 20 non-tumor gastric mucosas.
  
  
  RESULTS
  The expressions of syndecan-1 and E-cadherin were significantly lower in gastric carcinoma compared to non-tumor gastric mucosa, and the low expression rates were positively correlated to the tumor invasion depth, vessel invasion, lymph node metastasis and distant metastasis (P < 0.01 in all cases). However, the expression of integrin beta3 was significantly higher in gastric carcinoma compared to non-tumor gastric mucosa, and the high expression rates were positively correlated to the tumor invasion depth, vessel invasion, lymph node metastasis and distant metastasis (P < 0.01 in all cases). In addition, the three protein expressions were correlated to the tumor growth pattern (P < 0.01, P < 0.01, and P < 0.05 respectively), but not correlated to tumor differentiation (P > 0.05, P > 0.05 and P > 0.05 respectively). Positive correlation was observed between the expressions of syndecan-1 and E-cadherin, but they which were negatively correlated to the expression of integrin beta3 (P < 0.01 in all cases). Univariate analysis demonstrated that the mean survival time and 5-year survival rate were lower in the cases with low expressions of syndecan-1 and E-cadherin and high expression of integrin beta3 (P < 0.01, in all cases). COX multivariate analysis showed that the expression level of syndecan-1 could be an independent prognostic index of gastric carcinoma (P < 0.01), whereas E-cadherin and integrin beta3 could not be independent indexes (P > 0.05, P > 0.05 respectively).
  
  
  CONCLUSIONS
  The low expression of syndecan-1 and E-cadherin and the high expression of integrin beta3 are significantly correlated with the invasion and metastasis of gastric carcinoma, and they are highly correlated with each other. Therefore they may serve as important prognostic markers of gastric carcinoma.
authors.affiliation: Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China.
authors.forename: Yong-Quan
authors.initials: YQ
authors.lastname: Chu
authors.forename: Zai-Yuan
authors.initials: ZY
authors.lastname: Ye
authors.forename: Hou-Quan
authors.initials: HQ
authors.lastname: Tao
authors.forename: Yuan-Yu
authors.initials: YY
authors.lastname: Wang
authors.forename: Zhong-Sheng
authors.initials: ZS
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D015815:Cell Adhesion Molecules