[Cytokine-mediated apoptosis of granulocytes eosinophilicus in eosinophilia].
The influence of recombinant forms of cytokincs (IL-5, IL-3 and eotaxin) on programmed destruction of eosinophils obtained from patients with diseases associated with high eosinophilia of blood (malignant diseases of system of blood, opisthorchosis) was studied in vitro. It was shown that all examined categories of patients irrespective of their nosology demonstrated a low level of spontaneous apoptosis of eosinophils. Cultivation of cosinophils isolated from peripheral blood of the patients with invasion O. felineus in vitro with r-IL-5, r-IL-3 and r-eotaxin decreased the number of eosinophilic cells undergoing apoptosis in comparison with spontaneous one. At the same time, incubation of eosinophils obtained from the patients with malignant diseases of system of blood, associated with cosinophilic syndrome, with r-IL-5, r-IL-3 and r-eotaxin allowed to ascertain the absence of sensitivity of eosinophilic cells to the antiapoptotic effect of these cytocines.
Litvinova
L S
LS
Riazantseva
N V
NV
Novitskiĭ
V V
VV
Grigor'eva
E S
ES
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology*; D004802:Eosinophilia / Q000150:complications / Q000276:immunology*; D004804:Eosinophils / Q000187:drug effects / Q000473:pathology*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000150:complications; D011994:Recombinant Proteins / Q000494:pharmacology
D016207:Cytokines; D011994:Recombinant Proteins