Asymmetric direct aldol reactions of pyruvic derivatives.
Simple chiral primary-tertiary diamine-Brønsted acid conjugates such as 1e can effectively catalyze the direct aldol reactions of pyruvic derivatives with excellent syn diastereoselectivities and enantioselectivities, thus functionally mimicking the pyruvate-dependent type I aldolases.
Luo
Sanzhong
S
Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry and Graduate School, Chinese Academy of Sciences, Beijing, China. luosz@iccas.ac.cn
Xu
Hui
H
Chen
Liujuan
L
Cheng
Jin-Pei
JP
D000446:Aldehyde-Lyases / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D019289:Pyruvic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D003959:Diamines; D019289:Pyruvic Acid; C116609:3-hydroxybutanal; D000446:Aldehyde-Lyases