[Idiopathic hyperuricemia with overproduction of uric acid].
Idiopathic hyperuricemia is generally defined as hyperuricemia caused by unknown origin. Idiopathic hyperuricemia is categorized as overproducing or underexcretion of uric acid. Overproduced uric acid is caused by increased biosynthesis of purine bodies, hypermetabolization of purine bodies, or increased intake of dietary purine bodies. Idiopathic hyperuricemia with overproducing uric acid can be diagnosed by amount of excreted uric acid in the urine. Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles. Some anti-hypertensive drugs including alpha1 blocker, ACE inhibitor, alphabeta blocker, or long-acting Ca blocker attenuated the myogenic hyperuricemia. Thus, these drugs may be helpful in the management of hypertension with hyperuricemia.
Mizuta
Einosuke
E
Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine.
Igawa
Osamu
O
Hisatome
Ichiro
I
D000959:Antihypertensive Agents / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D033461:Hyperuricemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D019271:Hypoxanthine / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D011687:Purines / Q000096:biosynthesis / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*
D000959:Antihypertensive Agents; D011687:Purines; D014527:Uric Acid; D019271:Hypoxanthine; C030985:purine