title: Progesterone receptor (PROGINS) polymorphism and the risk of ovarian cancer.
abstract: The present case-control study evaluates the role of the progesterone receptor (PR) polymorphism known as PROGINS as a risk factor for ovarian cancer development and investigates the association between these genetic variants and clinical/pathologic variables of ovarian cancer. PROGINS polymorphism was examined, by polymerase chain reaction, in a total of 80 patients with ovarian cancer and 282 control subjects. The frequencies of PROGINS polymorphism T1/T1, T1/T2, and T2/T2 were 71.3, 15.0 and 13.8% in ovarian cancer patients and 78.37, 21.63 and 0% in controls, respectively. The chi(2)-test showed a higher incidence of the T2/T2 genotype (P=0.001) in the ovarian cancer group. In addition, women carrying a mutated allele (T2) showed approximately 2.2 times higher risk of ovarian cancer development as compared to women who have a variant allele (odds ratio (OR)=2.2; 95% CI=1.80-3.54). Regarding the clinical and pathologic findings observed within the cancer group, there was a significant correlation between PROGINS polymorphism and patients with a familial history (chi(2)=6.776; P=0.009; Fischer exact test, P=0.01). In this regard, patients with familial antecedents have a 4.7 times higher likelihood to have at least one risk allele (T2) as compared with patients without familial antecedents (OR=4.69; 95% CI=1.38-15.87). No correlations were observed among the other variables. These data suggest that the PROGINS polymorphism T2/T2 genotype might be associated with an increased risk of ovarian cancer.
authors.affiliation: Molecular Gynecology Laboratory, Department of Gynecology, Federal University of São Paulo (UNIFESP-EPM), Brazil. dani.gineco@epm.br
authors.forename: Daniela B
authors.initials: DB
authors.lastname: Leite
authors.forename: Michele G
authors.initials: MG
authors.lastname: Junqueira
authors.forename: Cristina V
authors.initials: CV
authors.lastname: de Carvalho
authors.forename: Ana M
authors.initials: AM
authors.lastname: Massad-Costa
authors.forename: Wagner J
authors.initials: WJ
authors.lastname: Gonçalves
authors.forename: Sergio M
authors.initials: SM
authors.lastname: Nicolau
authors.forename: Luiz A F
authors.initials: LA
authors.lastname: Lopes
authors.forename: Edmundo C
authors.initials: EC
authors.lastname: Baracat
authors.forename: Ismael D C G
authors.initials: ID
authors.lastname: da Silva
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D011980:Receptors, Progesterone / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011980:Receptors, Progesterone