title: RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres.
abstract: In vertebrate cells, the small ubiquitin-like modifier SUMO plays a poorly defined role in targeting DNA topoisomerase II (TopoII) to centromeres (CENs) during mitosis, presumably to facilitate the untangling of sister chromatids as cells transition into anaphase. A new study by Dawlaty in the April 4 issue of Cell identifies the nucleoporin RanBP2 as a novel tumor suppressor that acts as a SUMO ligase for TopoII. Analysis of this interaction reveals TopoII recruitment to CENs is likely to play an important role in preventing chromosome segregation errors that lead to cancer.
authors.affiliation: Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Navarro
authors.forename: Jeff
authors.initials: J
authors.lastname: Bachant
mesh_terms: D000818:Animals; D002503:Centromere / Q000378:metabolism*; D002869:Chromosome Aberrations; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D051379:Mice; D018832:Molecular Chaperones / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D011485:Protein Binding; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D014981:Xenopus
chemical_list: D018832:Molecular Chaperones; D028861:Nuclear Pore Complex Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D025521:Tumor Suppressor Proteins; C094493:ran-binding protein 2; D004250:DNA Topoisomerases, Type II