title: An assessment of the accuracy of renal blood flow estimation by Doppler ultrasound.
abstract: BACKGROUND
  Knowledge of renal blood flow is considered important in the management of critically ill patients with acute renal failure. Renal Doppler ultrasound has been used to estimate renal blood flow. Its accuracy, however, has not been formally assessed.
  
  
  METHODS
  Prospective blinded animal study.
  
  
  METHODS
  University physiology laboratory.
  
  
  METHODS
  Seven merino cross-ewes.
  
  
  METHODS
  We chronically implanted transit-time flow probes around the left renal artery and performed Doppler ultrasound measurements of RBF. We simultaneously recorded RBF values obtained with implanted flow probes and Doppler ultrasound during (a) observation, (b) dobutamine and (c) nitroprusside infusion in random order.
  
  
  RESULTS
  In a total of 202 paired measurements, Doppler ultrasound measured peak systolic velocity (PSV) correlated very weakly with implanted flow probe measurements of RBF (r (2) = 0.015), as did end-diastolic velocity (EDV; r (2) = 0.086) and mean velocity (MV_vel; r (2) = 0.04). We also found similar weak correlations with other Doppler-ultrasound-derived indices. All comparisons showed bias and wide limits of agreement.
  
  
  CONCLUSIONS
  Doppler-ultrasound-derived estimates of RBF show little correlation with transit-time flow probe measurements, display significant bias and wide limits of agreement and have low accuracy for clinically significant changes in RBF in large animals.
authors.affiliation: Department of Intensive Care, Austin Hospital, 3084, Heidelberg, VIC, Australia.
authors.forename: Li
authors.initials: L
authors.lastname: Wan
authors.forename: Natalie
authors.initials: N
authors.lastname: Yang
authors.forename: Chee-Yan
authors.initials: CY
authors.lastname: Hiew
authors.forename: Anthony
authors.initials: A
authors.lastname: Schelleman
authors.forename: Lynne
authors.initials: L
authors.lastname: Johnson
authors.forename: Clive
authors.initials: C
authors.lastname: May
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001783:Blood Flow Velocity; D004280:Dobutamine / Q000494:pharmacology*; D005260:Female; D009599:Nitroprusside / Q000494:pharmacology*; D012372:ROC Curve; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012079:Renal Circulation / Q000187:drug effects*; D015203:Reproducibility of Results; D012756:Sheep; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000318:Adrenergic beta-Agonists; D014665:Vasodilator Agents; D009599:Nitroprusside; D004280:Dobutamine