Specificity of the mineralocorticoid receptor: crucial role of 11beta-hydroxysteroid dehydrogenase.
Research on the enzyme 11beta-hydroxysteroid dehydrogenase, initially performed on congenital deficiency of the enzyme, and later work on deficiency of the enzyme after licorice and carbenoxolone administration, led to the hypothesis that 11beta-hydroxysteroid dehydrogenase conferred specificity on the mineralocorticoid receptor.
Steward
P M
PM
Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK.
Edwards
C R
CR