The roles of oxidized low-density lipoprotein and interleukin-6 levels in acute atherothrombotic and lacunar ischemic stroke.
The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated. The study consisted of 28 patients with acute ischemic stroke and 23 control subjects. Patients were subdivided into large-vessel (n = 12) and small-vessel (n =16) disease stroke groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The means of oxidized low-density lipoprotein and interleukin-6 levels of patients with acute ischemic stroke were higher than controls (P < .01, P < .05). Mean oxidized low-density lipoprotein level was higher in the large-vessel disease group than in the small-vessel disease group (P < .01). The mean of inteleukin-6 levels was higher in the small-vessel disease group (P < .01). The results of the present study showed that oxidative stress promotes large-vessel disease rather than small-vessel disease stroke, and inflammation may play important an role in the development of small-vessel disease stroke.
Guldiken
Baburhan
B
Department of Neurology, Social Security Hospital, Trakya University Medical Faculty, Edirne, Turkey.
Guldiken
Sibel
S
Turgut
Burhan
B
Turgut
Nilda
N
Demir
Muzaffer
M
Celik
Yahya
Y
Arikan
Ender
E
Tugrul
Armagan
A
D000368:Aged; D001794:Blood Pressure; D002545:Brain Ischemia / Q000150:complications; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D002537:Intracranial Arteriosclerosis / Q000150:complications; D020767:Intracranial Thrombosis / Q000150:complications; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000209:etiology; D013599:Systole
D015850:Interleukin-6; D008077:Lipoproteins, LDL; D002784:Cholesterol