title: Clinicopathological features of lipomas with gene fusions involving HMGA2.
abstract: BACKGROUND
  Despite accumulating knowledge of chimeric genes derived from fusion of the HMGA2 gene with multiple partners in lipomas, the different clinicopathological features of lipomas depending on different gene aberrations have not been well documented. The purpose of this study was to examine the clinical significance of the expression of fusion genes in lipomas.
  
  
  METHODS
  The expressions of three previously reported gene fusion transcripts, including HMGA2/LPP, HMGA2/RDC1 and HMGA2/NFIB, were analyzed in 102 tumors from patients with lipomas.
  
  
  RESULTS
  There were 23 cases (22.5%) expressing HMGA2/LPP, 2 cases (1.9%) expressing HMGA2/RDC1 and no cases of HMGA2/NFIB expression (0%). There were no significant intergroup differences in age, gender, body mass index, tumor size or location. The magnetic resonance images and pathological features were also not different in regard to the status of fusion gene expression.
  
  
  CONCLUSIONS
  There were no significant differences of clinicopathological features in patients with lipoma with or without these fusion gene transcripts.
authors.affiliation: Department of Orthopaedic Surgery, Niigata Cancer Center Hospital, Niigata, Japan. hatanoh@niigata-cc.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hatano
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Morita
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hotta
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Segawa
authors.forename: Toru
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takenouchi
authors.forename: Toyoji
authors.initials: T
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D050939:Gene Fusion; D024003:HMGA Proteins / Q000235:genetics; D025743:HMGA2 Protein / Q000235:genetics*; D006801:Humans; D008067:Lipoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051839:NFI Transcription Factors / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D054387:Receptors, CXCR / Q000235:genetics
chemical_list: C501896:ACKR3 protein, human; D024003:HMGA Proteins; D025743:HMGA2 Protein; C502535:HMGA2-LPP fusion protein, human; D051839:NFI Transcription Factors; C110754:NFIB protein, human; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D054387:Receptors, CXCR