title: [Treatment of fatty liver disease].
abstract: Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of metabolic syndrome. The clinicopathologic spectrum ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). Simple steatosis has a relatively benign clinical course, but NASH can progress to cirrhosis and hepatocellular carcinoma. As yet there is no convincingly effective treatment for NAFLD and the best option for these patients might be a multimodal treatment plan targeting obesity, insulin resistance, diabetes mellitus, hyperlipidemia and hypertension.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Cobo Martín
authors.forename: Pedro
authors.initials: P
authors.lastname: Fernández Gil
authors.forename: Javier
authors.initials: J
authors.lastname: Crespo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D003131:Combined Modality Therapy; D015897:Comorbidity; D000075202:Contraindications; D003927:Diet, Diabetic; D004038:Diet, Reducing; D018450:Disease Progression; D000431:Ethanol; D005234:Fatty Liver / Q000178:diet therapy / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D008019:Life Style; D016031:Liver Transplantation; D024821:Metabolic Syndrome / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy; D051379:Mice; D008820:Mice, Obese; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D018962:Phlebotomy
chemical_list: D000975:Antioxidants; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D000431:Ethanol