title: Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.
abstract: BACKGROUND
  We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina.
  
  
  METHODS
  All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina.
  
  
  RESULTS
  All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P < .05).
  
  
  CONCLUSIONS
  Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis.
authors.affiliation: 1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece. aziakas@med.auth.gr
authors.forename: Antonios
authors.initials: A
authors.lastname: Ziakas
authors.forename: Stavros
authors.initials: S
authors.lastname: Gavrilidis
authors.forename: Efthimia
authors.initials: E
authors.lastname: Souliou
authors.forename: George
authors.initials: G
authors.lastname: Giannoglou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Stiliadis
authors.forename: Haralambos
authors.initials: H
authors.lastname: Karvounis
authors.forename: George
authors.initials: G
authors.lastname: Efthimiadis
authors.forename: Sotirios
authors.initials: S
authors.lastname: Mochlas
authors.forename: M Arvanitidou
authors.initials: MA
authors.lastname: Vayona
authors.forename: Apostolos
authors.initials: A
authors.lastname: Hatzitolios
authors.forename: Christos
authors.initials: C
authors.lastname: Savopoulos
authors.forename: Ifigenia
authors.initials: I
authors.lastname: Pidonia
authors.forename: George
authors.initials: G
authors.lastname: Parharidis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D002570:Ceruloplasmin / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors; D020107:Troponin T / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D020107:Troponin T; D005340:Fibrinogen; D002097:C-Reactive Protein; D002570:Ceruloplasmin