New perspectives in polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is, perhaps, the most common endocrinopathy affecting premenopausal women. Of such women, 5%-10% have the classic endocrine syndrome of hyperandrogenism and chronic anovulation. The syndrome not only has these long-appreciated reproductive morbidities, but it also has more recently recognized important metabolic consequences related to insulin resistance. This article reviews the current state of the field with respect to the pathogenesis of PCOS and the insulin resistance associated with it.
Diamanti-Kandarakis
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Department of Medicine, Medical School of Athens, Athens, Greece.
Dunaif
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