Insulin, growth factors, and cAMP: antagonism in the signal transduction pathways.
Depending on the cell type and the response, cAMP may either oppose or facilitate the actions of insulin and/or growth factors that signal via receptor tyrosine kinases. Recent findings indicate that the effects of the cyclic nucleotide are mediated in part by changes in the activities of important elements in the signal transduction pathways utilized by insulin and growth factors.
Graves
L M
LM
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA.
Lawrence
J C
JC