title: A tandem approach to isoquinolines from 2-azido-3-arylacrylates and alpha-diazocarbonyl compounds.
abstract: 2-Azido-3-arylacrylates react with alpha-diazocarbonyl compounds and triphenylphosphine to furnish isoquinolines in 60-92% yields. The tandem process involves a Wolff rearrangement, an aza-Wittig reaction, and an electrocyclic ring closure. The procedure is efficient, rapid, and general, and the substrates are readily available.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, China.
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Yang
authors.forename: Wang-Ge
authors.initials: WG
authors.lastname: Shou
authors.forename: Zheng-Bo
authors.initials: ZB
authors.lastname: Chen
authors.forename: Deng
authors.initials: D
authors.lastname: Hong
authors.forename: Yan-Guang
authors.initials: YG
authors.lastname: Wang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D003979:Diazonium Compounds / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D003979:Diazonium Compounds; D007546:Isoquinolines