Building better beta cells.
Type 1 diabetes represents an attractive target for human embryonic stem cell (hESC)-based cell replacement therapies. Recently, in Nature Biotechnology, Kroon et al. (2008) reported encouraging progress toward this goal with the development of functional islet-like structures in mice transplanted with hESC-derived pancreatic endoderm.
Stanley
Edouard G
EG
Monash Immunology and Stem Cell Laboratories, Level 3, Building 75, STRIP 1, West Ring Road, Monash University, Clayton, Victoria 3800, Australia. ed.stanley@med.monash.edu.au
Elefanty
Andrew G
AG
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation; D033581:Stem Cell Transplantation