Correlations of sialic acid with markers of inflammation, atherosclerosis and cardiovascular events in hemodialysis patients.
BACKGROUND
Serum total sialic acid (S-TSA) is associated with atherosclerotic process in general population. The aim of our study was to evaluate possible correlations of S-TSA with markers of inflammation and atherosclerosis in hemodialysis (HD) patients.


METHODS
We involved 53 asymptomatic, nondiabetic HD patients and 28 healthy controls. Atherosclerosis was evaluated by carotid ultrasonography, estimating intima media wall thickness and wall to lumen ratio bilaterally. To confirm our findings, we performed a 32-month cohort study, during which cardiovascular (CV) events were analyzed in relation to S-TSA concentration.


RESULTS
HD patients had higher S-TSA compared to controls (adjusted OR: 1.04, p = 0.026). In HD patients, S-TSA independently correlated with hs-CRP (p < 0.0001), lipoprotein(a) (p = 0.02), intima media wall thickness (p = 0.023) and wall to lumen ratio (p = 0.028). Increased S-TSA concentration was associated with more CV events (p = 0.03).


CONCLUSIONS
Serum TSA seems to correlate with inflammation, accelerated atherosclerosis and CV events in nondiabetic HD patients, but more studies need to confirm our findings.
Tseke
Paraskevi
P
Renal Unit, General Hospital Alexandra, University of Athens, Athens, Greece. tsekedaki@hotmail.com
Grapsa
Eirini
E
Stamatelopoulos
Kimon
K
Samouilidou
Elizabeth
E
Rammos
George
G
Papamichael
Christos
C
Zakopoulos
Nikolaos
N
D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000097:blood*; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D011446:Prospective Studies; D006435:Renal Dialysis; D020521:Stroke / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D016019:Survival Analysis
D019158:N-Acetylneuraminic Acid