Emerging role of microRNAs in disease pathogenesis and strategies for therapeutic modulation.
Micro (mi)RNAs are small, regulatory RNA molecules that are integral components of the genetic program in the majority of cells. They are thought to regulate up to one third of all human genes and have been linked to critical processes in disease pathogenesis. The diverse role of miRNAs in disease pathogenesis suggests that the modulation of miRNA function by utilizing techniques such as the use of antagomirs, locked nucleic acids, or miRNA sponges may produce novel therapeutic approaches. In this review, the current understanding of post-transcriptional gene regulation by miRNAs is discussed and insights into the function of miRNAs in tumorigenesis, immune responses, muscle function, organogenesis, and cell-lineage decisions are reviewed.
Mattes
Joerg
J
University of Newcastle, Faculty of Health and Hunter Medical Research Institute, School of Biomedical Sciences, Centre for Asthma and Respiratory Diseases, Newcastle, NSW 2300, Australia. joerg.mattes@newcastle.edu.au
Collison
Adam
A
Foster
Paul S
PS
D000818:Animals; D019070:Cell Lineage; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009132:Muscles / Q000502:physiology; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D038081:Organogenesis / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D014780:Viruses / Q000235:genetics
D035683:MicroRNAs