Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells.
We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.
Ohguchi
Kenji
K
Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kohguchi@giib.or.jp
Koike
Minako
M
Suwa
Yoshihide
Y
Koshimizu
Seiichi
S
Mizutani
Yuki
Y
Nozawa
Yoshinori
Y
Akao
Yukihiro
Y
D000434:Alcoholic Beverages / Q000032:analysis; D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D000521:alpha-MSH / Q000494:pharmacology
D005419:Flavonoids; D008543:Melanins; D010636:Phenols; D059808:Polyphenols; D000521:alpha-MSH; D014442:Monophenol Monooxygenase