title: Reciprocal regulation of bone and energy metabolism.
abstract: The finding that fat regulates bone metabolism was viewed as an indication that bone might regulate some aspects of energy metabolism in a feedback loop. The search that started nine years ago for a bone-derived hormone that regulates energy metabolism first took a convoluted path through the identification of a modifier gene. Once this hormone, osteocalcin, was identified, it became clear that bone exerts a profound and complex influence on glucose and fat metabolism. This review highlights the most important salient features of this novel regulation of energy metabolism.
authors.affiliation: Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Na Kyung
authors.initials: NK
authors.lastname: Lee
authors.forename: Gerard
authors.initials: G
authors.lastname: Karsenty
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D004734:Energy Metabolism; D005246:Feedback; D051379:Mice; D008817:Mice, Mutant Strains; D010006:Osteoblasts / Q000378:metabolism; D015675:Osteocalcin / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism
chemical_list: D015675:Osteocalcin