title: Oxidative amination of cuprated pyrimidine and purine derivatives.
abstract: Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.
authors.affiliation: Department Chemie and Biochemie, Ludwig-Maximilians-Universität, München, Germany.
authors.forename: Nadège
authors.initials: N
authors.lastname: Boudet
authors.forename: Srinivas Reddy
authors.initials: SR
authors.lastname: Dubbaka
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000586:Amination; D003300:Copper / Q000737:chemistry; D010084:Oxidation-Reduction; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013941:Thymine / Q000031:analogs & derivatives; D014498:Uracil / Q000031:analogs & derivatives
chemical_list: C471843:6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine; D011687:Purines; D011743:Pyrimidines; D014498:Uracil; D003300:Copper; D000225:Adenine; D013941:Thymine; C029892:cupric chloride