title: A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection.
abstract: BACKGROUND
  Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain.
  
  
  OBJECTIVE
  To compare the incidence and intensity of injection pain with 1% Propofol-LCT with 1% Propofol-LCT/MCT in female populations for minor surgery under total intravenous anesthesia (TIVA).
  
  
  METHODS
  One hundred and ten female patients were double-blind randomized into two groups. Group long-chain triglycerdes (L) received 1% propofol-LCT while group long-chain triglycerides/medium-chain triglycerides (L/M) received 1% propofol-LCT/MCT. All patients received no benzodiazepine premedication and fentanyl 1 microg/kg was given 3 minutes before propofol injection. The propofol 1 mg/kg was manually injected at 0.5 mL/sec. The verbal rating score (VRS 0-10) was recorded on pain of injection. VRS > 4 indicates a significant response to pain.
  
  
  RESULTS
  There was a significantly greater incidence and intensity of injection pain in group L compared with group L/M (p < 0.001 and p = 0.013 respectively).
  
  
  CONCLUSIONS
  Propofol-LCT/MCT is superior to propofol-LCT on reducing pain of injection.
authors.affiliation: Department of Anesthesiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Petchara
authors.initials: P
authors.lastname: Sundarathiti
authors.forename: Nuanjai
authors.initials: N
authors.lastname: Boonthom
authors.forename: Theerawat
authors.initials: T
authors.lastname: Chalacheewa
authors.forename: Porpimon
authors.initials: P
authors.lastname: Jommaroeng
authors.forename: Wanadee
authors.initials: W
authors.lastname: Rungsithiwan
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D015994:Incidence; D010146:Pain / Q000209:etiology* / Q000517:prevention & control; D010147:Pain Measurement; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D012307:Risk Factors; D014280:Triglycerides / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D014280:Triglycerides; D015742:Propofol