[Relationship between hyperuricemia and metabolic syndrome].
Metabolic syndrome is a cluster of cardiovascular risk factors such as hypertriglyceridemia, hypertension, insulin resistance, based on visceral fat accumulation. Hyperuricemia is also thought as a one of the complications of metabolic syndrome. Hyperinsulinemia caused by insulin resistance induces the low excretion type hyperuricemia. In contrast visceral fat accumulation itself causes the hypersynthetic type hyperuricemia through increased fatty acid influx into the liver. Recently hyperuricemia is suggested to play a causal role for the metabolic syndrome. Xanthine oxido-reductase, a key enzyme of uric acid metabolism was indicated as one of regulatory factors in adipocyte differentiation. These studies may shed a new light on the understanding of the relationship between hyperuricemia and metabolic syndrome.
Yamasaki
Tomoyuki
T
Osaka Medical Center for Cancer and Cardiovascular Diseases.
Tomita
Koji
K
D017667:Adipocytes / Q000166:cytology; D002318:Cardiovascular Diseases / Q000209:etiology; D002454:Cell Differentiation / Q000235:genetics; D006801:Humans; D033461:Hyperuricemia / Q000150:complications*; D024821:Metabolic Syndrome / Q000209:etiology*; D012306:Risk; D014527:Uric Acid / Q000378:metabolism; D014968:Xanthine Dehydrogenase / Q000502:physiology
D014527:Uric Acid; D014968:Xanthine Dehydrogenase