The effect of combination therapy with albendazole and praziquantel on hydatid cyst treatment.
The standard therapy of hydatid cyst is surgery but, in nonoperable patients and multiple organ involvement, medical therapy may be more useful. The efficacy of drugs especially in short-term treatment of hydatid cyst is unknown. This study was carried out to evaluate the effect of combination therapy with albendazole and praziquantel in the treatment of hydatid diseases. In a nonrandomized quasi-experimental study, nine patients with multiple hydatid cysts were treated with albendazole (400 mg/twice a day) and praziquantel (40 mg/kg per day) twice a week for 4 weeks. This regimen was repeated for three courses with a 2-week interval between each one. The average follow-up period after treatment was 18 months. Response to treatment was assessed through the observation of the symptoms and radiologic findings (computed axial tomography scan, sonography, X-ray). Symptoms disappeared in seven (77.8%) patients and improved partially in two (22.2%) patients. Radiological assessment showed significant improvement in five (55.6%) and partial improvement in four (44.4%) patients. Combination therapy with albendazole and praziquantel is effective in the treatment of hydatid cyst and can be used as an alternative to surgery in disseminated and nonoperable cases.
Jamshidi
Mahin
M
Department of Infectious Diseases, Hormozgan University of Medical Sciences, Hormozgan, P.O. Box 13185-1678, Tehran, Iran. swt_f@yahoo.com
Mohraz
Minou
M
Zangeneh
Mehrangiz
M
Jamshidi
Ali
A
D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004443:Echinococcosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*
D000871:Anthelmintics; D011223:Praziquantel; D015766:Albendazole