Von Recklinghausen's disease--elements of clinical practice.
Neurofibromatosis is a condition described for the first time by Von Recklingahausen in 1882. This disease is one of the most common genetic disorders and is characterized by multiple tumors of the central and peripheral nervous system, brown macules on the skin, bone deformities, and by vascular and visceral disorders. Despite extensive basic science research, the diagnosis is still based largely on clinical criteria, which often present gradually during childhood.
Burnei
G
G
Pediatric Orthopedic Clinic, Maria Sklodowska Curie Emergency Hospital for Children, Bucharest, Romania. mscburnei@yahoo.com
Vlad
C
C
Georgescu
Ileana
I
Gavriliu
S
S
Dan
Daniela
D
Vlad
Ana Maria
AM
D006801:Humans; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy