Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds.
A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity.
Barlow
James W
JW
Department of Pharmacognosy, School of Pharmacy, University of Dublin, Trinity College, Dublin 2, Ireland.
Walsh
John J
JJ
D000577:Amides / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016718:Arachidonic Acid; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C538765:4-amino-3,4-dihydro-2H-naphthalen-1-one; D000577:Amides; D000588:Amines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009281:Naphthalenes; D016718:Arachidonic Acid