Kinetic resolution of donor-functionalised tertiary alcohols by Cu-H-catalysed stereoselective silylation using a strained silicon-stereogenic silane.
A series of propargylic tertiary alcohols decorated with an sp2-hybridised nitrogen donor were kinetically resolved by reagent-controlled dehydrogenative Si-O coupling with a strained, highly reactive silicon-stereogenic cyclic silane.
Karatas
Betül
B
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstrasse 40, D-48149, Münster, Germany.
Rendler
Sebastian
S
Fröhlich
Roland
R
Oestreich
Martin
M
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007700:Kinetics; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry*; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D012821:Silanes; D003300:Copper; D009584:Nitrogen; D012825:Silicon