title: In situ ophthalmic gel of ciprofloxacin hydrochloride for once a day sustained delivery.
abstract: This article focuses on preparation and evaluation of a once a day ophthalmic delivery system for ciprofloxacin hydrochloride based on the concept of pH-triggered in situ gelation. The in situ gelling system involves the use of polyacrylic acid (Carbopol 980NF) as a phase transition polymer, hydroxypropyl methylcellulose (Methocel K100LV) as a release retardant, and ion exchange resin as a complexing agent. Ciprofloxacin hydrochloride was complexed with ion exchange resin to avoid incompatibility between drug and polyacrylic acid. The developed formulation was stable, and nonirritant to rabbit eyes and in vitro drug release was found to be around 98% over a period of 24 hours.
authors.affiliation: Pharmaceutical Sciences and Technology Division, Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai, India.
authors.forename: Satishkumar P
authors.initials: SP
authors.lastname: Jain
authors.forename: Sejal P
authors.initials: SP
authors.lastname: Shah
authors.forename: Namita S
authors.initials: NS
authors.lastname: Rajadhyaksha
authors.forename: Pirthi Pal
authors.initials: PP
authors.lastname: Singh P S
authors.forename: Purnima D
authors.initials: PD
authors.lastname: Amin
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000009:adverse effects; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D005123:Eye / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005782:Gels; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007475:Ion Exchange Resins / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D044367:Phase Transition; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D007475:Ion Exchange Resins; C479038:carbomer; D065347:Hypromellose Derivatives; D002939:Ciprofloxacin; D008747:Methylcellulose