title: Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor.
abstract: The purpose of this study is to investigate whether serum hyaluronan (HA) and serum-derived HA-associated proteins (SHAP)-HA complex predict cervical ripening and premature delivery. Sera were obtained from 64 women with normal pregnancies, 20 with full term delivery, and 13 with threatened premature labor. Concentrations of HA and SHAP-HA complex in serum were measured by sandwich ELISA. Serum concentrations of HA and SHAP-HA complex did not differ within first, second, and third trimester groups. The serum SHAP-HA complex was elevated in the full term labor group more than in the third trimester group; however, the concentrations of serum HA did not differ between both groups. The HA and SHAP-HA complex levels in sera were higher in the premature labor group than in the second trimester group. In the premature labor group, the SHAP-HA complex levels were higher in the cases with Bishop scores more than 4 points when compared with the cases with Bishop scores of 4 points or less. Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor.
authors.affiliation: Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine, Aichi, Japan.
authors.forename: Tameko
authors.initials: T
authors.lastname: Kishida
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Yabushita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wakatsuki
authors.forename: Lisheng
authors.initials: L
authors.lastname: Zhuo
authors.forename: Koji
authors.initials: K
authors.lastname: Kimata
mesh_terms: D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D020070:Cervical Ripening / Q000097:blood*; D002584:Cervix Uteri / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D046911:Macromolecular Substances / Q000032:analysis / Q000097:blood; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D011379:Prognosis; D015854:Up-Regulation / Q000502:physiology
chemical_list: D000510:Alpha-Globulins; D015415:Biomarkers; D046911:Macromolecular Substances; C011877:inter-alpha-inhibitor; D006820:Hyaluronic Acid