To evaluate the role of diclofenac sodium on renal parenchyma of young albino rats.
To study the effects of commonly used non steroidal anti-inflammatory drug diclofenac sodium on the kidneys of young albino rats after therapeutic dose. Early clinical and pharmacological studied of oral and parental forms of diclofenac sodium began shortly after the drug was discovered. However there is scanty information about the toxicities of normal dose of diclofenac in young albino rats. The present study is therefore designed to observe the gross and microscopic changes in kidney following administration of this drug in young albino rats. For this experimental study 16 albino rats were used; they were divided into two groups, each comprising of 8 animals. Group-1 received normal saline 10ml/kg body weight while group-2 received diclofenac sodium 2mg/kg body weight for two weeks. Micrometry was done on kidney tissue for proximal and distal tubular count, their diameter and the no of cells in these tubules. Highly significant changes were observed both in proximal and distal tubules of kidney. Even in therapeutic doses, Diclofenac Sodium causes damage to kidney tubules in young albino rats.
Yasmeen
Talat
T
Department of Anatomy, S.M.C., Karachi, Pakistan. yasmeentalat@yahoo.com
Yasmin
Farzana
F
Qureshi
Ghulam Sarwar
GS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D007686:Kidney Tubules, Distal / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D007687:Kidney Tubules, Proximal / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac