Relation of time of introduction of cow milk protein to an infant and risk of type-1 diabetes mellitus.
Several studies of infant feeding show a causal relationship between time of introduction of formula containing cow protein and risk of onset of type-1 diabetes mellitus. This paper cites the literature pro and con and discusses lipocalins which might play a role in the pathogensis. beta Lactoglobulin, a major lipocalin protein in bovine milk, is homologous to the human protein glycodelin (PP14), a T cell modulator. Anti-beta lactoglobulin cross-reacts with glycodelin. The newborn intestine does not have complete "closure" and can pass food antigens. Beta lactoglobulin could generate antibody to glycodelin undermining T cell regulation of beta cells.
Goldfarb
Marcia F
MF
Anatek-EP, Portland, ME 04104, USA. anatekep@maine.rr.com
D000293:Adolescent; D000818:Animals; D002417:Cattle; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D007782:Lactoglobulins / Q000235:genetics / Q000276:immunology; D008297:Male; D008892:Milk / Q000737:chemistry*; D016269:Milk Hypersensitivity / Q000276:immunology; D008894:Milk Proteins / Q000276:immunology*; D011257:Pregnancy Proteins / Q000235:genetics / Q000276:immunology; D012307:Risk Factors
D000071816:Glycodelin; D006023:Glycoproteins; D007782:Lactoglobulins; D008894:Milk Proteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins