Basophils are back!
In this issue of Immunity, Tsujimura et al. (2008) report that the release of platelet-activating factor by basophils stimulated with immunoglobulin G1 (IgG1)-antigen immune complexes contributes substantially to the expression of an IgG1-dependent alternative pathway of systemic anaphylaxis in mice.
Galli
Stephen J
SJ
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324, USA. sgalli@stanford.edu
Franco
Christopher B
CB
D000707:Anaphylaxis / Q000276:immunology / Q000401:mortality / Q000473:pathology; D000818:Animals; D001491:Basophils / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D051379:Mice; D010972:Platelet Activating Factor / Q000096:biosynthesis / Q000502:physiology
D007074:Immunoglobulin G; D010972:Platelet Activating Factor