title: Primary hepatic lymphoma of mucosa-associated lymphoid tissue type: a case report with cytogenetic study.
abstract: Primary hepatic lymphoma of mucosa-associated lymphoid tissue type is extremely rare. Only 38 cases have been reported to date. A case of a 59-year-old man with Helicobacter pylori-resistant gastric ulcers and Buerger disease who was followed up since 1999 is reported. A 2-cm hepatic nodule was incidentally found during partial gastrectomy and corresponded to mucosa-associated lymphoid tissue-type lymphoma without underlying liver disease. Molecular studies showed a clonal immunoglobulin heavy-chain gene rearrangement. Investigations for the mucosa-associated lymphoid tissue lymphoma-associated translocations t(11;18) and t(14;18), as well as the t(3;14)(q27;q32), were negative, whereas trisomy 3 and trisomy 18 were detected.
authors.affiliation: Département de Pathologie, Assistance Publique-Hôpitaux de Paris, Groupe Henri Mondor-Albert Chenevier, Créteil, France.
authors.forename: Wafa
authors.initials: W
authors.lastname: Koubaa Mahjoub
authors.forename: Marie-Therese
authors.initials: MT
authors.lastname: Chaumette-Planckaert
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Murga Penas
authors.forename: Judith
authors.initials: J
authors.lastname: Dierlamm
authors.forename: Karen
authors.initials: K
authors.lastname: Leroy
authors.forename: Marie-Helene
authors.initials: MH
authors.lastname: Delfau
authors.forename: Jerome
authors.initials: J
authors.lastname: Loriau
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Delchier
authors.forename: Elie-Serge
authors.initials: ES
authors.lastname: Zafrani
authors.forename: Christiane
authors.initials: C
authors.lastname: Copie-Bergman
mesh_terms: D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D018572:Disease-Free Survival; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014314:Trisomy