title: Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis.
abstract: COMT gene is a logical candidate gene for schizophrenia. Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls. In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt.
authors.affiliation: University Hospital Marques de Valdecilla, Department of Psychiatry, Santander (Cantabria), Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Mata
authors.forename: Rocio
authors.initials: R
authors.lastname: Perez-Iglesias
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Pelayo-Teran
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Rodríguez-Sanchez
authors.forename: Cesar
authors.initials: C
authors.lastname: Gonzalez-Blanch
authors.forename: Eugenio
authors.initials: E
authors.lastname: Carrasco-Marin
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Vazquez-Barquero
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008715:Methionine / Q000235:genetics; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012565:Schizophrenic Psychology; D014633:Valine / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine