title: [A case of liver metastasis of rectal cancer demonstrating complete response for three years to 5-FU/l-leucovorin].
abstract: We report a case in which 5-fluorouracil/l-leucovorin (5-FU/l-LV) combination therapy was remarkably effective for non-resectable advanced rectal cancer with multiple liver metastasis. A 68-year-old man complaining of severe abdominal distension and abdominal pain was diagnosed as having ileus due to rectal cancer. We established a diagnosis of non-resectable rectal cancer with multiple liver metastasis and therefore performed only rectal colostomy. Systemic chemotherapy with 5-FU/l-LV was scheduled for a total of 22 courses postoperatively. After the chemotherapeutic regimen, a CT scan and colonofiberscopy revealed the primary lesions had disappeared, and a histological examination of biopsy confirmed that the patient had achieved complete response (CR).
authors.affiliation: Department of Surgery, Senbon Hospital.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nobuhara
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kubo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sunami
authors.forename: Mizuyuki
authors.initials: M
authors.lastname: Kanemura
authors.forename: Taiho
authors.initials: T
authors.lastname: Yo
mesh_terms: D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood; D003113:Colonoscopy; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007150:Immunohistochemistry; D002955:Leucovorin / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D012004:Rectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D002272:Carcinoembryonic Antigen; D002955:Leucovorin; D005472:Fluorouracil