Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention.
The increasing availability of DNA-sequence information for multiple pathogenic and non-pathogenic variants of individual bacterial species has indicated that both DNA acquisition and genome reduction have important roles in genome evolution. Such genomic fluidity, which is found in human pathogens such as Escherichia coli, Helicobacter pylori and Mycobacterium tuberculosis, has important consequences for the clinical management of the diseases that are caused by these pathogens and for the development of diagnostics and new molecular epidemiological methods.
Ahmed
Niyaz
N
Pathogen Evolution Laboratory, Center for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500076, India.
Dobrindt
Ulrich
U
Hacker
Jörg
J
Hasnain
Seyed E
SE
D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D006801:Humans