When BAD is good for beta cells.
BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the regulation of glucose-stimulated insulin secretion and beta cell mass.
Philipson
Louis H
LH
Department of Medicine, University of Chicago, Chicago, IL 60637, USA. l-philipson@uchicago.edu
Roe
Michael W
MW
D017209:Apoptosis; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism*; D010766:Phosphorylation; D051025:bcl-Associated Death Protein / Q000737:chemistry* / Q000378:metabolism*
D007328:Insulin; D051025:bcl-Associated Death Protein; D005947:Glucose