title: Feline vaccine-associated fibrosarcoma induced by aluminium compound in two cats: short communication.
abstract: Two cases of feline vaccine-associated fibrosarcoma (FVAF) are reported. The excised tumours were both characterised as well circumscribed, subcutaneous, firm and white with central necrosis. Histopathologically, they consisted of well-differentiated and variably sized and shaped anaplastic cells, characterised by marked nuclear and cellular pleomorphism including giant cells. The mitotic activity was low. Aluminium was demonstrated in the central necrosis and giant cells. Neoplastic cells were positive for vimentin and negative for desmin and cytokeratin. The presence of feline sarcoma virus and feline immunodeficiency virus could not be detected by PCR in either case.
authors.affiliation: Department of Mammal Pathology, Central Agricultural Office, Veterinary Diagnostic Directorate, H-1149 Budapest, Tábornok u. 2, Hungary. z.deim@chello.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Deim
authors.forename: Nimród
authors.initials: N
authors.lastname: Palmai
authors.forename: Gábor
authors.initials: G
authors.lastname: Cserni
mesh_terms: D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000473:pathology; D002415:Cats; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008297:Male; D014612:Vaccines / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D014612:Vaccines; D000535:Aluminum