Longitudinal analysis of pulmonary function in adults with sickle cell disease.
Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.
Field
Joshua J
JJ
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. jfield@im.wustl.edu
Glassberg
Jeffrey
J
Gilmore
Annette
A
Howard
Joanna
J
Patankar
Sameer
S
Yan
Yan
Y
Davies
Sally C
SC
Debaun
Michael R
MR
Strunk
Robert C
RC
D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000502:physiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged