Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24](6-) polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate.
The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl)phosphate (BNPP) is promoted by the heptamolybdate anion [Mo7O24](6-) with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.
Cartuyvels
Els
E
Katholieke Universiteit Leuven, Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Absillis
Gregory
G
Parac-Vogt
Tatjana N
TN
D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry*
D008670:Metals; D010755:Organophosphates; D017973:Tungsten Compounds; D008982:Molybdenum; D004247:DNA; D010100:Oxygen