Rhabdomyolysis following accidental intra-arterial injection of local anesthetic.
Drug-induced myopathy, also named Nicolau syndrome, is a well-known phenomenon following intramuscular injection of certain agents, most commonly reported with penicillin or diclofenac. The mechanism responsible for the pathology is proposed to be incidental administration of the drug into the small arterioles. In this report, we present a Nicolau syndrome-like case that developed following accidental injection of a local anesthetic agent into the femoral artery during coronary angiography.
Selimoglu
Ozer
O
Goztepe Safak Hospital, Cardiovascular Surgery Clinic, Istanbul, Turkey.
Basaran
Murat
M
Ugurlucan
Murat
M
Ogus
Temucin Noyan
TN
D000059:Accidents; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects*; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D000925:Anticoagulants / Q000627:therapeutic use; D002196:Capillaries / Q000187:drug effects / Q000503:physiopathology; D017023:Coronary Angiography; D005260:Female; D005263:Femoral Artery; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use; D007269:Injections, Intra-Arterial; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D015607:Stents; D016896:Treatment Outcome; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000627:therapeutic use
D000779:Anesthetics, Local; D000925:Anticoagulants; D014665:Vasodilator Agents; D006493:Heparin; D016285:Iloprost