title: Diffuse minute clear cell proliferation in kidney: case report and review of literature.
abstract: To our knowledge, diffuse involvement of renal parenchyma by multiple minute foci of clear cell proliferations has not been previously reported. We report such a case, found incidentally, in an 86-year-old woman who had undergone right ureteronephrectomy for pyeloureteral urothelial carcinoma. Macroscopy of the kidney showed numerous yellow dot-like cortical nodules less than 0.3 cm. Histologic examination of the kidney and nodules revealed innumerable foci of minute clear cell proliferations in a background of chronic pyelonephritis. The benign or malignant nature of those clear cell microtumors was investigated by immunohistochemistry and fluorescent in situ hybridization analysis of chromosome 3p.
authors.affiliation: Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Marc.Pusztaszeri@chuv.ch
authors.forename: Marc
authors.initials: M
authors.lastname: Pusztaszeri
authors.forename: Luigi
authors.initials: L
authors.lastname: Tornillo
authors.forename: Hanifa
authors.initials: H
authors.lastname: Bouzourene
mesh_terms: D000369:Aged, 80 and over; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*