title: Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.
abstract: Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).
authors.affiliation: Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Rijken
authors.forename: Rose
authors.initials: R
authors.lastname: McGready
authors.forename: Machteld E
authors.initials: ME
authors.lastname: Boel
authors.forename: Marion
authors.initials: M
authors.lastname: Barends
authors.forename: Stephane
authors.initials: S
authors.lastname: Proux
authors.forename: Mupawjay
authors.initials: M
authors.lastname: Pimanpanarak
authors.forename: Pratap
authors.initials: P
authors.lastname: Singhasivanon
authors.forename: François
authors.initials: F
authors.lastname: Nosten
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000453:epidemiology; D005865:Gestational Age; D020073:Gravidity; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010298:Parity; D010963:Plasmodium falciparum / Q000302:isolation & purification; D010966:Plasmodium vivax / Q000302:isolation & purification; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000469:parasitology*; D011804:Quinolines / Q000627:therapeutic use*; D012189:Retrospective Studies; D013785:Thailand; D010879:Piperazines
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines