title: Web-based smoking-cessation programs: results of a randomized trial.
abstract: BACKGROUND
  Initial trials of web-based smoking-cessation programs have generally been promising. The active components of these programs, however, are not well understood. This study aimed to (1) identify active psychosocial and communication components of a web-based smoking-cessation intervention and (2) examine the impact of increasing the tailoring depth on smoking cessation.
  
  
  METHODS
  Randomized fractional factorial design.
  
  
  METHODS
  Two HMOs: Group Health in Washington State and Henry Ford Health System in Michigan.
  
  
  METHODS
  1866 smokers.
  
  
  METHODS
  A web-based smoking-cessation program plus nicotine patch. Five components of the intervention were randomized using a fractional factorial design: high- versus low-depth tailored success story, outcome expectation, and efficacy expectation messages; high- versus low-personalized source; and multiple versus single exposure to the intervention components.
  
  
  METHODS
  Primary outcome was 7 day point-prevalence abstinence at the 6-month follow-up.
  
  
  RESULTS
  Abstinence was most influenced by high-depth tailored success stories and a high-personalized message source. The cumulative assignment of the three tailoring depth factors also resulted in increasing the rates of 6-month cessation, demonstrating an effect of tailoring depth.
  
  
  CONCLUSIONS
  The study identified relevant components of smoking-cessation interventions that should be generalizable to other cessation interventions. The study also demonstrated the importance of higher-depth tailoring in smoking-cessation programs. Finally, the use of a novel fractional factorial design allowed efficient examination of the study aims. The rapidly changing interfaces, software, and capabilities of eHealth are likely to require such dynamic experimental approaches to intervention discovery.
authors.affiliation: Center for Health Communications Research, University of Michigan School of Public Health, Ann Arbor, MI 48109-0471, USA. strecher@umich.edu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Strecher
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: McClure
authors.forename: Gwen L
authors.initials: GL
authors.lastname: Alexander
authors.forename: Bibhas
authors.initials: B
authors.lastname: Chakraborty
authors.forename: Vijay N
authors.initials: VN
authors.lastname: Nair
authors.forename: Janine M
authors.initials: JM
authors.lastname: Konkel
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Greene
authors.forename: Linda M
authors.initials: LM
authors.lastname: Collins
authors.forename: Carola C
authors.initials: CC
authors.lastname: Carlier
authors.forename: Cheryl J
authors.initials: CJ
authors.lastname: Wiese
authors.forename: Roderick J
authors.initials: RJ
authors.lastname: Little
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Pomerleau
authors.forename: Ovide F
authors.initials: OF
authors.lastname: Pomerleau
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D020407:Internet; D008297:Male; D008824:Michigan; D008875:Middle Aged; D016540:Smoking Cessation / Q000379:methods*; D016896:Treatment Outcome