The role of DNA damage and repair in aging: new approaches to an old problem.
DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for healthy aging. Here I will briefly review these approaches in the context of the progress made in improving our understanding of the interrelationship between DNA damage, genome maintenance and mutations.
Vijg
Jan
J
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. jvijg@buckinstitute.org
D000375:Aging / Q000235:genetics*; D019588:Aging, Premature / Q000209:etiology / Q000235:genetics; D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009154:Mutation