Synthesis of some novel quinolines and pyrimido [4,5-b] quinolines bearing A sulfonamide moiety as potential anticancer and radioprotective agents.
Some novel 4-(quinolin-1-yl)-benzenesulfonamide and 4-(pyrimido[4,5-b]quinolin-10-yl)-benzenesulfonamide derivatives have been synthesized. All the newly synthesized target compounds were subjected to in vitro cytotoxic screening to be evaluated for their anticancer activity against Ehrlich ascites carcinoma cells. Among these new compounds, compounds 9a, 11, 12b, 18 and, in particular, 19 showed promising in vitro cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug. Moreover, compound 8 exhibited in vivo radioprotective activity against gamma-irradiation in mice.
Ghorab
Mostafa M
MM
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt. mmsghorab@yahoo.com
Ragab
Fatma A
FA
Noaman
Eman
E
Heiba
Helmy I
HI
El-Hossary
Ebaa M
EM
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood; D006801:Humans; D007202:Indicators and Reagents; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D008054:Lipid Peroxides; D011744:Pyrimidinones; D015363:Quinolones; D011837:Radiation-Protective Agents; D013449:Sulfonamides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione