title: Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.
abstract: Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9microM while azumamide A (1) showed only weak inhibition at 19microM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.
authors.affiliation: Department of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. ayocha@waseda.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Genta
authors.initials: G
authors.lastname: Narazaki
authors.forename: Takuhiro
authors.initials: T
authors.lastname: Hoshino
authors.forename: Satoko
authors.initials: S
authors.lastname: Maeda
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maejima
authors.forename: Jun K
authors.initials: JK
authors.lastname: Yamashita
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D051379:Mice; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D010456:Peptides, Cyclic / Q000494:pharmacology*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology; D011161:Porifera / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D010456:Peptides, Cyclic; C516229:azumanide E