Soraphinol C, a new free-radical scavenger from Sorangium cellulosum.
A new compound named soraphinol C (1) was isolated from myxobacteria Sorangium cellulosum KM1001 a soil isolate, together with a structurally related known compound, 4-hydroxysattabacin (2). These compounds were isolated by silica gel column chromatography and recycling preparative HPLC, consecutively. The structures of the compounds were determined on the basis of combined spectroscopic analyses. Compounds 1 and 2 exhibited antioxidant activity as a radical scavenger in the experiment using a hydrophilic free-radical initiator, 2,2'-azobis(2-amidinopropane)dihydrochloride with ORAC values of 0.956 and 0.617, respectively.
Li
Xuemei
X
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
Yu
Tae-Kyung
TK
Kwak
Jong Hwan
JH
Son
Byoung-Yil
BY
Seo
Youngwan
Y
Zee
Ok-Pyo
OP
Ahn
Jong-Woong
JW
D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006588:Hexanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009231:Myxococcales / Q000378:metabolism*; D012988:Soil Microbiology
D016166:Free Radical Scavengers; D006588:Hexanones; C529903:soraphinol C; C096625:hydroxysattabacin