title: Primary cardiac osteosarcoma with recurrent episodes and unusual patterns of metastatic spread.
abstract: Primary osteosarcoma of the heart is an extremely rare entity. In this report, we describe a case of primary osteosarcoma of the heart that recurred and metastasized. The patient is a 50-year-old woman who presented with an abrupt onset of dyspnea, dizziness, and palpitations. Echocardiography results showed a left atrial tumor that was resected and had histological features of high-grade osteosarcoma. The patient was treated with adjuvant chemotherapy. The tumor recurred in the same location 4 years later and was resected. Three years later, the patient presented with a 4-cm polypoid mass in the stomach that was consistent with metastatic osteosarcoma. One year later, the patient presented with recurrent high-grade sarcoma in the soft tissue of the left chest wall. We herein present the spectrum of histological findings and molecular genotyping data.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA 15232, USA. parwaniav@upmc.edu
authors.forename: Anil V
authors.initials: AV
authors.lastname: Parwani
authors.forename: Nicole
authors.initials: N
authors.lastname: Esposito
authors.forename: Uma N M
authors.initials: UN
authors.lastname: Rao
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D005260:Female; D005838:Genotype; D006338:Heart Neoplasms / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D042282:Microdissection; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012516:Osteosarcoma / Q000235:genetics / Q000503:physiopathology / Q000556:secondary*; D016133:Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics / Q000556:secondary; D035441:Thoracic Wall / Q000473:pathology