title: Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis.
abstract: This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >or=0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.
authors.affiliation: Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Kelly Aparecida
authors.initials: KA
authors.lastname: Kanunfre
authors.forename: Olavo Henrique Munhoz
authors.initials: OH
authors.lastname: Leite
authors.forename: Max Igor
authors.initials: MI
authors.lastname: Lopes
authors.forename: Marcelo
authors.initials: M
authors.lastname: Litvoc
authors.forename: Antonio Walter
authors.initials: AW
authors.lastname: Ferreira
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D001938:Brazil; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C117940:CFP-10 protein, Mycobacterium tuberculosis; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D007371:Interferon-gamma