Deep brain stimulation in Tourette's Syndrome.
Tourette's Syndrome (TS) is a neuropsychiatric disorder characterized by motor and vocal tics, often associated with behavioral disorders. Symptoms often disappear before or during adulthood. The pathophysiology of TS is still a matter of considerable debate. Current knowledge of cortico-basal ganglia-thalamocortical circuits provide explanations for the beneficial effects of deep brain stimulation (DBS) on tics. When conservative treatment fails in patients with severe TS, DBS may be a therapeutic option. In 1999, thalamic DBS was introduced for intractable TS. Since then, multiple targets have been used in a small number of patients, including the globus pallidus pars interna and the nucleus accumbens. Inclusion and exclusion criteria have been formulated to identify good candidates for DBS.
Ackermans
Linda
L
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands.
Temel
Yasin
Y
Visser-Vandewalle
Veerle
V
D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D005879:Tourette Syndrome / Q000628:therapy*