Cyclic GMP and the second messenger hypothesis.
A plasma membrane form of guanylate cyclase appears to contain a single transmembrane domain that divides the protein into a highly conserved intracellular domain and a variable extracellular domain. Various extracellular peptides can bind directly to guanylate cyclase to increase the production of the second messenger, cyclic GMP.
Garbers
D L
DL
David L. Garbers is at the Howard Hughes Medical Institute, Departments of Pharmacology and Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, TN 37232, USA.