title: Role of environmental and genetic factor interaction in age-related disease development: the gastric cancer paradigm.
abstract: The association of Helicobacter pylori (Hp) infection with gastric cancer is well known and might be considered a paradigmatic example of the role that interaction among environmental factors and individual background might play in inducing age-associated disease. To evaluate the role of interaction of Hp infection with genetic background, gastric cancer and chronic gastritis patients as well as random selected controls were typed for five inflammation-related polymorphisms of IL-1 and IL-10 cytokine genes. No association among IL-10 or IL-1 variants with an increased risk of gastric cancer was found, whereas an Hp-independent association of IL-1beta -511T positive genotypes to an increased risk of chronic gastritis was found (Hp-/511T+ OR 1.89, 95% CI: 1.01-3.54; Hp+/-511T+ OR 1.83, 95% CI: 1.05-3.19). Stratification of gastric cancer group according to Hp infection does not allow finding a statistically significant association of Hp+ to the higher histological grading (G3) of gastric cancer (OR 1.54, 95% CI: 0.46-5.11). Our findings seem to confirm that cytokine genetic variants might contribute to determining the background for inflammaging in which H. pylori infection might facilitate cancer development.
authors.affiliation: Department of Pathobiology and Biomedical Methodology, University of Palermo, Palermo, Italy.
authors.forename: Giusi Irma
authors.initials: GI
authors.lastname: Forte
authors.forename: Cinzia
authors.initials: C
authors.lastname: Calà
authors.forename: Letizia
authors.initials: L
authors.lastname: Scola
authors.forename: Antonino
authors.initials: A
authors.lastname: Crivello
authors.forename: Arianna
authors.initials: A
authors.lastname: Gullo
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Marasà
authors.forename: Antonio
authors.initials: A
authors.lastname: Giacalone
authors.forename: Celestino
authors.initials: C
authors.lastname: Bonura
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Anna
authors.initials: A
authors.lastname: Giammanco
mesh_terms: D000375:Aging / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D004194:Disease; D004777:Environment; D005260:Female; D005756:Gastritis / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D016207:Cytokines