Studies on the constituents from the fruits of Phaleria macrocarpa.
From the fruits of Phaleria macrocarpa, icariside C(3) (1), phalerin (2), and mangiferin (3) were isolated and their structures were identified on the basis of spectroscopic data. Icariside C(3) (1) showed a slow vasorelaxant activity against noradrenaline-induced contraction of isolated rat aorta. The structure of phalerin (2) was revised as 2,4',6-trihydroxy-4-methoxybenzophenone-2-O-beta-D-glucoside.
Oshimi
Shiori
S
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, 142-8501, Japan.
Zaima
Kazumasa
K
Matsuno
Yosuke
Y
Hirasawa
Yusuke
Y
Iizuka
Toru
T
Studiawan
Herra
H
Indrayanto
Gunawan
G
Zaini
Noor Cholies
NC
Morita
Hiroshi
H
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C529772:2,4',6-trihydroxy-4-methoxybenzophenone-2-O-glucoside; D001577:Benzophenones; D005960:Glucosides; D010936:Plant Extracts; D012717:Sesquiterpenes; D014665:Vasodilator Agents; D044004:Xanthones; C529773:icariside C3; C013592:mangiferin; D009638:Norepinephrine