title: Polymorphisms of the ICAM-1 gene are associated with biliary atresia.
abstract: Inflammation is an important feature of biliary atresia, and recent studies suggest that its occurs in a genetically susceptible host. The intercellular adhesion molecule-1 (ICAM-1) is of paramount importance for the initiation and propagation of various inflammatory conditions.
  
  
  OBJECTIVE
  To determine whether the Glu241Arg polymorphism in the ICAM-1 gene, which impairs inflammatory responses, is associated with biliary atresia.
  
  
  METHODS
  Between February 2002 and November 2004, 19 patients (mean age 1 +/- 0.4 years) diagnosed as biliary atresia were included in the study. Thirty-eight children with chronic liver disease and a group of unrelated healthy controls (n = 123) included in this study. After informed consent, blood was collected and genomic DNA was obtained. Genotyping was performed by amplification-refractory mutation system polymerase chain reaction (ARMSPCR). Associations were assessed by using Fischer's exact test.
  
  
  RESULTS
  ICAM G242R A allele frequency was significantly higher in the BA group than in both the CLD and healthy control groups (OR = 4.4, 95 CI% 1.3-15.1, P = 0.03 and OR = 4.8 CI% 1.5-15.6, P = 0.01, respectively). Univariate analysis showed that polymorphism of ICAM G241R polymorphism was significantly related to biliary atresia. There was not significant correlation between PELD score and ICAM-1 genotypes both in BA and CLD groups.
  
  
  CONCLUSIONS
  These findings provide evidence for the possible role of ICAM-1 241R polymorphism in BA pathogenesis.
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, 250. sok. No: 6 D: 1, Bornova, Izmir 35040, Turkey. arikan@med.ege.edu.tr
authors.forename: Cigdem
authors.initials: C
authors.lastname: Arikan
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: Murat
authors.initials: M
authors.lastname: Kilic
authors.forename: Gokhan
authors.initials: G
authors.lastname: Tumgor
authors.forename: Rasit V
authors.initials: RV
authors.lastname: Yagci
authors.forename: Sema
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D001656:Biliary Atresia / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D018709:Statistics, Nonparametric
chemical_list: D018799:Intercellular Adhesion Molecule-1