Isolation and structure determination of the cembranoid eunicin from a new genus of octocoral, Pseudoplexaura.
The known cembranoid diterpene eunicin (1) was isolated from a new genus of octocoral, Pseudoplexaura, collected in the Caribbean. The complete assignment of the 13C and 1H NMR spectra, including differentiation of pro-R and pro-S hydrogens and elucidation of all J values, was accomplished with the aid of TOCSY, HSQC, and HMBC data, and a consideration of three low-energy conformations using SYBYL.
Sponholtz
William R
WR
Department of Science, Cushing Academy, Ashburnham, MA 01430, USA.
Bianco
Michelle A
MA
Gribble
Gordon W
GW
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D005779:Immunodiffusion; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009904:Optical Rotation; D013211:Staphylococcus aureus / Q000187:drug effects
D000935:Antifungal Agents; D004224:Diterpenes; C082582:eunicin