Autoantibodies to myosin light chains in the blood as early marker of myocardial injury after aortocoronary bypass surgery.
Serum concentration of autoantibodies to myosin light chains was measured after resumption of the bloodflow recovery in patients who underwent hypothermic aortocoronary bypass surgery. The patients were divided into 3 groups according to postoperative hemodynamic parameters and degree of myocardial injury. The studies showed significant differences in the concentrations of autoantibodies to myosin light chains between the groups. High correlation was shown between the duration of aorta clamping and concentration of autoantibodies to myosin light chains. Some factors characterizing initial severity of the disease can modulate blood concentration of autoantibodies to myosin light chains.
Bledzhyants
D A
DA
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino. blejyants@rambler.ru
Muratov
R M
RM
Movsesyan
R R
RR
Podlubnaya
Z A
ZA
D000328:Adult; D001011:Aorta; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003250:Constriction; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000276:immunology*; D018994:Myosin Light Chains / Q000276:immunology*; D012307:Risk Factors; D013997:Time Factors
D001323:Autoantibodies; D015415:Biomarkers; D018994:Myosin Light Chains