[Lack of association between the APOE genotype and the response to statin treatment in patients with acute ischemic episodes].
OBJECTIVE
APOE genotype has been shown to have an influence on lipid concentrations. However, its relation with response to lipid-lowering treatment is not well established. The aim of our work was to analyze whether this genotype is associated with changes in the lipid profile in response to statins treatment.


METHODS
A total of 222 consecutive patients with acute ischemic episodes and subjected to treatment with statins were included in a retrospective study. The patients' lipid profile was determined at the first visit to the Lipids Unit and after one year on a statin regime. APOE genotypes were determined by PCR-RFLP, and separated in three groups: E2 (E2 carriers), E4 (E4 carriers) and E3 (E3/E3). E2/E4 patients were not included in the study.


RESULTS
Relative frequencies of alleles epsilon2, epsilon3 and epsilon4 were 10.5%, 70.9% and 18.6% respectively. Significant differences among groups (p = 0.039) were observed for c-LDL concentrations. E2 group had lower c-LDL than E3 group (p = 0.017) and E4 group (p = 0.01). No significant differences in c-LDL, c-HDL and c-HDL/CT were observed among the three groups with regard to variation after statin treatment.


CONCLUSIONS
APOE genotype does not significantly affect the lipid response in patients with acute ischemic episodes after statin treatment.
Sousa
Marinez Oliveira
MO
Laboratorio de Bioquímica Hormonal y Génica, Hospital Universitario de Bellvitge, Barcelona, Spain. marinez@farmacia.ufmg.br
Corbella
Emilio
E
Alía
Pedro
P
Cámara
Jordi
J
Castro
María José
MJ
Pintó
Xavier
X
Navarro
Miguel Angel
MA
D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
D001057:Apolipoproteins E; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors