title: Antidepressants: will new mechanisms of action improve poor outcomes?
abstract: Depression is one of the most common mental illnesses and has a high impact on individuals and society. Despite the numerous treatment approaches, poor response combined with the burden of residual symptoms negatively affects the overall outcome. Novel pharmacological approaches could help to address this issue.
authors.affiliation: Institute of Neuroscience, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne.
authors.forename: Lena
authors.initials: L
authors.lastname: Palaniyappan
authors.forename: R Hamish
authors.initials: RH
authors.lastname: McAllister-Williams
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors