title: Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats.
abstract: Anti-diabetic, anti-hyperlipidemic and spermatogenic effects were studies with methanolic extract of stem of Amaranthus spinosus Linn (Family: Amaranthaceae) in diabetic rats. In streptozotocin (STZ)-induced diabetic rats, it was observed that both the standard drug (Glibenclamide) and methanolic extract of Amaranthus spinosus Linn. significantly exhibited control of blood glucose level on a 15 day model. Further, the methanolic extract also showed significant anti-hyperlipidemic and spermatogenic effects in STZ-induced diabetic rats. The methanolic extract has also accelerated the process of spermatogenesis by increasing the sperm count and accessory sex organ weights. The present investigation of the plant established some pharmacological evidence to support the folklore claim that it is used as an anti-diabetic.
authors.affiliation: Vinayaka Mission's College of Pharmacy, Vinayaka Missions University, Kondappanaickan patty, Salem, 636 008, Tamil Nadu, India. sangar1970@yahoo.co.in
authors.forename: B
authors.initials: B
authors.lastname: Sangameswaran
authors.forename: B
authors.initials: B
authors.lastname: Jayakar
mesh_terms: D027721:Amaranthus; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007928:Lethal Dose 50; D008055:Lipids / Q000097:blood; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D009929:Organ Size; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems; D051381:Rats; D012997:Solvents / Q000737:chemistry; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D012997:Solvents; D005905:Glyburide; D000432:Methanol