title: [Palifermin in the preventive treatment of oral mucositis in autograft patients: data on efficacy and tolerance following marketing approval].
abstract: BACKGROUND
  Few data are available on the efficacy of and tolerance to palifermin in the preventive treatment of oral mucositis in autograft patients treated with conditioning protocols usually used in France.
  
  
  METHODS
  Our retrospective study bears on the first five candidates for autograft who benefited from prophylactic treatment with palifermin (60 microg/kg/day) between December 2005 and March 2006.
  
  
  RESULTS
  Despite the prophylactic treatment, 3 patients developed severe oral mucositis. Moreover, in 3 patients, palifermin was found to be responsible for the onset of severe toxidermia, which required, in 2 cases, interruption of the treatment.
  
  
  CONCLUSIONS
  These results need to be confirmed by a larger study that would also make it possible to evaluate the impact of palifermin on morbi-mortality in autograft patients in France, and to determine the safety profile of this drug.
authors.affiliation: Service Pharmacie, Hôpital du Bocage, CHU Dijon, Dijon, France. onteniente.sylvain@voila.fr
authors.forename: Sylvain
authors.initials: S
authors.lastname: Onteniente
authors.forename: Valérie
authors.initials: V
authors.lastname: Coullet
authors.forename: Mathilde
authors.initials: M
authors.lastname: Chemelle
authors.forename: Ingrid
authors.initials: I
authors.lastname: Lafont
authors.forename: Corinne
authors.initials: C
authors.lastname: Pernot
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Guignard
mesh_terms: D000368:Aged; D017690:Cell Transplantation; D003875:Drug Eruptions / Q000473:pathology; D005260:Female; D051523:Fibroblast Growth Factor 7 / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000628:therapy; D012189:Retrospective Studies; D013280:Stomatitis / Q000209:etiology* / Q000517:prevention & control*; D014182:Transplantation, Autologous
chemical_list: D051523:Fibroblast Growth Factor 7