title: Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a dog: case report.
abstract: A 12-year-old, intact female beagle exhibited symptoms of polyuria-polydipsia and hyperorexia for two months. Blood tests showed elevated asparate aminotransferase, alanine aminotransferase, alkaline phosphatase and creatine kinase levels, as well as marked hypokalemia. The results of adrenocorticotropic hormone stimulation test showed elevated cortisol, aldosterone and corticosterone concentrations. Abdominal ultrasonography confirmed a mass in the left adrenal gland. Masses were also seen in the liver and caudal vena cava. Diagnosis was a tumor of the adrenal cortex with metastases. Trilostane administration was initiated. The dog initially showed improved demeanor as a result of regulating hormone secretion. However, after 88 days, the dog weakened rapidly, before dying on the 117th day. Pathological findings confirmed a diagnosis of adrenocortical carcinoma.
authors.affiliation: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. hiko-t-ponko@hotmail.co.jp
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Machida
authors.forename: Eiji
authors.initials: E
authors.lastname: Uchida
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsuda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hirayama
authors.forename: Kengoro
authors.initials: K
authors.lastname: Yoshii
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Takiguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Taniyama
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging; D018268:Adrenocortical Carcinoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D013196:Dihydrotestosterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D014463:Ultrasonography
chemical_list: D013196:Dihydrotestosterone; D000450:Aldosterone; C009954:trilostane; D003345:Corticosterone; D006854:Hydrocortisone