title: Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates.
abstract: Osteonecrosis of the jaws (ONJ) is an important possible late adverse effect of bisphosphonates. Serum C-terminal cross-linking telopeptide of type I collagen (CTX) can determine bone turnover and can act as a biological marker of bone resorption. We studied this biological marker in 15 patients (Group 1) with bisphosphonate-induced ONJ comparing with a control group of 10 healthy people matched by age and gender. We found no statistically significant relationships in Group 1 either between the serum CTX and the number of areas of exposed bone nor with the size of the osteonecrotic area.
authors.affiliation: Service of Stomatology, University General Hospital, Valencia University, Spain. bagan@uv.es
authors.forename: Jose V
authors.initials: JV
authors.lastname: Bagan
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jiménez
authors.forename: Dolores
authors.initials: D
authors.lastname: Gómez
authors.forename: Rafael
authors.initials: R
authors.lastname: Sirera
authors.forename: Rafael
authors.initials: R
authors.lastname: Poveda
authors.forename: Crispian
authors.initials: C
authors.lastname: Scully
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001862:Bone Resorption / Q000097:blood / Q000139:chemically induced; D016022:Case-Control Studies; D024042:Collagen Type I / Q000097:blood*; D004164:Diphosphonates / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007571:Jaw Diseases / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000097:blood / Q000139:chemically induced*; D000077211:Zoledronic Acid
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid