title: Mucinous tubular and spindle cell carcinoma with aggressive histomorphology--a sarcomatoid variant.
abstract: Mucinous tubular and spindle cell carcinoma (MTSCC) is a recently described renal epithelial tumor. The bland cytomorphology of the spindled component and low-grade behavior help in its differentiation from sarcomatoid renal carcinoma. Sarcomatoid change has been reported in most histologic variants of renal cell carcinoma apart from MTSCC. Herein we report a case of an MTSCC in a 72-year-old female patient with high-grade spindled areas resembling fibrosarcomatous and undifferentiated pleomorphic sarcoma patterns with metaplastic bone. This index case also demonstrates a high proliferation index and extensive necrosis representing the first documented case of sarcomatoid change in MTSCC.
authors.affiliation: NHLS, Inkosi Albert Luthuli Central Hospital, Durban, South Africa. NischalanPil@ialch.co.za
authors.forename: Nischalan
authors.initials: N
authors.lastname: Pillay
authors.forename: Pratistadevi K
authors.initials: PK
authors.lastname: Ramdial
authors.forename: Kumarasen
authors.initials: K
authors.lastname: Cooper
authors.forename: David
authors.initials: D
authors.lastname: Batuule
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008938:Mitosis; D009336:Necrosis; D009392:Nephrectomy; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor