[The up-regulated expression of LAIR-1 in tumor patients PBMC].
OBJECTIVE
To investigate the expression of LAIR-1 in patients with tumors and the function of LAIR-1 in anticancer immunity.


METHODS
A sandwich ELISA was employed to detect the serum sLAIR-1 from tumor patients and healthy individuals. The expression of LAIR-1 in CD4+ T cells, CD8+ T cells, NK cells and B cells isolated from the peripheral blood of cancer patients was examined by fluorescence staining and flow cytometry.


RESULTS
The level of serum sLAIR-1 in tumor patients was higher than that in healthy individuals [4.6+/-3.2 microg/L vs 3.9+/-3.0 microg/L, P<0.05]. NK cells, CD4+ T cells and CD8+ T cells expressed the up-regulated LAIR-1. The ratio of CD4/CD8 in lung cancer patients decreased significantly while the percentage of B cells in cancer patients increased greatly compared with healthy individuals.


CONCLUSIONS
The expression of LAIR-1 is up-regulated in tumor patients, which may contribute to cancer immune escape.
Xue
Jiang-nan
JN
Department of Immunology, Binzhou Medical University, Yantai 264003, China. xuejinagnan@263.net
Wang
Chun-yan
CY
Zhang
Xiao-shu
XS
Cao
Qi-zhi
QZ
Su
Zhen-guo
ZG
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D011971:Receptors, Immunologic / Q000097:blood* / Q000378:metabolism*; D055815:Young Adult
D011971:Receptors, Immunologic; C108073:leukocyte-associated immunoglobulin-like receptor 1