title: [A prospective study on wound-healing hydrogel in treating chronic venous ulcer of lower extremities].
abstract: OBJECTIVE
  To study the outcome of wound-healing hydrogel in treating chronic venous ulcer of lower extremities so as to find a new therapy.
  
  
  METHODS
  From April 2007 to September 2007, 60 patients with chronic venous ulcer of lower extremities were randomly assigned to wound-healing hydrogel group (group A, 30 cases) and control group (normal saline, group B, 30 cases). In group A, there were 24 males and 6 females, aging (57.3 +/- 6.8) years; the disease course was (2.9 +/- 0.7) years; and the ulcer area was (3.4 +/- 0.6) cm2. In group B, there were 20 males and 10 females, aging (60.1 +/- 7.4) years; the disease course was (3.3 +/- 0.9) years; and the ulcer area was (3.1 +/- 0.4) cm2. There were no differences in age, area of ulcer and course of disease between two groups (P > 0.05). The area of ulcer was measured every week after the treatment, and the effect of treatment was evaluated after 15 days.
  
  
  RESULTS
  The ulcer area of 7 days and 14 days after treatment was (2.6 +/- 0.7) and (1.1 +/- 0.2) cm2 in group A, and (2.8 +/- 0.6) and (2.3 +/- 0.7) cm2 in group B, respectively; showing no statistically significant differences 7 days after treatment (P > 0.05), and showing statistically significant difference 14 days after treatment between two groups (P < 0.05). The average healing time was (12.0 +/- 1.7) days in group A, and (31.0 +/- 2.9) days in group B, respectively, showing statistically significant difference (P < 0.01). The results were excellent, good, fair and poor in 16, 9, 4 and 1 of group A, and were in 3, 9, 14 and 4 of group B, respectively; showing statistically significant difference (P < 0.01).
  
  
  CONCLUSIONS
  Wound-healing hydrogel is effective in treating chronic venous ulcer of lower extremities.
authors.affiliation: Departmen of General and Vascular Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Tan
authors.initials: T
authors.lastname: Zhang
authors.forename: Wenbin
authors.initials: W
authors.lastname: Wang
authors.forename: Qisheng
authors.initials: Q
authors.lastname: Gu
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D047070:Bandages, Hydrocolloid; D002908:Chronic Disease; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000627:therapeutic use*; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate