Regulatory T-cell immunity and its relevance to atherosclerosis.
Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Recent studies from several groups suggest that subtypes of T cells, called regulatory T cells, previously shown to maintain immunological tolerance, inhibit the development and progression of atherosclerosis. Here, we review the current knowledge on the regulatory T-cell response and the major cytokines involved in its modulation in the context of atherosclerosis.
Taleb
S
S
Centre de Recherche Cardiovasculaire Lariboisière, Inserm U689, Paris, France.
Tedgui
A
A
Mallat
Z
Z
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D050197:Atherosclerosis / Q000276:immunology* / Q000503:physiopathology; D016207:Cytokines / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology; D007113:Immunity, Innate; D016753:Interleukin-10 / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology
D015703:Antigens, CD; D016207:Cytokines; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D016212:Transforming Growth Factor beta; D016753:Interleukin-10