title: Neuron specific enolase tissue expression as a prognostic factor in advanced non small cell lung cancer.
abstract: OBJECTIVE
  To determine the frequency of neuron specific enolase (NSE) tissue expression and its possible influence on survival of patients treated for advanced non small cell lung cancer (NSCLC).
  
  
  METHODS
  We studied 158 patients with histological diagnosis of NSCLC (stage III/IV). Combined chemoradiotherapy was used in stage III disease (without pleural effusion), whereas chemotherapy only was used in stage III (with pleural effusion) as well as in stage IV disease. Immunohistochemical analysis of NSE expression was determined using antibodies to NSE (DAKO, Den). One- and 2-year overall survival were assessed.
  
  
  RESULTS
  45 (28.5%) patients had positive NSE expression. The most frequent NSE expression was seen in 6/9 (66.7%) patients with large cell carcinoma and in 23/50 (46%) with adenocarcinoma. One- and 2-year survival rates were 70% and 30% in the group of patients with positive NSE expression compared to 26% and 3% in the group with negative NSE expression (p=0.000). The median survival time was 16.4 vs. 11.4 months in the groups of patients with and without NSE expression, respectively (p < 0.001). One-and 2-year survival rate was higher in NSCLC patients with more than 50% of NSE positive cancer cells (p=0.0004 and 0.000, respectively).
  
  
  CONCLUSIONS
  A total of 28.5% of advanced NSCLC patients had positive NSE expression. Median 1- and 2-year survival time was significantly longer in patients with positive NSE expression.
authors.affiliation: Department of Pulmonology, Medical Faculty, University of Kragujevac, Serbia. drmarinapetrovic@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Petrovic
authors.forename: I
authors.initials: I
authors.lastname: Tomic
authors.forename: G
authors.initials: G
authors.lastname: Plavec
authors.forename: S
authors.initials: S
authors.lastname: Ilic
authors.forename: N
authors.initials: N
authors.lastname: Ilic
authors.forename: D
authors.initials: D
authors.lastname: Baskic
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000401:mortality; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D011379:Prognosis; D015996:Survival Rate
chemical_list: D010751:Phosphopyruvate Hydratase