title: Acute functional recovery of cerebral blood flow after forebrain ischemia in rat.
abstract: After complete cerebral ischemia, the postischemic blood flow response to functional activation is severely attenuated for several hours. However, little is known about the spatial and temporal extent of the blood flow response in the acute postischemic period after incomplete cerebral ischemia. To investigate the relative cerebral blood flow (rCBF) response in the somatosensory cortex of rat to controlled vibrissae stimulation after transient incomplete ischemia (15-min bilateral common carotid artery occlusion+hypotension), we employed laser speckle imaging combined with statistical parametric mapping. We found that the ischemic insult had a significant impact on the baseline blood flow (P<0.005) and the activation area in response to functional stimulation was significantly reduced after ischemia (P<0.005). The maximum rCBF response in the activation area determined from the statistical analysis did not change significantly up to 3 h after ischemia (P>0.1). However, the time when rCBF response reached its maximum was significantly delayed (P<0.0001) from 2.4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04).
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Shimazu
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Janos
authors.initials: J
authors.lastname: Luckl
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Kimberg
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Xiao-Han
authors.initials: XH
authors.lastname: Chen
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
authors.forename: Joel H
authors.initials: JH
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005073:Evoked Potentials, Somatosensory; D016548:Prosencephalon; D051381:Rats; D020127:Recovery of Function / Q000502:physiology*; D012039:Regional Blood Flow