title: Methamphetamine induces chronic corticostriatal depression: too much of a bad thing.
abstract: Leading theories of drug addiction propose that repeated drug exposure produces a long-lasting homeostatic dysregulation in brain reward processing that is normalized by drug readministration. In this issue of Neuron, Bamford and colleagues describe a novel neurobiological substrate that may contribute to this effect.
authors.affiliation: Department of Psychology, University of North Carolina at Chapel Hill, CB# 3270, Davie Hall, Chapel Hill, NC 27599-3270, USA.
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Day
authors.forename: Regina M
authors.initials: RM
authors.lastname: Carelli
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000187:drug effects* / Q000502:physiology; D008694:Methamphetamine / Q000009:adverse effects* / Q000494:pharmacology*; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology
chemical_list: D008694:Methamphetamine