[Calculation of paternity index for paternity testing with considering mutation].
OBJECTIVE
To formulate recommendations in calculation of paternity index in paternity testing under considering mutations.


METHODS
Different formulas under considering mutations were developed according to Brenner method.


RESULTS
Different formulas under considering mutations were obtained. Both true exclusion and false exclusion of paternity were easily distinguished using these formulas when the genetic pattern was inconsistent with paternity.


CONCLUSIONS
The scientific evidence for paternity testing can be obtained using these formulas under considering mutations when both the combined probability of exclusion and the paternity index meet the threshold values. However, when either the combined probability of exclusion or the paternity index can not meet the threshold values, more genetic markers should be added.
Hou
Yi-ping
YP
Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. forensic@scu.edu.cn
Wu
Jin
J
Yan
Jin
J
D005260:Female; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation; D010334:Paternity