Synthesis and application of chiral beta-amino disulfides as ligands for the enantioselective addition of diethylzinc to aldehydes.
A new class of chiral beta-amino disulfides was synthesized from readily available and inexpensive starting materials by a straightforward method and their abilities as ligands were examined in the enantioselective addition of diethylzinc to aldehydes. Enantiomeric excesses of up to 99% have been obtained using 0.5 mol % of the chiral catalysts.
Braga
Antonio L
AL
Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. albraga@quimica.ufsm.br
Galetto
Fábio Z
FZ
Rodrigues
Oscar E D
OE
Silveira
Claudio C
CC
Paixão
Marcio W
MW