Novel roles for Nogo receptor in inflammation and disease.
The Nogo receptor (NgR), which was identified as a common receptor for three axon growth inhibitors associated with myelin, has been extensively characterized for its role in triggering growth cone collapse and arresting neurite/axon growth. Recent studies indicate that NgR is also expressed in nonneuronal cells and modulates macrophage responses during inflammation after peripheral nerve injury. In this article, we discuss the possibility that NgR might have wider effects on inflammation in a variety of neurological conditions ranging from central nervous system trauma to diseases such as multiple sclerosis or Alzheimer's disease.
David
Samuel
S
Center for Research in Neuroscience, The Research Institute of the McGill University Health Center, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada. sam.david@mcgill.ca
Fry
Elizabeth J
EJ
López-Vales
Rubèn
R
D000544:Alzheimer Disease / Q000276:immunology / Q000473:pathology; D000818:Animals; D004789:Enzyme Activation; D058851:GPI-Linked Proteins; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D017628:Microglia / Q000378:metabolism; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000276:immunology / Q000473:pathology; D014855:Wallerian Degeneration / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D058851:GPI-Linked Proteins; D009185:Myelin Proteins; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; C000603199:RTN4 protein, human; C486580:RTN4R protein, human; D011956:Receptors, Cell Surface; D020741:rho GTP-Binding Proteins