title: [Lack of association between the APOE genotype and the response to statin treatment in patients with acute ischemic episodes].
abstract: OBJECTIVE
  APOE genotype has been shown to have an influence on lipid concentrations. However, its relation with response to lipid-lowering treatment is not well established. The aim of our work was to analyze whether this genotype is associated with changes in the lipid profile in response to statins treatment.
  
  
  METHODS
  A total of 222 consecutive patients with acute ischemic episodes and subjected to treatment with statins were included in a retrospective study. The patients' lipid profile was determined at the first visit to the Lipids Unit and after one year on a statin regime. APOE genotypes were determined by PCR-RFLP, and separated in three groups: E2 (E2 carriers), E4 (E4 carriers) and E3 (E3/E3). E2/E4 patients were not included in the study.
  
  
  RESULTS
  Relative frequencies of alleles epsilon2, epsilon3 and epsilon4 were 10.5%, 70.9% and 18.6% respectively. Significant differences among groups (p = 0.039) were observed for c-LDL concentrations. E2 group had lower c-LDL than E3 group (p = 0.017) and E4 group (p = 0.01). No significant differences in c-LDL, c-HDL and c-HDL/CT were observed among the three groups with regard to variation after statin treatment.
  
  
  CONCLUSIONS
  APOE genotype does not significantly affect the lipid response in patients with acute ischemic episodes after statin treatment.
authors.affiliation: Laboratorio de Bioquímica Hormonal y Génica, Hospital Universitario de Bellvitge, Barcelona, Spain. marinez@farmacia.ufmg.br
authors.forename: Marinez Oliveira
authors.initials: MO
authors.lastname: Sousa
authors.forename: Emilio
authors.initials: E
authors.lastname: Corbella
authors.forename: Pedro
authors.initials: P
authors.lastname: Alía
authors.forename: Jordi
authors.initials: J
authors.lastname: Cámara
authors.forename: María José
authors.initials: MJ
authors.lastname: Castro
authors.forename: Xavier
authors.initials: X
authors.lastname: Pintó
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Navarro
mesh_terms: D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
chemical_list: D001057:Apolipoproteins E; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors