title: Strain distribution pattern of immune nephritis--a follow-up study.
abstract: Previous studies have indicated that the NZW, DBA/1, 129/sv and BUB strains are particularly sensitive to experimental anti-glomerular basement membrane (GBM)-induced immune nephritis. The present study extends previous observations by examining eight additional inbred mouse strains for their susceptibility to immune nephritis. Unlike the ALR/Lt, CAST/Ei, DDY/JclSidSeyFrk, FVB/NJ, PERA/Ei, SB/Le and BALB/c strains, the C58 mouse strain was observed to be particularly susceptible to experimental immune nephritis, with CBA mice being a close second. In contrast to the other strains, C58 mice uniformly developed heavy proteinuria, azotemia and severe glomerulonephritis with prominent crescent formation and tubulointerstitial nephritis following challenge with anti-GBM sera. These differences were associated with increased murine Ig deposition, leukocyte infiltration and IFN-gamma production within the kidneys of C58 mice. Studies aimed at elucidating the genetic factors and molecular pathways responsible for the enhanced renal disease in C58 mice are warranted.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Xie
authors.forename: Ziaur S M
authors.initials: ZS
authors.lastname: Rahman
authors.forename: Shangkui
authors.initials: S
authors.lastname: Xie
authors.forename: Jiankun
authors.initials: J
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Du
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Qin
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Xin J
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Chandra
authors.initials: C
authors.lastname: Mohan
mesh_terms: D000818:Animals; D017849:Animals, Inbred Strains / Q000235:genetics*; D019867:Anti-Glomerular Basement Membrane Disease / Q000235:genetics* / Q000276:immunology; D000910:Antibodies, Heterophile / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D007116:Immunization, Passive; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D051379:Mice; D011507:Proteinuria / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D013045:Species Specificity
chemical_list: D000910:Antibodies, Heterophile; D001323:Autoantibodies; D007371:Interferon-gamma