Adiponectin and left ventricular structure and function in healthy adults.
BACKGROUND
Adiponectin inhibits protein synthesis in cardiac myocytes, thereby opposing the effect of cardiac workload and trophic factors (in particular, insulin) on left ventricular (LV) mass and wall thickness (WT).


OBJECTIVE
We tested whether adiponectin and its isoforms are related to LV mass, WT, and function independently of metabolic factors.


METHODS
This was a cross-sectional study.


METHODS
The study included 77 healthy volunteers (42 men) aged 30-59 yr with normal LV structure and function.


METHODS
Insulin response and insulin sensitivity were assessed by oral glucose tolerance test and euglycemic hyperinsulinemic clamp. LV mass, WT, stroke work, chamber function, and myocardial longitudinal function were evaluated by standard Doppler echocardiography and tissue Doppler imaging. Total and molecular isoforms of adiponectin were measured in plasma.


RESULTS
By multivariate analysis, independent factors affecting LV mass were sex, body mass index, stroke work, and current smoking (R(2) = 0.66). Independent correlates of LV WT were age, stroke work, and plasma adiponectin (standardized r = 0.28, 0.41, and -0.26, P at least < 0.005, R(2) = 0.48). LV longitudinal late diastolic velocity was independently related to age, body mass index, and adiponectin (standardized r = 0.20, 0.26, -0.33, P at least < 0.05, R(2) = 0.30). High-molecular-weight adiponectin (47% of total), but not lower molecular-weight isoforms, insulin sensitivity, or other metabolic factors, was inversely and independently related to WT (standardized r = -0.27, P < 0.01) and myocardial longitudinal late diastolic velocity (standardized r = -0.28, P < 0.05).


CONCLUSIONS
In healthy subjects, circulating total and high-molecular-weight adiponectin are related to LV WT and diastolic function, independently of age and metabolic factors.
Kozakova
Michaela
M
Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy. m.kozakova@int.med.unipi.it
Muscelli
Elza
E
Flyvbjerg
Allan
A
Frystyk
Jan
J
Morizzo
Carmela
C
Palombo
Carlo
C
Ferrannini
Ele
E
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D003430:Cross-Sectional Studies; D003971:Diastole; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D020033:Protein Isoforms; D013599:Systole; D016277:Ventricular Function, Left
D052242:Adiponectin; D020033:Protein Isoforms