In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca.
Ethyl acetate (EtOAc) extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin (1), citflavanone (2), erythrisenegalone (3), lonchocarpol A (4), liquiritigenin (5), and 8-prenyldaidzein (6), were isolated from the extract. Diprenylated flavanone 4 showed a notable antimalarial activity (IC(50); 1.6 microg/mL); however 1 and 3 did not show the activity, even though these compounds possessed prenylated substitution.
Khaomek
Pranorm
P
Faculty of Science, Rangsit University, Pathumthani, 12000, Thailand.
Ichino
Chikara
C
Ishiyama
Aki
A
Sekiguchi
Hitomi
H
Namatame
Miyuki
M
Ruangrungsi
Nijsiri
N
Saifah
Ekarin
E
Kiyohara
Hiroaki
H
Otoguro
Kazuhiko
K
Omura
Satoshi
S
Yamada
Haruki
H
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D018432:Drug Resistance, Multiple; D004895:Erythrina / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D054876:Prenylation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013785:Thailand
C529776:8-prenyldaidzein; D000962:Antimalarials; D044950:Flavanones; D005419:Flavonoids; D007529:Isoflavones; D010936:Plant Extracts; C529774:citflavanone; C529775:erythrisenegalone; C448459:lupinifolin; C068505:senegalensin; C083152:liquiritigenin