Effects of ginger on gastric emptying and motility in healthy humans.
OBJECTIVE
Ginger has been reported to improve upper gastrointestinal symptoms. Little information about the effects of ginger on gastric motor function, exists, however. Our aim was to investigate the effects of ginger on gastric emptying, antral motility, proximal gastric dimensions, and postprandial symptoms.


METHODS
Twenty-four healthy volunteers were studied twice in a randomized double-blind manner. After an 8 h fast, the volunteers ingested three ginger capsules (total 1200 mg) or placebo, followed after 1 h by 500 ml low-nutrient soup. Antral area, fundus area and diameter, and the frequency of antral contractions were measured using ultrasound at frequent intervals over 90 min, and the gastric half-emptying time was calculated from the change in antral area. Gastrointestinal sensations and appetite were scored using visual analog questionnaires. Data are expressed in terms of mean+/-standard error.


RESULTS
Antral area decreased more rapidly (P<0.001) and the gastric half-emptying time was less after ginger than placebo ingestion (13.1+/-1.1 vs. 26.7+/-3.1 min, P<0.01), whereas the frequency of antral contractions was greater (P<0.005). Fundus dimensions did not differ, and there was no significant difference in any gastrointestinal symptoms.


CONCLUSIONS
Ginger accelerates gastric emptying and stimulates antral contractions in healthy volunteers. These effects could potentially be beneficial in symptomatic patient groups.
Wu
Keng-Liang
KL
Division of Hepatogastroenterology, Department of Internal Medicine, College of Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan. kengliang_wu@yahoo.com.tw
Rayner
Christopher K
CK
Chuah
Seng-Kee
SK
Changchien
Chi-Sin
CS
Lu
Sheng-Nan
SN
Chiu
Yi-Chun
YC
Chiu
King-Wah
KW
Lee
Chuan-Mo
CM
D000328:Adult; D004311:Double-Blind Method; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D020939:Zingiber officinale; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D019518:Postprandial Period; D011706:Pyloric Antrum / Q000502:physiology; D012677:Sensation / Q000187:drug effects
D010936:Plant Extracts