Direct compression properties of chitin and chitosan.
Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan were found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with the other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications.
Mir
Viviana García
VG
Institute of Pharmacy and Food, University of Havana, Cuba.
Heinämäki
Jyrki
J
Antikainen
Osmo
O
Revoredo
Ofelia Bilbao
OB
Colarte
Antonio Iraizoz
AI
Nieto
Olga Maria
OM
Yliruusi
Jouko
J
D000465:Algorithms; D000818:Animals; D002482:Cellulose; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002686:Chitin / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D005079:Excipients; D008855:Microscopy, Electron, Scanning; D008121:Nephropidae / Q000737:chemistry; D012212:Rheology
D005079:Excipients; D002686:Chitin; D002482:Cellulose; D048271:Chitosan; C109691:microcrystalline cellulose