title: Holmium laser enucleation versus transurethral resection of the prostate: results from a 2-center prospective randomized trial in patients with obstructive benign prostatic hyperplasia.
abstract: OBJECTIVE
  To our knowledge we report the first multicenter, prospective, randomized study comparing holmium laser enucleation (HoLEP) and transurethral prostate resection (TURP) for obstructive benign prostatic hyperplasia.
  
  
  METHODS
  From January to October 2002, 100 consecutive patients with symptomatic obstructive benign prostatic hyperplasia were randomized at 2 centers to surgical treatment with HoLEP (52 in group 1) or TURP (48 in group 2). Patients in the 2 groups were preoperatively assessed by scoring subjective symptoms questionnaires. Preoperative and perioperative parameters were also evaluated, the latter at 1, 6 and 12 months of followup.
  
  
  RESULTS
  At baseline all patients had obstruction (Schäfer grade greater than 2). At the 1, 6 and 12-month followups no statistically significant differences were observed between the 2 groups in terms of urodynamic findings and subjective symptom scoring. In the HoLEP group mean total time in the operating room +/- SD was significantly longer than for TURP (74 +/- 19.5 vs 57 +/- 15 minutes, p <0.05), while catheterization time (31 +/- 13 vs 57.78 +/- 17.5 minutes, p <0.001 and hospital stay (59 +/- 19.9 vs 85.8 +/- 18.9 hours, p <0.001) were significantly shorter in the HoLEP group. Transient stress and urge incontinence were more common in the HoLEP group, although at the 12-month followup results were comparable. The overall complication rate was comparable in the 2 groups. Erectile function was also maintained in the followup period from baseline in each group, as expected.
  
  
  CONCLUSIONS
  HoLEP and TURP were equally effective for relieving obstruction and lower urinary tract symptoms. HoLEP was associated with shorter catheterization time and hospital stay. At 1 year of followup complications were similar in the 2 groups.
authors.affiliation: Department of Urology, University Vita-Salute, Scientific Institute Hospital San Raffaele, Milan, Italy. montorsi.francesco@hsr.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.forename: Richard
authors.initials: R
authors.lastname: Naspro
authors.forename: Andrea
authors.initials: A
authors.lastname: Salonia
authors.forename: Nazareno
authors.initials: N
authors.lastname: Suardi
authors.forename: Alberto
authors.initials: A
authors.lastname: Briganti
authors.forename: Matteo
authors.initials: M
authors.lastname: Zanoni
authors.forename: Sergio
authors.initials: S
authors.lastname: Valenti
authors.forename: Ivano
authors.initials: I
authors.lastname: Vavassori
authors.forename: Patrizio
authors.initials: P
authors.lastname: Rigatti