title: Application of a domino Friedel-Crafts acylation/alkylation reaction to the formal syntheses of (+/-)-taiwaniaquinol B and (+/-)-dichroanone.
abstract: An efficient acid-promoted domino Friedel-Crafts (FC) acylation/alkylation reaction has been developed for the construction of the core 6,5,6-ABC tricyclic skeleton of taiwaniaquinoids. The formal total syntheses of diterpenoids (+/-)-taiwaniaquinol B and (+/-)-dichroanone based on this strategy have been achieved.
authors.affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
authors.forename: Shouchu
authors.initials: S
authors.lastname: Tang
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Xu
authors.forename: Jinmei
authors.initials: J
authors.lastname: He
authors.forename: Yongping
authors.initials: Y
authors.lastname: He
authors.forename: Jiyue
authors.initials: J
authors.lastname: Zheng
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D000215:Acylation; D000478:Alkylation; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D028321:Plant Preparations / Q000737:chemistry
chemical_list: D004224:Diterpenes; D028321:Plant Preparations; C516091:dichroanone; C505702:taiwaniaquinol B