title: Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment.
abstract: The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.
authors.affiliation: Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Gaggelli
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Grzonka
authors.forename: Henryk
authors.initials: H
authors.lastname: Kozłowski
authors.forename: Caterina
authors.initials: C
authors.lastname: Migliorini
authors.forename: Elena
authors.initials: E
authors.lastname: Molteni
authors.forename: Daniela
authors.initials: D
authors.lastname: Valensin
authors.forename: Gianni
authors.initials: G
authors.lastname: Valensin
mesh_terms: D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry*; D017433:Protein Structure, Secondary; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C084358:amyloid beta-protein (1-28); D003300:Copper