Plasmodium chabaudi: efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice.
Recent studies have proposed curcumin as a potential partner for artemisinin in artemisinin combination therapies to treat malaria infections. The efficacy of curcumin alone and in combination with artemisinin was evaluated on a clone of Plasmodium chabaudi selected for artemisinin resistance in vivo. The addition of piperine as an enhancer of curcumin activity was also tested. Results indicated that curcumin, both alone and in combination with piperine had only a modest antimalarial effect and was not able to reverse the artemisinin-resistant phenotype or significantly affect growth of the tested clone when used in combination with artemisinin. This is in contrast with previous in vivo work and calls for further experimental evaluation of the antimalarial potential of curcumin.
Martinelli
Axel
A
Centro de Malária e Outras Doenças Tropicais/IHMT/UNL/Unidade de Biologia Molecular, Rua da Junqueira 96, 1349-008 Lisbon, Portugal. amartinelli@ihmt.unl.pt
Rodrigues
Louise A
LA
Cravo
Pedro
P
D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D037621:Artemisinins / Q000008:administration & dosage / Q000494:pharmacology*; D052117:Benzodioxoles / Q000008:administration & dosage / Q000494:pharmacology; D001682:Biological Availability; D003474:Curcumin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004351:Drug Resistance / Q000187:drug effects; D004359:Drug Therapy, Combination; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D016788:Plasmodium chabaudi / Q000187:drug effects*; D053284:Polyunsaturated Alkamides / Q000008:administration & dosage / Q000494:pharmacology
D000470:Alkaloids; D000890:Anti-Infective Agents; D037621:Artemisinins; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C031327:artemisinin; D003474:Curcumin; C008922:piperine