Post-hepatectomy regeneration of the murine liver I. Effect upon Schistosoma mansoni lesions, before and after chemotherapy.
Hepatic histopathological changes due to Schistosoma mansoni infection in the mouse presented considerable improvement following partial hepatectomy, both during early (acute) and late (chronic) infections, and especially when surgery was preceded by curative chemotherapy. A 60% hepatectomy removed a great deal of a diseased liver that was replaced by a normal-looking tissue in which schistosomal lesions appeared fewer and scattered. After chemotherapy, residual fibrosis left either from cured acute and chronic schistosomal lesions, almost completely disappeared when the regenerated liver was examined a month afterwards. These marked changes, brought about by hepatectomy in experimental hepatic schistosomiasis, illustrate the fact that post-hepatectomy regeneration tends to restore the normal structure of the liver, even in a diseased organ.
Coelho
Paulo Marcos Zech
PM
FIOCRUZ, Centro de Pesquisas René Rachou, av. Augusto de Lima 1766, Belo Horizonte, MG, Brazil.
Andrade
Zilton A
ZA
de Mello
Rômulo Teixeira
RT
Costa
Guilherme
G
Dias
Flávia Sílvia Guimarães
FS
Cunha-Melo
José Renan
JR
D000818:Animals; D004358:Drug Therapy; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008115:Liver Regeneration; D051379:Mice; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000601:surgery*; D016896:Treatment Outcome