Modulation of radiation-induced biochemical changes in cerebrum of Swiss albino mice by Grewia Asiatica.
The present study evaluates the possible radioprotective effect of Grewia asiatica fruit (rich in anthocyanin, carotenes, vitamin C, etc.) pulp extract (GAE) on cerebrum of Swiss albino mice exposed to 5 Gy gamma radiation. For this, healthy mice from an inbred colony were divided into four groups: (1) Control (vehicle treated) (2) GAE treated - mice in this group were orally supplemented with GAE (700 m/kg. b.w./day) once daily for fifteen consecutive days, (3) Vehicle treated irradiated mice, and (4) GAE + Irradiated - Mice in this group received distilled water orally equivalent to GAE (700 m/kg. b.w/day) for fifteen days consecutively. Mice were sacrificed at various intervals viz. 1-30 days. Radiation-induced augmentation in the levels of lipid peroxidation of mice cerebrum was significantly ameliorated by GAE pretreatment. Radiation-induced depletion in the level of glutathione and protein was prevented significantly by GAE administration.
Sisodia
Rashmi
R
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, 302004 India. rashsisodia@yahoo.co.in.
Ahaskar
Muktika
M
Sharma
K V
KV
Singh
Smita
S
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000528:radiation effects; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays / Q000009:adverse effects; D005978:Glutathione / Q000378:metabolism; D032382:Grewia / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013858:Thiobarbiturates / Q000378:metabolism
D010936:Plant Extracts; D011837:Radiation-Protective Agents; D013858:Thiobarbiturates; D005978:Glutathione; C029684:thiobarbituric acid