44-2C cells a neuroendocrine model to study neuropeptide, oncogene, and growth factor gene regulation.
The neuroendocrine 44-2C cells synthesize, secrete, and manifest differential regulation of calcitonin (CT), CT gene-related peptide (CGRP), neurotensin (NT), and somatostatin (SS). These cells maintain differentiated function when grown in serum-free, growth factor and hormone-deprived milieu. The cells continue to secrete CT, CGRP, NT, and SS and differentially respond to cellular secretagogues. In serum-free cultures, the cells produce biologically active acidic fibroblast growth factor (aFGF) and differentially regulate the expression of the protooncogene fos (c-fos).
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UCSD Medical School, Neuroendocrinology Laboratory, Basic Science Building M-003, La Jolla, CA 92093, USA.