title: Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways.
abstract: Angiotensin II (AngII)( *) is the main effector of the renin-angiotensin system and influences cell growth, migration, differentiation, and apoptosis. The mitogen-activated protein (MAP) kinase family of serine-threonine kinases integrates diverse extracellular stimuli and is involved in the regulation of cell growth and apoptosis. AngII regulates activity of the MAP kinase family members extracellular regulated kinases (ERK1/2) and c-Jun N-terminal kinase (JNK). This review discusses the signal transduction pathways leading to ERK1/2 and JNK activation by AngII.
authors.affiliation: Department of Medicine, Cardiology Division, University of Washington, Seattle, WA 98195, USA.
authors.forename: U
authors.initials: U
authors.lastname: Schmitz
authors.forename: B C
authors.initials: BC
authors.lastname: Berk