Ontogeny of thyrotropin-releasing hormone biosynthesis and release in hypothalamic neurons.
Thyrotropin-releasing hormone (TRH) is expressed at early postmitotic stages of hypothalamic neuron development, in the mouse and rat, as revealed by the presence of the mature peptide, of pro-TRH mRNAs, and of large precursor forms. This indicates a coordinate expression of several genes encoding, respectively, pro-TRH, its processing enzymes, and the cell machinery for intracellular transport, sorting, and release of TRH. During development, an acceleration of pro-TRH processing is revealed by an increased proportion of the mature peptide. This is correlated with changes in the respective distribution of pro-TRH and TRH along neurites and the ontogenesis of neurosecretory granules.
Tixier-Vidal
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Cellular and Molecular Endocrinology Group, URA CNRS 1115, College of France, Paris Cedex 5, France.
Faivre-Bauman
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