title: Metabolic modulation of inflammation-induced activation of coagulation.
abstract: The bidirectional interaction between coagulation and inflammation, which is relevant in various disease states that are dominated by systemic inflammatory responses, such as severe infection or chronic vascular disease, is modulated by metabolic factors. Changes in lipoprotein metabolism affect the inflammation-induced activation of coagulation, which may have impact on downstream effects, including organ dysfunction and survival. Likewise, glucose and insulin seem to influence inflammation-induced effects on coagulation and fibrinolysis. Hyperglycemia affects inflammation-induced and tissue factor-driven activation of coagulation, whereas hyperinsulinemia modulates the fibrinolytic response. There are indications that this modulatory role of metabolic factors in inflammation and coagulation may also have an impact on clinical outcome in various disease states.
authors.affiliation: Department of Vascular Medicine/Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. m.m.levi@amc.uva.nl
authors.forename: Marcel
authors.initials: M
authors.lastname: Levi
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
authors.forename: Erik
authors.initials: E
authors.lastname: Stroes
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008954:Models, Biological; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins