Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats.
Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-alpha activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.
Cho
Wan-Seob
WS
National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea.
Han
Beom Seok
BS
Ahn
Byeongwoo
B
Nam
Ki Taek
KT
Choi
Mina
M
Oh
Sang Yeon
SY
Kim
Seung Hee
SH
Jeong
Jayoung
J
Jang
Dong Deuk
DD
D000818:Animals; D015153:Blotting, Western; D001835:Body Weight / Q000187:drug effects; D015197:Carcinogenicity Tests; D002273:Carcinogens; D002374:Catalase / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D009929:Organ Size / Q000187:drug effects; D020025:Peroxisome Proliferators / Q000633:toxicity*; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics; D016019:Survival Analysis
D002273:Carcinogens; D020025:Peroxisome Proliferators; D010795:Phthalic Acids; D002374:Catalase; C042080:diisodecyl phthalate