Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study.
OBJECTIVE
Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke.


METHODS
Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study.


RESULTS
The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes.


CONCLUSIONS
The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.
Hagiwara
N
N
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kitazono
T
T
Kamouchi
M
M
Kuroda
J
J
Ago
T
T
Hata
J
J
Ninomiya
T
T
Ooboshi
H
H
Kumai
Y
Y
Yoshimura
S
S
Tamaki
K
K
Fujii
K
K
Nagao
T
T
Okada
Y
Y
Toyoda
K
K
Nakane
H
H
Sugimori
H
H
Yamashita
Y
Y
Wakugawa
Y
Y
Kubo
M
M
Tanizaki
Y
Y
Kiyohara
Y
Y
Ibayashi
S
S
Iida
M
M
D000368:Aged; D020520:Brain Infarction / Q000145:classification / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012042:Registries; D012189:Retrospective Studies; D012306:Risk; D012307:Risk Factors
D008840:Microfilament Proteins; C432967:SORBS1 protein, human