Corticostatins.
Corticostatic (anti-ACTH) peptides were first isolated from rabbit fetal and adult lung and from rabbit neutrophils. They have now been isolated from human, rat, and guinea pig tissues. They have several biologic activities that include inhibition of ACTH binding, stimulation of L-type Ca(2+) channels, monocyte chemotaxis, and degranulation of mast cells with the release of histamine. Rabbit corticostatin I (CSI) is widely distributed in maternal and fetal rabbit tissues and is localized to neutrophils, macrophages, and monocytes, and the changing concentration of CSI with advancing gestation indicates a possible physiologic role during pregnancy.
Solomon
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Endocrine Laboratory, Royal Victoria Hospital and Departments of Biochemistry, Medicine and Obstetrics and Gynecology, McGill University, Montreal, Quebec H3A IAl, Canada.