[Impact of anxiety-depression symptoms on clinical recovery and serum TNF-alpha and IL-6 of patients with burns].
OBJECTIVE
To investigate the impact of anxiety-depression symptoms on the healing of burn wounds and the serum tumor necrosis factor a (TNF-alpha) and interleukin-6 (IL-6) in the patients with moderate and severe burns.


METHODS
The patients with moderate and severe burns were divided into anxiety-depression group (24 patients) and non-anxiety-depression group (27 patients)according to the scores of anxiety-depression scores three days after burn measured by Hamilton Rating Scale for Depression (HAMD) and Hamilton Rating Scale for Anxiety (HAMA). The routine therapy was applied for both groups for 30 days. Then the scores of anxiety and depression and the degrees of wound healing were examined. The serum TNF-alpha IL-6 were measured with enzyme linked immunosorbent assay (ELISA).


RESULTS
No significant decrease of the scores of depression was found before and after treatments in the anxiety-depression group (P > 0.05). The days that were needed for healing the wounds and the serum TNF-alpha and IL-6 increased in the patients with depression compared with the control group (P < 0.05).


CONCLUSIONS
There are anxious and depressive reactions to burns by the patients. The continuous negative emotion can induce the increase of serum TNF-alpha and IL-6 and lead to delay of the healing of the burn wounds.
Wu
Xiao-ping
XP
Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang
Dong
D
Song
Zhong-jin
ZJ
Sun
Cong-zhou
CZ
Xiao
Xiao-lan
XL
He
You-de
YD
Wang
Cai-ming
CM
Sun
Xue-li
XL
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000209:etiology*; D002056:Burns / Q000097:blood* / Q000150:complications; D002648:Child; D003863:Depression / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014945:Wound Healing; D055815:Young Adult
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha