title: Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips.
abstract: The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine (Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, alpha-difluoromethylornithine (DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) (MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.
authors.affiliation: Department of Biology, Arts and Sciences Faculty, Marmara University, Goztepe 81040, Istanbul, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Unal
authors.forename: Narcin
authors.initials: N
authors.lastname: Palavan-Unsal
authors.forename: M A
authors.initials: MA
authors.lastname: Tufekci
mesh_terms: D003513:Cycloheximide / Q000494:pharmacology; D000518:Eflornithine / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018519:Meristem / Q000166:cytology / Q000187:drug effects*; D008935:Mitoguazone / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects* / Q000502:physiology; D019697:Onions / Q000187:drug effects* / Q000502:physiology; D011073:Polyamines / Q000494:pharmacology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D011700:Putrescine / Q000494:pharmacology; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D011073:Polyamines; D011500:Protein Synthesis Inhibitors; D013096:Spermine; D003513:Cycloheximide; D008935:Mitoguazone; D013095:Spermidine; D011700:Putrescine; D000518:Eflornithine