Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.
BACKGROUND
We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina.


METHODS
All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina.


RESULTS
All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P < .05).


CONCLUSIONS
Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis.
Ziakas
Antonios
A
1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece. aziakas@med.auth.gr
Gavrilidis
Stavros
S
Souliou
Efthimia
E
Giannoglou
George
G
Stiliadis
Ioannis
I
Karvounis
Haralambos
H
Efthimiadis
George
G
Mochlas
Sotirios
S
Vayona
M Arvanitidou
MA
Hatzitolios
Apostolos
A
Savopoulos
Christos
C
Pidonia
Ifigenia
I
Parharidis
George
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D002570:Ceruloplasmin / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors; D020107:Troponin T / Q000097:blood; D015854:Up-Regulation
D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D020107:Troponin T; D005340:Fibrinogen; D002097:C-Reactive Protein; D002570:Ceruloplasmin