title: Role of hypaphorine in the toxicity of Astragalus lusitanicus.
abstract: Hypaphorine, an alpha-N,N,N-trimethyltryptophan betaine, was isolated, for the first time, from Astragalus lusitanicus Lam. (Fabaceae), a plant highly toxic for lambs and goats. This alkaloid was characterized by NMR and MS analysis. Hypaphorine was previously reported to be a convulsive poison. To confirm the toxicity, it was synthesized and tested in goats. Hypaphorine was shown to be non-toxic for goats even at a high dose of 2 g kg(-1) by oral administration.
authors.affiliation: Département de Pharmacie Toxicologie et Biochimie, Institut Agronomique et Vétérinaire Hassan II BP 6202, Rabat-Instituts, Morocco.
authors.forename: Hakima
authors.initials: H
authors.lastname: Bel-Kassaoui
authors.forename: Driss
authors.initials: D
authors.lastname: Lamnaouer
authors.forename: Akino
authors.initials: A
authors.lastname: Jossang
authors.forename: El Hassane
authors.initials: el H
authors.lastname: Abdennebi
authors.forename: Zoubida
authors.initials: Z
authors.lastname: Charrouf
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
mesh_terms: D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry*; D001681:Biological Assay; D006041:Goats; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D010947:Plants, Toxic / Q000737:chemistry*
chemical_list: D007211:Indoles; D010936:Plant Extracts; C001529:lenticin