Renal cell carcinoma with unusual metastasis to the gallbladder.
Gallbladder involvement in patients with renal cell carcinoma (RCC) is extremely rare. We present a report of a 61-year-old man with a synchronous RCC metastasis to the gallbladder presenting as an intraluminal polypoid mass simulating primary gallbladder carcinoma. Enhanced abdominal computed tomography demonstrated a well-enhanced polypoid lesion in the gallbladder. Intraoperative rapid pathological examination of the gallbladder tumor showed clear cell-type cancerous cells. Microscopically, tumor cells of both the resected kidney and gallbladder had round uniform nuclei, clear cytoplasm, and well-defined cytoplasmic borders, forming alveolar patterns. Immunohistochemically, the tumor cells were negative for cytokeratin 7 (CK7) and carcinoembryonic antigen (CEA), which is usually positive in primary clear cell carcinoma of the gallbladder. Therefore, the final diagnosis was RCC with a synchronous gallbladder metastasis.
Nojima
Hiroyuki
H
Department of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666-2 Nitona-chou, Chuo-ku, Chiba 260-8717, Japan.
Cho
Akihiro
A
Yamamoto
Hiroshi
H
Nagata
Matsuo
M
Takiguchi
Nobuhiro
N
Kainuma
Osamu
O
Souda
Hiroaki
H
Gunji
Hisashi
H
Miyazaki
Akinari
A
Ikeda
Atsushi
A
Matsumoto
Ikuko
I
Asano
Takehide
T
Ryu
Munemasa
M
Nihei
Naoki
N
Maruoka
Masayuki
M
D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery; D002763:Cholecystectomy; D005706:Gallbladder Neoplasms / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009392:Nephrectomy