title: Hemophagocytic syndrome in Dengue hemorrhagic fever with severe multiorgan complications.
abstract: A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G. The authors believe that HPCS are not infrequently seen with high mortality and recommended early diagnosis and treatment with the regimen. This is the first complete report of hemophagocytic syndrome in adult dengue hemorrhagic fever in Thailand. The literature of HPCS in DHF was reviewed and discussed.
authors.affiliation: Department of Medicine, Vichaiyut Hospital, Bangkok, Thailand.
authors.forename: Tanomsri
authors.initials: T
authors.lastname: Srichaikul
authors.forename: Sompone
authors.initials: S
authors.lastname: Punyagupta
authors.forename: Termkiat
authors.initials: T
authors.lastname: Kanchanapoom
authors.forename: Chow
authors.initials: C
authors.lastname: Chanokovat
authors.forename: Kanchit
authors.initials: K
authors.lastname: Likittanasombat
authors.forename: Apichai
authors.initials: A
authors.lastname: Leelasiri
mesh_terms: D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D012307:Risk Factors; D019595:Severe Dengue / Q000150:complications* / Q000503:physiopathology; D013785:Thailand
chemical_list: D007074:Immunoglobulin G; D005665:Furosemide; D003907:Dexamethasone