title: [The impact of patient and tumor related prognostic factors on survival in non-medullary differentiated thyroid cancer. A study of 125 cases].
abstract: The aim of the study was to assess the impact of patient--(age) and tumor--related factors (size, extrathyroidal invasion, distant metastasis, multicentricity and lymphatic metastasis) on survival of patients with differentiated thyroid cancer (DTC).
  
  
  METHODS
  A clinical retrospective study was carried out on a series of 125 patients operated for non medullary DTC in the IIIrd Surgical Unit, in the period 1990-2005. The disease specific survival (DS) was calculated using the Kaplan Meyer method and Cox regression univariate and multivariate analysis was used to assess the impact of prognostic factors on DS.
  
  
  RESULTS
  The actual DS at 5, 10, and 15 yrs was 81.3%. Clinicopathological factors significant on univariate and multivariate regression were age over 45 yrs (p = .01), tumor size > 4 cm (p = .00), macroscopical extrathyroidal invasion (p = .000) and distant metastasis (p = .000).
authors.affiliation: Clinica a III-a Chirurgie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa", Iaşi.
authors.forename: R
authors.initials: R
authors.lastname: Dănilă
authors.forename: Ramona
authors.initials: R
authors.lastname: Popovici
authors.forename: Al
authors.initials: A
authors.lastname: Grigorovici
authors.forename: Lidia
authors.initials: L
authors.lastname: Ionescu
authors.forename: D
authors.initials: D
authors.lastname: Timofte
authors.forename: L
authors.initials: L
authors.lastname: Lefter
authors.forename: L V
authors.initials: LV
authors.lastname: Boiculesei
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Ungureanu
authors.forename: Cr
authors.initials: C
authors.lastname: Dragomir
mesh_terms: D000367:Age Factors; D018265:Carcinoma, Papillary, Follicular / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome