Iron-catalyzed direct arylation through directed C-H bond activation.
An iron-catalyzed C-C bond formation reaction of a nitrogen-containing aromatic compound with an arylzinc reagent takes place at 0 degrees C in a good to quantitative yield. The reaction involves a C-H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1,10-phenanthroline, tetramethylethylenediamine, and 1,2-dichloro-2-methylpropane, in the absence of which a very low product yield was observed.
Norinder
Jakob
J
Department of Chemistry, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Matsumoto
Arimasa
A
Yoshikai
Naohiko
N
Nakamura
Eiichi
E