title: Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking.
authors.affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.forename: Tat-Shing
authors.initials: TS
authors.lastname: Lai
authors.forename: Fung-Yi
authors.initials: FY
authors.lastname: Chan
authors.forename: Wai-Hong
authors.initials: WH
authors.lastname: Chung
authors.forename: R
authors.initials: R
authors.lastname: Abagyan
authors.forename: Yun-Chung
authors.initials: YC
authors.lastname: Leung
authors.forename: Kwok-Yin
authors.initials: KY
authors.lastname: Wong
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D001667:Binding, Competitive; D002942:Circular Dichroism; D003198:Computer Simulation; D004247:DNA / Q000187:drug effects; D019992:Databases as Topic; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes / Q000187:drug effects*; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C530381:1H-pyrazole-3-carboxy-4-methyl-5-phenyl-(1H-indol-3-ylmethylene)hydrazide; D000970:Antineoplastic Agents; D006835:Hydrazones; D008024:Ligands; D011720:Pyrazoles; D004247:DNA