Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.
The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.
Abel
Ted
T
University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA.
Nguyen
Peter V
PV
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D008568:Memory / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D017868:Cyclic AMP-Dependent Protein Kinases