title: Numerical design of experiment for sensitivity analysis--application to skin burn injury prediction.
abstract: Temperature evolution and skin burn process resulting from a laser radiation exposure are investigated in this paper. Transient temperature in skin is numerically estimated using a 1-D multilayered model based on Penne's equation. The degree of burn injury is numerically evaluated by using an Arrhenius-type function. Unfortunately, most of the mathematical model parameters are not well defined in literature. Thus, a sensitivity analysis has been performed in order to evaluate the effect of each parameters inaccuracy on temperature estimation and on burn injuries prediction (according to several authors' characterization). Investigated parameters uncertainties that crucially invalidate the thermal model are as follows: epidermis and dermis volumetric heat, extinction coefficient, and skin thickness of the affected area. Considering the damage prediction, the activation energy is a key parameter for the validation of an efficient predictive tool.
authors.affiliation: CEP-EHF, Font-Romeu Cedex 66121, France. autrique@moniut.univ-bpclermont.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Autrique
authors.forename: Corine
authors.initials: C
authors.lastname: Lormel
mesh_terms: D000465:Algorithms; D002056:Burns / Q000209:etiology* / Q000503:physiopathology*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007834:Lasers / Q000009:adverse effects*; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D011379:Prognosis; D011829:Radiation Dosage; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012867:Skin / Q000293:injuries* / Q000503:physiopathology* / Q000528:radiation effects; D012881:Skin Temperature / Q000528:radiation effects*