Porphyrin-carbohydrate conjugates: impact of carbohydrate moieties in photodynamic therapy (PDT).
In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published. Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing target-specific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.
Zheng
Xiang
X
Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Pandey
Ravindra K
RK
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009369:Neoplasms / Q000628:therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002241:Carbohydrates; D017319:Photosensitizing Agents; D011166:Porphyrins; C006969:chlorin