title: Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein.
abstract: OBJECTIVE
  To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP).
  
  
  METHODS
  One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared.
  
  
  RESULTS
  The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower.
  
  
  CONCLUSIONS
  ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.
authors.affiliation: Department of Hepato-Biliary-Pancreato-Vascular Surgery, The First Xiamen Hospital, Fujian Medical University, Xiamen, China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Zhou
authors.forename: Jia-Mei
authors.initials: JM
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Zheng-Feng
authors.initials: ZF
authors.lastname: Yin
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000821:virology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology* / Q000821:virology; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000821:virology; D005260:Female; D006515:Hepatitis B virus / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000166:cytology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013234:Stem Cells / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins