Illuminating the black box of reprogramming.
Yamanaka and colleagues, in a Science article currently published online, have generated induced pluripotent stem (iPS) cells from liver and stomach cells, suggesting that transcription factor-induced reprogramming is not restricted to particular cell types (Aoi et al., 2008). These results also provide important insight into the mechanistic basis of reprogramming.
Sridharan
Rupa
R
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Plath
Kathrin
K
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D065150:Cellular Reprogramming; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology*; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors