title: Influence of expert clinical adviser characteristics on opinions about interventional procedures.
abstract: OBJECTIVE
  The aim of this study was to examine potential associations between the professional background and experience of expert clinicians and their opinions about the clinical utility of interventional procedures.
  
  
  METHODS
  A retrospective survey of expert clinician characteristics and their opinions was conducted. Information was collected on expert clinical adviser self-declared "operator," "researcher," and conflict of interest status. Associations were sought between expert clinical adviser characteristics and their opinions on whether procedures were "established," "efficacious," and "safe." The setting was the Interventional Procedures Programme of the UK's National Institute for Health and Clinical Excellence (NICE). A total of 598 expert clinician questionnaires relating to 182 different interventional procedures were analyzed.
  
  
  RESULTS
  Expert clinical advisers with operative experience of procedures were significantly more likely to consider them as established (odds ratio [OR] 3.93; 95 percent confidence interval [CI], 2.43 to 6.36; p < .001), efficacious (OR 1.76; 95 percent CI, 1.00 to 3.08; p = .049), and safe (OR 2.28; 95 percent CI, 1.43 to 3.65; p = .001). Once adjusted for other characteristics, there was no association between either researcher or conflict of interest status and opinions about the clinical utility of procedures.
  
  
  CONCLUSIONS
  Expert clinical advisers are an important source of information for decision makers producing guidance about the use of procedures, especially when published evidence is sparse or of poor quality. This study suggests that those who are operators, but not those who are researchers or declare a conflict of interest, are more likely to have a favorable opinion of a procedure's clinical utility. Use of expert clinical advisers with a variety of experience and backgrounds seems a reasonable approach to obtaining authoritative opinions about interventional procedures, to supplement and help interpret evidence from published data.
authors.affiliation: National Institute for Health and Clinical Excellence, London, UK. georgios.lyratzopoulos@nice.org.uk
authors.forename: Georgios
authors.initials: G
authors.lastname: Lyratzopoulos
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Hoy
authors.forename: Darmarajah
authors.initials: D
authors.lastname: Veeramootoo
authors.forename: Nava V
authors.initials: NV
authors.lastname: Shanmuganathan
authors.forename: Bruce
authors.initials: B
authors.lastname: Campbell
mesh_terms: D016265:Conflict of Interest; D004059:Diffusion of Innovation; D005104:Expert Testimony; D006801:Humans; D007600:Judgment; D012108:Research Personnel; D012189:Retrospective Studies; D013673:Technology Assessment, Biomedical