title: Sinus bradycardia associated with daclizumab in liver transplant recipients: report of 3 cases.
abstract: Daclizumab is a commonly used immunosuppressive agent for prophylaxis of solid organ rejection. Although rare, the cardiovascular adverse effects of daclizumab include sinus tachycardia, hypotension, and hypertension. Here, we report 3 patients who developed significant and prolonged sinus bradycardia after receiving daclizumab following orthotopic liver transplant. Daclizumab should be considered a possible cause of bradycardia following its administration in orthotopic liver transplant.
authors.affiliation: Department of Surgery, Division of Critical Care Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA. adel.bassily-marcus@mssm.edu
authors.forename: Adel
authors.initials: A
authors.lastname: Bassily-Marcus
authors.forename: Roopa
authors.initials: R
authors.lastname: Kohli-Seth
authors.forename: Andrew
authors.initials: A
authors.lastname: Leibowitz
authors.forename: Victor
authors.initials: V
authors.lastname: Murgolo
authors.forename: John
authors.initials: J
authors.lastname: Oropello
authors.forename: Anthony
authors.initials: A
authors.lastname: Manasia
authors.forename: Ernest
authors.initials: E
authors.lastname: Benjamin
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D001919:Bradycardia / Q000139:chemically induced*; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D015209:Cholangitis, Sclerosing / Q000601:surgery; D000077561:Daclizumab; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000601:surgery; D008107:Liver Diseases / Q000601:surgery; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation; D008297:Male
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D000077561:Daclizumab