title: Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis.
abstract: The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent results on the function of TLR4, TLR2 and the MyD88 adaptor molecule in the pathogenesis of paracoccidioidomycosis are presented.
authors.affiliation: Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil. vlcalich@icb.usp.br
authors.forename: Vera L G
authors.initials: VL
authors.lastname: Calich
authors.forename: Adriana
authors.initials: A
authors.lastname: Pina
authors.forename: Maíra
authors.initials: M
authors.lastname: Felonato
authors.forename: Simone
authors.initials: S
authors.lastname: Bernardino
authors.forename: Tania A
authors.initials: TA
authors.lastname: Costa
authors.forename: Flávio V
authors.initials: FV
authors.lastname: Loures
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D053594:Myeloid Differentiation Factor 88 / Q000276:immunology*; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology*; D051195:Toll-Like Receptor 2 / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000276:immunology*
chemical_list: C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4