Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women.
We investigated the association between soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels and obesity in older women. Fifty-one postmenopausal women (10 lean, 22 overweight, and 19 obese) were included in this small retrospective analysis. Plasma sLOX-1 levels were measured using a chemiluminescent enzyme-linked immunoassay. Plasma levels of sLOX-1 were significantly higher in obese women (55.33 +/- 4.49 pg/ml) compared to lean (30.91 +/- 6.19 pg/ml, P = 0.002) and overweight women (38.31 +/- 4.18 pg/ml, P = 0.017). Plasma sLOX-1 levels were positively associated with body weight, BMI, total body fat, and trunk fat. The relationship between sLOX-1 and BMI was attenuated after adjustment for age, hormone replacement therapy, and body fat. In conclusion, obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue.
Brinkley
Tina E
TE
Department of Kinesiology, University of Maryland, College Park, Maryland, USA. tiellis@wfubmc.edu
Kume
Noriaki
N
Mitsuoka
Hirokazu
H
Phares
Dana A
DA
Hagberg
James M
JM
D000273:Adipose Tissue; D050154:Adiposity; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D012189:Retrospective Studies; D051127:Scavenger Receptors, Class E / Q000097:blood*; D013851:Thinness / Q000097:blood
C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E