Local extragonadal roles of activins.
Activins were initially isolated from gonadal fluids based on their ability to stimulate FSH secretion from gonadotropes of the anterior pituitary. They represent a group of homo/heterodimeric proteins that are structurally related to the transforming growth factor beta superfamily of growth and differentiation factors. The importance of activins as autocrine and paracrine modulators of a diverse set of biologic functions is now appreciated based on their widespread anatomic distribution and numerous biologic activities.
Bilezikjian
L M
LM
Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA.
Vale
W W
WW