Biosynthesis of enediyne antitumor antibiotics.
The enediyne polyketides are secondary metabolites isolated from a variety of Actinomycetes. All members share very potent anticancer and antibiotic activity, and prospects for the clinical application of the enediynes has been validated with the recent marketing of two enediyne derivatives as anticancer agents. The biosynthesis of these compounds is of interest because of the numerous structural features that are unique to the enediyne family. The gene cluster for five enediynes has now been cloned and sequenced, providing the foundation to understand natures' means to biosynthesize such complex, exotic molecules. Presented here is a review of the current progress in delineating the biosynthesis of the enediynes with an emphasis on the model enediyne, C-1027.
Van Lanen
Steven G
SG
Division of Pharmaceutical Sciences, University of Wisconsin, Madison, WI, 53705. bshen@pharmacy.wisc.edu
Shen
Ben
B
D039903:Actinobacteria / Q000737:chemistry / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry; D053281:Enediynes / Q000737:chemistry* / Q000378:metabolism*; D005810:Multigene Family; D048630:Polyketide Synthases / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D053281:Enediynes; D048630:Polyketide Synthases