title: Adrenal insufficiency following traumatic brain injury in adults.
abstract: OBJECTIVE
  Hypoadrenalism occurs in approximately 25% of patients soon after traumatic brain injury. Neurosurgeons or critical care physicians should be prepared to diagnose and treat this and other related hormonal deficiencies.
  
  
  RESULTS
  The severity of traumatic brain injury, location of basilar skull fractures and edema or hemorrhage within the hypothalamic-pituitary axis appear correlated with secondary adrenal failure. Primary hypoadrenalism also may occur due to injury-related systemic inflammation. Hypotension requiring vasoactive drug support, hyponatremia and hypoglycemia may be corresponding clinical signs. Evaluation of either primary or secondary hypoadrenalism should include measurement of basal and post-adrenocorticotropin stimulation cortisol blood concentrations. If the basal cortisol is under 15 microg/dl or increases by over 9 microg/dl after stimulation treatment should be considered. Intravenous hydrocortisone at 50-100 mg every 8 h or by continuous infusion is usually sufficient but may be supplemented with a mineralocorticoid if hyponatremia persists. All patients sustaining severe traumatic brain injury should be tested for endocrine failure (adrenal, thyroid and growth hormone) 3 months after injury.
  
  
  CONCLUSIONS
  Adrenal gland failure or the inability to produce adrenocorticotropin and other pituitary hormones may occur early after traumatic brain injury. Acute treatment of either cause of hypoadrenalism may correct associated hypotension, hypoglycemia, or hyponatremia.
authors.affiliation: Department of Neurosurgery, University of Texas Medical School, Houston, Texas 77030, USA. david.j.powner@uth.tmc.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Powner
authors.forename: Cristina
authors.initials: C
authors.lastname: Boccalandro
mesh_terms: D000309:Adrenal Insufficiency / Q000209:etiology*; D000328:Adult; D001930:Brain Injuries / Q000150:complications*; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D014947:Wounds and Injuries / Q000150:complications