title: Lynch syndrome in colorectal cancer patients.
abstract: Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is the most common form of hereditary colorectal cancer. It is characterized by early onset of colorectal cancer and other extracolonic-associated malignancies. This disorder is inherited in an autosomal dominant pattern and is due to a mutation in one of the DNA mismatch repair genes. Although clinical and molecular understanding of the syndrome has progressed dramatically in the last decade, diagnosis of the syndrome is still a clinical challenge. This review summarizes the main features of the syndrome and provides an update of its management.
authors.affiliation: Department of Gastroenterology, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. mgiralde@clinic.ub.es
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Giráldez
authors.forename: Sergi
authors.initials: S
authors.lastname: Castellví-Bel
authors.forename: Francesc
authors.initials: F
authors.lastname: Balaguer
authors.forename: Victòria
authors.initials: V
authors.lastname: Gonzalo
authors.forename: Teresa
authors.initials: T
authors.lastname: Ocaña
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D053843:DNA Mismatch Repair; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D053842:Microsatellite Instability; D009154:Mutation