Prorenin in diabetes mellitus.
A rise in plasma prorenin often precedes the onset of vascular injury in patients with diabetes mellitus. Plasma prorenin measurements may be useful for predicting which patients will develop vascular injury and for monitoring the progression of the disease. A hypothesis is presented that accounts for these relationships and for the cosecretion of prorenin and renin into the circulation.
Halimi
J M
JM
Cardiovascular Center, Cornell University Medical College, New York, NY 10021, USA.
Sealey
J E
JE