title: Longitudinal analysis of pulmonary function in adults with sickle cell disease.
abstract: Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. jfield@im.wustl.edu
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Field
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Glassberg
authors.forename: Annette
authors.initials: A
authors.lastname: Gilmore
authors.forename: Joanna
authors.initials: J
authors.lastname: Howard
authors.forename: Sameer
authors.initials: S
authors.lastname: Patankar
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Sally C
authors.initials: SC
authors.lastname: Davies
authors.forename: Michael R
authors.initials: MR
authors.lastname: Debaun
authors.forename: Robert C
authors.initials: RC
authors.lastname: Strunk
mesh_terms: D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000502:physiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged