title: Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone Hapten.
abstract: We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo 6S 9- x I x nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH 3) 6] (3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg x mL (-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China.
authors.forename: Nijuan
authors.initials: N
authors.lastname: Sun
authors.forename: Martin
authors.initials: M
authors.lastname: McMullan
authors.forename: Pagona
authors.initials: P
authors.lastname: Papakonstantinou
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Dragan
authors.initials: D
authors.lastname: Mihailovic
authors.forename: Meixian
authors.initials: M
authors.lastname: Li
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry / Q000295:instrumentation*; D004970:Estrone / Q000032:analysis*; D006241:Haptens / Q000032:analysis*; D007454:Iodides / Q000737:chemistry*; D008982:Molybdenum / Q000737:chemistry*; D053770:Nanowires; D013056:Spectrophotometry, Ultraviolet; D013455:Sulfur / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
chemical_list: D006241:Haptens; D007454:Iodides; D004970:Estrone; D013455:Sulfur; D008982:Molybdenum