Modulation of IgA synthesis by neuroendocrine peptides.
Prolactin, estrogen, and progesterone together induce proliferation of the mammary glands with a coincident increase in the IgA-secreting plasma cells in the tissue. Of these three hormones, Prolactin is the most effective single peptide in stimulating IgA production. Vasoactive intestinal peptide (VIP) and somatostatin have also been shown to modulate IgA production. Although more extensive investigation is required, delineation of an immune axis involving prolactin, VIP, and somatostatin in mucosal immune tissue such as mammary gland is a promising area of research with clinical relevance to neonatal resistance to infection.
Hermann
G E
GE
Departments of Pediatrics and Medical Microbiology Immunology, Ohio State University, Columbus, OH 43205, USA.
Sue O'Dorisio
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