Investigations concerning the correlation of COX-1 inhibitory and hydroxyl radical scavenging activity.
The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.
Scholz
Michael
M
Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg-University, Mainz, Germany.
Ulbrich
Holger
H
Mattern
Andreas
A
Kramb
Jan-Peter
JP
Kiefer
Werner
W
Dannhardt
Gerd
G
D000818:Animals; D002417:Cattle; D051545:Cyclooxygenase 1 / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism*; D013329:Structure-Activity Relationship
D016861:Cyclooxygenase Inhibitors; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D051545:Cyclooxygenase 1