title: Current developments in the molecular genetics of the polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is most likely a complex trait with an oligogenic basis. In this article, we present evidence from molecular genetic studies for involvement of the steroid synthesis gene CYP11a (coding for P450 cholesterol side-chain cleavage) in the aetiology of hyperandrogenism. Variation in the regulatory region of the insulin gene also appears to contribute to the development of PCOS.
authors.affiliation: Department of Obstetrics and Gynaecology, Imperial College School of Medicine, St Mary's Hospital, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Franks
authors.forename: N
authors.initials: N
authors.lastname: Gharani
authors.forename: D
authors.initials: D
authors.lastname: Waterworth
authors.forename: S
authors.initials: S
authors.lastname: Batty
authors.forename: D
authors.initials: D
authors.lastname: White
authors.forename: R
authors.initials: R
authors.lastname: Williamson
authors.forename: M
authors.initials: M
authors.lastname: McCarthy