title: Successful control of an outbreak of invasive aspergillosis in a regional haematology unit during hospital construction works.
abstract: We report the successful control of an outbreak of six cases of nosocomial invasive aspergillosis (IA) in our haematology unit coinciding with major hospital construction works. Infection control changes included unit relocation, impermeable barriers at construction site, face-masking and voriconazole prophylaxis of 18 further high-risk patients, none of which developed breakthrough IA. A multi-faceted pre-emptive approach involving clinicians, hospital management, engineering and building departments is essential in preventing nosocomial IA outbreaks.
authors.affiliation: Department of Infectious Diseases, Geelong Hospital, Geelong, Victoria, Australia.
authors.forename: C C
authors.initials: CC
authors.lastname: Chang
authors.forename: A C
authors.initials: AC
authors.lastname: Cheng
authors.forename: B
authors.initials: B
authors.lastname: Devitt
authors.forename: A J
authors.initials: AJ
authors.lastname: Hughes
authors.forename: P
authors.initials: P
authors.lastname: Campbell
authors.forename: K
authors.initials: K
authors.lastname: Styles
authors.forename: J
authors.initials: J
authors.lastname: Low
authors.forename: E
authors.initials: E
authors.lastname: Athan
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000453:epidemiology / Q000517:prevention & control*; D018890:Chemoprevention; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control*; D004781:Environmental Exposure / Q000517:prevention & control; D006405:Hematology; D006749:Hospital Design and Construction; D006757:Hospital Units; D006801:Humans; D017053:Infection Control / Q000379:methods*; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole