title: Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells.
abstract: We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.
authors.affiliation: Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kohguchi@giib.or.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohguchi
authors.forename: Minako
authors.initials: M
authors.lastname: Koike
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Suwa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Koshimizu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mizutani
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
mesh_terms: D000434:Alcoholic Beverages / Q000032:analysis; D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D000521:alpha-MSH / Q000494:pharmacology
chemical_list: D005419:Flavonoids; D008543:Melanins; D010636:Phenols; D059808:Polyphenols; D000521:alpha-MSH; D014442:Monophenol Monooxygenase