title: Expression of myositis specific autoantigens during post-natal myogenesis.
abstract: Idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM) are a group of rare autoimmune diseases, characterized by an inflammatory infiltrate within the skeletal muscle and high titer of circulating autoantibodies in the patient's serum. The etiopathogenesis of these diseases is not known and the relationship between the specific muscle involvement and the ubiquitary presence of the targeted antigens is still unclear. The enhanced expression of myositis specific autoantigens in regenerating muscle fibers from biopsies of PM and DM patients compared to normal muscle has been recently demonstrated. In order to understand whether candidate autoantigens in myositis are expressed during post-natal myogenesis, we performed immunolocalization studies of myositis specific autoantigens in skeletal muscle from newborn and adult rats. Our observations indicate the presence of myositis specific autoantigens during post-natal myogenesis, with possible implications for the induction and/or amplification of the immune-inflammatory response, in patients affected with autoimmune myositis.
authors.affiliation: Laboratory of Translational Myology, Interdepartmental Research Institute of Myology, c/o Department of Biomedical Sciences, Padova, Italy. sanzamp@unipd.it
authors.forename: Sandra
authors.initials: S
authors.lastname: Zampieri
authors.forename: Donatella
authors.initials: D
authors.lastname: Biral
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Adami
authors.forename: Anna
authors.initials: A
authors.lastname: Ghirardello
authors.forename: M Elisa
authors.initials: ME
authors.lastname: Rampudda
authors.forename: Marta
authors.initials: M
authors.lastname: Tonello
authors.forename: Andrea
authors.initials: A
authors.lastname: Doria
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001324:Autoantigens / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism; D006643:Histidine-tRNA Ligase / Q000378:metabolism; D006801:Humans; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex; D009121:Muscle Denervation / Q000379:methods; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism; D009220:Myositis / Q000097:blood / Q000276:immunology*; D051381:Rats
chemical_list: D001324:Autoantigens; C115323:CHD4 protein, human; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex; D000251:Adenosine Triphosphatases; D004265:DNA Helicases; D018995:Myosin Heavy Chains; D006643:Histidine-tRNA Ligase