Management of patients with refractory migraine and PFO: Is MIST I relevant?
The results of the randomized clinical trial entitled: Migraine Intervention with Starflex Technology (MIST), produced surprising and disappointing results on the effect of PFO closure to decrease migraine headaches. There have been allegations of misrepresentation of the effectiveness of this device. These issues have significant implications in how randomized clinical trials are performed that will impact current and future planned trials of PFO closure to treat migraine headaches.
Tobis
Jonathan
J
UCLA-David Geffen School of Medicine, BL-394 CHS, 10833 LeConte Ave., Los Angeles, CA 90095-1717, USA.
D006328:Cardiac Catheterization / Q000295:instrumentation*; D016265:Conflict of Interest; D030881:Disclosure; D054092:Foramen Ovale, Patent / Q000150:complications / Q000601:surgery*; D006801:Humans; D020325:Migraine with Aura / Q000209:etiology / Q000517:prevention & control*; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D012107:Research Design