Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry.
In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components.
Hosoi
Shinzo
S
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, 882-8508, Japan. shosoi@phoenix.ac.jp
Shimizu
Eri
E
Arimori
Kazuhiko
K
Okumura
Manabu
M
Hidaka
Muneaki
M
Yamada
Mitsuko
M
Sakushima
Akiyo
A
D044946:Biflavonoids / Q000302:isolation & purification / Q000494:pharmacology; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology; D002853:Chromatography, Liquid; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D005638:Fruit; D006801:Humans; D066298:In Vitro Techniques; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D044945:Proanthocyanidins / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
D044946:Biflavonoids; D065607:Cytochrome P-450 Enzyme Inhibitors; D010936:Plant Extracts; D044945:Proanthocyanidins; C479579:procyanidin B1; C479580:procyanidin B2; D002392:Catechin; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A