The renin-angiotensin system in the pituitary gland.
There is evidence that angiotensin II, in addition to being generated in the circulating blood, is synthesized in the anterior pituitary lobe and other endocrine tissues. Angiotensin II produced locally may act on pituitary cell receptors to modulate or mediate the action of other hormonal factors. However, tissue angiotensins may be synthesized by a different mechanism than most other neuroendocrine peptides. A precise understanding of the mode of formation of local angiotensin II is necessary for the comprehension of its physiologic role in the pituitary gland.
Deschepper
C F
CF
Department of Physiology, University of California, San Francisco, CA 94143, USA.