title: Total synthesis of lobatoside E, a potent antitumor cyclic triterpene saponin.
abstract: Lobatoside E, a novel and complex cyclic triterpene saponin showing potent antitumor activities, has been synthesized for the first time, employing a highly modular approach. The synthesis, starting with oleanolic acid, D-glucose, D-galactose, L-arabinose, and L-rhamnose, requires a total of 73 steps, with the longest linear sequence of 31 steps and in 1.2% overall yield.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Zhu
authors.forename: Pingping
authors.initials: P
authors.lastname: Tang
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D019662:Cucurbitaceae / Q000737:chemistry; D006031:Glycosylation; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C529635:lobatoside E