title: Structure-antibacterial activity relationship for 9-O,9'-O-demethyl (+)-virgatusin.
abstract: The relationship between the antibacterial activity and structure of 9-O,9'-O-demethyl (+)-virgatusin (Virg 3) was examined. The conversion of hydroxy groups on the 9 and 9' positions to amino groups increased the activity. It was found that the 3'-methoxy group was more important for higher activity than the 4'-methoxy group on the 7'-phenyl group, and that the 3,4-methylenedioxy group on the 7-phenyl group was necessary for activity.
authors.affiliation: Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tago
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Maruyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Akiyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugahara
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Koba
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: C530420:9-O,9'-O-demethylvirgatusin; D000900:Anti-Bacterial Agents; D001688:Biological Products; D005663:Furans; D017705:Lignans; C511226:virgatusin