Electrokinetic probes for single-step screening of polyol stereoisomers: the virtues of ternary boronate ester complex formation.
Electrokinetic probes based on the differential migration of ternary boronate ester complexes permit the selective analysis of micromolar levels of UV-transparent polyol stereoisomers in urine samples via dynamic complexation-capillary electrophoresis that is applicable to single-step screening of in-born errors of sugar metabolism, such as galactosemia.
Kaiser
Claire
C
Department of Chemistry, McMaster University, Hamilton, ON, L8S 4M1, Canada.
Segui-Lines
Giselle
G
D'Amaral
Jason C
JC
Ptolemy
Adam S
AS
Britz-McKibbin
Philip
P
D001897:Boronic Acids / Q000737:chemistry*; D002021:Buffers; D004563:Electrochemistry; D019075:Electrophoresis, Capillary; D005693:Galactosemias / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D015335:Molecular Probes / Q000737:chemistry*; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013402:Sugar Alcohols / Q000652:urine*
D001897:Boronic Acids; D002021:Buffers; D015335:Molecular Probes; D013402:Sugar Alcohols; C017562:3-nitrobenzeneboronic acid