title: Lipid-lowering therapy is related to inflammatory markers and 3-year mortality in patients with critical limb ischemia.
abstract: To evaluate relationships between lipid-lowering therapy, inflammation, and 3-year mortality in critical limb ischemia (CLI), 259 consecutive CLI patients underwent evaluation of medication, tumor necrosis factor-alpha, interleukin-6 (IL-6), neopterin, high-sensitivity C-reactive protein (hs-CRP), 8-epi-PGF(2 alpha), and endothelin-1. Mortality was assessed after 3 years. Sixty-one patients (24%) were on lipid-lowering therapy and 59 patients (97%) on statins. Patients on lipid-lowering therapy were younger and showed lower low-density lipoprotein cholesterol, hs-CRP, and IL-6 levels than patients without therapy. Three-year survival was higher among patients on lipid-lowering therapy. In logistic regression, the effect of lipid-lowering therapy on 3-year survival was significant with inflammatory markers entered into the model one by one but disappeared when all inflammatory markers were entered into the model together. In conclusion, hs-CRP and IL-6 levels were lower and 3-year survival was higher in CLI patients on lipid-lowering therapy.
authors.affiliation: University of Lund, Department of Vascular Diseases, Malmö University Hospital, Malmö, Sweden. nazim.isma@skane.se
authors.forename: Nazim
authors.initials: N
authors.lastname: Isma
authors.forename: Jamal
authors.initials: J
authors.lastname: Barani
authors.forename: Ingrid
authors.initials: I
authors.lastname: Mattiasson
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindblad
authors.forename: Anders
authors.initials: A
authors.lastname: Gottsäter
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D007511:Ischemia / Q000097:blood / Q000401:mortality*; D016015:Logistic Models; D008297:Male; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein