title: Immunoprofile of kuttner tumor (chronic sclerosing sialadenitis).
abstract: In the present study, the immunoprofile of chronic sclerosing sialadenitis, also known as Kuttner tumor, was analyzed. Two cases that occurred in the submandibular gland of male patients were submitted to immunohistochemical reactions to different antibodies. Histological examinations showed a submandibular gland exhibiting various degrees of atrophy with destruction of acini, infiltration by inflammatory cells, and periductal fibrosis. Reactions to cytokeratins (CKs) showed acini and duct remnants positive to CKs 7, 8, 19, and 13. CK14 stained myoepithelial cells around preserved acini and intercalated duct, and also basal cell of excretory ducts, but was negative in proliferating and branching ducts. Smooth muscle actin (SMA) was expressed by myofibroblasts in periductal fibrosis, and an intense expression of extracellular components was also seen. Lymphocyte markers showed, besides mature follicles, a higher presence of CD45RO positive cells. Thus, the immunoprofile of Kuttner is much more in keeping with an inflammatory-induced degenerative disease than with a preneoplastic lesion.
authors.affiliation: Department of Oral Pathology, University of São Paulo, São Paulo, Brazil. scmsouza@usp.br
authors.forename: Suzana Orsini
authors.initials: SO
authors.lastname: Machado de Sousa
authors.forename: Kivia
authors.initials: K
authors.lastname: Linhares Ferrazzo
authors.forename: Adriano
authors.initials: A
authors.lastname: Mota Loyola
authors.forename: Jean Nunes
authors.initials: JN
authors.lastname: Dos Santos
authors.forename: Vera Cavalcanti
authors.initials: VC
authors.lastname: de Araújo
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism; D008297:Male; D012598:Sclerosis / Q000378:metabolism / Q000473:pathology; D012793:Sialadenitis / Q000378:metabolism* / Q000473:pathology; D013363:Submandibular Gland / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D007633:Keratins