title: Antifungal activity of coumarins.
abstract: The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 microg/ml for Fusarium solani and 250 micro/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.
authors.affiliation: Departamento de Microbiologia e Parasitologia, Centro de Ciências Biológicas da Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Montagner
authors.forename: Simone M
authors.initials: SM
authors.lastname: de Souza
authors.forename: Cláudia
authors.initials: C
authors.lastname: Groposoa
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
authors.forename: Elza F A
authors.initials: EF
authors.lastname: Smânia
authors.forename: Artur
authors.initials: A
authors.lastname: Smânia
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D003374:Coumarins