A general approach for sample size and power calculations based on the Haseman-Elston method.
Risch and Zhang (1995; Science 268: 1584-9) reported a simple sample size and power calculation approach for the Haseman-Elston method and based their computations on the null hypothesis of no genetic effect. We argue that the more reasonable null hypothesis is that of no recombination. For this null hypothesis, we provide a general approach for sample size and power calculations within the Haseman-Elston framework. We demonstrate the validity of our approach in a Monte-Carlo simulation study and illustrate the differences using data from published segregation analyses on body weight and heritability estimates on carotid artery artherosclerotic lesions.
Hädicke
Oliver
O
Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Ratzeburger Allee 160, Haus 4, 23538 Lübeck, Deutschland.
Pahlke
Friedrich
F
Ziegler
Andreas
A
D002339:Carotid Arteries; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009010:Monte Carlo Method; D019655:Quantitative Trait, Heritable; D018401:Sample Size