Serum adiponectin, C-reactive protein and TNF-alpha levels in obese Korean children.
To determine whether there are differences of serum adiponectin, CRP and TNF-a levels between obese and non-obese children and to investigate the relationship between childhood obesity and inflammation.



A total of 103 (73 obese, 30 non-obese) children were evaluated for height, weight, blood pressure and body mass index (BMI). We measured serum adiponectin, hs-CRP, and TNF-alpha levels and analyzed their correlation with BMI, serum glucose, lipid profile and insulin resistance.



Serum adiponectin levels were significantly decreased in the obese children compared to non-obese children, and had a negative correlation with BMI, fasting glucose and HOMA-IR. Serum hs-CRP and TNF-alpha levels were increased in obese children compared to non-obese children, and had a positive correlation with BMI.



Serum adiponectin level was decreased and serum CRP and TNF-alpha levels were increased in obese children. Our findings suggest that childhood obesity is associated with inflammatory processes.
Shin
Jung Yeon
JY
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
Kim
Soo Young
SY
Jeung
Min Jee
MJ
Eun
So Hee
SH
Woo
Chan Wook
CW
Yoon
Soo-Young
SY
Lee
Kee-Hyoung
KH
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D003920:Diabetes Mellitus / Q000209:etiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000208:ethnology / Q000209:etiology; D007723:Korea; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000208:ethnology; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D052242:Adiponectin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein