title: Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.
abstract: Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.
authors.affiliation: Midwestern University Chicago College of Pharmacy, Infectious Diseases Pharmacist, Northwestern Memorial Hospital, 251 E. Huron St., Feinberg Pavilion LC-700, Chicago, IL 60611, USA. mscheetz@nmh.org
authors.forename: Marc H
authors.initials: MH
authors.lastname: Scheetz
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Knechtel
authors.forename: Michael
authors.initials: M
authors.lastname: Malczynski
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Postelnick
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015994:Incidence; D000069349:Linezolid; D017720:Molecular Epidemiology; D009154:Mutation; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid