title: [Primary central nervous system lymphoma--a single center experience].
abstract: Primary lymphoma of central nervous system (PCNSL) represents a distinct form of extranodal non-Hodgkin's lymphoma localized to central nervous system. We collected data retrospectively of 20 patients with PCNSL treated at Division of Hematology of UHC Zagreb in the last eight years. A total of 13 patients received high dose methotrexate (4 g/m2) while others received other chemotherapy regimens or radiotherapy only. Complete remission rate was 40% and estimated 2-years actuarial survival was 30%. There were no treatment related deaths or significant severe adverse events. Our results are satisfactory in patients younger than 60 years, especially if treated with high dose methotrexate. Older patients, who represent majority of the patients, have dismal prognosis irrespective of treatment modality.
authors.affiliation: Zavod za hematologiju, Klinika za unutarnje bolesti Medicinskog fakulteta, KBC Zagreb..
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Mitrović
authors.forename: Ivo
authors.initials: I
authors.lastname: Radman
authors.forename: Igor
authors.initials: I
authors.lastname: Aurer
authors.forename: Duska
authors.initials: D
authors.lastname: Petranović
authors.forename: Fedor
authors.initials: F
authors.lastname: Santek
authors.forename: Boris
authors.initials: B
authors.lastname: Labar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged