title: Detection of the Klebsiella pneumoniae carbapenemase type 2 Carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid.
abstract: The Klebsiella pneumoniae carbapenemase (KPC) was detected in carbapenem-resistant isolates of Citrobacter freundii and Klebsiella oxytoca recovered from different patients in a Michigan hospital. Restriction analysis and hybridization with a KPC-specific probe showed the bla(KPC-2) genes of these two genera of the family Enterobacteriaceae are carried on a common plasmid.
authors.affiliation: Division of Healthcare Quality Promotion, National Center for the Prevention, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. jkr1@cdc.gov
authors.forename: J Kamile
authors.initials: JK
authors.lastname: Rasheed
authors.forename: James W
authors.initials: JW
authors.lastname: Biddle
authors.forename: Karen F
authors.initials: KF
authors.lastname: Anderson
authors.forename: Laraine
authors.initials: L
authors.lastname: Washer
authors.forename: Carol
authors.initials: C
authors.lastname: Chenoweth
authors.forename: John
authors.initials: J
authors.lastname: Perrin
authors.forename: Duane W
authors.initials: DW
authors.lastname: Newton
authors.forename: Jean B
authors.initials: JB
authors.lastname: Patel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000378:metabolism* / Q000494:pharmacology; D016971:Citrobacter freundii / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D009693:Nucleic Acid Hybridization / Q000379:methods; D010957:Plasmids / Q000235:genetics*; D015183:Restriction Mapping; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases