title: Dynamics of LPO products and oxidative modification of proteins in human brain during postnatal development.
abstract: Opposite changes in the content of LPO products and products of oxidative modification of proteins were detected in human brain structures in the course of postnatal development. A clear-cut ontogenetic reduction of LPO products was observed in field 17 of the cortex, archicortex structures, and in the hypothalamus. Age-specific increase in the levels of products of oxidative modification of proteins was recorded in all compartments of the brain; it peaked by the age of 12-21 years and was most pronounced (4-6-fold) in the visual cortex, hippocampus, diencephalic and pontobulbar compartments of the brain.
authors.affiliation: Chelyabinsk State Medical Academy. volcheg@yandex.ru
authors.forename: I A
authors.initials: IA
authors.lastname: Volchegorskii
authors.forename: N V
authors.initials: NV
authors.lastname: Malinovskaya
authors.forename: O V
authors.initials: OV
authors.lastname: Shumelyova
authors.forename: S E
authors.initials: SE
authors.lastname: Shiemyakov
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D008297:Male; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D014018:Tissue Distribution
chemical_list: D009419:Nerve Tissue Proteins