Role of heat shock proteins HSP70 and HSP32 in the protective effect of adaptation of cultured HT22 hippocampal cells to oxidative stress.
Preadaptation of cultured HT22 mouse hippocampal neurons to oxidative stress prevented cell damage induced by severe oxidative stress. This protection manifested in a decrease in metabolic disturbances in neurons. Adaptation of neurons to oxidative stress was accompanied by accumulation of HSP32 and HSP70. HSP synthesis inhibitor quercetin abolished the protective effect of adaptation under conditions of oxidative stress. Activation of HSP70 synthesis in neurons is an important mechanism for adaptive protection of cells.
Khomenko
I P
IP
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. i_khomenko@mail.ru
Bakhtina
L Yu
LY
Zelenina
O M
OM
Kruglov
S V
SV
Manukhina
E B
EB
Bayda
L A
LA
Malyshev
I Yu
IY
D000222:Adaptation, Physiological; D000818:Animals; D002460:Cell Line; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000633:toxicity; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress
D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D006861:Hydrogen Peroxide