Adsorption of insulin onto infusion sets used in adult intensive care unit and neonatal care settings.
BACKGROUND
Insulin adsorption onto infusion equipment may affect glycaemic control.


METHODS
The change in insulin concentration during delivery through tubing employed for adult ICU and neonatal patients was determined using continuous flow UV analysis.


RESULTS
Insulin adsorption depended on tubing composition, dimensions and flow rate, being highest for neonatal polyvinylchloride tubing at low flow rates.


CONCLUSIONS
In continuous insulin therapy, we should consider the nature of the infusion set and flow rate.
Zahid
Najam
N
Department of Pharmaceutics, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Taylor
Kevin M G
KM
Gill
Hardyal
H
Maguire
Fiona
F
Shulman
Rob
R
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use*; D061389:Insulin, Regular, Pork; D007362:Intensive Care Units; D007363:Intensive Care Units, Neonatal
D001786:Blood Glucose; D007328:Insulin; D061389:Insulin, Regular, Pork; C000006:insulin, neutral