title: Effector memory alphabeta T lymphocytes can express FcgammaRIIIa and mediate antibody-dependent cellular cytotoxicity.
abstract: Human memory T cells are comprised of distinct populations with different homing potential and effector functions: central memory T cells that mount recall responses to Ags in secondary lymphoid organs, and effector memory T cells that confer immediate protection in peripheral tissues. In the present study we demonstrate that a proportion of effector memory T cells express FcgammaRIIIa (CD16), are perforin positive, and directly mediate Ab-dependent cytotoxicity ex vivo. This particular alphabeta T lymphocyte subset has the morphology of large granular lymphocytes, increases proportionately in vivo during reactive lymphocytosis, and can be detected in vitro among EBV-specific T lymphocytes after stimulation with EBV Ags. Consequently, during a normal immune response, amplification of these effector memory T lymphocytes that are capable of Ab-dependent cytotoxicity may have beneficial or harmful consequences depending on the presence of pathogen- or tissue-specific Abs, respectively.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 601, Nantes, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Clémenceau
authors.forename: Régine
authors.initials: R
authors.lastname: Vivien
authors.forename: Mathilde
authors.initials: M
authors.lastname: Berthomé
authors.forename: Nelly
authors.initials: N
authors.lastname: Robillard
authors.forename: Richard
authors.initials: R
authors.lastname: Garand
authors.forename: Géraldine
authors.initials: G
authors.lastname: Gallot
authors.forename: Solène
authors.initials: S
authors.lastname: Vollant
authors.forename: Henri
authors.initials: H
authors.lastname: Vié
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D002460:Cell Line; D002478:Cells, Cultured; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology* / Q000378:metabolism; D017452:Receptors, IgG / Q000276:immunology / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*
chemical_list: C496124:FCGR3A protein, human; D016693:Receptors, Antigen, T-Cell, alpha-beta; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha