title: Retrovirus vectors.
abstract: In this chapter, we present an outline of retroviruses and retroviral vectors - the concepts and applications. In particular, we discuss lentiviral vectors and the suitability of these vectors for the treatment of renal pathologies. We review vector design and the data on the use of lentiviral vectors for gene transfer to the kidney. Finally, we discuss potential pathologies and avenues for the optimization of the technology for gene transfer to a complex organ such as the kidney.
authors.affiliation: Department of Genetics Cell Biology and Development, Institute of Human Genetics, Beckman Center for Transposon Research and the Institute of Molecular Virology, University of Minnesota, Minneapolis, Minn., USA.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Lech
authors.forename: Nikunj V
authors.initials: NV
authors.lastname: Somia
mesh_terms: D017101:Bacteriophage P1 / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D019426:Integrases / Q000235:genetics; D007674:Kidney Diseases / Q000628:therapy*; D016086:Lentivirus / Q000235:genetics / Q000254:growth & development; D011533:Proviruses / Q000235:genetics / Q000254:growth & development; D011991:Receptors, Virus / Q000502:physiology; D012190:Retroviridae / Q000235:genetics* / Q000254:growth & development
chemical_list: D011991:Receptors, Virus; C045073:Cre recombinase; D019426:Integrases