Microarray gene expression profiling in meningiomas and schwannomas.
Microarray gene expression profiling is a high throughput system recently used in basic and applied research. It provides a large amount of data -at molecular level- that once acquired, must be functionally integrated in order to find common patterns within a defined group of biological samples. In addition to identification of differentially expressed genes and the establishment of gene regulation patterns, microarrays may also allow us to discover new tumor markers that could have a great impact on the improvement of clinical practice and therapeutics for cancer. The classification method used for cancer is currently based on the morphological characteristics of the biological samples. The information obtained with this method is limited, omitting many important tumor characteristics like the proliferation rate, the capacity of invasion and metastases, as well as the possible development of mechanisms of cellular resistance to treatment. Microarrays can be used in combination with conventional diagnostics as a helpful complement. In this review we focus on how this technology has contributed to our knowledge of the molecular pathogenesis of meningiomas and schwannomas, its potential role as a useful tool for tumor classification and its application in clinical practice.
Martinez-Glez
V
V
Unidad de Investigación, Hospital Universitario La Paz, Madrid, Spain. vmartinezg.hulp@salud.madrid.org
Franco-Hernandez
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C
Rey
J A
JA
D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D008579:Meningioma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D009442:Neurilemmoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis