Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study.
Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.
Khaleeli
Zhaleh
Z
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom.
Ciccarelli
Olga
O
Manfredonia
Francesco
F
Barkhof
Frederik
F
Brochet
Bruno
B
Cercignani
Mara
M
Dousset
Vincent
V
Filippi
Massimo
M
Montalban
Xavier
X
Polman
Chris
C
Rovaris
Marco
M
Rovira
Alex
A
Sastre-Garriga
Jaume
J
Vellinga
Machteld
M
Miller
David
D
Thompson
Alan
A
D000328:Adult; D000368:Aged; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D017678:Sex Distribution; D013116:Spinal Cord / Q000473:pathology* / Q000503:physiopathology; D013997:Time Factors