title: Clinical symptoms and histopathological findings in subjects with adenomyosis uteri.
abstract: OBJECTIVE
  The purpose of this study was to compare the clinical symptoms and histopathological findings in subjects with adenomyosis uteri.
  
  
  METHODS
  Infiltration depth and spread of adenomyotic foci together with clinical symptoms and findings were compared in a total of 103 subjects who had undergone hysterectomy and were diagnosed with adenomyosis uteri through histopathological examinations.
  
  
  RESULTS
  The spread of adenomyotic foci in myometrial tissues was observed to significantly increase as the depth of myometrial infiltration increased in subjects with adenomyosis (p < 0.05). It was observed that there was significantly higher myometrial infiltration depth in subjects with dysmenorrhea and severe anemia, and diffuse adenomyotic foci in subjects with menometrorrhagia (p < 0.05).
  
  
  CONCLUSIONS
  Increased infiltration depth and spread of adenomyotic foci in myometrial tissues in subjects with adenomyosis uteri were studied. When clinical symptoms and findings in subjects with adenomyosis, such as dysmenorrhea, anemia and menometrorrhagia are compared with these histopathological findings, infiltration depth and spread of adenomyotic foci appear to determine the clinical severity of adenomyosis.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey. cirpanteksin@yahoo.com
authors.forename: T
authors.initials: T
authors.lastname: Cirpan
authors.forename: O
authors.initials: O
authors.lastname: Yeniel
authors.forename: M
authors.initials: M
authors.lastname: Ulukus
authors.forename: A
authors.initials: A
authors.lastname: Ozbal
authors.forename: G
authors.initials: G
authors.lastname: Gundem
authors.forename: S
authors.initials: S
authors.lastname: Ozsener
authors.forename: I
authors.initials: I
authors.lastname: Mete Itil
authors.forename: O
authors.initials: O
authors.lastname: Zekioglu
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004715:Endometriosis / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology*