title: Clinical significance of high-density lipoprotein cholesterol in left-sided infective endocarditis.
abstract: Decreased serum levels of high-density lipoprotein (HDL) cholesterol have been shown to be of prognostic significance in patients with severe infectious diseases. Serum HDL cholesterol levels were therefore investigated as a possible parameter for the prediction of clinical outcomes in patients with left-sided infective endocarditis (IE). Fifty-four patients with IE with available admission serum HDL cholesterol levels were included in the study. A clinical outcome was defined as a complicated course during hospitalization. Forty-two patients had complicated courses during their in-hospital stays. The median serum HDL cholesterol level was significantly lower in patients with IE (n = 54) than healthy controls (n = 26) (26 vs 47 mg/dl, p <0.0001). In the 42 patients with complicated courses, the median serum HDL cholesterol level was lower compared with that in 12 patients with uneventful courses (24 vs 36 mg/dl, p = 0.011). A cut point of serum HDL cholesterol level of 25 mg/dl had sensitivity of 62%, specificity of 75%, and a positive predictive value of 90% for predicting clinical outcomes. In conclusion, serum HDL cholesterol levels measured at admission were markedly reduced in patients with left-sided IE. Furthermore, low serum HDL cholesterol levels predicted complicated clinical courses in these patients.
authors.affiliation: Department of Cardiology, Rize State Hospital, Rize, Turkey. drmarist@yahoo.co.uk
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kahveci
authors.forename: Fatih
authors.initials: F
authors.lastname: Bayrak
authors.forename: Bulent
authors.initials: B
authors.lastname: Mutlu
authors.forename: Yusuf Emre
authors.initials: YE
authors.lastname: Gurel
authors.forename: Tansu
authors.initials: T
authors.lastname: Karaahmet
authors.forename: Kursat
authors.initials: K
authors.lastname: Tigen
authors.forename: Yelda
authors.initials: Y
authors.lastname: Basaran
mesh_terms: D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D004696:Endocarditis / Q000097:blood* / Q000150:complications* / Q000401:mortality; D005260:Female; D006760:Hospitalization; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D003404:Creatinine