Factors influencing EPA+DHA levels in red blood cells in Japan.
The blood eicosapentaenoic and docosahexaenoic acid (EPA+DHA) concentration is an important inverse risk factor for sudden cardiac death. However, it is not known what kinds of factors influence the EPA+DHA levels in the total phospholipid fraction in red blood cells (RBC EPA+DHA) in Japan, who regularly eat more fish with increasing age. Four hundred and fifty-six healthy individuals (320 men and 136 women, 18 to 70 years old) were recruited between 2002 and 2005. RBC EPA+DHA were measured by gas chromatography and questionnaires were administered. Multivariate analysis indicated that there were significant correlations between RBC EPA+DHA and (i) dietary EPA+DHA (beta=0.31), (ii) age (beta=0.33), (iii) gender (beta=-0.15) and (iv) physical activity (beta=-0.11) but not with body mass index or smoking.
Itomura
Miho
M
Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Fujioka
Shuntaro
S
Hamazaki
Kei
K
Kobayashi
Kouji
K
Nagasawa
Tetsuro
T
Sawazaki
Shigeki
S
Kirihara
Yuko
Y
Hamazaki
Tomohito
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002849:Chromatography, Gas; D004032:Diet; D004281:Docosahexaenoic Acids / Q000032:analysis / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000032:analysis / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D012737:Sex Factors
D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid