title: Psychiatric disturbances in CADASIL: a brief review.
abstract: BACKGROUND
  Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebrovascular disease, clinically characterized by a variable combination of migraine, recurrent transient ischemic attack (TIA) or lacunar strokes, cognitive decline, and mood disturbances. However, the assessment of psychiatric disturbances in this disease has never been carried out systematically.
  
  
  METHODS
  This paper presents a brief review of the literature regarding the occurrence of psychiatric disorders in CADASIL patients.
  
  
  RESULTS
  The prevalence of psychiatric disorders in CADASIL patients is reported to range from 20% to 41%. The psychiatric disturbances reported with the highest frequency are mood disturbances (9-41%). Pooling together the studies and considering a total of 454 CADASIL patients reported in the literature, 106 of these were affected by mood disturbances (24%). The majority of studies however did not use any defined criteria to assess the presence of psychiatric disorders and diagnoses were mainly based on history or review of clinical records.
  
  
  CONCLUSIONS
  The review of CADASIL literature suggests the need for a more structured approach to the investigation of these disturbances that are highly prevalent and may greatly impact quality of life in these patients.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Valenti
authors.forename: A
authors.initials: A
authors.lastname: Poggesi
authors.forename: F
authors.initials: F
authors.lastname: Pescini
authors.forename: D
authors.initials: D
authors.lastname: Inzitari
authors.forename: L
authors.initials: L
authors.lastname: Pantoni
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D046589:CADASIL / Q000453:epidemiology* / Q000503:physiopathology* / Q000523:psychology; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019964:Mood Disorders / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D019965:Neurocognitive Disorders / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology*; D015995:Prevalence