[Monitoring of anticoagulant treatment in patients with cancer].
Venous thromboembolic events are frequent in patients with cancer. Patients on anticoagulant therapy are both at increased risk for subsequent thromboembolic and bleeding events. Whatever the therapeutic option (vitamin K antagonists [VKA] or low-molecular-weight heparin [LMWH]) a clinic and biological monitoring is required. International Normalized Ratio (INR) variability is increased in patients with cancer as compared with patients without cancer and should be maintained in the target range. Anti-Xa activity measurement may be used in LMWH treatments, in order to detect a possible accumulation in any patients; platelet count monitoring is recommended. Interpretation is most often difficult because of numerous possible causes of thrombopenia in the patient with cancer. Anticoagulant clinics are developed in order to help practitioners and participate in the monitoring of anticoagulant treatments in those patients.
Mahé
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I
Médecine interne, hôpital Louis-Mourier, AP-HP, 178, rue des renouillers, 92700 Colombes, France. isabelle.mahe@lmr.aphp.fr <isabelle.mahe@lmr.aphp.fr>
Bosquet
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A
Medjkane
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A
Bal dit Sollier
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C
Drouet
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L
D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D004361:Drug Tolerance; D006470:Hemorrhage / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D019934:International Normalized Ratio; D008991:Monitoring, Physiologic / Q000379:methods; D009369:Neoplasms / Q000150:complications*; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000517:prevention & control*
D000925:Anticoagulants