title: Characterization of swine adiponectin and adiponectin receptor polymorphisms and their association with reproductive traits.
abstract: In this study, polymorphisms in genes encoding porcine adiponectin (ADIPOQ) and its receptors (ADIPOR1 and ADIPOR2) were evaluated for associations with reproductive traits in a Landrace sow population. Sixteen SNPs were identified, and among these, associations were found between reproductive traits and five SNPs. Heterozygous multiparous females for SNP ADIPOQEF601160:c.178G>A had fewer stillborn piglets (P < 0.05) and shorter weaning-to-oestrus intervals (P < 0.05). Multiparous females bearing the mutant allele for SNP ADIPOQEF601160:c.*1094_1095insC gave birth to fewer stillborn piglets (P < 0.05). In addition, selection for the ADIPOQ [A;C] haplotype is expected to result in multiparous sows having the lowest number of stillborn piglets and shorter weaning-to-oestrus intervals. In second-parity sows, the polymorphism in ADIPOR1 (AY856513:c.*129A>C) showed significant associations with live-born (P < 0.01) and stillborn (P < 0.05) piglets. In multiparous sows, a significant association was observed for an ADIPOR2 polymorphism (AY856514:c.*112G>A), with the c.*112GA genotype associated with shorter weaning-to-oestrus intervals (P < 0.01). Haplotype analyses of ADIPOR2 SNPs revealed that selection in favour of the [A;C] haplotype and against the [G;G] haplotype may result in sows having an increased number of live-born piglets and shorter weaning-to-oestrus intervals. We have therefore described specific SNPs and haplotypes that are associated with large litter size, fewer stillborn and mummified piglets and shorter weaning-to-oestrus intervals. Selection for these SNPs and haplotypes is a strategy to improve reproductive success in pigs.
authors.affiliation: Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC, Canada.
authors.forename: A A
authors.initials: AA
authors.lastname: Houde
authors.forename: B D
authors.initials: BD
authors.lastname: Murphy
authors.forename: O
authors.initials: O
authors.lastname: Mathieu
authors.forename: V
authors.initials: V
authors.lastname: Bordignon
authors.forename: M F
authors.initials: MF
authors.lastname: Palin
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004971:Estrus / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D008098:Litter Size / Q000235:genetics; D050498:Live Birth / Q000235:genetics / Q000662:veterinary; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D054419:Receptors, Adiponectin / Q000235:genetics*; D012098:Reproduction / Q000235:genetics*; D050497:Stillbirth / Q000235:genetics / Q000662:veterinary; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D052242:Adiponectin; D054419:Receptors, Adiponectin