Spinophilin and the immune synapse.
Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J. Unternaehrer, A. Jiang, J.-S. Shin, L. Delamarre, P. Allen, and I. Mellman. 2008. J. Cell Biol. 181:203-211) have captured a remarkable polarization of the cellular architecture of dendritic cells presenting an antigen to T cells.
Seed
Brian
B
Department of Pediatrics, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. bseed@ccib.mgh.harvard.edu
Xavier
Ramnik
R
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003712:Dendrites / Q000276:immunology; D006801:Humans; D008840:Microfilament Proteins / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology*; D013569:Synapses / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D000099273:Neurabins
D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D000099273:Neurabins