title: Toxic Effects in Siganus oramin by dietary exposure to 4-tert-octylphenol.
abstract: The integrated toxicities of 4-tert-octylphenol (t-OP) on Siganus oramin were investigated by dietary administration at doses of 5, 25 and 125 mg/kg body weight over 28 days. Significant increase was observed in the activity of hepatic glutathione S-transferase at 125 mg/kg on both day 14 and 28 in males, and at all doses on day 28 in females, and in hepatosomatic index at 25 mg/kg on day 14 in both sexes. Plasma levels of testosterone and cortisol decreased significantly at all doses on day 28. Histopathologic changes in liver, spleen, intestine and testis deteriorated with increasing doses and duration. The results suggest that S. oramin is sensitive to t-OP, and the above endpoints may be potential biomarkers for evaluating toxicities of environmental pollutants such as t-OP.
authors.affiliation: Marine Biology Institute of Shantou University, Shantou 515063, China.
authors.forename: Y B
authors.initials: YB
authors.lastname: Du
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhen
authors.forename: C B
authors.initials: CB
authors.lastname: Hu
authors.forename: W H
authors.initials: WH
authors.lastname: Liu
authors.forename: W Z
authors.initials: WZ
authors.lastname: Chen
authors.forename: Z W
authors.initials: ZW
authors.lastname: Sun
mesh_terms: D000821:Animal Feed; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D010473:Perciformes; D010636:Phenols / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013501:Surface-Active Agents / Q000633:toxicity*; D013737:Testis / Q000187:drug effects / Q000473:pathology; D013739:Testosterone / Q000097:blood; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D010636:Phenols; D013501:Surface-Active Agents; D014874:Water Pollutants, Chemical; D013739:Testosterone; D005982:Glutathione Transferase; C105260:4-tert-octylphenol; D006854:Hydrocortisone