Intrauterine insemination with double ejaculate compared with single ejaculate in male factor infertility: a pilot study.
The aim of this study was to compare the efficiency of using a double ejaculate with the efficiency of using a single ejaculate for intrauterine insemination in male subfertility. Eligibility for the study was a total motile sperm count between 1 x 10(6) and 5 x 10(6) on postwash sperm analysis. Thirty-nine couples were randomized to the study group, while another 50 couples were randomized to serve as the control group. Males in the study group were asked to produce a second semen sample within 2 hours of the first sample on the day of insemination. In the study group, the mean total motile sperm count in the first sample was 3.83 x 10(6) (SD +/- 0.85 x 10(6); range 1.1-4.9) and 3.99 x 10(6) (SD +/- 0.72 x 10(6); range 0.9-4.4) in the control group. The mean total motile sperm count in the second sample was 3.52 x 10(6) (SD +/- 1.46 x 10(6); range 0.9-3.7) in the study group. The mean total motile sperm count in the final inseminate was 7.35 x 10(6) (SD +/- 1.90 x 10(6); range 2.9-10.6) in the study group. The difference in total motile sperm counts between the study and the control group was statistically significant (P < .001). There were 6 pregnancies in the study group, providing a pregnancy rate of 15.3%, whereas there were 5 pregnancies in the control group, representing a pregnancy rate of 10% (P = .44). We concluded that although it does not increase the pregnancy rate significantly, obtaining a second semen sample when the motile sperm yield of the first semen sample is 1 million to 5 million significantly increases the total motile sperm count in the final inseminate.
Küçük
Tansu
T
GATA School of Medicine, Department of Obstetrics and Gynecology, 06018, Etlik, Ankara, Turkey. tansukucuk@gmail.com
Sozen
Eran
E
Buluc
Burcu
B
D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D013076:Sperm Count