title: Longitudinal association of body mass index with lung function: the CARDIA study.
abstract: BACKGROUND
  Lung function at the end of life depends on its peak and subsequent decline. Because obesity is epidemic in young adulthood, we quantified age-related changes in lung function relative to body mass index (BMI).
  
  
  METHODS
  The Coronary Artery Risk Development in Young Adults (CARDIA) study in 1985-86 (year 0) recruited 5,115 black and white men and women, aged 18-30. Spirometry testing was conducted at years 0, 2, 5 and 10. We estimated 10 year change in FVC, FEV1 and FEV1/FVC according to baseline BMI and change in BMI within birth cohorts with initial average ages 20, 24, and 28 years, controlling for race, sex, smoking, asthma, physical activity, and alcohol consumption.
  
  
  RESULTS
  Participants with baseline BMI < 21.3 kg/m2 experienced 10 year increases of 71 ml in FVC and 60 ml in FEV1 and neither measure declined through age 38. In contrast, participants with baseline BMI > or = 26.4 kg/m2 experienced 10 year decreases of 185 ml in FVC and 64 ml in FEV1. FEV1/FVC increased with increasing BMI. Weight gain was also associated with lung function. Those who gained the most weight over 10 years had the largest decrease in FVC, but FVC increased with weight gain in those initially thinnest. In contrast, FEV1 decreased with increasing weight gain in all participants, with maximum decline in obese individuals who gained the most weight during the study.
  
  
  CONCLUSIONS
  Among healthy young adults, increasing BMI in the initially thin participants was associated with increasing then stable lung function through age 38, but there were substantial lung function losses with higher and increasing fatness. These results suggest that the obesity epidemic threatens the lung health of the general population.
authors.affiliation: Dept of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA. Thya003@umn.edu
authors.forename: Bharat
authors.initials: B
authors.lastname: Thyagarajan
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: George G
authors.initials: GG
authors.lastname: Apostol
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Smith
authors.forename: Robert L
authors.initials: RL
authors.lastname: Jensen
authors.forename: Robert O
authors.initials: RO
authors.lastname: Crapo
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.forename: Cora E
authors.initials: CE
authors.lastname: Lewis
authors.forename: O Dale
authors.initials: OD
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D012129:Respiratory Function Tests / Q000706:statistics & numerical data*; D013223:Statistics as Topic; D014481:United States / Q000453:epidemiology