title: [Pathophysiology of the obesity hypoventilation syndrome].
abstract: The obesity hypoventilation syndrome (OHS) is defined by extreme overweight (BMI 30 kg/m2), daytime hypoventilation (PaCO2 > 45 mm Hg, the absence of other known causes of hypoventilation) and sleep-related breathing disorders. Obesity impairs breathing due to a restrictive ventilatory disorder, reduction of the capacity of respiratory muscles and diminishment of the ventilatory response. The restriction cannot serve as the only explanation of OHS because body weight or compliance on the one hand and hypoventilation on the other hand only correlate weakly. Obesity increases the work of breathing by greater body mass with its increased oxygen demand, impaired diaphragmatic mobility, upper airway obstruction, and oxygen desaturation which result in an inadequacy of oxygen demand and supply. The adjustment of the chemoreceptors can avoid the overload on the capacity of the respiratory muscles, at least in a number of patients or in the course of the disease. This disproportion results in hypercapnia. Furthermore, the level of leptin is an important factor in the pathophysiology of OHS. The blood level of leptin correlates with the body fat mass in humans. However, there seems to be a relative leptin deficiency in the brain in overweight humans. Therefore, in contrast to animals, leptin cannot sufficiently increase ventilation in man to avoid hypercapnia.
authors.affiliation: Institut für Pneumologie an der Universität Witten/Herdecke, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf- und Beatmungsmedizin, Krankenhaus Bethanien. randerath@klinik-bethanien.de
authors.forename: W J
authors.initials: WJ
authors.lastname: Randerath
authors.forename: S
authors.initials: S
authors.lastname: Stieglitz
authors.forename: W
authors.initials: W
authors.lastname: Galetke
authors.forename: C
authors.initials: C
authors.lastname: Laumanns
authors.forename: H-W
authors.initials: HW
authors.lastname: Duchna
authors.forename: T
authors.initials: T
authors.lastname: Schäfer
mesh_terms: D006801:Humans; D010845:Obesity Hypoventilation Syndrome / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy