Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog.
Canine anal sac gland carcinoma (ASGC) is a frequently described neoplasm that is highly aggressive and can frequently lead to metastatic spread. In this paper, we describe the successful treatment of an incompletely excised ASGC by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog received two courses of electrochemotherapy 14 days apart. Neither systemic nor local toxicities were detected during the whole course of therapy. The dog is still in complete remission after 18 months. Electrochemotherapy is a safe and efficacious adjuvant therapy for ASGC and warrants further investigation in order to standardize its protocols.
Spugnini
Enrico P
EP
S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy. info@enricospugnini.net
Dotsinsky
Ivan
I
Mudrov
Nikolay
N
Bufalini
Massimiliano
M
Giannini
Giovanni
G
Citro
Gennaro
G
Feroce
Florinda
F
Baldi
Alfonso
A
D000694:Anal Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000695:Anal Sacs / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D053672:Electrochemotherapy; D008297:Male; D012074:Remission Induction
D000970:Antineoplastic Agents; D002945:Cisplatin