Collaborative engineering: 3-D optical imaging and gas exchange simulation of in-vitro alveolar constructs.
This paper reports on the computational simulation and modeling of an in vitro alveolar construct system along the optical coherence microscopy (OCM) methods for visualizing engineered tissue. The optical imaging methods will be compared to immunohistochemical light microscopy samples of engineered alveolar constructs. Results show depth images of the alveolar tissue construct for a bilayer construct, as well as predictions of the gas exchange process in a simple model of a bio-reactor hosting the construct.
Rolland
Jannick P
JP
CREOL, College of Optics and Photonics, University of Central Florida, Orlando, FL 32816, USA.
Lee
Kye-Sung
KS
Mahmood
Ayesha
A
Fluck
Lisa
L
Duarte
Jaime
J
Kaya
Ilhan
I
Santhanam
Anand
A
Meemon
Panomsak
P
Murali
Supraja
S
Ilegbusi
Olusegun
O
Kupelian
Patrick
P
Warren
William L
WL
Molnar
Peter
P
Hickman
James
J
Kolattukudy
Papachan
P
D003198:Computer Simulation; D003299:Cooperative Behavior; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008853:Microscopy; D011659:Pulmonary Gas Exchange; D023822:Tissue Engineering; D041623:Tomography, Optical Coherence; D014481:United States