title: Safety of a fifth dose of diphtheria and tetanus toxoid and acellular pertussis vaccine in children experiencing extensive, local reactions to the fourth dose.
abstract: Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.
authors.affiliation: Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Margaret B
authors.initials: MB
authors.lastname: Rennels
authors.forename: Steven
authors.initials: S
authors.lastname: Black
authors.forename: Emily Jane
authors.initials: EJ
authors.lastname: Woo
authors.forename: Scott
authors.initials: S
authors.lastname: Campbell
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
mesh_terms: D001132:Arm / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects*; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines