title: Bioactive cyclobutane-containing alkaloids.
abstract: The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species. More than 210 compounds have been confirmed to show antimicrobial, antibacterial, anticancer, and other activities. Structures, origins, biosynthesis, photodimerization, and biological activities of a selection of cyclobutane-containing alkaloids and selected synthetic analogs of natural alkaloids are reviewed.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem, 91120, Israel. dvalery@cc.huji.ac.il
authors.forename: Valery M
authors.initials: VM
authors.lastname: Dembitsky
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D056890:Eukaryota / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D028321:Plant Preparations / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D003503:Cyclobutanes; D028321:Plant Preparations