[Antithrombotic therapy in operations on extracranial arteries].
Application of Clopidogrel in the postoperative period in patients after surgery on extracranial arteries was analyzed. The preparation was used in 56 patients. Uninterrupted intake of the drug took place during 5 to 12 months, 7+/-1.6 months on average. Stomach and duodenal ulcer was diagnosed in 11 patients (20%), 3 patients (5%) had chronic pancreatitis with periodical exacerbations and 2 patients (4%) had erythrocytemia. One bleeding requiring revision of the wound took place in the nearest postoperative period. During the whole period of observation there were no thrombotic or thromboembolic complication against the background of using plavix. In none of the patients granulocytopenia was revealed with continuous intake of plavix. An ultrasonic investigation of the operated arteries in the remote postoperative period failed to reveal hemodynamically significant restenoses of carotid arteries.
Sokurenko
G Iu
GIu
Luk'ianov
Iu V
IuV
Parusova
E V
EV
Edovina
L N
LN
D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D000077144:Clopidogrel; D003131:Combined Modality Therapy; D016894:Endarterectomy, Carotid / Q000379:methods*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012426:Russia / Q000453:epidemiology; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D005343:Fibrinolytic Agents; D000077144:Clopidogrel; D013988:Ticlopidine