title: Clinical evaluation of two bilateral hand allotransplantations at six and three years follow-up.
abstract: We report a six and three years follow-up clinical evaluation of two bilateral hand allotransplantations from brain-dead multi-organs donors performed in two young adult traumatic hand amputees. Lifelong immunosuppressive treatment included tacrolimus, mycophenolate mofetil and prednisolone. In both patients, early complications were observed but were successfully treated. At follow-up, clinical results allow useful hand function in both patients, by far superior to what can be provided by current myoelectric prostheses. Although the long-term risks-benefits ratio of bilateral hand transplantation is still unknown, these two cases demonstrate that this new treatment is feasible. Further experimental and clinical research is needed to better delineate its role in the future of hand surgery.
authors.affiliation: Service de Chirurgie de la Main et du Membre Supérieur, Pavillon M-Orthopédie, Hôpital Edouard-Herriot, Lyon Cedex 03, France.
authors.forename: G
authors.initials: G
authors.lastname: Herzberg
authors.forename: F
authors.initials: F
authors.lastname: Weppe
authors.forename: N
authors.initials: N
authors.lastname: Masson
authors.forename: X
authors.initials: X
authors.lastname: Gueffier
authors.forename: L
authors.initials: L
authors.lastname: Erhard
mesh_terms: D000328:Adult; D000673:Amputation, Traumatic / Q000000981:diagnostic imaging / Q000601:surgery*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005500:Follow-Up Studies; D006230:Hand Injuries / Q000000981:diagnostic imaging / Q000601:surgery*; D063987:Hand Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D016559:Tacrolimus / Q000627:therapeutic use; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D011239:Prednisolone; D009173:Mycophenolic Acid; D016559:Tacrolimus