[A simple kinetic model for dynein oscillatory activity].
A kinetic model for dynein, a molecular motor, complexed with microtubule fragments, is considered. The model explains the experimental observations of oscillatory movements in surprisingly simple axonemal fragments perfused by the ATP solution. The model explains at first time the oscillatory dynein activity as a phenomenon induced by two dynein heads cooperative interaction in the axoneme. The oscillation form, frequency, and amplitude, observed for the model, are close to these experimental characteristics. Kinetic parameters, used in the model, are close to the known experimental parameters.
Gol'dshteĭn
B N
BN
Aksirov
A M
AM
Zakrzhevskaia
D T
DT
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D004398:Dyneins / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological
D004398:Dyneins