title: Intestinal permeability in Hymenolepis nana as reflected by non invasive lactulose/mannitol dual permeability test and its impaction on nutritional parameters of patients.
abstract: Assessment of Hymenolepis nana infection among 102 children and adults of both sexes (5-16 years) residing 2 Welfare Institutes (Giza and Cairo) showed a prevalence of 22.33%. The effect of H. nana on intestinal permeability and on nutritional parameters of patients was studied. A total of 46 subjects were divided into 2 groups: GI (20 H. nana patients) and GII (26 parasite-free control). Both groups were subjected to lactulose/mannitol dual permeability test, anthropometric study, estimation of vitamin B12 and folate levels in plasma and estimation of haemoglobin (HB)%, RBCs and WBCs counts and haematocrite value (HCT%) for anaemia. The H. nana patients showed significant higher percent (P = 0.04) of altered intestinal permeability versus controls denoting intestinal leakage, significant means lower levels of vitamin B12 (P = 0.01) and folate (P < 0.04) in blood plasma versus control denoting liability to vitamin B12 & folate deficiencies. Means value of HB%, RBC & WBC counts and HCT% showed generalized decrease but without significant difference in H. nana patients and control denoting anaemia liability. The percent of stunting (HAZ < or =2) and of wasting (WAZ < or =2) were higher among H. nana patients versus controls but without significant difference (P = 0.19 & P = 0.47 respectively).
authors.affiliation: Department of Nutrition, National Research Center Al Azhar University, Nasr City, Egypt.
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Mohammad
authors.forename: Mai A
authors.initials: MA
authors.lastname: Hegazi
mesh_terms: D000293:Adolescent; D000818:Animals; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D006925:Hymenolepiasis / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D048189:Hymenolepis nana / Q000254:growth & development* / Q000302:isolation & purification; D007408:Intestinal Absorption; D007792:Lactulose; D008297:Male; D008353:Mannitol; D009752:Nutritional Status; D010539:Permeability; D015995:Prevalence; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D008353:Mannitol; D007792:Lactulose; D005492:Folic Acid; D014805:Vitamin B 12