Potential use of antiviral agents in polio eradication.
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000. Although important progress has been made, polio remains endemic in several countries. Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era. A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection.
De Palma
Armando M
AM
University of Leuven, Leuven, Belgium.
Pürstinger
Gerhard
G
Wimmer
Eva
E
Patick
Amy K
AK
Andries
Koen
K
Rombaut
Bart
B
De Clercq
Erik
E
Neyts
Johan
J
D000998:Antiviral Agents / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D011051:Poliomyelitis / Q000188:drug therapy / Q000517:prevention & control*; D017955:Poliovirus / Q000187:drug effects* / Q000502:physiology; D011485:Protein Binding; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D014764:Viral Proteins