Dynamic moment analysis of the extracellular electric field of a biologically realistic spiking neuron.
Based on the membrane currents generated by an action potential in a biologically realistic model of a pyramidal, hippocampal cell within rat CA1, we perform a moment expansion of the extracellular field potential. We decompose the potential into both inverse and classical moments and show that this method is a rapid and efficient way to calculate the extracellular field both near and far from the cell body. The action potential gives rise to a large quadrupole moment that contributes to the extracellular field up to distances of almost 1 cm. This method will serve as a starting point in connecting the microscopic generation of electric fields at the level of neurons to macroscopic observables such as the local field potential.
Milstein
Joshua N
JN
California Institute of Technology, Pasadena, CA 91125, USA. milstein@caltech.edu
Koch
Christof
C
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D004574:Electromagnetic Fields; D005110:Extracellular Space / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D019044:Image Cytometry; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology*; D051381:Rats