title: Total synthesis and determination of relative and absolute configuration of multiplolide A.
abstract: A flexible approach for total syntheses of possible multiplolide A diastereomers establishing the relative and absolute configuration is documented. The adopted strategy features ring-closing metathesis (RCM) as the key reaction and screening of a set of substrates for the feasibility of RCM in general and for the requisite E-configuration of ring olefin in particular. Selective protecting groups manipulation prior to the assembly of the central macrocyclic core was instrumental in installing the epoxide functionality on a fully deprotected nonenolide at the end of the synthesis.
authors.affiliation: National Chemical Laboratory, Pune, India. vr.chepuri@ncl.res.in
authors.forename: C V
authors.initials: CV
authors.lastname: Ramana
authors.forename: Tushar P
authors.initials: TP
authors.lastname: Khaladkar
authors.forename: Soumitra
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Mukund K
authors.initials: MK
authors.lastname: Gurjar
mesh_terms: D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D007783:Lactones; C435879:multiplolide A