How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits.
Sack
Jon T
JT
ternational Centre for Neurotherapeutics, Dublin City University, Dublin 9, Ireland. jon.sack@ididrugs.org
Shamotienko
Oleg
O
Dolly
J Oliver
JO
D000818:Animals; D054316:Biomarkers, Pharmacological; D015195:Drug Design; D015870:Gene Expression; D006801:Humans; D007473:Ion Channels / Q000187:drug effects* / Q000235:genetics*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D015202:Protein Engineering / Q000639:trends; D021122:Protein Subunits / Q000235:genetics*
D054316:Biomarkers, Pharmacological; D007473:Ion Channels; D004364:Pharmaceutical Preparations; D021122:Protein Subunits