title: HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004.
abstract: We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.
authors.affiliation: Paediatric Infectious Diseases Unit, St. George's Hospital, London. rchakrab@sgul.ac.uk
authors.forename: Rana
authors.initials: R
authors.lastname: Chakraborty
authors.forename: Colette J
authors.initials: CJ
authors.lastname: Smith
authors.forename: David
authors.initials: D
authors.lastname: Dunn
authors.forename: Hannah
authors.initials: H
authors.lastname: Green
authors.forename: Trinh
authors.initials: T
authors.lastname: Duong
authors.forename: Katja
authors.initials: K
authors.lastname: Doerholt
authors.forename: Andrew
authors.initials: A
authors.lastname: Riordon
authors.forename: Hermione
authors.initials: H
authors.lastname: Lyall
authors.forename: Pat
authors.initials: P
authors.lastname: Tookey
authors.forename: Karina
authors.initials: K
authors.lastname: Butler
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Sabin
authors.forename: Di
authors.initials: D
authors.lastname: Gibb
authors.forename: Deenan
authors.initials: D
authors.lastname: Pillay
mesh_terms: D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D020125:Mutation, Missense; D006113:United Kingdom