title: High-throughput kinase profiling as a platform for drug discovery.
abstract: To fully exploit the potential of kinases as drug targets, novel strategies for the efficient discovery of inhibitors are required. In contrast to the traditional, linear process of inhibitor discovery, high-throughput kinase profiling enables a parallel approach by interrogating compounds against hundreds of targets in a single screen. Compound potency and selectivity are determined simultaneously, providing a choice of targets to pursue that is guided by the quality of lead compounds available, rather than by target biology alone.
authors.affiliation: Roche Palo Alto, 3431 Hillview Avenue, R6-201, Palo Alto, California 94304, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Goldstein
authors.forename: Nathanael S
authors.initials: NS
authors.lastname: Gray
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Zarrinkar
mesh_terms: D015195:Drug Design; D006801:Humans; D040081:Protein Array Analysis; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases