title: (C)Re-combining textbook models of virus spread within the host.
abstract: Classic viral pathogenesis models postulate that tissues supporting efficient virus replication promote virus dissemination, which culminates in clinical illness. In this issue of Cell Host & Microbe, Sacher and colleagues use Cre/loxP recombination to label murine cytomegalovirus during replication in distinct cell types in vivo. Strikingly, they demonstrate that the most productive cell type in the host-the hepatocyte-contributes no progeny to dissemination to other tissues.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. esbarton@purdue.edu
authors.forename: Erik S
authors.initials: ES
authors.lastname: Barton
authors.forename: Douglas W
authors.initials: DW
authors.lastname: White
mesh_terms: D000818:Animals; D005818:Genetic Engineering / Q000379:methods*; D049452:Green Fluorescent Proteins / Q000235:genetics; D006566:Herpesviridae Infections / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D019426:Integrases / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D018146:Muromegalovirus / Q000502:physiology*; D011995:Recombination, Genetic
chemical_list: C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; C045073:Cre recombinase; D019426:Integrases