title: Seasonal variations of exposure biomarkers, oxidative stress responses and cell damage in the clams, Tapes philippinarum, and mussels, Mytilus galloprovincialis, from Adriatic sea.
abstract: This work investigated the natural variability of several biomarkers in Tapes philippinarum and Mytilus galloprovincialis, sampled from Northern Adriatic where these organisms are important sentinel species for future environmental impact assessment. Levels of metallothioneins, peroxisomal enzymes and acetylcholinesterase, showed a significant seasonality and marked differences between clams and mussels. Among antioxidant enzymes, catalase and GST decreased during the warmer period, the latter enzyme activity resulting particularly high in clams. The total oxyradical scavenging capacity toward peroxyl radicals decreased in mussels from winter to summer, indicating a prooxidant challenge due to higher seawater temperature and intensity of light irradiance. Lysosomal membrane stability did not exhibit significant seasonal variations, while some variations were observed for DNA damages. Overall results indicated a significant influence of seasonal variability on several biomarkers and species-specific differences which should be considered to discriminate the appearance of anthropogenic disturbance.
authors.affiliation: Istituto di Biologia e Genetica, Università Politecnica delle Marche, Via Ranieri Montedago 65, Ancona, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bocchetti
authors.forename: Claudia Virno
authors.initials: CV
authors.lastname: Lamberti
authors.forename: Barbara
authors.initials: B
authors.lastname: Pisanelli
authors.forename: Erika M
authors.initials: EM
authors.lastname: Razzetti
authors.forename: Chiara
authors.initials: C
authors.lastname: Maggi
authors.forename: Barbara
authors.initials: B
authors.lastname: Catalano
authors.forename: Giulio
authors.initials: G
authors.lastname: Sesta
authors.forename: Giacomo
authors.initials: G
authors.lastname: Martuccio
authors.forename: Massimo
authors.initials: M
authors.lastname: Gabellini
authors.forename: Francesco
authors.initials: F
authors.lastname: Regoli
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D049872:Bivalvia / Q000166:cytology* / Q000378:metabolism*; D019083:Mediterranean Region; D049878:Mytilus / Q000166:cytology* / Q000378:metabolism*; D009792:Oceans and Seas; D018384:Oxidative Stress / Q000502:physiology*; D025341:Principal Component Analysis; D012621:Seasons
chemical_list: D015415:Biomarkers