Including MIR of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor.
The authors present a case of a 42-year-old female who developed a leiomyosarcoma of the right proximal tibia that appeared radiologically similar to a giant cell tumor Histology revealed spindle cells running in whorl-like fashion with focal atypia and low mitotic figures. The immuno-stains revealed positive reactivity for alpha-smooth muscle (SMA), muscle actin and cytokeratin (AE1/AE3). The authors rendered a diagnosis of low-grade leiomyosarcoma of bone. The lesion was considered a primary lesion since the patient did not have other leiomyomatous tumors. The MRI showed hypo- to iso- signal intensity on T1-weighted imaging and heterogeneous intensity on T2-weighted imaging. This was likely due to admixed fibrotic tissue in the lesion. The tumor cells were not positive for Ebstein-Barr virus by in-situ hybridization as seen in leiomyomatous tumors in immunodeficiency patients.
Sirikulchayanonta
Vorachai
V
Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. vorachai7@yahoo.com
Jaovisidh
Suphaneewan
S
D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005870:Giant Cell Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging* / Q000473:pathology