Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles.
We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SNAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,N-disubstituted 2-amino-1,3,4-oxadiazoles, which are difficult to prepare using existing synthetic strategies.
Levins
Christopher G
CG
Chemical and Screening Sciences, Wyeth Research, Cambridge, MA 02140, USA.
Wan
Zhao-Kui
ZK
D000586:Amination; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D009943:Organophosphorus Compounds; D010069:Oxadiazoles; C031032:benzotriazol-1-yloxy-tris(dimethylamino)phosphonium