A tRNA with oncogenic capacity.
Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform cells in vitro and cause tumor formation in vivo. Marshall et al. (2008) now show that one of the transcriptional products of RNA polymerase III, the initiator tRNA(Met), mediates this effect, revealing an unexpected role for this tRNA in tumorigenesis.
Berns
Anton
A
Division of Molecular Genetics, Cancer Genomics Centre, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. a.berns@nki.nl
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008954:Models, Biological; D012320:RNA Polymerase III / Q000378:metabolism; D012358:RNA, Transfer, Met / Q000235:genetics / Q000378:metabolism*; D035361:Transcription Factor TFIIIB / Q000378:metabolism; D014158:Transcription, Genetic
D012358:RNA, Transfer, Met; D035361:Transcription Factor TFIIIB; D012320:RNA Polymerase III