Increased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment.
Heat shock proteins (Hsps) have been regarded as cytoprotectants that protect brain cells from damage encountered following cerebral ischemia or during the progression of neurodegenerative diseases. In this study, we assessed the plasma Hsp70 and Hsp27 levels in not cognitively impaired (NCI) subjects and in patients with mild cognitive impairment (MCI), vascular mild cognitive impairment (VMCI), and probable Alzheimer's disease (AD). Comparison of the plasma Hsp70 and Hsp27 levels of the 4 groups revealed that only the plasma Hsp70 level of VMCI patients (14.11 ng/ml) was significantly higher than that of NCI subjects (11.32 ng/ml), MCI patients (10.16 ng/ml), and patients with probable AD (10.16 ng/ml) after adjustment of age, sex, and education (F=4.231, d.f.=3, p=0.008). Furthermore, there was no difference in plasma Hsp27 levels among the 4 groups. These findings suggest that the plasma Hsp70 level may be related to vascular factors or inflammation.
Lee
Kang Soo
KS
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Chung
Ji Hyung
JH
Oh
Byung Hoon
BH
Hong
Chang Hyung
CH
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood* / Q000145:classification / Q000209:etiology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006360:Heat-Shock Proteins / Q000097:blood; D006801:Humans; D008297:Male
D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins