[Prospective, multicenter study of mortality and risk factors in children with acute respiratory distress syndrome in 25 pediatric intensive care units in China].
OBJECTIVE
To investigate the mortality and predictors of outcome of children with acute respiratory distress syndrome (ARDS) in pediatric intensive care unit (PICU).


METHODS
ARDS cases were selected from the 12 018 patients admitted in 25 pediatric intensive care units in China from January 1 to December 31, 2004, aged 29 days to 14 years, using the Chinese Pediatric Critical Index of Severity (PCIS) and American Guidelines for Admission and Discharge Policies for PICU. ARDS was diagnosed according to the 1994 American-European Consensus Conference criteria.


RESULTS
105 of the 12 018 patients (1.44%) were diagnosed as with ARDS. The overall mortality of ARDS was 61.0% (64/105), 9 times as high as that of the 7269 severe cases in PICU. Logistic regression analysis showed that infiltration shadows in 2 - 3 quadrants, pediatric critical illness score (PCIS), and partial pressure of carbon dioxide (PaCO2) at the onset of ARDS were independently associated with the mortality.


CONCLUSIONS
ARDS has a high risk of death, and the infiltration shadows in 2-3 quadrants, PCIS, and PaCO2 are independently associated with mortality.
Yu
Wen-Liang
WL
Laboratory of Pediatric Respiratory and Critical Care Medicine, Children's Hospital of Fudan University, Shanghai 200032, China.
Qian
Su-Yun
SY
Zhu
You-Rong
YR
Hou
Xin-Guang
XG
Li
Mei
M
Tang
Ding-Hua
DH
Li
Li-Hong
LH
Mi
Yue-Qun
YQ
Yu
Yi
Y
Fan
Xun-Mei
XM
Sun
Bo
B
D000208:Acute Disease; D000293:Adolescent; D044466:Asian People / Q000706:statistics & numerical data*; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D008171:Lung Diseases / Q000208:ethnology / Q000401:mortality*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors