title: Synthesis of some novel quinolines and pyrimido [4,5-b] quinolines bearing A sulfonamide moiety as potential anticancer and radioprotective agents.
abstract: Some novel 4-(quinolin-1-yl)-benzenesulfonamide and 4-(pyrimido[4,5-b]quinolin-10-yl)-benzenesulfonamide derivatives have been synthesized. All the newly synthesized target compounds were subjected to in vitro cytotoxic screening to be evaluated for their anticancer activity against Ehrlich ascites carcinoma cells. Among these new compounds, compounds 9a, 11, 12b, 18 and, in particular, 19 showed promising in vitro cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug. Moreover, compound 8 exhibited in vivo radioprotective activity against gamma-irradiation in mice.
authors.affiliation: Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt. mmsghorab@yahoo.com
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Ghorab
authors.forename: Fatma A
authors.initials: FA
authors.lastname: Ragab
authors.forename: Eman
authors.initials: E
authors.lastname: Noaman
authors.forename: Helmy I
authors.initials: HI
authors.lastname: Heiba
authors.forename: Ebaa M
authors.initials: EM
authors.lastname: El-Hossary
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood; D006801:Humans; D007202:Indicators and Reagents; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D008054:Lipid Peroxides; D011744:Pyrimidinones; D015363:Quinolones; D011837:Radiation-Protective Agents; D013449:Sulfonamides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione