title: Design and implementation of a high-throughput biological sample processing facility using modern manufacturing principles.
abstract: BACKGROUND
  UK Biobank is a prospective study that is collecting biological samples and health and lifestyle data from 500 000 volunteer participants over a 4-year period. These data will be used to facilitate biological and medical research.
  
  
  METHODS
  Modern manufacturing principles were used to direct the development of the sample processing facility and automated systems.
  
  
  RESULTS
  A fit for purpose facility comprising technology, systems, dedicated process, infrastructure and an appropriate staff structure has been implemented that will deliver and maintain a resource that will support the long-term goals of the UK Biobank study.
  
  
  CONCLUSIONS
  Modern manufacturing principles are appropriate for use in the development of a high throughput biological sample processing facility.
authors.affiliation: UK Biobank, Unit 1 Spectrum Way, Cheadle, Stockport, Cheshire SK3 0SA, UK. paul.downey@ukbiobank.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: Downey
authors.forename: Tim C
authors.initials: TC
authors.lastname: Peakman
mesh_terms: D001322:Autoanalysis; D018070:Biological Specimen Banks / Q000458:organization & administration / Q000592:standards*; D001698:Biomedical Engineering; D020811:Biomedical Technology; D005160:Facility Design and Construction / Q000592:standards*; D006801:Humans; D017410:Practice Guidelines as Topic; D011786:Quality Control; D013048:Specimen Handling / Q000379:methods*; D006113:United Kingdom