Antibody response to hepatitis A immunization among human immunodeficiency virus-infected children and adolescents.
Seventy-one of 84 human immunodeficiency virus (HIV)-infected children [84.5% (95% confidence interval: 75-91.5%)] were hepatitis A virus (HAV) seropositive after 2 doses of HAV vaccine. Higher CD4% and HIV suppression were significantly associated with increased HAV seropositivity rate. In multivariate analysis, CD4 >or=25% and young age were independent predictors of HAV seropositivity. Of 7 children given a third HAV vaccine dose because of negative HAV antibody after 2 doses, 2 (29%) became seropositive.
Siberry
George K
GK
Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA. gsiberr1@jhmi.edu
Coller
Ryan J
RJ
Henkle
Emily
E
Kiefner
Carolyn
C
Joyner
Mary
M
Rogers
Jamie
J
Chang
Jennifer
J
Hutton
Nancy
N
D000293:Adolescent; D000367:Age Factors; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006506:Hepatitis A / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000097:blood*; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D019562:Viral Load
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines