title: Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.
abstract: We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
authors.affiliation: Chemistry Department, University of Bath, Claverton Down, UKBA2 7AY. s.pascu@bath.ac.uk
authors.forename: Sofia I
authors.initials: SI
authors.lastname: Pascu
authors.forename: Philip A
authors.initials: PA
authors.lastname: Waghorn
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Conry
authors.forename: Bonita
authors.initials: B
authors.lastname: Lin
authors.forename: Helen M
authors.initials: HM
authors.lastname: Betts
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dilworth
authors.forename: Robert B
authors.initials: RB
authors.lastname: Sim
authors.forename: Grant C
authors.initials: GC
authors.lastname: Churchill
authors.forename: Franklin I
authors.initials: FI
authors.lastname: Aigbirhio
authors.forename: John E
authors.initials: JE
authors.lastname: Warren
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013882:Thiosemicarbazones / Q000737:chemistry*; D018675:Toxicity Tests; D015032:Zinc / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D015032:Zinc