title: Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines.
abstract: A direct solid-phase synthesis of a series of substituted benzimidazole-containing peptides is described. The method involves on-resin formation of new amino acids containing benzimidazole derivatives in the side chain. The heterocycle conjugates were obtained by reaction between aldehydes and peptides containing beta-(3,4-diaminophenyl)alanine residue, immobilized on a polymeric solid support.
authors.affiliation: Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Koprowska-Ratajska
authors.forename: Alicja
authors.initials: A
authors.lastname: Kluczyk
authors.forename: Piotr
authors.initials: P
authors.lastname: Stefanowicz
authors.forename: Hubert
authors.initials: H
authors.lastname: Bartosz-Bechowski
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szewczuk
mesh_terms: D000409:Alanine / Q000737:chemistry*; D006690:Bisbenzimidazole / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D010455:Peptides; D006690:Bisbenzimidazole; D000409:Alanine