Predicting 3D structures of protein-protein complexes.
The protein-protein docking problem is one of the focal points of activity in computational structural biology. Adequate computational techniques for structural modeling of protein interactions are important because of the growing number of known protein structures, particularly in the context of structural genomics. The protein docking methodology offers tools for fundamental studies of protein interactions and provides structural basis for drug design. The paper presents a critical review of the existing protein-protein docking approaches in view of the fundamental principles of protein recognition.
Vakser
Ilya A
IA
Center for Bioinformatics, The University of Kansas, Lawrence, Kansas 66047, USA. vakser@ku.edu
Kundrotas
Petras
P
D000465:Algorithms; D000595:Amino Acid Sequence; D001665:Binding Sites; D021621:Imaging, Three-Dimensional / Q000379:methods; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D020539:Sequence Analysis, Protein / Q000379:methods*
D011506:Proteins