Effect of statins on serum apolipoprotein j and paraoxonase-1 levels in patients with ischemic heart disease undergoing coronary angiography.
It has been proposed that apolipoprotein J (apo J) and paraoxonase-1 (PON1) correlate with the extent and severity of ischemic heart disease (IHD). This article compares apo J and PON1 serum concentrations, PON1 activity, and the apo J/PON1 ratio in 138 IHD patients (64 statins users and 74 statin nonusers) referred for angiography and possible percutaneous coronary intervention. The effect of statin treatment on apo J and PON1 concentrations, PON1 activity, and the degree of coronary artery stenosis were evaluated. In both groups, apo J levels were increased, whereas PON1 concentration and activity decreased. IHD patients on statins had significantly lower apo J concentration and higher PON1 concentration and activity. Patients on statins had less coronary artery stenosis. High apo J levels, low PON1 levels, low PON1 activity, and a high apo J/PON1 ratio were associated with IHD. Statin treatment reverses these changes, probably by multiple beneficial actions.
Poulakou
Maria V
MV
National and Kapodistrian University of Athens, Greece.
Paraskevas
Kosmas I
KI
Vlachos
Ioannis S
IS
Karabina
Sonia-Athena P
SA
Wilson
Mark R
MR
Iliopoulos
Dimitrios C
DC
Tsitsilonis
Serafim I
SI
Mikhailidis
Dimitri P
DP
Perrea
Despina N
DN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000187:drug effects; D051152:Clusterin / Q000097:blood* / Q000187:drug effects; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012720:Severity of Illness Index
C495242:CLU protein, human; D051152:Clusterin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human