[Correlation between lymph-node metastasis and combined expression of Hpa and C-erbB-2 of invasive ductal breast carcinoma].
OBJECTIVE
This study is to learn the correlation between lymph-node metastasis and the combined expression of Heparanase (Hpa) and C-erbB-2.


METHODS
The expressions of Hpa and C-erbB-2 were examined in 81 human invasive ductal breast carcinomas ( IDBC ) and 14 fibroadenomas by SP immunohistochemistry analysis. We analyzed the expressions of two factors in two groups, in which their correlation with lymph-node metastasis in IDBC was also studied.


RESULTS
(1) Positive expressions of Hpa and C-erbB-2 in IDBC tissue were 59 (72.84%) and 29(35. 80%) respectively, in which the positive expression rates were significantly higher than those in fibroadenomas (P = 0.0000, 0.0177). (2) The expression of C-erbB-2 was correlated with Hpa expression (r = 0.668, P < 0.01). (3) When Hpa expression was combined with the status of C-erbB-2 expression, the lymph node metastasis with positive-Hpa and positive-C-erbB-2 expressions occurred significantly higher in patients with IDBC (all P < 0.01).


CONCLUSIONS
Hpa may up-regulate the expression of C-erbB-2. Furthermore, as co-expression, Hpa and C-erbB-2 work together, which would take the possession of stronger role in the procedure of growth, invasion and metastasis of IDBC.
Zheng
Xiao-dong
XD
Department of Breast, Institute of Tumor, Chongqing 400030, China.
Xiao
Chun-bo
CB
Mao
Da-hua
DH
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D055815:Young Adult; D000099175:Heparanase
D014408:Biomarkers, Tumor; D005966:Glucuronidase; D018719:Erb-b2 Receptor Tyrosine Kinases; D000099175:Heparanase; C508053:ERBB2 protein, human