Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice.
Fifteen derivatives of falconensin were examined for their inhibitory activity against the induction of ear edema in mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects. All compounds tested, except monomethylmitorubrin, inhibited the inflammatory activity induced by TPA.
Yasukawa
Ken
K
Itabashi
Takeshi
T
Kawai
Ken-ichi
K
Takido
Michio
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D032842:Emericella / Q000737:chemistry*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone; D013755:Tetradecanoylphorbol Acetate; D007213:Indomethacin