title: AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia.
abstract: Pre-eclampsia is a common, pregnancy-induced disorder, consisting of hypertension and proteinuria. The condition is one of the leading causes for maternal and perinatal morbidity and mortality. Nonetheless, the underlying molecular mechanisms remain unclear. Immunological mechanisms and the renin-angiotensin system have been implicated in the development of pre-eclampsia. Agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) have been identified in pre-eclamptic patients, unifying the two hypothesis. Evidence has also accumulated for the existence and importance of a local, utroplacental renin-angiotensin system. We summarize recent data emphasizing the pathophysiological role for the autoantibodies and the uteroplacental renin-angiotensin system.
authors.affiliation: Medical Faculty of the Charité, Franz-Volhard Clinic, HELIOS Clinic, Berlin, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Herse
authors.forename: Anne Cathrine
authors.initials: AC
authors.lastname: Staff
authors.forename: Lydia
authors.initials: L
authors.lastname: Hering
authors.forename: Dominik N
authors.initials: DN
authors.lastname: Müller
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D021041:Placental Circulation / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D012084:Renin-Angiotensin System / Q000276:immunology*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D040281:Vascular Endothelial Growth Factor Receptor-1