Capillary electrophoresis for pharmaceutical analysis.
This chapter describes the application of capillary electrophoresis (CE) to pharmaceutical analysis. The areas of pharmaceutical analysis covered are enantiomer separation, analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, related substances determinations, and physiochemical measurements such as log P and pKa of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details. Information on electrolyte choice and method optimization to obtain optimal separations is included.
Marsh
Alex
A
GlaxoSmithKline Research & Development, Harlow, Essex, UK.
Broderick
Margo
M
Altria
Kevin
K
Power
Joe
J
Donegan
Sheila
S
Clark
Brian
B
D000900:Anti-Bacterial Agents / Q000032:analysis; D002241:Carbohydrates / Q000032:analysis; D020374:Chromatography, Micellar Electrokinetic Capillary; D043844:Crown Ethers / Q000032:analysis; D003505:Cyclodextrins / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D011506:Proteins / Q000032:analysis; D015203:Reproducibility of Results; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D043844:Crown Ethers; D003505:Cyclodextrins; D004364:Pharmaceutical Preparations; D011506:Proteins