title: Local intra-arterial eptifibatide for intraoperative vessel thrombosis during aneurysm coiling.
abstract: We report on our experience with the intra-arterial administration of eptifibatide for thrombolysis during aneurysm-embolization procedures. In 4 cases (3 stent-assisted coiling procedures and 1 with posthemorrhagic vasospasm), we noted the formation of thrombus occluding a vessel. We administered eptifibatide (10-15 mg) through a microcatheter proximal to the thrombus. The thrombus rapidly dissolved, resulting in the recanalization of the occluded vessels with no rethrombosis or hemorrhagic complications.
authors.affiliation: Neurosurgical Department, Papanikolaou General Hospital, Thessaloniki, Greece. vkats@iname.com
authors.forename: V
authors.initials: V
authors.lastname: Katsaridis
authors.forename: C
authors.initials: C
authors.lastname: Papagiannaki
authors.forename: N
authors.initials: N
authors.lastname: Skoulios
authors.forename: I
authors.initials: I
authors.lastname: Achoulias
authors.forename: D
authors.initials: D
authors.lastname: Peios
mesh_terms: D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000628:therapy; D015901:Angiography, Digital Subtraction; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000628:therapy; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D000077542:Eptifibatide; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007261:Infusions, Intra-Arterial; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy*; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007431:Intraoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D015607:Stents; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000628:therapy; D015912:Thrombolytic Therapy; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D006493:Heparin; D000077542:Eptifibatide