An unusual association between familial mediterranean fever and IgM nephropathy.
OBJECTIVE
To report a case with the diagnosis of IgM nephropathy and familial Mediterranean fever (FMF).


METHODS
A 9-year-old boy was admitted to our hospital with recurrent abdominal pain since the age of 4 years. Laboratory investigations revealed a sedimentation rate of 88 mm/h, C-reactive protein: 83.2 mg/l (0-10 mg/l), white blood cell count: 12,700/mm(3), fibrinogen: 622 mg/dl (200-400 mg/dl) and serum amyloid A: 186 mg/l (0-5.8 mg/l). Urinalysis revealed +2 proteinuria. A 24-hour urinary protein excretion was 12 mg/m(2)/h. M694V homozygous mutation was identified in exon 10. Percutaneous renal biopsy showed mesangial cell proliferation and increased mesangial matrix in the glomeruli, without amyloid accumulation. Immunofluorescence study showed IgM (+1) and C1q (+1) deposits. Treatment with 1 mg/day colchicine was started. Six weeks later, proteinuria had disappeared and the patient was asymptomatic.


CONCLUSIONS
This case illustrates the unusual association of FMF with non-amyloid glomerulopathy. Glomerular diseases such as IgM nephropathy may be seen as a manifestation of FMF.
Peru
Harun
H
Department of Pediatric Nephrology, Faculty of Meram Medicine, Selcuk University, Konya, Turkey. harunperu@gmail.com
Elmaci
Ahmet Midhat
AM
Akin
Fatih
F
Akcoren
Zuhal
Z
Orhan
Diclehan
D
D002648:Child; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005921:Glomerulonephritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D050257:Tubulin Modulators / Q000627:therapeutic use
D007075:Immunoglobulin M; D050257:Tubulin Modulators; D003078:Colchicine