Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review.
The physical properties of digesta may influence mixing, efficiency of digestion, and absorption within the lumen of the intestine. We review how the physical properties of digesta change during transit through the various segments of the intestine, and how their influence on flow and mixing may be modulated by peristaltic activity. We examine how, in more fluid digesta, the solid and liquid phases interact to influence flow and mixing. Similarly, how in viscid digesta, shear strength, plasticity and elasticity of contained particulate material may influence the permeation of the fluid phase and secretions into and out of the digesta bolus. The manner in which the solid and liquid phases of digesta interact in a partly gaseous environment, such as the lower bowel, to influence bolus cohesion is also examined. Those mechanisms that promote the formation of a less viscous layer at the mucosal interface to promote plug flow are reviewed, and their effect on the efficiency of mixing and digestion discussed. It is recommended that in any future work investigating the character of mixing in the intestine, a wider range of appropriate digesta properties be measured and that, in investigations of intestinal movement, perfusates with similar characteristics to digesta be used.
Lentle
R G
RG
Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand. r.g.lentle@massey.ac.nz
Janssen
P W M
PW
D000818:Animals; D004063:Digestion / Q000502:physiology*; D004548:Elasticity; D005502:Food; D005766:Gastrointestinal Contents / Q000737:chemistry*; D005769:Gastrointestinal Motility; D005772:Gastrointestinal Transit; D007408:Intestinal Absorption; D007422:Intestines / Q000502:physiology*; D023421:Models, Animal; D008954:Models, Biological; D010316:Particle Size; D010528:Peristalsis; D010539:Permeability; D012212:Rheology; D033081:Shear Strength; D014783:Viscosity