title: Assessment of aortic pulse wave velocity and cardiac diastolic function in subjects with and without the metabolic syndrome: HDL cholesterol is independently associated with cardiovascular function.
abstract: OBJECTIVE
  To evaluate the influence of lipid and glucose metabolism in the metabolic syndrome on aortic pulse wave velocity (PWV) and left ventricular (LV) diastolic function using magnetic resonance imaging (MRI).
  
  
  METHODS
  Aortic PWV and LV diastolic function were assessed using MRI in 16 subjects with the metabolic syndrome and 16 subjects without the metabolic syndrome matched for age, waist circumference, and blood pressure. The groups were compared using the unpaired t test or Mann-Whitney U test, and linear regression analysis was applied.
  
  
  RESULTS
  Aortic PWV was increased and LV diastolic function was decreased in subjects with compared with those without the metabolic syndrome. HDL cholesterol was independently associated with aortic PWV (R = -0.470, P < 0.01) and LV diastolic function (R = -0.421, P = 0.02).
  
  
  CONCLUSIONS
  Increased aortic PWV and decreased LV diastolic function is observed in subjects with the metabolic syndrome, regardless of blood pressure. Moreover, HDL cholesterol is independently associated with aortic PWV and LV diastolic function.
authors.affiliation: Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. s.d.roes@lumc.nl
authors.forename: Stijntje D
authors.initials: SD
authors.lastname: Roes
authors.forename: Reza
authors.initials: R
authors.lastname: Alizadeh Dehnavi
authors.forename: Jos J M
authors.initials: JJ
authors.lastname: Westenberg
authors.forename: Hildo J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: Bart J A
authors.initials: BJ
authors.lastname: Mertens
authors.forename: Jouke T
authors.initials: JT
authors.lastname: Tamsma
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000368:Aged; D001011:Aorta / Q000502:physiology* / Q000503:physiopathology; D001783:Blood Flow Velocity; D008076:Cholesterol, HDL / Q000097:blood*; D003971:Diastole / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D011674:Pulse; D012016:Reference Values; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D008076:Cholesterol, HDL