Intermolecular radical addition reactions of alpha-iodo cycloalkenones and a synthetic study of the formal synthesis of enantiopure fawcettimine.
The generation of alpha-carbonyl vinyl radicals from alpha-iodo cycloalkenones, the scope of their participation in intermolecular addition reactions with electron-withdrawing olefins are studied and a synthetic study of the formal synthesis of enantiopure fawcettimine using this reaction is described.
Liu
Kuan-Miao
KM
School of Applied Chemistry, Chung Shan Medical University, Taichung 402, Taiwan, ROC. lkm@csmu.edu.tw
Chau
Chi-Min
CM
Sha
Chin-Kang
CK
D000470:Alkaloids / Q000737:chemistry*; D000478:Alkylation; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000737:chemistry; D004583:Electrons; D005609:Free Radicals / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000470:Alkaloids; D003516:Cycloparaffins; D005609:Free Radicals; D007211:Indoles; C524731:fawcettimine