title: Prevalence of metabolic syndrome in patients with clinically advanced peripheral vascular disease.
abstract: The aim of this cross-sectional study was to determine the prevalence of metabolic syndrome (MetS) and its components among 100 patients with progressive peripheral arterial disease (PAD) referred for diagnostic angiography in preparation for a revascularization procedure. The prevalence of MetS was more than 95%. Diabetes mellitus was the most prevalent component followed by hypertension and low high-density lipoprotein. Almost half the patients aggregated in the highest metabolic score category. A direct relationship was identified between the number of MetS components and serum uric acid (P = .001) and C-reactive protein (P = .826), whereas an inverse relationship was seen between the clustering of components and androgen levels in men (P < .001). For PAD, which could have a benign clinical course, early screening for MetS might identify those at greater risk of failing conservative therapy and progressing to a more aggressive atherosclerotic disease typically associated with high morbidity and mortality.
authors.affiliation: Department of Medicine-Endocrinology, Kuwait University, Kuwait. lailaqadan@hotmail.com
authors.forename: Laila R
authors.initials: LR
authors.lastname: Qadan
authors.forename: Adel A
authors.initials: AA
authors.lastname: Ahmed
authors.forename: Hussein A
authors.initials: HA
authors.lastname: Safar
authors.forename: Marzouk A
authors.initials: MA
authors.lastname: Al-Bader
authors.forename: Amr A
authors.initials: AA
authors.lastname: Ali
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007730:Kuwait / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000453:epidemiology*; D015995:Prevalence; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D014527:Uric Acid; D013739:Testosterone; D002097:C-Reactive Protein