title: Studies on the constituents from the fruits of Phaleria macrocarpa.
abstract: From the fruits of Phaleria macrocarpa, icariside C(3) (1), phalerin (2), and mangiferin (3) were isolated and their structures were identified on the basis of spectroscopic data. Icariside C(3) (1) showed a slow vasorelaxant activity against noradrenaline-induced contraction of isolated rat aorta. The structure of phalerin (2) was revised as 2,4',6-trihydroxy-4-methoxybenzophenone-2-O-beta-D-glucoside.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, 142-8501, Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Oshimi
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Toru
authors.initials: T
authors.lastname: Iizuka
authors.forename: Herra
authors.initials: H
authors.lastname: Studiawan
authors.forename: Gunawan
authors.initials: G
authors.lastname: Indrayanto
authors.forename: Noor Cholies
authors.initials: NC
authors.lastname: Zaini
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C529772:2,4',6-trihydroxy-4-methoxybenzophenone-2-O-glucoside; D001577:Benzophenones; D005960:Glucosides; D010936:Plant Extracts; D012717:Sesquiterpenes; D014665:Vasodilator Agents; D044004:Xanthones; C529773:icariside C3; C013592:mangiferin; D009638:Norepinephrine