Cord compression may rapidly influence the expression of placental angiogenic genes in pre-eclampsia.
Gene expression studies have demonstrated the altered expression level of placental angiogenesis related genes in severe pre-eclampsia (PE). In cord compression, the transportation of oxygen from the placenta to the fetus is blocked, and it is speculated that during blockade the originally hypoxic placenta may become hyperoxic. We compared the placental gene expression profiles of one pre-eclamptic patient with cord compression (the index patient) to the profiles of patients with PE and those of normal pregnancy controls (including one woman with cord compression). The gene expression of the cord compression PE patient resembled that observed in the normal pregnancies. We hypothesize that umbilical blockade may in a short period of time lead to placental hyperoxia, which in turn has an effect on angiogenic gene expression profile.
Järvenpää
J
J
Department of Obstetrics and Gynecology, Oulu University Hospital, PL 24, 90029 OYS, Oulu, Finland. jouko.jarvenpaa@ppshp.fi
Vuoristo
J T
JT
Ukkola
O
O
Hirvikoski
P
P
Savolainen
E-R
ER
Raudaskoski
T
T
Ryynänen
M
M
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics*; D053589:Nuchal Cord / Q000235:genetics; D010920:Placenta / Q000378:metabolism*; D021041:Placental Circulation / Q000235:genetics / Q000502:physiology; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics / Q000473:pathology*; D014470:Umbilical Cord / Q000473:pathology*