title: The effect of hypercholestrolemia on calf muscle hemoglobin oxygen saturation in patients with intermittent claudication.
abstract: The purpose was to compare calf muscle hemoglobin oxygen saturation and exercise performance in hypercholesterolemic and normocholesterolemic patients with peripheral arterial disease. Hypercholesterolemic and normocholesterolemic patients had similar ankle/ brachial index (0.72 +/- 0.24 vs 0.79 +/- 0.28, [mean +/- SD]; P = .334). Hypercholesterolemic patients had shorter initial claudication distance (214 +/- 168 m vs 331 +/- 185 m, P = .026), absolute claudication distance (391 +/- 219 m vs 549 +/- 211 m, P = .035), and lower calf muscle hemoglobin oxygen saturation at the occurrence of initial claudication distance (27 +/- 21% vs 39 +/- 20%; P = .013), and absolute claudication distance (26 +/- 21% vs 36 +/- 21%; P = .021). Hypercholesterolemia is associated with shorter walking distances and calf muscle hemoglobin oxygen saturation during exercise in patients limited by intermittent claudication.
authors.affiliation: Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, USA.
authors.forename: Azhar
authors.initials: A
authors.lastname: Afaq
authors.forename: Polly S
authors.initials: PS
authors.lastname: Montgomery
authors.forename: Kristy J
authors.initials: KJ
authors.lastname: Scott
authors.forename: Steve M
authors.initials: SM
authors.lastname: Blevins
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Whitsett
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Gardner
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005080:Exercise Test; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism* / Q000503:physiopathology; D007383:Intermittent Claudication / Q000378:metabolism* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins; D010100:Oxygen