[Rare thrombophilic states].
OBJECTIVE
Rare thrombophilic states are mostly associated with recurrent venous thrombosis or severe thrombosis such as neonatal purpura fulminans. We review here the various causes of rare thrombophilic states.


BACKGROUND
Rare thrombophilic states associated with recurrent venous thrombosis include the following: antithrombin deficiencies, homozygous for protein C or protein S deficiency or compound heterozygous, double heterozygous for genetic thrombophilia and the rare thrombophilia due to auto-antibodies. Their frequency in patients with venous thromboembolism is below 2%.


CONCLUSIONS
These uncommon thrombophilic states require a treatment in a specialized department.
Emmerich
J
J
Inserm U765, médecine vasculaire - HTA, hôpital européen Georges-Pompidou, université Paris-Descartes, 20, rue Leblanc, 75908 Paris cedex 1, France. joseph.emmerich@egp.aphp.fr
D000991:Antithrombins / Q000235:genetics; D005166:Factor V Deficiency / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D020151:Protein C Deficiency / Q000235:genetics; D018455:Protein S Deficiency / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000235:genetics; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy
D000991:Antithrombins; D011516:Prothrombin