Evaluation of antiaggressive activity of Eclipta alba in experimental animals.
The occurrence of aggression for prolonged periods of time could have a hazardous impact on the health and social wellbeing of the individual. Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma- aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100 and 200mg/kg of aqueous extract of Eclipta alba to circumvent aggression. Foot shock induced aggression and water competition test were utilized as models for screening of antiaggressive activity. Eclipta alba significantly minimized dominance (p<0.05) which is correlated to the level of aggression particularly with 200mg/kg in the water competition test. A tangible behavioral submission was observed with 100 and 200mg/kg and of Eclipta alba in the foot shock induced test.
Lobo
Otilia J F
OJ
Department of Pharmacology, Siddaganga College of Pharmacy, Tumkur-572102, Karnataka.
Banji
David
D
Annamalai
A R
AR
Manavalan
R
R
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D036601:Eclipta; D004597:Electroshock; D008297:Male; D051379:Mice; D023421:Models, Animal; D018377:Neurotransmitter Agents / Q000502:physiology; D010146:Pain; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018377:Neurotransmitter Agents; D010936:Plant Extracts