[Association of CETP and CRP gene polymorphisms with non-valvular atrial fibrillation in Chinese Han population].
OBJECTIVE
To study whether the polymorphisms of TaqIB of cholesteryl transfer protein (CETP) gene and 1444C/T of C reactive protein (CRP) gene are associated with non-valvular atrial fibrillation in the Chinese Han population.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used to detect the distribution of genotypes of CETP TaqIB and CRP 1444C/T in 147 patients with non-valvular atrial fibrillation and 147 control subjects in Chinese Han population.


RESULTS
(1) The distribution of CETP TaqIB and CRP 1444C/T genotypes was in Hardy-Weinberg equilibrium. (2) A statistically significant difference between patients and controls for CETP TaqIB (P= 0.005, OR= 0.614, beta = -0.488) and CRP 1444C/T (P= 0.003, OR= 2.428, beta = 0.887) was observed. (3) In female group, significant difference was observed in smoking, CETP TaqIB and CRP 1444C/T polymorphisms. And in male group, significant difference was observed in body mass index and CETP TaqIB polymorphisms.


CONCLUSIONS
(1) These results suggest that CETP TaqIB (B2 allele as protective factor) and CRP1444C/T (T allele as risk factor) genetic polymorphisms may be associated with the non-valvular atrial fibrillation in the Chinese Han population. (2) Smoking and CRP1444T single nucleotide polymorphism may induce hereditary susceptibility to non-valvular atrial fibrillation in female. Obesity may induce hereditary susceptibility to non-valvular atrial fibrillation in male.
Yang
Wei-yu
WY
Department of Cardiovascular Medicine, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027 P. R. China.
Xu
Li-xin
LX
Zhang
Huai-qin
HQ
D000368:Aged; D044466:Asian People / Q000235:genetics; D001281:Atrial Fibrillation / Q000235:genetics*; D002097:C-Reactive Protein / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking
D053480:Cholesterol Ester Transfer Proteins; D002097:C-Reactive Protein