B cell development: important work for ERK.
The B cell receptor (BCR) activates the ERK kinases, but what does ERK do? In this issue of Immunity, Yasuda et al. (2008) show that ERK controls a transcription factor network by which the pre-BCR drives early B cell development.
Gold
Michael R
MR
Department of Microbiology and Immunology and I(3) and CELL Research Groups, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. mgold@interchange.ubc.ca
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000201:enzymology* / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000502:physiology*; D048052:Mitogen-Activated Protein Kinase 3 / Q000502:physiology*; D054420:Pre-B Cell Receptors / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology; D013234:Stem Cells / Q000166:cytology / Q000201:enzymology / Q000276:immunology
D054420:Pre-B Cell Receptors; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3