[A cohort study on parental history and risk factors of stroke in Chinese population].
OBJECTIVE
To assess the relationship between parental history and the incidence of stroke in Chinese populations.


METHODS
A total of 15,131 individuals (7015 men and 8116 women, aged from 35 to 59 years) in China were enrolled and followed up from 1992 to 2005. Information on the parental history of stroke of the participants was collected at baseline study under face to face interview. Individuals were divided into three groups according to their parental history of hypertension: those with no parental history of hypertension (Group 1), those with only one parent having the history of hypertension (Group 2) and those with both parents having the history of hypertension (Group 3). The hazard ratio and its 95% confidence interval were calculated using the Cox proportional hazard model.


RESULTS
There were 370 stroke events during 163 858 person-years of observation. After adjusting for age and sex, the hazard ratioon stroke for group 1, group 2 and group 3 were 1.00, 1.74 (1.33-2.29), 3.61 (1.86-7.01), respectively. After adjusting for age, sex, smoking, drinking, serum total cholesterol (TC), high density lipid cholesterol (HDL-C), fasting glucose, body mass index (BMI) and systolic blood pressure (SBP) in the model, the hazard ratio for stroke of those three groups were 1.00, 1.34 (1.02-1.77), 2.50 (1.29-4.87), respectively.


CONCLUSIONS
Individuals with parental history of stroke had a higher risk of stroke, and this was especially true for those with both parents having the history of stroke.
Zhang
Lin-feng
LF
Department of Epidemiology, Fu Wai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy Science, Beijing 100037, China.
Wu
Yang-feng
YF
Li
Ying
Y
Li
Xian
X
Xie
Gao-qiang
GQ
Zhao
Lian-cheng
LC
D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010290:Parents; D016016:Proportional Hazards Models; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*