Trans-endothelial and trans-epithelial transfer of lactoferrin into the brain through BBB and BCSFB in adult rats.
The transportation of intravenously administered bovine lactoferrin (bLF) into the cerebrospinal fluid (CSF) was immunohistochemically investigated in adult rats. Administered bLF was detected in the vesicular membranes of endothelial cells in cerebral blood vessels 10 min after the infusion. Numerous immunoreactive small vesicles were also detected at the ependymal cells in the choroid plexus. Moreover, the bLF concentration in the CSF was significantly increased at 1-2 hr after the intravenous infusion of bLF (10 or 30 mg/kg). These findings clearly demonstrate that LF is possibly transported into the brain matter even in adult animals.
Kamemori
Nao
N
Department of Veterinary Medicine, Tottori University, Tottori, Japan.
Takeuchi
Takashi
T
Sugiyama
Akihiko
A
Miyabayashi
Mariko
M
Kitagawa
Hiroshi
H
Shimizu
Hirohiko
H
Ando
Kunio
K
Harada
Etsumori
E
D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002831:Choroid Plexus / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D007150:Immunohistochemistry; D007781:Lactoferrin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D051381:Rats
D007781:Lactoferrin