title: Anticancer drugs and central nervous system: clinical issues for patients and physicians.
abstract: Anticancer drugs may cause neurological toxicity involving the central nervous system. Patients receiving anticancer treatment may develop encephalopathy, extrapyramidal reactions, seizures, cerebellar dysfunction, retinopathy, cerebral venous thrombosis, myelopathy, cognitive impairment, and psychiatric symptoms. Physician should carefully evaluate neurological signs and symptoms in order to recognize these drug-related adverse reactions. In this review we aimed at presenting different neurological complications of anticancer drugs and their management. PUBMED search was performed in order to retrieve all articles and case reports dealing with central nervous system toxicity related to anticancer treatments.
authors.affiliation: Department of Oncology, University and General Hospital of Udine, P.le SM della Misericordia, 33100 Udine, Italy. minisini.alessandro@aoud.sanita.fvg.it
authors.forename: Alessandro M
authors.initials: AM
authors.lastname: Minisini
authors.forename: Giada
authors.initials: G
authors.lastname: Pauletto
authors.forename: Claudia
authors.initials: C
authors.lastname: Andreetta
authors.forename: Paolo
authors.initials: P
authors.lastname: Bergonzi
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Fasola
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D003072:Cognition Disorders / Q000139:chemically induced; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced; D012164:Retinal Diseases / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents