Two new antibacterial norabietane diterpenoids from cyanobacteria, Microcoleous lacustris.
Two abietane diterpenes were isolated from cyanobacteria Microcoleous lacustris, 20-nor-3alpha-acetoxyabieta-5,7,9,11,13-pentaene and 20-nor-3alpha-acetoxy-12-hydroxy-abieta-5,7,9,11,13-pentaene. These compounds were assayed against Staphylococcus aureus, Staphylococcus epidermidis, Salmonella typhi, Vibrio cholerae, Bacillus subtilis, Bacillus cereus, Escherichia coli, and Klebsiella pneumoniae. Both compounds showed activity against S. aureus, S. epidermidis, S. typhi, and V. cholerae, but not against the other bacteria.
Pérez Gutiérrez
Rosa Martha
RM
Natural Products Research Laboratory, Industrias Extractivas (ESIQUIE)-IPN, Punto Fijo 16, Col. Torres Lindavista, C.P. 07708, Mexico DF, Mexico. rmpg@prodigy.net.mx
Martínez Flores
Amalia
A
Vargas Solís
Rosario
R
Carmona Jimenez
Javier
J
D045784:Abietanes / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D000458:Cyanobacteria / Q000737:chemistry*; D008826:Microbial Sensitivity Tests
C529866:20-nor-3alpha-acetoxy-12-hydroxy-abieta-5,7,9,11,13-pentaene; C529865:20-nor-3alpha-acetoxyabieta-5,7,9,11,13-pentaene; D045784:Abietanes; D000900:Anti-Bacterial Agents