title: Pyogranulomatous cystitis associated with Toxoplasma gondii infection in a cat after renal transplantation.
abstract: METHODS
  An 8-year-old spayed female domestic shorthair cat was evaluated for azotemia and a suspected mass in the urinary bladder 6 weeks after receiving a renal transplant. Ultrasonography revealed a mass at the ureteroneocystostomy site, and the mass was excised. Both the donor and recipient cats were seronegative for Toxoplasma gondii-specific IgG antibodies prior to transplantation.
  
  
  RESULTS
  Histologic evaluation of the mass revealed lesions indicative of extensive necrotizing pyogranulomatous cystitis with numerous intralesional T gondii tachyzoites and bradyzoite cysts.
  
  
  RESULTS
  Treatment with clindamycin was initiated; however, the cat's clinical condition continued to decline, and it was euthanized 9 days after the mass was excised. Necropsy revealed T gondii cysts within the renal allograft and the transplanted ureter, with no evidence of systemic spread of organisms.
  
  
  CONCLUSIONS
  Toxoplasmosis should be considered as a differential diagnosis for azotemia in feline renal transplant recipients regardless of the results of assays for T gondii antibodies in the serum of donors or recipients. This report illustrated the need for improved screening of donor and recipient cats and the importance of minimizing exposure to potential sources of T gondii after transplantation.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Barbro C
authors.initials: BC
authors.lastname: Nordquist
authors.forename: Lillian R
authors.initials: LR
authors.lastname: Aronson
mesh_terms: D000818:Animals; D053099:Azotemia / Q000209:etiology / Q000662:veterinary; D002415:Cats; D003556:Cystitis / Q000175:diagnosis / Q000469:parasitology / Q000662:veterinary; D017809:Fatal Outcome; D005260:Female; D007668:Kidney / Q000469:parasitology*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000662:veterinary*; D014019:Tissue Donors; D014122:Toxoplasma / Q000302:isolation & purification*; D014124:Toxoplasmosis, Animal / Q000150:complications / Q000175:diagnosis* / Q000635:transmission