title: Renal cell carcinoma with sarcomatoid features and peritumoral sarcoid-like granulomatous reaction: report of a case and review of the literature.
abstract: Granulomatous inflammation with multinucleated giant cells is observed in various infectious and noninfectious diseases. It has been found in association with malignant tumors and designated sarcoid-like reaction. The distinction between a tumor-related granulomatous reaction and a true sarcoidosis can be a problematic issue. A case of renal cell carcinoma with sarcomatoid features (Fuhrman nuclear grade IV) with an extensive peritumoral sarcoid-like reaction and a critical review of the few cases of this association described in the literature have been reported, and the problematic clinical and pathological assessments of such lesions are discussed.
authors.affiliation: Department of Radiology, Civil Hospital of Budrio, Rome, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Piscioli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Donato
authors.forename: Luca
authors.initials: L
authors.lastname: Morelli
authors.forename: Franca
authors.initials: F
authors.lastname: Del Nonno
authors.forename: Stefano
authors.initials: S
authors.lastname: Licci
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000473:pathology; D003950:Diagnostic Techniques, Urological; D017809:Fatal Outcome; D006099:Granuloma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D012507:Sarcoidosis / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000473:pathology* / Q000601:surgery