title: Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication.
abstract: Hemodialysis is only infrequently used in drug overdosage situations. The efficacy of hemodialysis to remove the drug depends upon the pharmacokinetics and pharmacodynamics of the drug. At normal therapeutic concentrations, valproic acid is predominantly protein bound and therefore removal by hemodialysis is limited. In an overdose situation, protein binding is rapidly saturated and therefore the substantially larger quantities of the free drug can rapidly cause toxicity. Slow low-efficient daily diafiltration (SLEDD) has not previously been utilized in a drug overdose situation. We report the effective use of SLEDD to remove high toxic concentrations of valproic acid in an overdose situation. Slow low-efficient daily diafiltration also prevented the rebound phenomenon that can occur as the excess drug is released from its protein-bound stores. Hybrid dialysis therapies deserve further evaluation in the management of other poisonings where extra-corporeal therapy is indicated.
authors.affiliation: Department of Nephrology Dunedin Hospital, Dunedin, New Zealand.
authors.forename: Emon
authors.initials: E
authors.lastname: Khan
authors.forename: Paul
authors.initials: P
authors.lastname: Huggan
authors.forename: Leo
authors.initials: L
authors.lastname: Celi
authors.forename: Robert
authors.initials: R
authors.lastname: MacGinley
authors.forename: John
authors.initials: J
authors.lastname: Schollum
authors.forename: Robert
authors.initials: R
authors.lastname: Walker
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000097:blood / Q000506:poisoning*; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D062787:Drug Overdose; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D014635:Valproic Acid / Q000097:blood / Q000506:poisoning*
chemical_list: D018692:Antimanic Agents; D014635:Valproic Acid