[A case of lumbar metastases from rectal cancer successfully treated by UFT plus oral leucovorin (LV) therapy].
A 63-year-old man had undergone a low anterior resection for rectal cancer with multiple liver metastases. Oral UFT (450 mg/day) administration alone was started after the operation. After 6 months post operatively, the patient was diagnosed as anastomosis recurrence because of ileus by abdominal X-ray. Transverse loop colostomy was performed by emergency surgery. After surgery, he suffered from paraplegia for lumbar vertebrae metastases. UFT+LV therapy was started. After chemotherapy a significant reduction of the lymph node and liver metastases and an apparent decrease in CEA and CA19-9 were observed. The patient left the hospital and showed no signs of tumor exacerbation for three months. The patient died of aggravation of primary disease afterwards. The therapy was safe and effective, and has successfully maintained the quality of life (QOL) of this patient.
Suzumura
Kazuyoshi
K
Department of Surgery, Division of Gastrointestinal Surgery, Aichi Medical University School of Medicine.
Ito
Nobuhiro
N
Nagata
Hiroshi
H
Kotake
Katsuhiro
K
Arikawa
Takashi
T
Ando
Keiichi
K
Nakao
Noiku
N
Kurokawa
Tsuyoshi
T
An
Jun
J
Nonami
Toshiaki
T
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D014498:Uracil / Q000627:therapeutic use
D014408:Biomarkers, Tumor; D005641:Tegafur; D014498:Uracil; D002955:Leucovorin