Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy.
An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.
Lautz
T B
TB
Department of Surgery, Children's Memorial Hospital, Feinberg School of Medicine of Northwestern University, Chicago, IL 60614, USA.
Finegold
M J
MJ
Chin
A C
AC
Superina
R A
RA
D018248:Adenoma, Liver Cell / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D001706:Biopsy; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D000078330:Oxcarbazepine; D012640:Seizures / Q000188:drug therapy; D016896:Treatment Outcome
D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine