title: The association of peripheral arterial occlusive disease with major coronary events in a mediterranean population with low coronary heart disease incidence.
abstract: OBJECTIVE
  The association of peripheral arterial occlusive disease (PAD) association with major coronary events (MCE) has been well documented, nevertheless data are lacking for populations with a low incidence of coronary heart disease (CHD). We aimed to assess the association of PAD with MCE in a Mediterranean population.
  
  
  METHODS
  Prospective survey of 699 55-74 year-old men representative of an urban district near Barcelona (Spain).
  
  
  METHODS
  Baseline cardiovascular risk factors, CHD and PAD (ankle/brachial index<0.9) were recorded. MCE were evaluated during the 5-year follow-up.
  
  
  RESULTS
  At recruitment 94 subjects (13.4%) had PAD. During follow-up (mean 69.3 months), 35 (5%) subjects suffered a MCE, of whom 12 had PAD, 9 previous symptomatic CHD and 1 subject both conditions. Higher CHD related mortality (8.6% vs 1.4%; p<0.001) and lower MCE-free survival (78.67% vs 93.26%; p<0.001) was observed for PAD subjects. On Cox regression analysis PAD (RR=3; p=0.003) and previous symptomatic CHD (RR=4.1; p<0.001) were associated independently with MCE during follow-up.
  
  
  CONCLUSIONS
  Even in a population with a low incidence of CHD there is a strong relationship between PAD and future MCE. Screening for PAD may improve the selection of patients targeted for cardiovascular risk prevention.
authors.affiliation: Angiology and Vascular Surgery, Hospital del Mar, Universidad Autonoma Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Merino
authors.forename: A
authors.initials: A
authors.lastname: Planas
authors.forename: A
authors.initials: A
authors.lastname: De Moner
authors.forename: A
authors.initials: A
authors.lastname: Gasol
authors.forename: C
authors.initials: C
authors.lastname: Contreras
authors.forename: J
authors.initials: J
authors.lastname: Marrugat
authors.forename: F
authors.initials: F
authors.lastname: Vidal-Barraquer
authors.forename: A
authors.initials: A
authors.lastname: Clarà
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000401:mortality; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D003327:Coronary Disease / Q000150:complications* / Q000401:mortality / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications* / Q000401:mortality; D011159:Population Surveillance; D015995:Prevalence; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors