Primary hepatic lymphoma of mucosa-associated lymphoid tissue type: a case report with cytogenetic study.
Primary hepatic lymphoma of mucosa-associated lymphoid tissue type is extremely rare. Only 38 cases have been reported to date. A case of a 59-year-old man with Helicobacter pylori-resistant gastric ulcers and Buerger disease who was followed up since 1999 is reported. A 2-cm hepatic nodule was incidentally found during partial gastrectomy and corresponded to mucosa-associated lymphoid tissue-type lymphoma without underlying liver disease. Molecular studies showed a clonal immunoglobulin heavy-chain gene rearrangement. Investigations for the mucosa-associated lymphoid tissue lymphoma-associated translocations t(11;18) and t(14;18), as well as the t(3;14)(q27;q32), were negative, whereas trisomy 3 and trisomy 18 were detected.
Koubaa Mahjoub
Wafa
W
Département de Pathologie, Assistance Publique-Hôpitaux de Paris, Groupe Henri Mondor-Albert Chenevier, Créteil, France.
Chaumette-Planckaert
Marie-Therese
MT
Murga Penas
Eva Maria
EM
Dierlamm
Judith
J
Leroy
Karen
K
Delfau
Marie-Helene
MH
Loriau
Jerome
J
Gaulard
Philippe
P
Delchier
Jean-Charles
JC
Zafrani
Elie-Serge
ES
Copie-Bergman
Christiane
C
D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D018572:Disease-Free Survival; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014314:Trisomy