Role of hypaphorine in the toxicity of Astragalus lusitanicus.
Hypaphorine, an alpha-N,N,N-trimethyltryptophan betaine, was isolated, for the first time, from Astragalus lusitanicus Lam. (Fabaceae), a plant highly toxic for lambs and goats. This alkaloid was characterized by NMR and MS analysis. Hypaphorine was previously reported to be a convulsive poison. To confirm the toxicity, it was synthesized and tested in goats. Hypaphorine was shown to be non-toxic for goats even at a high dose of 2 g kg(-1) by oral administration.
Bel-Kassaoui
Hakima
H
Département de Pharmacie Toxicologie et Biochimie, Institut Agronomique et Vétérinaire Hassan II BP 6202, Rabat-Instituts, Morocco.
Lamnaouer
Driss
D
Jossang
Akino
A
Abdennebi
El Hassane
el H
Charrouf
Zoubida
Z
Bodo
Bernard
B
D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry*; D001681:Biological Assay; D006041:Goats; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D010947:Plants, Toxic / Q000737:chemistry*
D007211:Indoles; D010936:Plant Extracts; C001529:lenticin