title: Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds.
abstract: A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.
authors.affiliation: Novartis Animal Health Inc., Chemistry and Bioactives, Schwarzwaldallee 215, CH-4002 Basel, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Ducray
authors.forename: Noëlle
authors.initials: N
authors.lastname: Gauvry
authors.forename: François
authors.initials: F
authors.lastname: Pautrat
authors.forename: Thomas
authors.initials: T
authors.lastname: Goebel
authors.forename: Joerg
authors.initials: J
authors.lastname: Fruechtel
authors.forename: Yves
authors.initials: Y
authors.lastname: Desaules
authors.forename: Sandra Schorderet
authors.initials: SS
authors.lastname: Weber
authors.forename: Jacques
authors.initials: J
authors.lastname: Bouvier
authors.forename: Trixie
authors.initials: T
authors.lastname: Wagner
authors.forename: Olivier
authors.initials: O
authors.lastname: Froelich
authors.forename: Ronald
authors.initials: R
authors.lastname: Kaminsky
mesh_terms: D000607:Aminoacetonitrile / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006189:Haemonchus / Q000187:drug effects*; D008956:Models, Chemical; D021261:Parasitic Sensitivity Tests; D013329:Structure-Activity Relationship; D014254:Trichostrongylus / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D000607:Aminoacetonitrile