Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection.
In the past 25 years, life survival curves of many countries have been remodeled owing to HIV infection. Both HIV-1 and HIV-2 can cause AIDS, yet patients infected with HIV-2 fare much better clinically and most will never experience detrimental effects of the infection. Despite over two decades of comprehensive research into vaccine development, a prophylactic vaccine is not yet realized. An essential missing link in the innovation of a successful vaccine strategy is the description of a favorable immune response that abolishes virus replication. Lessons learned from studying the role of the immune system in the long-term nonprogression characteristic of HIV-2 infection will offer insight into how a balanced immune response can protect from the destruction of the immune system associated with chronic HIV-1 infection.
Leligdowicz
Aleksandra
A
Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia, West Africa. srowland-jones@mrc.gm
Rowland-Jones
Sarah
S
D016915:AIDS Vaccines / Q000627:therapeutic use; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D000818:Animals; D018450:Disease Progression; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D015498:HIV-2 / Q000276:immunology*; D006801:Humans
D016915:AIDS Vaccines