Successful treatment of disseminated Geotrichum capitatum infection with a combination of caspofungin and voriconazole in an immunocompromised patient.
Disseminated Geotrichum capitatum infection is uncommon, and has been reported exclusively in immunocompromised patients. The prognosis is poor with a mortality rate of approximately 50-75%. We report a case of disseminated G. capitatum infection in a severely neutropenic patient who was receiving chemotherapy for acute myeloblastic leukaemia. G. capitatum was isolated from blood cultures, skin lesions, bronchoalveolar lavage fluid, throat swabs and stools. The infection was successfully cured with a combination of voriconazole and caspofungin.
Etienne
A
A
Service d'Hématologie, Hôpital Pitié Salpêtrière, Paris, France.
Datry
A
A
Gaspar
N
N
Morel
V
V
Delabesse
E
E
Lmimouni
B
B
Vernant
J P
JP
Dhédin
N
N
D000935:Antifungal Agents / Q000627:therapeutic use; D000077336:Caspofungin; D004338:Drug Combinations; D054714:Echinocandins / Q000627:therapeutic use*; D005847:Geotrichosis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D005848:Geotrichum / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole