A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart.
Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. In addition, the characteristic increase in taurine associated with dystrophic tissue is correlated with proteins associated with oxidative phosphorylation and mitochondrial metabolism.
Gulston
Melanie K
MK
The Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.
Rubtsov
Denis V
DV
Atherton
Helen J
HJ
Clarke
Kieran
K
Davies
Kay E
KE
Lilley
Kathryn S
KS
Griffin
Julian L
JL
D000375:Aging / Q000502:physiology; D000818:Animals; D016189:Dystrophin / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008660:Metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx / Q000033:anatomy & histology / Q000378:metabolism; D020388:Muscular Dystrophy, Duchenne / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010363:Pattern Recognition, Automated; D020543:Proteome / Q000032:analysis; D040901:Proteomics; D013654:Taurine / Q000378:metabolism
D016189:Dystrophin; D020543:Proteome; D013654:Taurine