TAFI antigen level variability in young healthy Asian Indians; first report from Asia.
Thrombin Activatable Fibrinolytic Inhibitor (TAFI) is a plasma protein, which inhibits fibrinolysis by removing carboxyterminal lysine residues from partially degraded fibrin thereby decreasing plasminogen binding on its surface. In this study we have investigated the antigenic level variability (Inter and Intraindividual) of Thrombin Activatable Fibrinolysis Inhibitor in 120 healthy Asian Indians since no data on this is available regarding this population. TAFI antigen levels did not show a normal distribution in our population (p<0.001). Median TAFI antigen levels were found to be 11.683 microg/ml. It ranged from 33.9-202.5%of normal pool plasma (3.9-23.5 microg/ml). TAFI antigenic level showed high level of variability in the Indian population (coefficient of variation: 37.4%). TAFI antigenic levels were stable intraindividually (p=0.218).
Biswas
Arijit
A
Department of Hematology, AIIMS, New Delhi, India.
Ranjan
Ravi
R
Meena
Arvind
A
Akhter
Suhail
S
Saut
Noemie
N
Frere
Corinne
C
Vague
Irene Juhan
IJ
Shukla
Deepak Kumar
DK
Behari
Madhuri
M
Saxena
Renu
R
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D025901:Carboxypeptidase B2 / Q000097:blood* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007194:India; D008297:Male
D025901:Carboxypeptidase B2