Long-term treatment with buprenorphine/naloxone in primary care: results at 2-5 years.
To examine long-term outcomes with primary care office-based buprenorphine/naloxone treatment, we followed 53 opioid-dependent patients who had already demonstrated six months of documented clinical stability for 2-5 years. Primary outcomes were retention, illicit drug use, dose, satisfaction, serum transaminases, and adverse events. Thirty-eight percent of enrolled subjects were retained for two years. Ninety-one percent of urine samples had no evidence of opioid use, and patient satisfaction was high. Serum transaminases remained stable from baseline. No serious adverse events related to treatment occurred. We conclude that select opioid-dependent patients exhibit moderate levels of retention in primary care office-based treatment.
Fiellin
David A
DA
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8025, USA. david.fiellin@yale.edu
Moore
Brent A
BA
Sullivan
Lynn E
LE
Becker
William C
WC
Pantalon
Michael V
MV
Chawarski
Marek C
MC
Barry
Declan T
DT
O'Connor
Patrick G
PG
Schottenfeld
Richard S
RS
D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D003376:Counseling; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006556:Heroin Dependence / Q000453:epidemiology / Q000534:rehabilitation*; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage* / Q000009:adverse effects; D009292:Narcotic Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D009293:Opioid-Related Disorders / Q000453:epidemiology / Q000534:rehabilitation*; D010352:Patient Dropouts / Q000706:statistics & numerical data; D011320:Primary Health Care / Q000706:statistics & numerical data; D015813:Substance Abuse Detection / Q000706:statistics & numerical data; D016896:Treatment Outcome
D009292:Narcotic Antagonists; D009270:Naloxone; D002047:Buprenorphine