[Study on an injectable biomimetic hydroxyapatite--atelocollagen composite].
The paper presents a procedure for preparing mineralized collagen nanofibrils, mixed with deficient nanoparticulate calcium hydroxyapatite in a ratio close to that found in living bone structures. Such a composition might represent an injectable osteoconductive constituent, used in surgical kits for bone reconstruction. The FT-IR spectra of the prepared composite reveals a weak absorption at 871.82 cm(-1), indicating the nucleation of hydroxy-apatite at the acidic atelocollagen functions. More than that, a 45 cm(-1) ipsochromic shift of carboxylic band suggest a strong ionic interaction with hydroxyapatite. The X-Ray spectra show a high resemblance between the synthetic composite and the Fluka hydroxyapatite, but only for 2theta angles higher than 30 degrees. Below that value the protein presence induce crystalline disorders.
Maier
S S
SS
Universitatea Tehnică "Gh. Asachi" din Iaşi.
Pelin
Irina
I
Bulacovschi
V
V
D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage / Q000138:chemical synthesis*; D004337:Drug Carriers / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D007267:Injections; D019736:Prostheses and Implants; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
D001672:Biocompatible Materials; D018786:Bone Substitutes; D004337:Drug Carriers; C059821:atelocollagen; D003094:Collagen; D017886:Durapatite