Polysaccharides fraction isolated from ginkgo biloba folium: immunopharmacological properties.
Many macromolecular compounds of vegetal polysaccharides type develop important immunostimulatory properties.


METHODS
Crude macromolecular fraction was isolated from the leaves of Ginkgo biloba L. (codified as PGfol) harvested from Botanical Gardens of Iaşi, Romania. The hot water extract was partially purified and submitted to chemical and immunopharmacological studies. The immunostimulatory activity of PGfol was further investigated by a series of tests on rats: phagocytosis capacity of PMN cells by NBT test, serum complement activity and determination of the activity of splenic T-lymphocytes.


RESULTS
PGfol has a good immunostimulatory activity which is equal or higher to Levamisole (positive control).
Hăncianu
Monica
M
Department of Pharmacognosy, School of Pharmacy, "Gr.T. Popa" University of Medicine and Pharmacy, Iaşi.
Pavelescuz
M
M
Miron
Anca
A
Aprotosoaie
Ana Clara
AC
Grigorescu
Em
E
Lupuşoru
Cătălina
C
Stănescu
Ursula
U
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D020441:Ginkgo biloba / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use; D010587:Phagocytosis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D011134:Polysaccharides; D007978:Levamisole