title: Collaborative engineering: 3-D optical imaging and gas exchange simulation of in-vitro alveolar constructs.
abstract: This paper reports on the computational simulation and modeling of an in vitro alveolar construct system along the optical coherence microscopy (OCM) methods for visualizing engineered tissue. The optical imaging methods will be compared to immunohistochemical light microscopy samples of engineered alveolar constructs. Results show depth images of the alveolar tissue construct for a bilayer construct, as well as predictions of the gas exchange process in a simple model of a bio-reactor hosting the construct.
authors.affiliation: CREOL, College of Optics and Photonics, University of Central Florida, Orlando, FL 32816, USA.
authors.forename: Jannick P
authors.initials: JP
authors.lastname: Rolland
authors.forename: Kye-Sung
authors.initials: KS
authors.lastname: Lee
authors.forename: Ayesha
authors.initials: A
authors.lastname: Mahmood
authors.forename: Lisa
authors.initials: L
authors.lastname: Fluck
authors.forename: Jaime
authors.initials: J
authors.lastname: Duarte
authors.forename: Ilhan
authors.initials: I
authors.lastname: Kaya
authors.forename: Anand
authors.initials: A
authors.lastname: Santhanam
authors.forename: Panomsak
authors.initials: P
authors.lastname: Meemon
authors.forename: Supraja
authors.initials: S
authors.lastname: Murali
authors.forename: Olusegun
authors.initials: O
authors.lastname: Ilegbusi
authors.forename: Patrick
authors.initials: P
authors.lastname: Kupelian
authors.forename: William L
authors.initials: WL
authors.lastname: Warren
authors.forename: Peter
authors.initials: P
authors.lastname: Molnar
authors.forename: James
authors.initials: J
authors.lastname: Hickman
authors.forename: Papachan
authors.initials: P
authors.lastname: Kolattukudy
mesh_terms: D003198:Computer Simulation; D003299:Cooperative Behavior; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008853:Microscopy; D011659:Pulmonary Gas Exchange; D023822:Tissue Engineering; D041623:Tomography, Optical Coherence; D014481:United States