Aging of the immune system as a prognostic factor for human longevity.
Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.
Larbi
Anis
A
University of Tübingen, Center for Medical Research,Tübingen, Germany. anis.larbi@medizin.uni-tuebingen.de
Franceschi
Claudio
C
Mazzatti
Dawn
D
Solana
Rafael
R
Wikby
Anders
A
Pawelec
Graham
G
D000375:Aging / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008136:Longevity / Q000276:immunology*; D011379:Prognosis