Inclusion or exclusion of intratumoral vessels in relative cerebral blood volume characterization in low-grade gliomas: does it make a difference?
We assessed the influence of inclusion (method 1) and exclusion (method 2) of intratumoral vessels when determining maximum relative cerebral blood volume (rCBVmax) in 3 types of low-grade gliomas (LGGs): astrocytomas, oligoastrocytomas, and oligodendrogliomas. Method 1 yielded significantly higher mean rCBVmax than method 2. However, only method 2 demonstrated a significant (P = .026) association between rCBVmax and membership of a differently ranked histologic category. Exclusion of intratumoral vessels appears, therefore, preferable when determining rCBVmax in LGGs.
Caseiras
G Brasil
GB
Lysholm Department of Neuroradiology, University College London, London, United Kingdom. g.brasil@ion.ucl.ac.uk
Thornton
J S
JS
Yousry
T
T
Benton
C
C
Rees
J
J
Waldman
A D
AD
Jäger
H R
HR
D001810:Blood Volume; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology*; D002560:Cerebrovascular Circulation; D005910:Glioma / Q000098:blood supply* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity