Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report.
We present a case of severe mucositis due to a drug-drug interaction between methotrexate (MTX) and omeprazole in an adolescent with Acute Lymphatic Leukemia (ALL). In view of the prevalence of MTX in many cytotoxic protocols, and the frequent use of omeprazole in the (ambulatory) oncology setting, we believe that this case-report is worth mentioning.
Bauters
Tiene G M
TG
Department of Pharmacy, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. tiene.bauters@uzgent.be
Verlooy
Joris
J
Robays
Hugo
H
Laureys
Geneviéve
G
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use*; D009853:Omeprazole / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000964:Antimetabolites, Antineoplastic; D011899:Ranitidine; D011239:Prednisolone; D009853:Omeprazole; D008727:Methotrexate