title: Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings.
abstract: The authors report the case of a female patient who developed chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin for prophylaxis of recurrent urinary tract infections due to urethral stenosis. On high-resolution computed tomography scans, the pulmonary reaction to nitrofurantoin most commonly manifests as an interstitial-alveolar pattern in both lung bases. However, in this case, the alterations were most pronounced in the periphery of the upper lobes. In itself, this tomographic profile is strongly indicative of chronic eosinophilic pneumonia. The patient had previously been submitted to an open lung biopsy. The diagnosis of chronic eosinophilic pneumonia was confirmed through a review of the biopsy.
authors.affiliation: Armed Forces Hospital - Brasília, Brazil. sanemar@correioweb.com.br
authors.forename: Rosane Rodrigues
authors.initials: RR
authors.lastname: Martins
authors.forename: Edson
authors.initials: E
authors.lastname: Marchiori
authors.forename: Sérgio Lopes
authors.initials: SL
authors.lastname: Viana
authors.forename: Luiz Sérgio Pereira
authors.initials: LS
authors.lastname: Grillo Júnior
authors.forename: Vera Luiza
authors.initials: VL
authors.lastname: Capelozzi
authors.forename: Laércio Moreira
authors.initials: LM
authors.lastname: Valença
mesh_terms: D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D009582:Nitrofurantoin / Q000009:adverse effects*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D014552:Urinary Tract Infections / Q000517:prevention & control
chemical_list: D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin