A new peritoneal carcinomatosis model in cyclosporine immunosuppressed rats.
Colorectal cancer (CRC) cells (HT29) were injected into the intraperitoneal (i.p.) cavity of immunosuppressed male Sprague Dawley rats. Immunosuppression was achieved via a daily i.p. injection of cyclosporine 35 mg/kg/day. Three groups of rats (n = 6 per group) were injected with 20, 50 or 100 million HT29 cells. All animals developed tumours indicating that this animal model may prove useful for future research in human colorectal carcinomatosis.
Akhter
Javed
J
University of New South Wales, Department of Surgery, St. George Hospital, Sydney, Australia.
Yao
Peng
P
Johnson
Loreena A
LA
Riordan
Steve M
SM
Morris
David L
DL
D000818:Animals; D048708:Cell Growth Processes / Q000276:immunology; D015179:Colorectal Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology; D016572:Cyclosporine / Q000097:blood / Q000494:pharmacology*; D004195:Disease Models, Animal; D019073:HT29 Cells; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009361:Neoplasm Invasiveness; D010534:Peritoneal Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D007166:Immunosuppressive Agents; D016572:Cyclosporine