title: The Bordetella type III secretion system: its application to vaccine development.
abstract: B. pertussis is a causative agent of whooping cough (pertussis) in humans. Despite wide-scale vaccination in many countries, there is serious concern about pertussis as a re-emerging disease. Re-emergence of pertussis may be explained by several factors: the short duration of protection by the currently available acellular pertussis vaccine, an increase in asymptomatic adult carriers and expansion of strains with certain antigenic variations which are not covered by currently available vaccines. To develop safer and more efficacious vaccines which confer more prolonged protection, researchers are focusing on identification and characterization of new virulence factors. One candidate for protective antigens is the type III secretion system and its secreted proteins.
authors.affiliation: Laboratory of Bacterial Infection, Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, Tokyo, Japan. abe@lisci.kitasato-u.ac.jp
authors.forename: Akio
authors.initials: A
authors.lastname: Abe
authors.forename: Kanna
authors.initials: K
authors.lastname: Nagamatsu
authors.forename: Mineo
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology*; D001886:Bordetella pertussis / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D010567:Pertussis Vaccine / Q000276:immunology; D037521:Virulence Factors / Q000502:physiology*; D014917:Whooping Cough / Q000453:epidemiology
chemical_list: D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D010567:Pertussis Vaccine; D037521:Virulence Factors