title: A new single nucleotide polymorphism in XRCC4 gene is associated with breast cancer susceptibility in Taiwanese patients.
abstract: BACKGROUND
  The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. Some new and important polymorphic variants of XRCC4, at codon 247 (rs 3734091), G-1394T (rs 6869366), and Intron 7 (rs 28360317), and their association with breast cancer susceptibility was investigated in a Taiwanese population.
  
  
  METHODS
  In a hospital-based case-control study, 432 female patients with breast cancer and 432 age-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped.
  
  
  RESULTS
  A significant difference in the frequency of the XRCC4 G-1394T genotype, but not the XRCC4 codon 247, or intron 7 genotypes was found between the breast cancer and control groups. Individuals with G/T or T/T at the XRCC4 G-1394T locus showed a 2.33-fold (95% confidence interval=1.37-3.98) increased risk of breast cancer compared to those with G/G. For XRCC4 codon 247 or intron 7, there was no difference in distribution between the breast cancer and control groups.
  
  
  CONCLUSIONS
  Our findings suggest that the heterozygous and homozygous T allele of the XRCC4 G-1394T may be associated with the development of breast cancer and may be a useful biomarker for anticancer prevention and intervention.
authors.affiliation: Department of Hematology Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chang-Fang
authors.initials: CF
authors.lastname: Chiu
authors.forename: Hwei-Chung
authors.initials: HC
authors.lastname: Wang
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Wang
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Wang
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Shen
authors.forename: Su-Yin
authors.initials: SY
authors.lastname: Chiang
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan
chemical_list: D004268:DNA-Binding Proteins; C101467:XRCC4 protein, human