Antiphospholipid antibodies and acute-phase response in non-metastatic colorectal cancer patients.
OBJECTIVE
To investigate the plasma levels and prevalence of the most common antiphospholipid antibodies, as well as their relationships with several plasma markers of inflammation, in order to characterize some aspects of cancer thrombophilia.


METHODS
Eighty-three cancer patients with non-metastatic colorectal solid tumors and 94 control subjects were tested for the presence of IgG/IgM/IgA anti-cardiolipin and anti-Beta2-glycoprotein I antibodies and of several acute-phase reactants, i.e., fibrinogen, factor VIII:C and C4b-binding protein.


RESULTS
In cancer patients the plasma levels of the acute-phase reactants and the IgA/IgG anti-cardiolipin and IgA anti-Beta2- glycoprotein I antibodies were significantly higher; the acute-phase reactants were significantly correlated with anti-cardiolipin antibodies; the prevalence of antiphospholipid antibodies was not significantly higher.


CONCLUSIONS
In patients with non-metastatic colorectal cancer the acute-phase response is associated with antiphospholipid generation. This could represent a further pathogenetic mechanism for the short-term post-surgery thrombotic complications of patients with colorectal cancer.
Battistelli
S
S
Department of General Surgery, Policlinico Le Scotte, Siena - Italy. battistelli@unisi.it
Stefanoni
M
M
Petrioli
R
R
Genovese
A
A
Dell'avanzato
R
R
Donati
G
G
Vittoria
A
A
Roviello
F
F
D000209:Acute-Phase Proteins / Q000378:metabolism; D000210:Acute-Phase Reaction / Q000097:blood* / Q000209:etiology; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000150:complications / Q000276:immunology*; D050716:Complement C4b-Binding Protein; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006649:Histocompatibility Antigens / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D013927:Thrombosis / Q000209:etiology; D053482:beta 2-Glycoprotein I / Q000276:immunology
D000209:Acute-Phase Proteins; D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; C055609:C4BPA protein, human; D050716:Complement C4b-Binding Protein; D006649:Histocompatibility Antigens; D053482:beta 2-Glycoprotein I; D005169:Factor VIII; D005340:Fibrinogen