Lives of a heart cell: tracing the origins of cardiac progenitors.
Heart cells are the unitary elements that define cardiac function and disease. The recent identification of distinct families of cardiovascular progenitor cells begins to build a foundation for our understanding of the developmental logic of human cardiovascular disease, and also points to new approaches to arrest and/or reverse its progression, a major goal of regenerative medicine. In this review, we highlight recent clarifications, revisions, and advances in our understanding of the many lives of a heart cell, with a primary focus on the emerging links between cardiogenesis and heart stem cell biology.
Martin-Puig
Silvia
S
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114-2790, USA.
Wang
Zhong
Z
Chien
Kenneth R
KR
D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology*