title: [Factors related to the length of the corrected QT interval in patients treated with antipsychotics].
abstract: OBJECTIVE
  The length of the heart-rate corrected QT interval (QTc) has been associated with an increased risk of cardiac dysrhythmia and sudden death. QTc length has been related to age, obesity, poor glycemic control, and use of drugs, such as antipsychotic medications. The objective of this cross-sectional naturalistic study was to assess the factors associated with QTc length in patients treated with antipsychotics.
  
  
  METHODS
  Bazett's formula for heart-rate correction was used to compute the corrected QT in 195 psychiatric inpatients treated with antipsychotics -117 males (60.0%), 78 females (40.0%); age (standard deviation): 28.4 (17.3) years (range: 12-84)-.
  
  
  RESULTS
  Older age (p < 0.001) and female gender (p = 0.006) were the only factors significantly related to longer QTc interval. Diagnosis, type of antipsychotic, dosage of antipsychotic, tobacco use, and cardiovascular history were not related to QTc length. Only one male patient with QTc = 455 had a pathological QTc length (females > 470 ms, males > 450 ms).
  
  
  CONCLUSIONS
  Factors related to QTc length in patients treated with antipsychotics are equivalent to those found in previous studies in patients not treated with antipsychotics.
authors.affiliation: Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, Madrid, España. davidfraguas@hggm.es
authors.forename: David
authors.initials: D
authors.lastname: Fraguas Herráez
authors.forename: Paula
authors.initials: P
authors.lastname: Laita de Roda
authors.forename: Guillermo
authors.initials: G
authors.lastname: González Balmaseda
authors.forename: Eugenia
authors.initials: E
authors.lastname: González Laynez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Gamo Bravo
authors.forename: David
authors.initials: D
authors.lastname: Pascual Hernández
authors.forename: Mara
authors.initials: M
authors.lastname: Parellada Redondo
authors.forename: Dolores
authors.initials: D
authors.lastname: Moreno Pardillo
authors.forename: Carolina
authors.initials: C
authors.lastname: Franco Porras
authors.forename: Cloe
authors.initials: C
authors.lastname: Llorente Sarabia
authors.forename: Steven A
authors.initials: SA
authors.lastname: Kushner
authors.forename: Celso
authors.initials: C
authors.lastname: Arango López
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004452:Echocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents