Conformer independent heterodimerisation of linear arrays using three hydrogen bonds.
5-Membered heterocycles are employed to give a conformer independent DDA array of hydrogen bonds, resulting in enhanced binding affinity to a complementary AAD array in comparison to a DDA array employing a 6-membered ring.
McGhee
Andrea M
AM
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK.
Kilner
Colin
C
Wilson
Andrew J
AJ
D018360:Crystallography, X-Ray; D019281:Dimerization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D006576:Heterocyclic Compounds, 4 or More Rings