Enteric infections, diarrhea, and their impact on function and development.
Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration caused by infection with an enteric pathogen, but it has not changed the morbidity caused by such infections. This Review focuses on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development. We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding.
Petri
William A
WA
Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Miller
Mark
M
Binder
Henry J
HJ
Levine
Myron M
MM
Dillingham
Rebecca
R
Guerrant
Richard L
RL
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D015415:Biomarkers; D003967:Diarrhea / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology / Q000503:physiopathology*; D004198:Disease Susceptibility; D004751:Enteritis / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans
D001428:Bacterial Vaccines; D015415:Biomarkers