title: Anterior ischemic optic neuropathy due to giant cell arteritis with normal inflammatory markers.
abstract: BACKGROUND
  In anterior ischemic optic neuropathy (AION), it is important not to miss the diagnosis of giant cell arteritis (GCA) because this requires immediate steroid treatment to prevent involvement of the second eye and possible blindness. A missed diagnosis also might lead to fatal systemic complications.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 79-year-old woman noticed decreased visual and visual field loss in the right eye. At presentation, right visual acuity was 10/20 (ETDRS chart 2000). There was a right relative afferent pupillary defect of 0.6 log units. Asked for symptoms of GCA she complained about temporal and occipital headache, jaw claudication combined with malaise, and myalgia of the upper limbs. Laboratory tests showed normal inflammatory markers. Repeated tests confirmed ESR and CRP to be within the normal range. GCA being suspected, ultrasound of the superficial temporal arteries and temporal artery biopsy were performed unilaterally on the right side. Histology showed a chronic inflammatory cell infiltrate consistent with active GCA. The patient was treated with high-dose corticosteroids (250 mg methylprednisolone, three times/day, initially) and symptoms rapidly resolved, but visual loss remained unchanged.
  
  
  CONCLUSIONS
  The case presented here proves that GCA with typical related visual loss (AION) is possible even when both ESR and CRP are in the normal range. Therefore, in the presence of typical symptoms, the clinician must not rely solely on laboratory testing, but start steroid therapy immediately and order a temporal artery biopsy.
authors.affiliation: Department of Ophthalmology, Eberhard-Karls University Tuebingen, Schleichstr. 12, 72076 Tuebingen, Germany. efdal.Yoeruek@med.uni-tuebingen.de
authors.forename: Efdal
authors.initials: E
authors.lastname: Yoeruek
authors.forename: Peter
authors.initials: P
authors.lastname: Szurman
authors.forename: Olcay
authors.initials: O
authors.lastname: Tatar
authors.forename: Petra
authors.initials: P
authors.lastname: Weckerle
authors.forename: Helmut
authors.initials: H
authors.lastname: Wilhelm
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001706:Biopsy; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D013699:Temporal Arteries / Q000473:pathology; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D015415:Biomarkers; D005938:Glucocorticoids; D002097:C-Reactive Protein; D008775:Methylprednisolone