[New tools for the study of occupational allergies related to animals].
Animal laboratory workers are exposed at the Laboratory Animal Allergy (LAA). About 10% of them develop asthma. Currently, by the use of innovative methodologies, numerous allergens from the laboratory animals have been sequenced and analyzed. Between them, the allergens by rats and mouse, the experimental models more utilized. Proteomic approach or protein microarray permit the study of several allergens, belonging to the proteins known as lipocalins, and of immunological response in susceptible individuals. Moreover, availability of on-line data banks permit a knowledge more and more detailed and up-to-date regarding the allergens of the interest. Between the advantage of the proteomic there is the use of small amount of biological fluids, as the serum, in association with the possibility to studied a great number of allergens on a single support. The study of LAA by the use of proteomic will permit to identify the animal allergens more accurately, providing also a valid tool at the methodologies traditionally used, and for the planning of the preventive and protective measures.
D'Ovidio
M C
MC
ISPESL, Dipartimento di Medicina del Lavoro, Monte Porzio Catone, Roma. mariaconcetta.dovidio@ispesl.it
Martini
A
A
Signorini
S
S
D000485:Allergens / Q000032:analysis*; D000818:Animals; D000830:Animals, Laboratory; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology*
D000485:Allergens