title: Cytotoxicity, histopathological, microbiological and clinical aspects of an endodontic iodoform-based paste used in pediatric dentistry: a review.
abstract: This review aims at describing and comparing materials commonly used in root canal therapy, the cytotoxicity, histopathological, microbiological and clinical aspects ofa iodoform-based paste (Guedes-Pinto Paste-GPP) used in endodontic treatment of primary teeth. GPP has shown excellent biocompatibility to pulp fibroblasts and mild inflammatory reactions, having been well-tolerated by the periapical and connective tissues. Moreover, GPP bactericidal and bacteriostatic effects against many oral microorganisms were also demonstrated. Regarding clinical trials, the GPP technique has achieved success rates when considering clinical and radiographic examinations. In the face of all the above mentioned results, this paper would like to propose the use of this endodontic material as a root canal filling for primary teeth.
authors.affiliation: Departamento de Ortodontia e Odontopediatria, Faculdade de Odontologia, Universidade de Sao Paulo, Brazil. daniellafc@terra.com.br
authors.forename: Daniella Ferraz
authors.initials: DF
authors.lastname: Cerqueira
authors.forename: Anna Carolina Volpi
authors.initials: AC
authors.lastname: Mello-Moura
authors.forename: Elaine Marcílio
authors.initials: EM
authors.lastname: Santos
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Guedes-Pinto
mesh_terms: D002164:Camphor / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002733:Chlorophenols / Q000627:therapeutic use; D019140:Dental Care for Children / Q000379:methods*; D003731:Dental Caries / Q000628:therapy*; D003786:Dental Pulp Cavity / Q000187:drug effects; D003793:Dental Restoration, Permanent / Q000379:methods*; D004338:Drug Combinations; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000009:adverse effects / Q000627:therapeutic use; D010377:Pediatric Dentistry / Q000379:methods; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012294:Rifamycins / Q000009:adverse effects / Q000627:therapeutic use; D012387:Root Canal Filling Materials / Q000009:adverse effects / Q000627:therapeutic use*; D014094:Tooth, Deciduous / Q000187:drug effects*
chemical_list: D002733:Chlorophenols; D004338:Drug Combinations; D006847:Hydrocarbons, Iodinated; D012294:Rifamycins; D012387:Root Canal Filling Materials; D011092:Polyethylene Glycols; D002164:Camphor; C029804:camphorated parachlorophenol; D011239:Prednisolone; C010473:iodoform