Molecular basis of Laron dwarfism.
An autosomal recessive disorder, Laron-type dwarfism, results from peripheral unresponsiveness to growth hormone. Mutations in the growth hormone receptor have recently been identified in this syndrome. Analysis of patients with Laron-type dwarfism should provide insight into the mechanisms of hormone receptor binding and signal transduction pathways of this receptor, which belongs to a new class of transmembrane receptors.
Amselem
S
S
Department of Biochemistry and INSERM U.91, Henri Mondor Central University Hospital, F-94010 Céteil, France.
Duquesnoy
P
P
Goossens
M
M