title: Subinhibitory concentrations of antibiotics induce phenazine production in a marine Streptomyces sp.
abstract: Subinhibitory concentrations of antibiotics were found to enhance and modulate the production of new phenazines, streptophenazines A-H, in a marine Streptomyces isolate. The streptophenazines differ in length and substitution of an alkyl chain. The pattern of metabolites formed depends on the antibiotic used. In the presence of tetracycline, streptophenazines F and G were induced and the production of streptophenazines A-D was increased. When using bacitracin, mainly streptophenazine H was produced. Streptophenazines C and H showed moderate activity against Bacillus subtilis, while streptophenazine C was also active against Staphylococcus lentus.
authors.affiliation: Kieler Wirkstoff-Zentrum KiWiZ am Leibniz-Institut für Meereswissenschaften (IFM-GEOMAR), Kiel, Germany. mitova_maya@yahoo.it
authors.forename: Maya I
authors.initials: MI
authors.lastname: Mitova
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: Jutta
authors.initials: J
authors.lastname: Wiese
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010619:Phenazines