Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin.
The role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved by increasing the dose in the clinical setting.
Sarker
Shafiqul A
SA
ICDDR,B, GPO Box 128, Dhaka 1000, Bangladesh. sasarker@icddrb.org
Pant
Neha
N
Juneja
Lekh R
LR
Hammarström
Lennart
L
D000818:Animals; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000276:immunology; D003967:Diarrhea / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D004195:Disease Models, Animal; D004530:Egg Yolk / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control* / Q000821:virology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007136:Immunoglobulins