Crosstalk of signalling processes of innate immunity with Yersinia Yop effector functions.
The interaction of microbial pathogens with host cells critically determines the genesis of infectious diseases. Gram-negative, pathogenic bacteria from the genus Yersinia deliver a set of virulence proteins, the so-called Yersinia outer proteins (Yops), inside the eukaryotic cell where the Yops perturb key cellular functions of innate immunity. In our past work, we used Yersinia enterocolitica as a tool to explore the crosstalk between the bacterial pathogen and its host cell. Yersiniae counteract phagocytosis, suppress proinflammatory signalling and trigger apoptosis in macrophages. Macrophage cell death results from the deregulation of Toll-like receptors-dependent conserved signalling pathways by Yersinia infection. We summarize our current understanding about the signals and reactions elicited on both the bacterial and host cell sides that determine the fate of the infected cell along with the innate immune response.
Ruckdeschel
Klaus
K
Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. k.ruckdeschel@uke.uni-hamburg.de
Deuretzbacher
Anne
A
Haase
Rudolf
R
D000818:Animals; D017209:Apoptosis; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D015007:Yersinia / Q000378:metabolism / Q000502:physiology*; D015009:Yersinia Infections / Q000382:microbiology*; D015008:Yersinia enterocolitica / Q000378:metabolism*
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D051193:Toll-Like Receptors; D025801:Ubiquitin; C109227:YopP protein, Yersinia; D046988:Proteasome Endopeptidase Complex