title: Successful rescue of an apocrine gland carcinoma metastatic to the cervical lymph nodes by mitoxantrone coupled with trains of permeabilizing electrical pulses (electrochemotherapy).
abstract: Canine apocrine gland carcinoma is a locally aggressive neoplasm that can occasionally lead to metastatic spread, thus mimicking the behavior of their human counterpart. In this paper we describe the successful treatment of a cervical metastatic spread of this neoplasia by using mitoxantrone selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduction from the first cycle of electrochemotherapy (ECT) and complete remission by the time of its fourth session. Neither systemic or local toxicities were detected during the whole course of therapy. The dog is in complete remission after six months from his last treatment. Electrochemotherapy is a safe and efficacious therapy for metastatic carcinoma and warrants further investigation.
authors.affiliation: S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy. info@enricospugnini.net
authors.forename: Enrico P
authors.initials: EP
authors.lastname: Spugnini
authors.forename: Ivan
authors.initials: I
authors.lastname: Dotsinsky
authors.forename: Nikolay
authors.initials: N
authors.lastname: Mudrov
authors.forename: Angelo
authors.initials: A
authors.lastname: De Luca
authors.forename: Carlo
authors.initials: C
authors.lastname: Codini
authors.forename: Gennaro
authors.initials: G
authors.lastname: Citro
authors.forename: Alfredo
authors.initials: A
authors.lastname: D'Avino
authors.forename: Alfonso
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001050:Apocrine Glands / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000556:secondary / Q000628:therapy / Q000662:veterinary*; D018572:Disease-Free Survival; D004285:Dogs; D053672:Electrochemotherapy / Q000662:veterinary*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008942:Mitoxantrone / Q000627:therapeutic use*; D012074:Remission Induction; D016879:Salvage Therapy; D013544:Sweat Gland Neoplasms / Q000473:pathology / Q000628:therapy / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D008942:Mitoxantrone