Fabrication, modification, and application of poly(methyl methacrylate) microfluidic chips.
Poly(methyl methacrylate) (PMMA) is particularly useful for microfluidic chips with the features of low price, excellent optic transparency, attractive mechanical and chemical properties, ease of fabrication and modification, biocompatibility, etc. During the past decade, significant progress in the PMMA microfluidic chips has occurred. This review, which contains 120 references, summarizes the recent advances and the key strategies in the fabrication, modification, and application of PMMA microfluidic chips. It is expected that PMMA microchips should find a wide range of applications and will lead to the creation of truly disposable microfluidic devices.
Chen
Yun
Y
Department of Analytical Chemistry, School of Pharmacy, Fudan University, Shanghai, P. R. China.
Zhang
Luyan
L
Chen
Gang
G
D000596:Amino Acids / Q000032:analysis; D002264:Carboxylic Acids / Q000032:analysis; D002619:Chemical Warfare Agents / Q000032:analysis; D004247:DNA / Q000032:analysis; D046209:Electrophoresis, Microchip / Q000295:instrumentation; D004785:Environmental Pollutants / Q000032:analysis; D053834:Explosive Agents / Q000032:analysis; D007477:Ions / Q000032:analysis; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D009844:Oligosaccharides / Q000032:analysis; D063065:Organophosphonates / Q000032:analysis; D010455:Peptides / Q000032:analysis; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000032:analysis
D000596:Amino Acids; D002264:Carboxylic Acids; D002619:Chemical Warfare Agents; D004785:Environmental Pollutants; D053834:Explosive Agents; D007477:Ions; D009844:Oligosaccharides; D063065:Organophosphonates; D010455:Peptides; D011506:Proteins; D004247:DNA; D019904:Polymethyl Methacrylate