title: RNA editing, DNA recoding and the evolution of human cognition.
abstract: RNA editing appears to be the major mechanism by which environmental signals overwrite encoded genetic information to modify gene function and regulation, particularly in the brain. We suggest that the predominance of Alu elements in the human genome is the result of their evolutionary co-adaptation as a modular substrate for RNA editing, driven by selection for higher-order cognitive function. We show that RNA editing alters transcripts from loci encoding proteins involved in neural cell identity, maturation and function, as well as in DNA repair, implying a role for RNA editing not only in neural transmission and network plasticity but also in brain development, and suggesting that communication of productive changes back to the genome might constitute the molecular basis of long-term memory and higher-order cognition.
authors.affiliation: ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia.
authors.forename: John S
authors.initials: JS
authors.lastname: Mattick
authors.forename: Mark F
authors.initials: MF
authors.lastname: Mehler
mesh_terms: D000243:Adenosine Deaminase / Q000235:genetics / Q000378:metabolism; D020087:Alu Elements; D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D015894:Genome, Human; D006801:Humans; D017393:RNA Editing; D016601:RNA-Binding Proteins
chemical_list: D016601:RNA-Binding Proteins; D004247:DNA; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase