title: The factorial structure of the Chronic Liver Disease Questionnaire (CLDQ).
abstract: OBJECTIVE
  The Chronic Liver Disease Questionnaire (CLDQ) is a disease-specific instrument designed to assess health-related quality of life in patients with chronic liver disease. The aim of this paper is to present the psychometric properties of a German version of this questionnaire. A special focus is placed on the analysis of the CLDQ's factorial structure.
  
  
  METHODS
  Five hundred and twenty-four patients completed the CLDQ from May 1999 to October 2006. The results were subject to item analysis, reliability and validity assessments, and confirmatory and exploratory factor analysis.
  
  
  RESULTS
  The distribution characteristics on the item and scale level were satisfactory. Internal consistency was good to excellent; retest reliability acceptable. Validity could be confirmed by characteristic subscale correlations with other quality-of-life scales. Confirmatory factor analysis could not sufficiently reproduce the original factor structure. Exploratory factor analysis suggested five out of six subscales of the original version and yielded a new subscale: leep."
  
  
  CONCLUSIONS
  CLDQ's reliability and validity have been confirmed. In addition, the demonstrated practical administration of the questionnaire suggests that it should serve as a routine quality of life assessment of patients with chronic liver disease.
authors.affiliation: Department of Hepatobiliary and Transplant Surgery, Center for Transplantation Medicine, University Medical Center Eppendorf, Hamburg, Germany. khschulz@uke.uni-hamburg.de
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Schulz
authors.forename: Sylvia
authors.initials: S
authors.lastname: Kroencke
authors.forename: Heike
authors.initials: H
authors.lastname: Ewers
authors.forename: Holger
authors.initials: H
authors.lastname: Schulz
authors.forename: Zobair M
authors.initials: ZM
authors.lastname: Younossi
mesh_terms: D003627:Data Interpretation, Statistical; D005260:Female; D005858:Germany; D006801:Humans; D008107:Liver Diseases / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires