Brønsted-acid-catalyzed activation of nitroalkanes: a direct enantioselective aza-Henry reaction.
A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifunctional Brønsted-acid-catalyzed activation of nitroalkanes provides an efficient access to alpha,beta-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.
Rueping
Magnus
M
Institute of Organic Chemistry and Chemical Biology, University Frankfurt, Frankfurt am Main, Germany. M.rueping@chemie.unifrankfurt.de
Antonchick
Andrey P
AP