title: Influence of sleep disturbance on quality of life of patients with epilepsy.
abstract: The frequency of sleep disturbances in patients with epilepsy and their impact on quality of life (QoL) have been documented in a few reports, and the results are conflicting. We identified 124 consecutive epilepsy out-patients who visited the epilepsy out-patient clinics at the University Hospital of Alexandroupolis, the AHEPA Hospital in Thessaloniki and the Aeginitio Hospital in Athens. We measured excessive daytime sleepiness (EDS) with the Epworth Sleepiness Scale (ESS), obstructive sleep apnea (OSA) with the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ), and insomnia with the Athens Insomnia Scale (AIS). We evaluated quality of life by the Quality of Life in Epilepsy Inventory (QOLIE-31). EDS was found in 16.9% (21/124) of epileptic patients, OSA in 28.2% (35/124), and insomnia in 24.6% (30/122). In multivariate analysis, we found that insomnia was an independent negative factor for Total score (p<0.001), Overall QoL (p=0.002), Emotional well-being (p<0.001), Energy/fatigue (p<0.001), Cognitive functioning (p=0.04) and Social functioning (p=0.03), and OSA only for Cognitive functioning (p=0.01). According to our findings, EDS, OSA, and insomnia are frequent in epileptic patients. Epileptic patients with sleep disturbance, mainly insomnia, have significant QoL impairment.
authors.affiliation: Department of Neurology, Democritus University of Thrace, University - General Hospital, Alexandroupolis, Greece.
authors.forename: Charitomeni
authors.initials: C
authors.lastname: Piperidou
authors.forename: Anna
authors.initials: A
authors.lastname: Karlovasitou
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Triantafyllou
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Terzoudi
authors.forename: Theodoros
authors.initials: T
authors.lastname: Constantinidis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vadikolias
authors.forename: Ioannis
authors.initials: I
authors.lastname: Heliopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vassilopoulos
authors.forename: Stavros
authors.initials: S
authors.lastname: Balogiannis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004827:Epilepsy / Q000150:complications* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012044:Regression Analysis; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology*; D011795:Surveys and Questionnaires