Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues.
Högenauer
Klemens
K
Novartis Institutes for Biomedical Research, Brunner Strasse 59, 1235 Wien, Austria. klemens.hoegenauer@novartis.com
Billich
Andreas
A
Pally
Charles
C
Streiff
Markus
M
Wagner
Trixie
T
Welzenbach
Karl
K
Nussbaumer
Peter
P
D002384:Catalysis; D000068876:Fingolimod Hydrochloride; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D008956:Models, Chemical; D010766:Phosphorylation; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000378:metabolism*; D011409:Propylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000099157:Sphingosine Kinase
D000068876:Fingolimod Hydrochloride; D007166:Immunosuppressive Agents; D017853:Phosphotransferases (Alcohol Group Acceptor); D011409:Propylene Glycols; D013110:Sphingosine; D000099157:Sphingosine Kinase