title: Case-control comparison of at-home and hospital care for allogeneic hematopoietic stem-cell transplantation: the role of oral nutrition.
abstract: BACKGROUND
  Acute graft-versus-host disease (GVHD) was reduced using home care compared with hospital care after allogeneic hematopoietic stem-cell transplantation (ASCT).
  
  
  METHODS
  Between March 1998 and December 2006, 601 patients underwent ASCT at our unit. Requirements for at-home ASCT were fulfilled by 76 patients. A control group of 76 patients treated in the hospital were matched for age, sex, diagnosis, stage of disease, conditioning, stem-cell source, type of donor, and immunosuppression. Oral nutrition was determined as median kcal/kg/day for the first 21 days after ASCT.
  
  
  RESULTS
  The home-care patients received more oral nutrition per day than hospital controls (P<0.05). Number of days at home correlated with oral nutrition (P=0.004). In multivariate analysis, acute GVHD of grades II to IV was associated with poor oral nutrition (P=0.003) and hospital care (P=0.06). Transplant-related mortality was associated with acute GVHD grades II to IV (P<0.0001) and bacteremia (P=0.004). In addition to acute GVHD and bacteremia, death was associated with absence of chronic GVHD (P=0.012). Five-year survival was 65% in patients treated at home, when compared with 47% in the controls (P=0.04).
  
  
  CONCLUSIONS
  Better oral nutrition may be one reason for the reduced probability of acute GVHD and better survival with at-home care than with hospital care.
authors.affiliation: Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. britt-marie.svahn@karolinska.se
authors.forename: Britt-Marie
authors.initials: BM
authors.lastname: Svahn
authors.forename: Mats
authors.initials: M
authors.lastname: Remberger
authors.forename: Mona
authors.initials: M
authors.lastname: Heijbel
authors.forename: Eva
authors.initials: E
authors.lastname: Martell
authors.forename: Marie
authors.initials: M
authors.lastname: Wikström
authors.forename: Britta
authors.initials: B
authors.lastname: Eriksson
authors.forename: Ruza
authors.initials: R
authors.lastname: Milovsavljevic
authors.forename: Jonas
authors.initials: J
authors.lastname: Mattsson
authors.forename: Olle
authors.initials: O
authors.lastname: Ringdén
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D003152:Community Health Nursing; D002149:Energy Intake; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006699:Home Care Services; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000601:surgery; D015596:Nutrition Assessment; D010289:Parenteral Nutrition, Total / Q000401:mortality; D014184:Transplantation, Homologous / Q000502:physiology*