Growth hormone-releasing peptide and its analogues Novel stimuli to growth hormone release.
GHRPs are oligopeptides with GH-releasing effects in humans when given by either parenteral or oral routes; in addition, nonpeptide pharmacologic analogues have recently been synthesized. Although the exact mechanism of action of these agents has not been fully established, there is probably a dual site of action on both the pituitary and the hypothalamus, possibly involving regulatory factors in addition to GHRH and somatostatin. GHRPs and their analogues may have a potential role in the treatment of short stature in children or in other situations of GH deficiency, such as adult GH deficiency, obesity, catabolic states, and even normal old age.
Korbonits
M
M
Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE, England.
Grossman
A B
AB