Prolactin variants.
Prolactin (PRL) is one of the most versatile hormones of the pituitary in terms of biologic actions, but how a single molecule is able to evoke so many different responses in the organism is not known. Research in recent years has uncovered a surprising degree of structural polymorphism for PRL, the different forms having variable biopotencies. Such findings lend credence to the hypothesis that the molecular heterogeneity of PRL is one of the mechanisms for creating diversity in the biologic actions of this hormone.
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Yagya N. Sinha is at the Whittier Institute for Diabetes and Endrocrinology at Scripps Memorial Hospital, La Jolla, CA 92037, USA.