mRNA export: RNP remodeling by DEAD-box proteins.
The DEAD-box protein Dbp5 was thought to remodel ribonucleoproteins and displace proteins from these complexes in an ATP-dependent fashion to allow for mRNA export from the nucleus. A recent study on Dbp5 shows, however, that its ADP-bound form may also perform an important function in displacing export factors from mRNA.
Linder
Patrick
P
Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, CH-1211, Genève 4, Switzerland. Patrick.linder@medecine.unige.ch
D000244:Adenosine Diphosphate / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism*
D012333:RNA, Messenger; D012261:Ribonucleoproteins; D000244:Adenosine Diphosphate; D053487:DEAD-box RNA Helicases