Therapeutic approaches for control of transcription factors in allergic disease.
The inflammatory response observed in allergic disease involves multiple cell types but is orchestrated in part by the T(H)2 cytokines IL-4, IL-5, and IL-13. In recent years, the transcription factors that control the expression and function of these cytokines have been elucidated, including signal transducer and activator of transcription 6, GATA3, nuclear factor of activated T cells, and nuclear factor kappaB. These molecules are attractive targets for therapeutic intervention because they regulate the expression of numerous effector molecules and functions simultaneously. For instance, the immunosuppressive agents glucocorticoids and cyclosporin A both function by repressing the activity of transcription factors through a variety of mechanisms. In this review we examine the role of each transcription factor in allergic disease and discuss approaches that have been taken to therapeutically interfere with transcription factor function in allergic disease.
Cousins
David J
DJ
MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom. david.cousins@kcl.ac.uk
McDonald
Joanne
J
Lee
Tak H
TH
D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000502:physiology*
D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D014157:Transcription Factors