title: No pathogenic rearrangement within the DISC 1 gene in psychosis.
abstract: A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR-based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement.
authors.affiliation: INSERM U, IFRMP, Rouen, France.
authors.forename: Solenn
authors.initials: S
authors.lastname: Legallic
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Bou
authors.forename: Sadeq
authors.initials: S
authors.lastname: Haouzir
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Allio
authors.forename: Caroline
authors.initials: C
authors.lastname: Demily
authors.forename: Michel
authors.initials: M
authors.lastname: Petit
authors.forename: Thierry
authors.initials: T
authors.lastname: Frebourg
authors.forename: Florence
authors.initials: F
authors.lastname: Thibaut
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
mesh_terms: D001483:Base Sequence; D017931:DNA Primers; D015321:Gene Rearrangement; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C412476:DISC1 protein, human; D017931:DNA Primers; D009419:Nerve Tissue Proteins