title: Effects of honey as a scolicidal agent on the hepatobiliary system.
abstract: OBJECTIVE
  To examine the effects of 10% diluted honey, which has been shown to be scolicidal, on the liver and biliary system and determine whether it could be used as a scolicidal agent in the presence of biliary-cystic communication.
  
  
  METHODS
  Thirty Wistar-Albino rats were divided into two groups. Honey with 10% dilution in the study group and 0.9% saline (NaCl) in the control group were injected into the common bile ducts of rats through a 3-mm duodenotomy. The animals were sacrificed 6 mo after the procedure. Histopathological, biochemical, and radiological examinations were performed for evaluation of side effects.
  
  
  RESULTS
  At the end of the sixth month, liver function tests were found to be normal in both groups. The tissue samples of liver and ductus choledochus of the honey group showed no histomorphologic difference from the control group. No stricture on the biliary tree was detected on the retrograde cholangiograms.
  
  
  CONCLUSIONS
  According to these results, we concluded that 10% diluted honey could be used as scolicidal agent safely in the presence of biliary-cystic communication.
authors.affiliation: Department of General Surgery, Ankara Training and Research Hospital, Ankara 06340, Turkey. kilicoglubulent@yahoo.com
authors.forename: Bulent
authors.initials: B
authors.lastname: Kilicoglu
authors.forename: Kemal
authors.initials: K
authors.lastname: Kismet
authors.forename: Sibel-Serin
authors.initials: SS
authors.lastname: Kilicoglu
authors.forename: Serap
authors.initials: S
authors.lastname: Erel
authors.forename: Omur
authors.initials: O
authors.lastname: Gencay
authors.forename: Kadriye
authors.initials: K
authors.lastname: Sorkun
authors.forename: Esra
authors.initials: E
authors.lastname: Erdemli
authors.forename: Okan
authors.initials: O
authors.lastname: Akhan
authors.forename: Mehmet-Ali
authors.initials: MA
authors.lastname: Akkus
authors.forename: Iskender
authors.initials: I
authors.lastname: Sayek
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000187:drug effects*; D003135:Common Bile Duct / Q000187:drug effects / Q000473:pathology; D005260:Female; D006722:Honey; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D012492:Salts / Q000494:pharmacology
chemical_list: D012492:Salts