A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection.
BACKGROUND
Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain.


OBJECTIVE
To compare the incidence and intensity of injection pain with 1% Propofol-LCT with 1% Propofol-LCT/MCT in female populations for minor surgery under total intravenous anesthesia (TIVA).


METHODS
One hundred and ten female patients were double-blind randomized into two groups. Group long-chain triglycerdes (L) received 1% propofol-LCT while group long-chain triglycerides/medium-chain triglycerides (L/M) received 1% propofol-LCT/MCT. All patients received no benzodiazepine premedication and fentanyl 1 microg/kg was given 3 minutes before propofol injection. The propofol 1 mg/kg was manually injected at 0.5 mL/sec. The verbal rating score (VRS 0-10) was recorded on pain of injection. VRS > 4 indicates a significant response to pain.


RESULTS
There was a significantly greater incidence and intensity of injection pain in group L compared with group L/M (p < 0.001 and p = 0.013 respectively).


CONCLUSIONS
Propofol-LCT/MCT is superior to propofol-LCT on reducing pain of injection.
Sundarathiti
Petchara
P
Department of Anesthesiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400, Thailand.
Boonthom
Nuanjai
N
Chalacheewa
Theerawat
T
Jommaroeng
Porpimon
P
Rungsithiwan
Wanadee
W
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D015994:Incidence; D010146:Pain / Q000209:etiology* / Q000517:prevention & control; D010147:Pain Measurement; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D012307:Risk Factors; D014280:Triglycerides / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology
D018686:Anesthetics, Intravenous; D014280:Triglycerides; D015742:Propofol