title: New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.
abstract: A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.
authors.affiliation: Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, MN, USA.
authors.forename: Frank Joy
authors.initials: FJ
authors.lastname: Ankudey
authors.forename: Paul
authors.initials: P
authors.lastname: Kiprof
authors.forename: Emily R
authors.initials: ER
authors.lastname: Stromquist
authors.forename: Leng Chee
authors.initials: LC
authors.lastname: Chang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D013302:Streptomyces / Q000187:drug effects*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; C475724:bromotyrosine; D014443:Tyrosine