Matrix metalloproteinases and their tissue inhibitors in endocrinology.
Matrix metalloproteinases (MMPs) and their natural inhibitors (TIMPs) have been widely implicated in tissue resorption, degradation, and fibrosis in a range of normal and abnormal processes, but recently defined additional actions suggest much broader and independent roles for different members of these gene families. This review examines the involvement of hormones in regulation of MMPs and TIMPs and focuses on known and potential roles of particular interest to endocrinologists.
Salamonsen
L A
LA
The Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia.