Is IGF-1 involved in the regulatory modifications of cholesterolemia following the administration of embryonary peptides?
Significant modifications of IGF-1 and cholesterol (total and LDL) were observed following the administration of an extract of embryonary peptides (EP) to old subjects for 60 days. For most of the subjects, due to the aging process, the initial values of the biochemical parameters were shifted towards pathological range. Following the administration of EP, the serum levels of IGF-1 and cholesterol (total and LDL) were shifted towards the physiological limits for their age. The most significant modifications towards physiological range were observed for subjects with high, initial levels of IGF-1, when the decrease was striking (1-2 orders of magnitude). For these subjects, significant modifications were observed simultaneously for cholesterol. The modifications induced following the administration of EP exhibit a regulatory feature, as they are dependent on the initial levels of these parameters. The action of EP on the levels of IGF-1 and cholesterol was significantly equal for both sexes, but the influence of EP was more clear-cut in men. In conclusion, our results support an implication of IGF-1 in the regulatory mechanisms of cholesterolemia in old subjects following the long-term administration of EP.
Mihăescu
G F
GF
Hipocrate 2002-Serv. Trade Company, Bucharest, Romania. hip2002@zappmobile.ro
Olinescu
R M
RM
Grigorescu
Alexandra
A
D000367:Age Factors; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D019587:Dietary Supplements; D015387:Egg Proteins, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006304:Health Status; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology; D012737:Sex Factors
D015387:Egg Proteins, Dietary; D010455:Peptides; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol