title: Elevated osteopontin levels in patients with peripheral arterial disease.
abstract: This study was carried out to compare concentrations of osteopontin (OPN) and osteoprotegerin (OPG) in peripheral arterial disease (PAD). The study population consisted of 200 consecutive subjects in whom both OPN/OPG and ankle-brachial index were measured. It was found that OPN levels, but not OPG levels, were significantly more increased in patients with PAD than those without PAD. Serum OPN levels were significantly lower in subjects with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers than those without these agents. In this study, it has been demonstrated for the first time that serum OPN levels are related to PAD. Inhibition of renin- angiotensin system could decrease OPN levels and prevent the progression of PAD.
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Nagano, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Koshikawa
authors.forename: Kazunori
authors.initials: K
authors.lastname: Aizawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kasai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Izawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomita
authors.forename: Setsuo
authors.initials: S
authors.lastname: Kumazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsutsui
authors.forename: Jun
authors.initials: J
authors.lastname: Koyama
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Shimodaira
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Uichi
authors.initials: U
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000842:Ankle / Q000098:blood supply; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001916:Brachial Artery / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D053244:Osteoprotegerin / Q000097:blood; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D053244:Osteoprotegerin; C506895:SPP1 protein, human; C506030:TNFRSF11B protein, human; D053495:Osteopontin