title: Morphological analysis of the interstitial ultrasonic ablation in porcine liver in vivo.
abstract: BACKGROUND
  The shape of the induced thermal ablation area is as important as its dimension. The aim of this study was to analyze the size reproducibility and the aspect of the interstitial ultrasonic ablation obtained by a planar transducer in porcine liver in vivo.
  
  
  METHODS
  Five pigs were used. Two complete ultrasonic lesions were made in each animal under pedicle clamping. All the lesions underwent MR examination on day 7 and then a histological analysis.
  
  
  RESULTS
  The tested probe has the advantage of providing a step-by-step and highly directional treatment in the target zone. The ultrasonic lesions presented as well-defined and homogenous areas of tissue coagulation. The lesion volumes ranged from 8.1 to 92.3 cm3 with an averaged lesion length of 56 mm at gross examination. Three-dimensional reconstruction of the lesions from the MR images showed cylindrical and conical shapes. Large intrahepatic vessels distorted the lesion shape, and the vicinity of the application to the liver surface increased significantly the volume of the ultrasonic necrosis. Histological examination showed complete necrosis in the area of damage.
  
  
  CONCLUSIONS
  The ultrasonic ablation has a regular shape, always with sharply defined borders. However, it showed some variability in the size of the induced lesions.
authors.affiliation: Inserm U556, Université de Lyon, Lyon, France. belhassen.seket@chu-lyon.fr
authors.forename: B
authors.initials: B
authors.lastname: Seket
authors.forename: C
authors.initials: C
authors.lastname: Lafon
authors.forename: R
authors.initials: R
authors.lastname: Salomir
authors.forename: J Y
authors.initials: JY
authors.lastname: Chapelon
authors.forename: C
authors.initials: C
authors.lastname: Paquet
authors.forename: J Y
authors.initials: JY
authors.lastname: Scoazec
authors.forename: D
authors.initials: D
authors.lastname: Cathignol
mesh_terms: D000818:Animals; D021621:Imaging, Three-Dimensional; D008113:Liver Neoplasms / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D013552:Swine; D014159:Transducers; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000592:standards*