title: [Study on genetic polymorphisms of P-selectins in Chinese Han of Chengdu and Thai populations].
abstract: OBJECTIVE
  To study the gene polymorphisms of position --2123 C/G,--1969 G/A,--1817 T/C in promoter region and of Thr715Pro in exon thirteenth of P-selectin in the Chinese Han of Chengdu and Thai populations, and simultaneously to compare distributions of genotype and allelic frequencies of P-selectins among different races. Methods The genotypes and allele frequencies of the P-selectin base --2123 C/G,--1969 G/A,-1817 T/C and amino acid Thr715Pro were detected by polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) to 120 healthy Chinese Han of Chengdu and 110 Thai population.
  
  
  RESULTS
  There were no significant differences in the genotype and allele distribution of--2123 C/G,--1969 G/A,--1817 T/C polymorphisms for the P-selectin gene between Chinese Han of Chengdu and Thai populations (P > 0.05), in which compared with England and American, the distribution of P-selectin genotype and allele had significantly differences among ethnics (P < 0.001). No polymorphism of Thr715Pro was found in this study. Conclusion In Chinese Han of Chengdu and Thai populations the polymorphisms exist at base position--2123 C/G,--1969 G/A and --1817 T/C in promoter region of P-selectin. There are no significant differences in the genotype and allele distribution of the P-selectin gene polymorphisms between Chinese Han of Chengdu and Thai populations, but significantly different distribution of P-selectin gene polymorphisms occur among ethnics.
authors.affiliation: Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Ye-sheng
authors.initials: YS
authors.lastname: Wei
authors.forename: Lin-bo
authors.initials: LB
authors.lastname: Gao
authors.forename: Yin-hua
authors.initials: YH
authors.lastname: Zhu
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Tai
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Yang
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Liang
authors.forename: Mei-li
authors.initials: ML
authors.lastname: Lu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D019007:P-Selectin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013785:Thailand / Q000208:ethnology
chemical_list: D019007:P-Selectin