Elevated osteopontin levels in patients with peripheral arterial disease.
This study was carried out to compare concentrations of osteopontin (OPN) and osteoprotegerin (OPG) in peripheral arterial disease (PAD). The study population consisted of 200 consecutive subjects in whom both OPN/OPG and ankle-brachial index were measured. It was found that OPN levels, but not OPG levels, were significantly more increased in patients with PAD than those without PAD. Serum OPN levels were significantly lower in subjects with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers than those without these agents. In this study, it has been demonstrated for the first time that serum OPN levels are related to PAD. Inhibition of renin- angiotensin system could decrease OPN levels and prevent the progression of PAD.
Koshikawa
Megumi
M
Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Nagano, Japan.
Aizawa
Kazunori
K
Kasai
Hiroki
H
Izawa
Atsushi
A
Tomita
Takeshi
T
Kumazaki
Setsuo
S
Tsutsui
Hiroshi
H
Koyama
Jun
J
Shimodaira
Shigetaka
S
Takahashi
Masafumi
M
Ikeda
Uichi
U
D000368:Aged; D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000842:Ankle / Q000098:blood supply; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001916:Brachial Artery / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D053244:Osteoprotegerin / Q000097:blood; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome; D015854:Up-Regulation
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D053244:Osteoprotegerin; C506895:SPP1 protein, human; C506030:TNFRSF11B protein, human; D053495:Osteopontin