Effects of alpha1-acid glycoprotein on hemostasis in experimental septic peritonitis.
Pathogenesis of hemostasis disorders in septic peritonitis and the possibility of their correction with acute phase protein (alpha1-acid glycoprotein; two doses of 150 mg/kg) were experimentally studied on outbred albino rats. Platelets count in the peripheral blood and their adhesion to endothelium did not change during peritonitis, while aggregation activity increased due to increased rate and shorter time of aggregation, which was associated with the development of hypercoagulation involving the intrinsic and common coagulation pathways and reduction of antithrombin activity. alpha1-Acid glycoprotein increased platelet count above the normal level, normalized aggregation rate, some blood clotting parameters, and antithrombin activity. Hence, alpha1-acid glycoprotein is a polyfunctional protein modulating all pathogenetic components in the development of blood clotting disorders during septic peritonitis.
Osikov
M V
MV
Department of Pathophysiology, Chelyabinsk State Medical Academy. mvo2003@list.ru
Makarov
E V
EV
Krivokhizhina
L V
LV
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D008297:Male; D009961:Orosomucoid / Q000494:pharmacology*; D010538:Peritonitis / Q000188:drug therapy* / Q000503:physiopathology; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D018805:Sepsis / Q000188:drug therapy* / Q000503:physiopathology
D009961:Orosomucoid