[Immunoregulation of IL-18 in mice with radiated damage].
OBJECTIVE
To explore the immunoregulation of IL-18 in the mice radiated by 60Co.


METHODS
32 C57 mice were radiated by 60Co and then treated by IL-18.2 weeks later, the transformation of lymphocytes, the ability of NK cells to kill tumor cells, the subtype of T cells and the content of IgG in serum were tested.


RESULTS
IL-18 increased the function of lymphocyte transformation in 60Co radiated mice, enhanced the cytotoxic activity of NK cells against tumor cells of A375, U973 and KG1, and up-regulated the amount of CD4+T cells. However, the level of IgG in the serum of the radiated mice was not regulated by IL-18.


CONCLUSIONS
IL-18 can enhance the immune function of the mice radiated by 60Co.
Ben
Song-bin
SB
College of Life Sciences, Liaoning University, Shenyang 110036, China. bensongbin@hotmail.com
Zhao
Hong-li
HL
Ge
Quan-zhi
QZ
Dong
Yu
Y
D000818:Animals; D045744:Cell Line, Tumor; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects* / Q000528:radiation effects*; D007074:Immunoglobulin G / Q000097:blood; D020382:Interleukin-18 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011897:Random Allocation
D003037:Cobalt Radioisotopes; D007074:Immunoglobulin G; D020382:Interleukin-18