COUP-TF an orphan member of the steroid/thyroid hormone receptor superfamily.
COUP-TFs are orphan members of the steroid/thyroid hormone receptor superfamily. They are transcription factors that are highly conserved across species and have a wide spectrum of binding specificity. In tissue cultures, COUP-TFs repress the transactivation function of several other members of the steroid/thyroid hormone receptor superfamily, and they also negatively regulate the transcription from promoters of many other genes. The expression profile of COUP-TFs in several species suggests that they play an important role in development and differentiation.
Qiu
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The Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Tsai
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Tsai
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