A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats.
Dopamine has a critical role in drug reinforcement and the reinstatement of drug seeking due to priming or exposure to drug-associated cues. In contrast, the role of dopamine in stress-induced reinstatement is not clear. We have previously demonstrated that acute food deprivation, a clinically relevant stressor, reinstates heroin seeking in rats via a leptin-dependent mechanism. Recent reports have suggested a modulating role for leptin on dopamine transmission and drug-related behaviours. Thus, here we investigated the role of dopamine in acute food deprivation-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin (0.05 mg/kg per infusion) for 10 d. Following training, heroin seeking was extinguished and rats were tested for 48-h food deprivation-induced reinstatement while pretreated with the dopamine D1-, D2-, or D3-like receptor antagonists: SCH 23390 (0.0, 5.0 or 10.0 microg/kg), raclopride (0.0, 50.0 or 100.0 microg/kg) or NGB 2904 (0.0, 0.1 or 5.0 mg/kg), respectively. The dopamine D1-like receptor antagonist, SCH 23390, but neither of the other antagonists, showed a dose-dependent attenuation of food deprivation-induced reinstatement. Our results suggest that acute food deprivation-induced reinstatement may be mediated, at least in part, by activation of the dopamine D1-like receptor.
Tobin
Stephanie
S
Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
Newman
Amy H
AH
Quinn
Tammie
T
Shalev
Uri
U
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D003463:Cues; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005108:Extinction, Psychological / Q000187:drug effects; D005449:Fluorenes / Q000494:pharmacology; D005508:Food Deprivation / Q000502:physiology*; D003932:Heroin / Q000008:administration & dosage*; D008297:Male; D009294:Narcotics / Q000008:administration & dosage*; D010879:Piperazines / Q000494:pharmacology; D020891:Raclopride / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D012054:Reinforcement, Psychology; D012646:Self Administration; D013997:Time Factors
D001552:Benzazepines; D018492:Dopamine Antagonists; D005449:Fluorenes; C116818:NGB 2904; D009294:Narcotics; D010879:Piperazines; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D020891:Raclopride; D003932:Heroin