Strain distribution pattern of immune nephritis--a follow-up study.
Previous studies have indicated that the NZW, DBA/1, 129/sv and BUB strains are particularly sensitive to experimental anti-glomerular basement membrane (GBM)-induced immune nephritis. The present study extends previous observations by examining eight additional inbred mouse strains for their susceptibility to immune nephritis. Unlike the ALR/Lt, CAST/Ei, DDY/JclSidSeyFrk, FVB/NJ, PERA/Ei, SB/Le and BALB/c strains, the C58 mouse strain was observed to be particularly susceptible to experimental immune nephritis, with CBA mice being a close second. In contrast to the other strains, C58 mice uniformly developed heavy proteinuria, azotemia and severe glomerulonephritis with prominent crescent formation and tubulointerstitial nephritis following challenge with anti-GBM sera. These differences were associated with increased murine Ig deposition, leukocyte infiltration and IFN-gamma production within the kidneys of C58 mice. Studies aimed at elucidating the genetic factors and molecular pathways responsible for the enhanced renal disease in C58 mice are warranted.
Xie
Chun
C
Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Rahman
Ziaur S M
ZS
Xie
Shangkui
S
Zhu
Jiankun
J
Du
Yong
Y
Qin
Xiangmei
X
Zhou
Hui
H
Zhou
Xin J
XJ
Mohan
Chandra
C
D000818:Animals; D017849:Animals, Inbred Strains / Q000235:genetics*; D019867:Anti-Glomerular Basement Membrane Disease / Q000235:genetics* / Q000276:immunology; D000910:Antibodies, Heterophile / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D007116:Immunization, Passive; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D051379:Mice; D011507:Proteinuria / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D013045:Species Specificity
D000910:Antibodies, Heterophile; D001323:Autoantibodies; D007371:Interferon-gamma