title: Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.
abstract: OBJECTIVE
  The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.
  
  
  METHODS
  We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.
  
  
  RESULTS
  Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5+/-5.2 ng/mL vs. 20.0+/-7.3 ng/mL, P<0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (P<0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (rho=0.458, P<0.05) and HOMA-R (rho=0.444, P<0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (F=5.294, P<0.05) in female patients with diabetes.
  
  
  CONCLUSIONS
  These findings suggest that BDNF may contribute to glucose metabolism.
authors.affiliation: Department of Medical Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyama-kita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Fujinami
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Ohta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Obayashi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Fukui
authors.forename: Goji
authors.initials: G
authors.lastname: Hasegawa
authors.forename: Naoto
authors.initials: N
authors.lastname: Nakamura
authors.forename: Hana
authors.initials: H
authors.lastname: Kozai
authors.forename: Saeko
authors.initials: S
authors.lastname: Imai
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ohta
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D000419:Albuminuria; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012016:Reference Values
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D007328:Insulin; D020738:Leptin; D003404:Creatinine