title: Treatment of congenital pseudarthrosis of the tibia with native bovine BMP: a case report.
abstract: Bone morphogenetic proteins (BMP) have been shown to induce bone formation and union in long bone defects and nonunions. We report a case of congenital pseudarthrosis of the tibia treated with a composite implant consisting of a biocoral frame, collagen carrier, and native bovine BMP extract. A six-year-old boy had persisting congenital proximal tibial pseudarthrosis despite six prior operations. At surgery, the sclerotic surfaces of both fragments were excised, fixation was performed using Ilizarov's device, and the composite implant and an autograft were applied to the nonunion site. Three months after the operation, radiographs showed union, and at four months, the Ilizarov device was removed. Two years later, the proximal pseudarthrosis remained clinically and radiologically united. It is concluded that BMP may contribute to the healing of congenital tibial pseudarthrosis of the tibia.
authors.affiliation: Department of Surgery, Oulu University Hospital, P.O. Box 21, FIN-90029 OYS, Finland. sauli.kujala@fimnet.fi
authors.forename: Sauli
authors.initials: S
authors.lastname: Kujala
authors.forename: Vesa
authors.initials: V
authors.lastname: Vähäsarja
authors.forename: Willy
authors.initials: W
authors.lastname: Serlo
authors.forename: Pekka
authors.initials: P
authors.lastname: Jalovaara
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D002417:Cattle; D002648:Child; D006801:Humans; D008297:Male; D011542:Pseudarthrosis / Q000151:congenital* / Q000188:drug therapy*; D013977:Tibia
chemical_list: D019485:Bone Morphogenetic Proteins