Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis.
This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >or=0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.
Kanunfre
Kelly Aparecida
KA
Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de São Paulo, University of São Paulo, São Paulo, Brazil.
Leite
Olavo Henrique Munhoz
OH
Lopes
Max Igor
MI
Litvoc
Marcelo
M
Ferreira
Antonio Walter
AW
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D001938:Brazil; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C117940:CFP-10 protein, Mycobacterium tuberculosis; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D007371:Interferon-gamma