Potential anthelmintic: D-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditis elegans.
No anthelmintic sugars have yet been identified. Eight ketohexose stereoisomers (D- and L-forms of psicose, fructose, tagatose and sorbose), along with D-galactose and D-glucose, were examined for potency against L1 stage Caenorhabditis elegans fed Escherichia coli. Of the sugars, D-psicose specifically inhibited the motility, growth and reproductive maturity of the L1 stage. D-Psicose probably interferes with the nematode nutrition. The present results suggest that D-psicose, one of the rare sugars, is a potential anthelmintic.
Sato
Masashi
M
Department of Applied Biological Science, Kagawa University, 2393 Miki-Ikenobe, Kagawa, 761-0795, Japan.
Kurose
Hiroyuki
H
Yamasaki
Toru
T
Izumori
Ken
K
D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects*; D005632:Fructose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005690:Galactose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006601:Hexoses / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D021261:Parasitic Sensitivity Tests; D013013:Sorbose / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000969:Antinematodal Agents; D006601:Hexoses; C003243:psicose; D005632:Fructose; D005947:Glucose; D013013:Sorbose; C030192:tagatose; D005690:Galactose