[Antiblastic drug exposure: statistical analysis of the data coming from environmental monitoring of a site devoted to drug production].
An environmental monitoring strategy was carried out for the determination of surface concentrations of cyclophosphamide (CP), ifosfamide (IF) and 5-fluorouracil (5-FU) in a drug preparation room of an oncology ward. Analytes were determined by wipe tests, liquid-liquid extraction with diatomaceous earths and GC/MSMS or HPLC/UV analysis. The analysed 249 samples showed concentrations of CP, IF and 5-FU varying in the ranges 0.020-18.83, 0.100-26.96, 0.740-208.9 microg/dm2, respectively. It is noteworthy that the 9.3% (CP), 18.6% (IF) and 76.3% (5-FU) of the investigated surfaces showed high contamination levels, with analytes amount higher than 0.5 microg/dm2 and a progressive contamination decrement going from workbenches, floor, hood planes and other examined surfaces (interphone, telephone etc.). A significant correlation (rhos = 0.303, p = 0.001) between the measured analyte concentration and the analyte handled amount was found only in the case of IF, and a diffuse contamination (traces of all the three analytes) was found on all investigated surfaces, even when analytes were not been used during the sampling days.
Miraglia
N
N
Dipartimento di Medicina Sperimentale, Sezione di Medicina del Lavoro, Igiene e Tossicologia Industriale, Seconda Università degli Studi di Napoli, Via L. De Crecchio, 80138 Napoli. nadia.miraglia@unina2.it
Castiglia
L
L
Muselli
A
A
Astarita
S
S
Acampora
A
A
Sannolo
N
N
D000970:Antineoplastic Agents / Q000032:analysis*; D002617:Chemical Industry; D003520:Cyclophosphamide / Q000032:analysis*; D004784:Environmental Monitoring; D005472:Fluorouracil / Q000032:analysis*; D007069:Ifosfamide / Q000032:analysis*; D016273:Occupational Exposure / Q000032:analysis*
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D005472:Fluorouracil; D007069:Ifosfamide