title: [Multiple hepatic metastases and ovarian metastases of colon cancer responding to combined therapy with S-1 and CPT-11--a case report].
abstract: We report a patient with multiple hepatic metastases and ovarian metastases of transverse colon cancer treated by combination of S-1 and CPT-11. The patient was a 51-year-old woman with cancer of the transverse colon and multiple hepatic metastases. She had undergone surgery. Resection of the transverse colon and left ovary was performed because left ovarian metastases were found during the operation. After the operation, the patient was given chemotherapy with S-1 (120 mg/body on days 1-14) and CPT-11 (150 mg/body on day 1). After completion of 11 courses of chemotherapy, abdominal CT scans revealed that the LDAs of the liver had disappeared, so the patient was judged to have achieved CR. No adverse event was observed. This case suggests that the combination of S-1 and CPT-11 may be an effective regimen for advanced colon cancer with multiple hepatic metastases.
authors.affiliation: Department of Surgery, Hiratsuka Kyosai Hospital.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Inagaki
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Katayama
authors.forename: Ryuji
authors.initials: R
authors.lastname: Shiraishi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Tanabe
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oosawa
authors.forename: Hiroo
authors.initials: H
authors.lastname: Wada
authors.forename: Shota
authors.initials: S
authors.lastname: Yasuda
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D004338:Drug Combinations; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002166:Camptothecin