title: CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients.
abstract: BACKGROUND
  CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk. More specifically, CYP1A1 *2B and *4 polymorphisms have been associated with high susceptibility to lung cancer among cigarette smokers.
  
  
  METHODS
  DNA was obtained from blood samples and we studied by PCR-RFLP the distribution of CYP1A1 *2B (n=248) and *4 (n=222) polymorphisms in healthy controls and 222 lung cancer patients from a Mexican population.
  
  
  RESULTS
  Comparisons between groups showed an increased risk for lung cancer patients of *2B/*2B (18%; OR 7.6; 95% CI 3.0-19.2) and *4/ *4 genotypes (15%; OR 11.45; 95% CI 2.19-59.85) compared to the control group (1% for *2B/ *2B and 4.4% for *4/ *4). A significant association between lung cancer and homozygous *2B/ *2B passive smokers and *4/*4 ever (cigarettes) and passive smokers was also observed (p<0.05). Multivariate analysis revealed an increased risk for the *2B/*2B genotype (OR 6.83), as well as for *4/*4 (OR 28.8).
  
  
  CONCLUSIONS
  The results of the study indicate a significant association between *2B/*2B and *4/*4 genotypes and the risk of developing lung cancer among Mexicans.
authors.affiliation: Molecular Genetics Laboratory, Division of Molecular Medicine, Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco - Mexico. marthaga@foreigner.class.udg.mx
authors.forename: M P
authors.initials: MP
authors.lastname: Gallegos-Arreola
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera-Villanueva
authors.forename: R
authors.initials: R
authors.lastname: Troyo-Sanroman
authors.forename: G
authors.initials: G
authors.lastname: Morgán-Villela
authors.forename: A M
authors.initials: AM
authors.lastname: Puebla-Pérez
authors.forename: M R
authors.initials: MR
authors.lastname: Flores-Marquez
authors.forename: G M
authors.initials: GM
authors.lastname: Zúniga-González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D001483:Base Sequence; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000209:etiology / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D017931:DNA Primers; D004273:DNA, Neoplasm; D014028:Tobacco Smoke Pollution; D019363:Cytochrome P-450 CYP1A1