title: [Clinical evaluation of supplemental administration of flavoxate hydrochloride in benign prostatic hyperplasia patients with nocturia resistant to an alpha1-adrenoceptor blocker].
abstract: We examined the effectiveness of supplemental administration of flavoxate hydrochloride in patients with benign prostatic hyperplasia (BPH) whose nocturia was not adequately relieved by an alpha1-adrenoceptor blocker. Fifty-two patients who had two or more nocturnal micturition after administration of tamsulosin hydrochloride or naftopidil for 4 weeks or more received 400-600 mg of flavoxate hydrochloride in addition to an alpha1-adrenoceptor blocker for another 8-12 weeks. With supplemental administration of flavoxate hydrochloride, significant improvement was observed in the number of nocturnal micturition, total International Prostate Sympton Score, quality of life score and BPH impact index. No significant change was observed in the voided volume, Qmax, voiding time and residual urine volume. Supplemental administration of flavoxate hydrochloride is therefore effective for the improvement of nocturia and QOL in BPH patients resistant to an alpha1-adrenoceptor blocker.
authors.affiliation: Department of Urology, Hiratsuka City Hospital.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kato
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kusaka
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Shiroki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Izumitani
authors.forename: Haruyoshi
authors.initials: H
authors.lastname: Asano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ooki
authors.forename: Masanori
authors.initials: M
authors.lastname: Yanaoka
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hoshinaga
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005422:Flavoxate / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000188:drug therapy*; D010276:Parasympatholytics / Q000008:administration & dosage*; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011788:Quality of Life; D018340:Receptors, Adrenergic, alpha-1 / Q000008:administration & dosage*
chemical_list: D010276:Parasympatholytics; D018340:Receptors, Adrenergic, alpha-1; D005422:Flavoxate