title: The effect of trimebutine on the psychosocial adjustment to illness in the irritable bowel syndrome.
abstract: OBJECTIVE
  Irritable bowel syndrome (IBS) is a harassing condition leading to the impairment of the quality of life. Adjustment to illness is an important personality factor able to influence the outcome. We looked for the psychological adjustment to illness in IBS. We also investigated the effect of trimebutine, a drug frequently used in IBS, on symptoms and psychosocial adjustment to illness in IBS.
  
  
  METHODS
  A prospective randomized controlled trial including 50 consecutive patients with irritable bowel syndrome. They received either trimebutine 100 mg t.i.d (n=25, 11M/14F, aged 44+/-12 years) or placebo t.i.d. (n=25, 12M/13F, 48+/-10 years) for 2 weeks. Seven digestive symptoms were evaluated on a 0-16 scale, as well as the patient's satisfaction (scale 1-10) and the physician's satisfaction (scale 0-4) with the therapy. The psychosocial adjustment to illness was assessed by the PAIS-SR scale (self-report).
  
  
  RESULTS
  Trimebutine increased significantly the following items of the PAIS-SR questionnaire: vocational environment, domestic environment, sexual relationships, extended family relationships, social environment but not health care orientation and psychological distress. Symptom score (mean+/-SD) for pain was reduced from 13.1+/-4.0 to 2.7+/-1.1, p<0.0001 by trimebutine and from 12.5+/-3.6 to 7.7+/-2.5, p<0.05 by placebo. Bloating score was decreased by trimebutine from 10.3+/-3.6 to 2.6+/-1.2 (p<0.0001) and not by placebo (from 10.5+/-4.5 to 8.8+/-3.6 N.S.). Nausea, emesis, anorexia, diarrhea and constipation were also improved by trimebutine. Placebo improved anorexia and tended to improve nausea. Patient' s satisfaction score was 8.1+/-1.1 with trimebutine and 5.2+/-3.5 with placebo (p<0.01). Physician's satisfaction score was 3.0+/-0.7 with trimebutine and 2.2+/-1.1 with placebo (p<0.02).
  
  
  CONCLUSIONS
  Trimebutine improved symptoms and psychological adjustment to illness in irritable bowel syndrome in comparison with placebo.
authors.affiliation: Third Medical Department, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. ddumitrascu@cluj.astral.ro
authors.forename: D L
authors.initials: DL
authors.lastname: Dumitraşcu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Stănculete
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012917:Social Adjustment; D016896:Treatment Outcome; D014287:Trimebutine / Q000627:therapeutic use*
chemical_list: D005765:Gastrointestinal Agents; D014287:Trimebutine