Pharmacokinetics of dihydroartemisinin in a murine malaria model.
Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models.
Batty
Kevin T
KT
School of Pharmacy, Curtin University of Technology, Bentley, Western Australia. kevin.batty@curtin.edu.au
Gibbons
Peter L
PL
Davis
Timothy M E
TM
Ilett
Kenneth F
KF
D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics*; D037621:Artemisinins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy; D008657:Metabolic Clearance Rate; D051379:Mice; D051381:Rats; D013045:Species Specificity
D000962:Antimalarials; D037621:Artemisinins; C039060:artenimol