The aromatic hydrocarbon receptor, dioxin action, and endocrine homeostasis.
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin acts through the aromatic hydrocarbon (AH) receptor to enhance CYP1A1 gene transcription. There are notable mechanistic analogies between dioxin action and lipophilic hormone action. In addition, some of dioxin's adverse effects are associated with disruptions in endocrine homeostasis. Thus, dioxin biology intersects several disciplines, including toxicology, endocrinology, molecular biology, and public health.
Whitlock
J P
JP
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305-5332, USA.