title: Interleukin 18 receptor 1 gene polymorphisms are associated with asthma.
abstract: The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for asthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131 < or = P < or = 0.01377), five with atopic asthma (0.00066 < or = P < or = 0.00405) and two with BHR (0.01450 < or = P < or = 0.03203) in the Danish population; two SNPs were associated with atopic asthma (0.00397 < or = P < or = 0.01481) and four with BHR (0.00435 < or = P < or = 0.03544) in the UK population; four SNPs showed associations with asthma (0.00015 < or = P < or = 0.03062), two with atopic asthma (0.01269 < or = P < or = 0.04042) and three with BHR (0.00259 < or = P < or = 0.01401) in the Norwegian population; five SNPs showed associations with asthma (0.00005 < or = P < or = 0.03744), five with atopic asthma (0.00001 < or = P < or = 0.04491) and three with BHR (0.03568 < or = P < or = 0.04778) in the combined population. Three intronic SNPs (rs1420099, rs1362348 and rs1974675) showed replicated association for at least one asthma-related phenotype. These results demonstrate significant association between polymorphisms in IL18R1 and asthma.
authors.affiliation: Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhu
authors.forename: Moira K B
authors.initials: MK
authors.lastname: Whyte
authors.forename: Jorgen
authors.initials: J
authors.lastname: Vestbo
authors.forename: Karin
authors.initials: K
authors.lastname: Carlsen
authors.forename: Kai-Håkon
authors.initials: KH
authors.lastname: Carlsen
authors.forename: Warren
authors.initials: W
authors.lastname: Lenney
authors.forename: Michael
authors.initials: M
authors.lastname: Silverman
authors.forename: Peter
authors.initials: P
authors.lastname: Helms
authors.forename: Sreekumar G
authors.initials: SG
authors.lastname: Pillai
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000235:genetics*; D003718:Denmark; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D053727:Interleukin-18 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009664:Norway; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D006113:United Kingdom
chemical_list: D005819:Genetic Markers; C508572:IL18R1 protein, human; D053727:Interleukin-18 Receptor alpha Subunit