Anti-hyperglycemic activity of kiwifruit leaf (Actinidia deliciosa) in mice.
The methanol extract of kiwifruit leaf suppressed the postprandial blood glucose level after an oral administration of soluble starch or sucrose in mice. The mechanism of action is proposed to be due to the alpha-amylase-inhibiting activity in the 90% aqueous methanol fraction and alpha-glucosidase-inhibiting activity in the n-buthanol fraction, based on the results of in vitro experiments.
Shirosaki
Miyuki
M
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan, Minato-ku, Tokyo 108-8477, Japan.
Koyama
Tomoyuki
T
Yazawa
Kazunaga
K
D029042:Actinidia / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D013213:Starch / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D013395:Sucrose; D013213:Starch; D000516:alpha-Amylases; D000520:alpha-Glucosidases