In vitro activity of anidulafungin against Candida albicans biofilms.
We tested the activity of anidulafungin against 30 Candida albicans isolates. The planktonic MICs for 50 and 90% of the isolates tested (MIC(50) and MIC(90)) were < or =0.03 and 0.125 microg/ml, respectively (MIC range, < or =0.03 to 2 microg/ml). The sessile MIC(50) and MIC(90) were < or =0.03 and < or =0.03 microg/ml, respectively (MIC range, < or =0.03 to >16 microg/ml).
Jacobson
Melissa J
MJ
Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Piper
Kerryl E
KE
Nguyen
Gary
G
Steckelberg
James M
JM
Patel
Robin
R
D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000382:microbiology; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards
D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin