title: siRNAs targeting mouse myostatin.
abstract: Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively. The obtained siRNAs can be used for study of biological effects of myostatin, both in vitro and in vivo.
authors.affiliation: Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 33, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Furalyov
authors.forename: I V
authors.initials: IV
authors.lastname: Kravchenko
authors.forename: V P
authors.initials: VP
authors.lastname: Khotchenkov
authors.forename: V O
authors.initials: VO
authors.lastname: Popov
mesh_terms: D000818:Animals; D002460:Cell Line; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000378:metabolism; D055435:Myostatin; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000737:chemistry; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: C525912:Mstn protein, mouse; D055435:Myostatin; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D016212:Transforming Growth Factor beta