Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.
Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9microM while azumamide A (1) showed only weak inhibition at 19microM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.
Nakao
Yoichi
Y
Department of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. ayocha@waseda.jp
Narazaki
Genta
G
Hoshino
Takuhiro
T
Maeda
Satoko
S
Yoshida
Minoru
M
Maejima
Hiroshi
H
Yamashita
Jun K
JK
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D051379:Mice; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D010456:Peptides, Cyclic / Q000494:pharmacology*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology; D011161:Porifera / Q000737:chemistry*
D020533:Angiogenesis Inhibitors; D010456:Peptides, Cyclic; C516229:azumanide E