title: [Thyroid disease in the pregnancy and hypotrophy of newborns].
abstract: OBJECTIVE
  The aim of this study was to compare thyroidal status of mothers who delivered newborns with hypotrophy and mothers with healthy newborns.
  
  
  METHODS
  One-time cross-sectional study.
  
  
  METHODS
  3rd internal clinic FN LP, Kosice.
  
  
  METHODS
  We examined 56 mothers with hypotrophic newborns and 76 mothers with healthy newborns. The protocol included anamnesis, basic physical examination, ultrasonography of the thyroid, assessment of the mother's plasma fT4, TSH and anti-TPO levels, and comparison of the birth weight and birth length of the newborns. The results were statistically processed by PC programs StatsDirect 2.6.2 and MS Excel 2000.
  
  
  RESULTS
  The thyroid volume was significantly greater in mothers with hypotrophic newborns as in the control group (p<0.001). The birth weight and birth length was significantly lower in hypotrophic newborns (p<0.0001 resp. p<0.0001). Mothers with hypotrophic newborns had significantly higher TSH levels (p<0.0001) and higher anti-TPO levels (p<0.0001) as mothers in the control group. We found no differences in the fT4 levels in these groups.
  
  
  CONCLUSIONS
  Thyroid disease of the mother can contribute to the hypotrophy of the newborns.
authors.affiliation: III interná klinika FN LP a UP JS, Kosice, Slovenská republika.
authors.forename: V
authors.initials: V
authors.lastname: Vargová
authors.forename: V
authors.initials: V
authors.lastname: Mechírová
authors.forename: M
authors.initials: M
authors.lastname: Pytliak
authors.forename: M
authors.initials: M
authors.lastname: Tajtáková
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011247:Pregnancy; D011248:Pregnancy Complications; D013959:Thyroid Diseases / Q000150:complications*