title: [Endosaccular embolization of an intrasellar aneurysm with hypopituitarism: case report].
abstract: An 81-year-old male presented with weight loss and hyponatremia. A baseline endocrinological examination revealed anterior pituitary dysfunction. A computed tomography and MRI revealed a large, unruptured intrasellar aneurysm protruding from the right internal carotid artery and pushing the pituitary stalk leftward. The patient developed polyuria and polydipsia from 10 days after commencing corticosteroid supplementation and was diagnosed with partial central diabetes insipidus (DI). Balloon assisted endosaccular embolization was performed about one month after the posterior pituitary dysfunction was identified. The unruptured aneurysm was successfully embolized with Guglielmi detachable coils (GDCs) without narrowing of the parent vessel. DI resolved completely and the posterior pituitary dysfunction improved soon after endosaccular embolization. The remission of DI after coil embolization suggested that the DI might have been induced by the progressive mass effect of the aneurysm rather than by the steroid. An endocrinological evaluation and cerebral angiography confirmed partial recovery of anterior pituitary dysfunction and almost complete obliteration of the aneurysm, respectively at 1 year after the operation. We report a case of hypopituitarism secondary to the large intrasellar aneurysm. This aneurysm was embolized with GDCs, resulting in partial recovery of anterior pituitary dysfunction and complete recovery of posterior pituitary dysfunction.
authors.affiliation: Department of Neurosurgery, Musashino Red Cross Hospital, Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Fujii
authors.forename: Osamu
authors.initials: O
authors.lastname: Tone
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tomita
authors.forename: Masashi
authors.initials: M
authors.lastname: Tamaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Akimoto
authors.forename: Keigo
authors.initials: K
authors.lastname: Shigeta
authors.forename: Oltea
authors.initials: O
authors.lastname: Sampetrean
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kanno
authors.forename: Mika
authors.initials: M
authors.lastname: Matsushita
mesh_terms: D000369:Aged, 80 and over; D000783:Aneurysm / Q000628:therapy*; D002340:Carotid Artery Diseases / Q000628:therapy*; D002343:Carotid Artery, Internal; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology* / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome