Structural characterization and differentiation of isomeric omega-bromoalkoxy derivatives of (E)-chalcone by means of mass spectrometry.
Mass spectrometry with electron ionization and electrospray ionization have been applied to characterize and differentiate the isomeric ortho-, meta- or para-(E)-bromoalkyloxychalcones 1-15. The difference in the values of micro1-micro5 (i.e. the ratio of abundances of the selected fragment ions to those of the molecular ions) in the series of isomeric chalcones studied and the so-called "in-source" fragmentation induced by increasing cone voltage have been found to be important and reliable indicators differentiating the isomers studied.
Nowakowska
Zdzisława
Z
Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland.
D000962:Antimalarials / Q000737:chemistry; D000981:Antiprotozoal Agents / Q000737:chemistry; D001966:Bromine / Q000737:chemistry*; D002599:Chalcone / Q000737:chemistry*; D006801:Humans; D007536:Isomerism; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D000962:Antimalarials; D000981:Antiprotozoal Agents; D002599:Chalcone; D001966:Bromine