Pathogenic role of environmental toxins in immune-mediated liver diseases.
Immune-mediated liver diseases contribute significantly to morbidity and mortality due to liver failure and the need for liver transplantation. The pathogenesis of the immune-mediated chronic liver diseases, primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cirrhosis, is poorly understood. Genetic susceptibility factors may play a role, but increasing attention is being given to the association between environmental factors and these diseases. The existence of such a relationship is supported by epidemiologic surveys, animal models, and geographic clustering analyses. Unearthing the cause of this association may provide insight into the pathogenesis of immune-mediated chronic liver diseases and autoimmunity.
Stanca
Carmen M
CM
Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA.
Babar
Jawad
J
Singal
Vineet
V
Ozdenerol
Esra
E
Odin
Joseph A
JA
D000818:Animals; D016000:Cluster Analysis; D003710:Demography; D004781:Environmental Exposure / Q000009:adverse effects*; D006256:Hazardous Waste / Q000009:adverse effects; D006801:Humans; D008107:Liver Diseases / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D016031:Liver Transplantation; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D051381:Rats; D012307:Risk Factors; D014466:Ultraviolet Rays / Q000009:adverse effects; D015262:Xenobiotics / Q000633:toxicity
D006256:Hazardous Waste; D015262:Xenobiotics