Chrysogenamide A from an endophytic fungus associated with Cistanche deserticola and its neuroprotective effect on SH-SY5Y cells.
Chrysogenamide A (1), a new member of the macfortine group of alkaloids, along with four known compounds (2 approximately 5) were identified from Penicillium chrysogenum No. 005, an endophytic fungus associated with Cistanche deserticola Y. C. Ma. The new structure was elucidated on the basis of comprehensive spectral analysis. 1 exhibited a neurocyte protection effect against oxidative stress-induced cell death in SH-SY5Y cells.
Lin
Zhenjian
Z
Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Wen
Jiangni
J
Zhu
Tianjiao
T
Fang
Yuchun
Y
Gu
Qianqun
Q
Zhu
Weiming
W
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D031671:Cistanche; D005285:Fermentation; D006801:Humans; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D010408:Penicillium chrysogenum / Q000378:metabolism*; D008517:Phytotherapy; D018547:Plant Stems; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000475:Alkenes; D018696:Neuroprotective Agents; D013141:Spiro Compounds; C530001:chrysogenamide A