title: Clinical and pathological aspects of hemophilia a in Japanese Brown cattle.
abstract: A coagulopathy with subcutaneous bleeding and muscular or peritracheal/periesophageal bleeding occurred in two male Japanese Brown calves of the same dam. One of the affected calves died three days after the onset of bleeding and the other survived normally until being slaughtered despite once suffering from subcutaneous hematoma. Hemostatic tests of the latter case showed prolonged activated partial thromboplastin time (APTT), and severely reduced factor VIII activity. In addition, von Willebrand factor activity, determined by the human platelet aggregation test, was within the normal range; therefore, the calf was diagnosed with hemophilia A. These are the first bovine cases of hemophilia A definitely diagnosed clinicopathologically.
authors.affiliation: Department of Animal Science, School of Agriculture, Kyusyu Tokai University, Minamiaso-mura, Kumamoto, Japan. ymori@agri.u-tokai.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Moritomo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Shimojo
authors.forename: Keiko
authors.initials: K
authors.lastname: Miyadera
authors.forename: Maryam
authors.initials: M
authors.lastname: Khalaj
authors.forename: Yuka
authors.initials: Y
authors.lastname: Asano
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kunieda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D005169:Factor VIII / Q000378:metabolism; D017809:Fatal Outcome; D006467:Hemophilia A / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D014841:von Willebrand Factor; D005169:Factor VIII