title: Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosis.
abstract: OBJECTIVE
  The role of the hippocampus in sensory gating is unresolved as yet. The current study was conducted in order to examine the effects of hippocampal lesions on the function of auditory sensory gating.
  
  
  METHODS
  Epilepsy patients with unilateral and bilateral hippocampal sclerosis (HS) were investigated. Auditory-evoked potentials (AEPs) were recorded by multichannel scalp EEG in a double-click experiment. Gating was defined as the response decrease of the AEP components from 1st to 2nd click.
  
  
  RESULTS
  Diagnosis (left vs. right vs. bilateral HS) did not affect the amplitudes or gating of the P50, N100 or P200 components. However, diagnosis had an impact on the topography of the N100 component after its peak maximum: In right HS patients, the N100 was left-lateralized, while it was nearly symmetrically distributed in patients with left HS and right lateralized in patients with bilateral HS. Besides the N100, the topography of the P200 component was affected by diagnosis.
  
  
  CONCLUSIONS
  Findings suggest that auditory activity, as reflected in the N100 and P200 components, is modulated by the hippocampus, but not sensory gating in its classical definition.
  
  
  CONCLUSIONS
  Deficits in P50 gating in schizophrenia are unlikely to be explained by hippocampal deficits.
authors.affiliation: Department of Epileptology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. timm.rosburg@ukb.uni-bonn.de
authors.forename: Timm
authors.initials: T
authors.lastname: Rosburg
authors.forename: Peter
authors.initials: P
authors.lastname: Trautner
authors.forename: Eva
authors.initials: E
authors.lastname: Ludowig
authors.forename: Christoph
authors.initials: C
authors.lastname: Helmstaedter
authors.forename: Christian G
authors.initials: CG
authors.lastname: Bien
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
authors.forename: Nash N
authors.initials: NN
authors.lastname: Boutros
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012598:Sclerosis / Q000209:etiology* / Q000473:pathology; D013057:Spectrum Analysis