title: Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone.
abstract: OBJECTIVE
  To compare the efficacy of injectable lornoxicam with diclofenac, ketoprofen, and dipyrone for acute postoperative pain.
  
  
  METHODS
  Prospective, randomized, placebo-controlled, double-blind study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  200 ASA physical status I patients who were scheduled for elective septoplasty with general anesthesia.
  
  
  METHODS
  Patients were divided into 5 groups according to the intramuscularly administered analgesic drug: lornoxicam 8 mg (twice daily), diclofenac 75 mg (twice daily), ketoprofen 100 mg (twice daily), dipyrone 1 g (three times daily), and placebo (twice daily).
  
  
  METHODS
  Pain intensity was evaluated with a 0 to 100 mm Visual Analog Scale (VAS) at the 2nd, 4th, 6th, 8th, 12th, 16th, 20th, and 24th hour postoperatively. Intramuscular pethidine 1 mg/kg was administered to patients requiring additional analgesia, and treatment-related adverse effects were noted.
  
  
  RESULTS
  Pethidine requirement was found to be significantly higher in the placebo group (1.8 mg/kg per 24 hours; 95% confidence interval, 1.5-2.2) than in the other groups (P = 0.001). No significant difference in opioid requirement was found among the treated groups (P > 0.05). Postoperative VAS scores were significantly lower at specific hours in the treatment groups when compared with placebo group (P < 0.05). No statistically significant difference in adverse effects was found among the groups studied (P > 0.05).
  
  
  CONCLUSIONS
  Efficacy of lornoxicam in the management of acute postoperative pain was not superior to that of other nonopioid analgesics used in this study.
authors.affiliation: Department of Anesthesiology and Reanimation, Baskent University Faculty of Medicine, Ankara, Turkey. mesutsenertr@yahoo.co.uk
authors.forename: Mesut
authors.initials: M
authors.lastname: Sener
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Yilmazer
authors.forename: Ismail
authors.initials: I
authors.lastname: Yilmaz
authors.forename: Nesrin
authors.initials: N
authors.lastname: Bozdogan
authors.forename: Cem
authors.initials: C
authors.lastname: Ozer
authors.forename: Asli
authors.initials: A
authors.lastname: Donmez
authors.forename: Gulnaz
authors.initials: G
authors.lastname: Arslan
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D004177:Dipyrone / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use; D008297:Male; D008614:Meperidine / Q000627:therapeutic use; D008875:Middle Aged; D009300:Nasal Septum / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D004008:Diclofenac; D004177:Dipyrone; D007660:Ketoprofen; D008614:Meperidine; C059451:lornoxicam