Compressibility and compactibility of granules produced by wet and dry granulation.
The bulk properties, compactibility and compressibility of granules produced by wet and dry granulation were compared applying a rotary tablet press, three different morphological forms of calcium carbonate and two particle sizes of sorbitol. Granules from both granulation methods possessed acceptable flow properties; however, the ground (Mikhart) and cubic (Scoralite) calcium carbonate demonstrated better die-filling abilities in the tablet press than the scalenhedral calcium carbonate (Sturcal). The wet processed granules showed in general larger compression properties. This was explained as these granules were mechanical stronger and had a higher initial porosity. In some cases, a large particle surface area of calcium carbonate and sorbitol resulted in a small, insignificant improvement of the consolidation characteristics. A correlation between the compression and compaction characteristics was demonstrated.
Bacher
C
C
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark.
Olsen
P M
PM
Bertelsen
P
P
Sonnergaard
J M
JM
D002119:Calcium Carbonate; D004339:Drug Compounding; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D016062:Porosity; D011205:Povidone / Q000737:chemistry; D011208:Powders / Q000737:chemistry*; D011312:Pressure; D013012:Sorbitol / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D013607:Tablets
D007202:Indicators and Reagents; D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid; D013012:Sorbitol; D011205:Povidone; D002119:Calcium Carbonate