title: Pedigree analysis of factor XI deficiency in Japanese black cattle.
abstract: Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cattle with the factor XI deficiency. Results showed that the mutated allele of factor XI deficiency was retroactive in at least 6 or more generations of sires. Frequencies of the mutant gene were higher at 26.4% in total, and at 33.3% in sires. All 7 cattle with the homozygote of mutated allele were clinically normal, and showed no bleeding episodes. The mutated allele of factor XI deficiency might be widespread among Japanese black cattle.
authors.affiliation: Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ohba
authors.forename: Masaki
authors.initials: M
authors.lastname: Takasu
authors.forename: Naohito
authors.initials: N
authors.lastname: Nishii
authors.forename: Eri
authors.initials: E
authors.lastname: Takeda
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Maeda
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kunieda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005172:Factor XI / Q000235:genetics*; D005173:Factor XI Deficiency / Q000235:genetics / Q000662:veterinary*; D005787:Gene Frequency; D007564:Japan; D009154:Mutation / Q000235:genetics; D010375:Pedigree
chemical_list: D017931:DNA Primers; D005172:Factor XI