title: Fluoroquinolones: psychiatric adverse effects.
abstract: (1) In France, between 1985 and 2002, there were 590 reports of psychiatric adverse effects in patients receiving fluoroquinolones. These mainly included cases of confusion, hallucinations, agitation, delirium, insomnia and drowsiness. Elderly patients appear to be at greatest risk. (2) The reports implicated all available fluoroquinolones and, in most cases, oral intake. (3) Fluoroquinolone dose regimens should be reduced in cases of renal failure. The Cockcroft formula is used to derive creatinine clearance from plasma creatinine levels.
mesh_terms: D003221:Confusion / Q000139:chemically induced; D003693:Delirium / Q000139:chemically induced; D024841:Fluoroquinolones / Q000009:adverse effects*; D005602:France; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced*; D011595:Psychomotor Agitation; D012893:Sleep Wake Disorders / Q000139:chemically induced
chemical_list: D024841:Fluoroquinolones