title: The antihypertensive effect of peptides: a novel alternative to drugs?
abstract: Many types of bioactive peptides that inhibit angiotensin I, angiotensin I converting enzyme (ACE) and Ang II type 1 receptor (AT1) in the cardiovascular system contribute to the prevention and treatment of hypertension. These inhibitory peptides are derived from many food proteins or artificial synthetic products. Further research examining the bioavailability of ACE inhibitory peptides will lead to the development of more effective ACE inhibitory peptides and foods. Our research also demonstrates that ACE inhibitory peptide LAP may lower blood pressure with no adverse effects.
authors.affiliation: Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Hong
authors.forename: Luo
authors.initials: L
authors.lastname: Ming
authors.forename: Sheng
authors.initials: S
authors.lastname: Yi
authors.forename: Li
authors.initials: L
authors.lastname: Zhanxia
authors.forename: Wu
authors.initials: W
authors.lastname: Yongquan
authors.forename: Liu
authors.initials: L
authors.lastname: Chi
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004364:Pharmaceutical Preparations; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010446:Peptide Fragments; D004364:Pharmaceutical Preparations