[The effect of synthetic fragment 65-76 of monocyte chemiattractant protein-1 (MCP-1) on neointima growth after carotid artery balloon injury in rats].
Influence of synthetic fragment 65-76 of monocyte chemoattractant protein-1 (MCP-1) (peptide X) on development of neointima after balloon injury of carotid artery was investigated. Peptide X was introduced intramuscularly, 33 pg/kg, daily during 28 days after balloon injury. In days 4 and 7 after intervention, in animals receiving peptide X in comparison with control animals a substantial decrease of neointimal growth was observed. On 14 and 28 days there, was no significant difference in neointima development in rats with and without peptide treatment. Injections of peptide X did not after the C-reactive protein concentration, leukocyte number and lymphocyte subpopulations in peripheral blood. Peptide X treatment along with traditional therapy may be effective in preventing restenosis after angioplasty.
Kukhtina
N B
NB
Bashtrykov
P P
PP
Bespalova
Zh D
ZhD
Sidorova
M V
MV
Aref'eva
T I
TI
Sokolov
V O
VO
Krasnikova
T L
TL
D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000378:metabolism* / Q000473:pathology; D020212:Carotid Artery Injuries / Q000097:blood / Q000188:drug therapy*; D018932:Chemokine CCL2 / Q000494:pharmacology*; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D007958:Leukocyte Count; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017539:Tunica Intima / Q000378:metabolism*
C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D010455:Peptides; D002097:C-Reactive Protein