title: ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?
abstract: We present ModuleMiner, a novel algorithm for computationally detecting cis-regulatory modules (CRMs) in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data, and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly, CRM predictions for differentiated tissues exhibit strong enrichment close to the transcription start site, whereas CRM predictions for embryonic development gene sets are depleted in this region.
authors.affiliation: Department of Molecular and Developmental Genetics, VIB, Herestraat 49, B-3000 Leuven, Belgium. Peter.VanLoo@med.kuleuven.be
authors.forename: Peter
authors.initials: P
authors.lastname: Van Loo
authors.forename: Stein
authors.initials: S
authors.lastname: Aerts
authors.forename: Bernard
authors.initials: B
authors.lastname: Thienpont
authors.forename: Bart
authors.initials: B
authors.lastname: De Moor
authors.forename: Yves
authors.initials: Y
authors.lastname: Moreau
authors.forename: Peter
authors.initials: P
authors.lastname: Marynen
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D047108:Embryonic Development; D004742:Enhancer Elements, Genetic; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D050436:Regulatory Elements, Transcriptional / Q000235:genetics*