title: XtalView, protein structure solution and protein graphics, a short history.
abstract: From a user's point-of-view we are in the Golden Age of protein crystallographic software. In the past few decades, solving protein structures has gone from a task requiring man-months of effort to a process requiring minutes on an ordinary laptop with no human intervention required. The birth of XtalView coincided with the mainstream use of synchrotron radiation, seleno-Met phasing and it continues to be used in this age of robotic crystallization, Fed-Ex data collection and fully automated structure solution "pipelines". This article is a retrospective history of protein crystallographic computing and a discussion of the current state of the art.
authors.affiliation: ActiveSight, 4045 Sorrento Valley Blvd, San Diego, CA 92121, USA. dmcree@active-sight.com
authors.forename: Duncan E
authors.initials: DE
authors.lastname: McRee
authors.forename: Mark
authors.initials: M
authors.lastname: Israel
mesh_terms: D003196:Computer Graphics / Q000266:history; D003205:Computing Methodologies; D018360:Crystallography, X-Ray / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D011506:Proteins / Q000737:chemistry* / Q000266:history; D012984:Software / Q000266:history
chemical_list: D011506:Proteins