Effect of acute maximal exercise on lymphocyte subgroups in type 1 diabetes.
The essential therapy of diabetes mellitus includes medical nutrition therapy (MNT), exercise and medical therapy. Exercise, besides its metabolic effects, has positive influence on the immune system, but some forms of exercise may cause trauma for muscle and skeletal systems, they may also support negative effects on the immune system. Nineteen type 1 diabetic patients (mean age 22.1 +/- 2.8 yrs), followed by Diabetes Outpatient Clinic and twenty age matched male control subjects were included into the study, to demonstrate the effects of maximal, acute exercise on the immune system. The exercise test was performed according to Bruce protocol on treadmill. In diabetic subjects, increased CD19 and CD23 expressions were observed before exercise. In both groups (diabetic/control) CD3, CD4 expressions and CD4/CD8 ratio were decreased following the exercise, however expression of natural killer (NK) cells increased. Compared to type 1 diabetic patients healthy subjects had longer acute exercise that caused the increased level of CD8 expression, however type 1 diabetic patients did not show any difference. These results indicate that submaximal aerobic exercise might be recommended for type 1 diabetics without any complications because of its positive reflection on metabolic control and no negative effects on the immune system.
Salman
F
F
Department of Immunology, Institute for Experimental Medicine, Istanbul University, Vakif Gureba Caddesi 34280, Sehremini, Istanbul, Turkey. fsalman99@yahoo.com
Erten
G
G
Unal
M
M
Kiran
B
B
Salman
S
S
Deniz
G
G
Yilmaz
M T
MT
Kayserilioglu
A
A
Dinccag
N
N
D000293:Adolescent; D000328:Adult; D018941:Antigens, CD19 / Q000097:blood; D017252:CD3 Complex / Q000097:blood; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000097:blood; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000503:physiopathology; D015444:Exercise; D005080:Exercise Test; D005081:Exercise Therapy / Q000009:adverse effects; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D016131:Lymphocyte Subsets / Q000378:metabolism / Q000473:pathology; D008297:Male; D010807:Physical Endurance; D017455:Receptors, IgE / Q000097:blood; D012420:Running / Q000502:physiology
D018941:Antigens, CD19; D017252:CD3 Complex; D016827:CD8 Antigens; D017455:Receptors, IgE