title: Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk.
abstract: Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor alpha (ERalpha) gene polymorphisms were associated with POP risk by conducting a case-control association study in 88 women with POP and 153 women without POP. Genotypes of the ERalpha (ESR1) gene polymorphisms (rs17847075, rs2207647, rs2234693, rs3798577, and rs2228480) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the ESR1 rs2228480 genotypes evaluated. By using multivariable logistic regression, age and ESR1 rs2228480 genotype GA were significantly associated with POP risk. Although the sample size of women with POP studied is small, the present study shows that ERalpha genotype may be associated with POP risk.
authors.affiliation: Department of Obstetrics and Gynecology, China Medical University Hospital, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Huey-Yi
authors.initials: HY
authors.lastname: Chen
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Chung
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Lin
authors.forename: Wei-Chi
authors.initials: WC
authors.lastname: Chen
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
mesh_terms: D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014596:Uterine Prolapse / Q000453:epidemiology / Q000235:genetics*
chemical_list: D047628:Estrogen Receptor alpha