First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.
Mendes
Rodrigo E
RE
JMI Laboratories, North Liberty, IA 52317, USA.
Deshpande
Lalitagauri M
LM
Castanheira
Mariana
M
DiPersio
Joseph
J
Saubolle
Michael A
MA
Jones
Ronald N
RN
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D000069349:Linezolid; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D023303:Oxazolidinones / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D023303:Oxazolidinones; D008780:Methyltransferases; D000069349:Linezolid