Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphoma.
Personal use of hair dye has been inconsistently linked to risk of non-Hodgkin lymphoma (NHL), perhaps because of small samples or a lack of detailed information on personal hair-dye use in previous studies. This study included 4,461 NHL cases and 5,799 controls from the International Lymphoma Epidemiology Consortium 1988-2003. Increased risk of NHL (odds ratio (OR) = 1.3, 95% confidence interval (CI): 1.1, 1.4) associated with hair-dye use was observed among women who began using hair dye before 1980. Analyses by NHL subtype showed increased risk for follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) but not for other NHL subtypes. The increased risks of FL (OR = 1.4, 95% CI: 1.1, 1.9) and CLL/SLL (OR = 1.5, 95% CI: 1.1, 2.0) were mainly observed among women who started using hair dyes before 1980. For women who began using hair dye in 1980 or afterward, increased FL risk was limited to users of dark-colored dyes (OR = 1.5, 95% CI: 1.1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded.
Zhang
Yawei
Y
Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA. tongzhang.zheng@yale.edu
Sanjose
Silvia De
SD
Bracci
Paige M
PM
Morton
Lindsay M
LM
Wang
Rong
R
Brennan
Paul
P
Hartge
Patricia
P
Boffetta
Paolo
P
Becker
Nikolaus
N
Maynadie
Marc
M
Foretova
Lenka
L
Cocco
Pierluigi
P
Staines
Anthony
A
Holford
Theodore
T
Holly
Elizabeth A
EA
Nieters
Alexandra
A
Benavente
Yolanda
Y
Bernstein
Leslie
L
Zahm
Shelia Hoar
SH
Zheng
Tongzhang
T
D016022:Case-Control Studies; D005260:Female; D006202:Hair Dyes / Q000633:toxicity*; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000139:chemically induced / Q000453:epidemiology; D016015:Logistic Models; D008224:Lymphoma, Follicular / Q000139:chemically induced / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000453:epidemiology*; D012306:Risk; D011795:Surveys and Questionnaires
D006202:Hair Dyes