Audiometric changes in patients undergoing liver transplantation using distinct immunosuppressive protocols.
The aim of the study was to disclose a possible association of hearing defects with the use of either cyclosporin (CyA) or tacrolimus (FK-506) in patients undergoing liver transplantation (LT). Pure-tone audiometry (PTA) was performed in the same 42 patients before and after LT. Audiometric frequencies recorded ranged from 250 to 8000 Hz. Patients were divided into 2 groups according to the use of CyA (n = 18) or FK-506 (n = 24). We used Kolmogorov-Smirnov and subsequently Student t test, nonparametric Wilcoxon signed-rank test, and Mann-Whitney test for statistical analysis. Significance was achieved when P <or= 0.05. There was a statistically significant change in PTA results, occurring as decreased hearing perception, especially in high frequencies (4000, 6000, and 8000 Hz), in both ears of patients undergoing LT and receiving FK-506. Audiometric changes were not perceived pre- and posttransplantation in patients using CyA, except in the right ear, in the 3000-Hz range. In conclusion, LT patients presented worsening of hearing patterns after undergoing transplantation. The defect was significantly more accentuated in the high-frequency tones, particularly in individuals using FK-506 as the immunosuppressive regimen.
Fortes
Maria Elena
ME
Centro Universitário Metodista do Sul, Porto Alegre, RS, Brazil.
Marroni
Cláudio Augusto
CA
Coser
Pedro Luis
PL
de los Santos
Carlos Abaeté
CA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001299:Audiometry; D001379:Azathioprine / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D007839:Functional Laterality; D006309:Hearing / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016031:Liver Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D016559:Tacrolimus / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone; D016559:Tacrolimus