title: CD 271 (P75 neurotrophin receptor).
abstract: P75NTR (or CD271) is a member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins that share significant homology in their extracellular domains. Subsets of TNF receptors, including CD271, have a cytoplasmic death domain, although CD271 has unique intracellular structure and downstream signaling partners. CD271 is also differentiated from other members of the TNFR receptor family in that it binds pro and mature neurotrophins and affects the growth, differentiation and death of the nervous system. The ligands for CD271 are neurotrophins, which are Nerve Growth Factor (NGF), Brain-Derived Growth factor (BDNF), Neurotrophin 3 (NT3) and Neurotrophin 4/5 (NT4/5). Recent studies have provided evidence that CD271 also serves as a receptor for the pro-forms of these neurotrophins.
authors.affiliation: Department of Human Physiology, Centre for Neuroscience, Flinders University, South Australia. mary-louise.rogers@flinders.edu.au
authors.forename: M L
authors.initials: ML
authors.lastname: Rogers
authors.forename: A
authors.initials: A
authors.lastname: Beare
authors.forename: H
authors.initials: H
authors.lastname: Zola
authors.forename: R A
authors.initials: RA
authors.lastname: Rush
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D016923:Cell Death; D002455:Cell Division; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000502:physiology; D009420:Nervous System / Q000166:cytology / Q000254:growth & development; D020800:Receptor, Nerve Growth Factor / Q000737:chemistry / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology
chemical_list: D009414:Nerve Growth Factors; D020800:Receptor, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor