Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.
Synthetic analogues of the sponge natural product exiguamine A (3) have been prepared and evaluated for their ability to inhibit indoleamine 2,3-dioxygenase in vitro.
Carr
Gavin
G
Departments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
Chung
Marco K W
MK
Mauk
A Grant
AG
Andersen
Raymond J
RJ
D000818:Animals; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D011161:Porifera / Q000737:chemistry*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007211:Indoles; D011994:Recombinant Proteins; D013141:Spiro Compounds; C516830:exiguamine A