[Correlation between serum uric acid and insulin resistance].
OBJECTIVE
To assess the correlation between serum uric acid and insulin resistance in natural population of Beijing.


METHODS
1 056 people without-diabetes, 460 males and 596 females, aged 35-64 was selected from the natural population in Beijing using stratified-random sampling method. Serum uric acid, fasting blood glucose, insulin and other metabolic parameters were measured. The insulin activity index (IAI) was calculated to assess insulin resistance.


RESULTS
The natural logarithm of IAI was decreased with the elevation of serum uric acid level (F = 47.884, P < 0.001). The prevalence of insulin resistance increased with the elevation of uric acid level, from 13.8% in quartile 1 to 33.9% in quartile 4. Compared to the quartile 1, the odds ratio (OR) of the quartile 2 for prevalence of insulin resistance was 1.935; the OR of the quartile 3 was 1.590; the OR of the quartile 4 was 2. 088. Uric acid was independently correlated with insulin resistance after adjustment for sex, age and main components of metabolic syndrome (MS).


CONCLUSIONS
Serum uric acid is correlated with insulin resistance in Beijing natural population after adjustment of sex, age, and the main components of MS.
Wang
Miao
M
Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
Zhao
Dong
D
Li
Guang-Wei
GW
Wang
Wei
W
Liu
Jing
J
Liu
Jun
J
Liu
Sa
S
Qin
Lan-Ping
LP
Zhou
Guang-Hua
GH
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D016011:Normal Distribution; D014527:Uric Acid / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D014527:Uric Acid