Human dental pulp stem cells differentiate into neural crest-derived melanocytes and have label-retaining and sphere-forming abilities.
Adult tissues contain highly proliferative, clonogenic cells that meet criteria of multipotent stem cells and are potential sources for autologous reparative and reconstructive medicine. We demonstrated that human dental pulp contains self renewing human dental pulp stem cells (hDPSCs) capable of differentiating into mesenchymal-derived odontoblasts, osteoblasts, adipocytes, and chondrocytes and striated muscle, and interestingly, also into non-mesenchymal melanocytes. Furthermore, we showed that hDPSC cultures include cells with the label-retaining and sphere-forming abilities, traits attributed to multipotent stem cells, and provide evidence that these may be multipotent neural crest stem cells.
Stevens
Angelique
A
Faculté Dentaire, Université Lille 2, Lille, France. , Université Lille 2, Faculté de Médecine, Lille, France.
Zuliani
Thomas
T
Olejnik
Cecile
C
LeRoy
Helene
H
Obriot
Helene
H
Kerr-Conte
Julie
J
Formstecher
Pierre
P
Bailliez
Yves
Y
Polakowska
Renata R
RR
D000328:Adult; D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured; D003782:Dental Pulp / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000166:cytology* / Q000378:metabolism; D039902:Multipotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D009432:Neural Crest / Q000166:cytology* / Q000378:metabolism