title: [A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib].
abstract: A 70-year-old Japanese man was re-admitted because of relapse of adenocarcinoma of the lung. He received daily administration of gefitinib as second-line chemotherapy. He was given a diagnosis of drug-induced lung disease due to gefitinib on day 6 because of hypoxemia and ground glass opacities in the bilateral lung fields. There was no response to corticosteroid pulse therapy. Continuous administration of sivelestat was intravenously added from day 9. Although mechanical ventilation was required for 10 days, lung infiltrates and hypoxia gradually improved. Sivelestat and corcicosteroid was apparently effective in this case and may be useful treatment for drug-induced lung disease due to gefitinib.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital.
authors.forename: Masahide
authors.initials: M
authors.lastname: Mori
authors.forename: Takeo
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Yukie
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Namba
authors.forename: Manabu
authors.initials: M
authors.lastname: Niinaka
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yano
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitada
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kimura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Naka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okada
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Maekura
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yokota
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077156:Gefitinib; D005998:Glycine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D011799:Quinazolines / Q000009:adverse effects*; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; D011239:Prednisolone; C069195:sivelestat; D000077156:Gefitinib; D005998:Glycine