title: Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?
authors.affiliation: Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. gpierce@colorado.edu
authors.forename: Gary L
authors.initials: GL
authors.lastname: Pierce
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Larocca
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001708:Biopterins / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats
chemical_list: D001708:Biopterins; D009569:Nitric Oxide; C003402:sapropterin