title: Serum adiponectin, C-reactive protein and TNF-alpha levels in obese Korean children.
abstract: To determine whether there are differences of serum adiponectin, CRP and TNF-a levels between obese and non-obese children and to investigate the relationship between childhood obesity and inflammation.
  
  
  
  A total of 103 (73 obese, 30 non-obese) children were evaluated for height, weight, blood pressure and body mass index (BMI). We measured serum adiponectin, hs-CRP, and TNF-alpha levels and analyzed their correlation with BMI, serum glucose, lipid profile and insulin resistance.
  
  
  
  Serum adiponectin levels were significantly decreased in the obese children compared to non-obese children, and had a negative correlation with BMI, fasting glucose and HOMA-IR. Serum hs-CRP and TNF-alpha levels were increased in obese children compared to non-obese children, and had a positive correlation with BMI.
  
  
  
  Serum adiponectin level was decreased and serum CRP and TNF-alpha levels were increased in obese children. Our findings suggest that childhood obesity is associated with inflammatory processes.
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Jung Yeon
authors.initials: JY
authors.lastname: Shin
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Min Jee
authors.initials: MJ
authors.lastname: Jeung
authors.forename: So Hee
authors.initials: SH
authors.lastname: Eun
authors.forename: Chan Wook
authors.initials: CW
authors.lastname: Woo
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Yoon
authors.forename: Kee-Hyoung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D003920:Diabetes Mellitus / Q000209:etiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000208:ethnology / Q000209:etiology; D007723:Korea; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000208:ethnology; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D052242:Adiponectin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein