title: Synthesis of homochiral dihydroxy-4-nitroisoxazolines via one-pot asymmetric dihydroxylation-reduction.
abstract: Herein we report a one-pot procedure to prepare a family of homochiral dihydroxy-4-nitroisoxazolines 3. This new methodology affords the title compounds in good yields, excellent enantiopurity, and without the use of chromatography.
authors.affiliation: Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medical Chemistry, The Royal College of Surgeons in Ireland, Dublin, Ireland. madamo@rcsi.ie
authors.forename: Mauro F A
authors.initials: MF
authors.lastname: Adamo
authors.forename: Murali
authors.initials: M
authors.lastname: Nagabelli
mesh_terms: D006900:Hydroxylation; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007555:Isoxazoles