title: Role of Foxp3-positive regulatory T cells during infection.
abstract: Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3+ Treg, have been shown to play a central role in the establishment of these controlled immune responses. In this review, I discuss current hypotheses and points of polemic associated with the origin, mode of action and antigen specificity of Foxp3+ Treg during infection.
authors.affiliation: Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ybelkaid@niaid.nih.gov
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Belkaid
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D004195:Disease Models, Animal; D051858:Forkhead Transcription Factors / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007239:Infections / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000941:Antigens; D051858:Forkhead Transcription Factors