title: Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis.
abstract: OBJECTIVE
  The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis.
  
  
  METHODS
  The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49+/-13) and 30 active AS patients (males/females: 15/15, mean age: 36+/-12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52+/-8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41+/-7) as control groups for RA and AS, respectively.
  
  
  RESULTS
  MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p<0.001, AS vs healthy subjects p<0.001). After treatment MPV values significantly increased in AS and RA (p<0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p=0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r=-0.507; p=0.004).
  
  
  CONCLUSIONS
  Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA.
authors.affiliation: Hacettepe Medical Faculty, Rheumatology Department, Ankara, Turkey. Bunyamin_k@hotmail.com
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kisacik
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tufan
authors.forename: Umut
authors.initials: U
authors.lastname: Kalyoncu
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.forename: Ali
authors.initials: A
authors.lastname: Akdogan
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Ozturk
authors.forename: Sedat
authors.initials: S
authors.lastname: Kiraz
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ertenli
authors.forename: Meral
authors.initials: M
authors.lastname: Calguneri
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood; D015539:Platelet Activation; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000276:immunology*
chemical_list: D015415:Biomarkers