Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation.
Immune regulation is a complex process that depends on the maintenance of self tolerance while retaining robust immune responses against microbes. The emergence of Treg as a central mechanism for immune regulation has generated a new paradigm where Treg-resistant memory T cells and/or "defective" Treg lead to a breakdown in tolerance resulting in immune pathology. In this perspective, we highlight the opportunities and challenges in the field of Treg therapy.
Brusko
Todd
T
UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 941430540, USA.
Bluestone
Jeffrey
J
D000818:Animals; D002469:Cell Separation; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000601:surgery / Q000628:therapy*; D006801:Humans; D016381:Islets of Langerhans Transplantation; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*