title: Molecular basis of Laron dwarfism.
abstract: An autosomal recessive disorder, Laron-type dwarfism, results from peripheral unresponsiveness to growth hormone. Mutations in the growth hormone receptor have recently been identified in this syndrome. Analysis of patients with Laron-type dwarfism should provide insight into the mechanisms of hormone receptor binding and signal transduction pathways of this receptor, which belongs to a new class of transmembrane receptors.
authors.affiliation: Department of Biochemistry and INSERM U.91, Henri Mondor Central University Hospital, F-94010 Céteil, France.
authors.forename: S
authors.initials: S
authors.lastname: Amselem
authors.forename: P
authors.initials: P
authors.lastname: Duquesnoy
authors.forename: M
authors.initials: M
authors.lastname: Goossens