title: Copper-catalyzed coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-H activation.
abstract: We have developed a convenient and efficient method for coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-H activation. The protocol uses CuBr as the catalyst, NBS as the free radical initiator, CH(3)CN as the solvent, and the alkynylation was selectively performed on the methyl of tertiary aliphatic amines at 80 degrees C. This is an economical and practical method for the synthesis of propargylamines.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, PR China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Niu
authors.forename: Zhengming
authors.initials: Z
authors.lastname: Yin
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000588:Amines; D003300:Copper