title: Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta.
abstract: BACKGROUND
  Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta.
  
  
  METHODS
  In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction.
  
  
  RESULTS
  Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction.
  
  
  CONCLUSIONS
  These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.
authors.affiliation: Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. jecaminp@gmail.com
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Caminos
authors.forename: Susana B
authors.initials: SB
authors.lastname: Bravo
authors.forename: C Ruth
authors.initials: CR
authors.lastname: González
authors.forename: Maria F
authors.initials: MF
authors.lastname: Garcés
authors.forename: Libia A
authors.initials: LA
authors.lastname: Cepeda
authors.forename: Adriana C
authors.initials: AC
authors.lastname: González
authors.forename: Fernando
authors.initials: F
authors.lastname: Cordido
authors.forename: Miguel
authors.initials: M
authors.lastname: López
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
mesh_terms: D054369:Agouti-Related Protein / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D005865:Gestational Age; D007031:Hypothalamus / Q000378:metabolism*; D044342:Malnutrition / Q000235:genetics / Q000503:physiopathology*; D053486:Melanocortins / Q000096:biosynthesis; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009478:Neuropeptide Y / Q000096:biosynthesis / Q000235:genetics; D009479:Neuropeptides / Q000096:biosynthesis* / Q000235:genetics; D010920:Placenta / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats / Q000502:physiology*; D017207:Rats, Sprague-Dawley; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: C515197:AGRP protein, rat; D054369:Agouti-Related Protein; D053486:Melanocortins; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D009479:Neuropeptides; D012333:RNA, Messenger; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D011333:Pro-Opiomelanocortin