[A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib].
A 70-year-old Japanese man was re-admitted because of relapse of adenocarcinoma of the lung. He received daily administration of gefitinib as second-line chemotherapy. He was given a diagnosis of drug-induced lung disease due to gefitinib on day 6 because of hypoxemia and ground glass opacities in the bilateral lung fields. There was no response to corticosteroid pulse therapy. Continuous administration of sivelestat was intravenously added from day 9. Although mechanical ventilation was required for 10 days, lung infiltrates and hypoxia gradually improved. Sivelestat and corcicosteroid was apparently effective in this case and may be useful treatment for drug-induced lung disease due to gefitinib.
Mori
Masahide
M
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital.
Iwasaki
Takeo
T
Nakazawa
Yukie
Y
Namba
Yoshinobu
Y
Niinaka
Manabu
M
Yano
Yukihiro
Y
Kitada
Seigo
S
Kimura
Hiromi
H
Naka
Nobuyuki
N
Okada
Tatsuya
T
Nakagawa
Masaru
M
Maekura
Ryoji
R
Yokota
Soichiro
S
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077156:Gefitinib; D005998:Glycine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D011799:Quinazolines / Q000009:adverse effects*; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D011799:Quinazolines; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; D011239:Prednisolone; C069195:sivelestat; D000077156:Gefitinib; D005998:Glycine