title: Cystic struma ovarii (with macrocystic change).
abstract: In this article, a case of cystic struma ovarii with macrocystic change is presented. Cysts derived from struma ovarii may mimic a mucinous or serous cystadenoma. A careful examination for any thyroid microfollicles within fibrous septa or areas of solid stroma is key. In problematic cases, immunohistochemical staining with thyroglobulin and thyroid transcription factor-1 may be required to establish the diagnosis.
authors.affiliation: Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts, USA.
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Piragua
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Otis
authors.forename: Michel
authors.initials: M
authors.lastname: Prefontaine
authors.forename: Liron
authors.initials: L
authors.lastname: Pantanowitz
mesh_terms: D000368:Aged; D003560:Cysts / Q000473:pathology*; D005260:Female; D006042:Goiter / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D009687:Nuclear Proteins / Q000096:biosynthesis; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology*; D013330:Struma Ovarii / Q000150:complications / Q000473:pathology*; D000074482:Thyroid Nuclear Factor 1; D013965:Thyroidectomy; D014157:Transcription Factors / Q000096:biosynthesis
chemical_list: C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors