[Cancer chemopreventive agents: glucosinolates and their decomposition products in white cabbage (Brassica oleracea var. capitata)].
A number of recent epidemiological studies have indicated that high intake of white cabbage may be associated with a lower risk of neoplastic diseases such as cancer of the pancreas, breast, prostate, stomach, and lungs. The anticarcinogenic activity is related to the presence of biologically active components in this vegetable. The chemopreventive effects of cabbage may be connected with modulation of the activity of phase I and II detoxification enzymes and other mechanisms triggered by glucosinolates and products of their decomposition, which are formed as a result of hydrolysis catalyzed by the enzyme myrosinase. The products of glucosinolate decomposition influence a number of cellular processes through the regulation of transcription factor levels, signaling pathways, the cell cycle, and apoptosis. The beneficial activities and especially the chemopreventive effects of the compounds present in cabbage point to the necessity of formulating scientifically based dietary recommendations enabling the optimal exploitation of this vegetable in health protection.
Smiechowska
Anna
A
Katedra Chemii Analitycznej, Wydział Chemiczny, Politechnika Gdańska. anna_smiechowska@o2.pl
Bartoszek
Agnieszka
A
Namieśnik
Jacek
J
D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry; D001937:Brassica / Q000737:chemistry*; D018890:Chemoprevention / Q000379:methods*; D004790:Enzyme Induction; D005961:Glucosinolates / Q000737:chemistry* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000096:biosynthesis / Q000737:chemistry*; D006801:Humans; D008658:Inactivation, Metabolic; D009369:Neoplasms / Q000201:enzymology / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D005961:Glucosinolates; D006026:Glycoside Hydrolases