The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment results.
The Shanghai Women's Asthma and Allergy Study is the first population-based incidence study designed to assess the associations of dietary antioxidant intake and measures of oxidative stress and antioxidant enzyme activity with development of adult-onset asthma and allergic rhinitis. A total of 65,732 participants in the Shanghai Women's Health Study, an ongoing cohort study in seven districts of Shanghai, People's Republic of China, were recruited to the Shanghai Women's Asthma and Allergy Study from 2003 to 2007. Dietary intake was assessed in the parent study by using a validated and quantitative food frequency questionnaire at baseline recruitment and at the first biennial follow-up survey. Blood and urine samples were collected to measure baseline oxidative stress, antioxidant enzyme activity, and nutrient levels at the baseline survey. Incident asthma and allergic rhinitis were assessed by using a modification of the International Study of Asthma and Allergies in Childhood questionnaire during the biennial in-person survey of the Shanghai Women's Health Study. Diagnosis of asthma was confirmed by either methacholine challenge testing or test of reversibility to beta-agonists. Dietary antioxidant intake, plasma antioxidants, antioxidant enzymes, and urinary isoprostanes, a marker of oxidative stress, were measured prior to disease onset. This paper describes the study objectives, design, population demographics, and recruitment results.
Hartert
Tina V
TV
Division of Allergy, Pulmonary and Critical Care Medicine, School of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-8300, USA. tina.hartert@vanderbilt.edu
Deng
Xinqing
X
Hartman
Terryl J
TJ
Wen
Wanqing
W
Yang
Gong
G
Gao
Yu-Tang
YT
Jin
Meiling
M
Bai
Chunxue
C
Gross
Myron
M
Roberts
L Jackson
LJ
Sheller
James R
JR
Christman
John
J
Dupont
William
W
Griffin
Marie
M
Shu
Xiao Ou
XO
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D001249:Asthma / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D015994:Incidence; D007407:Interviews as Topic; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016387:Women's Health
D000975:Antioxidants; D015415:Biomarkers