title: Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors.
abstract: A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@mm.ewha.ac.kr
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Ra-Young
authors.initials: RY
authors.lastname: Lee
authors.forename: Seung-Yon
authors.initials: SY
authors.lastname: Lee
authors.forename: Hwa-Jin
authors.initials: HJ
authors.lastname: Chung
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Kwang-Hoe
authors.initials: KH
authors.lastname: Chung
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D015195:Drug Design; D006131:Growth Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008956:Models, Chemical; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D006131:Growth Inhibitors; D010982:Platelet-Derived Growth Factor; D020928:Mitogen-Activated Protein Kinases