title: Effect of cardiac resynchronization therapy in isolated ventricular noncompaction in adults: follow-up of four cases.
abstract: BACKGROUND
  An isolated ventricular noncompaction (IVNC) is an unclassified cardiomyopathy and, despite the increasing awareness of and interest in this disorder, the role of cardiac resynchronization therapy (CRT) remains obscure.
  
  
  OBJECTIVE
  The purpose of this study was to clarify the long-term effect of CRT on IVNC in adult patients.
  
  
  METHODS
  Four cases of IVNC were included in this study. Before the CRT device was implanted, all four patients (54 +/- 16-year-old, 4 males) presented with symptomatic congestive heart failure. Echocardiography revealed their systolic dysfunction and their left ventricular ejection fraction (LVEF) was 21 +/- 8%. There was also mechanical dyssynchrony observed between the LV septum and free wall area. The QRS duration was "narrow" (112 and 120 ms) in two patients. One patient had been resuscitated from ventricular fibrillation (VF) and two had nonsustained ventricular tachycardia (VT). A CRT defibrillator (CRT-D) was implanted in three patients with VT/VF and a CRT pacemaker (CRT-P) in a patient without VT/VF. The LV lead was positioned in a lateral branch of the coronary sinus where a thickened noncompacted wall existed.
  
  
  RESULTS
  During the follow-up period (28 +/- 23 months), their congestive heart failure had improved in terms of the cardiothoracic ratio on the chest X-ray, B-type natriuretic peptide level, LV systolic dimension, and LVEF. No episodes of defibrillation shocks were observed.
  
  
  CONCLUSIONS
  CRT may improve the prognosis and quality-of-life in patients with an IVNC with mechanical dyssynchrony.
authors.affiliation: Yokohama Rosai Hospital, Yokohama, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Oginosawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nogami
authors.forename: Kyoko
authors.initials: K
authors.lastname: Soejima
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Aonuma
authors.forename: Shoichi
authors.initials: S
authors.lastname: Kubota
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sato
authors.forename: Aiko
authors.initials: A
authors.lastname: Sugiyasu
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshida
authors.forename: Shinya
authors.initials: S
authors.lastname: Kowase
authors.forename: Mihoko
authors.initials: M
authors.lastname: Sakamaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Kurosaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kato
mesh_terms: D000328:Adult; D002304:Cardiac Pacing, Artificial; D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000517:prevention & control*