title: Inclusion or exclusion of intratumoral vessels in relative cerebral blood volume characterization in low-grade gliomas: does it make a difference?
abstract: We assessed the influence of inclusion (method 1) and exclusion (method 2) of intratumoral vessels when determining maximum relative cerebral blood volume (rCBVmax) in 3 types of low-grade gliomas (LGGs): astrocytomas, oligoastrocytomas, and oligodendrogliomas. Method 1 yielded significantly higher mean rCBVmax than method 2. However, only method 2 demonstrated a significant (P = .026) association between rCBVmax and membership of a differently ranked histologic category. Exclusion of intratumoral vessels appears, therefore, preferable when determining rCBVmax in LGGs.
authors.affiliation: Lysholm Department of Neuroradiology, University College London, London, United Kingdom. g.brasil@ion.ucl.ac.uk
authors.forename: G Brasil
authors.initials: GB
authors.lastname: Caseiras
authors.forename: J S
authors.initials: JS
authors.lastname: Thornton
authors.forename: T
authors.initials: T
authors.lastname: Yousry
authors.forename: C
authors.initials: C
authors.lastname: Benton
authors.forename: J
authors.initials: J
authors.lastname: Rees
authors.forename: A D
authors.initials: AD
authors.lastname: Waldman
authors.forename: H R
authors.initials: HR
authors.lastname: Jäger
mesh_terms: D001810:Blood Volume; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology*; D002560:Cerebrovascular Circulation; D005910:Glioma / Q000098:blood supply* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity