Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases.
A series of metal complexes of cobalt(II), nickel(II) and copper(II) have been synthesized with newly synthesized biologically active 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole and 8-formyl-7-hydroxy-4-methylcoumarin, which have been characterized by elemental analyses, spectroscopic measurements (IR, UV-vis, fluorescence, ESR), magnetic measurements and thermal studies. Electrochemical study of the complexes is also reported. All the complexes are soluble to limited extent in common organic solvents but soluble to larger extent in DMF and DMSO and are non-electrolytes in DMF and DMSO. All these Schiff bases and their complexes have also been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by MIC method. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.
Bagihalli
Gangadhar B
GB
P.G. Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, Karnataka, India.
Avaji
Prakash Gouda
PG
Patil
Sangamesh A
SA
Badami
Prema S
PS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D001681:Biological Assay; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D019216:Metals, Heavy / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013696:Temperature; D014230:Triazoles / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D019216:Metals, Heavy; D009942:Organometallic Compounds; D012545:Schiff Bases; D014230:Triazoles; C045575:1,2,4-triazole; D003035:Cobalt; D003300:Copper; D009532:Nickel