Cytotoxic-antineoplastic derivatives of prenyl-1,2-naphthohydroquinone.
Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of alpha-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI50 values in the microM-concentration level.
Molinari
Aurora
A
Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. amolinar@ucv.cl
Oliva
Alfonso
A
Ojeda
Claudia
C
del Corral
José M Miguel
JM
Castro
M Angeles
MA
Cuevas
Carmen
C
San Feliciano
Arturo
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D006873:Hydroquinones