title: Mifepristone for ectopic ACTH secretion in metastatic endocrine carcinomas: report of two cases.
abstract: Ectopic adrenocorticotropin secretion (EAS) remains a therapeutic challenge whenever the tumor responsible for the syndrome is not amenable to curative resection. Two cases of EAS related to metastatic foregut-derived endocrine carcinomas led us to use mifepristone, an antagonist of both progesterone and glucocorticoids. Mifepristone clearly improved skin lesions and diabetes associated with hypercorticism. The beneficial effect lasted for about 10 months. In both cases, recurrent hypertension and hypokalemia eventually required adrenalectomy.
authors.affiliation: Unité de Jour d'Oncologie Médicale Multidisciplinaire, Hôpital Edouard Herriot, Lyon, France.
authors.forename: Philippe A
authors.initials: PA
authors.lastname: Cassier
authors.forename: Sawsan
authors.initials: S
authors.lastname: Abou-Amara-Olivieri
authors.forename: Pascal
authors.initials: P
authors.lastname: Artru
authors.forename: Marie-George
authors.initials: MG
authors.lastname: Lapalus
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Riou
authors.forename: Catherine
authors.initials: C
authors.lastname: Lombard-Bohas
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000473:pathology*; D004064:Digestive System / Q000473:pathology; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D015735:Mifepristone / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D011188:Potassium / Q000097:blood
chemical_list: D006727:Hormone Antagonists; D015735:Mifepristone; D011188:Potassium; D006854:Hydrocortisone