Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines.
An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.
Xie
Hexin
H
Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.
Zu
Liansuo
L
Oueis
Hanine R
HR
Li
Hao
H
Wang
Jian
J
Wang
Wei
W
D002384:Catalysis; D004583:Electrons; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D006573:Heterocyclic Compounds, 1-Ring; D007659:Ketones; D011724:Pyridazines; D011392:Proline