The role of sulfation in thyroid hormone metabolism.
Sulfate conjugation is a significant metabolic reaction for thyroxine and especially so for triiodothyronine and lower iodothyronines in rats. Triiodothyronine sulfation has also been demonstrated in humans. Sulfation accelerates the deiodinative breakdown of iodothyronines by the type I iodothyronine deiodinase in liver and thus represents a rate-limiting step in one of the elimination pathways of thyroid hormone.
Visser
T J
TJ
Department of Internal Medicine III and Clinical Endocrinology, Erasmus University Medical School, Rotterdam, The Netherlands.
van Buuren
J C
JC
Rutgers
M
M
Eelkman Rooda
S J
SJ
de Herder
W W
WW