title: [Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I].
abstract: Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.
authors.affiliation: II. Medizinische Klinik, Klinikum Augsburg, Stenglinstrasse 2, 86156, Augsburg, Deutschland. ralf.schulze@2med.zk.augsburg-med.de
authors.forename: R
authors.initials: R
authors.lastname: Schulze
authors.forename: W
authors.initials: W
authors.lastname: Behr
authors.forename: H
authors.initials: H
authors.lastname: Wittwer
authors.forename: S
authors.initials: S
authors.lastname: Harwix
authors.forename: K
authors.initials: K
authors.lastname: Murmann
authors.forename: W
authors.initials: W
authors.lastname: V Scheidt
authors.forename: W
authors.initials: W
authors.lastname: Ehret
authors.forename: G
authors.initials: G
authors.lastname: Schlimok
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects; D003374:Coumarins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009336:Necrosis / Q000139:chemically induced / Q000188:drug therapy; D011486:Protein C / Q000008:administration & dosage*; D020151:Protein C Deficiency / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D011486:Protein C; C030123:coumarin