title: [The association between obesity indices in adolescence and carotid intima-media thickness in young adults: Kangwha Study].
abstract: OBJECTIVE
  The aim of this study is to investigate the association between obesity indices (body mass index, weight, waist-hip ratio and waist circumference) in adolescents and the carotid intima-media thickness (C-IMT) in early adulthood. We also wanted to identify the best predictor for C-IMT among these obesity indices.
  
  
  METHODS
  This study used community-based prospective cohort study, known as the Kangwha Study, and the data we used were from subjects who were 16-years old in 1996 (defined as "adolescence") and 25 years-old in 2005 (defined as "early adulthood"). The 256 subjects (113 men and 143 women) who were used for analysis participated in both follow-ups, and they underwent B-mode ultrasonography of the carotid arteries at the early adulthood follow-up. Obesity indices were defined as the body mass index, weight, waist-hip ratio and waist circumference. The C-IMT was defined as the mean of the maximal IMT of each common carotid artery. The C-IMT and obesity indices associations were evaluated via multivariable regression, logistic regression and the receiver-operator characteristic curve analyses.
  
  
  RESULTS
  In men, all the obesity indices in adolescence were showed to have statistically significant positive association with C-IMT in early adulthood. However, no such relationship was showed in women. On multiple regression and logistic regression analysis, the waist-hip ratio showed the biggest relationship with the C-IMT among the 4 obesity indices. However, there were no statistical significant differences and no best predictor was found. For the women, the obesity incidences and C-IMT showed no relationships.
  
  
  CONCLUSIONS
  This study suggested that obesity in adolescence was related to an increase C-IMT in healthy young Korean men.
authors.affiliation: Graduate School of Public Health, Yonsei University, Seoul, Korea.
authors.forename: Yoo Jung
authors.initials: YJ
authors.lastname: Lee
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Hyeon Chang
authors.initials: HC
authors.lastname: Kim
authors.forename: Nam Wook
authors.initials: NW
authors.lastname: Hur
authors.forename: Il
authors.initials: I
authors.lastname: Suh
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002339:Carotid Arteries / Q000473:pathology*; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000473:pathology* / Q000503:physiopathology; D011446:Prospective Studies; D012737:Sex Factors; D017539:Tunica Intima / Q000473:pathology*; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D008055:Lipids