title: Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.
abstract: An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi, Sakyo-ku, Kyoto, 606-8501, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yagura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Motomiya
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
authors.forename: Akira
authors.initials: A
authors.lastname: Iida
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification*; D015153:Blotting, Western; D002461:Cell Line, Transformed; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification*; D003043:Cocarcinogenesis; D005260:Female; D035264:Flowers / Q000737:chemistry; D036562:Helichrysum / Q000737:chemistry*; D051379:Mice; D018632:Mice, Inbred SENCAR; D010212:Papilloma / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D010703:Phorbol Esters; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D014610:Uzbekistan; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D016588:Anticarcinogenic Agents; D047188:Chalcones; D010703:Phorbol Esters; D010936:Plant Extracts; C027321:isosalipurposide; D015127:9,10-Dimethyl-1,2-benzanthracene; C027329:naringenin chalcone; D048051:p38 Mitogen-Activated Protein Kinases