title: Achievement of therapeutic goals and utilization of evidence-based cardiovascular therapies in coronary heart disease patients with chronic kidney disease.
abstract: To evaluate whether the presence of chronic kidney disease (CKD) influenced the rate of prescription of evidence-based cardiovascular preventive therapies and attainment of therapeutic goals in patients with stable coronary heart disease, 7,884 patients (mean age 65.4 years; 81.7% men; 22.4% with CKD) attended to in 1,799 primary-care centers and who had had a coronary event requiring hospitalization in the previous 6 months to 10 years were recruited. Glomerular filtration rate (GFR) was estimated using the MDRD Study equation. Results indicated that patients with CKD received more diuretics (47.6% vs 32.8%; p = 0.034), calcium channel blockers (29.3% vs 23.2%, p = 0.027); and blockers of the angiotensin-renin system (76.4% vs 65.3%; p <0.001). The lower prescription rate of antiaggregants, beta blockers, and statins in subjects with CKD did not reach statistical significance in multivariate analysis. A lower percentage of subjects with CKD achieved good control of blood pressure (39.2% vs 65.4%; p <0.001) and glycosylated hemoglobin (43.9% vs 53.4%; p <0.001) relative to patients without CKD. Only 11.8% of patients with CKD had optimum control of all risk factors. Using multivariate analysis, the presence of CKD was inversely related to the degree of risk-factor control, especially in groups with low GFR. In conclusion, patients with stable coronary heart disease and CKD attended to in primary-care centers had poorer control of coronary heart disease risk factors than those with normal GFR despite receiving a similar rate of prescription of evidence-based cardiovascular disease preventive therapies.
authors.affiliation: Unidad de Arteriosclerosis, Hospital Carlos III, Madrid, Spain. clahoz.hciii@salud.madrid.org
authors.forename: Carlos
authors.initials: C
authors.lastname: Lahoz
authors.forename: Jose M
authors.initials: JM
authors.lastname: Mostaza
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Mantilla
authors.forename: Manuel
authors.initials: M
authors.lastname: Taboada
authors.forename: Salvador
authors.initials: S
authors.lastname: Tranche
authors.forename: Isidro
authors.initials: I
authors.lastname: López-Rodriguez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Monteiro
authors.forename: Begoña
authors.initials: B
authors.lastname: Soler
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanchez-Zamorano
authors.forename: Raquel
authors.initials: R
authors.lastname: Martin-Jadraque
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D008078:Cholesterol, LDL / Q000097:blood; D002908:Chronic Disease; D003327:Coronary Disease / Q000150:complications* / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood; D004232:Diuretics / Q000627:therapeutic use; D004363:Drug Utilization / Q000706:statistics & numerical data; D019317:Evidence-Based Medicine; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006973:Hypertension / Q000517:prevention & control; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011320:Primary Health Care; D012307:Risk Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D008078:Cholesterol, LDL; D004232:Diuretics; D006442:Glycated Hemoglobin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors