title: Stress proteins HSP27 and HSP70i predict survival in non-small cell lung carcinoma.
abstract: BACKGROUND
  The expression pattern of stress (heat shock) proteins (HSPs) in cancer cells is frequently different from that observed in normal cells; most often some stress-inducible HSPs are constitutively and highly expressed. The objective of this study was to determine the prognostic significance of stress proteins HSP70i and HSP27 in non-small cell lung carcinoma (NSCLC).
  
  
  METHODS
  An immunohistochemical procedure that enables unambiguous detection of HSP70i protein was used.
  
  
  RESULTS
  Strong HSP70i staining showed a survival advantage, although multivariate analysis did not confirm this result. There was an evident correlation between HSP27 overexpression and survival of patients and the results were confirmed by multivariate analysis: 70% of patients with HSP27-negative tumors died within one year after the surgery.
  
  
  CONCLUSIONS
  Our data suggest that HSP27 and HSP70i positivity may represent a favorable prognostic factor in NSCLC.
authors.affiliation: Department of Tumor Biology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Branch Gliwice, 44-101 Gliwice, Poland. maluseck@io.gliwice.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Malusecka
authors.forename: Stefania
authors.initials: S
authors.lastname: Krzyzowska-Gruca
authors.forename: Jacek
authors.initials: J
authors.lastname: Gawrychowski
authors.forename: Anna
authors.initials: A
authors.lastname: Fiszer-Kierzkowska
authors.forename: Zofia
authors.initials: Z
authors.lastname: Kolosza
authors.forename: Zdzislaw
authors.initials: Z
authors.lastname: Krawczyk
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D005260:Female; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D018832:Molecular Chaperones; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins