title: Gene regulation: hacking the network on a sugar high.
abstract: In a recent issue of Molecular Cell, Kaplan et al. (2008) determine the input functions for 19 E. coli sugar-utilization genes by using a two-dimensional high-throughput approach. The resulting input-function map reveals that gene network regulation follows non-Boolean, and often nonmonotonic, logic.
authors.affiliation: Center for BioDynamics, Boston University, 44 Cummington Street, Boston, MA 02115, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Ellis
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: James J
authors.initials: JJ
authors.lastname: Collins
mesh_terms: D002241:Carbohydrates; D000242:Cyclic AMP / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D017930:Genes, Reporter; D008128:Logic; D011401:Promoter Regions, Genetic
chemical_list: D002241:Carbohydrates; D000242:Cyclic AMP