title: Polymorphisms of TNF-alpha and LT-alpha genes in multiple myeloma.
abstract: Allelic distribution of -308 G>A (TNF 1/2) polymorphism of the TNF-alpha, and the +252 A>G promoter polymorphism of the LT-alpha gene, the 1267 A>G polymorphism of the HSP70-2 gene as well as the -429 T>C promoter polymorphism of the RAGE gene were tested in 94 MM cases and 141 controls. Significantly less MM patients than controls carried the TNF2 allele (p=0.018) and the TNF2-LTA 252G haplotype (p=0.025). The difference was, however, restricted to the females, as well as the relatively young (<69 years) subjects. By contrast, we did not find differences with the other SNPs tested.
authors.affiliation: Kútvölgyi Clinical Centre, Semmelweis University, Budapest, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kádár
authors.forename: Margit
authors.initials: M
authors.lastname: Kovács
authors.forename: István
authors.initials: I
authors.lastname: Karádi
authors.forename: Béla
authors.initials: B
authors.lastname: Melegh
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Pocsai
authors.forename: Gábor
authors.initials: G
authors.lastname: Mikala
authors.forename: Attila
authors.initials: A
authors.lastname: Tordai
authors.forename: Agnes
authors.initials: A
authors.lastname: Szilágyi
authors.forename: Róza
authors.initials: R
authors.lastname: Adány
authors.forename: George
authors.initials: G
authors.lastname: Füst
authors.forename: Judit
authors.initials: J
authors.lastname: Várkonyi
mesh_terms: D000368:Aged; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha