title: Diffuse large B-cell lymphoma showing an interfollicular pattern of proliferation: a study of the Osaka Lymphoma Study Group.
abstract: OBJECTIVE
  Diffuse large B-cell lymphoma (DLBCL) usually proliferates effacing lymph follicles. In occasional cases, tumour cells show an interfollicular pattern of proliferation preserving lymph follicles. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to determine whether this type of lymphoma is a distinct entity of DLBCL.
  
  
  RESULTS
  Clinicopathological findings in 12 cases of DLBCL showing an interfollicular pattern of proliferation [interfollicular group (IF)] were examined and compared with those in 30 cases of DLBCL with ordinary morphology [control group (CG)]. IF showed a significantly lower lactate dehydrogenase level and International Prognostic Index scores than CG (P = 0.023 and P < 0.01, respectively). The frequency of localized disease, clinical stage 1 and 2, in IF was higher than that in CG (P = 0.016). A morphologically polymorphous pattern of proliferation was found in seven of 12 cases (58.3%) in IF, which was higher than that in CG, five (16.7%) of 30 cases (P < 0.01). Clonality analysis with the polymerase chain reaction method revealed that all 11 IF cases examined showed a monoclonal pattern. Immunohistochemically, the majority (11 of 12) of IF cases showed a non-germinal centre B-cell phenotype and the frequency was higher than that in CG (P = 0.021).
  
  
  CONCLUSIONS
  Diffuse large B-cell lymphoma with an interfollicular pattern of proliferation shows distinct clinical and pathological findings from ordinary DLBCL.
authors.affiliation: Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan. yamauchi@molpath.med.osaka-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Yamauchi
authors.forename: J
authors.initials: J
authors.lastname: Ikeda
authors.forename: I
authors.initials: I
authors.lastname: Nakamichi
authors.forename: M
authors.initials: M
authors.lastname: Kohara
authors.forename: S
authors.initials: S
authors.lastname: Fukuhara
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: Y
authors.initials: Y
authors.lastname: Kanakura
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: A
authors.initials: A
authors.lastname: Kanamaru
authors.forename: K
authors.initials: K
authors.lastname: Aozasa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D049109:Cell Proliferation; D005260:Female; D018858:Germinal Center / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis
chemical_list: D007770:L-Lactate Dehydrogenase