title: Twenty-three novel alleles increase diversity at the HLA-C locus.
abstract: Twenty-three novel HLA-C alleles are described. Nine of the new alleles are single-nucleotide substitutions from their most homologous allele of which seven result in amino acid changes (Cw*0327, *0508, *0514, *0613, *0735, *0739 and *1517) and two are silent substitutions (Cw*030305 and *070107). The remaining 14 alleles (Cw*0113, *0207, *0212, *0216, *0318, *0411, *0417, *0512, *0722, *0733N, *1216, *1218, *1515 and *1607) differ from their most similar alleles by 2-4 nucleotide substitutions that result in 1-3 amino acid differences.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA. poschp@georgetown.edu
authors.forename: A M
authors.initials: AM
authors.lastname: Lazaro
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: K
authors.initials: K
authors.lastname: Cao
authors.forename: C
authors.initials: C
authors.lastname: Masaberg
authors.forename: L
authors.initials: L
authors.lastname: Nichol
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
authors.forename: P E
authors.initials: PE
authors.lastname: Posch
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D040641:Quantitative Trait Loci
chemical_list: D015236:HLA-C Antigens