Prolylcarboxypeptidase: a cardioprotective enzyme.
Prolylcarboxypeptidase (PRCP) is involved in regulating the blood flow through active tissues in order to preserve the internal environment. The expression of PRCP in tissues is determined by a number of pharmacological stimuli such as glucocorticoids and a combination of dexamethasone plus the mu-opioid receptor agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate. PRCP is an enzyme which is associated with preeclampsia, rheumatoid arthritis, and tonsillitis. The interplay between inward cellular signalling required for induced and basal transcription, and PRCP expression have not been mechanistically characterized. Molecules modulated by PRCP include angiotensin II (Ang II), angiotensin III (Ang III), alpha-MSH, and prekallikrein (PK), demonstrating its cardiovascular protective role. In addition to regulating vascular tone, PRCP may modulate proliferation, cell migration, and angiogenesis through regulating angiotensin molecules--and bradykinin--induced endothelium activation. The anti-hypertensive and proinflammatory properties of PRCP implicate that this enzyme may well be an accessible target for anti-inflammatory therapy.
Mallela
J
J
The School of Pharmacy, Department of Pharmacology, University of Mississippi, University, MS 38677-1848, USA. madar@olemiss.edu
Yang
J
J
Shariat-Madar
Z
Z
D001172:Arthritis, Rheumatoid / Q000201:enzymology* / Q000276:immunology; D001779:Blood Coagulation Factors / Q000276:immunology; D002199:Capillary Permeability / Q000276:immunology; D002268:Carboxypeptidases / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D003907:Dexamethasone / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology; D007249:Inflammation; D009479:Neuropeptides / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D011225:Pre-Eclampsia / Q000201:enzymology* / Q000276:immunology; D011247:Pregnancy; D014069:Tonsillitis / Q000201:enzymology* / Q000276:immunology
D001779:Blood Coagulation Factors; D009479:Neuropeptides; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D003907:Dexamethasone; D002268:Carboxypeptidases; C022448:lysosomal Pro-X carboxypeptidase