Peptide YY and neuropeptide Y in the gut: availability, biological actions, and receptors.
Intensive research on the actions of peptide YY(PYY) and neuropeptide Y (NPY) on the gut has been stimulated by findings of potent anti-secretory effects in small intestine and the discovery of their common receptor in this tissue. There is evidence that the hormone PYY and the neurotransmitter NPY are involved in the regulation of fluid and electrolyte secretion, motility, and blood flow in the intestine. Intestinal PYY/NPY receptors may have pharmacological value for the treatment of diarrhea.
Laburthe
M
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Department of Differentiation and Neuroendocrinology of Digestive Cells, Institut National de la Santé et de la Recherche Médicale (INSERM U178), Bâtiment INSERM, Villejuif Cedex, France.