The Bordetella type III secretion system: its application to vaccine development.
B. pertussis is a causative agent of whooping cough (pertussis) in humans. Despite wide-scale vaccination in many countries, there is serious concern about pertussis as a re-emerging disease. Re-emergence of pertussis may be explained by several factors: the short duration of protection by the currently available acellular pertussis vaccine, an increase in asymptomatic adult carriers and expansion of strains with certain antigenic variations which are not covered by currently available vaccines. To develop safer and more efficacious vaccines which confer more prolonged protection, researchers are focusing on identification and characterization of new virulence factors. One candidate for protective antigens is the type III secretion system and its secreted proteins.
Abe
Akio
A
Laboratory of Bacterial Infection, Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, Tokyo, Japan. abe@lisci.kitasato-u.ac.jp
Nagamatsu
Kanna
K
Watanabe
Mineo
M
D001426:Bacterial Proteins / Q000502:physiology*; D001886:Bordetella pertussis / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D010567:Pertussis Vaccine / Q000276:immunology; D037521:Virulence Factors / Q000502:physiology*; D014917:Whooping Cough / Q000453:epidemiology
D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D010567:Pertussis Vaccine; D037521:Virulence Factors