The androgen receptor as mediator of gene expression and signal transduction pathways.
The current model of action of androgens involves activation of a cytoplasmic receptor that migrates into the nucleus to regulate the expression of specific genes, either positively or negatively. While positive regulation requires direct binding of the receptor to DNA, negative regulation occurs mainly through protein-protein interactions of the receptor and other transcription factors. More recent findings have shown that the receptor also mediates non-conventional responses attributed hitherto only to activated growth factor receptors. These actions proceed principally through activation of cytoplasmic kinases and they suggest that in addition to its genomic functions, the androgen receptor also regulates non-genomic processes.
Cato
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Forschungszentrum Karlsruhe, Institut für Genetik, Postfach 3640, D-76021 Karlsruhe, Germany.
Peterziel
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