title: Preparation and phytotoxicity of novel kaurane diterpene amides with potential use as herbicides.
abstract: Novel kaurane ditepene monoamides were synthesized in good yields directly from kaurenoic ( 1) and grandiflorenic ( 2) acids and unprotected symmetrical diamines, using a modified protocol for monoacylation. Amides from 1 and 2 and monoamines were also obtained and tested against seed germination and growth of radicle and shoot of Lactuca sativa (lettuce), at 10 (-3), 10 (-5), and 10 (-7) M. Amides from symmetrical diamines showed significant inhibitory activity at higher concentrations.
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil. dianadb@netuno.lcc.ufmg.br
authors.forename: Maria Amélia Diamantino
authors.initials: MA
authors.lastname: Boaventura
authors.forename: Rondinelle Gomes
authors.initials: RG
authors.lastname: Pereira
authors.forename: Luiza B
authors.initials: LB
authors.lastname: de Oliveira Freitas
authors.forename: Leandro Alves
authors.initials: LA
authors.lastname: Dos Reis
authors.forename: Henriete
authors.initials: H
authors.lastname: da Silva Vieira
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry; D045786:Diterpenes, Kaurane / Q000138:chemical synthesis* / Q000494:pharmacology*; D018525:Germination / Q000187:drug effects; D006540:Herbicides / Q000494:pharmacology*; D018545:Lactuca / Q000187:drug effects / Q000254:growth & development; D018520:Plant Shoots / Q000187:drug effects / Q000254:growth & development; D010944:Plants / Q000187:drug effects*
chemical_list: D000577:Amides; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D006540:Herbicides; C014576:grandiflorenic acid; C051436:kaurenoic acid