Assessment of aortic pulse wave velocity and cardiac diastolic function in subjects with and without the metabolic syndrome: HDL cholesterol is independently associated with cardiovascular function.
OBJECTIVE
To evaluate the influence of lipid and glucose metabolism in the metabolic syndrome on aortic pulse wave velocity (PWV) and left ventricular (LV) diastolic function using magnetic resonance imaging (MRI).


METHODS
Aortic PWV and LV diastolic function were assessed using MRI in 16 subjects with the metabolic syndrome and 16 subjects without the metabolic syndrome matched for age, waist circumference, and blood pressure. The groups were compared using the unpaired t test or Mann-Whitney U test, and linear regression analysis was applied.


RESULTS
Aortic PWV was increased and LV diastolic function was decreased in subjects with compared with those without the metabolic syndrome. HDL cholesterol was independently associated with aortic PWV (R = -0.470, P < 0.01) and LV diastolic function (R = -0.421, P = 0.02).


CONCLUSIONS
Increased aortic PWV and decreased LV diastolic function is observed in subjects with the metabolic syndrome, regardless of blood pressure. Moreover, HDL cholesterol is independently associated with aortic PWV and LV diastolic function.
Roes
Stijntje D
SD
Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. s.d.roes@lumc.nl
Alizadeh Dehnavi
Reza
R
Westenberg
Jos J M
JJ
Lamb
Hildo J
HJ
Mertens
Bart J A
BJ
Tamsma
Jouke T
JT
de Roos
Albert
A
D000368:Aged; D001011:Aorta / Q000502:physiology* / Q000503:physiopathology; D001783:Blood Flow Velocity; D008076:Cholesterol, HDL / Q000097:blood*; D003971:Diastole / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D011674:Pulse; D012016:Reference Values; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
D008076:Cholesterol, HDL