title: Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?
abstract: The way in which estrogen receptor alpha (ERalpha) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERalpha-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERalpha17p), we propose that ERalpha proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERalpha activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.
authors.affiliation: Laboratoire J.-C. Heuson de Cancérologie Mammaire, Université Libre de Bruxelles (ULB), Institut Jules Bordet, Brussels, Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Gallo
authors.forename: Iman
authors.initials: I
authors.lastname: Haddad
authors.forename: Guy
authors.initials: G
authors.lastname: Laurent
authors.forename: Joëlle
authors.initials: J
authors.lastname: Vinh
authors.forename: Françoise
authors.initials: F
authors.lastname: Jacquemotte
authors.forename: Yves
authors.initials: Y
authors.lastname: Jacquot
authors.forename: Guy
authors.initials: G
authors.lastname: Leclercq
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D047628:Estrogen Receptor alpha / Q000737:chemistry / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010455:Peptides / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology*
chemical_list: D047628:Estrogen Receptor alpha; D004967:Estrogens; D010455:Peptides; D046988:Proteasome Endopeptidase Complex