[Analysis and evaluation of S-phenylmercapturic acid as a biomarker for benzene exposure].
Since urinary S-phenylmercapturic acid concentration could be well related to benzene exposure, it could be a sensitive and specific biomarker of low-level benzene exposure. SPMA may be determined by HPLC, LC/MS, GC/MS and ELISA methods. The abroad methods of determination of urinary SPMA were reviewed in detail in recently years and the validation and application of urinary SPMA as a biomarker for occupation benzene exposure were evaluated.
Luo
Qiao
Q
Department of Occupational Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. luoqiao82@gmail.com
Zhu
Changcai
C
Song
Shizhen
S
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D001554:Benzene / Q000378:metabolism* / Q000633:toxicity; D015415:Biomarkers / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid / Q000379:methods; D004781:Environmental Exposure / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis*
D015415:Biomarkers; C053003:S-phenyl-N-acetylcysteine; D001554:Benzene; D000111:Acetylcysteine