Both the hippocampus and striatum are involved in consolidation of motor sequence memory.
Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.
Albouy
Geneviève
G
Cyclotron Research Centre, University of Liège, B-4000 Liège, Belgium.
Sterpenich
Virginie
V
Balteau
Evelyne
E
Vandewalle
Gilles
G
Desseilles
Martin
M
Dang-Vu
Thanh
T
Darsaud
Annabelle
A
Ruby
Perrine
P
Luppi
Pierre-Hervé
PH
Degueldre
Christian
C
Peigneux
Philippe
P
Luxen
André
A
Maquet
Pierre
P
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D003342:Corpus Striatum / Q000098:blood supply / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology* / Q000528:radiation effects*; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology; D012691:Serial Learning / Q000502:physiology*; D013647:Task Performance and Analysis
D010100:Oxygen