title: Auditory neuropathy in a patient exposed to xylene: case report.
abstract: OBJECTIVE
  To report the case of an adult patient who developed auditory complaints following xylene exposure, and to review the literature on the effects of solvent exposure on hearing.
  
  
  METHODS
  The patient presented with a gradual deterioration in his ability to hear in difficult acoustic environments and also to hear complex sounds such as music, over a 40-year period. His symptoms began following exposure to the solvent xylene, and in the absence of any other risk factor. Our audiological investigations revealed normal otoacoustic emissions with absent auditory brainstem responses and absent acoustic reflexes in both ears, consistent with a diagnosis of bilateral auditory neuropathy. Central test results were also abnormal, indicating possible involvement of the central auditory pathway.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of retrocochlear hearing loss following xylene exposure. The test results may provide some insight into the effect of xylene as an isolated agent on the human auditory pathway.
authors.affiliation: Audiology Department, Royal Sussex County Hospital, Brighton, UK. tracy.draper@bsuh.nhs.uk
authors.forename: T H J
authors.initials: TH
authors.lastname: Draper
authors.forename: D-E
authors.initials: DE
authors.lastname: Bamiou
mesh_terms: D001301:Audiometry, Pure-Tone; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012181:Retrocochlear Diseases / Q000139:chemically induced*; D012997:Solvents / Q000633:toxicity*; D014992:Xylenes / Q000633:toxicity*
chemical_list: D012997:Solvents; D014992:Xylenes