title: Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.
abstract: Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ishiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Araki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Mikami
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; C530730:petiolin A; C530731:petiolin B; C530732:petiolin C; D010696:Phloroglucinol