Renal pathology of ANCA-related vasculitis: proposal for standardization of pathological diagnosis in Japan.
BACKGROUND
In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Group (EUVAS) classification. Therefore, a histological common basis is needed to compare Japanese histological data with the international database.


METHODS
Histological parameters concerning glomerular, tubulointerstitial, and vascular lesions of ANCA-related vasculitis, which are indispensable for clinical management, were elucidated and defined by reviewing, utilizing the merits of, and amending the two scoring systems.


CONCLUSIONS
A new comprehensive and standardized scoring system, by which histological quantitative assessment can provide evidence for therapy planning, has been developed for renal biopsy of Japanese ANCA-related vasculitis.
Joh
Kensuke
K
Division of Renal Pathology, Clinical Research Center, Chiba-East National Hospital, Chiba, Japan. johken@cehprinet.com.
Muso
Eri
E
Division of Nephrology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan.
Shigematsu
Hidekazu
H
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Nose
Masato
M
Department of Pathogenomics, Ehime University Graduate School of Medicine, Ehime, Japan.
Nagata
Michio
M
Department of Molecular Pathology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Arimura
Yoshihiro
Y
First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Yumura
Wako
W
Department of Nephrology and Kidney Center, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Wada
Takashi
T
Department of Laboratory Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Nitta
Kousaku
K
Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Makino
Hirofumi
H
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Taguma
Yoshio
Y
Department of Nephrology, Sendai Shakaihoken Hospital, Miyagi, Japan.
Kaneoka
Hidetoshi
H
Department of Medical Nursing, Fukuoka University School of Nursing, Fukuoka, Japan.
Suzuki
Yuhsuke
Y
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Kobayashi
Masaki
M
Department of Internal Medicine, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan.
Koyama
Akio
A
Ibaraki Prefectural University of Health Science, Ibaraki, Japan.
Usui
Joichi
J
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Hashimoto
Hiroshi
H
Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Ozaki
Shoichi
S
Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
Tomino
Yasuhiko
Y
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Yamagata
Kunihiro
K
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D001706:Biopsy; D019937:Diagnostic Techniques and Procedures / Q000592:standards*; D005060:Europe; D006801:Humans; D007564:Japan; D007668:Kidney / Q000473:pathology*; D014657:Vasculitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic