title: Proteome of human minor salivary gland secretion.
abstract: Recent research efforts in oral biology have resulted in elucidation of the proteomes of major human salivary secretions and whole saliva. One might hypothesize that the proteome of minor gland secretions may show significantly different characteristics when compared with the proteomes of parotid or submandibular/sublingual secretions. To test this hypothesis, we conducted the first exploration into the proteome of minor salivary gland secretion. Minor gland secretion was obtained from healthy volunteers, and its components were subjected to liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry. This led to the identification of 56 proteins, 12 of which had never been identified in any salivary secretion. The unique characteristics of the minor salivary gland secretion proteome are related to the types as well as the numbers of components present. The differences between salivary proteomes may be important with respect to specific oral functions.
authors.affiliation: Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, CABR, Suite W-201, Boston, MA 02118, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Siqueira
authors.forename: E
authors.initials: E
authors.lastname: Salih
authors.forename: D L
authors.initials: DL
authors.lastname: Wan
authors.forename: E J
authors.initials: EJ
authors.lastname: Helmerhorst
authors.forename: F G
authors.initials: FG
authors.lastname: Oppenheim
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods; D012016:Reference Values; D012470:Salivary Glands, Minor / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000145:classification / Q000378:metabolism
chemical_list: D020543:Proteome; D012471:Salivary Proteins and Peptides