Pharmacokinetics and tissue distribution of anidulafungin in rats.
This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.
Damle
Bharat
B
Pfizer Inc., New York, New York 10017, USA. bharat.damle@pfizer.com
Stogniew
Martin
M
Dowell
James
J
D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001345:Autoradiography; D002177:Candidiasis / Q000188:drug therapy / Q000378:metabolism; D002250:Carbon Radioisotopes; D054714:Echinocandins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D000935:Antifungal Agents; D002250:Carbon Radioisotopes; D054714:Echinocandins; D000077612:Anidulafungin