title: Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction.
abstract: Dysfunctions affecting the connections of basal ganglia lead to major neurological and psychiatric disorders. We investigated levels of mRNA for three neurexins (Nrxn) and three neuroligins (Nlgn) in the globus pallidus, subthalamic nucleus, and substantia nigra, in control conditions and after short-term exposure to cocaine. The expression of Nrxn2beta and Nlgn3 in the substantia nigra and Nlgn1 in the subthalamic nucleus depended on genetic background. The development of short-term cocaine appetence induced an increase in Nrxn3beta expression in the globus pallidus. Human NRXN3 has recently been linked to several addictions. Thus, NRXN3 adhesion molecules may play an important role in the synaptic plasticity of neurons involved in the indirect pathways of basal ganglia, in which they regulate reward-related learning.
authors.affiliation: INSERM U675, School of Medicine Xavier Bichat, University Denis Diderot, Paris VII, France.
authors.forename: Sabah
authors.initials: S
authors.lastname: Kelai
authors.forename: Gilles
authors.initials: G
authors.lastname: Maussion
authors.forename: Florence
authors.initials: F
authors.lastname: Noble
authors.forename: Claudette
authors.initials: C
authors.lastname: Boni
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ramoz
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Moalic
authors.forename: Michel
authors.initials: M
authors.lastname: Peuchmaur
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
authors.forename: Michel
authors.initials: M
authors.lastname: Simonneau
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal; D003042:Cocaine / Q000009:adverse effects; D019970:Cocaine-Related Disorders / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000009:adverse effects; D015870:Gene Expression; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism*; D007834:Lasers; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D042282:Microdissection; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000187:drug effects; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D018765:Dopamine Uptake Inhibitors; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; D012333:RNA, Messenger; C093438:neuroligin 1; C098004:neuroligin 3; D003042:Cocaine