title: Right hemisphere involvement in non-fluent primary progressive aphasia.
abstract: We described a 56-years-old man with a diagnosis of "non-fluent primary progressive aphasia" (NfPPA). An accurate neuropsychological, neurological and neuroimaging evaluation was performed in order to assess clinical and behavioural features of the patient. From a neuropsychological point of view, the patient showed a typical cognitive profile of subjects affected by NfPPA: a prominent language deficit, associated with impairments in several cognitive domains after three years from the onset of the symptomatology. The most intriguing feature is that SPECT revealed hypoperfusion in the right frontal cortex, albeit the patient is right-handed. This unexpected finding shows that NfPPA may arise not only from cortical abnormalities in the language-dominant left hemisphere, but also from right hemisphere involvement in a right hander (crossed aphasia).
authors.affiliation: IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. claudia.repetto@cognitiveneuroscience.it
authors.forename: Claudia
authors.initials: C
authors.lastname: Repetto
authors.forename: Rosa
authors.initials: R
authors.lastname: Manenti
authors.forename: Maria
authors.initials: M
authors.lastname: Cotelli
authors.forename: Marco
authors.initials: M
authors.lastname: Calabria
authors.forename: Orazio
authors.initials: O
authors.lastname: Zanetti
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.forename: Carlo
authors.initials: C
authors.lastname: Miniussi
mesh_terms: D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000473:pathology*; D005625:Frontal Lobe / Q000098:blood supply / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015899:Tomography, Emission-Computed, Single-Photon