The diagnostic role of serum inflammatory and soluble proteins on dementia subtypes: correlation with cognitive and functional decline.
In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer's disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1beta, IL-2, IL-6, IL-18, TNF-alpha, beta-Amlyloid 1-40 and alpha1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of alpha1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1beta and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.
Oztürk
Candan
C
Mersin University School of Medicine and Mersin University School of Science and Letters, Mersin, Turkey.
Ozge
Aynur
A
Yalin
Osman Ozgür
OO
Yilmaz
I Arda
IA
Delialioglu
Nuran
N
Yildiz
Cilem
C
Tesdelen
Bahar
B
Kudiaki
Cigdem
C
D000209:Acute-Phase Proteins / Q000032:analysis* / Q000276:immunology; D000368:Aged; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000276:immunology; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood* / Q000145:classification; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood* / Q000276:immunology; D012016:Reference Values; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000209:Acute-Phase Proteins; D016229:Amyloid beta-Peptides; D015415:Biomarkers; D007378:Interleukins; D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; C078592:amyloid beta-protein (1-40)