Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract.
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
Cho
Dae Sung
DS
Department of Urology, Ajou University School of Medicine, San-5 Wonchon-dong, Yeongtong-gu, Suwon, Korea.
Yim
Hyunee
H
Cho
Kang Su
KS
Hong
Sung Joon
SJ
Cho
Nam Hoon
NH
Kim
Sun Il
SI
Ahn
Hyun Soo
HS
Kim
Se Joong
SJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000378:metabolism*; D051242:Caveolin 1 / Q000096:biosynthesis*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
D051242:Caveolin 1