Severe autoimmune hemolytic anemia in a liver transplanted child.
AIHA can complicate solid organ and bone marrow transplantation early after transplant. We describe the first case report of a 16-month-old boy with mixed type warm-acting IgM and warm IgG autoantibodies AIHA, occurring eight months after liver transplantation. This case describes the complexity of this very rare form of AIHA. It also illustrates the efficacy of rituximab in this indication, as well as the transfusion support with extremely rare blood, along with the importance of international collaboration to provide it. In this report, the etiologies of HA occurring in post-transplant pediatric patients are reviewed and the different treatment strategies are discussed.
Schäppi
Michela G
MG
Division of Paediatric Gastroenterology and Transplantation, Children's Hospital of Geneva, Geneva, Switzerland. michela.schaeppi@hcuge.ch
Ozsahin
Hulya
H
Peyrard
Thierry
T
Gumy-Pause
Fabienne
F
Posfay-Barbe
Klara M
KM
Chardot
Christophe
C
Belli
Dominique C
DC
Siegenthaler
Michèle A
MA
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000209:etiology*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000737:chemistry; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies / Q000737:chemistry; D001803:Blood Transfusion; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D007075:Immunoglobulin M / Q000737:chemistry; D007155:Immunologic Factors / Q000008:administration & dosage; D007223:Infant; D008107:Liver Diseases / Q000150:complications*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods*; D008297:Male; D000069283:Rituximab
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007155:Immunologic Factors; D000069283:Rituximab