[A comparative study of leptin content in diabetics and obese subjects].
OBJECTIVE
To compare leptin content in morphologically heterogenic group of patients with type 2 diabetes mellitus and obese patients without family history of diabetes.


METHODS
Leptin concentration was estimated with enzyme immunoassay (Leptin kit Sandwish ELISA, DRG diagnostics GmdH) in 21 patients with type 2 diabetes mellitus (2DM) and 12 obese patients without family history of diabetes. Distribution of patients with a documented diagnosis type 2 diabetes mellitus was conducted with application of instruments for antropometric examination (G.P. Gneupel, Switzerland). Statistic processing was made with the program Statistica 6 using Student's t-criterion.


RESULTS
Patients with diabetes mellitus and phenotypical marker of 2DM had the lowest level of leptin (mean leptin level 1.99 ng/ml in males, 11.01 ng/ml in females versus 2DM patients without the marker (mean leptin level 9.16 n/mg in males, 23.56 n/mg in females) and control group (13.86 ng/ ml in males, 22.55 ng/ml in females).


CONCLUSIONS
There is a correlation between leptin concentration and anthropological features of the patients.
Sokolova
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Babadzhanova
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D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers; D020738:Leptin