title: Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth.
abstract: Premature birth before 37 weeks of gestation is a significant public health problem. Each year, 4.5 million premature infants are born worldwide. Despite extensive research and a variety of interventions, the rate of preterm birth has steadily increased over the past 20 years and reached a high of 12.8% in 2006. The etiology of most preterm births remains elusive and is likely multifactorial, with many pathophysiological pathways involved, such as excessive stretching, oxidative stress, decidual hemorrhage, and infection. Genomics and proteomics have emerged to provide a better comprehension of the pathophysiological conditions leading to preterm birth, thereby providing a perspective for improving neonatal outcome.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Catalin S
authors.initials: CS
authors.lastname: Buhimschi
authors.forename: Victor A
authors.initials: VA
authors.lastname: Rosenberg
authors.forename: Antonette T
authors.initials: AT
authors.lastname: Dulay
authors.forename: Stephen
authors.initials: S
authors.lastname: Thung
authors.forename: Anna K
authors.initials: AK
authors.lastname: Sfakianaki
authors.forename: Mert-Ozan
authors.initials: MO
authors.lastname: Bahtiyar
authors.forename: Irina A
authors.initials: IA
authors.lastname: Buhimschi
mesh_terms: D002582:Cervix Mucus / Q000502:physiology; D002821:Chorioamnionitis / Q000235:genetics; D003656:Decidua / Q000502:physiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000235:genetics; D053263:Gene Regulatory Networks; D005819:Genetic Markers; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D047928:Premature Birth / Q000235:genetics*; D040901:Proteomics; D049490:Systems Biology / Q000379:methods*; D014621:Vagina / Q000378:metabolism
chemical_list: D005819:Genetic Markers