Urinary leukotrienes in patients with nasal polyposis.
OBJECTIVE
To compare urinary leukotriene E4 (ULT) level in patients with nasal polyposis (NP) with and without aspirin intolerance and allergic rhinitis (AR), and correlate it with disease severity.


METHODS
Prospective study from November 2005 to November 2006. Patients with NP (n = 30) and AR (n = 35) were included. The concentration of ULT was measured in both groups. Oral provocation test with aspirin was performed to patients with NP. ULT level between both groups was compared and correlated with NP disease severity.


RESULTS
ULT concentration was elevated on NP and AR. The patients with NP and aspirin intolerance (n = 4) presented higher levels of ULT compared to aspirin-tolerant patients. Leukotriene concentration was not correlated with NP severity.


CONCLUSIONS
Patients with NP and aspirin intolerance have increased ULT excretion; thus their measurement can be used as an indicator of arachidonic acid metabolism alteration.
Royer
Michel
M
Department of Otolaryngology, Head and Neck Surgery, Hospital Clínico Universidad de Chile, Santiago, Chile. nazorej@yahoo.com
Guzmán
María Antonieta
MA
Gormaz
Juan-Pablo
JP
Nazar
Gonzalo
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017999:Leukotriene E4 / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000652:urine*; D011446:Prospective Studies
D017999:Leukotriene E4