[State of vasoregulative function of vascular endothelium and cardiohemodynamics in patients with chronic obstructive diseases of the lung (CODL) treated with losartan].
The authors studied the influence of lozartan -angiotensin II antagonist on the state of cardiohemodynamics and function of vessel endothelial cell in patients with CODL in the process of the treatment. 90 patients with stage II or III CODL in remission (average age is 50.46+/-5.1) have been observed. The average duration of the disease was 16.2+/-7.6 years. 30 patients received additionally lozartan -angiotensin II antagonist. Cardiohemodynamics has been assessed using Doppler ultrasonography. To assess the state of function of vessel endothelial cell the authors carried out reactive hyperemia test and calculated the level of nitrite nitrogen in blood plasma and erythrocytes. The duration of observation was 12 weeks. Losartan appeared to be effective in patients with CODL to correct compromised cardiohemodynamics. Losartan dicreases the disfunction of endothelial cell and has cardioprotective properties.
Rodionova
V V
VV
Lysenko
A O
AO
Ruchko
V I
VI
Lysenko
O A
OA
D000328:Adult; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D004452:Echocardiography; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D019808:Losartan / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D012119:Respiration / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D047228:Angiotensin II Type 1 Receptor Blockers; D009569:Nitric Oxide; D019808:Losartan