title: Association study on glutathione S-transferase omega 1 and 2 and familial ALS.
abstract: Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this study 12 Hapmap tagged SNPs in GSTO1 and 2 were genotyped in 251 Caucasian British, Australian and Swedish familial ALS (FALS) cases. No association was found for age of onset and survival of FALS in the British and Australian patients. In the Swedish patients, association for age of onset was found with several SNPs (p = 0.003-0.048). These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS.
authors.affiliation: Department of Neurology, Institute of Psychiatry, King's College London, London, UK. elsmarieke@gmail.com
authors.forename: Elsmarieke
authors.initials: E
authors.lastname: van de Giessen
authors.forename: Isabella
authors.initials: I
authors.lastname: Fogh
authors.forename: Sumana
authors.initials: S
authors.lastname: Gopinath
authors.forename: Bradley
authors.initials: B
authors.lastname: Smith
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
authors.forename: John
authors.initials: J
authors.lastname: Powell
authors.forename: Peter
authors.initials: P
authors.lastname: Andersen
authors.forename: Garth
authors.initials: G
authors.lastname: Nicholson
authors.forename: Ammar
authors.initials: A
authors.lastname: Al Chalabi
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Shaw
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: C490476:GSTO1 protein, human; C492569:GSTO2 protein, human; D005982:Glutathione Transferase