Highly similar noncoding genomic DNA sequences: ultraconserved, or merely widespread?
In this note, I propose an explanation for the seeming contradiction between bioinformatics-based predictions of an essential function for ultraconserved DNA sequences, and the lack of an experimental demonstration of such function.
Hickey
Donal A
DA
Department of Biology, Concordia University, Montreal, QC, Canada. dhickey@alcor.concordia.ca
D001483:Base Sequence; D019295:Computational Biology / Q000379:methods; D017124:Conserved Sequence / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics*; D021901:DNA, Intergenic; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data
D004251:DNA Transposable Elements; D021901:DNA, Intergenic