Pedigree selection and information content.
This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis. It includes methods for determining the power of a dataset to detect genetic loci for both model-based (lod score) and model-free (affected sib-pair, affected-relative pair) analyses. This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis.
Hauser
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Duke University Medical Center, Durham, North Carolina, USA.
Weeks
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D019295:Computational Biology; D005260:Female; D008040:Genetic Linkage; D005821:Genetic Techniques; D005826:Genetics, Medical; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree