title: Modified egg composition to reduce low-density lipoprotein oxidizability: high monounsaturated fatty acids and antioxidants versus regular high n-6 polyunsaturated fatty acids.
abstract: Eggs high in n-6 PUFA, predominant in Western markets, were found to increase blood LDL oxidation, suggesting a new health concern beyond raising cholesterol. Protective composition was explored by increasing egg antioxidants and MUFA and reducing n-6 PUFA. Lag times to plasma LDL oxidation were significantly shortened with two eggs/day of high-PUFA compositions compared to a low-egg (2-4/week) regime, by 28.8% following "HPUFA-regular" ( p < 0.01) and by 27.2% following antioxidant-fortified "HPUFA-HAOX" ( p < 0.01). However, two "HMUFA-HAOX" eggs/day with reduced egg n-6 PUFA FA% (LA by 30.7%) and PUFA:MUFA ratio (LA:OA by 45.8%) plus increased antioxidants (vitamin E 500%, carotenoids 260%), resulting in increased plasma OA 33.3%, vitamin E 22.4%, and carotenoids 55.0% ( p < 0.01), were associated with lag-time only 6.6% shorter than low-egg (NS). Among health-oriented egg modifications, here for the first time they reduced associated LDL oxidization, consistent with anti-inflammation and antioxidant paradigms, warranting further research on functional advantages of antioxidative egg composition.
authors.affiliation: Stanley Steyer School of Health Professions, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. nivnet@inter.net.il
authors.forename: Niva
authors.initials: N
authors.lastname: Shapira
authors.forename: Joseph
authors.initials: J
authors.lastname: Pinchasov
mesh_terms: D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D002338:Carotenoids / Q000097:blood; D004032:Diet; D004531:Eggs / Q000032:analysis*; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D006801:Humans; D007557:Israel; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D005229:Fatty Acids, Monounsaturated; D043371:Fatty Acids, Omega-6; D008077:Lipoproteins, LDL; D019301:Oleic Acid; D002338:Carotenoids