Antifungal activity of crude extracts and fat-soluble constituents of Holotrichia diomphalia larvae.
In this study, chemical compositions of fatty oils and bioactivity of crude extracts from Holotrichia diomphalia larvae as Chinese materia medica were investigated for the first time. The chemical compositions of the fatty oils were obtained by two different methods and determined by GC/MS. In total, the petroleum ether extract produced 21 compounds (96.3%) while the supercritical fluid extract produced six compounds (99.53%) for identification. The effect of petroleum ether and other crude extracts on Pyricularia oryzae was also examined. Results indicated that ethanol and petroleum ether extracts had excellent antifungal activities. These findings demonstrated that fatty oils from H. diomphalia larvae had great potential to be used as a source for natural health products.
Dong
Qing-Feng
QF
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, GuoHe Road 325, Shanghai 200433, PR China.
Wang
Jun-Lan
JL
Zhang
Shu-Feng
SF
Wang
Zhi
Z
Zhang
Chong-Xi
CX
Gao
He
H
Zhang
Han-Ming
HM
Zhang
Lei
L
D000473:Alkanes / Q000737:chemistry; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D025924:Chromatography, Supercritical Fluid; D001517:Coleoptera / Q000737:chemistry*; D045424:Complex Mixtures / Q000494:pharmacology*; D005223:Fats / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007814:Larva / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009821:Oils / Q000737:chemistry; D012995:Solubility / Q000187:drug effects
D000473:Alkanes; D000935:Antifungal Agents; D045424:Complex Mixtures; D005223:Fats; D009821:Oils; C004544:naphtha