title: The underlying mechanisms for development of hypertension in the metabolic syndrome.
abstract: High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.
authors.affiliation: Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan. yanaih@jikei.ac.jp
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Yanai
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Tomono
authors.forename: Kumie
authors.initials: K
authors.lastname: Ito
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Furutani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Norio
authors.initials: N
authors.lastname: Tada
mesh_terms: D015897:Comorbidity; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology*; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D018384:Oxidative Stress; D012084:Renin-Angiotensin System; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000453:epidemiology; D013564:Sympathetic Nervous System / Q000503:physiopathology