title: Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.
abstract: Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008.
authors.affiliation: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
authors.forename: Mei-Ching
authors.initials: MC
authors.lastname: Lee
authors.forename: Manabu
authors.initials: M
authors.lastname: Funayama
authors.forename: Meng-Ling
authors.initials: ML
authors.lastname: Chen
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Soto
authors.forename: Ignacio F
authors.initials: IF
authors.lastname: Mata
authors.forename: Guey-Jen
authors.initials: GJ
authors.lastname: Lee-Chen
authors.forename: Chiung Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: Michelle
authors.initials: M
authors.lastname: Tang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Eng-King
authors.initials: EK
authors.lastname: Tan
authors.forename: Ruey-Meei
authors.initials: RM
authors.lastname: Wu
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D018703:Founder Effect; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012846:Singapore / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology
chemical_list: D005819:Genetic Markers; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases