[Control of neural cell migration during the development of the central nervous system].
During the embryonic development, neurons migrate from their origin to their final position. Control of neuronal migrations is critical for formation of the complex architecture of the central nervous system. In the developing central nervous system, there are two major patterns of neuronal migrations. One is radial migration and the other is tangential migration. In radial migration, migrating cells move along radial fibers that are processes of radial glial cells. Contact between radial glial cells and migrating cells has been supposed to control radial migration. In tangential migration, some tracts of neuronal migrations are controlled by chemokines. Neuronal migration utilizes its own migratory strategies, such as cell-cell contact with radial glial cells as well as common principles of cell migration like chemoattractants. As cell migrations reflect cytoskeletal changes in the cells, external cues like chemoattractants and cell adhesion finally influence the structure of cytoskeleton in migrating neurons. We summarize previous studies on cell migration and discuss specific mechanisms of neural migration in this review.
Yagi
Hideshi
H
Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshidagun, Fukui 910-1193, Japan.
Sato
Makoto
M
D051376:Actin-Related Protein 2-3 Complex / Q000502:physiology; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000196:embryology*; D002448:Cell Adhesion / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D002465:Cell Movement / Q000235:genetics* / Q000502:physiology*; D016764:Cell Polarity / Q000235:genetics / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D002630:Chemotactic Factors / Q000502:physiology; D003285:Contractile Proteins / Q000502:physiology; D003599:Cytoskeleton; D016326:Extracellular Matrix Proteins / Q000502:physiology; D064448:Filamins; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D054082:Lissencephaly / Q000235:genetics; D008840:Microfilament Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009457:Neuroglia; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D051376:Actin-Related Protein 2-3 Complex; D015816:Cell Adhesion Molecules, Neuronal; D018925:Chemokines; D002630:Chemotactic Factors; D003285:Contractile Proteins; D016326:Extracellular Matrix Proteins; D064448:Filamins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D012697:Serine Endopeptidases