[Experimental research about the effect of Rehmannia glutinosa on the drug effect fingerprints of the rabbit's blood serum of Yin deficiency and heat flourishing syndrome].
OBJECTIVE
To study about the effect of Rehmannia glutinosa Libosch on the drug effect fingerprints of the rabbit's blood serum of yin deficiency and heat flourishing syndrome.


METHODS
The infusion of furosemide and escherichia coli endotoxin were used to replicate rabbit' s yin deficiency and heat flourishing syndrome animal model; high performance liquid chromatography gradient elution was adopped to study the change of the rabbit serum drug effect fingerprint in copying between before and after model-making and administration.


RESULTS
Rehmannia glutinosa Libosch mainly affected metabolism level of the inner substance with the function of nourishing yin clearing heat.


CONCLUSIONS
The serum HPLC fingerprint established is capable to reflect the function of nourishing yin clearing heat of Rehmannia glutinosa Libosch; the further study on its drug effect fingerprint will help to clarify its activity and metabolism of action.
Feng
Zhi-yi
ZY
School of Chinese Materia Medica, Beijing University of TCM, Beijing 100102, China.
Cui
Ying
Y
Ding
Gang
G
Zhang
Bing
B
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004731:Endotoxins; D005260:Female; D005665:Furosemide; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D032267:Rehmannia / Q000737:chemistry; D016710:Yin Deficiency / Q000097:blood* / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D005665:Furosemide