The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C.
Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.
Davis
Rohan A
RA
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Qld 4111, Australia. r.davis@griffith.edu.au
Longden
James
J
Avery
Vicky M
VM
Healy
Peter C
PC
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D032641:Eurotiales / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010407:Penicillium / Q000737:chemistry*; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D004151:Dipeptides; D004224:Diterpenes; C529906:trichodermamide C