title: Thermo-triggered and biotinylated biotin-P(NIPAAm-co-HMAAm)-b-PMMA micelles for controlled drug release.
abstract: Thermosensitive and biotinylated biotin-poly (N-isopropylacrylamide-co-N-hydroxymethylacrylamide)-block-poly(methyl methacrylate) (biotin-P(NIPAAm-co-HMAAm)-b-PMMA) block copolymers were designed and synthesized. The conjugation of biotin molecule with the copolymer as well as the capability of easily functionalizing with ligands for pretargeting approach of the biotinylated multifunctional drug carrier was confirmed by a novel method called capillary electrophoresis immunoassay (CEIA) based on enhanced chemiluminescence (CL) detection. The biotin-P(NIPAAm-co-HMAAm)-b-PMMA copolymer was capable of self-assembling into nanometer-sized micelle. The anticancer drug methotrexate (MTX), used as a model drug, was loaded in the self-assembled micelles and the thermo-triggered release behavior of MTX was investigated.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Si-Xue
authors.initials: SX
authors.lastname: Cheng
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry; D001710:Biotin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000737:chemistry; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D008823:Micelles; D012996:Solutions; C539100:biotin-poly(N-isopropylacylamide-co-N-hydroxymethylacrylamide)-block-poly(methyl methacrylate); D001710:Biotin; D019904:Polymethyl Methacrylate; D008727:Methotrexate