Human T-cell leukemia virus type I-associated myelopathy following living-donor liver transplantation.
This report describes a patient who developed human T-cell leukemia virus type I-associated myelopathy (HAM) following a living-donor liver transplantation (LDLT) for liver cirrhosis due to hepatitis C virus (HCV) infection. Both the recipient and the living donor (his sister) were human T-cell leukemia virus type I (HTLV-I) carriers. Since the LDLT, he had been treated with immunosuppressive drugs such as tacrolimus and steroids as well as interferon-alpha to prevent rejection and a recurrence of the HCV infection, respectively. Even though the HTLV-I proviral load had decreased upon interferon treatment, he developed a slowly progressive gait disturbance with urinary disturbance 2 years after the LDLT and was diagnosed with HAM. This appears to be the first report of HAM development in an HLTV-I-infected LDLT recipient.
Soyama
Akihiko
A
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Eguchi
Susumu
S
Takatsuki
Mitsuhisa
M
Ichikawa
Tatsuki
T
Moriuchi
Masako
M
Moriuchi
Hiroyuki
H
Nakamura
Tatsufumi
T
Tajima
Yoshitsugu
Y
Kanematsu
Takashi
T
D000998:Antiviral Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006084:Graft Rejection / Q000517:prevention & control; D006526:Hepatitis C / Q000150:complications* / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D011994:Recombinant Proteins; D013256:Steroids / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome; D014555:Urination Disorders / Q000209:etiology
D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013256:Steroids; D016559:Tacrolimus