title: [Correlation between the effect of chemotherapy on complement conformation and on CA-125 antigen in the blood plasma of patients with ovarian carcinoma].
abstract: Correlation was investigated between blood-plasma levels of C3(H2)O (conformation pattern of C3 component of the complement) and tumor-associated marker CA-125 in patients with ovarian cancer before and after chemotherapy. Since a drop in CA-125 level after chemotherapy was associated with similar changes in C3(H2)O fraction, it seems reasonable to suggest that change in conformation of C3 is a response of the immune system to cancer.
authors.forename: O A
authors.initials: OA
authors.lastname: Kniazeva
authors.forename: D D
authors.initials: DD
authors.lastname: Sakaeva
authors.forename: F Kh
authors.initials: FKh
authors.lastname: Kamilov
authors.forename: V A
authors.initials: VA
authors.lastname: Vakhitov
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D018394:CA-125 Antigen / Q000097:blood* / Q000187:drug effects*; D003176:Complement C3 / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D011487:Protein Conformation / Q000187:drug effects
chemical_list: D018394:CA-125 Antigen; D003176:Complement C3