title: Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States.
abstract: The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 bla(KPC)-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids.
authors.affiliation: Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Endimiani
authors.forename: Lenore L
authors.initials: LL
authors.lastname: Carias
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Hujer
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Bethel
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Hujer
authors.forename: Federico
authors.initials: F
authors.lastname: Perez
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Hutton
authors.forename: William R
authors.initials: WR
authors.lastname: Fox
authors.forename: Geraldine S
authors.initials: GS
authors.lastname: Hall
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: David L
authors.initials: DL
authors.lastname: Paterson
authors.forename: Louis B
authors.initials: LB
authors.lastname: Rice
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Jenkins
authors.forename: Fred C
authors.initials: FC
authors.lastname: Tenover
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
mesh_terms: D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D010957:Plasmids / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology; D014481:United States / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D017931:DNA Primers; D004269:DNA, Bacterial; D015363:Quinolones; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae