Nonalcoholic fatty liver disease as a component of the metabolic syndrome.
Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The association between NAFLD and the metabolic syndrome is well established: the presence of the metabolic syndrome signifies advanced histology in NAFLD patients. Emerging data indicate that patients with NAFLD have a significantly higher prevalence of cardiovascular disease. This article reviews the definitions of the two syndromes, their association, and the cardiovascular risk conferred by both when they occur separately and together. This review also discusses management options for the syndromes, including treating the individual components of the metabolic syndrome in NAFLD patients.
Khashab
Mouen A
MA
Indiana University School of Medicine, RG 4100, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA.
Liangpunsakul
Suthat
S
Chalasani
Naga
N
D002318:Cardiovascular Diseases / Q000150:complications; D005234:Fatty Liver / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D009765:Obesity / Q000150:complications / Q000628:therapy