Commentary: "re-programming or selecting adult stem cells?".
The recent observations that embryonic stemness-associated genes could assist in the "de-differentiation" of adult skin fibroblast cells to "embryonic-like stem cells", using the "somatic cell nuclear transfer" techniques, have been interpreted as indicating a "re-programming" of genes. These reports have demonstrated a "proof of principle" approach to by-pass many, but not all, of the ethical, scientific and medical limitations of the "therapeutic cloning" of embryonic stem cells from embryos. However, while the interpretation that real "re-programming" of all those somatic fibroblastic differentiation genes might be correct, there does exists an alternative hypothesis of these exciting results. Based on the fact that multipotent adult stem cells exist in most, if not all, adult organs, the possibility exists that all these recent "re-programming" results, using the somatic nuclear transfer techniques, actually were the results of transferred rare nuclear material from the adult stem cells residing in the skin of the mouse, monkey and human samples. An examination of the rationale for this challenging hypothesis has been drawn from the hypothesis of the "stem cell theory of cancer", as well as from the field of human adult stem cells research.
Trosko
James E
JE
Center for Integrative Toxicology, Department of Pediatrics/Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA. james.trosko@ht.msu.edu
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology; D000818:Animals; D054338:Cell Transdifferentiation; D065150:Cellular Reprogramming; D019976:Cloning, Organism / Q000941:ethics / Q000379:methods; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000209:etiology / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology; D053652:Nuclear Transfer Techniques; D035845:Research Embryo Creation / Q000941:ethics