title: Plasma gamma-glutamyl transferase activity predicts homocysteine concentration in a large cohort of unselected outpatients.
abstract: OBJECTIVE
  To evaluate the association between gamma-glutamyl transferase (GGT) and homocysteine in plasma.
  
  
  METHODS
  Combined results of GGT, total homocysteine, vitamin B12, folate and creatinine levels were analyzed in outpatients referred for laboratory testing over the past 5 years.
  
  
  RESULTS
  Cumulative results for homocysteine, GGT, B12, creatinine, folate could be retrieved for 449 outpatients > 35 years old over the study period. The concentration of homocysteine significantly increased among tertiles of GGT activity. In multivariable linear regression analysis, GGT activity was independently associated with homocysteine concentration, independent of age, gender, folate, vitamin B12 and serum creatinine levels.
  
  
  CONCLUSIONS
  Plasma GGT activity might be a useful means to predict homocysteine concentration in the general population.
authors.affiliation: Division of Clinical Chemistry, University of Verona Medical School, Verona, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Salvagno
authors.forename: Giovanni
authors.initials: G
authors.lastname: Targher
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Guidi
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D006710:Homocysteine; D005723:gamma-Glutamyltransferase