title: Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review.
abstract: OBJECTIVE
  To review systematically the reported effects of platelet-rich plasma (PRP) on bone regeneration.
  
  
  METHODS
  Up to June 2006, MEDLINE and Cochrane databases were explored with different combinations of three search terms: 'PRP', 'bone regeneration', 'dentistry' and their synonyms.
  
  
  METHODS
  human controlled clinical trials designed to treat maxillofacial bony defects with application of PRP (test) or without PRP (control), including at least five patients with a follow-up period of more than 3 months and using clinical assessment, radiography, histology and/or histomorphometry for evaluation. Literature search, selection of eligible articles and data extraction were carried out independently by two readers.
  
  
  RESULTS
  The literature search revealed 108 references, of which 17 were selected for further analysis. Finally, nine articles fulfilling the inclusion criteria were selected for systematically review. Owing the substantial heterogeneity of the studies it was not possible to analyze the data statistically. An attempt was made to compare results from studies that used similar outcome measures by calculating and adding confidence intervals to the data presented in the original papers. Differences in treatment effects for periodontal defects in terms of clinical attachment level (CAL) were significant (ranging from 0.8 to 3.2 mm). The reported effects of PRP in sinus elevation (compared with their controls) were <10%.
  
  
  CONCLUSIONS
  We found evidence for beneficial effects of PRP in the treatment of periodontal defects. Evidence for beneficial effects of PRP in sinus elevation appeared to be weak. No conclusions can be drawn about other applications of PRP in dentistry.
authors.affiliation: Department of Periodontology & Biomaterials, College of Dental Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Adelina S
authors.initials: AS
authors.lastname: Plachokova
authors.forename: Dimitris
authors.initials: D
authors.lastname: Nikolidakis
authors.forename: Jan
authors.initials: J
authors.lastname: Mulder
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
authors.forename: Nico H J
authors.initials: NH
authors.lastname: Creugers
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D003813:Dentistry; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D019647:Oral Surgical Procedures / Q000379:methods; D010510:Periodontal Diseases / Q000601:surgery*; D053657:Platelet-Rich Plasma / Q000502:physiology*; D019651:Plastic Surgery Procedures / Q000379:methods; D016896:Treatment Outcome