title: High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea.
abstract: This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible role for HBV in the development of non-Hodgkin's lymphoma.
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, South Korea.
authors.forename: Su Cheol
authors.initials: SC
authors.lastname: Park
authors.forename: Sook-Hyang
authors.initials: SH
authors.lastname: Jeong
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.forename: Chul Ju
authors.initials: CJ
authors.lastname: Han
authors.forename: You Cheoul
authors.initials: YC
authors.lastname: Kim
authors.forename: Kui Sung
authors.initials: KS
authors.lastname: Choi
authors.forename: Jang Hyun
authors.initials: JH
authors.lastname: Cho
authors.forename: Myoungjin
authors.initials: M
authors.lastname: Lee
authors.forename: Ha Hyun
authors.initials: HH
authors.lastname: Jung
authors.forename: Seung Seog
authors.initials: SS
authors.lastname: Ki
authors.forename: Yoon Hwan
authors.initials: YH
authors.lastname: Chang
authors.forename: Seung Sook
authors.initials: SS
authors.lastname: Lee
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Kee Ho
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005814:Genes, Viral / Q000235:genetics; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology; D006801:Humans; D007150:Immunohistochemistry; D007723:Korea / Q000453:epidemiology; D007963:Leukocytes, Mononuclear / Q000821:virology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013274:Stomach Neoplasms / Q000150:complications / Q000453:epidemiology
chemical_list: D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens