title: Fournier's gangrene and scrotal ulcerations during all-trans-retinoic acid therapy for acute promyelocytic leukemia.
abstract: Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen in Asian population. A good outcome with supportive management occurred in all the cases.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi, India. dr_rahul6@hotmail.com
authors.forename: Rahul
authors.initials: R
authors.lastname: Naithani
authors.forename: Rajat
authors.initials: R
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Mahapatra
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018934:Fournier Gangrene / Q000139:chemically induced*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D012611:Scrotum / Q000473:pathology*; D014212:Tretinoin / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin