Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis.
In search of reducing vaccine production costs', a recombinant M13 phage version of the anti-cysticercosis tripeptide vaccine (S3Pvac) was developed. The efficacy of S3Pvac-Phage vs. placebo was evaluated in a randomized trial that included 1,047 rural pigs in 16 villages of Central Mexico. Three to five months after vaccination 530 pigs were examined by tongue inspection. At 5-27 months of age, 331 pigs (197 vaccinated/134 controls) were inspected at necropsy. Vaccination reduced 70% the frequency of tongue cysticercosis and, based on necropsy, 54% of muscle-cysticercosis and by 87% the number of cysticerci.
Morales
Julio
J
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico.
Martínez
José Juan
JJ
Manoutcharian
Karen
K
Hernández
Marisela
M
Fleury
Agnes
A
Gevorkian
Goar
G
Acero
Gonzalo
G
Blancas
Abel
A
Toledo
Andrea
A
Cervantes
Jacquelynne
J
Maza
Victor
V
Quet
Fabrice
F
Bonnabau
Henri
H
de Aluja
Aline S
AS
Fragoso
Gladis
G
Larralde
Carlos
C
Sciutto
Edda
E
D000375:Aging / Q000276:immunology; D000818:Animals; D000947:Antigens, Helminth / Q000096:biosynthesis / Q000276:immunology*; D017104:Bacteriophage M13 / Q000276:immunology* / Q000378:metabolism; D003551:Cysticercosis / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary*; D008800:Mexico; D012424:Rural Population; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D014612:Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D015164:Vaccines, Inactivated / Q000276:immunology; D015430:Weight Gain / Q000187:drug effects
D000947:Antigens, Helminth; D014612:Vaccines; D015164:Vaccines, Inactivated