title: The use of statins and fate of small abdominal aortic aneurysms.
abstract: The aim of this study was to evaluate the value of statins in reducing abdominal aortic aneurysm (AAA) growth rate and improving freedom from aneurysm repair or rupture. One hundred and twenty-one patients with AAA undergoing ultrasonographic surveillance for at least one year were included in this retrospective study. Patients treated with statins had a decreased linear aneurysm growth rate than those not receiving statins (1.9+/-1.8 mm/year vs. 2.6+/-2.4 mm/year, P=0.27), but this difference did not reach statistical significance. Statin users had a better survival freedom from aneurysm repair or rupture (at 5 years: 72.3% vs. 52.5%, P=0.048). The impact of treatment with statins was even more evident in patients with a baseline aneurysm diameter<40 mm (at 5 years: 84.0% vs. 58.8%, P=0.022). When adjusted for age, coronary artery disease and baseline aneurysm diameter, treatment with statins had significantly better survival freedom from aneurysm repair or rupture (P=0.012, RR 0.34, 95% CI 0.14-0.78). The use of statins seems to slightly decrease the AAA growth rate and to significantly improve freedom from aneurysm repair and rupture.
authors.affiliation: Division of Cardio-thoracic and Vascular Surgery, Department of Surgery, Oulu University Hospital, PO Box 21, 90029 Oulu, Finland.
authors.forename: Martti
authors.initials: M
authors.lastname: Mosorin
authors.forename: Eija
authors.initials: E
authors.lastname: Niemelä
authors.forename: Jouni
authors.initials: J
authors.lastname: Heikkinen
authors.forename: Jarmo
authors.initials: J
authors.lastname: Lahtinen
authors.forename: Valentina
authors.initials: V
authors.lastname: Tiozzo
authors.forename: Jari
authors.initials: J
authors.lastname: Satta
authors.forename: Tatu
authors.initials: T
authors.lastname: Juvonen
authors.forename: Fausto
authors.initials: F
authors.lastname: Biancari
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D001019:Aortic Rupture / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D014656:Vascular Surgical Procedures
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors