[Progress in labeled immunoassay based on SERS].
Labeled immunoassay utilizing surface-enhanced Raman spectroscopy (SERS) is a new-style research technology. The discovery and confirmation of surface-enhanced Raman spectroscopy have made Raman spectroscopy a powerful tool in many research fields. SERS has the advantages such as high sensibility and selectivity, also it is suitable for the study of liquid substance. In recent years, it has shown potential application future in biomedical field, and also developed fast in labeled immunoassay. The principle, specialty, problem and recent advances of labeled immunoassay based on SERS were reviewed in terms of detection limits, non-specific adsorption and multi-analyte immunoassay. The latest advancement in the improvement of detection limits was summarized, along with the introduction of some work in our lab, as well as expatiating on the effect of non-specific adsorption. Finally, the development trends and application perspectives were discussed.
Ge
Ming
M
Department of Chemistry, Suzhou University, Suzhou 215123, China.
Cui
Yan
Y
Gu
Ren-Ao
RA
D000327:Adsorption; D000818:Animals; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D057230:Limit of Detection; D013059:Spectrum Analysis, Raman; D013194:Staining and Labeling; D013499:Surface Properties