Is brain banking of psychiatric cases valuable for neurobiological research?
It is widely accepted that neurobiological abnormalities underlie the symptoms of psychiatric disorders such as schizophrenia and unipolar or bipolar affective disorders. New molecular methods, computer-assisted quantification techniques and neurobiological investigation methods that can be applied to the human brain are all used in post-mortem investigations of psychiatric disorders. The following article describes modern quantitative methods and recent post-mortem findings in schizophrenia and affective disorders. Using our brain bank as an example, necessary considerations of modern brain banking are addressed such as ethical considerations, clinical work-up, preparation techniques and the organization of a brain bank, the value of modern brain banking for investigations of psychiatric disorders is summarized.
Schmitt
Andrea
A
Department of Psychiatry, University of Goettingen, Germany. aschmit@gwdg.de
Parlapani
Eleni
E
Bauer
Manfred
M
Heinsen
Helmut
H
Falkai
Peter
P
D001344:Autopsy / Q000379:methods; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D009446:Neurobiology; D011570:Psychiatry; D012559:Schizophrenia / Q000473:pathology*; D014015:Tissue Banks