Application of natural product-inspired diversity-oriented synthesis to drug discovery.
Natural products have played a critical role in the identification of numerous medicines. Synthetic organic chemistry and combinatorial chemistry strategies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strategies to access novel compounds inspired by natural products will be reviewed.
Marcaurelle
Lisa A
LA
Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02412, USA. lisa@broad.mit.edu
Johannes
Charles W
CW
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000379:methods
D001688:Biological Products; D054852:Small Molecule Libraries