[Efficacy and tolerability of clomipramine, pirlindole and escitalopram in the treatment of neurotic level depression].
The open comparative study of three antidepressants with different mechanisms of action - clomipramine, pirlindole and escitalopram - in the treatment of neurotic level depression (ICD-10 items F32-F34, F43) has been carried out. Ninety-one patients have been stratified into three groups included 31, 31 and 29 patients, respectively.. Duration of the study has been 12 weeks. Clomipramine, pirlindole and escitalopram have similar effect decreasing the total HAMD score by more than 50% (in average 72%). Clomipramine appears to be more effective in the achievement of remission (63%) as compared to pirlindole (40%) and escitalopram (42%). The tolerability of pirlindole and escitalopram is higher than that of clomipramine and the authors recommend prescription of these drugs to patients with neurotic depression.
Bun'kova
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D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D015283:Citalopram / Q000008:administration & dosage / Q000627:therapeutic use*; D002997:Clomipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D002227:Carbazoles; D015283:Citalopram; D002997:Clomipramine; D017367:Selective Serotonin Reuptake Inhibitors; C009830:pirlindole