title: Congenital hyposomatotropism in a domestic shorthair cat presenting with congenital corneal oedema.
abstract: A six-month-old, female, domestic shorthair cat was presented with a history of failure to grow and bilateral corneal opacity caused by corneal oedema. Congenital hyposomatotropism and possible secondary hypothyroidism were diagnosed on the basis of fasting serum levels of insulin-like growth factor-1 and thyroxine levels, respectively. These endocrinopathies are rare in the cat and have not been reported to cause ocular signs. The cat died during investigation of these diseases, and histopathological examination of the eyes showed significantly reduced corneal endothelial cell density and number of corneal epithelial cell layers when compared with age-matched healthy control corneas. These changes were implicated in the development of the corneal oedema.
authors.affiliation: Comparative Ophthalmology Unit, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU.
authors.forename: D
authors.initials: D
authors.lastname: Donaldson
authors.forename: F M
authors.initials: FM
authors.lastname: Billson
authors.forename: T J
authors.initials: TJ
authors.lastname: Scase
authors.forename: A H
authors.initials: AH
authors.lastname: Sparkes
authors.forename: F
authors.initials: F
authors.lastname: McConnell
authors.forename: J R B
authors.initials: JR
authors.lastname: Mould
authors.forename: V
authors.initials: V
authors.lastname: Adams
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000151:congenital* / Q000175:diagnosis; D002415:Cats; D015715:Corneal Edema / Q000151:congenital / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004393:Dwarfism, Pituitary / Q000150:complications / Q000151:congenital / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D013974:Thyroxine / Q000097:blood
chemical_list: D007334:Insulin-Like Growth Factor I; D013974:Thyroxine