[(Possible) molecular mechanism of cells in gravisensing].
Although it is clear that changes of gravity can alter dramatically the functions and structures of cells, little is known about how living cells sense these signals and convert them into a biochemical response. Recent studies estimated that the changes of gravity might influence the single cell directly and indirectly. So far, the molecular mechanism of gravisensing remains unknown, however, according to a great deal of researches focusing on this point, several pathways could be considered: (1) Pre-stress perception pathway; (2) Cytoskeleton-perception pathway; (3) Stress-sensitive ion channel pathway; (4) Indirect effects of gravitational change.
Wang
Chi
C
Department of Bioengineering, Beihang University, Beijing 100083, China. chiwangcw@yahoo.com.cn
Zhuang
Fengyuan
F
D002468:Cell Physiological Phenomena; D003599:Cytoskeleton / Q000502:physiology; D006112:Gravitation; D018466:Gravity Sensing / Q000502:physiology*; D015398:Signal Transduction; D013026:Space Flight; D014893:Weightlessness