Microwave-assisted synthesis of phenylene-bridged aminophosphine ligands: acceleration of N-arylation and aryl fluoride phosphorylation reactions.
Hindered beta-aminoarylphosphines show promise as bidentate ligands for metal centers, but their reported synthesis requires heating at high temperatures for several days. Herein are reported conditions by which the two steps composing this synthesis, Buchwald-Hartwig amination and nucleophilic phosphorylation reactions, may both be completed in less than 3 h using microwave irradiation. The effects of several parameters on the outcome of the amination reaction are discussed, as are some indications of the scope within which each of these microwave protocols is effective.
Seipel
Kelsey R
KR
Department of Chemistry, Idaho State University, 921 South Eighth Avenue, Pocatello, ID 83209, USA.
Platt
Zed H
ZH
Nguyen
Minh
M
Holland
Andrew W
AW
D008024:Ligands; D008872:Microwaves; D010636:Phenols / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D010766:Phosphorylation
D008024:Ligands; D010636:Phenols; D010720:Phosphines; C044646:phosphine