[Ki-67 and p53 expression as prognosticators of clinical course aggressiveness of squamous cell cancer of the larynx].
The study used bioptic sampling material from 64 patients with invasive squamous cell cancer of the larynx, aged 34-77 (mean age--56 +/- 1.2), receiving combined treatment at the Center's Clinic, Obninsk. Ki-67 and p53 levels were assayed vs. such clinico-anatomical parameters as tumor size, cell differentiation grade and presence of regional metastasis. The study revealed a significant direct correlation between Ki-67 index, on the one hand, and tumor size, tumor cell differentiation and relapse, on the other. p53 expression in tumor tissue was associated with a relatively high incidence of relapse (p = 0.01). Both markers may be used as prognosticators of survival in laryngeal cancer.
Gorban'
N A
NA
Ten
V P
VP
Pankratov
V A
VA
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D002454:Cell Differentiation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry; D011237:Predictive Value of Tests; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53