Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia).
OBJECTIVE
We aimed to establish the animal model of Vogt-Koyanagi-Harada disease (VKH).


METHODS
Rats, Akita dogs and monkeys were immunized with the peptides derived from tyrosinase-related protein 1. Each experimental animal was examined clinically and histologically.


CONCLUSIONS
The rats developed ocular and extraocular inflammation homologous to human VKH by immunization of tyrosinase-related protein 1. The Akita dogs also developed the autoimmune disease almost similar to the spontaneously emerging dog VKH equivalent to human VKH. The monkeys developed similar clinical findings as human VKH. These models may serve as human VKH models.
Yamaki
Kunihiko
K
Department of Ophthalmology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. kyamaki@nms.ac.jp
Ohono
Shigeaki
S
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D007114:Immunization; D008253:Macaca mulatta; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology*; D033401:Microscopy, Acoustic; D008856:Microscopy, Fluorescence; D010088:Oxidoreductases / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000000981:diagnostic imaging / Q000473:pathology*; D014607:Uveomeningoencephalitic Syndrome / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology
D008562:Membrane Glycoproteins; D010446:Peptide Fragments; D010088:Oxidoreductases; C489799:TYRP1 protein, human