Plasma exchange in a case of severe factor X deficiency in pregnancy: critical review of the literature.
Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.
Chiossi
Giuseppe
G
Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
Spero
Joel A
JA
Esaka
Emmanuel J
EJ
Novic
Kristin
K
Celebrezze
Jennifer U
JU
Golde
Steven H
SH
Thomas
Ronald L
RL
D001946:Breech Presentation / Q000601:surgery; D002585:Cesarean Section; D005171:Factor X Deficiency / Q000628:therapy*; D005260:Female; D006801:Humans; D010951:Plasma Exchange; D006473:Postpartum Hemorrhage / Q000517:prevention & control; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*