title: Synthesis of fluorinated nucleosides.
abstract: Two practical synthetic approaches to the production of lodenosine [FddA, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine] via 6-chloropurine riboside or 6-chloropurine 3'-deoxyriboside are described. The reaction sequence contains new fluorination methods and new applications of radical reduction. The reagents and reaction conditions of each step have been carefully selected to ensure robustness and safety.
authors.affiliation: AminoScience Laboratories, Ajinomoto Co., Kanagawa, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Katayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Naoko
authors.initials: N
authors.lastname: Hirose
authors.forename: Kunisuke
authors.initials: K
authors.lastname: Izawa
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005461:Fluorine / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007202:Indicators and Reagents; D009705:Nucleosides; D005461:Fluorine