The antiulcer effect of Croton cajucara Benth in normoproteic and malnourished rats.
The aim of the present study is to investigate the antiulcerogenic effects of the essential oil (EO) of Croton cajucara Benth in rats fed with a normal protein (NP) and low-protein diet (MN). NP and MN rats were treated with the essential oil for 15 days after chronic ulceration was induced. The EO accelerated healing of acetic acid-induced gastric lesions in NP and MN rats (p<0.05). In a similar experiment on chronic ulceration, Epidermal Growth Factor (EGF) mRNA expression increased in NP rats but not in MN rats. In assays of acute antiulcerogenic activity, C. cajucara increased somatostatin plasma levels and decreased gastrin plasma levels in both animal groups. The EO significantly prevented ethanol-induced gastric ulcers in NP and MN rats (p<0.001). Histological examination showed initial regeneration, formation of inflammatory infiltrate and angiogenesis in the epithelium surface of acetic acid-induced ulcers in NP and MN rats. C. cajucara prevented gastric lesions in both animal groups when ethanol methodology was used. We concluded that the EO showed an antiulcerogenic activity mediated by increased somatostatin secretion and EGF mRNA expression.
De Paula
Ana Claudia B
AC
Department of Physiology and Biophysics, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. anabensuaski@yahoo.com.br
Gracioso
Juliano S
JS
Toma
Walber
W
Hiruma-Lima
Clélia A
CA
Carneiro
Everardo M
EM
Brito
Alba R M Souza
AR
D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001483:Base Sequence; D029802:Croton / Q000737:chemistry*; D017931:DNA Primers; D004044:Dietary Proteins / Q000008:administration & dosage; D004815:Epidermal Growth Factor / Q000235:genetics; D005260:Female; D005755:Gastrins / Q000097:blood; D044342:Malnutrition / Q000150:complications*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000150:complications / Q000517:prevention & control; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013004:Somatostatin / Q000097:blood
D000897:Anti-Ulcer Agents; D017931:DNA Primers; D004044:Dietary Proteins; D005755:Gastrins; D012333:RNA, Messenger; D013004:Somatostatin; D004815:Epidermal Growth Factor; D019342:Acetic Acid