title: Randomized clinical trial on the effects of full mouth disinfection versus conventional quadrant therapy in the control of chronic periodontitis.
abstract: OBJECTIVE
  This clinical trial investigates the effectiveness of full-mouth disinfection (FMD) versus conventional etiological therapy in patients with chronic periodontitis (CP).
  
  
  METHODS
  The therapy effectiveness was assessed by a randomized trial, performed over 20 adult periodontitis (AP) patients, divided into two groups. Patients were recruited undergoing strict inclusion/exclusion criteria. The following parameters were considered to evaluate and compare the two procedures: bleeding on probing (BOP), Plaque Index (PLI), probing depth (PD), clinical attachment level (CAL). These clinical data were collected at baseline and at three follow-ups (three months, six months and twelve months from baseline). Each parameter was averaged within each group; then statistic comparisons were performed within groups and between groups.
  
  
  RESULTS
  In the test-group statistically significant improvements (P<0.001) were found for all parameters between baseline and every following review. The same result was reported in the control group (with a further significant difference between first and second review). Finally, the comparison between groups did not show any difference at any time for every parameter considered.
  
  
  CONCLUSIONS
  FMD outcomes are similar to those of the conventional therapy and improvements can be achieved more quickly. FMD does not cause remarkable side effects and reduces the number of therapy sessions. Some aspects about this treatment need further research: maybe FMD could give an extra reduction of bacterial load, in comparison with traditional therapy, resulting in a longer free-infection period; that could allow a decrease in the frequency of supporting periodontal treatment.
authors.affiliation: Division of Odontostomatology, Department of Sciences and Biophysical Medical and Odontostomatological Techniques, University of Genoa, Genoa, Italy. matlat@uno.it
authors.forename: M
authors.initials: M
authors.lastname: Latronico
authors.forename: R
authors.initials: R
authors.lastname: Russo
authors.forename: F
authors.initials: F
authors.lastname: Garbarino
authors.forename: C
authors.initials: C
authors.lastname: Rolandi
authors.forename: A
authors.initials: A
authors.lastname: Mascolo
authors.forename: G
authors.initials: G
authors.lastname: Blasi
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004203:Disinfection; D006801:Humans; D010518:Periodontitis / Q000517:prevention & control*