title: [Evaluation of liver function before living donor liver transplantation and liver resection].
abstract: Liver resection is the curative therapeutic option for hepatocellular carcinoma, biliary tumors, metastases of colorectal and other extrahepatic tumors, living donor liver transplantation and other benign liver diseases.
  
  
  OBJECTIVE
  To summarize the evaluation methods of liver function before living donor liver transplantation and liver resection.
  
  
  METHODS
  We summarize the literature about the evaluation of liver function.
  
  
  RESULTS
  Perioperative mortality is determined mostly by the extent of preoperative evaluation focused on the liver. After resection the remnant liver parenchyma must cope with the challenge caused by increased metabolism, portal overflow, decreased vascular bed and biliary tract and oxidative stress following the operation. If the remnant liver is unable to grow up to this challenge, acute liver failure occurs. This maintains the necessity of determining the hepatic functional reserve and the hepatic remnant volume. Child-Pugh classification is widely spread to predict outcome. Dynamic functional tests such as indocyanine green retention test, galactosyl human serum albumin scintigraphy and aminopyrine breath tests can be used to evaluate hepatic reserve. To determine remnant liver volume modern imaging processes such as CT volumetry and hepatobiliary scintigraphy are available.
  
  
  CONCLUSIONS
  After the detailed evaluation resection can be limited to an extent which is oncologically radical enough (1% remnant liver tissue/kg) and spares parenchyma which can ensure survival yet. With careful preoperative examination mortality can be reduced even to reach zero.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar Transzplantációs és Sebészeti Klinika Budapest Baross u. 23. 1082.
authors.forename: Tamás
authors.initials: T
authors.lastname: Mándli
authors.forename: János
authors.initials: J
authors.lastname: Fazakas
authors.forename: Gábor
authors.initials: G
authors.lastname: Ther
authors.forename: Mónika
authors.initials: M
authors.lastname: Arkosy
authors.forename: Balázs
authors.initials: B
authors.lastname: Füle
authors.forename: Endre
authors.initials: E
authors.lastname: Németh
authors.forename: Judit
authors.initials: J
authors.lastname: Fazakas
authors.forename: Márta
authors.initials: M
authors.lastname: Hidvégi
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Tóth
mesh_terms: D000632:Aminopyrine / Q000378:metabolism; D001659:Biliary Tract / Q000000981:diagnostic imaging; D001944:Breath Tests / Q000379:methods; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D018281:Cholangiocarcinoma / Q000601:surgery; D005690:Galactose / Q000378:metabolism; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D007208:Indocyanine Green; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D008102:Liver Circulation; D017114:Liver Failure, Acute / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation; D019520:Living Donors; D018384:Oxidative Stress; D011168:Portal System; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D012709:Serum Albumin; D000632:Aminopyrine; D007208:Indocyanine Green; D005690:Galactose