title: Neurocognition in first-degree healthy relatives (siblings) of bipolar affective disorder patients.
abstract: OBJECTIVE
  Cognitive deficits have been presupposed to be endophenotypic markers in bipolar disorder, but few studies have ascertained the cognitive deficits in healthy relatives of bipolar disorder patients. The aim of the present study was to assess the cognitive functions of first-degree relatives of patients with bipolar disorder and compare them with healthy controls.
  
  
  METHODS
  Ten first-degree apparently healthy relatives of patients with bipolar disorder were compared with 10 age- and education-matched control subjects on computer-based cognitive tests.
  
  
  RESULTS
  As compared to the control group, the relatives group performed significantly poorly on tests for executive function and vigilance, while on the test for working memory the performance was not significantly different on most of the parameters.
  
  
  CONCLUSIONS
  Executive functioning and vigilance could be potential markers of the endophenotype in bipolar patients.
authors.affiliation: Department of Psychiatry, King George's Medical University, Lucknow, India. jktrivedi@hotmail.com
authors.forename: Jitendra K
authors.initials: JK
authors.lastname: Trivedi
authors.forename: Dishanter
authors.initials: D
authors.lastname: Goel
authors.forename: Mohan
authors.initials: M
authors.lastname: Dhyani
authors.forename: Sachin
authors.initials: S
authors.lastname: Sharma
authors.forename: Anand P
authors.initials: AP
authors.lastname: Singh
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Sinha
authors.forename: Rajul
authors.initials: R
authors.lastname: Tandon
mesh_terms: D000328:Adult; D001288:Attention; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D004193:Discrimination Learning; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D009949:Orientation; D010364:Pattern Recognition, Visual; D010641:Phenotype; D011340:Problem Solving; D011594:Psychometrics; D011597:Psychomotor Performance; D012016:Reference Values; D035781:Siblings