Conjugation of ATIII-binding pentasaccharides to extend the half-life of proteins: long-acting insulin.
de Kort
Martin
M
Department of Medicinal Chemistry, N.V. Organon, part of Schering-Plough Corporation, Molenstraat 110, PO Box 20, 5340 BH, Oss, The Netherlands. m.dekort@organon.com
Gianotten
Bas
B
Wisse
Jeffry A J
JA
Bos
Ebo S
ES
Eppink
Michel H M
MH
Mattaar
Ellen
E
Vogel
Gerard M T
GM
Dokter
Wim H A
WH
Honing
Maarten
M
Vonsovic
Stanislava
S
Smit
Martin-Jan
MJ
Wijkmans
Jac C H M
JC
van Boeckel
Constant A A
CA
D000595:Amino Acid Sequence; D000818:Animals; D000990:Antithrombin III / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006207:Half-Life; D049528:Insulin, Long-Acting / Q000097:blood / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D051381:Rats; D017208:Rats, Wistar
D049528:Insulin, Long-Acting; D009844:Oligosaccharides; D000990:Antithrombin III