title: Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome.
abstract: We report the case of a girl with hemimegalencephaly (HME) and Lennox-Gastaut syndrome (LGS) treated by callosotomy at 1 year of age. Over 10 years, her seizure frequency and severity decreased markedly. Hemispherectomy is the main surgical option for HME although HME appears to correlate with a less favorable seizure outcome. However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable surgical outcome of corpus callosotomy in patients of HME, as in our case.
authors.affiliation: Pediatric Epilepsy Surgery Group, Taipei Veterans General Hospital & School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Shang-Yeong
authors.initials: SY
authors.lastname: Kwan
authors.forename: Hann-Yeh
authors.initials: HY
authors.lastname: Shyu
authors.forename: Ji-Ho
authors.initials: JH
authors.lastname: Lin
authors.forename: Tai-Tong
authors.initials: TT
authors.lastname: Wong
authors.forename: Kai-Ping
authors.initials: KP
authors.lastname: Chang
authors.forename: Chun-Hing
authors.initials: CH
authors.lastname: Yiu
mesh_terms: D000293:Adolescent; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D054220:Malformations of Cortical Development / Q000503:physiopathology / Q000601:surgery*; D013577:Syndrome