Cytomegalovirus infection via mother's milk: could distinct virus strains determine different disease patterns in preterm twins?
We describe a case of cytomegalovirus infection via the mother's milk in preterm twins who showed a different disease pattern. Molecular analyses to genotype the viral genome disclosed a mixed population of virus strains in the milk. These isolates were differentially transmitted to each of the twins and this may be responsible of the different patterns of disease.
Lanari
Marcello
M
Department of Gynecological, Ostetrical and Pediatric Sciences, Clinical Unit of Neonatology, St. Orsola Malpighi General Hospital, University of Bologna, Bologna, Italy.
Capretti
Maria Grazia
MG
Lazzarotto
Tiziana
T
Gabrielli
Liliana
L
Pignatelli
Sara
S
Dal Monte
Paola
P
Landini
Maria Paola
MP
Faldella
Giacomo
G
D000328:Adult; D001942:Breast Feeding / Q000009:adverse effects; D003587:Cytomegalovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000503:physiopathology / Q000635:transmission / Q000821:virology; D004200:Diseases in Twins / Q000503:physiopathology / Q000821:virology; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000821:virology; D019102:Infant, Very Low Birth Weight; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008895:Milk, Human / Q000821:virology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D014427:Twins