(1)H MR spectroscopy in pediatrics.
Spectral appearance and concentrations of the most prominent metabolites are affected by brain development. This knowledge is essential for the detection of pathological changes in pediatric patients. This paper discusses specific conditions of MR spectroscopic examination of children and the effects of age on MR spectra quality and quantitation of the studied metabolites. Clinical examples show several diseases that are reflected in changes in (1)H MR spectra due to pathological alterations in the biochemical pathways of the observed metabolites. Attention is given to the main metabolites such as N-acetylaspartate, creatine/phosphocreatine, cholines, lactate, inositol, etc.
Dezortova
Monika
M
MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic. Electronic address: mode@medicon.cz.
Hajek
Milan
M
MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic. Electronic address: miha@medicon.cz.
D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001923:Brain Chemistry; D001927:Brain Diseases / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010725:Phosphocreatine / Q000378:metabolism
D010725:Phosphocreatine; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; D003401:Creatine; D002794:Choline