title: Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.
abstract: OBJECTIVE
  To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication.
  
  
  METHODS
  Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy.
  
  
  METHODS
  Change in 11C-PiB uptake.
  
  
  RESULTS
  Uptake of 11C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased 11C-PiB uptake was different from that seen in sporadic Alzheimer disease.
  
  
  CONCLUSIONS
  Amyloid imaging with 11C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of 11C-PiB accumulation differs between patients with typical AD and patients with APP locus duplication.
authors.affiliation: Clinical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland. anne.remes@oulu.fi
authors.forename: Anne M
authors.initials: AM
authors.lastname: Remes
authors.forename: Lauri
authors.initials: L
authors.lastname: Laru
authors.forename: Hannu
authors.initials: H
authors.lastname: Tuominen
authors.forename: Sargo
authors.initials: S
authors.lastname: Aalto
authors.forename: Nina
authors.initials: N
authors.lastname: Kemppainen
authors.forename: Helinä
authors.initials: H
authors.lastname: Mononen
authors.forename: Kjell
authors.initials: K
authors.lastname: Någren
authors.forename: Riitta
authors.initials: R
authors.lastname: Parkkola
authors.forename: Juha O
authors.initials: JO
authors.lastname: Rinne
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D002421:Caudate Nucleus / Q000000981:diagnostic imaging; D028243:Cerebral Amyloid Angiopathy, Familial / Q000000981:diagnostic imaging* / Q000235:genetics; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D020440:Gene Duplication; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D058255:Protease Nexins; D011699:Putamen / Q000000981:diagnostic imaging; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D012680:Sensitivity and Specificity; D013702:Temporal Lobe / Q000000981:diagnostic imaging; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D013844:Thiazoles