Molecular tools for the rapid detection of drug resistance in animal trypanosomes.
There are currently 17 African countries in which animal trypanocidal drug resistance has been reported. Large-scale surveys were carried out in only ten of them. The lack of baseline information is mainly due to the fact that the methods currently available for the detection of drug resistance are laborious, expensive and time consuming. In this review the mechanisms involved in resistance to isometamidium and diminazene will be discussed, together with some new molecular detection tools that have been developed recently enabling faster diagnosis of drug resistance than conventional laboratory or field tests.
Delespaux
Vincent
V
Animal Health Department, Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium. vdelespaux@itg.be
Geysen
Dirk
D
Van den Bossche
Peter
P
Geerts
Stanny
S
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology*; D004133:Diminazene / Q000627:therapeutic use; D004351:Drug Resistance; D010617:Phenanthridines / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*
D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride; D004133:Diminazene