Development of microporous drug-releasing films cast from artificial nanosized latexes of poly(styrene-co-methyl methacrylate) or poly(styrene-co-ethyl methacrylate).
Two sets of copolymers comprising of styrene and either methyl or ethyl methacrylate as comonomer were conveniently synthesized by microemulsion copolymerization. The purified materials were characterized by GPC-MALLS and were shown to form artificial nanolatexes in THF. ATR-FTIR analysis revealed differences in copolymer composition and based on the copolymer properties, a selection of copolymers was chosen to cast drug-loaded, microporous films that exhibit microencapsulation of drug agglomerates. The contact angles of the copolymers suggested potential applications in medical devices to prevent the formation of bacterial biofilms that commonly result in infections. Additionally, the different copolymeric films showed two phases of drug release characterized by a rapid initial drug release followed by a zero-order phase. Depending on the application, one could select the copolymer films that best suited the application i.e. for short-term drug release applications such as urinary catheters or long-term applications such as artificial implants.
Otto
Daniel P
DP
School of Pharmacy, University of Wisconsin - Madison, WI 53705, USA. dotto@wisc.edu
Vosloo
Hermanus C M
HC
Liebenberg
Wilna
W
de Villiers
Melgardt M
MM
D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005079:Excipients; D007840:Latex / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D012293:Rifampin / Q000008:administration & dosage / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D000904:Antibiotics, Antitubercular; D003692:Delayed-Action Preparations; D005079:Excipients; D007840:Latex; D008689:Methacrylates; D011109:Polymethacrylic Acids; D011137:Polystyrenes; C532508:poly(styrene-co-ethyl methacrylate); C522509:polystyrene-block-poly(methyl methacrylate); D012293:Rifampin