Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.
Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.
Mezger
Markus
M
Medizinische Klinik II, Universität Würzburg, 97070 Würzburg, Germany.
Wozniok
Iwona
I
Blockhaus
Christian
C
Kurzai
Oliver
O
Hebart
Holger
H
Einsele
Hermann
H
Loeffler
Juergen
J
D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000472:pathogenicity; D002454:Cell Differentiation / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000378:metabolism; D009173:Mycophenolic Acid / Q000009:adverse effects*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D016897:Respiratory Burst / Q000187:drug effects
D016207:Cytokines; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D009173:Mycophenolic Acid