title: Centromeres in cell division, evolution, nuclear organization and disease.
abstract: As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.
authors.affiliation: Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Amanda
authors.initials: A
authors.lastname: Gonçalves Dos Santos Silva
authors.forename: Rahul
authors.initials: R
authors.lastname: Sarkar
authors.forename: Jana
authors.initials: J
authors.lastname: Harizanova
authors.forename: Amanda
authors.initials: A
authors.lastname: Guffei
authors.forename: Michael
authors.initials: M
authors.lastname: Mowat
authors.forename: Yuval
authors.initials: Y
authors.lastname: Garini
authors.forename: Sabine
authors.initials: S
authors.lastname: Mai
mesh_terms: D005075:Biological Evolution; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism*; D002503:Centromere / Q000378:metabolism*; D004194:Disease; D006801:Humans; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000473:pathology