[New channels and transporters as anti-malaria drug targets].
In order to get more nutrition from outside the erythrocyte, new channels were induced by malaria parasite. These channels play an important role in physiology of the parasitized cell. They are of interest both as potential targets in their own right and as potential drug targeting routes capable of mediating the entry of cytotoxic drugs into the appropriate compartment of the infected cell. It is hoped that this new anti-malarial strategy will help to create a sustainable anti-malaria-drug-development portfolio for the treatment of malaria.
Xu
Tao
T
Department of Parasitology, The Second Military Medical University, Shanghai 200433, China.
Zhu
Huai-min
HM
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000469:parasitology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008288:Malaria / Q000188:drug therapy / Q000378:metabolism / Q000469:parasitology; D026901:Membrane Transport Proteins / Q000378:metabolism*
D000962:Antimalarials; D007473:Ion Channels; D026901:Membrane Transport Proteins