Osmium carbonyl clusters: a new class of apoptosis inducing agents.
Osmium carbonyl clusters, especially the cluster [Os(3)(CO)(10)(NCCH(3))(2)], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number of morphological and apoptosis assays, all of which pointed to the induction of apoptosis.
Kong
Kien Voon
KV
Department of Chemistry, National University of Singapore, Kent Ridge, Singapore 117543, Singapore.
Leong
Weng Kee
WK
Ng
Swee Phyaw
SP
Nguyen
Thanh Hung
TH
Lim
Lina H K
LH
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D017892:Osmium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D017892:Osmium Compounds