Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis.
Rasmussen encephalitis (RE) is a rare form of severe unihemispheric epilepsy established to be an autoimmune disease. Here we demonstrate the presence of autoantibodies against Munc18-1 in 20% of patients collective with biopsy-proven RE. Intriguingly, brain biopsy specimens of these patients showed a striking perivascular accentuated infiltration of B-lymphocytes and plasma cells, suggesting a subgroup of RE patients harboring Munc18-1 antibodies and concomitant B- and plasma cell infiltration.
Alvarez-Barón
Elena
E
Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str. 25, 53105 Bonn, Germany. elenaabf@gmail.com
Bien
Christian G
CG
Schramm
Johannes
J
Elger
Christian E
CE
Becker
Albert J
AJ
Schoch
Susanne
S
D000293:Adolescent; D000328:Adult; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001323:Autoantibodies / Q000378:metabolism*; D001402:B-Lymphocytes / Q000473:pathology*; D002461:Cell Line, Transformed; D002648:Child; D004660:Encephalitis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D051938:Munc18 Proteins / Q000276:immunology*; D010950:Plasma Cells / Q000473:pathology*; D014162:Transfection
D015703:Antigens, CD; D001323:Autoantibodies; D051938:Munc18 Proteins