Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma.
OBJECTIVE
The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities.


METHODS
Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria.


RESULTS
The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003).


CONCLUSIONS
There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas.
Bispo Júnior
Rosalvo Zósimo
RZ
Institute of Orthopedics and Traumatology, HC, Medical School, São Paulo University, São Paulo, SP, Brazil. zosimo_jr@yahoo.com.br
Camargo
Olavo Pires de
OP
Oliveira
Cláudia Regina G C M de
CR
Filippi
Renée Zon
RZ
Baptista
André Mathias
AM
Caiero
Marcelo Tadeu
MT
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001706:Biopsy; D018572:Disease-Free Survival; D005121:Extremities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D012737:Sex Factors; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000401:mortality; D055815:Young Adult
D014408:Biomarkers, Tumor; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2