title: Solubilisation of drugs in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide.
abstract: The solubilisation of two poorly soluble drugs, furosemide and nabumetone, in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide has been studied at 25 and 37 degrees C and solubilisation capacities compared with published values for griseofulvin and docetaxel. Solubilisation in the micelle core, corrected for the different proportions of poly(styrene oxide) in the copolymers, was similar for all four drugs. The highest solubilisation capacities were found for a copolymer with worm-like micelles.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Crothers
authors.forename: Nagíla M P S
authors.initials: NM
authors.lastname: Ricardo
authors.forename: Frank
authors.initials: F
authors.lastname: Heatley
authors.forename: S Keith
authors.initials: SK
authors.lastname: Nixon
authors.forename: David
authors.initials: D
authors.lastname: Attwood
authors.forename: Colin
authors.initials: C
authors.lastname: Booth
mesh_terms: D002074:Butanones / Q000737:chemistry; D005665:Furosemide / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D000077430:Nabumetone; D004364:Pharmaceutical Preparations / Q000737:chemistry; D019999:Pharmaceutical Solutions; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D011137:Polystyrenes / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002074:Butanones; D008823:Micelles; D004364:Pharmaceutical Preparations; D019999:Pharmaceutical Solutions; D011108:Polymers; D011137:Polystyrenes; C103390:polyethylene glycol-polystyrene; D011092:Polyethylene Glycols; D005665:Furosemide; D000077430:Nabumetone