title: Fluoride uptake by plaque from water and from dentifrice.
abstract: It has been suggested that fluoride retention in plaque is limited by available binding sites. We determined the effects of fluoridated or placebo dentifrices on plaque and salivary fluoride concentrations [F]s in communities with different water fluoride concentrations (0.04, 0.85, 3.5 ppm). After one week of dentifrice use, samples were collected 1.0 and 12 hrs after the last use of dentifrices. After the use of fluoridated dentifrice, plaque fluoride concentrations were higher at both times, except at 12 hrs in the 3.5-ppm community. Plaque concentrations at 1.0 hr after the use of fluoridated dentifrice increased almost constantly (6.5 mmol/kg), but then decreased approximately 50% at 12 hrs in each community. Unlike previous studies, the present findings suggest that the use of fluoridated dentifrice is likely to increase plaque fluoride concentrations significantly for up to 12 hrs in areas where the water contains fluoride close to 1.0 ppm. As previously reported, plaque fluoride concentrations were directly related to calcium concentrations.
authors.affiliation: Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru Dental School, University of São Paulo-Bauru, SP, Brazil.
authors.forename: J P
authors.initials: JP
authors.lastname: Pessan
authors.forename: S M B
authors.initials: SM
authors.lastname: Silva
authors.forename: J R P
authors.initials: JR
authors.lastname: Lauris
authors.forename: F C
authors.initials: FC
authors.lastname: Sampaio
authors.forename: G M
authors.initials: GM
authors.lastname: Whitford
authors.forename: M A R
authors.initials: MA
authors.lastname: Buzalaf
mesh_terms: D000704:Analysis of Variance; D002118:Calcium / Q000378:metabolism; D002327:Cariostatic Agents / Q000493:pharmacokinetics*; D002648:Child; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000378:metabolism*; D003802:Dentifrices / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005457:Fluoridation; D005460:Fluorides, Topical / Q000493:pharmacokinetics*; D006801:Humans; D012463:Saliva / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D005460:Fluorides, Topical; D002118:Calcium