Ionophoric properties of atropine: complexation and transport of Na+, K+, Mg2+ and Ca2+ ions across a liquid membrane.
The activity of atropine on the complexation and transport of Na(+), K(+), Mg(2+) and Ca(2+) ions across a liquid membrane was investigated using a spectrophotometric method. Atropine is a natural drug that blocks muscarinic receptors. It is a competitive antagonist of the action of acetylcholine and other muscarinic agonists. Atropine is shown to extract Na(+), K(+), Mg(2+) and Ca(2+) ions from an aqueous phase into an organic one with a preference for Ca(2+) ions. According to a kinetic study, divalent cations (Mg(2+) and Ca(2+)) are more rapidly transported than monovalent ones (Na(+) and K(+)). In both complexation and transport, the flux of the ions increases with the increase of atropine concentration. Atropine might act on the membrane permeability; its complexation and ionophoric properties shed new lights on its therapeutic properties.
Rabi
Latifa
L
Unit of Bio-industry and Molecular Toxicology, Laboratory of Microbiology, Biotechnology and Environment, Faculty of Sciences Aïn Chock, University Hassan II-Aïn Chock, Morocco.
Moutaouakkil
Adnane
A
Blaghen
Mohamed
M
D001285:Atropine / Q000737:chemistry* / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism; D002412:Cations; D002725:Chloroform / Q000737:chemistry; D007476:Ionophores / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D008274:Magnesium / Q000737:chemistry* / Q000378:metabolism; D008567:Membranes, Artificial; D010851:Picrates / Q000737:chemistry; D011188:Potassium / Q000737:chemistry* / Q000378:metabolism; D012964:Sodium / Q000737:chemistry* / Q000378:metabolism
D002412:Cations; D007476:Ionophores; D008567:Membranes, Artificial; D010851:Picrates; D001285:Atropine; D002725:Chloroform; D012964:Sodium; C005858:picric acid; D008274:Magnesium; D011188:Potassium; D002118:Calcium