title: Prospects for the use of differentiation-modulating agents as adjuvant of photodynamic therapy for proliferative dermatoses.
abstract: Current interest in photodynamic therapy (PDT) in dermatology stems from its recognized success in dermatological oncology, straightforward approach, easy accessibility and low cost. PDT is a photochemistry-based modality in which a light-activated photosensitizer (PS) destroys tissue through oxygen-dependent and -independent mechanisms. Although PDT has been used in dermatology for several decades, its application has still not extended significantly into the routine management of neoplastic and proliferative dermatoses because of continuing issues with the selectivity of the PS for affected tissues. This review analyzes prospects for optimization of PDT for the management of dermatoses with defects in keratinocyte proliferation/differentiation, and discusses the use of differentiating agents that redirect metabolic utilization within cells and lead to high levels of PS accumulation.
authors.affiliation: Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
authors.forename: Oleg E
authors.initials: OE
authors.lastname: Akilov
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kosaka
authors.forename: Edward V
authors.initials: EV
authors.lastname: Maytin
authors.forename: Tayyaba
authors.initials: T
authors.lastname: Hasan
mesh_terms: D017024:Chemotherapy, Adjuvant; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D010778:Photochemotherapy; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D003879:Dermatologic Agents; D007155:Immunologic Factors