A case of granuloma in the occipital lobe of a patient with Wegener's granulomatosis.
We report a case of Wegener's granulomatosis (WG) with central nervous system (CNS) involvement in a woman who complained of bilateral visual disturbance. The intracranial necrotizing granulomatous lesion was confirmed by MR imaging and brain biopsy. After high-dose oral corticosteroid treatment, not only clinical manifestations but also laboratory tests improved. Moreover, the CNS lesion completely regressed. This suggests that high-dose corticosteroid alone might be effective in treating WG with CNS involvement.
Azuma
Naoto
N
Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. naoazuuh@hyo-med.ac.jp
Katada
Yoshinori
Y
Nishimura
Nobumasa
N
Yamada
Tomonori
T
Uranishi
Ryunosuke
R
Nakatsuka
Shinichi
S
Dehara
Makoto
M
Harada
Yoshinori
Y
Yamanaka
Takao
T
Saeki
Yukihiko
Y
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D020293:Vasculitis, Central Nervous System / Q000188:drug therapy / Q000473:pathology*
D000893:Anti-Inflammatory Agents; D011239:Prednisolone