title: [Mucosal involvement in lymphomatoid papulosis: four cases].
abstract: BACKGROUND
  Lymphomatoid papulosis is a form of CD30+ cutaneous lymphoproliferation characterized by a benign chronic papulonodular eruption that regresses spontaneously. The clinical features contrast with the malignant histological aspect of lesions. Mucosal lesions are rare, with less than 10 published cases. We report four new cases and we highlight characteristic features of lesions at this particular site.
  
  
  METHODS
  We report four cases of mucous lymphomatoid papulosis in three women aged 37, 38, and 71 years and one 66-year-old man. These cases were collated from three different hospitals: Orléans, Rouen and Caen. Mucosal lesions occurred after cutaneous eruption in two cases but remained isolated or preceded cutaneous lesions in the other two cases. The main site was the mouth in all four cases but one case also involved genital lesions. Two cases involved type A pathological features and two had type C features. Association with lymphoma was excluded on clinical, laboratory and radiological examination. One patient was treated with methotrexate (>7.5mg/week) and did not relapse. Of the three other untreated patients only one did not relapse (short 14-month follow-up).
  
  
  CONCLUSIONS
  Recurrent oral ulcerations may be mucosal manifestations of lymphomatoid papulosis. This site does not appear to have any bearing on prognosis.
authors.affiliation: Service de dermatologie, centre hospitalier universitaire de Caen, avenue Georges-Clémenceau, 14033 Caen cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Allabert
authors.forename: E
authors.initials: E
authors.lastname: Estève
authors.forename: P
authors.initials: P
authors.lastname: Joly
authors.forename: X
authors.initials: X
authors.lastname: Troussard
authors.forename: F
authors.initials: F
authors.lastname: Comoz
authors.forename: P
authors.initials: P
authors.lastname: Courville
authors.forename: A
authors.initials: A
authors.lastname: Morice
authors.forename: L
authors.initials: L
authors.lastname: Verneuil
authors.forename: D
authors.initials: D
authors.lastname: Leroy
authors.forename: A
authors.initials: A
authors.lastname: Dompmartin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017731:Lymphomatoid Papulosis / Q000473:pathology*; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology*; D009297:Nasal Mucosa / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology*