[Lentiviral vectors and advance in its application].
Lentiviral vectors (Lv), known as holding lots of virtues (e.g. transfection to the dividing or non-dividing cells;large capacity of transfer gene fragments; long-term expression transfer genes; and low rate of immunological response) has come to be one of the hot-spots in gene therapy research. In this paper, taking the Lv derived from HIV-1 for example, we review the characteristics of frame, the developments and the advances in application of Lv.
Chu
Bo
B
School of Life Science of Southwest University, Chongqing 400715, China.
Huang
Xuefeng
X
Tang
Yunming
Y
D000818:Animals; D030801:Animals, Genetically Modified; D015316:Genetic Therapy / Q000379:methods / Q000639:trends*; D005822:Genetic Vectors / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D034741:RNA, Small Interfering / Q000235:genetics; D014161:Transduction, Genetic / Q000379:methods
D034741:RNA, Small Interfering