title: Screening of a Saccharomyces cerevisiae nonessential gene deletion collection for altered susceptibility to a killer peptide.
abstract: Approximately 4,800 Saccharomyces cerevisiae mutants deleted for nonessential genes were screened for alterations in susceptibility to a synthetic killer peptide (KP). None of the tested strains, including mutants resistant to conventional antifungal drugs, showed increased or decreased susceptibility to KP in comparison with the parental strain. The results may reflect the peculiar mechanism of action of KP and claim the possible avoidance of vital resistant mutants.
authors.affiliation: Dipartimento di Patologia e Medicina di Laboratorio, Sezione di Microbiologia, University of Parma, Parma, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Conti
authors.forename: Walter
authors.initials: W
authors.lastname: Magliani
authors.forename: Laura
authors.initials: L
authors.lastname: Giovati
authors.forename: Irene
authors.initials: I
authors.lastname: Libri
authors.forename: Domenico Leonardo
authors.initials: DL
authors.lastname: Maffei
authors.forename: Antonella
authors.initials: A
authors.lastname: Salati
authors.forename: Luciano
authors.initials: L
authors.lastname: Polonelli
mesh_terms: D017353:Gene Deletion; D055646:Killer Factors, Yeast; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009183:Mycotoxins / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C089359:K1 killer toxin; D055646:Killer Factors, Yeast; D009183:Mycotoxins; D010455:Peptides; D029701:Saccharomyces cerevisiae Proteins