title: Chemotherapy-induced acral erythema in a pediatric patient with acute monoblastic leukemia.
abstract: Chemotherapy-induced acral erythema or palmoplantar erythrodysesthesia syndrome is a well-defined reaction to some of the chemotherapeutic agents such as methotrexate, cytarabine, doxorubicin, fluorouracil, and bleomycin. This reaction is characterized by symmetrical, well-demarcated, painful erythema of the palms and soles, which may progress to desquamation. The authors present a case of acral erythema in a young patient with acute monoblastic leukemia to emphasize this high-dose chemotherapy-induced side effect, which is rarely seen in children and is usually self-limited.
authors.affiliation: Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. fatih.demircioglu@deu.edu.tr
authors.forename: Fatih
authors.initials: F
authors.lastname: Demircioğlu
authors.forename: Hale
authors.initials: H
authors.lastname: Oren
authors.forename: Sebnem
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Seçil
authors.initials: S
authors.lastname: Arslansoyu
authors.forename: Sanem
authors.initials: S
authors.lastname: Eren
authors.forename: Gülersu
authors.initials: G
authors.lastname: Irken
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005528:Foot / Q000473:pathology; D006225:Hand / Q000473:pathology; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D003561:Cytarabine; D001761:Bleomycin; D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate