title: CNS Lyme disease manifestation in children.
abstract: BACKGROUND
  Neurological symptoms develop in 10-20% of children with borreliosis.
  
  
  OBJECTIVE
  It was a presentation of clinical manifestation of neuroborreliosis in children.
  
  
  METHODS
  Children with neuroborreliosis and other neurological diseases were admitted to the University Hospital during 2005-2006 without any selection. Of these 9 patients, there were seven males and two females, ranging in age between 3-17 years. Neurological diagnostic was performed using ELISA Biomedica kit and western blot bands. A 2-6 week sequential treatment with either i.v. ceftazidime or amoxicillin and oral doxycycline or amoxicillin was provided. Children were monitored regularly during the next 4-24 months.
  
  
  RESULTS
  The 9 children with borreliosis constitute 0.53% of the pediatric neurology department's patients. The clinical manifestation of LD were usual and unusual from patient to patient. They included three cases of facial nerve paralysis (with bilateral paralysis in one case). In two cases, they included transverse myelitis and in a single case, hemiparesis, meningitis and acute ataxia. Typically, other patients with early stage borreliosis first manifest focal seizures, raising the suspicion that borreliosis could be responsible for triggering seizures. The antibiotic treatment was successful in 7 patients and only partially effective in 2 children with facial nerve paralysis.
  
  
  CONCLUSIONS
  The most common symptom of neuroborreliosis in children is motor dysfunction. Acute ataxia may be a clinical presentation of neuroborreliosis. It is probable that borreliosis_triggers seizures in children with EEG abnormalities.
authors.affiliation: Department of Pediatric Neurology, Jagiellonian University, Krakow, Poland. neupedkr@cm-uj.krakow.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Kaciński
authors.forename: Anna
authors.initials: A
authors.lastname: Zajac
authors.forename: Barbara
authors.initials: B
authors.lastname: Skowronek-Bała
authors.forename: Sławomir
authors.initials: S
authors.lastname: Kroczka
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gergont
authors.forename: Alicja
authors.initials: A
authors.lastname: Kubik
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015153:Blotting, Western; D002442:Ceftazidime / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D010243:Paralysis / Q000209:etiology; D012640:Seizures / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D002442:Ceftazidime