A digenic combination of polymorphisms within ESR1 and ESR2 genes are associated with age at menarche in the Spanish population.
In the present study, the authors look at an association of genetic variants within estrogen synthesis and signaling pathways and age at menarche (AAM) in Spanish women. They analyzed 9 polymorphisms in 6 different genes in 714 well-characterized postmenopausal women from Spain. They performed a quantitative trait locus study of these markers individually or in digenic combinations in relation to AAM. None of the studied markers, with the exception of the follicle-stimulating hormone receptor (P = .013), were significantly associated with AAM in the Spanish population, and no marker demonstrated an association of statistical significance after multiple testing corrections (P > .0055). In contrast, linear regression analysis suggests epistatic interactions including ESR1 and ESR2 loci in relation to AAM in the series (P = .003). The results suggest that epistatic interactions of ESR1 and ESR2 alleles could be associated with advancing AAM among Spanish women.
Mendoza
Nicolás
N
Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Morón
Francisco Jesús
FJ
Quereda
Francisco
F
Vázquez
Francisco
F
Rivero
Mari C
MC
Martínez-Astorquiza
Txantón
T
Real
Luis M
LM
Sánchez-Borrego
Rafael
R
González-Pérez
Antonio
A
Ruiz
Agustín
A
D000293:Adolescent; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D002648:Child; D004843:Epistasis, Genetic; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000235:genetics* / Q000378:metabolism; D004967:Estrogens / Q000096:biosynthesis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008572:Menarche / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013030:Spain
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens