title: Primary cutaneous aspergillosis in a patient with a solid organ transplant: case report and review of the literature.
abstract: OBJECTIVE
  To understand primary cutaneous aspergillosis to better manage patients with the condition.
  
  
  OBJECTIVE
  Upon completion of this activity, dermatologists and general practitioners should be able to: 1. Describe risk factors for Aspergillus infection. 2. Identify diagnostic methods for primary cutaneous aspergillosis. 3. Discuss treatment options for primary cutaneous aspergillosis. Primary cutaneous aspergillosis is an uncommon disease in immunocompetent individuals that often affects immunosuppressed hosts. We present the first reported case of primary cutaneous aspergillosis in a solid organ transplant recipient caused by Aspergillus niger. Fruiting bodies were isolated from a necrotic ulcer arising in a surgical wound. Debridement alone failed to resolve the infection, emphasizing the need for early antifungal treatment combined with surgical management of this infection.
authors.affiliation: Department of Dermatology, Vanderbilt University Medical Center, The Vanderbilt Clinic, Nashville, TN 37232, USA. lacey.m.thomas@vanderbilt.edu
authors.forename: Lacey M
authors.initials: LM
authors.lastname: Thomas
authors.forename: Heidi K
authors.initials: HK
authors.lastname: Rand
authors.forename: Jami L
authors.initials: JL
authors.lastname: Miller
authors.forename: Alan S
authors.initials: AS
authors.lastname: Boyd
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D003646:Debridement; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000276:immunology / Q000382:microbiology* / Q000628:therapy
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D000666:Amphotericin B