title: Preclinical models to evaluate potential pharmacotherapeutic agents in treating alcoholism and studying the neuropharmacological bases of ethanol-seeking behaviors in rats.
abstract: The unit outlines four basic protocols designed to systematically evaluate the capacity of potential pharmacotherapeutic agents to effectively treat alcohol addiction and dependence in rats. Also included are procedures designed to study the neural mechanisms regulating alcohol-seeking behaviors.
authors.affiliation: Indiana University-Purdue University, Indianapolis, Indiana, USA.
authors.forename: Harry L
authors.initials: HL
authors.lastname: June
mesh_terms: D000428:Alcohol Drinking / Q000188:drug therapy / Q000523:psychology; D000437:Alcoholism / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D000818:Animals; D016739:Behavior, Addictive / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012055:Reinforcement Schedule
chemical_list: D000431:Ethanol; D009271:Naltrexone; C038981:nalmefene