Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease.
BACKGROUND
Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups.


METHODS
Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n=557) undergoing elective coronary angiography.


RESULTS
MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p>0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r=0.132, p=0.002 and r=0.106, p=0.011, respectively).


CONCLUSIONS
In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.
Kubala
Lukas
L
Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA, USA. kubalal@ibp.cz
Lu
Guijing
G
Baldus
Stephan
S
Berglund
Lars
L
Eiserich
Jason P
JP
D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood* / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism
D009195:Peroxidase