Association of 1,5-anhydroglucitol and 2-h postprandial blood glucose in type 2 diabetic patients.
OBJECTIVE
To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.


METHODS
In 55 patients, we examined self-measured postprandial blood glucose values for correlations with 1,5-AG values over prespecified preceding time periods (3 days, 1 week, and weekly up to 12 weeks).


RESULTS
The correlation coefficients for postprandial glucose values were -0.34 (P < 0.05) for 3 days, -0.38 (P < 0.001) for 1 week, and -0.40 (P < 0.001) for 2 weeks preceding the measurement of 1,5-AG. Correlations declined for time periods >2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time dependency for the correlation between A1C and fasting or postprandial glucose.


CONCLUSIONS
1,5-AG best reflected the 2-h postprandial glucose values of the 2 previous weeks.
Stettler
Christoph
C
Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, Bern, Switzerland. christoph.stettler@insel.ch
Stahl
Matthias
M
Allemann
Sabin
S
Diem
Peter
P
Schmidlin
Kurt
K
Zwahlen
Marcel
M
Riesen
Walter
W
Keller
Ulrich
U
Christ
Emanuel
E
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D003847:Deoxyglucose / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005215:Fasting; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008875:Middle Aged; D010045:Outpatients; D019518:Postprandial Period; D015203:Reproducibility of Results; D013557:Switzerland
D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose