title: Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses.
abstract: Analysis of UV filter levels in 48 cataractous human lenses was performed with the use of HPLC. A new chromophore with the absorption maximum at 410nm and molecular mass of 369Da was detected and assigned as deaminated 3-hydroxykynurenine O-beta-D-glucoside (3OHCKAG). Cataractous lenses are characterized by the wide range of the UV filter concentrations and remarkably lower levels of UV filters and glutathione than published for the normal lenses. No correlation between the lens age and the level of UV filters has been found in cataractous lenses.
authors.affiliation: Department of Multispin Coordination Compounds, International Tomography Center SB RAS, Institutskaya 3a, Novosibirsk 630090, Russian Federation.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Snytnikova
authors.forename: Anjella Zh
authors.initials: AZh
authors.lastname: Fursova
authors.forename: Elena I
authors.initials: EI
authors.lastname: Chernyak
authors.forename: Vladimir G
authors.initials: VG
authors.lastname: Vasiliev
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Morozov
authors.forename: Nataliya G
authors.initials: NG
authors.lastname: Kolosova
authors.forename: Yuri P
authors.initials: YP
authors.lastname: Tsentalovich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003641:Deamination; D005960:Glucosides / Q000032:analysis* / Q000737:chemistry; D005978:Glutathione / Q000032:analysis; D006801:Humans; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D007908:Lens, Crystalline / Q000737:chemistry*; D008875:Middle Aged; D014466:Ultraviolet Rays
chemical_list: D005960:Glucosides; C029366:hydroxykynurenine glucoside; D007737:Kynurenine; D005978:Glutathione