The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats.
OBJECTIVE
This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats.


METHODS
Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg(-1) day(-1)) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week.


RESULTS
At the second, fourth, and eighth week, peripheral blood glucose levels in Group B were similar to those of Group C, which were much higher than those of Group A. Serum MCP-1 and ICAM-1 levels in Groups B and C were higher than those of Group A (P<.01), and serum MCP-1 and ICAM-1 levels in Group C were lower than those of Group B (P<.01); HbA1c was not significantly different between Group C and Group B.


CONCLUSIONS
Simvastatin has the effect of anti-inflammation, which may play some protection against the progress of atherosclerosis in diabetic rats.
Lin
Yang
Y
Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, 230001, China.
Ye
Shandong
S
Chen
Yan
Y
Li
Xiucai
X
Yang
Guang-wei
GW
Fan
Aihong
A
Wang
Yingxin
Y
D000818:Animals; D018932:Chemokine CCL2 / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology
D018932:Chemokine CCL2; D018799:Intercellular Adhesion Molecule-1; D019821:Simvastatin