In vitro models of human T cell anergy.
T cell anergy (acquired unresponsiveness) is an important mechanism for tolerance of self antigens. Human helper T cell clones rendered anergic in vitro are valuable tools for studying the molecular mechanisms of T cell tolerance. This unit outlines the induction and assessment of anergy in human CD4+ helper T cell clones that are reactive against MHC class II alloantigens.
Appleman
Leonard J
LJ
Harvard Medical School, Boston, Massachusetts, USA.
Boussiotis
Vassiliki
V
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D017635:Clonal Anergy; D002999:Clone Cells; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007519:Isoantigens; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007519:Isoantigens