Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
McCubrey
James A
JA
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA. mccubreyj@ecu.edu
Sokolosky
Melissa L
ML
Lehmann
Brian D
BD
Taylor
Jackson R
JR
Navolanic
Patrick M
PM
Chappell
William H
WH
Abrams
Stephen L
SL
Stadelman
Kristin M
KM
Wong
Ellis W T
EW
Misaghian
Negin
N
Horn
Stefan
S
Bäsecke
Jörg
J
Libra
Massimo
M
Stivala
Franca
F
Ligresti
Giovanni
G
Tafuri
Agostino
A
Milella
Michele
M
Zarzycki
Marek
M
Dzugaj
Andrzej
A
Chiarini
Francesca
F
Evangelisti
Camilla
C
Martelli
Alberto M
AM
Terrian
David M
DM
Franklin
Richard A
RA
Steelman
Linda S
LS
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D005260:Female; D006801:Humans; D053858:Metabolic Networks and Pathways; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D011494:Protein Kinases / Q000187:drug effects / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D058570:TOR Serine-Threonine Kinases; D014407:Tumor Cells, Cultured; D048490:raf Kinases / Q000502:physiology
D018931:Antineoplastic Agents, Hormonal; D004317:Doxorubicin; D048049:Extracellular Signal-Regulated MAP Kinases; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; D048490:raf Kinases; C546842:MTOR protein, human; C494929:PTEN protein, human