title: Cognitive and academic consequences of stem-cell transplantation in children.
abstract: OBJECTIVE
  To describe cognitive and academic outcomes in survivors after pediatric stem-cell transplantation (SCT) through 5-years post-SCT.
  
  
  METHODS
  A battery of neurocognitive measures were administered before admission and at 1, 3, and 5 years post-SCT for 268 patients who underwent SCT; the study sample is comprised of 158 patients who survived and were evaluated at 1-year post-SCT. Random coefficient models were generated to depict change over time, and to test differences in slope and intercept for medical and demographic predictor variables.
  
  
  RESULTS
  In the cohort as a whole, no significant changes were seen in global intelligence quotient and academic achievement. Despite the overall stability, some significant differences in slopes were found based on diagnosis, type of transplantation, use of total-body irradiation (TBI), and presence of graft-versus-host disease (GVHD). However, these differences were small, and of limited clinical significance. In comparison, differences as a function of socioeconomic status (SES) were much larger. SES was a significant determinant of all cognitive and academic outcomes, and the effect size generally dwarfed that of other significant predictor variables. Age, which had previously been identified as an important determinant of outcome, was not significantly predictive of outcome in this cohort.
  
  
  CONCLUSIONS
  The procedure of SCT entails minimal risk of late cognitive and academic sequelae. Subgroups of patients are at relatively higher risk: patients undergoing unrelated donor transplantation, receiving TBI, and those who experience GVHD. However, these differences are small relative to differences in premorbid functioning, particularly those associated with SES.
authors.affiliation: Division of Behavioral Medicine, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105-2794, USA. sean.phipps@stjude.org
authors.forename: Sean
authors.initials: S
authors.lastname: Phipps
authors.forename: Shesh N
authors.initials: SN
authors.lastname: Rai
authors.forename: Wing-Hang
authors.initials: WH
authors.lastname: Leung
authors.forename: Shelly
authors.initials: S
authors.lastname: Lensing
authors.forename: Maggi
authors.initials: M
authors.lastname: Dunavant
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007361:Intelligence Tests; D008137:Longitudinal Studies; D008297:Male; D009369:Neoplasms / Q000628:therapy*