Entecavir therapy induces de novo HIV reverse-transcriptase M184V mutation in an antiretroviral therapy-naive patient.
Recently, entecavir was introduced as a potent drug against hepatitis B virus infection. Initially, it was suggested not to have any effect on human immunodeficiency virus (HIV) infection. This guideline was revised in 2007 because of a report showing that the M184V mutation was selected in an hepatitis B virus and HIV-coinfected patient previously treated with lamivudine. Our investigation revealed findings similar to those preveiously reported but in an antiretroviral therapy-naive patient coinfected with HIV and hepatitis B virus. After 26 weeks of entecavir therapy, the M184V mutation dominated the plasma viral population. Thus, entecavir should only be used for coinfected patients who simultaneously receive suppressive therapy against HIV infection.
Jakobsen
Martin R
MR
Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. mrj@sks.aaa.dk
Arildsen
Hanne
H
Krarup
Henrik B
HB
Tolstrup
Martin
M
Østergaard
Lars
L
Laursen
Alex L
AL
D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000187:drug effects*; D010802:Phylogeny; D054299:env Gene Products, Human Immunodeficiency Virus / Q000145:classification / Q000235:genetics
D019380:Anti-HIV Agents; D054299:env Gene Products, Human Immunodeficiency Virus; C413685:entecavir; D006147:Guanine; D054303:HIV Reverse Transcriptase