Complete protection of sodium valproate from humidity by using a hydrotalcite composite.
Complete protection of sodium valproate from humidity was successfully accomplished by intercalation into a hydrotalcite-like compound. The obtained hybrid of sodium valproate and the hydrotalcite-like compound was stable and not at all hygroscopic. Even under a relative humidity of 97%, the adsorbed amount of water was less than 0.5%.
Nakayama
Hirokazu
H
Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan. hiro@kobepharma-u.ac.jp
Akasaka
Hiroko
H
Tsuhako
Mitsutomo
M
D000536:Aluminum Hydroxide / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D006813:Humidity / Q000517:prevention & control*; D008276:Magnesium Hydroxide / Q000737:chemistry*; D014635:Valproic Acid / Q000737:chemistry*
C010467:hydrotalcite; D000536:Aluminum Hydroxide; D014635:Valproic Acid; D008276:Magnesium Hydroxide