title: Usefulness of fibrinogen/fibrin degradation product to predict poor one-year outcome of medically treated patients with acute type B aortic dissection.
abstract: Previous studies have indicated that medical therapy provides excellent outcomes for patients with uncomplicated Stanford type B acute aortic dissection. However, affected aortas are often compromised by aneurysmal dilatation and rupture, resulting in poor outcomes. The purpose of this study was to determine predictors of aortic events in patients with Stanford type B acute aortic dissection receiving conservative medical therapy. The study group consisted of 78 consecutive patients with Stanford type B acute aortic dissection who were admitted to the hospital within 48 hours of onset. These patients were treated medically and followed up for 1 year. Aortic events were defined as rupture, recurrent dissection, aortic expansion with diameter>or=60 mm, rapid aortic expansion at a rate of >or=10 mm/yr, and the development of visceral or limb ischemia. Predictors of these events were determined using multivariate analyses. During 1-year follow-up, aortic events were observed in 13 (17%) patients, including aortic rupture in 3 (4%), aortic diameter>or=60 mm in 4 (5%), rapid expansion of the aorta in 3 (4%), and the development of visceral or limb ischemia in 3 (4%). On multivariate analysis, fibrinogen-fibrin degradation product level>or=20 microg/ml (odds ratio 7.802, 95% confidence interval 1.405 to 43.335) on admission was the only independent predictor of aortic events at 1 year. In conclusion, careful monitoring is required for patients with medically treated Stanford type B acute aortic dissection associated with fibrinogen-fibrin degradation product level>or=20 microg/ml on admission.
authors.affiliation: Department of Cardiology, National Cardiovascular Center, Suita, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kitada
authors.forename: Koichi
authors.initials: K
authors.lastname: Akutsu
authors.forename: Yuiichi
authors.initials: Y
authors.lastname: Tamori
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshimuta
authors.forename: Hideki
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeshita
mesh_terms: D000208:Acute Disease; D000368:Aged; D000784:Aortic Dissection / Q000097:blood* / Q000628:therapy*; D017542:Aneurysm, Ruptured / Q000097:blood* / Q000628:therapy*; D001014:Aortic Aneurysm / Q000097:blood* / Q000628:therapy*; D016009:Chi-Square Distribution; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D005338:Fibrin Fibrinogen Degradation Products