title: Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
abstract: The concentration of peripheral type benzodiazepine binding sites (PTBS) in the brain parenchyma is greatly increased following brain lesions, reflecting the glial reaction and/or presence of hematogenous cells. Thus, PTBS density is a sensitive and reliable marker of brain injury in a large number of experimental models (ischemia, trauma, excitotoxic lesions, brain tumors) and equivalent human neuropathological conditions. PTBS density can be measured using specific radioligands and a conventional binding technique, or by quantitative autoradiography in tissue sections.
authors.affiliation: Synthélabo Recherche, Bagneux Cédex, France.
authors.forename: J
authors.initials: J
authors.lastname: Benavides
authors.forename: A
authors.initials: A
authors.lastname: Dubois
authors.forename: B
authors.initials: B
authors.lastname: Scatton
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods*; D015415:Biomarkers; D001923:Brain Chemistry; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism; D002352:Carrier Proteins / Q000032:analysis*; D003292:Convulsants / Q000494:pharmacology / Q000633:toxicity; D007546:Isoquinolines / Q000032:analysis; D051379:Mice; D016202:N-Methylaspartate / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009498:Neurotoxins / Q000494:pharmacology / Q000633:toxicity; D011485:Protein Binding; D011869:Radioligand Assay / Q000379:methods*; D051381:Rats; D018079:Receptors, GABA / Q000032:analysis*; D011963:Receptors, GABA-A / Q000032:analysis*
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D003292:Convulsants; D007546:Isoquinolines; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D018079:Receptors, GABA; D011963:Receptors, GABA-A; C499229:TSPO protein, human; C069997:Tspo protein, rat; D016202:N-Methylaspartate; C037850:PK 11195