Animal models of retroviral encephalopathies: feline model.
Human immunodeficiency virus infection in children and adults results in a progressive neurodegenerative disease consistent with a predominant subcortical mediated dementia. Techniques for developing a feline model of the early stages of lentiviral-associated neurodegeneration are presented. The behavioral, neurophysiologic, immunologic, virologic, and neuropathologic aspects of this model are also described.
Podell
Michael
M
The Ohio State University, Columbus, Ohio, USA.
Buck
Wayne R
WR
Hayes
Kathleen A
KA
Gavrilin
Mikhail A
MA
Mathes
Lawrence E
LE
D000818:Animals; D002415:Cats / Q000276:immunology / Q000821:virology*; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*