title: Effectiveness of risperidone long-acting injection in first-episode schizophrenia: in naturalistic setting.
abstract: Patients with first-episode schizophrenia frequently relapse during the first years of the illness. This may be associated with clinical deterioration. It is important to prevent relapses in first-episode schizophrenia. We examine whether risperidone long-acting injection (RLAI) could effectively act to prevent relapse in first-episode schizophrenia. We conducted a prospective, naturalistic, controlled, and open-label study over 2 years in 50 patients with first-episode schizophrenia. 22 patients with schizophrenia were assigned to the RLAI group and 28 patients with schizophrenia to the oral risperidone group as control. We compared medication adherence, time to non-adherence, and relapse rate between the RLAI and control groups. There were no significant difference in sociodemographic findings and initial psychometric measures between two groups. The RLAI group showed significantly lower relapse rate and higher medication adherence than the control group. The result demonstrated by Kaplan-Meier survival analysis that time to non-adherence is associated with the difference in the groups. Cox proportional survival analysis revealed that time from baseline to relapse was associated with time to non-adherence. This result showed that RLAI could be effective in maintaining medication adherence and preventing relapse. However, studies with a larger sample size will be needed to examine whether these results are applicable to schizophrenic population.
authors.affiliation: Department of Psychiatry, Bundang CHA Hospital, Pochon CHA University College of Medicine, Seongnam, South Korea.
authors.forename: Borah
authors.initials: B
authors.lastname: Kim
authors.forename: Sang-Hyuk
authors.initials: SH
authors.lastname: Lee
authors.forename: Tae Kyou
authors.initials: TK
authors.lastname: Choi
authors.forename: ShinYoung
authors.initials: S
authors.lastname: Suh
authors.forename: Yong Woo
authors.initials: YW
authors.lastname: Kim
authors.forename: EunHee
authors.initials: E
authors.lastname: Lee
authors.forename: Ki Hwan
authors.initials: KH
authors.lastname: Yook
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018967:Risperidone / Q000008:administration & dosage* / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D016019:Survival Analysis
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone