title: Cytomegalovirus infection via mother's milk: could distinct virus strains determine different disease patterns in preterm twins?
abstract: We describe a case of cytomegalovirus infection via the mother's milk in preterm twins who showed a different disease pattern. Molecular analyses to genotype the viral genome disclosed a mixed population of virus strains in the milk. These isolates were differentially transmitted to each of the twins and this may be responsible of the different patterns of disease.
authors.affiliation: Department of Gynecological, Ostetrical and Pediatric Sciences, Clinical Unit of Neonatology, St. Orsola Malpighi General Hospital, University of Bologna, Bologna, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Lanari
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Capretti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Lazzarotto
authors.forename: Liliana
authors.initials: L
authors.lastname: Gabrielli
authors.forename: Sara
authors.initials: S
authors.lastname: Pignatelli
authors.forename: Paola
authors.initials: P
authors.lastname: Dal Monte
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Landini
authors.forename: Giacomo
authors.initials: G
authors.lastname: Faldella
mesh_terms: D000328:Adult; D001942:Breast Feeding / Q000009:adverse effects; D003587:Cytomegalovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000503:physiopathology / Q000635:transmission / Q000821:virology; D004200:Diseases in Twins / Q000503:physiopathology / Q000821:virology; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000821:virology; D019102:Infant, Very Low Birth Weight; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008895:Milk, Human / Q000821:virology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D014427:Twins