title: Pharmacokinetics and tissue distribution of anidulafungin in rats.
abstract: This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.
authors.affiliation: Pfizer Inc., New York, New York 10017, USA. bharat.damle@pfizer.com
authors.forename: Bharat
authors.initials: B
authors.lastname: Damle
authors.forename: Martin
authors.initials: M
authors.lastname: Stogniew
authors.forename: James
authors.initials: J
authors.lastname: Dowell
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001345:Autoradiography; D002177:Candidiasis / Q000188:drug therapy / Q000378:metabolism; D002250:Carbon Radioisotopes; D054714:Echinocandins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000935:Antifungal Agents; D002250:Carbon Radioisotopes; D054714:Echinocandins; D000077612:Anidulafungin