title: Mechanisms of asymmetric cell division: flies and worms pave the way.
abstract: Asymmetric cell division is fundamental for generating diversity in multicellular organisms. The mechanisms that govern asymmetric cell division are increasingly well understood, owing notably to studies that were conducted in Drosophila melanogaster and Caenorhabditis elegans. Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals.
authors.affiliation: Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology (EPFL), School of Life Sciences, Lausanne, Switzerland. Pierre.Gonczy@epfl.ch
authors.forename: Pierre
authors.initials: P
authors.lastname: Gönczy
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity; D018385:Centrosome / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology*; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000502:physiology; D044385:GTP-Binding Protein alpha Subunits / Q000378:metabolism; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism; D017510:Protein Folding; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D008941:Spindle Apparatus / Q000378:metabolism / Q000648:ultrastructure; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D044385:GTP-Binding Protein alpha Subunits; D015801:Helminth Proteins; D007605:Juvenile Hormones; D051880:Receptors, Notch; C060606:numb protein, Drosophila; D044767:Ubiquitin-Protein Ligases; C071006:neur protein, Drosophila