Overview of glycoconjugate analysis.
Whereas DNA, RNA, and proteins are linear polymers that can usually be directly sequenced, oligosaccharides show substantially more complexity,having branching and anomeric configurations (alpha and beta linkages). The biosynthesis of oligosaccharides, termed glycosylation, is extremely complex, is not template-driven, varies among different cell types, and cannot be easily predicted from simple rules. This overview discusses the stereochemistry of mono- and oligosaccharides and provides diagrammatic representations of monosaccharides (Fisher projections and Haworth representations) and formulas for representation of oligosaccharide chains. A glossary of terms used in glycobiology is also provided.
Varki
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University of California San Diego, La Jolla, California, USA.
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Manzi
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D000818:Animals; D002236:Carbohydrate Conformation; D003500:Cyclization; D004187:Disaccharides / Q000737:chemistry; D006001:Glycoconjugates / Q000737:chemistry*; D009005:Monosaccharides / Q000737:chemistry; D013237:Stereoisomerism
D004187:Disaccharides; D006001:Glycoconjugates; D009005:Monosaccharides