Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers.
Two experiments were conducted to determine whether methylphenidate or modafinil, two potential pharmacotherapies for stimulant dependence, would impair inhibitory behavior in cocaine users. Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions. A cued go-no-go task was used to measure response execution and inhibition. Subjective and cardiovascular measures were collected. Neither methylphenidate nor modafinil impaired inhibitory control, but produced prototypical subject-rated and cardiovascular effects. The results of these studies may have implications for the use of these drugs as agonist-replacement therapies for stimulant dependence.
Vansickel
Andrea R
AR
Department of Psychology, University of Kentucky, Lexington, Kentucky, USA.
Fillmorex
Mark T
MT
Hays
Lon R
LR
Rush
Craig R
CR
D000328:Adult; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D003042:Cocaine; D019970:Cocaine-Related Disorders / Q000534:rehabilitation; D003463:Cues; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects*; D000077408:Modafinil; D011930:Reaction Time / Q000187:drug effects
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D003042:Cocaine; D000077408:Modafinil