Role of probiotic therapy in IBD.
There is mounting evidence that probiotic therapy may alter disease expression in both animal models of IBD and in patients with IBD. The effects appear to be modest at best and may reflect the choice of probiotic organism, the variability in concentrations of organisms administered, and the variability of the diseases being treated. This review examines the data of all fully published articles currently available for the role of probiotics in the treatment of IBD.
Isaacs
Kim
K
University of North Carolina at Chapel Hill, Division of Gastroenterology and Hepatology, Chapel Hill, NC 27599-7032, USA. klisaacs@med.unc.edu
Herfarth
Hans
H
D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000628:therapy*; D003424:Crohn Disease / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000628:therapy; D008297:Male; D019449:Pouchitis / Q000382:microbiology / Q000517:prevention & control*; D019936:Probiotics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction / Q000379:methods; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome