[Research on relationship between angiotensinogen gene M235T and TCM syndrome type in essential hypertension patients].
OBJECTIVE
To explore the relationship between angiotensinogen (AGT) gene M235T and TCM syndrome type in essential hypertension (ET) patients.


METHODS
The gene mutation frequency of AGT M235T in 168 ET patients and 42 nomotensive (NT) subjects were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.


RESULTS
There was a significant difference in AGT M235T gene mutation between patients of Gan-fire exuberant type and those of yin-yang deficiency type (P < 0.01), homozygote type TT appeared with higher frequency. Multivariate regression linear analysis demonstrated that the genotypes of AGT M235T was correlated with the prognosis of ET to a certain degree.


CONCLUSIONS
Gene mutation of AGT M235T may be associated with the genesis and development of ET, and the TCM syndrome type of ET has its own intrinsic molecular biological background.
Wan
Ying-Xin
YX
Department of Geratology of TCM, China-Japan Friendship Hospital, BeiJing.
Zhang
Tie-Zhong
TZ
D000328:Adult; D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D002681:China; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D011110:Polymorphism, Genetic; D013577:Syndrome
D000808:Angiotensinogen