Glucose: a novel regulator of notch signaling.
Notch signaling regulates cell fate during the development of many tissues. A new Drosophila mutant, rumi, is defective in Notch signaling because it cannot add glucose to serine in epidermal growth factor repeats of Notch extracellular domain. This is the first biological role for glucose covalently attached to a cell surface signaling receptor.
Stanley
Pamela
P
Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA. stanley@aecom.yu.edu
D000818:Animals; D005947:Glucose / Q000378:metabolism*; D011485:Protein Binding; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
D051880:Receptors, Notch; D005947:Glucose