title: Scintillation proximity assay.
abstract: Scintillation proximity assay technologies provide a rapid non-separation method to measure common biological interactions using radioactively tagged molecules. This unit identifies potential uses of the technology for the measurement of receptor-ligand binding, cAMP accumulation, GTP binding to heterotrimeric G proteins, protease activity and cellular uptake.
authors.affiliation: Lilly Research Laboratories, Indianapolis, Indiana, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Kahl
authors.forename: Christian C
authors.initials: CC
authors.lastname: Felder
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D019204:GTP-Binding Proteins / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000378:metabolism; D012588:Scintillation Counting / Q000379:methods*; D012701:Serotonin / Q000493:pharmacokinetics; D018490:Serotonin Agents / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011985:Receptors, Serotonin; D018490:Serotonin Agents; C076396:serotonin 1E receptor; D012701:Serotonin; D000242:Cyclic AMP; D019204:GTP-Binding Proteins