title: A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle.
abstract: BACKGROUND
  Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo).
  
  
  RESULTS
  By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02).
  
  
  CONCLUSIONS
  Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul, 153-803, Korea. chhs@snp-genetics.com
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Du-Hak
authors.initials: DH
authors.lastname: Yoon
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Lyoung Hyo
authors.initials: LH
authors.lastname: Kim
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.forename: Sohg
authors.initials: S
authors.lastname: Namgoong
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Han
authors.forename: Ji On
authors.initials: JO
authors.lastname: Kim
authors.forename: Il-Cheong
authors.initials: IC
authors.lastname: Cheong
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000818:Animals; D002154:Calpain / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D005260:Female; D005838:Genotype; D007723:Korea; D008297:Male; D008460:Meat / Q000592:standards*; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D017422:Sequence Analysis, DNA
chemical_list: D002154:Calpain; C484807:CAPN1 protein, Bos taurus