title: Process improvement in amino acid N-carboxyanhydride synthesis by N-carbamoyl amino acid nitrosation.
abstract: Amino acid N-carboxyanhydrides (NCA), convenient monomer for polypeptide synthesis, are easily prepared in high purity as the result of N-carbamoyl amino acids (CAA) nitrosation by gaseous NOx (4:1 NO + O2 mixture, or NOCl) in toluene. Removal of polar side products is then efficiently carried out during subsequent work-up and crystallisation so that the resulting NCA obtained in good yield is suitable for controlled, primary amine-initiated polymerisation.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR 5247, CNRS, Université Montpellier 1, Université Montpellier 2, Montpellier, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lagrille
authors.forename: Grégoire
authors.initials: G
authors.lastname: Danger
authors.forename: Laurent
authors.initials: L
authors.lastname: Boiteau
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Rossi
authors.forename: Jacques
authors.initials: J
authors.lastname: Taillades
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000812:Anhydrides / Q000138:chemical synthesis*; D015538:Nitrosation
chemical_list: D000596:Amino Acids; D000812:Anhydrides