Quantitative EEG and cognitive evoked potentials in anemia.
OBJECTIVE
The anemic status may alter brain functions and electrogenesis, as reflected by EEG and cognitive EPs (CEPs). This study aims to evaluate CEPs and EEG power spectra in adult patients with iron-deficiency anemia and to determine the effects of appropriate iron therapy on electrodiagnostic findings.


METHODS
Fifty-one patients with iron-deficiency anemia underwent CEP and EEG recording. All patients were re-assessed after three months of oral-iron therapy.


RESULTS
All patients had recovered from their anemia through the three-month iron therapy. Central N1 amplitude and parietal P2 amplitude was increased. N2 latencies were shortened in frontal and central regions. P3 latencies were shortened in frontal, central and parietal areas and P3 amplitude was increased in the parietal region. Except in the gamma-band, all pretreatment and post-treatment mean-power values were significantly lower at the temporal, parietal and occipital regions.


CONCLUSIONS
This study indicates that in iron-deficiency anemia, appropriate iron therapy can improve brain electrogenesis, as reflected by P300 and EEG power spectra.
Kececi
H
H
Department of Neurology, Duzce University Medical Faculty, Duzce, Turkey. hulusikececi@dtip.edu.tr
Degirmenci
Y
Y
D000161:Acoustic Stimulation; D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D004566:Electrodes; D004569:Electroencephalography; D004585:Electrooculography; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D058085:Iron Compounds / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D006454:Hemoglobins; D058085:Iron Compounds