Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase.
Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (992-997) report a new player in HSC homeostasis, c-Cbl ubiquitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.
Yokomizo
Tomomasa
T
Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Dzierzak
Elaine
E
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D016207:Cytokines / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000201:enzymology*; D006706:Homeostasis; D051379:Mice; D050721:Proto-Oncogene Proteins c-cbl / Q000378:metabolism*; D015398:Signal Transduction
D016207:Cytokines; D050721:Proto-Oncogene Proteins c-cbl