title: Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis.
abstract: OBJECTIVE
  To investigate the feasibility of laparoscopic high-intensity focused ultrasound (HIFU) ablation in the treatment of patients with uterine localized adenomyosis.
  
  
  METHODS
  A prospective clinical trial.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Seven patients with uterine localized adenomyosis.
  
  
  METHODS
  Using a hand-held focused ultrasound transducer, the HIFU procedure was performed by the same gynecologist for the treatment of a targeted adenomyosis during the surgical procedure, followed by hysterectomy.
  
  
  METHODS
  Feasibility and effectiveness of HIFU treatment of localized adenomyomas.
  
  
  RESULTS
  Macroscopic and microscopic examinations showed that HIFU induced thermal ablation of a targeted adenomyosis in all patients. The treated adenomyosis presented typical characteristics of coagulation necrosis, and the margin between the treated and untreated regions was clear in 2,3,5-triphenyltetrazolium chloride staining. By using electronic microscopy and nicotinamide adenine dinucleotide-diaphorase stain, complete loss of cellular viability was identified in the treated tissue.
  
  
  CONCLUSIONS
  The HIFU treatment is feasible and effective in the treatment of patients with uterine localized adenomyosis. It may provide a promising laparoscopic treatment for localized adenomyosis.
authors.affiliation: Department of Obstetrics & Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China. cqyangz@vip.163.com
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yang
authors.forename: You-De
authors.initials: YD
authors.lastname: Cao
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Hu
authors.forename: Zhi-Biao
authors.initials: ZB
authors.lastname: Wang
mesh_terms: D016923:Cell Death; D004715:Endometriosis / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D009336:Necrosis; D011446:Prospective Studies; D014464:Ultrasonic Therapy / Q000379:methods*; D014591:Uterine Diseases / Q000473:pathology* / Q000628:therapy*; D014599:Uterus / Q000473:pathology / Q000648:ultrastructure