title: [Progress on biodegradation of polylactic acid--a review].
abstract: Polylactic acid is a high molecular-weight polyester made from renewable resources such as corn or starch. It is a promising biodegradable plastic due to its mechanical properties, biocompatibility and biodegradability. To achieve natural recycling of polylactic acid, relative microorganisms and the underlying mechanisms in the biodegradation has become an important issue in biodegradable materials. Up to date, most isolated microbes capable of degrading polylactic acid belong to actinomycetes. Proteases secreted by these microorganisms are responsible for the degradation. However, subtle differences exist between these polylactic acid degrading enzymes and typical proteases with respect to substrate binding and catalysis. Amino acids relative to catalysis are postulated to be highly plastic allowing their catalytic hydrolysis of polylactic acid. In this paper we reviewed current studies on biodegradation of polylactic acid concerning its microbial, enzymatic reactions and the possible mechanisms. We also discussed the probability of biologically recycling PLA by applying highly efficient strains and enzymes.
authors.affiliation: State Key Laboratory of Microbial Technology, University of Shandong, Jinan 250100, China. lifan0302@163.com
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.forename: Sha
authors.initials: S
authors.lastname: Wang
authors.forename: Weifeng
authors.initials: W
authors.lastname: Liu
authors.forename: Guanjun
authors.initials: G
authors.lastname: Chen
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D001673:Biodegradation, Environmental; D005656:Fungal Proteins / Q000378:metabolism; D005658:Fungi / Q000201:enzymology / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D011091:Polyesters; D011108:Polymers / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D005656:Fungal Proteins; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)