The synthesis of enantiomerically pure [2.2]paracyclophane derivatives.
[2.2]Paracyclophane is a fascinating molecule that offers great potential in a wide range of chemical disciplines. Currently, the synthesis of the majority of enantiomerically pure [2.2]paracyclophane derivatives is based on the resolution of a small number of starting materials or individual resolution procedures are developed for each new compound. The development of more general routes to these valuable compounds via the resolution of a common intermediate is discussed. Ultimately, it would be preferable to synthesise these valuable compounds without recourse to resolution and ideas for this rewarding goal are postulated.
Rowlands
Gareth J
GJ
Institute of Fundamental Sciences - Chemistry, Massey University, Private Bag 11 222, Palmerston North, New Zealand. g.j.rowlands@massey.ac.nz
D003500:Cyclization; D054879:Halogenation; D008968:Molecular Conformation; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry
D011083:Polycyclic Compounds; D013454:Sulfoxides; C515344:(2.2)paracyclophane