Involvement of nicotinic and muscarinic acetylcholine receptors on striatal HgCl2-induced dopamine release in freely moving rats.
The possible role of acetylcholine receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective nicotinic and muscarinic receptor antagonists, mecamylamine and atropine, respectively. Intrastriatal infusion of 1mM HgCl(2) increased striatal DA to 1717.2+/-375.4% respect to basal levels. Infusion of 1mM HgCl(2) in 1mM mecamylamine pretreated animals produced an increase on striatal DA levels 58% less than that induced in non-pretreated animals. In the case of atropine, this treatment reduced 62% the effect produced by HgCl(2) as compared to non-pretreated rats. These data show that acetylcholine receptors could participate on HgCl(2)-induced dopamine release since administration of nicotinic and muscarinic receptor antagonists reduces HgCl(2) effects on DA release.
Vidal
Lucía
L
Department of Functional Biology and Health Sciences, University of Vigo, Vigo, Spain. lvidal@uvigo.es
Durán
Rafael
R
Faro
Lilian R F
LR
Alfonso
Miguel
M
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D001285:Atropine / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004336:Drug Antagonism; D005260:Female; D008464:Mecamylamine / Q000494:pharmacology; D008627:Mercuric Chloride / Q000633:toxicity*; D017551:Microdialysis; D018727:Muscarinic Antagonists / Q000494:pharmacology; D018733:Nicotinic Antagonists / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*
D000891:Anti-Infective Agents, Local; D018727:Muscarinic Antagonists; D018733:Nicotinic Antagonists; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D008627:Mercuric Chloride; D008464:Mecamylamine; D001285:Atropine; D004298:Dopamine