Animal models of intraocular lymphomas.
Primary intraocular lymphoma is a high-grade non-Hodgkin lymphoma whose pathogenesis is still unclear. Few animal models exist in order to study this condition. Although intraocular lymphomas in humans are usually B cell lymphomas, most of these models are T cell lymphomas. Recently, a major step forward has been realized with the development of new models of intraocular B cell lymphoma. New therapeutic tools are being evaluated in these models of B cell lymphoma. We evaluate the contribution of the different animal models available to study intraocular lymphomas, and we discuss the new therapeutic strategies and their various targets in the tumor as well as in the environment, which are currently investigated through the development of these models.
Touitou
Valérie
V
Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Centre de Recherche des Cordeliers, Paris, France.
Bodaghi
Bahram
B
de Kozak
Yvonne
Y
Lehoang
Phuc
P
Sautès-Fridman
Catherine
C
Fisson
Sylvain
S
D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D005134:Eye Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009374:Neoplasms, Experimental
D016207:Cytokines