Fear-potentiated startle in rats.
Fear-potentiated startle measures the increase in the startle reflex elicited by a sudden noise in the presence of a cue that has previously been paired with footshock. It involves an initial training session in which a cue, such as a light, is paired with footshock, and then a later test session in which startle is elicited in the presence or absence of the cue. It thus involves associative learning, memory for that association measured during the retention test, and conditioned fear in the presence of the cue. Drugs that interfere with learning, memory, or fear and anxiety can alter fear-potentiated startle depending on when they are given with respect to training and testing.
Davis
M
M
Emory University School of Medicine, Atlanta, Georgia, USA.
D000161:Acoustic Stimulation / Q000009:adverse effects; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003463:Cues; D004597:Electroshock / Q000009:adverse effects; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D010775:Photic Stimulation / Q000009:adverse effects; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology* / Q000523:psychology; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity
D011619:Psychotropic Drugs