title: Factors associated with African Americans' enrollment in a national cancer genetics registry.
abstract: This study explored whether reactions to the Cancer Genetics Network (CGN) or CGN enrollment differed by receipt of a standard informational brochure versus a targeted version addressing factors previously associated with African Americans' health behavior decisions and research participation. The 262 participants, identified through tumor registries or clinic contacts, were mailed brochures and completed phone interviews. When asked whether - based on the brochure - they were or were not 'leaning toward' CGN enrollment, about 75% of both standard and targeted groups reported leaning toward. When given the opportunity at the end of the interview, 68% enrolled in the CGN. Trust was strongly related to enrollment. Less education, less satisfaction with cancer care, and individualistic rather than collective orientation were associated with lower trust. Education was also bivariately associated with enrollment, but mediation analysis indicated that the operational mechanism of education's influence on enrollment was through trust.
authors.affiliation: Duke Comprehensive Cancer Center, Durham, NC, USA. skinn008@mc.duke.edu
authors.forename: C S
authors.initials: CS
authors.lastname: Skinner
authors.forename: J M
authors.initials: JM
authors.lastname: Schildkraut
authors.forename: B
authors.initials: B
authors.lastname: Calingaert
authors.forename: C
authors.initials: C
authors.lastname: Hoyo
authors.forename: S S
authors.initials: SS
authors.lastname: Crankshaw
authors.forename: L
authors.initials: L
authors.lastname: Fish
authors.forename: L
authors.initials: L
authors.lastname: Susswein
authors.forename: C
authors.initials: C
authors.lastname: Jasper
authors.forename: L
authors.initials: L
authors.lastname: Reid
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics / Q000523:psychology*; D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D036281:Genetic Research; D006801:Humans; D008297:Male; D008495:Medical Oncology; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D010358:Patient Participation; D012042:Registries; D035502:Trust