title: Residual functional connectivity in the split-brain revealed with resting-state functional MRI.
abstract: Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
authors.affiliation: New York University Child Study Center, New York, NY 10016, USA. lucina.uddin@med.nyu.edu
authors.forename: Lucina Q
authors.initials: LQ
authors.lastname: Uddin
authors.forename: Eric
authors.initials: E
authors.lastname: Mooshagian
authors.forename: Eran
authors.initials: E
authors.lastname: Zaidel
authors.forename: Anouk
authors.initials: A
authors.lastname: Scheres
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Margulies
authors.forename: A M Clare
authors.initials: AM
authors.lastname: Kelly
authors.forename: Zarrar
authors.initials: Z
authors.lastname: Shehzad
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Adelstein
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Castellanos
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Biswal
authors.forename: Michael P
authors.initials: MP
authors.lastname: Milham
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004827:Epilepsy / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000502:physiology*; D050812:Split-Brain Procedure