title: Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial.
abstract: The behavioural and psychological impact of genetic testing for lung cancer susceptibility was examined among smokers (N = 61) who were randomly allocated to a GSTM1 genetic testing group (with GSTM1-missing or GSTM1-present result) or no-test control group. The GSTM1-missing (higher risk) group reported greater motivation to quit smoking, and both genetic testing groups reported lower depression than the control group at one-week follow-up (p < .05 for all). Differences were not significant at two months follow-up. This study indicates the feasibility of much-needed research into the risks and benefits for individuals of emerging lifestyle-related genetic susceptibility tests.
authors.affiliation: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, University College London, London, UK. s.sanderson@ucl.ac.uk
authors.forename: Saskia C
authors.initials: SC
authors.lastname: Sanderson
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
authors.forename: Christina
authors.initials: C
authors.lastname: Hubbart
authors.forename: Eluned
authors.initials: E
authors.lastname: Hughes
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Jarvis
authors.forename: Jane
authors.initials: J
authors.lastname: Wardle
mesh_terms: D000328:Adult; D000339:Affect; D005240:Feasibility Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015438:Health Behavior; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008967:Molecular Biology / Q000379:methods*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D011795:Surveys and Questionnaires