[Intervening effect of Qiangxin Fumai Granule on arrhythmia induced by right coronary artery ischemia/reperfusion in rabbits].
OBJECTIVE
To observe the development of arrhythmia induced by ischemia/reperfusion (I/R) of the right coronary artery in rabbits and the intervening effect of Chinese medicine Qiangxin Fumai Granule (QFG), a Chinese preparation for activating yang and promoting blood circulation, on it.


METHODS
Rabbit right coronary artery I/R model was adopted. Forty healthy adult rabbits were randomly divided into 5 groups, the sham-operation group, the model group, the atropine group, the high-dose QFG group, and the low-dose QFG group, eight in each group. The drugs were administered via duodenal perfusion 10 min after ischemia. The changes of AA interval before and after medication were observed and the scores of arrhythmia were calculated.


RESULTS
During ischemia period, AA interval prolonged for more than 40 ms in the model group, and the scores of arrhythmia showed a rising trend along with the prolonging of ischemia, with the presence of atrial-ventricular block (AVB) and aggravating of sinus and atrial arrhythmia; during reperfusion period, the incidence of AVB decreased, and AA interval somewhat decreased. The AA intervals and scores of arrhythmia in the high and low-dose QFG groups were significantly lower than those in the model group respectively (P < 0.01 or P < 0.05).


CONCLUSIONS
QFG is beneficial for shortening AA interval and preventing arrhythmia induced by I/R.
Tan
Shuang
S
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing.
Wang
Yan-Yun
YY
Liu
Ru-Xiu
RX
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000150:complications; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology*; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; C532896:qiangxin fumai