Transcriptional control of human p53-regulated genes.
The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
Riley
Todd
T
The Institute for Advanced Study, Princeton, New Jersey, USA. triley@ias.edu
Sontag
Eduardo
E
Chen
Patricia
P
Levine
Arnold
A
D001483:Base Sequence; D001665:Binding Sites; D002471:Cell Transformation, Neoplastic; D004249:DNA Damage; D005786:Gene Expression Regulation; D016158:Genes, p53; D006801:Humans; D008390:Markov Chains; D008969:Molecular Sequence Data; D050436:Regulatory Elements, Transcriptional; D012045:Regulatory Sequences, Nucleic Acid; D020218:Response Elements; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
D016159:Tumor Suppressor Protein p53