title: Exposure assessment of prepubertal children to steroid endocrine disruptors. 2. Determination of steroid hormones in milk, egg, and meat samples.
abstract: In the present study, the occurrence of the main sex steroid hormones in milk, egg, and meat was evaluated on the basis of a highly specific gas chromatography-tandem mass spectrometry measurement method. Globally, the results indicated that targeted estrogens and androgens occurred at similar levels (concentration levels in the 10-100 ng kg (-1) range) in the analyzed muscle and milk samples. The same compounds occurred at about 10-fold higher concentrations (i.e., in the 100-1000 ng kg (-1) range) in eggs and kidney samples. More precisely, egg and milk appeared as a non-negligible sources of estradiol (i.e., 2.2 +/- 0.8 and 3.1 +/- 2.0 ng day (-1), respectively), whereas testosterone exposure is caused by ingestion of meat and/or egg (i.e., 12.2 +/- 48.2 and 5.2 +/- 2.3 ng day (-1), respectively). The provided exposure data will be further exploited in the scope of a risk assessment study regarding endocrine disruption associated with these molecules.
authors.affiliation: Laboratoire d'Etude des Résidus et Contaminants dans les Aliments, Ecole Nationale Vétérinaire de Nantes, USC 2013 INRA, B P 50707, F-44307 Nantes, Cedex 3, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Courant
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.forename: Julie
authors.initials: J
authors.lastname: Laille
authors.forename: Fabrice
authors.initials: F
authors.lastname: Monteau
authors.forename: François
authors.initials: F
authors.lastname: Andre
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D000728:Androgens / Q000032:analysis; D000818:Animals; D002675:Child, Preschool; D004531:Eggs / Q000032:analysis*; D052244:Endocrine Disruptors / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D004781:Environmental Exposure; D004967:Estrogens / Q000032:analysis; D006801:Humans; D008460:Meat / Q000032:analysis*; D008892:Milk / Q000737:chemistry*; D011627:Puberty
chemical_list: D000728:Androgens; D052244:Endocrine Disruptors; D004967:Estrogens