The quest for the 1p36 tumor suppressor.
Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that their encoded products protect from cancer has been scanty. A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. Here, we discuss evidence supporting the tumor-suppressive role of CHD5. Together, these findings suggest that strategies designed to enhance CHD5 activity could provide novel approaches for treating a broad range of human malignancies.
Bagchi
Anindya
A
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Mills
Alea A
AA
D002843:Chromatin / Q000235:genetics; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004265:DNA Helicases / Q000235:genetics; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D009419:Nerve Tissue Proteins / Q000235:genetics; D017384:Sequence Deletion
D002843:Chromatin; D009419:Nerve Tissue Proteins; D004265:DNA Helicases; C471926:CHD5 protein, human