title: The strong MRI relaxivity of paramagnetic nanoparticles.
abstract: We developed a method to synthesize paramagnetic nanoparticles of Gd@C82(OH)22+/-2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12x MRI relaxivity of Gd@C82(OH)22+/-2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22+/-2 nanoparticles, approximately 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.
authors.affiliation: Lab for Bio-Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing, China.
authors.forename: Gengmei
authors.initials: G
authors.lastname: Xing
authors.forename: Hui
authors.initials: H
authors.lastname: Yuan
authors.forename: Rui
authors.initials: R
authors.lastname: He
authors.forename: Xueyun
authors.initials: X
authors.lastname: Gao
authors.forename: Long
authors.initials: L
authors.lastname: Jing
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Chai
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D005682:Gadolinium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D018625:Microscopy, Atomic Force; D053758:Nanoparticles
chemical_list: D005682:Gadolinium