The effect of air pollution on asthma and allergy.
Air pollution exposure is associated with increased asthma and allergy morbidity and is a suspected contributor to the increasing prevalence of allergic conditions. Observational studies continue to strengthen the association between air pollution and allergic respiratory disease, whereas recent mechanistic studies have defined the prominent role of oxidative stress in the proallergic immunologic effects of particulate and gaseous pollutants. The identification of common genetic polymorphisms in key cytoprotective responses to oxidative stress has highlighted the importance of individual host susceptibility to pollutant-induced inflammation. Future therapy to reduce the adverse effects of air pollution on allergic respiratory disease will likely depend on targeting susceptible populations for treatment that reduces oxidative stress, potentially through enhancement of phase 2 enzymes or other antioxidant defenses.
Riedl
Marc A
MA
Division of Pulmonary and Critical Care Medicine, UCLA-David Geffen School of Medicine, Los Angeles, CA 90095, USA. mriedl@mednet.ucla.edu
D000393:Air Pollutants / Q000276:immunology; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000276:immunology*; D004198:Disease Susceptibility; D004781:Environmental Exposure; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D052638:Particulate Matter / Q000276:immunology; D014504:Urban Health; D001335:Vehicle Emissions
D000393:Air Pollutants; D052638:Particulate Matter; D001335:Vehicle Emissions