title: The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs.
abstract: Chronically elevated interleukin-6 (IL-6) affects lipid and lipoprotein metabolism. Individuals genetically predisposed to higher IL-6 secretion may be at risk of dyslipidemia, especially during the postprandial phase. We investigated the effect of genetic variants at the IL6 locus on postprandial lipemia in US Whites participating in the Genetics of Lipid Lowering Drugs and Diet Network study. Subjects were given a single fat load composed of 3% of calories as protein, 14% as carbohydrate, and 83% as fat. Blood was drawn at 0 h, 3.5 h, and 6 h to determine plasma triglyceride (TG), TG-rich lipoprotein (TRL) and lipoprotein particle size. Homozygotes (GG) and heterozygotes (CG) of the -174C/G variant displayed higher plasma IL-6 concentrations compared with major allele homozygotes (CC) (P = 0.029). GG and CG subjects showed higher fasting plasma TG (P = 0.025), VLDL (P = 0.04), and large VLDL (P = 0.02) concentrations than did CC subjects. Moreover, GG and CG subjects experienced greater postprandial response of TG (P = 0.006) and TRL, including chylomicrons (P = 0.005), total VLDL (P = 0.029), and large VLDL (P = 0.017) than did CC subjects. These results suggest that the functional polymorphism -174C>G at the IL6 locus determines the difference in both fasting and postprandial TG metabolism. This phenomenon could be responsible for the observed association of this genetic variant with cardiovascular disease risk.
authors.affiliation: Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Donna K
authors.initials: DK
authors.lastname: Arnett
authors.forename: Pablo
authors.initials: P
authors.lastname: Pérez-Martínez
authors.forename: Laurence D
authors.initials: LD
authors.lastname: Parnell
authors.forename: Chao-Qiang
authors.initials: CQ
authors.lastname: Lai
authors.forename: James M
authors.initials: JM
authors.lastname: Peacock
authors.forename: James E
authors.initials: JE
authors.lastname: Hixson
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tsai
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Straka
authors.forename: Paul N
authors.initials: PN
authors.lastname: Hopkins
authors.forename: José M
authors.initials: JM
authors.lastname: Ordovás
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism*; D044465:White People / Q000235:genetics
chemical_list: D015850:Interleukin-6; D014280:Triglycerides