Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes.
The abundance of the adiponectin receptors, AdipoR1 and AdipoR2, and the effects of the antidiabetic adipokine adiponectin in monocytes of normal-weight and overweight controls and type 2 diabetic patients (T2D) were analyzed. AdipoR1 and AdipoR2 mRNAs were increased in monocytes of obese controls and T2D patients when compared to normal-weight controls, and AdipoR1 mRNA positively correlated to AdipoR2 mRNA, the waist to hip ratio and systemic adiponectin. However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal-weight donors. Induction of IL-6 and IL-8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes.
Weigert
Johanna
J
Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Neumeier
Markus
M
Wanninger
Josef
J
Wurm
Sylvia
S
Kopp
Andrea
A
Schober
Franziska
F
Filarsky
Michael
M
Schäffler
Andreas
A
Zeitoun
Martina
M
Aslanidis
Charalampos
C
Buechler
Christa
C
D052242:Adiponectin / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D054419:Receptors, Adiponectin / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015854:Up-Regulation; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D015850:Interleukin-6; D016209:Interleukin-8; D054419:Receptors, Adiponectin; D048051:p38 Mitogen-Activated Protein Kinases