Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.
Polymorphisms in a number of genes encoding for DNA repair enzymes have been associated with altering the function of these enzymes and increasing risk of a number of cancers, including colon cancer. We have investigated the association between a common variant in polynucleotide kinase 3' phosphatase (PNKP), a putative DNA repair enzyme, and risk of adenoma recurrence in the Polyp Prevention Trial participants. We also investigated possible interaction or effect modification between carriage of the variant allele, dietary components and risk of adenoma recurrence. Unconditional logistic regression models were used to calculate the odds ratios and 95% confidence intervals for an association between the G/T polymorphism, PNKP T5644G and risk of adenoma recurrence. We observed no association between carriage of the variant allele and risk of adenoma recurrence. Furthermore, we found no effect modification between genotype, dietary components and risk of adenoma recurrence. The PNKP T5644G variant does not seem to be involved in adenoma recurrence in the Polyp Prevention Trial.
Murphy
Gwen
G
Cancer Prevention Fellowship Program, Office of Preventive Oncology, Bethesda, Maryland, USA. murphygw@mail.nih.gov
Sansbury
Leah S
LS
Bergen
Andrew W
AW
Wang
Zhuoqiao
Z
Schatzkin
Arthur
A
Lehman
Teresa
T
Kalidindi
Aravind
A
Modali
Rama
R
Lanza
Elaine
E
D000236:Adenoma / Q000235:genetics* / Q000517:prevention & control; D000368:Aged; D003110:Colonic Neoplasms / Q000235:genetics* / Q000517:prevention & control; D003111:Colonic Polyps / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D045643:DNA Repair Enzymes / Q000235:genetics*; D004032:Diet / Q000009:adverse effects; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000517:prevention & control*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology
C530380:PNKP protein, human; D017853:Phosphotransferases (Alcohol Group Acceptor); D010744:Phosphoric Monoester Hydrolases; D045643:DNA Repair Enzymes