title: Nanoscale tools to selectively destroy cancer cells.
abstract: We present experimental data that demonstrate the potential of synthetic crown ether modified peptide nanostructures to act as selective and efficient chemotherapeutic agents that operate by attacking and destroying cell membranes.
authors.affiliation: Département de chimie and Centre de recherche sur la fonction, la structure et l'ingénierie des protéines, Faculté des sciences et génie, Université Laval, Québec, QC, CanadaG1K 7P4.
authors.forename: Pierre-Luc
authors.initials: PL
authors.lastname: Boudreault
authors.forename: Mathieu
authors.initials: M
authors.lastname: Arseneault
authors.forename: François
authors.initials: F
authors.lastname: Otis
authors.forename: Normand
authors.initials: N
authors.lastname: Voyer
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects*; D043844:Crown Ethers / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D043844:Crown Ethers; D010455:Peptides