title: Synthesis and anti-HIV studies of 2- and 3-adamantyl-substituted thiazolidin-4-ones.
abstract: A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2 or 3 were synthesized. A majority of them showed a modest anti-HIV-1 activity, whereas 2-adamantan-1-yl-3-(4,6-dimethylpyrimidin-2-yl)-thiazolidin-4-one (8) was endowed with a remarkable antiviral potency (EC(50)=0.67 microM). The new series of compounds (22-29) with an adamantyl moiety at the 3-position of the thiazolidinone ring showed good to modest anti-HIV-1 activity (EC(50)=1.0-11 microM) but also pronounced cytostatic activity. For example 24, 26 and 29 showed an EC(50) of 1.0-2.0 microM, while the 50% effective concentrations for 23 and 28 were 7.8 and 11.0 microM, respectively. X-ray studies and quantum chemical calculations revealed that the anti-HIV activity of the compounds strongly depends on their dipole moments and conformation of the thiazolidinones.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Barbara
authors.initials: B
authors.lastname: Orzeszko-Krzesińska
authors.forename: Jan K
authors.initials: JK
authors.lastname: Maurin
authors.forename: Andrzej
authors.initials: A
authors.lastname: Orzeszko
mesh_terms: D000218:Adamantane; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D054697:Cytostatic Agents; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D054697:Cytostatic Agents; D053778:Thiazolidines; D000218:Adamantane