Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone rats.
This unit describes a putative animal model for panic disorder. The basic premise is that pharmacological disruption of critical brain regions implicated in the circuitry of anxiety will lead to a condition similar to that of the human disorder. A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model.
Sajdyk
Tammy J
TJ
Indiana University Medical Center, Indianapolis, Indiana, USA.
Keim
Stanley R
SR
Thielen
Shelley R
SR
Fitz
Stephanie D
SD
Shekhar
Anantha
A
D000679:Amygdala; D000818:Animals; D001008:Anxiety Disorders / Q000139:chemically induced; D035843:Biomedical Research / Q000379:methods*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D007262:Infusions, Intravenous; D008297:Male; D009488:Neurosciences / Q000379:methods*; D016584:Panic Disorder / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D019354:Sodium Lactate / Q000008:administration & dosage*; D054832:Urocortins / Q000008:administration & dosage
D054832:Urocortins; D019354:Sodium Lactate