title: Concise synthesis of the pentasaccharide O-antigen of Escherichia coli O83:K24:H31 present in the Colinfant vaccine.
abstract: A block synthetic approach is presented for the synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O83:K24:H31 strain, present in the "Colifant" vaccine. The target pentasaccharide has been synthesized by coupling a disaccharide with a trisaccharide in excellent yield. Yields are quite satisfactory in all intermediate steps.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, 226 001, India.
authors.forename: Pintu Kumar
authors.initials: PK
authors.lastname: Mandal
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000737:chemistry* / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D022361:Escherichia coli Vaccines / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D019081:O Antigens / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology; D014614:Vaccines, Synthetic / Q000737:chemistry
chemical_list: D022361:Escherichia coli Vaccines; D019081:O Antigens; D009844:Oligosaccharides; D014614:Vaccines, Synthetic