A possible in vivo generator 103Pd/103mRh--recoil considerations.
The use of Auger emitters as potential radiopharmaceuticals is increasingly investigated. One such radionuclide of interest is (103m)Rh. This can be produced from (103)Ru or from (103)Pd in an in vivo generator. A potential problem with this concept is the recoil of the (103m)Rh out of the carrier molecule and even out of the target cell. In order to determine whether this would happen in the (103)Pd/(103m)Rh case calculations were done to prove that this does not happen. From theoretical considerations it seems that the (103)Pd/(103m)Rh in vivo generator system would be possible.
van Rooyen
Johann
J
Radiation and Reactor Theory, Necsa (South African Nuclear Energy Corporation Ltd.), P.O. Box 582, Pretoria 0001, South Africa.
Szucs
Zoltan
Z
Rijn Zeevaart
Jan
J
D003198:Computer Simulation; D004735:Energy Transfer; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry* / Q000528:radiation effects*; D011868:Radioisotopes / Q000737:chemistry* / Q000528:radiation effects*; D019275:Radiopharmaceuticals / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry* / Q000528:radiation effects*
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D010165:Palladium; D012238:Rhodium