Antiphospholipids antibodies in a 12-month-old presenting with idiopathic thrombocytopenic purpura.
A 12-month-old Caucasian female with a history of recurrent ear infections presented to the emergency room with petechiae, severe thrombocytopenia (4000/microL), and abnormally prolonged activated partial thromboplastin time. Further autoantibody investigation detected antinuclear antibodies, anti-double-stranded DNA, and antiphospholipid antibodies. Platelet count, in response to intravenous immunoglobulin infusion, increased to more than 100 x 10(3) plt/microL. At 6-month follow-up, no positive autoantibodies were detected.
Nseir
Bacel
B
Department of Internal Medicine/Pediatrics, Northeastern Ohio Universities College of Medicine/Western Reserve Care System, Youngstown, Ohio, USA. baselns@hotmail.com
Panicker
Jyoti
J
D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D007223:Infant; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology
D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors