title: Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity.
abstract: A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of alpha-nitrosoolefins with alkenes. alpha-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 microg ml(-1) for bacteria and 10-40 microg ml(-1) for fungi.
authors.affiliation: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka 570006, India. mkmraichur@yahoo.co.in
authors.forename: M K
authors.initials: MK
authors.lastname: Manjula
authors.forename: K M L
authors.initials: KM
authors.lastname: Rai
authors.forename: S L
authors.initials: SL
authors.lastname: Gaonkar
authors.forename: K A
authors.initials: KA
authors.lastname: Raveesha
authors.forename: S
authors.initials: S
authors.lastname: Satish
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D010078:Oxazines