Identifying structural noncoding RNAs using RNAz.
The functions of many noncoding RNAs and cis-acting regulatory elements of mRNAs depend on a defined RNA secondary structure. RNAz predicts such functional RNA structures on the basis of thermodynamic stability and evolutionary conservation of homologous sequences. It can be used to efficiently filter multiple alignments for noncoding RNA candidates in genomic screens.
Washietl
Stefan
S
University of Vienna, Vienna, Austria.
Hofacker
Ivo L
IL
D000465:Algorithms; D001483:Base Sequence; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D022661:RNA, Untranslated / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods; D017423:Sequence Analysis, RNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D012984:Software
D022661:RNA, Untranslated