Fatty acids and oxidative stress in psychiatric disorders.
BACKGROUND
The aim of this study was to determine whether there is published evidence for increased oxidative stress in neuropsychiatric disorders.


METHODS
A PubMed search was carried out using the MeSH search term 'oxidative stress' in conjunction with each of the DSM-IV-TR diagnostic categories of the American Psychiatric Association in order to identify potential studies.


RESULTS
There was published evidence of increased oxidative stress in the following DSM-IV-TR diagnostic categories: mental retardation; autistic disorder; Rett's disorder; attention-deficit hyperactivity disorder; delirium; dementia; amnestic disorders; alcohol-related disorders; amphetamine (or amphetamine-like)-related disorders; hallucinogen-related disorders; nicotine-related disorders; opioid-related disorders; schizophrenia and other psychotic disorders; mood disorders; anxiety disorders; sexual dysfunctions; eating disorders; and sleep disorders.


CONCLUSIONS
Most psychiatric disorders are associated with increased oxidative stress. Patients suffering from that subgroup of these psychiatric disorders in which there is increased lipid peroxidation might therefore benefit from fatty acid supplementation (preferably with the inclusion of an antioxidant-rich diet) while patients suffering from all these psychiatric disorders might benefit from a change to a whole-food plant-based diet devoid of refined carbohydrate products.
Tsaluchidu
Sofia
S
Università di Bologna, Bologna, Italy. sofia.tsl@alice.it
Cocchi
Massimo
M
Tonello
Lucio
L
Puri
Basant K
BK
D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000378:metabolism; D001523:Mental Disorders / Q000378:metabolism*; D018384:Oxidative Stress; D010743:Phospholipids / Q000378:metabolism
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids