Use of mouse models for the analysis of human disease.
The first half of this unit discusses the two main approaches to developing genetically engineered mouse models of human disease (i.e., transgenesis and gene targeting). The experimental steps for each method are discussed. Potential pitfalls, advantages, and limitations are also addressed. The second half of the unit describes two mouse models of hypertrophic cardiomyopathy, which illustrate the value of studying such models of human disease. The first half of this unit discusses the two main approaches to developing genetically engineered mouse models of human disease.
Semsarian
Christopher
C
Howard Hughes Medical Institute and Harvard Medical School, Boston, Massachusetts, USA.
D000818:Animals; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000235:genetics*; D004195:Disease Models, Animal; D018390:Gene Targeting; D005818:Genetic Engineering / Q000379:methods*; D005826:Genetics, Medical; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic