Cytotoxic phenylpropanoids from carrot.
Carrot is widely used as a foodstuff. The active components such as beta-carotene and panaxynol have been studied by many researchers. In this investigation of nonpolar active components from carrot, a new phenylpropanoid, epilaserine oxide ( 3), was isolated along with six known compounds, laserine ( 1), 2-epilaserine ( 2), panaxynol ( 4), ginsenoyne K ( 5), (8 E)-1,8-heptadecadiene-4,6-diyne-3,10-diol ( 6), and vaginatin ( 7). Their structures were deduced on the basis of spectroscopic methods. Significant cytotoxicity of 2-epilaserine against HL-60 cells was observed, which implied that phenylpropanoids were cytotoxic compounds in carrot. Laserine and 2-epilaserine in carrots from diverse locations in China were quantified by HPLC.
Yang
Ruo-Lin
RL
Department of Pharmacy, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Yan
Zhong-Hong
ZH
Lu
Yang
Y
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D052117:Benzodioxoles / Q000032:analysis / Q000494:pharmacology; D002087:Butyrates / Q000032:analysis / Q000494:pharmacology; D002681:China; D002851:Chromatography, High Pressure Liquid; D018552:Daucus carota / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D052117:Benzodioxoles; D002087:Butyrates; D010936:Plant Extracts; C530149:laserine