A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle.
BACKGROUND
Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo).


RESULTS
By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02).


CONCLUSIONS
Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.
Cheong
Hyun Sub
HS
Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul, 153-803, Korea. chhs@snp-genetics.com
Yoon
Du-Hak
DH
Park
Byung Lae
BL
Kim
Lyoung Hyo
LH
Bae
Joon Seol
JS
Namgoong
Sohg
S
Lee
Hae Won
HW
Han
Chang Soo
CS
Kim
Ji On
JO
Cheong
Il-Cheong
IC
Shin
Hyoung Doo
HD
D000818:Animals; D002154:Calpain / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D005260:Female; D005838:Genotype; D007723:Korea; D008297:Male; D008460:Meat / Q000592:standards*; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D017422:Sequence Analysis, DNA
D002154:Calpain; C484807:CAPN1 protein, Bos taurus