title: Risk of childhood cancers associated with residence in agriculturally intense areas in the United States.
abstract: BACKGROUND
  The potential for widespread exposure to agricultural pesticides through drift during application raises concerns about possible health effects to exposed children living in areas of high agricultural activity.
  
  
  OBJECTIVE
  We evaluated whether residence in a county with greater agricultural activity was associated with risk of developing cancer in children < 15 years of age.
  
  
  METHODS
  Incidence data for U.S. children 0-14 years of age diagnosed with cancer between 1995 and 2001 were provided by member registries of the North American Association of Central Cancer Registries. We determined percent cropland for each county using agricultural census data, and used the overall study distribution to classify agriculturally intense counties. We estimated odds ratios and 95% confidence intervals for all ages and 5-year age groups for total cancers and selected cancer sites using logistic regression.
  
  
  RESULTS
  Our study results showed statistically significant increased risk estimates for many types of childhood cancers associated with residence at diagnosis in counties having a moderate to high level of agricultural activity, with a remarkably consistent dose-response effect seen for counties having >or= 60% of the total county acreage devoted to farming. Risk for different cancers varied by type of crop.
  
  
  CONCLUSIONS
  Although interpretation is limited by the ecologic design, in this study we were able to evaluate rarer childhood cancers across a diverse agricultural topography. The findings of this exploratory study support a continued interest in the possible impact of long-term, low-level pesticide exposure in communities located in agriculturally intense areas.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, College Station, Texas 77843-1266, USA. scarozza@srph.tamhsc.edu
authors.forename: Susan E
authors.initials: SE
authors.lastname: Carozza
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Elgethun
authors.forename: Ryan
authors.initials: R
authors.lastname: Whitworth
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000383:Agriculture; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D016017:Odds Ratio; D010575:Pesticides / Q000633:toxicity*; D012307:Risk Factors; D017062:Small-Area Analysis; D014481:United States / Q000453:epidemiology
chemical_list: D010575:Pesticides