Does the additional application of a polylactide film (SurgiWrap) to a lightweight mesh (TiMesh) reduce adhesions after laparoscopic intraperitoneal implantation procedures? Experimental results obtained with the laparoscopic porcine model.
BACKGROUND
Intraperitoneal repair of incisional hernias using a mesh makes particular demands on the material used. In addition to good integration of the mesh on the parietal side, adhesions to the visceral peritoneum must be avoided. Large-pore, light-weight meshes induce fewer adhesions than heavy-weight polypropylene meshes. Although numerous adhesion-barrier substances for use in combination with a polypropylene mesh have been tested already, mostly in open small animal models, unequivocal benefits have been identified to date in only a few of the experiments.


METHODS
Using the laparoscopic intraperitoneal onlay mesh technique, six pigs were implanted with either a lightweight polypropylene mesh (TiMesh light) or TiMesh plus an adhesion-barrier film made of polylactide (SurgiWrap). After 3 months, the animals underwent a postmortem laparoscopy, and specimens were obtained for planimetric and histologic investigations.


RESULTS
No adhesions to intestinal structures were found in any of the animals. Adhesions between the greater omentum and the mesh did not differ significantly between the TiMesh (32%) and SurgiWrap (33.5%) groups. The shrinkage of the mesh's surface area was comparable between the two groups (18% vs. 21%). Histology showed pronounced inflammatory reaction and bridging of scar tissue between the filaments with the use of SurgiWrap versus TiMesh light without film. However, immunohistochemical investigations examining the partial volume of the inflammatory cells, the proliferation marker Ki67, and the apoptotic index at the interface of the filaments all failed to show any significant differences.


CONCLUSIONS
To avoid adhesions, it is essential that the acute and chronic inflammatory reaction to the implanted material be as small as possible. This requirement is met specifically by the lightweight polypropylene mesh TiMesh light. The additional application of a slowly absorbable adhesion-barrier film made of polylactide (SurgiWrap) does not appear to confer any further benefit.
Schug-Pass
Christine
C
Department of Surgery and Center for Minimally Invasive Surgery, Vivantes Hospital Spandau, Neue Bergstrasse 6, 13585, Berlin, Germany. christine.schug-pass@vivantes.de
Sommerer
Florian
F
Tannapfel
Andrea
A
Lippert
Hans
H
Köckerling
Ferdinand
F
D000818:Animals; D017209:Apoptosis; D015415:Biomarkers / Q000032:analysis; D006555:Hernia, Ventral / Q000601:surgery*; D007150:Immunohistochemistry; D007249:Inflammation; D019394:Ki-67 Antigen / Q000032:analysis; D010535:Laparoscopy / Q000379:methods*; D010537:Peritoneum / Q000601:surgery; D011091:Polyesters; D011126:Polypropylenes; D013526:Surgical Mesh; D013552:Swine; D000267:Tissue Adhesions / Q000517:prevention & control*
D015415:Biomarkers; D019394:Ki-67 Antigen; D011091:Polyesters; D011126:Polypropylenes; C033616:poly(lactide)