title: Epstein-Barr virus-associated central nervous system lymphoproliferative disease in a patient with acquired immunodeficiency syndrome responsive to highly active antiretroviral therapy.
abstract: A 20-year-old man with acquired immunodeficiency syndrome (AIDS) and central nervous system (CNS) lymphoproliferative disease experienced improvement with highly active antiretroviral therapy (HAART) without radiation therapy. Our experience highlights the importance of biopsy in evaluating multifocal radiographic CNS lesions and the central role of HAART in treating AIDS-related CNS disease.
authors.affiliation: Division of General Pediatrics and Adolescent Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. dkuo5@jhmi.edu
authors.forename: Dennis Z
authors.initials: DZ
authors.lastname: Kuo
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Milstone
authors.forename: Stephanie O
authors.initials: SO
authors.lastname: Omokaro
authors.forename: Alan D
authors.initials: AD
authors.lastname: Friedman
authors.forename: Zarir E
authors.initials: ZE
authors.lastname: Karanjawala
authors.forename: Michael
authors.initials: M
authors.lastname: Borowitz
authors.forename: Mary L
authors.initials: ML
authors.lastname: Joyner
authors.forename: Neal A
authors.initials: NA
authors.lastname: Halsey
authors.forename: Erica M
authors.initials: EM
authors.lastname: Sibinga
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000188:drug therapy* / Q000821:virology; D008297:Male; D016896:Treatment Outcome