title: Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696).
abstract: BACKGROUND
  Emergency abdominal surgery carries a high risk of postoperative morbidity and mortality. Goal directed therapy has been advocated to improve outcome in high-risk surgery. The aim of the present pilot study was to examine the effect of goal directed therapy using fluid alone on postoperative renal function and organ failure score in patients undergoing emergency abdominal surgery.
  
  
  METHODS
  This prospective randomised pilot study included patients over the age of 50 undergoing emergency abdominal surgery. In the intervention group pulse pressure variation measurements were used to guide fluid boluses of 6% Hydroxyethylstarch 130/0.4. The control group received standard care. Serum urea, creatinine and cystatin C levels were measured prior to and at the end of surgery and postoperatively on day 1, day 3 and day 5.
  
  
  RESULTS
  Thirty patients were recruited. One patient died prior to surgery and was excluded from the analysis. The intervention group received a median of 750 ml of hydroxyethylstarch. The peak values of postoperative urea were 6.9 (2.7-31.8) vs. 6.4 (3.5-11.5)mmol/l (p=0.425), creatinine 100 (60-300) vs. 85 (65-150) micromol/l (p=0.085) and cystatin C 1.09 (0.66-4.94) vs. 1.01 (0.33-2.29)mg/dl (p=0.352) in the control and intervention group, respectively.
  
  
  CONCLUSIONS
  In the present pilot study replacing the identified fluid deficit was not associated with a change in renal function. These results do not preclude that goal directed therapy using fluid alone may have an effect on renal function but they would suggest that the effect size of fluid optimisation alone on renal function is small.
authors.affiliation: Department of Anaesthesia, Gartnavel General Hospital, Glasgow G12 0YN, UK. jharten@doctors.org.uk
authors.forename: J
authors.initials: J
authors.lastname: Harten
authors.forename: J E M
authors.initials: JE
authors.lastname: Crozier
authors.forename: B
authors.initials: B
authors.lastname: McCreath
authors.forename: A
authors.initials: A
authors.lastname: Hay
authors.forename: D C
authors.initials: DC
authors.lastname: McMillan
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
authors.forename: J
authors.initials: J
authors.lastname: Kinsella
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D000368:Aged; D001794:Blood Pressure; D002302:Cardiac Output; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D013505:Digestive System Surgical Procedures; D004630:Emergencies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007430:Intraoperative Care; D007668:Kidney / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D010952:Plasma Substitutes / Q000627:therapeutic use*; D014508:Urea / Q000097:blood
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; C485123:HES 130-0.4; D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D014508:Urea; D003404:Creatinine; D010100:Oxygen