Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.
A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test.
Sheng
Rong
R
ZJU-ENS joint laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences, Zijingang Campus, Zhejiang University Hangzhou 310058, People's Republic of China.
Xu
Yu
Y
Hu
Chunqi
C
Zhang
Jing
J
Lin
Xiao
X
Li
Jingya
J
Yang
Bo
B
He
Qiaojun
Q
Hu
Yongzhou
Y
D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D008568:Memory / Q000187:drug effects; D051379:Mice; D010146:Pain / Q000378:metabolism; D013329:Structure-Activity Relationship
D001572:Benzofurans; D002800:Cholinesterase Inhibitors; D007189:Indans; C486837:aurone; C013352:indacrinone