title: Clinical assessment of nasal decongestion test by VAS in adolescents.
abstract: Nasal airflow, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). The decongestion test evaluates whether the application of an intranasal vasoconstrictor drug increases nasal airflow. The aim of this study was to verify the suitability of the use of the visual analogue scales (VAS) as a surrogate for rhinomanometry in the decongestion test assessment in adolescents with atopic rhinitis. Forty adolescents [16 males and 24 females, mean age 15 (s.d. 2) yr] with AR were studied. Nasal symptoms, VAS, rhinomanometry, and nasal decongestion test were assessed in all patients. A significant association was observed between VAS and nasal airflow after performing the decongestion test (Spearman's r is -51.7%, p < 0.001). The associated sensitivity and specificity were 84.8 (95% confidence interval, CI 68.1-94.8) and 85.7 (95% CI 42.2-97.6), respectively. The corresponding area under the receiver operating characteristic (ROC) curve of 0.83 (95% CI 0.67-0.93) indicated a good discriminating ability for the decongestion measured on the VAS scale. In conclusion, the use of VAS appears as clinically relevant, in that it allows, with a fair reliability, to perform the decongestion test in the absence of rhinomanometry.
authors.affiliation: Dipartimento di Scienze Pediatriche, Università di Pavia - Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. gl.marseglia@smatteo.pv.it
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
authors.forename: Ignazio
authors.initials: I
authors.lastname: Cirillo
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Davide
authors.initials: D
authors.lastname: Caimmi
authors.forename: Silvia
authors.initials: S
authors.lastname: Caimmi
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Castellazzi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D008297:Male; D014663:Nasal Decongestants / Q000008:administration & dosage; D015508:Nasal Obstruction / Q000175:diagnosis* / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods*; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D025363:Rhinomanometry / Q000379:methods; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D014663:Nasal Decongestants