title: Optic nerve and chiasm enlargement in a case of infantile Krabbe disease: quantitative comparison with 26 age-matched controls.
abstract: Hypertrophy of the optic nerves and optic chiasm is described in a 5-month-old boy with infantile Krabbe disease. Optic nerve and optic chiasm hypertrophy is a rarely described feature of Krabbe disease. The areas of the prechiasmatic optic nerves and optic chiasm were measured and compared with those of 26 age-matched controls. The areas of the prechiasmatic optic nerves and optic chiasm were 132% and 53% greater than normal, respectively.
authors.affiliation: Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
authors.forename: Bhairav
authors.initials: B
authors.lastname: Patel
authors.forename: Barjor
authors.initials: B
authors.lastname: Gimi
authors.forename: Behroze
authors.initials: B
authors.lastname: Vachha
authors.forename: Satish
authors.initials: S
authors.lastname: Agadi
authors.forename: Korgun
authors.initials: K
authors.lastname: Koral
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000150:complications*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009897:Optic Chiasm / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D011859:Radiography