title: Treatment of advanced or recurrent colorectal cancer with irinotecan in Japan and elsewhere.
abstract: BACKGROUND
  Dramatic prolongation of the survival of patients with advanced or recurrent colorectal cancer has been achieved by multi-drug chemotherapy using agents such as continuous 5-fluorouracil and leucovorin, irinotecan (CPT-11), L-OHP, bevacizumab and cetuximab.
  
  
  OBJECTIVE
  To explain the background of CPT-11 and to discuss its role in the treatment of advanced or recurrent colorectal cancer in Japan and elsewhere together with the authors' own experience.
authors.affiliation: Kitasato University East Hospital, Department of Surgery, 2-1-1, Asamizodai, Sagamihara, Kanagawa, 228-8520, Japan. takeo@kitasato-u.ac.jp
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hatate
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamanashi
authors.forename: Heita
authors.initials: H
authors.lastname: Ozawa
authors.forename: Wataru
authors.initials: W
authors.lastname: Onosato
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ihara
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D000077146:Irinotecan; D007564:Japan; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D015996:Survival Rate; D059004:Topoisomerase I Inhibitors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D059004:Topoisomerase I Inhibitors; D000077146:Irinotecan; D002166:Camptothecin