Effects of heat on camel platelet structure and function-a comparative study with humans.
Camels and many other desert animals are uniquely adapted to conserve water and other fluids in order to survive intense heat for long periods. Earlier studies have suggested that human platelets may be the trigger for the coagulopathy involved in heat prostration and stroke. The present study has compared the resistance of camel and human platelets to heat in order to see if they might help to protect camels from the effects of high body temperature for prolonged periods. The findings demonstrate that camel platelets are significantly less sensitive to heat than human platelets. Temperatures (43 degrees C-45 degrees C) that cause human cells to undergo marked structural alterations and lose their ability to spread and aggregate have no effect on camel platelets. Even higher temperatures (50 degrees C) that destroy human platelets have minor effects on camel cells and do not seriously compromise their function. Temperatures of 55 degrees C do destroy camel platelets and their functional capability. The resistance of camel platelets to heat may help protect camels from the effects of extreme body temperature and dehydration, which are everyday conditions in the desert.
Al Ghumlas
Abeer K
AK
Physiology Department, The Coagulation Laboratory, College of Medicine, King Saud University, Riyadh.
Abdel Gader
Abdel Galil M
AG
Hussein
Mansour F
MF
Al Haidary
Ahmed
A
White
James G
JG
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure*; D002162:Camelus / Q000097:blood; D006487:Hemostasis; D006358:Hot Temperature; D006801:Humans; D046529:Microscopy, Electron, Transmission; D010974:Platelet Aggregation / Q000502:physiology; D013997:Time Factors