title: Intradural extramedullary tuberculoma of the thoracic spine: paradoxical response to antituberculous therapy.
abstract: Intradural extramedullary tuberculoma of the spinal cord (IETSC) is a rare complication of tuberculosis, which can occur as a paradoxical response to antituberculous therapy. A 46-year-old woman with tuberculosis meningitis developed an acute sensory disturbance and paraplegia eight weeks after the antituberculous treatment was started. MRI revealed a cystic lesion at the Th 2 and 3 vertebrae levels, and continuous dural thickening. Laminectomy was performed; soft granulomas were unexpectedly observed inside the dura matter. After the operation, the patient experienced progressive improvement in motor strength. IETSC should be known as rare but possible complication of tuberculous meningitis.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba. takahashi.h@graduate.chiba-u.jp
authors.forename: Hirokatsu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ito
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kojima
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tanno
authors.forename: Takamichi
authors.initials: T
authors.lastname: Hattori
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004388:Dura Mater / Q000473:pathology; D005260:Female; D006801:Humans; D007796:Laminectomy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D013904:Thoracic Vertebrae / Q000473:pathology; D014375:Tuberculoma / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000995:Antitubercular Agents