title: Intrahepatic splenosis with severe iron deposition presenting with atypical magnetic resonance images.
abstract: An intrahepatic mass was incidentally found in a 41-year-old man with a history of a traffic accident injury which resulted in removal of a ruptured spleen. Hepatic splenosis was considered in the differential diagnosis but magnetic resonance imaging showed hypointensity on T2-weighted images, atypical for normal spleen. Histologically, the mass showed sinusoidal structures and lymphoid follicular aggregates. Immunohistochemical study showed that the phenotype of the vascular lining cells was CD8-positive, CD31-positive, and CD34 negative, the pattern diagnostic for ectopic spleen. In addition, severe iron deposition was histologically demonstrated, which was considered as the cause of the hypointense T2-weighted images.
authors.affiliation: Department of Internal Medicine, Saiseikai Kyoto Hospital, Nagaoka-kyo. tomnaka@silver.ocn.ne.jp
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Mio
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Makiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wakae
authors.forename: Kinya
authors.initials: K
authors.lastname: Fujita
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Shiomi
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohishi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakashima
authors.forename: Eiichi
authors.initials: E
authors.lastname: Konishi
mesh_terms: D000328:Adult; D001706:Biopsy; D002828:Choristoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013154:Spleen; D017890:Splenosis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*
chemical_list: D007501:Iron