title: Childhood scrub typhus in eastern Taiwan: ten-year experience from a medical center.
abstract: BACKGROUND
  Scrub typhus, a potentially fatal rickettsial infection, is endemic in western Pacific Rims including Taiwan. Most reports have been concerned about mainly adult patients, whereas serologic surveys suggested that as many as one-half of cases of scrub typhus might be in children.
  
  
  METHODS
  We conducted a retrospective study of childhood scrub typhus in our hospital from January 1997 to December 2006. Scrub typhus was diagnosed on the basis of serology tests or polymerase chain reaction (PCR) examination in fifteen children.
  
  
  RESULTS
  Fever and chigger bite history were presented in all 15 cases, and eschar lesion was identified in 12 patients (80%). Nine (60%) patients had headache and six (40%) complained of abdominal pain. Three patients (20%) had meningoencephalitis, and two (13%) hemophagocytic syndrome were confirmed by bone marrow biopsy. One patient died of progressive acute respiratory distress syndrome (ARDS) and pulmonary hemorrhage. Myocarditis was revealed in autopsy. All surviving patient responded well to antibiotic therapy, and the average duration to defervescence after treatment was 1.8 days.
  
  
  CONCLUSIONS
  We conclude that scrub typhus should be taken into consideration among patients of acute systemic febrile illness, especially those with suspected exposure history and typical skin lesion. Although most patients responded well to treatment, severe complications such as meningoencephalitis, interstitial pneumonia, acute respiratory distress syndrome, hemophagocytic syndrome, and myocarditis might lead to morbidity and mortality.
authors.affiliation: Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Shang-Hsien
authors.initials: SH
authors.lastname: Yang
authors.forename: Yu-Huai
authors.initials: YH
authors.lastname: Ho
authors.forename: Chia-Hsiang
authors.initials: CH
authors.lastname: Chu
authors.forename: Shao-Yin
authors.initials: SY
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012612:Scrub Typhus / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy