Recent advances in RNA structure determination by NMR.
Despite recent advances in the solution of NMR structures of RNA and RNA-ligand complexes, the rate limiting step remains the gathering of a large number of NOE and torsion restraints. Additional sources of information for structure determination of larger RNA molecules have recently become available, and it is possible to supplement NOE and J-coupling data with the measurement of dipolar couplings and cross-correlated relaxation rates in high-resolution NMR spectroscopy.
Hennig
M
M
The Scripps Research Institute, La Jolla, California, USA.
Williamson
J R
JR
Brodsky
A S
AS
Battiste
J L
JL
D001483:Base Sequence; D006860:Hydrogen Bonding; D007553:Isotope Labeling; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics
D012313:RNA