title: A geometric flow-based approach for diffusion tensor image segmentation.
abstract: Diffusion tensor magnetic resonance imaging (DT-MRI, shortened as DTI) produces, from a set of diffusion-weighted magnetic resonance images, tensor-valued images where each voxel is assigned a 3x3 symmetric, positive-definite matrix. This tensor is simply the covariance matrix of a local Gaussian process with zero mean, modelling the average motion of water molecules. We propose a three-dimensional geometric flow-based model to segment the main core of cerebral white matter fibre tracts from DTI. The segmentation is carried out with a front propagation algorithm. The front is a three-dimensional surface that evolves along its normal direction with speed that is proportional to a linear combination of two measures: a similarity measure and a consistency measure. The similarity measure computes the similarity of the diffusion tensors at a voxel and its neighbouring voxels along the normal to the front; the consistency measure is able to speed up the propagation at locations where the evolving front is more consistent with the diffusion tensor field, to remove noise effect to some extent, and thus to improve results. We validate the proposed model and compare it with some other methods using synthetic and human brain DTI data; experimental results indicate that the proposed model improves the accuracy and efficiency in segmentation.
authors.affiliation: Department of Mathematics, University of Alabama, Box 870350, Tuscaloosa, AL 35487, USA. wguo@as.ua.edu
authors.forename: Weihong
authors.initials: W
authors.lastname: Guo
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Chen
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Zeng
mesh_terms: D000465:Algorithms; D001699:Biometry; D001921:Brain / Q000033:anatomy & histology; D003337:Corpus Callosum / Q000033:anatomy & histology; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data; D008953:Models, Anatomic; D015233:Models, Statistical