Predictors of smokeless tobacco abstinence.
OBJECTIVE
To investigate predictors of tobacco abstinence among smokeless tobacco (ST) users.


METHODS
Logistic regression analyses assessed characteristics associated with tobacco abstinence among ST users receiving bupropion SR.


RESULTS
Older age was associated with increased tobacco abstinence in both placebo and bupropion SR groups at end of treatment and one year. Abstinence was lower at one year for subjects with a history of major depression. At end-of-treatment, a 2-way interaction was detected suggesting bupropion SR may be efficacious for subjects with other household tobacco users.


CONCLUSIONS
Younger ST users and those with a history of depression are less likely to quit ST use.
Ebbert
Jon O
JO
Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. ebbert.jon@mayo.edu
Glover
Elbert D
ED
Shinozaki
Eri
E
Schroeder
Darrell R
DR
Dale
Lowell C
LC
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D016642:Bupropion / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000517:prevention & control*; D020340:Tobacco Use Cessation / Q000706:statistics & numerical data*; D014030:Tobacco, Smokeless
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion