title: Tinnitus and brain MRI findings in Japanese elderly.
abstract: CONCLUSIONS
  There is evidence of an inverse association between cerebral infarction and tinnitus in this study. The effects of cerebral infarction on tinnitus could be explained by a neurophysiological model of tinnitus.
  
  
  OBJECTIVE
  We examined the relationship between tinnitus and brain MRI findings including cerebral infarction, brain atrophy, ventricular dilatation, and white matter lesions.
  
  
  METHODS
  This was a cross-sectional population-based study of 2193 subjects aged 41-82 years living in Aichi prefecture, Japan. Detailed questionnaires, pure tone audiometry, and brain MRI were performed.
  
  
  RESULTS
  After adjusting for potential confounders in a multiple logistic analysis, cerebral infarction was inversely associated with tinnitus (odds ratio (OR)=0.649, 95% confidence interval (CI)=0.477-0.884). Cerebral infarctions of the basal ganglia (OR=0.542), thalamus (OR=0.441), and pons (OR=0.319) were especially associated with tinnitus. Brain atrophy, ventricular dilatation, and white matter lesions had no significant effects on the prevalence of tinnitus.
authors.affiliation: Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. saiko@ncgg.go.jp
authors.forename: Saiko
authors.initials: S
authors.lastname: Sugiura
authors.forename: Yasue
authors.initials: Y
authors.lastname: Uchida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Fujiko
authors.initials: F
authors.lastname: Ando
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology; D020144:Basal Ganglia Cerebrovascular Disease; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis*; D020526:Brain Stem Infarctions / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis; D002552:Cerebral Ventricles / Q000473:pathology; D003430:Cross-Sectional Studies; D003711:Demyelinating Diseases / Q000175:diagnosis; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011149:Pons / Q000473:pathology; D013786:Thalamic Diseases; D014012:Tinnitus / Q000209:etiology*