title: Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia.
abstract: Three triterpenoids, 16beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (1), 3beta,21beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (2) and 16beta-hydroxylupane-1,20(29)-dien-3-one (3), along with eleven known triterpenes were isolated from stems of Stauntonia obovatifoliola Hayata subsp. intermedia (Y.C. Wu) T. Chen. Their structures were determined by analysis of HR-EI/FAB-MS and 1D and 2D NMR spectroscopic data and comparison with those in the literature. Ten of the compounds showed inhibitory activity against HIV-1 protease.
authors.affiliation: Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Chao-mei
authors.initials: CM
authors.lastname: Ma
authors.forename: De-yuan
authors.initials: DY
authors.lastname: Chen
authors.forename: Masao
authors.initials: M
authors.lastname: Hattori
mesh_terms: D029624:Ferns / Q000737:chemistry*; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D017320:HIV Protease Inhibitors; D014315:Triterpenes