title: Evidence for immunisation failure in vaccinated adult dogs infected with canine parvovirus type 2c.
abstract: An outbreak of canine parvovirus type 2c (CPV-2c) infection in vaccinated adult dogs is reported. The disease occurred in a breeding kennel in Italy and affected 11 dogs aged between 6 months and 2.5 years, that had been repeatedly administered vaccines containing a type 2 (old type) CPV strain. CPV infection was demonstrated in all diseased dogs by an immunochromatographic test. A CPV strain was isolated from the intestinal content of a 20-month-old pregnant Bernese mountain bitch that underwent a fatal outcome. The strain was characterised as CPV-2c by means of real-time PCR assays using minor groove binder probes. The present report provides further concerns about the real efficacy of type 2-based vaccines against the antigenic variants of CPV and stresses the need for developing new vaccines prepared with the variants currently circulating in the dog population.
authors.affiliation: Department of Animal Health and Well-being, Faculty of Veterinary Medicine of Bari, Valenzano, Bari, Italy. n.decaro@veterinaria.uniba.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Costantina
authors.initials: C
authors.lastname: Desario
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Viviana
authors.initials: V
authors.lastname: Mari
authors.forename: Antonio
authors.initials: A
authors.lastname: Lavazza
authors.forename: Manuela
authors.initials: M
authors.lastname: Nardi
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002460:Cell Line; D004196:Disease Outbreaks; D004283:Dog Diseases / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D004285:Dogs; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D007114:Immunization / Q000662:veterinary; D008297:Male; D010322:Parvoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary / Q000821:virology; D017211:Treatment Failure; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines