title: Sepsis associated encephalopathy in an infant with biliary atresia.
abstract: We describe a girl with sepsis-associated encephalopathy complicating biliary atresia. At 4 months of age, decreased consciousness and repetitive seizures of the left upper and lower extremities occurred in association with fever. Pseudomonas aeruginosa was cultured from blood, while bacterial culture was negative and cell counts were normal in cerebrospinal fluid. The interleukin-6 level in the cerebrospinal fluid was markedly elevated. MRI revealed unilateral subcortical white matter lesions in the right hemisphere. She was diagnosed as having sepsis-associated encephalopathy and was treated with dexamethasone and midazolam. She achieved normal psychomotor development until the last follow-up at 19 months of age, whereas mild atrophic changes were observed in the right hemisphere.
authors.affiliation: Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. s-abe@noi.bb4u.ne.jp
authors.forename: Shinpei
authors.initials: S
authors.lastname: Abe
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
authors.forename: Tohru
authors.initials: T
authors.lastname: Fujii
authors.forename: Tomonosuke
authors.initials: T
authors.lastname: Someya
authors.forename: Rieko
authors.initials: R
authors.lastname: Tadokoro
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Arai
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamashiro
mesh_terms: D001656:Biliary Atresia / Q000150:complications* / Q000473:pathology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D018805:Sepsis / Q000150:complications* / Q000209:etiology* / Q000473:pathology