Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons.
In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression.
Tomchik
Seth M
SM
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Davis
Ronald L
RL
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism*; D029721:Drosophila Proteins / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D029721:Drosophila Proteins; D009479:Neuropeptides; C113883:pdf protein, Drosophila; D000242:Cyclic AMP