Biotransformation of (+/-)-2-methylcyclohexanone by fungi.
The biotransformation of 2-methylcyclohexanone (1) using 16 fungal strains and some mushroom cultures was investigated. Fusarium sp. was one of the effective biocatalysts for oxidoreduction of 2-methylcyclohexanone (1). cis-2-Methylcyclohexanol (2a) was isomerized to trans-2-methylcyclohexanol (2b) by Fusarium sp. In addition, the corresponding lactones 3 was obtained by Baeyer-Villiger oxidation using Fusarium sp. AP-2 (46%, 94% ee).
Kawamoto
Mai
M
Department of Chemistry, Rikkyo (St. Paul's) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan.
Utsukihara
Takamitsu
T
Abe
Chika
C
Sato
Michiko
M
Saito
Michihiko
M
Koshimura
Masahiro
M
Kato
Nakahide
N
Horiuchi
C Akira
CA
D001711:Biotransformation; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry / Q000378:metabolism*; D005670:Fusarium / Q000378:metabolism*; D010084:Oxidation-Reduction; D013997:Time Factors
D003512:Cyclohexanones; C532535:2-methylcyclohexanone