title: A case of granuloma in the occipital lobe of a patient with Wegener's granulomatosis.
abstract: We report a case of Wegener's granulomatosis (WG) with central nervous system (CNS) involvement in a woman who complained of bilateral visual disturbance. The intracranial necrotizing granulomatous lesion was confirmed by MR imaging and brain biopsy. After high-dose oral corticosteroid treatment, not only clinical manifestations but also laboratory tests improved. Moreover, the CNS lesion completely regressed. This suggests that high-dose corticosteroid alone might be effective in treating WG with CNS involvement.
authors.affiliation: Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. naoazuuh@hyo-med.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Azuma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Katada
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Nishimura
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yamada
authors.forename: Ryunosuke
authors.initials: R
authors.lastname: Uranishi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakatsuka
authors.forename: Makoto
authors.initials: M
authors.lastname: Dehara
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Harada
authors.forename: Takao
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Saeki
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D020293:Vasculitis, Central Nervous System / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone