title: Association of fibrinogen and fibrinogen gene beta148 and beta854 polymorphisms with coronary heart disease.
abstract: BACKGROUND
  The aim of this study was to observe the association between fibrinogen C148T, G854A polymorphisms and plasma fibrinogen levels in a large cohort of Chinese patients with coronary heart disease (CHD).
  
  
  METHODS
  Fibrinogen gene beta148/beta854 polymorphisms were screened and plasma fibrinogen levels and lipids were measured in patients with angiographically confirmed CHD (n = 836) and in controls without CHD (n = 418).
  
  
  RESULTS
  Age, sex, smoking, hypertension, diabetes mellitus, blood lipids and fibrinogen levels were related to CHD (all p < 0. 05) while the frequencies of fibrinogen beta148 and beta854 alleles, gene and genotypes between the two groups were similar (all p > 0.05).
  
  
  CONCLUSIONS
  This study demonstrates that the plasma fibrinogen level, but not fibrinogen beta148 and beta854 genotypes, was associated with CHD in the Chinese population.
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
authors.forename: Ai-jun
authors.initials: AJ
authors.lastname: Sun
authors.forename: Hui-li
authors.initials: HL
authors.lastname: Ma
authors.forename: Xue-ying
authors.initials: XY
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Ye-ming
authors.initials: YM
authors.lastname: Fang
authors.forename: Yong-li
authors.initials: YL
authors.lastname: Ma
authors.forename: Ke-qiang
authors.initials: KQ
authors.lastname: Wang
authors.forename: Yun-zeng
authors.initials: YZ
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jun-bo
authors.initials: JB
authors.lastname: Ge
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: D005340:Fibrinogen