[Genetic polymorphism for genes of alcohol dependence].
Alcohol dependence is a complex disorder which is influenced by physiological, psychological, environmental factors, individual inheritance and so on. Several candidate genes associated with alcohol dependence risk have been identified. The review focuses on several related genes that control alcohol metabolism such as alcohol dehydrogenase, aldehyde dehydrogenase, cytochrome P450 2E1 and regulate neurotransmission such as catechol-O-methyltransferase, dopamine receptors D2 and D4, and mu opioid receptor.
He
Gen-Feng
GF
Department of Forensic Medicine, Kunming Medical College, Kunming 650031, China. hgf613817@163.com
Zhong
Shu-Rong
SR
Jing
Qiang
Q
D000426:Alcohol Dehydrogenase / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics
D017448:Receptors, Dopamine D2; D000426:Alcohol Dehydrogenase; D019392:Cytochrome P-450 CYP2E1; D000444:Aldehyde Dehydrogenase; D002394:Catechol O-Methyltransferase