title: The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes.
abstract: We determined the IL-6 -174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 -174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Saumoy
authors.forename: Miguel
authors.initials: M
authors.lastname: López-Dupla
authors.forename: Sergi
authors.initials: S
authors.lastname: Veloso
authors.forename: Carlos
authors.initials: C
authors.lastname: Alonso-Villaverde
authors.forename: Pere
authors.initials: P
authors.lastname: Domingo
authors.forename: Montserrat
authors.initials: M
authors.lastname: Broch
authors.forename: Merce
authors.initials: M
authors.lastname: Miranda
authors.forename: Blai
authors.initials: B
authors.lastname: Coll
authors.forename: Amadeu
authors.initials: A
authors.lastname: Saurí
authors.forename: Joan
authors.initials: J
authors.lastname: Vendrell
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Richart
authors.forename: Francesc
authors.initials: F
authors.lastname: Vidal
mesh_terms: D000328:Adult; D000483:Alleles; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000032:analysis; D050151:Subcutaneous Fat / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; D015850:Interleukin-6; D012333:RNA, Messenger