Challenges to evidence-based prescribing in clinical practice.
Although there appears to be widespread support of evidence-based medicine as a basis for rational prescribing, the challenges to it are significant and often justified. A multitude of factors other than evidence drive clinical decision-making, including patient preferences and social circumstances, presence of disease-drug and drug-drug interactions, clinical experience, competing demands from more pressing clinical conditions, marketing and promotional activity, and system-level drug policies.
Mamdani
Muhammad
M
Applied Health Research Centre, Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
Ching
Andrew
A
Golden
Brian
B
Melo
Magda
M
Menzefricke
Ulrich
U
D011307:Drug Prescriptions / Q000592:standards*; D019317:Evidence-Based Medicine / Q000379:methods / Q000592:standards* / Q000639:trends; D005194:Family Practice / Q000379:methods / Q000592:standards* / Q000639:trends; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards