Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States.
The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 bla(KPC)-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids.
Endimiani
Andrea
A
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA.
Carias
Lenore L
LL
Hujer
Andrea M
AM
Bethel
Christopher R
CR
Hujer
Kristine M
KM
Perez
Federico
F
Hutton
Rebecca A
RA
Fox
William R
WR
Hall
Geraldine S
GS
Jacobs
Michael R
MR
Paterson
David L
DL
Rice
Louis B
LB
Jenkins
Stephen G
SG
Tenover
Fred C
FC
Bonomo
Robert A
RA
D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D010957:Plasmids / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology; D014481:United States / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D017931:DNA Primers; D004269:DNA, Bacterial; D015363:Quinolones; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae