title: Both the hippocampus and striatum are involved in consolidation of motor sequence memory.
abstract: Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.
authors.affiliation: Cyclotron Research Centre, University of Liège, B-4000 Liège, Belgium.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Albouy
authors.forename: Virginie
authors.initials: V
authors.lastname: Sterpenich
authors.forename: Evelyne
authors.initials: E
authors.lastname: Balteau
authors.forename: Gilles
authors.initials: G
authors.lastname: Vandewalle
authors.forename: Martin
authors.initials: M
authors.lastname: Desseilles
authors.forename: Thanh
authors.initials: T
authors.lastname: Dang-Vu
authors.forename: Annabelle
authors.initials: A
authors.lastname: Darsaud
authors.forename: Perrine
authors.initials: P
authors.lastname: Ruby
authors.forename: Pierre-Hervé
authors.initials: PH
authors.lastname: Luppi
authors.forename: Christian
authors.initials: C
authors.lastname: Degueldre
authors.forename: Philippe
authors.initials: P
authors.lastname: Peigneux
authors.forename: André
authors.initials: A
authors.lastname: Luxen
authors.forename: Pierre
authors.initials: P
authors.lastname: Maquet
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D003342:Corpus Striatum / Q000098:blood supply / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology* / Q000528:radiation effects*; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology; D012691:Serial Learning / Q000502:physiology*; D013647:Task Performance and Analysis
chemical_list: D010100:Oxygen