Association between fatty acid binding protein 3 gene variants and essential hypertension in humans.
BACKGROUND
We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans.


METHODS
We evaluated two single-nucleotide polymorphisms (SNPs) (rs2279885 and rs2271072) in 758 patients with EH and 726 controls. Polymorphism-related genotypes were determined using TaqMan assays, while haplotypes were estimated from the genotype data.


RESULTS
The frequencies of occurrence of the G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects (P = 0.0339, P = 0.0209, respectively). However, the genotype distributions did not exhibit any significant differences.


CONCLUSIONS
We found an association between FABP3 gene polymorphisms and EH in a Japanese population, thereby suggesting that FABP3 is a susceptibility locus for EH.
Ueno
Takahiro
T
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. tueno@med.nihon-u.ac.jp
Soma
Masayoshi
M
Tabara
Yasuharu
Y
Tokunaga
Katsushi
K
Tahira
Kzunobu
K
Fukuda
Noboru
N
Matsumoto
Koichi
K
Nakayama
Tomohiro
T
Katsuya
Tomohiro
T
Ogihara
Toshio
T
Makita
Yoshio
Y
Hata
Akira
A
Yamada
Michiko
M
Takahashi
Norio
N
Hirawa
Nobuhito
N
Umemura
Satoshi
S
Miki
Tetsuro
T
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004198:Disease Susceptibility; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins