Antiarrhythmic effects of statins in heart failure.
In vitro heart failure models indicate that statins may be antiarrhythmic, but the mechanisms by which statins are antiarrhythmic are not completely understood. Several retrospective and post hoc analysis studies also indicate that statins can be antiarrhythmic in heart failure populations, but this was not confirmed by a recent large prospective randomized controlled clinical trial. Ongoing and future clinical trials will likely resolve the discrepancies between studies and further the understanding of how pleiotropic properties of statins can be antiarrhythmic in patients who have heart failure.
Sandesara
Chirag M
CM
University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Roodneshin
Hamid
H
Sbaity
Salam
S
Olshansky
Brian
B
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology* / Q000628:therapy; D001808:Blood Vessels / Q000187:drug effects; D002986:Clinical Trials as Topic; D017147:Defibrillators, Implantable; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D007473:Ion Channels / Q000187:drug effects
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007473:Ion Channels