title: In vitro models of human T cell anergy.
abstract: T cell anergy (acquired unresponsiveness) is an important mechanism for tolerance of self antigens. Human helper T cell clones rendered anergic in vitro are valuable tools for studying the molecular mechanisms of T cell tolerance. This unit outlines the induction and assessment of anergy in human CD4+ helper T cell clones that are reactive against MHC class II alloantigens.
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Leonard J
authors.initials: LJ
authors.lastname: Appleman
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Boussiotis
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D017635:Clonal Anergy; D002999:Clone Cells; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007519:Isoantigens; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D000949:Histocompatibility Antigens Class II; D007519:Isoantigens