title: Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.
abstract: Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.
authors.affiliation: University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Cindy J
authors.initials: CJ
authors.lastname: Choy
authors.forename: Dan P
authors.initials: DP
authors.lastname: Drontle
authors.forename: Carston R
authors.initials: CR
authors.lastname: Wagner
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates / Q000737:chemistry*; D010084:Oxidation-Reduction; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000596:Amino Acids; D004952:Esters; D063065:Organophosphonates; D010756:Phosphoric Acids; C011067:phosphoramidic acid