A new generation of high flex life polyurethane urea for polymer heart valve--studies on in vivo biocompatibility and biodurability.
Development of new generation high flex life polyurethane urea (HFL18-PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long-term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether-free physically cross-linked and low elastic modulus (6.841 +/- 0.27 MPa) polyurethane urea having in vivo biostability, in vivo biocompatibility and high flex-life (721 +/- 30 million cycles) that can satisfy the requirements for the fabrication of tri-leaflet heart valve.
Thomas
Vinoy
V
Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695 012, India.
Jayabalan
Muthu
M
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002113:Calcification, Physiologic; D002460:Cell Line; D004548:Elasticity; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D006350:Heart Valve Prosthesis; D006801:Humans; D008422:Materials Testing; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011140:Polyurethanes / Q000737:chemistry / Q000378:metabolism; D011475:Prosthesis Failure; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013718:Tensile Strength
D001672:Biocompatible Materials; D011140:Polyurethanes; C044690:polyetherurethane urea