Poly(ether ester amide) microspheres for protein delivery: influence of copolymer composition on technological and biological properties.
The production of PEEA microspheres with potential as carriers for protein oral delivery is described. PEEAs with different hydrophilicity were synthesized and characterized. Experiments showed that an increase in copolymer hydrophilicity gave particles less prone to cell interaction. BSA release profiles from PEEA microspheres demonstrated that an increase in polymer hydrophilicity was useful in limiting protein burst and modulating drug delivery rate by increasing PEEA degradability. These results show that fine-tuning of the hydrophilic/hydrophobic properties of PCL is essential for the formulation protein-loaded microspheres with specific properties.
Ostacolo
Luisanna
L
Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Russo
Paola
P
De Rosa
Giuseppe
G
La Rotonda
Maria Immacolata
MI
Maglio
Giovanni
G
Nese
Giuseppe
G
Spagnuolo
Gianrico
G
Rengo
Sandro
S
Oliva
Adriana
A
Quaglia
Fabiana
F
D000818:Animals; D018938:Caco-2 Cells; D002417:Cattle; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008863:Microspheres; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000494:pharmacology
D004337:Drug Carriers; D009757:Nylons; D011091:Polyesters; D012710:Serum Albumin, Bovine