[Study on the formulation and process of Da Chuan Xiong Fang pellet by extrusion-spheronization].
OBJECTIVE
To study on the formulation and process of Da Chuan Xiong Fang pellet by extrusion-spheronization.


METHODS
Based on the physical characters of active parts, the fast-release pellets of Chuan Xiong and Tian Ma were prepared separately by extrusion-spheronization. The formulation and process were studied by direct comparison. Then their characters were evaluated.


RESULTS
The active components could release more than 90% in 30 minutes and the pellets presented perfect sphericity and narrow diameter distribution.


CONCLUSIONS
Pellets of TCM can be prepared by homemade extrusion-spheronization machine and the fast-release pellets show perfect sphericity and narrow diameter distribution.
Hong
Yan-long
YL
Shuguang Hospital, Shanghai University of TCM, Shanghai 200021, China.
Feng
Yi
Y
Xu
De-sheng
DS
Jiang
Ling-hai
LH
Yang
Ying
Y
D019661:Apiaceae / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004338:Drug Combinations; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D000431:Ethanol / Q000737:chemistry; D031668:Gastrodia / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D014783:Viscosity
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010710:Phosphates; D000431:Ethanol; D002482:Cellulose; D007785:Lactose