title: Primate model of uveoretinitis and vasculitis/experimental autoimmune uveoretinitis induced in cynomolgus monkeys by retinal s antigen.
abstract: OBJECTIVE
  We aimed to describe the clinical and angiographic changes in an experimental model of autoimmune uveoretinitis and vasculitis in primates.
  
  
  METHODS
  Six cynomolgus monkeys received a single subcutaneous immunization with 100 microg of human S antigen with complete Freund's adjuvant.
  
  
  RESULTS
  All the animals had a bilateral long-term disease occurring usually in 1 eye approximately 4 weeks after immunization, the second eye being involved 1-5 weeks later. A cyclic course of the disease could be demonstrated by repeated fundus fluorescein angiograms. The initial and principal manifestation consisted in retinal vascular sheathing affecting veins and venules. The more severe forms showed areas of posterior uveoretinitis, dense vitritis and anterior uveitis.
  
  
  CONCLUSIONS
  A single systemic injection of pure human retinal S antigen could induce a chronic and recurrent ocular disease similar to human retinal vasculitis.
authors.affiliation: Department of Ophthalmology, University Pierre et Marie Curie, Pitié-Salpêtrière Medical School, Assistance Publique, Hôpitaux de Paris, Paris, France. phuc.lehoang@psl.aphp.fr
authors.forename: Phuc
authors.initials: P
authors.lastname: LeHoang
authors.forename: Margaret
authors.initials: M
authors.lastname: Sterkers
authors.forename: Brigitte
authors.initials: B
authors.lastname: Thillaye
authors.forename: Yvonne
authors.initials: Y
authors.lastname: de Kozak
authors.forename: Gabriel
authors.initials: G
authors.lastname: Coscas
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Faure
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D019393:Arrestin; D004195:Disease Models, Animal; D018450:Disease Progression; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005620:Freund's Adjuvant; D005654:Fundus Oculi; D007114:Immunization / Q000009:adverse effects; D017075:Laser Coagulation; D008252:Macaca fascicularis; D033401:Microscopy, Acoustic; D012008:Recurrence; D012160:Retina / Q000000981:diagnostic imaging / Q000473:pathology*; D031300:Retinal Vasculitis / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D012169:Retinal Vein / Q000473:pathology*; D012173:Retinitis / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D012720:Severity of Illness Index; D014605:Uveitis / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D014822:Vitreous Body / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D000276:Adjuvants, Immunologic; D019393:Arrestin; D005620:Freund's Adjuvant