title: Pedunculated hemangiopericytoma-like tumor: peculiar fibroepithelial polyp or fibrous histiocytoma variant.
abstract: Pathologists are continually challenged with the difficult task of discriminating between innocuous disease processes and potentially malignant entities. Apropos of this concern, we present a series of three cutaneous polypoid lesions that simulated fibroepithelial polyp, yet upon close scrutiny yielded histologic features of solitary fibrous tumor (SFT) or hemangiopericytoma. These pedunculated lesions showed a storiform pattern of spindled cells with interspersed gaping vascular channels reminiscent of SFT or hemangiopericytoma. Interestingly, the immunohistochemical staining profile of these lesions was negative for CD34 and positive for bcl-2 and factor XIIIa. These findings were discordant with SFT and suggest a relationship with fibrous histiocytoma. We propose that this entity represents a hitherto described variant of fibrous histiocytoma known as pedunculated hemangiopericytoma-like fibrous histiocytoma.
authors.affiliation: Department of Pathology, University of Maryland, College of Medicine, Baltimore, MD 21201, USA. JABrown@uams.edu
authors.forename: Jameel Ahmad
authors.initials: JA
authors.lastname: Brown
authors.forename: Michael B
authors.initials: MB
authors.lastname: Morgan
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis; D026122:Factor XIIIa / Q000096:biosynthesis; D005260:Female; D006393:Hemangiopericytoma / Q000378:metabolism / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D019253:Proto-Oncogene Proteins c-bcl-2; D026122:Factor XIIIa