title: Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products.
abstract: Dynamic nuclear polarization and dissolution of a (13)C-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 x 32 x 16 voxels every 3.5s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer.
authors.affiliation: Department of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont., Canada M4N 3M5. chuck@sri.utoronto.ca
authors.forename: Charles H
authors.initials: CH
authors.lastname: Cunningham
authors.forename: Albert P
authors.initials: AP
authors.lastname: Chen
authors.forename: Michael
authors.initials: M
authors.lastname: Lustig
authors.forename: Brian A
authors.initials: BA
authors.lastname: Hargreaves
authors.forename: Janine
authors.initials: J
authors.lastname: Lupo
authors.forename: Duan
authors.initials: D
authors.lastname: Xu
authors.forename: John
authors.initials: J
authors.lastname: Kurhanewicz
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Hurd
authors.forename: John M
authors.initials: JM
authors.lastname: Pauly
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Nelson
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Vigneron
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D002247:Carbon Isotopes; D007773:Lactates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051379:Mice; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
chemical_list: D002247:Carbon Isotopes; D007773:Lactates; D011773:Pyruvates