Genetics of post-traumatic stress disorder: informing clinical conceptualizations and promoting future research.
The purpose of this article is to provide an overview of genetic research involving post-traumatic stress disorder (PTSD). First, we summarize evidence for genetic influences on PTSD from family investigations. Second, we discuss the distinct contributions to our understanding of the genetics of PTSD permitted by twin studies. Finally, we summarize findings from molecular genetic studies, which have the potential to inform our understanding of underlying biological mechanisms for the development of PTSD.
Nugent
Nicole R
NR
Brown Medical School and Bradley/ Hasbro Children's Research Center, USA.
Amstadter
Ananda B
AB
Koenen
Karestan C
KC
D004200:Diseases in Twins / Q000209:etiology / Q000235:genetics / Q000523:psychology; D005191:Family Characteristics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008967:Molecular Biology; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000235:genetics* / Q000523:psychology; D018433:Twin Studies as Topic