title: Comparison of quantitative coronary angiography and first-pass perfusion magnetic resonance imaging for the detection of an impaired coronary perfusion in nonsevere coronary stenosis.
abstract: OBJECTIVE
  To compare quantitative coronary angiography (QCA) and first-pass perfusion magnetic resonance imaging (FPP-MRI) in symptomatic patients with nonsevere coronary stenosis to detect a reduced coronary flow velocity reserve (CFVR).
  
  
  METHODS
  In 35 patients, FPP-MRI and CFVR measurements were performed in 40 coronary arteries with a diameter stenosis (DS) <70% by QCA. From FPP-MRI a myocardial perfusion reserve index (MPRI) was calculated. CFVR was calculated as the ratio of the average peak flow velocity during infusion of adenosine and at rest and was considered reduced if <2. Diagnostic performance of MPRI and DS to detect a reduced CFVR was compared by receiver operating characteristic (ROC) curve analysis.
  
  
  RESULTS
  CFVR was reduced in 16 coronary arteries (40%). Mean DS did not differ in coronary arteries with a reduced CFVR (41.0% +/- 13.3) and a normal CFVR (36.5% +/- 12.3; P = 0.281). Mean MPRI was lower in coronary arteries with a reduced CFVR (1.12 +/- 0.12) compared to a normal CFVR (1.33 +/- 0.2; P < 0.001). Sensitivity, specificity, and area under the ROC curve (AUC) were higher for MPRI (81%, 79%, 0.84) than for DS (56%, 58%, 0.60).
  
  
  CONCLUSIONS
  FPP-MRI detects impaired CFVR in symptomatic patients with nonsevere coronary stenosis more accurately than QCA and can identify patients with symptomatic ischemia.
authors.affiliation: Department of Cardiology/Angiology, Center for Cardiology and Cardiovascular Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany. barmeyer@uke.uni-hamburg.de
authors.forename: Achim A
authors.initials: AA
authors.lastname: Barmeyer
authors.forename: Alexander
authors.initials: A
authors.lastname: Stork
authors.forename: Kai
authors.initials: K
authors.lastname: Muellerleile
authors.forename: Anne K
authors.initials: AK
authors.lastname: Schofer
authors.forename: Claudia
authors.initials: C
authors.lastname: Tiburtius
authors.forename: Ralf
authors.initials: R
authors.lastname: Koester
authors.forename: Thomas
authors.initials: T
authors.lastname: Heitzer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: Thomas
authors.initials: T
authors.lastname: Meinertz
authors.forename: Gunnar K
authors.initials: GK
authors.lastname: Lund
mesh_terms: D000241:Adenosine / Q000008:administration & dosage; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D003287:Contrast Media / Q000008:administration & dosage; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000503:physiopathology*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D012372:ROC Curve
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D000241:Adenosine