title: Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices.
abstract: Perioperative monitoring of blood coagulation is critical to better understand causes of hemorrhage, to guide hemostatic therapies, and to predict the risk of bleeding during the consecutive anesthetic or surgical procedures. Point-of-care (POC) coagulation monitoring devices assessing the viscoelastic properties of whole blood, i.e., thrombelastography, rotation thrombelastometry, and Sonoclot analysis, may overcome several limitations of routine coagulation tests in the perioperative setting. The advantage of these techniques is that they have the potential to measure the clotting process, starting with fibrin formation and continue through to clot retraction and fibrinolysis at the bedside, with minimal delays. Furthermore, the coagulation status of patients is assessed in whole blood, allowing the plasmatic coagulation system to interact with platelets and red cells, and thereby providing useful additional information on platelet function. Viscoelastic POC coagulation devices are increasingly being used in clinical practice, especially in the management of patients undergoing cardiac and liver surgery. Furthermore, they provide useful information in a large variety of clinical scenarios, e.g., massive hemorrhage, assessment of hypo- and hypercoagulable states, guiding pro- and anticoagulant therapies, and in diagnosing of a surgical bleeding. A surgical etiology of bleeding has to be considered when viscoelastic test results are normal. In summary, viscoelastic POC coagulation devices may help identify the cause of bleeding and guide pro- and anticoagulant therapies. To ensure optimal accuracy and performance, standardized procedures for blood sampling and handling, strict quality controls and trained personnel are required.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of CA San Francisco, San Francisco, California, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Ganter
authors.forename: Christoph K
authors.initials: CK
authors.lastname: Hofer
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests / Q000295:instrumentation / Q000379:methods / Q000592:standards; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006348:Cardiac Surgical Procedures; D003029:Coagulants / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods / Q000592:standards; D004548:Elasticity; D004867:Equipment Design; D018056:Hemorheology / Q000295:instrumentation / Q000379:methods / Q000592:standards; D006801:Humans; D008099:Liver / Q000601:surgery; D019990:Perioperative Care; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D019095:Point-of-Care Systems / Q000592:standards; D019106:Postoperative Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D011237:Predictive Value of Tests; D011787:Quality of Health Care; D015203:Reproducibility of Results; D013916:Thrombelastography; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D014783:Viscosity
chemical_list: D000925:Anticoagulants; D003029:Coagulants; D010975:Platelet Aggregation Inhibitors