title: Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.
abstract: OBJECTIVE
  Although commonly practiced in Japan, the effectiveness of regular screening with upper gastrointestinal (UGI) endoscopy against gastric cancer has not been well evidenced. The aim of the study was to investigate if gastric cancer-related mortality can be reduced by regular endoscopy.
  
  
  METHODS
  The medical records of 833 patients with gastric ulcer (GU) and 2547 without ulcer (NU) were analyzed; these patients received long-term, repeated endoscopic examinations between 1969 and 2004. Gastric cancer incidence, death by gastric cancer, and overall survival were compared with those in a Japanese general population by calculating the standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs).
  
  
  RESULTS
  The interval between UGI endoscopic examinations was 1.4 +/- 1.4 years in the GU group and 1.8 +/- 1.5 years in the NU group. During follow-up, 32 patients with GU and 61 in the NU group developed gastric cancer, showing annual incidence rates of 0.40% (95% CI: 0.24-0.56%) and 0.38% (0.28-0.48%), and SIRs of 2.21 (1.44-2.98) and 1.72 (1.29-2.15), respectively. The 5-year survival rate exceeded 80% among patients who developed gastric cancer. SMRs for gastric cancer and overall deaths were 0.50 (0.01-0.99) and 1.05 (0.87-1.23) in GU patients, and 0.45 (0.15-0.74) and 0.78 (0.69-0.88) in NU patients. There were no significant differences between the two groups in gastric cancer incidence, mortality from gastric cancer, and overall survival.
  
  
  CONCLUSIONS
  Mortality from gastric cancer could be reduced by regular UGI endoscopy in a population with a high incidence of gastric cancer.
authors.affiliation: Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan. masako-og@umin.ac.jp
authors.forename: Masako
authors.initials: M
authors.lastname: Ogura
authors.forename: Yohko
authors.initials: Y
authors.lastname: Hikiba
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsumura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Okano
authors.forename: Ryushi
authors.initials: R
authors.lastname: Sassa
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yoshida
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D005260:Female; D005773:Gastroscopy; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate