title: [Mechanisms of cerebral cortical development].
abstract: The development of cerebral cortex is regulated by complex mechanisms. Various classes of neurons migrate from the proliferative zones to the cortex according to a spatiotemporal manner. There are two distinct modes of neuronal migration: radial migration and tangential migration. In the benefit of the advancement of research techniques such as in utero electroporation and time-lapse observation of living tissues, more aspects of the cell and molecular mechanisms that control these two migration modes and their roles in the cortical development have been clarified.
authors.affiliation: Department of Anatomy, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakajima
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000502:physiology; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology*; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000502:physiology; D006801:Humans; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015816:Cell Adhesion Molecules, Neuronal; C115785:DAB1 protein, human; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D000091042:Reelin Protein; C469363:reelin receptor; D012697:Serine Endopeptidases