Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy.
We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.
Diagaradjane
Parmeswaran
P
Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Shetty
Anil
A
Wang
James C
JC
Elliott
Andrew M
AM
Schwartz
Jon
J
Shentu
Shujun
S
Park
Hee C
HC
Deorukhkar
Amit
A
Stafford
R Jason
RJ
Cho
Sang H
SH
Tunnell
James W
JW
Hazle
John D
JD
Krishnan
Sunil
S
D000818:Animals; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008027:Light; D008297:Male; D051379:Mice; D008819:Mice, Nude; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000627:therapeutic use*; D009389:Neovascularization, Pathologic / Q000473:pathology* / Q000628:therapy*; D011829:Radiation Dosage; D016896:Treatment Outcome
D006046:Gold