Cytokine profile of Armenian patients with Familial Mediterranean fever.
OBJECTIVE
Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.


METHODS
The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).


RESULTS
In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.


CONCLUSIONS
Inflammation in FMF involves Treg and Th17 lineages.
Manukyan
G P
GP
Group of Molecular and Cellular Immunology and Laboratory of Molecular Genetics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
Ghazaryan
K A
KA
Ktsoyan
Zh A
ZhA
Tatyan
M V
MV
Khachatryan
Z A
ZA
Hakobyan
G S
GS
Mkrtchyan
V A
VA
Kelly
D
D
Coutts
A
A
Aminov
R I
RI
D001136:Armenia; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D010505:Familial Mediterranean Fever / Q000097:blood*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000097:blood; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D016207:Cytokines; D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein