title: [Biochemical aspects of modified, transdermal replacement hormone therapy].
abstract: OBJECTIVE
  The aim of the study is to evaluate the influence of modified, transdermal, hormone replacement therapy [HRT] and hormone supplement therapy [HST] on concentration of FSH , LH, E1, E2, PR, IGF1, GH and bone density of lumbar vertebrae in women with osteopenia in postmenopausal period.
  
  
  METHODS
  65 women were enrolled, aged from 43 to 58, divided into three groups based on a randomized list. Group I control used transdermal placebo, group II used transdermal hormonal therapy [HRT] and group III used hormonal therapy per oss [HST]. The concentrations of hormones were estimate by radioimmunoenzymatic methods. Statistic analysis was based on Statistical PL.
  
  
  RESULTS
  After transdermal hormonal therapy [HRT], the concentration of hormones is normalized and there is a significant increase of bone density of lumbar vertebrae. Hormonal supplement therapy per oss [HST]. There is the decrease of IGF1, BMD, and increase of concentrations of estrogens, prolactin, GH.
  
  
  CONCLUSIONS
  1. Transdermal, hormone replacement therapy [HRT] modulates concentration of sex hormones and bone metabolism. 2. Hyperestrogenism, hyperprolactinemia, decreased IGF1 concentration and low mineral density in women after HST may cause disorders of chemical estrogens metabolism.
authors.affiliation: Pracownia Menopauzy i Andropauzy Pomorskiej Akademii Medycznej w Szczecinie.
authors.forename: Stanisław
authors.initials: S
authors.lastname: Stanosz
authors.forename: Ewa
authors.initials: E
authors.lastname: Zochowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stanosz
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000704:Analysis of Variance; D015519:Bone Density / Q000187:drug effects; D004964:Estriol / Q000097:blood; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004970:Estrone / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D016896:Treatment Outcome
chemical_list: D006065:Gonadotropins, Pituitary; D004970:Estrone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004964:Estriol