title: [Effects of extinction in multiple contexts on the renewal of associative tolerance to ethanol].
abstract: The Pavlovian analysis of drug tolerance describes how the contexts of drug administration participate in the elicitation of compensatory conditioned responses that are, at least partly, responsible for tolerance. Findings indicate that if an association is acquired in one context and extinguished in another one, when exposing the subjects to the acquisition context, renewal of the conditioned response will take place. Ambiguous evidence exists about whether or not this effect diminishes when extinguishing the association in multiple contexts. This investigation evaluates the existence of the phenomenon of renewal of tolerance to ethanol, and whether it diminishes by the extinction in multiple contexts. Evidence of renewal of tolerance to ethanol in rats was found, but no diminution was observed when extinguishing in multiple contexts.
authors.affiliation: Universidad de Chile, Santiago, Chile.
authors.forename: Ronald
authors.initials: R
authors.lastname: Betancourt Mainhard
authors.forename: Leonor
authors.initials: L
authors.lastname: Corada Luis
authors.forename: Juan
authors.initials: J
authors.lastname: Dominichetti Camus
authors.forename: Mario
authors.initials: M
authors.lastname: Laborda Rojas
authors.forename: Gabriel
authors.initials: G
authors.lastname: Martínez Miranda
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Miguel Cavieres
mesh_terms: D000818:Animals; D001245:Association Learning; D001290:Attitude; D003214:Conditioning, Classical; D004361:Drug Tolerance; D000431:Ethanol; D005108:Extinction, Psychological; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000431:Ethanol