title: Antifungal activity of crude extracts and fat-soluble constituents of Holotrichia diomphalia larvae.
abstract: In this study, chemical compositions of fatty oils and bioactivity of crude extracts from Holotrichia diomphalia larvae as Chinese materia medica were investigated for the first time. The chemical compositions of the fatty oils were obtained by two different methods and determined by GC/MS. In total, the petroleum ether extract produced 21 compounds (96.3%) while the supercritical fluid extract produced six compounds (99.53%) for identification. The effect of petroleum ether and other crude extracts on Pyricularia oryzae was also examined. Results indicated that ethanol and petroleum ether extracts had excellent antifungal activities. These findings demonstrated that fatty oils from H. diomphalia larvae had great potential to be used as a source for natural health products.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, GuoHe Road 325, Shanghai 200433, PR China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Dong
authors.forename: Jun-Lan
authors.initials: JL
authors.lastname: Wang
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Zhang
authors.forename: He
authors.initials: H
authors.lastname: Gao
authors.forename: Han-Ming
authors.initials: HM
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D025924:Chromatography, Supercritical Fluid; D001517:Coleoptera / Q000737:chemistry*; D045424:Complex Mixtures / Q000494:pharmacology*; D005223:Fats / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007814:Larva / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009821:Oils / Q000737:chemistry; D012995:Solubility / Q000187:drug effects
chemical_list: D000473:Alkanes; D000935:Antifungal Agents; D045424:Complex Mixtures; D005223:Fats; D009821:Oils; C004544:naphtha