title: Pilot study on the influence of corneal biomechanical properties over the short term in response to corneal refractive therapy for myopia.
abstract: OBJECTIVE
  To study the short-term corneal response to corneal refractive therapy for myopia and correlate it with corneal biomechanical properties as measured with the ocular response analyzer.
  
  
  METHODS
  Eight eyes from 8 young subjects were fitted with a reverse geometry contact lens, attempting a myopic correction of -4.00 D. Corneal resistance factor and corneal hysteresis (CH) were measured before contact lens fitting with the ocular response analyzer. These parameters were correlated with the degree of change in apical curvature, simulated keratometry, and central corneal thickness after 3 hours of contact lens wear (effect) and 3 hours after lens removal (recovery).
  
  
  RESULTS
  There was a trend toward a faster effect and faster recovery of the orthokeratologic effect for corneas with less resistance in terms of biomechanical properties. Corneal resistance factor did not correlate significantly, however, with any of the topographic and pachymetric parameters. Conversely, CH was significantly correlated with changes in steep keratometry (0.758; P = 0.029) and central corneal thickness (0.755; P = 0.030) during lens wear and with changes in steep keratometry (-0.835; P = 0.010) during recovery. Overall, higher values of CH meant slower effect and recovery of the orthokeratologic effect.
  
  
  CONCLUSIONS
  Short-term response of human cornea to corneal refractive therapy is correlated with the biomechanical properties of the cornea. Of the different theories supporting such involvement of corneal response to reverse geometry contact lenses, the most likely one seems to be the one assuming a faster response and faster recovery for corneas with lower resistance. Larger sample studies would be needed to clarify the involvement of corneal biomechanical properties on corneal response to orthokeratology.
authors.affiliation: Department of Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal. jgmeijome@fisica.uminho.pt
authors.forename: José Manuel
authors.initials: JM
authors.lastname: González-Méijome
authors.forename: César
authors.initials: C
authors.lastname: Villa-Collar
authors.forename: António
authors.initials: A
authors.lastname: Queirós
authors.forename: Jorge
authors.initials: J
authors.lastname: Jorge
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Parafita
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D003261:Contact Lenses; D003315:Cornea / Q000000981:diagnostic imaging / Q000502:physiology*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D054158:Orthokeratologic Procedures; D010865:Pilot Projects; D014463:Ultrasonography