title: Principles of and advances in immunoglobulin replacement therapy for primary immunodeficiency.
abstract: During the last 2 decades, the continued development and the large-scale production of polyclonal immune serum globulin (ISG) preparations with improved safety and tolerability profiles have allowed treatment to focus on quality of life and long-term freedom from the complications of primary immune deficiency disease, rather than just on freedom from severe acute infections and survival. Available ISG preparations allow routine therapy by a variety of routes and regimens that can be tailored to suit individual patients. Continued vigilance is required, however, because problems with emerging diseases, and the costs and availability of ISG are likely to present continuing challenges.
authors.affiliation: Division of Pediatric Allergy and Immunology, Case Western Reserve University, University Hospitals of Cleveland/Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, MS: RBC 6008B, Cleveland, OH 44106, USA. melvin.berger@uhhs.com
authors.forename: Melvin
authors.initials: M
authors.lastname: Berger
mesh_terms: D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D007279:Injections, Subcutaneous
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous