Electrode commutation sequence for honeycomb arrangement of electrodes in electrochemotherapy and corresponding electric field distribution.
Electrochemotherapy is a treatment based on combination of chemotherapeutic drug and electroporation. It is used in clinics for treatment of solid tumours. For electrochemotherapy of larger tumours multiple needle electrodes were already suggested. We developed and tested electrode commutation circuit, which controls up to 19 electrodes independently. Each electrode can be in one of three possible states: on positive or negative potential or in the state of high impedance. In addition, we tested a pulse sequence using seven electrodes for which we also calculated electric field distribution in tumour tissue by means of finite-elements method. Electrochemotherapy, performed by multiple needle electrodes and tested pulse sequence on large subcutaneous murine tumour model resulted in tumour growth delay and 57% complete responses, thus demonstrating that the tested electrode commutation sequence is efficient.
Rebersek
Matej
M
University of Ljubljana, Faculty of Electrical Engineering, Trzaska 25, SI-1000 Ljubljana, Slovenia. damijan.miklavcic@fe.uni-lj.si
Corović
Selma
S
Sersa
Gregor
G
Miklavcic
Damijan
D
D000818:Animals; D049109:Cell Proliferation; D053672:Electrochemotherapy / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D018274:Electroporation; D020342:Finite Element Analysis; D051379:Mice; D009369:Neoplasms / Q000628:therapy; D016896:Treatment Outcome