title: Expression of interleukin-10 in patients with adenomyosis.
abstract: OBJECTIVE
  To investigate the expression of interleukin-10 (IL-10) in adenomyosis.
  
  
  METHODS
  Laboratory study using human tissue.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirty-four patients with adenomyosis and 30 women without adenomyosis who underwent hysterectomy for nonendometrial pathology.
  
  
  METHODS
  Tissue sections were immunostained with murine monoclonal antihuman IL-10 antibodies.
  
  
  METHODS
  Microscopic evaluation to assess the presence and localization of IL-10 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with IL-10 expression in the normal endometrium.
  
  
  RESULTS
  In the eutopic and ectopic endometrium of women with adenomyosis, epithelial cells showed higher staining intensity than the normal controls. However, no significant differences were found in the epithelial IL-10 immunostaining H score values between the eutopic endometrium and adenomyosis foci. Nonetheless, we observed a cyclic variation in the eutopic epithelial IL-10 immunoreactivity throughout the menstrual cycle with higher H score values in the secretory phase than in the proliferative phase.
  
  
  CONCLUSIONS
  These findings suggest that an abnormality of inflammatory response may be present in the eutopic and ectopic endometrium of women with adenomyosis and that IL-10 may contribute to the pathogenesis and pathophysiology of adenomyosis.
authors.affiliation: Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Yang
authors.forename: Xuelian
authors.initials: X
authors.lastname: Du
authors.forename: Min
authors.initials: M
authors.lastname: Cui
authors.forename: Zeqing
authors.initials: Z
authors.lastname: Wen
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000276:immunology*; D004717:Endometrium / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000032:analysis*; D008875:Middle Aged; D014591:Uterine Diseases / Q000276:immunology*
chemical_list: D016753:Interleukin-10