title: Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing.
abstract: Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans.
authors.affiliation: Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK.
authors.forename: Mette D
authors.initials: MD
authors.lastname: Jacobsen
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Davidson
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Li
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Shaw
authors.forename: Neil A R
authors.initials: NA
authors.lastname: Gow
authors.forename: Frank C
authors.initials: FC
authors.lastname: Odds
mesh_terms: D002176:Candida albicans / Q000235:genetics; D041022:Candida tropicalis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D006239:Haplotypes; D006801:Humans; D016533:Mycological Typing Techniques; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic