title: Observational studies of statins in heart failure with preserved systolic function.
abstract: This article reviews the available evidence from observational studies concerning the effect of statin therapy in patients who have heart failure and a preserved ejection fraction (diastolic heart failure). Observational studies suggest that statin therapy is associated with lower mortality in patients who have diastolic heart failure. These results emphasize the need for a randomized study of the effect of statins in diastolic heart failure. Until the results of such studies are available, it is recommended to use statins in patients with diastolic heart failure who otherwise have an indication for statin therapy.
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Fukuta
authors.forename: William C
authors.initials: WC
authors.lastname: Little
mesh_terms: D000368:Aged; D003971:Diastole; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D013599:Systole
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors