title: Synthesis of protected 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides.
abstract: This unit describes in detail the preparation of protected 2'-deoxy-2'-fluoroarabinonucleosides. These building blocks are required for the synthesis of 2'-deoxy-2'-fluoroarabinonucleic acid (2'F-ANA), an oligonucleotide analog exhibiting very promising antisense properties. The preparation of phosphoramidites from these building blocks and the synthesis of 2'F-ANA are described elsewhere in the manual.
authors.affiliation: McGill University, Montreal, Canada.
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Elzagheid
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Viazovkina
authors.forename: Masad J
authors.initials: MJ
authors.lastname: Damha
mesh_terms: D000577:Amides; D001087:Arabinonucleosides / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods; D003855:Deoxyribose; D005461:Fluorine; D008722:Methods; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis; D010756:Phosphoric Acids
chemical_list: D000577:Amides; D001087:Arabinonucleosides; D009838:Oligodeoxyribonucleotides; D010756:Phosphoric Acids; D005461:Fluorine; D003855:Deoxyribose; C011067:phosphoramidic acid