title: Renal pathology of ANCA-related vasculitis: proposal for standardization of pathological diagnosis in Japan.
abstract: BACKGROUND
  In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Group (EUVAS) classification. Therefore, a histological common basis is needed to compare Japanese histological data with the international database.
  
  
  METHODS
  Histological parameters concerning glomerular, tubulointerstitial, and vascular lesions of ANCA-related vasculitis, which are indispensable for clinical management, were elucidated and defined by reviewing, utilizing the merits of, and amending the two scoring systems.
  
  
  CONCLUSIONS
  A new comprehensive and standardized scoring system, by which histological quantitative assessment can provide evidence for therapy planning, has been developed for renal biopsy of Japanese ANCA-related vasculitis.
authors.affiliation: Division of Renal Pathology, Clinical Research Center, Chiba-East National Hospital, Chiba, Japan. johken@cehprinet.com.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Joh
authors.affiliation: Division of Nephrology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Muso
authors.affiliation: Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Shigematsu
authors.affiliation: Department of Pathogenomics, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Nose
authors.affiliation: Department of Molecular Pathology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Nagata
authors.affiliation: First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Arimura
authors.affiliation: Department of Nephrology and Kidney Center, Department of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.affiliation: Department of Laboratory Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Kousaku
authors.initials: K
authors.lastname: Nitta
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
authors.affiliation: Department of Nephrology, Sendai Shakaihoken Hospital, Miyagi, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Taguma
authors.affiliation: Department of Medical Nursing, Fukuoka University School of Nursing, Fukuoka, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kaneoka
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Yuhsuke
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Internal Medicine, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Ibaraki Prefectural University of Health Science, Ibaraki, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Koyama
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Joichi
authors.initials: J
authors.lastname: Usui
authors.affiliation: Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.affiliation: Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ozaki
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomino
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D001706:Biopsy; D019937:Diagnostic Techniques and Procedures / Q000592:standards*; D005060:Europe; D006801:Humans; D007564:Japan; D007668:Kidney / Q000473:pathology*; D014657:Vasculitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic