Successful pregnancies treated with pioglitazone in infertile patients with polycystic ovary syndrome.
OBJECTIVE
To investigate the efficacy of pioglitazone on fecundity in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as clomiphene, dexamethasone, or metformin.


METHODS
A retrospective pilot study.


METHODS
Department of Obstetrics and Gynecology in a general hospital.


METHODS
Nine infertile women with PCOS.


METHODS
Pioglitazone, 15-30 mg/day, up to 32 weeks.


METHODS
Pregnancy rate.


RESULTS
Seven of nine women became pregnant at an average of 11.3 weeks of initiation of pioglitazone. Four of seven pregnant cases conceived after the first successful induction of ovulation with the initiation of pioglitazone, and two cases conceived after the second cycle. Three women have already delivered, and there is one ongoing pregnancy. The other three cases ended in miscarriage during the sixth or eighth week of pregnancy.


CONCLUSIONS
Pioglitazone may be effective in infertile patients with resistant PCOS.
Ota
Hirotaka
H
Department of Obstetrics and Gynecology, Akita Red Cross Hospital, Akita, Japan. otahiro@archosp-1998.com
Goto
Takashi
T
Yoshioka
Tomomi
T
Ohyama
Noriaki
N
D000328:Adult; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007247:Infertility, Female / Q000150:complications* / Q000188:drug therapy*; D000077205:Pioglitazone; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D045162:Thiazolidinediones / Q000008:administration & dosage*; D016896:Treatment Outcome
D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077205:Pioglitazone