Mechanisms involved in the regulation of histone lysine demethylases.
Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.
Lan
Fei
F
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. fei_lan@student.hms.harvard.edu
Nottke
Amanda Clair
AC
Shi
Yang
Y
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D056466:Histone Demethylases; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D006657:Histones; D014157:Transcription Factors; D056466:Histone Demethylases; C495195:KDM1A protein, human; D010089:Oxidoreductases, N-Demethylating