Understanding proteasome assembly and regulation: importance to cardiovascular medicine.
The cardiac proteasome is increasingly recognized as a complex, heterogeneous, and dynamic organelle contributing to the modulation of cardiac function in health and diseases. The emerging picture of the proteasome system reveals a highly regulated and organized molecular machine integrated into multiple biologic processes of the cell. Full appreciation of its cardiovascular relevance requires an understanding of its proteolytic function as well as its underlying regulatory mechanisms, of which assembly, stoichiometry, posttranslational modification, and the role of the associating partners are increasingly poignant.
Young
Glen W
GW
Department of Physiology, Medicine/Division of Cardiology, David Geffen School of Medicine at UCLA, University of California-Los Angeles, CA 90095, USA.
Wang
Yueju
Y
Ping
Peipei
P
D000818:Animals; D006331:Heart Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D015388:Organelles / Q000378:metabolism / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism
D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex