Transient directional disorientation as a manifestation of cerebral ischemia.
The authors describe 2 patients who presented with transient directional disorientation (TDD) as a manifestation of cerebral ischemia. The patients suddenly lost sense of direction in a familiar environment despite preserved ability to recognize landmarks, and recovered within a short time. Brain MRI revealed an ischemic lesion in the right medial occipital lobe and the corpus callosum in case 1 and in the right parieto-occipital sulcus (POS) in case 2. After ictus, fMRI study of a navigation task was performed, which demonstrated the activation of the POS unilaterally in case 1 and bilaterally in case 2. We propose that TDD of our patients is related to temporary dysfunction of bilateral POS.
Ino
Tadashi
T
Department of Neurology, Rakuwakai-Otowa Hospital, Kyoto, Japan. rakuwadr042@rakuwadr.com
Usami
Hideo
H
Tokumoto
Kazuki
K
Kimura
Toru
T
Ozawa
Kyoko
K
Nakamura
Shigenobu
S
D000368:Aged; D001364:Awareness; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D048909:Diabetes Complications / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D020300:Intracranial Hemorrhages / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging; D008297:Male; D009949:Orientation; D021641:Recognition, Psychology; D013028:Space Perception; D013037:Spatial Behavior