Mitochondrial involvement in psychiatric disorders.
Recent findings of mitochondrial abnormalities in brains from subjects with neurological disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. A growing body of evidence suggests that there is mitochondrial dysfunction in schizophrenia, bipolar disorder, and major depressive disorder, including evidence from electron microscopy, imaging, gene expression, genotyping, and sequencing studies. Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examination of mitochondrial DNA from postmortem brain cells may provide further details of mitochondrial alterations in psychiatric disorders.
Shao
Ling
L
Department of Psychiatry & Human Behavior, University of California, Irvine, Irvine CA, USA.
Martin
Maureen V
MV
Watson
Stanley J
SJ
Schatzberg
Alan
A
Akil
Huda
H
Myers
Richard M
RM
Jones
Edward G
EG
Bunney
William E
WE
Vawter
Marquis P
MP
D000818:Animals; D001714:Bipolar Disorder / Q000235:genetics / Q000503:physiopathology; D004272:DNA, Mitochondrial / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000235:genetics / Q000503:physiopathology; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000503:physiopathology*; D008854:Microscopy, Electron; D028361:Mitochondrial Diseases / Q000235:genetics / Q000503:physiopathology*; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology
D004272:DNA, Mitochondrial