title: Prognostic factors of cutaneous melanoma in relation to metastasis at the sentinel lymph node: a case-controlled study.
abstract: BACKGROUND
  The selection of patients who will undergo sentinel lymph node biopsy is primarily based on the histopathologic features of cutaneous melanoma. The purpose of this study is to identify prognostic factors that predict the sentinel lymph node metastasis in melanoma.
  
  
  METHODS
  Sixty-nine melanoma patients underwent sentinel lymph node biopsy at Padova Plastic Surgery Institute. Univariate chi-square and multivariate logistic regression analyses were conducted to identify the relationship between prognostic factors and positive sentinel lymph node. A Receiver Operating Characteristics (ROC) Curve was performed to identify the ideal Breslow thickness cutpoint at which to perform sentinel node biopsy.
  
  
  RESULTS
  Eleven of the 69 patients (16%) had sentinel lymph node metastases. By univariate analyses Breslow's thickness (p=0.001), ulceration (p=0.001), and lymphovascular invasion (p<0.0001) were found to be significant prognostic factors for the prediction of sentinel node micrometastases. The ROC Curve identified a Breslow thickness of 1.19 mm to be the most suitable cutpoint for sentinel lymph node positivity (p=0.003, sensibility 80%, specificity 69.6%).
  
  
  CONCLUSIONS
  Patients with Breslow thickness >or=1.19 mm, ulceration, and lymphovascular invasion are at higher risk for occult lymph node metastases. In addition it is important to use multiple selection criteria when performing sentinel lymph node biopsy especially in patients with thin melanomas.
authors.affiliation: Department of Medical and Surgical Sciences, Institute of Plastic Surgery, Padova University Hospital, 2 Giustiniani Street, Post Code 35128 Padova, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sartore
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Papanikolaou
authors.forename: Fausto
authors.initials: F
authors.lastname: Biancari
authors.forename: Francesco
authors.initials: F
authors.lastname: Mazzoleni
mesh_terms: D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology*; D012883:Skin Ulcer / Q000473:pathology