Biotransformation of tetrahydro-alpha-santonins by Absidia coerulea.
The fungus, Absidia coerulea was employed to bioconvert tetrahydro-alpha-santonins, 1,2,4alpha,5alpha-tetrahydro-alpha-santonin (1), and its 4-epimer (2), from which 10 products (3-12) were obtained. Furthermore, their structures were determined, based on their chemical and spectroscopic data analyses. Among them, 3-5, 7, 9, 11 and 12 were observed to be seven new compounds. The reactions mainly involved in these bio-process included hydroxylation(s) (C-4, C-11, and C-1), reduction (C-3 ketone to alcohol).
Yang
Lin
L
College of Life and Environmental Sciences, The Central University for Nationalities, Beijing, P.R. China.
Dai
Jungui
J
D020095:Absidia / Q000378:metabolism*; D001711:Biotransformation; D001330:Electronic Data Processing; D006900:Hydroxylation; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D012500:Santonin / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
D007783:Lactones; D012500:Santonin