title: Anesthesia.
abstract: Anesthetic agents are used in laboratory animals to prevent pain or distress due to an experimental procedure or for restraint to facilitate a technically difficult procedure. This unit provides three basic protocols: injectable anesthesia for mouse, rat, and hamster; inhalant anesthesia using methoxyflurane for mouse, rat, and hamster; and injectable anesthesia using ketamine/xylazine for rabbit. An Alternate Protocol describes sedation using butorphanol/acetylpromazine in the rabbit. The Commentary further describes and compares these methods of anesthesia for various applications.
authors.affiliation: Rhone-Poulenc Rorer, Collegeville, Pennsylvania, USA.
authors.forename: J
authors.initials: J
authors.lastname: Donovan
authors.forename: P
authors.initials: P
authors.lastname: Brown
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage; D000758:Anesthesia / Q000379:methods*; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000008:administration & dosage*; D000818:Animals; D002077:Butorphanol / Q000008:administration & dosage; D006224:Cricetinae; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007649:Ketamine / Q000008:administration & dosage; D008733:Methoxyflurane / Q000008:administration & dosage; D051379:Mice; D011817:Rabbits; D051381:Rats; D014991:Xylazine / Q000008:administration & dosage
chemical_list: D000777:Anesthetics; D014991:Xylazine; D008733:Methoxyflurane; D000075:Acepromazine; D007649:Ketamine; D002077:Butorphanol