title: Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines.
abstract: The first indirubin-N'-glycosides were prepared based on reactions of isatin-N'-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N'-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N'-rhamnosides.
authors.affiliation: Institut für Chemie der Universität Rostock, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Libnow
authors.forename: Karen
authors.initials: K
authors.lastname: Methling
authors.forename: Martin
authors.initials: M
authors.lastname: Hein
authors.forename: Dirk
authors.initials: D
authors.lastname: Michalik
authors.forename: Manuela
authors.initials: M
authors.lastname: Harms
authors.forename: Kristian
authors.initials: K
authors.lastname: Wende
authors.forename: Anke
authors.initials: A
authors.lastname: Flemming
authors.forename: Martin
authors.initials: M
authors.lastname: Köckerling
authors.forename: Helmut
authors.initials: H
authors.lastname: Reinke
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Bednarski
authors.forename: Michael
authors.initials: M
authors.lastname: Lalk
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D007211:Indoles; C027185:indirubin