title: [Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography].
abstract: To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.
  
  
  
  An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.
  
  
  
  Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.
  
  
  
  The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.
authors.affiliation: Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Gui-feng
authors.initials: GF
authors.lastname: Deng
authors.forename: Tong-wei
authors.initials: TW
authors.lastname: Yao
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control; D017829:Granisetron / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis; D013463:Sulfuric Acid Esters / Q000032:analysis*
chemical_list: D017829:Granisetron; D004364:Pharmaceutical Preparations; D013463:Sulfuric Acid Esters; C007482:dimethyl sulfate