title: Inflammation and genomics in the critical care unit.
abstract: Inflammation is a physiologic response to irritants, injury, and infection. Inflammatory dysregulation is believed to contribute to mortality and morbidity in illnesses common to critical care units, such as burns, trauma, sepsis, and cardiovascular disease. This article reviews the approaches used to investigate the molecular basis of inflammatory function. Genomic findings are providing insight into clinical diagnosis and treatment of inflammatory derangements in critically ill patients.
authors.affiliation: Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH 44206, USA. chris.winkelman@case.edu
authors.forename: Chris
authors.initials: C
authors.lastname: Winkelman
mesh_terms: D016718:Arachidonic Acid / Q000235:genetics; D001777:Blood Coagulation / Q000235:genetics; D002874:Chromosome Mapping; D003165:Complement System Proteins / Q000235:genetics; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy; D016207:Cytokines / Q000235:genetics; D023082:Defensins / Q000235:genetics; D020869:Gene Expression Profiling; D014644:Genetic Variation / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006632:Histamine / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008967:Molecular Biology / Q000379:methods*; D024802:Nurse's Role; D009730:Nursing Assessment; D040901:Proteomics; D018570:Risk Assessment; D013041:Specialties, Nursing / Q000379:methods; D051193:Toll-Like Receptors / Q000235:genetics
chemical_list: D016207:Cytokines; D023082:Defensins; D051193:Toll-Like Receptors; D016718:Arachidonic Acid; D006632:Histamine; D003165:Complement System Proteins