Bone repair following bone grafting hydroxyapatite guided bone regeneration and infra-red laser photobiomodulation: a histological study in a rodent model.
The aim of the investigation was to assess histologically the effect of laser photobiomodulation (LPBM) on a repair of defects surgically created in the femurs of rats. Forty-five Wistar rats were divided into four groups: group I (control); group II (LPBM); group III (hydroxyapatite guided bone regeneration; HA GBR); group IV (HA GBR LPBM). The animals in the irradiated groups were subjected to the first irradiation immediately after surgery, and it was repeated every day for 2 weeks. The animals were killed 15 days, 21 days and 30 days after surgery. When the groups irradiated with implant and membrane were compared, it was observed that the repair of the defects submitted to LPBM was also processed faster, starting from the 15th day. At the 30th day, the level of repair of the defects was similar in the irradiated groups and those not irradiated. New bone formation was seen inside the cavity, probably by the osteoconduction of the implant, and, in the irradiated groups, this new bone formation was incremental. The present preliminary data seem to suggest that LPMB therapy might have a positive effect upon early wound healing of bone defects treated with a combination of HA and GBR.
Pinheiro
Antonio Luiz B
AL
Department of Propedeutica and Clínica Integrada, Laser Center, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil. albp@ufba.br
Martinez Gerbi
Marleny E
ME
de Assis Limeira
Francisco
F
Carneiro Ponzi
Elizabeth Arruda
EA
Marques
Aparecida M C
AM
Carvalho
Carolina Montagn
CM
de Carneiro Santos
Rafael
R
Oliveira
Priscila Chagas
PC
Nóia
Manuela
M
Ramalho
Luciana Maria Pedreira
LM
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000528:radiation effects*; D003131:Combined Modality Therapy; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000473:pathology* / Q000503:physiopathology / Q000528:radiation effects; D048091:Guided Tissue Regeneration / Q000379:methods*; D028022:Low-Level Light Therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001672:Biocompatible Materials; D017886:Durapatite