NF-kappaB and cancer-identifying targets and mechanisms.
A connection between inflammation and carcinogenesis has long been known, but the precise mechanisms are just beginning to be understood. NF-kappaB proteins, transcription factors which integrate stress signals and orchestrate immune responses, have also recently been linked to carcinogenesis. Hallmarks of cancer development include self-sufficiency in growth signals, insensitivity to growth-inhibitors, evasion of apoptosis, limitless replicative potential, tissue invasion and metastasis, and sustained angiogenesis. NF-kappaB signaling has been implicated in each of these hallmarks, and recent experimental studies have illuminated the mechanistic pathways by which NF-kappaB signaling contributes to these aspects of carcinogenesis. This review will focus on recent experimental data supporting the hypothesis that inflammation promotes carcinogenesis, and that NF-kappaB signaling is at the heart of such inflammation.
Naugler
Willscott E
WE
Department of Medicine, Division of Gastroenterology and Hepatology, Oregon Health and Sciences University, Portland, USA.
Karin
Michael
M
D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D007249:Inflammation / Q000150:complications*; D016328:NF-kappa B / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000473:pathology; D009389:Neovascularization, Pathologic; D015398:Signal Transduction
D016328:NF-kappa B