title: Psychotic mania associated with mefloquine in a bipolar patient.
abstract: A 63-year-old male patient with a history of bipolar I disorder presented to the emergency department in an acutely psychotic state. The patient had just returned from vacation in a malarial high-risk area and, as a result, had taken five weekly doses of mefloquine for prophylaxis. The patient's bipolar disorder was being treated with lithium, and he had been stable for about 8 years. All organic causes of psychosis were ruled out. The patient was admitted to the inpatient psychiatric unit and was treated with quetiapine until he was stable enough to return home.
authors.affiliation: Pharmacy Department, Alegent Health, Immanuel Medical Center, Omaha, NE 68122, USA. mbrumbau@alegent.org
authors.forename: Meredith
authors.initials: M
authors.lastname: Brumbaugh
authors.forename: Paul
authors.initials: P
authors.lastname: Price
authors.forename: Nancy
authors.initials: N
authors.lastname: Fagan
authors.forename: Hudson
authors.initials: H
authors.lastname: Hsieh
mesh_terms: D000962:Antimalarials / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001714:Bipolar Disorder / Q000188:drug therapy; D000075202:Contraindications; D018450:Disease Progression; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage; D008288:Malaria / Q000517:prevention & control; D008297:Male; D015767:Mefloquine / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D000962:Antimalarials; D014150:Antipsychotic Agents; D018020:Lithium Compounds; D015767:Mefloquine