title: Urinary leukotrienes in patients with nasal polyposis.
abstract: OBJECTIVE
  To compare urinary leukotriene E4 (ULT) level in patients with nasal polyposis (NP) with and without aspirin intolerance and allergic rhinitis (AR), and correlate it with disease severity.
  
  
  METHODS
  Prospective study from November 2005 to November 2006. Patients with NP (n = 30) and AR (n = 35) were included. The concentration of ULT was measured in both groups. Oral provocation test with aspirin was performed to patients with NP. ULT level between both groups was compared and correlated with NP disease severity.
  
  
  RESULTS
  ULT concentration was elevated on NP and AR. The patients with NP and aspirin intolerance (n = 4) presented higher levels of ULT compared to aspirin-tolerant patients. Leukotriene concentration was not correlated with NP severity.
  
  
  CONCLUSIONS
  Patients with NP and aspirin intolerance have increased ULT excretion; thus their measurement can be used as an indicator of arachidonic acid metabolism alteration.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hospital Clínico Universidad de Chile, Santiago, Chile. nazorej@yahoo.com
authors.forename: Michel
authors.initials: M
authors.lastname: Royer
authors.forename: María Antonieta
authors.initials: MA
authors.lastname: Guzmán
authors.forename: Juan-Pablo
authors.initials: JP
authors.lastname: Gormaz
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Nazar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017999:Leukotriene E4 / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000652:urine*; D011446:Prospective Studies
chemical_list: D017999:Leukotriene E4