[The role of metalloproteinases and their inhibitors in pancreatic cancer].
Pancreatic cancer is characterized by aggressive behavior, poor prognosis, and predicted shortened survival. It is a major cause of cancer death in Europe and North America. Matrix metalloproteinases and their inhibitors play an important role in tumor progression. MMPs are able to degrade basement membrane and extracellular matrix and are associated with tumor progression, including invasion, metastasis, growth, migration, and angiogenesis. Some clinical investigations have demonstrated the role of increased MMP expression in several human malignancies, their levels also correlating with tumor stage, invasiveness, and poor survival of patients with pancreatic cancer.
Łukaszewicz
Marta
M
Zakład Diagnostyki Biochemicznej Akademii Medycznej w Białymstoku, ul. J. Waszyngtona 15a, 15-274 Białystok. martha_21@interia.pl
Mroczko
Barbara
B
Szmitkowski
Maciej
M
D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D018450:Disease Progression; D005060:Europe; D006801:Humans; D007150:Immunohistochemistry; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism; D009656:North America; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases