[Dynamics of biochemical parameters in patients with anxious depression treated with serotonergic antidepressants with different mechanisms of action].
The aim of the study was to compare the dynamics of some biochemical parameters in patients with anxious depression treated with tianeptine (coaxil) - serotonin reuptake enhancer and sertraline (zofort) - selective serotonin reuptake inhibitor. Forty-three patients with ICD-10 diagnosis of anxious depression (F32.1 and F33.1) were included in the study. Comparing to healthy volunteers, the significant increase of platelet monoamine oxidase activity by 95% and concentration of middle molecules (middle-mass endotoxic molecules) by 86% and decrease of serum amine oxidase activity by 43% and functional albumin activity by 38% was found in patients. An analysis of the biochemical profiles revealed the changes in opposite directions of all investigated parameters for antidepressants with different effects on serotonin reuptake though both tianeptine and sertraline were effective in the treatment of anxious depression.
Uzbekov
M G
MG
Maksimova
N M
NM
Misionzhnik
E Iu
EIu
Vetrogradova
O P
OP
D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000378:metabolism*; D000700:Analgesics; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001007:Anxiety / Q000097:blood* / Q000188:drug therapy; D001792:Blood Platelets / Q000201:enzymology; D003863:Depression / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use; D013841:Thiazepines / Q000627:therapeutic use; D016896:Treatment Outcome
D000418:Albumins; D000700:Analgesics; D000929:Antidepressive Agents, Tricyclic; D008995:Monoamine Oxidase; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D013841:Thiazepines; C050504:tianeptine