title: HNA-1a, HNA-1b and HNA-1c gene frequencies in Argentineans.
abstract: Human neutrophil antigens (HNA) are polymorphic structures located in the neutrophil membrane. The neutrophil-specific antigens HNA-1a (NA1), 1b (NA2) and 1c (SH) are well-recognized allotypic forms of FcgammaRIIIb and the most frequent targets of neutrophil alloantibodies. The aim of this study was to determine the gene frequencies of the neutrophil-specific antigens belonging to the HNA-1 system in blood donors and Toba Amerindians from Rosario, Argentina. Two hundred and eighteen unrelated healthy Argentinean blood donors and Toba Amerindians from Rosario were typed for HNA-1a, HNA-1b and HNA-1c using polymerase chain reaction with sequence-specific primers. For the Argentinean blood donors, the HNA-1a and HNA-1b gene frequencies were 0.44 and 0.56 and for the Amerindians Toba were 0.77 and 0.23, respectively. The HNA-1c antigen is present in 4.7% (gene frequency=0.023) of the blood donors but in none of the Amerindian individuals. The present data showed that the HNA-1 allele frequencies in the major population and the Toba Amerindians from Rosario are similar to those described in European and others distant Amerindians populations, respectively.
authors.affiliation: Servicio de Medicina Transfusional, Hospital Italiano Garibaldi, Rosario, Argentina. daniel.delavega@yahoo.com
authors.forename: C D
authors.initials: CD
authors.lastname: de La Vega Elena
authors.forename: N
authors.initials: N
authors.lastname: Nogués
authors.forename: A
authors.initials: A
authors.lastname: Fernández Montoya
authors.forename: S
authors.initials: S
authors.lastname: Oyonarte
authors.forename: E
authors.initials: E
authors.lastname: Solis
authors.forename: E
authors.initials: E
authors.lastname: Muñiz-Díaz
mesh_terms: D000483:Alleles; D001118:Argentina; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D007519:Isoantigens / Q000235:genetics*; D009504:Neutrophils / Q000276:immunology*
chemical_list: D007519:Isoantigens; C067704:neutrophil-specific antigen NA1, human