title: Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement.
abstract: Information concerning the prognosis of subsequent pregnancies in patients with reciprocal translocations is limited. This study was performed to determine the percentage success rate with first pregnancies after ascertainment of a carrier status. A total of 2,382 couples with a history of two or more consecutive miscarriages were studied in multicenters. The prevalence of an abnormal chromosome in either partner was examined, and subsequent success rates were compared between cases with and without an abnormal karyotype in either partner. A total of 129 couples (5.4%) had an abnormal karyotype in one partner excluding inversion 9 in 44 men and in 85 women. Thus, 2,253 couples had a normal karyotype in both partner. Eighty-five (3.6%) had translocations, 13 being Robertsonian translocations. Twenty-nine of the 46 cases (63.0%) who became pregnant with reciprocal translocations in either partner experienced a live birth with natural conception. In contrast, 950 of 1,207 cases (78.7%) with normal chromosomes had successful live births, the difference being significant (P = 0.019). No infant with an unbalanced translocation was found in 29 cases of successful pregnancy following recurrent miscarriage. Pregnancy prognosis was worsened with either maternal or paternal reciprocal translocations. Explanation of the success rate with natural conception should be provided before the subsequent pregnancy after ascertainment of carrier status.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan. og.mym@med.nagoya-cu.ac.jp.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugiura-Ogasawara
authors.affiliation: Aoki Ladies Clinic, Nagoya, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Aoki
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Department of Maternal Medicine, Osaka Prefectural Hospital Organization, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan.
authors.forename: Tomio
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Kawaguchi
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maruyama
authors.affiliation: Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ozawa
authors.affiliation: Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Sugi
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takeshita
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005220:Fathers; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D007246:Infertility / Q000235:genetics; D008297:Male; D009035:Mothers; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D011446:Prospective Studies; D014178:Translocation, Genetic