title: [Dynamics of cardiovascular system functional state indices in patients with idiopathic mitral valve prolapse against the background of magnerot and alprazolam therapy].
abstract: 144 patients with idiopathic mitral valve prolapse (MVP) were examined. They were divided into groups of treatment with magnerot, and placebo (control group). Decrease of echocardiography indices of MVP was noticed in the patients who received magnerot. After therapy with alprazolam only tendency to decrease of prolapse depth was registered. Significant decrease of maximal systolic and diastolic pressure, mean diastolic pressure, hypertonic load with diastolic pressure and increased variability of systolic and diastolic pressure occurred after therapy with magnerot. Decrease of systolic and diastolic pressure was noticed after therapy with alprazolam. At Halter monitoring of patients with MVP were noticed that magnerot had greater effect than alprazolam to decrease of number of tachycardia (paroxysmal supraventricual and nonparoxysmal) episodes. Significant decrease of number of patients with sympathicotonia and, at the same time, increase of number of person with equal tonus of both vegetative nervous systems were registered after therapy with magnerot (by 9 times) and with alprazolam (by 4.5 times).
authors.forename: E V
authors.initials: EV
authors.lastname: Akatova
authors.forename: E D
authors.initials: ED
authors.lastname: Sukhanova
authors.forename: O O
authors.initials: OO
authors.lastname: Mel'nik
authors.forename: A I
authors.initials: AI
authors.lastname: Martynov
mesh_terms: D000525:Alprazolam / Q000494:pharmacology* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology* / Q000627:therapeutic use*; D005942:Gluconates / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology
chemical_list: D018757:GABA Modulators; D005942:Gluconates; C030691:gluconic acid; D000525:Alprazolam