Synthesis of exemestane labelled with (13)C.
The synthesis of exemestane Aromasin, an irreversible steroidal aromatase inhibitor, specifically labelled with (13)C is reported. The preparation of [(13)C(3)]exemestane was achieved according to an eight-step procedure starting from the commercially available testosterone.
Fontana
Erminia
E
Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano (MI), Italy. erminia.fontana@nervianoms.com
Pignatti
Alberto
A
Giribone
Danilo
D
Di Salle
Enrico
E
D000730:Androstadienes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002247:Carbon Isotopes; D007553:Isotope Labeling / Q000379:methods*; D013739:Testosterone / Q000737:chemistry
D000730:Androstadienes; D002247:Carbon Isotopes; D013739:Testosterone; C056516:exemestane