Ketorolac tromethamine 0.4% as a treatment for allergic conjuctivitis.
BACKGROUND
Acular LS (ketorolac tromethamine 0.4%) ophthalmic solution, a reformulation of the original Acular (ketorolac tromethamine 0.5%), is indicated for the reduction of ocular pain and burning/stinging following corneal refractive surgery.


OBJECTIVE
This manuscript will review the off-label application of this topical NSAID medication as a treatment for allergic conjunctivitis.


METHODS
An extensive MedLine search was undertaken to evaluate data on the use of ketorolac for allergic conjunctivitis. Data on both human and animal data were reviewed.


CONCLUSIONS
Studies have demonstrated that ketorolac 0.4% has equivalent efficacy to ketorolac 0.5%. Several studies have demonstrated that ketorolac effectively treats allergic conjunctivitis. Ketorolac 0.4% is effective when used as either monotherapy or as adjunct therapy to steroids.
Schechter
Barry A
BA
Florida Eye Microsurgical Institute, 1717 W Woolbright Road, Boynton Beach, FL 33426, USA. BDSCH77@aol.com
D018926:Anti-Allergic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000378:metabolism; D015352:Dry Eye Syndromes / Q000188:drug therapy; D006801:Humans; D020911:Ketorolac Tromethamine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D020911:Ketorolac Tromethamine