Pregnancy outcome in women with psoriasis.
OBJECTIVE
To determine pregnancy outcome in women with psoriasis.


METHODS
A case-control study of 145 deliveries in women with psoriasis during the years 1988-2004 was performed. For every birth, 6 births to nonpsoriatic women (n=860) were randomly selected and adjusted for ethnicity and year of delivery.


RESULTS
Recurrent abortions (OR = 2.1, 95% CI 1.1-4.9, p = 0.04) and chronic hypertension (OR = 2.9, 95% CI 1.01-8.3, p= 0.048) were significantly associated with psoriasis in a multivariable analysis with backward elimination. Psoriasis was also found as an independent risk factor for cesarean delivery (CD) in another multivariable analysis with CD as the outcome variable (OR = 4.1, 95% CI 2.3-7.5, p < 0.001).


CONCLUSIONS
A significant association exists between psoriasis and pregnancy complications. Moreover, psoriasis is an independent risk factor for CD. Thus, physicians should keep in mind that psoriasis might have nondermatologic implications that may adversely affect pregnancy.
Ben-David
Gila
G
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Sheiner
Eyal
E
Hallak
Mordechai
M
Levy
Amalia
A
D000328:Adult; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011565:Psoriasis / Q000150:complications* / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors