title: Desmocollin expression in oral atrophic lichen planus correlates with clinical behavior and DNA content.
abstract: BACKGROUND
  Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, with some tendency toward malignant transformation. Markers are needed to identify the lesions at risk.
  
  
  METHODS
  A series of 82 biopsies from 70 patients with atrophic OLP was analyzed for desmocollin-1, E-cadherin, cyclin-dependent kinase 1 (cdk-1) and Rad-51 expression using immunohistochemistry and static DNA cytometry, with particular reference to clinical outcome.
  
  
  RESULTS
  Desmocollin-1 and E-cadherin expression were each detected in 24.4% (20/82) of the samples. Of the positive samples, only eight specimens expressed both desmocollin-1 and E-cadherin. Strong desmocollin-1 and E-cadherin expression was found in 8.5% and 3.7% of OLP biopsies, respectively. Desmocollin-1 expression increased the risk of dysplasia 31.8-fold (95% confidence intervals (CI) 3.6-280.9; p = 0.0001), while E-cadherin was significantly related to cancer (odds ratio (OR) = 5.13; 95% CI 3.3-8.1; p = 0.001). In univariate survival analysis, desmocollin-1 was a significant predictor of both cancer (log-rank test; p = 0.033) and dysplasia (p = 0.0001), while E-cadherin predicted the development of cancer (p = 0.0001). Neither cdk-1 nor Rad-51 had any predictive value. Importantly, desmocollin-1 retained its value as the only independent predictor of dysplasia in the multivariate (Cox) model (adjusted Hazard Ratio (HR) = 44.13; 95% CI 3.7-525.6).
  
  
  CONCLUSIONS
  In atrophic OLP, desmocollin-1 is a powerful predictor of an important intermediate endpoint marker (dysplasia) in the causal pathway toward oral cancer.
authors.affiliation: Department of Oral Pathology and Radiology, Institute of Dentistry, University of Turku, Turku, Finland. riikka.mattila@utu.fi
authors.forename: Riikka
authors.initials: R
authors.lastname: Mattila
authors.forename: Kalle
authors.initials: K
authors.lastname: Alanen
authors.forename: Stina
authors.initials: S
authors.lastname: Syrjänen
mesh_terms: D000328:Adult; D000368:Aged; D000782:Aneuploidy; D001284:Atrophy; D015415:Biomarkers / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D049109:Cell Proliferation; D004247:DNA / Q000032:analysis; D051187:Desmocollins / Q000378:metabolism*; D005260:Female; D006801:Humans; D019044:Image Cytometry; D007150:Immunohistochemistry; D017676:Lichen Planus, Oral / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015820:Cadherins; C081560:DSC1 protein, human; D051187:Desmocollins; D004247:DNA