title: Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
authors.affiliation: Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA. mccubreyj@ecu.edu
authors.forename: James A
authors.initials: JA
authors.lastname: McCubrey
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Sokolosky
authors.forename: Brian D
authors.initials: BD
authors.lastname: Lehmann
authors.forename: Jackson R
authors.initials: JR
authors.lastname: Taylor
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Navolanic
authors.forename: William H
authors.initials: WH
authors.lastname: Chappell
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Abrams
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Stadelman
authors.forename: Ellis W T
authors.initials: EW
authors.lastname: Wong
authors.forename: Negin
authors.initials: N
authors.lastname: Misaghian
authors.forename: Stefan
authors.initials: S
authors.lastname: Horn
authors.forename: Jörg
authors.initials: J
authors.lastname: Bäsecke
authors.forename: Massimo
authors.initials: M
authors.lastname: Libra
authors.forename: Franca
authors.initials: F
authors.lastname: Stivala
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ligresti
authors.forename: Agostino
authors.initials: A
authors.lastname: Tafuri
authors.forename: Michele
authors.initials: M
authors.lastname: Milella
authors.forename: Marek
authors.initials: M
authors.lastname: Zarzycki
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dzugaj
authors.forename: Francesca
authors.initials: F
authors.lastname: Chiarini
authors.forename: Camilla
authors.initials: C
authors.lastname: Evangelisti
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Martelli
authors.forename: David M
authors.initials: DM
authors.lastname: Terrian
authors.forename: Richard A
authors.initials: RA
authors.lastname: Franklin
authors.forename: Linda S
authors.initials: LS
authors.lastname: Steelman
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D005260:Female; D006801:Humans; D053858:Metabolic Networks and Pathways; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D011494:Protein Kinases / Q000187:drug effects / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D058570:TOR Serine-Threonine Kinases; D014407:Tumor Cells, Cultured; D048490:raf Kinases / Q000502:physiology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004317:Doxorubicin; D048049:Extracellular Signal-Regulated MAP Kinases; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; D048490:raf Kinases; C546842:MTOR protein, human; C494929:PTEN protein, human