The tail of mycolic acids.
The FabH enzyme from M. tuberculosis binds the acyl tail of large substrates at the end of a buried hydrophobic tunnel. Sachdeva et al. (2008) use reactive chemical probes and X-ray crystallography to show that substrates can bind to an open state of FabH without threading through the tunnel.
Lu
Jeff Zhiqiang
JZ
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Prigge
Sean T
ST
D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D001665:Binding Sites; D003545:Cysteine / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D009171:Mycolic Acids / Q000378:metabolism*; D011485:Protein Binding
D008024:Ligands; D009171:Mycolic Acids; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; D003545:Cysteine