The functions of Deoxyribonuclease II in immunity and development.
Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made to identify these nucleases that are responsible for these effects. In contrast to Deoxyribonuclease I (DNase I), Deoxyribonuclease II (DNase II) has been less well characterized in these processes. Additionally, enzymes of DNase II family in Trichinella spiralis, which is an intracellular parasitic nematode, are also considered involved in the development of the nematode. We have compiled information from studies on DNase II from various organisms and found some nonclassic features in these enzymes of T. spiralis. Here we have reviewed the characterization and functions of DNase II in these processes and predicted the functions of these enzymes in T. spiralis during host invasion and development.
Liu
Ma-feng
MF
Key Laboratory of Zoonosis, Institute of Zoonosis, Jilin University, Ministry of Education, Changchun, P. R. China.
Wu
Xiu-ping
XP
Wang
Xue-lin
XL
Yu
Yan-ling
YL
Wang
Wei-fang
WF
Chen
Qi-jun
QJ
Boireau
Pascal
P
Liu
Ming-yuan
MY
D000818:Animals; D049109:Cell Proliferation; D004706:Endodeoxyribonucleases / Q000502:physiology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D017160:Trichinella spiralis / Q000201:enzymology / Q000472:pathogenicity
D004706:Endodeoxyribonucleases; C019329:deoxyribonuclease II