title: Overview of mouse assays of ethanol intoxication.
abstract: There are many behavioral assays to assess sensitivity to ethanol intoxication in mice. Most are simple to implement, and are sensitive to a particular dose range of ethanol. Most reflect genetic influences, and each test appears to reflect the contribution of a relatively distinct collection of genes. This genetic heterogeneity implies that no single test can claim to capture the construct "ethanol intoxication" completely. Depending on the test, and when measurements are made, acute functional tolerance to even a single dose of ethanol must be considered as a contributing factor. Whether or not a test is conducted in naïve mice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several.
authors.affiliation: Portland VA Medical Center, Portland, Oregon, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Crabbe
authors.forename: Andy J
authors.initials: AJ
authors.lastname: Cameron
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Munn
authors.forename: Mark
authors.initials: M
authors.lastname: Bunning
authors.forename: Douglas
authors.initials: D
authors.lastname: Wahlsten
mesh_terms: D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000633:toxicity*; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D051379:Mice
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol