Hierarchically mesoporous-macroporous bioactive glasses scaffolds for bone tissue regeneration.
Hierarchically 2D/3D mesoporous-macroporous bioactive glasses (MMBG) with good molding capabilities and compressive modulus were synthesized by sol-gel method and evaporation-induced self-assembly process in the presence of both nonionic triblock copolymers, EO(70)PO(20)EO(70) (P123) or EO(100)PO(65)EO(100) (F127), templates and methyl cellulose template. P123 or F127 acts as both a template, inducing the formation of mesopore, and an effective dispersant of MC, which produces macropores. In vitro bioactivity studies were carried out in simulated body fluid and showed superior bone-forming bioactivities of hierarchical MMBG. Human osteoblastlike cells, MG63, were seeded on MMBG and were determined using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5,-diphenyl-tetrazolium bromide] assay to confirm biocompatibilities of MMBG.
Yun
Hui-suk
HS
Center for Future Technology, Korea Institute of Materials Science, Changwon, Gyeongnam, South Korea 641-83. yuni@kims.re.kr
Kim
Seung-eon
SE
Hyun
Yong-taek
YT
Heo
Su-jin
SJ
Shin
Jung-wook
JW
D017209:Apoptosis; D001861:Bone Regeneration; D002460:Cell Line; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D023822:Tissue Engineering; D014961:X-Ray Diffraction