title: Reversible posterior leukoencephalopathy syndrome: a possible manifestation of Wegener's granulomatosis-mediated endothelial injury.
abstract: We present the case of a 15-year-old girl who had Wegener's granulomatosis with severe intestinal involvement. During the clinical course, she developed generalized seizures and was diagnosed with reversible posterior leukoencephalopathy syndrome (RPLS). Plasma exchange combined with steroid pulse therapy was initiated and showed marked improvement. This is one of the few cases of RPLS without severe hypertension or renal failure, suggesting that RPLS is likely to be a manifestation of Wegener's granulomatosis-mediated endothelial injury.
authors.affiliation: Department of Internal Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima-ku, Osaka, Japan. chaby_john@yahoo.co.jp
authors.forename: Minako
authors.initials: M
authors.lastname: Nishio
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamagami
authors.forename: Takashi
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Konishi
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Kimihide
authors.initials: K
authors.lastname: Himuro
authors.forename: Masahito
authors.initials: M
authors.lastname: Imanishi
mesh_terms: D000293:Adolescent; D004727:Endothelium / Q000473:pathology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010951:Plasma Exchange; D054038:Posterior Leukoencephalopathy Syndrome / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D020551:Pulse Therapy, Drug; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids