Centromeres in cell division, evolution, nuclear organization and disease.
As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.
Gonçalves Dos Santos Silva
Amanda
A
Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.
Sarkar
Rahul
R
Harizanova
Jana
J
Guffei
Amanda
A
Mowat
Michael
M
Garini
Yuval
Y
Mai
Sabine
S
D005075:Biological Evolution; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism*; D002503:Centromere / Q000378:metabolism*; D004194:Disease; D006801:Humans; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000473:pathology