title: RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder.
abstract: We studied the association between RGS4 (rs951436) polymorphism and treatment response in electroconvulsive therapy (ECT) as well as risk of treatment-resistant depression. The study sample consisted of 119 patients with major depressive disorder (MDD) and 384 healthy control subjects. RGS4 polymorphism was not associated with treatment response in ECT or risk of MDD. According to the present data, the impact of RGS4 genotype is not decisive in major depressive disorder. The results provide preliminary data on the impact of RGS4 polymorphism in treatment response in ECT.
authors.affiliation: University of Tampere, Medical School, Department of Psychiatry, Tampere University Hospital, Tampere, Finland. kaija.huuhka@pshp.fi
authors.forename: Kaija
authors.initials: K
authors.lastname: Huuhka
authors.forename: Olli
authors.initials: O
authors.lastname: Kampman
authors.forename: Sami
authors.initials: S
authors.lastname: Anttila
authors.forename: Martti
authors.initials: M
authors.lastname: Huuhka
authors.forename: Riikka
authors.initials: R
authors.lastname: Rontu
authors.forename: Kari M
authors.initials: KM
authors.lastname: Mattila
authors.forename: Mikko
authors.initials: M
authors.lastname: Hurme
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Esa
authors.initials: E
authors.lastname: Leinonen
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000235:genetics* / Q000628:therapy*; D004351:Drug Resistance; D004565:Electroconvulsive Therapy; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D020710:RGS Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D020121:5' Untranslated Regions; D000928:Antidepressive Agents; D020710:RGS Proteins; C098799:RGS4 protein