[Study of the relationship between obstructive sleep apnea syndrome and obesity and serum resistin level].
OBJECTIVE
To investigate the serum resistin level in healthy volunteers and patients with obstructive sleep apnea syndrome (OSAHS), and study the relationship between OSAHS and obesity, serum resistin level.


METHODS
All body's height, weight and calculate body mass index (BMI) were precisely measured. According to the BMI, 35 OSAHS patient were divided into two groups: One group was normal weight patients (BMI:18.5-24.9, 14 cases)and the other group was overweight patients(BMI > or =25, 21 cases). There were 40 healthy volunteers in control group. The blood pressure, fasting levels of plasma glucose (FPG), total cholesterol (TC) and triglyceride (TG), and test resistin level in plasma were detected. The apnea-hypopnea index (AHI), the average oxygen saturation and the minimum oxygen saturation in 35 OSAHS patients were examined with Polysomnography.


RESULTS
(1) Compared with healthy volunteers, serum resistin level, BMI, TG, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in OSAHS patients were all enhanced (P < 0.05); (2) In OSAHS patients, the indexes of BMI, SBP, DBP and AHI for overweight group were notably higher than those for normal weight group (P < 0.05). (3) In OSAHS patients, BMI was positively correlated with AHI and SBP, and negatively correlated with the average oxygen saturation and the minimum oxygen saturation. (4) Serum resistin level was positively correlated with TG, FPG and DBP. Multiple stepwise regression analysis revealed that serum resistin level was associated with TG and FPG.


CONCLUSIONS
In OSAHS patients, serum resistin level is enhanced and accompany with the disorder of blood pressure and serum lipid. Obesity or abdomen obesity may aggravate the hypoxia in OSAHS patients. Serum resistin level is positively correlated with TG, FPG and DBP. TG and FPG are important factors in serum resistin level, which indicate that the resistin is highly associated with lipid metabolism and glycometabolism, and possibly connect with diastolic blood pressure (DBP).
Zheng
Mingxiu
M
Department of Otorhinolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming, 650101, China. miqingyun_000@126.com
Wang
Mei
M
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010101:Oxygen Consumption; D017286:Polysomnography; D052243:Resistin / Q000097:blood*; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D008055:Lipids; C499624:RETN protein, human; D052243:Resistin; D014280:Triglycerides; D002784:Cholesterol