Association of fibrinogen and fibrinogen gene beta148 and beta854 polymorphisms with coronary heart disease.
BACKGROUND
The aim of this study was to observe the association between fibrinogen C148T, G854A polymorphisms and plasma fibrinogen levels in a large cohort of Chinese patients with coronary heart disease (CHD).


METHODS
Fibrinogen gene beta148/beta854 polymorphisms were screened and plasma fibrinogen levels and lipids were measured in patients with angiographically confirmed CHD (n = 836) and in controls without CHD (n = 418).


RESULTS
Age, sex, smoking, hypertension, diabetes mellitus, blood lipids and fibrinogen levels were related to CHD (all p < 0. 05) while the frequencies of fibrinogen beta148 and beta854 alleles, gene and genotypes between the two groups were similar (all p > 0.05).


CONCLUSIONS
This study demonstrates that the plasma fibrinogen level, but not fibrinogen beta148 and beta854 genotypes, was associated with CHD in the Chinese population.
Sun
Ai-jun
AJ
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Ma
Hui-li
HL
Chen
Xue-ying
XY
Wang
Ying
Y
Fang
Ye-ming
YM
Ma
Yong-li
YL
Wang
Ke-qiang
KQ
Zou
Yun-zeng
YZ
Huang
Wei
W
Ge
Jun-bo
JB
D000368:Aged; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017678:Sex Distribution
D005340:Fibrinogen