title: From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome.
abstract: The H1 haplotype was first identified 10 years ago. Initially, a dinucleotide polymorphism was detected in the tau (MAPT) gene and was subsequently found to be in linkage disequilibrium (LD) with other polymorphisms, forming the MAPT H1 haplotype, a risk factor for many neurological diseases, considered as tauopathies. Genetic and histopathologic data are in agreement that MAPT and its encoded protein have a pivotal role in the normal function of neurons. Currently, the H1 haplotype extends beyond the outer edges of MAPT encompassing multiple genes on chromosome 17 and thus increasing the number of candidate genes implicated in the pathogenesis of tauopathies. This review highlights the milestones and basic events in the journey towards uncovering the significance of the H1 haplotype.
authors.affiliation: Department of General Biology, Medical School, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
authors.forename: Kallirhoe
authors.initials: K
authors.lastname: Kalinderi
authors.forename: Liana
authors.initials: L
authors.lastname: Fidani
authors.forename: Sevasti
authors.initials: S
authors.lastname: Bostantjopoulou
mesh_terms: D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000266:history*; D016875:tau Proteins / Q000235:genetics
chemical_list: D016875:tau Proteins