title: Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
abstract: OBJECTIVE
  To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy.
  
  
  METHODS
  Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system.
  
  
  RESULTS
  PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis.
  
  
  CONCLUSIONS
  PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment.
authors.affiliation: Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, via Cadore 48, 20052 Monza (MI), Italy. gloria.galimberti@unimib.it
authors.forename: Gloria
authors.initials: G
authors.lastname: Galimberti
authors.forename: Elisa
authors.initials: E
authors.lastname: Conti
authors.forename: Michela
authors.initials: M
authors.lastname: Zini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Piazza
authors.forename: Francesco
authors.initials: F
authors.lastname: Fenaroli
authors.forename: Valeria
authors.initials: V
authors.lastname: Isella
authors.forename: Maurizio
authors.initials: M
authors.lastname: Facheris
authors.forename: Vittoria
authors.initials: V
authors.lastname: Perlangeli
authors.forename: Laura
authors.initials: L
authors.lastname: Antolini
authors.forename: Francesco
authors.initials: F
authors.lastname: DeFilippi
authors.forename: Carlo
authors.initials: C
authors.lastname: Ferrarese
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008715:Methionine / Q000008:administration & dosage* / Q000097:blood; D012680:Sensitivity and Specificity
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D008715:Methionine