Bioinformatics and transcriptomics studies of early implantation.
Little is known of the genes that mediate cell interactions at implantation. A combined transcriptomics/bioinformatics protocol is described that identifies cell surface glycoproteins in endometrium with potential involvement in implantation. This is linked to an in vitro model in which functional assays of candidate gene products can be carried out.
Aplin
John D
JD
Maternal and Fetal Health Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 0JH, UK. john.aplin@manchester.ac.uk
Singh
Harmeet
H
D000818:Animals; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods*; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D054794:Glycomics / Q000379:methods; D016695:Glycosyltransferases / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D014158:Transcription, Genetic
D016695:Glycosyltransferases