title: Recent advances in RNA structure determination by NMR.
abstract: Despite recent advances in the solution of NMR structures of RNA and RNA-ligand complexes, the rate limiting step remains the gathering of a large number of NOE and torsion restraints. Additional sources of information for structure determination of larger RNA molecules have recently become available, and it is possible to supplement NOE and J-coupling data with the measurement of dipolar couplings and cross-correlated relaxation rates in high-resolution NMR spectroscopy.
authors.affiliation: The Scripps Research Institute, La Jolla, California, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hennig
authors.forename: J R
authors.initials: JR
authors.lastname: Williamson
authors.forename: A S
authors.initials: AS
authors.lastname: Brodsky
authors.forename: J L
authors.initials: JL
authors.lastname: Battiste
mesh_terms: D001483:Base Sequence; D006860:Hydrogen Bonding; D007553:Isotope Labeling; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics
chemical_list: D012313:RNA