title: Proinflammatory cytokines in cerebrospinal fluid from patients with nontyphoidal Salmonella encephalopathy.
abstract: Nontyphoidal Salmonella (NTS) encephalopathy is characterized by rapidly progressive brain dysfunction that develops after NTS enteritis. The mechanism of central nervous system involvement remains unclear. We examined cerebrospinal fluids from 7 patients for cytokines and found elevated interleukin-6, interleukin-8, and monocyte chemotactic protein-1 concentrations in all the patients, suggesting that the proinflammatory cytokines are involved in the pathogenesis of NTS encephalopathy.
authors.affiliation: Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima Seikyo Hospital, Kagoshima, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Imamura
authors.forename: Junichiro
authors.initials: J
authors.lastname: Nishi
authors.forename: Izumi
authors.initials: I
authors.lastname: Tamada
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tenokuchi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Toyoshima
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D001927:Brain Diseases / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000134:cerebrospinal fluid*; D004751:Enteritis / Q000150:complications*; D006801:Humans; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D012480:Salmonella Infections / Q000150:complications*
chemical_list: D018932:Chemokine CCL2; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8