title: Palmoplantar keratoderma and skin grafting: postsurgical long-term follow-up of two cases with Olmsted syndrome.
abstract: Olmsted syndrome is a rare congenital mutilating palmoplantar keratoderma associated with periorificial keratotic plaques. Treatment options include topical keratolytics, systemic retinoids, and debulking procedures. Full-thickness excision of hyperkeratotic plaques followed by skin grafting has been reported in the medical literature, although long-term results have not been evaluated. We present two cases of Olmsted syndrome with severe palmoplantar keratoderma treated with excision and skin grafting, along with long-term clinical results 11 years (patient 1) and 6 years (patient 2) following the initial surgery.
authors.affiliation: Dermatology Program, Laval University, Québec City, Québec, Canada.
authors.forename: Marie-Sophie
authors.initials: MS
authors.lastname: Bédard
authors.forename: Julie
authors.initials: J
authors.lastname: Powell
authors.forename: Louise
authors.initials: L
authors.lastname: Laberge
authors.forename: Claire
authors.initials: C
authors.lastname: Allard-Dansereau
authors.forename: Patricia
authors.initials: P
authors.lastname: Bortoluzzi
authors.forename: Danielle
authors.initials: D
authors.lastname: Marcoux
mesh_terms: D000015:Abnormalities, Multiple; D017255:Acitretin / Q000627:therapeutic use; D000671:Amputation, Surgical; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007645:Keratoderma, Palmoplantar / Q000151:congenital* / Q000175:diagnosis / Q000601:surgery*; D007641:Keratolytic Agents / Q000627:therapeutic use; D053685:Laser Therapy; D010032:Otitis Externa / Q000175:diagnosis; D012008:Recurrence; D012086:Reoperation; D016038:Skin Transplantation; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin