Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.
OBJECTIVE
To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication.


METHODS
Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy.


METHODS
Change in 11C-PiB uptake.


RESULTS
Uptake of 11C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased 11C-PiB uptake was different from that seen in sporadic Alzheimer disease.


CONCLUSIONS
Amyloid imaging with 11C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of 11C-PiB accumulation differs between patients with typical AD and patients with APP locus duplication.
Remes
Anne M
AM
Clinical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland. anne.remes@oulu.fi
Laru
Lauri
L
Tuominen
Hannu
H
Aalto
Sargo
S
Kemppainen
Nina
N
Mononen
Helinä
H
Någren
Kjell
K
Parkkola
Riitta
R
Rinne
Juha O
JO
D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D002421:Caudate Nucleus / Q000000981:diagnostic imaging; D028243:Cerebral Amyloid Angiopathy, Familial / Q000000981:diagnostic imaging* / Q000235:genetics; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D020440:Gene Duplication; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D058255:Protease Nexins; D011699:Putamen / Q000000981:diagnostic imaging; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D012680:Sensitivity and Specificity; D013702:Temporal Lobe / Q000000981:diagnostic imaging; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D013844:Thiazoles