title: Transient directional disorientation as a manifestation of cerebral ischemia.
abstract: The authors describe 2 patients who presented with transient directional disorientation (TDD) as a manifestation of cerebral ischemia. The patients suddenly lost sense of direction in a familiar environment despite preserved ability to recognize landmarks, and recovered within a short time. Brain MRI revealed an ischemic lesion in the right medial occipital lobe and the corpus callosum in case 1 and in the right parieto-occipital sulcus (POS) in case 2. After ictus, fMRI study of a navigation task was performed, which demonstrated the activation of the POS unilaterally in case 1 and bilaterally in case 2. We propose that TDD of our patients is related to temporary dysfunction of bilateral POS.
authors.affiliation: Department of Neurology, Rakuwakai-Otowa Hospital, Kyoto, Japan. rakuwadr042@rakuwadr.com
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ino
authors.forename: Hideo
authors.initials: H
authors.lastname: Usami
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tokumoto
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ozawa
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D001364:Awareness; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D048909:Diabetes Complications / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D020300:Intracranial Hemorrhages / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging; D008297:Male; D009949:Orientation; D021641:Recognition, Psychology; D013028:Space Perception; D013037:Spatial Behavior