title: Toll-like receptors.
abstract: This has led to the identification of several important roles for Toll receptors in mammals. This unit discusses mammalian Toll receptors (TLR1-10) that have an essential role in the innate immune recognition of microorganisms. Also discussed are TLR-mediated signaling pathways and antibodies that are available to detect specific TLRs.
authors.affiliation: Osaka University, Osaka, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takeda
authors.affiliation: Osaka University and ERATO Japan Science and Technology Agency, Osaka, Japan.
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000918:Antibody Specificity; D001424:Bacterial Infections / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics; D053472:Nod Signaling Adaptor Proteins / Q000235:genetics; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014764:Viral Proteins / Q000276:immunology
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D053594:Myeloid Differentiation Factor 88; D053472:Nod Signaling Adaptor Proteins; C470409:TICAM1 protein, human; D051193:Toll-Like Receptors; D014764:Viral Proteins