title: A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
abstract: The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Baumann
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Nikzad
authors.initials: N
authors.lastname: Nikbin
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Smith
authors.forename: Jason P
authors.initials: JP
authors.lastname: Tierney
mesh_terms: D001386:Azides / Q000737:chemistry*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001386:Azides; D002219:Carbamates; D002264:Carboxylic Acids; D014508:Urea; C007523:diphenylphosphorazidate