title: Pregnancy and parturition of mice latently infected with Pseudorabies virus.
abstract: In this study, the influence of pregnancy and parturition on mice in a mouse model of latent infection with Pseudorabies virus (PrV) was analyzed. Latently infected (LI) female mice were paired with mature uninfected males. The mating produced progeny without any clinical signs of Aujeszky's Disease. At weaning, both male and female progeny of LI mice showed significantly lower weight than control mice. PrV was not detected from nasal swab specimens of the female parent mice or the trigeminal ganglia of all mice, except 3 of 50 neonatal mice. These findings demonstrate that pregnancy and parturition induce little reactivation of latent PrV, but do affect the mother's body, as indicated by the decreased weight of progeny at weaning.
authors.affiliation: Division of Laboratory Animal Sciences, Department of Life Science, Institute of Scientific Research, Oita University, Hasama-machi, Yufu, Oita, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mannen
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000821:virology; D000914:Antibodies, Viral; D001835:Body Weight; D005260:Female; D011558:Herpesvirus 1, Suid / Q000276:immunology / Q000502:physiology*; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008807:Mice, Inbred BALB C; D036801:Parturition / Q000276:immunology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D011557:Pseudorabies / Q000276:immunology* / Q000821:virology*; D014775:Virus Activation; D017735:Virus Latency; D014886:Weaning
chemical_list: D000914:Antibodies, Viral