Nonpeptidic vinyl and allyl phosphonates as falcipain-2 inhibitors.
Ettari
Roberta
R
Dipartimento Farmaco Chimico, University of Messina, Viale Annunziata, 98168 Messina, Italy. rettari@pharma.unime.it
Nizi
Emanuela
E
Di Francesco
Maria Emilia
ME
Micale
Nicola
N
Grasso
Silvana
S
Zappalà
Maria
M
Vicík
Radim
R
Schirmeister
Tanja
T
D000818:Animals; D001569:Benzodiazepines / Q000737:chemistry; D003546:Cysteine Endopeptidases / Q000187:drug effects* / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D008956:Models, Chemical; D063065:Organophosphonates / Q000138:chemical synthesis / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology*
D015853:Cysteine Proteinase Inhibitors; D063065:Organophosphonates; D013450:Sulfones; D001569:Benzodiazepines; C009873:divinyl sulfone; D003546:Cysteine Endopeptidases; C416224:falcipain 2