Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory.
Previous studies have shown that medial prefrontal cortical regions, such as the anterior cingulate cortex (ACC), play a key role in the expression of remote spatial and contextual memory. To evaluate whether this role is conserved in hippocampal-independent tasks we trained mice in the conditioned taste aversion (CTA) paradigm. Lidocaine-induced inactivation of the ACC blocked the expression of CTA tested one month (remote), but not one day (recent), after conditioning with either a weak or strong unconditioned stimulus (US). These data suggest that the ACC may play a conserved role in remote memory, regardless of memory strength or content.
Ding
Hoi Ki
HK
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto M5G 1X8, Canada.
Teixeira
Cátia M
CM
Frankland
Paul W
PW
D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D006179:Gyrus Cinguli / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D008568:Memory; D051379:Mice; D013649:Taste
D000779:Anesthetics, Local; D008012:Lidocaine