title: Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols.
abstract: A convenient BF(3).Et(2)O-catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1(H)-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction.
authors.affiliation: Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, Shanghai, PR China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhou
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Li
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D006847:Hydrocarbons, Iodinated; D007192:Indenes; D020005:Propanols; C006463:allyl alcohol