Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus.
Transcription is a central function occurring in the nucleus of eukaryotic cells in coordination with other nuclear processes. During transcription, the nascent pre-mRNA associates with mRNA-binding proteins and undergoes a series of processing steps, resulting in export-competent mRNA ribonucleoprotein complexes (mRNPs) that are transported into the cytoplasm. Experimental evidence increasingly indicates that the different processing steps (5'-end capping, splicing, 3'-end cleavage) and mRNP export are connected to each other as well as to transcription, both functionally and physically. Here, we review the overall process of mRNP biogenesis with particular emphasis on the functional coupling of transcription with mRNP biogenesis and export and its relationship to nuclear organization.
Luna
Rosa
R
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain.
Gaillard
Hélène
H
González-Aguilera
Cristina
C
Aguilera
Andrés
A
D002467:Cell Nucleus / Q000378:metabolism* / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*; D012261:Ribonucleoproteins / Q000096:biosynthesis*; D014157:Transcription Factors / Q000378:metabolism*
D009687:Nuclear Proteins; D012261:Ribonucleoproteins; D014157:Transcription Factors; C026452:messenger ribonucleoprotein