title: Prognostic role of immunosuppressive acidic protein in patients with esophageal cancer.
abstract: Immunosuppressive acidic protein (IAP) suppresses several immune responses in vivo and in vitro , and high preoperative IAP levels could predict the impairment of the host's immunity. In this study prognostic significance of preoperative IAP levels was investigated in 68 esophageal cancer patients with curative resection and eight with non-curative resection. The curative group had significantly lower levels than the non-curative group (432 +/- 183 mg/mL vs. 739 +/- 235 mg/mL, P < 0.0001). The IAP levels were associated with T-status (P < 0.0001), lymphatic invasion (P < 0.05), and p-stages (P < 0.0001). When 5-year survival rate of patients with curative resection was compared by setting various cutoff values of IAP between high and low IAP groups, several cutoff points (400-580 mg/mL) were revealed to be significantly associated with survival. Setting cutoff value of IAP to 560 mg/mL resulted in a most significant difference of 5-year survival rate of patients between the high and low IAP groups (13.9% and 61.5%, P < 0.0001). These data indicate that pre-operative IAP level is a useful parameter to predict the prognosis of esophageal cancer patients after curative resection.
authors.affiliation: Department of Surgery 1, Fukushima Medical University, Fukushima, Japan. kogure@fmu.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Kogure
authors.forename: S
authors.initials: S
authors.lastname: Kashimura
authors.forename: S
authors.initials: S
authors.lastname: Matsuyama
authors.forename: S
authors.initials: S
authors.lastname: Ohtani
authors.forename: Z
authors.initials: Z
authors.lastname: Saze
authors.forename: Y
authors.initials: Y
authors.lastname: Odashima
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: N
authors.initials: N
authors.lastname: Soeta
authors.forename: F
authors.initials: F
authors.lastname: Osuka
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Terashima
authors.forename: M
authors.initials: M
authors.lastname: Terashima
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D004938:Esophageal Neoplasms / Q000097:blood* / Q000401:mortality*; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein