Scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl)acetic acid.
The efficient, scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl)acetic acid in enantiomerically pure form is reported using environmentally benign conditions in 30% overall yield (6 steps) for the (S)-isomer, in 27% (7 steps) for the (R)-isomer, from cyclohexanone.
Vamos
Mitchell
M
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0343, USA.
Kobayashi
Yoshihisa
Y
D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
C530611:2-(1-hydroxy-2-oxocyclohexyl)acetic acid; D000085:Acetates; D003512:Cyclohexanones; C036468:cyclohexanone