[Effects of Fructus Psoralea and Brucea javanica on the level of IL-2 and NK cell in rats infected with Pneumocystis carinii].
SD rat model of PCP was established by subcutaneous injection with dexamethasone. The treatment groups received Fructus Psoralea (FP, 10.0 mg/kg), Brucea javanica (BJ, 1.2 mg/kg) and a mixture of the two Chinese herbs(FP 5mg/kg, BJ 0.6 mg/kg) respectively. By means of detecting the level of IL-2 in sera and NK cells in spleens, the effect of FP and BJ on the level of IL-2 and NK cells in rats with Pneumocystis carinii pneumonia (PCP) was observed, with SMZco treatment group (TMP 50 mg/kg, SMZ 250 mg/kg) and groups of infected and normal rats as controls. Compared with the infected group, the level of IL-2(526.1 +/- 5.5) pg/ml and NK cells (27.1% +/- 0.8%) significantly increased in the FP group (P < 0.01), followed by the FP/BJ combination group [(314.7 +/- 6.7) pg/ml, 22.9% +/- 0.9%) (P < 0.05)], and BJ group [(285.4 +/- 6.1) pg/ml, 20.7% +/- l.0%) (P < 0.05)]. Chinese herbs Fructus Psoralea and Brucea javanica show an immune regulatory action on the PCP rats.
Dai
Xiao-dong
XD
Department of Parasitology, Dalian Medical University, Dalian 116023, China.
Qin
Yuan-hua
YH
Zhou
Chang-hai
CH
Zheng
Li-li
LL
Shao
Wei-jun
WJ
Tao
Lin
L
Cui
Yu
Y
D000818:Animals; D032269:Brucea / Q000737:chemistry; D045744:Cell Line, Tumor; D003907:Dexamethasone; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D007376:Interleukin-2 / Q000097:blood / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008517:Phytotherapy; D016720:Pneumocystis Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D045363:Pneumocystis carinii / Q000187:drug effects* / Q000254:growth & development; D011020:Pneumonia, Pneumocystis / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D003907:Dexamethasone