Effect of propofol in altering pentylenetetrazol induced seizure threshold in rats.
The present study was undertaken to evaluate the role of propofol in altering pentylenetetrazol induced seizure threshold in rats. Total 42 Wistar rats were used to evaluate different parameters (onset of action, duration of seizure, seizure severity score and number of seizure) following propofol injection. The present results showed that there was significant reduction in the time required for onset of seizure in propofol treated groups following PTZ treatment. If treated with propofol alone (2 and 5 mg/kg), there was no significant difference as compared to controls. In seizure severity score assessment, there was no significant difference with various doses of propofol alone treated groups, but the difference was observed in propofol (2 and 5 mg/kg) treated groups following PTZ treatment. Duration of seizure also significantly increased in propofol (5 mg/kg) treated group, but at 2 mg/kg of propofol treatment, no significant difference was observed. The present results showed that propofol ameliorate seizure threshold and caused prolongation of duration of seizure. However, further study and trials are needed to confirm the present results.
Prakash
A
A
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Medhi
B
B
Puri
A
A
Saikia
B
B
D000818:Animals; D004305:Dose-Response Relationship, Drug; D010433:Pentylenetetrazole / Q000633:toxicity; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors
D010433:Pentylenetetrazole; D015742:Propofol