[Assessment of main metabolic substrates utilization during aerobic phase of physical exercises in patients with first diagnosed type 1 diabetes mellitus and in healthy persons].
The purpose of the research was to study influence of first diagnosed type 1 diabetes mellitus (FDDM-1), including metabolic consequences of diabetic ketoacidosis, on utilization of main nutritious substrates under conditions of aerobic exercise. 48 patients with FDDM-1 (15females and 33 males) and 36 healthy volunteers, composing the control group, had a protocol of bicycle ergometry test with slowly growing load. Patients with FDDM-1 were divided into 2 subgroups in line with clinical characteristic of endocrinopathy debut. Subgroup 1 consisted of 15 patients, who had diabetic precoma, subgroup 2 was composed of 33 patients who did not have diabetic ketoacidosis in onset of disease. Aerobic load in patients with FDDM-1 was realized in stable condition of the main disease subcompensation, and in 1 month under condition of FDDM-1 compensation. Lipid and carbohydrate consumption percentage was estimated by the method of indirect colorimetry. Patients with FDDM-1 in stage of subcompensation did not have metabolism transformation with dominating consumption of lipids, which was noticed in healthy persons. When increase intensity of physical exercise, the reliably higher rate of carbohydrate sources consumption for supply of muscular contractions was noticed in patients with FDDM-1, especially in subgroup 2. After FDDM-1 compensation the structure of metabolic substrates consumption in warm-up period in both subgroups of patients with FDDM-1 did not have reliable differences in comparison with control group, but all further levels of aerobic exercise were characterized by significant increase of carbohydrate sources oxidation in comparison with such oxidation in healthy persons. Patients with FDDM-1 had decreased muscular tissue ability to utilize lipids in the aerobic stage of physical exercise, which can cause decrease of tolerance to physical work as a result of disorder lipid and carbohydrate participation in motion activity.
Demidov
Iu I
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D000328:Adult; D002241:Carbohydrates / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D006304:Health Status; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology
D002241:Carbohydrates; D006003:Glycogen