title: [Tissue distribution on methyl nonyl ketone of the volatile oil from Houttyunia cordata in mice].
abstract: OBJECTIVE
  To study the tissue distribution on methyl nonyl ketone of the volatile oil from Houttuynia cordata in mice in order to provide a guidance for the clinical trial.
  
  
  METHODS
  The concentrations of the volatile oil from Houttuynia cordata in biological samples were determined by GC method.
  
  
  RESULTS
  After a single oral dose of 5.0 g/kg volatile oil from Houttuynia cordata in mice, parent drug was mainly distributed in windpipe, intesting, liver, kidney, heart, blood, spleen, lung, brain, muscle; after 7 hours, parent drug of every tissue decreased over 90%.
  
  
  CONCLUSIONS
  Parent drug mianly distributes in windpipe, intestine, liver, kidney. The experiment provides pharmacokinetic evidence for the rational administration and the further development of Houttuynia cordata.
authors.affiliation: Tianjin University of TCM, Tianjin 300193, China. kai1219@163.com
authors.forename: Xue-feng
authors.initials: XF
authors.lastname: Xiao
authors.forename: Lan
authors.initials: L
authors.lastname: Gao
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Jun-ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Qiao
authors.forename: Ya-peng
authors.initials: YP
authors.lastname: Han
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002849:Chromatography, Gas; D004947:Esophagus / Q000378:metabolism*; D005260:Female; D052859:Houttuynia / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000378:metabolism; D007659:Ketones / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D014018:Tissue Distribution
chemical_list: D007659:Ketones; D009822:Oils, Volatile; C526928:undecan-2-one