Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial.
The behavioural and psychological impact of genetic testing for lung cancer susceptibility was examined among smokers (N = 61) who were randomly allocated to a GSTM1 genetic testing group (with GSTM1-missing or GSTM1-present result) or no-test control group. The GSTM1-missing (higher risk) group reported greater motivation to quit smoking, and both genetic testing groups reported lower depression than the control group at one-week follow-up (p < .05 for all). Differences were not significant at two months follow-up. This study indicates the feasibility of much-needed research into the risks and benefits for individuals of emerging lifestyle-related genetic susceptibility tests.
Sanderson
Saskia C
SC
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, University College London, London, UK. s.sanderson@ucl.ac.uk
Humphries
Steve E
SE
Hubbart
Christina
C
Hughes
Eluned
E
Jarvis
Martin J
MJ
Wardle
Jane
J
D000328:Adult; D000339:Affect; D005240:Feasibility Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015438:Health Behavior; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008967:Molecular Biology / Q000379:methods*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D011795:Surveys and Questionnaires