title: [Cytokeratin-19 in diagnosis of bone marrow metastases in patients with breast cancer - clinical results].
abstract: A lot of information about the structure and the clinical significance of citokeratins in diagnosis of malignances has been found in literature during last years. Some questions about their significance in tumor genesis and in prognosis when tumor cells are found far from the primary tumor are cleared. Our aim was to investigate bone marrow samples from 79 women with breast cancer and to detect the presence or the absence of citokeratin positive tumor cells and their significance for the prognosis of the disease. We found that citokeratin 19 provides a good estimation for presence of tumor cells in bone marrow of patients with breast cancer. Citokeratin positive samples are a marker for worse prognosis in patients with breast cancer than citokeratin 19 negative ones.
authors.affiliation: Second Clinics of Surgery, University Hospital, Stara Zagora.
authors.forename: I
authors.initials: I
authors.lastname: Iovtchev
authors.forename: M
authors.initials: M
authors.lastname: Gŭlŭbova
authors.forename: T
authors.initials: T
authors.lastname: Vlaĭkova
authors.forename: P
authors.initials: P
authors.lastname: Vidolov
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053539:Keratin-19 / Q000032:analysis* / Q000096:biosynthesis; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D015415:Biomarkers; D053539:Keratin-19