title: The hematologic manifestations of the antiphospholipid syndrome.
abstract: Various hematological pathologies have been described in association with antiphospholipid syndrome (APS). Thrombocytopenia is frequently found in APS patients, its incidence has ranged from 22-42% in different series, it is usually moderate (>50x10(9)/L) without clinical manifestation and requires no intervention. A high percentage of patients with isolated idiopathic thrombocytopenic purpura have antiphospholipid antibodies, however the pathogenetic role and the clinical importance of these antibodies in this condition is still not clear. Other hematological manifestations reported in association with APS include: bone marrow necrosis, and various thrombotic microangiopathic syndromes such as: thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, HELLP (hemolysis, elevated liver enzymes, low platelet) syndrome, and catastrophic APS. A high index of suspicion is needed for the early recognition and treatment of these conditions.
authors.affiliation: Division of Rheumatology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Imad
authors.initials: I
authors.lastname: Uthman
authors.forename: Bertrand
authors.initials: B
authors.lastname: Godeau
authors.forename: Ali
authors.initials: A
authors.lastname: Taher
authors.forename: Munther
authors.initials: M
authors.lastname: Khamashta
mesh_terms: D000743:Anemia, Hemolytic / Q000276:immunology*; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D015994:Incidence; D015539:Platelet Activation; D010974:Platelet Aggregation; D015995:Prevalence; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology / Q000628:therapy
chemical_list: D017152:Antibodies, Antiphospholipid