How can ontologies help vector biology?
The reach of genomics has now extended to vector biology, with three mosquito genomes already sequenced and more arthropod vector genomes in the pipeline. The availability of these genomes has paved the way for high-throughput investigations on genome-wide gene expression and proteomics in vector biology. Such investigations would not have been possible without parallel progress in bioinformatics. It is now necessary to construct specific ontologies that will enable vector biologists to achieve computer-comprehensible annotation of genes and genomes, but also of various experimental, clinical and surveillance data. This will inevitably lead to the enhanced usage of such controlled vocabularies, and to an effort to develop novel ontologies, particularly in the context of disease control.
Topalis
Pantelis
P
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, PO Box 1385, Vassilika Vouton, Heraklion, Crete, Greece.
Lawson
Daniel
D
Collins
Frank H
FH
Louis
Christos
C
D000818:Animals; D019295:Computational Biology / Q000639:trends*; D009033:Culicidae / Q000235:genetics*; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D016678:Genome; D023281:Genomics / Q000639:trends*; D007303:Insect Vectors / Q000235:genetics*; D040901:Proteomics / Q000639:trends*; D049490:Systems Biology / Q000639:trends; D014158:Transcription, Genetic