title: [A pharmacoepidemiological study of antiepileptic drug consumption (1992-2004)].
abstract: BACKGROUND
  Epilepsy and the epileptic syndromes are common neurological diseases and represent an important public health problem that has given rise to marked social and healthcare concerns.
  
  
  OBJECTIVE
  To analyse the changes in the consumption of antiepileptic drugs in the Basque Country Autonomous Community over a 13 year period (1992-2004).
  
  
  METHODS
  The consumption of the N03 subgroup has been studied using data from the ECOM database of the Spanish Ministry of Health and Consumer Affairs, which records the number of drug packets dispensed on National Health Service prescription. The results are expressed as defined daily doses per 1,000 inhabitants per day (DID).
  
  
  RESULTS
  A significant increase is observed in the consumption of antiepileptic drugs over the study period (5.53-9 DID). The most widely used drugs were phenobarbital, carbamazepine, valproic acid and phenytoin and, in recent years, the extensive use of gabapentin is of particular note.
  
  
  CONCLUSIONS
  Epidemiological studies on epilepsy are difficult to perform due to a number of methodological problems which are caused fundamentally by the heterogeneity of the disease. Pharmacoepidemiological studies constitute a simple, effective, low-cost tool for estimating the prevalence of the disease, and furthermore enumerates the drugs used, thus contributing to a rational use of these drugs.
authors.affiliation: Departamento de Medicina Preventiva y Salud Pública, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Vitoria, Alava, España. eider.abasolo@.ehu.es
authors.forename: E
authors.initials: E
authors.lastname: Abasolo-Osinaga
authors.forename: L C
authors.initials: LC
authors.lastname: Abecia-Inchaurregui
authors.forename: I
authors.initials: I
authors.lastname: Etxeandia-Ikobaltzeta
authors.forename: N
authors.initials: N
authors.lastname: Burgos-Alonso
authors.forename: J
authors.initials: J
authors.lastname: García-del Pozo
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D017891:Pharmacoepidemiology
chemical_list: D000927:Anticonvulsants