title: IVF-ICSI outcome in women operated on for bilateral endometriomas.
abstract: BACKGROUND
  The influence of previous conservative surgery for endometriomas on IVF-ICSI outcome is debated. Conflicting information emerging from the literature may be consequent to the fact that endometriomas are mostly monolateral. The contralateral intact ovary may adequately supply for the reduced function of the affected one. To clarify this point, we assess IVF-ICSI outcome in women operated on for bilateral endometriomas.
  
  
  METHODS
  Women selected for IVF-ICSI cycles who previously underwent bilateral endometriomas cystectomy were matched (1:2) for age and study period with patients who did not undergo prior ovarian surgery.
  
  
  RESULTS
  Sixty-eight cases and 136 controls were recruited. Women operated on for bilateral endometriotic ovarian cysts had a higher withdrawal rate for poor response (P < 0.001). In these patients, despite the use of higher doses of gonadotrophins, the number of follicles (P = 0.006), oocytes retrieved (P = 0.024) and embryos obtained (P = 0.024) were significantly lower. The clinical pregnancy rate per started cycle in cases and controls was 7% and 19% (P = 0.037) and the delivery rate per started cycle was 4% and 17%, respectively (P = 0.013).
  
  
  CONCLUSIONS
  IVF outcome is significantly impaired in women operated on for bilateral ovarian endometriomas.
authors.affiliation: Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via M. Fanti 6, 20122 Milan, Italy.
authors.forename: Edgardo
authors.initials: E
authors.lastname: Somigliana
authors.forename: Mariangela
authors.initials: M
authors.lastname: Arnoldi
authors.forename: Laura
authors.initials: L
authors.lastname: Benaglia
authors.forename: Roberta
authors.initials: R
authors.lastname: Iemmello
authors.forename: Anna Elisa
authors.initials: AE
authors.lastname: Nicolosi
authors.forename: Guido
authors.initials: G
authors.lastname: Ragni
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome