title: Antiplasmodial activity of sesquiterpene lactone from Carpesium rosulatum in mice.
abstract: In the previous work, methanol extracts of Carpesium rosulatum (Compositae) were found to have high antiplasmodial activity against Plasmodium falciparum in vitro, this activity being largely attributable to a ineupatorolides A (I-A). In the present study, encouragingly, I-A was also found to have potential antimalarial activity in vivo when tested against Plasmodium berghei in mice. I-A (2, 5, 10 mg kg(-1) day(-1)) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation, and in established infection with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg kg(-1) day(-1)). The I-A possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
authors.affiliation: Department of Applied Life science, Kon Kuk University, Seoul, 143-701, South Korea.
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Min-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D019659:Asteraceae / Q000737:chemistry*; D002738:Chloroquine / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy* / Q000401:mortality / Q000469:parasitology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018512:Parasitemia / Q000188:drug therapy / Q000401:mortality / Q000469:parasitology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010962:Plasmodium berghei / Q000187:drug effects* / Q000254:growth & development; D052939:Schizonts / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes; C524000:ineupatorolides A; D002738:Chloroquine