title: Impact of body mass index and tobacco smoking on outcome after open appendicectomy.
abstract: BACKGROUND
  The effect of body mass index (BMI) and smoking on the risk of perforated appendix and postoperative complications in patients undergoing open appendicectomy for acute appendicitis was studied.
  
  
  METHODS
  Record linkage was used to identify 6676 male construction workers who underwent open appendicectomy for acute appendicitis between 1971 and 2004. Multivariable binomial logistic regression analyses were performed.
  
  
  RESULTS
  After adjustment for age, calendar period and BMI, smoking was significantly associated with an increased risk of perforated appendicitis (PA) (P = 0.004). The relative risk was 1.29 (95 per cent confidence interval 1.11 to 1.50) among current smokers with more than 10 pack-years of tobacco use. In patients with non-perforated appendicitis (NPA), the relative risk of overall postoperative complications was significantly associated with BMI (P < 0.001), and was 2.60 (1.71 to 3.95) in obese patients and 1.51 (1.03 to 2.22) in current smokers with more than 10 pack-years of tobacco use. In patients with PA, overweight, obesity and smoking status were not associated with an increased risk of overall postoperative complications.
  
  
  CONCLUSIONS
  Perforation due to acute appendicitis was associated with current tobacco smoking. A BMI of 27.5 kg/m(2) or more and current smoking were associated with overall postoperative complications in patients with NPA.
authors.affiliation: Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital Solna, Stockholm, Sweden. sayed-omid.sadrazodi@ki.se <sayed-omid.sadrazodi@ki.se>
authors.forename: O
authors.initials: O
authors.lastname: Sadr Azodi
authors.forename: D
authors.initials: D
authors.lastname: Lindström
authors.forename: J
authors.initials: J
authors.lastname: Adami
authors.forename: R
authors.initials: R
authors.lastname: Bellocco
authors.forename: S
authors.initials: S
authors.lastname: Linder
authors.forename: A
authors.initials: A
authors.lastname: Wladis
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001062:Appendectomy / Q000379:methods* / Q000706:statistics & numerical data; D001064:Appendicitis / Q000601:surgery*; D015992:Body Mass Index; D004812:Epidemiologic Methods; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D012907:Smoking