Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates.
We examined the ability of 206 clinical isolates of Staphylococcus aureus to lyse T cells and found differences between Agr groups. We found that the beta and delta hemolysins are involved and that methicillin-resistant S. aureus strains are less toxic than methicillin-susceptible S. aureus strains.
Collins
James
J
Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom.
Buckling
Angus
A
Massey
Ruth C
RC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000145:classification / Q000378:metabolism / Q000633:toxicity*; D001427:Bacterial Toxins / Q000378:metabolism / Q000633:toxicity*; D002461:Cell Line, Transformed; D015964:Gene Expression Regulation, Bacterial; D006460:Hemolysin Proteins / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism / Q000633:toxicity*; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D015534:Trans-Activators / Q000145:classification / Q000378:metabolism
C095698:Agr protein, Staphylococcus aureus; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D015534:Trans-Activators; C025994:delta hemolysin protein, Staphylococcus aureus; D013108:Sphingomyelin Phosphodiesterase; C029878:hlb protein, Staphylococcus aureus; D008712:Methicillin