title: Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study.
abstract: This study evaluated in vivo whether the flare-up effect of GnRH agonists can be suppressed through pretreatment with a GnRH antagonist. The classic flare-up effect caused by 3.8 mg goserelin acetate could not be suppressed through pretreatment using a single dosage of 3.24 mg cetrorelix acetate.
authors.affiliation: Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany. andreas.mueller@uk.uni-erlangen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Mueller
authors.forename: Theodoros
authors.initials: T
authors.lastname: Maltaris
authors.forename: Lothar
authors.initials: L
authors.lastname: Häberle
authors.forename: Inge
authors.initials: I
authors.lastname: Hoffmann
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.forename: Ralf
authors.initials: R
authors.lastname: Dittrich
mesh_terms: D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D017273:Goserelin / Q000627:therapeutic use*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010865:Pilot Projects; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D014189:Transsexualism / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D043373:Follicle Stimulating Hormone, Human; D006727:Hormone Antagonists; D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; C062876:cetrorelix