Insulin signaling pathways and cardiac growth.
The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.
DeBosch
Brian J
BJ
Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Muslin
Anthony J
AJ
D000818:Animals; D006321:Heart / Q000254:growth & development*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism
D007328:Insulin; D013002:Somatomedins; D011972:Receptor, Insulin