Apneusis responding to buspirone in multiple sclerosis.
Apneusis is a disturbance of respiratory rhythm characterized by severely prolonged inspiratory effort, and is caused by bilateral lesions in the dorsal pons. In humans it is most commonly caused by pontine infarction and has rarely been reported in multiple sclerosis (MS). Here we report on a patient with MS who developed episodic apneusis which responded to treatment with buspirone, a serotonin type 1A receptor agonist.
O'Sullivan
R J
RJ
Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Brown
I G
IG
Pender
M P
MP
D000328:Adult; D002065:Buspirone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000473:pathology; D011149:Pons / Q000473:pathology; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D015656:Respiratory Mechanics; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*
D017366:Serotonin Receptor Agonists; D002065:Buspirone