An efficient and practical synthesis of mandelic acid by combination of complex phase transfer catalyst and ultrasonic irradiation.
Mandelic acid was synthesized from benzaldehyde with chloroform in a 81% yield at 60 degrees C for 2 h by using triethylbenzylammonium chloride (TEBA) and poly(ethylene glycol)-800 (PEG-800) as a complex phase transfer catalyst under ultrasonic irradiation. The main advantages of this present method are that the reaction time is much shorter and the yield is higher than those of the classical method. p-Methoxymandelic acid was also obtained in a 84% yield under the same reaction conditions.
Xu
Hui
H
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China. orgxuhui@nwsuaf.edu.cn
Chen
Yang
Y
D002384:Catalysis; D002725:Chloroform / Q000737:chemistry; D007202:Indicators and Reagents; D008333:Mandelic Acids / Q000138:chemical synthesis* / Q000528:radiation effects; D011092:Polyethylene Glycols / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014465:Ultrasonics
D007202:Indicators and Reagents; D008333:Mandelic Acids; D012997:Solvents; D011092:Polyethylene Glycols; D002725:Chloroform; C037938:mandelic acid