In situ preparation of glycoconjugate hollow microspheres mimics the extracellular matrix via interfacial polymerization.
A novel chitin-graft-polyleucine microsphere with hollow construction was prepared via ring-opening polymerization initiated with chitin based on interfacial protocol. The FT-IR and (1)H NMR analysis demonstrated the conjugation with regulated graft length. The study provided a facile one-step route to obtain microsphere with glycoconjugation structure. This hybrid polysaccharide-polypeptide microsphere may give promising application in drug delivery and tissue engineering.
Wang
Jing
J
Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.
Liu
Changsheng
C
Chi
Ping
P
D040761:Biomimetic Materials / Q000737:chemistry*; D005109:Extracellular Matrix / Q000737:chemistry* / Q000648:ultrastructure; D006001:Glycoconjugates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D006001:Glycoconjugates; D011108:Polymers