Microbial transformation of oleanolic acid by Fusarium lini and alpha-glucosidase inhibitory activity of its transformed products.
The biotransformation of a pentacyclic triterpene, oleanolic acid (1), with Fusarium lini afforded two oxidative metabolites, 2alpha,3beta-dihydroxyolean-12-en-28-oic acid (2), and 2alpha,3beta,11beta-trihydroxyolean-12-en-28-oic acid (3). Metabolite 3 was found to be a new compound. The structures were characterized on the basis of spectroscopic studies. These metabolites exhibited a potent inhibition of alpha-glucosidase enzyme.
Choudhary
M Iqbal
MI
HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan. hej@cyber.net.pk
Batool
Iffat
I
Khan
Shamsun Nahar
SN
Sultana
Nighat
N
Shah
S Adnan Ali
SA
Ur-Rahman
Atta
A
D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D005670:Fusarium / Q000378:metabolism*; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D009904:Optical Rotation; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D000520:alpha-Glucosidases / Q000378:metabolism
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid; D000520:alpha-Glucosidases