title: Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression.
abstract: Gliomas are the most common and deadly tumors in the central nervous system (CNS). In the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which is normally expressed in myeloid cells and accounts for their chemotaxis and activation induced by bacterial peptides. Screening of human glioma cell lines revealed that FPR was expressed selectively in glioma cell lines with a more highly malignant phenotype. FPR expressed in glioblastoma cell lines mediates cell chemotaxis, proliferation and production of an angiogenic factor, vascular endothelial growth factor (VEGF), in response to agonists released by necrotic tumor cells. Furthermore, FPR in glioblastoma cells activates the receptor for epidermal growth factor (EGFR) by increasing the phosphorylation of a selected tyrosine residue in the intracellular tail of EGFR. Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression.
authors.affiliation: Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31-76, Frederick, MD 21702-1201, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Keqiang
authors.initials: K
authors.lastname: Chen
authors.forename: Wanghua
authors.initials: W
authors.lastname: Gong
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yingying
authors.initials: Y
authors.lastname: Le
authors.forename: Xiuwu
authors.initials: X
authors.lastname: Bian
authors.forename: Ji Ming
authors.initials: JM
authors.lastname: Wang
mesh_terms: D000818:Animals; D016543:Central Nervous System Neoplasms / Q000378:metabolism / Q000473:pathology*; D066246:ErbB Receptors / Q000819:agonists / Q000378:metabolism; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D044042:Receptors, Formyl Peptide / Q000378:metabolism*
chemical_list: D044042:Receptors, Formyl Peptide; D066246:ErbB Receptors