[Effects of intranasal budesonide on the expression of c-fos and c-myc in nasal polyps].
OBJECTIVE
To investigate the effect of intranasal glucocorticoids treatment on the expression of c-fos and c-myc nasal polyps.


METHODS
Immunohistochemistry method was used to determine c-fos and c-myc expression in nasal polyps from patients with topical steroids treatment for 10-12 weeks and untreated patients.


RESULTS
The rate of c-fos expressing cases was 15% and the rate of c-myc expressing cases was 20% in nasal polyps from topical steroid treated patients, but in untreated patients, the rate of c-fos expressing cases was 80% and the rate of c-myc expressing cases was 85%. There were significant differences between two groups (P < 0.01). The c-fos and c-myc expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients.


CONCLUSIONS
The results show that glucocorticoids may induce cell apoptosis in nasal polyps by depressing the c-fos and c-myc expression.
Lin
Hai
H
Department of Otorhinolaryngology-Head and Neck Surgery, Fuzhou General Hospital of Nanjing Command of the PLA, Fuzhou, 350025, China. linh96@163.com
Chen
Xianming
X
Zhen
Zenian
Z
Yu
Yinghao
Y
Xiong
Xisheng
X
D000328:Adult; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000188:drug therapy / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*
D005938:Glucocorticoids; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D019819:Budesonide