title: Adenocarcinoma of the gastroesophageal junction after bariatric surgery.
abstract: BACKGROUND
  The development of upper gastrointestinal malignancies after bariatric surgery has not been well characterized. Our objective was to review the experience of patients with distal esophageal cancer that was diagnosed after bariatric surgery.
  
  
  METHODS
  A retrospective review was conducted to identify patients who had undergone bariatric surgery (1999 to 2006) and who later developed high-grade dysplasia or adenocarcinoma of the distal esophagus.
  
  
  RESULTS
  Three patients (of 2,875 [0.1%]) developed esophageal cancer: 2 after Roux-en-Y gastric bypass and 1 after vertical banded gastroplasty. All three patients had complaints of reflux, and two were treated with esophagectomy. The third patient presented with invasive carcinoma and died 2 years after diagnosis.
  
  
  CONCLUSIONS
  Our findings emphasize the importance of precise endoscopic evaluation before bariatric surgery in patients with gastroesophageal reflux disease (GERD), of the necessity for continuing postsurgical surveillance in patients with known Barrett's esophagitis, and of early evaluation in patients who develop new symptoms of GERD after bariatric surgery.
authors.affiliation: Department of Surgery and Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. lgolkar@hotmail.com
authors.forename: Laleh G
authors.initials: LG
authors.lastname: Melstrom
authors.forename: David J
authors.initials: DJ
authors.lastname: Bentrem
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Salvino
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Blum
authors.forename: Mark S
authors.initials: MS
authors.lastname: Talamonti
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Printen
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000368:Aged; D050110:Bariatric Surgery; D001471:Barrett Esophagus / Q000209:etiology; D004938:Esophageal Neoplasms / Q000209:etiology*; D004943:Esophagogastric Junction; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies