[Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer].
OBJECTIVE
To observe the influences of Jianwei Yuyang (JWYY) granules on expressions of PS2 and platelet activating factor (PAF), and analyze its potential mechanism.


METHODS
76 gastric ulcer patients were final diagnosed by gastroscope. They were randomly devided into 3 groups, including JWYY group (36 cases), Ranitidine group (36 cases) and Normal group (12 cases). Detection on Biospy Specimens of gastric mucosa to obseve the change of PAF, PS2 and the contents of aninohexose and phosphatide in ulcerated gastric mucosa for Immunohischemical and Western blotting.


RESULTS
The contents of aninohexose, phosphatide of PU patients increased in JWYY group. There was significant difference between JWYY group and Ranitidine group (P < 0.01). The Immunohischemical and Western blotting methods showed that there was a linear correlation between the the contents of phosphatide, anino-hexose and the expression of PAF, PS2 in PU patients (P < 0.01).


CONCLUSIONS
JWYY granule can prevent the occurrence and relaps of ulcer and affect the hydrophobicity of gastic mucosa and strengthen the stability of myxo-gellayer by reducing the expression of PAF, elevating the expression of PS2 and effecting the contents of phosphatide and aninohexose, that may be one of the mechanisms of JWYY to heal ulcer quickly.
Huang
Guo-dong
GD
First Affiliated Hospital of Nanchang University, Nanchang 330006, China. hgddr233011@sina.com
Huang
Yuan-hua
YH
Li
Jia-bang
JB
Huang
Dao-fu
DF
Xiao
Mei-zhen
MZ
Tang
Li-jun
LJ
Li
Qian
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D015153:Blotting, Western; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*; D008517:Phytotherapy; D010972:Platelet Activating Factor / Q000378:metabolism*; D011899:Ranitidine / Q000494:pharmacology / Q000627:therapeutic use; D012008:Recurrence; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology; D055815:Young Adult
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010455:Peptides; D010972:Platelet Activating Factor; C533470:jianwei yuyang; D011899:Ranitidine