[Karyotypes and pelvic ultrasonography in children with Turner syndrome].
OBJECTIVE
To study the relationship of karyotypes and gonadal development in children with Turner syndrome.


METHODS
Fifty-one children with Turner syndrome were studied. Pelvic ultrasonography was performed on the children. Twenty healthy age-matched girls were used as control group.


RESULTS
Eleven kinds of karyotypes were detected in 51 children with Turner syndrome. Children were classified into two groups based on karyotypes: Group 1 (45,XO; n= 24) and Group 2 (karyotypes other than 45, XO; n=27). 45,XO karyotype was the most common (47.1%), followed by 46,X,i (Xq)/45, XO (21.6%), 46,XX/45, XO (7.8%) and 47,XXX/45, XO (5.9%). Pelvic ultrasonography showed a primordial uterus in 41 cases, infantile uterus in 7 cases, congenital absence of uterus and ovary in 3 cases, simple anovarism in 42 cases and ovarian dysgenesis in 6 cases. Uterine size in both Groups 1 and 2 were significantly smaller than those of the control group (P<0.05). Group 1 showed smaller size of uterus than Group 2 (P<0.05). Ovaries were not detected in all Group 1 patients.


CONCLUSIONS
The dysplasia and atrophy of ovaries and uterus exist in children with Turner syndrome. The patients with 45,XO karyotype had poorer gonadal development than those with other karyotypes.
Liang
Yan
Y
Department of Internal Medicine, Guangzhou Children,s Hospital, Guangzhou 510120, China. xiuly_2033@126.com.
Cheng
Jing
J
Cai
Yan-Na
YN
Wei
Xiao-Ping
XP
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007621:Karyotyping; D010053:Ovary / Q000000981:diagnostic imaging*; D014424:Turner Syndrome / Q000000981:diagnostic imaging* / Q000235:genetics*; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging*