Olmsted syndrome: a case report and review of literature.
We report a case of an 18-month-old boy with slightly whitened fingernails and toenails since birth. At the age of 100 days, he progressively developed bilateral palmoplantar keratoderma which resulted in painful walking and disabled grasping. Perianal keratotic plaques and perioral hyperkeratotic erythema could also be observed. Both fingernails and toenails were dystrophic. Scalp hairs were sparse, but total alopecia was no present. The histopathologic changes of the biopsy from the inner side of the right foot showed nonspecific changes, which mainly showed highly hyperkeratosis and acanthosis with slight superficial perivascular inflammatory infiltration. A clinical diagnosis of Olmsted syndrome was established according to the typical feature of the lesions, which is the presence of symmetrical palmoplantar keratoderma with periorificial keratotic plaques. We review the literature and present a summary of all reported cases to date.
Tao
Juan
J
Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Huang
Chang-Zheng
CZ
Yu
Nian-Wen
NW
Wu
Yan
Y
Liu
Ye-Qiang
YQ
Li
Yan
Y
Tian
Jin
J
Yang
Ling-Yun
LY
Zhang
Jing
J
Li
Jia-Wen
JW
Zhou
You-Wen
YW
Tu
Ya-Ting
YT
D000015:Abnormalities, Multiple / Q000473:pathology*; D005260:Female; D006201:Hair Diseases / Q000473:pathology; D006801:Humans; D007223:Infant; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D007642:Keratosis / Q000473:pathology*; D008297:Male; D009092:Mucous Membrane / Q000473:pathology*; D009260:Nail Diseases / Q000473:pathology; D012867:Skin / Q000473:pathology*; D013577:Syndrome