Direct, continuous behavioral analysis of drug action on feeding.
Analysis of rodent feeding behavior during the study of anorectic drugs reveals that contextual variables such as type of food, drug, environment, and physiological state influence food intake. Temporal changes in behavior can signal the onset of a feeding modulation process, as is the case with anorectic drugs acting on distinct neurochemical mechanisms that change temporal behavioral profiles. Comparing the effects of anorectic agents in controlled animal assays can identify potential therapeutic drugs that may influence human eating behavior. This unit specifies the materials and procedures required for continuously monitoring the Behavioral Satiety Sequence, as well as a device for continuous, automatic measurement of the mass of food consumption by the animal during behavioral monitoring called the RUEMA (Rat Universal Eating Monitor Apparatus).
Goodson
Simon
S
University of Sheffield, Sheffield, United Kingdom.
Halford
Jason
J
Blundell
John
J
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001525:Behavioral Sciences / Q000295:instrumentation / Q000379:methods*; D035843:Biomedical Research / Q000379:methods*; D004435:Eating / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009488:Neurosciences / Q000295:instrumentation / Q000379:methods*; D051381:Rats; D012528:Satiety Response / Q000187:drug effects
D001067:Appetite Depressants