title: Regulative effects of essential oil from Atractylodes lancea on delayed gastric emptying in stress-induced rats.
abstract: Gastric motor dysfunction induced by psychological stress results in many symptoms of functional dyspepsia (FD). There are a number of herbal medicines that are reported to improve gastrointestinal motor. However, the mechanisms of considerable herbal medicines are not explicit. In the present study, the effects of an essential oil (EO) extracted from Atractylodes lancea on delayed gastric emptying, gastrointestinal hormone and hypothalamic corticotropin-releasing factor (CRF) abnormalities induced by restraint stress in rats were investigated and the mechanism of the EO is also explored. Oral administration of EO for 7 days did not affect normal gastric emptying, but accelerated delayed gastric emptying induced by restraint stress in rats. The EO significantly increased the levels of motilin (MTL) and gastrin (GAS) and decreased the levels of somatostatin (SS) and CRF. The EO did not modify gastric emptying in vagotomized rats that underwent restraint stress, but antagonized delayed gastric emptying induced by intracisternal injection of CRF. These results suggest that the regulative effects of the EO on delayed gastric emptying are preformed mainly via inhibition of the release of central CRF and activation of vagal pathway, which are also involved in the release of gastrointestinal hormones such as MTL, GAS and SS.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.forename: Lian-Na
authors.initials: LN
authors.lastname: Sun
authors.forename: Bao-Kang
authors.initials: BK
authors.lastname: Huang
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Chen
authors.forename: Han-Chen
authors.initials: HC
authors.lastname: Zheng
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects*; D005755:Gastrins / Q000378:metabolism; D008297:Male; D009037:Motilin / Q000378:metabolism; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013004:Somatostatin / Q000378:metabolism; D013312:Stress, Physiological; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D005755:Gastrins; D009822:Oils, Volatile; D010938:Plant Oils; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D009037:Motilin; D003346:Corticotropin-Releasing Hormone