Liposome vectors for in vivo gene delivery.
Gene therapy with nonviral, cationic liposome-based vectors has demonstrated promising results in a variety of in vivo models and some clinical trials. In contrast to viral vectors, cationic liposome-based vectors usually induce just mild inflammatory reactions, making them suitable for repeated injections in animals. This unit describes the preparation and delivery of two liposome-based vectors Gene therapy with nonviral, cationic liposome-based vectors has demonstrated promising results in a variety of in vivo models.
Whitemore
M
M
University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Li
S
S
Huang
L
L
D000818:Animals; D002460:Cell Line; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D005826:Genetics, Medical; D006801:Humans; D008081:Liposomes; D008168:Lung; D051379:Mice; D009374:Neoplasms, Experimental / Q000628:therapy
D008081:Liposomes