title: gpDB: a database of GPCRs, G-proteins, effectors and their interactions.
abstract: gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database.
  
  
  BACKGROUND
  http://bioinformatics.biol.uoa.gr/gpDB CONTACT: shamodr@biol.uoa.gr
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens 157 01, Greece.
authors.forename: Margarita C
authors.initials: MC
authors.lastname: Theodoropoulou
authors.forename: Pantelis G
authors.initials: PG
authors.lastname: Bagos
authors.forename: Ioannis C
authors.initials: IC
authors.lastname: Spyropoulos
authors.forename: Stavros J
authors.initials: SJ
authors.lastname: Hamodrakas
mesh_terms: D000465:Algorithms; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017124:Conserved Sequence; D003628:Database Management Systems; D030562:Databases, Protein; D019204:GTP-Binding Proteins / Q000737:chemistry*; D016247:Information Storage and Retrieval / Q000379:methods*; D008969:Molecular Sequence Data; D025941:Protein Interaction Mapping / Q000379:methods*; D017434:Protein Structure, Tertiary; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods*; D014584:User-Computer Interface
chemical_list: D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins