Exaggerated thyroid stimulating hormone secretion in children exposed to the Chernobyl nuclear reactor catastrophe.
We present results of a long-term study of the morpho-functional state of the thyroid gland and of the functional capacities of the hypothalamic-hypophyseal system, as shown by thyrotropin releasing hormone stimulation, in different groups of children who suffered from the Chernobyl accident. It was shown that the thyroid gland of the children who were evacuated from the 30-km zone was damaged most severely due to the influence of radioactive iodine (131I). Living on radionuclide-polluted territories in conditions of iodine deficiency has been an additional contributory factor in the development of thyroid gland diseases. Latent functional deficiency of the hypothalamic-hypophyseal system can be one of the reasons leading to oncopathology of the thyroid gland.
Boyarskaya
O Y
OY
Scientific Centre of Radiation Medicine, Academy of Medical Science of Ukraine, Kyív, Ukraine. boyarskaya_olga@mail.ru
Kopilova
O V
OV
D047852:Chernobyl Nuclear Accident; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007455:Iodine / Q000172:deficiency*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000378:metabolism*; D013961:Thyroid Gland / Q000528:radiation effects*; D013964:Thyroid Neoplasms / Q000209:etiology / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism*
D013972:Thyrotropin; D007455:Iodine