Motor learning: the FoxP2 puzzle piece.
Mutation of the DNA-binding region of the FOXP2 protein causes an inherited language disorder. A recent study provides the first data on mice with this mutation, which exhibit deficits in motor-skill learning and abnormal properties of neural circuits that contribute to these skills.
Teramitsu
Ikuko
I
University College London, Wolfson Institute for Biomedical Research, Gower Street, London WC1E 6BT, UK.
White
Stephanie A
SA
D000818:Animals; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D051379:Mice; D009048:Motor Skills / Q000502:physiology*; D019957:Motor Skills Disorders / Q000235:genetics* / Q000503:physiopathology; D020125:Mutation, Missense; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*
D051858:Forkhead Transcription Factors; C432918:Foxp2 protein, mouse; D012097:Repressor Proteins