title: T1 signal intensity and height of the anterior pituitary in neonates: correlation with postnatal time.
abstract: OBJECTIVE
  The anterior pituitary of a term neonate is usually hyperintense on T1-weighted MR images, which may represent histologic changes of the gland due to the effect of high estrogen levels during the fetal period; however, MR findings of a preterm neonate have not been fully evaluated. The purpose of this study was to investigate whether intensity and size of the neonatal anterior pituitary on MR images obtained near term of corrected age correlates with the gestational age at birth or postnatal time.
  
  
  METHODS
  Data of 88 consecutive neonates (gestational age, 24-41 weeks; mean, 31.5 weeks) were analyzed. All of the neonates underwent MR imaging at a corrected age of 0 months +/- 4 weeks. Relative signal intensity of the anterior pituitary compared with that of the pons on T1-weighted sagittal images was calculated. Height of the pituitary was also measured. Stepwise regression analysis was performed to evaluate the effects of gestational age at birth and postnatal time on the relative signal intensity and on the pituitary height.
  
  
  RESULTS
  The relative signal intensity significantly negatively correlated with postnatal time (P = .001) but not with gestational age at birth (P = .42). Pituitary height significantly negatively correlated with postnatal time (P = .049) but not with gestational age at birth (P = .071).
  
  
  CONCLUSIONS
  A significant negative correlation exists between postnatal time and signal intensity on T1-weighted MR images of the anterior pituitary obtained near term. A nonhyperintense anterior pituitary is a normal MR finding of preterm neonates when imaged near term.
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Miki
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Yura
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Sugimura
authors.forename: K
authors.initials: K
authors.lastname: Togashi
mesh_terms: D004967:Estrogens / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000033:anatomy & histology*; D011149:Pons / Q000033:anatomy & histology; D011247:Pregnancy; D012016:Reference Values; D012189:Retrospective Studies; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D004967:Estrogens