title: Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.
abstract: A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test.
authors.affiliation: ZJU-ENS joint laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences, Zijingang Campus, Zhejiang University Hangzhou 310058, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Sheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Chunqi
authors.initials: C
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: Jingya
authors.initials: J
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Qiaojun
authors.initials: Q
authors.lastname: He
authors.forename: Yongzhou
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D008568:Memory / Q000187:drug effects; D051379:Mice; D010146:Pain / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D002800:Cholinesterase Inhibitors; D007189:Indans; C486837:aurone; C013352:indacrinone