title: Deoxyribo- and ribonucleoside H-phosphonates.
abstract: Most methods for preparing H-phosphonate monoesters suffer from variable yields and are often incompatible with common protecting groups used in oligonucleotide synthesis. This unit describes four procedures that consistently give high yields of the desired products. Taken together, they provide an arsenal of phosphonylation procedures that it compatible with most common protecting groups.
authors.affiliation: Stockholm University, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Stawinski
authors.forename: R
authors.initials: R
authors.lastname: Strömberg
mesh_terms: D001671:Biochemistry / Q000379:methods*; D003853:Deoxyribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003853:Deoxyribonucleosides; D007202:Indicators and Reagents; D063065:Organophosphonates; D012263:Ribonucleosides