Detection of different clonal EBV strains in Hodgkin lymphoma and nasopharyngeal carcinoma tissues from the same patient.
The ubiquitous herpesvirus Epstein-Barr virus (EBV) is linked to the development of several malignancies, including nasopharyngeal carcinoma (UCNT) and Hodgkin lymphoma (HL). Despite the well-known oncogenic properties of the EBV latent membrane protein 1 (LMP-1), the different oncogenic pathways involved in the pathogenesis of each disease remain unclear. This study reported, for the first time, the case of a patient with sequential development of UCNT and HL. Polymerase chain reaction was used to determine the LMP-1 gene sequence and demonstrate that the two tumours contained different clonal viral genomes, suggesting a central and specific role of EBV infection.
Rey
J
J
Department of Haematology, Pathology, Cancer Center Institute J. Paoli - I.Calmettes, Marseille, France.
Xerri
L
L
Bouabdallah
R
R
Keuppens
M
M
Brousset
P
P
Meggetto
F
F
D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006689:Hodgkin Disease / Q000235:genetics* / Q000821:virology; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000821:virology; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000821:virology; D021141:Nucleic Acid Amplification Techniques; D016133:Polymerase Chain Reaction; D014763:Viral Matrix Proteins / Q000235:genetics*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins