title: Late evaluation of silent cerebral ischemia detected by diffusion-weighted MR imaging after filter-protected carotid artery stenting.
abstract: OBJECTIVE
  Postoperative diffusion-weighted MR imaging (DWI) often discloses new lesions after carotid artery stent placement (CAS), most of them asymptomatic. Our aim was to investigate the fate of these silent ischemic lesions.
  
  
  METHODS
  We prospectively studied 110 patients undergoing protected transfemoral CAS, 98 of whom underwent DWI before and after the intervention. Patients in whom DWI disclosed silent postoperative lesions also had delayed MR imaging. Preoperative, postoperative, and delayed scans were compared.
  
  
  RESULTS
  Of the 92 patients without postoperative symptoms, DWI disclosed 33 new silent ischemic lesions in 14 patients (15.2%), 13 of whom (30 lesions) underwent delayed MR imaging after a mean follow-up of 6.2 months. In 8 of these 13 patients (61%), MR imaging disclosed 12 persistent lesions (12/30, 40%). The reversibility rate depended significantly on the location (cortical versus subcortical) and size (0-5 versus 5-10 mm) of the lesions (P < .05 by chi(2) test).
  
  
  CONCLUSIONS
  Because many silent ischemic lesions seen on postoperative DWI after CAS reverse within months, the extent of permanent CAS-related cerebral damage may be overestimated.
authors.affiliation: Department of Vascular Surgery, Ospedale Sant'Andrea, La Sapienza University of Rome, Rome, Italy. giovanni.palombo@tiscali.it
authors.forename: G
authors.initials: G
authors.lastname: Palombo
authors.forename: V
authors.initials: V
authors.lastname: Faraglia
authors.forename: N
authors.initials: N
authors.lastname: Stella
authors.forename: E
authors.initials: E
authors.lastname: Giugni
authors.forename: A
authors.initials: A
authors.lastname: Bozzao
authors.forename: M
authors.initials: M
authors.lastname: Taurino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis*; D002343:Carotid Artery, Internal / Q000473:pathology; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000628:therapy*; D002544:Cerebral Infarction / Q000175:diagnosis; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral / Q000502:physiology; D016894:Endarterectomy, Carotid; D005260:Female; D005374:Filtration / Q000295:instrumentation*; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D015607:Stents