title: Uptake of first two doses of human papillomavirus vaccine by adolescent schoolgirls in Manchester: prospective cohort study.
abstract: OBJECTIVE
  To assess the feasibility and acceptability of delivering a human papillomavirus (HPV) vaccine to adolescent girls.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  36 secondary schools in two primary care trusts in Greater Manchester, United Kingdom.
  
  
  METHODS
  2817 schoolgirls in year 8 (12 and 13 year olds).
  
  
  METHODS
  Delivery of the bivalent vaccine at 0, 1, and 6 months over one school year.
  
  
  METHODS
  Vaccine uptake for doses 1 and 2 of a three dose schedule.
  
  
  RESULTS
  Vaccine uptake was 70.6% (1989/2817) for the first dose and 68.5% (1930/2817) for the second dose. Uptake was significantly lower in schools with a higher proportion of ethnic minority girls (P<0.001 for trend) or higher proportion of girls entitled to free school meals (P=0.029 for trend). The main reason for parents' refusal of vaccination was insufficient information about the vaccine and its long term safety. Maintaining the vaccine schedule was challenging as 16.3% (dose 1) and 23.6% (dose 2) of girls missed their vaccination day and had to be offered alternative appointments. No serious adverse events were reported.
  
  
  CONCLUSIONS
  Delivery of the first two doses of HPV vaccine to adolescent schoolgirls is encouraging, but the success of the vaccination programme depends on high coverage for the third dose.
authors.affiliation: Academic Unit of Obstetrics and Gynaecology, St Mary's Hospital, University of Manchester, Manchester M13 OJH. loretta.brabin@manchester.ac.uk
authors.forename: Loretta
authors.initials: L
authors.lastname: Brabin
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Roberts
authors.forename: Rebecca
authors.initials: R
authors.lastname: Stretch
authors.forename: David
authors.initials: D
authors.lastname: Baxter
authors.forename: Gloria
authors.initials: G
authors.lastname: Chambers
authors.forename: Henry
authors.initials: H
authors.lastname: Kitchener
authors.forename: Rosemary
authors.initials: R
authors.lastname: McCann
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D003695:Delivery of Health Care; D004739:England; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012572:School Health Services; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D053918:Papillomavirus Vaccines