title: Colour M-mode tissue Doppler imaging in healthy cats and cats with hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  To determine whether decreased diastolic and systolic myocardial velocity gradient between the endocardium and the epicardium exist in the left ventricle of cats with hypertrophic cardiomyopathy.
  
  
  METHODS
  Myocardial velocity gradient and mean myocardial velocities were measured by colour M-mode tissue Doppler imaging in the left ventricular free wall of 20 normal cats and 17 cats with hypertrophic cardiomyopathy.
  
  
  RESULTS
  The peak myocardial velocity gradient (sec(-1)) during the first (E1) (5.71+/-1.75 versus 11.38+/-3.1, P<0.001) and second phase (E2) (3.09+/-1.53 versus 7.02+/-3.1, P=0.005) of early diastole and also the maximum early diastolic myocardial velocity gradient (Emax) (6.12+/-2.1 versus 10.76+/-3.2, P<0.001) were reduced in cats with hypertrophic cardiomyopathy compared with normal cats. Peak myocardial velocity gradient during early systole (Se) was lower in affected cats than in normal cats (6.26+/-2.08 versus 8.67+/-2.83, P=0.006). Affected cats had a lower peak mean myocardial velocities (mm/s) during the two isovolumic periods (IVRb and IVCb) compared with normal cats (2.97+/-6.76 versus 12.74+/-5.5 and 22.28+/-9.96 versus 38.65+/-10.1, P<0.001, respectively).
  
  
  CONCLUSIONS
  This study shows that hypertrophic cardiomyopathy cats have decreased myocardial velocity gradient during both diastole and systole and also altered myocardial motion during the two isovolumic periods. Myocardial velocity gradients recorded by colour M-mode tissue Doppler imaging can discriminate between the healthy and diseased myocardium.
authors.affiliation: Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Midlothian, EH25 9RG.
authors.forename: H
authors.initials: H
authors.lastname: Koffas
authors.forename: J
authors.initials: J
authors.lastname: Dukes-McEwan
authors.forename: B M
authors.initials: BM
authors.lastname: Corcoran
authors.forename: C M
authors.initials: CM
authors.lastname: Moran
authors.forename: A
authors.initials: A
authors.lastname: French
authors.forename: V
authors.initials: V
authors.lastname: Sboros
authors.forename: K
authors.initials: K
authors.lastname: Simpson
authors.forename: T
authors.initials: T
authors.lastname: Anderson
authors.forename: W N
authors.initials: WN
authors.lastname: McDicken
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D003971:Diastole / Q000502:physiology; D018618:Echocardiography, Doppler, Color / Q000379:methods / Q000662:veterinary*; D005260:Female; D008297:Male; D013599:Systole / Q000502:physiology