[Radioiodine therapy in thyroid autonomy: initial results and experiences].
Radioiodine therapy is an established method worldwide for treatment of hyperthyroidism.


OBJECTIVE
The author analyses the results of radioiodine therapy for treatment of functional autonomy performed in the Nuclear Medicine Department of Markusovszky Hospital between November 2005 and February 2007.


METHODS
The data of 33 patients (29 women, 4 men; age: 61.9 +/- 9.8 years) were evaluated. 23 patients with multifocal autonomy and 10 patients with unifocal autonomy were treated. Individual dosimetry was performed and the activity applied was calculated using Marinelli's formula. Patients with a complete follow-up for 6 months or more were included (mean follow-up time: 11 months).


RESULTS
Successful elimination of functional thyroid autonomy resulting in either euthyroidism or hypothyroidism occurred in 88% of patients (29/33). The frequency of normalised TSH was 79% (26/33), the rate of post-treatment hypothyroidism was 9% (3/33) and the rate of residual hyperthyroidism was 12% (4/33). Previous treatment with antithyroid drugs had no negative influence on the success rate of radioiodine therapy. In 64% of patients (21/33) the administered activity exceeded 550 MBq, the upper limit of out-patient radioiodine therapy.


CONCLUSIONS
The results of radioiodine therapy in the analysed patient group are coherent with the data of several large studies. According to the references, the success rate of 85-100% are satisfying and the incidence of hypothyroidism of 10-20% is acceptable.
Bajner
Agnes
A
Vas Megyei Markusovszky Kórház Nonprofit Zrt, Nukleáris Medicina Osztály, Szombathely. izotop@markusovszky.hu
D000368:Aged; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D006980:Hyperthyroidism / Q000532:radiotherapy*; D007037:Hypothyroidism / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013960:Thyroid Function Tests; D016896:Treatment Outcome
D007457:Iodine Radioisotopes