title: Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate.
abstract: We report a chronic myeloproliferative disease-unclassifiable (CMPD-U) patient who achieved hematological remission following imatinib mesylate (imatinib). Chromosomal and molecular analyses demonstrated no genetic abnormalities of c-abl, bcr-abl, c-kit or platelet-derived growth factor receptor (PDGFR) genes from hematopoietic cells. Although there has been one report of CMPD-U patient with chromosomal abnormalities of the PDGFR gene having complete hematologic responses upon treatment with imatinib, there have not been similar reports of patients without chromosomal abnormalities. This is the first case report of a CMPD-U patient with no chromosomal abnormalities who completely responded to treatment with imatinib.
authors.affiliation: The Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Naoko
authors.initials: N
authors.lastname: Araki
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sagawa
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Takayama
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D001549:Benzamides; D002869:Chromosome Aberrations; D002908:Chronic Disease; D016313:Genes, abl / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000188:drug therapy* / Q000235:genetics*; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D011743:Pyrimidines / Q000627:therapeutic use*; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit; D017479:Receptors, Platelet-Derived Growth Factor