A polar radical pair pathway to assemble the pyrimidinone core of the HIV integrase inhibitor raltegravir potassium.
Pye
Philip J
PJ
Department of Process Research, Merck Research Laboratories, Rahway, NJ 07065, USA. philip_pye@merck.com
Zhong
Yong-Li
YL
Jones
Gavin O
GO
Reamer
Robert A
RA
Houk
Kendall N
KN
Askin
David
D
D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium
D019428:HIV Integrase Inhibitors; D009930:Organic Chemicals; D011744:Pyrimidinones; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D011188:Potassium