The ins and outs of syntenin, a multifunctional intracellular adaptor protein.
One of the most challenging issues currently facing cell biologists is how signal specificity and compartmentalization is achieved, allowing extracellular stimulation to result in a unique and pre-defined intracellular outcome. For this to occur, intracellular components must be correctly positioned in both space and time. Adaptor molecules, which contain protein-interaction domains, are often involved in the assembly of multimeric complexes that organize intracellular signal-transduction pathways. One such protein is syntenin, a PDZ-domain-containing molecule that has a surprising variety and diversity of interaction partners. Here we assimilate and discuss current data that support a role for syntenin in regulating transmembrane-receptor trafficking, tumour-cell metastasis and neuronal-synapse function.
Beekman
Jeffrey M
JM
Department of Immunology and Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.
Coffer
Paul J
PJ
D000595:Amino Acid Sequence; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D008024:Ligands; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D053676:Syntenins / Q000737:chemistry / Q000378:metabolism*
D008024:Ligands; D011956:Receptors, Cell Surface; D053676:Syntenins