Deoxyribo- and ribonucleoside H-phosphonates.
Most methods for preparing H-phosphonate monoesters suffer from variable yields and are often incompatible with common protecting groups used in oligonucleotide synthesis. This unit describes four procedures that consistently give high yields of the desired products. Taken together, they provide an arsenal of phosphonylation procedures that it compatible with most common protecting groups.
Stawinski
J
J
Stockholm University, Stockholm, Sweden.
Strömberg
R
R
D001671:Biochemistry / Q000379:methods*; D003853:Deoxyribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D003853:Deoxyribonucleosides; D007202:Indicators and Reagents; D063065:Organophosphonates; D012263:Ribonucleosides