title: Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus, Scopulariopsis brevicaulis.
abstract: Two novel cyclodepsipeptides, scopularides A and B, were found in the fungus Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium. In addition, the known fungal metabolite paxilline was identified. The structures of the scopularides were elucidated by NMR, MS, and chemical derivatization methods as cyclo-(3-hydroxy-4-methyldecanoyl-Gly-L-Val-D-Leu-L-Ala-L-Phe) and cyclo-(3-hydroxy-4-methyloctanoyl-Gly-L-Val-D-Leu-L-Ala-L-Phe) for scopularide A and B, respectively. Antibiotic activity against Gram-negative bacteria was absent and against Gram-positive bacteria was weak, but activity against several tumor cell lines was significant at 10 microg/mL.
authors.affiliation: Kieler Wirkstoffzentrum KiWiZ at IFM-GEOMAR, Am Kiel-Kanal 44, D-24106 Kiel, Germany.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Yu
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: Inga
authors.initials: I
authors.lastname: Kajahn
authors.forename: Rolf
authors.initials: R
authors.lastname: Schmaljohann
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017523:Croatia; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D047630:Depsipeptides; C531265:scopularide A; C531266:scopularide B