Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases.
OBJECTIVE
The balance between pro-inflammatory and anti-inflammatory cytokines may be crucial for determining the immunopathology of gingivitis (G) and periodontitis. This study aimed to analyse interleukin-1beta (IL-1beta), IL-11 and IL-12 levels in gingival crevicular fluid (GCF) of patients with G and chronic periodontitis (CP).


METHODS
Fourty subjects including 12 CP, 14 G and 14 controls (C) were enrolled. GCF samples were collected from six maxillary sites per patient and analysed for IL-1beta, IL-11 and IL-12 by an enzyme-linked immunosorbent assay.


RESULTS
Significantly lower concentrations of IL-11 were detected in CP compared with both G and C groups (p<0.05). The CP group had a significantly higher total amount of IL-12 and IL-1beta compared with the C group (p<0.05). The IL-11:IL-1beta cytokine ratio was higher in both G and C groups compared with the CP group. The IL-11:IL-1beta ratio became progressively lower with increasing probing depth (p<0.01).


CONCLUSIONS
Our data showed that IL-11 levels are significantly decreased in GCF from sites with periodontitis compared with G and healthy sites. Because of the possible preventive effect of IL-11 on inflammation, IL-11 may be an important factor in the therapeutic modulation of periodontal disease.
Yücel
Ozlem Ozer
OO
Department of Periodontology, Hacettepe University, Ankara, Turkey. ozlemozertr@gmail.com
Berker
Ezel
E
Gariboğlu
Semra
S
Otlu
Harika
H
D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005891:Gingivitis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D017370:Interleukin-11 / Q000032:analysis / Q000096:biosynthesis*; D018664:Interleukin-12 / Q000032:analysis / Q000096:biosynthesis*; D053583:Interleukin-1beta / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D010518:Periodontitis / Q000276:immunology* / Q000378:metabolism
D017370:Interleukin-11; D053583:Interleukin-1beta; D018664:Interleukin-12