title: Laboratory evaluation of cyromazine against insecticide-susceptible and -resistant mosquito larvae.
abstract: In this study, the activity of cyromazine was evaluated following WHO standard procedures against susceptible and resistant mosquito strains of Anopheles gambiae, Culex quinquefasciatus, and Aedes aegypti. The dose for 50% and 90% inhibition of adult emergence (IE50 and IE90) ranged from 0.028 mg/liter to 0.17 mg/liter and from 0.075 mg/liter to 0.42 mg/liter, respectively. The effects of cyromazine were closer to that of chitin synthesis inhibitors rather than that of juvenile hormone analogues, with only 10-20% pupal mortality. The toxicity of cyromazine was not strongly affected by the presence of common resistance mechanism, i.e., Kdr mutation and Ace.1(R) (resistance ratio from 0.5 to 2.3). The absence of cross resistance with common insecticides (pyrethroids, carbamates, organophosphates) makes cyromazine a potential candidate for disease vector control, especially for the management of insecticide resistance.
authors.affiliation: Institut de Recherche pour le Développement, Laboratoire de Lutte Contre les Insectes Nuisibles, 911 Avenue Agropolis, BP 64501, 34934 Montpellier 5, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Darriet
authors.forename: Morteza
authors.initials: M
authors.lastname: Zaim
authors.forename: Vincent
authors.initials: V
authors.lastname: Corbel
mesh_terms: D000818:Animals; D009033:Culicidae / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D011679:Pupa / Q000187:drug effects; D014227:Triazines / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D014227:Triazines; C028704:cyromazine