Tumor escape mechanism governed by myeloid-derived suppressor cells.
T-cell nonresponsiveness is a critical factor in immune escape and myeloid-derived suppressor cells play a major role in organizing this phenomenon. Recent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8(+) T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer.
Nagaraj
Srinivas
S
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA.
Gabrilovich
Dmitry I
DI
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D008285:Major Histocompatibility Complex; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control; D017382:Reactive Oxygen Species / Q000276:immunology
D017382:Reactive Oxygen Species