Wnt signaling in somite development.
During vertebrate embryogenesis, specialized mesodermal structures, called somites, give rise to a variety of mesodermal tissues including skeletal muscles, vertebrae and dermis. Development of the somites is a rhythmic process that involves a series of steps including segmentation of the paraxial mesoderm, epithelialization, somite formation, somite maturation, somite patterning and differentiation of somitic cells into different lineages. Wnt signaling has been found to play crucial roles in multiple steps of somite development. In this review, we present a brief overview of current knowledge on Wnt signaling events during the development of somites and their derivatives.
Geetha-Loganathan
Poongodi
P
Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstrasse 17, D-79104 Freiburg, Germany. poongo_3@yahoo.com
Nimmagadda
Suresh
S
Scaal
Martin
M
Huang
Ruijin
R
Christ
Bodo
B
D000818:Animals; D019521:Body Patterning; D047108:Embryonic Development / Q000502:physiology*; D006801:Humans; D008648:Mesoderm / Q000502:physiology; D008855:Microscopy, Electron, Scanning; D015398:Signal Transduction; D051153:Wnt Proteins / Q000502:physiology* / Q000648:ultrastructure
D051153:Wnt Proteins