[DNA adducts in human female genital organs].
DNA adducts, one of genetic damages markers, precede and finally can lead to oncogenic mutations. They appear in genome as a result of DNA bases damages caused by various and numerous environmental factors eg. ultraviolet light, ionic radiation, toxins and also endogenic substances, for example estrogens. It is believed that the creation of DNA adducts is a necessary but insufficient process for the neoplastic transformation of the cell. The following review presents concise knowledge about the DNA adducts creation and their sequels served in healthy and cancerous tissues of the female genital organs, on the base of the available data.
Postawski
Krzysztof
K
II Katedra i Klinika Ginekologii AM w Lublinie. postawski@onet.eu
Przadka-Rabaniuk
Dorota
D
Monist
Marta
M
Baranowski
Włodzimierz
W
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002273:Carcinogens / Q000633:toxicity; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018736:DNA Adducts / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004574:Electromagnetic Fields; D004781:Environmental Exposure; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics*; D005836:Genitalia, Female / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D006801:Humans; D014466:Ultraviolet Rays
D014408:Biomarkers, Tumor; D002273:Carcinogens; D018736:DNA Adducts; D004967:Estrogens