Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines.
The first indirubin-N'-glycosides were prepared based on reactions of isatin-N'-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N'-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N'-rhamnosides.
Libnow
Stefanie
S
Institut für Chemie der Universität Rostock, Germany.
Methling
Karen
K
Hein
Martin
M
Michalik
Dirk
D
Harms
Manuela
M
Wende
Kristian
K
Flemming
Anke
A
Köckerling
Martin
M
Reinke
Helmut
H
Bednarski
Patrick J
PJ
Lalk
Michael
M
Langer
Peter
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D006027:Glycosides; D007211:Indoles; C027185:indirubin