Experimental autoimmune encephalomyelitis (EAE).
The procedures described in this unit utilize murine models exclusively since murine EAE often results in a relapsing/remitting disease, similar to the early phase of most MS patients. EAE in the Lewis rat is a monophasic illness in which animals experience a single episode of paralysis from which most recover completely. This unit presents two methods for inducing EAE in mice: active induction and adoptive transfer.
Racke
M K
MK
University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas, USA.
D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D004198:Disease Susceptibility; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology; D005260:Female; D007114:Immunization / Q000379:methods; D051379:Mice; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000276:immunology / Q000633:toxicity; D010446:Peptide Fragments / Q000276:immunology / Q000633:toxicity
D004676:Myelin Basic Protein; D010446:Peptide Fragments