Glutathione peroxidase 1 C593T polymorphism is associated with lobar intracerebral hemorrhage.
BACKGROUND
Oxidative stress plays an important role in vascular pathology and contributes to the pathophysiology of primary intracerebral hemorrhage (PICH). Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system. Here, we investigated whether a functional C593T polymorphism of GPX1 gene is associated with PICH in a Polish population.


METHODS
Genotyping was performed in 192 PICH patients and 197 unrelated controls matched for age and sex. All were of Caucasian origin. The C593T GPX1 polymorphism was investigated using the polymerase chain reaction/restriction fragment length polymorphism method.


RESULTS
Multivariable logistic regression analysis revealed a significant association between genotypes containing the T allele and the entire PICH group (OR = 1.53; 95% CI = 1.02-2.29) and lobar PICH (OR = 2.36; 95% CI = 1.31-4.26) but not nonlobar PICH (OR = 1.19; 95% CI = 0.75-1.89).


CONCLUSIONS
We found a positive association between the studied GPX1 polymorphism and lobar PICH in a Polish population.
Pera
Joanna
J
Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl
Slowik
Agnieszka
A
Dziedzic
Tomasz
T
Pulyk
Roman
R
Wloch
Dorota
D
Szczudlik
Andrzej
A
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics; D000094765:Glutathione Peroxidase GPX1
D005979:Glutathione Peroxidase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human