title: Traditional vs accelerated approaches to post-operative rehabilitation following matrix-induced autologous chondrocyte implantation (MACI): comparison of clinical, biomechanical and radiographic outcomes.
abstract: OBJECTIVE
  To determine the effectiveness of 'accelerated' compared to 'traditional' post-operative load bearing rehabilitation protocols following matrix-induced autologous chondrocyte implantation (MACI).
  
  
  METHODS
  A randomized controlled study design was used to investigate clinical, biomechanical and radiographic assessment at 3 months post-surgery in 62 patients following MACI to the medial or lateral femoral condyle. Both rehabilitation interventions sought to protect the implant for an initial period, then incrementally increase load bearing. Under the 'accelerated' protocol, patients reached full weight bearing at 8 weeks post-surgery, compared to 11 weeks for the 'traditional' group.
  
  
  RESULTS
  Patients in the 'accelerated' group achieved greater 6 min walk distances and daily activity levels as measured by accelerometry (P<0.05) compared to the 'traditional' group. Furthermore, the 'accelerated' group reported significantly better improvement in knee pain at 12 weeks as indicated by the Knee Injury and Osteoarthritis Outcome Score (P<0.05), and regardless of the rehabilitation protocol employed, no patient suffered any adverse effect to the implant as assessed by magnetic resonance imaging at 3 months. Comparison of each rehabilitation group with an unaffected control group revealed a significant difference in peak knee adduction and flexion moments for the traditional group (P<0.05). However, there was no difference for accelerated patients (P>0.05), which may demonstrate a faster return to knee loading patterns typically observed in unaffected subjects.
  
  
  CONCLUSIONS
  The 'accelerated' load bearing approach that reduced the length of time spent ambulating on crutches resulted in reduced knee pain, improved function, no graft complications and may speed up the recovery of normal gait function. Patient follow-up to at least 24 months would be required to observe longer-term graft outcomes.
authors.affiliation: The School of Sport Science, Exercise and Health, The University of Western Australia, Nedlands, Perth, Western Australia 6009, Australia. jayebert@cyllene.uwa.edu.au
authors.forename: J R
authors.initials: JR
authors.lastname: Ebert
authors.forename: W B
authors.initials: WB
authors.lastname: Robertson
authors.forename: D G
authors.initials: DG
authors.lastname: Lloyd
authors.forename: M H
authors.initials: MH
authors.lastname: Zheng
authors.forename: D J
authors.initials: DJ
authors.lastname: Wood
authors.forename: T
authors.initials: T
authors.lastname: Ackland
mesh_terms: D000293:Adolescent; D000328:Adult; D002358:Cartilage, Articular / Q000601:surgery / Q000637:transplantation*; D019902:Chondrocytes / Q000637:transplantation*; D004185:Disability Evaluation; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery*; D011182:Postoperative Care / Q000534:rehabilitation; D016059:Range of Motion, Articular / Q000502:physiology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014182:Transplantation, Autologous / Q000379:methods* / Q000534:rehabilitation; D016474:Weight-Bearing / Q000502:physiology