Synthesis of fluorinated nucleosides.
Two practical synthetic approaches to the production of lodenosine [FddA, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine] via 6-chloropurine riboside or 6-chloropurine 3'-deoxyriboside are described. The reaction sequence contains new fluorination methods and new applications of radical reduction. The reagents and reaction conditions of each step have been carefully selected to ensure robustness and safety.
Katayama
Satoshi
S
AminoScience Laboratories, Ajinomoto Co., Kanagawa, Japan.
Takamatsu
Satoshi
S
Hirose
Naoko
N
Izawa
Kunisuke
K
Maruyama
Tokumi
T
D002851:Chromatography, High Pressure Liquid; D005461:Fluorine / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D007202:Indicators and Reagents; D009705:Nucleosides; D005461:Fluorine