Managing immunocompromised animals.
This unit describes some commonly used methods for maintaining immunocompromised rodents, specifically mice, to prevent infections from adventitious pathogens. The basic protocol describes the microisolation housing unit, while alternate procedures cover individually ventilated isolator housing, laminar-flow rack housing, flexible-film isolator housing, and barrier facility housing.
Donovan
John
J
Wyeth Research, Collegeville, Pennsylvania.
Brown
Patricia
P
National Institutes of Health, Bethesda, Maryland.
D000818:Animals; D001107:Architectural Accessibility; D004780:Environment, Controlled; D016867:Immunocompromised Host; D017053:Infection Control / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D013047:Specific Pathogen-Free Organisms; D013242:Sterilization; D014691:Ventilation / Q000295:instrumentation