Key molecules involved in receptor-mediated lymphocyte activation.
This unit, along with Unit 11.9B, provides a summary of our current knowledge about various signaling pathways critical to the function of immune cells. Here, our understanding of T cell receptor (TCR)- and B cell receptor (BCR)-mediated signaling is summarized. A schematic representation of immunologically relevant cytokine receptors and the Janus Family Kinases (JAKs) that is activated through these receptors is provided, along with details about molecules involved in interleukin 2 mediated signal transduction.
O'Shea
J J
JJ
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Johnston
J A
JA
Kehrl
J
J
Koretzky
G
G
Samelson
L E
LE
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D011494:Protein Kinases / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D011494:Protein Kinases