title: Invasive intracranial aspergillosis: the management dilemmas.
abstract: BACKGROUND
  Invasive intracranial aspergillosis remains a disease with high morbidity and mortality. The rapid increase in the incidence of this disease led us to review the literature and formulate a treatment protocol for such patients.
  
  
  METHODS
  An analysis of 46 patients with invasive intracranial aspergillosis is presented and the subgroups of extradural and intradural variety are evaluated with different treatment strategies.
  
  
  RESULTS
  Patients with extradural form of disease had 100% survival, whereas antifungal chemotherapy preloading tends to provide a better outcome.
  
  
  CONCLUSIONS
  Extradural aspergillosis does not need chemotherapy preloading, whereas intradural variant may have improved survival chances after preloading. Liposomal formulation has an advantage of shortened time duration for preloading, because the daily administration dose is 6 times higher than conventional preparation.
authors.affiliation: Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India. satya_sandee@yahoo.com
authors.forename: Sandeep
authors.initials: S
authors.lastname: Mohindra
authors.forename: Kanchan Kumar
authors.initials: KK
authors.lastname: Mukherjee
authors.forename: Rajesh
authors.initials: R
authors.lastname: Chhabra
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Gupta
authors.forename: Rahul
authors.initials: R
authors.lastname: Gupta
authors.forename: Virender Kumar
authors.initials: VK
authors.lastname: Khosla
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001927:Brain Diseases / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003399:Craniotomy; D003646:Debridement; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B