Immunobiology of the TAM receptors.
Recent studies have revealed that the TAM receptor protein tyrosine kinases--TYRO3, AXL and MER--have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.
Lemke
Greg
G
Molecular Neurobiology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA. lemke@salk.edu
Rothlin
Carla V
CV
D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D007694:Killer Cells, Natural / Q000166:cytology; D008264:Macrophages / Q000473:pathology; D015513:Oncogene Proteins / Q000276:immunology*; D010587:Phagocytosis; D011518:Proto-Oncogene Proteins / Q000276:immunology*; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D018121:Receptors, Cytokine / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase
D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; C097072:MERTK protein, human; D020794:Receptor Protein-Tyrosine Kinases; C084944:TYRO3 protein, human; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase; C000722289:AXL protein, human