title: Structure and function of animal cryptochromes.
abstract: Cryptochrome (CRY) is a photolyase-like flavoprotein with no DNA-repair activity but with known or presumed blue-light receptor function. Animal CRYs have DNA-binding and autokinase activities, and their flavin cofactor is reduced by photoinduced electron transfer. In Drosophila, CRY is a major circadian photoreceptor, and in mammals, the two CRY proteins are core components of the molecular clock and potential circadian photoreceptors. In mammals, CRYs participate in cell cycle regulation and the cellular response to DNA damage by controlling the expression of some cell cycle genes and by directly interacting with checkpoint proteins.
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
authors.forename: N
authors.initials: N
authors.lastname: Oztürk
authors.forename: S-H
authors.initials: SH
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Ozgür
authors.forename: C P
authors.initials: CP
authors.lastname: Selby
authors.forename: L
authors.initials: L
authors.lastname: Morrison
authors.forename: C
authors.initials: C
authors.lastname: Partch
authors.forename: D
authors.initials: D
authors.lastname: Zhong
authors.forename: A
authors.initials: A
authors.lastname: Sancar
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002940:Circadian Rhythm; D056931:Cryptochromes; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019143:Evolution, Molecular; D005136:Eye Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D005420:Flavoproteins / Q000737:chemistry* / Q000235:genetics / Q000266:history / Q000502:physiology*; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010777:Photochemistry; D017956:Photoreceptor Cells, Invertebrate / Q000737:chemistry / Q000502:physiology; D020419:Photoreceptor Cells, Vertebrate / Q000737:chemistry / Q000502:physiology; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D056931:Cryptochromes; D029721:Drosophila Proteins; D005136:Eye Proteins; D005420:Flavoproteins; D043562:Receptors, G-Protein-Coupled; C119828:cry protein, Drosophila; D004255:Deoxyribodipyrimidine Photo-Lyase