[Possibility of inverse development of morphological changes in the rat myocardium provoked by large doses of dopamine].
It is shown that Wistar male rats keeping without medication and stressful effects for a month after administration of big doses of dopamine for two weeks does not lead to complete inverse development of heart remodeling. A decrease of the heart's mass occurs mainly because of a decrease of the right ventricle mass. The greatest changes of the extracellular matrix take place in the right ventricle: collagen level grows more noticeably, edema of the extracellular space relieves, correlations between collagen and blood vessels, cardiac hystiocytes and blood vessels increase aggravating right ventricular remodeling.
Veber
V R
VR
Rubanova
M P
MP
Proshina
L G
LG
Zhmaĭlova
S V
SV
Gubskaia
P M
PM
Goritsyna
V E
VE
D000818:Animals; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005355:Fibrosis; D006352:Heart Ventricles / Q000187:drug effects* / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology*; D020257:Ventricular Remodeling / Q000187:drug effects*
D013566:Sympathomimetics; D004298:Dopamine