title: The effect of age and gender on outcome after treatment for colon carcinoma. A population-based study in the Uppsala and Stockholm region.
abstract: BACKGROUND
  The aim of this study was to assess whether there are differences in treatment strategy and outcome between different age cohorts among men and women with colon cancer.
  
  
  METHODS
  All patients with colon cancer included in the regional quality registry in Uppsala/Orebro and Stockholm between 1996 and December 2004 were analysed (n=11002). Patients were divided into three age categories: < or =65 years, 66-80 years and >80 years.
  
  
  RESULTS
  Overall and cancer-specific survival decreased with increasing age for stages II and III colon cancer but was not influenced by gender. Older patients with stage III tumours were less likely to be referred for chemotherapeutic treatment and there was a decrease in cancer-specific survival with increasing age, from 63.7% to 51.0% to 38.4% in the three age groups. Postoperative morbidity and the number of reoperations was significantly higher in men than in women.
  
  
  CONCLUSIONS
  The present study shows lower cancer-specific survival among older patients than among younger patients. Gender was not a prognostic factor in cancer-specific survival.
authors.affiliation: Department of Surgery, University Hospital Uppsala, Sweden.
authors.forename: Barbara L
authors.initials: BL
authors.lastname: van Leeuwen
authors.forename: Lars
authors.initials: L
authors.lastname: Påhlman
authors.forename: Ulf
authors.initials: U
authors.lastname: Gunnarsson
authors.forename: Annika
authors.initials: A
authors.lastname: Sjövall
authors.forename: Anna
authors.initials: A
authors.lastname: Martling
mesh_terms: D000230:Adenocarcinoma; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012042:Registries; D012737:Sex Factors; D016019:Survival Analysis; D013548:Sweden; D016896:Treatment Outcome