title: Optic disc cupping after optic neuritis evaluated with optic coherence tomography.
abstract: OBJECTIVE
  To determine whether the optic disc experiences cupping after an episode of optic neuritis as assessed by optical coherence tomography (OCT).
  
  
  METHODS
  A total of 50 patients with unilateral optic neuritis and 50 age- and sex-matched controls were studied. A complete examination, including visual acuity (VA), visual fields, and OCT scanning of the optic nerve head was performed. Mean cup-to-disc (C/D) ratios in the affected eyes were compared with fellow and control eyes.
  
  
  RESULTS
  Mean C/D area ratio (CDAR), C/D vertical ratio (CDVR), and C/D horizontal ratio (CDHR) were significantly larger in the affected eyes compared to fellow (P<0.001) and control eyes (P<0.05). The asymmetry in CDAR, CDVR, and CDHR between both eyes in the patients with optic neuritis was equal to or greater than 0.2 in 24, 28, and 30% respectively. A significant inverse correlation was found between the C/D ratios asymmetry and retinal nerve fibre layer (RNFL) thickness (P<0.05).
  
  
  CONCLUSIONS
  A significant increase in C/D ratio can be detected by OCT after unilateral optic neuritis, inversely correlated with RNFL thickness, and VA.
authors.affiliation: Ophthalmology Department, Glaucoma Unit, Hospital Ramón y Cajal, Madrid, Spain. grebolleda@telefonica.net
authors.forename: G
authors.initials: G
authors.lastname: Rebolleda
authors.forename: S
authors.initials: S
authors.lastname: Noval
authors.forename: I
authors.initials: I
authors.lastname: Contreras
authors.forename: F
authors.initials: F
authors.lastname: Arnalich-Montiel
authors.forename: J L
authors.initials: JL
authors.lastname: García-Perez
authors.forename: F J
authors.initials: FJ
authors.lastname: Muñoz-Negrete
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D009902:Optic Neuritis / Q000150:complications*; D012160:Retina / Q000473:pathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014794:Visual Fields; D055815:Young Adult