Overview of mouse assays of ethanol intoxication.
There are many behavioral assays to assess sensitivity to ethanol intoxication in mice. Most are simple to implement, and are sensitive to a particular dose range of ethanol. Most reflect genetic influences, and each test appears to reflect the contribution of a relatively distinct collection of genes. This genetic heterogeneity implies that no single test can claim to capture the construct "ethanol intoxication" completely. Depending on the test, and when measurements are made, acute functional tolerance to even a single dose of ethanol must be considered as a contributing factor. Whether or not a test is conducted in naïve mice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several.
Crabbe
John C
JC
Portland VA Medical Center, Portland, Oregon, USA.
Cameron
Andy J
AJ
Munn
Elizabeth
E
Bunning
Mark
M
Wahlsten
Douglas
D
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000633:toxicity*; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D051379:Mice
D002492:Central Nervous System Depressants; D000431:Ethanol