Unequal tissue expression of proteins from the PA/PAI system, myoma necrosis, and uterus survival after uterine artery occlusion.
OBJECTIVE
To further the understanding of the mechanism behind myoma necrosis and uterus survival after uterine artery occlusion.


METHODS
Myomal and myometrial gene transcription and protein expression of tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor type 1 (PAI-1) were investigated in 30 uteri.


RESULTS
Compared with myometrial expression, myomal expression was less for uPA mRNA (1.34%+/-2.18% vs 2.84%+/-2.97%; P<0.05) and greater for PAI-1 mRNA (2.67%+/-1.82% vs 1.27%+/-1.99%; P<0.05), but the difference in tPA mRNA expression was not significant. Accordingly, compared with myometrial expression, myomal expression was less for the uPA protein (P<0.05) and greater for the PAI-1 protein (P<0.05), but the difference in tPA protein was not significant.


CONCLUSIONS
The PA/PAI system was found to be expressed differently in myomas and the myometrium, which may play a role in uterus survival and myoma necrosis after uterine artery occlusion.
Cheng
Zhongping
Z
Department of Obstetrics and Gynecology, Yangpu District Central Hospital, Shanghai, China. mdcheng18@263.net
Xie
Yan
Y
Dai
Hong
H
Hu
Liping
L
Zhu
Yu
Y
Gong
Jun
J
D000328:Adult; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000628:therapy*; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000628:therapy*; D014599:Uterus / Q000098:blood supply
D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator