[Study of hepatoprotective activity of ethylmethylhydroxypyridine fumarate and lipoate in the experimental toxic hepatitis].
The authors have studied hepatoprotective actions of new derivatives of 3-hydroxipyridine on an experimental model of toxic hepatitis (140 white mice). Mexidol and berlithion are choosed as the preparations of comparison. The method of light microscopy is used for the exploration of morphological changes. The cytolytic contents activity, catalase activity and the level of MDA have been determined in blood serum. The antitoxic effect is valued by the survival of the animals. It is found that all examined bonds is corrected morphological changes in toxic hepatitis and increased the index of animals survival, which is more expressed than the preparations of comparison.
Semenova
E V
EV
Inchina
V I
VI
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*
C529703:2-ethyl-6-methyl-3-hydroxypyridine fumarate; C529704:2-ethyl-6-methyl-3-hydroxypyridine lipoate; D010847:Picolines; D020011:Protective Agents; C070020:emoxypine succinate; D008315:Malondialdehyde; D002251:Carbon Tetrachloride