title: [The experimental study of creating a new rat scarring model by inserting absorbable gelatin sponge into rats' excisional wounds].
abstract: OBJECTIVE
  To explore the possibility of creating a rat new scar model by inserting gelatin sponge into rat excisional wounds.
  
  
  METHODS
  Two full-thickness wounds were created in each of total 49 SD rats. In the Experimental group (n = 19), a regular incisional wound (1 cm) was created on the left side, and an excisional wound of 1.0 cm x 0.2 cm was created on the right side with a gelatin sponge inserted. In control 1 group (n = 15), an excisional wound with sponge insertion was created on both sides of rats. In control 2 group (n = 15), two excisional wounds were created on both sides, and only one side wounds were inserted with a sponge. Animals were sacrificed at various time points for different examinations.
  
  
  RESULTS
  The wound/scar width increased 4 - 11 times in inserted wounds than in regular incisional wounds (P < 0.01), with an obvious delay of epithelialization. No difference in wound/scar width was found in both sides of wounds of control 1 group at various locations. In contrast to the linear scar of sponge-inserted wounds, contracted and irregular scar was found in non-inserted wounds of control 2 group.
  
  
  CONCLUSIONS
  Gelatin sponge insertion can create a thick linear scar in rat wounds, and thus provides a new model for scar research.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gao
authors.forename: Ze-Hao
authors.initials: ZH
authors.lastname: Cai
authors.forename: Dan
authors.initials: D
authors.lastname: Deng
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zong
authors.forename: De-Min
authors.initials: DM
authors.lastname: Yin
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Cao
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D005781:Gelatin Sponge, Absorbable; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology; D013536:Suture Techniques; D014945:Wound Healing