[How useful is the combination of B vitamins and analgesic agents?].
Vitamins of the B group have long been used to treat neuropathies of different origins and the accompanying pain. A combination of the vitamins B(1), B(6), and B(12) prevents the slowing of impulse conduction produced by tetanic stimulation in diabetic mice. In patients suffering from diabetic neuropathy, B vitamins alleviate pain in the upper extremities. Thermosensitivity is restored by B vitamins in the upper but not in the lower extremities. It has recently also been reported that a combination of the vitamins B1, B6, and B12 has analgesic properties in non-neuropathic conditions. In animal experiments, B vitamins diminish nociceptive responses in spinal and thalamic neurones and potentiate the antinociceptive effect of analgesic agents. Similarly, B vitamins potentiate the therapeutic effect of diclofenac in patients suffering from acute low back pain.
Jurna
I
I
Institut für Pharmakologie und Toxikologie, Universität des Saarlandes, W-6650, Homburg/Saar, BRD.
Reeh
P W
PW