title: Scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl)acetic acid.
abstract: The efficient, scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl)acetic acid in enantiomerically pure form is reported using environmentally benign conditions in 30% overall yield (6 steps) for the (S)-isomer, in 27% (7 steps) for the (R)-isomer, from cyclohexanone.
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0343, USA.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Vamos
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: C530611:2-(1-hydroxy-2-oxocyclohexyl)acetic acid; D000085:Acetates; D003512:Cyclohexanones; C036468:cyclohexanone