title: Asymmetric organocatalysis: from infancy to adolescence.
abstract: After an initial period of validating asymmetric organocatalysis by using a wide range of important model reactions that constitute the essential tools of organic synthesis, the time has now been reached when organocatalysis can be used to address specific issues and solve pending problems of stereochemical relevance. This Review deals with selected studies reported in 2006 and the first half of 2007, and is intended to highlight four main aspects that may be taken as testimony of the present status and prospective of organocatalysis: a) chemical efficiency; b) discovery of new substrate combinations to give new asymmetric syntheses; c) development of new catalysts for specific purposes by using mechanistic findings; and d) applications of organocatalytic reactions in the asymmetric total synthesis of target natural products and known compounds of biological and pharmaceutical relevance.
authors.affiliation: Dipartimento di Chimica, Università di Ferrara, Via L. Borsari 46-44100 Ferrara, Italy. adn@unife.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dondoni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Massi
mesh_terms: D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000639:trends; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D009930:Organic Chemicals