[Levels of some auto-antibodies and C-peptide in insulin-treated patients with diabetes mellitus (DM) depending on gender of the patients and disease duration].
Determination of antibodies to thyroid peroxidase was recently proposed to single out subgroups among patients with DM1 for following clinical and genetic studies. 73 men and 64 women who are being treated with insulin and included in territorial register of patients with DM of Mariupol city, Donetsk region, Ukraine. Average age of patients at the stage of investigation was 35.17+/-1.16, the duration of the disease was 11.85+/-0.74, BMI-23.13+/-0.32 kg/m2, HBA1c9.23+/-0.25, C-peptide 0.48+/-0.09 nmol/l, glutaminic acid decarboxylase antibodies-GADAs-0.63+/-0.04 units/ml and did not depend on gender. Patients aged less then 30 years had their level of GADAbs and TPOAbs changed linearly correlated with the duration of diabetes mellitus. Obtained data can be used to assess subgroups among patients with DM1.
Likhonosov
P N
PN
Khalangot
N D
ND
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002096:C-Peptide / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011237:Predictive Value of Tests; D012042:Registries; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors; D014455:Ukraine / Q000453:epidemiology
D001323:Autoantibodies; D015415:Biomarkers; D002096:C-Peptide; D007328:Insulin