[Effects of recombined neuregulin on healthy Macaca mulatta hearts].
To explore the effects of recombined Neuregulin on the heart of healthy Macaca mulatta, 10 healthy adult Macaca mulatta were randomly divided into two groups and were injected with the same doses of recombined Neuregulin and normal saline, respectively. At the same time, related indices were detected by 2-dimensional echocardiography and M-mode echocardiography. All indices were compared between the two groups and among different phases. Recombined Neuregulin had effects on LVEDD (left ventricular end-diastolic diameter), LVEDV (left ventricular end-diastolic volume), LVESV (left ventricular end-systolic volume) and SV (Stroke volume), and the effects changed with time. However, no significant changes were seen on EF (Ejection fraction) and FS (Fractional shortening). In conclusion, recombined Neuregulin has effects on the left ventricular volume of healthy Macaca mulatta, but no significant effect on cardiac contractility.
Tang
Hong
H
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Huang
He
H
Zhang
Yan
Y
Chen
Jiao
J
Zhao
Yinglan
Y
Wang
Li
L
D000818:Animals; D004452:Echocardiography / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D020880:Neuregulins / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D011897:Random Allocation; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects*
D020880:Neuregulins; D011994:Recombinant Proteins