title: Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor.
authors.affiliation: Structural Biology and Computational Chemistry, Chemical and Screening Sciences, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA. mmarkus@wyeth.com
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Markus
authors.forename: Brian
authors.initials: B
authors.lastname: Dwyer
authors.forename: Scott
authors.initials: S
authors.lastname: Wolfrom
authors.forename: Jianchang
authors.initials: J
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Karl
authors.initials: K
authors.lastname: Malakian
authors.forename: James
authors.initials: J
authors.lastname: Wilhelm
authors.forename: Désirée H H
authors.initials: DH
authors.lastname: Tsao
mesh_terms: D020134:Catalytic Domain; D006801:Humans; D053508:Matrix Metalloproteinase 12 / Q000737:chemistry*; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011480:Protease Inhibitors / Q000737:chemistry*; D011487:Protein Conformation; D012996:Solutions; D013876:Thiophenes / Q000737:chemistry*; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: C530741:N-(dibenzo(b,d)thiophene-3-sulfonyl)valine; D011480:Protease Inhibitors; D012996:Solutions; D013876:Thiophenes; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12; D014633:Valine