Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease.
In our case-control study we analyzed two functional IL18 gene promoter polymorphisms (-137G/C and -607C/A) and an additional polymorphism at position -656 (G/T) in Alzheimer patients and healthy controls in order to verify the involvement of these genetic variations in the onset of Alzheimer disease. No significant differences were detected for the three IL18 SNPs between AD patients and controls. The haplotypes distribution also did not show any difference within AD subjects and controls.
Segat
Ludovica
L
Department of Developmental and Reproductive Sciences, University of Trieste, Via dell'Istria 65/1, 34137 Trieste, Italy. segat@burlo.trieste.it
Milanese
Michele
M
Arosio
Beatrice
B
Vergani
Carlo
C
Crovella
Sergio
S
D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D015415:Biomarkers; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
D015415:Biomarkers; D005819:Genetic Markers; D020382:Interleukin-18