Residual functional connectivity in the split-brain revealed with resting-state functional MRI.
Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
Uddin
Lucina Q
LQ
New York University Child Study Center, New York, NY 10016, USA. lucina.uddin@med.nyu.edu
Mooshagian
Eric
E
Zaidel
Eran
E
Scheres
Anouk
A
Margulies
Daniel S
DS
Kelly
A M Clare
AM
Shehzad
Zarrar
Z
Adelstein
Jonathan S
JS
Castellanos
F Xavier
FX
Biswal
Bharat B
BB
Milham
Michael P
MP
D000328:Adult; D000368:Aged; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004827:Epilepsy / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000502:physiology*; D050812:Split-Brain Procedure