A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates.
Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.
Sharma
Jaswinder
J
Department of Chemistry & Biochemistry and Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Chhabra
Rahul
R
Yan
Hao
H
Liu
Yan
Y
D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry*
D008024:Ligands; D009841:Oligonucleotides; D013859:Thiocarbamates; D006046:Gold