title: Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats.
abstract: Vanadium compounds have been recognized for their hypoglycemic effects; however, potential short and long-term vanadium toxicity has slowed the acceptance for therapeutic use. In the present work, three batches of vanadium-enriched chickpea sprout (VCS) were prepared by incubating chickpea seeds in presence of 200, 100, and 50 microg/ml of sodium orthovanadate (SOV). The effects of oral administration of chickpea sprout (CS) and VCS food for 8 weeks on streptozotocin-induced (STZ) diabetic rats were investigated. Both CS and VCS food was found to ameliorate some hyperglycemic symptoms of the diabetic rats, i.e. improve lipid metabolism, decrease blood glucose level, prevent body weight loss, and reduce impairment of diabetic related spatial learning and memory. Serum insulin was substantially elevated in treated diabetic rats, which is probably one important reason for the hypoglycemic effect. Compared with CS alone, VCS100 food exhibited remarkably enhanced effectiveness in alleviating diabetes induced hyperglycemia and memory loss. Moreover, vanadium-enriched chickpeas appeared to abolish the vanadium induced toxicity associated with administration of this metal for diabetes during the 8-week study period. This study suggested further work of the vanadium speciation in CS and novel hypoglycemic mechanism for the antidiabetic activity of vanadium agents. Vanadium containing (VCS) food could be a dietary supplement for the diabetic status.
authors.affiliation: Department of Physiology, Shandong University School of Medicine, Wenhua Xi Road, Jinan, Shandong 250012, People's Republic of China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Mao
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Sun
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhao
authors.forename: Hongxin
authors.initials: H
authors.lastname: Cai
authors.forename: Xiaoda
authors.initials: X
authors.lastname: Yang
authors.forename: Zuoli
authors.initials: Z
authors.lastname: Xia
authors.forename: Yujing
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D029863:Cicer / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000178:diet therapy*; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D007858:Learning; D008055:Lipids / Q000097:blood; D008297:Male; D008569:Memory Disorders / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D051381:Rats; D017208:Rats, Wistar; D036226:Seedlings / Q000378:metabolism*; D014639:Vanadium / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014639:Vanadium