title: Successful response to rituximab in two cases of acquired haemophilia refractory to standard-therapy.
abstract: Acquired autoantibodies against coagulation factors (acquired haemophilia) frequently constitute a life-threatening bleeding situation requiring a prompt therapeutic intervention, including control of bleeding and secondarily an attempt of eradication of the inhibitor by prolonged immunosuppressive therapy. The combination of oral corticosteroids and cyplophosphamide seems to be effective to eradicate the autoantibody, but some patients may be resistant. Another therapeutic approach, recently described, observes treatment with the chimeric anti-CD20 monoclonal antibody rituximab. We report two consecutively treated patients whose acquired FVIII inhibitors did not respond to standard immunosuppressive regimens, and only when rituximab was added to therapy, complete response and prolonged remission were obtained.
authors.affiliation: Hematology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Machado
authors.affiliation: Hematology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. jomaraya@yahoo.es.|, Apartado de Correos 172, 38080, Santa Cruz de Tenerife, Spain. jomaraya@yahoo.es.
authors.forename: J M
authors.initials: JM
authors.lastname: Raya
authors.affiliation: Hematology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Martín
authors.affiliation: Hematology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Morabito
authors.affiliation: Hematology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Brito
authors.affiliation: Hematology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez-Martín
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood / Q000276:immunology; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000276:immunology; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D000069283:Rituximab
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D019774:Blood Coagulation Factor Inhibitors; D007155:Immunologic Factors; D000069283:Rituximab; C078147:F8 protein, human; D005169:Factor VIII