Synthesis of beta-L-2'-deoxythymidine (L-dT).
The "unnatural" l-nucleoside beta-l-2'-deoxythymidine (L-dT) is a potent, specific, and selective inhibitor of the replication of hepatitis B virus (HBV), which is currently in Phase III clinical trials. This unit describes, in detail, a semi-large-scale synthesis of l-dT. This convenient methodology produces l-dT in six steps starting with l-ribose and ending with a satisfactory overall yield of l-dT, and may be applied to other 2'-deoxynucleosides, incorporating different heterocyclic bases.
Pierra
Claire
C
Université Montpellier II, Montpellier, France.
Dukhan
David
D
Gosselin
Gilles
G
Sommadossi
Jean-Pierre
JP
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology; D013936:Thymidine / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D013936:Thymidine