The assessment of autoimmunological status and prevalence of different forms of celiac disease among children with type 1 diabetes mellitus and celiac disease.
This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM). The study group comprises 27 patients at the mean age of 12.30 years (+/-SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r = -0.35, p < .05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset.
Deja
Grazyna
G
Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, 40-752 Katowice, Poland. grazyna.d@mp.pl
Myrda
Anna
A
Jarosz-Chobot
Przemyslawa
P
Siekiera
Urszula
U
D000293:Adolescent; D000367:Age Factors; D001323:Autoantibodies / Q000276:immunology; D002446:Celiac Disease / Q000150:complications / Q000453:epidemiology* / Q000276:immunology*; D002648:Child; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013966:Thyroiditis / Q000150:complications / Q000453:epidemiology / Q000276:immunology
D001323:Autoantibodies