title: Antiarrhythmic effects of statins in heart failure.
abstract: In vitro heart failure models indicate that statins may be antiarrhythmic, but the mechanisms by which statins are antiarrhythmic are not completely understood. Several retrospective and post hoc analysis studies also indicate that statins can be antiarrhythmic in heart failure populations, but this was not confirmed by a recent large prospective randomized controlled clinical trial. Ongoing and future clinical trials will likely resolve the discrepancies between studies and further the understanding of how pleiotropic properties of statins can be antiarrhythmic in patients who have heart failure.
authors.affiliation: University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
authors.forename: Chirag M
authors.initials: CM
authors.lastname: Sandesara
authors.forename: Hamid
authors.initials: H
authors.lastname: Roodneshin
authors.forename: Salam
authors.initials: S
authors.lastname: Sbaity
authors.forename: Brian
authors.initials: B
authors.lastname: Olshansky
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology* / Q000628:therapy; D001808:Blood Vessels / Q000187:drug effects; D002986:Clinical Trials as Topic; D017147:Defibrillators, Implantable; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D007473:Ion Channels / Q000187:drug effects
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007473:Ion Channels