Skewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriage.
OBJECTIVE
To investigate if skewed X-chromosome inactivation (XCI) is associated with unexplained recurrent miscarriage (RM) in Greek women.


METHODS
This was a prospective case-control study. A methylation-sensitive assay was used to investigate the X-inactivation pattern of women with unexplained RM and controls.


RESULTS
Fifty-six of the 74 patients (75.7%) and 55 of 80 controls (68.8%) were informative. Among the informative cases, 6/56 (10.7%) women showed extreme XCI (>90%) and among the informative controls, 2/55 (3.6%) showed extreme XCI.


CONCLUSIONS
In the present study, women with unexplained RM showed a statistically nonsignificant increase in skewed XCI prevalence (10.7%) compared with control women (3.6%; p = 0.271).
Dasoula
A
A
Department of General Biology, Genetics Unit,University of Ioannina, Ioannina, Greece.
Kalantaridou
S
S
Sotiriadis
A
A
Pavlou
M
M
Georgiou
I
I
Paraskevaidis
E
E
Makrigiannakis
A
A
Syrrou
M
M
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006115:Greece; D006579:Heterozygote; D006801:Humans; D008297:Male; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011446:Prospective Studies; D011944:Receptors, Androgen / Q000235:genetics; D049951:X Chromosome Inactivation
D011944:Receptors, Androgen