Continuous glucose monitoring system in the screening of early glucose derangements in children and adolescents with cystic fibrosis.
BACKGROUND
In cystic fibrosis (CF), diabetes mellitus (DM) is associated with progression of pulmonary disease and nutritional impairment.


OBJECTIVE
To compare oral glucose tolerance test (OGTT) and continuous glucose monitoring system (CGMS) in patients with CF with early glucose derangements.


METHODS
Thirty-two patients with CF (5-20 years) with intermediate glucose values > 7.7 mmol/l during OGTT received a CGMS registration. Patients were classified into those with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and DM, according to glucose values at 120 min of OGTT and during CGMS. Furthermore BMI z-scores, forced expiratory volume in 1 second (FEV1%), number of respiratory infections/year, enzyme supplementation, and HbA1c were evaluated.


RESULTS
OGTT and CGMS derangements were in agreement in 43.7% of the patients. BMI z-scores, FEV1%, number of respiratory infections/ year, enzyme supplementation, and HbA1c did not differ among the three groups. HbA1c, correlated positively with 120 min OGTT (r = 0.34; p = 0.059), CGMS area (r = 0.35; p = 0.048) and the number of respiratory infections, and negatively with FEV1%.


CONCLUSIONS
Intermediate glucose values during OGTT should be considered as a screening test in patients with CF. CGMS can be useful in studying the early occurrence of glucose derangements in selected patients.
Franzese
Adriana
A
Department of Pediatrics, Federico II University, Naples, Italy. franzese@unina.it
Valerio
Giuliana
G
Buono
Pietro
P
Spagnuolo
Maria Immacolata
MI
Sepe
Angela
A
Mozzillo
Enza
E
De Simone
Ilaria
I
Raia
Valeria
V
D000293:Adolescent; D000328:Adult; D015190:Blood Glucose Self-Monitoring; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male
D005947:Glucose; D006442:Glycated Hemoglobin