Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
The methanol extract of galangal (the rhizomes of Alpinia officinarum L.) exhibited remarkable antitumor-promoting activity on an in vivo two-stage carcinogenesis test of mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Seven diarylheptanoids (1-7) were isolated and identified from the active fraction of the methanol extracts of the galangal. These compounds, 1-7, were evaluated for their inhibitory effects on TPA-induced inflammation (1 microg/ear) in mice. These compounds (1-7) tested showed marked anti-inflammatory effects, with a 50% inhibitory dose of 0.8-2.7 micromol/ear.
Yasukawa
Ken
K
Sun
Yi
Y
Kitanaka
Susumu
S
Tomizawa
Naoyuki
N
Miura
Motofumi
M
Motohashi
Shigeyasu
S
D015127:9,10-Dimethyl-1,2-benzanthracene; D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002273:Carcinogens; D036381:Diarylheptanoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000517:prevention & control; D010936:Plant Extracts / Q000494:pharmacology*; D027343:Rhizome; D012878:Skin Neoplasms / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate
D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D036381:Diarylheptanoids; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate