Transcriptome analysis of endocrine tumors: clinical perspectives.
There is considerable interest in the application of DNA microarrays to the pathologic evaluation of endocrine neoplasms. Improvements in tumor classification and prognostication, prediction of response to therapy, and comprehensive assessment of tumoral hormone production represent the major anticipated benefits. Here, some of the microarray studies that support the clinical use of transcriptome profiling for endocrine tumors are reviewed. In addition, some of the barriers to clinical implementation are discussed.
Giordano
T J
TJ
Department of Pathology, University of Michigan Health System, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0669, USA. giordano@umich.edu
D000818:Animals; D004273:DNA, Neoplasm / Q000235:genetics; D004701:Endocrine Gland Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis
D004273:DNA, Neoplasm