Nanoscale tools to selectively destroy cancer cells.
We present experimental data that demonstrate the potential of synthetic crown ether modified peptide nanostructures to act as selective and efficient chemotherapeutic agents that operate by attacking and destroying cell membranes.
Boudreault
Pierre-Luc
PL
Département de chimie and Centre de recherche sur la fonction, la structure et l'ingénierie des protéines, Faculté des sciences et génie, Université Laval, Québec, QC, CanadaG1K 7P4.
Arseneault
Mathieu
M
Otis
François
F
Voyer
Normand
N
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects*; D043844:Crown Ethers / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D043844:Crown Ethers; D010455:Peptides