title: Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors.
abstract: The oxindolylidene acetic acids having long N-alkyl chains exhibited strong inhibitory activity toward dual specificity phosphatase Cdc25A.
authors.affiliation: Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto 610-0395, Japan. shimazawa@m.tains.tohoku.ac.jp
authors.forename: Rumiko
authors.initials: R
authors.lastname: Shimazawa
authors.forename: Masami
authors.initials: M
authors.lastname: Kuriyama
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Shirai
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007510:Isatin / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: D000085:Acetates; D007211:Indoles; D007510:Isatin; D020687:cdc25 Phosphatases