Allostery: DNA does it, too.
Allostery is a central concept for understanding protein function and regulation. It is less well appreciated that DNA is allosteric, too, and that DNA conformational changes can by coupled to protein binding interactions on the DNA lattice. Allosteric DNA interactions are emerging as important features in the assembly of the molecular machines that regulate transcription.
Chaires
Jonathan B
JB
James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, Kentucky 40202, USA. j.chaires@louisville.edu
D000494:Allosteric Regulation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000378:metabolism; D011485:Protein Binding
D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D004247:DNA; D019696:Peptidylprolyl Isomerase