title: Zinc or magnesium supplementation modulates cd intoxication in blood, kidney, spleen, and bone of rabbits.
abstract: The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd group-received orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group-exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th and 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.
authors.affiliation: Institute of Toxicology Academic D. Soldatović, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia. zoricab@pharmacy.bg.ac.yu
authors.forename: Zorica Plamenac
authors.initials: ZP
authors.lastname: Bulat
authors.forename: Danijela
authors.initials: D
authors.lastname: Djukić-Cosić
authors.forename: Zivorad
authors.initials: Z
authors.lastname: Malicević
authors.forename: Petar
authors.initials: P
authors.lastname: Bulat
authors.forename: Vesna
authors.initials: V
authors.lastname: Matović
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002104:Cadmium / Q000097:blood*; D002105:Cadmium Poisoning / Q000097:blood* / Q000178:diet therapy; D019587:Dietary Supplements; D007668:Kidney / Q000378:metabolism*; D008274:Magnesium / Q000097:blood / Q000494:pharmacology*; D011817:Rabbits; D015032:Zinc / Q000097:blood / Q000494:pharmacology*
chemical_list: D002104:Cadmium; D008274:Magnesium; D015032:Zinc