title: Significant improvement in extensive lichen sclerosus with tacrolimus ointment and PUVA.
abstract: Lichen sclerosus is an uncommon, chronic inflammatory skin disorder of unknown origin. It is clinically characterized by sclerotic, whitish, atrophic-type lesions. The most frequent site of the lesions is generally the genital region, with about 15-20% having additional extragenital involvement. We present the case of a 62-year-old woman with a very extensive extragenital lichen sclerosus who showed great clinical and subjective improvement with 0.1% tacrolimus ointment and psoralen plus UVA (PUVA), without any topical or systemic adverse effects. Combined treatment of 0.1% tacrolimus ointment and PUVA may be a good option in extensive cases of lichen sclerosus or when other treatment options have failed, and has a good tolerability and safety profile.
authors.affiliation: Dermatology Department, Hospital Virgen de la Torre, Madrid, Spain. martavaldivielso@aed.es
authors.forename: Marta
authors.initials: M
authors.lastname: Valdivielso-Ramos
authors.forename: Celso
authors.initials: C
authors.lastname: Bueno
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Hernanz
mesh_terms: D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy*; D008875:Middle Aged; D009824:Ointments; D011701:PUVA Therapy; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus