title: Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress.
abstract: Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids.
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Fisiología-IBGM, Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Ganfornina
authors.forename: Sonia
authors.initials: S
authors.lastname: Do Carmo
authors.forename: Jose M
authors.initials: JM
authors.lastname: Lora
authors.forename: Sonia
authors.initials: S
authors.lastname: Torres-Schumann
authors.forename: Marci
authors.initials: M
authors.lastname: Vogel
authors.forename: Maria
authors.initials: M
authors.lastname: Allhorn
authors.forename: Constancio
authors.initials: C
authors.lastname: González
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bastiani
authors.forename: Eric
authors.initials: E
authors.lastname: Rassart
authors.forename: Diego
authors.initials: D
authors.lastname: Sanchez
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D053399:Apolipoproteins D / Q000235:genetics / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007858:Learning / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D054834:Lipocalins / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D010269:Paraquat / Q000494:pharmacology; D016019:Survival Analysis; D019076:Transgenes; D015854:Up-Regulation / Q000187:drug effects
chemical_list: C024328:APOD protein, human; D053399:Apolipoproteins D; D006023:Glycoproteins; D054834:Lipocalins; D026901:Membrane Transport Proteins; D010269:Paraquat