title: Streptococcal cell wall arthritis.
abstract: Streptococcal cell wall (SCW) arthritis in rats is an experimentally-induced inflammatory model with many features that resemble rheumatoid arthritis (RA) in humans. In this unit, Lewis rats are injected with an aqueous suspension of Group A SCW streptococcal cell wall peptidoglycan-polysaccharide polymers (SCW PG-PS) and observed for the development of arthritis. The resulting arthritis is biphasic. An acute phase typically develops within 48 hr, followed 10 to 21 days later by a chronic phase which persists for months. Support protocols are included for preparing Group A PG-PS and measuring PG-PS concentration.
authors.affiliation: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Wilder
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology*; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007274:Injections, Intraperitoneal; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D051381:Rats; D011917:Rats, Inbred Lew; D013291:Streptococcus / Q000737:chemistry / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000737:chemistry
chemical_list: D011135:Polysaccharides, Bacterial