A spoke in the wheel: calcium spikes disrupt yeast cell cycle.
A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca(2+) within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca(2+)-calcineurin signaling, nutrient sensing and regulation of the cell cycle.
Zhang
Yong-Qiang
YQ
Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rao
Rajini
R
D000638:Amiodarone / Q000494:pharmacology*; D019703:Calcineurin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D003593:Cytoplasm / Q000737:chemistry; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D019703:Calcineurin; D000638:Amiodarone; D002118:Calcium