title: Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis.
abstract: Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.
authors.affiliation: Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134, Napoli, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Esposito
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Pethoukov
authors.forename: Dmitri I
authors.initials: DI
authors.lastname: Svergun
authors.forename: Alessia
authors.initials: A
authors.lastname: Ruggiero
authors.forename: Carlo
authors.initials: C
authors.lastname: Pedone
authors.forename: Emilia
authors.initials: E
authors.lastname: Pedone
authors.forename: Rita
authors.initials: R
authors.lastname: Berisio
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D019281:Dimerization; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D012542:Scattering, Radiation; D017356:Synchrotrons; D014965:X-Rays
chemical_list: D001426:Bacterial Proteins; D037102:Lectins; C104578:heparin-binding hemagglutinin