Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform.
BACKGROUND
To investigate the clinical differences between pulse wave velocity and augmentation index in diabetic retinopathy.


METHODS
The subjects were 201 patients with type 2 diabetes. These subjects were measured for both augmentation index (AI) and brachial-ankle pulse wave velocity (baPWV) by a pulse wave analyzer. The relationships between AI, baPWV, and diabetic retinopathy were examined.


RESULTS
BaPWV was significantly higher in patients with diabetic retinopathy than in individuals without the disease. (20.13 +/- 3.66 vs.17.14 +/- 3.60 m/s p < 0.001) AI was higher in patients with diabetic retinopathy, but not significantly. (19.5 +/- 15.2 vs. 14.8 +/- 20.5% p = 0.14) The association between baPWV and diabetic retinopathy remained statistically significant after adjustment. (Odds ratio: 1.21 Per m/s, 95% confidence interval: 1.07-1.37) On the other hand, the association between AI and diabetic retinopathy was not statistically significant. (Odds ratio: 1.01 Per %, 95% confidence interval: 0.98-1.03)


CONCLUSIONS
BaPWV is associated with diabetic retinopathy, but AI is not. The clinical significance appears to be different between PWV and AI in patients with diabetes.
Ogawa
Osamu
O
Midorigaoka Ekimae Clinic, 1-1-1, Midorigaoka, Yachiyo city, Chiba Pref,, 276-0049, Japan. GGD03273@nifty.com
Hiraoka
Kiyoko
K
Watanabe
Takahiro
T
Kinoshita
Junichiro
J
Kawasumi
Masahiko
M
Yoshii
Hidenori
H
Kawamori
Ryuzo
R
D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011673:Pulsatile Flow / Q000502:physiology*