Synthesis of ribonucleosides by condensation using trimethylsilyl triflate.
This unit describes, in detail, the optimized condition for the synthesis of nucleosides making use of the trimethysilyl triflate-mediated silyl-Hilbert-Johnson synthesis. This unit focuses on the mechanistic understanding of this universal and conveniently applicable method.
Vorbrüggen
Helmut
H
Free University Berlin, Berlin, Germany.
Lagoja
Irene M
IM
Herdewijn
Piet
P
D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D012263:Ribonucleosides / Q000138:chemical synthesis*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D012263:Ribonucleosides; D014297:Trimethylsilyl Compounds