Solifenacin-induced small bowel pseudo-obstruction.
An 89-year-old woman was admitted to Johns Hopkins Hospital with a small bowel obstruction and symptoms of urinary retention. She had been started on solifenacin for bladder overactivity 10 days prior to her presentation. Withdrawal of the solifenacin resulted in a full recovery, which has persisted for greater than 6 months without surgical intervention. This is the first reported case report of small bowel pseudo-obstruction due to solifenacin.
Pemmaraju
Naveen
N
Department of General Internal Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Feldman
Leonard S
LS
D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis / Q000209:etiology*; D007421:Intestine, Small; D018727:Muscarinic Antagonists / Q000009:adverse effects*; D049268:Positron-Emission Tomography; D011812:Quinuclidines / Q000009:adverse effects*; D000069464:Solifenacin Succinate; D044005:Tetrahydroisoquinolines / Q000009:adverse effects*; D014056:Tomography, X-Ray; D053201:Urinary Bladder, Overactive / Q000188:drug therapy
D018727:Muscarinic Antagonists; D011812:Quinuclidines; D044005:Tetrahydroisoquinolines; D000069464:Solifenacin Succinate