title: [Analysis of the variation of 32 HIV-1 V3 loop from infected Chinese blood/plasma donors].
abstract: OBJECTIVE
  To characterize the variation in V3 loop of HIV-1 B'strains circulating in Chinese blood donors.
  
  
  METHODS
  The c2-c3 regions of the HIV envelop gene were amplified by nest-PCR from 32 HIV-1-infected blood donors in He Nan province in China. The BIOEDIT and MEGA software are used to analyze the sequences of V3 loop.
  
  
  RESULTS
  There are five types of central motifs of the 32 samples, in which GPGR and GPGQ are most common. More variations associated with T tropic/SI phenotype can be seen in AIDS group.
  
  
  CONCLUSIONS
  The V3 tip motifs of HIV-1B' strains circulating in Chinese blood donors are various, the different characterization of V3 loop between AIDS and asymptomatic patients indicates different biological phenotype and pathogenesis which warrant additional investigation.
authors.affiliation: Department of Infectious Disease. The You An Hospital affiliated to The Capital University of Medical Science. Beijing, 100069, China.
authors.forename: Lli
authors.initials: L
authors.lastname: Dai
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Lu
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.forename: De-xi
authors.initials: DX
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001782:Blood Donors; D002681:China; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D015699:HIV Envelope Protein gp120 / Q000032:analysis / Q000737:chemistry* / Q000235:genetics*; D015658:HIV Infections / Q000097:blood / Q000821:virology*; D015497:HIV-1 / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry; D010641:Phenotype
chemical_list: D015699:HIV Envelope Protein gp120; D009842:Oligopeptides