title: Mutation and control of the human immunodeficiency virus.
abstract: We examine the dynamics of infection by the human immunodeficiency virus (HIV), as well as therapies that minimize viral load, restore adaptive immunity, and use minimal dosage of anti-HIV drugs. Virtual therapies for wild-type infections are demonstrated; however, the HIV infection is never cured, requiring continued treatment to keep the condition in remission. With high viral turnover and mutation rates, drug-resistant strains of HIV evolve quickly. The ability of optimal therapy to contain drug-resistant strains is shown to depend upon the relative fitness of mutant strains.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Princeton University Princeton, P.O. Box CN5263, Princeton, NJ 08544-5263, USA. stengel@princeton.edu
authors.forename: Robert F
authors.initials: RF
authors.lastname: Stengel
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D004334:Drug Administration Schedule; D024882:Drug Resistance, Viral; D006678:HIV / Q000187:drug effects* / Q000472:pathogenicity* / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008962:Models, Theoretical; D016296:Mutagenesis / Q000276:immunology; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors