title: First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid.
abstract: The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6- endo-dig-cyclization of phenolic oxygens to the resulting alkynes.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Marcellino
authors.initials: M
authors.lastname: Rudyanto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Toshio
authors.initials: T
authors.lastname: Honda
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D002366:Cassia / Q000737:chemistry; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D006575:Heterocyclic Compounds, 3-Ring; C524027:cassiarin A