title: Dental amalgam and antibiotic- and/or mercury-resistant bacteria.
abstract: Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetracycline-, ampicillin-, erythromycin-, or chloramphenicol-resistant oral and urinary bacteria as compared with levels in children receiving composite fillings. Samples were collected at baseline, 3-6 months after the initial dental treatment, and annually for 7 years of follow-up. There were no statistically significant differences between treatment groups in the numbers of bacteria growing on antibiotic- or mercury-supplemented plates. This study provided no evidence that amalgam fillings on posterior teeth influenced the level of antibiotic- or mercury-resistant oral or urinary bacteria as detected by culture.
authors.affiliation: Box 357234, Department of, Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA. marilynr@u.washington.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Roberts
authors.forename: B G
authors.initials: BG
authors.lastname: Leroux
authors.forename: J
authors.initials: J
authors.lastname: Sampson
authors.forename: H S
authors.initials: HS
authors.lastname: Luis
authors.forename: M
authors.initials: M
authors.lastname: Bernardo
authors.forename: J
authors.initials: J
authors.lastname: Leitão
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D003723:Dental Amalgam / Q000378:metabolism / Q000494:pharmacology*; D003731:Dental Caries / Q000382:microbiology* / Q000628:therapy; D003793:Dental Restoration, Permanent / Q000379:methods; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009055:Mouth / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D003723:Dental Amalgam