title: The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation.
abstract: Since its beginning as a data collection more than 20 years ago, the TRANSFAC project underwent an evolution to become the basis for a complex platform for the description and analysis of gene regulatory events and networks. In the following, I describe what the original concepts were, what their present status is and how they may be expected to contribute to future system biology approaches.
authors.affiliation: Department of Bioinformatics, Medical School, University of Göttingen, Goldschmidtstr. 1, D-37077 Göttingen, Germany. e.wingender@med.uni-goettingen.de
authors.forename: Edgar
authors.initials: E
authors.lastname: Wingender
mesh_terms: D001709:Biotechnology / Q000379:methods; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D008954:Models, Biological; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology / Q000379:methods*; D018511:Systems Integration; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D020543:Proteome; D014157:Transcription Factors