title: TOPDOM: database of domains and motifs with conservative location in transmembrane proteins.
abstract: The TOPDOM database is a collection of domains and sequence motifs located consistently on the same side of the membrane in alpha-helical transmembrane proteins. The database was created by scanning well-annotated transmembrane protein sequences in the UniProt database by specific domain or motif detecting algorithms. The identified domains or motifs were added to the database if they were uniformly annotated on the same side of the membrane of the various proteins in the UniProt database. The information about the location of the collected domains and motifs can be incorporated into constrained topology prediction algorithms, like HMMTOP, increasing the prediction accuracy.
  
  
  BACKGROUND
  The TOPDOM database and the constrained HMMTOP prediction server are available on the page http://topdom.enzim.hu
  
  
  BACKGROUND
  tusi@enzim.hu; lkalmar@enzim.hu.
authors.affiliation: Institue of Enzymology, BRC, Hungarian Academy of Sciences, H-1113 Karolina út 29, Budapest, Hungary. tusi@enzim.hu
authors.forename: Gábor E
authors.initials: GE
authors.lastname: Tusnády
authors.forename: Lajos
authors.initials: L
authors.lastname: Kalmár
authors.forename: Hédi
authors.initials: H
authors.lastname: Hegyi
authors.forename: Péter
authors.initials: P
authors.lastname: Tompa
authors.forename: István
authors.initials: I
authors.lastname: Simon
mesh_terms: D000465:Algorithms; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017124:Conserved Sequence; D003628:Database Management Systems; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods*; D008565:Membrane Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D014584:User-Computer Interface
chemical_list: D008565:Membrane Proteins