A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.
Baumann
Marcus
M
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Baxendale
Ian R
IR
Ley
Steven V
SV
Nikbin
Nikzad
N
Smith
Christopher D
CD
Tierney
Jason P
JP
D001386:Azides / Q000737:chemistry*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D001386:Azides; D002219:Carbamates; D002264:Carboxylic Acids; D014508:Urea; C007523:diphenylphosphorazidate