Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs.
Preliminary studies showed spinosad to be rapidly effective and safe in controlling fleas on dogs. To validate these studies, a clinical trial was undertaken using 470 flea-infested client-owned dogs allocated to receive three monthly treatments with either beef-flavored chewable spinosad tablets (30-60 mg/kg) or selamectin applied according to label instructions. Flea counts 15 days after enrollment were reduced by 98.6% and 90.9% for spinosad- and selamectin-treated dogs, respectively; at 90 days, flea count reductions were 99.9% and 98.9%, respectively. Compared with baseline, all flea reductions were significant (P < .001) for both products and spinosad was significantly (P ≤ .0172) more effective than selamectin at each postenrollment flea count.
Robertson-Plouch
Carol
C
Elanco Animal Health.
Baker
Keith A
KA
Hozak
Rebecca R
RR
Zimmermann
Alan G
AG
Parks
S Craig
SC
Herr
Cory
C
Hart
Liane M
LM
Jay
Jeff
J
Hutchens
Douglas E
DE
Snyder
Daniel E
DE
D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D004338:Drug Combinations; D058267:Flea Infestations / Q000517:prevention & control / Q000662:veterinary*; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets
D004338:Drug Combinations; D007306:Insecticides; D018942:Macrolides; D013607:Tablets; C415329:spinosad