title: A case of lymphomatoid granulomatosis followed for 14 months on the basis of clinical and histological findings.
abstract: Lymphomatoid granulomatosis (LYG) is a systemic granulomatous disease characterized by B-cell proliferation of uncertain malignant potential. It most frequently affects the lungs but also occasionally affects the central nervous system. Its pathophysiology is unclear in numerous respects, thus making it difficult to diagnose and treat. We recently encountered a case of LYG that was followed clinically and histologically for 14 months. A 55-year-old man was hospitalized with multiple brain tumors for which the final diagnosis was not made until the second surgery, 14 months after the first intervention. Following the diagnosis, he was treated with steroid pulse therapy. At present, 3.5 years after the onset of LYG, the patient is in good condition with no signs of tumor recurrence. Although LYG is usually graded on the basis of histological findings, this patient showed no histological changes or any increase in disease grade during the 14-month follow-up period.
authors.affiliation: Department of Neurosurgery, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan. okuda@neuro-s.med.kindai.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okuda
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Akai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kataoka
authors.forename: Mamoru
authors.initials: M
authors.lastname: Taneda
mesh_terms: D000437:Alcoholism / Q000150:complications; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D019635:Neurosurgical Procedures; D014057:Tomography, X-Ray Computed; D014899:Wernicke Encephalopathy / Q000150:complications
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone