title: Nodular regenerative hyperplasia of liver.
abstract: Nodular regenerative hyperplasia of the liver (NRHL) is a very rare cause of portal hypertension and liver failure. The condition is characterized by diffuse micronodular transformation of hepatic parenchyma without fibrous septa between the nodules. We present our experience with a 32-year-old woman who presented with recurrent episodes of upper gastrointestinal bleeding associated with massive splenomegaly who was subsequently found to have NRHL. This article considers the salient aspects of this rare condition, how it affects the patients and the options available in its management. A plea is made for the need for liver biopsy for all patients with portal hypertension especially those being considered for surgery.
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: D
authors.initials: D
authors.lastname: Shelly
authors.forename: M S
authors.initials: MS
authors.lastname: Tevatia
authors.forename: A K
authors.initials: AK
authors.lastname: Praharaj
authors.forename: A
authors.initials: A
authors.lastname: Mehta
authors.forename: S
authors.initials: S
authors.lastname: Harish
authors.forename: V
authors.initials: V
authors.lastname: Baskaran
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis*; D005767:Gastrointestinal Diseases / Q000209:etiology; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis*; D013163:Splenomegaly / Q000209:etiology