title: Inducing photochemical cortical lesions in rat brain.
abstract: In the rat photochemical cortical lesion model described in this unit, an intravascular photochemical reaction induces endothelial damage resulting in platelet aggregation, thrombosis, thrombotic response (secretion of factors by the platelets) and permanent cerebral vascular occlusion. Because thrombosis is produced in pial vessels, the resulting cortical infarct is generally smaller and more reproducible than in the models involving occlusion of the middle cerebral artery. The surgical procedures involved are limited, making this model generally easier to perform and less invasive than most other models of permanent focal ischemia that involve mechanical occlusion of major cerebral arteries.
authors.affiliation: Lilly Research Laboratories, Indianapolis, Indiana, USA.
authors.forename: Marcelle
authors.initials: M
authors.lastname: Bergeron
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D002544:Cerebral Infarction / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000139:chemically induced* / Q000150:complications; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D005260:Female; D007834:Lasers; D008297:Male; D009488:Neurosciences / Q000379:methods*; D017319:Photosensitizing Agents; D010841:Pia Mater / Q000098:blood supply; D051381:Rats; D013927:Thrombosis / Q000150:complications / Q000209:etiology
chemical_list: D017319:Photosensitizing Agents