The underlying mechanisms for development of hypertension in the metabolic syndrome.
High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.
Yanai
Hidekatsu
H
Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan. yanaih@jikei.ac.jp
Tomono
Yoshiharu
Y
Ito
Kumie
K
Furutani
Nobuyuki
N
Yoshida
Hiroshi
H
Tada
Norio
N
D015897:Comorbidity; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology*; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D018384:Oxidative Stress; D012084:Renin-Angiotensin System; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000453:epidemiology; D013564:Sympathetic Nervous System / Q000503:physiopathology