title: Functional classification analysis of somatically mutated genes in human breast and colorectal cancers.
abstract: A recent study published by Sjoblom and colleagues [T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber, D. Mandelker, R.J. Leary, J. Ptak, N. Silliman, S. Szabo, P. Buckhaults, C. Farrell, P. Meeh, S.D. Markowitz, J. Willis, D. Dawson, J.K. Willson, A.F. Gazdar, J. Hartigan, L. Wu, C. Liu, G. Parmigiani, B.H. Park, K.E. Bachman, N. Papadopoulos, B. Vogelstein, K.W. Kinzler, V.E. Velculescu, The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274.] performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific tumor biology. Here we present a systematic analysis of the functional classifications of Sjoblom's "CAN" genes, a subset of these validated mutant genes, that identifies novel organ-specific biological themes and molecular pathways associated with disease-specific etiology. This analysis links four somatically mutated genes associated with diverse oncological types to colorectal and breast cancers through established TGF-beta1-regulated interactions, revealing mechanistic differences in these cancers and providing potential diagnostic and therapeutic targets.
authors.affiliation: Department of Biostatistics and Computational Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115-6084, USA.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Chittenden
authors.forename: Eleanor A
authors.initials: EA
authors.lastname: Howe
authors.forename: Aedin C
authors.initials: AC
authors.lastname: Culhane
authors.forename: Razvan
authors.initials: R
authors.lastname: Sultana
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Taylor
authors.forename: Chris
authors.initials: C
authors.lastname: Holmes
authors.forename: John
authors.initials: J
authors.lastname: Quackenbush
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology; D004252:DNA Mutational Analysis; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D009154:Mutation; D012984:Software; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D053773:Transforming Growth Factor beta1