The role of statins in the prevention of heart failure after acute coronary syndrome.
Patients who have acute coronary syndrome complicated by heart failure have increased short- and long-term morbidity and mortality. Besides the proven action in reducing cardiovascular events and mortality, statins also reduce the risk of developing heart failure after acute coronary syndrome. The pathways responsible for this benefit are likely a result of the "pleiotropic" actions of statins. The ongoing trials of statins in patients who have heart failure will help to further characterize this benefit.
Kumar
Amit
A
University of Massachusetts Medical School, Worcester, MA, USA.
Cannon
Christopher P
CP
D054058:Acute Coronary Syndrome / Q000150:complications*; D006333:Heart Failure / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000150:complications
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors