title: Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.
abstract: Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.
authors.affiliation: Medizinische Klinik II, Universität Würzburg, 97070 Würzburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Mezger
authors.forename: Iwona
authors.initials: I
authors.lastname: Wozniok
authors.forename: Christian
authors.initials: C
authors.lastname: Blockhaus
authors.forename: Oliver
authors.initials: O
authors.lastname: Kurzai
authors.forename: Holger
authors.initials: H
authors.lastname: Hebart
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Juergen
authors.initials: J
authors.lastname: Loeffler
mesh_terms: D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000472:pathogenicity; D002454:Cell Differentiation / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000378:metabolism; D009173:Mycophenolic Acid / Q000009:adverse effects*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D016897:Respiratory Burst / Q000187:drug effects
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D009173:Mycophenolic Acid