Can the night-time atmospheric oxidant NO*3 damage aromatic amino acids?
Reaction of nitrate radicals, NO*3 , with aromatic amino acids leads to irreversible oxidative functionalization at the beta-position or at the aromatic ring, suggesting that this important atmospheric oxidant could potentially cause damage to peptides lining the respiratory tract and may contribute to pollution-derived diseases.
Sigmund
Duanne C E
DC
ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry, BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia.
Wille
Uta
U
D000393:Air Pollutants / Q000138:chemical synthesis / Q000737:chemistry*; D024322:Amino Acids, Aromatic / Q000737:chemistry*; D003624:Darkness; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009566:Nitrates / Q000138:chemical synthesis / Q000737:chemistry*; D016877:Oxidants / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010649:Phenylalanine / Q000737:chemistry; D010777:Photochemistry; D013237:Stereoisomerism; D013997:Time Factors
D000393:Air Pollutants; D024322:Amino Acids, Aromatic; D005609:Free Radicals; D009566:Nitrates; D016877:Oxidants; D010649:Phenylalanine