Infections in lung allograft recipients: ganciclovir era.
BACKGROUND
Infections are common after lung transplantation. This report analyzes infections and associated pathogens identified in 202 lung transplant recipients.


METHODS
Infections were tallied according to sites of infection and associated pathogen(s). Infection events were also categorized by post-operative Days 0 to 100, 101 to 365, and after 365, and normalized to 100 patient-days before and after bronchiolitis obliterans syndrome (BOS).


RESULTS
From November 1990 to November 2005, 202 patients received 208 lung transplants. The follow-up was 702.4 patient-years. A total of 178 lung transplant patients developed 859 infections, with 944 pathogens identified. Infections were in the lung in 559 (65.1%), mucocutaneous (skin, wound, catheter-related, and oral) in 88 (10.2%), in the blood in 85 (9.8%), and in other sites (urine, bowel, eye, and peritoneum) in 127 (14.8%). Most lung pathogens were bacterial (83.6%), and 57.9% were Pseudomonas aeruginosa. Fungi comprised 10.6%, with Aspergillus spp the most common (67.1%) isolate. Cytomegalovirus pneumonitis was seen in 4.3% of respiratory infections. BOS was diagnosed in 87 patients (43.1% of the total). Of all infections seen in the BOS population, there were 0.42 episodes/100 patient-days and 0.70 episodes/100 patient-days before and after BOS, respectively (p = 0.5).


CONCLUSIONS
These data provide an updated infection profile in the ganciclovir era after lung transplantation. When compared with pre-ganciclovir times, post-transplant cytomegalovirus infection incidence has notably declined, with filamentous fungi emerging as prevalent pathogens in its place. Such findings are important for refining management of infections in order to offer more stringent treatment against aggressive pathogens.
Valentine
Vincent G
VG
Multi-Organ Transplant Center, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555-0772, USA. vgvalent@utmb.edu
Bonvillain
Ryan W
RW
Gupta
Meera R
MR
Lombard
Gisele A
GA
LaPlace
Stephanie G
SG
Dhillon
Gundeep S
GS
Wang
Guoshun
G
D000998:Antiviral Agents / Q000627:therapeutic use*; D001989:Bronchiolitis Obliterans / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000453:epidemiology*; D016040:Lung Transplantation; D008297:Male; D011183:Postoperative Complications; D012141:Respiratory Tract Infections / Q000150:complications / Q000382:microbiology / Q000821:virology; D013997:Time Factors; D016896:Treatment Outcome
D000998:Antiviral Agents; D015774:Ganciclovir