title: Orofacial findings and dental treatment in an 8-year-old patient with trisomy 18: a case report.
abstract: Trisomy 18 is characterized by: psychomotor disabilities, dysmorphic features, organ malformations, including mental retardation, growth deficiency, poor motor ability, micrognathia, microcephaly, congenital heart defects, and kidney abnormalities. The oral findings typically observed in these patients are: cleft lip and a high, narrow, and sometimes cleft palate. The degree of severity of the malformations is directly related to life expectancy. Only 5% to 10% of affected infants survive beyond the first year of life. Although trisomy 18 has been widely investigated from a medical standpoint, there is a lack of reports addressing the oral manifestations and dental treatment approach in affected children, presumably due to their shortened life expectancy. The purpose of this article was to present the case of an 8-year-old child diagnosed with trisomy 18 and address the clinical features observed--emphasizing the disease-specific oral, craniofacial, and dental findings. Dental care management of the patient is described.
authors.affiliation: Department of Pediatric Clinics, Faculdade de Odontologia de Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil. amqueiroz@forp.usp.br
authors.forename: Alexandra Mussolino
authors.initials: AM
authors.lastname: de Queiroz
authors.forename: Maria Stella Gaspar Gomes
authors.initials: MS
authors.lastname: Raffaini
authors.forename: Laura Maria
authors.initials: LM
authors.lastname: de Camargo
authors.forename: João Monteiro
authors.initials: JM
authors.lastname: de Pina Neto
authors.forename: Débora Gusmão
authors.initials: DG
authors.lastname: Melo
authors.forename: Raquel A B
authors.initials: RA
authors.lastname: Silva
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D002648:Child; D002887:Chromosomes, Human, Pair 18; D002971:Cleft Lip / Q000235:genetics*; D003730:Dental Care for Persons with Disabilities; D003731:Dental Caries; D005260:Female; D006801:Humans; D008831:Microcephaly / Q000235:genetics; D008844:Micrognathism / Q000235:genetics; D008865:Microstomia / Q000235:genetics; D021362:Palate, Hard / Q000002:abnormalities*; D013577:Syndrome; D014071:Tooth Abnormalities / Q000235:genetics; D014314:Trisomy