TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.
OBJECTIVE
We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ in diabetic and non-diabetic persons.


METHODS
Our analysis included black and white participants from the Atherosclerosis Risk in Communities study who were free of prevalent CVD at baseline and had been genotyped for rs7903146, rs12255372, rs7901695, rs11196205 and rs7895340 (n=13,369). Cox proportional hazard regression was used to estimate the associations between polymorphisms and incident events; logistic and linear regression were used for associations with baseline risk factor levels.


RESULTS
TCF7L2 SNPs were not significantly associated with incident coronary heart disease, ischaemic stroke, CVD, prevalent peripheral artery disease (PAD) or all-cause mortality in the full cohort or when stratified by race.


CONCLUSIONS
In the whole cohort, TCF7L2 SNPs were not associated with incident CVD, all-cause mortality or prevalent PAD. This result suggests that the increased health risk associated with rs7903146 genotype is specific to diabetes.
Bielinski
S J
SJ
Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA. suzetteb@umn.edu
Pankow
J S
JS
Folsom
A R
AR
North
K E
KE
Boerwinkle
E
E
D050197:Atherosclerosis / Q000235:genetics* / Q000401:mortality*; D044383:Black People / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000401:mortality*; D003327:Coronary Disease / Q000235:genetics / Q000401:mortality; D003925:Diabetic Angiopathies / Q000235:genetics* / Q000401:mortality; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D044469:Racial Groups; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein; D044465:White People / Q000235:genetics
D006442:Glycated Hemoglobin; D051820:TCF Transcription Factors; D058118:Transcription Factor 7-Like 2 Protein; C544894:TCF7L2 protein, human