[Mechanisms of cerebral cortical development].
The development of cerebral cortex is regulated by complex mechanisms. Various classes of neurons migrate from the proliferative zones to the cortex according to a spatiotemporal manner. There are two distinct modes of neuronal migration: radial migration and tangential migration. In the benefit of the advancement of research techniques such as in utero electroporation and time-lapse observation of living tissues, more aspects of the cell and molecular mechanisms that control these two migration modes and their roles in the cortical development have been clarified.
Kobayashi
Kazuma
K
Department of Anatomy, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
Nakajima
Kazunori
K
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000502:physiology; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology*; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000502:physiology; D006801:Humans; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D015816:Cell Adhesion Molecules, Neuronal; C115785:DAB1 protein, human; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D000091042:Reelin Protein; C469363:reelin receptor; D012697:Serine Endopeptidases