[Determination of dioxin like polychlorinated biphenyl residues in milk using isotope dilution gas chromatography-ion trap tandem mass spectrometry].
A method for the determination of dioxin like polychlorinated biphenyl (DL-PCB) residues in milk has been developed using high resolution gas chromatography coupled with ion trap mass spectrometry (GC-MS/MS-IT). Analytical procedure consisted of accelerate solvent extraction (ASE), lipid removal with acidic silica and clean-up using anthropogenic isolation column packed with multilayer silica. The analytes were separated on a DB-5 capillary column, detected with multiple reaction monitor mode (MRM) and quantified using internal standard calibration curve of isotope dilution technique. The correlation coefficients of calibration standard solution were above 0. 999 9 for all the DL-PCBs. The recoveries and relative standard deviations of labeled compound solution were in the oranges from 39% to 129% and from 5% to 22%, respectively. The detection limits in the range from 3 to 11 pg/g (fat) were established for the 12 DL-PCBs.
Ding
Gangdou
G
Chinese Academy of Inspection and Quarantine, Beijing, China. dinggangdou@163.com
Li
Xiang
X
Liu
Hanxia
H
Zhong
Weike
W
He
Yinfeng
Y
Zhang
Yao
Y
Sun
Yizhi
Y
D000818:Animals; D004147:Dioxins / Q000737:chemistry*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D007554:Isotopes; D008892:Milk / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000737:chemistry*; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry; D013696:Temperature
D004147:Dioxins; D007554:Isotopes; D011078:Polychlorinated Biphenyls