[Change of IL-4 and IL-6 levels in blood plasma of patients transplanted with allogeneic hematopoietic stem cells determined by protein chip and its relationship with aGVHD].
This study was aimed to explore the relationship between changes of IL-4, IL-6 levels in blood plasma of patients receiving allo-HSCT and aGVHD through dynamical detection. The IL-4 and IL-6 levels in peripheral blood were detected by protein chip and were observed for 10 weeks. The results indicated that the IL-4 level increased rapidly in 1 week after transplantation in aGVHD group and was higher than that of non aGVHD group (p<0.05), while at 7th week after transplantation IL-4 level increased rapidly in non-GVHD group and was higher than that of aGVHD group (p<0.01). There was a significant difference of IL-6 level between these two groups before transplantation. IL-6 level reached peak at 1st week after transplantation in aGVHD group and was higher than that of non-aGVHD group (p<0.01), while IL-6 level was significantly higher in non-aGVHD group than that of aGVHD group at 4th week after transplantation (p<0.01) and at 5th week after transplantation (p<0.05). It is concluded that the levels of IL-4 and IL-6 had been increased rapidly after hematopoietic stem cell transplantation, indicating that aGVHD will occur. The high level of IL-6 before transplantation may be the risk factor of aGVHD occurrence after transplantation. aGVHD may occur later if the blood plasma IL-4 level rises in patients without aGVHD. Therefore, dynamically monitoring IL-4 and IL-6 levels contributes to predict the occurrence of aGVHD.
Jing
Yu
Y
Department of Hematology, The General Hospital of PLA, Beijing 100853, China.
Yu
Li
L
Guo
Guang-Hong
GH
Tian
Ya-Ping
YP
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015847:Interleukin-4 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007938:Leukemia / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D040081:Protein Array Analysis; D014184:Transplantation, Homologous; D055815:Young Adult
D015415:Biomarkers; D015850:Interleukin-6; D015847:Interleukin-4