Palladium-catalyzed three-component coupling of arynes with allylic acetates or halides and terminal alkynes promoted by cuprous iodide.
Benzynes react with allylic acetates or halides and terminal alkynes in the presence of Pd(PPh3)4, CuI and CsF in CH3CN at 50 degrees C for 5 h to give 1-allyl-2-alkynylbenzene derivatives in good to excellent yields.
Bhuvaneswari
Sivakolundu
S
Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Jeganmohan
Masilamani
M
Yang
Ming-Che
MC
Cheng
Chien-Hong
CH
D000085:Acetates / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000480:Alkynes; D000498:Allyl Compounds; D001555:Benzene Derivatives; D006846:Hydrocarbons, Halogenated; D007454:Iodides; D009942:Organometallic Compounds; D010165:Palladium; D003300:Copper; C073870:cuprous iodide