Biphenylene-substituted ruthenocenylphosphine for Suzuki-Miyaura coupling of aryl chlorides.
High activity in the palladium-catalyzed Suzuki-Miyaura reactions of aryl chlorides with arylboronic acids was furnished using biphenylene-substituted di- tert-butylruthenocenylphosphine (R-Phos) as a supporting ligand. Substrate combinations even for the construction of highly hindered tetra- ortho-substituted biaryls can be achieved in good to excellent yields with low catalyst loadings in short reaction times.
Hoshi
Takashi
T
Faculty of Engineering and Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Nishi-ku, Niigata 950-2181, Japan. hoshi@gs.niigata-u.ac.jp
Nakazawa
Taichi
T
Saitoh
Ippei
I
Mori
Ayako
A
Suzuki
Toshio
T
Sakai
Jun-ichi
J
Hagiwara
Hisahiro
H
D001713:Biphenyl Compounds / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D001713:Biphenyl Compounds; D001897:Boronic Acids; D006571:Heterocyclic Compounds; D006843:Hydrocarbons, Chlorinated; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D010165:Palladium; D012428:Ruthenium