Foveal evoked magneto-encephalography features related to the parvocellular pathway.
The aim of this study was to use non-invasive magneto-encephalographic techniques, together with visual stimulus paradigms that can psychophysically separate the M- and P-pathways, to examine the physiological relations of the pathways at the fovea with (1) the magneto-encephalography components M70 and M100 (in latency and amplitude), and (2) the cortical oscillatory activities (alpha, beta, and gamma), respectively. The checkerboard stimuli accompanied with different spatial frequencies (SFs) (0.5 or 4 cycles per degree) were presented (within 2 degrees of the retinal center) to six healthy subjects by using steady-pedestal and pulse paradigms, which could activate distinct populations of M- and P-neurons. SF analyzed brain responses in each paradigm. The results show a consistent trend in M70 and M100 with increased latencies and amplitudes in response to the high SF. Mean while, the beta to gamma activities are apparently enhanced by the stimulus of high SF, especially under pulse paradigm (p = 0.03). In this study, we suggest that M70 can be a good clue to characterize the P-pathway. Moreover, in the frequency analysis, the beta oscillations may serve for more detailed visual information, while the gamma oscillations seem to reflect the signal processing in the P-pathway and with sensitivity to the fovea.
Yang
Chia-Yen
CY
Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Hsieh
Jen-Chuen
JC
Chang
Yin
Y
D000328:Adult; D001921:Brain / Q000502:physiology*; D005074:Evoked Potentials, Visual; D005260:Female; D005584:Fovea Centralis / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D009474:Neurons / Q000502:physiology*; D009991:Oscillometry; D010775:Photic Stimulation / Q000379:methods; D011601:Psychophysics; D011930:Reaction Time; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology*