title: Primate lentivirus capsid sensitivity to TRIM5 proteins.
abstract: Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming retrovirus particles and inhibits subsequent steps of the replication cycle. By substituting human immunodeficiency virus type 1 capsid, we were able to show that a set of divergent primate lentivirus capsids was generally not susceptible to restriction by TRIM5 proteins from higher primates. TRIM5alpha proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins.
authors.affiliation: Aaron Diamond AIDS Research Center and the Rockefeller University, New York, NY 10016, USA.
authors.forename: Zerina
authors.initials: Z
authors.lastname: Kratovac
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Virgen
authors.forename: Frederick
authors.initials: F
authors.lastname: Bibollet-Ruche
authors.forename: Beatrice H
authors.initials: BH
authors.lastname: Hahn
authors.forename: Paul D
authors.initials: PD
authors.lastname: Bieniasz
authors.forename: Theodora
authors.initials: T
authors.lastname: Hatziioannou
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015153:Blotting, Western; D016466:CHO Cells; D036022:Capsid Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005434:Flow Cytometry; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017958:Lentiviruses, Primate / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D011323:Primates / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015183:Restriction Mapping; D016415:Sequence Alignment; D013045:Species Specificity; D044767:Ubiquitin-Protein Ligases
chemical_list: D036022:Capsid Proteins; D011506:Proteins; C482587:TRIM5(alpha) protein, rhesus monkey; D044767:Ubiquitin-Protein Ligases