Thrombocytopenia during levetiracetam therapy.
A 64-year-old patient with symptomatic epilepsy developed thrombocytopenia during treatment with levetiracetam (LEV). As no other medical reason could be evaluated, a medication side effect was postulated. The only new drugs were valproic acid (since 3 weeks) and levetiracetam (since 3 days). After valproic acid medication was ended, thrombocytopenia did not improve and even worsened further. Finally levetiracetam administration was ended and trombocytopenia resolved rapidly and completely within few days.
Meschede
A
A
Department of Neurology, EMA University of Greifswald, Sauerbruchstrasse, 17491 Greifswald, Germany.
Runge
U
U
Sabolek
M
M
D000927:Anticonvulsants / Q000009:adverse effects*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008875:Middle Aged; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D013921:Thrombocytopenia / Q000139:chemically induced*
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam