Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells.
Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis.
Zhang
Zhiyong
Z
Department of Immunology, School of Medicine, Shandong University, Jinan 250012, China.
Cao
Lili
L
Li
Jie
J
Liang
Xiaohong
X
Liu
Yugang
Y
Liu
Hua
H
Du
Juan
J
Qu
Zhonghua
Z
Cui
Min
M
Liu
Suxia
S
Gao
Lifen
L
Ma
Chunhong
C
Zhang
Lining
L
Han
Lihui
L
Sun
Wensheng
W
D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000502:physiology; D023102:Anoikis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D019008:Drug Resistance, Neoplasm; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D014162:Transfection
C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins