title: Aggressive recurrent respiratory papillomatosis in a neonate.
abstract: Recurrent respiratory papillomatosis is the most common benign laryngeal neoplasm in children. We report an infant with widespread papillomatosis at the time of diagnosis and rapidly progressive disease as a neonate. This child did not have the usual risk factors for recurrent respiratory papillomatosis, being the second child born by cesarean section to a mother without history of condyloma. Repeated surgical debulking has been used to control the disease, along with adjuvant therapies that included systemic therapy with an epidermal growth factor receptor inhibitor and intralesional cidofovir. We report our experience with these therapies.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
authors.forename: Myriam
authors.initials: M
authors.lastname: Loyo
authors.forename: Sara I
authors.initials: SI
authors.lastname: Pai
authors.forename: George J
authors.initials: GJ
authors.lastname: Netto
authors.forename: David E
authors.initials: DE
authors.lastname: Tunkel
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000068818:Cetuximab; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D063065:Organophosphonates / Q000627:therapeutic use; D010212:Papilloma / Q000473:pathology* / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D063065:Organophosphonates; D003596:Cytosine; D066246:ErbB Receptors; D000077404:Cidofovir; D000068818:Cetuximab