Correlation of histologic findings on preimplant biopsy with kidney graft survival.
Kidney biopsies are being used to evaluate marginal deceased donor organs, but, the literature on the utility of this practice remains conflicting. We re-examined this issue by performing a multivariate analysis of 597 kidney transplant recipients. The presence of moderate arteriosclerosis and/or moderate arteriolosclerosis (MA), defined as >or=25% luminal compromise, was a significant predictor of graft outcome in standard criteria donors (multivariate, P=0.01) and in expanded criteria donors (ECD) as defined by UNOS criteria (univariate P=0.02). One-, 3-, and 5-year overall allograft survival with MA was 71%, 58%, and 40%, respectively. Increasing degrees of glomerulosclerosis (GS) were associated with earlier graft failure on univariate (P=0.03) but not multivariate analysis (P=0.36). GS>20% and interstitial fibrosis>25% had a low frequency in the material reviewed, likely reflecting our organ utilization practices, and did not have a demonstrable effect on graft outcome. Clinical parameters independently associated with worse graft function were ECD status (P<0.05), retransplantation (P=0.004), recipient age (P<0.05), and delayed graft function (P<0.0001). Donor vascular disease is an independent risk factor for suboptimal graft survival. Great caution should be exercised in the decision to transplant kidneys with moderate arterial and/or arteriolar luminal narrowing.
Kayler
Liise K
LK
Department of Surgery, University of Florida Medical Center, College of Medicine, Gainesville, FL 32610-0286, USA. liisekayler@yahoo.com
Mohanka
Ravi
R
Basu
Amit
A
Shapiro
Ron
R
Randhawa
Parmjeet S
PS
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies