Preclinical models of hepatic encephalopathy.
Hepatic encephalopathy is a multifactorial neuropsychiatric syndrome accompanying acute or chronic liver failure. Techniques for developing animal models of hepatic encephalopathy associated with acute or chronic liver failure, or vascular shunting are illustrated. In addition, the behavioral and biochemical characteristics of these models are described.
Basile
A S
AS
Laboratory of Bio-Organic Chemistry, National Institute of Diabetes and Digestive & Kidney Diseases, NIH, Bethesda, Maryland, USA.
Mullen
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D000818:Animals; D004195:Disease Models, Animal; D005688:Galactosamine / Q000633:toxicity; D006499:Hepatic Artery; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism; D006975:Hypertension, Portal / Q000150:complications; D008026:Ligation / Q000009:adverse effects / Q000379:methods; D017093:Liver Failure / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism; D008297:Male; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013536:Suture Techniques; D013853:Thioacetamide / Q000633:toxicity
D013853:Thioacetamide; D005688:Galactosamine