Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
OBJECTIVE
The underlying genetic component of obesity-related traits is not well understood, and there is limited evidence to support genetic association shared across multiple studies, populations, and environmental contexts. The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort.


METHODS
We selected and genotyped 19 single nucleotide polymorphisms in 10 genes (ADRB2, ADRB3, FTO, GNB3, INSIG2, LEPR, PPARG, TNF, UCP2, and UCP3) that had been previously reported to be associated with an obesity-related quantitative trait.


RESULTS
We observed evidence for association of the A allele of rs9939609 (FTO intron 1) with increased BMI (P = 0.0072 before multiple test correction), baseline BMI (P = 0.0015), longitudinal BMI based on eight surveys from 1983 to 2005 (P = 0.000029), waist circumference (P = 0.0094), and weight (P = 0.021). The increase in average BMI was approximately 0.4 for each additional A allele. We also observed association of the ADRB3 Trp64Arg variant with BMI, waist circumference, percent body fat, weight, fat mass, arm fat area, and arm muscle area (P < 0.05), although the direction of effect is inconsistent with the majority of previous reports.


CONCLUSIONS
Our study confirms that FTO is a common obesity susceptibility gene in Filipinos, with an effect size similar to that seen in samples of European origin.
Marvelle
Amanda F
AF
Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lange
Leslie A
LA
Qin
Li
L
Adair
Linda S
LS
Mohlke
Karen L
KL
D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015331:Cohort Studies; D014644:Genetic Variation; D005838:Genotype; D006306:Health Surveys; D006801:Humans; D008137:Longitudinal Studies; D009752:Nutritional Status; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics; D010679:Philippines / Q000208:ethnology; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human