[Mechanisms underlying changes in functional properties of red cells in acute action of carbon monoxide].
It has been experimentally established that a single impact of carbon mono-oxide in concentration 4000 mg/m3 during 75 minutes (CL50) in rats is accompanied with disturbance of functional activities of blood red cells in the form of a decrease of deformability and an increase of aggregative capacity of erythrocytes which are most evident to the end of the first day after carbon mono-oxide administration. These changes are combined with structural modification and changes in metabolism of erythrocytic membrane. The signs of structural modification of erythrocytic membrane in rats exposed to acute effect of carbon mono-oxide in a mean lethal concentration stay long remaining during elimination of carboxyhemoglobinemia (up to 14-21 days).
Shperling
I A
IA
Novitskiĭ
V V
VV
Riazantseva
N V
NV
Rogov
O A
OA
Tkachenko
S B
SB
Filippova
O N
ON
Saprykina
E V
EV
Aliev
O I
OI
Plotnikov
M B
MB
D000818:Animals; D002248:Carbon Monoxide / Q000633:toxicity*; D002249:Carbon Monoxide Poisoning / Q000097:blood*; D002263:Carboxyhemoglobin / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin