Use of chicken models for the analysis of human disease.
The chicken has been a valuable model organism for genetic analysis since early in the last century. This unit provides an overview of the primary strategic approaches through which the chicken is used as a model for human genetics and disease. These approaches are reviewed with key advantages and disadvantages noted for each. In addition, the chicken offers a model system for several human inherited diseases, both single gene-based and complex traits. This unit briefly describes two such models as examples: autoimmune pathology causing Hashimoto's thyroiditis and sex-linked dwarfism.
Dodgson
Jerry B
JB
Michigan State University, East Lansing, Michigan, USA.
Romanov
Michael N
MN
D000483:Alleles; D000818:Animals; D030801:Animals, Genetically Modified; D002461:Cell Line, Transformed; D002645:Chickens; D004392:Dwarfism / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005822:Genetic Vectors; D005854:Germ Cells; D050031:Hashimoto Disease / Q000235:genetics*; D006801:Humans; D023421:Models, Animal