Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles.
BACKGROUND
Tamoxifen (TAM) a non-steroidal antiestrogen, is widely used in adjuvant therapy for all stages of breast carcinomas and in chemoprevention of high-risk group. TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer. In this context, this study was undertaken to find if co-administration of TAM along with CoRN could alleviate the sole TAM-induced biochemical derangements in postmenopausal women with breast cancer.


METHODS
The vitamin supplementation with TAM was given for a period of 90 days. Blood samples were collected at the base line, 45th and 90th day during the course of treatment. Various blood chemistry profiles were assessed in 78 untreated, sole TAM treated and combinatorial treated group along with 46 age- and sex-matched controls.


RESULTS
A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN.


CONCLUSIONS
TAM on co-administration with CoRN has a favorable impact on various blood chemistry profiles. However, large scale randomized studies over a longer time span are required to ascertain the safety and efficacy of co-administrating antioxidants with conventional chemotherapy.
Yuvaraj
Srinivasan
S
Department of Medical Biochemistry, Dr ALMP-GIBMS, University of Madras, Taramani Campus, Chennai, Tamil Nadu, India.
Premkumar
Vummidi Gridhar
VG
Shanthi
Palanivel
P
Vijayasarathy
Kothandaraman
K
Gangadaran
Sitthu Govindaswamy Dinakaran
SG
Sachdanandam
Panchanatham
P
D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001774:Blood Chemical Analysis; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy*; D019587:Dietary Supplements; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage*; D017698:Postmenopause; D012256:Riboflavin / Q000008:administration & dosage*; D013629:Tamoxifen / Q000627:therapeutic use*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014803:Vitamin B Complex / Q000008:administration & dosage
D018931:Antineoplastic Agents, Hormonal; D045222:Electron Transport Chain Complex Proteins; D008055:Lipids; D013629:Tamoxifen; D014803:Vitamin B Complex; D014451:Ubiquinone; D009525:Niacin; C024989:coenzyme Q10; D012256:Riboflavin