Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis.
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*14 and DRB1*11 bearing haplotypes protect against MS and DRB1*01 and DRB1*10 interact with DRB1*15 to reduce risk of the disease. Recent work in other autoimmune diseases such as rheumatoid arthritis has suggested that maternal non-transmitted protective alleles can also confer disease resistance. In this investigation of 7093 individuals from 1432 MS families, we have analysed the transmission of HLA-DRB1*14,*11,*10 and *01 haplotypes, stratified by sex of parent. No significant transmission differences between mothers and fathers were found, suggesting that non-inherited resistance alleles do not appear to play a role in MS.
Ramagopalan
Sreeram V
SV
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Dyment
David A
DA
Herrera
Blanca M
BM
DeLuca
Gabriele C
GC
Lincoln
Matthew R
MR
Orton
Sarah M
SM
Handunnetthi
Lahiru
L
Chao
Michael J
MJ
Dessa Sadovnick
A
A
Ebers
George C
GC
D000483:Alleles; D005192:Family Health; D005260:Female; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D010290:Parents
D006684:HLA-DR Antigens