title: Impact of musculoskeletal disease on quality of life in long-standing acromegaly.
abstract: OBJECTIVE
  To provide rheumatological assessment of patients with long-standing acromegaly and investigate the impact of musculoskeletal disease on quality of life.
  
  
  METHODS
  Cross-sectional observational study.
  
  
  METHODS
  Fifty-eight patients diagnosed with acromegaly at least 5 years previously were interviewed and examined by a rheumatologist. Each patient completed the short form-36 (SF-36), arthritis impact measurement scales 2 (AIMS2) and acromegaly quality of life questionnaires (AcroQol).
  
  
  RESULTS
  Fifty-two out of 58 (90%) reported musculoskeletal pain, with 29 (50%) reporting neck pain. Hip osteoarthritis was present in 49 (84%) and knee osteoarthritis in 20 (34%). Half the patients (52%) reported sleep disturbance, but only 2 (3.5%) had fibromyalgia. Ten (17.2%) had previously undergone carpal tunnel decompression. Fifty-one (88%) patients had consulted their general practioner and 31 (54%) complementary therapists. SF-36, AIMS2 and AcroQol scores were lower in patients with musculoskeletal pain.
  
  
  CONCLUSIONS
  This study of musculoskeletal problems in patients with acromegaly reports systematic rheumatological examination, use of medical services and quality of life scores. Musculoskeletal problems should be routinely addressed in acromegaly by both endocrinologist and rheumatologist and a multidisciplinary approach taken to management.
authors.affiliation: Department of Rheumatology, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK. anne.miller@noc.anglox.nhs.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Miller
authors.forename: Helen
authors.initials: H
authors.lastname: Doll
authors.forename: Joel
authors.initials: J
authors.lastname: David
authors.forename: John
authors.initials: J
authors.lastname: Wass
mesh_terms: D000172:Acromegaly / Q000453:epidemiology* / Q000503:physiopathology*; D000368:Aged; D002349:Carpal Tunnel Syndrome / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology; D006296:Health Services / Q000706:statistics & numerical data; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000453:epidemiology* / Q000503:physiopathology*; D010146:Pain / Q000453:epidemiology; D015995:Prevalence; D011788:Quality of Life; D012893:Sleep Wake Disorders / Q000453:epidemiology; D011795:Surveys and Questionnaires