title: MR sialography: the effect of a sialogogue and ductal occlusion in volunteers.
abstract: MR sialography using heavily T(2) weighted projection techniques relies upon saliva for image contrast, and the visualization of normal ducts is often limited. Methods used to increase the volume of intraductal saliva during imaging in order to improve duct visualization have not been previously evaluated. The effect of a sialogogue and passive ductal occlusion on the ability to visualize the main and intraglandular salivary gland ducts during MR sialography was investigated. Three-dimensional (3D) T(2) weighted MR sialograms were obtained from 12 healthy volunteers with and without the combined use of a sialogogue and passive ductal occlusion pad adjacent to the parotid duct orifice on one side. Two radiologists (in consensus) subjectively evaluated ductal visualization and image artefacts on the resulting blinded maximum intensity projections. The results demonstrate that main duct visualization was significantly improved (p<0.00001) by this technique, with no significant change seen in image artefacts. Although an improvement in intraglandular duct visualization was noted, this was not statistically significant (p = 0.05). Thus, the use of a sialogogue and passive ductal occlusion improves visualization of the main parotid duct in volunteers undergoing MR sialography. Further optimization and evaluation of this approach should lead to improvements in the MR sialography examination of patients.
authors.affiliation: Department of Radiology, University of Cambridge and Addenbrooke's Hospital, Box 219, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ UK.
authors.forename: J
authors.initials: J
authors.lastname: Hugill
authors.forename: E
authors.initials: E
authors.lastname: Sala
authors.forename: K G
authors.initials: KG
authors.lastname: Hollingsworth
authors.forename: D J
authors.initials: DJ
authors.lastname: Lomas
mesh_terms: D000328:Adult; D016477:Artifacts; D003250:Constriction; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000033:anatomy & histology*; D010865:Pilot Projects; D018987:Salivary Ducts / Q000033:anatomy & histology*; D012796:Sialography / Q000379:methods*