Synthesis of platensimycin analogues and their antibiotic potency.
Platensimycin is a natural product isolated from various strains of Streptomyces platensis which exhibits antimicrobial activity against Gram positive bacteria, including vancomycin- and linezolide-resistant species. Analogues of platensimycin were synthesized from 3-aminobenzoic acid or other aniline derivatives and several alkyl- and aryl-carboxylic acids. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi.
Krauss
Jürgen
J
Pharmaceutical Chemistry, Department of Pharmacy, Center of Drug Research, LMU Munich, Munich, Germany. hjkra@cup.uni-muenchen.de
Knorr
Veronika
V
Manhardt
Vera
V
Scheffels
Stefanie
S
Bracher
Franz
F
D000218:Adamantane / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015169:Colony Count, Microbial; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D062365:Aminobenzoates; D000813:Anilides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000218:Adamantane; C510909:platensimycin