Amelioration of experimental autoimmune encephalomyelitis by BLyS autovaccine.
The B-lymphocyte stimulator (BLyS) is implicated in various pathophysiological processes. The overexpression of BLyS has been observed in some human diseases, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. This feature suggests that BLyS may be a therapeutic target for some human autoimmune diseases. We developed a therapeutic vaccine by coupling a tetanus toxoid T-helper cell epitope with the C-terminal of BLyS (TT-BLyS). This vaccine can induce high titers of neutralizing antibodies against BLyS in an animal model; the antibody has markedly protective effects on experimental autoimmune encephalomyelitis in rats, which is induced by inoculation of spinal cord homogenate. Our data suggest that the BLyS autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with the production of BLyS.
Xue
Xiaochang
X
Biotechnology Center of The Fourth Military Medical University, 17 Changle West Road, 710032 Xi'an, People's Republic of China.
Feng
Guodong
G
Li
Meng
M
Qin
Xin
X
Wu
Shouzhen
S
Zhang
Cun
C
You
Yanjie
Y
Wang
Weihua
W
Jiang
Changli
C
Liu
Yan
Y
Zhu
Wenhua
W
Ran
Yonggang
Y
Zhang
Zhen
Z
Yan
Zhen
Z
Han
Wei
W
Zhang
Yingqi
Y
D000818:Animals; D001323:Autoantibodies / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D001324:Autoantigens / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D053264:B-Cell Activating Factor / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D001522:Behavior, Animal; D002531:Cerebellum / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000502:physiology; D009500:Neutralization Tests; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000473:pathology; D014612:Vaccines / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use
D001323:Autoantibodies; D001324:Autoantigens; D053264:B-Cell Activating Factor; D014612:Vaccines; D014614:Vaccines, Synthetic; D007073:Immunoglobulin E; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases