title: Microbial transformation of oleanolic acid by Fusarium lini and alpha-glucosidase inhibitory activity of its transformed products.
abstract: The biotransformation of a pentacyclic triterpene, oleanolic acid (1), with Fusarium lini afforded two oxidative metabolites, 2alpha,3beta-dihydroxyolean-12-en-28-oic acid (2), and 2alpha,3beta,11beta-trihydroxyolean-12-en-28-oic acid (3). Metabolite 3 was found to be a new compound. The structures were characterized on the basis of spectroscopic studies. These metabolites exhibited a potent inhibition of alpha-glucosidase enzyme.
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan. hej@cyber.net.pk
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Iffat
authors.initials: I
authors.lastname: Batool
authors.forename: Shamsun Nahar
authors.initials: SN
authors.lastname: Khan
authors.forename: Nighat
authors.initials: N
authors.lastname: Sultana
authors.forename: S Adnan Ali
authors.initials: SA
authors.lastname: Shah
authors.forename: Atta
authors.initials: A
authors.lastname: Ur-Rahman
mesh_terms: D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D005670:Fusarium / Q000378:metabolism*; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D009904:Optical Rotation; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid; D000520:alpha-Glucosidases