title: Invasive pulmonary infection due to Trichoderma longibrachiatum mimicking invasive Aspergillosis in a neutropenic patient successfully treated with voriconazole combined with caspofungin.
abstract: Trichoderma longibrachiatum, a filamentous fungus, was recently described as an emerging pathogen in immunocompromised patients. Here, we report the first case, to our knowledge, of isolated invasive lung infection by T. longibrachiatum in a patient with hematologic malignancy. The infection mimicked invasive pulmonary aspergillosis and was successfully treated with a combination of voriconazole and caspofungin.
authors.affiliation: Department of Parasitology-Mycology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alanio
authors.forename: Benoît
authors.initials: B
authors.lastname: Brethon
authors.forename: Martine
authors.initials: M
authors.lastname: Feuilhade de Chauvin
authors.forename: Eric
authors.initials: E
authors.lastname: de Kerviler
authors.forename: Thierry
authors.initials: T
authors.lastname: Leblanc
authors.forename: Claire
authors.initials: C
authors.lastname: Lacroix
authors.forename: André
authors.initials: A
authors.lastname: Baruchel
authors.forename: Jean
authors.initials: J
authors.lastname: Menotti
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077336:Caspofungin; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000627:therapeutic use*; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D055666:Lipopeptides; D008297:Male; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications*; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use*; D014242:Trichoderma / Q000302:isolation & purification*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole