title: A new method of providing pulsatile flow in a centrifugal pump: assessment of pulsatility using a mock circulatory system.
abstract: Previous studies have demonstrated the potential advantages of pulsatile flow as compared with continuous flow. However, to date, physiologic pumps have been technically complex and their application has therefore remained in the experimental field. We have developed a new type of centrifugal pump, which can provide pulsatile as well as continuous flow. The inner wall of a centrifugal pump is pulsed by means of a flexible membrane, which can be accurately controlled by means of either a hydraulic or pneumatic driver. The aim of this study was to assess the hydraulic behavior of the new pump in terms of surplus hemodynamic energy (SHE). We conducted experiments using a mock circulatory system including a membrane oxygenator. No differences were found in the pressure-flow characteristics between the new pump and a conventional centrifugal pump, suggesting that the inclusion of the flexible membrane does not alter hydraulic performance. The value of SHE rose when systolic volume was increased. However, SHE dropped when the percentage of ejection time was reduced and also when the continuous flow (programmed by the centrifugal console) increased. Mean flow matched well with the continuous flow set by the centrifugal console, that is, the pulsatile component of the flow was exclusively controlled by the pulsatile console, and was therefore independent of the continuous flow programmed by the centrifugal console. The pulsatility of the new pump was approximately 25% of that created with a truly pulsatile pump.
authors.affiliation: Cardiovascular Surgery Department, Clínica Universitaria, University of Navarra, Pamplona, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Herreros
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Berjano
authors.forename: Laura
authors.initials: L
authors.lastname: Sales-Nebot
authors.forename: Pedro
authors.initials: P
authors.lastname: Más
authors.forename: Irene
authors.initials: I
authors.lastname: Calvo
authors.forename: Stefano
authors.initials: S
authors.lastname: Mastrobuoni
authors.forename: Salvador
authors.initials: S
authors.lastname: Mercé
mesh_terms: D006439:Hemodynamics; D006801:Humans; D008567:Membranes, Artificial; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012826:Silicone Elastomers / Q000737:chemistry; D013318:Stroke Volume
chemical_list: D008567:Membranes, Artificial; D012826:Silicone Elastomers