title: On the performance of an implicit-explicit Runge-Kutta method in models of cardiac electrical activity.
abstract: Mathematical models of electric activity in cardiac tissue are becoming increasingly powerful tools in the study of cardiac arrhythmias. Considered here are mathematical models based on ordinary differential equations (ODEs) that describe the ionic currents at the myocardial cell level. Generating an efficient numerical solution of these ODEs is a challenging task, and, in fact, the physiological accuracy of tissue-scale models is often limited by the efficiency of the numerical solution process. In this paper, we examine the efficiency of the numerical solution of four cardiac electrophysiological models using implicit--explicit Runge-Kutta (IMEX-RK) splitting methods. We find that variable step-size implementations of IMEX-RK methods (ARK3 and ARK5) that take advantage of Jacobian structure clearly outperform the methods commonly used in practice.
authors.affiliation: Department of Computer Science University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A9, Canada. spiteri@cs.usask.ca
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Spiteri
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Dean
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*; D009716:Numerical Analysis, Computer-Assisted; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D007473:Ion Channels