title: Cytochrome c assembly: a tale of ever increasing variation and mystery?
abstract: Formation of cytochromes c requires a deceptively simple post-translational modification, the formation of two thioether bonds (or rarely one) between the thiol groups of two cysteine residues found in a CXXCH motif (with some occasional variations) and the vinyl groups of heme. There are three partially characterised systems for facilitating this post-translational modification; within these systems there is also variation. In addition, there are clear indications for two other distinct systems. Here some of the current issues in understanding the systems are analysed.
authors.affiliation: Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. stuart.ferguson@bioch.ox.ac.uk
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Ferguson
authors.forename: Julie M
authors.initials: JM
authors.lastname: Stevens
authors.forename: James W A
authors.initials: JW
authors.lastname: Allen
authors.forename: Ian B
authors.initials: IB
authors.lastname: Robertson
mesh_terms: D000595:Amino Acid Sequence; D003545:Cysteine / Q000378:metabolism; D045304:Cytochromes c / Q000235:genetics* / Q000378:metabolism*; D004579:Electron Transport; D014644:Genetic Variation; D006801:Humans; D008190:Lyases / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013440:Sulfides / Q000378:metabolism
chemical_list: D013440:Sulfides; D045304:Cytochromes c; D008190:Lyases; D003545:Cysteine