title: Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem.
abstract: Of 393 isolates of Streptococcus pneumoniae from U.S. children collected in 2005-2006, nonvaccine serotypes accounted for 89.1%, with serotype 19A the most prevalent, representing 30.5% of all isolates. The MIC(90) of faropenem against serotype 19A isolates was 1 mug/ml, compared to > or =8 microg/ml against amoxicillin/clavulanate, cefdinir, cefuroxime axetil, and azithromycin.
authors.affiliation: Replidyne Inc., 1450 Infinite Drive, Louisville, CO 80027, USA. icritchley@replidyne.com
authors.forename: Ian A
authors.initials: IA
authors.lastname: Critchley
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: Steven D
authors.initials: SD
authors.lastname: Brown
authors.forename: Maria M
authors.initials: MM
authors.lastname: Traczewski
authors.forename: Glenn S
authors.initials: GS
authors.lastname: Tillotson
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Janjic
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity; D014481:United States; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C107057:fropenem