The PPARgamma coding region and its role in visceral obesity.
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand activated transcription factor, plays many essential roles of biological function in higher organisms. The PPARgamma is mainly expressed in adipose tissue. It regulates the transcriptional activity of genes by binding with other transcription factor. The PPARgamma coding region has been found to be closest to that of monkey in ours and other research groups. Thus, monkey is a more suitable animal model for future PPARgamma studying, although mice and rat are frequently being used. The PPARgamma is involved in regulating alterations of adipose tissue masses result from changes in mature adipocyte size and/or number through a complex interplay process called adipogenesis. However, the role of PPARgamma in negatively regulating the process of adipogenesis remains unclear. This review may help we investigate the differential expression of key transcription factor in adipose tissue in response to visceral obesity-induced diet in vivo. The study may also provide valuable information to define a more appropriate physiological condition in adipogenesis which may help to prevent diseases cause by negative regulation of the transcription factors in adipose tissue.
Boon Yin
Khoo
K
School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. kboonyin@yahoo.com
Najimudin
Nazalan
N
Muhammad
Tengku Sifzizul Tengku
TS
D050156:Adipogenesis / Q000235:genetics*; D000818:Animals; D002417:Cattle; D006224:Cricetinae; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D000882:Haplorhini / Q000235:genetics; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D051379:Mice; D009765:Obesity / Q000235:genetics*; D016366:Open Reading Frames; D047495:PPAR gamma / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D011817:Rabbits; D051381:Rats
D047495:PPAR gamma