title: Twin pregnancy in a patient of chronic myeloid leukemia on imatinib therapy.
abstract: Imatinib is a tyrosine kinase inhibitor and is now used regularly in chronic myeloid leukaemia therapy in chronic phase with great success. This drug due its very nature of action is suspected to be teratogenic hence the patients are counseled not to get pregnant while on this drug. However in world literature few normal pregnancies have been reported in patients on Imatinib therapy, though no twin pregnancy has been reported on this medication. We report here the birth of normal mono-ovular mono-chorionic twin while the patient is on imatinib during conception and early pregnancy for chronic myeloid leukaemia.
authors.affiliation: JC Patel Department of Hematology, KEM Hospital, Mumbai, India.
authors.forename: V
authors.initials: V
authors.lastname: Meera
authors.forename: Farah
authors.initials: F
authors.lastname: Jijina
authors.forename: Mitu
authors.initials: M
authors.lastname: Shrikande
authors.forename: Manisha
authors.initials: M
authors.lastname: Madkaikar
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D010879:Piperazines / Q000627:therapeutic use*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D011743:Pyrimidines / Q000627:therapeutic use*; D014427:Twins
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate