Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor.
Markus
Michelle A
MA
Structural Biology and Computational Chemistry, Chemical and Screening Sciences, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA. mmarkus@wyeth.com
Dwyer
Brian
B
Wolfrom
Scott
S
Li
Jianchang
J
Li
Wei
W
Malakian
Karl
K
Wilhelm
James
J
Tsao
Désirée H H
DH
D020134:Catalytic Domain; D006801:Humans; D053508:Matrix Metalloproteinase 12 / Q000737:chemistry*; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011480:Protease Inhibitors / Q000737:chemistry*; D011487:Protein Conformation; D012996:Solutions; D013876:Thiophenes / Q000737:chemistry*; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry
C530741:N-(dibenzo(b,d)thiophene-3-sulfonyl)valine; D011480:Protease Inhibitors; D012996:Solutions; D013876:Thiophenes; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12; D014633:Valine