Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells.
Glycyrrhetinic acid (GA) is the active metabolite of glycyrrhizic acid, one of the components of liquorice extract. It has been shown to possess anti-inflammatory activity and to inhibit hepatic tumour growth. In this preliminary study, we have shown that GA could significantly reduce the rate of proliferation of LNCaP androgen dependent prostate cancer cells, whereas it had no effect on proliferation of PC3 and DU145 androgen-independent prostate cancer cells. Additionally, GA could significantly reduce the production of prostate-specific antigen by LNCaP cells maintained in-vitro. This study provides a sound platform for further investigation.
Hawthorne
Susan
S
School of Pharmacy, Medical Biology Centre, Queens University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. s.hawthorne@qub.ac.uk
Gallagher
Sandra
S
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D010936:Plant Extracts; D017430:Prostate-Specific Antigen; D006034:Glycyrrhetinic Acid