[Specific disturbances of psychomotor development in children with thymomegaly].
Ninety children, aged from 2 month to 3 years, with thymomegaly and 25 aged-matched controls were studied. Most children with thymomegaly had disturbances of psychomotor development. Depending on their types, the cohort of children was stratified into 4 subgroups: 1st - 36 patients (40%) with schizotypal signs; 2nd - 30 hyperactive children (33%); 3rd - 19 children with hyperthymia signs (21%); 4th - 5 normal children (6%). The deviations of locomotion and psychiatric development were correlated with the extent of thymus enlargement and activation of innate and adaptive immunity.
Ignat'eva
O N
ON
Kuz'menko
L G
LG
Kozlovskaia
G V
GV
Kliushnik
T P
TP
D015551:Autoimmunity / Q000502:physiology*; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D020932:Nerve Growth Factor / Q000097:blood / Q000276:immunology; D010196:Pancreatic Elastase / Q000097:blood / Q000276:immunology; D011379:Prognosis; D011596:Psychomotor Disorders / Q000097:blood / Q000276:immunology / Q000523:psychology*; D011597:Psychomotor Performance / Q000502:physiology*; D012720:Severity of Illness Index; D013950:Thymus Gland / Q000002:abnormalities*; D000515:alpha 1-Antitrypsin / Q000097:blood
D000515:alpha 1-Antitrypsin; D020932:Nerve Growth Factor; D010196:Pancreatic Elastase