title: A very rare cause of virilization in childhood: ovarian Leydig cell tumor.
abstract: Virilization in childhood results from an adrenal and/or ovarian disorder. These children usually present with hyperandrogenism: acne, deepening voice, abnormal hair growth, cliteromegaly. Ovarian Leydig cell tumor is a very rare cause of hyperandrogenism in childhood. They are usually benign and surgical treatment is usually curative if the tumor is limited to the ovaries. We present the youngest case of ovarian Leydig cell tumor reported in the literature who presented with hyperandrogenism that was satisfactorily resolved after resective surgery. Rare causes of virilization should be investigated with special attention paid to tumoral disease in the differential diagnosis.
authors.affiliation: Department of Pediatrics, Dişkapi Children's Hospital, Ankara, Turkey. petekarhan@yahoo.com.tr
authors.forename: Ebru
authors.initials: E
authors.lastname: Arhan
authors.forename: Ergun
authors.initials: E
authors.lastname: Cetinkaya
authors.forename: Zehra
authors.initials: Z
authors.lastname: Aycan
authors.forename: Ayşe Tana
authors.initials: AT
authors.lastname: Aslan
authors.forename: Hüsniye
authors.initials: H
authors.lastname: Yücel
authors.forename: Sadi
authors.initials: S
authors.lastname: Vidinlisan
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D007984:Leydig Cell Tumor / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014770:Virilism / Q000209:etiology*