title: Association between salivary flow rates, oral symptoms, and oral mucosal status.
abstract: OBJECTIVE
  To investigate the association of salivary flow rates with oral symptoms and oral mucosal status.
  
  
  METHODS
  The study population included 462 Israeli subjects attending a xerostomia clinic. After patient history and oral mucosal examination, major gland sialometry, and complementary tests, patients were divided into 6 groups: drug-induced salivary gland hypofunction (SGH), Sjögren syndrome (SS), radiation-induced SGH, idiopathic SGH, xerostomia without SGH, and control.
  
  
  RESULTS
  Oral mucosal alterations were more prevalent in all SGH groups than in the control group. Oral symptoms (except speech impairment) were more frequent in all SGH groups. The postradiation group showed the highest frequency of oral mucosal alterations and of swallowing and mastication complaints. Individuals complaining of xerostomia (compared with those who did not) displayed lower major salivary gland flow rates and a higher frequency of oral mucosal alterations
  
  
  CONCLUSIONS
  Presence of oral mucosal alterations may help but are not enough to identify patients for further evaluation of SGH. Difficulties in mastication and swallowing are most specifically related to advanced SGH.
authors.affiliation: Institute of Pathology, Rabin Medical Center, Petah-Tiqva, Tel-Aviv, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
authors.forename: Limor
authors.initials: L
authors.lastname: Zuk-Paz
authors.forename: Andy
authors.initials: A
authors.lastname: Wolff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003679:Deglutition / Q000502:physiology / Q000528:radiation effects; D005260:Female; D006801:Humans; D008297:Male; D008409:Mastication / Q000502:physiology / Q000528:radiation effects; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D009061:Mouth Mucosa / Q000187:drug effects / Q000503:physiopathology* / Q000528:radiation effects; D010306:Parotid Gland / Q000378:metabolism; D011832:Radiation Injuries / Q000209:etiology / Q000503:physiopathology; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate / Q000502:physiology; D012859:Sjogren's Syndrome / Q000503:physiopathology; D013361:Sublingual Gland / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism; D014987:Xerostomia / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*