title: Verteporfin photodynamic therapy for anterior segment neovascularization secondary to ischaemic central retinal vein occlusion.
abstract: OBJECTIVE
  To evaluate the efficacy of photodynamic therapy (PDT) with verteporfin for anterior segment neovascularizations (ASNVs) in patients affected by ischaemic form of central retinal vein occlusion (CRVO).
  
  
  METHODS
  Prospective non-comparative case series including 10 consecutive patients (10 eyes) affected by ischaemic CRVO. Main outcome measure was the obliteration of ASNV.
  
  
  RESULTS
  One month after PDT, biomicroscopic examination showed partial obliteration of iris new vessels and complete closure of angle neovascularization. Iris fluorescein angiography performed 1 week after treatment showed partial closure of the iris new vessels with no evidence of leakage in the late phases. During the subsequent examinations, a partial reopening of the iris and angle new vessels in association with dye leakage on fluorescein angiography was evident. In any case, the fluorescein leakage turned out to be still reduced with respect to the baseline aspects.
  
  
  CONCLUSIONS
  Our results show that PDT with verteporfin can partially obliterate ASNVs in eyes affected by ischaemic CRVO preventing from the evolution towards advanced stages of neovascular glaucoma, but is not effective in cases with complete angle synechial closure.
authors.affiliation: Eye Clinic, Azienda Ospedaliero-University of Trieste, Trieste, Italy. maubp@yahoo.it
authors.forename: Maurizio Battaglia
authors.initials: MB
authors.lastname: Parodi
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Iacono
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ravalico
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment / Q000098:blood supply*; D001808:Blood Vessels / Q000187:drug effects; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000098:blood supply; D007511:Ischemia / Q000150:complications* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000150:complications*; D016896:Treatment Outcome; D000077362:Verteporfin
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin