title: Ca pre-rinse greatly increases plaque and plaque fluid F.
abstract: Previous studies demonstrated that a Ca pre-treatment greatly increases salivary F from a subsequent NaF rinse. This study examines if these increases are found in plaque and plaque fluid F. Thirteen individuals accumulated plaque before rinsing with: (1) 12 mmol/L NaF (228 microg/g F), (2) 150 mmol/L Ca rinse, or (3) the Ca rinse followed by the F rinse. One hr later, plaque samples were collected, the plaque fluid was recovered, and the plaque residues were extracted 5 times with pH 6.8 or pH 4.8 buffers, and then by acid. The F in each extract after the Ca rinse/F rinse greatly exceeded the corresponding F from the NaF rinse. Consequently, the Ca rinse/F rinse increased the total plaque F and the plaque fluid F by 12x and 5x, compared with the NaF rinse alone. These and the previous salivary results suggest that a Ca pre-treatment may increase the cariostatic effects of topical F agents.
authors.affiliation: American Dental Association Foundation, Paffenbarger Research Center, 100 Bureau Drive Stop 8546, National Institute of Standards and Technology, Gaithersburg, MD 20899-8546, USA. jvogel@nist.gov
authors.forename: G L
authors.initials: GL
authors.lastname: Vogel
authors.forename: G E
authors.initials: GE
authors.lastname: Schumacher
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: C M
authors.initials: CM
authors.lastname: Carey
mesh_terms: D000704:Analysis of Variance; D002118:Calcium / Q000008:administration & dosage*; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005457:Fluoridation; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D009067:Mouthwashes / Q000008:administration & dosage*; D011292:Premedication; D012463:Saliva / Q000378:metabolism; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D009067:Mouthwashes; D002118:Calcium