Chromatin organization in relation to the nuclear periphery.
In the limited space of the nucleus, chromatin is organized in a dynamic and non-random manner. Three ways of chromatin organization are compaction, formation of loops and localization within the nucleus. To study chromatin localization it is most convenient to use the nuclear envelope as a fixed viewpoint. Peripheral chromatin has both been described as silent chromatin, interacting with the nuclear lamina, and active chromatin, interacting with nuclear pore proteins. Current data indicate that the nuclear envelope is a reader as well as a writer of chromatin state, and that its influence is not limited to the nuclear periphery.
Kalverda
Bernike
B
Department of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Röling
Michael D
MD
Fornerod
Maarten
M
D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D020868:Gene Silencing; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure; D034881:Nuclear Lamina / Q000378:metabolism / Q000648:ultrastructure; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism
D002843:Chromatin; D028861:Nuclear Pore Complex Proteins