title: Osmium carbonyl clusters: a new class of apoptosis inducing agents.
abstract: Osmium carbonyl clusters, especially the cluster [Os(3)(CO)(10)(NCCH(3))(2)], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number of morphological and apoptosis assays, all of which pointed to the induction of apoptosis.
authors.affiliation: Department of Chemistry, National University of Singapore, Kent Ridge, Singapore 117543, Singapore.
authors.forename: Kien Voon
authors.initials: KV
authors.lastname: Kong
authors.forename: Weng Kee
authors.initials: WK
authors.lastname: Leong
authors.forename: Swee Phyaw
authors.initials: SP
authors.lastname: Ng
authors.forename: Thanh Hung
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Lina H K
authors.initials: LH
authors.lastname: Lim
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D017892:Osmium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D017892:Osmium Compounds