Protease signaling to G protein-coupled receptors: implications for inflammation and pain.
Proteases, like thrombin, trypsin, cathepsins, or tryptase, can signal to cells by cleaving in a specific manner, a family of G protein-coupled receptors, the protease-activated receptors (PARs). Proteases cleave the extracellular N-terminal domain of PARs to reveal tethered ligand domains that bind to and activate the receptors. Recent evidence has supported the involvement of PARs in inflammation and pain. Activation of PAR(1), PAR(2), and PAR(4) either by proteinases or by selective agonists causes inflammation inducing most of the cardinal signs of inflammation: swelling, redness, and pain. Recent studies suggest a crucial role for the different PARs in innate immune response. The role of PARs in the activation of pain pathways appears to be dual. Subinflammatory doses of PAR(2) agonists induce hyperalgesia and allodynia, and PAR(2) activation has been implicated in the generation of inflammatory hyperalgesia. In contrast, subinflammatory doses of PAR(1) or PAR(4) increase nociceptive threshold, inhibiting inflammatory hyperalgesia, thereby acting as analgesic mediators. PARs have to be considered as an additional subclass of G protein-coupled receptors that are active participants to inflammation and pain responses and that could constitute potential novel therapeutic targets.
Dale
Camila
C
Université Toulouse III Paul Sabatier, Toulouse, France.
Vergnolle
Nathalie
N
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000503:physiopathology*; D008954:Models, Biological; D010146:Pain / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000276:immunology / Q000502:physiology*; D044462:Receptors, Proteinase-Activated / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D043562:Receptors, G-Protein-Coupled; D044462:Receptors, Proteinase-Activated; D010447:Peptide Hydrolases