title: Spontaneous compartment syndrome in association with simvastatin-induced myositis.
abstract: Compartment syndrome as a result of simvastatin-induced myositis is extremely rare. This case discusses a patient with spontaneous onset compartment syndrome that necessitated four-compartment fasciotomy. A thorough investigation into its cause highlighted statin-induced myositis as the most likely aetiological agent. When investigating a patient with unexplained spontaneous compartment syndrome it is important to consider drug-induced myositis. This case reinforces the difficulty faced in diagnosing spontaneous compartment syndrome.
authors.affiliation: Department of Orthopaedics, Edinburgh Royal Infirmary, Little France, Dalkeith Road, Edinburgh EH16 4SU, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Walker
authors.forename: G H
authors.initials: GH
authors.lastname: Smith
authors.forename: M S
authors.initials: MS
authors.lastname: Gaston
authors.forename: C M
authors.initials: CM
authors.lastname: Robinson
mesh_terms: D003161:Compartment Syndromes / Q000209:etiology* / Q000601:surgery; D000071938:Fasciotomy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D007866:Leg; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000139:chemically induced / Q000150:complications*; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin