Case of adult T-cell leukemia with pulmonary involvement presenting as nodular shadows.
A 60-year-old man with a diagnosis of smoldering adult T-cell leukemia (ATL) had been treated successfully for 4 years with psoralen and ultraviolet A therapy, gamma-interferon, oral etoposide and sobuzoxane. He subsequently developed rapidly-growing skin nodules over his entire body. Chest X-ray and thoracic computed tomography showed nodular shadows in the right lower lung field and nodules in both lower lung lobes. Despite combined chemotherapy, he died. Upon autopsy, numerous nodules were found in the bilateral lower lobes; microscopically, the nodules were diffusely infiltrated by ATL cells. Our review of the published work found only two previously reported cases of ATL with pulmonary involvement manifested as nodular shadows. Herein, we present details on the third case.
Oyama
Kimitaka
K
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, Japan. k.oyama@kagoderma.com
Kanekura
Takuro
T
Yoshii
Noriko
N
Yonekura
Kentaro
K
Mera
Kentaro
K
Hirayama
Yoshikazu
Y
Umekita
Yoshihisa
Y
Yoshida
Hiroki
H
Umemura
Yoshiro
Y
Kanzaki
Tamotsu
T
D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000000981:diagnostic imaging* / Q000628:therapy; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy