Recent antiviral strategies against human coronavirus-related respiratory illnesses.
OBJECTIVE
The main purpose of this review is to summarize the current research (2006-2007) concerning the development of novel anticoronaviral strategies and compounds.


RESULTS
Recent research led to the identification of several novel agents inhibiting coronaviral replication. The most promising compounds include carbohydrate-binding agents, neutralizing antibodies and drugs targeting a coronaviral envelope protein.


CONCLUSIONS
Although initial outbreaks of coronavirus that causes severe acute respiratory syndrome (SARS-CoV) were controlled by public health measures, the development of vaccines and antiviral agents for SARS-CoV is essential for improving control and treatment of future outbreaks. Four years after the SARS-CoV epidemic, several compounds with an anticoronaviral activity have been identified.
Golda
Anna
A
Microbiology Department, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Pyrc
Krzysztof
K
D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018352:Coronavirus Infections / Q000188:drug therapy*; D006801:Humans; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000821:virology*
D000998:Antiviral Agents