title: Comparative genomic hybridization (CGH) analysis of chromosomal aberrations in Iranian patients with invasive ductal carcinoma breast cancer.
abstract: BACKGROUND
  Breast cancer is one of the most common cancers in women; however, due to the complexity of chromosomal changes, limited data are available regarding chromosomal constitution.
  
  
  METHODS
  In this study, Comparative Genomic Hybridization (CGH) was used on 16 Iranian patients diagnosed with invasive ductal breast carcinomas.
  
  
  RESULTS
  12 samples had abnormal CGH results (75%), including 21 types of chromosomal imbalance. The most prevalent were chromosomal gain of +1q, +17q, +8q and chromosomal loss of -13q. All three cases with DNA loss at chromosome 13q (-13q) had lymph node metastasis.
  
  
  CONCLUSIONS
  CGH is able to detect chromosomal abnormalities which are difficult to identify by conventional cytogenetic techniques. More studies on a larger sample size may help to confirm or rule out any possible correlation between 13q monosomy and lymph node metastasis, which could result in establishing new strategies for prevention and early detection of invasive breast tumors.
authors.affiliation: Dept of Genomics, Cancer Institute Research Center, Tehran University of Medical Sciences, Tehran, Iran. saeed@ghaffari.org
authors.forename: Saeed R
authors.initials: SR
authors.lastname: Ghaffari
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Sabokbar
authors.forename: Peyman Noshiravan
authors.initials: PN
authors.lastname: Pour
authors.forename: Jila
authors.initials: J
authors.lastname: Dastan
authors.forename: Farhad
authors.initials: F
authors.lastname: Mehrkhani
authors.forename: Solmaz
authors.initials: S
authors.lastname: Shoraka
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mohagheghi
authors.forename: Farrokh
authors.initials: F
authors.lastname: Tirgari
authors.forename: Alireza
authors.initials: A
authors.lastname: Mosavi-Jarrahi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D055028:Comparative Genomic Hybridization / Q000379:methods*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017404:In Situ Hybridization, Fluorescence; D007492:Iran / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm