Comparative genomics and function analysis on BI1 family.
Bax inhibitor-1 (BI1) family contains six known genes in human. Some members of BI1 family have been proved to play important roles in cell death. Here we discuss the similarities and differences among the members of BI1 family by comparative genomics and proteomics, and report here the discovery of a novel member, tmbim1b, in Bos taurus. BI1 family is evolutionarily conserved as integral membrane proteins containing multiple membrane-spanning segments and predominantly localized to intracellular membranes, similar to Bcl-2 family proteins. They share multiple motifs and transcriptional factors within the promoter and the coding regions. They may represent regulators of cell death pathways, which are concluded from structure conservation of BI1 family.
Zhou
Jinhua
J
Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan, Hubei, PR China.
Zhu
Tao
T
Hu
Chunxia
C
Li
Hongyu
H
Chen
Gang
G
Xu
Gang
G
Wang
Shixuan
S
Zhou
Jianfeng
J
Ma
Ding
D
D000595:Amino Acid Sequence; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000502:physiology; D001483:Base Sequence; D002417:Cattle; D016923:Cell Death / Q000502:physiology; D016000:Cluster Analysis; D003198:Computer Simulation; D030541:Databases, Genetic; D023281:Genomics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D040901:Proteomics; D016415:Sequence Alignment
D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; C484209:TMBIM6 protein, human