title: Effects of radiofrequency catheter ablation on myocardial performance index and plasma NT-Pro-BNP levels in patients with Wolff-Parkinson-White syndrome.
abstract: BACKGROUND
  The myocardial performance index (Tei index) is an echocardiographic index of combined systolic and diastolic functions. Brain natriuretic peptide (BNP) and its biologically inactive fragment N-terminal pro-BNP (NT-pro-BNP) are secreted by the heart in response to myocardial stretch. In this study, we investigated Tei index and NT-pro-BNP levels in patients with Wolff-Parkinson-White (WPW) syndrome before and after radiofrequency catheter ablation therapy (RFCA).
  
  
  METHODS
  Thirty patients (19 males, 11 females, aged 35.5 +/- 14.4 years) with WPW syndrome were enrolled in this study. Echocardiographic examination was performed before and 24 hours after RFCA. Tei index was calculated using Doppler echocardiography. Blood samples were taken before and 24 hours after RFCA to detect levels of NT-pro-BNP.
  
  
  RESULTS
  Although isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) did not change, aortic ejection time (ET) was decreased after RFCA (276 +/- 22 ms vs 254 +/- 30 ms, P < 0.01). So Tei index was significantly higher in postablation period (0.36 +/- 0.11 vs 0.42 +/- 0.21, P < 0.05). NT-pro-BNP levels did not change significantly after RFCA.
  
  
  CONCLUSIONS
  We demonstrated that restoration of normal atrioventricular conduction by RFCA, leads to increase in Tei index but does not effect plasma NT-pro-BNP levels.
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Center, Istanbul, Turkey.
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Cakmak
authors.forename: Nurten
authors.initials: N
authors.lastname: Sayar
authors.forename: Mahmut
authors.initials: M
authors.lastname: Cakmak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akyol
authors.forename: Enis
authors.initials: E
authors.lastname: Oguz
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Eksik
authors.forename: Ahmet Taha
authors.initials: AT
authors.lastname: Alper
authors.forename: Hakan
authors.initials: H
authors.lastname: Hasdemir
authors.forename: Hale
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Izzet
authors.initials: I
authors.lastname: Erdinler
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D015331:Cohort Studies; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011182:Postoperative Care / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011379:Prognosis; D020127:Recovery of Function; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014927:Wolff-Parkinson-White Syndrome / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain