title: An assessment of linezolid utilization in selected canadian provinces.
abstract: BACKGROUND
  Linezolid is approved for the treatment of designated infections caused by methicillin-resistant and -susceptible Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
  
  
  OBJECTIVE
  To characterize linezolid utilization since its launch in Canada in 2001.
  
  
  METHODS
  Demographics, antimicrobial regimens, and clinical and resource utilization data for linezolid-treated patients were collected retrospectively by hospital pharmacists at nine tertiary care hospitals in four provinces. Statistics describing linezolid utilization were calculated and the appropriateness of use was assessed according to a treatment algorithm based on recommendations of the Infectious Diseases Pharmacy Specialty Network in 2001.
  
  
  RESULTS
  Ninety-nine linezolid courses were prescribed for 103 infections in 95 patients (mean age 57.8 years, 52.6% male) with an average length of hospital stay of 40.6 days. Fifty-three per cent of patients had an allergy to at least one antibiotic other than linezolid. The major use of linezolid was for treatment of skin and soft tissue infections (32.0%), followed by bacteremia (15.5%). The most prevalent pathogen was methicillin-resistant S aureus, identified in 44.7% of infections. Linezolid was primarily prescribed as the oral form following other intravenous anti-infectives (55.6% of courses) for an average duration of 14.4 days. The rate of appropriate utilization was 53% (range 25% to 75% by site). In 93.5% of courses deemed inappropriate, recommended first-line therapies were not attempted before linezolid.
  
  
  CONCLUSIONS
  Linezolid was prescribed appropriately in approximately one-half of cases reviewed. The rate of appropriate utilization is similar to those rates reported in other Canadian antibiotic reviews.
authors.affiliation: Department of Pharmacy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Walker
authors.forename: Linda
authors.initials: L
authors.lastname: Dresser
authors.forename: Debbie
authors.initials: D
authors.lastname: Becker
authors.forename: Alissa
authors.initials: A
authors.lastname: Scalera