[Influence of polymorphism's of endothelial nitric oxide synthase gene and polymorphism of NADPH oxidase gene on development of complications of arterial hypertension].
The aim of the study was to analyze the prevalence of polymorphism Glu298Asp of endothelial nitric oxide synthase gene and C242T p22 phox polymorphism of NADPH oxidase gene in patients with arterial hypertension (AH) and their influence on AH complications. The study included 272 AH patients, average age 50,7 years. The following analyses were performed: clinical analysis of the blood, general analysis of the urine, lipid spectrum, plasma electrolytes, creatinine, glucose, electrocardiography, echocardioscopy, examination of eye vessels, ultrasound examination of the carotid arteries, determination of microalbuminuria. The polymorphism Glu298Asp of endothelial nitric oxide synthase gene and C242T p22 phox polymorphism of NADPH oxidase gene were detected with two methods: polymerase chain reaction and restrictase reaction. The control group for Glu298Asp polymorphism detection included 102 healthy Russian donors aged 18 to 50 years. Genotypes prevalence in AH patients was as follows: GG 58,8%, GA 32,3%, AA 8,9%, and CC 48,2%, CT 44,9%, TT 6.9%. In the control group: GG 53%, GA 36%, AA 11% and CC 42%, CT 54%, TT 4%. These polymorphisms did not affect the incidence of complications, such as obliterating atherosclerosis of the lower extremity vessels, ischemic heart disease, and acute insufficiency of cerebral circulation, chronic heart failure, left ventricular hypertrophy, microalbuminuria, carotid arteries atherosclerosis.
Kuznetsova
T Iu
TIu
Medical Facultet Petrgy, pr-t Lenina, Petrozavodsk, Russia.
Gavrilov
D V
DV
Dudanov
I P
IP
Makarevich
P I
PI
Balatskiĭ
A V
AV
Samokhodskaia
L M
LM
Parfenova
E V
EV
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004247:DNA / Q000235:genetics*; D004452:Echocardiography; D004562:Electrocardiography; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000097:blood / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis
D004247:DNA; D052250:Nitric Oxide Synthase Type III; D019255:NADPH Oxidases