title: Serum S100B but not NSE levels are increased in morbidly obese individuals affected by obstructive sleep apnea-hypopnea syndrome.
abstract: BACKGROUND
  Obstructive sleep apnea-hypopnea syndrome (OSAHS) is considered a comorbidity associated with morbid obesity, mainly because of the large neck circumference. Depending on its severity, OSAHS can interfere in many homeostasis systems, for example, the central nervous system (CNS). Neuron-specific enolase (NSE) and S100B protein derived from astrocytes are considered sensitive biochemical markers of cerebral injury. We evaluated serum S100B and NSE levels in this study with the aim of detecting possible cerebral injury as a consequence of OSAHS.
  
  
  METHODS
  This was a transverse study with data from 25 morbidly obese patients with OSAHS. Blood samples were collected before and after polysomnography (PSG) to determine S100B and NSE protein levels. We also analyzed data evaluating depression and excessive daytime sleepiness.
  
  
  RESULTS
  S100B levels were higher after [0.029 (0.010-0.199) mg/l] compared to before [0.010 (0.010-0.025) mg/l] on PSG (P = 0.002). S100B levels were expressed as means and IQ25-IQ75. NSE levels did not show significant differences before and after PSG.
  
  
  CONCLUSIONS
  Our study shows a significant increase in S100B level after PSG compared to before. This suggests that there is a CNS astrocyte reaction because of possible cerebral hypoxemia in morbidly obese patients with OSAHS.
authors.affiliation: Centro da Obesidade Mórbida, Hospital São Lucas da PUCRS, Av. Ipiranga 6690/302, Porto Alegre, RS, Brazil. legiaco@terra.com.br
authors.forename: Leandro Giacometti
authors.initials: LG
authors.lastname: da Silva
authors.forename: Cláudio Corá
authors.initials: CC
authors.lastname: Mottin
authors.forename: Diogo Onofre
authors.initials: DO
authors.lastname: Souza
authors.forename: Luiz Valmor
authors.initials: LV
authors.lastname: Portela
authors.forename: Carla Winei
authors.initials: CW
authors.lastname: Braga
authors.forename: Carolina Boeira
authors.initials: CB
authors.lastname: Vargas
authors.forename: Alexandre Vontobel
authors.initials: AV
authors.lastname: Padoin
authors.forename: Denis
authors.initials: D
authors.lastname: Martinez
authors.forename: Renato Dutra
authors.initials: RD
authors.lastname: Dias
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D017286:Polysomnography; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012890:Sleep / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications*
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase