Are there predictors for failed expectant management of cervical intraepithelial neoplasia 1?
OBJECTIVE
To identify the short-term natural history of cervical intraepithelial neoplasia (CIN) 1 and the potential risk factors for its progression, regression and persistence and to identify any characteristics of patients who were lost to follow-up.


METHODS
All colposcopic specimens from July 2001 through December 2004 were evaluated for the presence of CIN 1. Adequate follow-up was defined as 24 months of surveillance with Pap smears every 4-6 months. The chi2 and Student t test were performed for analysis.


RESULTS
Three hundred sixty women who had colposcopic specimens with the presence of CIN 1 were evaluated. Persistence of CIN 1 and progression to CIN 2 and 3 were associated with pregnancy at the time of colposcopy (p = 0.04), history of sexually transmitted diseases (p = 0.007) and age at first intercourse (p = 0.04). Age (p = 0.001) and no prior history of abnormal Pap smears (p = 0.001) were associated with the rate of loss to follow-up.


CONCLUSIONS
Expectant management for the majority of patients with biopsy-proven CIN 1 is appropriate, but some risk factors might influence that decision. In this study, age at first intercourse was the only independent predictor of failure to resolve CIN 1 on multivariate analysis.
Dunn
Terry S
TS
Department of Obstetrics and Gynecology, Denver Health Medical Center, University of Colorado Health Science Center, Denver, USA. tdunnmd@urogyns.com
Charnsangavej
Chutaporn
C
Wolf
Douglas
D
D000328:Adult; D000367:Age Factors; D003075:Coitus; D003127:Colposcopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015999:Multivariate Analysis; D011247:Pregnancy; D011379:Prognosis; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*