[Influence of staphylococcin T on Enterococcus sp. growth].
Bacteriocins are ribosomally synthesised, extracellular bacterial products. Generally, spectrum of inhibition is limited to the same or closely related species to bacteriocin producer. Staphylococcin T is produced by Staphylococcus cohnii strain. The present study concerns influence of StT to 267 Enterococcus sp. strains growth isolated between 2003 and 2006 in Department of Microbiology University Hospital of dr. A. Jurasz in Bydgoszcz. S. cohnii T antagonistic ability evaluated towards bacteries on Mueller-Hinton Agar (bio Mérieux) in aerobic conditions. After 24 and 48 hours tested enterococci suspensions were plated perpendiculary. Susceptibility to antibiotics was assessed by disc diffusion method according to the guideless of Clinical and Laboratory Standards Institute and National Reference Centre for Antimicrobial Susceptibility. Among Enterococcus sp. strains tested 7.1% were sensitive to StT. The highest percentage of sensitive enterococci isolated from wound swabs, urine, blood and pus. Enterococcus faecium strains dominated (63.2%) among enterococci sensitive to StT. Moderate inhibition degree on S. cohnii T bacteriocin action was observed in majority sensitive enterococci strains. Enterococcus sp. sensitive to StT strains were frequently multidrug resistant (68.4%). According to the study results and increasing resistance to antibiotics, StT could be an alternative agent used to treat infections caused by Enterococcus sp.
Białucha
Agata
A
Katedra i Zakład Mikrobiologii Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytetu Mikołaja Kopemika w Toruniu.
Kozuszko
Sylwia
S
Gospodarek
Eugenia
E
Bugalski
Roman Marian
RM
Gierlotka
Krzysztof
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D016983:Enterococcus / Q000187:drug effects* / Q000254:growth & development* / Q000302:isolation & purification; D016984:Enterococcus faecium / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010455:Peptides; C057656:gallidermin