Semaphorin signaling in morphogenesis: found in translation.
Semaphorins play diverse roles in axon guidance and epithelial morphogenetic cell movements. In this issue of Genes & Development, Nukazuka and colleagues (1025-1036) show that semaphorins regulate Caenorhabditis elegans male tail morphogenesis by stimulating the translation of specific messages, including the actin-depolymerizing enzyme cofilin.
Chisholm
Andrew D
AD
Division of Biological Sciences, Section of Neurobiology, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093, USA. chisholm@ucsd.edu
D051339:Actin Depolymerizing Factors / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics*; D014176:Protein Biosynthesis; D039961:Semaphorins / Q000378:metabolism*; D015398:Signal Transduction; D013623:Tail / Q000502:physiology
D051339:Actin Depolymerizing Factors; D039961:Semaphorins