title: Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma.
abstract: OBJECTIVE
  To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC).
  
  
  METHODS
  A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage II and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT.
  
  
  RESULTS
  The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, alpha-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m > or = 20% than in those with TRR1m < 20% (P < 0.001).
  
  
  CONCLUSIONS
  RT is effective in treating advanced HCC with a tumor response rate of 56.9%.
authors.affiliation: Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Sungbuk-gu, Seoul 136-705, Korea. umsh@korea.ac.kr.
authors.forename: Yeon Seok
authors.initials: YS
authors.lastname: Seo
authors.forename: Jin Nam
authors.initials: JN
authors.lastname: Kim
authors.forename: Bora
authors.initials: B
authors.lastname: Keum
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Park
authors.forename: Yong Dae
authors.initials: YD
authors.lastname: Kwon
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Yoon Tae
authors.initials: YT
authors.lastname: Jeen
authors.forename: Hoon Jai
authors.initials: HJ
authors.lastname: Chun
authors.forename: Chul Yong
authors.initials: CY
authors.lastname: Kim
authors.forename: Chang Duck
authors.initials: CD
authors.lastname: Kim
authors.forename: Ho Sang
authors.initials: HS
authors.lastname: Ryu
authors.forename: Soon Ho
authors.initials: SH
authors.lastname: Um
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011878:Radiotherapy / Q000009:adverse effects; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: C097353:AFP protein, human; D000509:alpha-Fetoproteins