Acute effects of 1-octyl-3-methylimidazolium bromide ionic liquid on the antioxidant enzyme system of mouse liver.
The effects of acute exposure of intraperitoneal injection of aqueous 1-octyl-3-methylimidazolium bromide on the antioxidant enzymes and lipid peroxidation of the treated mouse liver were investigated in the present paper. Thirty mice were treated with 17.9 (0.5 median lethal dose, LD(50)) and 35.7 mg/kg (1 LD(50)) of the ionic liquid or saline solution by intraperitoneal injection for 10h. Significant increase in hepatosomatic index and decrease in liver protein content were found in 1 LD(50) group. No statistically significant change was observed in the activity of superoxide dismutase in both treated groups compared to the control group. In the case of catalase activity, the decrease was recorded only at dose of 1 LD(50). As for the activity of glutathione peroxidase, increase in 0.5 LD(50) group while significant decrease at dose of 1 LD(50) was noted. There was an increase in the activity of glutathione-S-transferase in these two treated groups in comparison to the control. However, no effect on the level of lipid peroxidation was found in the treated groups. These results showed that the acute exposure of aqueous ionic liquid could cause damage to mouse, leading to antioxidant responses in livers of the treated mice.
Yu
Miao
M
School of Life Science, Henan Normal University, Xinxiang 453007, China.
Li
Su-Mei
SM
Li
Xiao-Yu
XY
Zhang
Bang-Jun
BJ
Wang
Jian-Ji
JJ
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007093:Imidazoles / Q000633:toxicity*; D052578:Ionic Liquids / Q000633:toxicity*; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
C534649:1-methyl-3-octylimidazolium bromide; D000975:Antioxidants; D007093:Imidazoles; D052578:Ionic Liquids; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase