Emerging non-invasive Raman methods in process control and forensic applications.
This article reviews emerging Raman techniques (Spatially Offset and Transmission Raman Spectroscopy) for non-invasive, sub-surface probing in process control and forensic applications. New capabilities offered by these methods are discussed and several application examples are given including the non-invasive detection of counterfeit drugs through blister packs and opaque plastic bottles and the rapid quantitative analysis of the bulk content of pharmaceutical tablets and capsules without sub-sampling.
Macleod
Neil A
NA
Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, UK.
Matousek
Pavel
P
D002214:Capsules; D004340:Drug Contamination / Q000517:prevention & control; D044707:Forensic Sciences / Q000592:standards / Q000639:trends*; D005607:Fraud / Q000517:prevention & control; D011786:Quality Control; D012815:Signal Processing, Computer-Assisted; D013059:Spectrum Analysis, Raman / Q000592:standards; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000592:standards / Q000639:trends*
D002214:Capsules; D013607:Tablets