title: 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers.
abstract: Accurate measurement of flow in microfluidic systems is both challenging and important, providing information that can be used to better understand flow fields within laboratory-on-a-chip devices and validate computational simulations. Here, we use optical tweezers within a microfluidic system to measure the velocity vectors of flow fields in two and three dimensions around a microstructures including both molded features within channels and cells. The experimental results are compared to a complex fluid dynamics model showing an agreement between the two of better than 3 microm/s. This measurement is highly reproducible and minimally invasive, which in the future could be used to provided more in-depth studies of the rheological properties of biological cells and microstructures in laboratory-on-a-chip devices.
authors.affiliation: Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, UK.
authors.forename: Hasan
authors.initials: H
authors.lastname: Mushfique
authors.forename: Jonathan
authors.initials: J
authors.lastname: Leach
authors.forename: Huabing
authors.initials: H
authors.lastname: Yin
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Leonardo
authors.forename: Miles J
authors.initials: MJ
authors.lastname: Padgett
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Cooper