Studying posttranslational modifications by in-cell NMR.
Functional in vivo investigation of posttranslational modifications is a problem that a number of analytical techniques are trying to tackle. Below, we briefly discuss the breakthroughs and challenges in placing NMR spectroscopy on the map, as illustrated by a recent report by Selenko et al. (2008).
Lippens
G
G
CNRS-USTL UMR 8576, Structural and Functional Glycobiology, University of Lille I, 59655 Villeneuve d'Ascq, France. Guy.Lippens@univ-lille1.fr
Landrieu
I
I
Hanoulle
X
X
D047390:Casein Kinase II / Q000378:metabolism; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D016875:tau Proteins / Q000378:metabolism
D016875:tau Proteins; D047390:Casein Kinase II