title: Magnetic resonance direct thrombus imaging of the evolution of acute deep vein thrombosis of the leg.
abstract: BACKGROUND
  Accurate diagnosis of acute recurrent deep vein thrombosis (DVT) is relevant to avoid improper diagnosis and unnecessary life-long anticoagulant treatment. Compression ultrasound has high accuracy for a first episode of DVT, but is often unreliable in suspected recurrent disease. Magnetic resonance direct thrombus imaging (MR DTI) has been shown to accurately detect acute DVT. The purpose of this prospective study was to determine the MR signal change during 6 months follow-up in patients with acute DVT.
  
  
  METHODS
  This study was a prospective study of 43 consecutive patients with a first episode of acute DVT demonstrated by compression ultrasound. All patients underwent MR DTI. Follow-up was performed with MR-DTI and compression ultrasound at 3 and 6 months respectively. All data were coded, stored and assessed by two blinded observers.
  
  
  RESULTS
  MR direct thrombus imaging identified acute DVT in 41 of 43 patients (sensitivity 95%). There was no abnormal MR-signal in controls, or in the contralateral extremity of patients with DVT (specificity 100%). In none of the 39 patients available at 6 months follow-up was the abnormal MR-signal at the initial acute DVT observed, whereas in 12 of these patients (30.8%) compression ultrasound was still abnormal.
  
  
  CONCLUSIONS
  Magnetic resonance direct thrombus imaging normalizes over a period of 6 months in all patients with diagnosed DVT, while compression ultrasound remains abnormal in a third of these patients. MR-DTI may potentially allow for accurate detection in patients with acute suspected recurrent DVT, and this should be studied prospectively.
authors.affiliation: Department of Radiology, Haga Teaching Hospital-Leyenburg, The Hague, The Netherlands.
authors.forename: R E
authors.initials: RE
authors.lastname: Westerbeek
authors.forename: C J
authors.initials: CJ
authors.lastname: Van Rooden
authors.forename: M
authors.initials: M
authors.lastname: Tan
authors.forename: A P G
authors.initials: AP
authors.lastname: Van Gils
authors.forename: S
authors.initials: S
authors.lastname: Kok
authors.forename: M J
authors.initials: MJ
authors.lastname: De Bats
authors.forename: A
authors.initials: A
authors.lastname: De Roos
authors.forename: M V
authors.initials: MV
authors.lastname: Huisman
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D014465:Ultrasonics; D020246:Venous Thrombosis / Q000473:pathology*