Quantitative comparison of a corona-charged aerosol detector and an evaporative light-scattering detector for the analysis of a synthetic polymer by supercritical fluid chromatography.
A corona-charged aerosol detector (CAD) was developed to improve the sensitivity, reproducibility and quantitativeness of detection as compared to evaporative light-scattering detector (ELSD) for liquid chromatography. Our laboratory used the corona CAD as a detector for supercritical fluid chromatography (SFC) and evaluated its performance compared to the ELSD by using a certified reference material of poly(ethylene glycol) (PEG) and a well-defined equimass mixture of uniform PEG oligomers. The corona CAD was able to detect a 10 times more dilute solution of uniform oligomers compared to the ELSD. Although the original data of molecular mass by ELSD was 4.6% smaller than the certified value of PEG 1000, molecular mass distribution obtained by corona CAD was virtually almost the same as the certified value without any calibrations.
Takahashi
Kayori
K
National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan. kayori.takahashi@ni.aist.go.jp
Kinugasa
Shinichi
S
Senda
Masaaki
M
Kimizuka
Koki
K
Fukushima
Kyoko
K
Matsumoto
Tsutomu
T
Shibata
Yasuhiro
Y
Christensen
John
J
D000336:Aerosols / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D008027:Light; D011108:Polymers / Q000032:analysis*; D012542:Scattering, Radiation
D000336:Aerosols; D011108:Polymers