title: Molecularly imprinted poly (methacrylamide-co-methacrylic acid) composite membranes for recognition of curcumin.
abstract: In this study, molecularly imprinted poly (methacrylamide-co-methacrylic acid) composite membranes with different ratio of methacrylamide (MAM) versus methacrylic acid (MAA) were prepared via UV initiated photo-copolymerization on the commercial filter paper. Curcumin was chosen as the template molecule. Infra-red (IR) spectroscopy was used to study the binding mechanism between the imprinted sites and the templates. The morphology of the resultant membranes was visualized by scanning electron microscopy (SEM). Static equilibrium binding and recognition properties of the imprinted composite membranes to curcumin (cur-I) and its analogues demethoxycurcumin (cur-II) or bisdemethoxycurcumin (cur-III) were tested. The results showed that curcumin-imprinted membranes had the best recognition ability to curcumin compared to its analogues. From the results, the biggest selectivity factor of alpha(cur-I/cur-II) and alpha(cur-I/cur-III) were 1.50 and 5.94, and they were obtained from the composite membranes in which MAM/MAA were 1:4 and 0:1, respectively. The results of this study implied that the molecularly imprinted composite membranes could be used as separation membranes for curcumin enrichment.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University of Technology, Zhejiang Key Laboratory of Pharmaceutical Engineering, Hangzhou 310014, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Wenming
authors.initials: W
authors.lastname: Hu
authors.forename: Weike
authors.initials: W
authors.lastname: Su
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000528:radiation effects; D003474:Curcumin / Q000031:analogs & derivatives / Q000032:analysis*; D036381:Diarylheptanoids; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry / Q000528:radiation effects; D008855:Microscopy, Electron, Scanning / Q000379:methods; D054802:Molecular Imprinting; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D000178:Acrylamides; D036381:Diarylheptanoids; D008567:Membranes, Artificial; D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; C529874:poly(methacrylamide-co-methacrylic acid); C008384:methacrylic acid; C034786:bisdemethoxycurcumin; D003474:Curcumin; C045985:methacrylamide; C050229:demethoxycurcumin