Expression of interleukin-10 in patients with adenomyosis.
OBJECTIVE
To investigate the expression of interleukin-10 (IL-10) in adenomyosis.


METHODS
Laboratory study using human tissue.


METHODS
University hospital.


METHODS
Thirty-four patients with adenomyosis and 30 women without adenomyosis who underwent hysterectomy for nonendometrial pathology.


METHODS
Tissue sections were immunostained with murine monoclonal antihuman IL-10 antibodies.


METHODS
Microscopic evaluation to assess the presence and localization of IL-10 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with IL-10 expression in the normal endometrium.


RESULTS
In the eutopic and ectopic endometrium of women with adenomyosis, epithelial cells showed higher staining intensity than the normal controls. However, no significant differences were found in the epithelial IL-10 immunostaining H score values between the eutopic endometrium and adenomyosis foci. Nonetheless, we observed a cyclic variation in the eutopic epithelial IL-10 immunoreactivity throughout the menstrual cycle with higher H score values in the secretory phase than in the proliferative phase.


CONCLUSIONS
These findings suggest that an abnormality of inflammatory response may be present in the eutopic and ectopic endometrium of women with adenomyosis and that IL-10 may contribute to the pathogenesis and pathophysiology of adenomyosis.
Wang
Fei
F
Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
Li
Hui
H
Yang
Zhongli
Z
Du
Xuelian
X
Cui
Min
M
Wen
Zeqing
Z
D000328:Adult; D004715:Endometriosis / Q000276:immunology*; D004717:Endometrium / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000032:analysis*; D008875:Middle Aged; D014591:Uterine Diseases / Q000276:immunology*
D016753:Interleukin-10