Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis.
OBJECTIVE
To investigate the feasibility of laparoscopic high-intensity focused ultrasound (HIFU) ablation in the treatment of patients with uterine localized adenomyosis.


METHODS
A prospective clinical trial.


METHODS
University teaching hospital.


METHODS
Seven patients with uterine localized adenomyosis.


METHODS
Using a hand-held focused ultrasound transducer, the HIFU procedure was performed by the same gynecologist for the treatment of a targeted adenomyosis during the surgical procedure, followed by hysterectomy.


METHODS
Feasibility and effectiveness of HIFU treatment of localized adenomyomas.


RESULTS
Macroscopic and microscopic examinations showed that HIFU induced thermal ablation of a targeted adenomyosis in all patients. The treated adenomyosis presented typical characteristics of coagulation necrosis, and the margin between the treated and untreated regions was clear in 2,3,5-triphenyltetrazolium chloride staining. By using electronic microscopy and nicotinamide adenine dinucleotide-diaphorase stain, complete loss of cellular viability was identified in the treated tissue.


CONCLUSIONS
The HIFU treatment is feasible and effective in the treatment of patients with uterine localized adenomyosis. It may provide a promising laparoscopic treatment for localized adenomyosis.
Yang
Zhu
Z
Department of Obstetrics & Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China. cqyangz@vip.163.com
Cao
You-De
YD
Hu
Li-Na
LN
Wang
Zhi-Biao
ZB
D016923:Cell Death; D004715:Endometriosis / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D009336:Necrosis; D011446:Prospective Studies; D014464:Ultrasonic Therapy / Q000379:methods*; D014591:Uterine Diseases / Q000473:pathology* / Q000628:therapy*; D014599:Uterus / Q000473:pathology / Q000648:ultrastructure