title: Novel fluorescent core-shell nanocontainers for cell membrane transport.
abstract: The synthesis and characterization of novel core-shell macromolecules consisting of a fluorescent perylene-3,4,9,10-tetracarboxdiimide chromophore in the center surrounded by a hydrophobic polyphenylene shell as a first and a flexible hydrophilic polymer shell as a second layer was presented. Following this strategy, several macromolecules bearing varying polymer chain lengths, different polymer shell densities, and increasing numbers of positive and negative charges were achieved. Because all of these macromolecules reveal a good water solubility, their ability to cross cellular membranes was investigated. In this way, a qualitative relationship between the molecular architecture of these macromolecules and the biological response was established.
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Meizhen
authors.initials: M
authors.lastname: Yin
authors.forename: Christoph R W
authors.initials: CR
authors.lastname: Kuhlmann
authors.forename: Ksenia
authors.initials: K
authors.lastname: Sorokina
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: George
authors.initials: G
authors.lastname: Mihov
authors.forename: Eweline
authors.initials: E
authors.lastname: Pietrowski
authors.forename: Kaloian
authors.initials: K
authors.lastname: Koynov
authors.forename: Markus
authors.initials: M
authors.lastname: Klapper
authors.forename: Heiko J
authors.initials: HJ
authors.lastname: Luhmann
authors.forename: Klaus
authors.initials: K
authors.lastname: Müllen
authors.forename: Tanja
authors.initials: T
authors.lastname: Weil
mesh_terms: D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004337:Drug Carriers / Q000493:pharmacokinetics*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D011108:Polymers; C041325:polyphenylene sulfide