title: A polar radical pair pathway to assemble the pyrimidinone core of the HIV integrase inhibitor raltegravir potassium.
authors.affiliation: Department of Process Research, Merck Research Laboratories, Rahway, NJ 07065, USA. philip_pye@merck.com
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Pye
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Zhong
authors.forename: Gavin O
authors.initials: GO
authors.lastname: Jones
authors.forename: Robert A
authors.initials: RA
authors.lastname: Reamer
authors.forename: Kendall N
authors.initials: KN
authors.lastname: Houk
authors.forename: David
authors.initials: D
authors.lastname: Askin
mesh_terms: D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium
chemical_list: D019428:HIV Integrase Inhibitors; D009930:Organic Chemicals; D011744:Pyrimidinones; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D011188:Potassium