title: Synthesis of beta-L-2'-deoxythymidine (L-dT).
abstract: The "unnatural" l-nucleoside beta-l-2'-deoxythymidine (L-dT) is a potent, specific, and selective inhibitor of the replication of hepatitis B virus (HBV), which is currently in Phase III clinical trials. This unit describes, in detail, a semi-large-scale synthesis of l-dT. This convenient methodology produces l-dT in six steps starting with l-ribose and ending with a satisfactory overall yield of l-dT, and may be applied to other 2'-deoxynucleosides, incorporating different heterocyclic bases.
authors.affiliation: Université Montpellier II, Montpellier, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Pierra
authors.forename: David
authors.initials: D
authors.lastname: Dukhan
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Sommadossi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology; D013936:Thymidine / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D013936:Thymidine