title: Antiproliferative oleanane saponins from Meryta denhamii.
abstract: Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Universitaàdi Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Cioffi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Dal Piaz
authors.forename: Antonio
authors.initials: A
authors.lastname: Vassallo
authors.forename: Fabio
authors.initials: F
authors.lastname: Venturella
authors.forename: Paolo
authors.initials: P
authors.lastname: De Caprariis
authors.forename: Francesco
authors.initials: F
authors.lastname: De Simone
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027481:Araliaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007558:Italy; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C413246:oleanane; D009828:Oleanolic Acid