Primate model of uveoretinitis and vasculitis/experimental autoimmune uveoretinitis induced in cynomolgus monkeys by retinal s antigen.
OBJECTIVE
We aimed to describe the clinical and angiographic changes in an experimental model of autoimmune uveoretinitis and vasculitis in primates.


METHODS
Six cynomolgus monkeys received a single subcutaneous immunization with 100 microg of human S antigen with complete Freund's adjuvant.


RESULTS
All the animals had a bilateral long-term disease occurring usually in 1 eye approximately 4 weeks after immunization, the second eye being involved 1-5 weeks later. A cyclic course of the disease could be demonstrated by repeated fundus fluorescein angiograms. The initial and principal manifestation consisted in retinal vascular sheathing affecting veins and venules. The more severe forms showed areas of posterior uveoretinitis, dense vitritis and anterior uveitis.


CONCLUSIONS
A single systemic injection of pure human retinal S antigen could induce a chronic and recurrent ocular disease similar to human retinal vasculitis.
LeHoang
Phuc
P
Department of Ophthalmology, University Pierre et Marie Curie, Pitié-Salpêtrière Medical School, Assistance Publique, Hôpitaux de Paris, Paris, France. phuc.lehoang@psl.aphp.fr
Sterkers
Margaret
M
Thillaye
Brigitte
B
de Kozak
Yvonne
Y
Coscas
Gabriel
G
Faure
Jean Pierre
JP
D000276:Adjuvants, Immunologic; D000818:Animals; D019393:Arrestin; D004195:Disease Models, Animal; D018450:Disease Progression; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005620:Freund's Adjuvant; D005654:Fundus Oculi; D007114:Immunization / Q000009:adverse effects; D017075:Laser Coagulation; D008252:Macaca fascicularis; D033401:Microscopy, Acoustic; D012008:Recurrence; D012160:Retina / Q000000981:diagnostic imaging / Q000473:pathology*; D031300:Retinal Vasculitis / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D012169:Retinal Vein / Q000473:pathology*; D012173:Retinitis / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D012720:Severity of Illness Index; D014605:Uveitis / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D014822:Vitreous Body / Q000000981:diagnostic imaging / Q000473:pathology*
D000276:Adjuvants, Immunologic; D019393:Arrestin; D005620:Freund's Adjuvant