title: Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage.
abstract: AIB1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of NPC and 20 specimens of nonneoplastic nasopharyngeal mucosa. In this NPC cohort, overexpression and amplification of AIB1 was detected in 36 (51%) of 71 and 3 (7%) of 46 NPCs, respectively. Overexpression of AIB1 was observed more frequently in NPCs in late T stages (T3/T4, 24/35 [69%]) than in earlier stages (T1/T2, 12/36 [33%]; P < .05). In addition, 18 (72%) of 25 NPCs with lymph node metastasis (N1-3) showed overexpression of AIB1; the frequency was significantly higher than that in NPCs without node metastasis (N0, 18/49 [39%]; P < .05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Meng-Zhong
authors.initials: MZ
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Shi-Juan
authors.initials: SJ
authors.lastname: Mai
authors.forename: Zhu-Ting
authors.initials: ZT
authors.lastname: Tong
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Shao
authors.forename: Yong-Shui
authors.initials: YS
authors.lastname: Fu
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Xia
authors.forename: Hsian-Fu
authors.initials: HF
authors.lastname: Kung
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Guan
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D051548:Histone Acetyltransferases / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D019394:Ki-67 Antigen / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D056921:Nuclear Receptor Coactivator 3; D046888:Tissue Array Analysis; D015534:Trans-Activators / Q000096:biosynthesis*
chemical_list: D019394:Ki-67 Antigen; D015534:Trans-Activators; D051548:Histone Acetyltransferases; C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3