title: Animal models of intraocular lymphomas.
abstract: Primary intraocular lymphoma is a high-grade non-Hodgkin lymphoma whose pathogenesis is still unclear. Few animal models exist in order to study this condition. Although intraocular lymphomas in humans are usually B cell lymphomas, most of these models are T cell lymphomas. Recently, a major step forward has been realized with the development of new models of intraocular B cell lymphoma. New therapeutic tools are being evaluated in these models of B cell lymphoma. We evaluate the contribution of the different animal models available to study intraocular lymphomas, and we discuss the new therapeutic strategies and their various targets in the tumor as well as in the environment, which are currently investigated through the development of these models.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Centre de Recherche des Cordeliers, Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Touitou
authors.forename: Bahram
authors.initials: B
authors.lastname: Bodaghi
authors.forename: Yvonne
authors.initials: Y
authors.lastname: de Kozak
authors.forename: Phuc
authors.initials: P
authors.lastname: Lehoang
authors.forename: Catherine
authors.initials: C
authors.lastname: Sautès-Fridman
authors.forename: Sylvain
authors.initials: S
authors.lastname: Fisson
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D005134:Eye Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009374:Neoplasms, Experimental
chemical_list: D016207:Cytokines