The outcome of pregnancy following topiramate treatment: a study on 52 pregnancies.
In spite of a substantial increase in the use of topiramate at child bearing age, very little is known regarding its use in pregnancy. We describe the outcome of 52 pregnancies with 41 liveborn infants from which it seems that topiramate reduces birth weight without decreasing gestational age at delivery, but does not seem to increase the risk for structural defects. There was an increased rate of spontaneous abortions not related to the drug effects.
Ornoy
Asher
A
The Israeli Teratogen Information Service, Laboratory of Teratology, Hebrew University, Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel. ornoy@cc.huji.ac.il
Zvi
Naama
N
Arnon
Judy
J
Wajnberg
Rebecka
R
Shechtman
Svetlana
S
Diav-Citrin
Orna
O
D000014:Abnormalities, Drug-Induced; D000022:Abortion, Spontaneous / Q000139:chemically induced*; D000927:Anticonvulsants / Q000633:toxicity*; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000633:toxicity; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose