title: Rapid differentiation of methicillin-susceptible Staphylococcus aureus from methicillin-resistant S. aureus and MIC determinations by isothermal microcalorimetry.
abstract: In this study, the use of isothermal microcalorimetry (IMC) for differentiation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) and MIC determination was evaluated. It was possible to differentiate between MRSA and MSSA within 4 h, whereas the standard method required 24 h. The MICs of cefoxitin were successfully determined for MRSA and MSSA by using IMC.
authors.affiliation: Laboratory for Orthopaedic Biomechanics, Clinical Morphology & Biomedical Engineering, University of Basel Faculty of Medicine, Basel, Switzerland.
authors.forename: Ueli
authors.initials: U
authors.lastname: von Ah
authors.forename: Dieter
authors.initials: D
authors.lastname: Wirz
authors.forename: A U
authors.initials: AU
authors.lastname: Daniels
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002151:Calorimetry / Q000295:instrumentation / Q000379:methods*; D002440:Cefoxitin / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D008712:Methicillin / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D002440:Cefoxitin; D008712:Methicillin