Invasive pulmonary infection due to Trichoderma longibrachiatum mimicking invasive Aspergillosis in a neutropenic patient successfully treated with voriconazole combined with caspofungin.
Trichoderma longibrachiatum, a filamentous fungus, was recently described as an emerging pathogen in immunocompromised patients. Here, we report the first case, to our knowledge, of isolated invasive lung infection by T. longibrachiatum in a patient with hematologic malignancy. The infection mimicked invasive pulmonary aspergillosis and was successfully treated with a combination of voriconazole and caspofungin.
Alanio
Alexandre
A
Department of Parasitology-Mycology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, France.
Brethon
Benoît
B
Feuilhade de Chauvin
Martine
M
de Kerviler
Eric
E
Leblanc
Thierry
T
Lacroix
Claire
C
Baruchel
André
A
Menotti
Jean
J
D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077336:Caspofungin; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000627:therapeutic use*; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D055666:Lipopeptides; D008297:Male; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications*; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use*; D014242:Trichoderma / Q000302:isolation & purification*; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole