title: Gender identity of children and young adults with 5alpha-reductase deficiency.
abstract: Male pseudohermaphroditism (46,XY DSD) due to 5alpha-reductase deficiency has been recognized for the last few decades. There is scant literature on this entity in India. We compiled data on five patients with this disorder. Four of our five patients were reared as females. Our assessment of these children reveals that they had male gender identity from childhood. Three of the four reared as females chose to change gender role at adolescence, while the fourth is still prepubertal. We conclude that all these patients had male gender identity from early childhood. The parents took note of this only after the appearance of male secondary sexual characteristics at puberty, thereby giving an impression of change in gender identity and gender role.
authors.affiliation: Department ofEndocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: E P
authors.initials: EP
authors.lastname: Praveen
authors.forename: Ankush K
authors.initials: AK
authors.lastname: Desai
authors.forename: M L
authors.initials: ML
authors.lastname: Khurana
authors.forename: Jim
authors.initials: J
authors.lastname: Philip
authors.forename: Marumudi
authors.initials: M
authors.lastname: Eunice
authors.forename: Rajesh
authors.initials: R
authors.lastname: Khadgawat
authors.forename: Bindu
authors.initials: B
authors.lastname: Kulshreshtha
authors.forename: Kiran
authors.initials: K
authors.lastname: Kucheria
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Gupta
authors.forename: Ashu
authors.initials: A
authors.lastname: Seith
authors.forename: Ariachery C
authors.initials: AC
authors.lastname: Ammini
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000172:deficiency*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D012734:Disorders of Sex Development / Q000201:enzymology* / Q000523:psychology*; D005260:Female; D005783:Gender Identity; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007194:India; D008297:Male
chemical_list: D006728:Hormones; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase