What is there left to learn about the Drosophila clock?
Circadian rhythms offer probably the best understanding of how genes control behavior, and much of this understanding has come from studies in Drosophila. More recently, genetic manipulation of clock neurons in Drosophila has helped identify how daily patterns of activity are programmed by different clock neuron groups. Here, we review some of the more recent findings on the fly molecular clock and ask what more the fly model can offer to circadian biologists.
Blau
J
J
Department of Biology, New York University, New York, New York 10003, USA.
Blanchard
F
F
Collins
B
B
Dahdal
D
D
Knowles
A
A
Mizrak
D
D
Ruben
M
M
D056930:ARNTL Transcription Factors; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000502:physiology; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics / Q000502:physiology; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D025461:Feedback, Physiological; D017344:Genes, Insect; D008954:Models, Biological; D008959:Models, Neurological; D009154:Mutation; D009446:Neurobiology; D009474:Neurons / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology; D012323:RNA Processing, Post-Transcriptional; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D056930:ARNTL Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D050976:Basic-Leucine Zipper Transcription Factors; D056926:CLOCK Proteins; D029721:Drosophila Proteins; D009479:Neuropeptides; D014157:Transcription Factors; C120526:Clk protein, Drosophila; C109768:PDP1 protein, Drosophila; C112805:cyc protein, Drosophila