title: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
abstract: Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase activity, dramatically increases the motility of infected macrophages and the expression of vascular endothelial growth factor. The transcription factor CREB and the syndecan-1 gene, a CREB target, play crucial roles in ET-induced macrophage migration. These molecular and cellular responses occur in macrophages engaged in antiinflammatory G protein-coupled receptor activation, thus illustrating a common signaling circuitry controlling resolution of inflammation and host cell hijacking by B. anthracis.
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Kim
authors.forename: Sarah
authors.initials: S
authors.lastname: Wilcox-Adelman
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Sano
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Tang
authors.forename: R John
authors.initials: RJ
authors.lastname: Collier
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Park
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000881:Anthrax / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D000942:Antigens, Bacterial / Q000378:metabolism; D001408:Bacillus anthracis / Q000201:enzymology*; D001427:Bacterial Toxins / Q000378:metabolism; D002465:Cell Movement / Q000235:genetics*; D000242:Cyclic AMP / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D018345:Mice, Knockout; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D015398:Signal Transduction; D053668:Syndecan-1 / Q000235:genetics; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C492004:Creb1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D043562:Receptors, G-Protein-Coupled; C508242:Sdc1 protein, mouse; D053668:Syndecan-1; D042461:Vascular Endothelial Growth Factor A; C030325:anthrax toxin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases