title: Pentoxifylline for diabetic retinopathy.
abstract: BACKGROUND
  There is increasing evidence that capillary occlusion plays an important part in the development of diabetic retinopathy. Disaggregants, such as pentoxyfilline may influence the outcome and progression of diabetic retinopathy, but no systematic review of the literature on its efficacy and safety has been published to examine this hypothesis.
  
  
  OBJECTIVE
  The aim of the current research was to review the literature in a systematic way in order to assess the effects of pentoxyfilline for diabetic retinopathy in methodologically robust trials. The null hypothesis was that pentoxyfilline has no influence on the progression of diabetic retinopathy or blindness.
  
  
  METHODS
  A systematic search of electronic databases was carried out to identify publications. Relevant papers, written in any language, were accessed and assessed for data.
  
  
  METHODS
  Only randomized controlled clinical trials (RCTs) evaluating the effects of pentoxyfilline in the treatment of diabetic retinopathy were to be included.
  
  
  METHODS
  Two authors independently assessed studies for inclusion criteria and for risk of bias.
  
  
  RESULTS
  A total of 97 publications were identified by the electronic search and two authors checked the abstracts. Of these, 17 were identified as potentially relevant trials providing information about treatment of patients with diabetic retinopathy using pentoxyfilline and were read in full. Unfortunately, no publication fulfilled our inclusion criteria.
  
  
  CONCLUSIONS
  No sound research to date has examined the treatment of diabetic retinopathy with pentoxyfilline in such a way as to indicate whether this form of intervention has a significant impact on the natural history of this clinical condition. The potential role of this substance in the treatment of diabetic retinopathy remains open to debate, and it is suggested that future research focusing on patient-relevant outcomes takes the opportunity of addressing this important issue directly.
authors.affiliation: Brazilian Cochrane Center, Escola Paulista de Medicina (EPM) - Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 598, São Paulo, Brazil, 04039-001. caceloje@gmail.com
authors.forename: C C
authors.initials: CC
authors.lastname: Lopes de Jesus
authors.forename: A N
authors.initials: AN
authors.lastname: Atallah
authors.forename: O
authors.initials: O
authors.lastname: Valente
authors.forename: V F
authors.initials: VF
authors.lastname: Moça Trevisani
mesh_terms: D003930:Diabetic Retinopathy / Q000188:drug therapy*; D006801:Humans; D010431:Pentoxifylline / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D010431:Pentoxifylline