title: Indeterminate or suspicious breast lesions detected initially with MR imaging: value of MRI-directed breast ultrasound.
abstract: OBJECTIVE
  To retrospectively determine the value of magnetic resonance imaging (MRI)-directed breast ultrasonography (US) in the evaluation of indeterminate or suspicious lesions identified on contrast-enhanced, breast MRI.
  
  
  METHODS
  A total of 395 patients presenting for breast MRI during a 4-year period was retrospectively reviewed. Seventy-one patients were recommended for MRI-directed US for further characterization of indeterminate or suspicious breast lesions detected on MRI. Fifty-five patients (all female; age 31-80 years) had US. Their MRI and US were reviewed and tested for correlations with histologic results or long term follow-up. Logistic regression analyses were used to test for associations between MRI lesion characteristics and US detection rate.
  
  
  RESULTS
  US identified 46 of 97 (47%) lesions depicted at MRI from 55 patients (47 [85%] of these patients had histories of breast malignancies). Twelve cancers were found from the 97 lesions (12%). Biopsy was avoidable in 10 lesions (10%). The detection rate with US was slightly higher with "mass" (55% [23/42]) lesions described in MRI than "non-mass" lesions or lymph nodes (42% [23/55]). There was a significant positive association (odd ratio = 1.23: 95% CI = 1.05-1.43, P = .01) between US detection rate and MRI mass lesion size. There was no statistical significance between US detection rate and the presence of malignancies; 42% (5/12) of MRI malignant lesions were not visualized with US.
  
  
  CONCLUSIONS
  MRI-directed US reduced the number of biopsies required for indeterminate or suspicious MRI lesions. Nevertheless, the lesions which were biopsied had a low rate of malignancy.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Cholatip
authors.initials: C
authors.lastname: Wiratkapun
authors.forename: Deirdre
authors.initials: D
authors.lastname: Duke
authors.forename: Amy S
authors.initials: AS
authors.lastname: Nordmann
authors.forename: Panuwat
authors.initials: P
authors.lastname: Lertsithichai
authors.forename: Vamsidhar
authors.initials: V
authors.lastname: Narra
authors.forename: Premsri T
authors.initials: PT
authors.lastname: Barton
authors.forename: Charles F
authors.initials: CF
authors.lastname: Hildebolt
authors.forename: Kyongtae T
authors.initials: KT
authors.lastname: Bae
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional; D008875:Middle Aged; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA