title: Association between fatty acid binding protein 3 gene variants and essential hypertension in humans.
abstract: BACKGROUND
  We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans.
  
  
  METHODS
  We evaluated two single-nucleotide polymorphisms (SNPs) (rs2279885 and rs2271072) in 758 patients with EH and 726 controls. Polymorphism-related genotypes were determined using TaqMan assays, while haplotypes were estimated from the genotype data.
  
  
  RESULTS
  The frequencies of occurrence of the G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects (P = 0.0339, P = 0.0209, respectively). However, the genotype distributions did not exhibit any significant differences.
  
  
  CONCLUSIONS
  We found an association between FABP3 gene polymorphisms and EH in a Japanese population, thereby suggesting that FABP3 is a susceptibility locus for EH.
authors.affiliation: Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. tueno@med.nihon-u.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ueno
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Kzunobu
authors.initials: K
authors.lastname: Tahira
authors.forename: Noboru
authors.initials: N
authors.lastname: Fukuda
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katsuya
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogihara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Makita
authors.forename: Akira
authors.initials: A
authors.lastname: Hata
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Norio
authors.initials: N
authors.lastname: Takahashi
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Hirawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umemura
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004198:Disease Susceptibility; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins