title: Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study.
abstract: OBJECTIVE
  The aim of this study was to compare preoperative planar scintimammography (SM) with high resolution dedicated breast camera (DBC) and conventional mammography in the detection of multifocal, multicentric and bilateral breast cancer and its impact on surgical planning.
  
  
  METHODS
  A series of 264 consecutive patients, 232 with breast cancer and 32 with benign lesions, underwent [(99m)Tc]tetrofosmin planar SM with a newly developed DBC (LumaGEM 3200S/12K, Gamma Medica-Ideas Inc.). Scintigraphic with mammography data were compared and correlated with histopathological findings.
  
  
  RESULTS
  At surgery, ipsilateral multifocal or multicentric breast cancer in 40 patients, invasive in 24 cases (group 1) and in situ in 16 (group 2) was ascertained, and synchronous bilateral breast cancer in 4 patients (group 3). Globally, SM was positive for cancer in 41 out of the 44 breast cancer patients (93.2%) and mammography was positive in 40 out of 44 (90.1%). SM revealed multifocal/multicentric disease in 87.5% of group 1/goup 2 patients and mammography in 47.5% (P<0.0005): SM detected a significantly higher number of additional invasive foci than mammography (89.6% vs 37.9%, P<0.0005); only SM revealed ipsilateral multifocality/multicentricity in 35% of cases. Bilaterality was detected by SM in 100% of group 3 patients and by mammography in 75%. Overall specificity was 88.2% for SM and 52.9% for mammography. SM correctly changed surgical management in 16% of cases.
  
  
  CONCLUSIONS
  DBC planar SM proved a more highly sensitive diagnostic method than mammography in the preoperative assessment of both ipsilateral multifocal/multicentric breast cancer and synchronous bilateral breast cancer. The procedure contributed to correctly changing patient surgical management in some cases, suggesting its wider use complementary to mammography.
authors.affiliation: Department of Nuclear Medicine, University of Sassari, Sassari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Spanu
authors.forename: F
authors.initials: F
authors.lastname: Chessa
authors.forename: G
authors.initials: G
authors.lastname: Battista Meloni
authors.forename: D
authors.initials: D
authors.lastname: Sanna
authors.forename: P
authors.initials: P
authors.lastname: Cottu
authors.forename: A
authors.initials: A
authors.lastname: Manca
authors.forename: S
authors.initials: S
authors.lastname: Nuvoli
authors.forename: G
authors.initials: G
authors.lastname: Madeddu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000000981:diagnostic imaging* / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies