Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators.
Active resolution of acute inflammation is a previously unrecognized interface between innate and adaptive immunity. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programmes that enable inflamed tissues to return to homeostasis. This Review presents new cellular and molecular mechanisms for the resolution of inflammation, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and protectins. These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence.
Serhan
Charles N
CN
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. cnserhan@zeus.bwh.harvard.edu
Chiang
Nan
N
Van Dyke
Thomas E
TE
D000818:Animals; D018957:CD59 Antigens / Q000502:physiology; D015777:Eicosanoids / Q000502:physiology; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives / Q000502:physiology; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000502:physiology; D044045:Lipoxins / Q000502:physiology; D009092:Mucous Membrane / Q000276:immunology / Q000382:microbiology; D015398:Signal Transduction
D018957:CD59 Antigens; D015777:Eicosanoids; D018836:Inflammation Mediators; D044045:Lipoxins; D015118:Eicosapentaenoic Acid