title: Effective chromosome pairing requires chromatin remodeling at the onset of meiosis.
abstract: During meiosis, homologous chromosomes (homologues) recognize each other and then intimately associate. Studies exploiting species with large chromosomes reveal that chromatin is remodeled at the onset of meiosis before this intimate association. However, little is known about the effect the remodeling has on pairing. We show here in wheat that chromatin remodeling of homologues can only occur if they are identical or nearly identical. Moreover, a failure to undergo remodeling results in reduced pairing between the homologues. Thus, chromatin remodeling at the onset of meiosis enables the chromosomes to become competent to pair and recombine efficiently.
authors.affiliation: John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colas
authors.forename: Peter
authors.initials: P
authors.lastname: Shaw
authors.forename: Pilar
authors.initials: P
authors.lastname: Prieto
authors.forename: Michael
authors.initials: M
authors.lastname: Wanous
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Spielmeyer
authors.forename: Rohit
authors.initials: R
authors.lastname: Mago
authors.forename: Graham
authors.initials: G
authors.lastname: Moore
mesh_terms: D042002:Chromatin Assembly and Disassembly; D023902:Chromosome Pairing; D032461:Chromosomes, Plant / Q000235:genetics*; D006570:Heterochromatin / Q000378:metabolism* / Q000648:ultrastructure; D011995:Recombination, Genetic; D014908:Triticum / Q000235:genetics*
chemical_list: D006570:Heterochromatin