title: Evaluation of the role of magnetization transfer imaging in prostate: a preliminary study.
abstract: Results of the preliminary study on the evaluation of the role of magnetization transfer imaging (MTI) of prostate in men who had raised prostate-specific antigen (PSA) (>4 ng/ml) or abnormal digital rectal examination (DRE) are reported. MT ratio (MTR) was calculated for 20 patients from the hyper- (normal) and hypo-intense regions (area suspicious of malignancy as seen on T2-weighted MRI) of the peripheral zone (PZ) and the central gland (CG) at 1.5 T. In addition, MTR was calculated for three healthy controls. Mean MTR was also calculated for the whole of the PZ (including hyper- and hypo-intense area) in all patients. Out of 20 patients, biopsy revealed malignancy in 12 patients. Mean MTR value (8.29+/-3.49) for the whole of the PZ of patients who were positive for malignancy on biopsy was statically higher than that observed for patients who were negative for malignancy (6.18+/-3.15). The mean MTR for the whole of the PZ of controls was 6.18+/-1.63 and is similar to that of patients who were negative for malignancy. Furthermore, for patients who showed hyper- (normal portion) and hypo-intense (region suspicious of malignancy) regions of the PZ, the MTR was statistically significantly different. These preliminary results reveal the potential role of MT imaging in the evaluation of prostate cancer.
authors.affiliation: Department of NMR, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Virendra
authors.initials: V
authors.lastname: Kumar
authors.forename: Naranamangalam R
authors.initials: NR
authors.lastname: Jagannathan
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kumar
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.forename: Siddhartha D
authors.initials: SD
authors.lastname: Gupta
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Hemal
authors.forename: Narmada P
authors.initials: NP
authors.lastname: Gupta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010808:Physical Examination; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis*
chemical_list: D017430:Prostate-Specific Antigen