Decreased serum brain-derived neurotrophic factor in trained men.
The purpose of this study was to clarify the effect of physical activity on the level of serum brain-derived neurotrophic factor (BDNF). The serum BDNF level in trained men who have participated in regular sport activity (n=12) was compared to that in sedentary subjects (n=14). The physical activity levels expressed as total energy expenditure, move-related energy expenditure and walking count in the trained were significantly higher than those in the sedentary. The serum BDNF level in the trained men was found to be lower than that in the sedentary (19.54+/-4.53 ng/ml vs. 23.63+/-2.94 ng/ml, respectively, P<0.01). The serum BDNF level showed a significant negative correlation with daily total energy expenditure (r=-0.507, P<0.05), movement-related energy expenditure (r=-0.503, P<0.05), and walking count (r=-0.480, P<0.05). These results may suggest that vigorous habitual physical activity decrease the serum BDNF level.
Nofuji
Yu
Y
Graduate School of Human-Environment Studies, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.
Suwa
Masataka
M
Moriyama
Yoshihiko
Y
Nakano
Hiroshi
H
Ichimiya
Atsushi
A
Nishichi
Reiko
R
Sasaki
Haruka
H
Radak
Zsolt
Z
Kumagai
Shuzo
S
D000328:Adult; D000886:Anthropometry; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D013177:Sports; D016138:Walking / Q000502:physiology; D055815:Young Adult
D019208:Brain-Derived Neurotrophic Factor