Fulminant type 1 diabetes as a model of nature to explore the role of C-peptide.
Patients with fulminant type 1 diabetes almost completely lack C-peptide even soon after the onset of the disease, and the deficiency continues for the rest of their life. Thus, fulminant type 1 diabetes could serve as a good model of nature to explore the physiological role of C-peptide. For example, patients with fulminant type 1 diabetes have diabetic chronic complications more frequently than those with classical autoimmune type 1 diabetes 5 years after the onset of diabetes, and the higher prevalence could be partly attributable to the complete lack of C-peptide in fulminant type 1 diabetes.
Murase-Mishiba
Yuko
Y
First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-Machi, Takatsuki 569-8686, Japan.
Imagawa
A
A
Hanafusa
Toshiaki
T
D015415:Biomarkers; D002096:C-Peptide / Q000097:blood* / Q000172:deficiency*; D048909:Diabetes Complications / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000145:classification; D003925:Diabetic Angiopathies / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion
D015415:Biomarkers; D002096:C-Peptide; D007328:Insulin