title: Unsuccessful induction of endometriosis in female rhesus macaques (Macaca mulatta).
abstract: OBJECTIVE
  The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes.
  
  
  METHODS
  Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed.
  
  
  RESULTS
  Neither macroscopic observation nor histological analysis revealed any endometriotic lesions.
  
  
  CONCLUSIONS
  This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.
authors.affiliation: Department of Gynecology, Medical School, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Defrère
authors.forename: Jean
authors.initials: J
authors.lastname: Squifflet
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lousse
authors.forename: Anne
authors.initials: A
authors.lastname: Van Langendonckt
authors.forename: Reinaldo
authors.initials: R
authors.lastname: González-Ramos
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Christine
authors.initials: C
authors.lastname: Jérome
authors.forename: Luc
authors.initials: L
authors.lastname: Delattre
authors.forename: Jacques
authors.initials: J
authors.lastname: Donnez
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Dehoux
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004195:Disease Models, Animal; D004715:Endometriosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000473:pathology* / Q000601:surgery