title: Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course.
abstract: Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.
authors.affiliation: Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Via del Brennero 2, I-56127 Pisa, Italy. freer@biomed.unipi.it
authors.forename: Giulia
authors.initials: G
authors.lastname: Freer
authors.forename: Donatella
authors.initials: D
authors.lastname: Matteucci
authors.forename: Paola
authors.initials: P
authors.lastname: Mazzetti
authors.forename: Francesca
authors.initials: F
authors.lastname: Tarabella
authors.forename: Enrica
authors.initials: E
authors.lastname: Ricci
authors.forename: Leonia
authors.initials: L
authors.lastname: Bozzacco
authors.forename: Antonio
authors.initials: A
authors.lastname: Merico
authors.forename: Mauro
authors.initials: M
authors.lastname: Pistello
authors.forename: Luca
authors.initials: L
authors.lastname: Ceccherini-Nelli
authors.forename: Mauro
authors.initials: M
authors.lastname: Bendinelli
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D002415:Cats; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000821:virology*; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy* / Q000821:virology; D007111:Immunity, Cellular; D016089:Immunodeficiency Virus, Feline / Q000276:immunology* / Q000502:physiology; D007167:Immunotherapy / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D019562:Viral Load; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D015164:Vaccines, Inactivated; D014765:Viral Vaccines