title: Nonrigid registration of multiple sclerosis brain images using lesion inpainting for morphometry or lesion mapping.
abstract: Morphometric studies of medical images often include a nonrigid registration step from a subject to a common reference. The presence of white matter multiple sclerosis lesions will distort and bias the output of the registration. In this article, we present a method to remove this bias by filling such lesions to make the brain look like a healthy brain before the registration. We finally propose a dedicated method to fill the lesions and present numerical results showing that our method outperforms current state of the art method.
authors.affiliation: Department of Neurology, University of California, San Francisco, 94107, USA.
authors.forename: Michaël
authors.initials: M
authors.lastname: Sdika
authors.forename: Daniel
authors.initials: D
authors.lastname: Pelletier
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D003952:Diagnostic Imaging; D006801:Humans; D007089:Image Enhancement; D021621:Imaging, Three-Dimensional / Q000379:methods; D009103:Multiple Sclerosis / Q000175:diagnosis*; D012042:Registries; D018709:Statistics, Nonparametric