[Study progress on the mode of action of praziquantel against schistosomes].
Praziquantel is the only effective drug of choice against five human species of schistosomes. Main advantages of praziquantel include convenient oral administration, high safety and efficacy as well as short treatment course. To better understand the mode of action of praziquantel against schistosomes would be helpful for further development of new broad-spectrum anthelminthics. This paper summarizes the 30 years' research progress on the mode of action of the drug against schistosomes proceeded by domestic and abroad laboratories.
Xiao
Shu-Hua
SH
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China.
D000818:Animals; D006801:Humans; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012547:Schistosoma / Q000187:drug effects* / Q000378:metabolism; D012552:Schistosomiasis / Q000469:parasitology / Q000517:prevention & control; D012556:Schistosomicides / Q000494:pharmacology* / Q000627:therapeutic use
D012556:Schistosomicides; D011223:Praziquantel