title: [Advance of research on SDF-1/CXCR4 axis and angiogenesis in leukemia--review].
abstract: The study on biological effects of SDF-1/CXCR4 axis composed of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 is progressing rapidly in the recent years. The SDF-1/CXCR4 axis plays an important role in occurrence and development of tumors and closely correlate with angiogenesis of tumors. This review focuses the progress of study on SDF-1/CXCR4 axis and angiogenesis in leukemia including SDF-1/ and its receptor CXCR4, the expression of SDF-1/CXCR4 axis in leukemic cells, the mechanism of relation between SDF-1/CXCR4 axis and angiogenesis in leukemia, the application of inhibitors against SDF-1/CXCR4 in treatment of angiogenesis and so on.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China.
authors.forename: Cui-Hua
authors.initials: CH
authors.lastname: Bao
authors.forename: Qi-Tu
authors.initials: QT
authors.lastname: He
mesh_terms: D054377:Chemokine CXCL12 / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D019718:Receptors, CXCR4 / Q000378:metabolism* / Q000502:physiology
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4