title: Challenges to evidence-based prescribing in clinical practice.
abstract: Although there appears to be widespread support of evidence-based medicine as a basis for rational prescribing, the challenges to it are significant and often justified. A multitude of factors other than evidence drive clinical decision-making, including patient preferences and social circumstances, presence of disease-drug and drug-drug interactions, clinical experience, competing demands from more pressing clinical conditions, marketing and promotional activity, and system-level drug policies.
authors.affiliation: Applied Health Research Centre, Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mamdani
authors.forename: Andrew
authors.initials: A
authors.lastname: Ching
authors.forename: Brian
authors.initials: B
authors.lastname: Golden
authors.forename: Magda
authors.initials: M
authors.lastname: Melo
authors.forename: Ulrich
authors.initials: U
authors.lastname: Menzefricke
mesh_terms: D011307:Drug Prescriptions / Q000592:standards*; D019317:Evidence-Based Medicine / Q000379:methods / Q000592:standards* / Q000639:trends; D005194:Family Practice / Q000379:methods / Q000592:standards* / Q000639:trends; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards