title: SPIR01 and SPIR02: a two-year 1-day point prevalence multicenter study of infections in intensive care units in Piedmont, Italy.
abstract: This study reports the results of a one-day point prevalence study of infections performed in 2001 (SPIR01) and 2002 (SPIR02) in a Regional network of ICUs in Piedmont, Italy. The study aims were to illustrate the overall proportion of infected patients and the rate of ICU-acquired infections. Mortality rate was evaluated three weeks after the study days. Resistance pattern of Staphylococcus aureus, coagulase negative Staphylococci and Pseudomonas aeruginosa were recorded. The primary end-point of the study was to document the prevalence and associated risk factors of the ICU-acquired infections, and the impact of infections on mortality. The prevalence of ICU-acquired infection was 30% in SPIR01, and 38.3% in SPIR02. The rate of methicillin-resistance was high among isolates of Staphylococcus aureus and coagulase-negative Staphylococci. The prevalence of ICU-acquired infections was lower than that reported in the EPIC study. In our experience, this Regional survey stimulated further research and collaboration to improve the prophylaxis, diagnosis and treatment of ICU-acquired infections.
authors.affiliation: Università di Torino, Dipartimento di Discipline Medico-Chirurgiche, Sezione di Malattie Infettive, Ospedale Amedeo di Savoia, Italy. francescogiuseppe.derosa@unito.it
authors.forename: Francesco G
authors.initials: FG
authors.lastname: De Rosa
authors.forename: Silvia
authors.initials: S
authors.lastname: Garazzino
authors.forename: Sabrina
authors.initials: S
authors.lastname: Audagnotto
authors.forename: Olivia
authors.initials: O
authors.lastname: Bargiacchi
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Zeme
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gramoni
authors.forename: Bruno
authors.initials: B
authors.lastname: Barberis
authors.forename: V Marco
authors.initials: VM
authors.lastname: Ranieri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Perri
mesh_terms: D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007558:Italy / Q000453:epidemiology; D015995:Prevalence; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D012307:Risk Factors