title: The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease.
abstract: BACKGROUND
  We aimed to clarify the relationship between HLA-DRB1(*)1501 and anti-glomerular basement membrane (GBM) antibody-mediated disease in Japanese patients.
  
  
  METHODS
  Samples were collected from 16 anti-GBM antibody-positive patients who were admitted to our department or related hospitals from December 1990 to October 2005. We analysed clinical and laboratory data, kidney biopsy findings, and the HLA-DR phenotypes and HLA-DRB1 alleles of the patients.
  
  
  RESULTS
  Among the 16 patients, 15 had HLA-DR15 [the phenotype frequency (PF) was 93.8%], 7 were positive for DR4 (the PF was 43.8%) and 5 were positive for DR9 (the PF was 31.3%). The allele frequency of HLA-DRB1(*)1501 was 46.4% (13/28), which was significantly different from Japanese controls (11.6%) (P < 0.001). In contrast, the frequency of HLA-DRB1(*)1502 was not different from controls (0/28). The odds ratio of HLA-DRB1(*)1501 in these patients was 6.4 (95% CI: 2.4-16.5).
  
  
  CONCLUSIONS
  The present study demonstrated that Japanese patients with anti-GBM antibody-mediated disease are very likely to carry the HLA-DRB1(*)1501 but not the HLA-DRB1(*)1502 allele.
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Kitagawa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Imai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komatsuda
authors.forename: Nobuki
authors.initials: N
authors.lastname: Maki
authors.forename: Hideki
authors.initials: H
authors.lastname: Wakui
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hiki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sugiyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019867:Anti-Glomerular Basement Membrane Disease / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D044466:Asian People / Q000235:genetics; D001323:Autoantibodies / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D050533:Glomerular Basement Membrane / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen; C051951:antiglomerular basement membrane antibody