title: Telmisartan in the treatment of hypertension.
abstract: BACKGROUND
  Telmisartan is an orally active angiotensin II receptor antagonist prescribed once daily.
  
  
  OBJECTIVE
  To evaluate the efficacy of telmisartan on blood pressure control, and on other end points, when given as monotherapy or in combination.
  
  
  METHODS
  Review of published literature.
  
  
  RESULTS
  Telmisartan produces more effective control of blood pressure over 24 h, especially in the last 6 h of the dosing interval, compared with other antihypertensive agents. It also possesses pleiotrophic effects on lipid and glucose metabolism, but lacks evidence of efficacy in reducing vascular events.
  
  
  CONCLUSIONS
  Clinical outcome trials expected to report in 2008 will provide hard end points that may demonstrate advantages of telmisartan as monotherapy, or in combination with angiotensin-converting enzyme inhibitors, for managing hypertension.
authors.affiliation: Sheffield Teaching Hospitals NHS Foundation Trust, Department of Geriatric Medicine, Sir Robert Hadfield Wing, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK.
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Rosario
authors.forename: Timothy James
authors.initials: TJ
authors.lastname: Hendra
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D050356:Lipid Metabolism / Q000187:drug effects; D000077333:Telmisartan; D016896:Treatment Outcome
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D000077333:Telmisartan