Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing.
Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans.
Jacobsen
Mette D
MD
Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK.
Davidson
Amanda D
AD
Li
Shu-Ying
SY
Shaw
Duncan J
DJ
Gow
Neil A R
NA
Odds
Frank C
FC
D002176:Candida albicans / Q000235:genetics; D041022:Candida tropicalis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D006239:Haplotypes; D006801:Humans; D016533:Mycological Typing Techniques; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic