title: Evaluation of a new matrix-free laser desorption/ionization method through statistic studies: comparison of the DIAMS (desorption/ionization on self-assembled monolayer surface) method with the MALDI and TGFA-LDI techniques.
abstract: This work demonstrates that the desorption/ionization on self-assembled monolayer surface (DIAMS) mass spectrometry, a recent matrix-free laser desorption/ionization (LDI) method based on an organic target plate, is as statistically repeatable and reproducible as matrix assisted laser desorption ionization (MALDI) and thin gold film-assisted laser desorption/ionization (TGFA-LDI) mass spectrometries. On lipophilic DIAMS of target plates with a mixture of glycerides, repeatability/reproducibility has been estimated at 15 and 30% and the relative detection limit has been evaluated at 0.3 and 3 pmol, with and without NaI respectively. Salicylic acid and its d(6)-isomer analysis confirm the applicability of the DIAMS method in the detection of compounds of low molecular weight.
authors.affiliation: Université d'Angers, CIMA CNRS, UFR Sciences, 2 Bd Lavoisier, 49045 Angers, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Bounichou
authors.forename: Lionel
authors.initials: L
authors.lastname: Sanguinet
authors.forename: Kamal
authors.initials: K
authors.lastname: Elouarzaki
authors.forename: Olivier
authors.initials: O
authors.lastname: Alévêque
authors.forename: Marylène
authors.initials: M
authors.lastname: Dias
authors.forename: Eric
authors.initials: E
authors.lastname: Levillain
authors.forename: David
authors.initials: D
authors.lastname: Rondeau