Comparison of neopterin levels in patients with coronary artery ectasia versus patients with obstructive coronary artery disease.
OBJECTIVE
Inflammation has been reported as an important component of vascular aneurysm formation, as found in obstructive vascular disorder. Neopterin is produced by activated macrophages and is thought to represent a marker of immune activation and macrophage activity. The plasma neopterin levels were investigated in coronary artery ectasia (CAE) patients to investigate the role of inflammation.


METHODS
The study population consisted of three groups: the first consisted of 28 patients with isolated CAE without stenotic lesion; the second of 27 patients with obstructive coronary artery disease (O-CAD) without CAE; and the third group of 15 control subjects with normal coronary arteries (NCA). Plasma soluble neopterin levels were measured in all patients and control subjects using commercially available enzyme-linked immunosorbent assay kits.


RESULTS
Plasma neopterin levels were found to be significantly higher in patients with isolated CAE compared with control subjects with angiographically NCA (18.5 +/- 8.8 versus 8.7 +/- 2.6 nmol/L, respectively, P = 0.006). Although neopterin levels were higher in patients with CAE than in patients with O-CAD, they did not reach the statistically significant levels (18.5 +/- 8.8 versus 16.8 +/- 8.2 nmol/L, respectively, P = 0.77). Patients with O-CAD had significantly higher levels of neopterin compared with subjects with angiographically NCA (16.8 +/- 8.2 versus 8.7 +/- 2.6 nmol/L, respectively, P = 0.03). The mean serum neopterin levels in patients with single-vessel, two-vessel, and diffuse ectasia were as follows: 17.4 +/- 9.9 nmol/L, 19.5 +/- 8.9 nmol/L, and 20 +/- 5.5 nmol/L, respectively (P = 0.4).


CONCLUSIONS
Patients with isolated CAE have raised levels of neopterin compared with patients with NCA, showing the possible role of inflammatory processes (monocyte/macrophage activity) in the higher levels of neopterin in patients with O-CAD.
Sahin
Mehmet
M
Department of Internal Medicine, Suleyman Demirel University, Isparta, Turkey.
Varol
Ercan
E
Ozaydin
Mehmet
M
Altinbas
Ahmet
A
Aydin
Osman
O
Aslan
Suleyman M
SM
Dogan
Abdullah
A
Kaya
Selçuk
S
D000328:Adult; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000737:chemistry* / Q000473:pathology*; D004108:Dilatation, Pathologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019798:Neopterin / Q000097:blood*; D012044:Regression Analysis
D019798:Neopterin