title: Decreased serum brain-derived neurotrophic factor in trained men.
abstract: The purpose of this study was to clarify the effect of physical activity on the level of serum brain-derived neurotrophic factor (BDNF). The serum BDNF level in trained men who have participated in regular sport activity (n=12) was compared to that in sedentary subjects (n=14). The physical activity levels expressed as total energy expenditure, move-related energy expenditure and walking count in the trained were significantly higher than those in the sedentary. The serum BDNF level in the trained men was found to be lower than that in the sedentary (19.54+/-4.53 ng/ml vs. 23.63+/-2.94 ng/ml, respectively, P<0.01). The serum BDNF level showed a significant negative correlation with daily total energy expenditure (r=-0.507, P<0.05), movement-related energy expenditure (r=-0.503, P<0.05), and walking count (r=-0.480, P<0.05). These results may suggest that vigorous habitual physical activity decrease the serum BDNF level.
authors.affiliation: Graduate School of Human-Environment Studies, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Nofuji
authors.forename: Masataka
authors.initials: M
authors.lastname: Suwa
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Moriyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ichimiya
authors.forename: Reiko
authors.initials: R
authors.lastname: Nishichi
authors.forename: Haruka
authors.initials: H
authors.lastname: Sasaki
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Radak
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kumagai
mesh_terms: D000328:Adult; D000886:Anthropometry; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D013177:Sports; D016138:Walking / Q000502:physiology; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor