title: Metal-mediated formation of carbon-halogen bonds.
abstract: Organic halides represent basic starting materials for numerous metal-catalyzed organic transformations. Generally, the carbon-halogen is broken in the first step, that is, an oxidative addition reaction, of the catalytic cycle. On the other hand, very little is known about the reverse reaction, carbon-halogen reductive elimination from a transition-metal center. In this Concept article, we describe the examples of C(sp(3))-halide and C(sp(2))-halide reductive-elimination reactions which demonstrate that this type of reactivity can be quite common in organometallic chemistry. Although the thermodynamic driving force for the formation of carbon-halogen bonds is relatively small, the kinetic barrier for these reactions can also be low. Thus, C-halide reductive elimination can compete favorably with the more established organic transformations, such as C-C reductive elimination.
authors.affiliation: School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel. avigal@post.tau.ac.il
authors.forename: Arkadi
authors.initials: A
authors.lastname: Vigalok