title: Organophosphorus pesticide poisoning: cases and developments.
abstract: Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy. In the Western world, the occurrence of organophosphorus poisoning is less prevalent due to the declining availability of organophosphate pesticides, which could render the recognition of this particular type of intoxication and its specific treatment more difficult. In this article we discuss some recent developments and treatment dilemmas, illustrated by cases from our clinic, followed by a review of the current recommendations in the treatment of organophosphate poisoning.
authors.affiliation: Department of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands. h.aardema@int.umcg.nl
authors.forename: H
authors.initials: H
authors.lastname: Aardema
authors.forename: J H J M
authors.initials: JH
authors.lastname: Meertens
authors.forename: J J M
authors.initials: JJ
authors.lastname: Ligtenberg
authors.forename: O M
authors.initials: OM
authors.lastname: Peters-Polman
authors.forename: J E
authors.initials: JE
authors.lastname: Tulleken
authors.forename: J G
authors.initials: JG
authors.lastname: Zijlstra
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008297:Male; D062025:Organophosphate Poisoning; D010091:Oximes / Q000627:therapeutic use; D010278:Parathion / Q000506:poisoning; D010575:Pesticides / Q000506:poisoning*; D011041:Poisoning / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D013405:Suicide; D013406:Suicide, Attempted
chemical_list: D007306:Insecticides; D010091:Oximes; D010575:Pesticides; D010278:Parathion