Aging by epigenetics--a consequence of chromatin damage?
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
Sedivy
John M
JM
Brown University, Division of Biology and Medicine, Laboratories for Molecular Medicine, 70 Ship Street, Providence, RI 02903, USA. john_sedivy@brown.edu
Banumathy
Gowrishankar
G
Adams
Peter D
PD
D000375:Aging / Q000235:genetics*; D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000473:pathology*; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D006801:Humans; D011371:Progeria / Q000473:pathology; D015003:Yeasts / Q000502:physiology
D002843:Chromatin