title: Human cortical bone: the SINUPROS model.
abstract: Several modelizations have been investigated on human cortical bone in our team and we have often observed that the introduction of a new geometrical parameter induces significant perturbations on the numerical values obtained with previous models. We have therefore decided to take into account the totality of all possible parameters in a modelization which is physically and physiologically plausible. In order to do this, we have analyzed the architecture of cortical bone and exhibited all parameters that occur. To determine physical properties at each architectural level, the best adapted tool is without any doubt the mathematical theory of homogenization. All the necessary algorithms have been implemented into SINUPROS software (websites of the Universities). Its main interest is the evaluation of macroscopic physical properties for a given configuration. It can also be used to seek, by successive tests, configurations corresponding to properties experimentally measured. Computation time being too high (10 to 45 minutes according to tested configurations), a fast version based on approximation theory has been developed and thus the obtaining of the results is immediate. The researched configuration being thus obtained, it has then to be validated by the original version.
authors.affiliation: University of Craiova, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Predoi-Racila
authors.forename: J M
authors.initials: JM
authors.lastname: Crolet
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000502:physiology*; D003094:Collagen / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D012984:Software; D013314:Stress, Mechanical
chemical_list: D003094:Collagen