Cardiac resynchronization: insight from experimental and computational models.
Cardiac resynchronization therapy (CRT) is a promising therapy for heart failure patients with a conduction disturbance, such as left bundle branch block. The aim of CRT is to resynchronize contraction between and within ventricles. However, about 30% of patients do not respond to this therapy. Therefore, a better understanding is needed for the relation between electrical and mechanical activation. In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT.
Kerckhoffs
R C P
RC
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0412, USA.
Lumens
J
J
Vernooy
K
K
Omens
J H
JH
Mulligan
L J
LJ
Delhaas
T
T
Arts
T
T
McCulloch
A D
AD
Prinzen
F W
FW
D002037:Bundle-Branch Block / Q000503:physiopathology* / Q000628:therapy; D002304:Cardiac Pacing, Artificial; D005246:Feedback; D020342:Finite Element Analysis; D006329:Heart Conduction System; D006333:Heart Failure / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D040542:Mechanotransduction, Cellular; D008955:Models, Cardiovascular