Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes.
Attentional deficits are common and significant sequelae of pediatric traumatic brain injury (TBI). However, little is known about how the underlying neural processes that support different components of attention are affected. The present study examined brain activation patterns using fMRI in a group of young children who sustained a TBI in early childhood (n = 5; mean age = 9.4), and a group of age-matched control children with orthopedic injuries (OI) (n = 8) during a continuous performance task (CPT). Four children in the TBI group had moderate injuries, and one had a severe injury. Performance on the CPT task did not differ between groups. Both TBI and OI children activated similar networks of brain regions relevant to sustained attention processing, but the TBI group demonstrated several areas of significantly greater activation relative to controls, including frontal and parietal regions. These findings of over-activation of the relevant attention network in the TBI group contrast with those obtained in imaging studies of Attention-Deficit/Hyperactivity Disorder where under-activation of the attention network has been documented. This study provides evidence that young children's brains function differently following a traumatic brain injury, and that these differences persist for years after the injury.
Kramer
Megan E
ME
Department of Psychology, University of Cincinnati, Cincinnati, Ohio 45221-0376, USA. kramerm2@email.uc.edu
Chiu
C-Y Peter
CY
Walz
Nicolay Chertkoff
NC
Holland
Scott K
SK
Yuan
Weihong
W
Karunanayaka
Prasanna
P
Wade
Shari L
SL
D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology; D012044:Regression Analysis
D010100:Oxygen