AML1 and Evi1: coconspirators in MDS/AML?
In this issue of Blood, Watanabe-Okochi and colleagues use a mouse bone marrow transplantation model to demonstrate that mutant alleles of AML1 (RUNX1) can initiate a myelodysplastic syndrome (MDS) that progresses to acute myelogenous leukemia (AML) in association with overexpression of Evi1.
Graubert
Timothy
T
Washington University School of Medicine, USA.