Change in prostate specific antigen following androgen stimulation is an independent predictor of prostate cancer diagnosis.
OBJECTIVE
We tested the hypothesis that a single exogenous androgen injection in men with low prostate specific antigen would provoke a differential prostate specific antigen response that would correlate with the presence and volume of cancer at biopsy.


METHODS
Following institutional review board approval 40 men with prostate specific antigen between 2.5 and 4.0 ng/ml were given 1 intramuscular injection of 400 mg testosterone cypionate at the start of the study. Prostate specific antigen and early morning serum testosterone were measured at baseline, 48 hours, and weeks 1, 2 and 4. All men underwent 12-core transrectal ultrasound guided biopsy at week 4.


RESULTS
Of the 40 men 18 (45%) were diagnosed with prostate cancer. The mean change in prostate specific antigen from baseline to 4 weeks was 3.1 to 3.4 ng/ml (9.7%) in men found to have benign findings on biopsy compared to a mean increase of 2.9 to 3.8 ng/ml (29%) in those with prostate cancer (p = 0.006). The change in prostate specific antigen following androgen stimulation was significantly associated with the percent of tissue involved with cancer and it was an independent predictor of cancer diagnosis on univariate and multivariate analysis.


CONCLUSIONS
An increase in prostate specific antigen following androgen stimulation in men with prostate specific antigen between 2.5 and 4.0 ng/ml was highly predictive of the subsequent diagnosis of prostate cancer and it correlated with disease volume. If these findings are corroborated, prostate specific antigen provocation may become an important strategy to identify men at risk for harboring prostate cancer and minimize the number undergoing unnecessary biopsies.
Svatek
Robert S
RS
Department of Urology, Dallas Veterans Administration Hospital, Dallas, Texas, USA.
Shulman
Michael J
MJ
Benaim
Elie A
EA
Rogers
Thomas E
TE
Margulis
Vitaly
V
D000368:Aged; D000728:Androgens / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood* / Q000187:drug effects*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
D000728:Androgens; D013739:Testosterone; D017430:Prostate-Specific Antigen; C016131:testosterone 17 beta-cypionate