Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats.
IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions.
Cata
Juan P
JP
The Department of Anesthesiology and Pain Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Weng
Han-Rong
HR
Dougherty
Patrick M
PM
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D006358:Hot Temperature; D007278:Injections, Spinal; D019409:Interleukin-15 / Q000008:administration & dosage / Q000494:pharmacology*; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010146:Pain / Q000523:psychology; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D019409:Interleukin-15; D007376:Interleukin-2