Lithium-induced nephrotic syndrome in a prepubertal boy.
Lithium carbonate has been recognized to induce several renal side effects, including the nephrotic syndrome. This is a report of an 11-year-old, prepubertal boy with a mood disorder treated with lithium who presented with edema, bilateral pulmonary effusions, proteinuria, and hypoalbuminemia. Renal biopsy revealed pathologic changes consistent with minimal change disease. These symptoms normalized after lithium discontinuation.
Petersen
Carl E
CE
Navy Medicine Manpower Personnel Training and Education Command, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. carl.petersen@med.navy.mil
Amaral
Sandra
S
Frosch
Emily
E
D018692:Antimanic Agents / Q000633:toxicity*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000188:drug therapy; D001706:Biopsy; D002648:Child; D015897:Comorbidity; D004359:Drug Therapy, Combination; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D016651:Lithium Carbonate / Q000633:toxicity*; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis / Q000188:drug therapy*; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000473:pathology; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000473:pathology
D018692:Antimanic Agents; D016651:Lithium Carbonate