Humoral phototransduction: light transportation in the blood, and possible biological effects.
In our measurements plasma and, especially, the main plasma protein, albumin, exhibits a long-lasting light-induced luminescence, which should be capable of transporting light along the blood circulation. Moreover, albumin shows intense fluorescence, with emission at 337 nm, which is controlled by bilirubin. Furthermore, it is known that tryptophan decarboxylase, the last step of serotonin formation, is directly activated by light, with a maximum at 337 nm. As a hypothesis, we propose that light-induced luminescence of plasma components, such as albumin and free radicals, transports ambient light along the blood vessels. This emission could have photochemical and photobiological effects, e.g., photomodulation of enzymes. Albumin fluorescence emission could stimulate serotonin formation at 337 nm, modulated by bilirubin. Such mechanisms could be involved in the action of light therapy on serotonin formation, melatonin suppression and circadian rhythms, both in the pathophysiology of seasonal affective disorder and major depression, and in blood pressure regulation via photovasorelaxation. The proposed model can be called humoral phototransduction.
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D000418:Albumins / Q000378:metabolism; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism; D001794:Blood Pressure; D005609:Free Radicals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007834:Lasers; D008027:Light; D008954:Models, Biological; D008962:Models, Theoretical; D010789:Phototherapy; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors; D014785:Vision, Ocular
D000418:Albumins; D005609:Free Radicals; D012701:Serotonin; D001142:Aromatic-L-Amino-Acid Decarboxylases