E-cadherin expression in canine cutaneous histiocytomas.
Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.
Baines
S J
SJ
Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
McInnes
E F
EF
McConnell
I
I
D000818:Animals; D000911:Antibodies, Monoclonal; D015820:Cadherins / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D004283:Dog Diseases / Q000276:immunology* / Q000473:pathology; D004285:Dogs; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D015972:Gene Expression Regulation, Neoplastic; D018219:Histiocytoma, Benign Fibrous / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
D000911:Antibodies, Monoclonal; D015820:Cadherins