Activated protein C ratio, plasma tissue factor activity and activated factor VII in Chinese patients with coronary heart disease.
OBJECTIVE
There is close relationship between abnormal coagulation system and progression of coronary heart disease (CHD), our purpose is to evaluate the contribution of hematologic factors and some other risk factors to the development of coronary heart disease (CHD) in Chinese population.


METHODS
56 patients with CHD at admission and 54 controls were enrolled. Plasma levels of protein C, free protein S, total protein S, thrombomodulin, activated factor VII (FVIIa), factor VII:Ag, P-selectin, tissue-type plasminogen activator, plasminogen activator inhibitor-1 were measured by enzyme linked immunosorbent assay, activity of tissue factor (aTF) by chromogenic activity assay, and activated protein C (APC) ratio, prothrombin time, aPTT, fibrinogen, D-dimmer and thrombin time by full-automated coagulation analyzer.


RESULTS
Compared with controls, plasma level of thrombomodulin, FVIIa, factor VII:Ag and aTF were raised in CHD group (p<0.05, 0.001, 0.05, and 0.05, respectively). The average APC ratio in CHD group was lower than that in controls (p<0.001). The result of binary logistic regression analysis showed that activated factor VII (OR2.680, 95%CI1.539-4.665) and tissue factor activity (OR1.019, 95%CI1.004-1.035) were risk factors and high density lipoprotein (OR0.008, 95%CI0-0.478) and activated protein C ratio (OR0.001, 95%CI0-0.011) were protective factors for CHD.


CONCLUSIONS
Low activated protein C ratio, elevated tissue factor activity and increased activated factor VII in plasma may contribute to development of coronary heart disease.
He
W J
WJ
Institute of Hematology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. hwjsun@163.com
Hu
Yu
Y
Zhang
X P
XP
Hong
M
M
Guo
T
T
Wei
W N
WN
Song
S J
SJ
D044466:Asian People / Q000208:ethnology; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000097:blood* / Q000208:ethnology; D004797:Enzyme-Linked Immunosorbent Assay; D015942:Factor VIIa / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011486:Protein C / Q000378:metabolism*; D017293:Protein S / Q000378:metabolism; D018180:Thrombomodulin / Q000097:blood; D013925:Thromboplastin / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000097:blood
D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; C051321:SERPINE1 protein, human; D018180:Thrombomodulin; D013925:Thromboplastin; D015942:Factor VIIa; D010959:Tissue Plasminogen Activator