title: Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD).
abstract: OBJECTIVE
  To evaluate changes on cutaneous microangiopathy in chronic venous disorder (CVD) after use of Cirkan [venotonic drug containing Ruscus aculeatus (plant extract), hesperidine methylchalcone (flavonoid) and vitamin C], elastic compression stockings (ECS) or no treatment for four weeks.
  
  
  METHODS
  Fifty-five female patients (85 legs), 25 to 57 years, with at least one limb classified as C2,s or C2,3,s (CEAP classification), were allocated consecutively, according to entrance order, in these three groups. Ten healthy women age-matched were also investigated. Using orthogonal polarization spectral technique (noninvasive method), measurements of functional capillary density (FCD, number of capillaries with flowing red blood cells/mm(2)), capillary morphology (CM, % of abnormal capillaries/mm(2)) and diameters (mum) of dermal papilla (DDP), capillary bulk (DCB) and capillary limb (CD) were obtained on the medial perimalleolar region and later analyzed using CapImage software.
  
  
  CONCLUSIONS
  CVD patients showed significant changes on CD and CM compared to healthy subjects in agreement with our previous findings (J Vasc Surg 43:1037-1044, 2006). On Cirkan-treated patients, after 4 weeks, CD decreased on both limbs and CM improved on the left one, suggesting an amelioration of the chronic venous hypertension. No significant changes could be detected on other patient groups. These results confirm the existence of microcirculatory dysfunction in early stages of CVD, probably due to post-capillary hypertension, and further support the venotonic action of Cirkan.
authors.affiliation: Laboratory for Research in Microcirculation, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. carmenporto@terra.com.br
authors.forename: Carmen Lucia
authors.initials: CL
authors.lastname: Lascasas-Porto
authors.forename: Ana Letícia M
authors.initials: AL
authors.lastname: Milhomens
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Virgini-Magalhães
authors.forename: Fabiano F A
authors.initials: FF
authors.lastname: Fernandes
authors.forename: Fernando L
authors.initials: FL
authors.lastname: Sicuro
authors.forename: Eliete
authors.initials: E
authors.lastname: Bouskela
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D002196:Capillaries / Q000473:pathology / Q000503:physiopathology; D002918:Chymotrypsin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004338:Drug Combinations; D004487:Edema / Q000473:pathology / Q000628:therapy; D005260:Female; D006569:Hesperidin / Q000627:therapeutic use; D006801:Humans; D007866:Leg / Q000473:pathology / Q000503:physiopathology; D008833:Microcirculation / Q000503:physiopathology*; D008875:Middle Aged; D010840:Phytosterols / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D053828:Stockings, Compression; D016896:Treatment Outcome; D014357:Trypsin / Q000627:therapeutic use; D014689:Venous Insufficiency / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D020246:Venous Thrombosis / Q000473:pathology / Q000628:therapy
chemical_list: D004338:Drug Combinations; D010840:Phytosterols; D010936:Plant Extracts; C021980:hesperidine methylchalcone, ruscus aculeatus, vitamin C; D006569:Hesperidin; D002918:Chymotrypsin; D014357:Trypsin; D001205:Ascorbic Acid