title: Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory.
abstract: Previous studies have shown that medial prefrontal cortical regions, such as the anterior cingulate cortex (ACC), play a key role in the expression of remote spatial and contextual memory. To evaluate whether this role is conserved in hippocampal-independent tasks we trained mice in the conditioned taste aversion (CTA) paradigm. Lidocaine-induced inactivation of the ACC blocked the expression of CTA tested one month (remote), but not one day (recent), after conditioning with either a weak or strong unconditioned stimulus (US). These data suggest that the ACC may play a conserved role in remote memory, regardless of memory strength or content.
authors.affiliation: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto M5G 1X8, Canada.
authors.forename: Hoi Ki
authors.initials: HK
authors.lastname: Ding
authors.forename: Cátia M
authors.initials: CM
authors.lastname: Teixeira
authors.forename: Paul W
authors.initials: PW
authors.lastname: Frankland
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D006179:Gyrus Cinguli / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D008568:Memory; D051379:Mice; D013649:Taste
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine