Mathematical biodescriptors of proteomics maps: background and applications.
This article reviews recent developments in the formulation and application of biodescriptors to characterize proteomics maps. Such biodescriptors can be derived by applying techniques from discrete mathematics (graph theory, linear algebra and information theory). This review focuses on the development of biodescriptors for proteomics maps derived from 2D gel electrophoresis. Preliminary results demonstrated that such descriptors have a reasonable ability to differentiate between proteomics patterns that result from exposure to closely related individual chemicals and complex mixtures, such as the jet fuel JP-8. Further research is required to evaluate the utility of these proteomics-based biodescriptors for drug discovery and predictive toxicology.
Basak
Subhash C
SC
Center for Water and the Environment, Natural Resources Research Institute, Duluth, MN 55811, USA. sbasak@nrri.umn.edu
Gute
Brian D
BD
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D019295:Computational Biology; D003196:Computer Graphics; D015195:Drug Design; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D006838:Hydrocarbons / Q000633:toxicity; D007257:Information Theory; D015603:Keratinocytes / Q000737:chemistry / Q000187:drug effects; D011506:Proteins / Q000032:analysis*; D040901:Proteomics; D013678:Technology, Pharmaceutical / Q000379:methods*
D015415:Biomarkers; D006838:Hydrocarbons; C098607:JP8 aviation fuel; D011506:Proteins