title: [Sensitivity to antibiotics of Escherichia coli strains isolated from children admitted to the "Sf. Ioan" clinical emergency hospital for children in Galaţi during 2005-2006].
abstract: The urinary tract infections (UTI) in children represent an important problem both because of their frequency, particularly in small children, and because of the morbidity they generate, sometimes on a long term. Escherichia coli represents the etiologic cause of 80% of these urinary infections. In 2005, 66 E. coli strains were analyzed and, in 2006, 69 E. coli strains were analyzed, coming from significantly positive urocultures > 10(5) UFC/ml. The E. coli strains were identified by the morphologic, culture and biochemical characters. The testing of the sensitivity to antibiotics was performed by the disk-diffusimetry method on Mueller-Hinton agar, and the reading was done visually, according to standards recommended by the suppliers of antibiotics disks. The results were as follows: Sensitivity to antibiotics, even though it was only tested for two years, has recorded slight decreases for some of the antibiotics (beta-lactams simple or in association with beta-lactamase inhibitors). This situation is probably due to a wrong treatment with these drugs, which made E. coli acquire the resistance characters. For cephalosporins, a decrease in the sensitivity was noticed above all for cephalosporins in generations 1 and 2, leaving those in generation 3 with an increased sensitivity. An important decrease was also recorded for the combination trimethoprim-sulfamethoxazole. Still, some urinary strains of E. coli remain sensitive to drugs such as: colistin, aminoglycosides, cephalosporins (particularly the third generation), fosfomycin, imipenem and the fluoroquinolones.
authors.affiliation: Facultatea de Medicină şi Farmacie Galaţi, Spitalul Clinic de Urgenţă pentru Copii Sf. loan Galaţi.
authors.forename: Caliopsia
authors.initials: C
authors.lastname: Florea
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015780:Carbapenems / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D004636:Emergency Service, Hospital; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D024841:Fluoroquinolones / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology; D006776:Hospitals, Pediatric; D006801:Humans; D008826:Microbial Sensitivity Tests; D011113:Polymyxins / Q000494:pharmacology; D012189:Retrospective Studies; D012383:Romania; D014295:Trimethoprim / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D024841:Fluoroquinolones; D011113:Polymyxins; D047090:beta-Lactams; D005578:Fosfomycin; D002701:Chloramphenicol; D014295:Trimethoprim; D003091:Colistin