title: Sustained remission after rituximab-containing chemotherapy for intravascular large B-cell lymphoma.
abstract: Intravascular large B-cell lymphoma (IVL) is rare aggressive disseminated lymphoma associated with poor outcomes. Rituximab is a novel molecular agent that can reportedly improve outcomes for patients with diffuse large B-cell lymphoma. However, the safety and efficacy of rituximab in patients with IVL are unclear. A 76-year-old woman was hospitalized due to altered consciousness, fever and respiratory abnormalities. Definitive diagnosis of IVL was obtained following repeated biopsies of bone marrow. The patient received chemotherapy consisting of cyclophosphamide, vincristine, doxorubicin, prednisolone, and rituximab (R-CHOP), and achieved complete remission after 3 courses of treatment. She has remained in complete remission for over 3 years after diagnosis. This report suggests that rituximab-containing regimens could be safe and effective for elderly patients with IVL.
authors.affiliation: Department of Hematology, Ogaki Municipal Hospital, Gifu, Japan. kshimada@med.nagoya-u.ac.jp
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kosugi
authors.forename: Hiroto
authors.initials: H
authors.lastname: Narimatsu
authors.forename: Satoko
authors.initials: S
authors.lastname: Shimada
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ito
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Mori
authors.forename: Tomoki
authors.initials: T
authors.lastname: Naoe
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000503:physiopathology; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone