The effects of race and age on axillary lymph node involvement in breast cancer patients at a Midwestern safety-net hospital.
BACKGROUND
Black and premenopausal patients have been shown to have poorer stage for stage survival than the overall population. The purpose of this study was to define the effects of age and race on axillary lymph node involvement at a Midwestern safety-net hospital. The hypothesis was that black patients under the age of 50 would be found to have increased rates of axillary involvement in breast cancer.


METHODS
A retrospective case review was performed of 184 breast cancer patients from 2000 to 2005. Statistical analysis was performed by race and age. Patients under 50 years of age were defined as premenopausal.


RESULTS
The overall rate of axillary involvement was 47.8%. Black patients had an overall rate of axillary involvement of 52.9%. However, premenopausal black patients had a 70.8% rate of axillary involvement (P < .05). Premenopausal white patients had a 46.3% rate of axillary involvement. Logistic regression analysis was performed, and premenopausal age and tumor size were found to be independent predictors of positive lymph node status in black patients.


CONCLUSIONS
In our study, premenopausal black patients had a much higher rate of axillary lymph node involvement than any other group. This finding was consistent even when tumor size was taken into account. More research needs to be done to better define this difference and to detect this disease at an earlier stage.
Kenney
Robert J
RJ
Department of Surgery, Truman Medical Center, University of Missouri-Kansas City, Kansas City, MO, USA.
Marszalek
Jacob M
JM
McNally
Megan E
ME
Nelson
Brook V
BV
Herati
Amin S
AS
Talboy
Glenn E
GE
D001741:Black or African American; D000367:Age Factors; D001365:Axilla; D001943:Breast Neoplasms / Q000208:ethnology* / Q000473:pathology*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015146:Midwestern United States; D008923:Missouri; D017697:Premenopause; D012189:Retrospective Studies; D044465:White People