[Tissue distribution on methyl nonyl ketone of the volatile oil from Houttyunia cordata in mice].
OBJECTIVE
To study the tissue distribution on methyl nonyl ketone of the volatile oil from Houttuynia cordata in mice in order to provide a guidance for the clinical trial.


METHODS
The concentrations of the volatile oil from Houttuynia cordata in biological samples were determined by GC method.


RESULTS
After a single oral dose of 5.0 g/kg volatile oil from Houttuynia cordata in mice, parent drug was mainly distributed in windpipe, intesting, liver, kidney, heart, blood, spleen, lung, brain, muscle; after 7 hours, parent drug of every tissue decreased over 90%.


CONCLUSIONS
Parent drug mianly distributes in windpipe, intestine, liver, kidney. The experiment provides pharmacokinetic evidence for the rational administration and the further development of Houttuynia cordata.
Xiao
Xue-feng
XF
Tianjin University of TCM, Tianjin 300193, China. kai1219@163.com
Gao
Lan
L
Sun
Yu
Y
Zhang
Jun-ping
JP
Qiao
Xiao-li
XL
Han
Ya-peng
YP
D000284:Administration, Oral; D000818:Animals; D002849:Chromatography, Gas; D004947:Esophagus / Q000378:metabolism*; D005260:Female; D052859:Houttuynia / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000378:metabolism; D007659:Ketones / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D014018:Tissue Distribution
D007659:Ketones; D009822:Oils, Volatile; C526928:undecan-2-one