title: [Surgical therapy in Menière's disease. Historical development and today's state of the art].
abstract: After P. Menière's first description of the typical symptoms in 1861 it took more than 40 years before the first otosurgical procedures were performed to cure Menière's disease. Various surgical methods were established during the twentieth century, which still are employed in the treatment of intractable Menière's disease, especially saccotomy and vestibular neurectomy but also intoxication of the labyrinth by intratympanic application of gentamicin. Despite the good results of such therapeutic regimens the basic pathological mechanism is still not fully understood. Since the description of an endolymphatic hydrops by Hallpike und Cairns in 1938 as a typical feature, there have been some observations of a possible infectious, allergic and autoimmunological (co)pathogenesis without enough proof to explain the disease in every case. This article aims to present the current scientific data, diagnostics and therapy of Menière's disease with special emphasis on surgical treatment options.
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf-, Hals- und plastische Gesichtschirurgie, Klinikum Darmstadt, Heidelberger Landstrasse 379, 64297 Darmstadt - Eberstadt. Gerald.Baier@klinikum-darmstadt.de
authors.forename: G
authors.initials: G
authors.lastname: Baier
authors.forename: I
authors.initials: I
authors.lastname: Ott
mesh_terms: D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D038622:Internationality; D008575:Meniere Disease / Q000175:diagnosis* / Q000266:history / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000266:history / Q000379:methods* / Q000639:trends*