title: Polysaccharide storage myopathy in Cob Normand draft horses.
abstract: Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 +/- 21.4 microm) compared with normal ones (57.3 +/- 19.7 microm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Re-biopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.
authors.affiliation: Institut National de la Recherche Agronomique, UMR 703, Ecole Nationale Veterinaire, Nantes, France.
authors.forename: T
authors.initials: T
authors.lastname: Larcher
authors.forename: B
authors.initials: B
authors.lastname: Herszberg
authors.forename: S
authors.initials: S
authors.lastname: Molon-Noblot
authors.forename: L
authors.initials: L
authors.lastname: Guigand
authors.forename: S
authors.initials: S
authors.lastname: Chaffaux
authors.forename: G
authors.initials: G
authors.lastname: Guerin
authors.forename: Y
authors.initials: Y
authors.lastname: Cherel
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D006008:Glycogen Storage Disease / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D006651:Histocytochemistry / Q000662:veterinary; D006734:Horse Diseases / Q000378:metabolism* / Q000473:pathology; D006736:Horses; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000648:ultrastructure; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011134:Polysaccharides / Q000378:metabolism*
chemical_list: D011134:Polysaccharides