HIV-1 infected Germans have more variations on neck region of DC-specific intercellular adhesion molecule-3-grabbing nonintegrin than HIV-1 infected Chinese.
The C-type lectins DC-SIGN and DC-SIGNR bind and transmit HIV-1 depending on the tetramer formed by "neck" region and carbohydrate recognition domain (CRD). Recent studies indicated polymorphisms in neck region of DC-SIGNR were more frequent and associated with susceptibility to HIV-1 infection, whereas no similar trends were observed on DC-SIGN for rare variations of DC-SIGN among the researched subjects in those studies. In our present study, we found 9 genotype variations of DC-SIGN neck region among HIV infected Germans and 3 variations among HIV infected Chinese, respectively. Comparison of those variations between Chinese and Germans reveals strong ethnic discrepancies, and no significant evidence indicates those variations have resistance to susceptibility to HIV-1 infection.
Li-Jun
X
X
Institute of Infectious Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang Province, China.
Brockmeyer
N H
NH
Bader
A
A
Hang-Ping
Y
Y
Zhi-Gang
W
W
Nanping
Wu
W
D015815:Cell Adhesion Molecules / Q000235:genetics*; D002681:China / Q000453:epidemiology; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D015497:HIV-1; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D017931:DNA Primers; D037181:Lectins, C-Type; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin