title: Pulmonary vein isolation using segmental versus electroanatomical circumferential ablation for paroxysmal atrial fibrillation: over 3-year results of a prospective randomized study.
abstract: OBJECTIVE
  We tested the hypothesis that electroanatomic pulmonary vein (PV) antra encircling for the PV isolation will improve the outcome in treatment of paroxysmal atrial fibrillation (PAF), compared with segmental PV isolation.
  
  
  METHODS
  Fifty-four patients underwent segmental PV isolation (group 1) and 56 patients circumferential PV isolation (group 2) for symptomatic PAF in a randomized study.
  
  
  RESULTS
  Following single ablation procedure, at the 48 +/- 8 month follow-up, 30 (56%) and 32 (57%) patients in groups 1 and 2 remained free of arrhythmia (P = 0.41). After repeat ablation, 43 (80%) and 45 (80%) patients in groups 1 and 2 were free of arrhythmia without antiarrhythmic drugs (AADs); 48 (89%) and 51 (91%) patients in groups 1 and 2 did not have arrhythmia recurrences without or with AADs.
  
  
  CONCLUSIONS
  This study demonstrates no advantage in long-term arrhythmia-free clinical outcome after circumferential PV isolation in patients with frequent PAF.
authors.affiliation: Department of Cardiology, Heart Center, Hospital Podlesí, a.s., Konská 453, Trinec 739 61, Czech Republic. martin.fiala@nempodlesi.cz
authors.forename: Martin
authors.initials: M
authors.lastname: Fiala
authors.forename: Jan
authors.initials: J
authors.lastname: Chovancík
authors.forename: Renáta
authors.initials: R
authors.lastname: Nevralová
authors.forename: Radek
authors.initials: R
authors.lastname: Neuwirth
authors.forename: Otakar
authors.initials: O
authors.lastname: Jiravský
authors.forename: Igor
authors.initials: I
authors.lastname: Nykl
authors.forename: Libor
authors.initials: L
authors.lastname: Sknouril
authors.forename: Miloslav
authors.initials: M
authors.lastname: Dorda
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Januska
authors.forename: Marian
authors.initials: M
authors.lastname: Branny
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000601:surgery*; D012008:Recurrence; D019233:Retreatment