title: A convenient stereochemical notation for p-chiral nucleotide analogs.
abstract: The D(P)/L(P) convention is a stereochemical notation for P-chiral nucleotide analogs and related compounds. In contrast to the absolute R(P)/S(P) notation, the D(P)/L(P) system is based on a geometrical relationship between substituents in a dinucleoside monophosphate skeleton. The D(P)/L(P) notation is a convenient alternative to the R(P)/S(P) notation for stereochemical correlation analysis of physical, chemical, and biological properties of nucleotide and oligonucleotide analogs bearing any type of tri- or tetra-coordinated phosphorus moiety.
authors.affiliation: Institute of Bioorganic Chemistry, Poznan, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Sobkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Stawinski
authors.forename: Adam
authors.initials: A
authors.lastname: Kraszewski
mesh_terms: D008024:Ligands; D009711:Nucleotides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D009711:Nucleotides