Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma.
OBJECTIVE
To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC).


METHODS
A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage II and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT.


RESULTS
The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, alpha-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m > or = 20% than in those with TRR1m < 20% (P < 0.001).


CONCLUSIONS
RT is effective in treating advanced HCC with a tumor response rate of 56.9%.
Seo
Yeon Seok
YS
Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Sungbuk-gu, Seoul 136-705, Korea. umsh@korea.ac.kr.
Kim
Jin Nam
JN
Keum
Bora
B
Park
Sanghoon
S
Kwon
Yong Dae
YD
Kim
Yong Sik
YS
Jeen
Yoon Tae
YT
Chun
Hoon Jai
HJ
Kim
Chul Yong
CY
Kim
Chang Duck
CD
Ryu
Ho Sang
HS
Um
Soon Ho
SH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011878:Radiotherapy / Q000009:adverse effects; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000032:analysis
C097353:AFP protein, human; D000509:alpha-Fetoproteins