title: Relationship between global end-diastolic volume and cardiac output in critically ill infants and children.
abstract: OBJECTIVE
  The objective of this study was to investigate possible correlations between the preload index global end-diastolic volume (GEDV) and the indexes of cardiac function, cardiac index, and stroke volume index in critically ill pediatric patients. The aim was to evaluate whether GEDV may help in the decision-making process concerning volume loading.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Pediatric intensive care unit of the Bambino Gesù Children's Research Hospital.
  
  
  METHODS
  Seventy patients, 40 male and 30 female, mean age 62 +/- 41 months (range 5-156 months), divided into six groups: group A, hemorrhagic shock, ten cases; group B, head injury, 21 cases; group C, septic shock, ten cases; group D, encephalitis, ten cases; group E, respiratory failure, nine cases; group F, cardiogenic shock, ten cases.
  
  
  METHODS
  All patients received volumetric hemodynamic monitoring following initial resuscitation and every 4 hrs thereafter or whenever a hemodynamic deterioration was suspected. During the cumulative in-hospital stay, a total 1,184 sets of measurements were done.
  
  
  RESULTS
  Findings are consistent with a statistically significant linear correlation of GEDV with cardiac index and stroke volume index in hemorrhagic shock (group A) (R2 = .647, p < .0001; R2 = .738, p < .0001) and cardiogenic shock (group F) (R2 = .645, p < .0001; R2 = .841, p < .0001).
  
  
  CONCLUSIONS
  GEDV may potentially be a useful guide to treatment in preload-dependent conditions, such as hemorrhagic and cardiogenic shock. In the other groups where there is little relationship between preload and cardiac function indexes, the influence of non-preload-dependent mechanisms on cardiac output is certainly more significant.
authors.affiliation: Terapia Intensiva Pediatrica, Dipartimento di Emergenza ed Accettazione, IRCS Bambino Gesù, Piazzale S Onofrio 5, Roma, Italia.
authors.forename: Corrado
authors.initials: C
authors.lastname: Cecchetti
authors.forename: Riccardo
authors.initials: R
authors.lastname: Lubrano
authors.forename: Sebastian
authors.initials: S
authors.lastname: Cristaldi
authors.forename: Francesca
authors.initials: F
authors.lastname: Stoppa
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Barbieri
authors.forename: Marco
authors.initials: M
authors.lastname: Elli
authors.forename: Raffaele
authors.initials: R
authors.lastname: Masciangelo
authors.forename: Daniela
authors.initials: D
authors.lastname: Perrotta
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Travasso
authors.forename: Claudia
authors.initials: C
authors.lastname: Raggi
authors.forename: Marco
authors.initials: M
authors.lastname: Marano
authors.forename: Nicola
authors.initials: N
authors.lastname: Pirozzi
mesh_terms: D000293:Adolescent; D002302:Cardiac Output; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D013318:Stroke Volume