Nephrectomy modifies renal angiotensin II effects in kidney donors.
BACKGROUND
Age, gender, menopausal status, a family history of hypertension, and renal vascular response to angiotensin II are involved in the progression of renal failure from its very beginning.


METHODS
In order to investigate their importance on this progression, we measured effective renal plasma flow (ERPF) and glomerular filtration rate (GFR), and calculated glomerular pressure (Pglo) and afferent and efferent arteriole resistances (by means of Gomez formulae) in 26 normotensive kidney donors before and after nephrectomy.


RESULTS
Renal reactivity to angiotensin was the only variable that affected changes in renal and glomerular hemodynamics after the loss of renal tissue: in subjects with greater angiotensin reactivity, higher afferent resistances (Ra) and lower glomerular filtration and pressure before nephrectomy change to higher efferent resistances (Re) and higher Pglo and filtration after nephrectomy.


CONCLUSIONS
In normotensive donors with a normal compensatory response to nephrectomy, baseline renal reactivity to angiotensin II can influence renal and glomerular hemodynamics 1 year after nephrectomy.
Guidi
Ettore
E
Centro di Ricerca Clinica in Nefrologia e Ipertensione Arteriosa, Dipartimento Cardiologico, Ospedale Niguarda Ca'Granda, Milan, Italy. ettore.guidi@fastwebnet.it
Cozzi
Mariagrazia
M
Milani
Silvano
S
Spada
Elena
E
D000222:Adaptation, Physiological; D000328:Adult; D000802:Angiotensin Amide / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D002417:Cattle; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D006801:Humans; D007263:Infusions, Parenteral; D007668:Kidney / Q000098:blood supply / Q000378:metabolism / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009392:Nephrectomy; D012079:Renal Circulation; D051437:Renal Insufficiency / Q000378:metabolism / Q000503:physiopathology; D013997:Time Factors; D014655:Vascular Resistance
D000802:Angiotensin Amide