title: Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis.
abstract: In search of reducing vaccine production costs', a recombinant M13 phage version of the anti-cysticercosis tripeptide vaccine (S3Pvac) was developed. The efficacy of S3Pvac-Phage vs. placebo was evaluated in a randomized trial that included 1,047 rural pigs in 16 villages of Central Mexico. Three to five months after vaccination 530 pigs were examined by tongue inspection. At 5-27 months of age, 331 pigs (197 vaccinated/134 controls) were inspected at necropsy. Vaccination reduced 70% the frequency of tongue cysticercosis and, based on necropsy, 54% of muscle-cysticercosis and by 87% the number of cysticerci.
authors.affiliation: Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico.
authors.forename: Julio
authors.initials: J
authors.lastname: Morales
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Martínez
authors.forename: Karen
authors.initials: K
authors.lastname: Manoutcharian
authors.forename: Marisela
authors.initials: M
authors.lastname: Hernández
authors.forename: Agnes
authors.initials: A
authors.lastname: Fleury
authors.forename: Goar
authors.initials: G
authors.lastname: Gevorkian
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Acero
authors.forename: Abel
authors.initials: A
authors.lastname: Blancas
authors.forename: Andrea
authors.initials: A
authors.lastname: Toledo
authors.forename: Jacquelynne
authors.initials: J
authors.lastname: Cervantes
authors.forename: Victor
authors.initials: V
authors.lastname: Maza
authors.forename: Fabrice
authors.initials: F
authors.lastname: Quet
authors.forename: Henri
authors.initials: H
authors.lastname: Bonnabau
authors.forename: Aline S
authors.initials: AS
authors.lastname: de Aluja
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Carlos
authors.initials: C
authors.lastname: Larralde
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D000947:Antigens, Helminth / Q000096:biosynthesis / Q000276:immunology*; D017104:Bacteriophage M13 / Q000276:immunology* / Q000378:metabolism; D003551:Cysticercosis / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary*; D008800:Mexico; D012424:Rural Population; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D014612:Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D015164:Vaccines, Inactivated / Q000276:immunology; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000947:Antigens, Helminth; D014612:Vaccines; D015164:Vaccines, Inactivated