Effects of metabolic risk factors on production of plasminogen activator inhibitor-1 and adiponectin by adipocytes.
BACKGROUND
Type 1 plasminogen activator inhibitor (PAI-1) and adiponectin are produced by adipocytes and are important in the progression of coronary artery disease (CAD).


RESULTS
Different concentrations of glucose, insulin and 1% triglycerides were used to assay PAI-1 and adiponectin production from cultured adipocytes. Triglycerides induced the highest PAI-1 production with 16.5 mmol/L glucose and 50 nmol/L insulin. In contrast, glucose and insulin decreased adiponectin production in a dose-dependent manner irrespective of triglycerides.


CONCLUSIONS
The metabolic syndrome risk factors alter PAI-1 and adiponectin production by adipocytes, in the presence or absence of triglycerides, which might play a role in the development of CAD.
Sakamoto
Kenji
K
Division of Cardiology, Health Insurance Yatsushiro General Hospital, Yatsushiro, Japan.
Sakamoto
Tomohiro
T
Ogawa
Hisao
H
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism*; D051379:Mice; D012307:Risk Factors; D058258:Serpin E2; D015843:Serpins / Q000378:metabolism*; D014280:Triglycerides / Q000494:pharmacology
D052242:Adiponectin; C499919:Adipoq protein, mouse; D007004:Hypoglycemic Agents; D007328:Insulin; D058258:Serpin E2; C511869:Serpine2 protein, mouse; D015843:Serpins; D014280:Triglycerides; D005947:Glucose