Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease.
BACKGROUND
Ollier Disease is a sporadic skeletal disorder with a predisposition to oncogenesis. It is estimated at around 1/100,000. We are presenting a young patient with Ollier Disease and high-grade astrocytoma.


METHODS
A 14-year-old, Caucasian male with Ollier Disease presented with a history of headaches, vomiting, blurred vision, and unsteady gait. Brain MRI with contrast showed a 41 x 55 mm mass in the posterior fossa with spotty enhancement, which pathology proved to be anaplastic astrocytoma.


CONCLUSIONS
Despite the universal acceptance that Ollier Disease carries a high risk of developing malignancy there is very little in the literature about systematic screening. We recommended a cost-effective screening regime for these patients.
Walid
Mohammad Sami
MS
Medical Center of Central Georgia, 840 Pine Street, Macon, GA 31201, USA. mswalid@yahoo.com
Troup
Earl Christopher
EC
D000293:Adolescent; D000367:Age Factors; D001254:Astrocytoma / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D002812:Chondroma / Q000000981:diagnostic imaging / Q000473:pathology; D004687:Enchondromatosis / Q000150:complications*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006261:Headache / Q000209:etiology; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009154:Mutation / Q000235:genetics; D019635:Neurosurgical Procedures; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D011859:Radiography; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000235:genetics / Q000378:metabolism; D012540:Scapula / Q000000981:diagnostic imaging / Q000473:pathology; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology
C473449:PTH1R protein, human; D044168:Receptor, Parathyroid Hormone, Type 1; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human