[Effect of Yishen Tiaojing Recipe on hypogonadism induced by Tripterygium glycosides in women patients with nephropathy].
OBJECTIVE
To explore the effect of Yishen Tiaojing Recipe (YSTJR) on sex gland and kidney in nephropathy patients with hypogonadism induced by Tripterygium glycosides (TG).


METHODS
Fifty-eight women patients with chronic glomerular disease were assigned to two groups, the 34 patients in the treated group were given TP 20 mg three times a day plus YSTJR, one dose daily, while the 24 in the control group were given TP 20 mg three times a day alone. The course of treatment lasted for 3 months. Serum levels of estradiol (E2), follicle-stimulating hormone (FSH), and luteotrophic hormone (LH), as well as urinary protein and red blood cell (RBC) count in urine were determined before and after treatment.


RESULTS
Level of E2 decreased, FSH and LH increased in the control group after treatment (P < 0.05), while those indexes unchanged in the treated group. Quantity of urinary protein decreased in both two groups after treatment (P < 0.05), but the decrement was more significant in the treated group than in the control group (P < 0.05). Differences of all the above-mentioned indexes between the two groups after treatment were significant (all P < 0.05).


CONCLUSIONS
YSTJR could prevent the injury of TP on sex gland in women patients with nephropathy, and is benificial for the treatment of primary chronic renal glomerular diseases.
Mao
Li-Ming
LM
Department of Nephrology, Hangzhou Hospital of TCM, Hangzhou. limingmao@sina.com
Cheng
Xiao-Xia
XX
Xu
Yin-Yu
YY
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005921:Glomerulonephritis / Q000188:drug therapy*; D006027:Glycosides / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008875:Middle Aged; D008517:Phytotherapy; D016896:Treatment Outcome; D029757:Tripterygium / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D006027:Glycosides; C532897:yishen tiaojing; D004958:Estradiol; D005640:Follicle Stimulating Hormone