Nickel-catalyzed decarbonylative addition of phthalimides to alkynes.
An intermolecular nickel-catalyzed addition reaction has been developed where N-arylphthalimides react with alkynes to afford substituted isoquinolones. A mechanistic rationale is proposed, implying nucleophilic attack of Ni(0) to an amide as the primary step of the catalytic cycle.
Kajita
Yuichi
Y
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Matsubara
Seijiro
S
Kurahashi
Takuya
T