title: Ziprasidone-induced tardive laryngeal dystonia: a case report.
abstract: Tardive laryngeal dystonia, a rare form of dystonic syndrome, was only reported to be induced by typical antipsychotics. Here, we report one case of ziprasidone-induced tardive laryngeal dystonia in a schizophrenic female patient, who showed dysphonia, hoarseness and dyspnea after taking ziprasidone 120 mg/day for 8 months. These symptoms were significantly improved after discontinuing ziprasidone and increasing the dose of trihexyphenidyl for 1 week. Although atypical antipsychotics are associated with a lower risk of extrapyramidal symptoms, caution should be taken for any tardive dystonic movement when using these medications.
authors.affiliation: Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung County, Taiwan.
authors.forename: Ching-Shu
authors.initials: CS
authors.lastname: Tsai
authors.forename: Yu
authors.initials: Y
authors.lastname: Lee
authors.forename: Yung-Yee
authors.initials: YY
authors.lastname: Chang
authors.forename: Pao-Yen
authors.initials: PY
authors.lastname: Lin
mesh_terms: D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004417:Dyspnea / Q000139:chemically induced / Q000175:diagnosis; D004421:Dystonia / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006685:Hoarseness / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D007818:Laryngeal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use; D014282:Trihexyphenidyl / Q000627:therapeutic use; D014832:Voice Disorders / Q000139:chemically induced / Q000175:diagnosis
chemical_list: D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; D014282:Trihexyphenidyl; C092292:ziprasidone