title: STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians.
abstract: The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N=274) and SLE (N=144) and matched healthy controls (N=421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P=0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P=0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.
authors.affiliation: Instituto de Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
authors.forename: R J
authors.initials: RJ
authors.lastname: Palomino-Morales
authors.forename: A
authors.initials: A
authors.lastname: Rojas-Villarraga
authors.forename: C I
authors.initials: CI
authors.lastname: González
authors.forename: G
authors.initials: G
authors.lastname: Ramírez
authors.forename: J-M
authors.initials: JM
authors.lastname: Anaya
authors.forename: J
authors.initials: J
authors.lastname: Martín
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D003105:Colombia; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D050797:STAT4 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D047990:TNF Receptor-Associated Factor 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D050797:STAT4 Transcription Factor; D047990:TNF Receptor-Associated Factor 1