title: Contact dermatitis from a prosthesis.
abstract: Patients wearing a prosthesis face a wide variety of medical problems. Skin complications have long been recognized, but their prevalence is still unknown. The most frequently reported disorders are allergic contact dermatitis (ACD), acroangiodermatitis, epidermoid cysts, epidermal hyperplasia, follicular hyperkeratosis, verrucous hyperplasia, bullous diseases, hyperhidrosis, infections, malignancies, and ulcerations. Contact dermatitis represents one-third of the dermatoses in amputees wearing prostheses. All patients who are suspected of having ACD should be patch tested with standard allergen series as well as materials from the patient's own prosthesis, topical medicaments, moisturizers, and cosmetics. We report a patient with an ACD to mixed dialkyl thiourea present in the rubber parts of his below-the-knee prosthesis. Thiourea derivates are used as accelerators in the manufacture of chloroprene rubber and as fixatives in photography and photocopy paper. Allergy to thiourea is relatively uncommon; different studies have shown a prevalence of 0.7% up to 2.4% in patch-tested patients. Thiourea derivates are often the allergic sources in ACD involving high-grade rubber products made of neoprene such as diving suits, protective goggles, knee braces, and continuous positive airway pressure masks. They are also present in the rubber material of prostheses, as in the case of our patient.
authors.affiliation: Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Carla A
authors.initials: CA
authors.lastname: Munoz
authors.forename: Anthony
authors.initials: A
authors.lastname: Gaspari
authors.forename: Ronald
authors.initials: R
authors.lastname: Goldner
mesh_terms: D000674:Amputees; D001186:Artificial Limbs / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009387:Neoprene / Q000009:adverse effects*; D010328:Patch Tests; D012307:Risk Factors; D012867:Skin / Q000473:pathology; D013890:Thiourea / Q000009:adverse effects*
chemical_list: D009387:Neoprene; D013890:Thiourea