title: TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.
abstract: Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI. We have evaluated the possible association between two polymorphisms of TLR2 gene-Arg677Trp and Arg753Gln-and MI. However, we found no association between TLR2 polymorphisms and MI.
authors.affiliation: Gruppo di studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Italy. crbalistreri@unipa.it
authors.forename: Carmela Rita
authors.initials: CR
authors.lastname: Balistreri
authors.forename: Guiseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Monica
authors.initials: M
authors.lastname: Mirabile
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
authors.forename: Egle
authors.initials: E
authors.lastname: Incalcaterra
authors.forename: Marco
authors.initials: M
authors.lastname: Caruso
authors.forename: Enrico
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics*; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007558:Italy; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*
chemical_list: D051195:Toll-Like Receptor 2