title: Acquired progressive spastic paraparesis due to neurobrucellosis: a case report.
abstract: A 39-year-old man with a 4-month history of transient pins and needles sensations occurring below the waist while walking and difficulty walking presented to our outpatient clinic. He had an approximate 1-year history of bilateral hearing loss, the etiology of which was unknown. His symptoms had been progressive, and there was no significant family history. He demonstrated a spastic gait and required assistance for walking. Deep tendon reflexes were hypertonic; a sensation deficit was defined as originating from the 12th thoracic vertebra. Babinski's sign was positive bilaterally. Sphincter abnormalities were seen in the patient's bladder and bowel functions. Cerebral and spinal magnetic resonance images with contrast media were unremarkable. An analysis of the patient's cerebrospinal fluid was consistent with neurobrucellosis. Owing to spastic paraparesis and hearing loss, the diagnosis of neurobrucellosis was made. Combined antimicrobial therapy was started and continued 6 months. His neurologic condition improved, and he was able to walk without help after 3 months' treatment. Our case illustrates that acquired progressive spastic paraparesis may occur during the course of neurobrucellosis. Neurobrucellosis should be borne in mind when patients present with spastic paraparesis.
authors.affiliation: Department of Neurology, Faculty of Medicine, Baskent University, Medical School, Ankara, Turkey. sibelemre2003@yahoo.com
authors.forename: Sibel
authors.initials: S
authors.lastname: Karaca
authors.forename: Yusuf Ziya
authors.initials: YZ
authors.lastname: Demiroglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karataş
authors.forename: Meliha
authors.initials: M
authors.lastname: Tan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002006:Brucellosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000503:physiopathology*; D002443:Ceftriaxone / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D034381:Hearing Loss / Q000382:microbiology; D006801:Humans; D008297:Male; D020336:Paraparesis, Spastic / Q000134:cerebrospinal fluid / Q000382:microbiology* / Q000503:physiopathology*; D012293:Rifampin / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D004318:Doxycycline; D012293:Rifampin