title: Mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men: a case series and review of the literature.
abstract: Melasma is a common hyperpigmentation disorder that typically affects women, though up to 10% of white individuals seeking treatment for melasma are men. Melasma can be a source of embarrassment for men because of its association with women and pregnancy. We performed a case series assessing the use of mequinol 2%/ tretinoin 0.01% topical solution in 5 men with melasma. Four of 5 patients achieved complete clearance of melasma at 12 weeks, and 1 patient showed moderate improvement. Side effects were minimal and consisted of stinging in one patient. All patients maintained results at the 16-week follow-up visit. Mequinol 2%/tretinoin 0.01% topical solution was an effective and well-tolerated treatment of melasma in men. The vehicle resulted in good compliance and minimal adverse effects in patients. This is the first report describing the use of mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men; there are no reports in women.
authors.affiliation: Wellington Regional Medical Center, Florida, USA. drjonkeeling@yahoo.com
authors.forename: Jon
authors.initials: J
authors.lastname: Keeling
authors.forename: Lina
authors.initials: L
authors.lastname: Cardona
authors.forename: Adolpho
authors.initials: A
authors.lastname: Benitez
authors.forename: Rachel
authors.initials: R
authors.lastname: Epstein
authors.forename: Marta
authors.initials: M
authors.lastname: Rendon
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000840:Anisoles / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy*; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D008548:Melanosis / Q000188:drug therapy*; D008875:Middle Aged; D012996:Solutions; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D000840:Anisoles; D000975:Antioxidants; D007641:Keratolytic Agents; D012996:Solutions; D014212:Tretinoin; C009760:mequinol