[Study of lactate dehydrogenase isoenzyme in the cerebrospinal fluid of patients with acute lymphoblastic leukemia].
Lactate dehydrogenase isoenzymes were profiled in cerebrospinal fluid in patients with acute lymphoblastic leukemia. Cytological examination of patients with central nervous involvement identified isoenzyme 5 which failed to show after selective treatment. The isoenzyme's detection in cerebrospinal fluid without typical cytological characteristics may be regarded as a precursor of such complication. Hence, this may be used as an additional criterion for refinement of cytological evidence employed in diagnosis and prognosis of central nervous involvement in patients with acute lymphoblastic leukemia.
Lesnichenko
I F
IF
Gubarenko
N K
NK
Gritsaev
S V
SV
Salmykova
N B
NB
Blinov
M N
MN
D000328:Adult; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000134:cerebrospinal fluid; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D000080864:Lactate Dehydrogenase 5; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000201:enzymology* / Q000473:pathology; D011379:Prognosis
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5