Ruthenium-catalyzed synthesis of allylic alcohols: boronic acid as a hydroxide source.
Secondary allylic alcohols were synthesized from linear allylic halides or carbonates using a catalytic amount of a ruthenium complex in the presence of boronic acid. The effects of solvent, base, ruthenium precursor, and boronic acid were fully explored, and the scope of the reaction was extended to various substrates. We also describe a preliminary investigation towards an enantioselective process.
Bouziane
Asmae
A
Sciences Chimiques de Rennes, Ingéniérie chimique et molécules pour le vivant UMR 6226: CNRS-Université de Rennes 1, Campus de Beaulieu-35042 Rennes Cedex, France.
Hélou
Marion
M
Carboni
Bertrand
B
Carreaux
François
F
Demerseman
Bernard
B
Bruneau
Christian
C
Renaud
Jean-Luc
JL