title: Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata.
abstract: High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC 50 values of 23 and 19 microM, respectively.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland, Australia.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Sylvia
authors.initials: S
authors.lastname: Urban
authors.forename: Jasmine
authors.initials: J
authors.lastname: Lamb
authors.forename: Roger
authors.initials: R
authors.lastname: Moni
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Guymer
authors.forename: Paul I
authors.initials: PI
authors.lastname: Forster
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D035264:Flowers / Q000737:chemistry; D027822:Myrtaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011793:Queensland; D051381:Rats; D018025:Receptors, Thyrotropin-Releasing Hormone / Q000819:agonists*
chemical_list: D018025:Receptors, Thyrotropin-Releasing Hormone; C530183:corymbone A; C530184:corymbone B; D010696:Phloroglucinol