The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes.
We determined the IL-6 -174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 -174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.
Saumoy
Maria
M
Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain.
López-Dupla
Miguel
M
Veloso
Sergi
S
Alonso-Villaverde
Carlos
C
Domingo
Pere
P
Broch
Montserrat
M
Miranda
Merce
M
Coll
Blai
B
Saurí
Amadeu
A
Vendrell
Joan
J
Richart
Cristóbal
C
Vidal
Francesc
F
D000328:Adult; D000483:Alleles; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000032:analysis; D050151:Subcutaneous Fat / Q000276:immunology
D019380:Anti-HIV Agents; D015850:Interleukin-6; D012333:RNA, Messenger