title: Invivo studies on evaluation of potential toxicity of unspent tannins using albino rats (Rattusnorvegicus).
abstract: The present study emphasizes the effect of unspent tannins on liver, kidney and heart of albino rats. Oral administration of unspent tannins at three different concentrations was made for a period of seven days. Carbon tetrachloride served as positive control. Tissues were removed carefully followed by sacrifice and were subjected to sectioning and H&E staining. Histopathological examination of the sections showed, major tissue damage with the highest concentration of tannins (1500mg/kg body weight) irrespective of their nature and source, followed by moderate damage with the 1000mg/kgbw and zero damage with 500mg/kgbw. However, complete damage was observed with the tissues of positive control group. Lipid peroxidase assay using post-mitochondrial supernatant of liver, kidney and heart showed appreciable levels of malondialdehyde release at higher concentrations of tannins.
authors.affiliation: Microbiology Division, Central Leather Research Institute, Adyar, Chennai 20, Tamil Nadu, India.
authors.forename: Munuswamy
authors.initials: M
authors.lastname: Sudha
authors.forename: A
authors.initials: A
authors.lastname: Gnanamani
authors.forename: G
authors.initials: G
authors.lastname: Deepa
authors.forename: M
authors.initials: M
authors.lastname: Sudha
authors.forename: E
authors.initials: E
authors.lastname: Madhavacharyulu
authors.forename: K
authors.initials: K
authors.lastname: Deivanai
authors.forename: S
authors.initials: S
authors.lastname: Sadulla
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000737:chemistry / Q000633:toxicity*; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
chemical_list: D011506:Proteins; D013634:Tannins; D014874:Water Pollutants, Chemical; D008315:Malondialdehyde