title: Synthesis of exemestane labelled with (13)C.
abstract: The synthesis of exemestane Aromasin, an irreversible steroidal aromatase inhibitor, specifically labelled with (13)C is reported. The preparation of [(13)C(3)]exemestane was achieved according to an eight-step procedure starting from the commercially available testosterone.
authors.affiliation: Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano (MI), Italy. erminia.fontana@nervianoms.com
authors.forename: Erminia
authors.initials: E
authors.lastname: Fontana
authors.forename: Alberto
authors.initials: A
authors.lastname: Pignatti
authors.forename: Danilo
authors.initials: D
authors.lastname: Giribone
authors.forename: Enrico
authors.initials: E
authors.lastname: Di Salle
mesh_terms: D000730:Androstadienes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002247:Carbon Isotopes; D007553:Isotope Labeling / Q000379:methods*; D013739:Testosterone / Q000737:chemistry
chemical_list: D000730:Androstadienes; D002247:Carbon Isotopes; D013739:Testosterone; C056516:exemestane