[Anaemia, iron index status and acute phase proteins in malaria (Abidjan, Côte d'Ivoire)].
Clinical signs of malaria are the combined expression of several biological mechanisms. During this parasite infection, anaemia can be the consequence of several different pathogenic mechanisms. It can be an acute haemolytic anaemia due to a mechanical and immune action of the parasite or an inflammation. Besides, in Africa malaria matches with iron deficiency area. So, malarial anaemia in tropical area can be a characteristic of iron deficiency The purpose of this survey was to define the features of malarial anaemia and elucidate the link of all biological processes involved. A black population living in tropical urban areas, with fever and diagnosed Plasmodium-infection was assessed. Parasitaemia, haemoglobin, hematocrit, average corpuscular volume and average corpuscular haemoglobin were determined. For each patient, iron index status and acute phase protein were assessed with the plasmatic iron, ferritin, haptoglobin, transferrin and C-reactive protein. Regardless of gender and age, the characteristics of malarial anaemia are microcythaemia and hypochromia. Anaemia occurs as frequently as parasitaemia is high. When parasitaemia is low anaemia gets a haemolytic feature. When parasitaemia is high, anaemia gets haemolytic and inflammatory features. Anaemia occurs more often with a good iron index status.
Ahiboh
H
H
Département de biochimie, Institut Pasteur de Côte d'Ivoire, BP 490 Abidjan 01, Côte d'Ivoire. hugahibo@hotmail.comr
Oga
A S
AS
Yapi
H F
HF
Kouakou
G
G
Boua
K D
KD
Edjeme
N
N
Monnet
D
D
D000209:Acute-Phase Proteins / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000469:parasitology*; D000743:Anemia, Hemolytic / Q000469:parasitology; D000747:Anemia, Hypochromic / Q000469:parasitology; D018798:Anemia, Iron-Deficiency / Q000469:parasitology; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D007560:Cote d'Ivoire; D003430:Cross-Sectional Studies; D004909:Erythrocyte Indices; D004913:Erythrocytes, Abnormal / Q000469:parasitology; D005260:Female; D005293:Ferritins / Q000097:blood; D006242:Haptoglobins / Q000032:analysis; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood*; D008288:Malaria / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000097:blood; D014168:Transferrin / Q000032:analysis
D000209:Acute-Phase Proteins; D006242:Haptoglobins; D006454:Hemoglobins; D014168:Transferrin; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron