title: A history of coeliac disease.
abstract: Coeliac disease may have an ancient history dating back to the 1st and 2nd centuries AD. The first clear description was given by Samuel Gee in 1888. He suggested that dietary treatment might be of benefit. In the early 20th century various diets were tried, with some success, but without clear recognition of the toxic components. The doctoral thesis of Wim Dicke of 1950 established that exclusion of wheat, rye and oats from the diet led to dramatic improvement. The toxicity was shown to be a protein component, referred to as gluten. Dicke's colleagues, Weijers and Van de Kamer, showed that measurement of stool fat reflected the clinical condition. Early studies were in children but stool fat measurements documented that the condition could be recognised in adults. Histological abnormalities of the lining of the small intestine were demonstrated beyond doubt by Paulley in 1954 and techniques of per-oral biopsy described by Royer in 1955 and Shiner in 1956 afforded reliable diagnosis. Concurrence in monozygotic twins suggested a genetic component, confirmed by studies of HLA antigens. Additional, non-genetic factors seem likely. Circulating antibodies suggest an immunological mechanism of damage and provide non-invasive screening tests. Lymphoma, adenocarcinoma and ulceration of the small intestine and a range of immunological disorders are associated. A relationship with dermatitis herpetiformis was suggested by Samman in 1955 and established by Shuster and Marks in 1965 and 1968. The Coeliac Society (now Coeliac UK) was founded in 1968 and similar societies now exist across the world. They provide an extremely valuable service. Present problems include definition of the tolerated levels of gluten, whether oats are toxic for some or all coeliacs and the likelihood that the condition is relatively common and frequently without classical symptoms. Hope for the future is that more convenient methods of treatment will follow better understanding.
authors.affiliation: Thackray Museum, Leeds, UK. mlosowsky@email.com
authors.forename: M S
authors.initials: MS
authors.lastname: Losowsky
mesh_terms: D002446:Celiac Disease / Q000150:complications / Q000201:enzymology / Q000266:history* / Q000473:pathology; D003874:Dermatitis Herpetiformis / Q000209:etiology / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D007414:Intestinal Neoplasms / Q000209:etiology / Q000266:history; D007421:Intestine, Small / Q000473:pathology; D008223:Lymphoma / Q000209:etiology / Q000266:history; D011503:Transglutaminases / Q000378:metabolism; D014456:Ulcer / Q000209:etiology / Q000266:history
chemical_list: D011503:Transglutaminases