First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid.
The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6- endo-dig-cyclization of phenolic oxygens to the resulting alkynes.
Rudyanto
Marcellino
M
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Tomizawa
Yuichiro
Y
Morita
Hiroshi
H
Honda
Toshio
T
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D002366:Cassia / Q000737:chemistry; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D000470:Alkaloids; D000962:Antimalarials; D006575:Heterocyclic Compounds, 3-Ring; C524027:cassiarin A