The strong MRI relaxivity of paramagnetic nanoparticles.
We developed a method to synthesize paramagnetic nanoparticles of Gd@C82(OH)22+/-2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12x MRI relaxivity of Gd@C82(OH)22+/-2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22+/-2 nanoparticles, approximately 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.
Xing
Gengmei
G
Lab for Bio-Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing, China.
Yuan
Hui
H
He
Rui
R
Gao
Xueyun
X
Jing
Long
L
Zhao
Feng
F
Chai
Zhifang
Z
Zhao
Yuliang
Y
D005682:Gadolinium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D018625:Microscopy, Atomic Force; D053758:Nanoparticles
D005682:Gadolinium