Targeting tissue angiotensin-converting enzyme for imaging cardiopulmonary fibrosis.
Convincing clinical and experimental evidence exists that the renin-angiotensin system and its primary effector peptide, angiotensin II, are linked to the pathophysiology of interstitial fibrosis in the heart and in the lung. Tissue angiotensin-converting enzyme and locally synthesized angiotensin II exert local trophic effects, which regulate fibroblast growth and proliferation. Thus, the presence of tissue renin-angiotensin system offers an opportunity for targeted imaging, which may be valuable for understanding the pathobiology of cardiopulmonary disorders and for guiding medical therapy.
Aras
Omer
O
Department of Diagnostic Radiology, University of Maryland Hospital and School of Medicine, 22 South Greene Street, Gudelsky Building, Baltimore, MD 21201-1595, USA. oaras@umm.edu
Dilsizian
Vasken
V
D000804:Angiotensin II / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D001761:Bleomycin / Q000009:adverse effects; D002268:Carboxypeptidases / Q000378:metabolism; D053818:Chymases / Q000378:metabolism; D005355:Fibrosis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D025202:Molecular Diagnostic Techniques; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D012084:Renin-Angiotensin System
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D000804:Angiotensin II; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D053818:Chymases