title: S100B in underweight and weight-recovered patients with anorexia nervosa.
abstract: Anorexia nervosa (AN) commonly arises during adolescence, leading to interruptions of somatic and psychological development as well as to cortical atrophy and reductions of brain volume. While most brain changes shift towards normal with weight restoration, it is not certain whether they are related to the loss of brain cells, neuropil or merely due to fluid shifts. We measured S100B serum concentrations and psychometric characteristics in 34 patients with acute AN, 19 weight-recovered patients and 35 healthy control women (HCW). Plasma tryptophan and leptin levels were determined as markers for malnutrition and neuroendocrine adaptation to semi-starvation. Peripheral S100B concentrations of acute and former AN patients were not elevated and not statistically different from HCW. BMI, peripheral leptin levels and measures of psychopathology as well as executive cognitive functioning did not correlate with S100B. Plasma tryptophan was positively related to S100B. Our results are in line with our previous findings showing unaltered GFAP and NSE plasma levels in patients with acute AN. Together they do not support hypotheses comprising the degeneration of glial or neuronal cells to explain common signs of brain atrophy in patients with acute AN.
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, CVK, Augustenburger Platz 1, Berlin 13353, Germany. stefan.erlich@charite.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
authors.forename: Harriet
authors.initials: H
authors.lastname: Salbach-Andrae
authors.forename: Deike
authors.initials: D
authors.lastname: Weiss
authors.forename: Roland
authors.initials: R
authors.lastname: Burghardt
authors.forename: Klaus
authors.initials: K
authors.lastname: Goldhahn
authors.forename: Eugenia Maria
authors.initials: EM
authors.lastname: Craciun
authors.forename: Leonora
authors.initials: L
authors.lastname: Franke
authors.forename: Ralf
authors.initials: R
authors.lastname: Uebelhack
authors.forename: Burghard F
authors.initials: BF
authors.lastname: Klapp
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lehmkuhl
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000534:rehabilitation*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013851:Thinness / Q000097:blood*; D014364:Tryptophan / Q000097:blood; D015430:Weight Gain / Q000502:physiology*
chemical_list: D020738:Leptin; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D014364:Tryptophan