title: Endoscopic trans-nasal approach for biopsy of orbital tumours using image-guided neuro-navigation system.
abstract: BACKGROUND
  Histopathological diagnosis of intraorbital tumours is of crucial value for planning further therapy. The aim of the study was to explore clinical utility of image-guided endoscopy for biopsy of orbital tumours.
  
  
  METHODS
  Trans-nasal endoscopic biopsy of intraorbital mass lesions was performed in 6 patients using a neuro-navigation system (Medtronic Stealth Station Treon plus). The CT and MRI 1 mm slice images were fused by the system in order to visualise both bony and soft tissue structures. The anatomic fiducial registration protocol was used during the procedure.
  
  
  RESULTS
  All lesions were precisely localised and the biopsies could be taken from the representative part of the pathological mass. None of the patients developed aggravation of ocular symptoms after the procedure. The operative corridor as well as the size of orbital wall fenestration could be limited to a minimum. The accuracy of neuro-navigation remained high and stable during the entire procedure.
  
  
  CONCLUSIONS
  The image-guided neuro-navigation system facilitated endoscopic localisation and biopsy of intraorbital tumours and contributed to the reduction of surgical trauma during the procedure. The technique was particularly useful in small, medially located, retrobulbar tumours and in unclear situations when the structure of the lesion resembled surrounding intraorbital tissue.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Medical University of Bialystok, Bialystok, Poland. sieska@interia.pl
authors.forename: A
authors.initials: A
authors.lastname: Sieskiewicz
authors.forename: T
authors.initials: T
authors.lastname: Lyson
authors.forename: Z
authors.initials: Z
authors.lastname: Mariak
authors.forename: M
authors.initials: M
authors.lastname: Rogowski
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D004724:Endoscopy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D038361:Neuronavigation / Q000592:standards; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D025321:Surgery, Computer-Assisted; D014057:Tomography, X-Ray Computed