Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
OBJECTIVE
To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy.


METHODS
Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system.


RESULTS
PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis.


CONCLUSIONS
PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment.
Galimberti
Gloria
G
Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, via Cadore 48, 20052 Monza (MI), Italy. gloria.galimberti@unimib.it
Conti
Elisa
E
Zini
Michela
M
Piazza
Fabrizio
F
Fenaroli
Francesco
F
Isella
Valeria
V
Facheris
Maurizio
M
Perlangeli
Vittoria
V
Antolini
Laura
L
DeFilippi
Francesco
F
Ferrarese
Carlo
C
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008715:Methionine / Q000008:administration & dosage* / Q000097:blood; D012680:Sensitivity and Specificity
D006710:Homocysteine; D005492:Folic Acid; D008715:Methionine