Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions.
Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for antibacterial activity, including Gram-positive cocci and Gram-negative bacilli, and carbonic anhydrase II inhibitory activity.
Massah
Ahmad Reza
AR
Department of Chemistry, Islamic Azad University, Shahreza Branch, Shahreza 86145-311, Islamic Republic of Iran. massah@iaush.ac.ir
Adibi
Hadi
H
Khodarahmi
Reza
R
Abiri
Ramin
R
Majnooni
Mohammad Bagher
MB
Shahidi
Sherita
S
Asadi
Beheshteh
B
Mehrabi
Masomeh
M
Zolfigol
Mohammad Ali
MA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors*; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013464:Sulfuric Acids / Q000737:chemistry
D000900:Anti-Bacterial Agents; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013464:Sulfuric Acids; D012822:Silicon Dioxide; D024402:Carbonic Anhydrase II