title: [Acute interstitial nephritis of fluindione: about three cases].
abstract: Acute interstitial nephritis is a frequent cause of acute renal failure, representing about 10% of all biopsied cases. Early recognition of drug-induced acute immunoallergic interstitial nephritis prevents the development of severe chronic renal injury. The list of imputable drugs includes phenindione, a vitamin K antagonist. Fluindione which is also an indanedione derivative is another vitamin K antagonist. We report three biopsy-proved cases of fluindione related acute interstitial nephritis with recovery of renal function after drug withdrawal and prednisone therapy.
authors.affiliation: Département néphrologie-dialyse, centre hospitalier Pierre-Bérégovoy, 58033 Nevers, France. christine.beauchamp@ch-nevers.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Beauchamp
authors.forename: Ioana
authors.initials: I
authors.lastname: Enache
authors.forename: Abraham
authors.initials: A
authors.lastname: Haskour
authors.forename: Laurent
authors.initials: L
authors.lastname: Martin
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000188:drug therapy; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D010630:Phenindione / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D004232:Diuretics; D014812:Vitamin K; D010630:Phenindione; C017673:fluindione