The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma.
BACKGROUND
Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally.


METHODS
In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion of chromosomes 1p and 19q, a marker of good prognosis, could be predicted accurately by measuring image texture.


RESULTS
Differences in texture were seen between tumors with codeletion of chromosomes 1p and 19q and those with intact 1p and 19q alleles on contrast-enhanced T1-weighted and T2-weighted MR images. Quantitative MR texture on T2 images predicted codeletion of chromosomes 1p and 19q with high sensitivity and specificity.


CONCLUSIONS
This new method of MR image interpretation may have the potential to augment the diagnostic assessment of patients with suspected low-grade glioma.
Brown
Robert
R
Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada.
Zlatescu
Magdalena
M
Sijben
Angelique
A
Roldan
Gloria
G
Easaw
Jay
J
Forsyth
Peter
P
Parney
Ian
I
Sevick
Robert
R
Yan
Elizabeth
E
Demetrick
Douglas
D
Schiff
David
D
Cairncross
Gregory
G
Mitchell
Ross
R
D000328:Adult; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009837:Oligodendroglioma / Q000235:genetics*