title: Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur.
abstract: We report a new type of secondary malignant giant cell tumor of bone, the malignancy of which was assigned to a carcinosarcoma, i.e., osteosarcoma and squamous cell carcinoma. It occurred 25 years after curettage and bone graft surgery under the diagnosis of giant cell tumor of the right distal femur. Although secondary malignant giant cell tumor is known as a sarcoma arising at the site of a previously diagnosed giant cell tumor, this case should be regarded as a new type of secondary malignant giant cell tumor of bone.
authors.affiliation: Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Ariake 3-10-6, Kouto-ku, Tokyo 135-8550, Japan. machinami-tky@umin.ac.jp
authors.forename: Rikuo
authors.initials: R
authors.lastname: Machinami
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishida
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ishida
authors.forename: Seiichi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Kouji
authors.initials: K
authors.lastname: Kuroda
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kengo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
mesh_terms: D000671:Amputation, Surgical; D016025:Bone Transplantation; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002296:Carcinosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003475:Curettage; D017809:Fatal Outcome; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D009626:Terminology as Topic