Quantifying collagen in mouse kidneys.
Identification of genes underlying quantitative trait loci (QTLs) represents a formidable task. Recent advances in the annotation of the mouse genome and the availability of newly developed mouse strains should boost gene discovery. Kato and colleagues report the localization of a QTL for collagen type I deposition in kidneys on mouse chromosome 2, representing the first step for the identification of a gene involved in interstitial fibrosis, an important pathway in progression to end-stage renal failure in many kidney disorders.
Sanna-Cherchi
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Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. ss2517@columbia.edu
D000818:Animals; D024042:Collagen Type I / Q000032:analysis* / Q000235:genetics* / Q000378:metabolism; D007668:Kidney / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D040641:Quantitative Trait Loci
D024042:Collagen Type I