title: Prevalence of cystic macular lesions in patients with Usher II syndrome.
abstract: OBJECTIVE
  To evaluate the prevalence of cystic macular lesions in patients with Usher II syndrome.
  
  
  METHODS
  All Usher type II patients seen in the inherited eye disease clinic at the University of Illinois at Chicago between January 2002 and December 2007 were included (n=76). Each participating patient underwent a detailed clinical examination, including best-corrected visual acuity, slit-lamp biomicroscopy and dilated fundus examination. The presence of cystoid lesions was determined by optical coherence tomography (OCT), fundus fluorescein angiogram (FFA), fundus photographs and/or clinical examination.
  
  
  RESULTS
  A cystic-appearing macular change was observed in at least one eye in 19 out of the 76 patients (25%), 13 on the basis of OCT, five using FFA (two solely with the use of FFA and three based on clinical notes and FFA findings) and one based solely on clinical notes. Of the 18 patients with CME, determined by OCT or FFA, five (27.8%) showed either a funduscopically normal-appearing macula (n=4) or an atrophic appearing macular change (n=1).
  
  
  CONCLUSIONS
  One-fourth of our total cohort of Usher II patients had cystic macular lesions. Moreover, a funduscopically normal-appearing macula was observed in 22% (n=4) of our 18 patients with cystic-appearing macular lesions on OCT and/or FFA testing. On the basis of the reasonably high prevalence of cystic macular lesions in our cohort, it would seem prudent to evaluate Usher II patients for the presence of cystoid macular oedema.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: S
authors.initials: S
authors.lastname: Walia
authors.forename: G A
authors.initials: GA
authors.lastname: Fishman
authors.forename: M
authors.initials: M
authors.lastname: Hajali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D003560:Cysts / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D052245:Usher Syndromes / Q000150:complications*; D014792:Visual Acuity; D055815:Young Adult