Development of carcinoid tumors of the glandular stomach and effects of eradication in Helicobacter pylori-infected Mongolian gerbils.
The relation between Helicobacter pylori (Hp) eradication and prevention of stomach carcinoid development has hitherto remained unclear. We therefore examined this problem using an Hp-infected and Hp-eradicated Mongolian gerbil (MG) model. Enterochromaffin-like (ECL) lesions (hyperplasia/dysplasia and carcinoid) were histopathologically evaluated in the glandular stomachs of Hp-infected and Hp-eradicated MGs. In addition, serum gastrin levels were analyzed. Hp infection induced significant increase in the development of ECL lesions in the glandular stomach, as well as serum gastrin levels as compared with non-infected MGs, while Hp eradication was associated with significant alleviation. The development of ECL lesions in the glandular stomach strongly correlated with titers of anti-Hp antibodies and serum gastrin levels in MGs. In conclusion, Hp infection induces carcinoid development, and Hp eradication prevents its occurrence in the glandular MG stomach, this being strongly linked with reduction in serum gastrin levels.
Cao
Liyu
L
Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa, Nagoya, Japan.
Mizoshita
Tsutomu
T
Tsukamoto
Tetsuya
T
Takenaka
Yoshiharu
Y
Toyoda
Takeshi
T
Cao
Xueyuan
X
Ban
Hisayo
H
Nozaki
Koji
K
Tatematsu
Masae
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002276:Carcinoid Tumor / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D019861:Enterochromaffin-like Cells / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects / Q000472:pathogenicity*; D006965:Hyperplasia; D008297:Male; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D005755:Gastrins