title: Spectrum of pleiotropic effects of statins in heart failure.
abstract: The syndrome of heart failure is characterized by increased levels of circulating inflammatory mediators, which have been implicated in the pathogenesis of heart failure. Recently, a number of studies have suggested that statins may exert salutary effects in patients who have heart failure by virtue of their pleiotropic (non-lipid lowering) actions. This article focuses on the non-lipid lowering effects of statins, with an emphasis on the anti-inflammatory properties of these agents.
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Mathur
authors.forename: Kumudha
authors.initials: K
authors.lastname: Ramasubbu
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
mesh_terms: D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors