The polymorphisms of protein-tyrosine phosphatase receptor-type delta gene and its association with pediatric asthma in the Taiwanese population.
We previously reported an association between genetic differences of pediatric asthma subtypes and a short tandem repeat (STR) marker, D9S286. It has been known that the protein-tyrosine phosphatase receptor-type delta (PTPRD) gene is located downstream of D9S286 and that the physical distance between them is about 0.25 Mb. We selected and conducted genotyping on 76 single-nucleotide polymorphisms (SNPs) that encircle the genomic region of PTPRD in Taiwanese children with or without asthma. A total of 996 subjects were divided into testing group (674 subjects) and validation group (322 subjects). The results were further validated with the third subject group (611 subjects) recruited from different geographical regions. After Bonferroni correction, 3 out of 80 SNPs were found to be strongly significant (P < 0.05/76 = 0.000658) in the allele frequency test. This association was confirmed by validation groups. The results indicate that polymorphisms of PTPRD are strongly associated with pediatric bronchial asthma in the Taiwanese population.
Shyur
Shyh-Dar
SD
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
Wang
Jiu-Yao
JY
Lin
Cherry Guan-Ju
CG
Hsiao
Ya-Hsin
YH
Liou
Ya-Huei
YH
Wu
Ying-Jye
YJ
Wu
Lawrence Shih-Hsin
LS
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000201:enzymology* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003710:Demography; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2 / Q000235:genetics*; D015203:Reproducibility of Results; D013624:Taiwan
C090899:PTPRD protein, human; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2