title: Synthesis of maremycins A and D1 via cycloaddition of a nitrone with (E)-3-ethylidene-1-methylindolin-2-one.
abstract: A concise synthesis of maremycins A and D1 has been accomplished via cycloaddition of a chiral cyclic nitrone with ( E)-3-ethylidene-1-methylindolin-2-one as a key step. This synthesis clarifies the stereochemistry of the maremycins and is suitable for large-scale synthesis for biological screening.
authors.affiliation: Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Ueda
authors.forename: Mitsuhide
authors.initials: M
authors.lastname: Inada
authors.forename: Iwao
authors.initials: I
authors.lastname: Okamoto
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Morita
authors.forename: Osamu
authors.initials: O
authors.lastname: Tamura
mesh_terms: D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C529949:(E)-3-ethylidene-1-methylindolin-2-one; D007211:Indoles; D009589:Nitrogen Oxides; C529950:maremycin A; C529951:maremycin D1; C015388:nitrones