title: Novel types of carborane-carrier hyaluronan derivatives via "click chemistry".
abstract: Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells.
authors.affiliation: Department of Chemistry, University of Rome "La Sapienza", p. le Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Di Meo
authors.forename: Luigi
authors.initials: L
authors.lastname: Panza
authors.forename: Federica
authors.initials: F
authors.lastname: Campo
authors.forename: Donatella
authors.initials: D
authors.lastname: Capitani
authors.forename: Luisa
authors.initials: L
authors.lastname: Mannina
authors.forename: Alessandra
authors.initials: A
authors.lastname: Banzato
authors.forename: Maria
authors.initials: M
authors.lastname: Rondina
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosato
authors.forename: Vittorio
authors.initials: V
authors.lastname: Crescenzi
mesh_terms: D001895:Boron / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000188:drug therapy*; D014131:Trace Elements / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D014131:Trace Elements; D006820:Hyaluronic Acid; D001895:Boron