title: Synthesis of 2'-O-beta-d-Ribofuranosylnucleosides.
abstract: A simple and efficient method for the preparation of 2-O-beta-D-ribofuranosylnucleosides, minor tRNA components, is described in this unit. The method consists of condensation of a small excess of 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose activated with tin tetrachloride with N-protected 3,5-O-tetra-isopropyldisiloxane-1,3-diyl-ribonucleosides in 1,2-dichloroethane. Subsequent deprotection produces 2-O-beta-D-ribofuranosylnucleosides in an overall yield of 46% to 72%.
authors.affiliation: Russian Academy of Sciences, Engelhardt Institute of Molecular Biology, Moscow, Russia.
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Mikhailov
authors.forename: Ekaterina V
authors.initials: EV
authors.lastname: Efimtseva
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Rodionov
authors.forename: Georgii V
authors.initials: GV
authors.lastname: Bobkov
authors.forename: Irina V
authors.initials: IV
authors.lastname: Kulikova
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D002855:Chromatography, Thin Layer; D005663:Furans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005663:Furans; D012263:Ribonucleosides