title: Massive pulmonary embolism with cardiac arrest treated with continuous thrombolysis and concomitant hypothermia.
abstract: This case report describes the clinical course in a 49-year-old man with repeated cardiac arrests due to massive pulmonary embolism. He was successfully treated with intravenous tenecteplase followed by catheter-based alteplase infusion during external cooling. The case illustrates that vitally important bolus thrombolytic therapy may be continued as catheter-based treatment along with hypothermia without significant bleeding complications.
authors.affiliation: Coronary Care Unit, Medical Department, Nordland Hospital, 8092 Bodo, Norway. a-hovlan@online.no
authors.forename: A
authors.initials: A
authors.lastname: Hovland
authors.forename: H
authors.initials: H
authors.lastname: Bjørnstad
authors.forename: R F
authors.initials: RF
authors.lastname: Hallstensen
authors.forename: K A
authors.initials: KA
authors.lastname: Hugaas
authors.forename: J A
authors.initials: JA
authors.lastname: Westlie
authors.forename: T
authors.initials: T
authors.lastname: Elden
authors.forename: K
authors.initials: K
authors.lastname: Andersen
mesh_terms: D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D007036:Hypothermia, Induced; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D000077785:Tenecteplase; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase