Weight loss of black, white, and Hispanic men and women in the Diabetes Prevention Program.
OBJECTIVE
To provide the specific weight loss outcomes for African-American, Hispanic, and white men and women in the lifestyle and metformin treatment arms of the Diabetes Prevention Program (DPP) by race-gender group to facilitate researchers translating similar interventions to minority populations, as well as provide realistic weight loss expectations for clinicians.


METHODS
Secondary analyses of weight loss of 2,921 overweight participants (22% black; 17% Hispanic; 61% white; and 68% women) with impaired glucose tolerance randomized in the DPP to intensive lifestyle modification, metformin or placebo. Data over a 30-month period are examined for comparability across treatment arms by race and gender.


RESULTS
Within lifestyle treatment, all race-gender groups lost comparable amounts of weight with the exception of black women who exhibited significantly smaller weight losses (P < 0.01). For example, at 12 months, weight losses for white men (-8.4%), white women (-8.1%), Hispanic men (-7.8%), Hispanic women (-7.1%), and black men (-7.1%) were similar and significantly higher than black women (-4.5%). In contrast, within metformin treatment, all race-gender groups including black women lost similar amounts of weight. Race-gender specific mean weight loss data are provided by treatment arm for each follow-up period.


CONCLUSIONS
Diminished weight losses were apparent among black women in comparison with other race-gender groups in a lifestyle intervention but not metformin, underscoring the critical nature of examining sociocultural and environmental contributors to successful lifestyle intervention for black women.
West
Delia S
DS
Department of Health Behavior and Health Education, University of Arkansas for Medical Sciences, Fay W. Boozman College of Public Health, Little Rock, Arkansas, USA. WestDelia@uams.edu
Elaine Prewitt
T
T
Bursac
Zoran
Z
Felix
Holly C
HC
D000328:Adult; D001741:Black or African American; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000208:ethnology* / Q000517:prevention & control*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style / Q000208:ethnology; D008137:Longitudinal Studies; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D044469:Racial Groups; D012737:Sex Factors; D016896:Treatment Outcome; D014481:United States; D015431:Weight Loss; D044465:White People
D007004:Hypoglycemic Agents; D008687:Metformin