title: Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs.
abstract: Preliminary studies showed spinosad to be rapidly effective and safe in controlling fleas on dogs. To validate these studies, a clinical trial was undertaken using 470 flea-infested client-owned dogs allocated to receive three monthly treatments with either beef-flavored chewable spinosad tablets (30-60 mg/kg) or selamectin applied according to label instructions. Flea counts 15 days after enrollment were reduced by 98.6% and 90.9% for spinosad- and selamectin-treated dogs, respectively; at 90 days, flea count reductions were 99.9% and 98.9%, respectively. Compared with baseline, all flea reductions were significant (P < .001) for both products and spinosad was significantly (P ≤ .0172) more effective than selamectin at each postenrollment flea count.
authors.affiliation: Elanco Animal Health.
authors.forename: Carol
authors.initials: C
authors.lastname: Robertson-Plouch
authors.forename: Keith A
authors.initials: KA
authors.lastname: Baker
authors.forename: Rebecca R
authors.initials: RR
authors.lastname: Hozak
authors.forename: Alan G
authors.initials: AG
authors.lastname: Zimmermann
authors.forename: S Craig
authors.initials: SC
authors.lastname: Parks
authors.forename: Cory
authors.initials: C
authors.lastname: Herr
authors.forename: Liane M
authors.initials: LM
authors.lastname: Hart
authors.forename: Jeff
authors.initials: J
authors.lastname: Jay
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Hutchens
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Snyder
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D004338:Drug Combinations; D058267:Flea Infestations / Q000517:prevention & control / Q000662:veterinary*; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets
chemical_list: D004338:Drug Combinations; D007306:Insecticides; D018942:Macrolides; D013607:Tablets; C415329:spinosad