Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
The concentration of peripheral type benzodiazepine binding sites (PTBS) in the brain parenchyma is greatly increased following brain lesions, reflecting the glial reaction and/or presence of hematogenous cells. Thus, PTBS density is a sensitive and reliable marker of brain injury in a large number of experimental models (ischemia, trauma, excitotoxic lesions, brain tumors) and equivalent human neuropathological conditions. PTBS density can be measured using specific radioligands and a conventional binding technique, or by quantitative autoradiography in tissue sections.
Benavides
J
J
Synthélabo Recherche, Bagneux Cédex, France.
Dubois
A
A
Scatton
B
B
D000818:Animals; D001345:Autoradiography / Q000379:methods*; D015415:Biomarkers; D001923:Brain Chemistry; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism; D002352:Carrier Proteins / Q000032:analysis*; D003292:Convulsants / Q000494:pharmacology / Q000633:toxicity; D007546:Isoquinolines / Q000032:analysis; D051379:Mice; D016202:N-Methylaspartate / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009498:Neurotoxins / Q000494:pharmacology / Q000633:toxicity; D011485:Protein Binding; D011869:Radioligand Assay / Q000379:methods*; D051381:Rats; D018079:Receptors, GABA / Q000032:analysis*; D011963:Receptors, GABA-A / Q000032:analysis*
D015415:Biomarkers; D002352:Carrier Proteins; D003292:Convulsants; D007546:Isoquinolines; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D018079:Receptors, GABA; D011963:Receptors, GABA-A; C499229:TSPO protein, human; C069997:Tspo protein, rat; D016202:N-Methylaspartate; C037850:PK 11195