Solubilisation of drugs in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide.
The solubilisation of two poorly soluble drugs, furosemide and nabumetone, in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide has been studied at 25 and 37 degrees C and solubilisation capacities compared with published values for griseofulvin and docetaxel. Solubilisation in the micelle core, corrected for the different proportions of poly(styrene oxide) in the copolymers, was similar for all four drugs. The highest solubilisation capacities were found for a copolymer with worm-like micelles.
Crothers
Michael
M
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.
Ricardo
Nagíla M P S
NM
Heatley
Frank
F
Nixon
S Keith
SK
Attwood
David
D
Booth
Colin
C
D002074:Butanones / Q000737:chemistry; D005665:Furosemide / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D000077430:Nabumetone; D004364:Pharmaceutical Preparations / Q000737:chemistry; D019999:Pharmaceutical Solutions; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D011137:Polystyrenes / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D002074:Butanones; D008823:Micelles; D004364:Pharmaceutical Preparations; D019999:Pharmaceutical Solutions; D011108:Polymers; D011137:Polystyrenes; C103390:polyethylene glycol-polystyrene; D011092:Polyethylene Glycols; D005665:Furosemide; D000077430:Nabumetone