title: Association study of the CFH Y402H polymorphism with Alzheimer's disease.
abstract: Several reports indicated that Alzheimer's disease (AD) and age-related macular degeneration (AMD) may share similar genetic and pathological features. We postulated that the functional Y402H polymorphism within the CFH gene and unambiguously recognised as a major genetic determinant of AMD, may also be a risk factor of AD. We analysed the association of this polymorphism with the AD risk in both prospective and cross-sectional studies. We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD.
authors.affiliation: INSERM U744, Institut Pasteur de Lille, Université de Lille 2, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Le Fur
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Laumet
authors.forename: Florence
authors.initials: F
authors.lastname: Richard
authors.forename: Nathalie
authors.initials: N
authors.lastname: Fievet
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.forename: Olivier
authors.initials: O
authors.lastname: Rouaud
authors.forename: Cécile
authors.initials: C
authors.lastname: Delcourt
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D017242:Complement Factor H / Q000235:genetics; D003430:Cross-Sectional Studies; D004252:DNA Mutational Analysis; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies / Q000379:methods*; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies
chemical_list: C493495:CFH protein, human; D005819:Genetic Markers; D017242:Complement Factor H