Exposure assessment of prepubertal children to steroid endocrine disruptors. 2. Determination of steroid hormones in milk, egg, and meat samples.
In the present study, the occurrence of the main sex steroid hormones in milk, egg, and meat was evaluated on the basis of a highly specific gas chromatography-tandem mass spectrometry measurement method. Globally, the results indicated that targeted estrogens and androgens occurred at similar levels (concentration levels in the 10-100 ng kg (-1) range) in the analyzed muscle and milk samples. The same compounds occurred at about 10-fold higher concentrations (i.e., in the 100-1000 ng kg (-1) range) in eggs and kidney samples. More precisely, egg and milk appeared as a non-negligible sources of estradiol (i.e., 2.2 +/- 0.8 and 3.1 +/- 2.0 ng day (-1), respectively), whereas testosterone exposure is caused by ingestion of meat and/or egg (i.e., 12.2 +/- 48.2 and 5.2 +/- 2.3 ng day (-1), respectively). The provided exposure data will be further exploited in the scope of a risk assessment study regarding endocrine disruption associated with these molecules.
Courant
Frédérique
F
Laboratoire d'Etude des Résidus et Contaminants dans les Aliments, Ecole Nationale Vétérinaire de Nantes, USC 2013 INRA, B P 50707, F-44307 Nantes, Cedex 3, France.
Antignac
Jean-Philippe
JP
Laille
Julie
J
Monteau
Fabrice
F
Andre
François
F
Le Bizec
Bruno
B
D000728:Androgens / Q000032:analysis; D000818:Animals; D002675:Child, Preschool; D004531:Eggs / Q000032:analysis*; D052244:Endocrine Disruptors / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D004781:Environmental Exposure; D004967:Estrogens / Q000032:analysis; D006801:Humans; D008460:Meat / Q000032:analysis*; D008892:Milk / Q000737:chemistry*; D011627:Puberty
D000728:Androgens; D052244:Endocrine Disruptors; D004967:Estrogens