title: Correlation between electrocorticographic and motor phenomena in lindane-induced experimental epilepsy in rats.
abstract: We report a study on the relation between open-field behavior and electroencephalographic (EEG) changes during lindane-induced seizures in 2-month-old adult male Wistar rats. For chronic EEG recordings and power spectra analysis, 3 electrodes were implanted into the skull. Three groups of animals, (i) saline-injected control (n = 6), (ii) DMSO-treated (n = 6), and (iii) lindane intraperitoneally administered: L(4) (4 mg/kg, n = 10), L(6) (6 mg/kg, n = 11), and L(8) (8 mg/kg, n = 11), were observed for 30 min for the occurrence of convulsive behavior. It was assessed by incidence of motor seizures, and seizure severity grade was determined by a descriptive rating scale (0, no response; 1, head nodding, lower jaw twitching; 2, myoclonic body jerks, bilateral forelimb clonus with full rearing; 3, progression to generalized clonic convulsions followed by tonic extension of fore and hind limbs and tail; 4, status epilepticus). EEG signal and spectral analyses were suitable to describe the dynamics of complex behavioral responses. Incidence and severity of epileptic manifestations, recorded as high voltage spike-wave complexes, polyspikes, sleep-like patterns in EEG, and power spectra changes, were greater in lindane-treated groups in a dose-dependent manner compared with control or DMSO-treated groups. Our results suggest good correlation between lindane-induced epileptiform activity and behavioral changes.
authors.affiliation: Department of Pathophysiology, School of Medicine, University of Belgrade, Dr Subotića 9, 11000 Belgrade, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Vucević
authors.forename: Dragan
authors.initials: D
authors.lastname: Hrncić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Radosavljević
authors.forename: Dusan
authors.initials: D
authors.lastname: Mladenović
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rasić-Marković
authors.forename: Helena
authors.initials: H
authors.lastname: Loncar-Stevanović
authors.forename: Dragan
authors.initials: D
authors.lastname: Djurić
authors.forename: Djuro
authors.initials: D
authors.lastname: Macut
authors.forename: Veselinka
authors.initials: V
authors.lastname: Susić
authors.forename: Olivera
authors.initials: O
authors.lastname: Stanojlović
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D005583:Fourier Analysis; D001556:Hexachlorocyclohexane / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D001556:Hexachlorocyclohexane