A primer on ankyrin repeat function in TRP channels and beyond.
Transient receptor potential (TRP) channels are rapidly gaining attention as important receptors and transducers of diverse sensory and environmental cues. Recent progress in the field has provided new insights into the structure and function of the ankyrin repeat motifs present in the N-terminal cytosolic domain of many TRP channels. The topics addressed in this Highlight include the structural features of canonical ankyrin repeats, new clues into the functions these repeats perform in cells, and how this information can be applied to develop further experiments on TRP channels and other proteins containing ankyrin repeats.
Gaudet
Rachelle
R
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 01238, USA. gaudet@mcb.harvard.edu
D017089:Ankyrin Repeat / Q000502:physiology*; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D050051:Transient Receptor Potential Channels / Q000737:chemistry* / Q000502:physiology*
D008024:Ligands; D050051:Transient Receptor Potential Channels