title: Overview of pepsin-like aspartic peptidases.
abstract: The aspartic peptidase family of enzymes has been implicated in a variety of disease states, from stomach ulcers, to breast cancer, and even Alzheimer's Disease. This unit describes the major characteristics of the aspartic peptidases, including mechanism of action, subcellular and tissue localization, and biological substrate specificity.
authors.affiliation: University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Dunn
mesh_terms: D000595:Amino Acid Sequence; D016282:Aspartic Acid Endopeptidases / Q000737:chemistry* / Q000378:metabolism*; D002384:Catalysis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010434:Pepsin A / Q000378:metabolism*; D017433:Protein Structure, Secondary; D013379:Substrate Specificity
chemical_list: D016282:Aspartic Acid Endopeptidases; D010434:Pepsin A