title: The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma.
abstract: BACKGROUND
  Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally.
  
  
  METHODS
  In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion of chromosomes 1p and 19q, a marker of good prognosis, could be predicted accurately by measuring image texture.
  
  
  RESULTS
  Differences in texture were seen between tumors with codeletion of chromosomes 1p and 19q and those with intact 1p and 19q alleles on contrast-enhanced T1-weighted and T2-weighted MR images. Quantitative MR texture on T2 images predicted codeletion of chromosomes 1p and 19q with high sensitivity and specificity.
  
  
  CONCLUSIONS
  This new method of MR image interpretation may have the potential to augment the diagnostic assessment of patients with suspected low-grade glioma.
authors.affiliation: Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Brown
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zlatescu
authors.forename: Angelique
authors.initials: A
authors.lastname: Sijben
authors.forename: Gloria
authors.initials: G
authors.lastname: Roldan
authors.forename: Jay
authors.initials: J
authors.lastname: Easaw
authors.forename: Peter
authors.initials: P
authors.lastname: Forsyth
authors.forename: Ian
authors.initials: I
authors.lastname: Parney
authors.forename: Robert
authors.initials: R
authors.lastname: Sevick
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Yan
authors.forename: Douglas
authors.initials: D
authors.lastname: Demetrick
authors.forename: David
authors.initials: D
authors.lastname: Schiff
authors.forename: Gregory
authors.initials: G
authors.lastname: Cairncross
authors.forename: Ross
authors.initials: R
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009837:Oligodendroglioma / Q000235:genetics*