title: Total-body contrast-enhanced MRA on a short, wide-bore 1.5-T system: intra-individual comparison of Gd-BOPTA and Gd-DOTA.
abstract: Total-body contrast-enhanced MRA (CE-MRA) provides information of the entire vascular system according to a one-stop-shop approach. Short, wide-bore scanners have not yet been used for total-body CE-MRA, probably due to their restricted field of view in the z-direction. The purpose of this feasibility study is to introduce an image protocol for total-body MRA on a short, wide-bore system. The protocol includes five to six table-moving steps and two injection runs. Two pharmacologically different contrast materials (CM) were applied in ten healthy volunteers in view of possible CM-dependent influences on the protocol outcome (Gd-Bopta, Gd-Dota). Differences consisted of significantly higher CNR with Gd-Bopta with a mean of 73.8+/-38.7 versus 69.1+/-34.3 (p=0.008), significantly better arterial visualization values with Gd-Dota with a mean of 1.26+/-0.44 versus 1.53+/-0.73 (p=0.003) and a tendency to less venous overlay with Gd-Dota, mean 1.19+/-0.44 and 1.34+/-0.72, respectively (p=0.065) (two-tailed Wilcoxon matched-pairs test). Overall 94% of the steps were valued as qualitatively excellent or good. The good results with both CM suggest a transfer to further patient evaluation.
authors.affiliation: Department of Radiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. mrasmus@uhbs.ch
authors.forename: M
authors.initials: M
authors.lastname: Rasmus
authors.forename: J
authors.initials: J
authors.lastname: Bremerich
authors.forename: T
authors.initials: T
authors.lastname: Egelhof
authors.forename: R W
authors.initials: RW
authors.lastname: Huegli
authors.forename: G
authors.initials: G
authors.lastname: Bongartz
authors.forename: D
authors.initials: D
authors.lastname: Bilecen
mesh_terms: D000328:Adult; D001158:Arteries / Q000033:anatomy & histology*; D003287:Contrast Media; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005260:Female; D006571:Heterocyclic Compounds; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009942:Organometallic Compounds; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate