title: Mental neuropathy as a manifestation associated with malignant processes: its significance in relation to patient survival.
abstract: OBJECTIVE
  Mental neuropathy (MN) is characterized by the presence of a sensory defect in the form of paresthesias or dysesthesias in the territory innervated by the mental nerve. MN may be the first manifestation of systemic cancer, a symptom of spread of an established tumor, or a sign of infiltration in an intraoral lesion. In any of these cases, the symptom is indicative of a very poor patient prognosis.
  
  
  METHODS
  A total of 22 cancer patients with chin paresthesia were studied. Group 1 comprised patients with chin paresthesia who had a primary tumor in some other region at a distance from the oral cavity or maxillofacial zone. Group 2 in turn comprised patients with primary malignancies of the oral and/or maxillofacial territory and who likewise presented with chin paresthesia. Data were collected relating to patient age, gender, primary intraoral lesion (location, size, histologic diagnosis), primary systemic tumor, and mean patient survival.
  
  
  RESULTS
  Group 1 consisted of 11 patients (8 men and 3 women), aged between 36 and 81 years (mean, 58.09 +/- 14.99 years), with different systemic cancers. The mean survival after the diagnosis of chin paresthesia was 14.8 +/- 16.5 months, and only 1 patient was still alive after 9 months. Group 2 consisted of 11 patients (8 men and 3 women), aged between 33 and 72 years (mean, 56.18 +/- 15.69 years). All presented with oral squamous cell carcinoma, with the single exception of 1 case of fibrosarcoma. In this group the mean survival of the 8 patients who died was 28.2 +/- 29.6 months. Three patients survived for a mean of 17 months.
  
  
  CONCLUSIONS
  Chin paresthesia is a very important prognostic symptom determining the degree of infiltration of intraoral lesions, and in some cases it may be indicative of the existence of a primary tumor (identified or otherwise), with poor short-term survival--given that 81.9% of the patients studied (18 cases) had died before a mean of 20 months. Although mean survival was shorter (14.8 months) among the patients in group 1 than in group 2 (28.2 months), the difference was not statistically significant.
authors.affiliation: Service of Stomatology, Valencia University General Hospital, Valencia University Medical and Dental School, Valencia, Spain. Sanchisj@uv.es
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Sanchis
authors.forename: Jose Vicente
authors.initials: JV
authors.lastname: Bagán
authors.forename: Judith
authors.initials: J
authors.lastname: Murillo
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Díaz
authors.forename: Rafael
authors.initials: R
authors.lastname: Poveda
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jiménez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000401:mortality / Q000556:secondary; D002680:Chin / Q000294:innervation; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000209:etiology*; D008297:Male; D008340:Mandibular Nerve / Q000503:physiopathology*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications* / Q000401:mortality / Q000556:secondary; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate