title: Elevated third-trimester haemoglobin A 1c predicts preterm delivery in type 1 diabetes.
abstract: The prevalence of preterm delivery is considerably elevated in women with type 1 diabetes. The aim of the study was to evaluate haemoglobin A(1c) (HbA(1c)) as a predictor of preterm delivery. Two hundred thirteen consecutive pregnant women with type 1 diabetes and normal urinary albumin excretion were included prospectively. HbA(1c) was analyzed at 10, 20 and 28 weeks of gestation. Seventy-one women (33%) delivered pre term and 142 at term. At 10 weeks of gestation, HbA(1c) was 7.3% (S.D. 1.0) vs. 6.9% (S.D. 0.9) (P<.01), at 20 weeks of gestation 6.6% (S.D. 0.7) vs. 6.1% (S.D. 0.7) (P<.001) and at 28 weeks of gestation 6.7% (S.D. 0.8) vs. 6.1% (S.D. 0.7) (P<.001). When comparing HbA(1c) at 10, 20 and 28 weeks of gestation, HbA(1c) at 28 weeks of gestation (P<.001) was the best predictor of preterm delivery. The adjusted odds ratio per 1% increment in HbA(1c) at 28 weeks of gestation was 2.8 (95% CI 1.7-4.4). HbA(1c) at 28 weeks of gestation was a clinical significant predictor of preterm delivery in type 1 diabetes.
authors.affiliation: Endocrine Clinic, The National University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Pia
authors.initials: P
authors.lastname: Ekbom
authors.forename: Peter
authors.initials: P
authors.lastname: Damm
authors.forename: Bo
authors.initials: B
authors.lastname: Feldt-Rasmussen
authors.forename: Ulla
authors.initials: U
authors.lastname: Feldt-Rasmussen
authors.forename: Dorte M
authors.initials: DM
authors.lastname: Jensen
authors.forename: Elisabeth R
authors.initials: ER
authors.lastname: Mathiesen
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000150:complications; D007231:Infant, Newborn; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood*; D047928:Premature Birth / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors; D015854:Up-Regulation
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human