Lack of association between Helicobacter pylori and laryngeal carcinoma.
OBJECTIVE
To survey the role of Helicobacter pylori at the tissue level as a cause of squamous cell carcinoma of the larynx.


METHODS
A case-control study.


METHODS
In an Otolaryngology Ward at an academic university.


METHODS
Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls.


METHODS
In all subjects, specimens of laryngeal tissue were examined by rapid urease test while histopathologic examination was achieved to detect H. Pylori.


RESULTS
Totally, 44 patients (42 men and 2 women) with squamous cell carcinoma of larynx and 30 patients (24 men and 6 women) with benign laryngeal lesions (polyp, nodule, granuloma) were studied, none of which were infected with the bacterium.


CONCLUSIONS
Our results did not show H. Pylori infection among patients with laryngeal cancer (SCC) or benign laryngeal lesions. .
Masoud
Naderpour
N
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Iran.
Manouchehr
Khoshbaten
K
Najmeh
Doostmohammadian
D
Monireh
Halimi
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000382:microbiology* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014510:Urease / Q000378:metabolism
D014510:Urease