Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.
Reiner
Alexander P
AP
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA. apreiner@u.washington.edu
Barber
Mathew J
MJ
Guan
Yongtao
Y
Ridker
Paul M
PM
Lange
Leslie A
LA
Chasman
Daniel I
DI
Walston
Jeremy D
JD
Cooper
Gregory M
GM
Jenny
Nancy S
NS
Rieder
Mark J
MJ
Durda
J Peter
JP
Smith
Joshua D
JD
Novembre
John
J
Tracy
Russell P
RP
Rotter
Jerome I
JI
Stephens
Matthew
M
Nickerson
Deborah A
DA
Krauss
Ronald M
RM
D000368:Aged; D001499:Bayes Theorem; D002097:C-Reactive Protein / Q000235:genetics*; D005260:Female; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017035:Pravastatin / Q000627:therapeutic use; D019821:Simvastatin / Q000627:therapeutic use
C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein; D019821:Simvastatin; D017035:Pravastatin