title: Granulocyte-colony stimulating factor for the treatment of ritodrine-induced neutropenia.
abstract: We report on three pregnant women with ritodrine-induced neutropenia who were successfully treated with granulocyte-colony stimulating factor (G-CSF). The neutropenia occurred after continuous intravenous infusion of ritodrine for preterm labor. Ritodrine was discontinued and G-CSF was administered. Neutrophil counts returned to normal an average of 4.3 days after the administration. No infectious morbidity or adverse side-effects occurred in the mothers or infants. G-CSF is one possible treatment in women with ritodrine-induced neutropenia.
authors.affiliation: Department of Obstetrics, Gynecology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kikkawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsubara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takatoku
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kuwata
authors.forename: Akihide
authors.initials: A
authors.lastname: Ohkuchi
authors.forename: Akio
authors.initials: A
authors.lastname: Izumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D009503:Neutropenia / Q000139:chemically induced* / Q000188:drug therapy*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D012312:Ritodrine / Q000009:adverse effects* / Q000627:therapeutic use; D015149:Tocolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D015149:Tocolytic Agents; D016179:Granulocyte Colony-Stimulating Factor; D012312:Ritodrine