Significant improvement in extensive lichen sclerosus with tacrolimus ointment and PUVA.
Lichen sclerosus is an uncommon, chronic inflammatory skin disorder of unknown origin. It is clinically characterized by sclerotic, whitish, atrophic-type lesions. The most frequent site of the lesions is generally the genital region, with about 15-20% having additional extragenital involvement. We present the case of a 62-year-old woman with a very extensive extragenital lichen sclerosus who showed great clinical and subjective improvement with 0.1% tacrolimus ointment and psoralen plus UVA (PUVA), without any topical or systemic adverse effects. Combined treatment of 0.1% tacrolimus ointment and PUVA may be a good option in extensive cases of lichen sclerosus or when other treatment options have failed, and has a good tolerability and safety profile.
Valdivielso-Ramos
Marta
M
Dermatology Department, Hospital Virgen de la Torre, Madrid, Spain. martavaldivielso@aed.es
Bueno
Celso
C
Hernanz
José Manuel
JM
D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy*; D008875:Middle Aged; D009824:Ointments; D011701:PUVA Therapy; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus