[Effect of freeze-dried sea cucumber powder of eastern sea on tumor and immune index of S180-bearing mouse].
OBJECTIVE
To study the effect of freeze-dried sea cucumber powder from eastern sea on tumor and immune of S180-bearing mouse.


METHODS
S180 tumor cells were subcutaneouly inoculated to fifty health kunming mice and were randomly divided into five groups (model control group, positive control group, and low, medium, high dose groups). After the groups were orally treated with solution of freeze-dried sea cucumber powder for ten days,the weights of tumors and the inhibition rates of tumor were counted, and the pathological changes of tumors were observed and the expressions of caspase-3 proteins were detected in the tumor tissues, and the thymus index and spleen index were observed , the contents of interleukin-2(IL-2) in the serum were detected.


RESULTS
(1) In comparison with the control groups,the weights of tumor were declined and the inhibition rates of tumor were remarkably decreased in the treated groups. (2) The pathological changes of model control group were very obvious. The expressions of caspase-3 proteins in the treated group were more higher than those of model control groups, while were more lower than those of positive control groups. (3) The thymus index, spleen index in the treated group indicated an increased tendency. (4) The contents of IL-2 in the treated groups were more higher than those of other groups.


CONCLUSIONS
Freeze-dried sea cucumber powder could be effective antitumor and could protect and recovery the immune system of S180-bearing mice.
Zhou
Xiangying
X
School of Public Health,Shandong University, Jinan 250012, China.
Xu
Guifa
G
Shen
Bingxin
B
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D005260:Female; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D051379:Mice; D011208:Powders; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D012616:Sea Cucumbers / Q000737:chemistry*
D000970:Antineoplastic Agents; D007376:Interleukin-2; D008419:Materia Medica; D011208:Powders; C505409:Casp3 protein, mouse; D053148:Caspase 3