title: Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
abstract: Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.
authors.affiliation: University of Washington, Department of Epidemiology, Seattle, WA 98195, USA. apreiner@u.washington.edu
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Reiner
authors.forename: Mathew J
authors.initials: MJ
authors.lastname: Barber
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Guan
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Lange
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Walston
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Cooper
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Jenny
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Rieder
authors.forename: J Peter
authors.initials: JP
authors.lastname: Durda
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Smith
authors.forename: John
authors.initials: J
authors.lastname: Novembre
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: Matthew
authors.initials: M
authors.lastname: Stephens
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Nickerson
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Krauss
mesh_terms: D000368:Aged; D001499:Bayes Theorem; D002097:C-Reactive Protein / Q000235:genetics*; D005260:Female; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017035:Pravastatin / Q000627:therapeutic use; D019821:Simvastatin / Q000627:therapeutic use
chemical_list: C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein; D019821:Simvastatin; D017035:Pravastatin