title: Oral corticosteroid use for loss of flexion after primary anterior cruciate ligament reconstruction.
abstract: OBJECTIVE
  Postoperative loss of motion after anterior cruciate ligament (ACL) reconstruction can lead to suboptimal outcomes. Short-term low-dose oral corticosteroids are an option for nonsurgical management of this condition. The purpose of this study is to retrospectively review a series of patients treated with a single Medrol Dosepak (MDP) (Pfizer, New York, NY) in the early postoperative period for the treatment of loss of flexion, focusing on range of motion, objective instrumented stability measurements, and complications.
  
  
  METHODS
  From September 1, 2003, through January 1, 2007, 28 (11%) of 252 patients who underwent primary ACL reconstruction were treated with an MDP at a mean of 6.1 weeks postoperatively (range, 4 to 12 weeks; SD, 1.4 weeks) for early postoperative loss of motion. Of these 28 patients, 4 were not included because of unavailable clinical records. One patient who underwent combined ACL and posterior cruciate ligament reconstruction with medial collateral ligament repair was excluded from the analysis. Range-of-motion and KT-1000 (MEDmetric, San Diego, CA) measurements were independently recorded by a single examiner preoperatively, at 6 weeks postoperatively, and again at final follow-up evaluation at a mean of 10.4 months (range, 4 to 24 months; SD, 4.3 months).
  
  
  RESULTS
  The mean flexion deficit compared with the normal, contralateral knee at the time of treatment with an MDP was 31.3 degrees (range, -2 degrees to 55 degrees ; SD, 14.8 degrees ). Patients treated with an MDP showed a significant improvement in flexion deficit (mean, 29.2 degrees; range, 0 degrees to 60 degrees ; SD, 17.1 degrees ) after MDP treatment (P < .001). KT-1000 side-to-side differences at final examination were 2 mm or less in 22 of 23 patients (mean, 1 mm; range, 0 to 4 mm; SD, 1 mm). Of the 23 patients treated with an MDP, 5 (22%) were considered failures because they required surgical intervention for persistent loss of motion, resulting in a reoperation rate for loss of motion after primary ACL reconstruction of 2.0% (5/252). There were no documented complications of MDP treatment. Specifically, no patients treated with an MDP had a postoperative infection develop.
  
  
  CONCLUSIONS
  The use of oral corticosteroids, in the form of an MDP, was associated with a successful return of normal range of motion in 78% of patients with early postsurgical loss of flexion and near-normal extension after primary ACL reconstruction without any associated complications or decrease in objective instrumented stability measurements.
  
  
  METHODS
  Level IV, therapeutic case series.
authors.affiliation: National Naval Medical Center, Bethesda, Maryland, USA.
authors.forename: John-Paul H
authors.initials: JP
authors.lastname: Rue
authors.forename: Amon T
authors.initials: AT
authors.lastname: Ferry
authors.forename: Paul B
authors.initials: PB
authors.lastname: Lewis
authors.forename: Bernard R
authors.initials: BR
authors.lastname: Bach
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D016059:Range of Motion, Articular / Q000187:drug effects*; D019651:Plastic Surgery Procedures / Q000009:adverse effects*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone