title: Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy.
abstract: We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Parmeswaran
authors.initials: P
authors.lastname: Diagaradjane
authors.forename: Anil
authors.initials: A
authors.lastname: Shetty
authors.forename: James C
authors.initials: JC
authors.lastname: Wang
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Elliott
authors.forename: Jon
authors.initials: J
authors.lastname: Schwartz
authors.forename: Shujun
authors.initials: S
authors.lastname: Shentu
authors.forename: Hee C
authors.initials: HC
authors.lastname: Park
authors.forename: Amit
authors.initials: A
authors.lastname: Deorukhkar
authors.forename: R Jason
authors.initials: RJ
authors.lastname: Stafford
authors.forename: Sang H
authors.initials: SH
authors.lastname: Cho
authors.forename: James W
authors.initials: JW
authors.lastname: Tunnell
authors.forename: John D
authors.initials: JD
authors.lastname: Hazle
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008027:Light; D008297:Male; D051379:Mice; D008819:Mice, Nude; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000627:therapeutic use*; D009389:Neovascularization, Pathologic / Q000473:pathology* / Q000628:therapy*; D011829:Radiation Dosage; D016896:Treatment Outcome
chemical_list: D006046:Gold