title: Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation.
abstract: Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein beta-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, P.R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Wu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Liu
authors.forename: Ding
authors.initials: D
authors.lastname: Li
mesh_terms: D000214:Acyl Coenzyme A / Q000737:chemistry* / Q000494:pharmacology*; D042964:Acyl-CoA Dehydrogenase / Q000037:antagonists & inhibitors / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D004746:Enoyl-CoA Hydratase / Q000037:antagonists & inhibitors / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry*; D063991:Mitochondrial Trifunctional Protein; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
chemical_list: D000214:Acyl Coenzyme A; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D009097:Multienzyme Complexes; C530366:oct-2-yn-4-enoyl-coenzyme A; D042964:Acyl-CoA Dehydrogenase; D063991:Mitochondrial Trifunctional Protein; D004746:Enoyl-CoA Hydratase