[First acute rejection episode after renal transplantation: study of the histopathological characteristics according to the immunological risk].
Renal allograft biopsies (n=34) of two different populations of patients according to the immunological risk (high versus low-risk) have been compared retrospectively. The presence of polymorphonuclear leukocytes in peritubular capillaries was more frequent in the high-risk group. The C4d staining was positive in 10% of the low-risk patients and in 50% of the high-risk patients (P=0.03). There were more early graft loss, renal infarctions, interstitial hemorrhage, severe glomerulitis, neutrophilic glomerulitis and Banff III grade rejection in the positive C4d group. In conclusion, half of the immunized patients had a humoral rejection, patients with a C4d positive rejection had more early graft loss and more severe histological lesions.
Ghisdal
Lidia
L
Service de néphrologie, hôpital académique ULB-Erasme, 808, route de Lennik, 1070 Bruxelles, Belgique. lghisdal@yahoo.com <lghisdal@yahoo.com>
Touchard
Guy
G
Goujon
Jean-Michel
JM
Buob
David
D
Durand
Dominique
D
Mourad
Georges
G
Lang
Philippe
P
Kessler
Michele
M
Snanoudj
Renaud
R
Berthoux
François
F
Merville
Pierre
P
Ouali
Nacéra
N
Squifflet
Jean-Paul
JP
Bayle
François
F
Bourgeon
Bruno
B
Rifle
Gérard
G
Peeters
Patrick
P
Delahousse
Michel
M
Legendre
Christophe
C
Bourbigot
Bernard
B
Noël
Christian
C
Abramowicz
Daniel
D
D000328:Adult; D001706:Biopsy; D015935:Complement C4b / Q000378:metabolism; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D012189:Retrospective Studies; D018570:Risk Assessment
D015935:Complement C4b