title: Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues.
abstract: OBJECTIVE
  The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues.
  
  
  METHODS
  Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time.
  
  
  RESULTS
  In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days.
  
  
  CONCLUSIONS
  Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.
authors.affiliation: School of Dentistry, University of Ribeirao Preto, Ribeirao Preto, Brazil.
authors.forename: Mônica Maria Denadae
authors.initials: MM
authors.lastname: de Campos-Pinto
authors.forename: Danilo Alessandro
authors.initials: DA
authors.lastname: de Oliveira
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Versiani
authors.forename: Yara Teresinha Correa
authors.initials: YT
authors.lastname: Silva-Sousa
authors.forename: Manoel Damião
authors.initials: MD
authors.lastname: de Sousa-Neto
authors.forename: Danyel Elias
authors.initials: DE
authors.lastname: da Cruz Perez
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D018836:Inflammation Mediators; D008027:Light; D008297:Male; D008422:Materials Testing; D009336:Necrosis; D051381:Rats; D012387:Root Canal Filling Materials / Q000633:toxicity*; D040521:Subcutaneous Tissue / Q000187:drug effects*; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D018836:Inflammation Mediators; D012387:Root Canal Filling Materials; C486893:epiphany sealer