Shedding light on developmental gene regulation through the lens.
My group has long studied transcriptional gene regulation involved in cell differentiation, employing lens cell differentiation as a model. In this article, our progress over the last quarter of a century in deciphering the principles involved in developmental gene regulation is described, outlining concurrent advancement in relevant branches of developmental biology.
Kondoh
Hisato
H
Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan. kondohh@fbs.osaka-u.ac.jp
D000818:Animals; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000378:metabolism; D015509:Developmental Biology / Q000379:methods*; D004742:Enhancer Elements, Genetic; D005347:Fibroblasts / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D050437:Genes, Developmental; D024002:HMGB Proteins / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000196:embryology* / Q000502:physiology; D008954:Models, Biological; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors / Q000378:metabolism; D014981:Xenopus; D029867:Xenopus Proteins
D004268:DNA-Binding Proteins; D024002:HMGB Proteins; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors; D029867:Xenopus Proteins; C527781:sox2 protein, Xenopus