title: Ocular central nervous system lymphoma mimicking choroidal neovascularization.
abstract: Two patients evaluated for metamorphopsia were noted to have inferotemporal retinal pigment epithelium elevations formed by a yellowish lesion. Fluorescein angiography showed granular hyperfluorescence with late leakage, which was interpreted as an occult choroidal neovascularization. One patient underwent photodynamic therapy. In both patients, neither vitreous cells nor neurologic manifestations were evident on presentation. Subsequent neurological signs appeared that prompted performance of brain imaging, which confirmed a space-occupying lesion. In both patients, the tumor was proven on histopathologic examination of brain tissue to be central nervous system lymphoma. Awareness of other possible underlying pathologies is warranted in cases of atypical choroidal neovascularization.
authors.affiliation: Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Shiri
authors.initials: S
authors.lastname: Zayit-Soudry
authors.forename: Anat
authors.initials: A
authors.lastname: Kesler
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tsehori
authors.forename: Leonor
authors.initials: L
authors.lastname: Leider-Trejo
authors.forename: Anat
authors.initials: A
authors.lastname: Loewenstein
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000628:therapy; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005451:Fluorescein Angiography; D006801:Humans; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor