Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone.
Polyvinyl alcohol (PVA)/sodium alginate (SA) hydrogel matrix-based wound dressing systems containing nitrofurazone (NFZ), a topical anti-infective drug, were developed using freeze-thawing method. Aqueous solutions of nitrofurazone and PVA/SA mixtures in different weight ratios were mixed homogeneously, placed in petri dishes, freezed at -20 degrees C for 18h and thawed at room temperature for 6h, for three consecutive cycles, and evaluated for swelling ratio, tensile strength, elongation and thermal stability of the hydrogel. Furthermore, the drug release from this nitrofurazone-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were performed. Increased SA concentration decreased the gelation%, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of nitrofurazone. The amounts of proteins adsorbed on hydrogel were increased with increasing sodium alginate ratio, indicating the reduced blood compatibility. In vivo experiments showed that this hydrogel improved the healing rate of artificial wounds in rats. Thus, PVA/SA hydrogel matrix based wound dressing systems containing nitrofurazone could be a novel approach in wound care.
Kim
Jong Oh
JO
Dong-A Pharm. Co. Ltd., Yongin-Si, Kyunggi-Do 449-905, South Korea.
Park
Jung Kil
JK
Kim
Jeong Hoon
JH
Jin
Sung Giu
SG
Yong
Chul Soon
CS
Li
Dong Xun
DX
Choi
Jun Young
JY
Woo
Jong Soo
JS
Yoo
Bong Kyu
BK
Lyoo
Won Seok
WS
Kim
Jung-Ae
JA
Choi
Han-Gon
HG
D000327:Adsorption; D000464:Alginates / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001458:Bandages; D001798:Blood Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D004355:Drug Stability; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels; D008297:Male; D009583:Nitrofurazone / Q000008:administration & dosage*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013696:Temperature; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
D000464:Alginates; D000890:Anti-Infective Agents; D001798:Blood Proteins; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D009583:Nitrofurazone