title: In vitro activity of telavancin against resistant gram-positive bacteria.
abstract: The in vitro activity of telavancin was tested against 743 predominantly antimicrobial-resistant, gram-positive isolates. Telavancin was highly active against methicillin-resistant staphylococci (MIC(90), 0.5 to 1 microg/ml), streptococci (all MICs, < or =0.12 microg/ml), and VanB-type enterococci (all MICs, < or =2 microg/ml). Time-kill studies demonstrated the potent bactericidal activity of telavancin.
authors.affiliation: Theravance, Inc., South San Francisco, CA 94080, USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Krause
authors.forename: Marika
authors.initials: M
authors.lastname: Renelli
authors.forename: Stacey
authors.initials: S
authors.lastname: Difuntorum
authors.forename: Terry X
authors.initials: TX
authors.lastname: Wu
authors.forename: Dmitri V
authors.initials: DV
authors.lastname: Debabov
authors.forename: Bret M
authors.initials: BM
authors.lastname: Benton
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D000077427:Lipoglycopeptides; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; C487637:telavancin