Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course.
Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.
Freer
Giulia
G
Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Via del Brennero 2, I-56127 Pisa, Italy. freer@biomed.unipi.it
Matteucci
Donatella
D
Mazzetti
Paola
P
Tarabella
Francesca
F
Ricci
Enrica
E
Bozzacco
Leonia
L
Merico
Antonio
A
Pistello
Mauro
M
Ceccherini-Nelli
Luca
L
Bendinelli
Mauro
M
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D002415:Cats; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000821:virology*; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy* / Q000821:virology; D007111:Immunity, Cellular; D016089:Immunodeficiency Virus, Feline / Q000276:immunology* / Q000502:physiology; D007167:Immunotherapy / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D019562:Viral Load; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D015164:Vaccines, Inactivated; D014765:Viral Vaccines