QSAR study of mosquito repellents from terpenoid with a six-member-ring.
A new class of low-toxicity mosquito repellents is synthesized from alpha- and beta-pinene in terpenoid compounds and preliminary biological tests show promising mosquito repellency. Statistical modeling is built using Codessa in order to reveal the quantitative relationship between the structure and the biological activity and to provide the guidance for further synthetic work.
Wang
Zongde
Z
College of Forestry, Jiangxi Agricultural University, Nanchang 330045, China.
Song
Jie
J
Chen
Jinzhu
J
Song
Zhanqian
Z
Shang
Shibin
S
Jiang
Zhikuan
Z
Han
Zhaojiu
Z
D000818:Animals; D000081008:Bicyclic Monoterpenes; D001733:Bites and Stings / Q000517:prevention & control*; D001643:Bridged Bicyclo Compounds; D009033:Culicidae / Q000187:drug effects*; D007302:Insect Repellents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008956:Models, Chemical; D039821:Monoterpenes / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D021281:Quantitative Structure-Activity Relationship
D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D007302:Insect Repellents; D039821:Monoterpenes; C010789:beta-pinene; C005451:alpha-pinene