title: Amelioration of experimental autoimmune encephalomyelitis by BLyS autovaccine.
abstract: The B-lymphocyte stimulator (BLyS) is implicated in various pathophysiological processes. The overexpression of BLyS has been observed in some human diseases, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. This feature suggests that BLyS may be a therapeutic target for some human autoimmune diseases. We developed a therapeutic vaccine by coupling a tetanus toxoid T-helper cell epitope with the C-terminal of BLyS (TT-BLyS). This vaccine can induce high titers of neutralizing antibodies against BLyS in an animal model; the antibody has markedly protective effects on experimental autoimmune encephalomyelitis in rats, which is induced by inoculation of spinal cord homogenate. Our data suggest that the BLyS autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with the production of BLyS.
authors.affiliation: Biotechnology Center of The Fourth Military Medical University, 17 Changle West Road, 710032 Xi'an, People's Republic of China.
authors.forename: Xiaochang
authors.initials: X
authors.lastname: Xue
authors.forename: Guodong
authors.initials: G
authors.lastname: Feng
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Qin
authors.forename: Shouzhen
authors.initials: S
authors.lastname: Wu
authors.forename: Cun
authors.initials: C
authors.lastname: Zhang
authors.forename: Yanjie
authors.initials: Y
authors.lastname: You
authors.forename: Weihua
authors.initials: W
authors.lastname: Wang
authors.forename: Changli
authors.initials: C
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Wenhua
authors.initials: W
authors.lastname: Zhu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ran
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D001324:Autoantigens / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D053264:B-Cell Activating Factor / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D001522:Behavior, Animal; D002531:Cerebellum / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000502:physiology; D009500:Neutralization Tests; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000473:pathology; D014612:Vaccines / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D053264:B-Cell Activating Factor; D014612:Vaccines; D014614:Vaccines, Synthetic; D007073:Immunoglobulin E; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases