title: Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer.
abstract: METHODS
  A two-center prospective case series analysis.
  
  
  METHODS
  One hundred fourteen patients with previously treated laryngeal or pharyngeal squamous cell carcinoma who underwent salvage transoral laser microsurgery (TLM).
  
  
  METHODS
  TLM in 114 patients, neck dissection in 22 (19%) patients, adjuvant radiotherapy in 12 (11%) patients.
  
  
  RESULTS
  Ninety-one (80%) patients had recurrent primary tumors whereas 23 (20%) patients had second primary tumors occur within a previously irradiated field. The minimum follow-up was 1 year (median, 3 years). The distribution of tumor location was oropharynx 52 (46%), glottic and subglottic larynx 44 (39%), supraglottic larynx 11 (10%), and pyriform/hypopharynx 7 (6%). Overall, three-year local and locoregional control estimates were 70 percent and 67 percent, respectively; and three-year survival and disease-free survival estimates were 62 percent and 64 percent, respectively. The average duration of hospitalization was 2.3 days. Four (3.5%) patients had significant postoperative bleeding. Two (<2%) patients had treatment-related deaths.
  
  
  CONCLUSIONS
  Transoral laser microsurgery offers select patients an attractive alternative salvage surgical therapy to the recurrent and second primary tumor site.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA. grant.david@mayo.edu
authors.forename: David G
authors.initials: DG
authors.lastname: Grant
authors.forename: John R
authors.initials: JR
authors.lastname: Salassa
authors.forename: Michael L
authors.initials: ML
authors.lastname: Hinni
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Pearson
authors.forename: Richard E
authors.initials: RE
authors.lastname: Hayden
authors.forename: William C
authors.initials: WC
authors.lastname: Perry
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009055:Mouth; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010610:Pharyngeal Neoplasms / Q000601:surgery*; D011446:Prospective Studies