title: Exercise therapy in juvenile idiopathic arthritis.
abstract: BACKGROUND
  Exercise therapy is considered an important component of the treatment of arthritis. The efficacy of exercise therapy has been reviewed in adults with rheumatoid arthritis but not in children with juvenile idiopathic arthritis (JIA).
  
  
  OBJECTIVE
  To assess the effects of exercise therapy on functional ability, quality of life and aerobic capacity in children with JIA.
  
  
  METHODS
  The Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (The Cochrane Library), MEDLINE (January 1966 to April 2007), CINAHL (January 1982 to April 2007), EMBASE (January 1966 to October 2007), PEDro (January 1966 to October 2007), SportDiscus (January 1966 to October 2007), Google Scholar (to October 2007), AMED (Allied and Alternative Medicine) (January 1985 to October 2007), Health Technologies Assessment database (January 1988 to October 2007), ISI Web Science Index to Scientific and Technical Proceedings (January 1966 to October 2007) and the Chartered Society of Physiotherapy website (http://www.cps.uk.org) were searched and references tracked.
  
  
  METHODS
  Randomised controlled trials (RCTs) of exercise treatment in JIA.
  
  
  METHODS
  Potentially relevant references were evaluated and all data were extracted by two review authors working independently.
  
  
  RESULTS
  Three out of 16 identified studies met the inclusion criteria, with a total of 212 participants. All the included studies fulfilled at least seven of 10 methodological criteria. The outcome data of the following measures were homogenous and were pooled in a meta-analysis: functional ability (n = 198; WMD -0.07, 95% CI -0.22 to 0.08), quality of life (CHQ-PhS: n = 115; WMD -3.96, 95% CI -8.91 to 1.00) and aerobic capacity (n = 124; WMD 0.04, 95% CI -0.11 to 0.19). The results suggest that the outcome measures all favoured the exercise therapy but none were statistically significant. None of the studies reported negative effects of the exercise therapy.
  
  
  CONCLUSIONS
  Overall, based on 'silver-level' evidence (www.cochranemsk.org) there was no clinically important or statistically significant evidence that exercise therapy can improve functional ability, quality of life, aerobic capacity or pain. The low number of available RCTs limits the generalisability. The included and excluded studies were all consistent about the adverse effects of exercise therapy; no short-term detrimental effects of exercise therapy were found in any study. Both included and excluded studies showed that exercise does not exacerbate arthritis. The large heterogeneity in outcome measures, as seen in this review, emphasises the need for a standardised assessment or a core set of functional and physical outcome measurements suited for health research to generate evidence about the possible benefits of exercise therapy for patients with JIA. Although the short-term effects look promising, the long-term effect of exercise therapy remains unclear.
authors.affiliation: University Medical Center Utrecht, Department of Pediatric Physical Therapy & Exercise Physiology, Room Kb 02.056.0, POBox 85090, Utrecht, Netherlands, 3508 AB. t.takken@umcutrecht.nl
authors.forename: T
authors.initials: T
authors.lastname: Takken
authors.forename: M
authors.initials: M
authors.lastname: van Brussel
authors.forename: R H H
authors.initials: RH
authors.lastname: Engelbert
authors.forename: J
authors.initials: J
authors.lastname: Van der Net
authors.forename: W
authors.initials: W
authors.lastname: Kuis
authors.forename: P J M
authors.initials: PJ
authors.lastname: Helders
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000534:rehabilitation*; D002648:Child; D002675:Child, Preschool; D005081:Exercise Therapy / Q000009:adverse effects; D006801:Humans; D010101:Oxygen Consumption / Q000502:physiology*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic