title: Chemistry of CpG DNA.
abstract: The vertebrate immune system can recognize specific pathogen-associated molecular patterns in invading microorganisms, including the unmethylated CpG dinucleotide. This unit discusses the receptors that recognize CpG motifs and important aspects of the sequence context of CpG motifs to the end of understanding and designing CpG DNA for therapeutic purposes.
authors.affiliation: Hybridon, Inc., Cambridge, Massachusetts, USA.
authors.forename: Ekambar R
authors.initials: ER
authors.lastname: Kandimalla
authors.forename: Sudhir
authors.initials: S
authors.lastname: Agrawal
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D018899:CpG Islands / Q000235:genetics* / Q000276:immunology; D004269:DNA, Bacterial / Q000737:chemistry* / Q000276:immunology; D007109:Immunity
chemical_list: D004269:DNA, Bacterial