[Correlation between the effect of chemotherapy on complement conformation and on CA-125 antigen in the blood plasma of patients with ovarian carcinoma].
Correlation was investigated between blood-plasma levels of C3(H2)O (conformation pattern of C3 component of the complement) and tumor-associated marker CA-125 in patients with ovarian cancer before and after chemotherapy. Since a drop in CA-125 level after chemotherapy was associated with similar changes in C3(H2)O fraction, it seems reasonable to suggest that change in conformation of C3 is a response of the immune system to cancer.
Kniazeva
O A
OA
Sakaeva
D D
DD
Kamilov
F Kh
FKh
Vakhitov
V A
VA
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D018394:CA-125 Antigen / Q000097:blood* / Q000187:drug effects*; D003176:Complement C3 / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D011487:Protein Conformation / Q000187:drug effects
D018394:CA-125 Antigen; D003176:Complement C3