[Regenerative cell therapy of the type I diabetes mellitus and its complications].
This review describes up-to-date concepts of the type I diabetes mellitus pathogenesis and its complications. The leading role of the immune system malfunction in pancreatic islet of Langerhans and in vessel wall regeneration impairment is emphasized. It is suggested, that cell therapy of the type I diabetes mellitus with pancreatic islet and bone marrow cell transplantation promote beta-cell regeneration due to normalization of intracellular interaction in these tissues and immune homeostasis in whole organism.
Zakir'ianov
A R
AR
Onishchenko
N A
NA
Klimenko
E D
ED
Pozdniakov
O M
OM
D016026:Bone Marrow Transplantation / Q000379:methods*; D048909:Diabetes Complications / Q000517:prevention & control / Q000628:therapy*; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D050417:Insulin-Secreting Cells / Q000637:transplantation*