Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports.
BACKGROUND
Non-specific abnormalities in liver function tests might accompany the clinical course of hyperthyroidism. Hyperthyroidism can cause the elevation of hepatic enzymes and bilirubin. Jaundice is rare in overt hyperthyroidism, especially in subclinical hyperthyroidism. On the other hand, the use of anti-thyroid drugs has rarely been associated with toxic hepatitis and cholestatic jaundice.


METHODS
Here we present two cases of cholestasis that accompanied two distinct forms of clinical hyperthyroidism. The first patient had a clinical presentation of severe cholestasis in the absence of congestive failure related to hyperthyroidism. The second case had developed intrahepatic cholestasis in the presence of subclinical hyperthyroidism, and improved with rifampicin treatment.


CONCLUSIONS
Hyperthyroidism should be a consideration in non-specific liver dysfunction.
Soylu
Aliye
A
Department of Gastroenterology, Dr Sadi Konuk Research Hospital, Istanbul, Turkey. aliyesoylu@superonline.com
Taskale
Mustafa Gurkan
MG
Ciltas
Aydin
A
Kalayci
Mustafa
M
Kumbasar
A Baki
AB