[The role of mitochondrial uncoupling proteins in the development of changes of endothelium-dependent reactions of the heart and vessels in experimental diabetes mellitus].
The influence of mitochondrial uncoupling protein genipin on endothelium-dependent reaction of vessels, heart contractility and myocardial oxygen consumption was studied at streptozotocin-induced rat model of diabetes mellitus. The partial restoration of damaged at diabetes mellitus vascular reactions as well as decrease ofmyocardial oxygen consumption has been shown after intraperitoneal injection of genipin. For example, after the introduction of 10 mg/kg genipin were shown a partial restoration of endothelium-dependent dilatation of aorta and coronary vessels, increase of contractive strength-dependent responses of vascular smooth muscle, decrease of portal vein isolated strips stiffness, the improvement of contractive properties and decrease of myocardial stiffness. These data suggest a possible role for mitochondrial uncoupling protein in the development of changes of heart and vascular responses observed at experimental diabetes mellitus.
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D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000502:physiology*; D057889:Iridoid Glycosides; D039823:Iridoids / Q000494:pharmacology; D008297:Male; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D000071256:Uncoupling Protein 1; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D007473:Ion Channels; D057889:Iridoid Glycosides; D039823:Iridoids; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1; C007834:genipin