[Autoantibodies to glutamate receptors and metabolic products of nitric oxide in blood serum of children in the acute period of brain trauma].
Autoantibodies (AB) to glutamate receptors of AMPA (Glur1) and NMDA (NR2A) types and nitric oxide metabolites, nitrates and nitrites (NOx), were studied in the blood serum of children with brain trauma of different severity. The level of both AB types increased from the 1st to the 10th day after trauma. The level of NMDA (NR2A) AB was higher comparing to AMPA (Glur1). Patients with mild brain trauma, scoring 14-15 on the Coma Glasgow Scale, had the highest AB concentration while patients with severe brain trauma (scores <9), had the lower level of NMDA (NR2A) AB. The lowest level of AB and the highest level of NOx in the blood serum were found in a group of children with the fatal outcome of severe brain trauma. The many-fold increase of NOx concentration in this group points to marked hypoxia after severe brain trauma.
Sorokina
E G
EG
Semenova
Zh B
ZhB
Bazarnaia
N A
NA
Meshcheriakov
S V
SV
Reutov
V P
VP
Goriunova
A V
AV
Pinelis
V G
VG
Granstrem
O K
OK
Roshal'
L M
LM
D001323:Autoantibodies / Q000097:blood*; D001930:Brain Injuries / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology*; D002648:Child; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000097:blood; D017470:Receptors, Glutamate / Q000276:immunology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D001323:Autoantibodies; D009566:Nitrates; D009573:Nitrites; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D009569:Nitric Oxide