title: Peptidomimetics, a synthetic tool of drug discovery.
abstract: The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.
authors.affiliation: Bio5 Institute, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Josef
authors.initials: J
authors.lastname: Vagner
authors.forename: Hongchang
authors.initials: H
authors.lastname: Qu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation
chemical_list: D004151:Dipeptides; D010455:Peptides