[Preparation of total matrine controlled release micropellet capsules].
OBJECTIVE
To prepare total matrine controlled release micropellet capsules.


METHODS
The capsules were prepared by the technology of film-coating with surelease as matrix, and judged by the release behavior.


RESULTS
The drug had completely been coated into a homogeneous and continuous film, and the results repeated in three batches showed that the release behavior of the pellet capsules followed zero-equation.


CONCLUSIONS
The capsules have good sustained release effect and the process of the preparation is available.
Shi
Jun
J
Department of Pharmarcy, Guangzhou University of Chinese Medicine, Guangzhou 510045, China.
Cheng
Yi
Y
Li
Xue-tao
XT
D000470:Alkaloids / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002482:Cellulose / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D008863:Microspheres; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D011807:Quinolizines / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014867:Water; D000093842:Matrines
D000470:Alkaloids; D003692:Delayed-Action Preparations; D011108:Polymers; D011807:Quinolizines; D012997:Solvents; D014867:Water; D002482:Cellulose; D000093842:Matrines