title: Analysis of prognostic factors associated with injection-site sarcomas in cats: 57 cases (2001-2007).
abstract: OBJECTIVE
  To identify prognostic factors in cats with injection-site sarcomas (ISSs).
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  57 cats with ISSs.
  
  
  METHODS
  Medical records of cats were reviewed with regard to sex, age, anatomic site of tumor, tumor size, histologic grade, excision of a primary tumor versus excision of a recurrent ISS, use of excision alone versus excision plus adjuvant therapy, local tumor recurrence, and development of distant metastasis to predict overall survival time (ie, time from tumor excision to death).
  
  
  RESULTS
  In univariate analyses, local recurrence and development of distant metastasis were significantly associated with survival time in cats. On multivariate analysis, development of distant metastasis remained a significant prognostic factor. Histologic grade was associated with distant metastasis, with cats having grade 3 tumors being significantly more likely to develop metastasis than cats with grade 1 and 2 tumors. Factors associated with local recurrence of ISSs were not identified.
  
  
  CONCLUSIONS
  The development of distant metastasis, which may occur later during the course of the disease, was identified as a prognostic factor for overall survival time in cats with ISSs. In addition, cats with histologic grade 3 ISSs should be considered for further interventional studies with chemotherapy to prevent the high rate of distant metastasis.
authors.affiliation: Clinica Veterinaria Nerviano, via Lampugnani 3, Nerviano (MI), Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Romanelli
authors.forename: Laura
authors.initials: L
authors.lastname: Marconato
authors.forename: Daniela
authors.initials: D
authors.lastname: Olivero
authors.forename: Federico
authors.initials: F
authors.lastname: Massari
authors.forename: Eric
authors.initials: E
authors.lastname: Zini
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000401:mortality* / Q000473:pathology; D002415:Cats; D005260:Female; D007267:Injections / Q000009:adverse effects / Q000662:veterinary*; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D016019:Survival Analysis