Psychotic mania associated with mefloquine in a bipolar patient.
A 63-year-old male patient with a history of bipolar I disorder presented to the emergency department in an acutely psychotic state. The patient had just returned from vacation in a malarial high-risk area and, as a result, had taken five weekly doses of mefloquine for prophylaxis. The patient's bipolar disorder was being treated with lithium, and he had been stable for about 8 years. All organic causes of psychosis were ruled out. The patient was admitted to the inpatient psychiatric unit and was treated with quetiapine until he was stable enough to return home.
Brumbaugh
Meredith
M
Pharmacy Department, Alegent Health, Immanuel Medical Center, Omaha, NE 68122, USA. mbrumbau@alegent.org
Price
Paul
P
Fagan
Nancy
N
Hsieh
Hudson
H
D000962:Antimalarials / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001714:Bipolar Disorder / Q000188:drug therapy; D000075202:Contraindications; D018450:Disease Progression; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage; D008288:Malaria / Q000517:prevention & control; D008297:Male; D015767:Mefloquine / Q000009:adverse effects*; D008875:Middle Aged
D000962:Antimalarials; D014150:Antipsychotic Agents; D018020:Lithium Compounds; D015767:Mefloquine