EJCs at the heart of translational control.
In mammalian cells, the splicing machinery deposits the exon junction complex (EJC) on mRNA splice junctions. Two studies in this issue now link the EJC to different aspects of translational control. Ma et al. (2008) show that the EJC activates translation downstream of the mTOR signaling pathway, whereas Isken et al. (2008) establish that translation is repressed by partners of the EJC that are implicated in nonsense mediated decay (NMD).
Le Hir
Hervé
H
Equipe Labelisée La Ligue, Centre de Génétique Moléculaire, CNRS UPR 2167, 91198 Gif-sur-Yvette, France.
Séraphin
Bertrand
B
D000818:Animals; D018389:Codon, Nonsense; D005091:Exons; D006801:Humans; D014176:Protein Biosynthesis; D012326:RNA Splicing; D020871:RNA Stability; D012261:Ribonucleoproteins / Q000378:metabolism*
D018389:Codon, Nonsense; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein