title: Biphenylene-substituted ruthenocenylphosphine for Suzuki-Miyaura coupling of aryl chlorides.
abstract: High activity in the palladium-catalyzed Suzuki-Miyaura reactions of aryl chlorides with arylboronic acids was furnished using biphenylene-substituted di- tert-butylruthenocenylphosphine (R-Phos) as a supporting ligand. Substrate combinations even for the construction of highly hindered tetra- ortho-substituted biaryls can be achieved in good to excellent yields with low catalyst loadings in short reaction times.
authors.affiliation: Faculty of Engineering and Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Nishi-ku, Niigata 950-2181, Japan. hoshi@gs.niigata-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hoshi
authors.forename: Taichi
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Ippei
authors.initials: I
authors.lastname: Saitoh
authors.forename: Ayako
authors.initials: A
authors.lastname: Mori
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Sakai
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Hagiwara
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001713:Biphenyl Compounds; D001897:Boronic Acids; D006571:Heterocyclic Compounds; D006843:Hydrocarbons, Chlorinated; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D010165:Palladium; D012428:Ruthenium