Carboxamides combining favorable olfactory properties with insect repellency.
By a simple methodology, we have synthesized 68 carboxamides, with structural analogy to the most efficient mosquitoes repellent DEET (N,N-diethyl-m-toluamide, 9). Eight of them have very promising olfactory profiles. In addition, 34 carboxamides have been tested for their repellency properties against three breeds of cockroach; six of them are excellent in this domain. Two of these, the 2-ethyl-N-isopropyl-N-methylbutanamide and N,N-diallyl-2-ethylbutanamide combine both the positive aspects, and are thus very good candidates for use in functional perfumery, and more particularly in home-care formulations.
Gaudin
Jean-Marc
JM
Firmenich SA, Corporate R&D Division, P.O. Box 239, CH-1211 Geneva 8. jean-marc.gaudin@firmenich.com
Lander
Thierry
T
Nikolaenko
Olga
O
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D003058:Cockroaches; D005260:Female; D007302:Insect Repellents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D009812:Odorants
D000577:Amides; D007302:Insect Repellents