Synthesis of 2'-O-beta-d-Ribofuranosylnucleosides.
A simple and efficient method for the preparation of 2-O-beta-D-ribofuranosylnucleosides, minor tRNA components, is described in this unit. The method consists of condensation of a small excess of 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose activated with tin tetrachloride with N-protected 3,5-O-tetra-isopropyldisiloxane-1,3-diyl-ribonucleosides in 1,2-dichloroethane. Subsequent deprotection produces 2-O-beta-D-ribofuranosylnucleosides in an overall yield of 46% to 72%.
Mikhailov
Sergey N
SN
Russian Academy of Sciences, Engelhardt Institute of Molecular Biology, Moscow, Russia.
Efimtseva
Ekaterina V
EV
Rodionov
Andrei A
AA
Bobkov
Georgii V
GV
Kulikova
Irina V
IV
Herdewijn
Piet
P
D002855:Chromatography, Thin Layer; D005663:Furans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D005663:Furans; D012263:Ribonucleosides