Recent developments in enantioselective gold(I) catalysis.
The use of gold(I) complexes as catalysts for organic transformations has become increasingly common over the past decade, leading to the development of a number of useful carbon-carbon and carbon-heteroatom bond-forming processes. In contrast, enantioselective catalysis employing gold(I) complexes was, until recently, exceedingly rare, due in large part to the pronounced tendency of gold(I) to form linear, two-coordinate complexes. However, new approaches and strategies have emerged over the past two years, leading to the development of a number of effective gold(I)-catalyzed enantioselective transformations, most notably the enantioselective hydrofunctionalization of allenes. Outlined herein is an overview of enantioselective gold(I) catalysis since 2005.
Widenhoefer
Ross A
RA
Department of Chemistry, Duke University, French Family Science Center, Durham, NC 27708, USA. rwidenho@chem.duke.edu
D000480:Alkynes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism
D000480:Alkynes; D002244:Carbon; D006046:Gold