title: Study protocol of the German "Registry for the detection of late sequelae after radiotherapy in childhood and adolescence" (RiSK).
abstract: BACKGROUND
  Late effects after radiotherapy in childhood and adolescence have mainly been characterized retrospectively with small patient numbers. However, these analyses are limited due to little information regarding organ dose levels in many cases. To overcome this limitation, the German Group of Paediatric Radiation Oncology (APRO) established the "Registry for the evaluation of late side effects after radiation in childhood and adolescence" (RiSK). The study protocol and the documentation forms are given in this publication.
  
  
  METHODS
  Radiation parameters including detailed organ doses as well as toxicity evaluations are collected prospectively from centres all over Germany. Standardized documentation forms are used. These forms are given in an English and German version as additional files to this publication. Documentation is planned for all children who receive radiotherapy in one of the therapy trials of the "German Society of Paediatric Oncology and Haematology (GPOH)". The study started in a pilot phase in June 2001 in few centres. Since 2004 documentation has been performed all over Germany and is still on-going.
  
  
  CONCLUSIONS
  To our knowledge, "RiSK" is the only multi-centre study that evaluates radiation associated side effects prospectively with detailed information about organ dose levels. With ongoing recruitment and prolongation of follow-up powerful data will be obtained in a few years. A broad use and international cooperation are welcome.
authors.affiliation: Department of Radiotherapy, University Hospital of Münster, Germany. Tobias.Boelling@ukmuenster.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Bolling
authors.forename: Andreas
authors.initials: A
authors.lastname: Schuck
authors.forename: Hildegard
authors.initials: H
authors.lastname: Pape
authors.forename: Christian
authors.initials: C
authors.lastname: Rube
authors.forename: Barbara
authors.initials: B
authors.lastname: Pollinger
authors.forename: Beate
authors.initials: B
authors.lastname: Timmermann
authors.forename: Rolf D
authors.initials: RD
authors.lastname: Kortmann
authors.forename: Karin
authors.initials: K
authors.lastname: Dieckmann
authors.forename: Normann
authors.initials: N
authors.lastname: Willich
mesh_terms: D000293:Adolescent; D002648:Child; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012042:Registries; D012955:Societies, Medical