title: Atrophy measurement of the anterior commissure and substantia innominata with 3T high-resolution MR imaging: does the measurement differ for patients with frontotemporal lobar degeneration and Alzheimer disease and for healthy subjects?
abstract: OBJECTIVE
  The anterior commissure (AC) and substantia innominata (SI) can be clearly demonstrated at 3T high-resolution MR imaging. Our aim was to investigate if atrophy of the AC and SI on 3T MR imaging differs among patients with frontotemporal lobar degeneration (FTLD) and Alzheimer dementia (AD) and healthy subjects.
  
  
  METHODS
  Seven consecutive patients with FTLD, 20 patients with AD, and 16 age-matched control subjects were enrolled. MR imaging was performed at 3T. The AC thickness as well as the SI thickness was measured on a thin-section coronal T2-weighted image, and the AC area was measured on a sagittal T1-weighted image. The measurement differences among the participants were analyzed with the Kruskal-Wallis test. A correlation of the measurement with the Mini-Mental State Examination (MMSE) score was obtained with the Spearman rank correlation test.
  
  
  RESULTS
  Thinning of the AC was significantly more prominent in FTLD than in AD (P < .001). Although the right SI thickness was significantly decreased in patients with AD as compared with control subjects (P < .05), there was no significant difference, with a substantial overlap of the average SI thickness among the 3 groups. The thickness and the area of the AC were positively correlated with the MMSE score (rho = 0.612, P < .001, and rho = 0.659, P < .001, respectively). In contrast, the average SI thickness showed a weak positive correlation with the MMSE score (rho = 0.325, P < .05).
  
  
  CONCLUSIONS
  Measurement of AC atrophy with 3T MR imaging may provide additional diagnostic clues for FTLD and AD. Conversely, SI atrophy measurement does not provide an additional benefit in the evaluation of FTLD and AD, owing to a considerable overlap in the average thickness of bilateral SI.
authors.affiliation: Department of Radiology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea. mdmoonwj@naver.com
authors.forename: W-J
authors.initials: WJ
authors.lastname: Moon
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: H G
authors.initials: HG
authors.lastname: Roh
authors.forename: S-H
authors.initials: SH
authors.lastname: Han
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D001284:Atrophy; D003704:Dementia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D012016:Reference Values; D012686:Septal Nuclei / Q000473:pathology*; D013377:Substantia Innominata / Q000473:pathology*