title: IDT SciTools: a suite for analysis and design of nucleic acid oligomers.
abstract: DNA and RNA oligomers are used in a myriad of diverse biological and biochemical experiments. These oligonucleotides are designed to have unique biophysical, chemical and hybridization properties. We have created an integrated set of bioinformatics tools that predict the properties of native and chemically modified nucleic acids and assist in their design. Researchers can select PCR primers, probes and antisense oligonucleotides, find the most suitable sequences for RNA interference, calculate stable secondary structures, and evaluate the potential for two sequences to interact. The latest, most accurate thermodynamic algorithms and models are implemented. This free software is available at http://www.idtdna.com/SciTools/SciTools.aspx.
authors.affiliation: Department of Molecular Genetics and Biophysics, Integrated DNA Technologies, Inc., 1710 Commercial Park, Coralville, IA 52241, USA. science@owczarzy.net
authors.forename: Richard
authors.initials: R
authors.lastname: Owczarzy
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Tataurov
authors.forename: Yihe
authors.initials: Y
authors.lastname: Wu
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Manthey
authors.forename: Kyle A
authors.initials: KA
authors.lastname: McQuisten
authors.forename: Hakeem G
authors.initials: HG
authors.lastname: Almabrazi
authors.forename: Kent F
authors.initials: KF
authors.lastname: Pedersen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.forename: Justin
authors.initials: J
authors.lastname: Garretson
authors.forename: Neil O
authors.initials: NO
authors.lastname: McEntaggart
authors.forename: Chris A
authors.initials: CA
authors.lastname: Sailor
authors.forename: Robert B
authors.initials: RB
authors.lastname: Dawson
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Peek
mesh_terms: D017931:DNA Primers / Q000737:chemistry; D020407:Internet; D009690:Nucleic Acid Conformation; D015345:Oligonucleotide Probes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry; D012984:Software
chemical_list: D017931:DNA Primers; D015345:Oligonucleotide Probes; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering; C477371:locked nucleic acid