title: Plasma exchange in a case of severe factor X deficiency in pregnancy: critical review of the literature.
abstract: Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chiossi
authors.forename: Joel A
authors.initials: JA
authors.lastname: Spero
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Esaka
authors.forename: Kristin
authors.initials: K
authors.lastname: Novic
authors.forename: Jennifer U
authors.initials: JU
authors.lastname: Celebrezze
authors.forename: Steven H
authors.initials: SH
authors.lastname: Golde
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Thomas
mesh_terms: D001946:Breech Presentation / Q000601:surgery; D002585:Cesarean Section; D005171:Factor X Deficiency / Q000628:therapy*; D005260:Female; D006801:Humans; D010951:Plasma Exchange; D006473:Postpartum Hemorrhage / Q000517:prevention & control; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*