Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach.
Randomized studies in early-maturing (P2<8 years, B2 between 8 and 9 years), low-birth weight girls (N=60) show that calorie restriction mimetic therapy with metformin for 3 years is accompanied by a strikingly leaner body composition (on average, 5.2 kg less gain of fat; 1.6 kg more gain of lean mass; P<.0001).
Ibáñez
Lourdes
L
Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, 08950 Esplugues, Barcelona, Spain. libanez@hsjdbcn.org
López-Bermejo
Abel
A
de Zegher
Francis
F
D050154:Adiposity; D001823:Body Composition; D031204:Caloric Restriction; D002648:Child; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008687:Metformin / Q000494:pharmacology; D011627:Puberty / Q000378:metabolism*
D008687:Metformin