title: Cancer of the tonsil presenting as central nervous system metastasis: A case report.
abstract: BACKGROUND
  Metastases from tonsilar cancers are uncommon, usually found in the lung and less commonly in the bone, liver, and mediastinal sites. Only approximately 20% of patients die from distant metastasis. Central nervous system (CNS) metastases usually appear later in the course of the disease, with only 1% to 2% of patients developing metastasis involving the CNS in the course of their disease. Patients seen with symptomatic CNS lesions are rare.
  
  
  RESULTS
  A case report is presented of a patient seen with signs and symptoms of CNS disease from an isolated CNS metastasis. The primary site was ultimately determined to be of tonsilar origin. The patient's treatment and outcome are discussed.
  
  
  CONCLUSIONS
  Tonsilar cancers seen with signs and symptoms of CNS disease is a rare event. The benefit of aggressive treatment of isolated CNS metastasis from head and neck cancers will likely be gained from case reports because the incidence is quite low.
authors.affiliation: Department of Radiation Oncology, The University of Alabama, Birmingham, Alabama, USA. mdobelbower@uabmc.edu
authors.forename: Michael C
authors.initials: MC
authors.lastname: Dobelbower
authors.forename: Lisle
authors.initials: L
authors.lastname: Nabell
authors.forename: James
authors.initials: J
authors.lastname: Markert
authors.forename: William
authors.initials: W
authors.lastname: Carroll
authors.forename: Nasser
authors.initials: N
authors.lastname: Said-Al-Naief
authors.forename: Ruby
authors.initials: R
authors.lastname: Meredith
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003593:Cytoplasm / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009336:Necrosis; D010296:Parietal Lobe; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed; D014067:Tonsillar Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin