title: The effect of superspreading on epidemic outbreak size distributions.
abstract: Recently, evidence has been presented to suggest that there are significant heterogeneities in the transmission of communicable diseases. Here, a stochastic simulation model of an epidemic process that allows for these heterogeneities is used to demonstrate the potentially considerable effect that heterogeneity of transmission will have on epidemic outbreak size distributions. Our simulation results agree well with approximations gained from the theory of branching processes. Outbreak size distributions have previously been used to infer basic epidemiological parameters. We show that if superspreading does occur then such distributions must be interpreted with care. The simulation results are discussed in relation to measles epidemics in isolated populations and in predominantly urban scenarios. The effect of three different disease control policies on outbreak size distributions are shown for varying levels of heterogeneity and disease control effort.
authors.affiliation: Institute for Mathematical Sciences, Imperial College London, 53 Prince's Gate, Exhibition Road, South Kensington, London SW72PG, UK. t.garske@imperial.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Garske
authors.forename: C J
authors.initials: CJ
authors.lastname: Rhodes
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission*; D004196:Disease Outbreaks / Q000517:prevention & control; D004739:England / Q000453:epidemiology; D006801:Humans; D008390:Markov Chains; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D008954:Models, Biological; D011156:Population Density; D014611:Vaccination; D014852:Wales / Q000453:epidemiology