title: Cytokine profile of Armenian patients with Familial Mediterranean fever.
abstract: OBJECTIVE
  Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.
  
  
  METHODS
  The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
  
  
  RESULTS
  In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
  
  
  CONCLUSIONS
  Inflammation in FMF involves Treg and Th17 lineages.
authors.affiliation: Group of Molecular and Cellular Immunology and Laboratory of Molecular Genetics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
authors.forename: G P
authors.initials: GP
authors.lastname: Manukyan
authors.forename: K A
authors.initials: KA
authors.lastname: Ghazaryan
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Ktsoyan
authors.forename: M V
authors.initials: MV
authors.lastname: Tatyan
authors.forename: Z A
authors.initials: ZA
authors.lastname: Khachatryan
authors.forename: G S
authors.initials: GS
authors.lastname: Hakobyan
authors.forename: V A
authors.initials: VA
authors.lastname: Mkrtchyan
authors.forename: D
authors.initials: D
authors.lastname: Kelly
authors.forename: A
authors.initials: A
authors.lastname: Coutts
authors.forename: R I
authors.initials: RI
authors.lastname: Aminov
mesh_terms: D001136:Armenia; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D010505:Familial Mediterranean Fever / Q000097:blood*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000097:blood; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein