Osteopoietic stem cells: transplantable, but regeneratively limited.
Questions about the transplantability of mesenchymal stem cells, their ability to engraft within the bone marrow of recipients, and hence their clinical usefulness have been hotly debated for several decades. In this issue of Blood, Dominici and colleagues demonstrate robust serial osteopoietic engraftment, but highlight that osteopoietic chimerism declines to negligible levels after 6 months.
Nilsson
Susie
S
Australian Stem Cell Centre.