Beam me up Scotty: incorporating transporters in physiologically based pharmacokinetic-pharmacodynamic modeling.
Lehman-McKeeman
Lois D
LD
Department of Discovery Toxicology, Bristol-Myers Squibb Co., Route 206, Province Line Road, Princeton, New Jersey 08543, USA. lois.lehman-mckeeman@bms.com
D000818:Animals; D004785:Environmental Pollutants / Q000493:pharmacokinetics*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*
D004785:Environmental Pollutants; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl