Fournier's gangrene and scrotal ulcerations during all-trans-retinoic acid therapy for acute promyelocytic leukemia.
Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen in Asian population. A good outcome with supportive management occurred in all the cases.
Naithani
Rahul
R
Department of Hematology, All India Institute of Medical Sciences, New Delhi, India. dr_rahul6@hotmail.com
Kumar
Rajat
R
Mahapatra
M
M
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018934:Fournier Gangrene / Q000139:chemically induced*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D012611:Scrotum / Q000473:pathology*; D014212:Tretinoin / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced*
D000970:Antineoplastic Agents; D014212:Tretinoin