Lexical acquisition in progressive aphasia and frontotemporal dementia.
We investigated the characteristics of language difficulty in frontotemporal dementia (FTD) by exposing these patients to a new verb in a naturalistic manner and then assessing acquisition of the grammatical, semantic, and thematic matrix information associated with the new word. We found that FTD patients have difficulty relative to healthy seniors in their acquisition of the new verb, but that progressive nonfluent aphasia (PNFA), semantic dementia (SD), and social/dysexecutive variant (SOC/EXEC) subgroups of FTD demonstrate relatively distinct impairment profiles. Specifically, PNFA patients showed relative difficulty assigning the new verb to its correct grammatical form class, reflecting compromised processing of the associated grammatical information. SD patients were impaired at associating the new word with its pictorial representation, suggesting impaired processing of the new verb's semantic attributes. SOC/EXEC patients showed their greatest difficulty judging violations of the new word's associated thematic roles, implying that limited executive resources underlie in part the difficulty in integrating grammatical and semantic information into a coherent thematic matrix. Similar impairment profiles were seen during a follow-up session one week after the initial evaluation. These deficits in lexical acquisition reflect the breakdown of a language-processing system that consists of highly interactive but partially dissociable grammatical, semantic, and resource-based components, leading to relatively distinct language-processing deficits in each subgroup of patients with FTD.
Murray
Ryan
R
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.
Koenig
Phyllis
P
Antani
Shweta
S
McCawley
Gwyneth
G
Grossman
Murray
M
D000368:Aged; D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D003704:Dementia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012660:Semantics; D012720:Severity of Illness Index; D014706:Verbal Learning; D014825:Vocabulary