title: [Acute injury of inhalable particle matters on nasal mucous membrane of rat].
abstract: OBJECTIVE
  To study the mechanism of the nasal mucous membrane inflammation induced by the inhalable particle matter (PM10).
  
  
  METHODS
  Three dosage PM10 were instilled in rat nasal cavity of different groups for one week. The morphology of nasal mucosa and the numbers of inflammatory cell were observed in each samples.
  
  
  RESULTS
  The total numbers of inflammatory cells in PM10-treated groups were increased in a dose-respondent manner and significantly different from that in control group. The results of histopathological and scanning electron microscope (SEM) analysis indicated that PM10 caused nasal mucosa injury and pathological changes, such as the damage of cilia and nasal mucosa epithelium in a dose dependent way. The infiltration of inflammatory cells in nasal mucosa epithelium matrix, especially eosinophilia were observed.
  
  
  CONCLUSIONS
  PM10 can cause rat's nasal mucosa inflammation and epithelial injury.
authors.affiliation: Department of Otorhinolaryngology, Pepole's Hospital of Beijing University, Beijing, 100044, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Liu
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xing
authors.forename: Lisheng
authors.initials: L
authors.lastname: Yu
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Dong
authors.forename: Furong
authors.initials: F
authors.lastname: Deng
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D001239:Inhalation; D008297:Male; D008855:Microscopy, Electron, Scanning; D009297:Nasal Mucosa / Q000473:pathology* / Q000648:ultrastructure; D052638:Particulate Matter / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter