The natural history of type 1A diabetes.
We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.
Eisenbarth
George S
GS
Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA. george.eisenbarth@uchsc.edu
Jeffrey
Joy
J
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007328:Insulin / Q000276:immunology / Q000378:metabolism; D007330:Insulin Antibodies / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D007328:Insulin; D007330:Insulin Antibodies