title: Allergic profiles in unilateral nasal polyps of bilateral chronic rhinosinusitis.
abstract: BACKGROUND
  Bilateral chronic rhinosinusitis (CRS), with unilateral nasal polyps (NPs), is a good model for study, being characterized by a similar inflammatory reaction and environment in both nasal cavities of a subject, although NPs exist in only one nasal cavity. It may be feasible to identify specific pathological factors responsible for the disparities by comparing the differences between the nasal cavities.
  
  
  METHODS
  In patients with bilateral CRS, polyp tissue and the middle turbinate tissue on the side of the polyp were examined and compared with contralateral nonpolyp middle turbinate tissue. Tissue and serum-specific immunoglobulin E (sIgE) levels were measured, and eosinophilic infiltration, interleukin (IL)-5 and IL-1-beta were assessed also in the polyp tissue.
  
  
  RESULTS
  The presence of allergic symptoms correlated well with a positive serum CAP test but poorly with a positive tissue CAP test. There were no obvious differences between tissue sIgE levels on the NP side compared with the nonpolyp side. Tissue eosinophilia was a general characteristic of NPs, whether there was allergy or not. IL-5 and IL-1-beta levels were elevated in NPs, regardless of allergy. There were no differences in the specimens on the nonpolyp side between allergy and nonallergy groups.
  
  
  CONCLUSIONS
  With this model, we have more precise, however, not new results. Localized allergic reaction is not a major factor for the development of a unilateral polyp. Inflammation associated with eosinophilic infiltration and the presence of proinflammatory cytokines, including IL-5 and IL-1-beta, are more important in the pathogenesis of NPs than the allergic reaction.
authors.affiliation: Department of Otolaryngology, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China.
authors.forename: Jian-Yuan
authors.initials: JY
authors.lastname: Li
authors.forename: Sheen-Yie
authors.initials: SY
authors.lastname: Fang
mesh_terms: D002908:Chronic Disease; D004802:Eosinophilia / Q000097:blood; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D008297:Male; D009298:Nasal Polyps / Q000097:blood / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000276:immunology*; D012852:Sinusitis / Q000097:blood / Q000276:immunology*
chemical_list: D053583:Interleukin-1beta; D015848:Interleukin-5; D007073:Immunoglobulin E