Joint effects of antibody to heat shock protein 60, hypertension, and diabetes on risk of coronary heart disease in Chinese.
BACKGROUND
Several studies have suggested an association between antibody to human heat shock protein 60 (anti-Hsp60) and coronary atherosclerosis, but the results have been inconsistent. The aim of this study was to investigate the association between anti-Hsp60 and coronary heart disease (CHD) and to determine whether anti-Hsp60, hypertension, and diabetes have joint effects on CHD risk.


METHODS
We measured the concentrations of anti-Hsp60 in 1003 CHD patients and 1003 age- and sex-matched control subjects without CHD events.


RESULTS
Concentrations of anti-Hsp60 were significantly higher in CHD patients than in controls. Increasing concentrations of anti-Hsp60 were significantly associated with higher risk of CHD (P for trend <0.0001) and with increasing severity of CHD as assessed by number of diseased vessels detected with angiography [odds ratio (OR) 3.67, 95% CI 1.56-8.64, P = 0.003] after multivariate adjustment for traditional CHD risk factors. There were strong joint effects of high concentrations of anti-Hsp60 and hypertension (OR 5.17, 95% CI 3.95-6.75, P < 0.0001) and diabetes (OR 6.49, 95% CI 4.52-9.33, P < 0.0001) on CHD risk; simultaneous occurrence of high anti-Hsp60 concentrations, hypertension, and diabetes conferred a dramatically higher risk of CHD (OR 20.99, 95% CI 12.50-35.24, P < 0.0001) in multivariate analyses.


CONCLUSIONS
Anti-Hsp60 is independently associated with CHD risk, and a combination of high anti-Hsp60, hypertension, and diabetes is particularly detrimental for CHD risk.
Zhang
Xiaomin
X
Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
He
Mei-An
MA
Cheng
Longxian
L
Zhou
Li
L
Zeng
Hesong
H
Wang
Jing
J
Wang
Feng
F
Chen
Ying
Y
Hu
Frank B
FB
Wu
Tangchun
T
D000328:Adult; D000368:Aged; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D018834:Chaperonin 60 / Q000276:immunology*; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000208:ethnology* / Q000209:etiology / Q000276:immunology; D003920:Diabetes Mellitus / Q000208:ethnology / Q000276:immunology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000208:ethnology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012306:Risk
D001323:Autoantibodies; D018834:Chaperonin 60