title: Immunophenotype in chronic myelomonocytic leukemia: is it closer to myelodysplastic syndromes or to myeloproliferative disorders?
abstract: Chronic myelomonocytic leukemia (CMML) is a heterogeneous disease balanced between myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD). We used flow cytometry to describe and compare the immunophenotypic profile of 20 patients with CMML, 38 patients with MDS, and 20 patients with MPD. CMML and MDS only showed statistically significant differences (P<0.05) in CD56 monocyte expression. CMML and MPD showed significant differences in CD45 myeloid distribution, myeloid antigenic profile, CD56 and CD2 monocyte expression, and B-cell development. These data support the classic concept of CMML as part of MDS diseases and encourage including immunophenotyping among the studies to be performed in these diseases.
authors.affiliation: Department of Hematology, Fundación Jiménez Díaz, Madrid, Spain. dosuperez@yahoo.es
authors.forename: Dolores
authors.initials: D
authors.lastname: Subirá
authors.forename: Patricia
authors.initials: P
authors.lastname: Font
authors.forename: Lucia
authors.initials: L
authors.lastname: Villalón
authors.forename: Cristina
authors.initials: C
authors.lastname: Serrano
authors.forename: Elham
authors.initials: E
authors.lastname: Askari
authors.forename: Elena
authors.initials: E
authors.lastname: Góngora
authors.forename: Susana
authors.initials: S
authors.lastname: Castañón
authors.forename: Raquel
authors.initials: R
authors.lastname: Gonzalo
authors.forename: Raquel
authors.initials: R
authors.lastname: Mata
authors.forename: Alejandro
authors.initials: A
authors.lastname: Román
authors.forename: Pilar
authors.initials: P
authors.lastname: Llamas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000276:immunology / Q000473:pathology; D018801:CD2 Antigens / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping / Q000379:methods*; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis* / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000276:immunology; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000276:immunology
chemical_list: D018801:CD2 Antigens; D019002:CD56 Antigen; D017493:Leukocyte Common Antigens