Proinflammatory cytokines in cerebrospinal fluid from patients with nontyphoidal Salmonella encephalopathy.
Nontyphoidal Salmonella (NTS) encephalopathy is characterized by rapidly progressive brain dysfunction that develops after NTS enteritis. The mechanism of central nervous system involvement remains unclear. We examined cerebrospinal fluids from 7 patients for cytokines and found elevated interleukin-6, interleukin-8, and monocyte chemotactic protein-1 concentrations in all the patients, suggesting that the proinflammatory cytokines are involved in the pathogenesis of NTS encephalopathy.
Imamura
Mari
M
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima Seikyo Hospital, Kagoshima, Japan.
Nishi
Junichiro
J
Tamada
Izumi
I
Tenokuchi
Yoichi
Y
Toyoshima
Mitsuo
M
Kawano
Yoshifumi
Y
D001927:Brain Diseases / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000134:cerebrospinal fluid*; D004751:Enteritis / Q000150:complications*; D006801:Humans; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D012480:Salmonella Infections / Q000150:complications*
D018932:Chemokine CCL2; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8