Histone deacetylases as transducers and targets of nuclear signaling.
Histone deacetylase (HDAC) activity was first discovered about 40 years ago, but it was not until the molecular identification of the first HDACs in 1996 that this family of enzymes gained prominence. In addition to histones, HDACs reverse lysine acetylation of various non-histone proteins located in the nucleus and the cytoplasm. Here, we examine the nuclear roles of these enzymes, with a specific focus on their active crosstalk with different chromatin regulators.
Walkinshaw
Donald R
DR
Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1.
Tahmasebi
Soroush
S
Bertos
Nicholas R
NR
Yang
Xiang-Jiao
XJ
D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D016678:Genome / Q000235:genetics; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D021122:Protein Subunits / Q000378:metabolism; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism
D021122:Protein Subunits; D037761:Sirtuins; D006655:Histone Deacetylases