Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.
Zhou
Yuefen
Y
Anadys Pharmaceuticals, Inc., San Diego, USA.
Chow
Chun
C
Murphy
Douglas E
DE
Sun
Zhongxiang
Z
Bertolini
Thomas
T
Froelich
Jamie M
JM
Webber
Stephen E
SE
Hermann
Thomas
T
Wall
Daniel
D
D000617:Aminoglycosides / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D003959:Diamines / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003959:Diamines; D010880:Piperidines