title: [Familial trigeminal neuralgia].
abstract: Trigeminal neuralgia in its classic form is usually an isolated disease that occurs in sporadic fashion, but familial cases have been described. We report the case of a 45-year-old man who presented with left V2 trigeminal neuralgia. The neurological examination was normal and imaging and laboratory investigations were non-contributive to the etiological work-up. Carbamazepine gave excellent symptomatic relief. During patient evaluation, we became aware of a clustering of trigeminal neuralgia in four other family members over three generations. Familial trigeminal neuralgia has been expounded on in fewer than 30 reports in the literature. Our cases and the literature review suggest an autosomal dominant transmission. The clinical features of familial trigeminal neuralgia are described and pathophysiological implications of this genetic clustering discussed.
authors.affiliation: Service de neurologie, hôpital Al Kortobi, B.P. 90000, Tanger, Morocco. hichamotmani@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: El Otmani
authors.forename: F
authors.initials: F
authors.lastname: Moutaouakil
authors.forename: H
authors.initials: H
authors.lastname: Fadel
authors.forename: I
authors.initials: I
authors.lastname: Slassi
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010375:Pedigree; D014277:Trigeminal Neuralgia / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine