title: Umbilical port-site complications in laparoscopic cholecystectomy: role of topical antibiotic therapy.
abstract: OBJECTIVE
  Umbilical port-site infections after video-laparoscopic cholecystectomy (VLC) are frequent complications. The aim of this prospective randomized study was to verify the validity of topical rifamycin for prevention of post-VLC umbilical infections.
  
  
  METHODS
  From September 2006 to April 2007, 48 patients with uncomplicated cholelithiasis who underwent VLC were enrolled in the study. Enrolled patients were randomized into 2 groups. The first group of 24 patients was treated with topical rifamycin to the umbilicus. The second group of 24 patients was not treated with rifamycin.
  
  
  RESULTS
  Postoperative umbilical pain with a need for analgesics, presence of signs of inflammation of the umbilical wound, dehiscence of the umbilical skin sutures, and the presence of incisional umbilical hernia on the 60th postoperative day were statistically significantly better in the rifamycin group compared with the control group.
  
  
  CONCLUSIONS
  Topical administration of rifamycin to the umbilicus in the pre-, intra- and postoperative periods was a rapid, safe, and economic way to reduce infective complications after VLC.
authors.affiliation: University of Foggia, Department of Surgical Sciences, Division of General Surgery, Polyclinic Ospedali Riuniti, Foggia, Italy. tizpv@tiscali.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Neri
authors.forename: Alberto
authors.initials: A
authors.lastname: Fersini
authors.forename: Antonio
authors.initials: A
authors.lastname: Ambrosi
authors.forename: Nicola
authors.initials: N
authors.lastname: Tartaglia
authors.forename: Tiziano Pio
authors.initials: TP
authors.lastname: Valentino
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000379:methods; D002769:Cholelithiasis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012294:Rifamycins / Q000008:administration & dosage*; D013525:Surgical Instruments; D013530:Surgical Wound Infection / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014472:Umbilicus; D020535:Video-Assisted Surgery
chemical_list: D000900:Anti-Bacterial Agents; D012294:Rifamycins