OLGA gastritis staging in young adults and country-specific gastric cancer risk.
Geographical differences have been shown in the clinical outcomes of Helicobacter pylori-associated gastritis phenotypes and in gastric cancer risk. This study tested whether the Operative Link on Gastritis Assessment (OLGA) staging correlated with gastric cancer risk in populations from 3 continents. Mapped gastric biopsies were obtained from 316 dyspeptic adults aged less than 41 years from 8 geographic areas that differed in gastric cancer risk. Gastric atrophy was assessed according to internationally validated criteria. Gastritis stage was established according to the OLGA staging system. The most prevalent gastritis stages were 0 to II, which included all subjects entered from Chile, Germany, India, Italy, and Thailand. Gastritis Stages III and IV were limited to the Chinese and Korean populations. Indians had a high prevalence of H pylori infection without high-stage gastritis. In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients.
Rugge
Massimo
M
Department of Medical Diagnostic Sciences & Special Therapies-II Pathology Unit, University of Padova, Italy.
Kim
Jong G
JG
Mahachai
Varocha
V
Miehlke
Stephan
S
Pennelli
Gianmaria
G
Russo
Valentina M
VM
Perng
Chin-Lin
CL
Chang
Full-Young
FY
Tandon
Rakesh K
RK
Singal
Dinesh K
DK
Sung
Joseph J Y
JJ
Valenzuela
Jorge E
JE
Realdi
Giuseppe
G
Dore
Maria P
MP
Graham
David Y
DY
D000293:Adolescent; D000328:Adult; D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D001284:Atrophy; D001706:Biopsy; D002908:Chronic Disease; D005060:Europe / Q000453:epidemiology; D005756:Gastritis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007391:International Cooperation; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D012307:Risk Factors; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000382:microbiology