[Advance of research on SDF-1/CXCR4 axis and angiogenesis in leukemia--review].
The study on biological effects of SDF-1/CXCR4 axis composed of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 is progressing rapidly in the recent years. The SDF-1/CXCR4 axis plays an important role in occurrence and development of tumors and closely correlate with angiogenesis of tumors. This review focuses the progress of study on SDF-1/CXCR4 axis and angiogenesis in leukemia including SDF-1/ and its receptor CXCR4, the expression of SDF-1/CXCR4 axis in leukemic cells, the mechanism of relation between SDF-1/CXCR4 axis and angiogenesis in leukemia, the application of inhibitors against SDF-1/CXCR4 in treatment of angiogenesis and so on.
Bao
Cui-Hua
CH
Department of Hematology, The First Affiliated Hospital, Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China.
He
Qi-Tu
QT
D054377:Chemokine CXCL12 / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D019718:Receptors, CXCR4 / Q000378:metabolism* / Q000502:physiology
D054377:Chemokine CXCL12; D019718:Receptors, CXCR4