[The effect of mexidol on the myelosuppressive toxicity, and on the antitumor and antimetastatic effectiveness of cyclophosphane].
Mexidol therapy inhibited cyclophosphamide-induced myelosuppression in C57B1/6 line mice with Lewis lung carcinoma without affecting antitumor action of the latter. Mexidol plus cyclophosphamide proved more effective in prophylaxis of metastasis as compared with the cytostatic alone.
Siprov
A V
AV
Inchina
V I
VI
Kinzirskiĭ
A S
AS
Kinzirskaia
Iu A
IuA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects*; D018827:Carcinoma, Lewis Lung / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006454:Hemoglobins / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D019653:Myeloablative Agonists / Q000009:adverse effects / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D010847:Picolines / Q000494:pharmacology*
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D006454:Hemoglobins; D019653:Myeloablative Agonists; D010847:Picolines; C070020:emoxypine succinate; D003520:Cyclophosphamide