title: [Effects of intranasal budesonide on the expression of c-fos and c-myc in nasal polyps].
abstract: OBJECTIVE
  To investigate the effect of intranasal glucocorticoids treatment on the expression of c-fos and c-myc nasal polyps.
  
  
  METHODS
  Immunohistochemistry method was used to determine c-fos and c-myc expression in nasal polyps from patients with topical steroids treatment for 10-12 weeks and untreated patients.
  
  
  RESULTS
  The rate of c-fos expressing cases was 15% and the rate of c-myc expressing cases was 20% in nasal polyps from topical steroid treated patients, but in untreated patients, the rate of c-fos expressing cases was 80% and the rate of c-myc expressing cases was 85%. There were significant differences between two groups (P < 0.01). The c-fos and c-myc expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients.
  
  
  CONCLUSIONS
  The results show that glucocorticoids may induce cell apoptosis in nasal polyps by depressing the c-fos and c-myc expression.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Fuzhou General Hospital of Nanjing Command of the PLA, Fuzhou, 350025, China. linh96@163.com
authors.forename: Hai
authors.initials: H
authors.lastname: Lin
authors.forename: Xianming
authors.initials: X
authors.lastname: Chen
authors.forename: Zenian
authors.initials: Z
authors.lastname: Zhen
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Yu
authors.forename: Xisheng
authors.initials: X
authors.lastname: Xiong
mesh_terms: D000328:Adult; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000188:drug therapy / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D019819:Budesonide