Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata.
High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC 50 values of 23 and 19 microM, respectively.
Carroll
Anthony R
AR
Eskitis Institute, Griffith University, Brisbane, Queensland, Australia.
Urban
Sylvia
S
Lamb
Jasmine
J
Moni
Roger
R
Guymer
Gordon P
GP
Forster
Paul I
PI
Quinn
Ronald J
RJ
D000818:Animals; D035264:Flowers / Q000737:chemistry; D027822:Myrtaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011793:Queensland; D051381:Rats; D018025:Receptors, Thyrotropin-Releasing Hormone / Q000819:agonists*
D018025:Receptors, Thyrotropin-Releasing Hormone; C530183:corymbone A; C530184:corymbone B; D010696:Phloroglucinol