title: Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides.
abstract: On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H(37)Rv in BACTEC 12B medium, using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, all those with disubstituted amide structure accompanied by one or two heteroatom(s) with loan pair(s) of electrons atom(s) beta to the amide nitrogen demonstrated moderate anti-tuberculosis activity and all the monosubstituted amides showed no activity at all.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Science, Kerman, Iran.
authors.forename: Fereidoon
authors.initials: F
authors.lastname: Daryaee
authors.forename: Farzad
authors.initials: F
authors.lastname: Kobarfard
authors.forename: Ali
authors.initials: A
authors.lastname: Khalaj
authors.forename: Parisa
authors.initials: P
authors.lastname: Farnia
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006016:Glycolates / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D006016:Glycolates; C053956:glycolamide