Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.
Barluenga
Sofia
S
Institut de Science et d'Ingénierie Supramoleculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000 Strasbourg, France.
Wang
Cuihua
C
Fontaine
Jean-Gonzague
JG
Aouadi
Kaïss
K
Beebe
Kristin
K
Tsutsumi
Shinji
S
Neckers
Len
L
Winssinger
Nicolas
N
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D016227:Benzoquinones / Q000737:chemistry; D001943:Breast Neoplasms / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D047029:Lactams, Macrocyclic / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry*; D051379:Mice; D008815:Mice, Inbred Strains; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D018942:Macrolides; D054852:Small Molecule Libraries; C502130:pochonin D; C112765:tanespimycin; C035359:monorden; C001277:geldanamycin