title: Chemoselective functionalization of 3,3'-substituted BINOL derivatives.
abstract: An efficient chemoselective differentiation of vicinal phenolic and benzylic alcohols on optically active binaphthyl skeletons has been achieved via TBS protection of the less sterically hindered, external 3,3' benzylic positions. Further manipulation of functionalities either in the 2,2' or 3,3' positions is then easily achieved in high yields via the use of BOC protecting groups, functioning orthogonally to TBS.
authors.affiliation: Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, Pavia, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Coluccini
authors.forename: Antonio
authors.initials: A
authors.lastname: Castelluccio
authors.forename: Dario
authors.initials: D
authors.lastname: Pasini