Granulocyte-colony stimulating factor for the treatment of ritodrine-induced neutropenia.
We report on three pregnant women with ritodrine-induced neutropenia who were successfully treated with granulocyte-colony stimulating factor (G-CSF). The neutropenia occurred after continuous intravenous infusion of ritodrine for preterm labor. Ritodrine was discontinued and G-CSF was administered. Neutrophil counts returned to normal an average of 4.3 days after the administration. No infectious morbidity or adverse side-effects occurred in the mothers or infants. G-CSF is one possible treatment in women with ritodrine-induced neutropenia.
Kikkawa
Masashi
M
Department of Obstetrics, Gynecology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Matsubara
Shigeki
S
Takatoku
Masaaki
M
Kuwata
Tomoyuki
T
Ohkuchi
Akihide
A
Izumi
Akio
A
Watanabe
Takashi
T
Suzuki
Mitsuaki
M
D000328:Adult; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D009503:Neutropenia / Q000139:chemically induced* / Q000188:drug therapy*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D012312:Ritodrine / Q000009:adverse effects* / Q000627:therapeutic use; D015149:Tocolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use
D015149:Tocolytic Agents; D016179:Granulocyte Colony-Stimulating Factor; D012312:Ritodrine