A TRIFfic perspective on acute lung injury.
Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.
Martin
Thomas R
TR
The Medical Research Service of the VA Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98108, USA. trmartin@u.washington.edu
Wurfel
Mark M
MM
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism*; D000818:Animals; D006801:Humans; D051379:Mice; D018384:Oxidative Stress; D010743:Phospholipids / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
D033942:Adaptor Proteins, Vesicular Transport; D010743:Phospholipids; D051197:Toll-Like Receptor 4