title: OLGA gastritis staging in young adults and country-specific gastric cancer risk.
abstract: Geographical differences have been shown in the clinical outcomes of Helicobacter pylori-associated gastritis phenotypes and in gastric cancer risk. This study tested whether the Operative Link on Gastritis Assessment (OLGA) staging correlated with gastric cancer risk in populations from 3 continents. Mapped gastric biopsies were obtained from 316 dyspeptic adults aged less than 41 years from 8 geographic areas that differed in gastric cancer risk. Gastric atrophy was assessed according to internationally validated criteria. Gastritis stage was established according to the OLGA staging system. The most prevalent gastritis stages were 0 to II, which included all subjects entered from Chile, Germany, India, Italy, and Thailand. Gastritis Stages III and IV were limited to the Chinese and Korean populations. Indians had a high prevalence of H pylori infection without high-stage gastritis. In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients.
authors.affiliation: Department of Medical Diagnostic Sciences & Special Therapies-II Pathology Unit, University of Padova, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Rugge
authors.forename: Jong G
authors.initials: JG
authors.lastname: Kim
authors.forename: Varocha
authors.initials: V
authors.lastname: Mahachai
authors.forename: Stephan
authors.initials: S
authors.lastname: Miehlke
authors.forename: Gianmaria
authors.initials: G
authors.lastname: Pennelli
authors.forename: Valentina M
authors.initials: VM
authors.lastname: Russo
authors.forename: Chin-Lin
authors.initials: CL
authors.lastname: Perng
authors.forename: Full-Young
authors.initials: FY
authors.lastname: Chang
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Tandon
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Singal
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Valenzuela
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Realdi
authors.forename: Maria P
authors.initials: MP
authors.lastname: Dore
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
mesh_terms: D000293:Adolescent; D000328:Adult; D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D001284:Atrophy; D001706:Biopsy; D002908:Chronic Disease; D005060:Europe / Q000453:epidemiology; D005756:Gastritis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007391:International Cooperation; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D012307:Risk Factors; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000382:microbiology