Hepatoprotective and antioxidant activity of methanol extract of Ficus glomerata.
The present study was carried out to evaluate Ficus glomerata extracts for antioxidant and hepatoprotective properties. The methanol extract of the bark of F. glomerata showed potent in vitro antioxidant activity when compared to the root methanol extract. In the in vivo studies, the CCl(4) treated control rats showed a significant alteration in the levels of antioxidant and hepatoprotective parameters. The methanol extract of the bark when given orally along with CCl(4) at the doses of 250 and 500 mg/kg body weight showed a significant reversal of these biochemical changes towards the normal when compared to CCl(4)-treated control rats in serum, liver and kidney. The results were comparable to those observed for standard sylimarin. Histological studies also confirmed the same. The results indicated the potent hepatoprotective and antioxidant nature of the bark extract.
Channabasavaraj
Kubsad Parameshwarappa
KP
Badami
Shrishailappa
S
Bhojraj
Suresh
S
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D005260:Female; D030681:Ficus / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D000432:Methanol / Q000737:chemistry; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology
D000975:Antioxidants; D010936:Plant Extracts; D012838:Silymarin; D000432:Methanol