title: The beneficial effects of argon plasma coagulation in the management of different types of gastric vascular ectasia lesions in patients admitted for GI hemorrhage.
abstract: BACKGROUND
  Despite different forms of treatment, few studies have been performed on the outcome and prognosis of patients admitted to the hospital because of gastric vascular ectasia (GVE) and upper-GI bleeding (UGIB). There is also little knowledge on the efficacy of argon plasma coagulation (APC) in different subgroups of GVE lesions.
  
  
  OBJECTIVE
  This study was designed to evaluate the efficacy of APC in patients admitted to the hospital with UGIB because of GVE.
  
  
  METHODS
  Prospective evaluation of consecutive cases of UGIB because of GVE.
  
  
  METHODS
  Tertiary and university-affiliated hospital.
  
  
  METHODS
  Twenty-nine patients were included and divided into 3 subgroups: focal vascular ectasia lesions (FVE) (n = 10), portal hypertensive gastropathy (PHG) (n = 11), and gastric antral vascular ectasia (GAVE) (n = 8). Patients were followed at 3 months and every 6 months thereafter during a mean of 23.1 months (range 18-37 months). All patients received intensive APC treatment that was repeated, depending on the endoscopic appearance or clinical evaluation.
  
  
  RESULTS
  The overall success of APC treatment was 86%, with only one recurrence of UGIB during the follow-up period. The number of APC sessions was 1.2, 2.2, and 2.3, in each subgroup (not significant), with a total number of sessions of 1.9 +/- 1.3. Treatment success was 90% in the FVE group, 81% in the PHG group, and 87.5% in the GAVE group (NS). The rise in hematocrit from baseline values in the overall group and in each subgroup was significant (P > .01).
  
  
  CONCLUSIONS
  A single-center study and small sample.
  
  
  CONCLUSIONS
  Endoscopic thermal ablation with APC is effective in managing UGIB and in reducing transfusion requirements in patients admitted for GI hemorrhage because of different endoscopic types of GVE.
authors.affiliation: Endoscopy Unit, Institut de Malalties Digestives i Metabòliques, Hospital Clinic, University of Barcelona, Catalonia, Spain.
authors.forename: Samuel
authors.initials: S
authors.lastname: Herrera
authors.forename: Josep M
authors.initials: JM
authors.lastname: Bordas
authors.forename: Josep
authors.initials: J
authors.lastname: Llach
authors.forename: Angels
authors.initials: A
authors.lastname: Ginès
authors.forename: Maria
authors.initials: M
authors.lastname: Pellisé
authors.forename: Glòria
authors.initials: G
authors.lastname: Fernández-Esparrach
authors.forename: Fernando
authors.initials: F
authors.lastname: Mondelo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mata
authors.forename: Andres
authors.initials: A
authors.lastname: Cárdenas
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001128:Argon / Q000627:therapeutic use; D004502:Education, Medical, Continuing; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D020252:Gastric Antral Vascular Ectasia / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005753:Gastric Mucosa / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005773:Gastroscopy; D006801:Humans; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013030:Spain; D016896:Treatment Outcome
chemical_list: D001128:Argon