title: Biomaterial-loaded allograft threaded cage for the treatment of femoral head osteonecrosis in a goat model.
abstract: The purpose of this study was to evaluate the efficacy of core decompression with a biomaterial-loaded allograft threaded cage (ATC) for the treatment of femoral head osteonecrosis in an established goat model. First, bilateral early-stage osteonecrosis was induced. After core decompression, the remaining goats were randomly divided into three groups: Group A, the goats were left without any treatment; Group B, the goats were treated with implanting a composite of autologous bone and decalcified bone matrix (DBM); Group C, the goats were treated using insertion of ATC loaded with DBM and autogenous bone graft. Then radiographic, histological and biomechanical analysis were taken in each group at 5, 10, and 20 weeks postoperation. In Group A, the classical signs of osteonecrosis of the femoral head were identified 10 weeks after the induction. Twenty weeks later, the density, surface and biomechanical stability of the femoral head were normal in Group C, while an irregular surface and an inhomogeneous microstructure or variation of density/hardness were identified in Group B. The specimens revealed a continuous trabaecular bone structure throughout the cage and extensive bone ingrowth and remodeling in Group C, while fibrous tissue was evident in Group B. Core decompression with a biomaterial loaded ATC almost uniformly delays or arrests the progression of the disease before articular collapse, and it could help to get the balance between bone resorption and new bone formation, strengthen structural mechanics of the femoral head, provide structure support of articular cartilage.
authors.affiliation: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. shuhua196@yahoo.com.cn
authors.forename: Shuhua
authors.initials: S
authors.lastname: Yang
authors.forename: Xinghuo
authors.initials: X
authors.lastname: Wu
authors.forename: Rongcheng
authors.initials: R
authors.lastname: Mei
authors.forename: Cao
authors.initials: C
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Weihua
authors.initials: W
authors.lastname: Xu
authors.forename: Shunan
authors.initials: S
authors.lastname: Ye
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes; D016025:Bone Transplantation; D019299:Decompression, Surgical / Q000379:methods*; D004195:Disease Models, Animal; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006041:Goats; D019736:Prostheses and Implants; D011859:Radiography; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes