Effects of cuminaldehyde on melanoma cells.
Cuminaldehyde (4-isopropylbenzaldehyde) suppressed melanin formation in cultured murine B16-F10 melanoma cells in a dose-dependent decrease up to 0.25 mm without affecting cell growth. Approximately 30% suppression in melanin production resulted when the cells were cultured with 0.25 mm of cuminaldehyde. This activity was not noticeable with cultured human A375 melanoma cells.
Nitoda
Teruhiko
T
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA. nitoda@cc.okayama-u.ac.jp
Fan
Maria D
MD
Kubo
Isao
I
D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000081007:Cymenes; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008543:Melanins / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism / Q000473:pathology; D051379:Mice; D015394:Molecular Structure
D001547:Benzaldehydes; D000081007:Cymenes; D008543:Melanins; C007165:cuminaldehyde