title: Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells.
abstract: Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis.
authors.affiliation: Department of Immunology, School of Medicine, Shandong University, Jinan 250012, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Cao
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liang
authors.forename: Yugang
authors.initials: Y
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Qu
authors.forename: Min
authors.initials: M
authors.lastname: Cui
authors.forename: Suxia
authors.initials: S
authors.lastname: Liu
authors.forename: Lifen
authors.initials: L
authors.lastname: Gao
authors.forename: Chunhong
authors.initials: C
authors.lastname: Ma
authors.forename: Lining
authors.initials: L
authors.lastname: Zhang
authors.forename: Lihui
authors.initials: L
authors.lastname: Han
authors.forename: Wensheng
authors.initials: W
authors.lastname: Sun
mesh_terms: D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000502:physiology; D023102:Anoikis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D019008:Drug Resistance, Neoplasm; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D014162:Transfection
chemical_list: C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins