title: Entecavir therapy induces de novo HIV reverse-transcriptase M184V mutation in an antiretroviral therapy-naive patient.
abstract: Recently, entecavir was introduced as a potent drug against hepatitis B virus infection. Initially, it was suggested not to have any effect on human immunodeficiency virus (HIV) infection. This guideline was revised in 2007 because of a report showing that the M184V mutation was selected in an hepatitis B virus and HIV-coinfected patient previously treated with lamivudine. Our investigation revealed findings similar to those preveiously reported but in an antiretroviral therapy-naive patient coinfected with HIV and hepatitis B virus. After 26 weeks of entecavir therapy, the M184V mutation dominated the plasma viral population. Thus, entecavir should only be used for coinfected patients who simultaneously receive suppressive therapy against HIV infection.
authors.affiliation: Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. mrj@sks.aaa.dk
authors.forename: Martin R
authors.initials: MR
authors.lastname: Jakobsen
authors.forename: Hanne
authors.initials: H
authors.lastname: Arildsen
authors.forename: Henrik B
authors.initials: HB
authors.lastname: Krarup
authors.forename: Martin
authors.initials: M
authors.lastname: Tolstrup
authors.forename: Lars
authors.initials: L
authors.lastname: Østergaard
authors.forename: Alex L
authors.initials: AL
authors.lastname: Laursen
mesh_terms: D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000187:drug effects*; D010802:Phylogeny; D054299:env Gene Products, Human Immunodeficiency Virus / Q000145:classification / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D054299:env Gene Products, Human Immunodeficiency Virus; C413685:entecavir; D006147:Guanine; D054303:HIV Reverse Transcriptase