title: Insulin signaling pathways and cardiac growth.
abstract: The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.
authors.affiliation: Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: DeBosch
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Muslin
mesh_terms: D000818:Animals; D006321:Heart / Q000254:growth & development*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism
chemical_list: D007328:Insulin; D013002:Somatomedins; D011972:Receptor, Insulin