Natural killer cell-directed therapies: moving from unexpected results to successful strategies.
Natural killer (NK) cells influence innate and adaptive immune host defenses. Existing data indicate that manipulating the balance between inhibitory and activating NK receptor signals, the sensitivity of target cells to NK cell-mediated apoptosis, and NK cell cross-talk with dendritic cells might hold therapeutic promise. Efforts to modulate NK cell trafficking into inflamed tissues and/or lymph nodes, and to counteract NK cell suppressors, might also prove fruitful in the clinic. However, deeper investigation into the benefits of combination therapy, greater understanding of the functional distinctions between NK cell subsets, and design of new tools to monitor NK cell activity are needed to strengthen our ability to harness the power of NK cells for therapeutic aims.
Terme
Magali
M
INSERM, U805, Institut Gustave Roussy, Institut Gustave Roussy, 39 Rue Camille Desmoulins, F-94805 Villejuif, Paris, France.
Ullrich
Evelyn
E
Delahaye
Nicolas F
NF
Chaput
Nathalie
N
Zitvogel
Laurence
L
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D009369:Neoplasms / Q000628:therapy*; D011971:Receptors, Immunologic / Q000276:immunology; D015398:Signal Transduction
D011971:Receptors, Immunologic