Novel fluorescent core-shell nanocontainers for cell membrane transport.
The synthesis and characterization of novel core-shell macromolecules consisting of a fluorescent perylene-3,4,9,10-tetracarboxdiimide chromophore in the center surrounded by a hydrophobic polyphenylene shell as a first and a flexible hydrophilic polymer shell as a second layer was presented. Following this strategy, several macromolecules bearing varying polymer chain lengths, different polymer shell densities, and increasing numbers of positive and negative charges were achieved. Because all of these macromolecules reveal a good water solubility, their ability to cross cellular membranes was investigated. In this way, a qualitative relationship between the molecular architecture of these macromolecules and the biological response was established.
Yin
Meizhen
M
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Kuhlmann
Christoph R W
CR
Sorokina
Ksenia
K
Li
Chen
C
Mihov
George
G
Pietrowski
Eweline
E
Koynov
Kaloian
K
Klapper
Markus
M
Luhmann
Heiko J
HJ
Müllen
Klaus
K
Weil
Tanja
T
D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004337:Drug Carriers / Q000493:pharmacokinetics*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics
D004337:Drug Carriers; D011108:Polymers; C041325:polyphenylene sulfide