title: [First acute rejection episode after renal transplantation: study of the histopathological characteristics according to the immunological risk].
abstract: Renal allograft biopsies (n=34) of two different populations of patients according to the immunological risk (high versus low-risk) have been compared retrospectively. The presence of polymorphonuclear leukocytes in peritubular capillaries was more frequent in the high-risk group. The C4d staining was positive in 10% of the low-risk patients and in 50% of the high-risk patients (P=0.03). There were more early graft loss, renal infarctions, interstitial hemorrhage, severe glomerulitis, neutrophilic glomerulitis and Banff III grade rejection in the positive C4d group. In conclusion, half of the immunized patients had a humoral rejection, patients with a C4d positive rejection had more early graft loss and more severe histological lesions.
authors.affiliation: Service de néphrologie, hôpital académique ULB-Erasme, 808, route de Lennik, 1070 Bruxelles, Belgique. lghisdal@yahoo.com <lghisdal@yahoo.com>
authors.forename: Lidia
authors.initials: L
authors.lastname: Ghisdal
authors.forename: Guy
authors.initials: G
authors.lastname: Touchard
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Goujon
authors.forename: David
authors.initials: D
authors.lastname: Buob
authors.forename: Dominique
authors.initials: D
authors.lastname: Durand
authors.forename: Georges
authors.initials: G
authors.lastname: Mourad
authors.forename: Philippe
authors.initials: P
authors.lastname: Lang
authors.forename: Michele
authors.initials: M
authors.lastname: Kessler
authors.forename: Renaud
authors.initials: R
authors.lastname: Snanoudj
authors.forename: François
authors.initials: F
authors.lastname: Berthoux
authors.forename: Pierre
authors.initials: P
authors.lastname: Merville
authors.forename: Nacéra
authors.initials: N
authors.lastname: Ouali
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Squifflet
authors.forename: François
authors.initials: F
authors.lastname: Bayle
authors.forename: Bruno
authors.initials: B
authors.lastname: Bourgeon
authors.forename: Gérard
authors.initials: G
authors.lastname: Rifle
authors.forename: Patrick
authors.initials: P
authors.lastname: Peeters
authors.forename: Michel
authors.initials: M
authors.lastname: Delahousse
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.forename: Bernard
authors.initials: B
authors.lastname: Bourbigot
authors.forename: Christian
authors.initials: C
authors.lastname: Noël
authors.forename: Daniel
authors.initials: D
authors.lastname: Abramowicz
mesh_terms: D000328:Adult; D001706:Biopsy; D015935:Complement C4b / Q000378:metabolism; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D015935:Complement C4b