miRiad roles for the miR-17-92 cluster in development and disease.
MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.
Mendell
Joshua T
JT
McKusick-Nathans Institute of Genetic Medicine, Departments of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jmendell@jhmi.edu
D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism*; D006321:Heart / Q000196:embryology; D006801:Humans; D007107:Immune System / Q000196:embryology; D008168:Lung / Q000196:embryology; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009857:Oncogenes; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*
C524941:MIRN17 microRNA, human; D035683:MicroRNAs; D012334:RNA, Neoplasm