title: [Effects of long term use of beclomethasone dipropionate nasal spray on bone density with perennial allergic rhinitis].
abstract: OBJECTIVE
  To study the effects of long term use of beclomethasone dipropionate (BDP) nasal spray on bone density with perennial allergic rhinitis (AR) in adults.
  
  
  METHODS
  A 5-year randomized study was conducted on the effects of BDP nasal spray on serum calcium, phosphorus, alkaline phosphatase, and bone density determined before and after the treatment in 36 adult patients with perennial AR. 20-45 years of age, were randomly divided into 3 groups. That is group A (nasal spray 1 - <3 year), group B (nasal spray BDP 3 - <5 year) and group C (nasal spray BDP > or =5 year). The data were analyzed by paired t test.
  
  
  RESULTS
  The perennial AR were followed up for more than > or =1 year, > or =3 year and > or =5 year to observe the influences of nasal spray BDP. There were no significant difference between the data examined before and after the treatment (P > 0.05). Bone development is not influenced by nasal spray BDP < or =400 microg/d within 5 years.
  
  
  CONCLUSIONS
  Long term use of BDP nasal spray in adult patients does not lead to osteoporosis if the lowest effective steroid dose is given.
authors.affiliation: Department of Otorhinolaryngology, the Central Hospital of Xiangfan City, Xiangfan, 441021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Luo
authors.forename: Qiyun
authors.initials: Q
authors.lastname: Tan
authors.forename: Guangmei
authors.initials: G
authors.lastname: Zhang
authors.forename: Shengwu
authors.initials: S
authors.lastname: Liu
authors.forename: Nengbing
authors.initials: N
authors.lastname: Yan
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Pingfan
authors.initials: P
authors.lastname: Zeng
authors.forename: Jinjun
authors.initials: J
authors.lastname: Liang
authors.forename: Pengju
authors.initials: P
authors.lastname: Wang
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult
chemical_list: D010758:Phosphorus; D000469:Alkaline Phosphatase; D001507:Beclomethasone; D002118:Calcium