title: Endothelial function in children with a history of premature prolonged rupture of membranes and bronchopulmonary dysplasia--a pilot study.
abstract: OBJECTIVE
  To investigate vascular function in children with a neonatal history of generalised inflammation indicated by premature prolonged rupture of membranes (PPROM) and bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  Children born at <or=30 weeks 1994-2000 were investigated at a present age of 6-12 years. Twenty-eight children participated and were divided into two groups with regard to BPD/no BPD (n=15/13) and PPROM/no PPROM (n=10/18). Vascular endothelial function was assessed by acetylcholine (ACh)-induced skin vasodilatation.
  
  
  RESULTS
  Maximum ACh-induced skin perfusion was statistically significantly lower in the PPROM group compared with the non-PPROM group (p=0.045) after adjustment for confounders. We found no association between BPD and maximum ACh-induced skin perfusion (p=0.404), after adjustment for confounders.
  
  
  CONCLUSIONS
  A neonatal history of prolonged premature rupture of membranes was associated with later impairment of vascular endothelial function in childhood. This association was not observed with BPD. Some forms of perinatal inflammation may be associated with later cardiovascular function.
authors.affiliation: Department of Paediatrics, Orebro University Hospital, Orebro, Sweden. magnus.liljedahl@orebroll.se
authors.forename: Magnus
authors.initials: M
authors.lastname: Liljedahl
authors.forename: Helena
authors.initials: H
authors.lastname: Martin
authors.forename: Anders
authors.initials: A
authors.lastname: Magnuson
authors.forename: Scott M
authors.initials: SM
authors.lastname: Montgomery
authors.forename: Jens
authors.initials: J
authors.lastname: Schollin
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D002648:Child; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011247:Pregnancy; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D000109:Acetylcholine