title: The increasing burden of alcoholic liver disease on United Kingdom critical care units: secondary analysis of a high quality clinical database.
abstract: OBJECTIVE
  To investigate the effect of increasing alcohol consumption on the number of admissions to adult, general critical/intensive care units (ICUs) in England and Wales with alcoholic liver disease, their case mix, mortality, and impact on critical care and hospital activity by extrapolating from admissions to ICUs over the last 10 years.
  
  
  METHODS
  Secondary analysis of a high quality clinical database from a national clinical audit using data from 385,429 admissions to174 ICUs in England and Wales between December 1995 and July 2005, of which 4219 (1.1%) had alcoholic liver disease. The extrapolated total number of admissions with alcoholic liver disease and total number of ICU bed-days occupied were calculated. Changes over time in the case mix (age, sex and APACHE II and ICNARC risk prediction models), mortality at ultimate discharge from acute hospital, and length of stay in ICU and in hospital were explored.
  
  
  RESULTS
  The percentage of ICU admissions with alcoholic liver disease increased from 0.65% in 1996 to 1.35% in 2005, but the case mix remained similar. Mortality decreased and length of stay increased over this period. The extrapolated total number of admissions to all 229 adult, general critical care units in England and Wales increased from 550 in 1996 to 1513 in 2005, and the extrapolated total number of bed-days occupied by these admissions increased from around 3100 to over 10,000.
  
  
  CONCLUSIONS
  Admissions to ICUs in England and Wales with alcoholic liver disease tripled over the 10-year period from 1996 to 2005. The continuing increase in alcohol consumption means that this trend is likely to continue.
authors.affiliation: Intensive Care National Audit & Research Centre, London, UK. cathy.welch@icnarc.org
authors.forename: Catherine
authors.initials: C
authors.lastname: Welch
authors.forename: David
authors.initials: D
authors.lastname: Harrison
authors.forename: Alasdair
authors.initials: A
authors.lastname: Short
authors.forename: Kathryn
authors.initials: K
authors.lastname: Rowan
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D017281:Cost of Illness; D019992:Databases as Topic; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008103:Liver Cirrhosis / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D014852:Wales / Q000453:epidemiology