title: Recognition memory and prefrontal cortex: dissociating recollection and familiarity processes using rTMS.
abstract: Recognition memory can be supported by both the assessment of the familiarity of an item and by the recollection of the context in which an item was encountered. The neural substrates of these memory processes are controversial. To address these issues we applied repetitive transcranial magnetic stimulation (rTMS) over the right and left dorsolateral prefrontal cortex (DLPFC) of healthy subjects performing a remember/know task. rTMS disrupted familiarity judgments when applied before encoding of stimuli over both right and left DLPFC. rTMS disrupted recollection when applied before encoding of stimuli over the right DLPFC. These findings suggest that the DLPFC plays a critical role in recognition memory based on familiarity as well as recollection.
authors.affiliation: Dipartimento di Psicologia, Università di Palermo, Palermo, Italy. p.turriziani@hsantalucia.it
authors.forename: Patrizia
authors.initials: P
authors.lastname: Turriziani
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Oliveri
authors.forename: Silvia
authors.initials: S
authors.lastname: Salerno
authors.forename: Floriana
authors.initials: F
authors.lastname: Costanzo
authors.forename: Giacomo
authors.initials: G
authors.lastname: Koch
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
authors.forename: Giovanni Augusto
authors.initials: GA
authors.lastname: Carlesimo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007600:Judgment; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall; D017397:Prefrontal Cortex / Q000502:physiology*; D021641:Recognition, Psychology; D050781:Transcranial Magnetic Stimulation