The use of proton NMR as an alternative for the amino acid analysis as identity test for peptides.
Proton NMR was evaluated as an alternative to amino acid analysis as an identity test for peptides. Proton NMR can readily distinguish and identify all peptides currently described in the European Pharmacopoeia (Ph. Eur.). A comparison with amino acid analysis as an identity test is presented.
Kellenbach
E
E
NV Organon, Quality & Regulatory Unit, The Netherlands.
Sanders
K
K
Zomer
G
G
Overbeeke
P L A
PL
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008969:Molecular Sequence Data; D010455:Peptides / Q000032:analysis*
D000596:Amino Acids; D010455:Peptides