title: Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.
abstract: The synergy of the activities between chloroquine and various human immunodeficiency virus protease inhibitors was investigated in chloroquine-resistant and -sensitive malaria parasites. In both in vitro and in vivo assay systems, ritonavir was found to be the most potent in potentiating the antimalarial action of chloroquine.
authors.affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510663, China.
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.forename: Nanzheng
authors.initials: N
authors.lastname: Peng
authors.forename: Jianlan
authors.initials: J
authors.lastname: You
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage*; D000069446:Atazanavir Sulfate; D002738:Chloroquine / Q000008:administration & dosage*; D004351:Drug Resistance; D004357:Drug Synergism; D005260:Female; D017320:HIV Protease Inhibitors / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D061466:Lopinavir; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D019888:Nelfinavir / Q000008:administration & dosage; D009842:Oligopeptides / Q000008:administration & dosage; D016788:Plasmodium chabaudi / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011725:Pyridines / Q000008:administration & dosage; D011744:Pyrimidinones / Q000008:administration & dosage; D019438:Ritonavir / Q000008:administration & dosage; D019258:Saquinavir / Q000008:administration & dosage
chemical_list: D000962:Antimalarials; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011725:Pyridines; D011744:Pyrimidinones; D061466:Lopinavir; D000069446:Atazanavir Sulfate; D002738:Chloroquine; D019888:Nelfinavir; D019258:Saquinavir; D019438:Ritonavir