[Accelerated postoperative chemoradiotherapy for malignant cerebral glioma].
Procedure of accelerated immunotherapy for cerebral glioma is presented. Large fractions of radiation ranged from 3 Gy, 5 times a week, to a total focal dose of 51 Gy. After accumulation of total doses of 18, 33 and 48 Gy, vincristine was injected intravenously. Urea derivatives were given on reaching 21, 36 and 51 Gy. Treatment with the immunomodulator roncoleukine was carried out on completion of radiotherapy. An evaluation of the immediate end results of accelerated immunotherapy showed improved survival as compared with standard treatment.
Kartashev
A V
AV
Vinogradov
V M
VM
Oliushin
V E
VE
Gerasimov
S V
SV
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000628:therapy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D016371:Cranial Irradiation; D019583:Dose Fractionation, Radiation; D005260:Female; D005909:Glioblastoma / Q000628:therapy; D005910:Glioma / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D011184:Postoperative Period; D018714:Radiotherapy, Adjuvant; D011994:Recombinant Proteins; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
D007155:Immunologic Factors; D009607:Nitrosourea Compounds; D011994:Recombinant Proteins; D014750:Vincristine; C081222:sargramostim; D016178:Granulocyte-Macrophage Colony-Stimulating Factor