title: Prevalence and significance of psammoma bodies in cervicovaginal smears in a cervical cancer screening program with emphasis on a case of primary bilateral ovarian psammocarcinoma.
abstract: BACKGROUND
  The purpose of our study was to determine the prevalence and significance of psammoma bodies (PBs) in the cervicovaginal smears of the screening population of Trento district (Italy), with the description of the cytological presentation of an asymptomatic bilateral ovarian psammocarcinoma.
  
  
  METHODS
  From 1993 to 2006, women with PBs detected on consecutively screened cervical smears were identified from the computerized pathology database of Rovereto Hospital. The follow-up period was set from the time of cytological diagnosis to May 31st, 2007. Clinical information was obtained from retrospective review of women's medical records. The source of PBs was identified with adequate diagnostic procedures.
  
  
  RESULTS
  PBs were found in six of the 201,231 Papanicolaou screening smears (0.0029%). Benign conditions (intrauterine device, inclusion ovarian cysts and ovarian cystoadenofibroma with PBs) were found in four patients. In two cases, PBs were associated with malignant cells; a bilateral ovarian malignancy was diagnosed in both cases, a serous adenocarcinoma and a psammocarcinoma.
  
  
  CONCLUSIONS
  PBs in the cervicovaginal smears are a rare finding, associated more often with benign conditions than with malignancies. Moreover, to our knowledge, our case of primary ovarian psammocarcinoma is the first report in which the presence of malignant cells and PBs in the cervicovaginal and endometrial smears represents the first manifestation of disease.
authors.affiliation: Department of Pathology, National Institute for Infectious Diseases - L, Spallanzani IRCCS, Rome, Italy. teresa.pusiol@apss.tn.it
authors.forename: Teresa
authors.initials: T
authors.lastname: Pusiol
authors.forename: Anna M
authors.initials: AM
authors.lastname: Parolari
authors.forename: Irene
authors.initials: I
authors.lastname: Piscioli
authors.forename: Luca
authors.initials: L
authors.lastname: Morelli
authors.forename: Franca
authors.initials: F
authors.lastname: Del Nonno
authors.forename: Stefano
authors.initials: S
authors.lastname: Licci