Dendrimerized cellulose as a scaffold for artificial antigens with applications in drug allergy diagnosis.
Cellulose-based dendrimerized material was prepared and its quality was assessed by determining the number of amine functional groups incorporated. Based on the results for a series of preparations, the material was obtained in a highly reproducible manner thanks to the particular chemical construction method used. The number of amine groups incorporated and the amount of dendrimer attached are directly related to the dendrimer generation. The combination of the properties of the cellulose polymer and those of the dendrimeric state provides biocompatible materials amenable to easy chemical characterization. The proposed method provides an effective tool for developing clinically testable materials with a view to studying adverse immunological responses to drugs in humans.
Montañez
Maria I
MI
Department of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Malaga, Spain.
Perez-Inestrosa
Ezequiel
E
Suau
Rafael
R
Mayorga
Cristobalina
C
Torres
Maria J
MJ
Blanca
Miguel
M
D000588:Amines / Q000032:analysis; D000941:Antigens; D001672:Biocompatible Materials / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D050091:Dendrimers; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans
D000588:Amines; D000941:Antigens; D001672:Biocompatible Materials; D050091:Dendrimers; D002482:Cellulose