title: Epigenetics, brain evolution and behaviour.
abstract: Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced according to parent-of-origin. This form of gene regulation is primarily under matrilineal control and has evolved partly to co-ordinate in-utero development with maternal resource availability. Changes to epigenetic mechanisms in post-mitotic neurons may also be activated during development in response to environmental stimuli such as maternal care and social interactions. This results in long-lasting stable, or short-term dynamic, changes to the neuronal phenotype producing long-term behavioural consequences. Use of evolutionary conserved mechanisms have thus been adapted to modify the control of gene expression and embryonic growth of the brain as well as allowing for plastic changes in the post-natal brain in response to external environmental and social cues.
authors.affiliation: Sub-Department of Animal Behaviour, University of Cambridge, Madingley, Cambridge, CB23 8AA, UK. ebk10@cam.ac.uk
authors.forename: Eric B
authors.initials: EB
authors.lastname: Keverne
authors.forename: James P
authors.initials: JP
authors.lastname: Curley
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005075:Biological Evolution; D001921:Brain / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000378:metabolism; D006801:Humans; D008297:Male; D010375:Pedigree; D010920:Placenta / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones