Comparison of 18F-FDG PET and MRI in assessment of uterine smooth muscle tumors.
The purpose of this study was to prospectively determine whether combined MRI and (18)F-FDG PET is more accurate than MRI in assessing nonbenign uterine smooth muscle tumors (USMTs).


METHODS
Seventy patients (mean age, 49+/-10 y; range, 28-77 y) suspected of having nonbenign USMTs underwent both MRI and (18)F-FDG PET before surgery. Results were evaluated using receiver-operating-characteristic (ROC) analyses and the Cochran Q test.


RESULTS
The area under the ROC curve for MRI with (18)F-FDG PET was significantly higher than that for MRI (0.97 vs. 0.89, P<0.05). Although multiple comparisons using the Cochran Q test were not significant, the sensitivity, specificity, and accuracy for MRI with (18)F-FDG PET with probable nonbenign USMT cases considered to be positive were higher than those for MRI (93.3% vs. 73.3%; 92.7% vs. 85.5%; and 92.9% vs. 82.9%, respectively).


CONCLUSIONS
MRI with (18)F-FDG PET is useful in assessing nonbenign USMTs, as compared with MRI.
Yoshida
Yoshio
Y
Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Eihaiji-cho, Yoshida-gun, Fukui Prefecture, Japan. yyoshida@u-fukui.ac.jp
Kurokawa
Tetsuji
T
Sawamura
Yoko
Y
Shinagawa
Akiko
A
Tsujikawa
Tetsuya
T
Okazawa
Hidehiko
H
Tsuchida
Tatsuro
T
Imamura
Yoshiaki
Y
Suganuma
Narufumi
N
Kotsuji
Fumikazu
F
D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009215:Myometrium / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods*; D012680:Sensitivity and Specificity; D018235:Smooth Muscle Tumor / Q000000981:diagnostic imaging*
D019788:Fluorodeoxyglucose F18