title: Outbreak of OXY-2-Producing Klebsiella oxytoca in a renal transplant unit.
abstract: We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal beta-lactamase hyperproduction was caused by a point mutation in the bla(OXY-2) gene promoter region.
authors.affiliation: Laboratorio de Bacteriología, Micología y Parasitología, Sección de Nefrología, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno CEMIC, Ciudad Autónoma de Buenos Aires, Argentina. sole_z@hotmail.com
authors.forename: Mariela Soledad
authors.initials: MS
authors.lastname: Zárate
authors.forename: Ana C
authors.initials: AC
authors.lastname: Gales
authors.forename: Renata C
authors.initials: RC
authors.lastname: Picão
authors.forename: Gervasio Soler
authors.initials: GS
authors.lastname: Pujol
authors.forename: Alejandra
authors.initials: A
authors.lastname: Lanza
authors.forename: Jorgelina
authors.initials: J
authors.lastname: Smayevsky
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D006757:Hospital Units; D006801:Humans; D016030:Kidney Transplantation; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D041121:Klebsiella oxytoca / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D017354:Point Mutation; D011401:Promoter Regions, Genetic; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases