title: In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A.
abstract: We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was comparable to that of linezolid.
authors.affiliation: Pfizer Global Research & Development, Groton/New London Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA. gregory.stone@astrazeneca.com
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Stone
authors.forename: Dennis
authors.initials: D
authors.lastname: Girard
authors.forename: Steve
authors.initials: S
authors.lastname: Finegan
authors.forename: Joan
authors.initials: J
authors.lastname: Duignan
authors.forename: John
authors.initials: J
authors.lastname: Schafer
authors.forename: Meghan
authors.initials: M
authors.lastname: Maloney
authors.forename: Richard P
authors.initials: RP
authors.lastname: Zaniewski
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Brickner
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Wade
authors.forename: Phuong T
authors.initials: PT
authors.lastname: Le
authors.forename: Michael D
authors.initials: MD
authors.lastname: Huband
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D004149:Dioxoles / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D006921:Hygromycin B / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; C531326:CE 156811; D002934:Cinnamates; D004149:Dioxoles; D023303:Oxazolidinones; D006921:Hygromycin B; C026273:hygromycin A; D000069349:Linezolid