Effects of bacterial lipopolysaccharide on the pharmacokinetics of DA-8159, a new erectogenic, in rats.
Pharmacokinetic parameters of DA-8159 and one of its metabolites, DA-8164, were compared after intravenous and oral administration of DA-8159 at a dose of 30 mg/kg to control rats and rats pretreated with Klebsiella pneumoniae lipopolysaccharide (KPLPS). After intravenous and oral administration of DA-8159, most of the pharmacokinetic parameters of DA-8159 and DA-8164 were not significantly different between two groups of rats. This suggested that the pharmacokinetic parameters of DA-8159 and DA-8164 were not affected considerably by KPLPS.
Lee
Joo H
JH
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea.
Kim
Yu C
YC
Kwon
Jong W
JW
Kim
Won B
WB
Lee
Myung G
MG
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D007172:Erectile Dysfunction / Q000188:drug therapy; D006207:Half-Life; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007711:Klebsiella pneumoniae / Q000737:chemistry; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000493:pharmacokinetics* / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011687:Purines / Q000494:pharmacology; D011743:Pyrimidines / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D000068677:Sildenafil Citrate; D013449:Sulfonamides; D013450:Sulfones / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D000096926:Benzenesulfonamides
D008070:Lipopolysaccharides; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D000068677:Sildenafil Citrate; D013449:Sulfonamides; D013450:Sulfones; D014665:Vasodilator Agents; C502127:DA-8164; C419664:udenafil; D000096926:Benzenesulfonamides