Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues.
OBJECTIVE
The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues.


METHODS
Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time.


RESULTS
In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days.


CONCLUSIONS
Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.
de Campos-Pinto
Mônica Maria Denadae
MM
School of Dentistry, University of Ribeirao Preto, Ribeirao Preto, Brazil.
de Oliveira
Danilo Alessandro
DA
Versiani
Marco Aurélio
MA
Silva-Sousa
Yara Teresinha Correa
YT
de Sousa-Neto
Manoel Damião
MD
da Cruz Perez
Danyel Elias
DE
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D018836:Inflammation Mediators; D008027:Light; D008297:Male; D008422:Materials Testing; D009336:Necrosis; D051381:Rats; D012387:Root Canal Filling Materials / Q000633:toxicity*; D040521:Subcutaneous Tissue / Q000187:drug effects*; D013997:Time Factors
D001672:Biocompatible Materials; D018836:Inflammation Mediators; D012387:Root Canal Filling Materials; C486893:epiphany sealer