title: The influence of drug use on fall incidents among nursing home residents: a systematic review.
abstract: BACKGROUND
  Falls are a major health problem among the elderly, particularly in nursing homes. Abnormalities of balance and gait, psychoactive drug use, and dementia have been shown to contribute to fall risk.
  
  
  METHODS
  We conducted a systematic review of the literature to investigate which psychoactive drugs increase fall risk and what is known about the influence of these drugs on gait in nursing home residents with dementia. We included studies with a prospective cohort design on psychoactive drug use in nursing homes with dementia residents and with falls as an outcome measure.
  
  
  RESULTS
  Seventeen studies were included in the review. Pooled risk estimates were not calculated because there was no homogeneity across studies. We assessed the strength of evidence for psychoactive drugs as a prognostic factor for falls by defining four levels of evidence: strong, moderate, limited or inconclusive. Strong evidence was defined as consistent findings (> or =80%) in at least two high quality cohorts. We found strong evidence that the use of multiple drugs (3/3 cohorts, effect sizes 1.30-1 xs 0.30), antidepressants (10/12 cohorts, effect sizes 1.10-7.60), and anti-anxiety drugs (2/2 cohorts, effect sizes 1.22-1.32) is associated with increased fall risk. The evidence for the association of other psychoactive drug classes with fall risk was limited or inconclusive.
  
  
  CONCLUSIONS
  Research on the contribution of psychoactive drugs to fall risk in nursing home residents with dementia is limited. The scarce evidence shows, however, that multiple drugs, antidepressants and anti-anxiety drugs increase fall risk in nursing home populations with residents with dementia.
authors.affiliation: De StromenOpmaatGroep, Nursing Home Smeetsland, Rotterdam, the Netherlands.
authors.forename: Carolyn S
authors.initials: CS
authors.lastname: Sterke
authors.forename: Arianne P
authors.initials: AP
authors.lastname: Verhagen
authors.forename: Ed F
authors.initials: EF
authors.lastname: van Beeck
authors.forename: Tischa J M
authors.initials: TJ
authors.lastname: van der Cammen
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data*; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D015331:Cohort Studies; D003704:Dementia / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009735:Nursing Homes / Q000706:statistics & numerical data*; D011379:Prognosis; D011619:Psychotropic Drugs / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012307:Risk Factors
chemical_list: D011619:Psychotropic Drugs