title: Development of carcinoid tumors of the glandular stomach and effects of eradication in Helicobacter pylori-infected Mongolian gerbils.
abstract: The relation between Helicobacter pylori (Hp) eradication and prevention of stomach carcinoid development has hitherto remained unclear. We therefore examined this problem using an Hp-infected and Hp-eradicated Mongolian gerbil (MG) model. Enterochromaffin-like (ECL) lesions (hyperplasia/dysplasia and carcinoid) were histopathologically evaluated in the glandular stomachs of Hp-infected and Hp-eradicated MGs. In addition, serum gastrin levels were analyzed. Hp infection induced significant increase in the development of ECL lesions in the glandular stomach, as well as serum gastrin levels as compared with non-infected MGs, while Hp eradication was associated with significant alleviation. The development of ECL lesions in the glandular stomach strongly correlated with titers of anti-Hp antibodies and serum gastrin levels in MGs. In conclusion, Hp infection induces carcinoid development, and Hp eradication prevents its occurrence in the glandular MG stomach, this being strongly linked with reduction in serum gastrin levels.
authors.affiliation: Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa, Nagoya, Japan.
authors.forename: Liyu
authors.initials: L
authors.lastname: Cao
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Toyoda
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Cao
authors.forename: Hisayo
authors.initials: H
authors.lastname: Ban
authors.forename: Koji
authors.initials: K
authors.lastname: Nozaki
authors.forename: Masae
authors.initials: M
authors.lastname: Tatematsu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002276:Carcinoid Tumor / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D019861:Enterochromaffin-like Cells / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects / Q000472:pathogenicity*; D006965:Hyperplasia; D008297:Male; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D005755:Gastrins