[Epstein-Barr virus-associated large B-cell lymphoma in a patient with colitis ulcerosa treated with azathioprine].
A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV-associated large B-cell lymphoma was confirmed, he died from multiple organ failure. AZA and 6-mercaptopurine are associated with the development of EBV-positive lymphomas in organ-transplanted patients. This type of lymphoma is a rare complication in inflammatory bowel disease.
Kofoed
Kristian
K
Hvidovre Hospital, Klinisk Forskningsenhed 136, Infektionsmedicinsk Afdeling, Hvidovre. kristian.kofoed@hvh.regionh.dk
Kiszka-Kanowitz
Marianne
M
Albrectsen
Jens Mørch
JM
Andersen
Ove
O
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016393:Lymphoma, B-Cell / Q000821:virology*; D008297:Male; D009102:Multiple Organ Failure / Q000821:virology
D007166:Immunosuppressive Agents; D001379:Azathioprine