title: Peer environment mediates parental history and individual risk in the etiology of cannabis use disorder in boys: a 10-year prospective study.
abstract: Previous research has shown that a trait termed neurobehavior disinhibition (ND) measured in childhood predicts substance use disorder by young adulthood. The present investigation extends these findings by determining the degree to which peer environment mediates the association between ND and development of cannabis use disorder (CUD). ND was measured in a sample of 216 boys 10-12 years of age. The peer environment was assessed at age 16. Current CUD was determined at age 22. Paternal and maternal SUD predicted son's ND which, in turn, predicted son's peer environment and, subsequently, son's cannabis use frequency and CUD. Peer environment mediated the association between ND and cannabis use and ND and CUD. Maternal and paternal SUD predicted the peer environment. Parental SUD, son's ND, and son's peer environment predicted CUD at age 22 with 84% accuracy.
authors.affiliation: Center for Education and Drug Abuse Research (CEDAR), School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. ulf1@pitt.edu
authors.forename: Ulrike
authors.initials: U
authors.lastname: Feske
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Tarter
authors.forename: Levent
authors.initials: L
authors.lastname: Kirisci
authors.forename: Zhongcui
authors.initials: Z
authors.lastname: Gao
authors.forename: Maureen
authors.initials: M
authors.lastname: Reynolds
authors.forename: Michael
authors.initials: M
authors.lastname: Vanyukov
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D016241:Child of Impaired Parents / Q000523:psychology*; D005220:Fathers / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D002189:Marijuana Abuse / Q000453:epidemiology / Q000523:psychology*; D009035:Mothers / Q000523:psychology; D016487:Parenting / Q000523:psychology; D010379:Peer Group; D011446:Prospective Studies; D012306:Risk; D019966:Substance-Related Disorders / Q000150:complications / Q000453:epidemiology; D011795:Surveys and Questionnaires