A murine model of retroviral encephalopathy.
This unit delineates the steps for production of a murine model of retroviral encephalopathy. The LP-BM5 infected mouse develops a chronic inflammation of the brain secondary to profound immune deficiency. The model is robust, develops rapidly and does not require the use of human pathogens. In addition, the behavioral and neurochemical characteristics of this model is reviewed.
Sei
Yoshitatsu
Y
Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Basile
Anthony S
AS
D000818:Animals; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000276:immunology / Q000473:pathology / Q000821:virology*; D009052:Leukemia Virus, Murine / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D007942:Leukemia, Experimental / Q000276:immunology / Q000473:pathology / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D014412:Tumor Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology