title: Unequal tissue expression of proteins from the PA/PAI system, myoma necrosis, and uterus survival after uterine artery occlusion.
abstract: OBJECTIVE
  To further the understanding of the mechanism behind myoma necrosis and uterus survival after uterine artery occlusion.
  
  
  METHODS
  Myomal and myometrial gene transcription and protein expression of tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor type 1 (PAI-1) were investigated in 30 uteri.
  
  
  RESULTS
  Compared with myometrial expression, myomal expression was less for uPA mRNA (1.34%+/-2.18% vs 2.84%+/-2.97%; P<0.05) and greater for PAI-1 mRNA (2.67%+/-1.82% vs 1.27%+/-1.99%; P<0.05), but the difference in tPA mRNA expression was not significant. Accordingly, compared with myometrial expression, myomal expression was less for the uPA protein (P<0.05) and greater for the PAI-1 protein (P<0.05), but the difference in tPA protein was not significant.
  
  
  CONCLUSIONS
  The PA/PAI system was found to be expressed differently in myomas and the myometrium, which may play a role in uterus survival and myoma necrosis after uterine artery occlusion.
authors.affiliation: Department of Obstetrics and Gynecology, Yangpu District Central Hospital, Shanghai, China. mdcheng18@263.net
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Cheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Xie
authors.forename: Hong
authors.initials: H
authors.lastname: Dai
authors.forename: Liping
authors.initials: L
authors.lastname: Hu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000628:therapy*; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000628:therapy*; D014599:Uterus / Q000098:blood supply
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator