title: Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.
abstract: Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.
authors.affiliation: Anadys Pharmaceuticals, Inc., San Diego, USA.
authors.forename: Yuefen
authors.initials: Y
authors.lastname: Zhou
authors.forename: Chun
authors.initials: C
authors.lastname: Chow
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Murphy
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Sun
authors.forename: Thomas
authors.initials: T
authors.lastname: Bertolini
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Froelich
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Webber
authors.forename: Thomas
authors.initials: T
authors.lastname: Hermann
authors.forename: Daniel
authors.initials: D
authors.lastname: Wall
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D003959:Diamines / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003959:Diamines; D010880:Piperidines