The role of cerebellar genes in pathology of autism and schizophrenia.
Schizophrenia and autism are neurodevelopmental diseases that have genetic as well as environmental etiologies. Both disorders have been associated with prenatal viral infection. Brain imaging and postmortem studies have found alterations in the structure of the cerebellum as well as changes in gene expression. Our laboratory has developed an animal model using prenatal infection of mice with human influenza virus that has demonstrated changes in behavior, pharmacology, structure, and gene expression in the brains of exposed offspring. In the current communication we describe altered expression of cerebellar genes associated with development of brain disorder in a mouse model for schizophrenia and autism and correlate these changes with those involved in the pathology of these two disorders.
Fatemi
S Hossein
SH
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, MMC 392, 420 Delaware Street S.E., Minneapolis, MN 55455, USA. fatem002@umn.edu
Reutiman
Teri J
TJ
Folsom
Timothy D
TD
Sidwell
Robert W
RW
D000818:Animals; D001321:Autistic Disorder / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics; D002531:Cerebellum / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D009980:Influenza A virus / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D012559:Schizophrenia / Q000235:genetics*; D013047:Specific Pathogen-Free Organisms
D018797:Cell Cycle Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D019204:GTP-Binding Proteins