[Evaluation of the event-related potential (ERP-P300) in patients with hepatic cirrhosis without encephalopathy].
In hepatic cirrhosis structural liver alterations occur leading to the loss of the organ functions with neuro-psychiatric consequence, as cognitive dysfunctions. One of the most effective ways of objectively evaluating cognition is to measure electrophysiological activity in the central nervous system trough event-related potentials (ERP-P300).



To assess the value of the event-related potential (ERP) in order to determine cognitive disturbances in patients with liver cirrhosis and to assist in the diagnosis of minimal hepatic encephalopathy.



Fifty patients with liver cirrhosis were selected, without clinical symptoms of hepatic encephalopathy and 35 healthy volunteers, matched by sex and age. The patients were submitted to clinical-neurological and laboratorial examination. The ERP-P300 was performed by the two groups to determine cognitive disturbances.



The study showed significant differences between the ERP-P300 latency averages of the two groups.



The ERP-P300 is simple to use and depends on controllable variables. It is also easy to reproduce and, when properly used, can be useful both to determine cognitive disturbances in patients with hepatic cirrhosis and to assist in minimal hepatic encephalopathy diagnosis.
Teodoro
Vinicius
V
Departamento de Gastroenterologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP. viniteodoro@uol.com.br
Bragagnolo
Maurício
M
Lucchesi
Lígia
L
Kondo
Mário
M
Tufik
Sérgio
S
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006501:Hepatic Encephalopathy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D015203:Reproducibility of Results