title: Orbital tumour as initial manifestation of acute myeloid leukemia: granulocytic sarcoma: case report.
abstract: We report orbital involvement as an initial manifestation of acute myeloid leukemia in a 57-year-old woman. The patient presented with painful proptosis and limited ocular motility. Orbital computed tomography revealed bilateral homogeneous masses. Orbital biopsy was performed on the right side; and histopathology disclosed a myelocytic tumour. Despite treatment using irradiation and chemotherapy, the patient died eleven months after presentation. There appear to be only a few previous reports of acute myeloid leukemia cases presenting with orbital involvement, and most cases occurred in children. This very rare condition has a poor survival prognosis, even with radiation treatment and chemotherapy.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Tömo utca 25-29, 1083, Budapest, Hungary. maker@szem1.sote.hu
authors.forename: Erika
authors.initials: E
authors.lastname: Maka
authors.forename: Olga
authors.initials: O
authors.lastname: Lukáts
authors.forename: Jeannette
authors.initials: J
authors.lastname: Tóth
authors.forename: Sándor
authors.initials: S
authors.lastname: Fekete
mesh_terms: D000208:Acute Disease; D003937:Diagnosis, Differential; D005094:Exophthalmos / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed