title: Microbial transformation of the diterpene mulin-11,13-dien-20-oic acid by Mucor plumbeus.
abstract: Two new mulinane-type derivatives: 16-hydroxy mulin-11,13-dien-20-oic (2) acid and 7alpha,16-dihydroxy mulin-11,13-dien-20-oic (3) acid were obtained by microbial transformation of mulin-11,13-dien-20-oic acid (1), along with tyrosol (4) using liquid cultures of Mucor plumbeus. The latter compound has not been previously identified in the genus Mucor. Structural elucidation of these metabolites was achieved using 1D- and 2D-NMR spectroscopy.
authors.affiliation: Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Areche
authors.forename: Luis A
authors.initials: LA
authors.lastname: Loyola
authors.forename: Jorge
authors.initials: J
authors.lastname: Borquez
authors.forename: Juana
authors.initials: J
authors.lastname: Rovirosa
authors.forename: Aurelio
authors.initials: A
authors.lastname: San-Martin
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000254:growth & development / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C530407:16-hydroxymulin-11,13-dien-20-oic acid; C530408:7alpha,16-dihydroxymulin-11,13-dien-20-oic acid; D004224:Diterpenes; C530406:mulin-11,13-dien-20-oic acid