Reduced expression of glyoxalase-1 mRNA in mood disorder patients.
Glyoxalase-1 (Glo1) is an antioxidant enzyme which detoxifies alpha-ketoaldehydes to prevent the accumulation of pro-oxidant compounds, such as methylglyoxal, in all cell types. Glo1 has been suggested to be involved in anxiety disorders, autism, and Alzheimer's disease. Mood disorders have a high rate of comorbidity with anxiety disorders although, to date, little is known of the involvement of Glo1 in the pathophysiology of these conditions. In the present study, we examined the expression levels of Glo1 mRNA in peripheral white blood cells of mood disorder patients to understand the role of Glo1 in mood disorders. Quantitative real-time polymerase chain reaction experiments revealed that reduced expression of Glo1 mRNA was observed in major depressive and bipolar disorder patients in a current depressive state, as compared with healthy control subjects. In contrast, the expression of Glo1 mRNA in major depressive and bipolar patients, in a remissive state, showed no significant alteration when compared with healthy control subjects. These results suggest that the aberrant expression of Glo1 might be involved in the pathophysiology of mood disorders.
Fujimoto
Michiko
M
Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
Uchida
Shusaku
S
Watanuki
Toshio
T
Wakabayashi
Yusuke
Y
Otsuki
Koji
K
Matsubara
Toshio
T
Suetsugi
Masatomo
M
Funato
Hiromasa
H
Watanabe
Yoshifumi
Y
D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D001921:Brain / Q000201:enzymology* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D003865:Major Depressive Disorder / Q000097:blood / Q000201:enzymology / Q000235:genetics; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015415:Biomarkers; D012333:RNA, Messenger; D007791:Lactoylglutathione Lyase