title: Short-term hyperglycemic dysregulation in patients with type 1 diabetes does not change myocardial triglyceride content or myocardial function.
abstract: OBJECTIVE
  To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes.
  
  
  METHODS
  Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10).
  
  
  RESULTS
  Mean insulin infusion rate was 45 +/- 5 units at baseline, whereas it was 27 +/- 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 +/- 0.6 to 15.9 +/- 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 +/- 0.05 to 0.46 +/- 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function.
  
  
  CONCLUSIONS
  Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.
authors.affiliation: Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands. s.hammer@lumc.nl
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Hammer
authors.forename: Jacqueline T
authors.initials: JT
authors.lastname: Jonker
authors.forename: Hildo J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: Rutger W
authors.initials: RW
authors.lastname: van der Meer
authors.forename: Wendy
authors.initials: W
authors.lastname: Zondag
authors.forename: Jan M
authors.initials: JM
authors.lastname: Sepers
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
authors.forename: Johannes W A
authors.initials: JW
authors.lastname: Smit
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Romijn
mesh_terms: D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006334:Heart Function Tests; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides