[Value of analysis of bilirubin in bile in predicting liver function in early stage after liver transplantation].
OBJECTIVE
To analyse the prognostic value of analysis of bilirubin in bile for early liver function after liver transplantation.


METHODS
The bile was filtered through 0.2 mum pall filter and was diluted 30 times with deionized water to reach the reaction linear range. Fifty-one cases of liver transplantation patients were investigated. Total bilirubin (TBil)-sulfonic crystal racemic mixture (SCR) method was used. Totally 510 bile samples for a duration of 1-10 post operation days (POD) were collected and tested. Bile total bilirubin (B-TBil), the quantity of biliary bilirubin secretion (Q-BTBil) and biliary direct bilirubin (DBil)/TBil rate of groups of better liver function (group A, n=30), less favorable function (group B, n=10), and poor liver function (group C, n=11) were analyzed. Trends of above three indexes in the 3 group were compared during 1-10 POD. Indexes were compared between 3 groups on POD 5. Correlation of B-TBil and bile total bile acid (B-TBA) was analyzed during 1-10 POD.


RESULTS
B-TBil, Q-BTBil and bile DBil/TBil could reflected the recovery of early liver function by clinical observation on 3 groups. The changes of every index was positive correlated within 1-10 POD between groups(P<0.05 or P<0.01). On POD 5, B-TBil and Q-BTBil in group C were lower than those of in group A and B statistical significantly, biliary DBil/TBil in group C was lower than that of in group A significantly (all P<0.05). B-TBil and B-TBA had positive correlations (P<0.05 or P<0.01) within POD 10 except POD 1 and POD 6.


CONCLUSIONS
B-TBil, Q-BTBil and biliary DBil/TBil rate had some prognostic value on early liver function after liver transplantation.
Chen
Li
L
The First Central Hospital of Tianjin, Tianjin 300192, China.
Peng
Lin
L
Zheng
Hong
H
Wang
Jian
J
Gao
Qiang
Q
Shen
Zhong-Yang
ZY
D000328:Adult; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests
D001663:Bilirubin