Polymeric nanoparticles for hemoglobin-based oxygen carriers.
This article reports on the current status of the research on blood substitutes with particular attention on hemoglobin-based oxygen carriers (HBOCs). Insights on the physiological role of hemoglobin are reported in the view of the development of both acellular and cellular hemoglobin-based oxygen carriers. Attention is then focused on biocompatible polymeric materials that find application as matrices for cellular based HBOCs and on the strategies employed to avoid methemoglobin formation. Results are reported regarding the use of bioerodible polymeric matrices based on hemiesters of alternating copolymer (maleic anhydride-co-butyl vinyl ether) for the preparation of hemoglobin loaded nanoparticles.
Piras
Anna Maria
AM
Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Application UdR-INSTM Consortium Reference Center, University of Pisa, Pisa, Italy.
Dessy
Alberto
A
Chiellini
Federica
F
Chiellini
Emo
E
Farina
Claudio
C
Ramelli
Massimiliano
M
Della Valle
Elena
E
D000328:Adult; D000375:Aging / Q000502:physiology; D000818:Animals; D001704:Biopolymers / Q000627:therapeutic use*; D001802:Blood Substitutes / Q000627:therapeutic use*; D004337:Drug Carriers / Q000378:metabolism / Q000627:therapeutic use; D004912:Erythrocytes / Q000378:metabolism; D005312:Fetal Blood / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008706:Methemoglobin / Q000378:metabolism; D023421:Models, Animal; D053758:Nanoparticles / Q000627:therapeutic use*; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D010108:Oxyhemoglobins / Q000378:metabolism / Q000627:therapeutic use*
D001704:Biopolymers; D001802:Blood Substitutes; D004337:Drug Carriers; D006454:Hemoglobins; D010108:Oxyhemoglobins; D008706:Methemoglobin; D010100:Oxygen