title: Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced solid tumors who have failed standard therapy.
abstract: OBJECTIVE
  To establish the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), safety and recommended Phase II dose of ixabepilone, administered weekly as an intravenous (IV) infusion to patients with solid tumors who have failed standard therapy.
  
  
  METHODS
  This was an open-label, single-arm, Phase I, dose-escalation study.
  
  
  RESULTS
  The MTD of ixabepilone [30-min, weekly IV infusion on a 21-day schedule (N = 33)] was established at 25 mg/m(2). Grade 3 fatigue was the DLT in 2/4 patients treated at 30 mg/m(2). Ixabepilone was well tolerated at the MTD. Myelosuppression was rare, with no Grade 3/4 neutropenia. Due to the potential for cumulative neurotoxicity, the protocol was amended to a 1-h infusion, weekly for 3 weeks with a 1-week break. No DLT occurred at starting doses of 15, 20 and 25 mg/m(2) on this modified schedule (N = 51), although overall toxicity was less at 15 and 20 mg/m(2) than 25 mg/m(2). Five patients (2 on the 30-min/21-day schedule and 3 on the 60-min/28-day schedule) achieved durable objective partial responses across a variety of tumor types.
  
  
  CONCLUSIONS
  Ixabepilone had an acceptable safety profile at the MTD of 25 mg/m(2) (as a 30-min weekly infusion on a continuous 21-day schedule) and at 20 mg/m(2) (as a 1-h weekly infusion on a modified 28-day schedule). The clinical activity and acceptable tolerability profile warrant further single- or combination-agent evaluation.
authors.affiliation: Institut Jules Bordet, Medical Oncology Clinic, Brussels, Belgium. ahmad.awada@bordet.be
authors.forename: Ahmad
authors.initials: A
authors.lastname: Awada
authors.forename: Martine J
authors.initials: MJ
authors.lastname: Piccart
authors.forename: Suzanne F
authors.initials: SF
authors.lastname: Jones
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Peck
authors.forename: Thierry
authors.initials: T
authors.lastname: Gil
authors.forename: David
authors.initials: D
authors.lastname: Lebwohl
authors.forename: Chi-Yuan
authors.initials: CY
authors.lastname: Wu
authors.forename: Howard A
authors.initials: HA
authors.lastname: Burris
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D034261:Epothilones / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; C430592:ixabepilone