title: Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescence.
abstract: Neuropsychological deficits in the executive system are major sources of morbidity in individuals with attention-deficit/hyperactivity disorder (ADHD). We conducted a 5-year longitudinal study of girls with (N = 140) and without (N = 122) ADHD, aged 6-18 years at baseline. Neuropsychological functioning was assessed using standard neuropsychological testing assessing executive functions (EFs). Girls with ADHD were significantly more impaired than controls in all neuropsychological domains except set shifting. Despite variability in the stability of individual domains of EFs, the majority (79%) of girls with ADHD that met the categorical definition of executive function deficits (EFDs, defined as two or more EF tasks impaired) at baseline continued to have EFDs at the five-year followup. These findings document the stability of EFDs in girls with ADHD from childhood into adolescence.
authors.affiliation: Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. jbiederman@partners.org
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
authors.forename: Carter R
authors.initials: CR
authors.lastname: Petty
authors.forename: Alysa E
authors.initials: AE
authors.lastname: Doyle
authors.forename: Thomas
authors.initials: T
authors.lastname: Spencer
authors.forename: Carly S
authors.initials: CS
authors.lastname: Henderson
authors.forename: Bryan
authors.initials: B
authors.lastname: Marion
authors.forename: Ronna
authors.initials: R
authors.lastname: Fried
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011340:Problem Solving; D011446:Prospective Studies; D011594:Psychometrics; D011930:Reaction Time; D012016:Reference Values; D012737:Sex Factors; D014888:Wechsler Scales / Q000706:statistics & numerical data