Successful treatment with plasma exchange in adult-onset Still's disease with hyper-IL-18-naemia and hyperallergic state.
Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.
Ito
Tomoki
T
First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan.
Ozaki
Yoshio
Y
Shimamoto
Keiko
K
Amuro
Hideki
H
Tanijiri
Tsutomu
T
Yokoi
Takashi
T
Son
Yonsu
Y
Tajima
Kenichirou
K
Fukuhara
Shirou
S
D000328:Adult; D004342:Drug Hypersensitivity / Q000150:complications / Q000628:therapy*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D020382:Interleukin-18 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010951:Plasma Exchange; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000628:therapy*
C508600:IL6 protein, human; D020382:Interleukin-18; D015850:Interleukin-6; D007371:Interferon-gamma