Accumulation of Ade(+) reversions in isoauxotrophic strains ofSaccharomyces cerevisioe allelic inRAD6 during adenine starvation.
A comparative method based on an analysis of accumulation of starvation-induced Ade(+) reversions and cell death during adenine starvation was developed and exploited for estimating the role ofRAD6 in the starvation-induced reversions. It was shown that inactivation ofRAD6 function inSaccharomyces cerevisioe markedly enhances the accumulation of Ade(+) reversions, and therefore it is likely that this gene is taking part in maintaining the low level of starvation-induced mutations in yeast cells.
Storchová
Z
Z
Department of Genetics and Microbiology, Faculty of Science, Charles University, 128 44, Prague, Czech Republic.
Rojas Gil
A P
AP
Janderová
B
B
Vlasák
J
J
Vondrejs
V
V