Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals.
Homeobox genes are an evolutionarily conserved class of transcription factors that are key regulators during developmental processes such as regional specification, patterning, and differentiation. In this review, we summarize the expression pattern, loss- and/or gain-of-function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages.
Duverger
Olivier
O
Developmental Skin Biology Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA.
Morasso
Maria I
MI
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D002454:Cell Differentiation / Q000502:physiology; D004475:Ectoderm / Q000033:anatomy & histology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D018859:Hair Follicle / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D042361:Mammary Glands, Human / Q000033:anatomy & histology / Q000254:growth & development*; D009024:Morphogenesis / Q000235:genetics*; D009154:Mutation; D009262:Nails / Q000254:growth & development / Q000502:physiology; D014070:Tooth / Q000254:growth & development* / Q000502:physiology