title: Model-based identification of PEEP titrations during different volemic levels.
abstract: A cardiovascular system (CVS) model has previously been validated in simulated cardiac and circulatory disease states. It has also been shown to accurately capture all main hemodynamic trends in a porcine model of pulmonary embolism. In this research, a slightly extended CVS model and parameter identification process are presented and validated in a porcine experiment of positive end-expiratory pressure (PEEP) titrations at different volemic levels. The model is extended to more physiologically represent the separation of venous and arterial circulation. Errors for the identified model are within 5% when re-simulated and compared to clinical data. All identified parameter trends match clinically expected changes. This work represents another clinical validation of the underlying fundamental CVS model, and the methods and approach of using them for cardiovascular diagnosis in critical care.
authors.affiliation: Centre for Bioengineering, University of Canterbury, Christchurch, New Zealand. cst45@student.canterbury.ac.nz
authors.forename: C
authors.initials: C
authors.lastname: Starfinger
authors.forename: J G
authors.initials: JG
authors.lastname: Chase
authors.forename: C E
authors.initials: CE
authors.lastname: Hann
authors.forename: G M
authors.initials: GM
authors.lastname: Shaw
authors.forename: P
authors.initials: P
authors.lastname: Lambert
authors.forename: B W
authors.initials: BW
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Sloth
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: S
authors.initials: S
authors.lastname: Andreassen
authors.forename: S
authors.initials: S
authors.lastname: Rees
mesh_terms: D000465:Algorithms; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D020000:Decision Support Systems, Clinical; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D011175:Positive-Pressure Respiration / Q000379:methods*; D013552:Swine; D013990:Tidal Volume / Q000502:physiology