Application of LC/MS and related techniques to high-throughput drug discovery.
The broad coordinated implementation of common platform technologies, such as LC/MS, can be a key factor in attaining increased throughput, sensitivity and data quality for pharmaceutical discovery. These platform technologies are the key tools that Medicinal Analytical Chemists rely upon to address the ever-changing needs of a drug discovery team. Despite the recent advances in key areas of sensitivity and speed for LC/MS, additional progress to address these never-ending analytical problems can be anticipated. This review will highlight current status and future advances for the applications of LC/MS and related techniques to high-throughput drug discovery.
Espada
Alfonso
A
Analytical Technologies Department, Centro de Investigación Lilly S.A., Avenida de la Industria 30, Alcobendas, Madrid, Spain. espada_alfonso@lilly.com
Molina-Martin
Manuel
M
Dage
Jeffrey
J
Kuo
Ming-Shang
MS
D002853:Chromatography, Liquid; D015195:Drug Design; D013058:Mass Spectrometry