Neuroprotective effect of ultra-low doses of antibodies against S100 protein in neuroblastoma culture during oxygen and glucose deprivation.
Antibodies against S100 protein applied in high and ultra-high dilutions possess neuroprotective activity and maintain survival of neuroblastoma C-1300 cells under conditions of oxygen and glucose deprivation. The examined antibody preparations stimulated differentiation in neuroblastoma culture thereby demonstrating pronounced neurotrophic activity.
Pankova
T M
TM
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Starostina
M V
MV
Shtark
M B
MB
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002470:Cell Survival; D005947:Glucose / Q000172:deficiency*; D006801:Humans; D000860:Hypoxia; D051379:Mice; D009447:Neuroblastoma; D018696:Neuroprotective Agents / Q000378:metabolism*; D009418:S100 Proteins / Q000276:immunology*
D000906:Antibodies; D018696:Neuroprotective Agents; D009418:S100 Proteins; D005947:Glucose