Endocytic transport of integrins during cell migration and invasion.
Early studies describing the endocytic-exocytic cycling of integrins prompted proposals that this process regulates cell migration. However, it is only relatively recently that more detailed descriptions of the molecular machinery responsible for directing integrin trafficking have enabled us to properly address the role of these events during the various modes of cell migration. Here, we review recent advances in our understanding of the protein complexes and signallosomes controlling integrin trafficking, and we describe how these influence cell migration and signalling events downstream of integrin engagement. Furthermore, we consider recent evidence for integrin trafficking during the invasive migration of cancer cells through 3D microenvironments, and conclude with a discussion of the use of novel photoactivatable integrin probes to visualize these processes.
Caswell
Patrick
P
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
Norman
Jim
J
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D019281:Dimerization; D004705:Endocytosis; D005089:Exocytosis; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008027:Light; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D011506:Proteins / Q000737:chemistry; D015398:Signal Transduction
D016023:Integrins; D011506:Proteins