The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.
BACKGROUND
Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.


METHODS
Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.


RESULTS
The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).


CONCLUSIONS
A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis.
Hsu
Ping-I
PI
Department of Internal Medicine, Kaohsiung Veterans General Hospital and National Yang-Ming University, Kaohsiung, Taiwan.
Huang
Ming-Shyan
MS
Chen
Hui-Chun
HC
Hsu
Ping-Ning
PN
Lai
Tsung-Ching
TC
Wang
Jui-Ling
JL
Lo
Gin-Ho
GH
Lai
Kwok-Hung
KH
Tseng
Ching-Jiunn
CJ
Hsiao
Michael
M
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D017310:Annexin A7 / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D017310:Annexin A7