Longitudinal imaging in dementia.
Dementia represents one of the major public health problems facing ageing populations, with 20% of those over 80 years of age suffering from this disorder. The advent of therapeutic agents has brought about an increasing demand for a more accurate and earlier diagnosis, and the value of neuroimaging in improving the diagnostic process is becoming widely accepted. Neuroimaging assessments may add weight to a diagnosis of neurodegeneration as opposed to healthy ageing, improve the differential diagnosis, aid in the prediction of conversion to dementia in individuals at a higher risk of developing the disorder, track disease progression and provide an outcome measure for assessment of drug efficacy.
Scahill
R I
RI
Dementia Research Centre, 8-11 Queen Square, London WC1N 3BG, UK. rscahill@dementia.ion.ucl.ac.uk
Fox
N C
NC
D000544:Alzheimer Disease / Q000473:pathology; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods