Inhibitory effect against Akt of cyclic dipeptides isolated from Bacillus sp.
Among thirteen strains of the genus Bacillus isolated from Shrimp-jeotkal in our laboratory, a strain BA34 showing good antifungal activity against Phytophthora infestans in a previous experiment was tested for the inhibitory effect against Akt, protein kinase B. Since Akt is known to play an important role in controlling apoptosis, its inhibitors can be used as potential apoptosis-inducing agents in the treatment of cancer. Two active compounds were isolated and their structures were determined. They have similar structures, despite showing different inhibitory effects. In order to elucidate the reasons for these different effects, three-dimensional studies were carried out.
Hong
Sungwon
S
Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea.
Moon
Byoung-Ho
BH
Yong
Yeonjoong
Y
Shin
Soon Young
SY
Lee
Young Han
YH
Lim
Yoongho
Y
D000818:Animals; D001407:Bacillus / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D045744:Cell Line, Tumor; D033364:Decapoda / Q000382:microbiology*; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004151:Dipeptides; D004791:Enzyme Inhibitors; D051057:Proto-Oncogene Proteins c-akt