The effect of paclitaxel on rats following benzo(a)pyrene treatment.
OBJECTIVE
To observe the effects of paclitaxel on rats that received benzo(a)pyrene.


METHODS
In this study, 45 male Sprague-Dawley rats aged 2-month-old were used, which were housed at the Medical Biology Department of Eskisehir Osmangazi University, Eskisehir, Turkey in 2006. Urine, blood, liver, and kidney tissue samples of Sprague Dawley rats treated with benzo(a)pyrene and paclitaxel were examined in our study. Biochemical data were evaluated on urine and blood samples, and liver and kidney tissue samples were investigated by light microscopy.


RESULTS
Superoxide dismutase, catalase activities, and malondialdehyde values in the group which received benzo(a)pyrene were significantly different than the control, and most of these parameters came close to control values in the group that received paclitaxel following benzo(a)pyrene application. Histological appearances of the samples of all rats also supported the biochemical results.


CONCLUSIONS
The present study indicated that liver and kidney structures damaged by benzo(a)pyrene may be restored by paclitaxel.
Cosan
Didem
D
Department of Medical Biology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey. dcosan@ogu.edu.tr
Basaran
Ayse
A
Degirmenci
Irfan
I
Gunes
Hasan V
HV
Aral
Erinc
E
D000704:Analysis of Variance; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017239:Paclitaxel / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D001564:Benzo(a)pyrene; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D017239:Paclitaxel