title: Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.
abstract: Neurodegeneration and brain edema are hallmarks of human malignant brain tumors. Here we show that genetic or pharmacological inhibition of the glutamate transporter xCT (X(c-) system, encoded by SLC7a11) in vivo leads to abrogated neurodegeneration, attenuated perifocal edema and prolonged survival. These results show a crucial role for xCT in glioma-induced neurodegeneration and brain edema, corroborating the concept that edema formation may be in part a consequence of peritumoral cell death.
authors.affiliation: Brain Research Institute, Swiss Federal Institute of Technology & University Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
authors.forename: Nicolai E
authors.initials: NE
authors.lastname: Savaskan
authors.forename: Alexandra
authors.initials: A
authors.lastname: Heckel
authors.forename: Eric
authors.initials: E
authors.lastname: Hahnen
authors.forename: Tobias
authors.initials: T
authors.lastname: Engelhorn
authors.forename: Arnd
authors.initials: A
authors.lastname: Doerfler
authors.forename: Oliver
authors.initials: O
authors.lastname: Ganslandt
authors.forename: Christopher
authors.initials: C
authors.lastname: Nimsky
authors.forename: Michael
authors.initials: M
authors.lastname: Buchfelder
authors.forename: Ilker Y
authors.initials: IY
authors.lastname: Eyüpoglu
mesh_terms: D027182:Amino Acid Transport System y+ / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D001929:Brain Edema / Q000473:pathology*; D016022:Case-Control Studies; D045744:Cell Line, Tumor; D020868:Gene Silencing; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism*
chemical_list: D027182:Amino Acid Transport System y+; D034741:RNA, Small Interfering; C118895:SLC7A11 protein, human