title: Patient reported outcomes and analgesia use in osteoarthritis of the knee.
abstract: OBJECTIVE
  Non-opioid analgesics (NOAs) are widely used to palliate osteoarthritis (OA) pain, however, their role in health-related quality of life (HRQoL) in OA has not been well studied. Here, we assess the relationship of pain, physical function, and HRQoL to NOA use in symptomatic knee OA.
  
  
  METHODS
  NOA dose, pain, physical function, and HRQoL were evaluated longitudinally over 1 year in medial knee OA. Doses provided by subjects' weekly medication diaries were normalized to equi-analgesic ibuprofen-equivalents (IEs). Descriptive analyses at baseline, 1.5, and 12 months, and non-parametric comparisons of NOA with pain, physical function, and HRQoL at 1.5 months and over 12 months were performed.
  
  
  RESULTS
  Seventy-one subjects (19 males and 52 females; mean 57+/-10.5 years) used an overall median of 300 mg/week of IE. Twenty-five subjects reported no analgesic use during the study; of the 46 subjects that reported NOA use, the median intake was 1325 mg/week IE. Whereas age, Physical Functioning (PF) and HRQoL were predictive of NOA dose both at 1.5 months and during the entire study, pain level was not. The median NOA dose declined over 12 months (P=0.02), however, the change was not associated with changes in PF, HRQoL or pain.
  
  
  CONCLUSIONS
  Greater age and worse physical function and HRQoL, but not pain severity, are predictive of NOA use in symptomatic knee OA. Longitudinally, NOA use does not change as a function of pain. These data suggest that pain is not the primary determinant of NOA use over time among OA patients.
authors.affiliation: Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: S
authors.initials: S
authors.lastname: Mody
authors.forename: M
authors.initials: M
authors.lastname: Jolly
authors.forename: M J
authors.initials: MJ
authors.lastname: Kwasny
authors.forename: J A
authors.initials: JA
authors.lastname: Block
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D018771:Arthralgia / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000503:physiopathology; D010147:Pain Measurement; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic