Development and characterization of an equine infectious anemia virus Env-pseudotyped reporter virus.
We developed a replication-defective reporter virus pseudotyped with the envelope glycoprotein of equine infectious anemia virus (EIAV). The in vitro host range and neutralization phenotype of EIAV Env-pseudotyped virus were similar to those of replication-competent virus. An EIAV Env pseudovirus will improve antigenic characterization of viral variants and evaluation of lentivirus vaccines.
Tallmadge
R L
RL
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99163, USA.
Brindley
M A
MA
Salmans
J
J
Mealey
R H
RH
Maury
W
W
Carpenter
S
S
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002460:Cell Line; D004859:Equine Infectious Anemia / Q000276:immunology* / Q000821:virology; D005818:Genetic Engineering; D006736:Horses; D004860:Infectious Anemia Virus, Equine / Q000276:immunology* / Q000378:metabolism; D009500:Neutralization Tests; D014759:Viral Envelope Proteins / Q000276:immunology* / Q000378:metabolism; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014759:Viral Envelope Proteins; D014765:Viral Vaccines