title: Efficacy of intravitreal ceftazidime in acute postoperative endophthalmitis.
abstract: OBJECTIVE
  To assess the efficacy of intravitreal ceftazidime in acute postoperative endophthalmitis.
  
  
  METHODS
  Quasi experimental study.
  
  
  METHODS
  Department of Ophthalmology Unit I, Eye Hospital, Liaquat University of Medical and Health Sciences, Hyderabad, from November 2004 to November 2006.
  
  
  METHODS
  Twenty-one eyes of 21 patients of acute postoperative endophthalmitis were treated with intravitreal antibiotic ceftazidime. The inclusion criteria of the patients was the clinical diagnosis of acute postoperative endophthalmitis within 15 days of postoperative period with visual acuity better than or equal to hand movement close to face. After enrollment, vitreous tap was carried out in all cases followed by intravitreal ceftazidime injection. The outcome was measured in terms of clinical resolution of endophthalmitis and postresolution best corrected visual acuity. Mean of difference was tested by paired t-test.
  
  
  RESULTS
  Nineteen eyes (90.5%) responded to intravitreal ceftazidime therapy alone, while an additional pars plana vitrectomy was required in one eye. Sixteen eyes (84%) retained a visual acuity of 6/60 or better at 3 months after the initiation of the therapy (p<0.001). Retinal detachment developed in one eye receiving intravitreal therapy.
  
  
  CONCLUSIONS
  Ceftazidime was effective as intravitreal therapy for the management of acute postoperative endophthalmitis.
authors.affiliation: Department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh. amnarsani@hotmail.com
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Narsani
authors.forename: Shafi Muhammad
authors.initials: SM
authors.lastname: Jatoi
authors.forename: Siddiqa
authors.initials: S
authors.lastname: Gul
authors.forename: Syed Asher
authors.initials: SA
authors.lastname: Dabir
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002387:Cataract Extraction / Q000009:adverse effects; D002442:Ceftazidime / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime