Cracking the RNA polymerase II CTD code.
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA polymerase. This unusual structure provides a docking platform for factors involved in various co-transcriptional events. Recruitment of the appropriate factors at different stages of the transcription cycle is achieved through changing patterns of post-translational modification of the CTD repeats, which create a readable 'code'. A new phosphorylation mark both expands the CTD code and provides the first example of a CTD signal read in a gene type-specific manner. How and when is the code written and read? How does it contribute to transcription and coordinate RNA processing?
Egloff
Sylvain
S
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Murphy
Shona
S
D020816:Amino Acid Motifs / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D004722:Endoribonucleases / Q000378:metabolism; D042421:Histone Code / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010445:Peptide Elongation Factors / Q000378:metabolism; D011485:Protein Binding; D011499:Protein Processing, Post-Translational / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000235:genetics; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D010445:Peptide Elongation Factors; D012319:RNA Polymerase II; D004722:Endoribonucleases; C051012:splicing endonuclease