Molecular mechanisms of inflammatory bone damage: emerging targets for therapy.
Chronic inflammatory bone diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis and periodontal disease, demonstrate the major impact of chronic inflammation on both bone metabolism and bone architecture. During the past decade, scientists have gained increasing insight into the link between inflammation and bone. As a result of new discoveries about the molecular mechanisms of inflammatory bone loss, several molecules have been identified that are attractive and novel targets for the treatment of inflammatory bone loss. These novel therapeutic approaches include anti-tumor necrosis factor (TNF)-alpha blocking agents, neutralizing antibodies against certain pro-inflammatory cytokines, such as interleukin (IL)-6 and IL-17, and a set of other promising targets that still require extensive research, such as the Wnt signaling network.
Herman
Sonja
S
Department of Internal Medicine 3, University of Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany.
Krönke
Gerhard
G
Schett
Georg
G
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology / Q000628:therapy; D001847:Bone Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D001842:Bone and Bones / Q000276:immunology / Q000473:pathology; D006801:Humans; D007249:Inflammation; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology / Q000473:pathology / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology; D051153:Wnt Proteins / Q000276:immunology; D000093242:Interleukin-6 Inhibitors
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D020381:Interleukin-17; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D051153:Wnt Proteins; D000093242:Interleukin-6 Inhibitors