[Heparin-binding epidermal growth factor (HB-EGF): myth or reality?].
Heparin-Binding Epidermal Growth Factor (HB-EGF) is growth factor member of EGF family that stimulate differentiation and growth. HB-EGF was initially identified as a secreted product of human macrophage-like cells, it is sinthetized as a transmembrana protein; proHB-EGF; that is shed by specific metalloproteases, releasing soluble growth factor(sHB-EGF). It exerts biological activity trough activation of the EGFR. sHB-EGF is implicated in diverse biological processes: angiogenesis, shin wound, blastocysts implantation, atherosclerosis, tumor formation moreover it acts as the Diphtheria Toxin (DT) receptor. HB-EGF It's an important molecule because could be a novel targeting for cancer and atherosclerosis therapy.
Scuderi
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Dipartimento di Medicina Interna e Patologie Sistemiche, U.O. Medicina Interna A. Francaviglia Policlinico Università di Catania, Italia. rosarioscuderi@virgilio.it
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D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic; D004351:Drug Resistance / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology; D066246:ErbB Receptors / Q000502:physiology; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D051379:Mice; D008938:Mitosis / Q000502:physiology; D009362:Neoplasm Metastasis; D018919:Neovascularization, Physiologic / Q000502:physiology; D017434:Protein Structure, Tertiary; D051381:Rats; D066247:Receptor, ErbB-4; D012038:Regeneration / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
C587883:HBEGF protein, human; C587884:Hbegf protein, mouse; C587885:Hbegf protein, rat; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; C587689:ERBB4 protein, human; D066246:ErbB Receptors; C587690:Erbb4 protein, mouse; C587691:Erbb4 protein, rat; D066247:Receptor, ErbB-4