title: Efficacy of a single application of a 12.5% pyriprole topical solution against laboratory infestations with ticks (Ixodes ricinus, Dermacentor reticulatus, and Rhipicephalus sanguineus) on dogs.
abstract: In three separate studies, the efficacy of a single treatment with a 12.5% pyriprole spot-on solution was investigated against induced infestation with Ixodes ricinus, Dermacentor reticulatus and Rhipicephalus sanguineus on dogs (both sexes; Beagles in Studies 1 and 2, mixed-breed in Study 3). For each tick species, one group of 8 dogs left untreated (Studies 1 and 2) or treated with a placebo solution (Study 3) was compared with another group treated once with the spot-on solution at a dose rate of at least 12.5mg/kg. The dogs were infested with 50 unfed adult ticks of the respective species at various time-points before and after treatment and the surviving attached and unattached ticks were recorded 48 h after re-infestation. For each tick species, efficacy was assessed for each time-point and cumulatively for the whole evaluation period. The dogs were submitted to general health observations and clinical assessments during the study. Efficacy against I. ricinus and R. sanguineus was 100% during the whole evaluation period of 30 days. For D. reticulatus cumulative efficacy for the 30 days after treatment was 98.9%. The product was well tolerated by all the animals.
authors.affiliation: Novartis Animal Health Inc., Basel, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Schuele
authors.forename: S
authors.initials: S
authors.lastname: Barnett
authors.forename: B
authors.initials: B
authors.lastname: Bapst
authors.forename: T
authors.initials: T
authors.lastname: Cavaliero
authors.forename: L
authors.initials: L
authors.lastname: Luempert
authors.forename: G
authors.initials: G
authors.lastname: Strehlau
authors.forename: D R
authors.initials: DR
authors.lastname: Young
authors.forename: C
authors.initials: C
authors.lastname: Moran
authors.forename: P
authors.initials: P
authors.lastname: Junquera
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology*; D026863:Ixodidae / Q000187:drug effects*; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D007306:Insecticides; D011720:Pyrazoles; D011725:Pyridines; C532951:pyriprole