Effect of bone mineral with or without collagen membrane in ridge dehiscence defects following premolar extraction.
BACKGROUND
The purpose of this investigation was to evaluate the regenerative response to deproteinized porous bovine bone mineral (BM) when used alone or in combination with a bioresorbable porcine-derived bilayer collagen membrane (CM) for alveolar ridge augmentation in dogs.


METHODS
The mandibular premolars were extracted unilaterally and three ridge defects were induced in six mongrel dogs. Each defect site was randomly assigned to one of the following treatment groups: BM alone (group A), BM in combination with CM (group B), or neither membrane nor bone graft, which served as a control (group C). No adverse events occurred during the experimental period. Dental computed tomography (CT) scans were taken after postoperative periods of 8 and 16 weeks.


RESULTS
The percentage of CT-derived bone density in groups A and B was significantly different from that of group C (p < 0.01) at 8 and 16 weeks. The percentage of CT-derived bone density of the dogs in Group B was significantly higher than that of those in group A at 8 and 16 weeks (p < 0.01). Gross evaluation of the 3-dimensional CT reconstruction image of the canine mandibles after 16 weeks of implantation showed that group B had the greatest amount of bone augmentation and excellent thickness of the buccal aspect of the alveolar ridge.


CONCLUSIONS
These results suggest that BM leads to more successful bone regeneration for guided bone regeneration procedures, especially in conjunction with the use of a CM as a barrier in order to promote the regeneration of canine alveolar ridge defects.
Kim
Myounghwan
M
College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Kim
Joong-Hyun
JH
Lee
Jae Yeong
JY
Cho
Kirae
K
Kang
Seong Soo
SS
Kim
Gonhyung
G
Lee
Min Jae
MJ
Choi
Seok Hwa
SH
D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001641:Bicuspid / Q000601:surgery*; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D008297:Male; D008567:Membranes, Artificial; D013223:Statistics as Topic; D013552:Swine; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D018786:Bone Substitutes; D008567:Membranes, Artificial; D003094:Collagen