New targets for the treatment of vascular diseases and diabetes.
This symposium was organized by Dan Flynn (Monsanto Life Sciences, USA) and Timothy M Willson (Glaxo Wellcome, USA). PPARs (peroxisome proliferator-activated receptors), are nuclear hormone receptors that govern glucose and lipid homeostasis. There are several subtypes of receptors that share activation by unsaturated fatty acids and work in combination with retinoic acid receptors (RXR), which were a topic covered in an earlier symposium. Two classes of chemistry were discussed at the symposium: (i) thiazolidinediones, that interact directly with PPARs and alter lipid metabolism; and, (ii) benzothiepines or benzothiazepines, that inhibit the ileal bile acid transporter (IBAT) and reduce cholesterol levels by increasing bile acid excretion.
Schloss
J V
JV
Department of Medicinal Chemistry, University of Kansas, 4070 Malott Hall, Lawrence, KS 66045, USA. schloss@kuhub.cc.ukanss.edu