title: Chronic viral hepatitis C, oxidative stress and the coagulation/fibrinolysis system in haemodialysis patients.
abstract: BACKGROUND
  The aim of the present study was to establish whether the presence of chronic viral hepatitis (PVH) could be implicated in the elevation of oxidative stress (SOX) and haemostasis system in haemodialysis (HD) patients.
  
  
  METHODS
  In HD patients with and without PVH and in controls we compared the markers of: coagulation pathway- tissue factor (TF) and its inhibitor (TFPI), prothrombin fragment F (1+2) (F (1+2)); fibrinolysis: tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA) and its soluble receptor (suPAR), plasminogen activator inhibitor 1 (PAI-1), plasmin/antiplasmin complexes (PAP); and a marker of SOX-Cu/Zn superoxide dismutase (Cu/Zn SOD) levels.
  
  
  RESULTS
  Patients, particularly those with PVH, showed a significant increase in the markers of the coagulation, fibrinolysis and oxidative status as compared to controls. All parameters of coagulation/fibrinolysis system were directly associated with the PVH and Cu/Zn SOD levels, and there was a relationship between the PVH and Cu/Zn SOD levels. Multivariable analysis showed that PVH and increased SOX were identified as independent variables significantly associated with the disturbances of coagulation/fibrinolysis system in these patients.
  
  
  CONCLUSIONS
  We concluded that PVH is a novel determinant of the increased oxidative stress as well as the disturbances of coagulation/fibrinolysis system in haemodialysis patients.
authors.affiliation: Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland. krystynapawlak@poczta.onet.pl
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pawlak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zolbach
authors.forename: Jacek
authors.initials: J
authors.lastname: Borawski
authors.forename: Michal
authors.initials: M
authors.lastname: Mysliwiec
authors.forename: Oksana
authors.initials: O
authors.lastname: Kovalchuk
authors.forename: Lech
authors.initials: L
authors.lastname: Chyczewski
authors.forename: Dariusz
authors.initials: D
authors.lastname: Pawlak
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D006435:Renal Dialysis; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D013482:Superoxide Dismutase