title: Risk factors for Alzheimer dementia in a community-based birth cohort at the age of 75 years.
abstract: BACKGROUND
  Few prospective community-based cohort studies have so far concentrated specifically on the risk factors for Alzheimer dementia (AD) with onset after the age of 75 years.
  
  
  METHODS
  We prospectively investigated a birth cohort of 585 nondemented inhabitants in the area on the East bank of the river Danube who were born between 1925 and 1926. They were investigated at the age of 75 years and followed up after 30 months. The follow-up was possible with 488 probands; 36 died, and 61 refused to participate.
  
  
  RESULTS
  In multivariate analysis an elevated risk for late-onset AD could be found for (1) history of depressive episodes (OR = 2.09; 95% CI = 1.25-3.48); (2) the epsilon 4 allele of the APOE gene (OR = 1.86; 95% CI = 1.08-3.23); (3) lower serum level of folate (OR = 0.92; 95% CI = 0.87-0.98); (4) no chronic use of nonsteroidal anti-inflammatory drugs (OR = 0.40; 95% CI = 0.20-0.81), and (5) lower education (OR = 1.43; 95% CI = 1.03-2.00).
  
  
  CONCLUSIONS
  Five risk factors for late-onset AD could be confirmed, which might be targets for preventive strategies.
authors.affiliation: Ludwig Boltzmann Institute of Aging Research, Vienna, Austria. p.fischer@wienkav.at
authors.forename: Peter
authors.initials: P
authors.lastname: Fischer
authors.forename: Sonja
authors.initials: S
authors.lastname: Zehetmayer
authors.forename: Susanne
authors.initials: S
authors.lastname: Jungwirth
authors.forename: Silvia
authors.initials: S
authors.lastname: Weissgram
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Krampla
authors.forename: Margarete
authors.initials: M
authors.lastname: Hinterberger
authors.forename: Sabine
authors.initials: S
authors.lastname: Torma
authors.forename: Michael
authors.initials: M
authors.lastname: Rainer
authors.forename: Klaus
authors.initials: K
authors.lastname: Huber
authors.forename: Selma
authors.initials: S
authors.lastname: Hoenigschnabl
authors.forename: Ellen
authors.initials: E
authors.lastname: Gelpi
authors.forename: Kurt
authors.initials: K
authors.lastname: Bauer
authors.forename: Thomas
authors.initials: T
authors.lastname: Leitha
authors.forename: Peter
authors.initials: P
authors.lastname: Bauer
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Tragl
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology*; D001317:Austria / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D012111:Residence Characteristics; D012307:Risk Factors