title: Large volume autologous plasma predonation and retransfusion in orthopedic surgical patients.
abstract: BACKGROUND
  Intraoperative washed autologous transfusion of the scavenged blood can reduce the deterioration of anemia, even during the operation with a comparatively large blood loss. On the other hand, plasma level can not be collected by this system. The preoperative donation and perioperative retransfusion of autologous plasma may reduce the plasma dilution.
  
  
  OBJECTIVE
  The influence of a large volume plasma predonation and perioperative retransfusion on the plasma protein level was investigated.
  
  
  METHODS
  Thirteen patients (63.2 +/- 13.2 yr, 70.3 +/- 12.1 kg) were examined regarding their serum protein (SP), IgG, coagulation systems, colloid osmotic pressure (COP), blood cell count before, just after, 2 h after and 7 days after the donation of 900 ml plasma by plasmapheresis with a simultaneous volume replacement. Twenty surgical patients (52.8 +/- 17.3 yr, 72.6 +/- 16.6 kg, the mean predonated autologous plasma: 2100 ml) with intra- and postoperative retransfusion of autologous plasma were examined perioperatively for SP, IgG, coagulation systems and COP. These parameters were compared with that of the predonated plasma.
  
  
  RESULTS
  All data including SP, coagulation and COP, with the exception of IgG, completely recovered within 7 days after preoperative plasmapheresis. Perioperatively, autologous washed blood transfusion system was used. The retransfused volume of autologous predonated plasma was 1740 ml on average. Although about 41 of blood on average was lost perioperatively, only one patient out of 20 patients had to be administered homologous red blood cell transfusion. The levels of most parameters, except for COP, constantly recovered in accordance with the autologous plasma transfusion. Differences in the patterns of improvement were also observed between the parameters.
  
  
  CONCLUSIONS
  A 900 ml plasma predonation can therefore be safely performed with an interval of not less than a week between the last donation and the operation. Autologous plasma retransfusion is thus considered to improve the protein levels.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Kyushu University Hospital. yoshiro@kuaccm.med.kyushu-u.ac.jp
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Sakaguchi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Inaba
authors.forename: Peter
authors.initials: P
authors.lastname: Geiger
authors.forename: Hans-Hinrich
authors.initials: HH
authors.lastname: Mehrkens
authors.forename: Shosuke
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D001798:Blood Proteins / Q000032:analysis; D001804:Blood Transfusion, Autologous / Q000379:methods*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D010949:Plasma
chemical_list: D001798:Blood Proteins; D007074:Immunoglobulin G