title: Flow cytometry and morphology analysis of bone marrow in a child with brucellosis and hematologic manifestations.
abstract: Constitutional symptoms and pancytopenia are occasionally the initial presentation of pediatric brucellosis. Therefore, in endemic areas, in children with pancytopenia, both brucellosis and malignancy should be included in the deferential diagnosis. We report here a child with pancytopenia and hepatosplenomegaly as manifestations of brucellosis in whom bone marrow morphology and flow cytometry data revealed hemophagocytosis, left shift in myeloid cells and activation changes in antigenic properties of T and B lymphocytes and monocytes. The patient had an uneventful and complete recovery after appropriate antibiotic therapy. Our report demonstrates that bone marrow and flow cytometry findings in children with brucellosis may include significant reactive changes in hematopoiesis.
authors.affiliation: Pediatric Emergency Department, Soroka University Medical Center, Beer-Sheva, Israel. broides@bgu.ac.il
authors.forename: Arnon
authors.initials: A
authors.lastname: Broides
authors.forename: George
authors.initials: G
authors.lastname: Shubinsky
authors.forename: Tikva
authors.initials: T
authors.lastname: Yermiahu
authors.forename: Abed
authors.initials: A
authors.lastname: Abu-Quider
authors.forename: Joseph
authors.initials: J
authors.lastname: Press
authors.forename: Asher
authors.initials: A
authors.lastname: Moser
mesh_terms: D015703:Antigens, CD / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology*; D002006:Brucellosis / Q000150:complications* / Q000473:pathology*; D002648:Child; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood; D006529:Hepatomegaly / Q000209:etiology / Q000276:immunology; D006801:Humans; D010198:Pancytopenia / Q000209:etiology* / Q000276:immunology; D013163:Splenomegaly / Q000209:etiology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D006684:HLA-DR Antigens