An overview and expert opinion on the use of alprostadil in the treatment of sexual dysfunction.
BACKGROUND
Erectile dysfunction is a disease affecting millions of men over the age of 40. Alprostadil, a synthetic form of prostaglandin E(1), was introduced almost three decades ago, and is today considered an alternative treatment for erectile dysfunction.


OBJECTIVE
The purpose of this article is to educate the reader on the mechanism of action of alprostadil and outline its indications, side effects, and compare it with other pharmacologic therapies for erectile dysfunction. Future horizons for its use are also discussed and an expert opinion on the use of alprostadil is offered.


METHODS
The historical and recent literature was reviewed to provide a concise description.


CONCLUSIONS
Alprostadil is safe and effective in the treatment of erectile dysfunction, mainly as second-line therapy for patients in which oral treatment is contraindicated or ineffective.
Costabile
Raymond A
RA
University of Virginia, Department of Urology, UVA Medical Center, Box 800422, Charlottesville, VA 22908, USA. rac2b@virginia.edu
Mammen
Tony
T
Hwang
Kathleen
K
D000367:Age Factors; D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D018849:Controlled Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D014665:Vasodilator Agents; D000527:Alprostadil