title: Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.
abstract: The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer and other diseases, which, if taken into account, may substantially increase estimates of gain in life expectancy resulting from cancer eradication. We also used the Multiple Causes of Death (MCD) data to evaluate correlations among mortalities from cancer and other major disorders including heart disease, stroke, diabetes, Alzheimer's, Parkinson's diseases, and asthma. Our analyses revealed significant negative correlations between cancer and other diseases suggesting stronger population effects of cancer eradication. Possible mechanisms of the observed dependencies and emerging perspectives of using dependent competing risks models for evaluating the effects of reduction of mortality from cancer on life expectancy are discussed.
authors.affiliation: Center for Population Health and Aging, Duke University, Durham, NC 27708-0408, USA. aiy@duke.edu
authors.forename: Anatoli I
authors.initials: AI
authors.lastname: Yashin
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Ukraintseva
authors.forename: Igor V
authors.initials: IV
authors.lastname: Akushevich
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Arbeev
authors.forename: Alexander
authors.initials: A
authors.lastname: Kulminski
authors.forename: Lucy
authors.initials: L
authors.lastname: Akushevich
mesh_terms: D000368:Aged; D000375:Aging; D000818:Animals; D002423:Cause of Death; D002908:Chronic Disease / Q000401:mortality*; D006801:Humans; D008017:Life Expectancy / Q000639:trends*; D015233:Models, Statistical; D009369:Neoplasms / Q000401:mortality*; D012307:Risk Factors