title: Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain.
abstract: Conjugated Linoleic Acid (CLA) is fatty acid found endogenously in food sources that prevents new tumor development and reduces the growth of existing tumors in laboratory animals. CLA exerts its anti-carcinogenic effect by reducing VEGF and bFGF serum levels and by blocking flk-1 receptors, thereby inhibiting vascular growth critical to tumor growth and survival. Although the ability of CLA to inhibit angiogenesis in the peripheral nervous system is well characterized, it remains unknown whether CLA also affects vascular morphology in the central nervous system. Therefore, in the present study, exercising and sedentary animals received either standard rat chow or a specially formulated diet consisting of 0.5% CLA for 24 days. The brains were then examined to determine the extent of vascular growth in the cerebellum, a region known to exhibit robust exercise-induced angiogenesis. Our results indicate that CLA administration significantly reduces angiogenesis in the cerebellum. This study is the first to demonstrate the anti-angiogenic effect of CLA in the brain, and suggests that CLA be explored as a therapeutic treatment for cancer and tumors in the brain.
authors.affiliation: University of Texas at San Antonio, Department of Biology, 6900 North Loop 1604 West, San Antonio, TX 78249, USA.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Sikorski
authors.forename: Nathan
authors.initials: N
authors.lastname: Hebert
authors.forename: Rodney A
authors.initials: RA
authors.lastname: Swain
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001930:Brain Injuries / Q000150:complications / Q000178:diet therapy / Q000473:pathology; D002531:Cerebellum / Q000033:anatomy & histology* / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D019787:Linoleic Acid / Q000008:administration & dosage*; D008124:Locomotion / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000178:diet therapy* / Q000209:etiology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D020533:Angiogenesis Inhibitors; D019787:Linoleic Acid