Constituents from Hoya parasitica and their cell growth inhibitory activity.
An androstanoid, hoyasterone (1), a sesquiterpene, 15-bulnesolic acid (2), and a phenolic compound, 1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol (3), together with a known triterpene, dihydrocanaric acid, were isolated from Hoya parasitica. Structures were elucidated by 1 D and 2 D NMR and mass spectroscopic analysis. Among the isolated compounds, only dihydrocanaric acid exhibited growth inhibitory activity against both HeLa and SW480 cells.
Sadhu
Samir Kumar
SK
Graduate School of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan.
Khatun
Amina
A
Ohtsuki
Takashi
T
Ishibashi
Masami
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic