title: A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.
abstract: Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis >or=50% or previous myocardial infarction and 232 controls without documented coronary artery disease. Ligase detection reaction was performed to detect two SNPs. After adjustment of clinical parameters, significant associations were identified for the rs2383207 and rs10757278 SNPs, with A/G and G/G genetypes at rs10757278 and G/G genetype carriers at rs2383207 having a higher risk of early-onset coronary artery disease than carriers of A/A genotype (odds ratio [OR] 2.207, 95% CI: 1.069-4.394, P = 0.028; OR 3.051, 95% CI: 1.086-8.567, P = 0.004; OR 2.964, 95% CI: 1.063-8.265, P = 0.038, respectively). There were no associations between rs10757278 and rs2383207 genotypes and the severity of coronary artery disease (both P > 0.05). Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease. These markers may help the identification of patients at increased risk for early-onset coronary artery disease.
authors.affiliation: Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Qian
authors.forename: Genshan
authors.initials: G
authors.lastname: Ma
authors.forename: Jiahong
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Chengxing
authors.initials: C
authors.lastname: Shen
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Yao
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis