title: A doxycycline hyclate rodent bait formulation for prophylaxis and treatment of tick-transmitted Borrelia burgdorferi.
abstract: The prophylactic and curative potential of doxycycline hyclate formulated in a rodent bait at concentrations of 250 and 500 mg/Kg was evaluated in a murine model of Lyme borreliosis. Both bait formulations prevented tick-transmitted Borrelia burgdorferi infection in 100% of C3H/HeJ mice (N = 16), as well as cured acute, established infection in mice (N = 8) exposed to bait for 14 days. Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. These data provide evidence for exploring alternative techniques to prevent transmission of Lyme disease spirochetes.
authors.affiliation: Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado 80521, USA. mcd4@cdc.gov
authors.forename: Marc C
authors.initials: MC
authors.lastname: Dolan
authors.forename: Nordin S
authors.initials: NS
authors.lastname: Zeidner
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gabitzsch
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Dietrich
authors.forename: Jeff N
authors.initials: JN
authors.lastname: Borchert
authors.forename: Rich M
authors.initials: RM
authors.lastname: Poché
authors.forename: Joseph
authors.initials: J
authors.lastname: Piesman
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D025065:Borrelia burgdorferi / Q000187:drug effects*; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008193:Lyme Disease / Q000188:drug therapy* / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D013987:Ticks / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline