Telmisartan as a metabolic sartan for targeting vascular failure.
BACKGROUND
An angiotensin II type 1 receptor blocker (ARB), telmisartan, has the unique property of activation of PPAR-gamma.


OBJECTIVE
This review aims to discuss clinical perspective of telmisartan for cardiovascular protection.


METHODS
Recent in vitro and in vivo telmisartan data in regard to metabolic regulations were overviewed.


CONCLUSIONS
Telmisartan has direct cardiovascular end-organ protection that goes beyond blood pressure control. In addition, it ameliorates insulin resistance and hypertriglyceridemia, and thereby improves metabolic syndrome. Moreover, it reduces total cholesterol and low-density lipoprotein (LDL)-cholesterol levels, although the mechanisms have not been elucidated. The authors propose to classify this unique ARB as a 'metabolic sartan'. To reduce cardiovascular mortality or morbidity, intense effort should be focused on aggressively modifying risk factors and the early stage of 'vascular failure'. A metabolic sartan may be a powerful tool for targeting 'vascular failure'.
Inoue
Teruo
T
Saga University Faculty of Medicine, Department of Cardiovascular and Renal Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan. inouete@med.saga-u.ac.jp
Node
Koichi
K
D047228:Angiotensin II Type 1 Receptor Blockers / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D005947:Glucose / Q000378:metabolism; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy; D024821:Metabolic Syndrome / Q000188:drug therapy; D047495:PPAR gamma / Q000187:drug effects / Q000378:metabolism; D012307:Risk Factors; D000077333:Telmisartan
D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D047495:PPAR gamma; D002784:Cholesterol; D005947:Glucose; D000077333:Telmisartan