Serum concentrations of adiponectin in patients with hyperthyroidism before and after control of thyroid function.
OBJECTIVE
Thyroid hormone affects adipocyte function, which in turn influences lipid and carbohydrate metabolism. Adiponectin is one of the adipocytokines that regulates lipid and carbohydrate metabolism. The aim of our study was to evaluate circulating levels of adiponectin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate medication.


METHODS
One hundred and twenty patients with hyperthyroidism were recruited at the time of diagnosis. Measurements of free T4 (FT4), thyroid-stimulating hormone (TSH), thyrotropin binding inhibitor immunoglobulin (TBII), adiponectin, fasting blood glucose, fasting serum insulin, lipid profile, and body mass index (BMI) were taken before and after 6 months of medical treatment, at which point all patients were in a euthyroid state.


RESULTS
Any change in BMI was strongly correlated with changes in serum-adiponectin levels (r = -0.789, p<0.001). Any change in serum FT4 was also correlated with changes in BMI and serum adiponectin levels (r = -0.254, p = 0.05 and r = 0.501, p = 0.029 respectively). After controlling for BMI changes, we found correlation also between serum FT4 and adiponectin (r = 0.29, p = 0.005). Multivariate-regression analysis still revealed BMI to be a statistically strong predictor for serum-adiponectin level (p<0.001). However, that analysis also revealed thyroid function level as another predictor (p = 0.029).


CONCLUSIONS
Although BMI is the best predictor of adiponectin, that thyroid hormone might influence circulating levels of adiponectin.
Hsieh
Ching-Jung
CJ
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Wang
Pei-Wen
PW
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
D052242:Adiponectin; D013956:Antithyroid Agents; D013972:Thyrotropin; D013974:Thyroxine