title: Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats.
abstract: In the present study, we have investigated the neuroprotective potential of ginsenoside Re (Re) in the middle cerebral artery occlusion model in Sprague-Dawley rats. Adult male Sprague-Dawley rats were treated with Re (5, 10 or 20 mg kg(- 1), P.O. for 7 days, once a day) prior to occlusion. There was a significant increase in the neurological symptoms in ischemic animals as compared with the sham group animals. These effects were attenuated by 10 and 20 mg kg(- 1) Re, P.O. There was a significant increase in the level of malondialdehyde (MDA) in ischemic animals indicating oxidative stress. An elevated level of MDA in ischemic animals was reduced by 10 and 20 mg kg(- 1) Re, P.O., respectively. It was observed that Re significantly decreased mitochondrial swelling, thereby preventing the reduction of H(+)-ATPase activity. This study demonstrates the neuroprotective potential of Re in cerebral ischemia-reperfusion injury in rats.
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Chen
authors.forename: Xiao-Mian
authors.initials: XM
authors.lastname: Zhou
authors.forename: Ying-Lin
authors.initials: YL
authors.lastname: Cao
authors.forename: Wen-Xiang
authors.initials: WX
authors.lastname: Hu
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D036145:Ginsenosides / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008933:Mitochondrial Swelling / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D018696:Neuroprotective Agents; C049864:ginsenoside Re; D008315:Malondialdehyde; D006180:Proton-Translocating ATPases