Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound.
A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported.
Vilaplana
R
R
Dpto. de Quífmica Inorgánica F. de Química Universidad de Sevilla Sevilla 41071 Spain.
Romero
M A
MA
Quirós
M
M
Salas
J M
JM
González-Vílchez
F
F