Treatment of hypercholesterolemia.
Hypercholesterolemia is an established major risk factor for atherosclerotic disease. While total plasma cholesterol concentration is positively correlated with the incidence of atherosclerosis, this relation is much stronger for LDL-cholesterol. On the other hand, HDL-cholesterol concentration is negatively correlated with atherosclerosis. Thus hypercholesterolemia usually refers to LDL-hypercholesterolemia. In this manuscript the epidemiological evidence and the therapeutic options for the treatment of LDL-hypercholesterolemia are reviewed.
Parhofer
K G
KG
Medical Department II, Klinikum Grossharden, Marchioninstr 15, 81377 Munich, Germany. parhofer@med2.med.uni-muenchen.de