Synthesis of new N-arylpyrimidin-2-amine derivatives using a palladium catalyst.
New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesized from the corresponding amines, applying optimized Buchwald-Hartwig amination conditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxide in refluxing toluene under a nitrogen atmosphere. The target N-aryl derivatives were obtained in moderate to good yields ranging from 27% to 82%. The procedure described could be widely employed for the preparation of new heterocyclic compounds. The structures of the new compounds were confirmed by FT-NMR, FT-IR and elemental analysis.
El-Deeb
Ibrahim Mustafa
IM
Department of Biomolecular Science, University of Science and Technology, Daejon, Korea. dr_i_eldeeb_2003@yahoo.com
Ryu
Jae Chun
JC
Lee
So Ha
SH
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
D000588:Amines; D011743:Pyrimidines; D010165:Palladium