title: Clinical and radiological findings related to tuberous sclerosis complex: a case report.
abstract: OBJECTIVE
  The aim of this report is to present the intraoral and extraoral clinical features of a young female patient with tuberous sclerosis complex (TSC) who exhibited multiple hamartomas of various organ systems including a fibromatous growth on the gingiva.
  
  
  BACKGROUND
  TSC is a rare neurocutaneous syndrome exhibiting multiple hamartomatous proliferations that may involve multiple organs such as the brain, kidney, heart, eyes, lungs and skin. Oral manifestations such as enamel pitting and fibromatous growth of the gingiva are commonly seen in patients with TSC.
  
  
  METHODS
  A 16-year-old female patient presented with a painless interdental gingival growth in the maxillary left incisor and canine region that bled occasionally. Associated findings were adenoma sebaceum (angiofibromas) on the face, a Shagreen patch on the lumbosacral region, ash leaf spots on the trunk, and subangual fibromas (Koenen's tumor) on the nails of fingers and toes. The final diagnosis of TSC was made on the basis of the clinical findings of the skin, computerized tomography (CT) findings of the brain and kidney, ultrasonographic findings of kidney, and a histopathologic evaluation of the gingival growth which met the major and minor criteria required for a diagnosis of TSC.
  
  
  CONCLUSIONS
  This case report is a good example of the complex nature of patients with TSC. The diagnosis and management of these patients varies depending on the specific presentation of the disease. Dentists need to be mindful of the systemic issues as well as oral conditions related to this disease. Dental practitioners are advised to work closely with the patient's physician during treatment.
authors.affiliation: Sharad Pawar Dental College and Hospital of the Datta Meghe Institute of Medical Sciences (Deemed University) in Wardha, India. siddharthgupta99@yahoo.com
authors.forename: Siddharth
authors.initials: S
authors.lastname: Gupta
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhowate
authors.forename: Shirish S
authors.initials: SS
authors.lastname: Degwekar
mesh_terms: D000293:Adolescent; D018322:Angiofibroma / Q000175:diagnosis; D003481:Cuspid / Q000473:pathology; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000175:diagnosis; D005260:Female; D005350:Fibroma / Q000175:diagnosis; D005882:Gingival Diseases / Q000175:diagnosis*; D006222:Hamartoma / Q000175:diagnosis*; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis; D009260:Nail Diseases / Q000175:diagnosis; D012878:Skin Neoplasms / Q000175:diagnosis; D014402:Tuberous Sclerosis / Q000175:diagnosis*