Pulmonary mechanic and lung histology injury induced by Crotalus durissus terrificus snake venom.
In the present work we investigated the effects of Crotalus durissus terrificus venom (CdtV) on the pulmonary mechanic events [static and dynamic elastance, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)] and histology after intramuscular injection of saline solution (control) or venom (0.6 microg/g). The static and dynamic elastance values were increased significantly after 3 h of venom inoculation, but were reduced at control values in the other periods studied. The DeltaP1 values that correspond to the resistive properties of lung tissue presented a significant increase after 6h of CdtV injection, reducing to basal levels 12h after the venom injection. In DeltaP2 analysis, correspondent to viscoelastic components, an increase occurred 12 h after the venom injection, returning to control values at 24 h. CdtV also caused an increase of leukocytes recruitment (3-24 h) to the airways wall as well as to the lung parenchyma. In conclusion, C. durissus terrificus rattlesnake venom leads to lung injury which is reverted, after 24 h of inoculation.
Nonaka
Paula Naomi
PN
Laboratory of Physiology and Pharmacodynamics, Institute of Research and Development-IP&D, University of Vale do Paraiba-UNIVAP, Sao Jose dos Campos, SP, Brazil.
Amorim
César Ferreira
CF
Paneque Peres
Ana Claudia
AC
E Silva
César Augusto Melo
CA
Zamuner
Stella R
SR
Ribeiro
Wellington
W
Cogo
José Carlos
JC
Vieira
Rodolfo P
RP
Dolhnikoff
Marisa
M
de Oliveira
Luis Vicente Franco
LV
D000818:Animals; D003435:Crotalid Venoms / Q000008:administration & dosage / Q000633:toxicity*; D017839:Crotalus; D007273:Injections, Intramuscular; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051379:Mice; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000187:drug effects*; D013990:Tidal Volume / Q000187:drug effects / Q000502:physiology
D003435:Crotalid Venoms