Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population.
OBJECTIVE
To investigate the relationship between the CYP2E1*c1/*c2 polymorphism and alcohol use disorders, and the potential influence of the CYP2E1*c1/*c2 polymorphism on the severity and dimensions of alcohol use disorders in Tibetan.


METHODS
Three hundred and forty Tibetans with Alcohol Use Disorders Identification Test (AUDIT) score >or=10 and another 315 matched control subjects with AUDIT score <or=5 were enrolled. The CYP2E1*c1/*c2 polymorphism was determined by the standard PCR-RFLP method.


RESULTS
The frequency of the CYP2E1*c2 allele in subjects with alcohol use disorders (16.2%) was significantly higher than that of the controls (10.8%), with a P value of 0.005 and OR value of 1.60 (95% CI: 1.15 approximately 2.21). There was also a significant difference in genotype frequencies between the 2 groups (chi2=8.75, P=0.01). Subjects with alcohol use disorders had higher frequencies of genotypes with at least one copy of allele c2 (28.5% vs. 18.7%; chi2=8.65, P=0.003; OR=1.73) than the control group. The association of CYP2E1*c2 allele with alcohol use disorders was much stronger in males than in females, with a male OR value of 2.30. CYP2E1*c2 allele was associated with increased alcohol consumption and alcohol use disorders in males.


CONCLUSIONS
There is the positive association among CYP2E1*c2 allele, alcohol use disorders, and the amount of alcohol consumption in Tibetan population.
Guo
Wan-jun
WJ
Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
Gong-ga-lan-zi
Ou-zhu-luo-bu
Ma
Xiao-hong
XH
Wang
Ying-cheng
YC
Pu
Zhen
Z
Wei
Geng
G
Ji
Yu-lin
YL
Wang
Zheng
Z
Yan
Cheng-yin
CY
Ba-sang-zhu-ma
Shi
Xiao-ming
XM
Liu
Xie-he
XH
Collier
David A
DA
Ball
David
D
Li
Tao
T
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D000483:Alleles; D002681:China / Q000453:epidemiology / Q000208:ethnology; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018609:Tibet / Q000453:epidemiology / Q000208:ethnology
D019392:Cytochrome P-450 CYP2E1