title: Distribution and residue depletion of oxytetracycline in giant freshwater prawn (Macrobrachium rosenbergii).
abstract: Distribution and residue depletion patterns of oxytetracycline were examined in giant freshwater prawns, Macrobrachium rosenbergii, after medicated-feed treatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The concentration of oxytetracycline in prawn muscle tissues was measured using high-performance liquid chromatography equipped with a fluorescence detector. The limit of detection was 0.1 microg/g. In the medicated-feed-treated group, oxytetracycline was detectable 8 days posttreatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The depletion half-life and mean residence time of oxytetracycline were 30.96 and 100.3 h, respectively. The dose of 4 g/kg of feed for 5 consecutive days can be recommended for therapeutic dosage regimen in giant freshwater prawn aquaculture. The minimal withdrawal period of M. rosenbergii muscle tissue should be 8 days postcessation of medicated feed.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900 Thailand. fvetamp@hotmail.com
authors.forename: Amnart
authors.initials: A
authors.lastname: Poapolathep
authors.forename: Saranya
authors.initials: S
authors.lastname: Poapolathep
authors.forename: Kanjana
authors.initials: K
authors.lastname: Imsilp
authors.forename: Nutthapong
authors.initials: N
authors.lastname: Wannapat
authors.forename: Narumol
authors.initials: N
authors.lastname: Klangkaew
authors.forename: Napasorn
authors.initials: N
authors.lastname: Kusutjarit
authors.forename: Susumu
authors.initials: S
authors.lastname: Kumagai
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003257:Consumer Product Safety; D004350:Drug Residues / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D009132:Muscles / Q000737:chemistry; D010118:Oxytetracycline / Q000032:analysis*; D033541:Palaemonidae / Q000737:chemistry*; D012758:Shellfish / Q000032:analysis* / Q000592:standards; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D010118:Oxytetracycline