title: Defunctioning stomas in patients with locally advanced rectal cancer prior to preoperative chemoradiotherapy.
abstract: OBJECTIVE
  A literature search did not produce any evidence-based objective criteria to determine which patients with locally advanced rectal cancer would benefit from a defunctioning stoma prior to neoadjuvant chemoradiotherapy. Our criteria for formation of a defunctioning stoma are: faecal incontinence and inability to cannulate the tumour at colonoscopy. The aim of this study was to examine whether these current criteria are appropriate.
  
  
  METHODS
  Forty-nine consecutive locally advanced rectal cancer patients treated from February 2003 to November 2006 were identified from our colorectal database. All received long-course chemoradiotherapy (Bossett regimen) and definitive surgery was performed 6-8 weeks later.
  
  
  RESULTS
  Of the 49 patients, 31 presented with diarrhoea and two with faecal incontinence; nine patients were defunctioned by trephine stoma prior to treatment [cannulation impossible at colonoscopy (n = 8); faecal incontinence (n = 1)]. One patient with faecal incontinence refused early defunctioning stoma. Median hospital stay was 12 days (interquartile range: 7-30), and complications included pneumonia (n = 1) and peristomal cellulitis (n = 2). Of the 40 patients who went directly to neoadjuvant chemoradiotherapy, two subsequently required a defunctioning stoma for severe diarrhoeal symptoms during therapy. Eight patients had worsening diarrhoeal symptoms but tolerated treatment. Three patients, who had stoma formation, did not proceed to definitive surgery following neoadjuvant therapy: poor operative fitness (n = 2) and disease progression (n = 1).
  
  
  CONCLUSIONS
  Stenosis causing inability to cannulate the tumour at colonoscopy and faecal incontinence were the only objective indications for an early defunctioning stoma. Worsening diarrhoea during therapy (unless severe) did not appear to be a good indication for a defunctioning stoma.
authors.affiliation: Department of Surgery, Southern General Hospital, Glasgow, UK. craigparnaby@aol.com
authors.forename: C N
authors.initials: CN
authors.lastname: Parnaby
authors.forename: J T
authors.initials: JT
authors.lastname: Jenkins
authors.forename: V
authors.initials: V
authors.lastname: Weston
authors.forename: D M
authors.initials: DM
authors.lastname: Wright
authors.forename: G T
authors.initials: GT
authors.lastname: Sunderland
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D054047:Surgical Stomas