Recurrent cerebral venous thrombosis revealing paraneoplastic angiitis in Hodgkin's lymphoma.
Recurrent cerebral venous thrombosis (CVT), as a manifestation of paraneoplastic angiitis and revealing of nodular lymphocyte predominant Hodgkin's disease (NLPHD), is an extremely rare condition. We herein report a 55-year-old man who developed recurrent CVT despite efficacious anticoagulant therapy and subsequent stenting of the superior longitudinal sinus. Progressive neurological deterioration ensued and a body scan revealed axillary lymph nodes. Pathological analysis led to a diagnosis of NLPHD. Conventional angiography showed CVT and multiple arterial narrowings. A paraneoplastic primary cerebral angiitis with prominent venous structure involvement was suspected. Immunotherapy using rituximab and steroids provided a dramatic recovery. This case of CVT due to paraneoplastic cerebral angiitis is a rare condition and represents a new, very rare manifestation of nodular lymphocyte predominant Hodgkin's disease.
Roggerone
Stephanie
S
Cerebrovascular Unit, Hôpital Neurologique Pierre Wertheimer, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Traverse-Glehen
Alexandra
A
Derex
Laurent
L
Honnorat
Jerome
J
Berger
Francoise
F
Salles
Gilles
G
Rousset
Hugues
H
Trouillas
Paul
P
Nighoghossian
Norbert
N
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20 / Q000378:metabolism; D002533:Cerebral Angiography / Q000379:methods; D002550:Cerebral Veins / Q000473:pathology*; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000150:complications* / Q000473:pathology; D000069283:Rituximab; D020293:Vasculitis, Central Nervous System / Q000209:etiology* / Q000473:pathology; D020246:Venous Thrombosis / Q000209:etiology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D000069283:Rituximab