Prenatal exposure to maternal infections and epilepsy in childhood: a population-based cohort study.
OBJECTIVE
We estimated the association between prenatal exposure to maternal infections and the subsequent risk for epilepsy in childhood.


METHODS
We included 90,619 singletons who were born between September 1997 and June 2003 in the Danish National Birth Cohort and followed them up to December 2005. Information on maternal infections during pregnancy (cystitis, pyelonephritis, diarrhea, coughs lasting >1 week, vaginal yeast infection, genital herpes, venereal warts, and herpes labialis) was prospectively reported by mothers in 2 computer-assisted telephone interviews in early and midgestation; information on maternal cystitis and pyelonephritis during late period of pregnancy was also collected in a third interview after birth. Children who received a diagnosis of epilepsy as inpatients or outpatients were retrieved from the Danish National Hospital Register. We identified 646 children with a diagnosis of epilepsy during up to 8 years of follow-up time. Cox proportional hazards regression models were used to estimate incidence rate ratio and 95% confidence interval.


RESULTS
Children who were exposed to maternal cystitis, pyelonephritis, diarrhea, coughs, and/or vaginal yeast infection some maternal infections in prenatal life had an increased risk for epilepsy. Coughs lasting >1 week were associated with an increased risk for epilepsy only in the first year of life, as was vaginal yeast infection only in children who were born preterm. These associations remained unchanged for children without cerebral palsy, congenital malformation, or a low Apgar score at 5 minutes.


CONCLUSIONS
Prenatal exposure to some maternal infections was associated with an increased risk for epilepsy in childhood.
Sun
Yuelian
Y
Department of Epidemiology, University of Aarhus, Vennelyst Boulevard 6, Aarhus, 8000 C, Denmark. ys@soci.au.dk
Vestergaard
Mogens
M
Christensen
Jakob
J
Nahmias
André J
AJ
Olsen
Jørn
J
D002181:Candidiasis, Vulvovaginal / Q000150:complications; D002675:Child, Preschool; D003371:Cough; D003556:Cystitis / Q000150:complications; D003967:Diarrhea / Q000150:complications; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011704:Pyelonephritis / Q000150:complications; D012307:Risk Factors