Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.
Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.
Hayashi
Yoshio
Y
Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan. yhayashi@ps.toyaku.ac.jp
Regnier
Thomas
T
Nishiguchi
Shigenobu
S
Sydnes
Magne O
MO
Hashimoto
Daisuke
D
Hasegawa
Junya
J
Katoh
Takahiro
T
Kajimoto
Tetsuya
T
Shiozuka
Masataka
M
Matsuda
Ryoichi
R
Node
Manabu
M
Kiso
Yoshiaki
Y
D000599:Amino Acids, Diamino / Q000138:chemical synthesis; D005563:Formic Acid Esters / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
D000599:Amino Acids, Diamino; D005563:Formic Acid Esters; C000345:t-butyloxycarbonyl group; C015662:2-aminoacetaldehyde; C100200:negamycin; D005998:Glycine