title: Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations.
abstract: Kikuchi's disease, also known as histiocytic necrotizing lymphadenitis, is a systemic illness with classic clinical findings of cervical lymphadenopathy and fever. Diagnosis is confirmed by lymph node histology, which reveals paracortical foci of necrosis and a histiocytic infiltrate. Kikuchi's disease has been associated with a number of infections, but no single source has been identified. Diverse, often nonspecific, cutaneous findings have been described in up to 40% of cases. Description of the histopathologic findings of skin lesions is limited to single case reports and one case series. We describe a 24-year-old woman with fevers, lymphadenopathy, hepatic and hematologic abnormalities, and a skin eruption involving the face, neck, trunk, and extremities with characteristic lymph node and cutaneous histopathologic findings. We completed a systematic review of the clinical presentations and histopathology of Kikuchi's disease.
authors.affiliation: Department of Dermatology, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin 53715, USA.
authors.forename: Amber Reck
authors.initials: AR
authors.lastname: Atwater
authors.forename: B Jack
authors.initials: BJ
authors.lastname: Longley
authors.forename: William D
authors.initials: WD
authors.lastname: Aughenbaugh
mesh_terms: D000328:Adult; D001365:Axilla; D001706:Biopsy; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D012867:Skin / Q000473:pathology