title: Temporal correlation between malaria and rainfall in Sri Lanka.
abstract: BACKGROUND
  Rainfall data have potential use for malaria prediction. However, the relationship between rainfall and the number of malaria cases is indirect and complex.
  
  
  METHODS
  The statistical relationships between monthly malaria case count data series and monthly mean rainfall series (extracted from interpolated station data) over the period 1972 - 2005 in districts in Sri Lanka was explored in four analyses: cross-correlation; cross-correlation with pre-whitening; inter-annual; and seasonal inter-annual regression.
  
  
  RESULTS
  For most districts, strong positive correlations were found for malaria time series lagging zero to three months behind rainfall, and negative correlations were found for malaria time series lagging four to nine months behind rainfall. However, analysis with pre-whitening showed that most of these correlations were spurious. Only for a few districts, weak positive (at lags zero and one) or weak negative (at lags two to six) correlations were found in pre-whitened series. Inter-annual analysis showed strong negative correlations between malaria and rainfall for a group of districts in the centre-west of the country. Seasonal inter-annual analysis showed that the effect of rainfall on malaria varied according to the season and geography.
  
  
  CONCLUSIONS
  Seasonally varying effects of rainfall on malaria case counts may explain weak overall cross-correlations found in pre-whitened series, and should be taken into account in malaria predictive models making use of rainfall as a covariate.
authors.affiliation: International Water Management Institute, PO Box 2075, Colombo, Sri Lanka. o.briet@cgiar.org
authors.forename: Olivier J T
authors.initials: OJ
authors.lastname: Briët
authors.forename: Penelope
authors.initials: P
authors.lastname: Vounatsou
authors.forename: Dissanayake M
authors.initials: DM
authors.lastname: Gunawardena
authors.forename: Gawrie N L
authors.initials: GN
authors.lastname: Galappaththy
authors.forename: Priyanie H
authors.initials: PH
authors.lastname: Amerasinghe
mesh_terms: D005843:Geography; D006801:Humans; D008288:Malaria / Q000453:epidemiology*; D011891:Rain; D012621:Seasons; D013188:Sri Lanka / Q000453:epidemiology; D013223:Statistics as Topic