Association of the ins/del polymorphisms of uncoupling protein 2 (UCP2) with BMI in a Korean population.
To elucidate the potential impact of the variants of the UCP2 gene on obesity phenotypes, we have genotyped four polymorphisms in UCP2 among 988 Korean subjects using TaqMan methods, and three common haplotypes with frequency greater than 0.1 were constructed in the Korean population. No significant associations were detected with the risk of metabolic syndrome by logistic regression analyses. However, the 45 base-pair ins/del polymorphism (+3474 ins/del) in the 3' untranslated region (3' UTR) showed significant association with body mass index (P=0.007, P(corr)=0.02) and waist circumference (P=0.005). Further subgroup analysis revealed that the genetic effects were more apparent among female subjects. In addition, a summary of the controversial genetic effects on obesity mediated by UCP2 polymorphisms from previous studies is also given. Our results suggest that subjects with a 45bp insertion allele of UCP2+3474 ins/del might have a higher risk of developing obesity, although the biological effects of this variant are not completely known.
Lee
Yong Hwan
YH
Department of Preventive Medicine and Institute of Natural Products for Health Promotion, Kosin Medical College, Busan 602-703, Republic of Korea.
Kim
Won
W
Yu
Byeng Chul
BC
Park
Byung Lae
BL
Kim
Lyoung Hyo
LH
Shin
Hyoung Doo
HD
D020413:3' Untranslated Regions / Q000235:genetics; D000483:Alleles; D015992:Body Mass Index; D005260:Female; D006801:Humans; D054643:INDEL Mutation; D007473:Ion Channels / Q000235:genetics*; D007723:Korea; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D017720:Molecular Epidemiology; D009765:Obesity / Q000235:genetics*; D020161:Physical Chromosome Mapping; D011110:Polymorphism, Genetic; D000071246:Uncoupling Protein 2
D020413:3' Untranslated Regions; D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2