Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response.
In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both ex vivo induced antigen-specific proliferation as well as production of proinflammatory cytokines by splenocytes were higher in IL-10 KO mice than in WT mice. Also, intrapulmonary proinflammatory cytokine levels were higher in IL-10 KO mice than in the WT mice. The lack of anti-inflammatory action of IL-10 is likely to contribute to the enhanced clearance but severe inflammation in this experimental model.
Penttilä
Tuula
T
Department of Virology, Haartman Institute, University of Helsinki, Finland.
Haveri
Anu
A
Tammiruusu
Anne
A
Vuola
Jenni M
JM
Lahesmaa
Riitta
R
Puolakkainen
Mirja
M
D000818:Animals; D049109:Cell Proliferation; D002690:Chlamydia Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D016993:Chlamydophila pneumoniae / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D016207:Cytokines; D016753:Interleukin-10