A comparative neutron activation analysis study of common generic manipulated and reference medicines commercialized in Brazil.
In this work, a comparative study of neutron activation analysis (NAA) was performed by the nuclear institutes: CDTN/CNEN-Brazil, CCHEN-Chile and the SCK.CEN-Belgium aiming to investigate some generic, manipulated and reference medicines largely commercialized in Brazil. Some impurities such as: As, Ba, Br, Ce, Co, Cr, Eu, Fe, Hf, Sb, Sc, Sm, Ti and Zn were found, and the heterogeneity of the samples pointed out the lack of an efficient public system of quality control.
Leal
A S
AS
Nuclear Technology Development Centre/Brazilian Commission for Nuclear Energy (CDTN/CNEN), Caixa Postal 941, CEP 30161-970, Belo Horizonte, Minas Gerais, Brazil. asleal@cdtn.br
Menezes
M A B C
MA
Rodrigues
R R
RR
Andonie
O
O
Vermaercke
P
P
Sneyers
L
L
D001938:Brazil; D004341:Drug Evaluation / Q000379:methods* / Q000592:standards*; D016568:Drugs, Generic / Q000032:analysis* / Q000592:standards*; D009501:Neutron Activation Analysis / Q000379:methods* / Q000592:standards*; D012016:Reference Values
D016568:Drugs, Generic