Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy.
OBJECTIVE
To investigate the association between the expressions of leukemia inhibitory factor and the occurrence of tubal pregnancy.


METHODS
Prospective observational study.


METHODS
University-based obstetrics and gynecology hospital.


METHODS
Thirty women undergoing salpingectomy for tubal pregnancy and 30 nonpregnant patients with benign uterine or appendix disease.


METHODS
Oviduct tissues with ectopic gestation were separated into implantation sites and nonimplantation sites. Samples of ampullary fallopian tubes during midsecretory phase were collected as control groups. Immunohistochemical and Western blot analysis were performed.


METHODS
The differences of leukemia inhibitory factor expression between the implantation and nonimplantation sites of oviduct tissues and the normal and chronically inflamed fallopian tubes.


RESULTS
The expression of leukemia inhibitory factor in the implantation group is significantly higher than that in the nonimplantation group or in the normal group. A statistically significant difference was also found for leukemia inhibitory factor between the chronic inflammation group and the normal group by Western blot analysis but no difference between the chronic inflammation group and the implantation group or the nonimplantation group.


CONCLUSIONS
Leukemia inhibitory factor might be one of the reasons that cause patients with salpingitis to be more susceptible to tubal pregnancy and might be involved in the implantation process of tubal pregnancy.
Ji
Yin Fen
YF
Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Chen
Li You
LY
Xu
Kai Hong
KH
Yao
Ji Fen
JF
Shi
Yi Fu
YF
D000328:Adult; D010064:Embryo Implantation; D005187:Fallopian Tubes / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism; D053605:Leukemia Inhibitory Factor / Q000378:metabolism*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D011274:Pregnancy, Tubal / Q000378:metabolism / Q000601:surgery*; D012488:Salpingitis / Q000378:metabolism / Q000601:surgery; D055815:Young Adult
C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor