title: Congenital Chagas disease: diagnostic and clinical aspects in an area without vectorial transmission, Bermejo, Bolivia.
abstract: The authors carried out a 1-year study of a population of pregnant women delivering at Bermejo hospital, South Bolivia. In this area, vectorial transmission of Trypanosoma cruzi is negligible and women infect themselves during displacements in close endemic areas. The prevalence of T. cruzi in 508 pregnant women, diagnosed by several serological tests, was 33.9%. In eight infants, we observed T. cruzi in the umbilical cord (congenital transmission rate of 5.2%). The means of birth weights, lengths and hemoglobin rates were similar in the children from both seronegative and seropositive women, and in children infected or not by T. cruzi. This study could confirm a less severity of the congenital disease of Chagas in the absence of re-infestation of the mother during pregnancy. Serological screening of pregnant women by rapid diagnostic tests and examination of babies born from seropositive mothers by microhematocrit method at birth is a suitable strategy to detect and prevent congenital Chagas disease in non-endemic areas.
authors.affiliation: IRD UR010, Research Unit Mother's and Child's Health in Tropical Environment, Institut de Recherche pour le Développement, La Paz, Bolivia.
authors.forename: L
authors.initials: L
authors.lastname: Brutus
authors.forename: D
authors.initials: D
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Postigo
authors.forename: M
authors.initials: M
authors.lastname: Romero
authors.forename: J
authors.initials: J
authors.lastname: Santalla
authors.forename: J P
authors.initials: JP
authors.lastname: Chippaux
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001838:Bolivia / Q000453:epidemiology; D014355:Chagas Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology* / Q000635:transmission; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000469:parasitology*; D011247:Pregnancy; D015995:Prevalence; D012698:Serologic Tests; D014349:Trypanosoma cruzi / Q000302:isolation & purification*; D014470:Umbilical Cord / Q000469:parasitology