Improved procedure for the synthesis of enamine N-oxides.
An improved procedure for the preparation of enamine N-oxides involving aminolysis of epoxides, chlorination, N-oxidation, and dehydrochlorination is described. Although isolated beta-chloroamine N-oxides are prone to rearrangements when isolated, these side reactions can be slowed by the presence of stabilizing organic acids. The scope and limitations of this strategy are discussed.
Bernier
David
D
School of Chemistry, The University of Nottingham, Nottingham, United Kingdom.
Blake
Alexander J
AJ
Woodward
Simon
S