title: Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells.
abstract: This study reports that TNF-alpha is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1alpha, IL-1beta, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-alpha on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.
authors.affiliation: Laboratoire d'Hématologie Expérimentale Faculté de Médecine 2 rue Dr. Marcland Limoges 87025 France.
authors.forename: F
authors.initials: F
authors.lastname: Rougier
authors.forename: E
authors.initials: E
authors.lastname: Cornu
authors.forename: N
authors.initials: N
authors.lastname: Gachard
authors.forename: V
authors.initials: V
authors.lastname: Praloran
authors.forename: Y
authors.initials: Y
authors.lastname: Denizot