title: Effects of oral administration of Stephania tetrandra S. Moore on neovascularization of retinal and choroidal capillaries of diabetes in rats.
abstract: In rats, an injection of streptozotocin (STZ) elevated blood levels of glucose 4 weeks later (STZ-induced diabetes) and an over-production of microvessels of retinal and choroidal capillaries of eyes developed. A previous study has shown that administration of Stephania tetrandra S. Moore (STSM) in culture prevented the over-production of microvessels of those capillaries of STZ-induced diabetes in vitro. Therefore, the study investigated whether or not orally administered STSM could inhibit over-production of microvessels of those capillaries of STZ injected rats in vivo. When STSM was given at the same time as the STZ injection and continued daily for 7 weeks, STSM prevented the elevation of blood glucose level and over-production of microvessels of those capillaries. When STSM was given after elevation of blood glucose level of glucose (4 weeks after STZ injection) and continued daily for 4 weeks, STSM lowered the elevated blood glucose level but had no effect on the over-production of microvessels of those capillaries. It was inferred that deposition of N(epsilon)(carboxymethyl) lysine in retinal and choroidal tissues, which is induced by STZ-induced diabetes may deteriorate the blood-retinal barrier and the blood-choroidal barrier. One might, therefore, speculate that advanced STZ-induced diabetes may deteriorate the blood-retinal barrier and blood-choroidal barrier. Therefore, STSM may not reach the retinal and choroidal tissues in the posterior ocular region in vivo.
authors.affiliation: Tulane University Hebert Research Center, and Department of Medicine, Tulane University Health Sciences Center, School of Medicine, 3705 Main Street, Belle Chasse, LA 70037, USA.
authors.forename: Taiki
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Hagino
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Liang
authors.forename: Sai-Shan
authors.initials: SS
authors.lastname: Guo
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002196:Capillaries / Q000187:drug effects / Q000503:physiopathology; D020256:Choroidal Neovascularization / Q000503:physiopathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015861:Retinal Neovascularization / Q000503:physiopathology / Q000517:prevention & control*; D031609:Stephania tetrandra / Q000737:chemistry*; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D013311:Streptozocin