Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes.
OBJECTIVE
To examine functional brain activation patterns before and after postconcussive symptoms (PCS) resolution.


METHODS
Prospective serial study with male athletes using functional magnetic resonance imaging (fMRI).


METHODS
Hospital laboratory and imaging facility.


METHODS
9 symptomatic concussed athletes who experienced persisting PCS at least 1 month postinjury and 6 healthy athletes.


METHODS
All athletes filled out a PCS checklist and underwent an fMRI session during which they performed a working-memory task.


METHODS
Behavioral outcomes were response speed and accuracy on the working memory tasks performed during the fMRI session. Functional imaging outcomes were blood oxygen level-dependent fMRI activation patterns associated with a working memory task.


RESULTS
: There was no difference in behavioral performance between the groups. Despite normal structural MRI findings, all symptomatic concussed athletes initially showed atypical brain activation patterns in the dorsolateral prefrontal cortex (DLPC). Compared to the initial postinjury evaluation, those athletes at follow-up with PCS resolved showed significant increases in activation in the left DLPC. Concussed athletes whose PCS status remained unchanged at follow-up continued to show atypical activation in DLPC. Healthy athletes showed remarkably clear and consistent brain activations in DLPC initially as well as in follow-up, highlighting the test-retest reliability of fMRI.


CONCLUSIONS
The results demonstrate the feasibility of using fMRI to detect an underlying pathology in symptomatic concussed athletes with normal structural imaging results and its potential to document recovery. Such information may be of considerable value for clinical judgment and patient management.
Chen
Jen-Kai
JK
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Johnston
Karen M
KM
Petrides
Michael
M
Ptito
Alain
A
D000328:Adult; D001265:Athletic Injuries; D006259:Craniocerebral Trauma / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation*; D019317:Evidence-Based Medicine; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D020127:Recovery of Function; D015599:Trauma Severity Indices