title: Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative.
abstract: This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three conferences that will systematically address barriers to translating paradigms developed in the basic animal and human cognitive neuroscience fields for use in translational research aimed at developing novel treatments for cognitive impairments in schizophrenia. The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts.
authors.affiliation: Department of Psychiatry, University of California, Davis, CA 95817, USA. cameron.carter@ucdmc.ucdavis.edu
authors.forename: Cameron S
authors.initials: CS
authors.lastname: Carter
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Barch
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
authors.forename: Ed
authors.initials: E
authors.lastname: Bullmore
authors.forename: John H
authors.initials: JH
authors.lastname: Krystal
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cohen
authors.forename: Mark
authors.initials: M
authors.lastname: Geyer
authors.forename: Michael
authors.initials: M
authors.lastname: Green
authors.forename: Keith H
authors.initials: KH
authors.lastname: Nuechterlein
authors.forename: Trevor
authors.initials: T
authors.lastname: Robbins
authors.forename: Steven
authors.initials: S
authors.lastname: Silverstein
authors.forename: Edward E
authors.initials: EE
authors.lastname: Smith
authors.forename: Milton
authors.initials: M
authors.lastname: Strauss
authors.forename: Til
authors.initials: T
authors.lastname: Wykes
authors.forename: Robert
authors.initials: R
authors.lastname: Heinssen
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D035843:Biomedical Research; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D003299:Cooperative Behavior; D004345:Drug Industry; D006801:Humans; D009315:National Institute of Mental Health (U.S.); D009483:Neuropsychological Tests; D012109:Research Support as Topic; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D014150:Antipsychotic Agents