title: Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barré syndrome.
abstract: Guillain-Barré syndrome (GBS) is an inflammatory disease of the peripheral nervous system which can cause pain via mechanisms that are poorly understood. Here, we show that in rat experimental autoimmune neuritis (EAN) mechanical allodynia developed up to 9 days before the onset of detectable neurological deficits. Allodynia was associated with an increase in the number of microglial cells in the dorsal horn of the spinal cord. The expression of the chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 were also higher in EAN than in control dorsal horns suggesting spinal microglia and CX3CL1/CX3CR1 may play a role in the pain-like behaviour.
authors.affiliation: Neurorestoration group, Wolfson Centre for Age Related Diseases, King's College London, London, UK.
authors.forename: Livio
authors.initials: L
authors.lastname: Luongo
authors.forename: Marija
authors.initials: M
authors.lastname: Sajic
authors.forename: John
authors.initials: J
authors.lastname: Grist
authors.forename: Anna K
authors.initials: AK
authors.lastname: Clark
authors.forename: Sabatino
authors.initials: S
authors.lastname: Maione
authors.forename: Marzia
authors.initials: M
authors.lastname: Malcangio
mesh_terms: D000818:Animals; D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1 / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D020275:Guillain-Barre Syndrome / Q000378:metabolism / Q000473:pathology*; D017628:Microglia / Q000473:pathology*; D009444:Neuritis, Autoimmune, Experimental / Q000378:metabolism / Q000473:pathology*; D017288:Pain Threshold / Q000502:physiology*; D020671:Posterior Horn Cells / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011917:Rats, Inbred Lew; D019707:Receptors, Chemokine / Q000378:metabolism
chemical_list: D000073883:CX3C Chemokine Receptor 1; C516305:CX3CR1 protein, rat; D054428:Chemokine CX3CL1; C515540:Cx3cl1 protein, rat; D019707:Receptors, Chemokine