title: [Role of cytokines in the modulation of lymphocytic subpopulational composition in patients with pulmonary tuberculosis].
abstract: The parameters of the lymphocytic CD-population composition and the production of cytokines in the cell cultures of peripheral blood mononuclear cells were studied in patients with infiltrative pulmonary tuberculosis. A marked reduction in the relative and absolute count of CD3+ and CD4+ lymphocytes and an increase in the level of CD8- and CD16-positive cells were established in both drug-sensitive and drug-resistant types of the disease. A significant increase in the production of IL-12 and a reduction in the spontaneous elaboration of interferon-gamma were observed in all the examinees. Addition of lipid and protein myobacterial antigens (Beijing strains) caused a notable decrease in the generation of the study cytokines as compared with the respective parameters in healthy donors and their basal secretion irrespective of the type of a tuberculous process.
authors.forename: R R
authors.initials: RR
authors.lastname: Khasanova
authors.forename: O V
authors.initials: OV
authors.lastname: Voronkova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: A K
authors.initials: AK
authors.lastname: Strelis
authors.forename: A E
authors.initials: AE
authors.lastname: Kolosova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Stambula
authors.forename: V A
authors.initials: VA
authors.lastname: Serebriakova
authors.forename: I O
authors.initials: IO
authors.lastname: Naslednikova
authors.forename: O V
authors.initials: OV
authors.lastname: Kolokova
authors.forename: O A
authors.initials: OA
authors.lastname: Vasil'eva
authors.forename: T E
authors.initials: TE
authors.lastname: Budkina
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism*
chemical_list: D016207:Cytokines