title: [Bone quality changes in diabetes].
abstract: Diabetes-related bone fragility has recently drawn many researchers' attention. Diabetes would affect bone remodeling by various mechanisms, including deficiency of insulin actions, increased accumulation of advanced glycation end products and microangiopathy. The combination of poor bone quality of microstructure and nanoarchitecture (type I collagen and non-collageous proteins) would reduce bone strength. Bone mineral density is the best predictor for fractures of primary osteoporosis, but presumably not for type 2 diabetes. Quality changes of diabetic bone, therefore, should be more thoroughly studied.
authors.affiliation: Josai International University, Faculty of Pharmaceutical Sciences, Department of Clinical Science.
authors.forename: Seiki
authors.initials: S
authors.lastname: Wada
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Kamiya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukawa
mesh_terms: D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000172:deficiency
chemical_list: D024042:Collagen Type I; D017127:Glycation End Products, Advanced; D007328:Insulin