A novel steroidal glycoside, ophiofurospiside A from Ophiopogon japonicus (Thunb.) Ker-Gawl.
A new furospirostanol saponin, ophiofurospiside A (1), was isolated together with the known steroidal glycosides 2, 3, and 4 from the tubers of Ophiopogon japonicus (Thunb.) Ker-Gawl. Using chemical and spectral analyses (IR, MS, 1D NMR, and 2D NMR), the structure of 1 was established as 26-O-beta-d-glucopyranosyl-(22S, 25R)-furospirost-5-ene-3beta, 17alpha, 26-triol-3-O-[alpha-l-rhamnopyranosyl-(1 --> 2)]-[beta-d-xylopyranosyl-(1 --> 4)]-glucopyranoside (1). Three known steroidal saponins 2-4 were identified on the basis of spectroscopic data.
Xu
Tun-Hai
TH
Department of Traditional Chinese Medicine Chemistry, Beijing University of Chinese Medicine, Beijing, China.
Xu
Ya-Juan
YJ
Xie
Sheng-Xu
SX
Zhao
Hong-Feng
HF
Han
Dong
D
Li
Yu
Y
Niu
Jian-Zhao
JZ
Xu
Dong-Ming
DM
D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006027:Glycosides / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D031441:Ophiopogon / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization; D013256:Steroids / Q000302:isolation & purification
C531134:26-O-glucopyranosylfurospirost-5-ene-3,17,26-triol-3-O-(rhamnopyranosyl-1-2)(xylopyranosyl-1-4)glucopyranoside; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012503:Saponins; D013256:Steroids