A carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation in vitro.
The antioxidative effect of the carotenoids phytoene and phytofluene in biological systems has not yet been studied. We therefore sought to investigate the effect of these carotenoids, isolated from the alga Dunaliella bardawil, in a biological system and used the in vitro low density lipoprotein (LDL) oxidation method to assay their antioxidative effects. We found that similar to beta-carotene and alpha-tocopherol, a carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation. These findings and the presence of phytoene and phytofluene in human tissues suggest that they can be part of the defense system against oxidative stress.
Shaish
Aviv
A
The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel. aviv.shaish@sheba.health.gov.il
Harari
Ayelet
A
Kamari
Yehuda
Y
Soudant
Etienne
E
Harats
Dror
D
Ben-Amotz
Ami
A
D002338:Carotenoids / Q000494:pharmacology*; D056890:Eukaryota / Q000737:chemistry*; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D008077:Lipoproteins, LDL; D002338:Carotenoids; C003140:phytofluene; C100185:(all-E) phytoene