Structure revision of circumdatins A and B, benzodiazepine alkaloids produced by marine fungus Aspergillus ostianus, by X-ray crystallography.
The structures of circumdatins A and B, pentacyclic alkaloids produced by Aspergillus ostianus, were revised from the previously reported betaine structures to unique oxepin ones by X-ray crystallography. The co-occurring known alkaloids, circumdatins D, E, and H, and a new compound reported here, circumdatin J, have a common framework.
Ookura
Ryuhei
R
Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8505, Japan and Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan
Kito
Keijiro
K
Ooi
Takashi
T
Namikoshi
Michio
M
Kusumi
Takenori
T
D001230:Aspergillus / Q000378:metabolism*; D001570:Benzodiazepinones / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D013058:Mass Spectrometry; D008958:Models, Molecular; D015394:Molecular Structure
D001570:Benzodiazepinones; C530782:circumdatin A; C530783:circumdatin B