title: Association of angiotensin-converting enzyme gene 2350G>A polymorphism with myocardial infarction in a Chinese population.
abstract: Angiotensin-converting enzyme (ACE) gene 2350G>A polymorphism has the most significant effect on plasma ACE concentrations. But the association between this polymorphism and myocardial infarction (MI) is presently unknown. We carried out a case-control study in the Chinese Han population. ACE2350G>A genotypes of 231 patients with MI and 288 healthy controls were detected by PCR-RFLP. Differences in frequencies of ACE genotypes and alleles and their associations with clinical features were assessed. The distribution of the ACE2350G>A genotypes (GG, GA, and AA) was 20.78%, 51.08%, and 28.14% in the MI group and 31.60%, 46.53%, and 21.87% in controls, respectively (P = .0167).The frequency of the A allele in the MI group was significantly higher than that in controls (53.68% vs 45.14%, P = .0062). The A allele carriers (GA + AA genotypes) had approximately 2-fold increased risk of MI when compared with the GG genotype (odds ratio = 1.76; 95% confidence interval = 1.24-3.52). There were no significant differences among the 3 genotypes in plasma levels of lipids, apolipoproteins, high-sensitivity C-reactive protein, and soluble CD40 ligand in either the MI group or the control group (P > .05). No statistical difference was observed between ACE2350G>A polymorphism and severity of the coronary lesions (P > .05). These results suggest that ACE2350G>A polymorphism is associated with acute MI, and A allele carrier is an independent risk factor for acute MI in the Chinese Han population.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Soochow University, 20 Xisi Road, Suzhou, China.
authors.lastname: Min Pan
authors.forename: Min-Hui
authors.initials: MH
authors.lastname: Jiang
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Wei
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Jiang
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Geng
authors.forename: Zhi-Chu
authors.initials: ZC
authors.lastname: Cui
authors.forename: Dong-Lei
authors.initials: DL
authors.lastname: Zhang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A