Anti-tumor activity, in vitro and in vivo, of some triphenylphosphinegold(i) thionucleobases.
The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph(3)PAu(6-MP)] and [Ph(3)PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph(3)PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.
Webster
L K
LK
Experimental Chemotherapy and Pharmacology Laboratory Peter MacCallum Cancer Institute East Melbourne Victoria 3002 Australia.
Rainone
S
S
Horn
E
E
Tiekink
E R
ER