Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy.
The behavioral effects induced by methamphetamine (5.0 mg/kg) were compared in the mutant mice lacking d-amino acid oxidase activity and normal mice. The mutant mice exhibited marked decline in the methamphetamine-induced stereotypy compared to the normal mice, whereas the mutant mice displayed a drastic augmentation in the locomotor activity evoked by methamphetamine compared to the normal mice. Because the d-serine levels in the brain of the mutant mice are significantly higher than those in the normal mice, the enhanced d-serine in the brain of the mutant mice could antagonize the methamphetamine-induced stereotypy via the N-methyl-d-aspartate receptors.
Hashimoto
Atsushi
A
Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259-1143, Japan. hashimot@is.icc.u-tokai.ac.jp
Konno
Ryuichi
R
Yano
Hiroshi
H
Yoshikawa
Masanobu
M
Tamaki
Raita
R
Matsumoto
Hideo
H
Kobayashi
Hiroyuki
H
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003605:D-Amino-Acid Oxidase / Q000172:deficiency* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D018345:Mice, Knockout; D013239:Stereotyped Behavior / Q000187:drug effects*
D000697:Central Nervous System Stimulants; D006213:Hallucinogens; D008694:Methamphetamine; D003605:D-Amino-Acid Oxidase