title: Use of exposure time and life expectancy in models for toxicity to aquatic organisms.
abstract: The exposure time is a variable which is usually not incorporated into models for toxicity. However, with persistent organic pollutants (POPs) exhibiting a nonspecific mode of action and lipophilic properties this variable can be modeled by the usage of the internal concentrations as a measure of the toxicity with fish. The bioconcentration process with fish is a relatively well understood and predictable process which allows the calculation of the internal lethal concentration. When the exposure time is relatively short the critical internal lethal concentrations are relatively constant for the group of POPs whereaas the LC50 measured in the ambient water is quite variable. When the exposure time is relatively long, results on the measurement of the critical internal concentration with fish over different exposure times has demonstrated that the internal lethal concentration falls with increasing exposure times in a consistent and predictable manner. This reduction in life expectancy can be described in a model which can be used to estimate the critical internal concentration for any exposure time. It also provides information useful in assessing the risk to fish and potentially other species due to the occurrence of residues of POPs in natural aquatic systems. It is suggested that these relationships can be extended to other groups of organisms and chemicals.
authors.affiliation: Griffith School of Environment, Griffith University, Nathan Campus, Brisbane, Queensland 4111, Australia. D.Connell@griffith.edu.au
authors.forename: Des
authors.initials: D
authors.lastname: Connell
authors.forename: Jimmy
authors.initials: J
authors.lastname: Yu
mesh_terms: D000818:Animals; D054750:Ecotoxicology / Q000379:methods*; D004781:Environmental Exposure; D005399:Fishes; D007928:Lethal Dose 50; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects*; D008954:Models, Biological; D018570:Risk Assessment / Q000379:methods; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical