title: Evaluation of irradiated salivary gland function in patients with head and neck tumours treated with radiotherapy.
abstract: BACKGROUND
  Radiotherapy is an important treatment modality for head and neck tumours. One of its major drawbacks is post-treatment salivary gland hypofunction. This study was performed to objectively evaluate the salivary gland function in post-irradiated head and neck tumour patients.
  
  
  METHODS
  We performed a cross-sectional study of 30 patients with head and neck tumours who had received radiotherapy. Unstimulated and stimulated whole salivary flow rates were assessed in these 30 patients, and compared with those of 30 normal subjects. Unstimulated whole saliva was measured by the draining method, while the spitting method was used to collect stimulated whole saliva.
  
  
  RESULTS
  Both unstimulated and stimulated whole salivary flow rates were significantly reduced in the irradiated patients, compared with the normal subjects. This difference was statistically significant (p = 0.0001).
  
  
  CONCLUSIONS
  Salivary function in post-irradiated head and neck tumour patients (assessed as salivary flow rates) was significantly reduced compared with normal controls, suggesting marked salivary gland hypofunction.
authors.affiliation: Department of Otorhinolaryngology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. baharudin@kb.usm.my
authors.forename: A
authors.initials: A
authors.lastname: Baharudin
authors.forename: A
authors.initials: A
authors.lastname: Khairuddin
authors.forename: A
authors.initials: A
authors.lastname: Nizam
authors.forename: A R
authors.initials: AR
authors.lastname: Samsuddin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D012469:Salivary Glands / Q000378:metabolism / Q000528:radiation effects*; D012472:Salivation / Q000502:physiology / Q000528:radiation effects*; D013223:Statistics as Topic; D013997:Time Factors; D055815:Young Adult