The use of glucan as immunostimulant in the treatment of a severe case of chromoblastomycosis.
We report the case of an alternative treatment for a patient with a severe form of chromoblastomycosis that responded poorly to the traditional antifungal therapy. We hereby show, in this study, the improvement of lesions after treatment with itraconazole associated with an intramuscular administration of glucan. We observed that the regression of lesions was associated with an improvement of the cellular immune response. This favourable response that we observed suggests that the therapeutic regimen we used might be an option for the treatment of patients with a severe form of chromoblastomycosis.
Azevedo
Conceição de Maria Pedrozo e Silva
Cde M
Marques
Sirley Garcia
SG
Resende
Maria Aparecida
MA
Gonçalves
Azizedite Guedes
AG
Santos
Daniel Vagner de Castro Lima
DV
da Silva
Raimunda Ribeiro
RR
de Sousa
Maria da Glória Teixeira
Mda G
de Almeida
Sandro Rogerio
SR
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002862:Chromoblastomycosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005936:Glucans / Q000276:immunology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000276:Adjuvants, Immunologic; D000935:Antifungal Agents; D005936:Glucans; D017964:Itraconazole