title: Preparation and evaluation of inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites: performance and substantivity studies.
abstract: Herein we describe inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites to generate new sunscreen derivatives with optimized functional properties such as water resistance and skin adherence. Four cyclodextrins (alpha-, beta-, and gamma-cyclodextrin, and beta-dimethyl cyclodextrin) and two montmorillonites (sodium and alkylammonium) were investigated for encapsulating some commercial sunscreens. Our results reveal a good yield and inclusion products with functional properties obtained by using kneading technique on Eusolex 2292 and Eusolex 6007 in beta-cyclodextrin and solubilization method on Eusolex 6007 and NeoHeliopan MA in montmorillonite. In addition, molecular modeling studies indicated flexibility as important for the intercalation of the host molecule.
authors.affiliation: Departamento de Medicamentos, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Genoveva Luciana Negve
authors.initials: GL
authors.lastname: Coelho
authors.forename: Camila Braga
authors.initials: CB
authors.lastname: Dornelas
authors.forename: Kelen Carine Costa
authors.initials: KC
authors.lastname: Soares
authors.forename: Elisabete Pereira
authors.initials: EP
authors.lastname: dos Santos
authors.forename: André L
authors.initials: AL
authors.lastname: Vergnanini
authors.forename: Tereza Cristina
authors.initials: TC
authors.lastname: dos Santos
authors.forename: Carlos Rangel
authors.initials: CR
authors.lastname: Rodrigues
authors.forename: Helena Carla
authors.initials: HC
authors.lastname: Castro
authors.forename: Luiza R S
authors.initials: LR
authors.lastname: Dias
authors.forename: Lúcio Mendes
authors.initials: LM
authors.lastname: Cabral
mesh_terms: D000818:Animals; D001546:Bentonite / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D004355:Drug Stability; D005123:Eye / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D009883:Ophthalmic Solutions; D011817:Rabbits; D023422:Skin Irritancy Tests; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013473:Sunscreening Agents / Q000737:chemistry* / Q000633:toxicity; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D009883:Ophthalmic Solutions; D013473:Sunscreening Agents; D001546:Bentonite