title: Intraoperative assessment of an implantable electrode array for cavernous nerve stimulation.
abstract: BACKGROUND
  Erectile dysfunction remains a major functional complication of radical prostatectomy in the modern era despite surgical techniques to preserve the penile autonomic nerve supply.
  
  
  OBJECTIVE
  To develop and evaluate a neurostimulation system for cavernous nerve electrical stimulation for future use as a chronic implantation device that neurotrophically promotes erectile function recovery following radical prostatectomy.
  
  
  METHODS
  After radical retropubic prostatectomy, the neurovascular bundle was stimulated using a temporarily placed electrode array of an implantable neurostimulation system (20 Hz frequency, 260 micro seconds pulse width, 5 mA-60 mA amplitude up to 10 minutes), and penile circumference increases were measured.
  
  
  METHODS
  Increase in penile circumference. Results. Among 12 men (mean age 60.3 years) enrolled in this study, 6 (50%) demonstrated measurable increases in penile circumference in response to cavernous nerve stimulation. Among these six men, the mean increase was 5.0 mm (range 1.6 mm to 7.0 mm). Temporary surgical placement of the device was done with relative ease, and there was no evidence of injury to the neurovascular bundle. Conclusions. A chronic implantable nerve stimulation system for cavernous nerve stimulation having possible neuromodulatory effects on the recovery of penile erections after radical prostatectomy is feasible.
authors.affiliation: Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287-2411, USA. aburnett@jhmi.edu <aburnett@jhmi.edu>
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Burnett
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Teloken
authors.forename: Alberto
authors.initials: A
authors.lastname: Briganti
authors.forename: Todd
authors.initials: T
authors.lastname: Whitehurst
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
mesh_terms: D000368:Aged; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004567:Electrodes, Implanted; D004867:Equipment Design; D007172:Erectile Dysfunction / Q000503:physiopathology / Q000628:therapy*; D005240:Feasibility Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010410:Penile Erection / Q000502:physiology; D010413:Penis / Q000098:blood supply / Q000294:innervation*; D011183:Postoperative Complications / Q000503:physiopathology / Q000628:therapy*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery