title: The bite-raised condition in aged SAMP8 mice reduces the expression of glucocorticoid receptors in the dorsal and ventral hippocampus.
abstract: In the present study, we examined whether the effects induced by the bite-raised condition on glucocorticoid receptor (GR) expression differ between the dorsal and ventral hippocampus in SAMP8 mice. In the bite-raised condition, the number of GR-immunoreactive cells was significantly decreased in both the dorsal and ventral CA1 and dentate gyrus (DG) subfields of the hippocampus compared to control mice, as revealed by immunohistochemical analysis. The decrease in the number of GR-immunoreactive cells tended to be greater in the dorsal hippocampus than in the ventral hippocampus. Only in the DG subfield was there a significant difference in the number of GR-immunoreactive cells between the dorsal and ventral hippocampus. These findings suggest that in aged SAMP8 mice, the bite-raised condition decreases the number of GR-immunoreactive cells in both the dorsal and ventral hippocampus.
authors.affiliation: Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu, 501-0296, Japan. yukiko@dent.asahi-u.ac.jp
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ichihashi
authors.forename: Naonori
authors.initials: N
authors.lastname: Saito
authors.forename: Yoko
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Chika
authors.initials: C
authors.lastname: Kurata
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iinuma
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tamura
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Iwaku
authors.forename: Kin-Ya
authors.initials: KY
authors.lastname: Kubo
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002452:Cell Count; D049109:Cell Proliferation; D015536:Down-Regulation; D005938:Glucocorticoids / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008310:Malocclusion / Q000150:complications*; D008409:Mastication; D051379:Mice; D008817:Mice, Mutant Strains; D009474:Neurons / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013315:Stress, Psychological / Q000209:etiology* / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid