NOS1AP in schizophrenia.
NOS1AP is an attractive candidate gene for schizophrenia susceptibility. Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. Increased NOS1AP expression is observed in postmortem samples from individuals with schizophrenia. NOS1AP binds to neuronal nitric oxide synthase and synapsin, other candidate genes for schizophrenia, and may disrupt signal transduction through the N-methyl d-aspartate receptor complex, leading to hypofunctioning of that system. In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted.
Brzustowicz
Linda M
LM
Department of Genetics, Rutgers University, Life Sciences Building, Room 231, 145 Bevier Road, Piscataway, NJ 08854, USA. brzustowicz@biology.rutgers.edu
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D018703:Founder Effect; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012931:Social Environment
D048868:Adaptor Proteins, Signal Transducing; D005819:Genetic Markers; C488081:NOS1AP protein, human