title: Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, IA, 52242-1294, USA.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yahashiri
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Howell
authors.forename: Amnon
authors.initials: A
authors.lastname: Kohen
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000201:enzymology; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D008958:Models, Molecular; D008962:Models, Theoretical; D010084:Oxidation-Reduction; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013763:Tetrahydrofolates / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D013763:Tetrahydrofolates; C010920:dihydrofolate; C030371:5,6,7,8-tetrahydrofolic acid; D006859:Hydrogen; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase