title: Correlation of the International Prostate Symptom Score bother question with the Benign Prostatic Hyperplasia Impact Index in a clinical practice setting.
abstract: OBJECTIVE
  To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database.
  
  
  METHODS
  The BPH Registry and Patient Survey is a multicentre, longitudinal, observational database of management practices and patient outcomes in a population of patients with BPH in the USA, managed with watchful waiting or pharmacotherapy. Men enrolled in the BPH Registry who completed the IPSS BQ and the four-item BPH-II at enrolment were identified. The association between the IPSS BQ score and the BPH Impact Index was assessed using Spearman rank correlation.
  
  
  RESULTS
  At baseline (enrolment visit), 6439 men (mean age 66 years) completed the IPSS BQ and the BPH-II. The mean (sd) score of the IPSS BQ was 2.5 (1.4) and of the BPH-II was 2.8 (2.8). Based on responses to the BPH-II, at least half the men reported that their urinary symptoms were associated with physical discomfort, worry about their health, and bothersomeness. The IPSS BQ score was significantly correlated (P < 0.001) with the BPH-II (r = 0.68) and each of its four questions (physical discomfort, r = 0.52; worry about health, r = 0.53; bothersomeness of trouble with urination, r = 0.67; and time kept from usual activities, r = 0.44).
  
  
  CONCLUSIONS
  The IPSS BQ score has a strong and positive correlation with the BPH-II among men enrolled in the BPH Registry. The IPSS BQ is a convenient tool for assessing disease-specific quality of life when determining treatment strategies and evaluating treatment outcomes in men with BPH.
authors.affiliation: Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. moleary1@partners.org
authors.forename: Michael P
authors.initials: MP
authors.lastname: O'Leary
authors.forename: John T
authors.initials: JT
authors.lastname: Wei
authors.forename: Claus G
authors.initials: CG
authors.lastname: Roehrborn
authors.forename: Martin
authors.initials: M
authors.lastname: Miner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D010342:Patient Acceptance of Health Care; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000523:psychology / Q000628:therapy; D053448:Prostatism / Q000209:etiology* / Q000523:psychology / Q000628:therapy; D011788:Quality of Life; D011795:Surveys and Questionnaires / Q000592:standards