Proteomic analysis of a rat model of depression.
Major depression is one of the most disabling disorders, yet the pathogenesis of this mental disorder is poorly understood. The techniques of proteomics provide us with powerful tools, while the animal models of depression enable research that cannot be performed on humans due to practical difficulties or ethical reasons. In this review, we summarize the characteristics of some most commonly applied rat models of depression, and explore what could be done with novel proteomic approaches to offer an insight to the pathogenesis of major depression, biomarker establishment and drug development.
Mu
Jun
J
The First Affiliated Hospital of Chongqing Medical University, Department of Neurology, The Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Institute for Basic Medical Sciences, Chongqing, 400016, China. mujun0719@yahoo.com
Yang
Ze-Song
ZS
Xie
Peng
P
D000818:Animals; D015415:Biomarkers; D003863:Depression / Q000209:etiology*; D004195:Disease Models, Animal; D011506:Proteins / Q000032:analysis; D040901:Proteomics / Q000379:methods*; D051381:Rats
D015415:Biomarkers; D011506:Proteins