Transformation of ethyl alcohol to ethyl nitrite in acidified saliva: possibility of its occurrence in the stomach.
After taking alcoholic beverages, the ethanol is mixed with saliva and then gastric juice. As pH of gastric juice is around 2, the ethanol might be transformed to ethyl nitrite in the stomach by reacting with salivary nitrite. In this study, reactions between ethanol and nitrite in acidified saliva were investigated. The result indicates that nitrite in acidified saliva reacted with ethanol producing ethyl nitrite. It is discussed that ethyl nitrite might be formed in the stomach after drinking alcoholic beverages and that the ethyl nitrite might function as a donor of NO in intestinal and gastric tissues.
Takahama
Umeo
U
Department of Bioscience, Kyushu Dental College, Manazuru 2-6-1, Kitakyushu 803-8580, Japan. takahama@kyu-dent.ac.jp
Tanaka
Mariko
M
Hirota
Sachiko
S
D000143:Acids / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009573:Nitrites / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D013997:Time Factors
D000143:Acids; D009573:Nitrites; D000431:Ethanol; C032712:ethyl nitrite