Secretory unit of islet in transplantation (SUIT) and engrafted islet rate (EIR) indexes are useful for evaluating single islet transplantation.
The evaluation of engraftment is important to assess the success of islet transplantation, but it is complex because islet transplantation usually requires two or more donors to achieve euglycemia. Islet transplantation from NHBDs was evaluated using new assessment forms for the secretory unit of islet in transplantation (SUIT) and engrafted islet rate (EIR) indexes. Insulin independence was obtained when the SUIT index was more than 28, which might indicate that 28% of the beta-cell mass of a normal subject is required for insulin independence. Because the average EIR for a single transplantation is about 30, the percentage of engrafted islets following one transplantation is about 30%, assuming that a normal subject has 1 million islet equivalents. Although few cultured islet transplants have been performed, the increase of the SUIT and EIR indexes in patients who received cultured islets was significantly lower than in patients who received fresh islets, suggesting that fresh islets may be more effective than cultured islets. The SUIT and EIR indexes are thus considered to be useful values for evaluating islet transplantation, especially for single islet transplantation.
Noguchi
Hirofumi
H
Transplantation Unit, Kyoto University Hospital, Kyoto 606-8507, Japan. noguchih@med.nagoya-u.ac.jp
Yamada
Yuichiro
Y
Okitsu
Teru
T
Iwanaga
Yasuhiro
Y
Nagata
Hideo
H
Kobayashi
Naoya
N
Hayashi
Shuji
S
Matsumoto
Shinichi
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001926:Brain Death; D002102:Cadaver; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016381:Islets of Langerhans Transplantation; D014019:Tissue Donors
D001786:Blood Glucose; D007328:Insulin