Microvesicles as immune orchestra conductors.
In this issue of Blood, Sprague and colleagues report that platelet-derived membrane vesicles (PDMVs) orchestrate an immune response sufficient to deliver CD154 signals, which stimulate antigen-specific IgG production and modulate germinal-center formation, by cooperating with responses elucidated by CD4+ T cells.
Ratajczak
Mariusz Z
MZ
Stem Cell Institute at James Graham Brown Cancer Center.