title: Efficient and eco-friendly preparation of 4-methyl-5-formyl-thiazole.
abstract: 4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil,was prepared in good yield by Pd/BaSO(4) catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.
authors.affiliation: The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Bai
authors.forename: Yaowu
authors.initials: Y
authors.lastname: Sha
authors.forename: Ge
authors.initials: G
authors.lastname: Meng
mesh_terms: D001466:Barium Sulfate / Q000737:chemistry; D002511:Cephalosporins / Q000737:chemistry; D004463:Ecology / Q000379:methods; D010165:Palladium / Q000737:chemistry; D010316:Particle Size; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors
chemical_list: C529844:4-methyl-5-formyl-thiazole; D002511:Cephalosporins; D013844:Thiazoles; D001466:Barium Sulfate; D010165:Palladium; C057710:cefditoren pivoxil