title: Morphological changes due to Lead exposure and the influence of DMSA on the gill tissues of the freshwater fish, Catla catla.
abstract: Catla catla fingerlings were reared in freshwater and exposed to 15.5 ppm concentration of lead for 60 days. The morphological changes on the gill of the C. catla fingerlings due to lead intoxication and the effect of DMSA (meso 2,3-dimercaptosuccinic acid) on the affected tissues were observed using Scanning Electron Microscope. It has been found that the lead treated gill tissues showed certain marked changes, such as cell hypertrophy, alteration in the lamellar surfaces, epithelial hyperplasia and the fusion of adjacent lamellae. The antidote DMSA treatment reduces the toxic effects and helps the recovery of gill tissue and its return to the level of the control/normal.
authors.affiliation: Department of Physics, Annamalai University, Annamalai Nagar 608 002, Tamilnadu, India. plrmpl@hotmail.com
authors.forename: P L R M
authors.initials: PL
authors.lastname: Palaniappan
authors.forename: Selvi
authors.initials: S
authors.lastname: Sabhanayakam
authors.forename: N
authors.initials: N
authors.lastname: Krishnakumar
authors.forename: M
authors.initials: M
authors.lastname: Vadivelu
mesh_terms: D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D003530:Cyprinidae / Q000378:metabolism*; D004781:Environmental Exposure; D005618:Fresh Water; D005880:Gills / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D007854:Lead / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D008855:Microscopy, Electron, Scanning / Q000379:methods / Q000662:veterinary; D004113:Succimer / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000931:Antidotes; D007854:Lead; D004113:Succimer