title: Ischemia modified albumin, a marker of acute ischemic events: a pilot study.
abstract: Ischemia modified albumin (IMA) is a relatively new marker for evaluating patients with cardiac ischemia. Data are emerging on its potential role in non-cardiac ischemic events. In this pilot study we evaluated the utility of IMA in diagnosing acute coronary syndromes (ACS), assessed its role in the diagnosis of non-cardiac ischemia, and correlated its efficacy with troponin T (TnT). Serum levels of IMA were measured in 89 sequential patients who presented to the emergency room with chest pain for which serum TnT was ordered. The patients were classified into 4 groups based on their IMA and TnT results and discharge diagnoses. The data were analyzed with Fischer's exact test. Multivariate logistic regression analysis relating acute coronary syndrome (ACS) to the combination of TnT and IMA was also performed. The results showed that IMA was a useful marker for the diagnosis of ACS. There was a significant relationship between TnT and IMA (p = 0.032), suggesting that both these biomarkers added significant information about the presence of ACS (p = 0.028) and may be useful for triage of patients who present to the emergency room with chest pain. Serum IMA was also increased in a small proportion of patients with symptoms of stroke, suggesting that it should be considered a marker of acute ischemic events and not specific for cardiac ischemia.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Louisville Medical School, Louisville, Kentucky, USA.
authors.forename: Sameer S
authors.initials: SS
authors.lastname: Talwalkar
authors.forename: Marjorie
authors.initials: M
authors.lastname: Bon Homme
authors.forename: James J
authors.initials: JJ
authors.lastname: Miller
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Elin
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002637:Chest Pain / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis*; D010865:Pilot Projects; D012189:Retrospective Studies; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism*; D020521:Stroke / Q000097:blood / Q000175:diagnosis; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D020107:Troponin T