title: Interaction of tea catechins with lipid bilayers investigated by a quartz-crystal microbalance analysis.
abstract: The quartz-crystal microbalance (QCM) technique was applied to investigate the interaction of tea catechins with lipid bilayers. The association constants obtained from the frequency changes of QCM revealed that (-)epicatechin gallate and (-)epigallocatechin gallate interacted with 1,2-dimyristoyl-sn-glycero-3-phosphocholine ca. 1000 times more strongly than (-)epicatechin and (-)epigallocatechin. The results exhibited good correlation with the strength of biological activity.
authors.affiliation: Laboratory of Functional Food Science and Global COE Program, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
authors.forename: Miya
authors.initials: M
authors.lastname: Kamihira
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nakazawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kira
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mizutani
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000327:Adsorption; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry*; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D011791:Quartz / Q000737:chemistry*; D013662:Tea / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D013662:Tea; D011791:Quartz; D002392:Catechin; D004134:Dimyristoylphosphatidylcholine