title: Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: a combined structural and resting-state functional MRI study.
abstract: Resting-state functional magnetic resonance imaging (MRI), have revealed coactivation in a distributed network that characterizes the default-mode in the human brain. However, details from resting-state imaging in amnestic type mild cognitive impairment (aMCI) is poorly understand. Regional homogeneity, which characterizes low-frequency blood oxygenation level dependent fluctuation, after statistically controlling for the regional atrophy and age in resting-state, were examined and compared between the two groups. When regional atrophy was controlled, decreased regional homogeneity in posterior cingulate cortex and precuneus still remained significant in aMCI patients. In addition the aMCI subjects displayed several regions of increased homogeneity, typically in right inferior parietal lobule, right fusiform gyrus and bilateral putamen. The impairment of posterior cingulate and precuneus could be an important marker to distinguish aMCI from healthy aging in the resting-state. Moreover, the increased regional homogeneity changes would be consistent with compensation for damage to the medial temporal regions and limbic structures, perhaps by recruitment of alternative regions.
authors.affiliation: School of Clinical Medicine, Southeast University, Nanjing 210009, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Bai
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Shi
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.forename: Wanlin
authors.initials: W
authors.lastname: Zhu
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology / Q000502:physiology; D000647:Amnesia / Q000175:diagnosis* / Q000503:physiopathology*; D001284:Atrophy / Q000175:diagnosis / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*; D010296:Parietal Lobe / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011699:Putamen / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D012016:Reference Values; D013702:Temporal Lobe / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology