title: The effect of periodontal treatment on metabolic control of type 1 diabetes mellitus.
abstract: The objective of this investigation was to study the effect of nonsurgical periodontal treatment, with or without systemic administration of doxycycline, on the metabolic control of patients with type 1 diabetes. Sixty type 1 diabetic subjects with moderate to severe periodontitis were recruited. Periodontal parameters were measured, and blood samples were obtained to evaluate glycosylated hemoglobin (HbA1c). Group 1 (30 patients) was treated with scaling, root planning, and chlorhexidine rinses for 3 months in conjunction with systemic administration of doxycycline (100 mg once a day for 15 days). Group 2 (30 patients) received the same periodontal treatment but without the use of doxycycline. The paired Student t-test was used to detect differences between glycosylated hemoglobin means before and 3 months after periodontal treatment in group 1 and group 2 separately. Changes in mean HbA1c after treatment were 0.07% in group 1 and -0.06% in group 2, which were not statistically significant after 3 months. Significant changes were not found even in patients with the best response to periodontal treatment. Periodontal treatment in type 1 diabetic patients after 3 months follow-up did not improve metabolic control of diabetes as measured by glycosylated hemoglobin.
authors.affiliation: Medically Compromised Patients Department, School of Dentistry, University of Valencia, Valencia, Spain. fernando.llambes@gmail.com
authors.forename: Fernando
authors.initials: F
authors.lastname: Llambés
authors.forename: Francisco-Javier
authors.initials: FJ
authors.lastname: Silvestre
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernández-Mijares
authors.forename: Rami
authors.initials: R
authors.lastname: Guiha
authors.forename: Raúl
authors.initials: R
authors.lastname: Caffesse
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D012534:Dental Scaling; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D010518:Periodontitis / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine; D004318:Doxycycline; D019270:Fructosamine; D006442:Glycated Hemoglobin; D009067:Mouthwashes