title: Inductive heat property of Fe3O4/polymer composite nanoparticles in an ac magnetic field for localized hyperthermia.
abstract: The magnetite (Fe(3)O(4)) nanoparticles were prepared by coprecipitation of Fe(3+) and Fe(2+) with an aqueous NaOH solution. The Fe(3)O(4)/polyaniline (PANI) magnetic composite nanoparticles with a core-shell structure with a diameter of 30-50 nm were prepared via an in situ polymerization of aniline in an aqueous solution containing the Fe(3)O(4) magnetic fluid. The inductive heat property of Fe(3)O(4)/PANI composite nanoparticles in an alternating current (ac) magnetic field was investigated. The potential of Fe(3)O(4)/PANI nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization, M(s), and coercivity, H(c), are 50.05 emu g(-1) and 137 Oe for Fe(3)O(4) nanoparticles and 26.34 emu g(-1) and 0 Oe for Fe(3)O(4)/PANI composite nanoparticles, respectively. Exposed in the ac magnetic field for 29 min, the temperatures of physiological saline suspensions containing Fe(3)O(4) nanoparticles or Fe(3)O(4)/PANI composite nanoparticles are 63.6 degrees C and 52.4 degrees C, respectively. The Fe(3)O(4)/PANI composite nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China. dlzhao@mail.buct.edu.cn
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Zhao
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Zhang
authors.forename: Xian-Wei
authors.initials: XW
authors.lastname: Zeng
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Xia
authors.forename: Jin-Tian
authors.initials: JT
authors.lastname: Tang
mesh_terms: D004574:Electromagnetic Fields; D005290:Ferric Compounds / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use*; D006358:Hot Temperature; D007036:Hypothermia, Induced / Q000295:instrumentation* / Q000379:methods*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide