title: Outcome analysis of breast cancer patients receiving breast-conserving surgery in Southern Italy.
abstract: The purpose of the current analysis was to evaluate the outcome of patients enrolled at the National Cancer Institute of Naples between 1997 and 2000, who underwent breast-conserving surgery. Between January 1997 and December 2000, 946 patients had been diagnosed with T1 or T2 (<3 cm) breast carcinoma. At the time of the present analysis (31-12-2005), all patients had been followed for >5 years. A Cox proportional hazards model was performed. Overall, 7-year Locoregional Relapse-free survival (LRFS) and Distant Relapse-free Survival (DRFS) rates were 95.9% and 88.4%, respectively. Seven-year DRFS was 91.2% and 79.3% in T1 and T2 stage, respectively (p<0.0001). Multivariate Cox analysis indicated that number of positive lymph-nodes and hormone receptor status were significantly associated with prognosis. Our findings confirm that early diagnosed breast cancer, treated with breast-conserving surgery, is associated with a very good prognosis in patients referred to an Institution which may be considered as representative of similar Cancer Institutes of Southern Italy. The risk of local relapse was found to be very low (4%), although a longer follow-up is needed to draw definitive conclusions.
authors.affiliation: Unit of Medical Oncology A, National Cancer Institute of Naples, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Frasci
authors.forename: A
authors.initials: A
authors.lastname: Crispo
authors.forename: G
authors.initials: G
authors.lastname: D'Aiuto
authors.forename: M
authors.initials: M
authors.lastname: Barba
authors.forename: M
authors.initials: M
authors.lastname: Rinaldo
authors.forename: M
authors.initials: M
authors.lastname: De Marco
authors.forename: M
authors.initials: M
authors.lastname: Grimaldi
authors.forename: I
authors.initials: I
authors.lastname: Capasso
authors.forename: G
authors.initials: G
authors.lastname: Botti
authors.forename: M
authors.initials: M
authors.lastname: Di Bonito
authors.forename: M
authors.initials: M
authors.lastname: Montella
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D003710:Demography; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007558:Italy; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D016896:Treatment Outcome