[Clinical features and prognosis of cerebral venous thrombosis].
OBJECTIVE
To explore the diagnosis,therapy and prognosis of cerebral venous thrombosis (CVT).


METHODS
Twenty-two CVT patients were reviewed. The onset age, clinical manifestations, imaging, treatment, and prognosis were analyzed.


RESULTS
Their age ranged from 15 to 58 (mean 33.0+/-8.8) years. Nine were males and 13 were females (1:1.4), 41% of whom were women of childbearing age.This disease occurred rapidly, and the relative pathogeny could be found in most patients (59%), and the hypercoagulative state was the commonest one.The clinical manifestations were variable. Most patients had symptoms and signs of intracranial hypertension(86%), accompanied with or without focal neurological dysfunction and seizures. Disorders of consciousness were found in some sever conditions.The cerebrospinal fluid (CSF) pressure was significantly increased, and the quantity of proteins or white blood cells in CSF was nearly normal.The occluded dural sinus and the clot could be visualised directly by means of magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) or digital subtraction angiogrophy (DSA).After dehydration,anticoagulation,application of adrenal cortex hormone and etilogical treatment,9 patients improved,7 nearly cured, 2 had no changes,1 had cerebral hemorrhage, and 3 died.


CONCLUSIONS
CVT should be suspected when patients show manifestation of intracranial hypertension and/or focal neurological dysfunction and seizures. MRI and MRA are efficient choices for the early diagnosis of CVT. Early diagnosis and anticoagulation with heparin are keys to good prognosis.
Yang
Jie
J
Department of Neurology,Xiangya Hospital,Central South University, Changsha, China. yangjie6523@163.com
Zhou
Jin-xia
JX
Zhou
Zhi-wen
ZW
Li
Guo-liang
GL
Yang
Xiao-su
XS
D000293:Adolescent; D000328:Adult; D015901:Angiography, Digital Subtraction; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis* / Q000188:drug therapy; D015912:Thrombolytic Therapy
D000925:Anticoagulants; D006493:Heparin