title: Pharmacological studies on Indian black tea (leaf variety) in acute and chronic inflammatory conditions.
abstract: Infusions of Indian black tea (BTI), when administered orally, produced significant inhibition of rat paw oedema, induced with carrageenin (pre and post treatment) and arachidonic acid. BTI was also found to inhibit peritoneal capillary permeability and caused a marked reduction of lipopolysaccharide induced PGE(2) generation. In these models, the observed antioedema effect was similar to that of BW755C (a dual inhibitor of cyclooxygenase and 5-lipoxygenase enzymes). BTI was found to scavenge superoxide and hydroxyl radicals, and also protected rat erythrocytes from the damaging effects of hydrogen peroxide. In chronic studies, BTI inhibited granuloma formation along with the reduction of both lipid peroxidation and hydroxyproline content (in the granuloma tissue). Significant antiarthritic activity was observed with regular administration of BTI in the Freund's adjuvant induced model of arthritis. Chronic treatment with BTI (in arthritic rats) resulted in a decrease of paw diameter and tissue lipid peroxidation, along with a restoration of GSH, catalase and superoxide dismutase levels.
authors.affiliation: Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Roy
authors.forename: K T Mani Senthil
authors.initials: KT
authors.lastname: Kumar
authors.forename: Sanmoy
authors.initials: S
authors.lastname: Karmakar
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Pal
authors.forename: Samir K
authors.initials: SK
authors.lastname: Samanta
authors.forename: Dipan
authors.initials: D
authors.lastname: Adhikari
authors.forename: Tuhinadri
authors.initials: T
authors.lastname: Sen
mesh_terms: D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine / Q000494:pharmacology; D019342:Acetic Acid; D000208:Acute Disease; D000818:Animals; D016718:Arachidonic Acid; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000276:immunology; D002908:Chronic Disease; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D013662:Tea / Q000737:chemistry*
chemical_list: D008070:Lipopolysaccharides; D010936:Plant Extracts; D013662:Tea; D016718:Arachidonic Acid; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D019342:Acetic Acid