Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB.
The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression.
Kalinina
E V
EV
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences. kevsan@orc.ru
Chernov
N N
NN
Saprin
A N
AN
Kotova
Y N
YN
Gavrilova
Y A
YA
Chermnykh
N S
NS
Shcherbak
N P
NP
D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics*; D013879:Thioredoxins / Q000235:genetics* / Q000378:metabolism
D007527:Isoenzymes; D013879:Thioredoxins