LINGO-1 and its role in CNS repair.
LINGO-1 is selectively expressed in the CNS on both oligodendrocyte precursor cells (OPCs) and neurons. Its expression is developmentally regulated in the normal CNS, as well as up-regulated in human or rat models of neuropathologies. LINGO-1 functions as a negative regulator of oligodendrocyte differentiation and myelination, neuronal survival and axonal regeneration. Across diverse animal CNS disease models, targeted LINGO-1 inhibition was found to promote neuron and oligodendrocyte survival, axon regeneration, oligodendrocyte differentiation, remyelination and improved functional recovery. The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases.
Mi
Sha
S
Biogen Idec Inc., 14 Cambridge Center, Cambridge, MA 02142, United States. sha.mi@biogenidec.com
Sandrock
Alfred
A
Miller
Robert H
RH
D000818:Animals; D001369:Axons / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009928:Organ Specificity; D014945:Wound Healing
D009419:Nerve Tissue Proteins