Pharmacokinetics and pharmacodynamics of meloxicam in piglets.
The pharmacokinetics and pharmacodynamics of meloxicam in piglets (16-23 days old) were studied using a stratified parallel group design. One group (n = 13) received 0.4 mg/kg meloxicam intravenously, while the other group (n = 12) received physiological saline solution. A carrageenan-sponge model of acute inflammation was used to evaluate the effects of meloxicam. The plasma clearance was low (0.061 L/kg/h), the volume of distribution was low (0.19 L/kg) and the elimination half-life was short (2.7 h). At most time points, the mean concentration of meloxicam in plasma exceeded the concentrations in exudate indicating a limited accumulation of the drug at the site of the inflammation. There were significant differences between the groups in the exudate prostaglandin E2 (PGE2) concentration, but the inhibition of PGE2 in the meloxicam group was limited. The inhibition of thromboxane B(2) (TXB2) production in serum in the meloxicam group was extensive, but of shorter duration than the PGE2 inhibition in exudate.
Fosse
T K
TK
Department of Food Safety and Infection Biology, The Norwegian School of Veterinary Science, Oslo, Norway. torunn.fosse@veths.no
Haga
H A
HA
Hormazabal
V
V
Haugejorden
G
G
Horsberg
T E
TE
Ranheim
B
B
D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D015232:Dinoprostone / Q000037:antagonists & inhibitors; D005260:Female; D006207:Half-Life; D008297:Male; D000077239:Meloxicam; D008657:Metabolic Clearance Rate; D013552:Swine; D013843:Thiazines / Q000493:pharmacokinetics* / Q000494:pharmacology; D013844:Thiazoles / Q000493:pharmacokinetics* / Q000494:pharmacology; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D013928:Thromboxane A2; D015232:Dinoprostone; D000077239:Meloxicam