title: Serum hyaluronidase levels in patients with aneurysmal subarachnoid haemorrhage.
abstract: BACKGROUND
  The purpose of this study was to investigate the time course(s) of the serum hyaluronidase levels in patients with aneurysmal subarachnoid haemorrhage and to show whether there is a correlation between symptomatic vasospasm and serum levels of hyaluronidase.
  
  
  METHODS
  This prospective, open, non-randomised clinical study consisted of 20 patients with aneurysmal subarachnoid haemorrhage, and eight patients with normotensive hydrocephalus who served as the control group. Serum hyaluronidase levels were detected within the first three days, days five and seven after aneurysmal subarachnoid haemorrhage, and the results were compared with those from the control group. The results were also compared with those of the clinical parameters, including the patient's outcome at six months and symptomatic vasospasm.
  
  
  RESULTS
  Mean serum hyaluronidase levels were higher on days five and seven, and comparisons with either day five (p-value is 0.001) and/or day seven (p-value is 0.00001) showed a statistical difference between subarachnoid haemorrhage and controls. However, no relationship was found between elevated serum hyaluronidase levels and the clinical parameters including symptomatic vasospasm (p-value is greater than 0.05) and outcome at sixth months (p-value is greater than 0.05).
  
  
  CONCLUSIONS
  Our results indicate that serum hyaluronidase is elevated in the acute stage(s) of subarachnoid haemorrhage; however, no difference was found between serum hyaluronidase levels and subarachnoid haemorrhage severity. Clinical studies with larger population of patients with aneurysmal subarachnoid haemorrhage are required.
authors.affiliation: Department of Biochemistry, Taksim Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Isman
authors.forename: M
authors.initials: M
authors.lastname: Kucur
authors.forename: T
authors.initials: T
authors.lastname: Tanriverdi
authors.forename: T
authors.initials: T
authors.lastname: Kacira
authors.forename: G Z
authors.initials: GZ
authors.lastname: Sanus
authors.forename: R
authors.initials: R
authors.lastname: Kemerdere
authors.forename: H
authors.initials: H
authors.lastname: Hanimoglu
authors.forename: M Y
authors.initials: MY
authors.lastname: Kaynar
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000097:blood*; D002532:Intracranial Aneurysm / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000097:blood*; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000097:blood
chemical_list: D006821:Hyaluronoglucosaminidase