title: Outcome following surgical closure of patent ductus arteriosus in very low birth weight infants in neonatal intensive care unit.
abstract: OBJECTIVE
  The aims of this study were to determine the factors affecting the outcome of patent ductus arteriosus ligation in very low birth weight infants (VLBWI) and demonstrate the safety of PDA ligation in VLBWI performed in the neonatal intensive care unit (NICU).
  
  
  METHODS
  From October 1994 to July 2006, medical records of 94 VLBWI weighing <1,500 g who underwent PDA ligation in the NICU of Samsung Medical Center were reviewed retrospectively. Factors affecting the final outcome of PDA ligation were evaluated by dividing the infants into 3 groups according to mortality and major morbidities as follows: mortality group (Mo), major morbidity group (Mb), and no major morbidity group (NM).
  
  
  RESULTS
  In the Mo group, birth weight was significantly lower and the preoperative mean FiO2 and mean dopamine dose were significantly higher than those in the other 2 groups. There was no significant difference in gestational age, incidence of RDS, number of courses of indomethacin, surgery-related factors, including weight and age at surgery, perioperative vital signs, and complications after surgery between the 3 groups. During surgery in the NICU, there were no significant hemodynamic instability or serious acute complications.
  
  
  CONCLUSIONS
  The factors affecting the outcome of surgery in VLBWI are not the factors related to surgery but the preoperative conditions related to the underlying prematurity. PDA ligation of VLBWI performed in the NICU is safe without serious complications.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Korea.
authors.forename: Ga Yeun
authors.initials: GY
authors.lastname: Lee
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Sohn
authors.forename: Myo Jing
authors.initials: MJ
authors.lastname: Kim
authors.forename: Ga Won
authors.initials: GW
authors.lastname: Jeon
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Shim
authors.forename: Yun Sil
authors.initials: YS
authors.lastname: Chang
authors.forename: June
authors.initials: J
authors.lastname: Huh
authors.forename: I-Seok
authors.initials: IS
authors.lastname: Kang
authors.forename: Ji-Hyuk
authors.initials: JH
authors.lastname: Yang
authors.forename: Tae-Gook
authors.initials: TG
authors.lastname: Jun
authors.forename: Pyo Won
authors.initials: PW
authors.lastname: Park
authors.forename: Won Soon
authors.initials: WS
authors.lastname: Park
authors.forename: Heung Jae
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D008026:Ligation / Q000379:methods*; D016896:Treatment Outcome