Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.
IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.
Ndhlovu
Lishomwa C
LC
Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 94110, USA. lishomwa.ndhlovu@ucsf.edu
Chapman
Joan M
JM
Jha
Aashish R
AR
Snyder-Cappione
Jennifer E
JE
Pagán
Moraima
M
Leal
Fabio E
FE
Boland
Brigid S
BS
Norris
Philip J
PJ
Rosenberg
Michael G
MG
Nixon
Douglas F
DF
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis*; D019562:Viral Load; D014766:Viremia / Q000276:immunology / Q000821:virology
D020381:Interleukin-17