title: Aplysinoplides A-C, cytotoxic sesterterpenes from the marine sponge Aplysinopsis digitata.
abstract: Three sesterterpenoids, aplysinoplides A-C (1- 3), were isolated from the marine sponge Aplysinopsis digitata. Their structures were determined on the basis of spectroscopic data. They exhibited cytotoxic activity against P388 mouse leukemia cells.
authors.affiliation: Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Ueoka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Shinobu
authors.initials: S
authors.lastname: Fujii
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes; C531294:aplysinoplide A; C531295:aplysinoplide B; C531296:aplysinoplide C