title: Preparation and in vitro bioactivity of novel merwinite ceramic.
abstract: The ceramic of merwinite (Ca3MgSi2O8) was prepared by sintering sol-gel-derived merwinite powder compacts. The mechanical properties and the coefficient of thermal expansion (CTE) of the merwinite ceramic were determined. In vitro bioactivity of the merwinite ceramics was evaluated. Our results showed that the sintered body was single-phase merwinite ceramic, and that its bending strength, fracture toughness and Young's modulus were approximately 151 MPa, 1.72 MPa m(1/2) and 31 GPa, respectively. The CTE of the ceramic was 9.87 x 10(-6) degrees C(-1) and close to that for the Ti-6Al-4V alloy (9.80 x 10(-6) degrees C(-1)). Immersion of the sintered body in simulated body fluid induced surface precipitation of Ca-P rich layers. Cell culture experiment results confirmed that soluble ionic products from merwinite dissolution significantly stimulated osteoblast proliferation, and osteoblasts adhered and spread well on merwinite ceramic surfaces.
authors.affiliation: School of Materials Science and Engineering, Sichuan University, Chengdu, 610064, People's Republic of China. gloujun123@gmail.com
authors.forename: Jun
authors.initials: J
authors.lastname: Ou
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Kang
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.forename: Xianchun
authors.initials: X
authors.lastname: Chen
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.forename: Rongchi
authors.initials: R
authors.lastname: Xiao
authors.forename: Guangfu
authors.initials: G
authors.lastname: Yin
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D018786:Bone Substitutes / Q000008:administration & dosage* / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry* / Q000494:pharmacology*; D019245:Compressive Strength; D004548:Elasticity; D006244:Hardness; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength
chemical_list: D018786:Bone Substitutes