title: Assessment of serum thyroid hormone concentrations in lambs with selenium deficiency myopathy.
abstract: OBJECTIVE
  To assess changes in serum concentrations of thyroid hormones associated with selenium deficiency myopathy in lambs.
  
  
  METHODS
  35 lambs with selenium deficiency myopathy and 30 healthy lambs.
  
  
  METHODS
  Blood samples were collected via jugular venipuncture from lambs with selenium deficiency myopathy and healthy lambs. Activities of markers of selenium deficiency myopathy (erythrocyte glutathione peroxidase [GSH-Px] and plasma creatine kinase [CK]) and serum thyroid-stimulating hormone (TSH) and total thyroxine (tT(4)) and total triiodothyronine (tT(3)) concentrations were assessed; values in affected lambs were compared with those in healthy lambs. Correlations of erythrocyte GSH-Px and plasma CK activities with serum concentrations of TSH, tT(4), and tT(3) were investigated, and the tT(3):tT(4) concentration ratio was evaluated.
  
  
  RESULTS
  Compared with findings in healthy lambs, erythrocyte GSH-Px activity, serum tT(3) concentration, and tT(3):tT(4) concentration ratio were significantly decreased and serum concentrations of tT(4) and TSH and the activity of plasma CK were significantly increased in affected lambs. Analysis revealed a significant negative correlation in the affected group between erythrocyte GSH-Px activity and each of the following: plasma CK activity (r = -0.443), serum TSH concentration (r = -0.599), serum tT(4) concentration (r = -0.577), and serum tT(3) concentration (r = -0.621).
  
  
  CONCLUSIONS
  Results suggested that notable changes in circulating amounts of thyroid hormones develop in association with selenium deficiency in lambs. Such alterations in thyroid hormone metabolism may be involved in the high incidence of disorders, such as stillbirths and neonatal deaths, in selenium-deficient flocks.
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, PO Box 57155-1177, Urmia, Iran.
authors.forename: Bahram
authors.initials: B
authors.lastname: Dalir-Naghadeh
authors.forename: Siamak Asri
authors.initials: SA
authors.lastname: Rezaei
mesh_terms: D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D009135:Muscular Diseases / Q000097:blood / Q000662:veterinary*; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*; D018709:Statistics, Nonparametric; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D005979:Glutathione Peroxidase; D003402:Creatine Kinase; D012643:Selenium; D013974:Thyroxine