title: Variable biotherapeutic effects of Lactobacillus acidophilus isolates on orogastric and systemic candidiasis in immunodeficient mice.
abstract: Two commercially available isolates of Lactobacillus acidophilus (NCFM and LA-1) were compared for their capacities to protect immunodeficient bg/bg-nu/un and bg/bg-nu/+ mice from candidiasis. L. acidophilus NCFM prolonged survival of adult and neonatal bg/bg-nu/nu mice, inhibited disseminated candidiasis in both mouse strains, suppressed weight loss associated with Candida albicans infection in bg/bg-nu/nu females, but did not decrease the severity or the incidente of orogastric candidiasis in gnotobiotic mice. L. acidophilus LA-1 suppressed numbers of C. albicans in the alimentary tracts of bg/bg-nu/+ mice and reduced the severity of mucosal candidiasis in bg/bg-nu/nuand bg/bg-nu/+ mice; however, L. acidophilus LA-1 did not improve the survival of bg/bg-nu/nu mice after oral challenge (colonization) with C. albicansand it was associated with lethality in gnotobiotic adult female bg/bg-nu/nu mice. These results demonstrate that the two isolates of L. acidophilus differed in their capacity to protect immunodeficient mice from candidiasis.
authors.affiliation: Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin, USA. balish@surgery.wisc.edu.
authors.forename: R D
authors.initials: RD
authors.lastname: Wagner
authors.forename: T
authors.initials: T
authors.lastname: Warner
authors.forename: L
authors.initials: L
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Farmer
authors.forename: M
authors.initials: M
authors.lastname: Dohnalek
authors.forename: M
authors.initials: M
authors.lastname: Hilty
authors.forename: E
authors.initials: E
authors.lastname: Balish