title: Natural history of primary biliary cirrhosis.
abstract: Primary biliary cirrhosis is an insidious disease that progresses through the clinical phases: preclinical, asymptomatic, symptomatic, and liver insufficiency. The outlook of patients diagnosed with PBC has improved significantly over the past 2 decades because more patients are being diagnosed earlier in the disease process and being treated with UDCA. A need remains to better define and predict the course of symptomatic and asymptomatic patients on and off UDCA in order to better evaluate outcomes of clinical trials.
authors.affiliation: Department of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9151, USA. marlyn.mayo@utsouthwestern.edu <marlyn.mayo@utsouthwestern.edu>
authors.forename: Marlyn J
authors.initials: MJ
authors.lastname: Mayo
mesh_terms: D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid