Diffuse placoid choroidopathy in a patient with common variable immunodeficiency.
Unilateral diffuse placoid choroidopathy can be seen in the setting of common variable immunodeficiency (CVID). A 55-year-old woman with a 20-year history of CVID presented with multiple hypopigmented placoid lesions in the right eye. Diffuse lymphadenopathy led to lymph node biopsies (mediastinal and axillary) and angiotensin-converting enzyme and serum calcium level determination, which were all normal. CVID, the most common type of significant hypogammaglobulinemia, may be associated with a placoid choroidopathy. The cause of this CVID choroidopathy is unclear at this time, but may be secondary to lymphoid hyperplasia or granulomatous disease.
McCannel
Colin A
CA
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota55905, USA. mccannel.colin@mayo.edu
Pulido
Jose S
JS
D015862:Choroid Diseases / Q000150:complications* / Q000473:pathology*; D017074:Common Variable Immunodeficiency / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged