title: Pharmacokinetics of buprenorphine after intravenous administration of clinical doses to dogs.
abstract: The purpose of this study was to evaluate plasma concentrations and pharmacokinetic parameters of buprenorphine in dogs following intravenous (IV) administration of clinical doses of the opioid. An IV bolus of 0.02mg/kg buprenorphine was administered to six healthy Beagles and blood samples were collected through a jugular catheter before and at 1, 5, 10, 15, 20, 30 and 45 min, and 1, 2, 4, 6, 8 and 12h after administration. Plasma buprenorphine concentrations, measured using a commercial radioimmunoassay (RIA), decreased following a three-exponential curve. The two distribution and the elimination half-lives were 2.9+/-1.8min, 16.5+/-3.7min, and 266.6+/-82.0min, respectively; the clearance was 329.6+/-62.2mL/min, and the steady state volume of distribution was 83.7+/-26.5L. The results demonstrated the feasibility of the RIA assay to analyse buprenorphine in dog plasma samples. Following IV administration buprenorphine showed a three-compartment kinetic profile, as has been described previously in humans, rabbits and cats. The relationship between plasma concentrations and dynamic effects in dogs remains to be established.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Autonomous University of Barcelona (U.A.B), 08193 Bellaterra, Barcelona, Spain. anna.andaluz@uab.es
authors.forename: Anna
authors.initials: A
authors.lastname: Andaluz
authors.forename: Xavier
authors.initials: X
authors.lastname: Moll
authors.forename: Rosario
authors.initials: R
authors.lastname: Abellán
authors.forename: Rosa
authors.initials: R
authors.lastname: Ventura
authors.forename: Marcellí
authors.initials: M
authors.lastname: Carbó
authors.forename: Laura
authors.initials: L
authors.lastname: Fresno
authors.forename: Félix
authors.initials: F
authors.lastname: García
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D007275:Injections, Intravenous; D008297:Male
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine