title: Fistula-in-ano: advances in treatment.
abstract: BACKGROUND
  Several techniques have been described for the management of fistula-in-ano, but all carry their own risks of recurrence and incontinence. Technology has evolved over the past 2 decades that may enable surgeons to deal with this troublesome issue with greater success. This review summarizes the history of fistula-in-ano management, the current techniques available, and describes new technologies.
  
  
  METHODS
  Medline searches were performed using the PubMed, Ovid, Embase, Cochrane, and Google Scholar databases to identify articles reporting on fistula-in-ano management using surgery alone, fibrin glues, and fistula plugs. Forty-one articles reporting on the history of fistula-in-ano management and the use of new technologies were included.
  
  
  RESULTS
  Conventional fistula surgery techniques have their place, but new technologies such as fibrin glues and the anal fistula plugs offer an alternative approach, with initial studies reporting good success rates.
  
  
  CONCLUSIONS
  New technologies provide promising alternatives to traditional methods of management. There is, however, a real need for high-quality randomized control trials.
authors.affiliation: Department of Biosurgery and Surgical Technology, St. Mary's Hospital, Norfolk Place, London W2 1NY, UK. s.deeba@imperial.ac.uk
authors.forename: Samer
authors.initials: S
authors.lastname: Deeba
authors.forename: Omer
authors.initials: O
authors.lastname: Aziz
authors.forename: Parvinder S
authors.initials: PS
authors.lastname: Sains
authors.forename: Ara
authors.initials: A
authors.lastname: Darzi
mesh_terms: D001672:Biocompatible Materials; D003424:Crohn Disease / Q000150:complications; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D007413:Intestinal Mucosa / Q000637:transplantation; D007421:Intestine, Small / Q000637:transplantation; D012003:Rectal Fistula / Q000209:etiology / Q000628:therapy*; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives