The three musketeers of HSC development.
Hematopoietic stem cells (HSCs) are a key paradigm system for stem cell therapy applications. How these cells change from their multipotent to lineage-restricted cell states is still not fully understood. In this issue of Blood, McKinney-Freeman and colleagues show that members of a single transcription factor gene family are used in diverse and dynamic ways to implement this critical organogenesis program.
Ekker
Stephen
S
Mayo Clinic, USA.