Leptin, soluble leptin receptor, adiponectin and resistin in relation to OGTT in overweight/obese postmenopausal women.
OBJECTIVE
In obese postmenopausal women with normal glucose metabolism (NGT) and impaired glucose tolerance (IGT) we assessed serum leptin, adiponectin, resistin, soluble leptin receptor (sOB-R) during oral glucose tolerance test (OGTT) in order to investigate their response to acute changes in glucose and insulin in the abnormal glucose metabolism, as it is early detected by IGT.


METHODS
Thirty in total, overweight/obese postmenopausal women, were included in the study: 15 with NGT and 15 with IGT as it was diagnosed by OGTT. Serum glucose and insulin levels were measured at 30 min intervals, leptin, sOB-R, adiponectin and resistin at 60 min intervals during the 120 min OGTT.


RESULTS
In fasting state, leptin, adiponectin, resistin and sOB-R levels did not differ between the two groups. In women with NGT, leptin was positively correlated with BMI, insulin and HOMA, and negatively correlated with QUICKI and with sOB-R; adiponectin was negatively correlated with insulin and HOMA and positively correlated with QUICKI. In women with IGT, resistin was positively correlated with BMI and waist circumference. In both groups, sOB-R was negatively correlated with insulin. During OGTT, in both groups, leptin concentration increased significantly and fasting glucose predicts significantly serum leptin change; there was no change in adiponectin, resistin and sOB-R concentrations.


CONCLUSIONS
In overweight/obese postmenopausal women fat distribution does not affect leptin and adiponectin production. Abnormal glucose metabolism is not accompanied by disturbance in adipokines production. Leptin secretion is acutely regulated by glucose levels in insulin presence.
Hroussalas
Garifallia
G
Department of Biological Chemistry and Clinical Biochemistry, Medical School, University of Athens, Athens-Goudi, Greece.
Kassi
Eva
E
Dalamaga
Maria
M
Delimaris
Ioannis
I
Zachari
Ariadni
A
Dionyssiou-Asteriou
Amalia
A
D052242:Adiponectin / Q000378:metabolism; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism*; D054411:Receptors, Leptin / Q000378:metabolism; D052243:Resistin / Q000378:metabolism
C499918:ADIPOQ protein, human; D052242:Adiponectin; C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin; D052243:Resistin; D005947:Glucose