Association between soy and green tea (Camellia sinensis) diminishes hypercholesterolemia and increases total plasma antioxidant potential in dyslipidemic subjects.
OBJECTIVE
To evaluate the hypolipemic and antioxidant effects of soy and green tea alone and/or in association in dyslipidemic subjects.


METHODS
One hundred dyslipidemic individuals were allocated into four groups. The soy group ingested 50 g of soy (kinako) daily, and the green tea group ingested 3 g of green tea in 500 mL of water per day. A third group ingested 50 g of soy and 3 g of green tea daily, and the control group had a hypocholesterolemic diet. Evaluations were performed at baseline and after 45 and 90 d. Plasma levels of total cholesterol, high-density lipoprotein, and triacylglycerols were evaluated by automated methods. Low-density lipoprotein (LDL) cholesterol was calculated using the Friedewald equation. LDL was isolated by ultracentrifugation. Total plasma antioxidant capacity and plasma levels of total lipid hydroperoxides and those linked to LDL were evaluated by chemiluminescence. The results were expressed as median values and their 25th to 75th percentiles, with a 5% level of significance.


RESULTS
No significant difference occurred in LDL, high-density lipoprotein cholesterol, and triacylglycerol levels across groups. However, a statistically significant difference in total cholesterol occurred within the soy/green tea group 45 and 90 d after intervention. No statistically significant difference occurred in plasma levels of lipid hydroperoxides or those linked to LDL in any of the groups studied. All the groups that used soy and/or green tea presented increased total plasma antioxidant potential.


CONCLUSIONS
Soy and green tea, alone or in combination, increased the total antioxidant potential of hypercholesterolemic patients, whereas only the combination decreased total cholesterol levels.
Bertipaglia de Santana
Márcia
M
Hospital Universitário de Londrina, Brazil.
Mandarino
Marcos Gontijo
MG
Cardoso
Jefferson Rosa
JR
Dichi
Isaías
I
Dichi
Jane Bandeira
JB
Camargo
Alissana Ester Iakmiu
AE
Fabris
Bruno Alberto
BA
Rodrigues
Ricardo José
RJ
Fatel
Elis Carolina Souza
EC
Nixdorf
Suzana Lucy
SL
Simão
Andréa Name Colado
AN
Cecchini
Rubens
R
Barbosa
Décio Sabbatini
DS
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D028241:Camellia sinensis / Q000737:chemistry*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004357:Drug Synergism; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D000975:Antioxidants; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts; D014280:Triglycerides