TAPPred prediction of TAP-binding peptides in antigens.
The transporter associated with antigen processing (TAP) plays a crucial role in the transport of the peptide fragments of the proteolysed antigenic or self-altered proteins to the endoplasmic reticulum where the association between these peptides and the major histocompatibility complex (MHC) class I molecules takes place. Therefore, prediction of TAP-binding peptides is highly helpful in identifying the MHC class I-restricted T-cell epitopes and hence in the subunit vaccine designing. In this chapter, we describe a support vector machine (SVM)-based method TAPPred that allows users to predict TAP-binding affinity of peptides over web. The server allows user to predict TAP binders using a simple SVM model or cascade SVM model. The server also allows user to customize the display/output. It is freely available for academicians and noncommercial organization at the address http://www.imtech.res.in/raghava/tappred.
Bhasin
Manoj
M
Institute of Microbial Technology, Chandigarh, India.
Lata
Sneh
S
Raghava
G P S
GP
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D017951:Antigen Presentation; D001185:Artificial Intelligence; D019295:Computational Biology; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D007125:Immunogenetics; D020407:Internet; D010455:Peptides / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D011485:Protein Binding; D022223:Vaccines, Subunit / Q000737:chemistry
D018528:ATP-Binding Cassette Transporters; D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; D010455:Peptides; D022223:Vaccines, Subunit; C477327:transporter associated with antigen processing (TAP)