title: Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici.
abstract: Pestaloficiols A-E (1-5), five new cyclopropane derivatives, have been isolated from cultures of the plant endophyte Pestalotiopsis fici. The structures of these compounds were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 4 displayed inhibitory effects on HIV-1 replication in C8166 cells.
authors.affiliation: Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Renrong
authors.initials: R
authors.lastname: Tian
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Xulin
authors.initials: X
authors.lastname: Chen
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000494:pharmacology*; D010944:Plants / Q000382:microbiology*; D020033:Protein Isoforms / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D003521:Cyclopropanes; D006575:Heterocyclic Compounds, 3-Ring; D020033:Protein Isoforms; D012717:Sesquiterpenes; C529353:pestalotheol C; C430595:pestalotiopsin A; C030797:cyclopropane