title: [Investigation of the prevalence of drug-induced gingival overgrowth in renal transplant recipients medicated with cyclosporine A or tacrolimus].
abstract: OBJECTIVE
  To investigate the prevalence of gingival overgrowth(GO) in a group of renal transplant recipients medicated with cyclosporine A(CsA) in comparison to those medicated with tacrolimus(Tcr).
  
  
  METHODS
  107 renal transplant recipients ( 85 CsA and 25 Tcr) were recruited into this study. Demographic, pharmacologic and periodontal data was recorded. The prevalence and severity of GO were compared between the two groups. The data was analyzed by SPSS13.0 software package for independent sample t test, chi(2) test, Mann-Whitney U test and stepwise regression analysis.
  
  
  RESULTS
  The prevalence of GO in the CsA group(49%)was significantly higher than that in the Tcr group(16%)(P<0.05). The CsA group showed a higher mean GO score (30.3+/-15.5) compared with the Tcr group(17.5+/-9.6) (P<0.001).In addition, the patients with GO presented a significantly higher plaque index and papilla bleeding index than those without GO in two groups(P<0.05).
  
  
  CONCLUSIONS
  The prevalence of GO is higher in renal transplant recipients taking CsA compared to Tcr. Plaque-induced gingival inflammation has a close relation with the severity of GO.
authors.affiliation: Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Gong
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Zhang-Yu
authors.initials: ZY
authors.lastname: Gu
mesh_terms: D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D003773:Dental Plaque; D003774:Dental Plaque Index; D019214:Gingival Overgrowth / Q000139:chemically induced*; D005891:Gingivitis; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use; D066027:Transplant Recipients
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus