title: Preventing household transmission of Shiga toxin-producing Escherichia coli O157 infection: promptly separating siblings might be the key.
abstract: BACKGROUND
  Preventing household transmission of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection is important because of the ease of interpersonal transmission and the potential disease severity.
  
  
  METHODS
  We conducted a retrospective cohort study of households associated with an outbreak of STEC O157 infection in South Wales, United Kingdom, in autumn 2005. We investigated whether characteristics of the primary case patient or the household were predictors for secondary household transmission of STEC O157 infection. Furthermore, we estimated the proportion of cases that might be prevented by isolation (e.g., hospitalization) of the primary case patient immediately after the microbiological diagnosis and the number of patients with STEC O157 who would need to be isolated to prevent 1 case of hemolytic uremic syndrome. Based on dates of symptom onset, case patients in households were classified as having primary, coprimary, or secondary infection. Secondary cases were considered to be preventable if the secondary case patient's symptoms started >1 incubation period (4 days) after the date of microbiological diagnosis of the primary case.
  
  
  RESULTS
  Eighty-nine (91%) of 98 eligible households were enrolled. Among 20 households (22%), 25 secondary cases were ascertained. Thirteen secondary cases (56%) occurred in siblings of the primary case patients; hemolytic uremic syndrome developed in 4 of these siblings. Presence of a sibling (risk ratio, 3.8; 95% confidence interval, 0.99-14.6) and young age (<5 years) of the primary case patient (risk ratio, 2.03; 95% confidence interval, 0.99-41.6) were independent predictors for households in which secondary cases occurred. Of the 15 secondary cases for which complete information was available, 7 (46%) might have been prevented. When restricting isolation to primary case patients who were aged <10 years and who had a sibling, we estimated the number of patients who would need to be isolated to prevent 1 case of hemolytic uremic syndrome to be 47 patients (95% confidence interval, 16-78 patients).
  
  
  CONCLUSIONS
  Promptly separating pediatric patients with STEC O157 infection from their young siblings should be considered.
authors.affiliation: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, United Kingdom. werberd@rki.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Werber
authors.forename: Brendan W
authors.initials: BW
authors.lastname: Mason
authors.forename: Meirion R
authors.initials: MR
authors.lastname: Evans
authors.forename: Roland L
authors.initials: RL
authors.lastname: Salmon
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003140:Communicable Disease Control / Q000379:methods; D004927:Escherichia coli Infections / Q000517:prevention & control* / Q000635:transmission; D019453:Escherichia coli O157 / Q000302:isolation & purification*; D006801:Humans; D010356:Patient Isolation; D012189:Retrospective Studies; D054323:Shiga-Toxigenic Escherichia coli / Q000302:isolation & purification*; D035781:Siblings; D014852:Wales