Breastfeeding and child cognitive development: new evidence from a large randomized trial.
BACKGROUND
The evidence that breastfeeding improves cognitive development is based almost entirely on observational studies and is thus prone to confounding by subtle behavioral differences in the breastfeeding mother's behavior or her interaction with the infant.


OBJECTIVE
To assess whether prolonged and exclusive breastfeeding improves children's cognitive ability at age 6.5 years.


METHODS
Cluster-randomized trial, with enrollment from June 17, 1996, to December 31, 1997, and follow-up from December 21, 2002, to April 27, 2005.


METHODS
Thirty-one Belarussian maternity hospitals and their affiliated polyclinics.


METHODS
A total of 17,046 healthy breastfeeding infants were enrolled, of whom 13,889 (81.5%) were followed up at age 6.5 years.


METHODS
Breastfeeding promotion intervention modeled on the Baby-Friendly Hospital Initiative by the World Health Organization and UNICEF.


METHODS
Subtest and IQ scores on the Wechsler Abbreviated Scales of Intelligence, and teacher evaluations of academic performance in reading, writing, mathematics, and other subjects.


RESULTS
The experimental intervention led to a large increase in exclusive breastfeeding at age 3 months (43.3% for the experimental group vs 6.4% for the control group; P < .001) and a significantly higher prevalence of any breastfeeding at all ages up to and including 12 months. The experimental group had higher means on all of the Wechsler Abbreviated Scales of Intelligence measures, with cluster-adjusted mean differences (95% confidence intervals) of +7.5 (+0.8 to +14.3) for verbal IQ, +2.9 (-3.3 to +9.1) for performance IQ, and +5.9 (-1.0 to +12.8) for full-scale IQ. Teachers' academic ratings were significantly higher in the experimental group for both reading and writing.


CONCLUSIONS
These results, based on the largest randomized trial ever conducted in the area of human lactation, provide strong evidence that prolonged and exclusive breastfeeding improves children's cognitive development.


BACKGROUND
isrctn.org Identifier: ISRCTN37687716.
Kramer
Michael S
MS
Department of Pediatrics, McGill University, Montreal, Quebec, Canada. michael.kramer@mcgill.ca
Aboud
Frances
F
Mironova
Elena
E
Vanilovich
Irina
I
Platt
Robert W
RW
Matush
Lidia
L
Igumnov
Sergei
S
Fombonne
Eric
E
Bogdanovich
Natalia
N
Ducruet
Thierry
T
Collet
Jean-Paul
JP
Chalmers
Beverley
B
Hodnett
Ellen
E
Davidovsky
Sergei
S
Skugarevsky
Oleg
O
Trofimovich
Oleg
O
Kozlova
Ludmila
L
Shapiro
Stanley
S
D000367:Age Factors; D001942:Breast Feeding / Q000706:statistics & numerical data*; D002648:Child; D002657:Child Development / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D015995:Prevalence