[Pharmacological review of alcoholic dependence treatment].
The aim of the present pharmacological update is to revise the problem of alcohol dependence. Starting from the biological bases and the impact of alcohol on the neurobiological and neurotransmission systems, a revision of the main pharmacological tools for alcohol dependence treatment will be done. Disulfiram, naltrexone, acamprosate, all of them approved by the FDA (Food and Drug Administration), have shown mechanisms of action, efficacy, tolerance and adherence dissimilar. We will also refer to topiramate, which is being studied for this indication.
Oural
Leandro
L
Hospital Alvarez.
Paris
María V
MV
Sullivan
Oriana
O
Polach
Martina
M
Pavlovsky
Federico
F
Capece
José
J
D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000009:adverse effects / Q000627:therapeutic use*; D000437:Alcoholism / Q000534:rehabilitation*; D004221:Disulfiram / Q000009:adverse effects / Q000627:therapeutic use*; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D009271:Naltrexone / Q000009:adverse effects / Q000627:therapeutic use*; D013654:Taurine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077236:Topiramate
D000427:Alcohol Deterrents; D000077236:Topiramate; D013654:Taurine; D005632:Fructose; D009271:Naltrexone; D000077443:Acamprosate; D004221:Disulfiram