title: Histone modifications: cycling with chromosomal replication.
abstract: Histone modifications tend to be lost during chromosome duplication. Several recent studies suggest that the RNA interference pathway becomes active during the weakened transcriptional repression occurring at centromeres in S phase, resulting in the re-establishment of histone modifications that direct the formation of heterochromatin.
authors.affiliation: Department of Biology, University of Copenhagen, BioCenter, Copenhagen N, Denmark. gen@bio.ku.dk
authors.forename: Geneviève
authors.initials: G
authors.lastname: Thon
mesh_terms: D004261:DNA Replication / Q000502:physiology*; D006570:Heterochromatin / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D034622:RNA Interference / Q000502:physiology*; D016196:S Phase / Q000502:physiology*; D012568:Schizosaccharomyces
chemical_list: D006570:Heterochromatin; D006657:Histones