The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone.
The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine-turned implants (turned implants), (2) machine-turned and aluminum oxide-blasted implants (blasted implants), and (3) implants that were machine-turned, aluminum oxide-blasted, and processed with the micro-arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; p = 0.69) or summit density (Sds; p = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (p = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (p = 0.0001, p = 0.0001) and blasted (p = 0.0001, p = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (p = 0.02) but not at 3 weeks (p = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul.
Sul
Young-Taeg
YT
Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden. young-taeg.sul@biomaterials.gu.se
Kang
Byung-Soo
BS
Johansson
Carina
C
Um
Heung-Sik
HS
Park
Chan-Jin
CJ
Albrektsson
Tomas
T
D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D002645:Chickens; D020007:Implants, Experimental; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011817:Rabbits; D013057:Spectrum Analysis; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D019415:Torque
D014025:Titanium