HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions.
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. Although HDAC6 enzymatic activity seems to be required for the regulation of cell morphology, the role of HDAC6 in lymphocyte chemotaxis is independent of its tubulin deacetylase activity. The diverse functions of HDAC6 suggest that it is a potential therapeutic target for the treatment of a range of diseases. This review examines the biological actions of HDAC6, focusing on its deacetylase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.
Valenzuela-Fernández
Agustín
A
Departamento de Medicina Física y Farmacología, Facultad de Medicina and Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Tenerife, Spain.
Cabrero
J Román
JR
Serrador
Juan M
JM
Sánchez-Madrid
Francisco
F
D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D051356:Cortactin / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D005786:Gene Expression Regulation; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D007107:Immune System; D008954:Models, Biological; D009362:Neoplasm Metastasis; D011489:Protein Denaturation; D017510:Protein Folding; D014404:Tubulin / Q000737:chemistry
D051356:Cortactin; D018841:HSP90 Heat-Shock Proteins; D014404:Tubulin; C433811:HDAC6 protein, human; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases