title: Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes.
abstract: The level of natural apoptosis in rat thymus on day 18 of embryo development attained 25%, while at subsequent terms it was about 5%. In the spleen, this parameter gradually decreased from 15 to 37% starting from day 18 of embryo development to postnatal day 30. Tactivin prevented the development of dexamethasone-induced apoptosis in thymocytes of 30-day-old rats, but had no effect on spontaneous apoptosis. Tactivin can be used as a modulator of apoptotic processes.
authors.affiliation: N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Science.
authors.forename: V Y
authors.initials: VY
authors.lastname: Arion
authors.forename: V I
authors.initials: VI
authors.lastname: Mel'nikova
authors.forename: M A
authors.initials: MA
authors.lastname: Afanas'eva
authors.forename: S N
authors.initials: SN
authors.lastname: Moskvina
authors.forename: L A
authors.initials: LA
authors.lastname: Zakharova
mesh_terms: D000276:Adjuvants, Immunologic / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D003907:Dexamethasone / Q000633:toxicity*; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013949:Thymus Extracts / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D003907:Dexamethasone; C036191:T-activin