Acute renal failure secondary to chronic lymphocytic leukemia: a case report.
Acute renal insufficiency associated with chronic lymphocytic leukemia (CLL) has a variety of causes. An extremely rare cause of renal dysfunction is dense leukemic infiltrate in the renal interstitium. This report describes a patient with CLL who developed acute renal failure secondary to leukemic infiltration and who had a partial response to chemotherapy. This diagnosis should always be considered when a patient with CLL, regardless of the clinical stage, presents with renal insufficiency because it appears to respond reasonably well to a variety of therapies. The finding of enlarged kidneys on renal ultrasound is suggestive of infiltrative disease, but is not always present. Proteinuria is generally mild. The literature is reviewed.
Rifkin
Stephen I
SI
Division of Nephrology, University of South Florida College of Medicine, Tampa, Florida, USA. srifkin@health.usf.edu
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged