title: The effect of achiral calixarenes on chiral separation of propranolol-HCl and brompheniramine maleate in capillary electrophoresis using cyclodextrin as chiral selector.
abstract: In this study we have examined the effect of achiral water soluble p-sulfonatocalixarenes (SCX[n]) on chiral separation propranolol-HCl and brompheniramine maleate. Several cyclodextrins (CDs) and cyclodextrin derivatives were examined as chiral selectors applying complete filling technique (CFT) accompanied with the partial filling technique PFT of (SCX[n]) as achiral modifier. Only with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) chiral separation could be achieved. The effect of the organic modifier on these chiral separations was examined. The results indicate that at pH 4.65, the use of HP-beta-CD (CFT) alone could not initiate chiral separations of both analytes and these chiral separations could be induced using HP-beta-CD (CFT) followed by SCX[n]/HP-beta-CD (PFT).
authors.affiliation: Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hashem
authors.forename: M
authors.initials: M
authors.lastname: Kinzig
authors.forename: T
authors.initials: T
authors.lastname: Jira
mesh_terms: D000318:Adrenergic beta-Agonists / Q000302:isolation & purification*; D001977:Brompheniramine / Q000302:isolation & purification*; D047250:Calixarenes / Q000737:chemistry*; D053801:Capillary Electrochromatography; D003505:Cyclodextrins / Q000737:chemistry*; D006634:Histamine H1 Antagonists / Q000302:isolation & purification*; D007202:Indicators and Reagents; D011433:Propranolol / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000318:Adrenergic beta-Agonists; D003505:Cyclodextrins; D006634:Histamine H1 Antagonists; D007202:Indicators and Reagents; D047250:Calixarenes; D011433:Propranolol; D001977:Brompheniramine