Purinergic regulation of neutrophil chemotaxis.
Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected and inflamed sites. However, excessive influx of PMN damages host tissues. Better knowledge of the mechanisms that control PMN chemotaxis may lead to improved treatments of inflammatory diseases. Recent findings suggest that ATP and adenosine are involved in PMN chemotaxis. Therefore, these purinergic signaling processes may be suitable targets for novel therapeutic approaches to ameliorate host tissue damage.
Junger
W G
WG
Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, East Stoneman 8M 10C, Boston, Massachusetts 02215, USA. wjunger@bidmc.harvard.edu
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002634:Chemotaxis, Leukocyte; D006801:Humans; D008954:Models, Biological; D009504:Neutrophils / Q000166:cytology*; D011687:Purines / Q000378:metabolism*; D011983:Receptors, Purinergic / Q000378:metabolism
D011687:Purines; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate