title: Efficacy of Nyoshinsan/TJ-67, a traditional herbal medicine, for menopausal symtoms following surgery and adjuvant chemotherapy for premenopausal breast cancer.
abstract: We report a 39-year-old woman with premenopausal breast cancer who developed estrogen-deficiency symptoms associated with chemotherapy-related amenorrhea, and was successfully treated with Nyoshinsan/TJ-67, a Japanese traditional herbal medicine (Kampo). Six other breast cancer survivors with menopausal symptoms were also treated with Nyoshinsan/TJ-67, and five of the six patients showed noticeable improvement without adverse effects. Managing estrogen-deficiency symptoms in breast cancer survivors is still problematic, and Nyoshinsan/TJ-67 may be a useful and safe agent for such symptoms in these patients.
authors.affiliation: Department of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. tkogure@showa.gunma-u.ac.jp
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kogure
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ito
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ito
authors.forename: Yuko
authors.initials: Y
authors.lastname: Oku
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tatsumi
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D029001:Herbal Medicine; D006801:Humans; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D017697:Premenopause
chemical_list: D000970:Antineoplastic Agents; D004967:Estrogens; D010936:Plant Extracts; C532348:nyoshinsan