title: Trigeminal autonomic cephalalgias: diagnostic and therapeutic developments.
abstract: OBJECTIVE
  The review was designed to summarize recent research relevant to the trigeminal autonomic cephalalgias, which include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing/cranial autonomic features (SUNCT/SUNA). Hemicrania continua is included for completeness.
  
  
  RESULTS
  Cluster headache has the longest attack duration and relatively low attack frequency. Paroxysmal hemicrania has intermediate duration and intermediate attack frequency. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing have the shortest attack duration and the highest attack frequency. Hemicrania continua has a continuous pain with exacerbations that can include cranial autonomic symptoms as part of the phenotype. The importance of diagnosing these syndromes resides in their excellent but highly selective response to treatment.
  
  
  CONCLUSIONS
  Considerable advances have been made in the diagnostic and therapeutic approaches to trigeminal autonomic cephalalgias and these are important for neurologists to consider.
authors.affiliation: Headache Group, Department of Neurology, University of California, San Francisco, San Francisco California 94143-0114, USA. peter.goadsby@ucsf.edu
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Goadsby
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Cittadini
authors.forename: Brian
authors.initials: B
authors.lastname: Burns
authors.forename: Anna S
authors.initials: AS
authors.lastname: Cohen
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D010900:Pituitary Diseases / Q000175:diagnosis; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D051303:Trigeminal Autonomic Cephalalgias / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D014363:Tryptamines / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D017366:Serotonin Receptor Agonists; D014363:Tryptamines