title: Proliferative effects of insulin analogues on mammary epithelial cells.
abstract: Structural modification of insulin results in the generation of insulin analogues that show altered binding affinities to the insulin receptor and/or IGF-I receptor. As a consequence these insulin analogues may have increased mitogenic potency. Nine benign or malignant human mammary epithelial cells, which show different insulin receptor and IGF-I receptor expression patterns, were studied regarding mitogenicity of insulin and insulin analogues. Only insulin glargine showed a significantly higher proliferative effect on MCF-7 breast cancer cells compared to regular insulin among a panel of short- or long-acting insulin analogues, that are in clinical use.
authors.affiliation: Hormones and Signal Transduction, German Cancer Research Centre, Heidelberg, Germany. d.mayer@dkfz.de
authors.forename: Doris
authors.initials: D
authors.lastname: Mayer
authors.forename: Ashish
authors.initials: A
authors.lastname: Shukla
authors.forename: Harald
authors.initials: H
authors.lastname: Enzmann
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology* / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000187:drug effects; D042361:Mammary Glands, Human / Q000166:cytology* / Q000187:drug effects; D017526:Receptor, IGF Type 1 / Q000378:metabolism
chemical_list: D007328:Insulin; D017526:Receptor, IGF Type 1