Synthesis of multimeric MR contrast agents for cellular imaging.
We have prepared a series of molecular multimeric MR contrast agents for cell labeling that are easy to synthesize, relatively low molecular weight, and biocompatible. The relaxivities of the agents range from 17 to 85 mM(-1) s(-1). Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity.
Song
Ying
Y
Departments of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Kohlmeir
Ellen K
EK
Meade
Thomas J
TJ
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis* / Q000494:pharmacology; D005682:Gadolinium / Q000737:chemistry* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D041681:NIH 3T3 Cells; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D001672:Biocompatible Materials; D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium