title: [Prognostic value of first fasting glucose measurement compared with admission glucose level in patients with acute coronary syndrome].
abstract: OBJECTIVE
  The admission plasma glucose (APG) level is a recognized prognostic factor in patients with acute coronary syndrome (ACS). However, little is known about the prognostic value of the first fasting plasma glucose (FPG) measurement. The aim of this study was to determine the prognostic value of the first FPG measurement relative to that of the APG level in patients with ACS.
  
  
  METHODS
  The study involved 547 consecutive patients who were admitted to our center with a diagnosis of ACS in 2006. Patients were divided into three groups according to their first FPG or APG level (i.e., <126 mg/dL, 126-200 mg/dL, or >200 mg/dL). The primary endpoint was the combined outcome of death or reinfarction during hospitalization.
  
  
  RESULTS
  The primary endpoint was observed in 46 patients, 25 of whom died. Patients in this group were older, were more often diabetics or smokers, more often had had a prior myocardial infarction, were in a higher admission Killip class, showed more than one vessel disease on catheterization, had a lower left ventricular ejection fraction, and had higher admission creatinine, APG, and first FPG levels. Multivariate analysis, adjusted for previously identified factors, revealed that the first FPG level was an independent risk factor for death or reinfarction (126-200 mg/dL, odds ratio [OR]=5.26; 95% confidence interval [CI], 1.09-25.45; >200 mg/dL, OR=6.66; 95% CI, 2.05-21.63), but that the APG level was not (126-200 mg/dL, OR=0.84; 95% CI, 0.63-1.05; >200 mg/dL, OR=1.14; 95% CI, 0.29-4.51).
  
  
  CONCLUSIONS
  The first FPG level was found to be a better predictor of an adverse outcome (i.e., death or reinfarction) during hospitalization in ACS patients than the APG level.
authors.affiliation: Unidad Coronaria, Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid. España. david_vivas_balcones@hotmail.com
authors.forename: David
authors.initials: D
authors.lastname: Vivas
authors.forename: Juan C
authors.initials: JC
authors.lastname: García-Rubira
authors.forename: Juan J
authors.initials: JJ
authors.lastname: González-Ferrer
authors.forename: Iván
authors.initials: I
authors.lastname: Núñez-Gil
authors.forename: Náyade
authors.initials: N
authors.lastname: del Prado
authors.forename: Antonio
authors.initials: A
authors.lastname: Fernández-Ortiz
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D015331:Cohort Studies; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D001786:Blood Glucose