[Psoriasis, metabolic syndrome and its components].
The psoriasis is a chronic dermatosis which is characterized by strong inflammation. Recent studies showed that the chronic inflammation plays an important part in the pathogenesis of many metabolic and vascular diseases. Moreover, the diseases mediated by lymphocytes TH1 were related to the myocardial infarction. Epidemiologic investigations showed that psoriasis is associated at the increased risk of Comorbidities and mortality per comparison to the general population. Thus, the psoriatic patients have a high prevalence of metabolic pathologies such as the diabetes, hypertension, obesity and hyperlipidemy. These concomitant affections can complicate the treatment of psoriasis. It is important that the dermatologist systematically seeks these concomitant pathologies among psoriatic patients. These data also suggest that the treatments of these patients improve not only the skin lesions, but also control the inflammation associated with the psoriasis.
Ortonne
J-P
JP
CHU de Nice, Service de Dermatologie, Hôpital 1'Archet 2, Avenue St Antoine de Ginestière, 06100 Nice, France. ortonne@unice.fr
D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007249:Inflammation / Q000150:complications; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009203:Myocardial Infarction / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D011565:Psoriasis / Q000150:complications* / Q000503:physiopathology*