Phenolic glycosides from Lindera fruticosa root and their inhibitory activity on osteoclast differentiation.
Two new compounds were found in the phenolic glycosides isolated from the roots of Lindera fruticosa: 5-O-[beta-D-apiofuranosyl-(1''-->2')-O-beta-D-xylopyranosyl]gentisic acid-7,5''-ester (3), named linderofruticoside A; and 5-O-[beta-D-apiofuranosyl-(1''-->3')-O-beta-D-xylopyranosyl]gentisic acid methyl ester (4), linderofruticoside B. Two previously known phenolic glycosides were also identified: beta-D-(3,4-disinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside (1) and beta-D-(3-sinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside (2). Compounds 1 and 2 inhibited osteoclast differentiation in a dose-dependent manner at concentrations higher than 1.04 microM and 0.132 microM, respectively.
Song
Myoung-Chong
MC
Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon, South Korea.
Nigussie
Fikru
F
Yang
Hye-Joung
HJ
Kim
Hong-Hee
HH
Kim
Ji-Young
JY
Chung
Dae-Kyun
DK
Baek
Nam-In
NI
D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002454:Cell Differentiation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006868:Hydrolysis; D027443:Lindera / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D013055:Spectrophotometry, Infrared
D006027:Glycosides; D010636:Phenols; C529691:linderofruticoside A; C529692:linderofruticoside B