Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.
Pharmacokinetics of an original compound GB-115 (N-phenylhexanoylglycyltryptophan) synthesized on the basis of the structure of endogenous tetrapeptide cholecystokinin-4 was studied by means of high-performance liquid chromatography. Pharmacokinetic parameters were calculated after intravenous and peroral administration of GB-115. Our results indicate that this dipeptide is resistant to peptidases. The absolute bioavailability of GB-115 is 4.65%.
Boyko
S S
SS
V. V. Zakusov Institute of Pharmacology, Russian Academy of Sciences, Moscow. sarpharm@mail.ru
Kolyvanov
G B
GB
Zherdev
V P
VP
Gudasheva
T A
TA
Kiryanova
E P
EP
Seredenin
S B
SB
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000008:administration & dosage / Q000235:genetics / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D014364:Tryptophan / Q000737:chemistry
D004151:Dipeptides; C520797:GB-115; D014364:Tryptophan