Lanthanide luminescent displacement assays: the sensing of phosphate anions using Eu(III)-cyclen-conjugated gold nanoparticles in aqueous solution.
1.Eu, a cyclen based Eu(III)-thiol conjugate, was incorporated onto the surface of water-soluble gold nanoparticles to give AuNP-1.Eu. The self-assembly between AuNP-1.Eu and the antenna 2 resulted in the formation of the highly luminescent lanthanide system, AuNP-1.Eu-2, at pH 7.4. The sensing of flavin monophosphate 3 is demonstrated, whereby 3 displaced the antenna 2 in AuNP-1.Eu-2, resulting in the formation of AuNP-1.Eu-3 and quenching of the Eu(III) emission.
Massue
Julien
J
School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
Quinn
Susan J
SJ
Gunnlaugsson
Thorfinnur
T
D000080027:Cyclams; D005063:Europium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008163:Luminescent Measurements; D053768:Metal Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010710:Phosphates / Q000032:analysis*; D012996:Solutions; D014867:Water / Q000737:chemistry
D000080027:Cyclams; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D010710:Phosphates; D012996:Solutions; D014867:Water; D005063:Europium; D006046:Gold; C038072:cyclen