title: Optimization of perfusion CT protocol for imaging of extracranial head and neck tumors.
abstract: The in vivo assessment of physiological processes associated with microcirculation in the head and neck tissue by means of perfusion computed tomography is widely used in the management of patients with head and neck tumors. However, there is no systematic consideration of the total acquisition duration and placement of the scans. A simulation study for optimizing perfusion studies of extracranial head and neck tumors, with considerations of reducing radiation dose while maintaining accuracy of the perfusion parameters, is demonstrated here. The suggested that dual-phase optimized protocols may provide reliable estimations of the permeability surface area product as well as blood flow and volume without additional radiation burden and serious patient discomfort. These optimized protocols can potentially be useful in the clinical setting of examining patients with extracranial head and neck tumors.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany. s.bisdas@med.uni-frankfurt.de
authors.forename: Sotirios
authors.initials: S
authors.lastname: Bisdas
authors.forename: Chuan Zhi
authors.initials: CZ
authors.lastname: Foo
authors.forename: Choon Hua
authors.initials: CH
authors.lastname: Thng
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: Tong San
authors.initials: TS
authors.lastname: Koh
mesh_terms: D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging*; D007700:Kinetics; D008954:Models, Biological; D009010:Monte Carlo Method; D011856:Radiographic Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media