title: The antimicrobial and antifungal efficacy of tetracycline-integrated gutta-percha.
abstract: The purpose of this study was in vitro evaluation of the antimicrobial and antifungal efficacy of commercially available gutta-percha containing tetracycline on some potential endodontic pathogens. The test microorganisms were Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Porphyromonas endodontalis, and Candida albicans . Tetracycline-integrated gutta-percha (TGP) cones, tetracycline disc, and conventional gutta-percha cones of the same size were placed on the inoculated plates. The plates were incubated at 37 degrees C aerobically or anaerobically. Growth inhibition zones on each plate were inspected at 24, 48, and 72 h. Tetracycline disc and TGP cones inhibited all the tested bacterial strains, however the greatest antimicrobial effect was seen on S. aureus. Tetracycline disc and TGP seemed less effective on E. faecalis and P. aeruginosa. However, all tested treatments were unable to affect C. albicans . Based on the results of this study, it seems that TGP offers an antimicrobial advantage over conventional gutta-percha.
authors.affiliation: Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey. bodrumlu@omu.edu.tr
authors.forename: Emre
authors.initials: E
authors.lastname: Bodrumlu
authors.forename: Tayfun
authors.initials: T
authors.lastname: Alaçam
authors.forename: Mustafa
authors.initials: M
authors.lastname: Semiz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D006171:Gutta-Percha / Q000737:chemistry / Q000494:pharmacology*; D045202:Porphyromonas endodontalis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012387:Root Canal Filling Materials / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012387:Root Canal Filling Materials; D006171:Gutta-Percha; D013752:Tetracycline