title: Study on the preparation of collagen-modified silk fibroin films and their properties.
abstract: Blended films were prepared from a silk fibroin (SF) solution by adding a small amount of type I collagen (<5%). The mechanical properties of the wet films modified by collagen were improved obviously. The elongation at break reached 42%, and the smaller contact angles revealed that modified films had better hydrophilicity. 1% heparin was also added to modify the SF films to further improve the in vitro antithrombogenecity. The internal structure of the modified SF films was investigated with scanning electron microscopy, x-ray diffraction and Fourier transform infrared attenuated total reflection spectroscopy. The result indicates that the addition of a small amount of collagen and heparin did not change their conformation.
authors.affiliation: Research Center of Material Science, Beijing Institute of Technology, Bejing 100081, People's Republic of China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Tang
authors.forename: Chuanbao
authors.initials: C
authors.lastname: Cao
authors.forename: Xilan
authors.initials: X
authors.lastname: Ma
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Hesun
authors.initials: H
authors.lastname: Zhu
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry*; D001777:Blood Coagulation / Q000187:drug effects*; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry*; D004548:Elasticity; D005349:Fibroins / Q000008:administration & dosage* / Q000737:chemistry*; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D047011:Silk / Q000008:administration & dosage* / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D047011:Silk; D006493:Heparin; D003094:Collagen; D005349:Fibroins