title: [Risk factors leading to failure in myringoplasty: a case-control study].
abstract: OBJECTIVE
  To determine the risk factors associated with myringoplasty failure among the study population, a case-control study was carried out in 2 tertiary hospital centers.
  
  
  METHODS
  Patients undergoing tympanic membrane perforation or atelectasis within 3 to 6 months following surgery were considered as cases, otherwise, they were considered to be controls. Patients having undergone any type of ossiculoplasty were excluded. Seventy cases and 210 controls were included, a sample size calculated for the following variables: inflammation at time of surgery, place and size of the tympanic membrane perforation, presence of tympanosclerosis, presence of cholesteatoma, and surgical technique. Odds ratio was calculated as main association measure, a stratified analysis was performed to rule out possible confusion factors.
  
  
  RESULTS
  No significant differences were found between the 2 groups respect to the variables for which the sample was calculated. Although in total group the addition of a modified radical mastoidectomy showed better operative results (95 % CI OR = 0.13-0.72; P=.002), in isolated tympanic membrane perforation this association it was loosed (95 % CI OR = 0.06-7.44; P=.81).
  
  
  CONCLUSIONS
  Results in this study suggest that the variables for which the sample size was calculated are not associated with myringoplasty failure in this population.
authors.affiliation: Servicio integrado de Otorrinolaringología, Hospital Militar Central-Hospital Universitario Clínica San Rafael, Universidad Militar Nueva Granada, Bogotá, Colombia. leoorl@gmail.com
authors.forename: Leonardo E
authors.initials: LE
authors.lastname: Ordóñez-Ordóñez
authors.forename: Esther S
authors.initials: ES
authors.lastname: Angulo-Martínez
authors.forename: José A
authors.initials: JA
authors.lastname: Prieto-Rivera
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Almario-Chaparro
authors.forename: José E
authors.initials: JE
authors.lastname: Guzmán-Durán
authors.forename: José G
authors.initials: JG
authors.lastname: Lora-Falquez
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009225:Myringoplasty / Q000379:methods*; D012307:Risk Factors; D017211:Treatment Failure; D018058:Tympanic Membrane Perforation / Q000601:surgery*