title: Comparative analysis of homocysteine concentrations in patients with retinal vein occlusion versus thrombotic and atherosclerotic disorders.
abstract: The objectives of the present study were to determine the concentrations of plasma homocysteine in a large (n = 562) cohort of patients with retinal vein occlusion (RVO) and to compare them with the values observed in other vascular thrombotic and atherosclerotic conditions. Results were compared with those observed in patients with deep vein thrombosis (n = 1700), pulmonary embolism (n = 542), transient ischemic attack (n = 1301), cerebrovascular accident (n = 1299), myocardial infarction (n = 3087), as well as peripheral artery occlusive disease (n = 1946). No differences were found between the age-adjusted estimated marginal mean +/- SE for homocysteine concentrations in individuals with RVO and in those who had other atherosclerotic and atherothrombotic diseases The respective concentrations for RVO, deep vein thrombosis, pulmonary embolism, transient ischemic attack, cerebrovascular accident, myocardial infarction, and peripheral artery occlusive disease were 13.8 +/- 0.4, 14.7 +/- 0.3, 14.3 +/- 0.5, 14.2 +/- 0.3,14.6 +/- 0.3, 13.8 +/- 0.2, 14.4 +/- 0.2 pmol/l for men and 11.4 +/- 0.4, 10.7 +/- 0.2, 10.8 +/- 0.3, 10.8 +/- 0.2, 11.8 +/- 0.2, 11.2 +/- 0.2 pmol/l for women. In conclusion, the concentrations of homocysteine observed in patients with RVO are similar to those detected in other thrombotic and atherosclerotic vascular disorders. In view of the fact that this is a common disorder of the elderly, increased homocysteine concentrations often reported in patients with RVO could reflect the underlying atherothrombotic condition and might not necessarily be specifically related to the RVO per se. This information is relevant in researching the potential etiopathologic role, if any, of increased homocysteine concentrations in RVO.
authors.affiliation: Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Israel. kesler@netvision.net.il
authors.forename: Anat
authors.initials: A
authors.lastname: Kesler
authors.forename: Varda
authors.initials: V
authors.lastname: Shalev
authors.forename: Ori
authors.initials: O
authors.lastname: Rogowski
authors.forename: Orit
authors.initials: O
authors.lastname: Shimron
authors.forename: Bracha
authors.initials: B
authors.lastname: Shainberg
authors.forename: Ben-Ami
authors.initials: BA
authors.lastname: Sela
authors.forename: Itzhak
authors.initials: I
authors.lastname: Shapira
authors.forename: Ophira
authors.initials: O
authors.lastname: Salomon
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D012170:Retinal Vein Occlusion / Q000097:blood*; D013927:Thrombosis / Q000097:blood*
chemical_list: D006710:Homocysteine