A cyclotrimerization route to cannabinoids.
Three members of the cannabinoid class, cannabinol, cannabinol methyl ether, and cannabinodiol, were synthesized using a microwave-mediated [2 + 2 + 2] cyclotrimerization reaction as the key step. This approach provides a high level of synthetic flexibility allowing for the facile synthesis of cannabinoid analogues.
Teske
Jesse A
JA
North Carolina State University, Department of Chemistry, Raleigh, North Carolina 27695-8204, USA.
Deiters
Alexander
A
D000480:Alkynes / Q000737:chemistry; D002186:Cannabinoids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D009570:Nitriles / Q000737:chemistry
D000480:Alkynes; D002186:Cannabinoids; D009570:Nitriles