Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
It has been reported that antibodies (Abs) against heterogeneous nuclear ribonucleoproteins (hnRNPs) are associated with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). However, these studies were done under nonmasked conditions. In order to determine whether Abs against hnRNPs associate with HAM/TSP and MS, the authors assayed Abs against two major hnRNPs, hnRNP A1 and A2/B1, in 105 cerebrospinal fluid (CSF) samples under fully masked conditions. Samples included 40 cases of HAM/TSP, 28 of MS, and 37 of other neurological diseases. Anti-hnRNP A1 Abs, and especially anti-hnRNP A2/B1 Abs, were found significantly more often in the CSF of MS patients than in other groups. However, there was no difference in the incidence of anti-hnRNP A1 Abs between HAM/TSP and other disease groups.
Yukitake
Motohiro
M
Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. yukitake@cc.saga-u.ac.jp
Sueoka
Eisaburo
E
Sueoka-Aragane
Naoko
N
Sato
Akemi
A
Ohashi
Hiromi
H
Yakushiji
Yusuke
Y
Saito
Mineki
M
Osame
Mitsuhiro
M
Izumo
Shuji
S
Kuroda
Yasuo
Y
D000917:Antibody Formation; D001323:Autoantibodies / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D001921:Brain / Q000378:metabolism; D015481:HTLV-I Antibodies; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000134:cerebrospinal fluid* / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology*; D015493:Paraparesis, Tropical Spastic / Q000276:immunology; D011897:Random Allocation
D001323:Autoantibodies; D015481:HTLV-I Antibodies; D034441:Heterogeneous-Nuclear Ribonucleoproteins