When proton pumps go sour: Urinary acidification and kidney stones.
H(+)-ATPases mediate urinary acidification along the collecting duct, and mutations in their B1 and a4 subunits result in distal renal tubular acidosis. The pathomechanisms by which these mutations affect pump activity are only poorly understood. Common polymorphisms may impair pump activity and may link the pump to a higher risk for alkaline urine and the development of kidney stones.
Wagner
C A
CA
Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Wagnerca@access.uzh.ch
D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000209:etiology*; D009154:Mutation; D017494:Proton Pumps / Q000378:metabolism*; D006180:Proton-Translocating ATPases / Q000235:genetics*; D014556:Urine
D017494:Proton Pumps; D006180:Proton-Translocating ATPases