[Adipose tissue-derived stem cells: hepatic plasticity].
Currently, the only effective treatment for end-stage liver disease is liver transplantation. The number of patients on the waiting list increases considerably each year, giving rise to a wide imbalance between supply and demand for healthy livers. Knowledge of stem cells and their possible use have awakened great interest in the field of hepatology, these cells being one of the most promising short-term alternatives. Hepatic stem cell therapy consists of the implantation of healthy cells capable of performing the functions that damaged cells are unable to carry out. Recent observations indicate that several stem cells can differentiate into distinct cell lineages. Hepatic differentiation of adult stem cells from several origins has yielded highly promising results. Adipose tissue in adults contains a reservoir of stem cells that can be induced and differentiated into different types of cells, showing a high degree of plasticity. Because of its abundance and easy access, adipose tissue is a promising source of adult stem cells for hepatic stem cell therapy. The present article reviews the progress made in the differentiation of adult stem cells from adipose tissue into cells with hepatic phenotype. We also discuss the potential application of this technique as a therapy for temporary metabolic support in patients with end-stage liver failure awaiting whole organ transplantation, as a method to support liver function and facilitate regeneration of the native liver in cases of fulminant hepatic failure, and as a treatment in patients with genetic metabolic defects in vital liver functions.
Bonora-Centelles
Ana
A
Unidad de Hepatología Experimental, Centro de Investigación, Hospital Universitario La Fe, Valencia, España.
Castell
José Vicente
JV
Gómez-Lechón
María José
MJ
D000273:Adipose Tissue / Q000166:cytology*; D002454:Cell Differentiation; D005544:Forecasting; D022781:Hepatocytes; D006801:Humans; D017093:Liver Failure / Q000601:surgery*; D059630:Mesenchymal Stem Cells; D010641:Phenotype; D033581:Stem Cell Transplantation