title: Correlation between manual muscle strength and interleukin-6 (IL-6) plasma levels in elderly community-dwelling women.
abstract: Sarcopenia is a loss of muscle mass related to aging and leads to muscle performance decline. An increase in inflammatory mediator levels, especially of IL-6, has been associated to reduced muscle strength in the elderly. The aim of the present cross-sectional study was to correlate IL-6 plasma levels with manual muscle strength (MMS) in 63 community-dwelling elderly women. (71.2+/-7.4years). IL-6 was measured using enzyme-linked immunosorbent assay (ELISA) and MMS was measured using the JAMAR dynamometer. Pearson's test was used to explore the relationship between the outcomes at the significance level of alpha=0.05. IL-6 levels (2.56+/-3.44pg/ml) and MMS (22.86+/-4.62kgf) exhibited an inverse correlation (r=-0.2673 and p=0.0373). The increase in IL-6 plasma levels possibly contributed toward the reduction in manual muscle strength among the elderly women studied.
authors.affiliation: Departamento de Fisioterapia da Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais, UFMG, Av. Antônio Carlos, 6.627 Campus Pampulha, 31270-901 Belo Horizonte, MG, Brazil. leanismp.bh@terra.com.br
authors.forename: Leani Souza Máximo
authors.initials: LS
authors.lastname: Pereira
authors.forename: Fabrícia Mendes Silva
authors.initials: FM
authors.lastname: Narciso
authors.forename: Daniela Matos Garcia
authors.initials: DM
authors.lastname: Oliveira
authors.forename: Fernanda Matos
authors.initials: FM
authors.lastname: Coelho
authors.forename: Danielle da Glória de
authors.initials: Dda G
authors.lastname: Souza
authors.forename: Rosângela Corrêa
authors.initials: RC
authors.lastname: Dias
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001938:Brazil; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D053580:Muscle Strength / Q000502:physiology*
chemical_list: D015850:Interleukin-6