title: Topical therapy is first line treatment for chronic anal fissure because of the risk of incontinence with sphincterotomy.
authors.forename: David
authors.initials: D
authors.lastname: Lubowski
mesh_terms: D000287:Administration, Topical; D002908:Chronic Disease; D003672:Defecation / Q000187:drug effects; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005242:Fecal Incontinence / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage*; D011183:Postoperative Complications; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin