title: Discovery-based strategies for studying platelet function.
abstract: The platelet is an anucleate cell, complicating efforts to study platelet function by traditional genetic means. Discovery-based strategies have lead to the identification of pharmacological agents capable of targeting specific proteins critical for platelet activation. This review will address the evolution of discovery-based strategies to identify probes that are at once useful reagents for studying platelet activation and effective therapeutics.
authors.affiliation: Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. rflaumen@bidmc.harvard.edu
authors.forename: R
authors.initials: R
authors.lastname: Flaumenhaft
authors.forename: J R
authors.initials: JR
authors.lastname: Dilks
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D015335:Molecular Probes / Q000737:chemistry / Q000494:pharmacology; D015539:Platelet Activation / Q000187:drug effects
chemical_list: D015335:Molecular Probes