Distinct evolution of calcium channel antibody types in Lambert-Eaton myasthenic syndrome.
To determine whether titers of anti-P/Q type and anti-N type calcium channel antibodies provide distinct information, both types of assay were performed during follow-up of 7 patients with Lambert-Eaton myasthenic syndrome (LEMS). In 4 patients with both antibody responses, titers evolved independently and often in an inverse relationship. Two patients with squamous cell lung carcinoma (SqCLC) produced anti-N type channel antibodies, but no detectable anti-P/Q channel responses. These results suggest that anti-N channel autoantibodies constitute an immune response distinct from the anti-P/Q type channel specificity and can also correlate with clinical evolution. Consequently combined assays may provide more comprehensive information during follow-up of LEMS.
Martin-Moutot
Nicole
N
INSERM, U641, Marseille F-13000, France. nicole.martin-moutot@univmed.fr
De Haro
Luc
L
Seagar
Michael
M
D000368:Aged; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood / Q000145:classification*; D020864:Calcium Channels, N-Type / Q000276:immunology; D020865:Calcium Channels, P-Type / Q000276:immunology*; D020907:Calcium Channels, Q-Type / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type