The relationship between obstructive sleep apnea, nocturia, and daytime overactive bladder syndrome in women.
OBJECTIVE
The purpose of this study was to corroborate the association between obstructive sleep apnea (OSA) and nocturia in a clinical sample of urogynecologic patients and to explore whether night-time urine concentration predicts the presence of OSA.


METHODS
Patients with nocturia and control subjects underwent a home sleep study, completed validated nocturia questionnaires, and provided evening and morning urine specimens that were analyzed for osmolarity.


RESULTS
Twenty-one patients with nocturia (16 of whom also had daytime overactive bladder [OAB] symptoms) and 10 control subjects were studied. OSA was present in 17 of 21 women (81%) with nocturia: 13 women (81%) with OAB, 4 women (80%) with nocturia/no OAB, and 4 control subjects (40%; P < .001). The percentage of rapid eye movement sleep time was correlated inversely with nocturic frequency (rho = -.51; P < .004). The presence of diluted nighttime urine in a patient with nocturia was 88% sensitive for the presence of OSA.


CONCLUSIONS
We should consider a diagnosis of OSA in all patients with nocturia, even those patients with daytime OAB.
Lowenstein
Lior
L
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola Medical Center, Chicago, IL 60153, USA. lowensteinMD@gmail.com
Kenton
Kimberly
K
Brubaker
Linda
L
Pillar
Giora
G
Undevia
Nidhi
N
Mueller
Elizabeth R
ER
FitzGerald
Mary Pat
MP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008875:Middle Aged; D053158:Nocturia / Q000175:diagnosis / Q000453:epidemiology*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000628:therapy; D012895:Sleep, REM; D011795:Surveys and Questionnaires; D053201:Urinary Bladder, Overactive / Q000453:epidemiology*