title: Computer-aided evaluation of anatomical accuracy of image fusion between X-ray CT and SPECT.
abstract: Hybrid scanners, which enable the performance of single photon emission computed tomography (SPECT) and X-ray computed tomography (CT) in one imaging session, have considerable diagnostic potential. However, evaluating the anatomical accuracy of image fusion inherent to these systems remains a challenge. This paper proposes a method for evaluating this variable with minimum user interaction. It focuses on measuring the distance between the centers of gravity of the SPECT hot spot and its counterpart in the CT image. A localized maximally stable extremal regions method is proposed to automatically segment SPECT hot spots, while the corresponding CT structures are segmented by the semi-automatic random walk method, based on a fast multigrid solver. Accuracy and reproducibility of the validation method have been preliminary confirmed by the test with 21 clinical data-sets.
authors.affiliation: Chair for Pattern Recognition, Friedrich-Alexander University, Martensstrasse 3, D-91058 Erlangen, Germany. jingfeng@informatik.uni-erlangen.de
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Han
authors.forename: Harald
authors.initials: H
authors.lastname: Köstler
authors.forename: Christian
authors.initials: C
authors.lastname: Bennewitz
authors.forename: Torsten
authors.initials: T
authors.lastname: Kuwert
authors.forename: Joachim
authors.initials: J
authors.lastname: Hornegger
mesh_terms: D000465:Algorithms; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*