Age-related peculiarities of contractile activity of rat myocardium during blockade of hyperpolarization-activated currents.
Contractile activity of atrial and ventricular myocardial strips isolated from rats of various age was examined under conditions of blockade of non-selective hyperpolarization-activated cation currents. Addition of ZD7288, a blocker of non-selective hyperpolarization-activated cation currents, to the perfusion solution increased the contraction force of atrial and ventricular strips in 1-, 8-, and 20-week rats, but produced an opposite effect on contractile activity of atrial and ventricular strips in 3-week rats.
Zefirov
T L
TL
Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian-Pedagogical University, Kazan. zefirovtl@mail.ru
Gibina
A E
AE
Sergejeva
A M
AM
Ziyatdinova
N I
NI
Zefirov
A L
AL
D000375:Aging / Q000502:physiology*; D000818:Animals; D002317:Cardiovascular Agents / Q000378:metabolism / Q000494:pharmacology; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000378:metabolism*; D006352:Heart Ventricles / Q000187:drug effects; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism / Q000494:pharmacology; D051381:Rats
D002317:Cardiovascular Agents; D054815:Cyclic Nucleotide-Gated Cation Channels; D011743:Pyrimidines; C082246:ICI D2788