title: A unique family of stable and water-soluble S-nitrosothiol complexes.
abstract: In this work, we present a complete and detailed experimental characterization and theoretical study of a variety of coordinated S-nitrosothiols (RSNOs), such as cysteine derivatives, mercaptosuccinic acid, benzyl thiol, and phenyl thiol. Some of them are extremely unstable and sensitive in free form. Strikingly, in contrast with free S-nitrosothiols, we found that, upon coordination to iridium, they become very stable even in aqueous solutions. The study of these coordinated complexes provides further insight on the elucidation of structural aspects dealing with the nature of the S-N bond in RSNOs, a fact which still remains a matter of controversy.
authors.affiliation: Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, (C1428EHA) Buenos Aires, Argentina.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Perissinotti
authors.forename: Gregory
authors.initials: G
authors.lastname: Leitus
authors.forename: Linda
authors.initials: L
authors.lastname: Shimon
authors.forename: Dario
authors.initials: D
authors.lastname: Estrin
authors.forename: Fabio
authors.initials: F
authors.lastname: Doctorovich
mesh_terms: D018360:Crystallography, X-Ray; D003545:Cysteine / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D017680:Potassium Compounds / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013870:Thiomalates / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D004952:Esters; D017680:Potassium Compounds; D026403:S-Nitrosothiols; D013870:Thiomalates; D014867:Water; C046062:2-thiomalic acid; D003545:Cysteine