title: Defining a pathway to discovery from bench to bedside: the trigeminovascular system and sensitization.
abstract: Over the past 50 years, investigations into the pathophysiology of migraine have yielded discoveries that both illuminate the various components of the "migraine process" and lend promise to the identification of new therapies unheralded in their specificity and effectiveness.
authors.affiliation: Neuroscience Center and the Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Moskowitz
mesh_terms: D002560:Cerebrovascular Circulation / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008578:Meninges / Q000098:blood supply; D008881:Migraine Disorders / Q000188:drug therapy / Q000266:history* / Q000503:physiopathology*; D014276:Trigeminal Nerve / Q000503:physiopathology*