Drug utilisation profile in the Italian paediatric population.
OBJECTIVE
In order to evaluate the prescribing pattern in the Italian paediatric population, prescriptions involving 923,353 children under 14 years old and dispensed during 2006 by the retail pharmacies of 22 Italian local health units were analysed.


METHODS
A total of 561,237 children (61%) received at least one drug prescription. The prescription prevalence rate was highest in children 3 years of age (78%), decreased with increasing age and was higher in boys than in girls (chi(2)=655; p<<0.001). Each treated child received an average of 3.2 prescriptions and 4.8 boxes.


RESULTS
Antibiotics and anti-asthmatics were the more prescribed therapeutic classes and represented 80% of prescriptions. Amoxicillin+clavulanic acid was the most prescribed drug (24% of the overall population; 17% of all boxes), followed by inhaled beclometasone and amoxicillin. A total of 620 different drugs were prescribed and the ten leading drugs represented 64% of the prescribed boxes. Six of the ten most prescribed drugs were the same in all age groups. Wide differences were found in the prevalence rate between the different local health units; these ranged between 50.1 and 68.4% (p<<0.001). The prescription prevalence increased in the 2000-2002 period (from 62.2 to 68.3%) and slightly decreased afterwards.


CONCLUSIONS
Despite some limitations, the systematic monitoring of prescriptions is a valuable tool for evaluating the appropriateness of the care.
Clavenna
Antonio
A
Laboratory for Mother and Child Health, Mario Negri Institute for Pharmacological Research, via G. La Masa 19, Milan 20156, Italy. clavenna@marionegri.it
Berti
Alessandra
A
Gualandi
Lucia
L
Rossi
Elisa
E
De Rosa
Marisa
M
Bonati
Maurizio
M
D000293:Adolescent; D000367:Age Factors; D000658:Amoxicillin / Q000627:therapeutic use; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001507:Beclomethasone / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D010372:Pediatrics / Q000706:statistics & numerical data*; D055553:Prescription Drugs / Q000627:therapeutic use*; D055656:Prescriptions / Q000706:statistics & numerical data; D012737:Sex Factors
D018927:Anti-Asthmatic Agents; D000900:Anti-Bacterial Agents; D055553:Prescription Drugs; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D001507:Beclomethasone