Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.
The role of CD26 in human T cell biology is puzzling. Despite being extensively characterized, it has been called 'a moonlighting protein' since it has multifunctional effects, but a definitive native ligand has not been identified. We summarize the current knowledge on the molecular mechanisms of CD26-mediated T cell costimulation and immune regulation. Work identifying a ligand for CD26 and elucidating the proximal signaling events associated with CD26-mediated T cell costimulation is also described. Finally, we discuss the involvement of CD26 in various pathophysiologic states as well as its suitability as a potential therapeutic target in selected immune diseases.
Ohnuma
Kei
K
Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Dang
Nam H
NH
Morimoto
Chikao
C
D000818:Animals; D001327:Autoimmune Diseases / Q000628:therapy; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D022461:Caveolins / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation; D018946:Chemokine CCL5 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D006162:Guanylate Cyclase / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D054731:PDZ Domains / Q000276:immunology; D011485:Protein Binding / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D053468:CARD Signaling Adaptor Proteins; D022461:Caveolins; D018946:Chemokine CCL5; D011948:Receptors, Antigen, T-Cell; D018819:Dipeptidyl Peptidase 4; C426242:CARD11 protein, human; D006162:Guanylate Cyclase