title: Protein farnesyltransferase and adenosine receptors.
abstract: Many exciting advances in the treatment of cancer were presented at the symposium entitled 'Protein prenylation' which was chaired by Professor Richard A Gibbs (Wayne State University, Detroit, MI, USA). Prenylation, or the covalent attachment of isoprenoid lipids, is now recognized as an important component in the post-translational localization and functionalization of many cellular proteins. The majority of prenylated proteins are modified by one of two specific enzymes: protein farnesyl-transferase (FTase) and geranylgerany-ltransferase type I (GGTase-I). The finding that farnesylation of oncogenic forms of Ras proteins is required for expression of their transforming activity has led to FTase becoming an important target for anticancer drug design.
authors.affiliation: Current Drugs Limited, Middlesex House, 34-42 Cleveland Street, London, W1P 6LB, UK. peterro@cursci.co.uk
authors.forename: P
authors.initials: P
authors.lastname: Robins