Component exchange as a synthetically advantageous strategy for the preparation of bicyclic cage compounds.
Macrobicyclic triphosphazides are able to reversibly exchange one of their tripodal components by means of a dynamic disassembly-reassembly process; surprisingly this strategy provides better yields of cage compounds than a direct tripod-tripod coupling.
Alajarín
Mateo
M
Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain. alajarin@um.es ppberna@um.es
Berná
José
J
López-Leonardo
Carmen
C
Steed
Jonathan W
JW
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry
D000588:Amines; D001386:Azides; D001643:Bridged Bicyclo Compounds; D047028:Macrocyclic Compounds; D063065:Organophosphonates; D010720:Phosphines; C044646:phosphine