title: Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
abstract: It has been reported that antibodies (Abs) against heterogeneous nuclear ribonucleoproteins (hnRNPs) are associated with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). However, these studies were done under nonmasked conditions. In order to determine whether Abs against hnRNPs associate with HAM/TSP and MS, the authors assayed Abs against two major hnRNPs, hnRNP A1 and A2/B1, in 105 cerebrospinal fluid (CSF) samples under fully masked conditions. Samples included 40 cases of HAM/TSP, 28 of MS, and 37 of other neurological diseases. Anti-hnRNP A1 Abs, and especially anti-hnRNP A2/B1 Abs, were found significantly more often in the CSF of MS patients than in other groups. However, there was no difference in the incidence of anti-hnRNP A1 Abs between HAM/TSP and other disease groups.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. yukitake@cc.saga-u.ac.jp
authors.forename: Motohiro
authors.initials: M
authors.lastname: Yukitake
authors.forename: Eisaburo
authors.initials: E
authors.lastname: Sueoka
authors.forename: Naoko
authors.initials: N
authors.lastname: Sueoka-Aragane
authors.forename: Akemi
authors.initials: A
authors.lastname: Sato
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ohashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yakushiji
authors.forename: Mineki
authors.initials: M
authors.lastname: Saito
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
authors.forename: Shuji
authors.initials: S
authors.lastname: Izumo
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000917:Antibody Formation; D001323:Autoantibodies / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D001921:Brain / Q000378:metabolism; D015481:HTLV-I Antibodies; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000134:cerebrospinal fluid* / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology*; D015493:Paraparesis, Tropical Spastic / Q000276:immunology; D011897:Random Allocation
chemical_list: D001323:Autoantibodies; D015481:HTLV-I Antibodies; D034441:Heterogeneous-Nuclear Ribonucleoproteins