Acute myeloid leukemia and myelodysplastic syndrome following breast cancer: increased frequency of other cancers and of cancers in multiple family members.
Adjuvant chemotherapy and radiation therapy for breast cancer are associated with therapy-related acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS), but little is known about additional risk factors. Thirty-four patients with AML (n=26)/MDS (n=8) following breast cancer (cases) were compared with 2029 breast cancer patients without AML/MDS (controls). Cases were older at breast cancer diagnosis (mean 60.2 years versus 54.5 years; p=0.01) and more commonly had additional cancers (29% versus 4.9%; p<0.0001) and >or=4 first-degree relatives with any type of cancer (OR: 5.37, CI: 1.44-19.9). Thus risk factors for AML/MDS following breast cancer include older age, other cancers and multiple first-degree relatives with cancer.
Padmanabhan
Aruna
A
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Baker
Julie A
JA
Zirpoli
Gary
G
Sait
Sheila N J
SN
Ford
Laurie A
LA
Moysich
Kirsten B
KB
Baer
Maria R
MR
D001943:Breast Neoplasms / Q000150:complications* / Q000235:genetics; D005190:Family; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology* / Q000235:genetics; D009369:Neoplasms / Q000150:complications*; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000235:genetics; D009679:Nuclear Family