Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.
The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.
Perkhofer
Susanne
S
Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. Susanne.Perkhofer@i-med.ac.at
Locher
Maria
M
Cuenca-Estrella
Manuel
M
Rüchel
Reinhard
R
Würzner
Reinhard
R
Dierich
Manfred P
MP
Lass-Flörl
Cornelia
C
D020095:Absidia / Q000187:drug effects; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D020093:Cunninghamella / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D025301:Hyphae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects; D009090:Mucorales / Q000187:drug effects* / Q000472:pathogenicity / Q000648:ultrastructure; D009091:Mucormycosis / Q000188:drug therapy / Q000382:microbiology; D020103:Rhizomucor / Q000187:drug effects; D012233:Rhizopus / Q000187:drug effects; D013172:Spores, Fungal / Q000187:drug effects; D014230:Triazoles / Q000008:administration & dosage*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B