Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii.
Two new labdane diterpenes, 8alpha,19-dihydroxylabd-13 E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8alpha,12,14-triol (2), as well as an acetylated derivative, 8alpha-O-beta-D-glucopyranosyllabd-13 E-ene-15,19-diol-8alpha-2',3',4',6'-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.
Hegazy
Mohamed-Elamir F
ME
Chemistry of Medicinal Plant Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Ohta
Shinji
S
Abdel-Latif
Fathy F
FF
Albadry
Hazem A
HA
Ohta
Emi
E
Paré
Paul W
PW
Hirata
Toshifumi
T
D000972:Antineoplastic Agents, Phytogenic; D019659:Asteraceae / Q000737:chemistry*; D002163:Cameroon; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007527:Isoenzymes; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; D007527:Isoenzymes