title: Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.
abstract: Pharmacokinetics of an original compound GB-115 (N-phenylhexanoylglycyltryptophan) synthesized on the basis of the structure of endogenous tetrapeptide cholecystokinin-4 was studied by means of high-performance liquid chromatography. Pharmacokinetic parameters were calculated after intravenous and peroral administration of GB-115. Our results indicate that this dipeptide is resistant to peptidases. The absolute bioavailability of GB-115 is 4.65%.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Sciences, Moscow. sarpharm@mail.ru
authors.forename: S S
authors.initials: SS
authors.lastname: Boyko
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: E P
authors.initials: EP
authors.lastname: Kiryanova
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000008:administration & dosage / Q000235:genetics / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D014364:Tryptophan / Q000737:chemistry
chemical_list: D004151:Dipeptides; C520797:GB-115; D014364:Tryptophan