title: The discovery and development of the triptans, a major therapeutic breakthrough.
abstract: The drug discovery programs that led to the development of the triptans were determined by the membership of the American Headache Society to be the most important breakthrough in headache medicine in the last 50 years. Dr. Humphrey, who spearheaded the drug discovery, recounts the pioneering work that took place and examines its therapeutic impact.
authors.affiliation: Theravance Inc., South San Francisco, California, USA.
authors.forename: Patrick P A
authors.initials: PP
authors.lastname: Humphrey
mesh_terms: D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000266:history / Q000503:physiopathology; D011985:Receptors, Serotonin / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000266:history / Q000627:therapeutic use; D018170:Sumatriptan / Q000266:history / Q000627:therapeutic use; D014363:Tryptamines / Q000266:history* / Q000627:therapeutic use*
chemical_list: D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; D018170:Sumatriptan