title: Effects of physical training on bone mineral density in fertile women with idiopathic osteoporosis.
abstract: The aim of this study was to investigate whether moderate physical training can improve the bone mineral density (BMD) in women with idiopathic osteoporosis. Ten pre-menopausal women aged 24-44 years diagnosed with idiopathic osteoporosis were included in the study. The physical training program consisted of three fast 30-min walks plus one or two sessions of 1-h training per week during 1 year at a training centre separate from the hospital. All patients were given supplements of vitamin D and calcium. Bone mineral density was measured in the femoral neck area and the lumbar spine by dual energy X-ray absorptiometry. The measurements were performed at baseline and after 12 months of training and compared with the measurements at the time of diagnosis, 1-3 years before the study. Eight women fulfilled the 12-month training period, and their mean (SD) BMD at start was 0.88 (0.08) g/cm(2) in the spine and 0.76 (0.13) g/cm(2) in the femoral neck. The mean spine BMD increase was 0.031 g/cm(2) (3.5%) after 1 year of training, which was significant (Wilcoxon's non-parametric test, p = 0.018). The mean increment in BMD in the femoral neck was insignificant, 0.007 g/cm(2) (0.9%) after the intervention (p = 0.74). However, the bone loss during the 1- to 3-year period from diagnosis to study start was, on average, 0.045 g/cm(2) or 5.0% in the femoral neck (p = 0.042), thus indicating a positive indirect effect of the intervention. There is no evidence-based therapy for women with idiopathic osteoporosis. It is therefore of importance to elucidate the impact of moderate physical activity in this group of patients. A 1-year training program was sufficient to induce a small but significant change in the spine BMD.
authors.affiliation: Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Huddinge, M52, Stockholm, 141 86, Sweden. ingrid.b.bergstrom@karolinska.se
authors.forename: Ingrid
authors.initials: I
authors.lastname: Bergström
authors.forename: Jonas
authors.initials: J
authors.lastname: Brinck
authors.forename: Maria
authors.initials: M
authors.lastname: Sääf
mesh_terms: D000328:Adult; D015519:Bone Density; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D005272:Femur Neck / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D010024:Osteoporosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D010806:Physical Education and Training / Q000379:methods; D016896:Treatment Outcome