Impact of mecA gene testing and intervention by infectious disease clinical pharmacists on time to optimal antimicrobial therapy for Staphylococcus aureus bacteremia at a University Hospital.
In patients with Staphylococcus aureus bacteremia, intervention by infectious disease clinical pharmacists on the basis of the results of tests for mecA resulted in a 25.4-h reduction in the time to optimal antimicrobial therapy, from 64.7 +/- 36.8 to 39.3 +/- 15.5 h (P = 0.002), which may result in decreased mortality.
Carver
Peggy L
PL
Department of Clinical Sciences, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, Michigan 48109-0008, USA. peg@umich.edu
Lin
Shu-Wen
SW
DePestel
Daryl D
DD
Newton
Duane W
DW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D046915:Penicillin-Binding Proteins; D010595:Pharmacists; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; C487789:mecA protein, Staphylococcus aureus