title: IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions.
abstract: Protein synthesis in general is suppressed under hypoxic conditions in both cancer cells and normal cells. In human pancreatic cancer AsPC-1 cells, which are resistant to low oxygen tension, protein synthesis at day 4 under hypoxia (1% O(2)) was about 20% of that under normoxia. Secretion of some proteins actually increased in spite of a general reduction in protein synthesis; two of these proteins were insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3. Hypoxia also induced transcription of multiple IGFBPs. The IGFBPs contributed to reduced IGF signaling and to the survival of cancer cells under conditions of low oxygen tension.
authors.affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Koga
authors.forename: Hiroko
authors.initials: H
authors.lastname: Endo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Mukai
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inoue
mesh_terms: D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D002470:Cell Survival; D017077:Culture Media, Conditioned; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D014176:Protein Biosynthesis
chemical_list: D017077:Culture Media, Conditioned; D018969:Insulin-Like Growth Factor Binding Proteins