title: The Rome III Classification of dyspepsia: will it help research?
abstract: A major change in the Rome III criteria relates to the condition previously called functional dyspepsia (FD). Rome I and Rome II defined FD as pain or discomfort centered in the upper abdomen without a definite structural or biochemical explanation. The condition was further sub-classified into ulcer-like or dysmotility-like dyspepsia. However, subsequent studies failed to show that single-symptoms are present in the vast majority of patients, and most symptoms failed to correlate with any physiological abnormalities. In Rome III, FD as a broad category was no longer considered useful in terms of research, but rather was defined by two new symptom entities, namely epigastric pain (epigastric pain syndrome) and meal-related symptoms (postprandial distress syndrome). We predict these changes will stimulate new research into the underlying pathophysiological disturbances, as well as impact the diagnosis and treatment of dyspepsia; the classification should advance the field, and we review the challenges ahead.
authors.affiliation: Mayo Clinic College of Medicine, Jacksonville, Fla., USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Talley
authors.forename: Kevin
authors.initials: K
authors.lastname: Ruff
authors.forename: Xuan
authors.initials: X
authors.lastname: Jiang
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Jung
mesh_terms: D004415:Dyspepsia / Q000145:classification* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000502:physiology; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D008297:Male; D019518:Postprandial Period; D011379:Prognosis; D012106:Research / Q000592:standards / Q000639:trends
chemical_list: D005765:Gastrointestinal Agents