[Regulation of energy metabolism by bone].
In terms of feedback regulation in Endocrinology, one question was arisen from the evidences that energy metabolism regulates bone metabolism. "Does bone metabolism regulates energy metabolism?" To address this question, Dr. Gerard Karsenty and his colleagues studied energy metabolism in the mice lacking Osteocalcin, an osteoblast-specific gene. The mutant mice exhibited abnormal energy metabolism phenotypes, diabetes and obesity. Here I would like to remind you his previous and recent works so that we can discuss how to apply bone metabolism information to therapeutic strategy for metabolic syndrome.
Sowa
Hideaki
H
Columbia University, Genetics and Development.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000209:etiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D024821:Metabolic Syndrome / Q000209:etiology; D051379:Mice; D009765:Obesity / Q000209:etiology; D015675:Osteocalcin / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3 / Q000502:physiology
D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C525947:exocrine-gland-secreting peptide 1, mouse; D015675:Osteocalcin; C474713:Ptprv protein, mouse; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3