title: Needle-shaped deposits on retinal surface in a case of ocular amyloidosis.
abstract: OBJECTIVE
  To report a case in which optical coherence tomography (OCT) showed needle-shaped deposits on the retinal surface oriented toward the vitreous cavity and immunohistochemical findings suggested light chain-related amyloidosis.
  
  
  METHODS
  A 59-year-old man with no systemic complications had bilateral neovascular glaucoma and vitreous opacities in the right eye. Vitrectomy was conducted on the right eye and the excised vitreous was examined histopathologically.
  
  
  RESULTS
  Glass wool-like opacities were observed during vitrectomy. Postoperative fundus examination of the right eye showed retinal hemorrhage and white deposits around blood vessels and on retinal surface. Fluorescein angiography revealed hyperfluorescence of the optic disc, non-perfusion areas, and vascular focal staining. OCT depicted needle-shaped deposits perpendicular to the retinal surface oriented toward the vitreous. Histologic examination of deposits revealed positive reaction for Congo red stain, and immunohistochemical examination demonstrated positive reactivities for anti-lambda and anti-kappa light chains (precursors of amyloid protein), suggesting a diagnosis of light chain-related amyloidosis.
  
  
  CONCLUSIONS
  In this case, OCT showed needle-shaped deposits perpendicular to the retinal surface. Special staining with Congo red revealed the deposit to be amyloid deposition. Immunohistochemical staining suggested light chain-related amyloidosis. Vascular obstructive lesions and neovascular glaucoma secondary to retinal vascular damage in amyloidosis warrant particular attention.
authors.affiliation: Department of Ophthalmology, School of Medicine, Nihon University, Tokyo - Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Yuzawa
authors.forename: N
authors.initials: N
authors.lastname: Kinukawa
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000378:metabolism; D005128:Eye Diseases / Q000175:diagnosis / Q000601:surgery; D005451:Fluorescein Angiography; D015355:Glaucoma, Neovascular / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000175:diagnosis* / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology
chemical_list: D000685:Serum Amyloid A Protein