title: A highly specific BODIPY-based fluorescent probe for the detection of hypochlorous acid.
abstract: A fluorescent probe, HKOCl-1, has been successfully developed for the detection of hypochlorous acid on the basis of a specific reaction with p-methoxyphenol. The formation of HOCl has been successfully detected not only in an abiotic system but also in an enzymatic system (myeloperoxidase/H2O2/Cl(-) system) and in living macrophage cells upon stimulation. This new probe might be used as an efficient tool for probing the roles HOCl plays in biological systems.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Hong Kong, P.R. China.
authors.forename: Zhen-Ning
authors.initials: ZN
authors.lastname: Sun
authors.forename: Feng-Qin
authors.initials: FQ
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Paul Kwong Hang
authors.initials: PK
authors.lastname: Tam
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006997:Hypochlorous Acid / Q000032:analysis* / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D006997:Hypochlorous Acid