A new definition of solubilization power of a cosolvent.
The solubilization power of a cosolvent is defined based on the maximum solubility of a solute in the water-cosolvent mixtures (X(m,max)) and the corresponding solvent composition (f(c,max)) predicted by trained versions of the Jouyban-Acree model. The applicability of the proposed definition was checked using solubility data of three cosolvent systems where the solubilization power was ordered as: dioxane > ethanol > polyethylene glycol 400. Using this definition, one could select the most appropriate cosolvent for solubilization of a poorly water soluble drug. There are linear relationships between the solubilization power of a cosolvent and the solute's logarithm of partition coefficients.
Jouyban
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A
Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ajouyban@hotmail.com
Fakhree
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MA
D000465:Algorithms; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D012997:Solvents / Q000737:chemistry*; D013696:Temperature; D009626:Terminology as Topic
D012997:Solvents