title: Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT6 receptor ligands.
abstract: The synthesis of new pharmaceutically interesting 3-(2-N,N-diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield. Further sulfonylation of these novel indoles gave access to potential 5-HT(6) receptor ligands.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany.
authors.forename: Karolin
authors.initials: K
authors.lastname: Alex
authors.forename: Nicolle
authors.initials: N
authors.lastname: Schwarz
authors.forename: Vivek
authors.initials: V
authors.lastname: Khedkar
authors.forename: Iliyas Ali
authors.initials: IA
authors.lastname: Sayyed
authors.forename: Annegret
authors.initials: A
authors.lastname: Tillack
authors.forename: Dirk
authors.initials: D
authors.lastname: Michalik
authors.forename: Jörg
authors.initials: J
authors.lastname: Holenz
authors.forename: José Luis
authors.initials: JL
authors.lastname: Díaz
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D017606:Chlorine Compounds / Q000737:chemistry; D005019:Ethyl Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D005021:Ethylamines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D017606:Chlorine Compounds; D005019:Ethyl Ethers; D005021:Ethylamines; D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin