Involvement of insula and cingulate cortices in control and suppression of natural urges.
The physiology of control and suppression of natural urges is not well understood. We used [(15)O]H(2)O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.
Lerner
Alicja
A
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. lernera@mail.nih.gov
Bagic
Anto
A
Hanakawa
Takashi
T
Boudreau
Eilis A
EA
Pagan
Fernando
F
Mari
Zoltan
Z
Bara-Jimenez
William
W
Aksu
Murat
M
Sato
Susumu
S
Murphy
Dennis L
DL
Hallett
Mark
M
D000328:Adult; D001767:Blinking / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004328:Drive; D005246:Feedback / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D007266:Inhibition, Psychological; D033182:Intention; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009433:Neural Inhibition / Q000502:physiology*; D055815:Young Adult