title: Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis.
abstract: OBJECTIVE
  To quantitatively summarize the association between tumour necrosis factor alpha (TNF-alpha) gene polymorphisms and Graves' disease.
  
  
  METHODS
  Relevant studies were identified from the following electronic databases: Cochrane Library, MEDLINE, EMBASE and Chinese Bio-medicine Database. A meta-analysis of relevant studies was performed.
  
  
  RESULTS
  This meta-analysis included 10 case-control studies, which included 2271 Graves' disease cases and 2633 controls. The combined results based on all studies showed that there was significant difference in genotype distribution (-308A/G; -308G/G; -863C/C; -863C/A; -1031C/T) between Graves' disease and controls. When stratifying for race, statistically significant results were observed in three genotype distribution (-863C/C; -863C/A; -1031C/T) between Graves' disease and controls among Asians. Statistically significant results were observed in only two genotype distribution (-308A/G; -308G/G) between Graves' disease and controls among Caucasians.
  
  
  CONCLUSIONS
  This meta-analysis suggests that TNF-alpha gene polymorphisms at positions -308 (G-308A), -863 (C-863A), and -1031 (T-1031C) were associated with Graves' disease.
authors.affiliation: Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Li
authors.forename: Zongguang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xuyang
authors.initials: X
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Junjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Du
authors.forename: Maoling
authors.initials: M
authors.lastname: Wei
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D005838:Genotype; D006111:Graves Disease / Q000235:genetics*; D006801:Humans; D018579:Patient Selection; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha