Evaluation of the characteristics of oral dosage forms with release controlled by erosion.
This paper is concerned with oral dosage forms with controlled release based on the erosion of the polymer matrix. A numerical model taking all the facts into account, i.e., the kinetics of release and pharmacokinetic parameters of the drug, makes it possible to calculate the plasma drug level. Diagrams are built which connect the half life times obtained either through i.v. or with these dosage forms as a function of the full time of erosion of the polymer. Thus, it is possible to determine the right dosage form matrix associated with the desired therapy. Their interest stands for possible bioadhesion extending the gastrointestinal tract time.
Rosca
Iosif-Daniel
ID
Concordia University, Montreal, Quebec, Canada.
Vergnaud
Jean-Maurice
JM
D000284:Administration, Oral; D003198:Computer Simulation; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations