title: Asymmetric reduction of benzil to (S)-benzoin with Penicillium claviforme IAM 7294 in a liquid-liquid interface bioreactor (L-L IBR).
abstract: The asymmetric reduction of benzyl to (S)-benzoin with Penicillium claviforme IAM 7294 was applied to a liquid-liquid interface bioreactor (L-L IBR) using a unique polymeric material, ballooned microsphere (MS). The L-L IBR showed superior performance, as compared with suspension, organic-aqueous two-liquid-phase, and solid-liquid interface bioreactor (S-L IBR) systems, affording 14.4 g/l-organic phase of (S)-benzoin (99.0% ee).
authors.affiliation: Bioresource Laboratories, Mercian Corporation, Iwata, Shizuoka 438-0078, Japan. odas@neptune.kanazawa-it.ac.jp
authors.forename: Shinobu
authors.initials: S
authors.lastname: Oda
authors.forename: Kunio
authors.initials: K
authors.lastname: Isshiki
mesh_terms: D001573:Benzoin / Q000378:metabolism*; D019149:Bioreactors / Q000382:microbiology*; D008863:Microspheres; D010084:Oxidation-Reduction; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D010658:Phenylglyoxal / Q000031:analogs & derivatives* / Q000378:metabolism; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D001573:Benzoin; D010658:Phenylglyoxal; C006697:benzil