title: Novel osmotic pump tablet using core of drug-resin complexes for time-controlled delivery system.
abstract: A novel elementary osmotic pump tablet was developed. The system uses the core of drug-resin complexes (DRCs) loaded with propranolol hydrochloride (PNH) for time-controlled delivery. In traditional osmotic pump tablets (OPTs), the lag time was always minimized. However, in the DRCs osmotic pump tablet (DRCOPT), the lag time was increased to achieve the time-controlled delivery. The quantity of osmotic agent in the core and channeling agent in the coating solution as well as weight gain were confirmed to be essential for the release behavior. A spherical symmetric design was applied to the optimization of the DRCOPT. The optimal formulation mainly consisted of DRC 100 mg, polyethyleneoxide (N80) 182 mg, and NaCl 30 mg. The ratio of cellulose acetate (CA)/polyethylene glycol 4000 was 15:3 (w/w) in coating solution, and the weight gain was 8%. The release behavior of the optimal DRCOPT was evaluated in media with different pH, rotation speeds, and ionic strength. It was found to generate a 2-h lag time, to deliver PNH at a rate of zero order from 2 h to 14 h in the medium of NaCl 0.15 mol/l, and the cumulative release at 24 h was 94%. Drug relee was independent of pH and rotation speed, but was proportional to ionic strength. In summary, the lag time could be used in therapeutic regimens with the characteristics of chronotherapy because of the lag time and provides a new concept for the development of osmotic pumps.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Ji-zhong
authors.initials: JZ
authors.lastname: Li
authors.forename: Hai
authors.initials: H
authors.lastname: Tang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Ke-shu
authors.initials: KS
authors.lastname: Yan
authors.forename: Guan-hao
authors.initials: GH
authors.lastname: Ye
authors.forename: Wei-san
authors.initials: WS
authors.lastname: Pan
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D019454:Chronotherapy; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D015195:Drug Design; D009995:Osmosis; D011092:Polyethylene Glycols; D011433:Propranolol / Q000008:administration & dosage*; D012965:Sodium Chloride; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; C005062:acetylcellulose; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D002482:Cellulose; D011433:Propranolol