[Chronic recurrent candidiasis of the genitalia in females due to non-albicans Candida spp].
1346 women with the symptoms of chronic recurrent urogenital infection were examined. The diagnosis of genital candidiasis was confirmed by the clinical manifestations (not less than its 4 episodes a year) and laboratory tests: budding fungal cells, mycelium and/or pseudomyselium in the vaginal smears detected microscopically, growth of Candida spp. on the Sabouraud's medium. The species of the isolates were determined by the standard morphological and biochemical tests. The in vitro susceptibility to fluconazole and voriconazole was evaluated by the disk diffusion method (Protocol CLSI M44-A). The frequency of chronic recurrent genital candidiasis in women with chronic urogenital infection amounted to 19%. The pathogens of the disease belonged to 12 species of Candida. The main pathogen was Candida albicans (83%). Most of the isolates (88%) were susceptible to fluconazole. 99.5% of the isolates was susceptible to voriconazole. The isolates resistant to fluconazole mainly belonged to non-albicans (41% vs. 1% of Candida albicans) and were obviously more frequent under the following conditions: the age of the females above 36 years (including the periods of peri- and postmenopause), frequent relapses (at least 7 a years), atypical clinical and laboratory signs.
Mirzabalaeva
A K
AK
Dolgo-Saburova
Iu V
IuV
D000293:Adolescent; D000328:Adult; D000368:Aged; D002175:Candida; D002176:Candida albicans; D002908:Chronic Disease; D025141:Drug Resistance, Fungal; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D014848:Vulvovaginitis / Q000188:drug therapy / Q000382:microbiology