Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets.
Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.
Braumann
Chris
C
Department of General, Visceral, Vascular and Thoracic Surgery, - Universitätsmedizin Berlin, Monbijoustrasse 2, 10117 Berlin, Germany.
Tangermann
Judith
J
Jacobi
Christoph A
CA
Müller
Joachim M
JM
Dubiel
Wolfgang
W
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D000075686:COP9 Signalosome Complex; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D004642:Emodin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D009369:Neoplasms / Q000188:drug therapy*; D010447:Peptide Hydrolases / Q000096:biosynthesis; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013654:Taurine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013829:Thiadiazines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D046912:Multiprotein Complexes; D047428:Protein Kinase Inhibitors; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D003474:Curcumin; D004642:Emodin