Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.
Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men.


METHODS
ghrelin (1 microg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.
Coiro
Vittorio
V
Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci, 14-43100 Parma, Italy. vittorio.coiro@unipr.it
Saccani-Jotti
Gloria
G
Rubino
Pasquale
P
Manfredi
Guido
G
Vacca
Paola
P
Volta
Elio
E
Chiodera
Paolo
P
D000328:Adult; D004347:Drug Interactions / Q000502:physiology; D054439:Ghrelin / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D010121:Oxytocin / Q000494:pharmacology / Q000502:physiology*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
D054439:Ghrelin; D009478:Neuropeptide Y; D010121:Oxytocin