Efficacy of intravitreal ceftazidime in acute postoperative endophthalmitis.
OBJECTIVE
To assess the efficacy of intravitreal ceftazidime in acute postoperative endophthalmitis.


METHODS
Quasi experimental study.


METHODS
Department of Ophthalmology Unit I, Eye Hospital, Liaquat University of Medical and Health Sciences, Hyderabad, from November 2004 to November 2006.


METHODS
Twenty-one eyes of 21 patients of acute postoperative endophthalmitis were treated with intravitreal antibiotic ceftazidime. The inclusion criteria of the patients was the clinical diagnosis of acute postoperative endophthalmitis within 15 days of postoperative period with visual acuity better than or equal to hand movement close to face. After enrollment, vitreous tap was carried out in all cases followed by intravitreal ceftazidime injection. The outcome was measured in terms of clinical resolution of endophthalmitis and postresolution best corrected visual acuity. Mean of difference was tested by paired t-test.


RESULTS
Nineteen eyes (90.5%) responded to intravitreal ceftazidime therapy alone, while an additional pars plana vitrectomy was required in one eye. Sixteen eyes (84%) retained a visual acuity of 6/60 or better at 3 months after the initiation of the therapy (p<0.001). Retinal detachment developed in one eye receiving intravitreal therapy.


CONCLUSIONS
Ceftazidime was effective as intravitreal therapy for the management of acute postoperative endophthalmitis.
Narsani
Ashok Kumar
AK
Department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh. amnarsani@hotmail.com
Jatoi
Shafi Muhammad
SM
Gul
Siddiqa
S
Dabir
Syed Asher
SA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002387:Cataract Extraction / Q000009:adverse effects; D002442:Ceftazidime / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002442:Ceftazidime