title: Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.
abstract: Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.
authors.affiliation: Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan. yhayashi@ps.toyaku.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Thomas
authors.initials: T
authors.lastname: Regnier
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nishiguchi
authors.forename: Magne O
authors.initials: MO
authors.lastname: Sydnes
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Junya
authors.initials: J
authors.lastname: Hasegawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Katoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Masataka
authors.initials: M
authors.lastname: Shiozuka
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Matsuda
authors.forename: Manabu
authors.initials: M
authors.lastname: Node
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiso
mesh_terms: D000599:Amino Acids, Diamino / Q000138:chemical synthesis; D005563:Formic Acid Esters / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000599:Amino Acids, Diamino; D005563:Formic Acid Esters; C000345:t-butyloxycarbonyl group; C015662:2-aminoacetaldehyde; C100200:negamycin; D005998:Glycine