title: Intravitreal bevacizumab and augmented trabeculectomy for neovascular glaucoma in young diabetic patients.
abstract: OBJECTIVE
  To report two cases of young diabetic patients with intractable neovascular glaucoma (NVG) who were successfully managed with bevacizumab and mitomycin C-augmented trabeculectomy.
  
  
  RESULTS
  Two young patients present with severe NVG secondary to diabetic proliferative retinopathy. The glaucoma was unresponsive to conventional medical therapy and complete panretinal photocoagulation. Both patients underwent augmented trabeculectomy with MMC and intravitreal injection of bevacizumab. Iris rubeosis resolved within 48 h. Both patients have a follow-up period of 6 months and the intraocular pressure (IOP) remain between 10-15 mmHg.
  
  
  CONCLUSIONS
  Controlling IOP due to NVG in young diabetic patients is difficult and augmented trabeculectomy has a very high failure rate. The addition of intravitreal bevacizumab in the management of NVG particularly in young diabetic patients may improve the success rate of IOP control. It is known that bevacizumab retards neovascularisation. It may also be modulating wound-healing response as well. Bevacizumab may have a potential role in the surgical management of NVG.
authors.affiliation: Department of Ophthalmology, Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland. kurtsc01@yahoo.co.uk
authors.forename: K Spiteri
authors.initials: KS
authors.lastname: Cornish
authors.forename: S
authors.initials: S
authors.lastname: Ramamurthi
authors.forename: S
authors.initials: S
authors.lastname: Saidkasimova
authors.forename: K
authors.initials: K
authors.lastname: Ramaesh
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D015355:Glaucoma, Neovascular / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D058449:Intravitreal Injections; D014130:Trabeculectomy / Q000379:methods; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab