title: Stem cells and Parkinson's disease: toward a treatment, not a cure.
abstract: Early clinical trials designed to treat Parkinson's disease by transplantation of fetal tissue containing dopamine neuron precursors yielded promising results, but the approach retains several limitations. Multiple recent papers describe longer-term outcomes in these patients, and two additional studies offer novel approaches that may lead to autologous sources of transplantable dopamine neurons.
authors.affiliation: Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI 53705, USA. cnsvendsen@wisc.edu
authors.forename: Clive
authors.initials: C
authors.lastname: Svendsen
mesh_terms: D000818:Animals; D054338:Cell Transdifferentiation; D002986:Clinical Trials as Topic; D004298:Dopamine / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000473:pathology / Q000502:physiology*; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy*; D051381:Rats; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000473:pathology / Q000502:physiology
chemical_list: D004298:Dopamine