title: Effects of coumestrol on lipid and glucose metabolism as a farnesoid X receptor ligand.
abstract: In the course of an effort to identify novel agonists of the farnesoid X receptor (FXR), coumestrol was determined to be one such ligand. Reporter and in vitro coactivator interaction assays revealed that coumestrol bound and activated FXR. Treatment of Hep G2 cells with coumestrol stimulated the expression of FXR target genes, thereby regulating the expression of target genes of the liver X receptor and hepatocyte nuclear factor-4alpha. Through these actions, coumestrol is expected to exert beneficial effects on lipid and glucose metabolism.
authors.affiliation: Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kanayama
authors.forename: Takuya
authors.initials: T
authors.lastname: Yashiro
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Kondo
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Murase
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hase
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tokimitsu
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Nishikawa
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Sato
mesh_terms: D001055:Apolipoproteins B / Q000378:metabolism; D002460:Cell Line; D003375:Coumestrol / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000819:agonists* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics; D048789:Phytoestrogens / Q000494:pharmacology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000378:metabolism; D014157:Transcription Factors / Q000819:agonists* / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001055:Apolipoproteins B; D003375:Coumestrol; D004268:DNA-Binding Proteins; D005947:Glucose; D008024:Ligands; D048789:Phytoestrogens; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated