title: Pooled analysis of elderly patients with non-small cell lung cancer treated with front line docetaxel/gemcitabine regimen: the Hellenic Oncology Research Group experience.
abstract: BACKGROUND
  Thirty to 40% of patients with non-small cell lung cancer (NSCLC) are older than 70 years and rarely are enrolled in clinical trials. Moreover, in clinical practice, > 75% of patients older than 65 years with metastatic NSCLC never receive any kind of chemotherapy.
  
  
  OBJECTIVE
  To retrospectively evaluate the impact of age on efficacy and toxicity of chemotherapy regimens in patients with advanced NSCLC treated with the docetaxel-gemcitabine combination.
  
  
  METHODS
  Pooled data from six clinical trials of the Hellenic Oncology Research Group were analyzed. According to their age, patients were divided into two groups: those with age < 70 years and those with > or = 70 years.
  
  
  RESULTS
  A total of 858 patients were included in this analysis. Six hundred sixty-six (77.6%) patients were younger than 70 years, whereas 192 (22.4%) patients where > or = 70-year-old. Overall response rate was 30.3% and 30.2% for patients < 70 years and > or = 70 years, respectively (p = 0.974). The median time to tumor progression was 4.1 and 4.5 months for patients < 70 years and > or = 70 years, respectively (p = 0.948). Median overall survival was 9.9 and 9.2 months for patients < 70 and > or = 70, respectively (p = 0.117). The multivariate analysis revealed performance status (PS) (p = 0.0001) and stage (p = 0.0001) as independent factors with significant impact on the hazard of death. Chemotherapy was well tolerated, but the incidence of grade III/IV mucositis was significantly higher in elderly patients (0.2% versus 1.5% for patients < 70 versus > or = 70 years, respectively; p = 0.011).
  
  
  CONCLUSIONS
  The docetaxel/gemcitabine regimen has a comparable efficacy and tolerance in young (< 70 years) and elderly (> or = 70 years) patients.
authors.affiliation: Hellenic Oncology Research Group (HORG), Athens, Greece.
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Pallis
authors.forename: Aris
authors.initials: A
authors.lastname: Polyzos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Boukovinas
authors.forename: Athina
authors.initials: A
authors.lastname: Agelidou
authors.forename: Lambros
authors.initials: L
authors.lastname: Lamvakas
authors.forename: Xanthi
authors.initials: X
authors.lastname: Tsiafaki
authors.forename: Maria
authors.initials: M
authors.lastname: Agelidou
authors.forename: Georgia
authors.initials: G
authors.lastname: Pavlakou
authors.forename: Vassilis
authors.initials: V
authors.lastname: Chandrinos
authors.forename: Stelios
authors.initials: S
authors.lastname: Kakolyris
authors.forename: Charalambos
authors.initials: C
authors.lastname: Christophyllakis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kentepozidis
authors.forename: Stelios
authors.initials: S
authors.lastname: Giassas
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Androulakis
authors.forename: Sophia
authors.initials: S
authors.lastname: Agelaki
authors.forename: Vassilis
authors.initials: V
authors.lastname: Georgoulias
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality; D002986:Clinical Trials as Topic; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018450:Disease Progression; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D015996:Survival Rate; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D014747:Vinblastine; D000077235:Vinorelbine; D000093542:Gemcitabine