Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia.
The serum IgM level has been utilised as a marker of tumor progression and to assess response to therapy in patients with Waldenstrom macroglobulinemia (WM). However, there are many limitations to the IgM protein level. The objective of this study was to evaluate the association of known tumor burden markers and prognostic factors with serum free light chain (sFLC) in 98 patients with WM. We demonstrated that sFLC measurement accurately differentiated IgM-MGUS compared with WM reflecting a measurement of tumor burden. In univariate and multivariate analysis, median sFLC at the cut-off at 60 mg/L was higher for WM patients with low hemoglobin and high beta2M, when we applied the WM-IPSS cut-offs, but showed no association with IgM level. This study demonstrates that sFLC is a new marker in WM disease. Further analysis is required to prospectively study the role of sFLC in monitoring response to therapy and as a prognostic marker in WM patients.
Leleu
Xavier
X
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA 02115, USA.
Moreau
Anne-Sophie
AS
Weller
Edie
E
Roccaro
Aldo M
AM
Coiteux
ValéRie
V
Manning
Robert
R
Nelson
Marybeth
M
Leduc
Renee
R
Robu
Daniela
D
Dupire
Sophie
S
Hatjiharissi
Evdoxia
E
Burwick
Nicholas
N
Darre
Stéphane
S
Hennache
Bernadette
B
Treon
Steven P
SP
Facon
Thierry
T
Gertz
Morie A
MA
Ghobrial
Irene M
IM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007390:International Agencies; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000276:immunology; D011379:Prognosis; D015996:Survival Rate; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000097:blood / Q000276:immunology
D014408:Biomarkers, Tumor; D006454:Hemoglobins; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D001613:beta 2-Microglobulin