title: The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors.
abstract: BACKGROUND
  Thrombocytosis has been reported in a variety of solid tumors, including certain gynecologic cancers such as endometrial, vulvar, and cervical cancers. The present study aims to determine the incidence of thrombocytosis in women with epithelial ovarian tumors and to evaluate its association with clinical and pathologic prognostic factors.
  
  
  METHODS
  Between January 2001 and December 2006, 292 patients were diagnosed with epithelial ovarian tumors, and they underwent primary surgical treatment and subsequent platinum-based chemotherapy at the Gynecologic Oncology Department of the study center. The medical records of these patients were evaluated retrospectively.
  
  
  RESULTS
  Of the 292 women with epithelial ovarian tumors undergoing primary surgical exploration, 124 (42.5%) had thrombocytosis, indicating platelet counts >400 x 10(9)/l. Patients with thrombocytosis were found to have statistically higher levels of preoperative CA-125 levels, more advanced stage disease, higher grade tumors, and shorter periods of survival. Thrombocytosis is a significant negative prognostic factor for survival in patients with epithelial ovarian tumors.
  
  
  CONCLUSIONS
  Thrombocytosis is frequently detected in preoperative evaluation of women diagnosed with epithelial ovarian tumors. The data obtained by the previous and present studies suggest that thrombocytosis is associated with factors reflecting a more aggressive tumor biology, and predicting poor survival in women with epithelial ovarian tumors. However, these data are limited by the retrospective nature of the studies and do not confirm a casual relationship between thrombocytosis and tumor behavior. Molecular studies investigating the expression of platelet secretory factors are required to clarify the differences among data provided by the literature.
authors.affiliation: Department of Gynecologic Oncology, Dr Zekai Tahir Burak Women Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
authors.forename: Mine
authors.initials: M
authors.lastname: Kanat-Pektas
authors.forename: Ayhan
authors.initials: A
authors.lastname: Sucak
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D018394:CA-125 Antigen / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D010976:Platelet Count; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013922:Thrombocytosis / Q000097:blood / Q000473:pathology*
chemical_list: D018394:CA-125 Antigen; D006454:Hemoglobins