title: Oxidative stress, inflammation, and atherosclerotic changes in retinal arteries in the Japanese population; results from the Mima study.
abstract: Oxidative stress and inflammation are known to play roles in the pathogenesis of vascular events. The aim of this study was to investigate the relationship between oxidative stress, inflammation, and atherosclerosis in the general population. A population-based, cross-sectional study was made of 282 people (126 men and 156 women, mean age; 65 13, mean BMI; 25.4 2.7 kg/m (2) ) recruited from the Mima study in Tokushima Prefecture. Risk factors included age, sex, body mass index (BMI), cigarette smoking, systolic and diastolic pressure, fasting blood glucose, serum lipids, and high-sensitive C-reactive protein (hs-CRP). Oxidative stress in blood samples was measured by the diacron reactive oxygen metabolites (ROMs) test. The degree of sclerotic change was determined from fundus photographs according to Scheie's classification. After adjustment for age and sex, ROM levels positively correlated with hs-CRP levels, but not with ghrelin, leptin and adiponectin levels. Furthermore, ROM and hs-CRP levels positively and individually correlated with the grade of sclerotic change in the fundus oculi independent of age in a multiple regression analysis. These results suggest that oxidative stress and chronic inflammation promote atherosclerosis in the retinal arteries in the general population.
authors.affiliation: Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakane
authors.forename: Shinji
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sano
authors.forename: Masayuki
authors.initials: M
authors.lastname: Domichi
authors.forename: Kokoro
authors.initials: K
authors.lastname: Tsuzaki
authors.forename: Yukiyo
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Taku
authors.initials: T
authors.lastname: Hamada
authors.forename: Kyoko
authors.initials: K
authors.lastname: Saiga
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001167:Arteritis / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011153:Population; D017382:Reactive Oxygen Species / Q000097:blood / Q000378:metabolism; D012161:Retinal Artery / Q000473:pathology*; D012164:Retinal Diseases / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors
chemical_list: D017382:Reactive Oxygen Species; D002097:C-Reactive Protein