Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes.
The level of natural apoptosis in rat thymus on day 18 of embryo development attained 25%, while at subsequent terms it was about 5%. In the spleen, this parameter gradually decreased from 15 to 37% starting from day 18 of embryo development to postnatal day 30. Tactivin prevented the development of dexamethasone-induced apoptosis in thymocytes of 30-day-old rats, but had no effect on spontaneous apoptosis. Tactivin can be used as a modulator of apoptotic processes.
Arion
V Y
VY
N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Science.
Mel'nikova
V I
VI
Afanas'eva
M A
MA
Moskvina
S N
SN
Zakharova
L A
LA
D000276:Adjuvants, Immunologic / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D003907:Dexamethasone / Q000633:toxicity*; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013949:Thymus Extracts / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D003907:Dexamethasone; C036191:T-activin