Developments towards tissue-engineered, small-diameter arterial substitutes.
This article reviews the present state of small-diameter vascular substitution, the mechanisms of graft failure and the ongoing matters of graft design, with particular attention to small-caliber grafts. Tissue engineering of blood vessels with the mechanical properties of native vessels and with the antithrombotic properties required is really a great challenge. Recent advances, however, indicate that the goal of providing a tissue-engineered vascular graft that will remain patent in vivo for substantial periods of time, is achievable. This review describes the specific requirements of the successful replacement artery from a biomaterial- and tissue-engineering perspective, as well as various approaches in vascular tissue engineering including cells and cell sources, scaffolds and their improvements as well as bioreactors and signaling.
Bordenave
Laurence
L
CHU de Bordeaux, Pessac, France. laurence.bordenave@u-bordeaux2.fr
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Patrick
P
Baquey
Charles
C
D001158:Arteries; D001807:Blood Vessel Prosthesis / Q000639:trends*; D006801:Humans; D023822:Tissue Engineering / Q000639:trends*