Preparation and evaluation of inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites: performance and substantivity studies.
Herein we describe inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites to generate new sunscreen derivatives with optimized functional properties such as water resistance and skin adherence. Four cyclodextrins (alpha-, beta-, and gamma-cyclodextrin, and beta-dimethyl cyclodextrin) and two montmorillonites (sodium and alkylammonium) were investigated for encapsulating some commercial sunscreens. Our results reveal a good yield and inclusion products with functional properties obtained by using kneading technique on Eusolex 2292 and Eusolex 6007 in beta-cyclodextrin and solubilization method on Eusolex 6007 and NeoHeliopan MA in montmorillonite. In addition, molecular modeling studies indicated flexibility as important for the intercalation of the host molecule.
Coelho
Genoveva Luciana Negve
GL
Departamento de Medicamentos, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Dornelas
Camila Braga
CB
Soares
Kelen Carine Costa
KC
dos Santos
Elisabete Pereira
EP
Vergnanini
André L
AL
dos Santos
Tereza Cristina
TC
Rodrigues
Carlos Rangel
CR
Castro
Helena Carla
HC
Dias
Luiza R S
LR
Cabral
Lúcio Mendes
LM
D000818:Animals; D001546:Bentonite / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D004355:Drug Stability; D005123:Eye / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D009883:Ophthalmic Solutions; D011817:Rabbits; D023422:Skin Irritancy Tests; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013473:Sunscreening Agents / Q000737:chemistry* / Q000633:toxicity; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
D003505:Cyclodextrins; D004337:Drug Carriers; D009883:Ophthalmic Solutions; D013473:Sunscreening Agents; D001546:Bentonite