title: Detection of human papillomavirus type 11 in a case of Buschke-Löwenstein tumor.
abstract: We here report a 31-year-old male affected by a papillary tumor in his pubic region. At 26 years of age, he consulted a nearby clinic and was prescribed a topical cream. Although the condition was not relieved, he left the disease untreated. The gradually growing tumor adversely affected his quality of life, and he consulted another clinic, where he was referred to our hospital for surgery. The tumor had infiltrated the tissue at the base of the penis, but not the glans. After careful examination, we performed local excision of the tumor and a split-thickness skin graft. On pathological examination, elongation of the epidermis and koilocytes in the uppermost portion of the spinous layer were observed. Moreover, PCR examination confirmed the presence of human papillomavirus (HPV) type 11 in the tumor tissue. These findings supported a diagnosis of Buschke-Löwenstein tumor (BLT).
authors.affiliation: Division of Dermatology, Department of Medicine, University of the Ryukyu, 207 Uehara, Nishiara town, Okinawa, Japan. yasatoy@med.u-ryukyu.ac.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Asato
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Taira
authors.forename: Yu-Ichi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uezato
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000821:virology*; D018289:Carcinoma, Verrucous / Q000175:diagnosis / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D052140:Human papillomavirus 11 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis; D010412:Penile Neoplasms / Q000175:diagnosis / Q000821:virology*; D010413:Penis / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral