Enantioselective Baeyer-Villiger oxidation catalyzed by palladium(II) complexes with chiral P,N-ligands.
Asymmetric Baeyer-Villiger reaction of symmetrical cyclobutanones 1a-j with urea-hydrogen peroxide (UHP) can be catalyzed by a complex of Pd(II) and the new terpene-derived P, N-ligand 7. The resulting lactones 2a-j were obtained in high yields and with good enantioselectivity (< or =81% ee).
Malkov
Andrei V
AV
Department of Chemistry, WestChem, University of Glasgow, Glasgow, Scotland, U.K. amalkov@chem.gla.ac.uk
Friscourt
Frédéric
F
Bell
Mark
M
Swarbrick
Martin E
ME
Kocovský
Pavel
P
D002384:Catalysis; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D008024:Ligands; D010165:Palladium