title: [Effect of obesity on bone metabolism].
abstract: Obesity regulates bone metabolism not only by increasing weight loading but by modulating cytokines or hormones which are known to affect bone remodeling. As a result, it has been generally believed that obesity leads to an increase in bone mass. However, recent observations revealed that excessive fat mass may not protect against osteoporotic fractures.
authors.affiliation: Tokyo Medical and Dental University Graduate School, Department of Orthopedics.
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation; D004038:Diet, Reducing / Q000009:adverse effects; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D020738:Leptin / Q000378:metabolism / Q000502:physiology; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D010006:Osteoblasts / Q000166:cytology; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism; D012306:Risk
chemical_list: D020738:Leptin