Dicarbonyls stimulate cellular protection systems in primary rat hepatocytes and show anti-inflammatory properties.
Advanced glycation endproducts (AGEs) and their precursor dicarbonyls are generally perceived as having adverse health effects. They are also considered to be initiators and promoters of disease and aging. However, proof for a causal relationship is lacking. On the other hand, it is known that AGEs and melanoidins possess beneficial properties, such as antioxidant and metal-chelating activities. Furthermore, some AGEs may stimulate the cellular detoxification system, generally known as the phase II drug metabolizing system. We show here that several reactive dicarbonyl intermediates have the capability to stimulate the cellular phase II detoxification systems in both a reporter cell line and primary rat hepatocytes. In addition, we demonstrate that dicarbonyls can attenuate the inflammatory signaling induced by tumor necrosis factor-alpha in a reporter cell system.
Buetler
Timo M
TM
Nestlé Research Center, Lausanne 26, Switzerland. Timo.Buetler@rdls.nestle.com
Latado
Hélia
H
Baumeyer
Alexandra
A
Delatour
Thierry
T
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D017127:Glycation End Products, Advanced / Q000494:pharmacology*; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006873:Hydroquinones / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D012313:RNA / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D035181:TATA-Box Binding Protein / Q000235:genetics
D000893:Anti-Inflammatory Agents; D017127:Glycation End Products, Advanced; D006873:Hydroquinones; D012333:RNA, Messenger; D035181:TATA-Box Binding Protein; D012313:RNA; C018855:2-tert-butylhydroquinone