title: Boronated pyrimidines and purines as cytotoxic, hypolipidemic and anti-inflammatory agents.
abstract: The simple boronated bases, e.g. cytosine, adenine and guanine, containing no sugar residues retained good pharmacological activity as hypolipidemic, anti-neoplastic and anti-inflammatory agents in mice at 8 mg/kg. Their activities were generally identical to their respective nucleoside derivatives. Interestingly the boronated acyclovir derivative was a very potent hypolipidemic agent achieving better activity than clofibrate and lovastatin. The boronated adenine derivatives appeared to have the best anti-inflammatory activity in reducing local edema and analgesic effects. The agents were active against the growth of murine and human leukemias and human HeLa-S(3) suspended uterine carcinoma. Only the boronated adenine derivatives were effective in blocking the growth of human SW480 adenocarcinoma and the KB nasopharynx.
authors.affiliation: Division of Medicinal Chemistry and Natural Products School of Pharmacy University of North Carolina Chapel Hill North Carolina 27599-7360 USA.
authors.forename: I H
authors.initials: IH
authors.lastname: Hall
authors.forename: B S
authors.initials: BS
authors.lastname: Burnham
authors.forename: A
authors.initials: A
authors.lastname: Elkins
authors.forename: A
authors.initials: A
authors.lastname: Sood
authors.forename: W
authors.initials: W
authors.lastname: Powell
authors.forename: J
authors.initials: J
authors.lastname: Tomasz
authors.forename: B F
authors.initials: BF
authors.lastname: Spielvogel