title: Condensed and hydrolysable tannins as antioxidants influencing the health.
abstract: Natural polyphenols are a wide class of secondary plant metabolites and represent an abundant antioxidant component of human diet. An important, but often neglected group of natural polyphenols, are tannins. This review offers a general description of chemistry of both hydrolysable and condensed tannins (proanthocyanidins), the mechanisms of their antioxidation action, like free radical scavenging activity, chelation of transition metals, inhibition of prooxidative enzymes and lipid peroxidation. The mechanisms of action of antibacterial, antiviral, anticarcinogenic, cardiovascular system preventing, and antiinflammatory effects as well as the absorption, metabolic fate and positive in vivo effects of tannins are enclosed.
authors.affiliation: Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
authors.forename: Vit
authors.initials: V
authors.lastname: Koleckar
authors.forename: Katerina
authors.initials: K
authors.lastname: Kubikova
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Rehakova
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
authors.forename: Ludek
authors.initials: L
authors.lastname: Jahodar
authors.forename: Lubomir
authors.initials: L
authors.lastname: Opletal
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006262:Health; D006735:Horseradish Peroxidase / Q000037:antagonists & inhibitors; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008084:Lipoxygenase / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D047348:Hydrolyzable Tannins; D006735:Horseradish Peroxidase; D008084:Lipoxygenase; D019001:Nitric Oxide Synthase