A new elemanolide sesquiterpene lactone from Elephantopus scaber.
A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC(50) 8.18-14.08 micromol/l).
Liang
Qiao-Li
QL
Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, China.
Min
Zhi-Da
ZD
Tang
Yu-Ping
YP
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D045788:Sesquiterpenes, Germacrane / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C528427:deoxyelephantopin; C531131:elescaberin