Biological effects induced by nanosilver particles: in vivo study.
Nanosilver particles and microsilver particles were implanted into a rat's back muscle. The pathology and the local biocompatibility were observed and compared at days 7, 14, 30, 90 and 180 after implantation. A good biological effect was observed on days 7 and 14, both in rats treated with nanosilver particles and in rats treated with microsilver particles. A bad biological effect was observed at day 30, and the nanosilver-treated rats had more serious inflammation than the microsilver-treated rats.
Chen
Dandan
D
National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People's Republic of China.
Xi
Tingfei
T
Bai
Jing
J
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry; D008422:Materials Testing; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000008:administration & dosage* / Q000737:chemistry*
D001672:Biocompatible Materials; D012834:Silver