Gastrointestinal stromal tumors.
Gastrointestinal stromal tumors (GIST) are rare neoplasias, but they represent the most common non-epithelial (mesenchymal) tumor of the digestive tract. GISTs originate in an intestinal pacemaker cell called the intestinal cell of Cajal and express the cell-surface receptor KIT (CD117). They were first defined as a separate category in 1983, and since then important data regarding their clinical behavior, histopathological particularities, immunohistopathology, molecular biology and therapeutic possibilities were reported. In this article we aim to present a review of the information concerning this subject available in the medical literature at the moment.
Popescu
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I
Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania. irinel.popescu@icfundeni.ro
Andrei
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S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics; D003937:Diagnosis, Differential; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen / Q000276:immunology; D017354:Point Mutation; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019009:Proto-Oncogene Proteins c-kit