Future target molecules for influenza treatment.
Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.
Uchide
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N
Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. uchide@ps.toyaku.ac.jp
Toyoda
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H
D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D009637:Masoprocol / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013481:Superoxides / Q000037:antagonists & inhibitors; D013859:Thiocarbamates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D016207:Cytokines; D011759:Pyrrolidines; D013859:Thiocarbamates; D013481:Superoxides; C020972:pyrrolidine dithiocarbamic acid; D009637:Masoprocol