title: Arginine methylation of hnRNP K enhances p53 transcriptional activity.
abstract: Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.
authors.affiliation: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Chen
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Chaochen
authors.initials: C
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Mo
authors.forename: Gengxi
authors.initials: G
authors.lastname: Hu
mesh_terms: D001120:Arginine / Q000378:metabolism*; D002460:Cell Line; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D034641:Heterogeneous-Nuclear Ribonucleoprotein K / Q000378:metabolism* / Q000528:radiation effects; D006801:Humans; D008745:Methylation; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53; D001120:Arginine