title: The impact of waist-to-hip ratio on clinical outcomes in metastatic breast cancer patients treated with aromatase inhibitors.
abstract: We aimed to identify whether abdominal fat distribution could affect the outcome in metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs) or not. A total of 42 MBC patients treated with first line hormonal therapy were enrolled in this study. Factors associated with overall survival in the univariate analysis were age, c-erb-B2 expression intensity (+++ versus others by immunohistochemistry), and WHR, whereas only WHR retained significance in the multivariate analysis. Median overall survival figures were 472 days versus unreached for patients with a WHR of <0.92 and >or=0.92 (Log rank statistic=9.76, P=0.002). Similarly, the corresponding progression free survival figures for patients with a WHR of <0.92 and >or=0.92 were 423 versus 1004 days (Log rank statistic=6.37, P=0.012). This study suggests that WHR may serve as a potential predictive marker in MBC patients treated with AIs.
authors.affiliation: Division of Medical Oncology, Meram Medical Faculty, Selcuk University, Konya, Turkey. martac@selcuk.edu.tr
authors.forename: Mehmet
authors.initials: M
authors.lastname: Artac
authors.forename: Hakan
authors.initials: H
authors.lastname: Bozcuk
authors.forename: Berna
authors.initials: B
authors.lastname: Afacan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozdogan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Samur
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D000368:Aged; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D050218:Body Fat Distribution; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D015996:Survival Rate; D049629:Waist-Hip Ratio
chemical_list: D047072:Aromatase Inhibitors