[Advance in study of induced pluripotent stem cells (iPS cells)].
By retroviral transduction of four or three transcription factors, mouse and human somatic cells have been reprogrammed to an undifferentiated state similar to embryonic stem (ES) cells, and these cells have been termed induced pluripotent stem (iPS) cells. This technology has opened the avenue to generate patient- and disease-specific pluripotent stem cells, which are useful for not only customized cell transplantation therapy without rejection but also for understanding disease mechanisms, drug screening and toxicology. In this review, we discuss the overview of the advance of iPS cells.
Aoi
Takayuki
T
Department of Stem Cell Biology, Institute of Frontier Medical Sciences, Kyoto University.
D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D053595:Embryonic Stem Cells; D005822:Genetic Vectors; D006801:Humans; D008099:Liver / Q000166:cytology; D051379:Mice; D039904:Pluripotent Stem Cells; D012190:Retroviridae; D033581:Stem Cell Transplantation; D013270:Stomach / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics; D014161:Transduction, Genetic
D014157:Transcription Factors