title: Diarrheic syndrome as a clinical sign of intestinal infiltration in progressive B-cell chronic lymphocytic leukemia.
abstract: Gastrointestinal involvement is a rare event in patients with B-cell chronic lymphocytic leukemia (B-CLL) and is usually associated to lymphomatous transformation. However, in autopsy studies the reported incidence of microscopic infiltration can reach up to 50% of cases. Seven B-CLL patients in advanced stage/progressive disease were evaluated by colonoscopy because of continuous diarrhea. Five out of seven patients (71%) presented histological evidence of colonic infiltration. Persistent diarrhea in patients with progressive/advanced B-CLL can be a clinical sign of intestinal infiltration and justifies endoscopic examinations.
authors.affiliation: Department of Clinical Hematology, Spain. 92724@imas.imim.es
authors.forename: E
authors.initials: E
authors.lastname: Abella
authors.forename: T
authors.initials: T
authors.lastname: Gimenez
authors.forename: J
authors.initials: J
authors.lastname: Gimeno
authors.forename: M
authors.initials: M
authors.lastname: Cervera
authors.forename: C
authors.initials: C
authors.lastname: Pedro
authors.forename: E
authors.initials: E
authors.lastname: Gimeno
authors.forename: A
authors.initials: A
authors.lastname: Alvarez
authors.forename: A
authors.initials: A
authors.lastname: Salar
authors.forename: B
authors.initials: B
authors.lastname: Bellosillo
authors.forename: S
authors.initials: S
authors.lastname: Serrano
authors.forename: C
authors.initials: C
authors.lastname: Besses
mesh_terms: D002908:Chronic Disease; D003967:Diarrhea / Q000150:complications*; D006801:Humans; D007414:Intestinal Neoplasms / Q000556:secondary*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology