Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles.
Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an SN2' substitution followed by a subsequent cycloisomerization step.
Chernyak
Dmitri
D
Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061, USA.
Gadamsetty
Surendra Babu
SB
Gevorgyan
Vladimir
V
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007536:Isomerism; D009584:Nitrogen / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013696:Temperature
D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D003300:Copper; D009584:Nitrogen