title: Fluorinated analogs of malachite green: synthesis and toxicity.
abstract: A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.
authors.affiliation: Iowa State University Department of Chemistry, Ames, IA 50011, USA. gakraus@iastate.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Kraus
authors.forename: Insik
authors.initials: I
authors.lastname: Jeon
authors.forename: Marit
authors.initials: M
authors.lastname: Nilsen-Hamilton
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Awad
authors.forename: Jayeeta
authors.initials: J
authors.lastname: Banerjee
authors.forename: Bahram
authors.initials: B
authors.lastname: Parvin
mesh_terms: D002460:Cell Line; D005461:Fluorine / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D012394:Rosaniline Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013057:Spectrum Analysis
chemical_list: D012394:Rosaniline Dyes; C005095:malachite green; D005461:Fluorine