title: Zebrafish as a new animal model for movement disorders.
abstract: The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high throughput in vivo drug screening.
authors.affiliation: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Flinn
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bretaud
authors.forename: Christine
authors.initials: C
authors.lastname: Lo
authors.forename: Phillip W
authors.initials: PW
authors.lastname: Ingham
authors.forename: Oliver
authors.initials: O
authors.lastname: Bandmann
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006816:Huntington Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D009069:Movement Disorders / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D015027:Zebrafish / Q000235:genetics* / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents