title: Stereotactic disconnection of hypothalamic hamartoma to control seizure and behavior disturbance: case report and literature review.
abstract: An 18-year-old boy with refractory epilepsy and aggressiveness associated to a hypothalamic hamartoma was submitted to a stereotactically guided lesion by thermocoagulation. The target was based on magnetic resonance (MR) images merged with computed tomography scan images taken on the day of surgery while patient was on a stereotactic frame. In order to reveal structures not discernible in MR images, the Schaltenbrand digital brain atlas was merged onto the patient's images. Target and trajectory of the depth electrode were chosen based on three-dimensional imaging reconstructions. A surgical plan was devised to disconnect the hypothalamic hamartoma from the hypothalamus, medial forebrain bundle, fasciculus princeps, and dorsal longitudinal fasciculus. Our target was placed at the inferior portion of the posterolateral component of the hamartoma, bordering the normal hypothalamus. The patient evolved with marked lessening of aggressiveness. Seizure frequency was reduced from several seizures per day to less than one tonic-clonic seizure during sleep per month and only two episodes suggestive of partial complex seizures during daytime. These results have remained consistent over a 24-month postoperative follow-up. Functional neuroanatomy of hypothalamic connections involved in seizure propagation and aggressive behavior was reviewed.
authors.affiliation: Departamento de Neurologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. almeidaan@globo.com
authors.forename: Antonio Nogueira
authors.initials: AN
authors.lastname: de Almeida
authors.forename: Erich Talamoni
authors.initials: ET
authors.lastname: Fonoff
authors.forename: Gerson
authors.initials: G
authors.lastname: Ballester
authors.forename: Manoel Jacobsen
authors.initials: MJ
authors.lastname: Teixeira
authors.forename: Raul
authors.initials: R
authors.lastname: Marino
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D004351:Drug Resistance; D004567:Electrodes, Implanted; D004569:Electroencephalography; D006222:Hamartoma / Q000150:complications / Q000523:psychology / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000523:psychology / Q000601:surgery*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000209:etiology / Q000517:prevention & control*; D019635:Neurosurgical Procedures; D016634:Radiosurgery; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000927:Anticonvulsants