title: [Colonization of Candida species and efficacy of miconazole gel in overdenture wearers].
abstract: OBJECTIVE
  Preliminarily to examine the efficacy of miconazole gel at inhibiting colonization of Candida species in overdenture wearers.
  
  
  METHODS
  The subjects were 26 overdenture wearers. Miconazole gel was used with the following directions: group A was prescribed miconazole gel 1.5 g 4 times daily for 1 week, group B was prescribed miconazole gel 0.5 g 4 times daily for 1 week. As a screening test, Candida species were examined in denture plaque, dental plaque, and pharyngeal mucosa. The number of Candida species, total bacteria, and oral streptococci were counted before and after application of miconazole gel to Candida-positive subjects.
  
  
  RESULTS
  Candida species were detected in 18 of 26 subjects and high incidence was found around the abutments under the denture base. All Candida species were sensitive to miconazole gel. Miconazole gel was applied to 13 subjects. The number of Candida was reduced after 1-week use of miconazole gel with few side effects during the application.
  
  
  CONCLUSIONS
  It is suggested that miconazole gel will be an effective and safe method for oral care and denture plaque control in overdenture wearers.
authors.affiliation: Department of Oral and Maxillofacial Prosthodontics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yoshijima
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ichikawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control*; D003828:Denture, Overlay / Q000382:microbiology*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology*; D014070:Tooth / Q000382:microbiology*
chemical_list: D005782:Gels; D008825:Miconazole