Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis.
During the study of anti-HIV-1 active components of the aqueous extracts of the roots of Salvia yunnanensis, three new derivatives of polyphenols, namely: methyl salvianolate A (2), ethyl salvianolate A (3) and cis-lithospermic acid (5) were isolated along with two known polyphenols, salvianolic acid A (1) and lithospermic acid (4) their structures were elucidated on the basis of NMR and MS spectral analyses. The anti-HIV-1 activities of the 5 polyphenols were tested for the inhibition of P24 antigen in HIV-1 infected MT-4 cell cultures and HIV-1 replicative enzymes in vitro.
Zhang
Zheng-Fu
ZF
Chinese Academy of Medical Sciences, Institute of Medicinal Biotechnology, Beijing, China.
Peng
Zong-Gen
ZG
Gao
Lei
L
Dong
Biao
B
Li
Jian-Rui
JR
Li
Zhuo-Yong
ZY
Chen
Hong-Shan
HS
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016655:HIV Core Protein p24 / Q000037:antagonists & inhibitors*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006801:Humans; D007773:Lactates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D027544:Salvia / Q000737:chemistry*
D019380:Anti-HIV Agents; D001572:Benzofurans; D002109:Caffeic Acids; D053630:Depsides; D016655:HIV Core Protein p24; D007773:Lactates; D010936:Plant Extracts; D018894:Reverse Transcriptase Inhibitors; C046833:lithospermic acid; C066201:salvianolic acid A; D054303:HIV Reverse Transcriptase