[Effects of antiosteoporotic agents on glucose and lipid metabolism and cardiovascular system].
Cardiovascular disease is the main contributor of mortality among postmenopausal women. Hormone Replacement Therapy (HRT) has been reported to have a beneficial effect on metabolic and vascular factors. Although, randomized clinical trials have questioned the efficacy of HRT in primary and secondary coronary artery disease (CAD) prevention despite confirming the lipid-lowering effect of HRT. As for selective estrogen receptor modulators (SERMs) , the available information suggests a neutral balance on CAD and stroke, and an increase in risk similar to estrogens for venous thromboembolic diseases. Evidence from both basic science and clinical studies supports the protective role of vitamin D beyond its effect on mineral metabolism. Recent studies suggest that Vitamin D improves vascular compliance, and reduces pro-inflammatory cytokines which may contribute to the improved survival observed in retrospective studies examining the outcome of patients treated with activated Vitamin D compared to those who were not.
Fukai
Shiho
S
The University of Tokyo, Graduate School of Medicine, Department of Geriatric Medicine.
D001161:Arteriosclerosis / Q000517:prevention & control; D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000517:prevention & control; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D012306:Risk; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects; D020246:Venous Thrombosis / Q000209:etiology; D014807:Vitamin D / Q000494:pharmacology* / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D020845:Selective Estrogen Receptor Modulators; D014807:Vitamin D; D005947:Glucose