title: Influences of perinatal dioxin load to visual motion and oddball stimuli examined with an EEG and MEG analysis.
abstract: OBJECTIVE
  With MEG and EEG the effect of perinatal dioxin load of 38 healthy 7- to 12-year-old children was studied to assess possible disturbances of visual development.
  
  
  METHODS
  Latencies and amplitudes of the motion (N2 with subcomponents) and oddball responses (N200 and P3b) were analysed after age correction.
  
  
  RESULTS
  With increasing load, latencies increased and the amplitudes of the oddball components tended to be reduced. The latency increase between the high- and low-loaded children was about 13 ms (P<0.004) and the oddball response showed an amplitude decrease of 12% (P=0.009).
  
  
  CONCLUSIONS
  It may be concluded that, during the end-80s/early-90s, exposure to background levels in industrialized regions seems to have resulted in small underdevelopment or damage to visual motion processing and visual cognition.
  
  
  CONCLUSIONS
  Since dioxin pollution by incinerators still exists in many regions in developing countries and also still, although at a smaller scale, in the industrialized world, perinatal loads of similar magnitude and possibly more as measured in this study may occur and as a consequence might affect the developing brain.
authors.affiliation: Department of Medical Physics, Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands. N.A.Schellart@amc.uva.nl
authors.forename: Nico A M
authors.initials: NA
authors.lastname: Schellart
authors.forename: Dik
authors.initials: D
authors.lastname: Reits
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000375:Aging / Q000523:psychology; D002648:Child; D003864:Depression, Chemical; D002658:Developmental Disabilities / Q000139:chemically induced* / Q000517:prevention & control*; D004147:Dioxins / Q000032:analysis / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D015225:Magnetoencephalography / Q000187:drug effects*; D008297:Male; D009039:Motion Perception / Q000187:drug effects*; D009426:Netherlands; D010775:Photic Stimulation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D011597:Psychomotor Performance / Q000187:drug effects*; D012016:Reference Values; D015348:Vision, Binocular / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants