Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development.
The mechanism of interaction of hypochlorite and hypobromite formed in myeloperoxidase catalysis with lipids of human blood low-density lipoprotein is described. Both agents react with unsaturated lipids via two mechanisms: molecular (with the formation of mainly chloro- or bromohydrins and lysophospholipids) and free-radical (paralleled by lipid peroxidation). These reactions modify physicochemical properties of low-density lipoproteins and disorder their lipid-transporting function thus initiating early stages of atherosclerosis development.
Panasenko
O M
OM
Laboratory of Physicochemical Methods of Research and Analysis, Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow. oleg-panasenko@newmail.ru
Vakhrusheva
T V
TV
Vlasova
I I
II
Chekanov
A V
AV
Baranov
Y V
YV
Sergienko
V I
VI
D050197:Atherosclerosis / Q000097:blood*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D009195:Peroxidase / Q000378:metabolism*
D005609:Free Radicals; D008077:Lipoproteins, LDL; D009195:Peroxidase