title: Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response.
abstract: In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both ex vivo induced antigen-specific proliferation as well as production of proinflammatory cytokines by splenocytes were higher in IL-10 KO mice than in WT mice. Also, intrapulmonary proinflammatory cytokine levels were higher in IL-10 KO mice than in the WT mice. The lack of anti-inflammatory action of IL-10 is likely to contribute to the enhanced clearance but severe inflammation in this experimental model.
authors.affiliation: Department of Virology, Haartman Institute, University of Helsinki, Finland.
authors.forename: Tuula
authors.initials: T
authors.lastname: Penttilä
authors.forename: Anu
authors.initials: A
authors.lastname: Haveri
authors.forename: Anne
authors.initials: A
authors.lastname: Tammiruusu
authors.forename: Jenni M
authors.initials: JM
authors.lastname: Vuola
authors.forename: Riitta
authors.initials: R
authors.lastname: Lahesmaa
authors.forename: Mirja
authors.initials: M
authors.lastname: Puolakkainen
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002690:Chlamydia Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D016993:Chlamydophila pneumoniae / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D016207:Cytokines; D016753:Interleukin-10