[Kidney regeneration update].
Functional recovery in acute renal failure is well known, and the adult kidney is generally recognized to have the capacity to regenerate and repair. Several groups have reported the contribution of bone marrow-derived cells in this process, and others have confirmed the existence of adult stem cells in the kidney, including label retaining cells, slow-cycling cells, side population cells, and rKS506 cells. However, recent data demonstrated that in vivo differentiation of bone marrow-derived cells into renal tubular cells may not occur at all, or is at most a minor component of the repair process. Moreover, it is now generally accepted that stem cells and multipotent cells contribute to the regenerative process by producing protective and regenerative factors rather than by directly differentiating to replace damaged cells. This review will focus on current understanding of kidney regeneration.
Hishikawa
Keiichi
K
Division of Nephrology and Endocrinology, Department of Internal Medicine and Clinical Renal Regeneration, University of Tokyo.
Fujita
Toshiro
T
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D001854:Bone Marrow Cells / Q000166:cytology; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation; D049109:Cell Proliferation; D015195:Drug Design; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D007668:Kidney / Q000166:cytology* / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000037:antagonists & inhibitors; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology
D051792:Basic Helix-Loop-Helix Proteins; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C525819:BMP7 protein, human; C117673:Msc protein, mouse; C012589:trichostatin A