title: Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients.
abstract: It is hypothesized that molecular components of dopaminergic system, especially the dopamine D3 receptor gene (DRD3), may play a crucial role in the pathophysiology of schizophrenia, because it is abundant in the limbic system of the brain and it binds antipsychotic drugs. Several groups attempted to find an association between a serine-to-glycine polymorphism of the DRD3 gene (Ser9Gly) and schizophrenia; however, the results were inconsistent. In this study, we aimed to investigate the relationship of the Serine/Glycine polymorphism of the DRD3 gene with therapeutic response to clozapine treatment between Turkish schizophrenia patients (N = 92) and healthy controls (N = 100). Genotype groups were comparable in BPRS, SAPS, SANS analysis of response to clozapine. Our results suggest that an association between the Ser/Gly polymorphism of DRD3 gene and response to clozapine in Turkish schizophrenia patients is unlikely to exist.
authors.affiliation: Department of Medical Biology and Genetics, Medical Faculty of Mersin University, Turkey. iobarlas@gmail.com
authors.forename: I Omer
authors.initials: IO
authors.lastname: Barlas
authors.forename: Mesut
authors.initials: M
authors.lastname: Cetin
authors.forename: M Emin
authors.initials: ME
authors.lastname: Erdal
authors.forename: Umit B
authors.initials: UB
authors.lastname: Semiz
authors.forename: Cengiz
authors.initials: C
authors.lastname: Basoglu
authors.forename: M Ertan
authors.initials: ME
authors.lastname: Ay
authors.forename: Hasan
authors.initials: H
authors.lastname: Herken
authors.forename: Ozcan
authors.initials: O
authors.lastname: Uzun
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001483:Base Sequence; D016022:Case-Control Studies; D003024:Clozapine / Q000627:therapeutic use*; D017931:DNA Primers; D005998:Glycine / Q000235:genetics*; D011110:Polymorphism, Genetic; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics; D012694:Serine / Q000235:genetics*; D014421:Turkey
chemical_list: D014150:Antipsychotic Agents; D017931:DNA Primers; C493593:DRD3 protein, human; D050637:Receptors, Dopamine D3; D012694:Serine; D003024:Clozapine; D005998:Glycine