title: Enrofloxacin-imprinted monolithic columns synthesized using reversible addition-fragmentation chain transfer polymerization.
abstract: Molecularly imprinted monolithic columns for selective separation of enrofloxacin were prepared by Reversible Addition-Fragmentation Chain Transfer (RAFT)-mediated radical polymerization. Different ratios of initiation system were used in the synthesis. The structures of the monoliths were characterized to study the relationship between the synthetic conditions and morphology of the monolithic material. The separation performance of the monoliths was evaluated by liquid chromatography. Under optimized synthetic conditions, a monolithic molecularly imprinted polymer (MIP) with high selectivity and improved column efficiency was obtained. The research has shown that RAFT polymerization provides more adjustable conditions for making monolithic materials with different morphologies. The results also demonstrated that homogeneous macro-pore size distribution and large specific surface area are the key factors providing good separation ability and column efficiency for MIP monolithic structures.
authors.affiliation: College of Chemistry, Nankai University, Tianjin, China.
authors.forename: Huina
authors.initials: H
authors.lastname: Liu
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhuang
authors.forename: Mamat
authors.initials: M
authors.lastname: Turson
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Xiangchao
authors.initials: X
authors.lastname: Dong
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000097:Acetonitriles / Q000737:chemistry; D002254:Carbonates / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D007700:Kinetics; D000432:Methanol / Q000737:chemistry; D008752:Methylene Chloride / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010539:Permeability; D011108:Polymers / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D000097:Acetonitriles; D002254:Carbonates; D024841:Fluoroquinolones; D011108:Polymers; D012997:Solvents; D000077422:Enrofloxacin; D008752:Methylene Chloride; C053091:lomefloxacin; D019342:Acetic Acid; D000432:Methanol; C032159:acetonitrile