title: Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms.
abstract: The inhibitory effects on tyrosinase activity by extracts of several mushrooms belonging to Basidiomycetes were evaluated. Among the tested mushrooms (Ganoderma lucidum, Antrodia camphorata, Agaricus brasiliensis, and Cordyceps militaris), G. lucidum exhibited significant inhibition of tyrosinase activity (IC(50) value 0.32 mg/ml), compared to those prepared from other Basidiomycetes. Tyrosinase inhibitors are effective components of skin-lightening compounds and other cosmetics; currently many of the facial mask cosmetics in the market contain Ganoderma extracts in their ingredients. The finding that mushroom extracts contain tyrosinase activity inhibition will contribute to better understanding of how their 'healing' properties in various Chinese traditional herbal on skin care products.
authors.affiliation: Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Rd, Chungli, 320, Taiwan. ccchien@saturn.yzu.edu.tw
authors.forename: Chih-Ching
authors.initials: CC
authors.lastname: Chien
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Tsai
authors.forename: Chin-Chu
authors.initials: CC
authors.lastname: Chen
authors.forename: Shing-Jyh
authors.initials: SJ
authors.lastname: Chang
authors.forename: Ching-Hui
authors.initials: CH
authors.lastname: Tseng
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology*; D003358:Cosmetics / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000431:Ethanol; D005612:Freeze Drying; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D025282:Mycelium / Q000737:chemistry; D020940:Reishi / Q000737:chemistry
chemical_list: D001688:Biological Products; D003358:Cosmetics; D004791:Enzyme Inhibitors; D000431:Ethanol; D014442:Monophenol Monooxygenase