Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer.
A 27-year-old man with advanced colon cancer that was resistant to conventional chemoradiotherapies was treated with reduced-intensity allogeneic peripheral blood stem cell transplantation (PBSCT). After obtaining complete donor-type chimerism, there was an apparent graft-versus-tumor effect accompanied by severe hepatic graft-versus-host disease (GVHD) showing hyperbilirubinemia, resulting in a stable disease condition that lasted for 18 months, which had not been seen previously in his previous disease history. The antitumor effect observed in this patient was insufficient for the patient to achieve complete remission, because the disease was at an already widespread and treatment-resistant stage. He finally died of hepatic failure due to extensive liver GVHD 65 months after the diagnosis of the advanced colon cancer and 29 months after the allogeneic PBSCT. Prospective studies are necessary to achieve better clinical results in patients with advanced colon cancer.
Hashino
Satoshi
S
Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8648, Japan. shashino@med.hokudai.ac.jp
Kobayashi
Sumiko
S
Takahata
Mutsumi
M
Onozawa
Masahiro
M
Nakagawa
Masao
M
Kawamura
Takahito
T
Fujisawa
Fumie
F
Izumiyama
Koh
K
Kahata
Kaoru
K
Kondo
Takeshi
T
Asaka
Masahiro
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D000328:Adult; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D019008:Drug Resistance, Neoplasm; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D014184:Transplantation, Homologous