title: CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus.
abstract: Immune activation is a hallmark of human immunodeficiency virus type 1 (HIV-1) infection and impacts innate and adaptive immunity. Individuals coinfected with HIV-1 and hepatitis C virus (HCV) may have increased immune activation early in HIV disease because of a high HCV antigen load in tissues such as the liver. We evaluated T cell markers of activation and maturation in women with or without HIV-1 infection, by HCV antibody and HCV RNA status. We found increased percentages of activated CD8(+) T cells (i.e., CD8(+)HLA-DR(+)38(+) cells and CD8(+)CD28(+)HLA-DR(+) cells) but not of CD4(+) T cells among women who tested positive for HIV-1, HCV antibody, and HCV RNA, compared with HIV-1-positive women who tested negative for HCV antibody. Because CD8(+) T cell activation is related to HIV-1 disease progression, these data may have implications for the medical management of patients coinfected with HIV-1 and HCV.
authors.affiliation: Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, USA. akovacs@usc.edu
authors.forename: Andrea
authors.initials: A
authors.lastname: Kovacs
authors.forename: Lena
authors.initials: L
authors.lastname: Al-Harthi
authors.forename: Shawna
authors.initials: S
authors.lastname: Christensen
authors.forename: Wendy
authors.initials: W
authors.lastname: Mack
authors.forename: Mardge
authors.initials: M
authors.lastname: Cohen
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification; D006684:HLA-DR Antigens / Q000032:analysis; D016174:Hepacivirus / Q000302:isolation & purification; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology* / Q000821:virology; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology; D008562:Membrane Glycoproteins / Q000032:analysis; D012367:RNA, Viral / Q000097:blood
chemical_list: D006684:HLA-DR Antigens; D018937:Hepatitis C Antibodies; D008562:Membrane Glycoproteins; D012367:RNA, Viral; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1