[Morphology, biology and life-cycle of Plasmodium parasites].
Laveran first discovered that an infectious agent was responsible for malaria by using a simple microscope, without the assistance of specific stains. Our knowledge of the Plasmodium life cycle and cellular biology has progressed with each technological advance, from Romanovsky staining and histology to electron microscopy, immunocytochemistry, molecular methods and modern imaging techniques. The use of bird, primate and rodent models also made a major contribution, notably in the development of antimalarial drugs that are still in use today.
Hommel
Marcel
M
Institut Pasteur, 25-28, rue du Docteur Roux, 75724 Paris cedex. mhommel@pasteur.fr
D000818:Animals; D001399:Azure Stains; D001717:Birds; D009033:Culicidae / Q000469:parasitology; D004801:Eosine Yellowish-(YS); D005260:Female; D005819:Genetic Markers; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D008018:Life Cycle Stages; D008252:Macaca fascicularis; D008288:Malaria / Q000469:parasitology / Q000635:transmission / Q000662:veterinary; D008289:Malaria, Avian / Q000469:parasitology; D008297:Male; D051379:Mice; D008853:Microscopy / Q000379:methods; D008992:Monkey Diseases / Q000469:parasitology; D010961:Plasmodium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology* / Q000648:ultrastructure; D013045:Species Specificity; D014774:Virulence
D001399:Azure Stains; D005819:Genetic Markers; C046541:Romanowsky-Giemsa stain; D004801:Eosine Yellowish-(YS)