Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin.
Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.
Schirmbeck
Frederike
F
Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Georgi
Alexander
A
Strohmaier
Jana
J
Schmael
Christine
C
Boesshenz
Katja V
KV
Mühleisen
Thomas W
TW
Herms
Stefan
S
Hoffmann
Per
P
Jamra
Rami Abou
RA
Schumacher
Johannes
J
Maier
Wolfgang
W
Propping
Peter
P
Nöthen
Markus M
MM
Cichon
Sven
S
Rietschel
Marcella
M
Schulze
Thomas G
TG
D000223:Adaptation, Psychological; D000328:Adult; D017668:Age of Onset; D002352:Carrier Proteins / Q000235:genetics*; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012917:Social Adjustment
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins