Prodrugs for amines.
The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A compilation of the most important approaches is presented in the form of a table, where the main advantages and disadvantages of each strategy are also referred.
Simplício
Ana L
AL
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República - EAN, 2780-157 Oeiras, Portugal. anas@itqb.unl.pt
Clancy
John M
JM
Gilmer
John F
JF
D000588:Amines / Q000737:chemistry*; D000818:Animals; D004789:Enzyme Activation; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
D000588:Amines; D011355:Prodrugs