title: Tissue-engineered heart valve prostheses: 'state of the heart'.
abstract: In this article, we will review the current state of the art in heart valve tissue engineering. We provide an overview of mechanical and biological replacement options, outlining advantages and limitations of each option. Tissue engineering, as a field, is introduced, and specific aspects of valve tissue engineering are discussed (e.g., biomaterials, cells and bioreactors). Technological hurdles, which need to be overcome for advancement of the field, are also discussed.
authors.affiliation: Section of Cardiac Surgery, the University of Michigan, B560 Medical Science Research Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109-2110, USA.
authors.forename: Francesco
authors.initials: F
authors.lastname: Migneco
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Hollister
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Birla
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000473:pathology; D001672:Biocompatible Materials / Q000737:chemistry; D019149:Bioreactors; D042783:Endothelial Cells / Q000166:cytology; D004867:Equipment Design; D006350:Heart Valve Prosthesis; D006801:Humans; D008953:Models, Anatomic; D008954:Models, Biological; D010006:Osteoblasts / Q000166:cytology; D011108:Polymers / Q000737:chemistry; D011474:Prosthesis Design; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers