title: Effect of bone mineral with or without collagen membrane in ridge dehiscence defects following premolar extraction.
abstract: BACKGROUND
  The purpose of this investigation was to evaluate the regenerative response to deproteinized porous bovine bone mineral (BM) when used alone or in combination with a bioresorbable porcine-derived bilayer collagen membrane (CM) for alveolar ridge augmentation in dogs.
  
  
  METHODS
  The mandibular premolars were extracted unilaterally and three ridge defects were induced in six mongrel dogs. Each defect site was randomly assigned to one of the following treatment groups: BM alone (group A), BM in combination with CM (group B), or neither membrane nor bone graft, which served as a control (group C). No adverse events occurred during the experimental period. Dental computed tomography (CT) scans were taken after postoperative periods of 8 and 16 weeks.
  
  
  RESULTS
  The percentage of CT-derived bone density in groups A and B was significantly different from that of group C (p < 0.01) at 8 and 16 weeks. The percentage of CT-derived bone density of the dogs in Group B was significantly higher than that of those in group A at 8 and 16 weeks (p < 0.01). Gross evaluation of the 3-dimensional CT reconstruction image of the canine mandibles after 16 weeks of implantation showed that group B had the greatest amount of bone augmentation and excellent thickness of the buccal aspect of the alveolar ridge.
  
  
  CONCLUSIONS
  These results suggest that BM leads to more successful bone regeneration for guided bone regeneration procedures, especially in conjunction with the use of a CM as a barrier in order to promote the regeneration of canine alveolar ridge defects.
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
authors.forename: Myounghwan
authors.initials: M
authors.lastname: Kim
authors.forename: Joong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jae Yeong
authors.initials: JY
authors.lastname: Lee
authors.forename: Kirae
authors.initials: K
authors.lastname: Cho
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Gonhyung
authors.initials: G
authors.lastname: Kim
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Lee
authors.forename: Seok Hwa
authors.initials: SH
authors.lastname: Choi
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001641:Bicuspid / Q000601:surgery*; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D008297:Male; D008567:Membranes, Artificial; D013223:Statistics as Topic; D013552:Swine; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial; D003094:Collagen