Reparative reactions of the skeletal muscles in early aging OXYS rats with toxic metabolic injuries caused by bupivacaine.
Comparative analysis of reparative reactions in the anterior tibialis muscles of OXYS and Wistar rats after intramuscular injections of bupivacaine was carried out for eva, luating the regeneratory potential of skeletal muscles under conditions of chronic disorders of oxidative metabolism. Lumpy degradation of lesion foci and mononuclear cell infiltration predominated on day 1; after 3 days myoblast proliferation and fusion processes were maximally pronounced; after 7 days maturing myotubules created groups of fibers with central nuclei. At the ultrastructural level, regeneration of the muscle fibers was associated with signs of activation of their nuclei and of satellite cell nuclei. Lesser (in comparison with the control) mean cross-section areas of the muscle fibers on day 14 after the start of the experiment indicated that the regeneration processes were not completed by this term. The proliferative potential of myogenic precursor cells was retained in hereditary dysfunction of mitochondria in OXYS rats.
Nepomnyashchikh
L M
LM
Laboratory of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. pathol@soramn.ru
Bakarev
M A
MA
Tsimmerman
V G
VG
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D002045:Bupivacaine / Q000633:toxicity*; D018482:Muscle, Skeletal / Q000166:cytology / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012038:Regeneration
D000779:Anesthetics, Local; D002045:Bupivacaine