title: [Clinical study of Milan criteria for liver transplantation].
abstract: OBJECTIVE
  To investigate the value and deficiency of Milan criteria for liver transplantation in patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  Between December 2001 and November 2005, 125 patients underwent orthotopic liver transplantation ( OLT), who measured up Milan criteria with preoperation computerized tomography (CT) scanning. The results of pre-transplant multidetector CT scan and post-transplant pathology were retrospectively analyzed, and survival rates were compared.
  
  
  RESULTS
  Pathology examination demonstrated that 97 cases met Milan criteria (77.6%), 26 cases exceeded Milan criteria,and the other 2 cases were diagnosed as nodular cirrhosis. The 1-,2-,3-,4- and 5-year survival rates for those met pre-transplant multidetector CT scanning pre-transplant met Milan criteria vs. those met post-transplant pathology post-transplant criteria were 92.0% vs. 92.8%, 87.2% vs. 90.7%, 86.4% vs. 89.7%, 86.4% vs. 89.7%, and 86.4% vs. 89.7%, respectively. There was no statistic significant difference (P > 0.05). The 1-,2-,3-,4- and 5-year survival rates were 73.0%, 65.4%, 61.5%, 61.5% and 61.5%, for those pathology exceed Milan criteria respectively. The difference between this group and each of the above two were statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  The prognosis of OLT for HCC is good for those met Milan criteria by pre-transplant multidetector CT. Factors leading to poor prognosis such as portal vein tumor thrombi and lymphatic metastasis should be accurately evaluated avoiding for misjudgement.
authors.affiliation: Transplant Center, Tianjin First Central Hospital, Tianjin, China.
authors.forename: Zhong-yang
authors.initials: ZY
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Zheng-lu
authors.initials: ZL
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Shen
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Zhu
authors.forename: Yong-lin
authors.initials: YL
authors.lastname: Deng
authors.forename: Cheng
authors.initials: C
authors.lastname: Pan
authors.forename: Fu-kuan
authors.initials: FK
authors.lastname: Bao
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality / Q000592:standards; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D036542:Tomography, Spiral Computed