title: [QuantiFERON: an early diagnostic tool for cerebral tuberculosis].
abstract: Two cases (a 33-year-old woman and a 34-year-old man) were diagnosed as having cerebral tuberculosis. Case 1 was tuberculoma with miliary tuberculosis complicating cranial nerve palsies, and case 2 was tuberculous meningitis. Early diagnosis was difficult, because smear and PCR were negative. Culture was finally positive after several weeks. QuantiFERON were positive prior to the culture results in both cases. This reaction suggested tuberculous infection. QuantiFERON is useful for diagnosing cerebral tuberculosis at an early stage.
authors.affiliation: Department of Neurology, Tokyo Women's Medical University School of Medicine.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Maruyama
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Iwata
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D008297:Male; D011993:Recombinant Fusion Proteins; D014375:Tuberculoma / Q000175:diagnosis; D020306:Tuberculosis, Central Nervous System / Q000175:diagnosis*; D014390:Tuberculosis, Meningeal / Q000175:diagnosis; D014391:Tuberculosis, Miliary / Q000175:diagnosis
chemical_list: C505464:ESAT-6-CFP10 fusion protein; D011993:Recombinant Fusion Proteins; D007371:Interferon-gamma