Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative.
This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three conferences that will systematically address barriers to translating paradigms developed in the basic animal and human cognitive neuroscience fields for use in translational research aimed at developing novel treatments for cognitive impairments in schizophrenia. The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts.
Carter
Cameron S
CS
Department of Psychiatry, University of California, Davis, CA 95817, USA. cameron.carter@ucdmc.ucdavis.edu
Barch
Deanna M
DM
Buchanan
Robert W
RW
Bullmore
Ed
E
Krystal
John H
JH
Cohen
Jonathan
J
Geyer
Mark
M
Green
Michael
M
Nuechterlein
Keith H
KH
Robbins
Trevor
T
Silverstein
Steven
S
Smith
Edward E
EE
Strauss
Milton
M
Wykes
Til
T
Heinssen
Robert
R
D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D035843:Biomedical Research; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D003299:Cooperative Behavior; D004345:Drug Industry; D006801:Humans; D009315:National Institute of Mental Health (U.S.); D009483:Neuropsychological Tests; D012109:Research Support as Topic; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014481:United States; D014486:United States Food and Drug Administration
D014150:Antipsychotic Agents