title: Unilateral cleft lip/palate children: the incidence of type 6 septal deformities in their parents.
abstract: BACKGROUND
  The overall incidence of pathological septal deformity has been found to be significantly higher in unilateral cleft lip/palate (UCLP) children than in control children. Of the seven types of septal deformity according to Mladina's classification, type 6 has been found to be the most frequent in UCLP children, occurring in only 3.7% of the control children.
  
  
  OBJECTIVE
  To investigate the incidence of type 6 septal deformity in the parents of UCLP children.
  
  
  METHODS
  UCLP children (N=62) and their parents (N=91) were examined for type 6 septal deformities.
  
  
  RESULTS
  Type 6 was found in at least one parent of a UCLP child in 58% of cases. However, it was not found in the parents whose UCLP children did not show a type 6 septal deformity.
  
  
  CONCLUSIONS
  Type 6 septal deformity is almost a rule in children suffering from UCLP. Type 6 was not seen in the parents whose UCLP children did not show a type 6 septal deformity. There is a morphogenetic predisposition for the development of CLP in children whose parents carry a type 6 septal deformity.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University Hospital Salata, Zagreb, Croatia.
authors.forename: Ranko
authors.initials: R
authors.lastname: Mladina
authors.forename: Neven
authors.initials: N
authors.lastname: Skitarelić
authors.forename: Katarina
authors.initials: K
authors.lastname: Vuković
authors.forename: Marin
authors.initials: M
authors.lastname: Subarić
authors.forename: Tomislav
authors.initials: T
authors.lastname: Carić
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Orihovac
mesh_terms: D000293:Adolescent; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D009666:Nose / Q000002:abnormalities*; D010290:Parents; D019655:Quantitative Trait, Heritable