title: Time-dependent 3D simulations of the hemodynamics in a stented coronary artery.
abstract: Stenting is becoming the major interventional cardiology procedure worldwide. However restenosis remains a major limitation to the effectiveness of stents. Alterations to the local hemodynamics in the stented segment of the artery could be a potential factor in the development of in-stent restenosis. The characterization of wall shear stress and of blood flow patterns in a stented artery is therefore necessary for a good understanding of the role of hemodynamics in the development of in-stent restenosis. We have used a time-dependent 3D numerical model of a stented coronary artery to study the characteristics of the blood flow and the shear stress distribution. Our results show that the presence of the stent produces significant secondary flow that is limited to an annulus in the near wall region. Low shear stress zones were localized in the vicinity of the struts while the tips of the struts exhibited high values of shear stress. These results support the hypothesis that local hemodynamics may affect the development of in-stent restenosis and could influence the choice of stent geometries for future stent designs.
authors.affiliation: Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
authors.forename: Isam
authors.initials: I
authors.lastname: Faik
authors.forename: Rosaire
authors.initials: R
authors.lastname: Mongrain
authors.forename: Richard L
authors.initials: RL
authors.lastname: Leask
authors.forename: Josep
authors.initials: J
authors.lastname: Rodes-Cabau
authors.forename: Eric
authors.initials: E
authors.lastname: Larose
authors.forename: Olivier
authors.initials: O
authors.lastname: Bertrand
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000601:surgery; D003331:Coronary Vessels / Q000503:physiopathology* / Q000601:surgery*; D004548:Elasticity; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008955:Models, Cardiovascular; D015607:Stents