title: Chromosomal radiosensitivity in patients with common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency disorders. In addition to recurrent infections and autoimmunity, cancers are more prevalent in these patients than the normal population. Increased radiosensitivity may be a reason for the increased malignancies. To analyze chromosomal radiosensitivity of CVID patients, lymphocytes were cultured from 20 CVID patients. After irradiation (50, 100 cGy), metaphases were evaluated for chromosomal aberrations. Results were compared in patients, healthy individuals, and ataxia telangiectasia as positive controls. Before irradiation there was no difference between groups of patients, but after radiation, the incidence of all kinds of aberrations was higher in the CVID patients and this was statistically significant at 100 cGy (P<0.05). CVID patients appear to be susceptible to in vitro irradiation. These patients should be protected from unnecessary radiographic diagnostic and therapeutic procedures. Also, radiosensitivity may help classifying CVID patients.
authors.affiliation: Department of Allergy and Clinical Immunology of Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Medical Sciences/University of Tehran, Tehran, Iran. aghamohammadi@sina.tums.ac.ir
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
authors.forename: Mostafa
authors.initials: M
authors.lastname: Moin
authors.forename: Ali
authors.initials: A
authors.lastname: Kouhi
authors.forename: Mohammad-Ali
authors.initials: MA
authors.lastname: Mohagheghi
authors.forename: Alireza
authors.initials: A
authors.lastname: Shirazi
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
authors.forename: Sanaz
authors.initials: S
authors.lastname: Tavassoli
authors.forename: Mahbod
authors.initials: M
authors.lastname: Esfahani
authors.forename: Taher
authors.initials: T
authors.lastname: Cheraghi
authors.forename: Jila
authors.initials: J
authors.lastname: Dastan
authors.forename: Jeanet
authors.initials: J
authors.lastname: Nersesian
authors.forename: Saeed Reza
authors.initials: SR
authors.lastname: Ghaffari
mesh_terms: D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000528:radiation effects*; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000150:complications / Q000235:genetics*; D003582:Cytogenetics; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D011836:Radiation Tolerance