title: A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive function.
abstract: OBJECTIVE
  To evaluate the effect of maintenance Interpersonal Psychotherapy (IPT) on recurrence rates and time to recurrence of major depression in elderly patients with varying levels of cognitive function.
  
  
  METHODS
  Two-year maintenance study of monthly maintenance IPT vs supportive clinical management (CM) in remitted depressed elderly who were participants in a previously reported placebo-controlled study of maintenance paroxetine and IPT (Reynolds et al., 2006). We used Cox regression analysis to test interactions between cognitive status (Dementia Rating Scale score) and treatment (IPT, CM) with respect to recurrence of major depression.
  
  
  RESULTS
  We observed a significant interaction between cognitive status and treatment: lower cognitive performance was associated with longer time to recurrence in IPT than in CM (58 weeks vs 17 weeks) (HR = 1.41 [95% CI = 1.04, 1.91], p = 0.03). Subjects with average cognitive performance showed no effect of maintenance IPT vs CM on time to recurrence (38 vs 32 weeks, respectively).
  
  
  CONCLUSIONS
  Monthly maintenance IPT confers protection against recurrence of major depression in elders with lower cognitive functioning.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Carreira
authors.forename: Mark D
authors.initials: MD
authors.lastname: Miller
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.forename: Patricia R
authors.initials: PR
authors.lastname: Houck
authors.forename: Jennifer Q
authors.initials: JQ
authors.lastname: Morse
authors.forename: Mary Amanda
authors.initials: MA
authors.lastname: Dew
authors.forename: Meryl A
authors.initials: MA
authors.lastname: Butters'
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds
mesh_terms: D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003071:Cognition; D003866:Depressive Disorder / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy / Q000379:methods*; D011788:Quality of Life / Q000523:psychology; D055502:Secondary Prevention; D013997:Time Factors
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine