A different TIPE of immune homeostasis.
Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.
Freundt
Eric C
EC
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bidere
Nicolas
N
Lenardo
Michael J
MJ
D000818:Animals; D020169:Caspases / Q000378:metabolism; D016923:Cell Death; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology
D047908:Intracellular Signaling Peptides and Proteins; C529002:TIPE2 protein, mouse; D051193:Toll-Like Receptors; D020169:Caspases