title: Linear growth, growth-hormone secretion and IGF-I generation in children with neglected hypothyroidism before and after thyroxine replacement.
abstract: We studied growth hormone (GH) stimulation and insulin-like growth factor -I (IGF-I) generation tests in 15 children with neglected congenital hypothyroidism (CH) (age = 6.4 +/- 4.2 years) and measured their growth parameters for >1 years after starting thyroxine (T4) replacement. One year after treatment, height SDS (HtSDS) increased from -4.3 +/- 2.5 to -2.7 +/- 2.3. Peak GH response to clonidine increased from 3.2 +/- 1.2 ng ml(-1) to 7.62 +/- 1.38 ng ml(-1) after treatments. Basal and peak IGF-I response to GH increased from (34.66 +/- 17.3 ng ml(-1) and 58.4 +/- 36.99 ng ml(-1), respectively) before treatment to (130.6 +/- 97.8 ng ml(-1) and 193.75 +/- 122.5 ng ml(-1), respectively). HtSDS increments were correlated significantly with basal free T4 concentrations (r = 0.622, P < 0.01). In summary, after long period of hypothyroidism, T4 replacement produced significant, although incomplete, catch-up growth through a partial recovery of GH- IGF-I axis.
authors.affiliation: Department of Pediatrics, University of Alexandria Children's Hospital, El Chatby, Alexandria, Egypt. ATSOLIMAN@yahoo.com
authors.forename: Ashraf T
authors.initials: AT
authors.lastname: Soliman
authors.forename: Magdy
authors.initials: M
authors.lastname: Omar
authors.forename: Ahmad
authors.initials: A
authors.lastname: El Awwa
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Rizk
authors.forename: Rania K
authors.initials: RK
authors.lastname: El Alaily
authors.forename: Elsaid M A
authors.initials: EM
authors.lastname: Bedair
mesh_terms: D001827:Body Height / Q000187:drug effects*; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000097:blood* / Q000188:drug therapy*; D004534:Egypt; D006128:Growth / Q000187:drug effects; D019382:Human Growth Hormone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D012189:Retrospective Studies; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013974:Thyroxine