Recognizing doxycycline-induced esophageal ulcers in dental practice: a case report and review.
BACKGROUND
Doxycycline-induced esophageal ulcer is a documented adverse drug reaction. Unfortunately, many health care professionals are not familiar with this particular drug reaction. Because doxycycline frequently is prescribed in the clinical practice of periodontics, it is important for dentists to be aware of this potential drug reaction.


METHODS
The authors describe the case of a patient who was taking doxycycline after undergoing periodontal surgery and experienced a complication. The diagnosis revealed that the patient had developed an esophageal ulcer as a result of taking the doxycycline.


RESULTS
The patient's esophageal ulcer resolved with the aid of dietary changes and a prescription of rabeprazole, a proton pump inhibitor.


CONCLUSIONS
and


CONCLUSIONS
The etiology of doxycycline-induced esophageal ulceration is complex, and proper diagnosis is essential for its resolution. Dentists should be aware of the potential for this adverse drug reaction.
Segelnick
Stuart L
SL
Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York City, NY, USA. EperioDr@aol.com
Weinberg
Mea A
MA
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003094:Collagen; D004035:Diet Therapy; D004318:Doxycycline / Q000009:adverse effects*; D004935:Esophageal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005889:Gingival Recession / Q000601:surgery*; D006801:Humans; D010353:Patient Education as Topic; D011182:Postoperative Care; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D064750:Rabeprazole; D017768:Skin, Artificial; D014456:Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; C440568:Alloderm; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D003094:Collagen; D004318:Doxycycline