Effect of dalargin on DNA synthesis in the gastric mucosa of albino rats.
3H-thymidine autoradiography and chemiluminescence study demonstrated pronounced effect of dalargin on the state of the gastric mucosa in albino rats. Dalargin stimulated DNA synthesis in the epithelium of the gastric mucosa and increased buffer capacity of its antiradical and antioxidant systems. Dalargin analogue not containing arginine ([D-Ala2]-leu-enkephalin) had little effect on these parameters. NO synthase inhibitor L-NAME abolished the effects of dalargin on DNA synthesis in the gastric mucosa. Our results suggest that the NO system plays an important role in the effect of dalargin on the gastric mucosa.
Zivotova
E U
EU
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk.
Fleishman
M U
MU
Lebedko
O A
OA
Sazonova
E N
EN
Timoshin
S S
SS
D000818:Animals; D049109:Cell Proliferation; D004247:DNA / Q000096:biosynthesis*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004745:Enkephalins / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000378:metabolism; D005753:Gastric Mucosa / Q000502:physiology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats
D004745:Enkephalins; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D019331:NG-Nitroarginine Methyl Ester