Preventing aneuploidy: the contribution of mitotic checkpoint proteins.
Aneuploidy, an abnormal number of chromosomes, is a trait shared by most solid tumors. Chromosomal instability (CIN) manifested as aneuploidy might promote tumorigenesis and cause increased resistance to anti-cancer therapies. The mitotic checkpoint or spindle assembly checkpoint is a major signaling pathway involved in the prevention of CIN. We review current knowledge on the contribution of misregulation of mitotic checkpoint proteins to tumor formation and will address to what extent this contribution is due to chromosome segregation errors directly. We propose that both checkpoint and non-checkpoint functions of these proteins contribute to the wide array of oncogenic phenotypes seen upon their misregulation.
Suijkerbuijk
Saskia J E
SJ
Department of Physiological Chemistry, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Kops
Geert J P L
GJ
D000782:Aneuploidy; D000818:Animals; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000502:physiology; D002470:Cell Survival; D043171:Chromosomal Instability; D020090:Chromosome Segregation / Q000502:physiology; D006801:Humans; D064246:Mad2 Proteins; D051379:Mice; D008938:Mitosis / Q000502:physiology*; D023421:Models, Animal; D009369:Neoplasms / Q000209:etiology*; D009687:Nuclear Proteins / Q000502:physiology; D049468:Prometaphase / Q000502:physiology; D017346:Protein Serine-Threonine Kinases; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
C577495:CDC20 protein, S cerevisiae; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; C501382:MAD1 protein, S cerevisiae; C577695:MAD2 protein, S cerevisiae; D064246:Mad2 Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases