title: Anophthalmia, cleft lip/palate, absent vomer bone, nystagmus, and mental-motor retardation: a new syndrome or Fryns "anophthalmia-plus" syndrome?
abstract: OBJECTIVE
  We report that a 4-year-old boy presented with right unilateral complete cleft lip and palate, right anophthalmos, left congenital nystagmus, absence of the vomer bone, mental-motor retardation, and normal lymphocyte karyotype (46, XY).
  
  
  METHODS
  For reconstruction of the deformities, we performed cleft lip repair by Millard's rotation-advancement technique and planned cleft palate repair.
  
  
  CONCLUSIONS
  This combination of cleft lip and palate, anophthalmos, congenital nystagmus, absent vomer bone, and mental-motor retardation has not, to our knowledge, previously been described. We suggest that this represents either another case of the rare Fryns "anophthalmia-plus" syndrome or a new syndrome.
authors.affiliation: Department of Plastic, Reconstructive, and Aesthetic Surgery, Düzce University, Düzce Medical Faculty, Düzce, Turkey. deryaozcelik68@yahoo.com
authors.forename: Derya
authors.initials: D
authors.lastname: Ozçelik
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sağlam
authors.forename: Fatma
authors.initials: F
authors.lastname: SIlan
authors.forename: Gülbin
authors.initials: G
authors.lastname: Sezen
authors.forename: Toygar
authors.initials: T
authors.lastname: Unveren
mesh_terms: D000015:Abnormalities, Multiple; D000853:Anophthalmos; D002675:Child, Preschool; D002971:Cleft Lip / Q000601:surgery*; D002972:Cleft Palate; D006801:Humans; D008607:Intellectual Disability; D008297:Male; D009300:Nasal Septum / Q000002:abnormalities; D020417:Nystagmus, Congenital; D013577:Syndrome