title: Symptom concerns and quality of life in hepatobiliary cancers.
abstract: OBJECTIVE
  To describe the symptom concerns of patients with hepatocellular carcinoma (HCC) and pancreatic cancer and explore the effect of symptoms on patients' quality of life (QOL).
  
  
  METHODS
  Descriptive, longitudinal study.
  
  
  METHODS
  Ambulatory clinics of a comprehensive cancer center.
  
  
  METHODS
  45 patients actively receiving treatment for either HCC or pancreatic cancer.
  
  
  METHODS
  Patients were followed from baseline for three months, with outcome measures repeated monthly. Outcome measures included the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) and the Functional Assessment of Chronic Illness Therapy-Spirituality Subscale (FACIT-Sp-12). Descriptive analysis of demographic, treatment, and symptom data was conducted, followed by two-way repeated measures analysis of variance of FACT-Hep and FACIT-Sp-12 scale scores by diagnosis and treatment type.
  
  
  METHODS
  Symptoms, QOL.
  
  
  RESULTS
  Overall QOL is poor in patients with hepatobiliary cancer, and this trend continues over time. Symptoms such as abdominal pain, fatigue, weight loss, and poor appetite commonly are reported in this population.
  
  
  CONCLUSIONS
  Patients with hepatobiliary cancer suffer from multiple symptoms that may have a negative affect on overall QOL. Specific QOL domains, such as physical and functional well-being, are of particular concern for patients.
  
  
  CONCLUSIONS
  The identification of specific symptom and QOL concerns in hepatobiliary cancers will enhance clinical care and aid in the future development of multidisciplinary interventions for this understudied cancer population.
authors.affiliation: Department of Nursing Research and Education, City of Hope, Duarte, CA, USA. vsun@coh.org
authors.forename: Virginia
authors.initials: V
authors.lastname: Sun
authors.forename: Betty
authors.initials: B
authors.lastname: Ferrell
authors.forename: Gloria
authors.initials: G
authors.lastname: Juarez
authors.forename: Lawrence D
authors.initials: LD
authors.lastname: Wagman
authors.forename: Yun
authors.initials: Y
authors.lastname: Yen
authors.forename: Vincent
authors.initials: V
authors.lastname: Chung
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000203:Activities of Daily Living / Q000523:psychology; D000223:Adaptation, Psychological; D000704:Analysis of Variance; D000855:Anorexia / Q000209:etiology; D001294:Attitude to Health; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000523:psychology* / Q000628:therapy; D005221:Fatigue / Q000209:etiology; D005260:Female; D006301:Health Services Needs and Demand; D006304:Health Status; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000523:psychology* / Q000628:therapy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D024802:Nurse's Role; D015404:Nursing Methodology Research; D009859:Oncology Nursing; D017063:Outcome Assessment, Health Care; D010190:Pancreatic Neoplasms / Q000150:complications / Q000523:psychology* / Q000628:therapy; D011788:Quality of Life / Q000523:psychology*; D029181:Spirituality; D011795:Surveys and Questionnaires; D015431:Weight Loss