title: The effects of nitric oxide donors on the sporulation of Eimeria tenella oocysts.
abstract: Nitric oxide (NO) is involved in many physiological processes including regulation of blood pressure, immune response, and neural communication. The effects of NO donors on the sporogony of Eimeria tenella oocysts and the blocking effects of NO scavenger, hemoglobin (Hb), against NO donors were investigated in this study. The results showed that the sporulation of oocysts could be completely inhibited by acidic sodium nitrite (NaNO2), S-nitroso-glutathione (GSNO) or S-nitroso-N-acetyl-dl-penicillamine (SNAP) in profound dose-dependent and time-dependent manners, and the inhibiting process was irreversible and not affected by feces of chickens. However, not all NO donors in this study, such as sodium nitroprusside (SNP), demonstrated above-mentioned effect. The NO scavenger Hb could significantly prevent the detrimental effects of NO donors on the sporogony of oocysts in a dose-dependent manner. At present, the inhibiting mechanism of NO donors on the sporulation of oocysts was still unclear.
authors.affiliation: The Key Lab of Jiangsu Provence for Animal Preventive Medicine, School of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China. jingui_li@163.com <jingui_li@163.com>
authors.forename: J G
authors.initials: JG
authors.lastname: Li
authors.forename: Z P
authors.initials: ZP
authors.lastname: Liu
authors.forename: J P
authors.initials: JP
authors.lastname: Tao
mesh_terms: D000818:Animals; D002645:Chickens / Q000469:parasitology; D016786:Eimeria tenella / Q000187:drug effects* / Q000502:physiology*; D005973:Glutamine / Q000494:pharmacology; D006454:Hemoglobins; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D033661:Oocysts / Q000187:drug effects* / Q000502:physiology; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D026422:S-Nitrosoglutathione / Q000494:pharmacology; D012977:Sodium Nitrite / Q000737:chemistry / Q000494:pharmacology; D033761:Spores, Protozoan / Q000187:drug effects* / Q000502:physiology
chemical_list: D006454:Hemoglobins; D020030:Nitric Oxide Donors; C110881:S-nitro-N-acetylpenicillamine; D005973:Glutamine; D026422:S-Nitrosoglutathione; D010396:Penicillamine; D012977:Sodium Nitrite