title: Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis.
abstract: Human carcinomas arise through the acquisition of genetic changes that endow precursor cancer cells with a critical threshold of cancer-relevant genetic lesions. This complex genomic alterations confer upon precursor cancer cells the ability to grow indefinitely and to metastasize to distant sites. One important mechanism underlying a cell's tumorigenic potential is the status of its telomere. Telomeres are G-rich simple repeat sequences that serve to prevent chromosomal ends from being recognized as DNA double-strand breaks (DSBs). Dysfunctional telomeres resemble DSBs, leading to the formation of dicentric chromosomes that fuel high degrees of genomic instability. In the setting of an intact p53 pathway, this instability promotes cellular senescence, a potent tumor suppressor mechanism. However, rare cells that stochastically lose p53 function emerge from this sea of genomic instability and progress towards cancer. In this review, we describe the use of mouse models to probe the impact of dysfunctional telomeres on tumor initiation and suppression.
authors.affiliation: Department of Cancer Genetics, Box 1006, The M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: Wilfredo
authors.initials: W
authors.lastname: Cosme-Blanco
authors.forename: Sandy
authors.initials: S
authors.lastname: Chang
mesh_terms: D000818:Animals; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D019098:Telomerase