Comparative study of cardioprotective effects of uridine-5'-monophosphate and uridine-5'-triphosphate during the early periods of acute myocardial ischemia.
In experiments on rats, uridine-5'-monophosphate and uridine-5'-triphosphate reduced the intensity of anaerobic glycolysis and preserved glycogen stores and creatine phosphate balance during the first 60 min after occlusion of the left coronary artery. However, the energy-protective effect of uridine-5'-triphosphate developed 15 min later than the effect of uridine-5'-monophosphate. Uridine-5'-monophosphate, but not uridine-5'-triphosphate, reduced T wave amplitude on ECG and decreased the volume of ischemic injury to the myocardium.
Bul'on
V V
VV
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. sns@iem.spb.ru
Krylova
I B
IB
Rodionova
O M
OM
Selina
E N
EN
Evdokimova
N R
NR
Sapronov
N S
NS
D000818:Animals; D002316:Cardiotonic Agents / Q000378:metabolism*; D004734:Energy Metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014542:Uridine Monophosphate / Q000378:metabolism*; D014544:Uridine Triphosphate / Q000378:metabolism*
D002316:Cardiotonic Agents; D014542:Uridine Monophosphate; D014544:Uridine Triphosphate