title: nuScore: a web-interface for nucleosome positioning predictions.
abstract: Sequence-directed mapping of nucleosome positions is of major biological interest. Here, we present a web-interface for estimation of the affinity of the histone core to DNA and prediction of nucleosome arrangement on a given sequence. Our approach is based on assessment of the energy cost of imposing the deformations required to wrap DNA around the histone surface. The interface allows the user to specify a number of options such as selecting from several structural templates for threading calculations and adding random sequences to the analysis.
  
  
  BACKGROUND
  The nuScore interface is freely available for use at http://compbio.med.harvard.edu/nuScore.
  
  
  BACKGROUND
  peter_park@harvard.edu; tolstorukov@gmail.com
  
  
  BACKGROUND
  The site contains user manual, description of the methodology and examples.
authors.affiliation: Harvard-Partners Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, MA 02115, USA. tolstorukov@gmail.com
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tolstorukov
authors.forename: Vidhu
authors.initials: V
authors.lastname: Choudhary
authors.forename: Wilma K
authors.initials: WK
authors.lastname: Olson
authors.forename: Victor B
authors.initials: VB
authors.lastname: Zhurkin
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Park
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D020407:Internet; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D009707:Nucleosomes