[Infectious mononucleosis in patients with inflammatory bowel disease under treatment with azathioprine].
The use of immunomodulators for the treatment of inflammatory bowel disease is increasing. One of the most common adverse effects associated with this kind of drugs are infectious complications. In recent years, special attention has been paid to certain latent infections which, in patients under immunomodulatory therapy, can be reactivated and prove lethal. Consequently, preventive actions have been adopted, such as screening for hepatitis B virus and tuberculosis infection before starting these treatments. Primary infection with the Epstein-Barr herpesvirus is usually asymptomatic. However, this virus can have an aggressive course and even lead to the development of lymphoma. We report two cases of atypical infectious mononucleosis in patients with inflammatory bowel disease under azathioprine therapy and review the available evidence on the most appropriate therapeutic approach in this subset of patients.
Bargalló
Ana
A
Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.
Carrión
Silvia
S
Domènech
Eugeni
E
Arévalo
Juan Antonio
JA
Mañosa
Míriam
M
Cabré
Eduard
E
Cabriada
José Luis
JL
Gassull
Miquel Angel
MA
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007244:Infectious Mononucleosis / Q000209:etiology*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008297:Male
D007166:Immunosuppressive Agents; D001379:Azathioprine