Type 3 deiodinase in hypoxia: to cool or to kill?
Type 3 deiodinase (D3) inactivates thyroid hormones. Simonides et al. (2008) now report that hypoxia-induced D3 activation leads to reduction of 3,5,3'-triiodothyronine (T3) and oxygen consumption, suggesting that D3 activation is a component of cellular responses to hypoxia and supporting the idea of cell-specific regulation of thyroid hormone levels by deiodinases.
Diano
Sabrina
S
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA. sabrina.diano@yale.edu
Horvath
Tamas L
TL
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D000860:Hypoxia / Q000201:enzymology*; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D007453:Iodide Peroxidase / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
D051793:Hypoxia-Inducible Factor 1; C117274:iodothyronine deiodinase type III; D007453:Iodide Peroxidase