Stereoselective one-pot synthesis of oxazolines.
Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields. The reaction is equally applicable to chalcones.
Hajra
Saumen
S
Department of Chemistry, Indian Institute of Technology, Kharagpur, India. shajra@chem.iitkgp.ernet.in
Bar
Sukanta
S
Sinha
Debarshi
D
Maji
Biswajit
B
D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D010080:Oxazoles / Q000138:chemical synthesis*; D013237:Stereoisomerism
D010080:Oxazoles