Antiaggregant effects of biogenic chloramines.
Alanine and taurine sharply potentiate antiaggregant effects of hypochlorite on platelets in platelet-rich plasma. This effect is determined by more pronounced action of chloramine derivatives, products of interaction of added amino acids with hypochlorite. Platelets are more sensitive to the inhibitory effects of amino acid chloramine derivatives (biogenic chloramines) compared to erythrocytes and neutrophils. The antiaggregant effects of biobenic amines, as covalent platelet inhibitors, in platelet-rich plasma are characterized by their increased reaction capacity with molecular targets in cells. Quantitative parameter of this initial selectivity (ratio of rate constant of inactivation of platelet receptors to rate constant of side reaction with plasma proteins) far surpasses 1. N,N-Dichlorotaurine is a perspective antiaggreant among the studied biogenic chloramines. This agent is stable and exhibits specific pharmacological activity in all test systems, including animal model of thrombosis.
Murina
M A
MA
Research Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow. marina_murina@mail.ru
Roshchupkin
D I
DI
Kravchenko
N N
NN
Petrova
A O
AO
Sergienko
V I
VI
D000409:Alanine / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002700:Chloramines / Q000737:chemistry / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D010974:Platelet Aggregation / Q000502:physiology*; D011817:Rabbits; D013654:Taurine / Q000737:chemistry / Q000378:metabolism*
D002700:Chloramines; D013654:Taurine; C030816:chloramine; D000409:Alanine