[Action mechanism of growth factors].
It is known that growth factors act with cells according to endocrine, paracrine, autocrine, intracrine, juxtacrine, and matricrine mechanisms. Four mechanisms of the formers are diffusible and two of the latters non-diffusible. It is considered that the signal transduction of diffusible growth factors is significantly different from that of non-diffusible ones. It is important to design growth factors for tissue engineering, regenerative medicine, and cell culture system by taking the mechanisms into consideration.
Ito
Yoshihiro
Y
Nano Medical Engineering Laboratory, RIKEN.
D000818:Animals; D002450:Cell Communication / Q000235:genetics / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D011994:Recombinant Proteins; D044968:Regenerative Medicine; D023822:Tissue Engineering
D036341:Intercellular Signaling Peptides and Proteins; D011994:Recombinant Proteins