Application of MEMS technology and engineering in medicine: a new paradigm for facial muscle reanimation.
Translational research may lead to development of micro-electromechanical system-based devices to treat muscle and nerve dysfunctions whose current treatments are inadequate and, at best, palliative. This paper discusses the development of engineered microsystems as a treatment option for palsies of the seventh cranial nerve and the potential application of these devices as a platform technology for treatment of other nervous dysfunctions. The engineering techniques for electrical and chemical stimulation of denervated muscle are discussed along with current caveats from clinical and engineering standpoints. As opposed to current treatments, miniaturized implants offer the possibility of the reduced toxicity and increased specificity of direct drug delivery. As with the increased miniaturization of other technologies, engineering of these increasingly small implantable microsystems holds great promise for the future development of yet smaller, even nanoscale, implantable devices.
Cockerham
Kimberly
K
Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA. kpcorb@aol.com
Aro
Seppo
S
Liu
Wentai
W
Pantchenko
Oxana
O
Olmos
Andrea
A
Oehlberg
Mark
M
Sivaprakasam
Mohanasankar
M
Crow
Lauren
L
D016503:Drug Delivery Systems; D004558:Electric Stimulation; D005152:Facial Muscles / Q000473:pathology*; D006801:Humans; D013677:Medical Laboratory Science / Q000379:methods*; D036103:Nanotechnology; D009422:Nervous System Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*