Oncogene and tumor suppressor gene expression changes in the peripheral blood leukocytes of patients with colorectal cancer.
OBJECTIVE
The mortality of colorectal cancer continues to stagnate despite the development of new therapeutic approaches. Therefore, identifying high-risk population groups could contribute to the prevention of a considerable part of deaths caused by colorectal tumors.


METHODS
Fifty patients with colon cancer and 50 patients with other, nonmalignant diseases were selected for the study. Expression of the c-myc, Ha-ras and p53 genes was determined in the peripheral leukocytes of the participants.


RESULTS
Marked elevations of the expression of all three investigated genes were seen in the colon cancer patients when compared to the controls.


CONCLUSIONS
Our investigations showed that increases in the expression of c-myc, Ha-ras and p53 genes can be demonstrated in the peripheral leukocytes of colon cancer patients. By applying our method to clinical investigations, individuals with a high risk of having developed colon cancer may be identified and early diagnosis may be established.
Csontos
Zsolt
Z
Department of Surgery Faculty of Medicine, Faculty of Medicine, Pécs University of Sciences, Pécs, Hungary.
Nádasi
Edit
E
Csejtey
András
A
Illényi
László
L
Kassai
Miklós
M
Lukács
László
L
Kelemen
Dezso
D
Kvarda
Attila
A
Zólyomi
Annamária
A
Horváth
Ors Péter
OP
Ember
István
I
D000230:Adenocarcinoma / Q000097:blood*; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
D014408:Biomarkers, Tumor; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53