Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex.
We studied the effect of prostaglandins on presynaptic NMDA receptors. Prostaglandin E2 inhibited NMDA-induced (45)Ca2+ uptake by synaptosomes in low concentrations (IC50 approximately 10 microM), but potentiated it in higher concentrations. Prostaglandin D2 increased (45)Ca2+ uptake by synaptosomes during stimulation of NMDA receptors. Our results indicate that prostaglandins D2 and E2 modulate function of presynaptic NMDA receptors.
Petrova
L N
LN
Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chemogolovka. plv@icp.ac.ru
Gabrelian
A V
AV
Serkov
I V
IV
Bachurin
S O
SO
D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate; D015232:Dinoprostone; D015230:Prostaglandin D2; D002118:Calcium