title: Evidence-based management of one-lung ventilation.
abstract: One-lung ventilation (OLV) is essential for many thoracic and an increasing number of non-thoracic minimally invasive procedures. Beyond the well-recognized disturbance of ventilation-perfusion matching, recent years have seen a mounting body of evidence implicating OLV in the creation of acute lung injury. After reviewing the fundamentals of OLV physiology, this article examines the evidence for altering individual ventilatory parameters toward protective OLV.
authors.affiliation: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver Acute, Vancouver General Hospital, Vancouver, British Columbia V5Z 1M9, Canada. jens.lohser@vch.ca
authors.forename: Jens
authors.initials: J
authors.lastname: Lohser
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D019317:Evidence-Based Medicine; D006801:Humans; D006935:Hypercapnia / Q000628:therapy; D000860:Hypoxia / Q000628:therapy; D007431:Intraoperative Complications / Q000628:therapy; D008168:Lung / Q000502:physiology; D010100:Oxygen / Q000494:pharmacology; D011175:Positive-Pressure Respiration; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology; D012121:Respiration, Artificial; D019616:Thoracic Surgical Procedures; D013990:Tidal Volume / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000777:Anesthetics; D010100:Oxygen