title: Simple and efficient microwave assisted N-alkylation of isatin.
abstract: We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried out under different conditions, always employing methodologies compatible with MW assisted chemistry. Generation of isatin anion employing diverse bases and solvents or using the preformed isatin sodium salt was tested. The best results were achieved using K(2)CO(3) or Cs(2)CO(3) and a few drops of N,N-dimethylformamide or N-methyl-2-pyrrolidinone. These reactions present noteworthy advantages over those carried out employing conventional heating.
authors.affiliation: Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113) Buenos Aires, República Argentina.
authors.forename: María Sol
authors.initials: MS
authors.lastname: Shmidt
authors.forename: Ana María
authors.initials: AM
authors.lastname: Reverdito
authors.forename: Lautaro
authors.initials: L
authors.lastname: Kremenchuzky
authors.forename: Isabel Amalia
authors.initials: IA
authors.lastname: Perillo
authors.forename: María Mercedes
authors.initials: MM
authors.lastname: Blanco
mesh_terms: D000478:Alkylation; D004852:Epoxy Compounds / Q000138:chemical synthesis; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves
chemical_list: D004852:Epoxy Compounds; D007510:Isatin