Synthesis of Bis-18,18'-desmethyl Ritterazine N.
Bis-18,18'-desmethyl ritterazine N has been prepared in enantiomerically pure form. The synthetic alkaloid, lacking only two of the 52 carbon atoms of the natural product, shows selective activity in the NIH 60 cell panel.
Taber
Douglass F
DF
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA. taberdf@udel.edu
Joerger
Jean-Michel
JM
D000478:Alkylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
D011719:Pyrazines; D013141:Spiro Compounds; D013256:Steroids; C516092:ritterazine N