title: Prophylaxis: headaches that never happen.
abstract: The discovery of preventive drugs for headache involved both serendipity and design. Despite modest efficacy and uncertainty about mechanisms, prophylaxis has transformed the lives of countless headache sufferers in the last 50 years. Realizing its full potential will be the work of the next half-century.
authors.affiliation: Division of Headache and Pain, Department of Neurology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Loder
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006261:Headache / Q000188:drug therapy / Q000266:history* / Q000517:prevention & control*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000929:Antidepressive Agents, Tricyclic; D002121:Calcium Channel Blockers; D012702:Serotonin Antagonists; D008094:Lithium