title: Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production.
abstract: We evaluated the efficacy of loxoprofen sodium for refractory nocturia. Twelve men (mean age, 75.1 +/- 5.7) with nocturia were enrolled in this study. All patients received 60 mg loxoprofen sodium prior to sleeping at night for 14 days. Nine of 12 patients (75%) felt more satisfaction than previous treatments. Patients were grouped into a loxoprofen sodium-effective (n = 7) and ineffective groups (n = 5) based on the results of the frequency-volume chart. In the effective group, interestingly, night-time urine volume showed significant reduction (P < 0.05). On the other hand, the average single voided volume at night and 24-h urine volume showed no significant change. There was a statistically significant difference in the night-time urine volume after treatment between groups (P < 0.01). Loxoprofen sodium is an effective treatment for some patients with refractory nocturia. The main effect mechanism of loxoprofen sodium may involve the reduction of night-time urine production.
authors.affiliation: Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, and Department of Urology, Jousai Municipal Hospital, Nagoya, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Okada
authors.forename: Hideki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kojima
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Yanai
authors.forename: Shoichi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kohri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D053158:Nocturia / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D014556:Urine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; C040656:loxoprofen