Association between arterial stiffness and peritoneal small solute transport rate.
While cardiovascular disease accounts for 40-50% of the mortality in dialysis patients, and while a high peritoneal transport in continuous ambulatory peritoneal dialysis (CAPD) is an independent predictor of outcome, it is unclear if there are any links. Aortic stiffness has become established as a cardiovascular risk factor. We thus studied pulse wave velocity (PWV) in CAPD patients to explore the possible link between peritoneal small solute transport and aortic stiffness. CAPD patients (n = 76, 27 M/49 F) in our center were included in the present study. Aortic stiffness was assessed by brachial pulse pressure (PP) and carotid-femoral PWV. Patients' peritoneal small solute transport rate was assessed by D/P(cr) at 4 h. Extracellular water over total body water (E/T ratio) was assessed by means of bioimpedance analysis. C-reactive protein was also measured. Carotid-femoral PWV was positively associated with patients' age (r = 0.555; P < 0.01), time on peritoneal dialysis (r = 0.332; P < 0.01), diabetic status (r = 0.319; P < 0.01), D/P(cr) (r = 0.241; P < 0.05), PP (r = 0.475; P < 0.01), and E/T (r = 0.606; P < 0.01). In a multivariate regression analysis, carotid-femoral PWV was independently determined by E/T (P < 0.01), PP (P < 0.01), age (P < 0.01), and D/P(cr) (P < 0.05). D/P(cr), in addition to E/T, age, and PP, was an independent predictor of elevated carotid-femoral PWV in CAPD patients, suggesting that there might be a link between high aortic stiffness and increased peritoneal small solute transport rate.
Zhe
Xing-wei
XW
Division of Nephrology, Peking University Third Hospital, Beijing, China.
Tian
Xin-kui
XK
Chen
Wei
W
Guo
Li-juan
LJ
Gu
Yue
Y
Chen
Hui-min
HM
Tang
Li-jun
LJ
Wang
Tao
T
D000367:Age Factors; D000368:Aged; D001161:Arteriosclerosis / Q000503:physiopathology*; D001794:Blood Pressure; D001823:Body Composition; D001834:Body Water / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions; D017097:Electric Impedance; D045604:Extracellular Fluid / Q000502:physiology; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012044:Regression Analysis
D015314:Dialysis Solutions; D002097:C-Reactive Protein; D003404:Creatinine