title: Effect of an orally ingested mugwort and mushroom extract mixture on urine odor from aged mice.
abstract: We had previously found that male mice could be trained to discriminate between the urine odor of aged and young adult (adult) mice. We hypothesized that these odors that characterized the older animals might be inhibited by a mixture of extracts (AAM) of mugwort and mushroom, because previous studies have indicated that these extracts could be used to reduce the intensity of unpleasant body odors. The findings of this chemical study strongly suggest that the AAM function helped to modify the aged mouse urine odor so that it more closely resembled the smell of urine from younger mice. Based on the results of the chemical studies, a set of behavioral experiments were therefore conducted. The results of three sets of generalization trials also strongly supported the results of the chemical studies. Together, these results suggest that ingested AAM decreased the intensity of odors associated with aging in mice.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA. mail: osadak@hoku-iryo-u.ac.jp
authors.forename: Kazumi
authors.initials: K
authors.lastname: Osada
authors.forename: Maryanne
authors.initials: M
authors.lastname: Curran
authors.forename: Michio
authors.initials: M
authors.lastname: Kurachi
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsunoda
authors.forename: Kunio
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000284:Administration, Oral; D000363:Agaricales / Q000737:chemistry*; D000375:Aging; D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D001525:Behavioral Sciences; D045424:Complex Mixtures / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005410:Flame Ionization; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D009812:Odorants; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D014556:Urine / Q000737:chemistry*
chemical_list: D045424:Complex Mixtures; D010936:Plant Extracts