Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells.
Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of (60)Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After gamma irradiation, interleukin (IL)-1alpha, IL-1beta and tumor necrosis factor (TNF)-alpha remained undetectable in both cell supernatants and cell lysates. However, a dose-dependent increase in the production of IL-6 and IL-8 has been demonstrated up to 6 days after exposure. These data indicate that the pro-inflammatory cytokines IL-6 and IL-8 may be involved in the inflammatory response of vascular endothelium induced by exposure to ionizing radiation.
Meeren
A V
AV
Institut de Protection et de Sûreté Nucléaire Département de Protection de la santé de l'Homme et de Dosimétrie Section Autonome de Radiobiologie Appliquée à la Médecine IPSN, BP n ˚6, Fontenay-aux-Roses Cédex F-92265 France.
Bertho
J M
JM
Vandamme
M
M
Gaugler
M H
MH