title: Whole tumour perfusion of peripheral lung carcinoma: evaluation with first-pass CT perfusion imaging at 64-detector row CT.
abstract: OBJECTIVE
  To prospectively assess the feasibility of a whole-tumour perfusion technique using 64-detector row computed tomography (CT) and to analyse the variation of CT perfusion parameters in different histological types, sizes, and metastases in patients with peripheral lung carcinoma.
  
  
  METHODS
  Ninety-seven pathologically proved peripheral lung carcinomas (less than 5 cm in largest diameter) underwent dynamic contrast-enhanced CT using a 64-detector row CT machine. Small amounts of iodinated contrast medium with a sharp bolus profile (50 ml, 6-7 ml/s), and 12 repeated fast acquisitions encompassing the entire tumour lesion were adopted to quantify perfusion of the whole-tumour during first-pass of contrast medium. Four kinetic parameters, including perfusion, peak enhancement intensity (PEI), time to peak (TTP), and blood volume (BV), were measured and statistically compared among different histological types, sizes, and metastases.
  
  
  RESULTS
  Mean values for perfusion, PEI, TTP, and BV of the 97 lung carcinomas were 57.5+/-45.4 ml/min/ml (range 5.9-243 ml/min/ml), 53.4+/-40.6 HU (range 10.3-234.4 HU), 34+/-11s (range 11-60s), and 30.1+/-21.7 ml/100g (range 3.9-113.4 ml/100g), respectively. No statistical differences were found between the histological types regarding the perfusion parameters (p>0.05). Perfusion, PEI, and BV of stage T2 tumours were significantly lower than those of stage T1 tumours (all p < 0.05), whereas no statistically significant differences was found between other stages of tumours (all p>0.05). Perfusion of the tumours with distant metastasis was significantly higher than that of the tumours without distant metastasis (p<0.05), but there was no statistically significant difference between nodal metastasis positive and negative groups (p>0.05).
  
  
  CONCLUSIONS
  The present study of first-pass perfusion imaging using 64-detector row CT could provide a feasible method for assessment of whole-tumour perfusion. CT perfusion parameters of peripheral lung carcinoma may be associated with tumour size and distant metastasis.
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Yang
authors.forename: T-W
authors.initials: TW
authors.lastname: Chen
authors.forename: Y-P
authors.initials: YP
authors.lastname: Deng
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Yu
authors.forename: Z-L
authors.initials: ZL
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods; D011446:Prospective Studies; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media