Flexible porous metal-organic frameworks for a controlled drug delivery.
Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
Horcajada
Patricia
P
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
Serre
Christian
C
Maurin
Guillaume
G
Ramsahye
Naseem A
NA
Balas
Francisco
F
Vallet-Regí
María
M
Sebban
Muriel
M
Taulelle
Francis
F
Férey
Gérard
G
D000327:Adsorption; D017608:Chromium Compounds / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D008958:Models, Molecular; D010795:Phthalic Acids / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D017608:Chromium Compounds; D003692:Delayed-Action Preparations; D005290:Ferric Compounds; D010795:Phthalic Acids; C011363:terephthalic acid; D007052:Ibuprofen