Exercise-induced stem cell activation and its implication for cardiovascular and skeletal muscle regeneration.
A number of publications have provided evidence that exercise and physical activity are linked to the activation, mobilization, and differentiation of various types of stem cells. Exercise may improve organ regeneration and function. This review summarizes mechanisms by which exercise contributes to stem cell-induced regeneration in the cardiovascular and the skeletal muscle system. In addition, it discusses whether exercise may improve and support stem cell transplantation in situations of cardiovascular disease or muscular dystrophy.
Wahl
Patrick
P
Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University, Cologne, Germany.
Brixius
Klara
K
Bloch
Wilhelm
W
D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy; D002319:Cardiovascular System / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D009136:Muscular Dystrophies / Q000628:therapy; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism*