title: [Cholestasis in infants: a study of the Children's Hospital of Tunisia].
abstract: BACKGROUND
  Cholestasis in infant constitutes an heterogeneous group of disease; diagnosis and management are often difficult. THE AIM of the study is to describe clinical, paraclinical characteristics and outcome of infants hospitalized for cholestasis in children's Hospital of Tunis.
  
  
  METHODS
  A retrospective study of 94 infants with cholestasis was conducted. Patients were hospitalized in four departments of paediatrics of our hospital between January 1995 and December 2005. Cholestasis complicating severe sepsis and visceral leishmaniasis were excluded.
  
  
  RESULTS
  Incidence of cholestasis was 8.5 cases/year which represented 0.72% of the hospitalizations. Sex ratio was 1.08 and mean age at diagnosis was 105 days (extremes: 1 day- 24 months). Biliary atresia was the most common cause of extra hepatic cholestasis (13.8%). Normal A GT cholestasis (11.7 %), benign neonatal cholestasis (11.7%) and bile duct hypoplasia (9.5%) represented the most common aetiologies of intra hepatic cholestasis. Aetiology remained unknown in 12.7% of cases. Only three infants with biliary atresia had Kasaï operation. After a mean follow-up of 6 years, 18% of patients had portal hypertension, 14.8% had hepatic failure and mortality rate was 14.8%.
  
  
  CONCLUSIONS
  Cholestasis of unknown aetiologies are frequent in our hospital. Poor prognosis, in our study, is due to delay to diagnosis and difficulties in medical and surgical management.
authors.affiliation: Hôpital d'Enfants, Bab Saadoun, Tunis, Tunisie.
authors.forename: Olfa
authors.initials: O
authors.lastname: Bouyahia
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Khelifi
authors.forename: Sonia Mrad
authors.initials: SM
authors.lastname: Mazigh
authors.forename: Lamia
authors.initials: L
authors.lastname: Gharsallah
authors.forename: Beji
authors.initials: B
authors.lastname: Chaouachi
authors.forename: Mourad
authors.initials: M
authors.lastname: Hamzaoui
authors.forename: Sihem
authors.initials: S
authors.lastname: Barsaoui
authors.forename: Sayda
authors.initials: S
authors.lastname: Ben Becher
authors.forename: Souad
authors.initials: S
authors.lastname: Bousnina
authors.forename: Samir
authors.initials: S
authors.lastname: Boukthir
authors.forename: Azza Sammoud
authors.initials: AS
authors.lastname: El Gharbi
mesh_terms: D002779:Cholestasis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D014416:Tunisia / Q000453:epidemiology