Liposomal doxorubicin in suspected ovarian carcinoma patient with very low creatinine clearance test value.
A 74-year-old woman presented with moderate ascites with diagnostic features of adenocarcinoma of the ovary. She was given 1 course of cisplatin- and paclitaxel-based chemotherapy but did not have her creatinine clearance tested, which was consequently found to be very low. She subsequently presented with gross debilitating symptoms and toxicity. However, she tolerated 20 mg/m(2) dose of liposomal doxorubicin every 4 weeks and was a good responder. Only 1 previous study of use of doxorubicin was found in such a low level of creatinine clearance.
Bose
Chinmoy K
CK
St. Bartholomew's Hospital, London, United Kingdom. ckbose@hotmail.com
Bose
Banani
B
Basu
Amit
A
Basu
Srabani
S
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000652:urine*; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D003404:Creatinine / Q000652:urine*; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis / Q000652:urine*; D008657:Metabolic Clearance Rate; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000652:urine*; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D003404:Creatinine