title: Involvement of insula and cingulate cortices in control and suppression of natural urges.
abstract: The physiology of control and suppression of natural urges is not well understood. We used [(15)O]H(2)O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.
authors.affiliation: Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. lernera@mail.nih.gov
authors.forename: Alicja
authors.initials: A
authors.lastname: Lerner
authors.forename: Anto
authors.initials: A
authors.lastname: Bagic
authors.forename: Takashi
authors.initials: T
authors.lastname: Hanakawa
authors.forename: Eilis A
authors.initials: EA
authors.lastname: Boudreau
authors.forename: Fernando
authors.initials: F
authors.lastname: Pagan
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Mari
authors.forename: William
authors.initials: W
authors.lastname: Bara-Jimenez
authors.forename: Murat
authors.initials: M
authors.lastname: Aksu
authors.forename: Susumu
authors.initials: S
authors.lastname: Sato
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Murphy
authors.forename: Mark
authors.initials: M
authors.lastname: Hallett
mesh_terms: D000328:Adult; D001767:Blinking / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004328:Drive; D005246:Feedback / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D007266:Inhibition, Psychological; D033182:Intention; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009433:Neural Inhibition / Q000502:physiology*; D055815:Young Adult