title: Clavulanic acid: a review.
abstract: Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces clavuligerus and is active against a wide spectrum of Gram-positive and Gram-negative bacteria. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of CA.
authors.affiliation: Food Engineering and Technology Department, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai 400 019, India.
authors.forename: Parag S
authors.initials: PS
authors.lastname: Saudagar
authors.forename: Shrikant A
authors.initials: SA
authors.lastname: Survase
authors.forename: Rekha S
authors.initials: RS
authors.lastname: Singhal
mesh_terms: D000818:Animals; D019818:Clavulanic Acid / Q000009:adverse effects / Q000096:biosynthesis / Q000737:chemistry / Q000627:therapeutic use; D003141:Communicable Diseases / Q000188:drug therapy; D005285:Fermentation; D006801:Humans
chemical_list: D019818:Clavulanic Acid