title: Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infection.
abstract: Invasive disease following methicillin-resistant Staphylococcus aureus (MRSA) detection is common, regardless of whether initial detection involves colonization or infection. We assessed the genetic relatedness of isolates obtained > or =2 weeks apart representing either repeated infections or colonization-infection sets to determine if infections are likely to be caused by previously harbored strains. We found that MRSA infection following initial colonization or infection is caused by the same strain in most cases, suggesting that a single successful attempt at decolonization may prevent the majority of later infection.
authors.affiliation: Division of Infectious Diseases, University of California Irvine School of Medicine, Orange, CA 92868, USA. susan.huang@uci.edu
authors.forename: Susan S
authors.initials: SS
authors.lastname: Huang
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: David K
authors.initials: DK
authors.lastname: Warren
authors.forename: Gianna
authors.initials: G
authors.lastname: Zuccotti
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Winokur
authors.forename: Shailesh
authors.initials: S
authors.lastname: Tendolkar
authors.forename: Linda
authors.initials: L
authors.lastname: Boyken
authors.forename: Rupak
authors.initials: R
authors.lastname: Datta
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Jones
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Ward
authors.forename: Tanya
authors.initials: T
authors.lastname: Aubrey
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Onderdonk
authors.forename: Christian
authors.initials: C
authors.lastname: Garcia
authors.forename: Richard
authors.initials: R
authors.lastname: Platt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D008297:Male; D016106:Methicillin Resistance / Q000235:genetics*; D008875:Middle Aged; D010802:Phylogeny; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification