Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT6 receptor ligands.
The synthesis of new pharmaceutically interesting 3-(2-N,N-diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield. Further sulfonylation of these novel indoles gave access to potential 5-HT(6) receptor ligands.
Alex
Karolin
K
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany.
Schwarz
Nicolle
N
Khedkar
Vivek
V
Sayyed
Iliyas Ali
IA
Tillack
Annegret
A
Michalik
Dirk
D
Holenz
Jörg
J
Díaz
José Luis
JL
Beller
Matthias
M
D017606:Chlorine Compounds / Q000737:chemistry; D005019:Ethyl Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D005021:Ethylamines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000378:metabolism*
D017606:Chlorine Compounds; D005019:Ethyl Ethers; D005021:Ethylamines; D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin