Quantitative trait loci mapping.
This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems.
Xiong
Dong-Hai
DH
Osteoporosis Research Center, Creighton University, Omaha, NE, USA.
Liu
Jian-Feng
JF
Guo
Yan-Fang
YF
Guo
Yan
Y
Yang
Tie-Lin
TL
Jiang
Hui
H
Chen
Yuan
Y
Yang
Fang
F
Recker
Robert R
RR
Deng
Hong-Wen
HW
D002874:Chromosome Mapping / Q000379:methods; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010375:Pedigree; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable