title: Results of the Predictors of Response to CRT (PROSPECT) trial.
abstract: BACKGROUND
  Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters to predict CRT response.
  
  
  RESULTS
  Fifty-three centers in Europe, Hong Kong, and the United States enrolled 498 patients with standard CRT indications (New York Heart Association class III or IV heart failure, left ventricular ejection fraction < or = 35%, QRS > or = 130 ms, stable medical regimen). Twelve echocardiographic parameters of dyssynchrony, based on both conventional and tissue Doppler-based methods, were evaluated after site training in acquisition methods and blinded core laboratory analysis. Indicators of positive CRT response were improved clinical composite score and > or = 15% reduction in left ventricular end-systolic volume at 6 months. Clinical composite score was improved in 69% of 426 patients, whereas left ventricular end-systolic volume decreased > or = 15% in 56% of 286 patients with paired data. The ability of the 12 echocardiographic parameters to predict clinical composite score response varied widely, with sensitivity ranging from 6% to 74% and specificity ranging from 35% to 91%; for predicting left ventricular end-systolic volume response, sensitivity ranged from 9% to 77% and specificity from 31% to 93%. For all the parameters, the area under the receiver-operating characteristics curve for positive clinical or volume response to CRT was < or = 0.62. There was large variability in the analysis of the dyssynchrony parameters.
  
  
  CONCLUSIONS
  Given the modest sensitivity and specificity in this multicenter setting despite training and central analysis, no single echocardiographic measure of dyssynchrony may be recommended to improve patient selection for CRT beyond current guidelines. Efforts aimed at reducing variability arising from technical and interpretative factors may improve the predictive power of these echocardiographic parameters in a broad clinical setting.
authors.affiliation: Lindner Clinical Trial Center, Cincinnati, OH 45219, USA. chunge@ohioheart.org
authors.forename: Eugene S
authors.initials: ES
authors.lastname: Chung
authors.forename: Angel R
authors.initials: AR
authors.lastname: Leon
authors.forename: Luigi
authors.initials: L
authors.lastname: Tavazzi
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Sun
authors.forename: Petros
authors.initials: P
authors.lastname: Nihoyannopoulos
authors.forename: John
authors.initials: J
authors.lastname: Merlino
authors.forename: William T
authors.initials: WT
authors.lastname: Abraham
authors.forename: Stefano
authors.initials: S
authors.lastname: Ghio
authors.forename: Christophe
authors.initials: C
authors.lastname: Leclercq
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Cheuk-Man
authors.initials: CM
authors.lastname: Yu
authors.forename: John
authors.initials: J
authors.lastname: Gorcsan
authors.forename: Martin
authors.initials: M
authors.lastname: St John Sutton
authors.forename: Johan
authors.initials: J
authors.lastname: De Sutter
authors.forename: Jaime
authors.initials: J
authors.lastname: Murillo
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000592:standards*; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index