title: Quantitative analysis in spontaneous canine anal sac gland adenomas and carcinomas.
abstract: Stained cytological specimens from 7 canine anal sac gland adenomas and 11 canine anal sac gland carcinomas were analyzed by computer-assisted nuclear morphometry. In each case, the nuclei of at least 100 neoplastic cells were measured, and the mean nuclear area (MNA), mean nuclear perimeter (MNP), mean nuclear diameter (MND) and nuclear roundness (NR) were calculated. The study aimed to evaluate (1) the possibility of using nuclear cytomorphometry as an auxiliary diagnostic method to differentiate between canine anal sac gland adenomas and adenocarcinomas, and (2) the prognostic value of nuclear morphometry in canine anal sac gland adenocarcinomas. The results indicated that (1) MNA, MNP, MND and NR could be used as effective auxiliary tools for differential diagnosis between canine anal sac gland adenomas and adenocarcinomas, and (2) MNA, MNP and MND are reliable prognostic indicators for canine anal sac gland adenocarcinomas.
authors.affiliation: Department of General and Clinical Pathology of Animals, Trakia University, 6000 Stara Zagora, Bulgaria.
authors.forename: Radostin
authors.initials: R
authors.lastname: Simeonov
authors.forename: Galina
authors.initials: G
authors.lastname: Simeonova
mesh_terms: D000694:Anal Gland Neoplasms / Q000473:pathology*; D000695:Anal Sacs / Q000473:pathology*; D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D013045:Species Specificity