[Stress ulcer prophylaxis in septic patients. Evidence-based overview].
In spite of decreasing incidence stress-related gastrointestinal bleeding is still an important problem in intensive care medicine. Especially patients with severe sepsis or septic shock are prone to develop lesions of the upper gastrointestinal tract with consecutive bleeding. In order to prevent gastrointestinal bleeding various pharmacological agents are used to either suppress gastric acid or neutralize its effect. The following article presents an update on important aspects of stress-related mucosal disease. It further reviews current literature to provide evidence-based recommendations for stress ulcer prophylaxis in septic patients.
Elke
Gunnar
G
Klinik für Anästhesiologie und Operative Intensivmedizin des Universitätsklinikums Schleswig-Holstein, Campus Kiel. elke@anaesthesie.uni-kiel.de
Schädler
Dirk
D
Zick
Günther
G
Scholz
Jens
J
Weiler
Norbert
N
D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000209:etiology*; D019317:Evidence-Based Medicine; D005744:Gastric Acid / Q000378:metabolism*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy / Q000209:etiology; D018805:Sepsis / Q000150:complications* / Q000523:psychology; D012772:Shock, Septic / Q000209:etiology; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology*; D013315:Stress, Psychological / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D002927:Cimetidine; D009853:Omeprazole