Proliferative effects of insulin analogues on mammary epithelial cells.
Structural modification of insulin results in the generation of insulin analogues that show altered binding affinities to the insulin receptor and/or IGF-I receptor. As a consequence these insulin analogues may have increased mitogenic potency. Nine benign or malignant human mammary epithelial cells, which show different insulin receptor and IGF-I receptor expression patterns, were studied regarding mitogenicity of insulin and insulin analogues. Only insulin glargine showed a significantly higher proliferative effect on MCF-7 breast cancer cells compared to regular insulin among a panel of short- or long-acting insulin analogues, that are in clinical use.
Mayer
Doris
D
Hormones and Signal Transduction, German Cancer Research Centre, Heidelberg, Germany. d.mayer@dkfz.de
Shukla
Ashish
A
Enzmann
Harald
H
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology* / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000187:drug effects; D042361:Mammary Glands, Human / Q000166:cytology* / Q000187:drug effects; D017526:Receptor, IGF Type 1 / Q000378:metabolism
D007328:Insulin; D017526:Receptor, IGF Type 1