Translational control: a new dimension in embryonic stem cell network analysis.
Systems biology studies have revealed transcriptional networks and proteomic signatures critical for embryonic stem cell (ESC) function. In this issue of Cell Stem Cell, Sampath et al. (2008) demonstrate that translation is also differentially controlled in undifferentiated versus differentiated ESCs.
Chang
Wing Y
WY
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Stanford
William L
WL
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D051379:Mice; D040081:Protein Array Analysis; D014176:Protein Biosynthesis; D046188:Protein Modification, Translational / Q000235:genetics; D040901:Proteomics
D048868:Adaptor Proteins, Signal Transducing