title: Muscle wastage in heart failure: orphan of the heart failure.
abstract: The patients with heart failure (HF) often exhibit some degree of muscle wasting restricted to the lower limbs. This loss of tissue may become more extensive in some patients, usually when their HF is more advanced, and may affect all body compartments. The underlying metabolic causes are very complex and differ from patient to patient. Three essential contributors are dietary deficiency and loss of nutrients through the digestive tract and metabolic dysfunction. The development of cachexia is an ominous sign and new drugs will be added into our therapeutic armamentarium to fight against cardiac cachexia in the near-future.
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
authors.forename: Murat
authors.initials: M
authors.lastname: Celik
authors.forename: U Cagdas
authors.initials: UC
authors.lastname: Yuksel
authors.forename: Ersoy
authors.initials: E
authors.lastname: Isik
mesh_terms: D002100:Cachexia / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D006333:Heart Failure / Q000150:complications* / Q000378:metabolism; D006801:Humans; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*