Microbial transformation of the diterpene mulin-11,13-dien-20-oic acid by Mucor plumbeus.
Two new mulinane-type derivatives: 16-hydroxy mulin-11,13-dien-20-oic (2) acid and 7alpha,16-dihydroxy mulin-11,13-dien-20-oic (3) acid were obtained by microbial transformation of mulin-11,13-dien-20-oic acid (1), along with tyrosol (4) using liquid cultures of Mucor plumbeus. The latter compound has not been previously identified in the genus Mucor. Structural elucidation of these metabolites was achieved using 1D- and 2D-NMR spectroscopy.
Areche
Carlos
C
Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile.
Loyola
Luis A
LA
Borquez
Jorge
J
Rovirosa
Juana
J
San-Martin
Aurelio
A
D019661:Apiaceae / Q000737:chemistry*; D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000254:growth & development / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry
C530407:16-hydroxymulin-11,13-dien-20-oic acid; C530408:7alpha,16-dihydroxymulin-11,13-dien-20-oic acid; D004224:Diterpenes; C530406:mulin-11,13-dien-20-oic acid