title: A clinical electrophysiological study of emotional lability in patients with systemic lupus erythematosus.
abstract: Neuropsychiatric symptoms are well recognized in systemic lupus erythematosus (SLE), with depression and anxiety often reported. The authors' clinical observations suggested emotional lability might also be a noteworthy symptom. In a consecutive series of systemic lupus erythematosus clinic attendees the authors therefore measured depression, anxiety, and emotional lability. Additionally, based on reports linking emotional reactivity and transient mood changes to alterations in early attentional processes, the authors investigated event-related potential indices of preattentive and early orienting responses to auditory stimuli (N1, MMN, P3a and P3b). The authors observed that 15 of 32 participants with systemic lupus erythematosus had high lability scores and, comparing event-related potential measures between the high and low lability subgroups, noted that those with greater emotional lability demonstrated reduced response latencies in N1 and MMN paradigms.
authors.affiliation: Department of Psychiatry at the University of Freiburg, Freiburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Langosch
authors.forename: Stacey
authors.initials: S
authors.lastname: Rand
authors.forename: Boyd
authors.initials: B
authors.lastname: Ghosh
authors.forename: Simeran
authors.initials: S
authors.lastname: Sharma
authors.forename: Colin
authors.initials: C
authors.lastname: Tench
authors.forename: Richard
authors.initials: R
authors.lastname: Stratton
authors.forename: David
authors.initials: D
authors.lastname: D'Cruz
authors.forename: Michael
authors.initials: M
authors.lastname: Trimble
authors.forename: Geoff
authors.initials: G
authors.lastname: Barrett
authors.forename: Howard
authors.initials: H
authors.lastname: Ring
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000342:Affective Symptoms / Q000209:etiology*; D000704:Analysis of Variance; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004644:Emotions / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011930:Reaction Time