title: QT dispersion at rest and during adenosine stress myocardial perfusion imaging correlation with Myocardial Jeopardy Score.
abstract: BACKGROUND
  The usefulness of QT dispersion (QTd) during adenosine myocardial perfusion imaging (MPI) to predict severity of coronary artery disease (CAD) has not been studied.
  
  
  METHODS
  Eighty-eight patients referred for diagnostic cardiac catheterization after abnormal MPI were included. Thirty-four patients with no stenosis (Duke Score = 0) were included in Group 1, and 54 patients with significant CAD (Duke Score > or = 2) formed Group 2. Resting and stress QTd and prolongation in QTd (delta QTd) were measured and evaluated as independent predictors for severity of CAD.
  
  
  RESULTS
  Resting QTd was higher in Group 2 as compared with Group 1. During peak infusion of adenosine, QTd was significantly prolonged in Group 1 but remained unchanged, or fixed, in Group 2. In addition, in patients with significant CAD, resting QTd positively correlated with the Duke Score. On multiple regression analysis; independent predictors for significant CAD (odds ratio [OR], 95% confidence interval [CI], p-value) were resting QTd (4.9, 95% CI 1.1-21.6, < 0.05 for fourth Quartile compared with first Quartile) and delta QTd (4.0, 1.4-11.2, < 0.01 for first and second Quartiles compared with third and fourth Quartiles).
  
  
  CONCLUSIONS
  In patients with abnormal stress MPI, prolonged resting QTd, and fixation of QTd during stress are independent predictors of significant CAD. In addition, resting QTd correlate with the Duke Jeopardy Score and therefore, may have independent prognostic value.
authors.affiliation: Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pradhan
authors.forename: H
authors.initials: H
authors.lastname: Vankayala
authors.forename: A
authors.initials: A
authors.lastname: Niraj
authors.forename: P
authors.initials: P
authors.lastname: Kumaravelu
authors.forename: M
authors.initials: M
authors.lastname: Trivedi
authors.forename: D
authors.initials: D
authors.lastname: Thatai
authors.forename: L
authors.initials: L
authors.lastname: Afonso
mesh_terms: D000241:Adenosine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D011237:Predictive Value of Tests; D012146:Rest / Q000502:physiology; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D000241:Adenosine