[Detection of clostridia toxin markers in different types of the course of acute intestinal infections].
The purpose of the investigation was to study the detection rates of markers and the level of C. diffcile A and B toxins and C. perfringens type A enterotoxin in patients with acute intestinal infections (AII). Two hundred and seventy-three patients with AII of varying etiology were followed up. According to the clinical syndrome, the patients were divided into 3 groups: (1) patients with the gastroenteritic (GE) type; (2) those with the gastroenterocolitic (GEC) type; (3) those with enterocolitic (EC) type. The circulation of markers of C. difficile A and B toxins and C. perfringens type A enterotoxin was studied, by employing the immunological test systems in the coagglutination test using the plates. The higher levels of antigens of all toxins were identified in the acute period of the disease in the GE and EC types than in the GEC type. There was a short increase in the levels of antigens of the test toxins in the GEC type and a gradual decrease in the GE and EC types. By discharge from hospital, the markers of toxins (more commonly of C. diffcile A) were preserved in 16.4% of the patients mainly in the GEC type.
Giulazian
N M
NM
Belaia
O F
OF
Belyĭ
Iu F
IuF
Pak
S G
SG
D000208:Acute Disease; D001427:Bacterial Toxins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000097:blood* / Q000382:microbiology; D003016:Clostridium perfringens; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000097:blood* / Q000382:microbiology; D008297:Male
D001427:Bacterial Toxins; D015415:Biomarkers