title: In vitro and in vivo investigations on the binary meloxicam-mannitol system.
abstract: The objective of the study in rats was to investigate the anti-inflammatory effects of pure meloxicam (ME) with different particle sizes and of physical mixtures of the binary ME-mannitol system. The level of local inflammation was significantly decreased when the amount of mannitol was the highest and the particle size of ME was the lowest as well as the components had the interparticulate interaction. The same results were achieved in in vitro experiments.
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Hungary.
authors.forename: P Reisi
authors.initials: PR
authors.lastname: Nassab
authors.forename: G
authors.initials: G
authors.lastname: Blazsó
authors.forename: T
authors.initials: T
authors.lastname: Nyári
authors.forename: G
authors.initials: G
authors.lastname: Falkay
authors.forename: P
authors.initials: P
authors.lastname: Szabó-Révész
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D002351:Carrageenan; D002626:Chemistry, Pharmaceutical; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D008353:Mannitol / Q000737:chemistry* / Q000494:pharmacology; D000077239:Meloxicam; D010316:Particle Size; D051381:Rats; D012995:Solubility; D013843:Thiazines / Q000737:chemistry* / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D008353:Mannitol; D002351:Carrageenan; D000077239:Meloxicam