PIKK-ing a new partner: a new role for PKB in the DNA damage response.
The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-damaging agents, such as ionizing radiation. In a recent paper published in Molecular Cell, Hemmings and colleagues provide evidence that DNA-PK is required for the activation of PKB in response to exposure to ionizing radiation, suggesting that these two protein kinases may act together to promote survival after DNA damage.
Lees-Miller
Susan P
SP
Department of Biochemistry & Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada. leesmill@ucalgary.ca
D002135:Calcium-Binding Proteins / Q000378:metabolism; D002455:Cell Division; D002470:Cell Survival; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism* / Q000502:physiology
C109198:CIB1 protein, human; D002135:Calcium-Binding Proteins; D051057:Proto-Oncogene Proteins c-akt