title: The actin binding protein, fesselin, is a member of the synaptopodin family.
abstract: Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively unfolded proteins, fesselin has multiple binding partners including actin, myosin, calmodulin and alpha-actinin. Fesselin accelerates actin polymerization and bundles actin. These and other observations suggest that fesselin is a component of the cytoskeleton. We have now cloned fesselin and have determined the cDNA derived amino acid sequence. We verified parts of the sequence by Edman analysis and by mass spectroscopy. Our results confirmed fesselin is homologous to human synaptopodin 2 and belongs to the synaptopodin family of proteins.
authors.affiliation: Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, 600 Moye Blvd, Greenville, NC 27834, USA. schroeterm@ecu.edu
authors.forename: Mechthild M
authors.initials: MM
authors.lastname: Schroeter
authors.forename: Brent
authors.initials: B
authors.lastname: Beall
authors.forename: Hans W
authors.initials: HW
authors.lastname: Heid
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Chalovich
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics*; D008840:Microfilament Proteins / Q000737:chemistry* / Q000235:genetics*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid; D014422:Turkeys
chemical_list: D030161:Avian Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010455:Peptides; C503979:SYNPO2 protein, human; C443099:fesselin