[Atypical antipsychotics in elderly patients with dementia].
Antipsychotic medication is often prescribed to persons with dementia exhibiting behavioural and psychological symptoms (BPSD). Use of atypical antipsychotics in elderly persons with dementia is associated with an increased risk of serious cerebrovascular adverse events and increased mortality. Based on a review of available literature, we conclude that atypical antipsychotics have a modest effect on BPSD and potentially serious side effects and that conventional antipsychotics appear to have even less favourable effects and adverse event profiles. Antipsychotic medication in patients with dementia exhibiting BPSD should only be prescribed for short-term treatment of severe symptoms associated with considerable distress or serious risk. Non-pharmacological interventions should be the first-line treatment approach in most cases.
Selbaek
Geir
G
Alderspsykiatrisk kompetansesenter, Sykehuset Innlandet, Postboks 68, 2312 Ottestad. geir.selbaek@aldringoghelse.no
Engedal
Knut
K
D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D003704:Dementia / Q000188:drug therapy* / Q000523:psychology; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008728:Methotrimeprazine / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D000077152:Olanzapine; D012307:Risk Factors; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use; D020521:Stroke / Q000139:chemically induced
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D008728:Methotrimeprazine; D006220:Haloperidol; D018967:Risperidone; D000077152:Olanzapine