Synthesis of novel liquid crystal compounds and their blood compatibility as anticoagulative materials.
The objective of this study was to synthesize new types of cholesteric liquid crystal compounds and study the anticoagulative properties of their composite membranes. Three kinds of cholesteric liquid crystal compounds were synthesized and characterized by infrared spectroscopy, differential scanning calorimetry and optical polarizing microscope. The polysiloxane, as a substrate, was blended with three liquid crystal compounds and was then used as membranes. The anticoagulative property of different polysiloxane liquid crystal composite membranes was identified by the blood compatibility tests. Three cholesteryl liquid crystals synthesized in this work contained hydrophilic soft chains and presented iridescent texture owned by cholesteric liquid crystals in the range of their liquid crystal state temperature, but only cholesteryl acryloyl oxytetraethylene glycol carbonate was in the liquid crystal state at body temperature. When liquid crystals were blended with polysiloxane to form polysiloxane/liquid crystal composite membranes, the haemocompatibility of these membranes could be improved to some extent. The blood compatibility of composite membranes whose hydrophilic property was the best was more excellent than that of other composite membranes, fewer platelets adhered and spread, and showed little distortion on the surface of materials.
Tu
Mei
M
Department of Material Science and Engineering, Jinan University, Guangzhou, 510632, People's Republic of China. tumei@jnu.edu.cn
Cha
Zhen-Gang
ZG
Feng
Bo-Hua
BH
Zhou
Chang-Ren
CR
D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D050866:Liquid Crystals / Q000737:chemistry*; D008422:Materials Testing; D010973:Platelet Adhesiveness / Q000187:drug effects*
D000925:Anticoagulants; D001672:Biocompatible Materials