Acute interstitial nephritis induced by intermittent use of rifampicin in patient with brucellosis.
Acute oliguric renal failure (ARF) developed in a patient 2 days after she was started on intermittent anti-Brucella therapy including rifampicin. The clinical picture was compatible with acute allergic interstitial nephritis. Renal histology revealed mainly acute tubular necrosis with mild tubulo-interstitial mononuclear cellular infiltrate. Intermittent therapy, as in our patient, has been the major factor in the development of rifampicin induced ARF in cases reviewed in literature.
Salih
S Bin
SB
Division of Internal Medicine, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. salihbinsalih@hotmail.com
Kharal
M
M
Qahtani
M
M
Dahneem
L
L
Nohair
S
S
D000208:Acute Disease; D002006:Brucellosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*
D012293:Rifampin