Renal artery stenosis in chronic renal failure: caution is advised for percutaneous revascularization.
BACKGROUND
Percutaneous intervention for renal artery stenosis may lead to acute deterioration of renal function and, consequently, of a patient's well-being. The purpose of this study was to determine whether selection by indication for renal artery stenosis was predictive of outcome.


METHODS
All patients who underwent intervention for renal artery stenosis were selected to participate in the study and their indication for intervention was determined. Patient characteristics, i.e., renal function and clearance by modified diet in renal disease (MDRD), blood pressure and its treatment, kidney size, proteinuria, and cardiovascular events, were recorded before intervention, at 1 year, and at the end of follow-up. An intervention was classified as a success, no change, or a failure with respect to the indication for intervention. Successful interventions were compared to failures with respect to indication and patient characteristics.


RESULTS
Twenty-four patients were included in the study: 11 for renal failure (RF), 9 for hypertension (HT), and 4 due to flash pulmonary edema (FPE). One patient with RF, four with HT, and one with FPE benefited from intervention. Nine patients with RF and two with HT were classified as failures. Failure was most prevalent in the RF group (p<0.05). Other predictors of failure were older age (p<0.02), worse renal function (p<0.02), smaller kidneys (p<0.03), and previous cardiovascular events (p<0.05).


CONCLUSIONS
Renal failure must be considered a contraindication for intervention in renal artery stenosis. Intervention can be considered in FPE and hypertension, provided other predictive factors for failure are absent.
Wierema
Thomas K A
TK
Department of Internal Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands. twie@sint.azm.nl
Yaqoob
Mohammed M
MM
D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000150:complications* / Q000628:therapy*; D016896:Treatment Outcome