Flow cytometry and morphology analysis of bone marrow in a child with brucellosis and hematologic manifestations.
Constitutional symptoms and pancytopenia are occasionally the initial presentation of pediatric brucellosis. Therefore, in endemic areas, in children with pancytopenia, both brucellosis and malignancy should be included in the deferential diagnosis. We report here a child with pancytopenia and hepatosplenomegaly as manifestations of brucellosis in whom bone marrow morphology and flow cytometry data revealed hemophagocytosis, left shift in myeloid cells and activation changes in antigenic properties of T and B lymphocytes and monocytes. The patient had an uneventful and complete recovery after appropriate antibiotic therapy. Our report demonstrates that bone marrow and flow cytometry findings in children with brucellosis may include significant reactive changes in hematopoiesis.
Broides
Arnon
A
Pediatric Emergency Department, Soroka University Medical Center, Beer-Sheva, Israel. broides@bgu.ac.il
Shubinsky
George
G
Yermiahu
Tikva
T
Abu-Quider
Abed
A
Press
Joseph
J
Moser
Asher
A
D015703:Antigens, CD / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology*; D002006:Brucellosis / Q000150:complications* / Q000473:pathology*; D002648:Child; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood; D006529:Hepatomegaly / Q000209:etiology / Q000276:immunology; D006801:Humans; D010198:Pancytopenia / Q000209:etiology* / Q000276:immunology; D013163:Splenomegaly / Q000209:etiology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D006684:HLA-DR Antigens