Genetic heterogeneity and trans regulators of gene expression.
Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage.
Bastone
Laurel A
LA
Division of Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA. lbastone@alumni.upenn.edu
Putt
Mary E
ME
Ten Have
Thomas R
TR
Cheung
Vivian G
VG
Spielman
Richard S
RS