title: Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation.
abstract: The treatment outcome for infant acute lymphoblastic leukemia (ALL) with positive MLL gene rearrangements remains poor. We analyzed whether additional chromosomal abnormalities (ACA) other than 11q23 translocation could affect the disease behavior and its prognosis. Eighteen of seventy-four patients with infant acute lymphoblastic leukemia showed ACA, including three-way translocations in four, other novel translocations in four, and complex structural chromosomal changes in four. Only age less than 6 months and positive central nervous system leukemia were significant prognostic factors by multivariate analysis. However, overall survival rates were worse in patients with ACA compared to those with non-ACA. Genetic alterations induced by additional chromosomal changes may be associated with disease progression and poorer overall survival rates in infants with MLL-rearranged ALL.
authors.affiliation: Department of Pediatrics, Ehime University, Toon, Ehime, Japan.
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Tauchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomizawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Eguchi
authors.forename: Minenori
authors.initials: M
authors.lastname: Eguchi-Ishimae
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Koh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirayama
authors.forename: Noriko
authors.initials: N
authors.lastname: Miyamura
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinukawa
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Keizo
authors.initials: K
authors.lastname: Horibe
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D018572:Disease-Free Survival; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase