[Acute generalized exanthematous pustulosis induced by omeprazole].
Acute generalized exanthematous pustulosis (AGEP) comprises a group of eruptions characterized by several small sterile pustules over an erythematous-edematous skin. These eruptions are usually drug induced and show some characteristics that suggest an immunologic background. Treatment is based on withdrawal of the drug causing the eruption. Prognosis is generally good and the skin lesions usually resolve in a few days with characteristic postpustular pin-point desquamation. We report three cases of AGEP induced by omeprazole, a drug with a good safety profile. Some adverse cutaneous reactions have been described as secondary effects. However, to our knowledge, no cases of omeprazole-induced AGEP have previously been reported. AGEP related to other proton pump inhibitors is exceptional.
Nantes Castillejo
Oscar
O
Servicio de Aparato Digestivo, Hospital de Navarra, Pamplona, Navarra, España. onantes@yahoo.es
Zozaya Urmeneta
José Manuel
JM
Valcayo Peñalba
Ana
A
Martínez-Peñuela Virseda
José María
JM
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D003875:Drug Eruptions / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects*; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
D054328:Proton Pump Inhibitors; D009853:Omeprazole