title: Antitussive stemoninine alkaloids from the roots of Stemona tuberosa.
abstract: Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a- O-methylstemoenonine (2), oxystemoenonine (3), 1,9a- seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Li-Gen
authors.initials: LG
authors.lastname: Lin
authors.forename: Kan Man
authors.initials: KM
authors.lastname: Li
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Tang
authors.forename: Chang-Qiang
authors.initials: CQ
authors.lastname: Ke
authors.forename: John A
authors.initials: JA
authors.lastname: Rudd
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000996:Antitussive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003371:Cough / Q000188:drug therapy; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006168:Guinea Pigs; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal