title: Quantitative trait loci mapping.
abstract: This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems.
authors.affiliation: Osteoporosis Research Center, Creighton University, Omaha, NE, USA.
authors.forename: Dong-Hai
authors.initials: DH
authors.lastname: Xiong
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Tie-Lin
authors.initials: TL
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Robert R
authors.initials: RR
authors.lastname: Recker
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Deng
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010375:Pedigree; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable