title: A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus strain.
abstract: A new diketopiperazine alkaloid containing the uncommon amino acid L-7, 9-dihydroxy-8-methoxyphenylalanine (1), has been isolated from the algicolous Aspergillus flavus strain. The structure of 1 including the absolute stereochemistry was determined by spectroscopic data and chemical means. Compound 1 showed weak cytotoxicity against HL-60 cell lines with an IC50 value of 36.5 microg/ml.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Aiqun
authors.initials: A
authors.lastname: Lin
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Fang
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001231:Aspergillus flavus / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D054659:Diketopiperazines / Q000737:chemistry* / Q000302:isolation & purification; D005285:Fermentation; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000596:Amino Acids; D054659:Diketopiperazines