[Infection of macrophages with tick-borne encephalitis virus].
Virological and morphological studies have established that tick-borne encephalitis (TBE) from virus-containing liquid is able to adhere to the surface of macrophages, to penetrate, and to multiple in them. Viral particles come into and out through local macrophageal plasmolemma lysis. The type of macrophageal infection is considered to be autonomic as genomic activation and TBE reproduction occurred in the cell cytoplasm. Productive acute lytic infection in the macrophages was due to the appearance of reproduction-induced adequate TBE with a pronounced cytopathic effect on cultured porcine embryo kidney cells and to the synthesis of virus-specific and virus-induced cytoplasmic organelles that caused cell deaths upon toxic and mechanical exposure.
Plekhova
N G
NG
Somova
L M
LM
Krylova
N V
NV
Leonova
G N
GN
Pustovalov
E V
EV
D000818:Animals; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D003593:Cytoplasm / Q000648:ultrastructure / Q000821:virology; D004669:Encephalitis Viruses, Tick-Borne / Q000302:isolation & purification / Q000502:physiology*; D004675:Encephalitis, Tick-Borne / Q000821:virology*; D017737:Macrophages, Peritoneal / Q000648:ultrastructure / Q000821:virology*; D051379:Mice; D008854:Microscopy, Electron; D013552:Swine; D014779:Virus Replication