5-HT2A receptor gene polymorphism and negative symptoms in first episode (drug-naive) Chinese Han nationality individuals with schizophrenia.
OBJECTIVE
To investigate whether the 5-hydroxytryptamine 2A receptor (5-HT2A) gene T102C polymorphism is associated with the severity symptoms and negative symptoms in the first episode Chinese Han nationality patients with schizophrenia.


METHODS
Altogether 201 first episode Chinese Han nationality patients with schizophrenia were enrolled in this study. Genotyping of 5-HT2A gene T102C polymorphism was performed by PCR-RFLP technique. The positive and negative Symptom Scale (PANSS) was used for the evaluation of the severity of psychotic symptoms before any drug treatment.


RESULTS
5-HT2A receptor 102-T/T genotype was significantly associated with both the PANSS total and negative symptom subscale baseline scores before the treatment, but not with the positive and general psychopathology subscales.


CONCLUSIONS
5-HT2A T102C functional polymorphism may play a role in negative symptoms and prognosis of Chinese Han nationality people with schizophrenia.
Wang
Yu-hong
YH
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
Li
Wen-qiang
WQ
Huang
Zhao
Z
Shi
Yu-zhong
YZ
Wang
Xu-Yi
XY
Huang
Jin-song
JS
Zhou
Xu-hui
XH
Chen
Hong-xian
HX
Hao
Wei
W
D000293:Adolescent; D000328:Adult; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A