title: Treating the physical symptoms of depression with second-generation antidepressants: a systematic review and metaanalysis.
abstract: BACKGROUND
  Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes.
  
  
  OBJECTIVE
  The authors reviewed the effect of newer antidepressants on pain in patients with depression.
  
  
  METHODS
  The authors searched systematically for trials of second-generation antidepressants that enrolled depression patients and reported pain outcomes, pooling changes on the pain visual-analog scale (VAS), using random-effects models.
  
  
  RESULTS
  Eight trials were eligible. Pooled analysis of head-to-head trials showed no difference in VAS between duloxetine and paroxetine. Both drugs were superior to placebo.
  
  
  CONCLUSIONS
  The authors found insufficient evidence to support the choice of one second-generation antidepressant over another in patients with pain accompanying depression.
authors.affiliation: Center on Implementing Evidence-Based Practice, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA. krebse@iupui.edu
authors.forename: Erin E
authors.initials: EE
authors.lastname: Krebs
authors.forename: Bradley N
authors.initials: BN
authors.lastname: Gaynes
authors.forename: Gerald
authors.initials: G
authors.lastname: Gartlehner
authors.forename: Richard A
authors.initials: RA
authors.lastname: Hansen
authors.forename: Patricia
authors.initials: P
authors.lastname: Thieda
authors.forename: Laura C
authors.initials: LC
authors.lastname: Morgan
authors.forename: Angela
authors.initials: A
authors.lastname: DeVeaugh-Geiss
authors.forename: Kathleen N
authors.initials: KN
authors.lastname: Lohr
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D000068736:Duloxetine Hydrochloride; D006304:Health Status; D006801:Humans; D010146:Pain / Q000175:diagnosis* / Q000453:epidemiology*; D010147:Pain Measurement; D017374:Paroxetine / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D013876:Thiophenes; D017374:Paroxetine; D000068736:Duloxetine Hydrochloride