title: Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx.
abstract: Isoprenylcysteine carboxyl methyltransferase (Icmt) is enzyme target in anticancer drug discovery. An Icmt natural product high-throughput screening campaign was conducted and a hit extract from the roots of Hovea parvicalyx was identified. 2'-Methoxy-3'-prenyl-licodione and 2'-methoxy-3',3''-diprenyl-licodione, two prenylated beta-hydroxychalcone compounds, together with the known flavanone (S)-glabrol, were isolated and identified as bioactive constituents. Their structures were determined largely by 1D and 2D NMR spectroscopy.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fechner
authors.forename: Anthony
authors.initials: A
authors.lastname: Boyle
authors.forename: Moana
authors.initials: M
authors.lastname: Simpson
authors.forename: Rama
authors.initials: R
authors.lastname: Addepalli
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Paul I
authors.initials: PI
authors.lastname: Forster
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Guymer
authors.forename: Tony
authors.initials: T
authors.lastname: Cheung
authors.forename: Huwei
authors.initials: H
authors.lastname: Chen
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011496:Protein Methyltransferases; C056501:protein-S-isoprenylcysteine O-methyltransferase