Molecular profiling in the diagnosis and treatment of high grade sarcomas.
High-density microarrays are used to measure in a comprehensive manner large-scale ("profile") gene expression patterns (when tumor RNA is tested) or gene copy number changes (when tumor genomic DNA is tested). Microarray-based studies are increasingly useful in addressing a wide variety of questions in sarcoma biology. This review includes a brief description of the microarray methodology and data analysis, followed by few examples of the recent applications of gene expression in the diagnosis, classification, and treatment of sarcomas.
Antonescu
Cristina R
CR
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. antonesc@mskcc.org
D004273:DNA, Neoplasm / Q000032:analysis; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D046228:Microarray Analysis / Q000379:methods*; D012334:RNA, Neoplasm / Q000032:analysis; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm