Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study.
OBJECTIVE
We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes.


METHODS
Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years.


RESULTS
Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men.


CONCLUSIONS
The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.
Fox
Caroline S
CS
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. foxca@nhlbi.nih.gov
Pencina
Michael J
MJ
Wilson
Peter W F
PW
Paynter
Nina P
NP
Vasan
Ramachandran S
RS
D'Agostino
Ralph B
RB
D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D048909:Diabetes Complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D018570:Risk Assessment; D013997:Time Factors