title: Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels.
abstract: The lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) expressed on vascular cells plays a major role in atherogenesis by internalizing and degrading oxidized low-density lipoprotein. LOX-1 can be cleaved from the cell surface and released as soluble LOX-1 (sLOX-1), and elevated sLOX-1 levels may be indicative of atherosclerotic plaque instability. We examined associations between the LOX-1 gene 3'UTR-C/T and G501C polymorphisms and plasma sLOX-1 levels in 97 healthy older men and women. The frequencies for the 3'UTR-T and 501C alleles were 46 and 10%, respectively. Plasma sLOX-1 levels were significantly higher in the 3'UTR CC genotype group compared with both the CT (P=0.02) and TT genotype groups (P=0.002). Plasma sLOX-1 levels were also significantly higher in the 501GC genotype group compared with the GG genotype group (P=0.004). In univariate analyses, sLOX-1 levels were significantly associated with both the 3'UTR-C/T and G501C polymorphisms. These associations remained significant after adjusting for age, sex, race and body mass index. In conclusion, variation in the LOX-1 gene is associated with plasma sLOX-1 levels in older men and women.
authors.affiliation: Department of Kinesiology, University of Maryland, College Park, MD 20742, USA. tiellis@wfubmc.edu
authors.forename: Tina E
authors.initials: TE
authors.lastname: Brinkley
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kume
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Mitsuoka
authors.forename: Michael D
authors.initials: MD
authors.lastname: Brown
authors.forename: Dana A
authors.initials: DA
authors.lastname: Phares
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
authors.forename: James M
authors.initials: JM
authors.lastname: Hagberg
mesh_terms: D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051127:Scavenger Receptors, Class E / Q000097:blood* / Q000235:genetics*
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E