Fluorinated analogs of malachite green: synthesis and toxicity.
A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.
Kraus
George A
GA
Iowa State University Department of Chemistry, Ames, IA 50011, USA. gakraus@iastate.edu
Jeon
Insik
I
Nilsen-Hamilton
Marit
M
Awad
Ahmed M
AM
Banerjee
Jayeeta
J
Parvin
Bahram
B
D002460:Cell Line; D005461:Fluorine / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D012394:Rosaniline Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013057:Spectrum Analysis
D012394:Rosaniline Dyes; C005095:malachite green; D005461:Fluorine