title: Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis.
abstract: The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of disease activity and bone turnover were registered in 343 postmenopausal women, 100 premenopausal women and 108 men with RA. Osteoporosis was found in a significantly higher percentage in postmenopausal women (55.7%) and in men (50.5%) in comparison with premenopausal women (18%; P < 0.001). The following risk factors for osteoporosis were found: older age, low BMI and high cumulative glucocorticoid dose in postmenopausal women, low BMI and high cumulative glucocorticoid dose in men and low BMI in premenopausal women. There is a very high prevalence of osteoporosis not only in postmenopausal women but also in men with RA. Osteoporosis risk factors are strongly dependent from gender and menopausal state.
authors.affiliation: Division of Rheumatology and Osteology, Department of Internal Medicine III, Friedrich-Schiller University of Jena, Erlanger Allee 101, 07740 Jena, Germany. peter.oelzner@med.uni-jena.de
authors.forename: Peter
authors.initials: P
authors.lastname: Oelzner
authors.forename: Antje
authors.initials: A
authors.lastname: Schwabe
authors.forename: Gabriele
authors.initials: G
authors.lastname: Lehmann
authors.forename: Thorsten
authors.initials: T
authors.lastname: Eidner
authors.forename: Sybille
authors.initials: S
authors.lastname: Franke
authors.forename: Gunter
authors.initials: G
authors.lastname: Wolf
authors.forename: Gert
authors.initials: G
authors.lastname: Hein
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D015519:Bone Density; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*; D015663:Osteoporosis, Postmenopausal / Q000209:etiology; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
chemical_list: D005938:Glucocorticoids