Studies directed toward the total synthesis of lancifodilactone G: an expeditious route to the ABC subunit.
An efficient entry to the ABC network of lancifodilactone G is outlined. The C ring is constructed by way of enyne ring-closing metathesis. The AB component is established via a base-mediated biomimetic oxy-Michael addition--lactonization sequence.
Paquette
Leo A
LA
Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA. paquette@chemistry.ohio-state.edu
Lai
Kwong Wah
KW
D017665:Hydroxyl Radical / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry
D014315:Triterpenes; C507939:lancifodilactone G; D017665:Hydroxyl Radical