Sialoglycotherapeutics in protozoal diseases.
The manipulation of glycosylation, mainly sialylation, holds enormous potential for understanding the biological functions of glycoproteins and glycolipids to treat many diseases. The existing knowledge in the field of glycobiology is exploited by glycotherapeutics for combating protozoan diseases. This review focuses on the development of novel glycobiological therapeutic strategies in the field of protozoan infections.
Ghoshal
Angana
A
Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India.
Mukhopadhyay
Sumi
S
Mandal
Chitra
C
D000818:Animals; D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D005657:Fungal Vaccines / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D005818:Genetic Engineering; D006001:Glycoconjugates / Q000378:metabolism; D006017:Glycolipids / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D010961:Plasmodium / Q000276:immunology; D011528:Protozoan Infections / Q000188:drug therapy* / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*
D004791:Enzyme Inhibitors; D005657:Fungal Vaccines; D006001:Glycoconjugates; D006017:Glycolipids; D006023:Glycoproteins; D012794:Sialic Acids