Cell-matrix adhesion: the Wech connection.
Integrins link the extracellular matrix to the cytoskeleton via a complex of proteins: the integrin-cytoskeleton link. A recent study in Drosophila has uncovered a new component of the link, Wech, and shown that it is essential for integrin-mediated adhesion.
Delon
Isabelle
I
Gurdon Institute of Cancer and Developmental Biology, and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Brown
Nick
N
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D016023:Integrins / Q000378:metabolism*
D002352:Carrier Proteins; D029721:Drosophila Proteins; D016023:Integrins; C528683:Wech protein, Drosophila