title: Biochemistry of Tau in Alzheimer's disease and related neurological disorders.
abstract: Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin dimers and stabilize microtubules. Tau is strongly expressed in neurons, localized in the axon and is essential for neuronal plasticity and network. From the very beginning of Tau discovery, proteomics methods have been essential to the knowledge of Tau biochemistry and biology. In this review, we have summarized the main contributions of several proteomic methods in the understanding of Tau, including expression, post-translational modifications and structure, in both physiological and pathophysiological aspects. Finally, recent advances in proteomics technology are essential to develop further therapeutic targets and early predictive and discriminative diagnostic assays for Alzheimer's disease and related disorders.
authors.affiliation: Inserm, U837, place de Verdun, 59045 Lille, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sergeant
authors.forename: Alexis
authors.initials: A
authors.lastname: Bretteville
authors.forename: Malika
authors.initials: M
authors.lastname: Hamdane
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Caillet-Boudin
authors.forename: Pierre
authors.initials: P
authors.lastname: Grognet
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bombois
authors.forename: David
authors.initials: D
authors.lastname: Blum
authors.forename: André
authors.initials: A
authors.lastname: Delacourte
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.forename: Eugeen
authors.initials: E
authors.lastname: Vanmechelen
authors.forename: Susanna
authors.initials: S
authors.lastname: Schraen-Maschke
authors.forename: Luc
authors.initials: L
authors.lastname: Buée
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D020033:Protein Isoforms; D011499:Protein Processing, Post-Translational; D016875:tau Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology
chemical_list: D020033:Protein Isoforms; D016875:tau Proteins