title: Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.
abstract: IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.
authors.affiliation: Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 94110, USA. lishomwa.ndhlovu@ucsf.edu
authors.forename: Lishomwa C
authors.initials: LC
authors.lastname: Ndhlovu
authors.forename: Joan M
authors.initials: JM
authors.lastname: Chapman
authors.forename: Aashish R
authors.initials: AR
authors.lastname: Jha
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Snyder-Cappione
authors.forename: Moraima
authors.initials: M
authors.lastname: Pagán
authors.forename: Fabio E
authors.initials: FE
authors.lastname: Leal
authors.forename: Brigid S
authors.initials: BS
authors.lastname: Boland
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Norris
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rosenberg
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Nixon
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis*; D019562:Viral Load; D014766:Viremia / Q000276:immunology / Q000821:virology
chemical_list: D020381:Interleukin-17