TORCing up metabolic control in the brain.
Transducer of regulated CREB activity 2 (TORC2) is a coactivator of CREB and an important regulator of energy balance in mammals through control of gluconeogenesis in the liver. In this issue of Cell Metabolism, Wang and coworkers (2008) report an intriguing role for Drosophila TORC in the neuronal regulation of metabolism.
Hietakangas
Ville
V
Temasek Life Sciences Laboratory, 1 Research Link, Singapore 11706. ville@tll.org.sg
Cohen
Stephen M
SM
D000818:Animals; D001921:Brain / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster; D005943:Gluconeogenesis / Q000502:physiology; D010766:Phosphorylation; D014157:Transcription Factors / Q000378:metabolism*
D017362:Cyclic AMP Response Element-Binding Protein; D029721:Drosophila Proteins; D014157:Transcription Factors