Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome.
OBJECTIVE
To report the case of a patient with a virilizing ovarian Leydig cell tumor and subclinical Cushing syndrome attributable to an adrenal adenoma.


METHODS
Detailed clinical, laboratory, radiologic, and pathologic findings are presented, and the pertinent literature is reviewed.


RESULTS
A 49-year-old woman was referred for evaluation of a left adrenal mass (3.0 by 2.4 cm), which had been diagnosed by computed tomographic scan 4 years previously during a work-up for hirsutism. On examination, she had central obesity, facial hirsutism, and male pattern baldness. Work-up showed elevated total and free testosterone levels of 196 ng/dL (reference range, 20 to 70) and 24 pg/mL (1 to 9), respectively. Other results (and reference ranges) were as follows: dehydroepiandrosterone sulfate, 7.5 microg/dL (10 to 221); corticotropin, 12 pg/mL (5 to 50); morning cortisol, 1.4 microg/dL after a 1-mg overnight dexamethasone suppression test; and urine free cortisol, 48.8 microg/24 h (20 to 100). The testosterone level decreased by 14% after a 2-day low-dose dexamethasone suppression test. Findings on transvaginal ovarian ultrasonography and a computed tomographic scan of the pelvis were normal. A laparoscopic adrenalectomy revealed an adrenal adenoma. On the first day postoperatively, the cortisol level was less than 1.0 microg/dL; however, the testosterone level remained elevated. At 6 months postoperatively, a normal result of a cosyntropin stimulation test indicated recovery of the hypothalamic-pituitary-adrenal axis. Bilateral oophorectomy revealed a 1.3-cm right ovarian Leydig cell tumor. Postoperatively, the testosterone level declined to less than 20 ng/dL.


CONCLUSIONS
To our knowledge, this is the first case report of a virilizing ovarian Leydig cell tumor in a patient with subclinical Cushing syndrome.
Diab
Dima L
DL
Department of Endocrinology, The Cleveland Clinic, OH 44195, USA.
Faiman
Charles
C
Siperstein
Allan E
AE
Grossman
William F
WF
Rabinowitz
Laura O
LO
Hamrahian
Amir H
AH
D000236:Adenoma / Q000150:complications / Q000175:diagnosis; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000175:diagnosis* / Q000209:etiology
D013739:Testosterone