title: Long-term consequences of soman poisoning in mice: part 2. Emotional behavior.
abstract: The organophosphorus compound soman produces long-lasting epileptic seizure activity which is associated to brain damage, more particularly in the hippocampus and the amygdala. The companion paper (see part 1 in the same journal issue) describes the neuropathology in the amygdala of soman-poisoned mice. The present paper examines the long-term effects of soman poisoning on emotional reactivity in mice, 30 or 90 days after intoxication using behavioral tasks involving amygdala function. The emotional behavior was estimated in animal tests of unconditioned fear (light/dark boxes, elevated plus-maze) and conditioned fear (auditory and contextual response). In the light/dark boxes and elevated plus-maze, mice intoxicated with soman (110 microg/kg, 1.2 LD(50)) showed an anxiety-like behavior profile at post-poisoning days 30 and 90. In conditioned fear, results showed that both auditory and contextual conditioned responses are increased on post-soman day 30 but no longer on post-soman day 90, evidencing behavioral recovery overtime. This latter behavioral result is in accordance with the delayed neuronal regeneration patterns described in the companion paper (part 1).
authors.affiliation: Département de physiologie intégrée, IMASSA, B.P. 73, 91223 BRETIGNY SUR ORGE cedex, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Coubard
authors.forename: Daniel
authors.initials: D
authors.lastname: Béracochéa
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Collombet
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Philippin
authors.forename: Ali
authors.initials: A
authors.lastname: Krazem
authors.forename: Pierrette
authors.initials: P
authors.lastname: Liscia
authors.forename: Guy
authors.initials: G
authors.lastname: Lallement
authors.forename: Christophe
authors.initials: C
authors.lastname: Piérard
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D003213:Conditioning, Psychological / Q000187:drug effects; D004644:Emotions / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects; D019416:Head Movements / Q000187:drug effects; D046353:Immobility Response, Tonic / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D011187:Posture / Q000502:physiology; D012999:Soman / Q000506:poisoning*; D013997:Time Factors
chemical_list: D002800:Cholinesterase Inhibitors; D012999:Soman