Does activation of the blood coagulation cascade have a role in malaria pathogenesis?
Plasmodium falciparum infection is often associated with a procoagulant state. Recent identification of tissue factor in the brain endothelium of patients who have died from cerebral malaria casts new light on our understanding of the coagulation disorder found in P. falciparum infection. It has also been revealed that parasitized red blood cells support the assembly of multimolecular coagulation complexes. Tissue factor expression by the endothelium and amplification of the coagulation cascade by parasitized red blood cells and/or activated platelets (particularly at sequestration sites) have crucial roles in mounting and sustaining a coagulation-inflammation cycle which contributes to organ dysfunction and coma in falciparum malaria.
Francischetti
Ivo M B
IM
Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ifrancischetti@niaid.nih.gov
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D016779:Malaria, Cerebral / Q000469:parasitology* / Q000473:pathology; D016778:Malaria, Falciparum / Q000469:parasitology* / Q000473:pathology; D010963:Plasmodium falciparum / Q000472:pathogenicity*; D012720:Severity of Illness Index