title: The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny.
abstract: Here, we investigated the cell killing effectiveness of heavy-ion radiation in Bcl-2 overexpressing radioresistant tumor cells. First, irradiated cells underwent primary colony formation. Radioresistance decreased with increasing linear energy transfer (LET), indicating that heavy ions may be a promising therapeutic modality for Bcl-2 overexpressing tumors. Second, cells in primary colonies were reseeded for secondary colony formation. The incidence of delayed reproductive death increased with LET irrespective of Bcl-2 overexpression, suggesting that Bcl-2 overexpression may not facilitate heavy ion-induced genomic instability.
authors.affiliation: Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Gunma 370-1292, Japan. hamada@med.gunma-u.ac.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamada
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Hara
authors.forename: Motoko
authors.initials: M
authors.lastname: Omura-Minamisawa
authors.forename: Tomoo
authors.initials: T
authors.lastname: Funayama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sakashita
authors.forename: Sakura
authors.initials: S
authors.lastname: Sora
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D016923:Cell Death; D002470:Cell Survival; D005720:Gamma Rays; D019254:Genes, bcl-2; D006367:HeLa Cells; D020450:Heavy Ions; D006801:Humans; D018499:Linear Energy Transfer; D011836:Radiation Tolerance; D011839:Radiation, Ionizing