title: Different evolutionary strategies for the origin of caspase-1 inhibitors.
abstract: Caspase 1 (CASP-1) inhibitors share sequence similarity to CASP-1 itself and are all mapped to chr11q22.3. Here we show that these inhibitors are all products of a series of gene duplications that occurred at this locus after the divergence between human and mouse. Surprisingly, stop codons originated independently in all duplicated copies to generate CARD-only proteins with inhibitory activity. We discuss this evolutionary model in the context of both neo- and subfunctionalization.
authors.affiliation: Ludwig Institute for Cancer Research, São Paulo Branch, Sao Paulo, Brazil.
authors.forename: Júlia P C
authors.initials: JP
authors.lastname: da Cunha
authors.forename: Pedro A F
authors.initials: PA
authors.lastname: Galante
authors.forename: Sandro J
authors.initials: SJ
authors.lastname: de Souza
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D020170:Caspase 1 / Q000235:genetics; D018388:Codon, Terminator; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics*; D019143:Evolution, Molecular; D005091:Exons; D020440:Gene Duplication; D020131:Genes, Duplicate; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007438:Introns; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C495731:CARD17 protein, human; C415523:CARD18 protein, human; D002352:Carrier Proteins; D018388:Codon, Terminator; D015853:Cysteine Proteinase Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; C436144:LLID-114769 protein, human; D020170:Caspase 1