Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol.
The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan. To evaluate antiallergic effect of PL, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors induced by compound 48/80. PL, paeoniflorin and paeonol potently inhibited PCA reaction and scratching behaviors in mice. Paeoniflorin exhibited the most potent inhibition against scratching behaviors and the acetic acid-induced writhing syndrome in mice. Paeonol most potently inhibited PCA reaction and mast cells degranulation. These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol.
Lee
Bomi
B
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, Korea.
Shin
Yong-Wook
YW
Bae
Eun-Ah
EA
Han
San-Jun
SJ
Kim
Joo-Sun
JS
Kang
Sam-Sik
SS
Kim
Dong-Hyun
DH
D019342:Acetic Acid; D000098:Acetophenones / Q000302:isolation & purification / Q000494:pharmacology*; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000982:Antipruritics / Q000302:isolation & purification / Q000494:pharmacology*; D001249:Asthma / Q000276:immunology / Q000517:prevention & control; D001522:Behavior, Animal / Q000187:drug effects; D001565:Benzoates / Q000302:isolation & purification / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D015550:Cell Degranulation / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D039821:Monoterpenes; D010047:Ovalbumin; D029596:Paeonia / Q000737:chemistry; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D018517:Plant Roots; D011537:Pruritus / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine; D006027:Glycosides
D019342:Acetic Acid; D000098:Acetophenones; D000700:Analgesics; D018926:Anti-Allergic Agents; D000982:Antipruritics; D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides; D039821:Monoterpenes; D010047:Ovalbumin; D003189:p-Methoxy-N-methylphenethylamine; C015423:peoniflorin; D006027:Glycosides; C013638:paeonol