title: Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study.
abstract: BACKGROUND
  The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown.
  
  
  OBJECTIVE
  To determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy.
  
  
  METHODS
  Prospective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to typical (n=45) and atypical (n=25) antipsychotics was compared with data for a reference group of infants (n=38).
  
  
  RESULTS
  Infants exposed to atypical antipsychotics had a significantly higher incidence of large for gestational age (LGA) than both comparison groups and a mean birth weight significantly heavier than those exposed to typical antipsychotics. In contrast those exposed to typical antipsychotics had a significantly lower mean birth weight and a higher incidence of small for gestational age infants than the reference group.
  
  
  CONCLUSIONS
  In utero exposure to atypical antipsychotic drugs may increase infant birth weight and risk of LGA.
authors.affiliation: University of Newcastle, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK. R.H.McAllister-Williams@ncl.ac.uk
authors.forename: James J
authors.initials: JJ
authors.lastname: Newham
authors.forename: Simon H
authors.initials: SH
authors.lastname: Thomas
authors.forename: Karine
authors.initials: K
authors.lastname: MacRitchie
authors.forename: Patricia R
authors.initials: PR
authors.lastname: McElhatton
authors.forename: R Hamish
authors.initials: RH
authors.lastname: McAllister-Williams
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects; D001724:Birth Weight / Q000187:drug effects*; D003024:Clozapine / Q000009:adverse effects; D005260:Female; D005320:Fetal Macrosomia / Q000139:chemically induced* / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D000077152:Olanzapine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000523:psychology; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D003024:Clozapine; D000077152:Olanzapine