title: [Problems and recent advances in measurement of (1-->3)-beta-D-glucan].
abstract: Measurement of (1-->3)-beta-D-glucan for invasive fungal infection is used practically in Japan. The problem of false positive results due to the frequent occurrence of non-specific reaction in alkaline treatment, chromogenic automated kinetic assay to measure (1-->3)-beta-D-glucan had been recognized in Japan. But this important problem was resolved in July 2005 by improvement made in the pretreatment reagent in a (1-->3)-beta-D-glucan measurement kit. In this manuscript, we describe the process of improvement of this kit and its clinical usefulness.
authors.affiliation: Department of Clinical Infectious Diseases, School of Medicine, Showa University.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yoshida
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shoji
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Niki
mesh_terms: D015415:Biomarkers / Q000097:blood; D019963:Clinical Chemistry Tests / Q000379:methods*; D005189:False Positive Reactions; D006801:Humans; D009181:Mycoses / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D047071:beta-Glucans / Q000097:blood*
chemical_list: D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D047071:beta-Glucans; C033363:beta-1,3-glucan