[Problems and recent advances in measurement of (1-->3)-beta-D-glucan].
Measurement of (1-->3)-beta-D-glucan for invasive fungal infection is used practically in Japan. The problem of false positive results due to the frequent occurrence of non-specific reaction in alkaline treatment, chromogenic automated kinetic assay to measure (1-->3)-beta-D-glucan had been recognized in Japan. But this important problem was resolved in July 2005 by improvement made in the pretreatment reagent in a (1-->3)-beta-D-glucan measurement kit. In this manuscript, we describe the process of improvement of this kit and its clinical usefulness.
Yoshida
Koichiro
K
Department of Clinical Infectious Diseases, School of Medicine, Showa University.
Shoji
Hisashi
H
Niki
Yoshihito
Y
D015415:Biomarkers / Q000097:blood; D019963:Clinical Chemistry Tests / Q000379:methods*; D005189:False Positive Reactions; D006801:Humans; D009181:Mycoses / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D047071:beta-Glucans / Q000097:blood*
D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D047071:beta-Glucans; C033363:beta-1,3-glucan