title: Selective thyromimetics for atherosclerosis and dyslipidaemia: another old target making progress.
abstract: BACKGROUND
  Whereas many new targets for drug discovery have been identified from new biology, such as that from the Human Genome Project, some targets have been known for decades but have not been exploited.
  
  
  OBJECTIVE
  One such target, selective thyromimetics, is reviewed from a historical perspective and in the light of recent developments.
  
  
  METHODS
  The history of thyromimetics in atherosclerosis and dyslipidaemia is reviewed as the background to the recent publication of the first human data on a new selective thyromimetic, KB-2115 (eprotirome).
  
  
  CONCLUSIONS
  The published data provide proof of concept/mechanism, opening the way to larger studies in a wider range of subjects and in combination with statins.
authors.forename: Keith
authors.initials: K
authors.lastname: Suckling
mesh_terms: D000813:Anilides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy*; D015195:Drug Design; D050171:Dyslipidemias / Q000188:drug therapy*; D006801:Humans; D015394:Molecular Structure; D013963:Thyroid Hormones / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology
chemical_list: C526273:3-((3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid; D000813:Anilides; D013963:Thyroid Hormones