title: Synthesis of novel monodentate phosphoramidites and their application in iridium-catalyzed asymmetric hydrogenations.
abstract: New monodentate H(8)-binaphthol based phosphoramidites 6 b-i have been prepared. Starting from (S)-3,3'-dibromo-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diol 3, a general protocol for the synthesis of ligands 6 is presented. A small ligand library bearing aryl substituents in the 3,3'-position of the binaphthol core was synthesized and successfully tested in the iridium-catalyzed asymmetric hydrogenation of 2-amidocinnamates to obtain different alpha-amino acid derivatives in up to 99 % ee.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
authors.forename: Giulia
authors.initials: G
authors.lastname: Erre
authors.forename: Kathrin
authors.initials: K
authors.lastname: Junge
authors.forename: Stephan
authors.initials: S
authors.lastname: Enthaler
authors.forename: Daniele
authors.initials: D
authors.lastname: Addis
authors.forename: Dirk
authors.initials: D
authors.lastname: Michalik
authors.forename: Anke
authors.initials: A
authors.lastname: Spannenberg
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller