Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione.
The novel complexes [Pd(L-L')(SR)Cl] where L-L' is Ph(2)PCH(2)CH(2)PPh(2) (dppe) or Ph(2)AsCH(2)CH(2)PPh(2) (dadpe) and RSH is glutathione, L-cysteine, or N-acetyl-L-cysteine, have been prepared and characterised. Their structures in the solid-state and in solution are discussed. The introduction of cysteine or glutathione as a ligand in these complexes greatly improved their aqueous solubility compared with the hydrophobic parent dichloro complexes. The cytotoxicities of the glutathione complexes towards the cell-lines L1210, ADJ/PC6 and CH1 were investigated. Their cytotoxicities towards L1210 cells were comparable to those of the parent dichloro complexes.
Dhubhghaill
O M
OM
Department of Chemistry Birkbeck College University of London Gordon House, 29 Gordon Square London WC1H OPP United Kingdom.
Sadler
P J
PJ
Fernandez
E G
EG