The two-component system CesRK controls the transcriptional induction of cell envelope-related genes in Listeria monocytogenes in response to cell wall-acting antibiotics.
The two-component system CesRK of Listeria monocytogenes responds to cell wall-acting antibiotics. We show here that CesRK controls the transcription of several cell envelope-related genes. The CesRK-dependent induction of these genes may be viewed as an attempt by L. monocytogenes to protect itself against the damaging effects of cell wall-acting antibiotics.
Gottschalk
Sanne
S
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Bygebjerg-Hove
Iver
I
Bonde
Mette
M
Nielsen
Pia Kiil
PK
Nguyen
Thanh Ha
TH
Gravesen
Anne
A
Kallipolitis
Birgitte H
BH
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002444:Cefuroxime / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C487493:CesR protein, Listeria monocytogenes; D014157:Transcription Factors; D000431:Ethanol; D014640:Vancomycin; D000667:Ampicillin; D011494:Protein Kinases; C487494:CesK protein, Listeria monocytogenes; D002444:Cefuroxime