title: A C-3 methylated isocembranoid and 10-oxocembranoids from a formosan soft coral, Sinularia grandilobata.
abstract: Five new cembranoids, designated grandilobatins A-E (1- 5), were isolated from the soft coral Sinularia grandilobata. Grandilobatin C (3) was found to have a novel skeleton with the C-4 methyl group of the normal cembranoid rearranged to C-3, while the other metabolites were identified as new 10-oxocembranoids. Metabolite 4 has weak cytotoxicity toward MDA-MB-23 human breast tumor cells. Also, 4 significantly inhibited the accumulation of the pro-inflammatory iNOS protein of LPS-stimulated RAW264.7 macrophage cells at 50 microM.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Tai
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Hu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003198:Computer Simulation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects; D013624:Taiwan
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II