title: The first documented case of brucellosis manifested with pancytopenia and capillary leak syndrome.
abstract: Hematological complications have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. Also, capillary leak syndrome has been rarely reported in the literature. In this report, we present a case of brucellosis with pancytopenia leading to capillary leak syndrome. A 21-year-old man was admitted to hospital with complaints of a one-month history of weakness, sweats, and fever and he had hepatosplenomegaly and edema over the pretibial areas. Hemogram revealed pancytopenia and biochemical tests revealed moderate hypoalbuminemia, elevations of lactate dehydrogenase and aspartate aminotransferase. He was diagnosed as brucellosis and capillary leak syndrome. He was given doxycycline and rifampicin. The patient's symptoms were resolved after treatment.
authors.affiliation: Department of Hematology, Gulhane Military Medical Academy, Ankara, Turkey. erkurtali@hotmail.com
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Erkurt
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Hanefi Cem
authors.initials: HC
authors.lastname: Gül
authors.forename: Omer
authors.initials: O
authors.lastname: Coskun
authors.forename: Can Polat
authors.initials: CP
authors.lastname: Eyigün
authors.forename: Cengiz
authors.initials: C
authors.lastname: Beyan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002006:Brucellosis / Q000150:complications* / Q000188:drug therapy; D019559:Capillary Leak Syndrome / Q000188:drug therapy / Q000209:etiology*; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000188:drug therapy / Q000209:etiology*; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline; D012293:Rifampin