IRAK-4 inhibitors. Part 1: a series of amides.
The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.
Buckley
George M
GM
UCB, Department of Medicinal Chemistry, Granta Park, Great Abington, Cambridge, CB21 6GS, UK.
Gowers
Lewis
L
Higueruelo
Alicia Perez
AP
Jenkins
Kerry
K
Mack
Stephen R
SR
Morgan
Trevor
T
Parry
David M
DM
Pitt
William R
WR
Rausch
Oliver
O
Richard
Marianna D
MD
Sabin
Verity
V
Fraser
Joanne L
JL
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D053592:Interleukin-1 Receptor-Associated Kinases / Q000037:antagonists & inhibitors*; D008954:Models, Biological; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000577:Amides; D004791:Enzyme Inhibitors; D011725:Pyridines; D054852:Small Molecule Libraries; D053592:Interleukin-1 Receptor-Associated Kinases