A unique family of stable and water-soluble S-nitrosothiol complexes.
In this work, we present a complete and detailed experimental characterization and theoretical study of a variety of coordinated S-nitrosothiols (RSNOs), such as cysteine derivatives, mercaptosuccinic acid, benzyl thiol, and phenyl thiol. Some of them are extremely unstable and sensitive in free form. Strikingly, in contrast with free S-nitrosothiols, we found that, upon coordination to iridium, they become very stable even in aqueous solutions. The study of these coordinated complexes provides further insight on the elucidation of structural aspects dealing with the nature of the S-N bond in RSNOs, a fact which still remains a matter of controversy.
Perissinotti
Laura L
LL
Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, (C1428EHA) Buenos Aires, Argentina.
Leitus
Gregory
G
Shimon
Linda
L
Estrin
Dario
D
Doctorovich
Fabio
F
D018360:Crystallography, X-Ray; D003545:Cysteine / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D017680:Potassium Compounds / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*; D012995:Solubility; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013870:Thiomalates / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D004952:Esters; D017680:Potassium Compounds; D026403:S-Nitrosothiols; D013870:Thiomalates; D014867:Water; C046062:2-thiomalic acid; D003545:Cysteine