Kinetic analysis of drug release from nanoparticles.
OBJECTIVE
Comparative drug release kinetics from nanoparticles was carried out using conventional and our novel models with the aim of finding a general model applicable to multi mechanistic release. Theoretical justification for the two best general models was also provided for the first time.


METHODS
Ten conventional models and three models developed in our laboratory were applied to release data of 32 drugs from 106 nanoparticle formulations collected from literature. The accuracy of the models was assessed employing mean percent error (E) of each data set, overall mean percent error (OE) and number of Es less than 10 percent.


RESULTS
Among the models the novel reciprocal powered time (RPT), Weibull (W) and log- probability (LP) ones produced OE values of 6.47, 6.39 and 6.77, respectively. The OEs of other models were higher than 10%. Also the number of errors less than 10 percent for the models was 84.9, 80.2 and 78.3 percents of total number of data sets.


CONCLUSIONS
Considering the accuracy criteria the reciprocal powered time model could be suggested as a general model for analysis of multi mechanistic drug release from nanoparticles. Also W and LP models were the closest to the suggested model.
Barzegar-Jalali
Mohammad
M
Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. mahbarja@gmail.com
Adibkia
Khosro
K
Valizadeh
Hadi
H
Shadbad
Mohammad Reza Siahi
MR
Nokhodchi
Ali
A
Omidi
Yadollah
Y
Mohammadi
Ghobad
G
Nezhadi
Somayeh Hallaj
SH
Hasan
Maryam
M
D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D007700:Kinetics; D008954:Models, Biological; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004337:Drug Carriers; D004364:Pharmaceutical Preparations