title: Substituted amylose matrices for oral drug delivery.
abstract: High amylose corn starch was used to obtain substituted amylose (SA) polymers by chemically modifying hydroxyl groups by an etherification process using 1,2-epoxypropanol. Tablets for drug-controlled release were prepared by direct compression and their release properties assessed by an in vitro dissolution test (USP XXIII no 2). The polymer swelling was characterized by measuring gravimetrically the water uptake ability of polymer tablets. SA hydrophilic matrix tablets present sequentially a burst effect, typical of hydrophilic matrices, and a near constant release, typical of reservoir systems. After the burst effect, surface pores disappear progressively by molecular association of amylose chains; this allows the creation of a polymer layer acting as a diffusion barrier and explains the peculiar behaviour of SA polymers. Several formulation parameters such as compression force, drug loading, tablet weight and insoluble diluent concentration were investigated. On the other hand, tablet thickness, scanning electron microscope analysis and mercury intrusion porosimetry showed that the high crushing strength values observed for SA tablets were due to an unusual melting process occurring during tabletting although the tablet external layer went only through densification, deformation and partial melting. In contrast, HPMC tablets did not show any traces of a melting process.
authors.affiliation: Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada.
authors.forename: S H
authors.initials: SH
authors.lastname: Moghadam
authors.forename: H W
authors.initials: HW
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Saddar El-Leithy
authors.forename: C
authors.initials: C
authors.lastname: Chebli
authors.forename: L
authors.initials: L
authors.lastname: Cartilier
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000737:chemistry*; D000284:Administration, Oral; D000688:Amylose / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D008422:Materials Testing; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D014677:Pharmaceutical Vehicles; D000082:Acetaminophen; D013213:Starch; D000688:Amylose