title: [Primary Leishmania infantum MON-80 endonasal leishmaniasis in Tunisia].
abstract: BACKGROUND
  Mucocutaneous leishmaniasis is endemic in Central and South America. It causes massive mutilating and disfiguring lesions and can lead to destruction of facial structures. In Tunisia, leishmaniasis of the mucous membranes is rare, usually developing as a complication of cutaneous leishmaniasis via direct extension. We report the first case in Tunisia of isolated and primary nasal leishmaniasis.
  
  
  METHODS
  A 70-year-old man with a history of nephrectomy for renal lithiasis was seen with a painless nodule that had been present for one month. The latter was erythematous, polypoid and firm, with a diameter of 2 cm, and was situated in the right endonasal mucosa. The diagnosis of leishmaniasis was confirmed by histological and direct examinations revealing high numbers of amastigotes of Leishmania. Culture of the offending organism in NNN medium and isoenzymatic characterization resulted in identification of MON-80 Leishmania infantum leishmaniasis. The outcome was good with treatment, and the nodule was deflated after six months.
  
  
  CONCLUSIONS
  There have been few reports of similar cases of primary and isolated mucosal leishmaniasis caused by Leishmania infantum. Our case is also unusual in that zymodeme MON-80 is only rarely a cause of Mediterranean leishmaniasis.
authors.affiliation: Service de dermatologie, hôpital Habib-Thameur, 8 rue Ali-Ben-Ayed, 1008 Montfleury, Tunis, Tunisia. rym.benmously@rns.tn
authors.forename: R
authors.initials: R
authors.lastname: Benmously-Mlika
authors.forename: S
authors.initials: S
authors.lastname: Fenniche
authors.forename: N
authors.initials: N
authors.lastname: Kerkeni
authors.forename: K
authors.initials: K
authors.lastname: Aoun
authors.forename: A
authors.initials: A
authors.lastname: Khedim
authors.forename: I
authors.initials: I
authors.lastname: Mokhtar
mesh_terms: D000368:Aged; D000818:Animals; D006801:Humans; D018314:Leishmania infantum / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000175:diagnosis*; D008297:Male; D009297:Nasal Mucosa / Q000469:parasitology; D009392:Nephrectomy; D009668:Nose Diseases / Q000469:parasitology*; D014416:Tunisia