Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A.
In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
Bringmann
Gerhard
G
Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
Gulder
Tobias A M
TA
Lang
Gerhard
G
Schmitt
Stefanie
S
Stöhr
Rüdiger
R
Wiese
Jutta
J
Nagel
Kerstin
K
Imhoff
Johannes F
JF