title: Gastric corpus polyps associated with Proton Pump Inhibitors therapy.
abstract: The prevalence of Gastroesophageal Reflux Disease (GERD) is rapidly rising in Asia. We describe here a case of 51 years old man who had surgery for esophageal leiomyoma and received long-term therapy with Proton Pump Inhibitors (PPIs) for persisting reflux symptoms. On Esophago-Gastroduodenoscopy (EGD) several sessile polyps were seen in the gastric corpus. Earlier EGD done 15 years back had not demonstrated those polyps. Sections revealed polypoid fragments of glandular epithelium with dilated glands and negative histology for H. pylori. Polymerase chain reaction for 16S ribosomal RNA gene (16S rRNA PCR) of H. pylori was also negative. This is the first report originating from an Asian country describing Fundal Gland Polyps (FGPs) in the corpus of stomach rather than fundus in a patient on long-term PPI therapy.
authors.affiliation: Department of Medicine, The Aga Khan University Hospital, Karachi. yakoobjaved@hotmail.com
authors.forename: Javed
authors.initials: J
authors.lastname: Yakoob
authors.forename: Zaigham
authors.initials: Z
authors.lastname: Abbas
authors.forename: Wasim
authors.initials: W
authors.lastname: Jafri
authors.forename: Zubair
authors.initials: Z
authors.lastname: Ahmad
mesh_terms: D004938:Esophageal Neoplasms / Q000150:complications / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000209:etiology* / Q000473:pathology; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D054328:Proton Pump Inhibitors