Lower breast cancer survival in mothers of children with a malignancy: a national study.
As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival.
Olsson
H
H
Department of Oncology, Institution of Clinical Sciences, Lund University, Lund SE-221 85, Sweden. hakan.olsson@med.lu.se
Magnusson
S
S
Bladström
A
A
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality*; D005260:Female; D016158:Genes, p53; D006801:Humans; D008875:Middle Aged; D009035:Mothers; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D011379:Prognosis