Prevalence of abnormal glucose metabolism in Chinese renal transplant recipients: a single centre study.
BACKGROUND
Post-transplant diabetes mellitus (PTDM) after renal transplantation is associated with adverse outcome on patient and graft survival. Fasting blood glucose alone will underestimate diabetes and also ignores diagnosis of impaired glucose tolerance (IGT). IGT has a strong correlation with diabetes and cardiovascular risk.


METHODS
In this cross-sectional study, we estimate the prevalence of abnormal glucose metabolism (AGM) using oral glucose tolerance test (OGTT) and identify its predictive factors. Patients who received kidney transplantation in our centre without pre-transplant diabetes were recruited. OGTT was performed in patients with fasting glucose levels between 5.6 and 6.9 mmol/L for at least two occasions 6 months post-transplantation.


RESULTS
Of 119 patients recruited, 31 had OGTT performed. The prevalence of PTDM, IGT and IFG was 21.8 (26/119)%, 6.7 (8/119)% and 3.4 (4/119)% respectively. Thus the overall prevalence of AGM was 31.9%. Age (P = 0.003), body mass index (P = 0.032), hepatitis B seropositivity status (P = 0.01), CMV infection (P = 0.02) and acute rejection (P = 0.002) were all associated with development of AGM. Using multivariate analysis, only older age at transplant (OR 1.09), history of acute rejection (OR 3.40) and hepatitis B seropositivity (OR 3.13) were significantly associated with the development of AGM.


CONCLUSIONS
AGM is common in our renal transplant recipients.
Chan
Hoi Wong
HW
enal Unit, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, China SAR.
Cheung
Chi Yuen
CY
Liu
Yan Lun
YL
Chan
Yiu Han
YH
Wong
Ho Sing
HS
Chak
Wai Leung
WL
Choi
Koon Shing
KS
Chau
Ka Foon
KF
Li
Chun Sang
CS
D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D044882:Glucose Metabolism Disorders / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors
D001786:Blood Glucose; D005947:Glucose