title: Sézary syndrome in a cat.
abstract: Sézary syndrome is an uncommon leukemic variant of cutaneous lymphoma in cats. This cat had recurrent dermatitis with erythematous, pruritic plaques. Multiple skin imprints and biopsy samples were obtained over a 6-month period, and histopathological findings were consistent initially with eosinophilic miliary dermatitis and later with erythema multiforme. One week before death, Sézary cells were identified in the peripheral blood that expressed cluster of differentiation (CD)3 and CD8 antigens. Massive infiltration of CD3+ lymphocytes was noted in the skin and multiple internal tissues by histopathological examination. This case demonstrates the difficulty in diagnosing cutaneous lymphoma early in the disease course.
authors.affiliation: Department of Diagnostic Medicine, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66506-5705, USA.
authors.forename: Casey
authors.initials: C
authors.lastname: Wood
authors.forename: Kelli
authors.initials: K
authors.lastname: Almes
authors.forename: Mary
authors.initials: M
authors.lastname: Bagladi-Swanson
authors.forename: Brad
authors.initials: B
authors.lastname: Debey
authors.forename: Gordon
authors.initials: G
authors.lastname: Andrews
authors.forename: Jerome
authors.initials: J
authors.lastname: Nietfeld
authors.forename: Melinda
authors.initials: M
authors.lastname: Wilkerson
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000473:pathology*; D002415:Cats; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D012751:Sezary Syndrome / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D013601:T-Lymphocytes / Q000473:pathology