title: Tricuspid valve thrombus: a case report associated with gonadotropin-releasing hormone analogue therapy and review of the literature.
abstract: A 35-year-old woman with a previously repaired atrial septal defect was referred for preoperative evaluation before laparoscopic surgery. The patient was asymptomatic, and a transesophageal echocardiographic examination revealed a probable thrombus attached to the tricuspid valve. The patient's history included therapy with a gonadotropin-releasing hormone analogue and deep venous thrombosis five months earlier. The tricuspid valve thrombus disappeared after anticoagulant therapy. Warfarin was initiated for prophylaxis. During the follow-up, the patient was event-free during laparoscopic surgery and pregnancy (when warfarin was switched to acetylsalicylic acid) and gave birth to a healthy term baby. Because etiological investigations revealed no reason for the tricuspid valve thrombus, it was considered to be related to the procoagulant state induced by hormonal treatment. The patient was scheduled for close follow-up.
authors.affiliation: Akdeniz University School of Medicine, Department of Cardiology, Antalya, Turkey. ibasarici@akdeniz.edu.tr
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Basarici
authors.forename: Aytul
authors.initials: A
authors.lastname: Belgi
authors.forename: Selim
authors.initials: S
authors.lastname: Yalcinkaya
mesh_terms: D000328:Adult; D017548:Echocardiography, Transesophageal; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects*; D013927:Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014261:Tricuspid Valve / Q000000981:diagnostic imaging*
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide