Association of haplotypes of interleukin-10 gene with the risk of cancer.
Polymorphisms of promotor region of IL-8, IL-10, and IL-12 genes were analyzed in cancer patients and subjects without history of cancer. The distribution of alleles of the analyzed polymorphisms in the control group coincided with that in other Caucasian populations. The incidences of three IL-10 gene polymorphisms (G-1082A, C-819T, and C-592A) significantly differed in controls and patients. Of 8 theoretically probable IL-10 gene haplotypes determined by these polymorphisms, 3 variants were revealed. Haplotype ACC was more incident in cancer patients, while ATA haplotype was rarer. The results are in line with the findings of other studies indicating the involvement of the immune system genes in the pathogenesis of cancer.
Pogoda
T V
TV
Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow. tmolbiol@newmail.ru
Marsheva
O V
OV
Kostin
P A
PA
Maksimov
V N
VN
Kulikov
I V
IV
Openko
T G
TG
Simonova
G I
GI
Voyevoda
M I
MI
Generozov
E V
EV
Govorun
V M
VM
D000483:Alleles; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D018664:Interleukin-12 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D016209:Interleukin-8; D016753:Interleukin-10; D018664:Interleukin-12