The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats.
Heterocyclic thiosemicarbazones, thioureas and their copper, nickel, and cobalt complexes were shown to be potent hypolipidemic agents in male Sprague Dawley rats at 8 mg/kg/day, orally. These agents lowered the activity of rat hepatic rate limiting enzymes for the synthesis of cholesterol and triglycerides. The effects of these agnets on cytoplasmic ATP-dependent citrate lyase, acetyl CoA synthetase and HMG-CoA reductase activities were reduced by a magnitude to explain the reduction of serum cholesterol levels afforded by the compounds. The reduction of acetyl CoA carboxylase, sn-glycerol-3-phosphate synthetase and phosphotidylate phosphohydrolase activities caused by the derivatives is of sufficient magnitude to explain the observed reduction in serum triglycerides after administration of the agents.
Hall
I H
IH
Division of Medicinal Chemistry and Natural Products School of Pharmacy University of North Carolina Chapel Hill North Carolina 27599-7360 USA.
Chen
S Y
SY
Barnes
B J
BJ
West
D X
DX