title: Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population.
abstract: Lung cancer, a complex neoplasm of lung tissue, is influenced by several environmental and genetic factors which could be changed in each individual. Aurora-A gene is related to mitotic events such as: chromosome instability, cell cycle regulation, spindle formation, and kinetechore-microtubule connections. This centrosomic serine/threonine kinase provides a strong connection between mitotic errors and carcinogenesis. The genomic alterations such as single nucleotide polymorphisms (SNPs) can exist in molecular pathways of lung cancer. Therefore, we evaluated the role of genetic polymorphisms of Aurora-A gene in the lung cancer in the Turkish population. Genotypes of five Aurora-A polymorphisms (F31I, V57I, 6328G/A, P50L, and S104L) were determined in 102 healty controls and 102 new diagnosed lung cancer cases. All samples were genotyped with DNA sequence technique. There were not any genotype variations in P50L, S104L, and 6328G/A polymorphisms. The frequencies of both genotypes F31I and V57I in lung cancer patients were not significantly different from those in controls (p > 0.05). A multivariable logistic regression analysis including patient characteristics, such as age and gender, did not change the results.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey.
authors.forename: Irem
authors.initials: I
authors.lastname: Dogan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ekmekci
authors.forename: Ahmet Selim
authors.initials: AS
authors.lastname: Yurdakul
authors.forename: Ilke Hacer
authors.initials: IH
authors.lastname: Onen
authors.forename: Can
authors.initials: C
authors.lastname: Ozturk
authors.forename: Meltem Yalinay
authors.initials: MY
authors.lastname: Cirak
authors.forename: Aysegul
authors.initials: A
authors.lastname: Acar
authors.forename: Ece
authors.initials: E
authors.lastname: Konac
mesh_terms: D064127:Aurora Kinases; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012015:Reference Standards; D014421:Turkey / Q000453:epidemiology
chemical_list: D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases