Receptor-mediated gene delivery using chemically modified chitosan.
Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, the low specificity and low transfection efficiency of chitosan need to be solved prior to clinical application. In this paper, we focused on the galactose or mannose ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo.
Kim
T H
TH
School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
Jiang
H L
HL
Nah
J W
JW
Cho
M H
MH
Akaike
T
T
Cho
C S
CS
D001672:Biocompatible Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004247:DNA / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D018390:Gene Targeting / Q000379:methods*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014162:Transfection / Q000379:methods*
D001672:Biocompatible Materials; D004337:Drug Carriers; D011956:Receptors, Cell Surface; D004247:DNA; D048271:Chitosan