Sequence recognition and self-sorting of a dipeptide by cucurbit[6]uril and cucurbit[7]uril.
Cucurbit[7]uril forms very strong complex with zwitterionic dipeptide Phe-Gly with affinity exceeding 10(7) M(-1) and effectively recognizes peptide sequence of Phe-Gly over Gly-Phe as well as Tyr-Gly over Gly-Tyr and Trp-Gly over Gly-Trp with relative affinities of 23 000, 18 000 and 2000, respectively.
Rekharsky
Mikhail V
MV
Entropy Control Project, ICORP, JST, 2-1 Yamada-oka, Suita 565-0871, Japan. mvr@chem.eng.osaka-u.ac.jp
Yamamura
Hatsuo
H
Ko
Young Ho
YH
Selvapalam
N
N
Kim
Kimoon
K
Inoue
Yoshihisa
Y
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D004151:Dipeptides; D007093:Imidazoles; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C454805:cucurbit(6)uril