title: Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors.
abstract: Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.
authors.affiliation: Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA. hjhsieh@gene.com
authors.forename: Hsin-Ju
authors.initials: HJ
authors.lastname: Hsieh
authors.forename: Christina G S
authors.initials: CG
authors.lastname: Palmer
authors.forename: Sinead
authors.initials: S
authors.lastname: Harney
authors.forename: Hsiu-Wen
authors.initials: HW
authors.lastname: Chen
authors.forename: Lara
authors.initials: L
authors.lastname: Bauman
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Brown
authors.forename: Janet S
authors.initials: JS
authors.lastname: Sinsheimer