Effects of a chitosan membrane coated with polylactic and polyglycolic acid on bone regeneration in a rat calvarial defect.
The purpose of this study was to evaluate the effects of a chitosan membrane coated with polylactic and polyglycolic acid (PLGA) on bone regeneration in a rat calvarial defect. Surgical implantation of chitosan membranes resulted in enhanced local bone formation at both 2 and 8 weeks. In conclusion, the chitosan membrane coated with PLGA had a significant potential to induce bone formation in the rat calvarial defect model. Within the selected PLGA dose range and observation intervals, there appeared to be no meaningful differences in bone formation.
Jung
Ui-Won
UW
Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l, Korea.
Song
Kun-Young
KY
Kim
Chang-Sung
CS
Lee
Yong-Keun
YK
Cho
Kyoo-Sung
KS
Kim
Chong-Kwan
CK
Choi
Seong-Ho
SH
D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D048271:Chitosan / Q000737:chemistry / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000627:therapeutic use; D019344:Lactic Acid / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D011091:Polyesters; D011100:Polyglycolic Acid / Q000737:chemistry / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000293:injuries / Q000473:pathology / Q000601:surgery; D012887:Skull Fractures / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan