title: Antipsychotic polypharmacy in the emergency treatment of highly aggressive schizophrenic prisoners - a retrospective study.
abstract: In past years, Zuclopenthixolacetate as well as Flupentixoldecanoate have each proven to be reliable and efficient in the treatment of schizophrenic psychoses. In a specially implemented psychiatric treatment unit (PTU) we administered a high-dose depot neuroleptic combination therapy initially consisting of both substances to seriously ill schizophrenic prisoners who exhibited highly aggressive behaviour (N=20). We initially used both antipsychotics at the same time as a simple regimen in order to restore the prisoners' health to enable them to return to their home prisons. A single coercive intervention was performed in 14 out of 20 prisoners which was followed by a second one in two cases according to Article 101 of the German Code of Criminal Procedure. On average, prisoners needed a treatment course of 30.4 days. Within this time PANSS global scores were reduced by approximately 40%. Side effects occurring as a consequence of neuroleptic treatment were negligible and could be dealt with.
authors.affiliation: Central State Forensic Psychiatric Hospital of Saxony-Anhalt, Uchtspringe, Germany. j.witzel@salus-lsa.de
authors.forename: Joachim G
authors.initials: JG
authors.lastname: Witzel
authors.forename: Udo
authors.initials: U
authors.lastname: Gubka
authors.forename: Heike
authors.initials: H
authors.lastname: Weisser
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bogerts
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003006:Clopenthixol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004637:Emergency Services, Psychiatric; D005475:Flupenthixol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D010865:Pilot Projects; D011329:Prisoners; D012189:Retrospective Studies; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; C060342:clopenthixol acetate ester; C007761:flupenthixol decanoate; D003006:Clopenthixol; D005475:Flupenthixol