title: François Magendie (1783-1855) and his contributions to the foundations of neuroscience and neurosurgery.
abstract: François Magendie lived during a tumultuous period in French history. Although this early medical pioneer made significant contributions to the fields of neuroanatomy, physiology, and pharmacology, little information is found in the non-French literature regarding this significant person in history. Based on this review, one could also consider this trained surgeon as an early pioneer of neurosurgery. For example, he is known to have used Galvanic current to treat various neuralgias, described a technique for extracting cerebrospinal fluid and quantitated and described its characteristics in normal and pathological specimens, and elucidated the functions of the the cranial nerves using vivisection. Additionally, he accurately described the functions of the dorsal and ventral rootlets using vivisection, and realized that the exposed meninges were susceptible to painful stimuli. Our current knowledge is based on the early contributions of scientists such as François Magendie.
authors.affiliation: Section of Pediatric Neurosurgery, Children's Hospital, University of Alabama at Birmingham, AL 35233, USA. rstubbs@uab.edu
authors.forename: R Shane
authors.initials: RS
authors.lastname: Tubbs
authors.forename: Marios
authors.initials: M
authors.lastname: Loukas
authors.forename: Mohammadali M
authors.initials: MM
authors.lastname: Shoja
authors.forename: Ghaffar
authors.initials: G
authors.lastname: Shokouhi
authors.forename: W Jerry
authors.initials: WJ
authors.lastname: Oakes
mesh_terms: D005602:France; D049671:History, 18th Century; D049672:History, 19th Century; D009488:Neurosciences / Q000266:history*; D009493:Neurosurgery / Q000266:history*