title: New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential.
abstract: Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated.THE NEW COMPLEXES ARE: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and (1)H and (13)C NMR spectra.They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines.They were also tested for possible anti-HIV activity using the HIV-I IIIB virus and C8166 cells, but they were inactive compared with AZT.
authors.affiliation: Federal University of Paraiba Department of Chemistry/CCEN Campus 1 João Pessoa PB 58059-000 Brazil.
authors.forename: M B
authors.initials: MB
authors.lastname: de Oliveira
authors.forename: J
authors.initials: J
authors.lastname: Miller
authors.forename: R E
authors.initials: RE
authors.lastname: Banks
authors.forename: L R
authors.initials: LR
authors.lastname: Kelland
authors.forename: C A
authors.initials: CA
authors.lastname: McAuliffe
authors.forename: N
authors.initials: N
authors.lastname: Mahmood
authors.forename: I J
authors.initials: IJ
authors.lastname: Rowland