title: Fine-mapping QTL for mastitis resistance on BTA9 in three Nordic red cattle breeds.
abstract: A QTL affecting clinical mastitis and/or somatic cell score (SCS) has been reported previously on chromosome 9 from studies in 16 families from the Swedish Red and White (SRB), Finnish Ayrshire (FA) and Danish Red (DR) breeds. In order to refine the QTL location, 67 markers were genotyped over the whole chromosome in the 16 original families and 18 additional half-sib families. This enabled linkage disequilibrium information to be used in the analysis. Data were analysed by an approach that combines information from linkage and linkage disequilibrium, which allowed the QTL affecting clinical mastitis to be mapped to a small interval (<1 cM) between the markers BM4208 and INRA084. This QTL showed a pleiotropic effect on SCS in the DR and SRB breeds. Haplotypes associated with variations in mastitis resistance were identified. The haplotypes were predictive in the general population and can be used in marker-assisted selection. Pleiotropic effects of the mastitis QTL were studied for three milk production traits and eight udder conformation traits. This QTL was also associated with yield traits in DR but not in FA or SRB. No QTL were found for udder conformation traits on chromosome 9.
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Research Centre Foulum, DK-8830 Tjele, Denmark. goutam.sahana@agrsci.dk
authors.forename: G
authors.initials: G
authors.lastname: Sahana
authors.forename: M S
authors.initials: MS
authors.lastname: Lund
authors.forename: L
authors.initials: L
authors.lastname: Andersson-Eklund
authors.forename: N
authors.initials: N
authors.lastname: Hastings
authors.forename: A
authors.initials: A
authors.lastname: Fernandez
authors.forename: T
authors.initials: T
authors.lastname: Iso-Touru
authors.forename: B
authors.initials: B
authors.lastname: Thomsen
authors.forename: S
authors.initials: S
authors.lastname: Viitala
authors.forename: P
authors.initials: P
authors.lastname: Sørensen
authors.forename: J L
authors.initials: JL
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Vilkki
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian; D004041:Dietary Fats / Q000378:metabolism; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D015810:Linkage Disequilibrium; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000378:metabolism; D008414:Mastitis, Bovine / Q000235:genetics*; D018895:Microsatellite Repeats; D008892:Milk / Q000378:metabolism; D008894:Milk Proteins / Q000096:biosynthesis; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: D004041:Dietary Fats; D005819:Genetic Markers; D008894:Milk Proteins