Biochemistry of Tau in Alzheimer's disease and related neurological disorders.
Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin dimers and stabilize microtubules. Tau is strongly expressed in neurons, localized in the axon and is essential for neuronal plasticity and network. From the very beginning of Tau discovery, proteomics methods have been essential to the knowledge of Tau biochemistry and biology. In this review, we have summarized the main contributions of several proteomic methods in the understanding of Tau, including expression, post-translational modifications and structure, in both physiological and pathophysiological aspects. Finally, recent advances in proteomics technology are essential to develop further therapeutic targets and early predictive and discriminative diagnostic assays for Alzheimer's disease and related disorders.
Sergeant
Nicolas
N
Inserm, U837, place de Verdun, 59045 Lille, France.
Bretteville
Alexis
A
Hamdane
Malika
M
Caillet-Boudin
Marie-Laure
ML
Grognet
Pierre
P
Bombois
Stephanie
S
Blum
David
D
Delacourte
André
A
Pasquier
Florence
F
Vanmechelen
Eugeen
E
Schraen-Maschke
Susanna
S
Buée
Luc
L
D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D020033:Protein Isoforms; D011499:Protein Processing, Post-Translational; D016875:tau Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology
D020033:Protein Isoforms; D016875:tau Proteins