Bone involvement in exogenous hypercortisolism.
Corticosteroids remain a key component in the management of many disorders. Bone loss resulting from long-term administration of these drugs is common and osteoporosis induced by corticosteroids is the most frequent cause of secondary osteoporosis in nearly 50% of individuals on chronic corticosteroid therapy suffering from an osteoporotic fracture at some point. This article reviews the epidemiology and pathogenesis of glucocorticoid-induced osteoporosis.
Sinigaglia
L
L
Department of Rheumatology, Gaetano Pini Institute, University of Milan, 20122 Milan, Italy. sinigagl@gpini.it
Mazzocchi
D
D
Varenna
M
M
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000818:Animals; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D050723:Fractures, Bone / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control
D000305:Adrenal Cortex Hormones