title: Spontaneous leiomyosarcoma arising from the ethmoid turbinate of a rat.
abstract: Spontaneous leiomyosarcoma arising from the left ethmoid turbinate was observed microscopically in an 83-week-old male F344 rat. The tumor cells showed smooth-muscle differentiation with prominent nuclear pleomorphism and a small number of mitotic figures. The tumor cells were also immunohistochemically positive for smooth-muscle actin. The tumor protruded slightly into the nasal cavity and invaded the surrounding tissues. The present article is the first case of spontaneous leiomyosarcoma in the rat nasal cavity.
authors.affiliation: Division of Pathology, Gotemba Laboratory, Bozo (Biology & Zoology), Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan. path-k@bozo.co.jp
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kasahara
authors.forename: Seiki
authors.initials: S
authors.lastname: Yamakawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Nagatani
authors.forename: Maiko
authors.initials: M
authors.lastname: Tsurukame
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Tamura
mesh_terms: D000199:Actins / Q000032:analysis; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D005004:Ethmoid Bone / Q000737:chemistry / Q000473:pathology*; D017809:Fatal Outcome; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology*; D008297:Male; D009296:Nasal Cavity / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D012888:Skull Neoplasms / Q000737:chemistry / Q000473:pathology*; D014420:Turbinates / Q000737:chemistry / Q000473:pathology*
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; C498862:Acta2 protein, rat