title: General movements in infants born from mothers with early-onset hypertensive disorders of pregnancy in relation to one year's neurodevelopmental outcome.
abstract: BACKGROUND
  Assessment of general movements (GMs) at three months is considered useful for prediction of adverse neurological outcome in high risk infants.
  
  
  OBJECTIVE
  To study the prevalence of abnormal GMs in infants born from women with early-onset hypertensive disorders of pregnancy and the association of GMs with neurodevelopmental outcome at one year.
  
  
  METHODS
  Prospective study, part of a randomised controlled trial of pre-birth management strategies.
  
  
  METHODS
  Infants born from women with early-onset hypertensive disorders of pregnancy.
  
  
  METHODS
  GMs observation and neurological examination at term and three months corrected age; at one year neurological examination and Bayley Scales of Infant Development.
  
  
  RESULTS
  From 216 women included, 175 of 178 surviving infants (mean gestational age 31.6 weeks [SD 2.3], mean birth weight 1346 grams [SD 458]), were examined at three months. At term age normal, mildly abnormal and definitely abnormal GMs were observed in 54%, 36% and 10% respectively; and at three months in 47%, 40% and 13%. Mildly or definitely abnormal GMs at three months were not associated with abnormal neurological examination at one year, however, they were associated with delayed psychomotor development at one year (p = 0.01).
  
  
  CONCLUSIONS
  In this prospective study, including small for gestational age, preterm infants about half of them did not have normal GMs at term and three months. There was no association of GMs at term nor three months with neurological outcome at one year, but there was a significant association of GMs at three months with one year psychomotor development.
authors.affiliation: Department of Rehabilitation Medicine and Physiotherapy, VU University Medical Centre, The Netherlands. pem.vanschie@vumc.nl
authors.forename: P E M
authors.initials: PE
authors.lastname: van Schie
authors.forename: A
authors.initials: A
authors.lastname: Rep
authors.forename: W
authors.initials: W
authors.lastname: Ganzevoort
authors.forename: L
authors.initials: L
authors.lastname: de Groot
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: A G
authors.initials: AG
authors.lastname: van Wassenaer
authors.forename: J I P
authors.initials: JI
authors.lastname: de Vries
mesh_terms: D000328:Adult; D002657:Child Development / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology / Q000503:physiopathology*; D007223:Infant; D018730:Infant Behavior / Q000502:physiology*; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D009068:Movement / Q000502:physiology*; D009426:Netherlands / Q000453:epidemiology; D009460:Neurologic Examination; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D013997:Time Factors