Mammalian galectins: structure, carbohydrate specificity, and functions.
Galectins are a family of beta-galactoside binding lectins, homological by a sequence of the carbohydrate-binding site. In this review literature data about structure and carbohydrate specificity of galectins are discussed. The role of galectins in the regulation of cell adhesion in immune response, inflammation, and cancer progression is considered.
Rapoport
E M
EM
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.
Kurmyshkina
O V
OV
Bovin
N V
NV
D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D037161:Galectins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D008024:Ligands; D008322:Mammals / Q000378:metabolism; D008565:Membrane Proteins / Q000502:physiology; D017434:Protein Structure, Tertiary
D002241:Carbohydrates; D037161:Galectins; D008024:Ligands; D008565:Membrane Proteins