title: Microsphere-based once-daily modified release matrix tablets for oral administration in angina pectoris.
abstract: The objective of this research was to develop microsphere-based once-daily modified release tablet formulations of diltiazem hydrochloride (DH), a potent calcium channel blocker used in angina pectoris. For this purpose, DH-loaded microspheres were prepared by the solvent evaporation technique using Eudragit RS 100. The effect of variation in the drug/polymer ratio on the physical and release characteristics of the microspheres was investigated. After the selection of the suitable microspheres, tablets were compressed using Compritol 888 ATO, Ludipress and Cellactose 80 as different direct tableting agents and excipients. As a result, modified release tablet formulations of DH-loaded microspheres were designed successfully for oral administration once rather than two or three times a day in angina pectoris.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Ankara, Tandogan, Ankara, Turkey.
authors.forename: Ceyda T
authors.initials: CT
authors.lastname: Sengel-Türk
authors.forename: Canan
authors.initials: C
authors.lastname: Hasçicek
authors.forename: Nurşin
authors.initials: N
authors.lastname: Gönül
mesh_terms: D000180:Acrylic Resins; D000284:Administration, Oral; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004110:Diltiazem / Q000008:administration & dosage*; D005079:Excipients; D005227:Fatty Acids; D006801:Humans; D008863:Microspheres; D013607:Tablets / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D005079:Excipients; D005227:Fatty Acids; D013607:Tablets; C086409:glyceryl behenate; C050528:Eudragit RS; D004110:Diltiazem