title: Lysophosphatidic acid and renal fibrosis.
abstract: The development of fibrosis involves a multitude of events and molecules. Until now the majority of these molecules were found to be proteins or peptides. But recent data show significant involvement of the phospholipid lysophosphatidic acid (LPA) in the development of pulmonary, liver and renal fibrosis. The latest data on the role of LPA and the G-protein-coupled LPA1 receptor in the development of renal fibrosis will be discussed. LPA1-receptor activation was found to be associated with increased vascular leakage and increased fibroblast recruitment in pulmonary fibrosis. Furthermore, in renal fibrosis LPA1-receptor activation stimulates macrophage recruitment and connective tissue growth factor expression. The observations make this receptor an interesting alternative and new therapeutic target in fibrotic diseases.
authors.affiliation: Inserm, U858/I2MR, Department of Metabolism and Obesity, Team #3, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Pradère
authors.forename: Julien
authors.initials: J
authors.lastname: Gonzalez
authors.forename: Julie
authors.initials: J
authors.lastname: Klein
authors.forename: Philippe
authors.initials: P
authors.lastname: Valet
authors.forename: Sandra
authors.initials: S
authors.lastname: Grès
authors.forename: David
authors.initials: D
authors.lastname: Salant
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Bascands
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Saulnier-Blache
authors.forename: Joost P
authors.initials: JP
authors.lastname: Schanstra
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000503:physiopathology; D008246:Lysophospholipids / Q000378:metabolism*; D008954:Models, Biological; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D049368:Receptors, Lysophosphatidic Acid; C032881:lysophosphatidic acid