Hexadecameric self-assembled dendrimers built from 2'-deoxyguanosine derivatives.
Herein we describe the construction of hexadecameric self-assembled dendrimers (SADs) using a series of dendronized 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) subunits. The azido-substituted mAG subunits were covalently linked to alkynyl polyester dendrons using a copper-catalyzed 1,3-dipolar cycloaddition reaction. Discrete SADs are formed with high fidelity and thermal stability even with the increased steric hindrance offered by the dendrons.
Betancourt
José E
JE
Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.
Rivera
José M
JM
D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D013696:Temperature
D050091:Dendrimers; D003849:Deoxyguanosine