Anti-inflammatory effect of Pinus sibirica oil extract in animal models.
The anti-inflammatory effect of the oil extract of seeds of Pinus sibirica Du Tour was evaluated and compared with phenylbutazone. Oral administration of this extract at a dose of 300 mg/kg showed anti-inflammatory activity in the carrageenin-induced edema test in rats. In addition, P. sibirica oil extract showed analgesic properties in the hot-plate test and antipyretic properties in adjuvant-induced local hyperthermia, both in rats. In conclusion, these results provide evidence for the potential usefulness of P. sibirica oil extract, a defined mixture of long-chain polyunsaturated fatty acids, sterols, tocopherols and polyphenols, in inflammatory disorders.
Shikov
Alexander N
AN
Interregional Center Adaptogen, 47/5, Piskarevsky pr., St-Petersburg, 195067, Russia. adaptogen@mail.ru
Pozharitskaya
Olga N
ON
Makarov
Valery G
VG
Makarova
Marina N
MN
D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D028223:Pinus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D010938:Plant Oils; D002351:Carrageenan