title: HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy.
abstract: We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P = .01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.
authors.affiliation: Division of Infectious Diseases, University Hospital Bern and University of Bern, Switzerland. andri.rauch@insel.ch
authors.forename: Andri
authors.initials: A
authors.lastname: Rauch
authors.forename: David
authors.initials: D
authors.lastname: Nolan
authors.forename: Hansjakob
authors.initials: H
authors.lastname: Furrer
authors.forename: Elizabeth
authors.initials: E
authors.lastname: McKinnon
authors.forename: Mina
authors.initials: M
authors.lastname: John
authors.forename: Simon
authors.initials: S
authors.lastname: Mallal
authors.forename: Silvana
authors.initials: S
authors.lastname: Gaudieri
authors.forename: Huldrych F
authors.initials: HF
authors.lastname: Günthard
authors.forename: Patrick
authors.initials: P
authors.lastname: Schmid
authors.forename: Manuel
authors.initials: M
authors.lastname: Battegay
authors.forename: Bernard
authors.initials: B
authors.lastname: Hirschel
authors.forename: Amalio
authors.initials: A
authors.lastname: Telenti
authors.forename: Ian
authors.initials: I
authors.lastname: James
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015235:HLA-B Antigens; C042388:HLA-Bw4 antigen; C038652:HLA-Bw6 antigen