A novel five-way chromosomal translocation observed in chronic myelogenous leukemia.
Most patients with chronic myelogenous leukemia (CML) show a Philadelphia (Ph) chromosome with a characteristic translocation between chromosomes 9 and 22. However, there are variant complex translocations involving other chromosomes in addition to the standard translocation. We describe a case of CML showing a complex and novel chromosomal translocation involving five chromosomes, t(4;12;7;9;22).
Ikuta
Katsuya
K
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, Japan 078-8510. ikuta@asahikawa-med.ac.jp
Torimoto
Yoshihiro
Y
Jimbo
Junko
J
Inamura
Junki
J
Hosoki
Takaaki
T
Shindo
Motohiro
M
Sato
Kazuya
K
Takahashi
Hiroyuki
H
Kohgo
Yutaka
Y
D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002894:Chromosomes, Human, Pair 4; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008954:Models, Biological; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic