title: [Insulin therapy at the hospital setting].
abstract: Hyperglycemia is defined in different studies as a poor prognostic factor relating with higher risk for post-surgical infections, neurological complications, increased hospital staying, and admission to intensive care units. Appropriate use of insulin therapy is one of the key factors assuring the best management of hospitalized patients. The aim of this review was to discuss the most important aspects of insulin use at the hospital setting. We analyzed the different types of insulin commercially available and the factors determining their efficacy, as well as the different regimens and administration routes available at the hospital according to the type of patient and the type of feeding or exogenous intake of carbohydrates. The fear of inducing hypoglycemic episodes at the hospital contributes to an inappropriate prescription of the programmed insulin doses, the use of flexible rapid insulin doses in monotherapy, and setting excessively high glycemia levels. Currently, individualized management of hospital hyperglycemias should replace obsolete insulin regimens in order to reach more stringent glycemia goals and decreasing the number of complications in the hospitalized patient.
authors.affiliation: Servicio de Farmacia, Hospital Universitario 12 de Octubre, Madrid, Spain. javiersaezfuente@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Sáez de la Fuente
authors.forename: V
authors.initials: V
authors.lastname: Granja Berná
authors.forename: M A
authors.initials: MA
authors.lastname: Valero Zanuy
authors.forename: J M
authors.initials: JM
authors.lastname: Ferrari Piquero
authors.forename: A
authors.initials: A
authors.lastname: Herreros de Tejada y López Coterilla
mesh_terms: D006761:Hospitals; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007328:Insulin