Different evolutionary strategies for the origin of caspase-1 inhibitors.
Caspase 1 (CASP-1) inhibitors share sequence similarity to CASP-1 itself and are all mapped to chr11q22.3. Here we show that these inhibitors are all products of a series of gene duplications that occurred at this locus after the divergence between human and mouse. Surprisingly, stop codons originated independently in all duplicated copies to generate CARD-only proteins with inhibitory activity. We discuss this evolutionary model in the context of both neo- and subfunctionalization.
da Cunha
Júlia P C
JP
Ludwig Institute for Cancer Research, São Paulo Branch, Sao Paulo, Brazil.
Galante
Pedro A F
PA
de Souza
Sandro J
SJ
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D020170:Caspase 1 / Q000235:genetics; D018388:Codon, Terminator; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics*; D019143:Evolution, Molecular; D005091:Exons; D020440:Gene Duplication; D020131:Genes, Duplicate; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007438:Introns; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; C495731:CARD17 protein, human; C415523:CARD18 protein, human; D002352:Carrier Proteins; D018388:Codon, Terminator; D015853:Cysteine Proteinase Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; C436144:LLID-114769 protein, human; D020170:Caspase 1