A clinical electrophysiological study of emotional lability in patients with systemic lupus erythematosus.
Neuropsychiatric symptoms are well recognized in systemic lupus erythematosus (SLE), with depression and anxiety often reported. The authors' clinical observations suggested emotional lability might also be a noteworthy symptom. In a consecutive series of systemic lupus erythematosus clinic attendees the authors therefore measured depression, anxiety, and emotional lability. Additionally, based on reports linking emotional reactivity and transient mood changes to alterations in early attentional processes, the authors investigated event-related potential indices of preattentive and early orienting responses to auditory stimuli (N1, MMN, P3a and P3b). The authors observed that 15 of 32 participants with systemic lupus erythematosus had high lability scores and, comparing event-related potential measures between the high and low lability subgroups, noted that those with greater emotional lability demonstrated reduced response latencies in N1 and MMN paradigms.
Langosch
Jens
J
Department of Psychiatry at the University of Freiburg, Freiburg, Germany.
Rand
Stacey
S
Ghosh
Boyd
B
Sharma
Simeran
S
Tench
Colin
C
Stratton
Richard
R
D'Cruz
David
D
Trimble
Michael
M
Barrett
Geoff
G
Ring
Howard
H
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000342:Affective Symptoms / Q000209:etiology*; D000704:Analysis of Variance; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004644:Emotions / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011930:Reaction Time