Evaluation of SLS: APG mixed surfactant systems as carrier for solid dispersion.
The present investigation aims at studying the effect of mixed surfactant system of sodium lauryl sulphate (SLS) and alkyl polyglucosides (C(10)APG, C(12)APG and C(12/14)APG) on dissolution rate enhancement of poorly water soluble drug. Aceclofenac--a non-steroidal anti-inflammatory agent was used as a model drug as it has limited water solubility. The influence of the surfactant concentration in various blends on dissolution rate of Solid Dispersion (SD), prepared using solution method with ethanol as the solvent was studied and the advantage of mixed surfactant systems over the individual surfactants was illustrated by differences in the in-vitro dissolution profiles of SD. Physico chemical evaluation (critical micellar concentration, zeta potential and beta-parameter calculations) was carried out to study the mixed surfactant systems. Solid mixtures were characterized by Infrared spectroscopy (FT-IR); X-ray diffraction studies (XRD) and scanning electron microscopy (SEM). It was seen that the dissolution rate of aceclofenac from SD increased with the increase in the APG proportion relative to SLS with the optimum ratio of 0.2 SLS:0.8 APG showing the best effect in all cases. Results obtained from physico-chemical evaluation (the decrease in the value of critical micelle concentration and higher negative value of beta-parameters) suggested the existence of synergism between surfactants blends. The observed results in the dissolution rate enhancement could be attributed to the drug--surfactant interactions as evident from FT-IR, SEM and XRD results.
Patel
Ashok R
AR
Department of Pharmaceutical Sciences, University Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Joshi
Vishal Y
VY
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000737:chemistry; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding; D000431:Ethanol / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry*; D007700:Kinetics; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004304:Dosage Forms; D004337:Drug Carriers; D005960:Glucosides; D008823:Micelles; D012997:Solvents; D013501:Surface-Active Agents; D004008:Diclofenac; D012967:Sodium Dodecyl Sulfate; D000431:Ethanol; C056498:aceclofenac