Optical measurement of neural activity using surface plasmon resonance.
We demonstrate that surface plasmon resonance (SPR) is applicable to the optical detection of neural signals. A low-noise SPR sensor was developed as a label- and artifact-free method for the extracellular recording of neural activity. The optical responses obtained from a rat sciatic nerve were highly correlated with simultaneously recorded electrical responses. Additional studies with stimulation intensity and lidocaine further confirmed that the optically measured signals originated from neural activities.
Ae Kim
Shin
S
School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea, 151-742.
Min Byun
Kyung
K
Lee
Jonghwan
J
Hoon Kim
Jung
J
Albert Kim
Dong-Ghi
DG
Baac
Hyoungwon
H
Shuler
Michael L
ML
June Kim
Sung
S
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004594:Electrophysiology; D008012:Lidocaine / Q000494:pharmacology; D055095:Optics and Photonics; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*; D020349:Surface Plasmon Resonance / Q000379:methods
D008012:Lidocaine