title: Animal models of primary biliary cirrhosis.
abstract: Primary biliary cirrhosis (PBC) is well known as a disease that predominantly affects women and has been hitherto only described in humans. The absence of an animal model has significantly impaired research into both etiology and treatment. However, in the past 2 years, several spontaneous and two induced models of PBC were described. This article reviews the data on these animal models and places it in the perspective of human PBC and generic autoimmunity.
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Chang-Te Street, Taipei, Taiwan.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Chuang
authors.forename: William M
authors.initials: WM
authors.lastname: Ridgway
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: M Eric
authors.initials: ME
authors.lastname: Gershwin
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology / Q000473:pathology; D051379:Mice; D016688:Mice, Inbred NOD; D015375:Receptors, Interleukin-2; D018125:Receptors, Transforming Growth Factor beta
chemical_list: D015375:Receptors, Interleukin-2; D018125:Receptors, Transforming Growth Factor beta