Peptidoglycan recognition proteins-maintaining immune homeostasis and normal development.
Peptidoglycan recognition proteins (PGRPs) are innate immune molecules with a diverse array of functions. In this issue of Cell Host & Microbe, Maillet and colleagues demonstrate that a Drosophila PGRP, PGRP-LF, functions as a negative regulator of the Drosophila immune deficiency (IMD) pathway, an innate immune signaling mechanism responsive to Gram-negative bacteria. PGRP-LF deficiency results in unregulated immune signaling, causing excessive antimicrobial peptide synthesis and, surprisingly, developmental defects.
Gupta
Dipika
D
Indiana University School of Medicine Northwest, Gary, IN 46408, USA.
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D004330:Drosophila / Q000254:growth & development / Q000276:immunology* / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000276:immunology; D007113:Immunity, Innate; D010457:Peptidoglycan / Q000378:metabolism; D015398:Signal Transduction
D002352:Carrier Proteins; D010457:Peptidoglycan; C118897:peptidoglycan recognition protein