Response of Sinorhizobium meliloti to elevated concentrations of cadmium and zinc.
Whole-genome transcriptional profiling was used to identify genes in Sinorhizobium meliloti 1021 that are differentially expressed during exposure to elevated concentrations of cadmium and zinc. Mutant strains with insertions in metal-regulated genes and in genes encoding putative metal efflux pumps were analyzed for their metal sensitivities, revealing a crucial role for the SMc04128-encoded P-type ATPase in the defense of S. meliloti against cadmium and zinc stress.
Rossbach
Silvia
S
Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008-5410, USA. Silvia.Rossbach@wmich.edu
Mai
Danielle J
DJ
Carter
Eric L
EL
Sauviac
Laurent
L
Capela
Delphine
D
Bruand
Claude
C
de Bruijn
Frans J
FJ
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002104:Cadmium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D018869:Heat-Shock Response; D009154:Mutation; D016962:Sinorhizobium meliloti / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D001426:Bacterial Proteins; D002104:Cadmium; D015032:Zinc