Manipulating midbrain stem cell self-renewal.
In this issue of Cell Stem Cell, Falk and colleagues (Falk et al., 2008) demonstrate that differential responsiveness to TGF-beta signaling selectively modulates self-renewal of dorsal midbrain stem cells. This observation may lead to strategies for expanding specific neural stem cell subtypes.
LoTurco
Joseph J
JJ
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269-3156, USA.
Kriegstein
Arnold R
AR
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009928:Organ Specificity; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D003336:Tectum Mesencephali / Q000166:cytology* / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology*; D051155:Wnt1 Protein / Q000502:physiology
D018797:Cell Cycle Proteins; D016212:Transforming Growth Factor beta; D051155:Wnt1 Protein