title: [Case of ulcerative colitis refractory to intravenous cyclosporine therapy successfully treated with infliximab].
abstract: A 26-year-old woman was admitted to our hospital with relapse of ulcerative colitis (UC). We diagnosed it as a refractory UC because intravenous corticosteroid therapy had no effect. Intravenous cyclosporine therapy and other conventional therapies did not lead to remission. Then the possibility of infliximab was discussed with the patient and her parents and treatment with infliximab was started. Infliximab was infused intravenously at a dose of 5mg per kilograms of body weight. Immediately after the first infusion, clinical symptoms improved, and clinical remission was achieved within 12 weeks. It is suggested that infliximab can be effective for refractory UC.
authors.affiliation: Division of Gastroenterology, Sapporo Kosei General Hospital.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsuya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Motoya
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Suguru
authors.initials: S
authors.lastname: Nakagaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishioka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hagiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kozawa
authors.forename: Sei
authors.initials: S
authors.lastname: Kurokawa
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ambo
authors.forename: Akimichi
authors.initials: A
authors.lastname: Imamura
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D016572:Cyclosporine; D011239:Prednisolone; D000069285:Infliximab