Nanoparticle assisted magnetic resonance imaging of the early reversible stages of amyloid beta self-assembly.
Co@Pt-Au nanoparticles, which have enhanced magnetism and high stability in aqueous media, are utilized in conjunction with MRI to monitor the structural evolution of Abeta assemblies, especially Abeta protofibrils in the early reversible stages.
Choi
Jin-Sil
JS
Department of Chemistry, Yonsei University, Seoul, 120-749, Korea.
Choi
Hyuck Jae
HJ
Jung
Dae Chul
DC
Lee
Joo-Hyuk
JH
Cheon
Jinwoo
J
D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D003035:Cobalt / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D003035:Cobalt; D010984:Platinum