CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load.
We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.
Andrade
Adriana
A
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Bailey
Justin R
JR
Xu
Jie
J
Philp
Frances H
FH
Quinn
Thomas C
TC
Williams
Thomas M
TM
Ray
Stuart C
SC
Thomas
David L
DL
Blankson
Joel N
JN
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D008212:Lymphocyte Depletion; D008297:Male; D019562:Viral Load
D015235:HLA-B Antigens; C500126:HLA-B*58:01 antigen; C103707:HLA-B57 antigen