Nephrotoxicity in the setting of invasive fungal diseases.
Amphotericin B, a broad spectrum antifungal agent, is widely used despite significant adverse events including nephrotoxicity. Nephrotoxicity occurs frequently in patients receiving amphotericin B. Different definitions for nephrotoxicity are reviewed in the context of outcome in patients with invasive fungal diseases. In most publications, mortality was higher in patients experiencing nephrotoxicity and mean hospital length of stay was prolonged. As a consequence, the use of less nephrotoxic antifungal agents could improve treatment outcomes.
Ullmann
Andrew J
AJ
Klinikum der Johannes-Gutenberg-Universität, Mainz, Germany. ullmann@uni-mainz.de
D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D007674:Kidney Diseases / Q000139:chemically induced*; D007902:Length of Stay; D009181:Mycoses / Q000188:drug therapy* / Q000517:prevention & control; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B