Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Friesen
Richard W
RW
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada. rick_friesen@merck.com
Mancini
Joseph A
JA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D050197:Atherosclerosis / Q000201:enzymology; D005334:Fever / Q000201:enzymology; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008861:Microsomes / Q000201:enzymology*; D010146:Pain / Q000201:enzymology; D000071876:Prostaglandin-E Synthases; D020521:Stroke / Q000201:enzymology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019746:Intramolecular Oxidoreductases; C000605862:PTGES protein, human; D000071876:Prostaglandin-E Synthases; C000605865:Ptges protein, mouse