Surgical outcomes for pulmonary metastases from hepatocellular carcinoma.
BACKGROUND
Although favourable prognosis following aggressive treatment of extrahepatic metastases from hepatocellular carcinoma (HCC) has been reported, surgical outcomes for pulmonary metastases are unclear.


METHODS
Sixty-one patients (2.6%) of 2297 registered with the Metastatic Lung Tumor Study Group of Japan between 1990 and 2006, who underwent surgery for pulmonary metastases from HCC, were retrospectively reviewed from the registry.


RESULTS
The overall 5-year survival rate was 32.2%. The prognosis was significantly better for < or =2 lesions than for > or =3 lesions (p=0.046), for < or =3 lesions than for > or =4 lesions (p=0.0070), and for < or =4 lesions than for > or =5 lesions (p=0.029). No other factors that influence outcomes were identified. A stepwise regression analysis showed three or less pulmonary metastases to be an independent factor for better prognosis (p=0.048).


CONCLUSIONS
With careful patient selection, comparatively good outcomes can be expected following surgical resection of pulmonary HCC metastases. Among them, patients with multiple metastases, if number of metastases is small such as four or less, can be expected to survive long after surgery.
Kawamura
Masafumi
M
Division of General Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan. kawamura@sc.itc.keio.ac.jp <kawamura@sc.itc.keio.ac.jp>
Nakajima
Jun
J
Matsuguma
Haruhisa
H
Horio
Hirotoshi
H
Miyoshi
Shinichiro
S
Nakagawa
Ken
K
Fujisawa
Takehiko
T
Kobayashi
Koichi
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome