title: Response of Sinorhizobium meliloti to elevated concentrations of cadmium and zinc.
abstract: Whole-genome transcriptional profiling was used to identify genes in Sinorhizobium meliloti 1021 that are differentially expressed during exposure to elevated concentrations of cadmium and zinc. Mutant strains with insertions in metal-regulated genes and in genes encoding putative metal efflux pumps were analyzed for their metal sensitivities, revealing a crucial role for the SMc04128-encoded P-type ATPase in the defense of S. meliloti against cadmium and zinc stress.
authors.affiliation: Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008-5410, USA. Silvia.Rossbach@wmich.edu
authors.forename: Silvia
authors.initials: S
authors.lastname: Rossbach
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Mai
authors.forename: Eric L
authors.initials: EL
authors.lastname: Carter
authors.forename: Laurent
authors.initials: L
authors.lastname: Sauviac
authors.forename: Delphine
authors.initials: D
authors.lastname: Capela
authors.forename: Claude
authors.initials: C
authors.lastname: Bruand
authors.forename: Frans J
authors.initials: FJ
authors.lastname: de Bruijn
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002104:Cadmium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D018869:Heat-Shock Response; D009154:Mutation; D016962:Sinorhizobium meliloti / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
chemical_list: D001426:Bacterial Proteins; D002104:Cadmium; D015032:Zinc