Predictive value of individualized tumor response testing by ATP-based chemotherapy response assay in ovarian cancer.
The aim of this study is to investigate the correlation between ATP-based chemotherapy response assay (ATP-CRA) results and clinical outcomes in ovarian cancer. Twenty-nine fresh tumor specimens were collected. Tumor cells were isolated and cultured for 48 hrs in medium containing anticancer drugs. The median age of patients was 56 years. The sensitivity, positive predictive value, and accuracy of ATP-CRA were respectively 94.1%, 94.1%, and 90.0%. There was a significant relationship between ATP-CRA results and clinical responses (p = 0.046). This study suggests that ATP-CRA has high sensitivity, positive predictive value, and accuracy for predicting response to chemotherapy in ovarian cancer.
Han
Seung-Su
SS
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Choi
Sung Ho
SH
Lee
Yoo-Kyung
YK
Kim
Jae Weon
JW
Park
Noh-Hyun
NH
Song
Yong-Sang
YS
Lee
Hyo-Pyo
HP
Kang
Soon-Beom
SB
D000255:Adenosine Triphosphate / Q000032:analysis*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage / Q000494:pharmacology; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017239:Paclitaxel / Q000008:administration & dosage / Q000494:pharmacology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D000093542:Gemcitabine
D003841:Deoxycytidine; D000255:Adenosine Triphosphate; D016190:Carboplatin; D017239:Paclitaxel; D000093542:Gemcitabine