[The relationship of gastrin, pepsinogen, and Helicobacter pylori in erosive reflux esophagitis].
OBJECTIVE
Helicobacter pylori (H. pylori) infection is known as a major cause of atrophic gastritis and is associated with serum gastrin, pepsinogen, and gastric acid secretion. There is still a controversial association between gastroesophageal reflux disease and H. pylori infection. This study was designed to investigate the relationship among serum gastrin, pepsinogen, and H. pylori infection in the erosive reflux esophagitis (ERD) patients.


METHODS
Patients who were diagnosed as ERD by one gastroenterologist at the Kangnam St. Mary's hospital were prospectively enrolled. The persons without ERD in the control group were matched for age and sex. We examined the gastrin, pepsinogen I (PG I), PG II, PG I/II ratio, and H. pylori infection.


RESULTS
Forty five patients were enrolled in ERD group and 66 persons in control group. The H. pylori infection rate in ERD group was lower than that in the control group (11.1% vs. 43.9%, p<0.001). PG I/II ratio in ERD group was higher than that in the control group (7.0+/-3.1 vs. 5.3+/-2.6, p=0.003). The PG II (p=0.016) and gastrin (p=0.029) in ERD group were lower than those in the control group. BMI in ERD group was higher than that in the control group (24.5 vs. 23.1 kg/m2, p=0.013).


CONCLUSIONS
The H. pylori infection rate in ERD group was lower and PG I/II ratio was higher than that in the control group. Reflux esophagitis is thought to be reversely associated with the atrophy of gastric mucosa.
Kwon
Jung Hyun
JH
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Chung
In-Sik
IS
Son
Hye Suk
HS
Park
Jae Myung
JM
Cho
Yu Kyung
YK
Lee
In Seok
IS
Kim
Sang Woo
SW
Choi
Myung Gyu
MG
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000382:microbiology*; D005260:Female; D005755:Gastrins / Q000097:blood*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*
D005755:Gastrins; D010435:Pepsinogens