title: 5-HT2A receptor gene polymorphism and negative symptoms in first episode (drug-naive) Chinese Han nationality individuals with schizophrenia.
abstract: OBJECTIVE
  To investigate whether the 5-hydroxytryptamine 2A receptor (5-HT2A) gene T102C polymorphism is associated with the severity symptoms and negative symptoms in the first episode Chinese Han nationality patients with schizophrenia.
  
  
  METHODS
  Altogether 201 first episode Chinese Han nationality patients with schizophrenia were enrolled in this study. Genotyping of 5-HT2A gene T102C polymorphism was performed by PCR-RFLP technique. The positive and negative Symptom Scale (PANSS) was used for the evaluation of the severity of psychotic symptoms before any drug treatment.
  
  
  RESULTS
  5-HT2A receptor 102-T/T genotype was significantly associated with both the PANSS total and negative symptom subscale baseline scores before the treatment, but not with the positive and general psychopathology subscales.
  
  
  CONCLUSIONS
  5-HT2A T102C functional polymorphism may play a role in negative symptoms and prognosis of Chinese Han nationality people with schizophrenia.
authors.affiliation: Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Wen-qiang
authors.initials: WQ
authors.lastname: Li
authors.forename: Zhao
authors.initials: Z
authors.lastname: Huang
authors.forename: Yu-zhong
authors.initials: YZ
authors.lastname: Shi
authors.forename: Xu-Yi
authors.initials: XY
authors.lastname: Wang
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Huang
authors.forename: Xu-hui
authors.initials: XH
authors.lastname: Zhou
authors.forename: Hong-xian
authors.initials: HX
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Hao
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A