title: Comparison of the bony remodelling of two synthetic biomaterials: aragonite 55% and aragonite 55% with active substance.
abstract: In this work, the in vivo behaviour of pure aragonite and vectabone, which is an association of aragonite and an active substance such as gentamicin, was studied to highlight the kinetic resorption of these two biomaterials with 55% of porosity destined for the filling or replacement of bony defects. The synthesis conditions and parameters we used permit us to obtain a biomaterial without a sintering stage. These conditions allow introducing of active substances at the first stage of the elaboration. In this work, the gentamycin antibiotic was associated with calcium carbonate (aragonite 55% with gentamycin) to deliver this active substance on the surgical site for local treatment. The tricalcium phosphate biomaterial was used as the control because of its high biocompatibility. The bony remodelling of these three biomaterials was studied by in vivo experiments. This study was ensured with neutron activation analysis (NAA). The resorption kinetic was elaborated and comparisons of the remodelling biomaterials CaCO(3) 55% and CaCO(3) 55% with gentamicin (vectabone) and tricalcium phosphate were carried out. The obtained results show that, 6 months after implantation, the mineral composition of vectabone and tricalcium phosphate becomes close to that of young bone. Twelve months after implantation, it becomes similar to that of mature bone.
authors.affiliation: Université de Rennes1, UMR-CNRS 6226, campus de beaulieu, 263 av. Général Leclerc, 35042 Rennes, France. hassane.oudadesse@univ-rennes1.fr
authors.forename: H
authors.initials: H
authors.lastname: Oudadesse
authors.forename: A C
authors.initials: AC
authors.lastname: Derrien
authors.forename: S
authors.initials: S
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Lucas-Girot
authors.forename: G
authors.initials: G
authors.lastname: Cathelineau
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016723:Bone Remodeling / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry*; D002119:Calcium Carbonate / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004838:Epiphyses / Q000166:cytology / Q000254:growth & development*; D005839:Gentamicins / Q000008:administration & dosage*; D008422:Materials Testing; D012756:Sheep
chemical_list: D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D004337:Drug Carriers; D005839:Gentamicins; D002119:Calcium Carbonate