title: Continuous intra-arterial nimodipine for the treatment of cerebral vasospasm.
abstract: Two patients with refractory symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) were treated by continuous intra-arterial nimodipine infusion via a catheter placed in the internal carotid artery or vertebral artery for 3 and 12 days, respectively. Recovery of the neurological deficits, normalization of MR perfusion, a decrease in the elevated mean flow velocity measured by transcranial duplex sonography, and angiographic recanalization were observed. Continuous intra-arterial nimodipine might be a treatment option in severe refractory vasospasm following SAH.
authors.affiliation: Department of Neuroradiology, University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, Jena 07747, Germany. t.e.mayer@med.uni-jena.de
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Mayer
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
authors.forename: Andreas
authors.initials: A
authors.lastname: Straube
authors.forename: Tobias
authors.initials: T
authors.lastname: Birnbaum
authors.forename: Stephanie
authors.initials: S
authors.lastname: Müller-Schunk
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Hamann
authors.forename: Gernot
authors.initials: G
authors.lastname: Schulte-Altedorneburg
mesh_terms: D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D014665:Vasodilator Agents; D009553:Nimodipine