title: Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A.
abstract: In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
authors.affiliation: Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
authors.forename: Tobias A M
authors.initials: TA
authors.lastname: Gulder
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schmitt
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Stöhr
authors.forename: Jutta
authors.initials: J
authors.lastname: Wiese
authors.forename: Kerstin
authors.initials: K
authors.lastname: Nagel
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff