title: The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted.
abstract: The proposed use of a more precise standard for glycated (A(1c)) and non-glycated haemoglobin would lead to an A(1c) value, when expressed as a percentage, that is lower than that currently in use. One approach advocated to address the potential confusion that would ensue is to replace 'HbA(1c)' with a new term, 'A(1c)-derived average glucose.' We review evidence from several sources suggesting that A(1c) is, in fact, inherently imprecise as a measure of average glucose, so that the proposed terminology should not be adopted.
authors.affiliation: Mount Sinai School of Medicine, New York, NY 10028, USA. zbloomgard@aol.com
authors.forename: Z T
authors.initials: ZT
authors.lastname: Bloomgarden
authors.forename: S E
authors.initials: SE
authors.lastname: Inzucchi
authors.forename: E
authors.initials: E
authors.lastname: Karnieli
authors.forename: D
authors.initials: D
authors.lastname: Le Roith
mesh_terms: D001786:Blood Glucose; D002624:Chemistry, Clinical / Q000592:standards*; D003920:Diabetes Mellitus / Q000175:diagnosis*; D006442:Glycated Hemoglobin; D006801:Humans; D015203:Reproducibility of Results; D009626:Terminology as Topic
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin