HspB5/alphaB-crystallin: properties and current progress in neuropathy.
HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell structure and plays an important role in cytoprotection. Recent studies reveal that HspB5 has a strong relationship with neurological diseases acting as a protective molecular chaperone or in certain conditions, a pathogenic factor. This review gives a brief introduction on properties of HspB5, its current progress in neurological diseases and potential therapeutic intervention in demyelinating disease, neurodegenerative disease, myopathy and cerebrovascular disease.
Hu
Zhiping
Z
Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha 410011, The People's Republic of China.
Li
Ting
T
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D038203:alpha-Crystallin B Chain / Q000737:chemistry / Q000378:metabolism
D038203:alpha-Crystallin B Chain