title: Synthesis of two peptide mimetics as markers for chemical changes of wool's keratin during skin unhairing process.
abstract: The sheep skins unhairing process with preliminary alkaline treatment of the wool leads to two unnatural dipeptide mimetics lysinoalanine (Lys(*) - Ala) and ornithinoalanine (Orn(*)- Ala) obtaining. They are result from the keratin hydrolysis process. The changes of wool keratin make it resistant to sulphide degradation. We synthesized and characterized these unnatural dipeptides under the experimental conditions. The structures and mechanism of Lys(*) - Ala and Orn(*)- Ala obtaining were elucidated. The using of newly synthesized products as markers for control of wool's keratin changes during skin unhairing process was demonstrated. The developments have also been the result of economic and environmental pressures to meet environmental regulations.
authors.affiliation: University of Chemical Technology and Metallurgy, Department of Organic Chemistry, Blvd. Kliment Ohridski 8, Sofia 1756, Bulgaria. dancho_danalev@yahoo.com
authors.forename: Dantcho
authors.initials: D
authors.lastname: Danalev
authors.forename: Margarita
authors.initials: M
authors.lastname: Koleva
authors.forename: Dimitrina
authors.initials: D
authors.lastname: Ivanova
authors.forename: Lyubomir
authors.initials: L
authors.lastname: Vezenkov
authors.forename: Nikolay
authors.initials: N
authors.lastname: Vassilev
mesh_terms: D000409:Alanine / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D004151:Dipeptides / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D007633:Keratins / Q000737:chemistry*; D008241:Lysinoalanine / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D009952:Ornithine / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D012756:Sheep; D012867:Skin; D014935:Wool / Q000737:chemistry*
chemical_list: D004151:Dipeptides; C412145:ornithinoalanine; D008241:Lysinoalanine; D007633:Keratins; D009952:Ornithine; D000409:Alanine