title: Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens.
abstract: Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox.
authors.affiliation: NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University, Brazil.
authors.forename: Daniara Cristina
authors.initials: DC
authors.lastname: Fernandes
authors.forename: Luis Octávio
authors.initials: LO
authors.lastname: Regasini
authors.forename: José Carlos Rebuglio
authors.initials: JC
authors.lastname: Vellosa
authors.forename: Patrícia Mendonça
authors.initials: PM
authors.lastname: Pauletti
authors.forename: Ian
authors.initials: I
authors.lastname: Castro-Gamboa
authors.forename: Vanderlan Silva
authors.initials: VS
authors.lastname: Bolzani
authors.forename: Olga Maria Mascarenhas
authors.initials: OM
authors.lastname: Oliveira
authors.forename: Dulce Helena Siqueira
authors.initials: DH
authors.lastname: Silva
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D047309:Flavones; D016166:Free Radical Scavengers; D005960:Glucosides; D010851:Picrates; D013451:Sulfonic Acids; C529725:nitensoside A; C529726:nitensoside B; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D009195:Peroxidase