title: Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line.
abstract: Existence of cancer stem cell is regarded as a main reason for metastasis and/or recurrences. In this study, the cancer stem-like cell derived from TJ905 glioblastoma multiforme cell line was isolated successfully. However, it was observed that generating rate of the cancer stem-like cells was lower than that of TJ905 cells, that expression of the anti-apoptotic and multidrug resistance-associated protein (MRP) genes were paradoxical to the literatures, which showed the uncertainty of cancer stem cells, and that some stem cell was not the solo factor to maintain tumor growth and resist apoptosis and anti-tumor drugs.
authors.affiliation: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Zhao
authors.forename: Shou-Gang
authors.initials: SG
authors.lastname: Guo
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Jiang
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Zhang
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Wei
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
authors.forename: Jia-Shan
authors.initials: JS
authors.lastname: Zhao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis* / Q000235:genetics; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D002417:Cattle; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division; D045744:Cell Line, Tumor / Q000378:metabolism; D002469:Cell Separation; D003470:Culture Media / Q000494:pharmacology; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005312:Fetal Blood; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000096:biosynthesis / Q000235:genetics; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis / Q000235:genetics; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D018874:Spheroids, Cellular / Q000166:cytology; D000077022:Survivin
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D003470:Culture Media; D016895:Culture Media, Serum-Free; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; C107489:BIRC5 protein, human; C419866:BIRC7 protein, human; C114462:multidrug resistance-associated protein 3; C421109:multidrug resistance-associated protein 1