[Osteoporosis in diabetes].
The diabetes is at great risk of the osteoporosis, and the bone fragility unrelated to bone density forms the pathological conditions peculiar to diabetes. The factor participating in diabetic osteoporosis has a state of insulin action deficiency, a hyperglycemic state, diabetic complications, and so on. An osteoblastic cell function is deteriorated and the number of that is decreased by the absolute and relative insulin deficiency, and sustained hyperglycemia also decreases an osteoblastic cell function still more. Furthermore, the osteoclast-related bone resorption is also promoted through sorbitol accumulation in the cell by the hyperglycemia state. The expression of transcription factors regulating osteoblastic cell differentiation is restrained, and the apoptosis of those cells is promoted. As a result, osteoplasty is obstructed. In the bone, AGEs (advanced glycation endproducts) is produced in excess, and bone fragility is promoted by the ratio of the AGEs bridging with the collagen rising. The complications of diabetes, such as visual disorder and the neuropathy, raise the risk of the fall in the diabetic osteoporosis patient, therefore, they will have more chance of fractures.
Kumeda
Yasuro
Y
Jyurakukai Ohno Memorial Hospital, Department of Kidney Internal Medicine.
D000818:Animals; D017209:Apoptosis; D001862:Bone Resorption / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D048909:Diabetes Complications; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism; D007328:Insulin / Q000172:deficiency; D010006:Osteoblasts / Q000166:cytology; D010024:Osteoporosis / Q000209:etiology*; D012307:Risk Factors
D017127:Glycation End Products, Advanced; D007328:Insulin; D003094:Collagen