title: Early lung transplantation success utilizing controlled donation after cardiac death donors.
abstract: Donation-after cardiac death (DCD) donor organs have potential to significantly alleviate the shortage of transplantable lungs. However, only limited data so far describes DCD lung transplantation (LTx) techniques and results. This study aims to describe the Alfred Hospital's early and intermediate outcomes following DCD donor LTx. Following careful experimentation and consultation DCD guidelines were created to utilize Maastricht category III lung donors from either the ICU or operating room(OR), with a warm ischemic time(WIT) of <60 min. Between May 2006 and December 2007, 22 referred DCD donors led to 11 attempted retrievals after withdrawal, resulting in 8 actual bilateral LTx (2 donors did not arrest in prescribed period and 1 donor had nonacceptable lungs). ICU WIT = 38.4 min (range 20-54, OR WIT = 12.7 min (11-15), p < 0.05. Post-LTx, 1 pulmonary hypertensive patient required ECMO for PGD3. The mean group pO2/FiO2 ratio at 24 hours was 307.7 (240-507) with an ICU stay of 9.5 days (2-21) and ward stay of 21.5 days (11-76). All 8 survive at a mean of 311 days (10-573) with good performance status and lung function. In conclusion, the use of Maastricht category III lungs for human LTx is associated with acceptable early clinical outcomes.
authors.affiliation: Lung Transplant Service, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, Melbourne, Australia. g.snell@alfred.org.au
authors.forename: G I
authors.initials: GI
authors.lastname: Snell
authors.forename: B J
authors.initials: BJ
authors.lastname: Levvey
authors.forename: T
authors.initials: T
authors.lastname: Oto
authors.forename: R
authors.initials: R
authors.lastname: McEgan
authors.forename: D
authors.initials: D
authors.lastname: Pilcher
authors.forename: A
authors.initials: A
authors.lastname: Davies
authors.forename: S
authors.initials: S
authors.lastname: Marasco
authors.forename: F
authors.initials: F
authors.lastname: Rosenfeldt
mesh_terms: D000293:Adolescent; D000328:Adult; D003643:Death; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014019:Tissue Donors; D014021:Tissue Preservation; D009927:Tissue and Organ Procurement