title: Disseminated blue naevus and malignant blue naevus associated with excessive aromatase syndrome.
abstract: We report a case of a 17-year-old boy who had a giant congenital blue naevus with multiple satellite pigmented lesions. Later the patient developed melanoma arising in the pre-existing lesion. He also had gynaecomastia and was diagnosed as having aromatase excess syndrome. To our knowledge, the association of these two rare conditions has not been previously reported. Further studies should be performed to investigate this unusual combination, which may have a genetic, endocrine or local cutaneous link leading to its occurrence.
authors.affiliation: Department of Dermatology, Hospital das Clínicas, School of Medicine, University of Sao Paulo, Brazil. loboalice@hotmail.com
authors.forename: A Z C
authors.initials: AZ
authors.lastname: Lobo
authors.forename: R M
authors.initials: RM
authors.lastname: Martin
authors.forename: W
authors.initials: W
authors.lastname: Belda
authors.forename: M M
authors.initials: MM
authors.lastname: Michi
authors.forename: M
authors.initials: M
authors.lastname: Arnone
authors.forename: C
authors.initials: C
authors.lastname: Festa-Neo
authors.forename: M N
authors.initials: MN
authors.lastname: Sotto
authors.forename: M A C
authors.initials: MA
authors.lastname: Vilela
authors.forename: J A
authors.initials: JA
authors.lastname: Sanches
mesh_terms: D000293:Adolescent; D001141:Aromatase / Q000235:genetics / Q000378:metabolism*; D006177:Gynecomastia / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008297:Male; D018329:Nevus, Blue / Q000151:congenital / Q000235:genetics / Q000473:pathology*; D012875:Skin Diseases, Metabolic / Q000150:complications*; D012878:Skin Neoplasms / Q000151:congenital / Q000473:pathology*; D013577:Syndrome
chemical_list: D001141:Aromatase