IgA1 glycosylation in IgA nephropathy: as sweet as it can be.
Abnormally O-glycosylated IgA1 is likely to be involved in the pathogenesis of IgA nephropathy (IgAN). Buck et al. show that the enzyme activity and gene expression of specific glycosyltransferases, in purified B cells isolated from peripheral blood and bone marrow, is not reduced in IgAN patients. As only a small fraction of IgA in IgAN patients is abnormally glycosylated, it is probable that a more detailed molecular analysis at the single cell level is required to unravel the cause of this abnormality.
Eijgenraam
J W
JW
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. j.w.eijgenraam@lumc.nl
van Kooten
C
C
D001402:B-Lymphocytes / Q000378:metabolism; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*
D007070:Immunoglobulin A