The butyrylcholinesterase knockout mouse is obese on a high-fat diet.
Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5% fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11% fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.
Li
Bin
B
Eppley Institute, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA. binli@unmc.edu
Duysen
Ellen G
EG
Lockridge
Oksana
O
D000818:Animals; D001774:Blood Chemical Analysis; D002091:Butyrylcholinesterase / Q000235:genetics / Q000502:physiology*; D004041:Dietary Fats / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity; D009765:Obesity / Q000201:enzymology*
D004041:Dietary Fats; D002091:Butyrylcholinesterase