[Investigation of the prevalence of drug-induced gingival overgrowth in renal transplant recipients medicated with cyclosporine A or tacrolimus].
OBJECTIVE
To investigate the prevalence of gingival overgrowth(GO) in a group of renal transplant recipients medicated with cyclosporine A(CsA) in comparison to those medicated with tacrolimus(Tcr).


METHODS
107 renal transplant recipients ( 85 CsA and 25 Tcr) were recruited into this study. Demographic, pharmacologic and periodontal data was recorded. The prevalence and severity of GO were compared between the two groups. The data was analyzed by SPSS13.0 software package for independent sample t test, chi(2) test, Mann-Whitney U test and stepwise regression analysis.


RESULTS
The prevalence of GO in the CsA group(49%)was significantly higher than that in the Tcr group(16%)(P<0.05). The CsA group showed a higher mean GO score (30.3+/-15.5) compared with the Tcr group(17.5+/-9.6) (P<0.001).In addition, the patients with GO presented a significantly higher plaque index and papilla bleeding index than those without GO in two groups(P<0.05).


CONCLUSIONS
The prevalence of GO is higher in renal transplant recipients taking CsA compared to Tcr. Plaque-induced gingival inflammation has a close relation with the severity of GO.
Gong
Yi-Ming
YM
Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xu
Ming
M
Gu
Zhang-Yu
ZY
D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D003773:Dental Plaque; D003774:Dental Plaque Index; D019214:Gingival Overgrowth / Q000139:chemically induced*; D005891:Gingivitis; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use; D066027:Transplant Recipients
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus