title: Seroprevalence of antibodies to varicella-zoster virus in Madrid (Spain) in the absence of vaccination.
abstract: OBJECTIVE
  to ascertain the seroprevalence of antibodies to varicella-zoster virus in the Madrid population prior to the introduction of vaccination.
  
  
  METHODS
  Cross-sectional antibody seroprevalence study.
  
  
  METHODS
  
  
  
  METHODS
  persons aged 2 to 40 years in Madrid. Field work: September 1999 to April 2000. Data were collected on demographic and socio-economic variables and on a number of exposures. IgG antibodies were determined using Enzyme Linked ImmunoSorbent Assay (ELISA), and antibody prevalence broken down by age group. Logistic regression was used to analyse the association between the presence of antibodies and the respective study variables. The results were compared against those of an earlier seroprevalence survey in Madrid (1993).
  
  
  RESULTS
  A total of 2,131 subjects were included, with a non-response rate of 20.4%. Antibody prevalence was estimated at 90.2%; the 90% mark was reached at 11 years of age and almost 100% of adults presented with antibodies. In the case of children, school attendance associated with the presence of antibodies. No significant differences were observed vis-à-vis the results of the earlier survey.
  
  
  CONCLUSIONS
  The seroprevalence profile coincides with those of other Spanish regions and European countries, and remains stable over time. Antibody presence rises sharply in children from aged 2 years to adolescence. Further seroprevalence studies are called for to study the disease trend and assess preventive measures.
authors.affiliation: Epidemiology Department, Madrid Public Health Institute, Madrid, Spain. napo@napo.jazztel.es
authors.forename: Napoleon
authors.initials: N
authors.lastname: Perez-Farinos
authors.forename: Luis
authors.initials: L
authors.lastname: Garcia-Comas
authors.forename: Rosa
authors.initials: R
authors.lastname: Ramirez-Fernandez
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Sanz
authors.forename: Dolores
authors.initials: D
authors.lastname: Barranco
authors.forename: Cristina
authors.initials: C
authors.lastname: Garcia-Fernandez
authors.forename: Maria
authors.initials: M
authors.lastname: Ordobas
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000097:blood; D002644:Chickenpox / Q000097:blood / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006562:Herpes Zoster / Q000097:blood / Q000453:epidemiology*; D014645:Herpesvirus 3, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G