[Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions].
OBJECTIVE
To explore the effect of electroacupuncture on heroin seeking behavior and FosB expression in relevant brain regions.


METHODS
Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention group, and a electroacupuncture group. The heroin seeking behavior was elicited by a small dose of heroin. FosB expression in relevnt brain region was assessed with immunohistochemical technique.


RESULTS
Tests on reinstatement of drug seeking behavior induced by heroin priming showed that compared with the restraint group, active pokes in the electroacupuncture group decreased significantly(P<0.05). Compared with the restraint group, the expression of FosB positive nuclei in Acd, Pcg and CeA of rats brain both in the electroacupuncture group and the needle retention group (P<0.05) decreased significantly. In LC, the expression of FosB positive nuclei in the needle retention group decreased significantly compared with the restraint group (P<0.05).


CONCLUSIONS
Continuous acupuncture and needle retention attentuate the reinstatement of heroin-seeking behaviors induced by heroin priming, and the inhibitory effect may be mediated partially by the expression of FosB in relevant regions which are involved in the process of heroin addiction.
Wang
Yu-hong
YH
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
Zeng
Li-bo
LB
Liu
Yi-jun
YJ
Hao
Wei
W
Zhang
Fu-qiang
FQ
Zhou
Wen-hua
WH
Liu
Hui-fen
HF
Tang
Shuai-en
SE
Yang
Guo-dong
GD
Chen
Hong-xian
HX
D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D015671:Electroacupuncture / Q000379:methods*; D006556:Heroin Dependence / Q000378:metabolism* / Q000523:psychology / Q000628:therapy*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
C483820:Fosb protein, rat; D016760:Proto-Oncogene Proteins c-fos