title: Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats.
abstract: OBJECTIVE
  Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non-steroidal anti-inflammatory drugs or Helicobacter pylori-induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid-induced gastric ulcer model, we investigated the protective effects of Artemisia asiatica extracts against ethanol-induced gastric mucosal injury.
  
  
  METHODS
  Sprague-Dawley rats received 4 g/kg body weight (BW) of absolute ethanol intragastrically, which produced visible hemorrhagic gastric lesions 60 min later.
  
  
  RESULTS
  In this animal setting, the pretreatment of Artemisia extracts (30 or 100 mg/kg BW), 1 h before ethanol administration, significantly attenuated the source of gastric injury, which was assessed with gross and microscopic analysis (P < 0.01). Protection from alcohol-induced damage with Artemisia pretreatment was associated with significantly decreased lipid peroxidation, protecting gastric mucosa from glutathione depletion, as well as the inhibition of the cytochrome 2E1 ethanol-metabolizing enzyme. It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
  
  
  CONCLUSIONS
  The data suggest that the ethanol extracts of Artemisia asiatica exerted significant protection from alcohol-induced gastric mucosal injury through bio-regulation, which is essential for cytoprotection and anti-inflammation.
authors.affiliation: Digestive Disease Center and DMC-MECOX Biomedical Research Center, Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sang Woon
authors.initials: SW
authors.lastname: Park
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Oh
authors.forename: Yong Seok
authors.initials: YS
authors.lastname: Kim
authors.forename: Hyejin
authors.initials: H
authors.lastname: Sim
authors.forename: Sang Jong
authors.initials: SJ
authors.lastname: Park
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Jang
authors.forename: Joo Sang
authors.initials: JS
authors.lastname: Park
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Baik
authors.forename: Ki Baik
authors.initials: KB
authors.lastname: Hahm
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019306:Artemisia; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol