Improved procedure for the bimolecular oxidative amidation of phenols.
Trifluoroacetic acid (TFA) is an effective promoter of the bimolecular Ritter-like oxidative amidation of 4-substituted phenols induced by PhI(OAc) 2 in MeCN. This suppresses the need for fluoroalcohol cosolvents, increases the yields, and facilitates isolation/purification procedures.
Liang
Huan
H
Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada.
Ciufolini
Marco A
MA
D000577:Amides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry*
D000577:Amides; D010636:Phenols