Synthesis of a new intermediate for bioactive Lamellarins.
This paper reports two methods of synthesis for 1,2,4-trimethoxy-5-(1-methyl-2-phenyl-vinyl)-benzene, which was a key intermediate to synthesize the various Lamellarins. One method is by using the Wittig-Horner reaction and another is by the Grignard reaction. By conducting contrast experiments, we got the optimal reaction parameters for high yields. The newly formed intermediate was identified by means of IR spectrum, (1)H-NMR, (13)C-NMR and melting point measurements.
He
Yu-Rong
YR
Liaoning Key Laboratory of Bio-Organic Chemistry, Dalian University, Dalian 116622, People's Republic of China.
You
Ye-Cheng
YC
Hu
Jie-Han
JH
Wang
Ai-Ling
AL
Yu
Xiao-Song
XS
Hu
Dai-Hua
DH
D001672:Biocompatible Materials / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D008422:Materials Testing; D044366:Transition Temperature
D001672:Biocompatible Materials; D003374:Coumarins