A novel molluscicidal formulation of niclosamide.
Snail control by molluscicides is an important strategy for schistosomiasis control in China. Currently, only one chemical molluscicide, niclosamide, which is used as 50% wettable powder of niclosamide ethanolamine salt (WPN), is commercially available for field snail control in China. However, WPN is costly, toxic, and has a lower dispersibility and precipitates rapidly. In this paper, we describe the development of a novel formulation of niclosamide, a suspension concentrate of niclosamide (SCN). The efficacy of SCN was evaluated both in the laboratory and field. SCN showed better molluscicidal effects than conventional formulation of WPN, as determined by LC(50) for adult snails, young snails, and snail eggs. The acute toxicity of SCN to Brachdanio rerio hamiton was less than WPN. In conclusion, the novel formulation of SCN suspension is physically more stable, more effective, and less toxic. Therefore, it can be more useful for controlling snails in endemic areas of schistosomiasis in China.
Dai
Jian-Rong
JR
Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, People's Republic of China.
Wang
Wei
W
Liang
You-Sheng
YS
Li
Hong-Jun
HJ
Guan
Xiao-Hong
XH
Zhu
Yin-Chang
YC
D000818:Animals; D002626:Chemistry, Pharmaceutical; D002681:China; D008975:Molluscacides / Q000737:chemistry* / Q000633:toxicity*; D009534:Niclosamide / Q000737:chemistry* / Q000633:toxicity*; D012552:Schistosomiasis / Q000517:prevention & control / Q000635:transmission; D012908:Snails / Q000187:drug effects* / Q000254:growth & development; D018675:Toxicity Tests; D015027:Zebrafish / Q000254:growth & development
D008975:Molluscacides; D009534:Niclosamide