Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
BACKGROUND
Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear.


OBJECTIVE
The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk.


METHODS
This was a multicenter prospective study of 142,520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake.


RESULTS
After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish.


CONCLUSIONS
The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.
Crowe
Francesca L
FL
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom. francesca.crowe@ceu.ox.ac.uk
Key
Timothy J
TJ
Appleby
Paul N
PN
Travis
Ruth C
RC
Overvad
Kim
K
Jakobsen
Marianne U
MU
Johnsen
Nina F
NF
Tjønneland
Anne
A
Linseisen
Jakob
J
Rohrmann
Sabine
S
Boeing
Heiner
H
Pischon
Tobias
T
Trichopoulou
Antonia
A
Lagiou
Pagona
P
Trichopoulos
Dimitrios
D
Sacerdote
Carlotta
C
Palli
Domenico
D
Tumino
Rosario
R
Krogh
Vitorrio
V
Bueno-de-Mesquita
H Bas
HB
Kiemeney
Lambertus A
LA
Chirlaque
Maria-Dolores
MD
Ardanaz
Eva
E
Sánchez
Maria-José
MJ
Larrañaga
Nerea
N
González
Carlos A
CA
Quirós
José R
JR
Manjer
Jonas
J
Wirfält
Elisabet
E
Stattin
Pär
P
Hallmans
Göran
G
Khaw
Kay-Tee
KT
Bingham
Sheila
S
Ferrari
Pietro
P
Slimani
Nadia
N
Jenab
Mazda
M
Riboli
Elio
E
D000368:Aged; D003611:Dairy Products; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects; D005060:Europe / Q000453:epidemiology; D005247:Feeding Behavior; D006801:Humans; D008297:Male; D008460:Meat / Q000009:adverse effects; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D017747:Seafood; D011795:Surveys and Questionnaires
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated