Aplysinoplides A-C, cytotoxic sesterterpenes from the marine sponge Aplysinopsis digitata.
Three sesterterpenoids, aplysinoplides A-C (1- 3), were isolated from the marine sponge Aplysinopsis digitata. Their structures were determined on the basis of spectroscopic data. They exhibited cytotoxic activity against P388 mouse leukemia cells.
Ueoka
Reiko
R
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Nakao
Yoichi
Y
Fujii
Shinobu
S
van Soest
Rob W M
RW
Matsunaga
Shigeki
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D054830:Sesterterpenes; C531294:aplysinoplide A; C531295:aplysinoplide B; C531296:aplysinoplide C