CO-opting the host HO-1 pathway in tuberculosis and malaria.
Infection with Mycobacterium tuberculosis and Plasmodium species results in upregulation of the host heme oxygenase-1 pathway. In tuberculosis infection, this leads to upregulation of the bacterial "dormancy regulon," whereas in malaria, it enhances the efficiency with which sporozoites develop into exoerythrocytic stages. Here we discuss these findings as well as some of the interesting questions they raise.
Sinnis
Photini
P
Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Ernst
Joel D
JD
D000818:Animals; D002248:Carbon Monoxide / Q000276:immunology; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010961:Plasmodium / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
D002248:Carbon Monoxide; D051547:Heme Oxygenase-1