Disrupted-in-Schizophrenia-1.
Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene.
Muir
Walter J
WJ
Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland EH10 5HF, United Kingdom. walter.muir@ed.ac.uk
Pickard
Benjamin S
BS
Blackwood
Douglas H R
DH
D000818:Animals; D001714:Bipolar Disorder / Q000235:genetics; D002869:Chromosome Aberrations; D019457:Chromosome Breakage; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D003865:Major Depressive Disorder / Q000235:genetics; D006580:Genetic Carrier Screening; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D051379:Mice; D018345:Mice, Knockout; D020412:Multifactorial Inheritance; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010641:Phenotype; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D014178:Translocation, Genetic
C412476:DISC1 protein, human; D005819:Genetic Markers; D009419:Nerve Tissue Proteins