Learning to recognize visual objects with microstimulation in inferior temporal cortex.
The malleability of object representations by experience is essential for adaptive behavior. It has been hypothesized that neurons in inferior temporal cortex (IT) in monkeys are pivotal in visual association learning, evidenced by experiments revealing changes in neural selectivity following visual learning, as well as by lesion studies, wherein functional inactivation of IT impairs learning. A critical question remaining to be answered is whether IT neuronal activity is sufficient for learning. To address this question directly, we conducted experiments combining visual classification learning with microstimulation in IT. We assessed the effects of IT microstimulation during learning in cases where the stimulation was exclusively informative, conditionally informative, and informative but not necessary for the classification task. The results show that localized microstimulation in IT can be used to establish visual classification learning, and the same stimulation applied during learning can predictably bias judgments on subsequent recognition. The effect of induced activity can be explained neither by direct stimulation-motor association nor by simple detection of cortical stimulation. We also found that the learning effects are specific to IT stimulation as they are not observed by microstimulation in an adjacent auditory area. Our results add the evidence that the differential activity in IT during visual association learning is sufficient for establishing new associations. The results suggest that experimentally manipulated activity patterns within IT can be effectively combined with ongoing visually induced activity during the formation of new associations.
Kawasaki
Keisuke
K
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.
Sheinberg
David L
DL
D000818:Animals; D001522:Behavior, Animal; D004193:Discrimination Learning / Q000502:physiology*; D004558:Electric Stimulation; D007839:Functional Laterality; D008253:Macaca mulatta; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D011601:Psychophysics; D013702:Temporal Lobe / Q000528:radiation effects*; D014795:Visual Pathways / Q000502:physiology*