Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease.
Beta-amyloid (Abeta)likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, Abeta associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of Abeta formation and then discusses the role of food-derived polyphenols as putative anti-amyloid drugs.
Bastianetto
S
S
Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Verdun, Québec, Canada H4H 1R3. stephane.bastianetto@douglas.mcgill.ca
Krantic
S
S
Quirion
R
R
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols
D016229:Amyloid beta-Peptides; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols