Cholestatic liver injury associated with whey protein and creatine supplements.
We present a case of acute cholestatic liver injury associated with the combination of whey protein and creatine supplements. The difficulty of diagnosing drug-induced liver injury is emphasized. The patient is a healthy, 27-year-old man who presented with painless jaundice. He had no occupational exposures to solvents, was not taking prescription medications, and did not use recreational drugs or alcohol. He was an enthusiastic weight-lifter and had been taking creatine for 8 to 9 months and whey protein supplements for 4 weeks prior to the development of symptoms. Laboratory tests revealed elevated total bilirubin (54.7 mg/dL) and alkaline phosphatase (436 U/L), minimally elevated transaminases, and a creatinine of 3.1 mg/dL. Serologic work-up was negative for viral hepatitis and autoimmune liver disease, and Wilson's disease was ruled out. Magnetic resonance cholangiopancreatogram was unremarkable, but a liver biopsy showed marked cholestasis with ductular proliferation. He had dramatic clinical improvement with intravenous fluids and discontinuation of the nutritional supplements. In patients with acute liver injury, clinicians should inquire about dietary supplement usage and consider immediate discontinuation of all unnecessary products. We describe a case of profound jaundice related to a commonly used and reportedly safe combination of such supplements.
Whitt
Kerry N
KN
Department of Medicine, Division of Liver Diseases, The Mount Sinai Medical Center, New York, NY 10029, USA. kerry.whitt@mssm.edu
Ward
Stephen C
SC
Deniz
Kemal
K
Liu
Lawrence
L
Odin
Joseph A
JA
Qin
Lihui
L
D000328:Adult; D002779:Cholestasis / Q000139:chemically induced*; D003401:Creatine / Q000009:adverse effects*; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male; D008894:Milk Proteins / Q000009:adverse effects*; D014891:Weight Lifting; D000067816:Whey Proteins
D008894:Milk Proteins; D000067816:Whey Proteins; D003401:Creatine