Detection of silent gaps in white noise following cortical deactivation in rats.
Rodent studies using cortical removal techniques, ranging from transient deactivation to surgical ablation of cortex, reveal the importance of auditory cortical integrity in detecting short silent gaps in white noise (2-15 ms). Processing limits for longer gaps under decorticate conditions in rats remain unknown. Determining the temporal threshold for subcortical resolution of gaps in noise could, however, shed light on both normal hierarchical processing of acoustic temporal stimuli, as well as the etiology of processing anomalies following developmental cortical disruption. To address these important issues, we assessed whether intact rats, as well as those with induced developmental cortical disruptions (microgyria) could resolve silent gaps of 20-100 ms in duration when embedded in white noise, during functional deactivation of auditory cortex. Results showed that both intact rats, as well as those with cortical malformations resulting from early focal disruptions of neuronal migration could resolve silent gaps of 100-ms duration under cortical deactivation (KCl). However, only intact rats could reliably detect 75-ms gaps, suggesting possible subcortical anomalies in subjects with early cortical disturbances.
Threlkeld
Steven W
SW
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, Storrs, Connecticut 06269-1020, USA.
Penley
Stephanie C
SC
Rosen
Glenn D
GD
Fitch
Roslyn Holly
RH
D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D016477:Artifacts; D001303:Auditory Cortex / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology*; D001309:Auditory Threshold / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D002465:Cell Movement; D003399:Craniotomy; D003714:Denervation; D005615:Freezing; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D011189:Potassium Chloride