title: Recurrent mutation in SNPs within Y chromosome E3b (E-M215) haplogroup: a rebuttal.
abstract: In a previous issue of AJHB, Fernandes et al. (2008. Am J Hum Biol 20:185-190.) describe instances of identity by state at multiple short tandem repeat loci between human Y chromosomes belonging to different E-M35 sub-haplogroups. They interpret these findings as evidence for multiple mutational events in at least two loci (M78 and M81). Here, we introduce a novel polymorphic marker (V68), potentially useful to investigate the issue. This marker and sequence data, reported here for the first time, reinforce our previous interpretations on the phylogenetic structure of the E3b haplogroup. We discuss these results in the frame of general approaches to attain robust phylogenetic inferences based on biallelic polymorphism data.
authors.affiliation: Department of Genetics and Molecular Biology, Sapienza Università di Roma, Rome 00185, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Cruciani
authors.forename: Beniamino
authors.initials: B
authors.lastname: Trombetta
authors.forename: Andrea
authors.initials: A
authors.lastname: Novelletto
authors.forename: Rosaria
authors.initials: R
authors.lastname: Scozzari
mesh_terms: D044383:Black People / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009154:Mutation; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers