[Osteoporosis and fractures associated with drugs].
Drugs can affect the skeleton in different ways. Antiepileptic drugs were not associated with any major fracture risk. Lithium was associated with a decreased fracture risk. Insulin, sulphonylureas and metformin were associated with a decreased risk, whereas glitazones were associated with an increased risk. Blood pressure lowering drugs, thiazide diuretics and nitroglycerin were associated with a decreased risk of fractures, whereas amiodarone and loop diuretics were associated with an increased risk. Pain medication varied from no effect to an increased fracture risk.
Vestergaard
Peter
P
Arhus Sygehus, Osteoporoseklinikken, Arhus C. p-vest@post4.tele.dk
Rejnmark
Lars
L
Mosekilde
Leif
L
D000700:Analgesics / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D015519:Bone Density / Q000187:drug effects; D002317:Cardiovascular Agents / Q000009:adverse effects; D002491:Central Nervous System Agents / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005598:Fractures, Spontaneous / Q000139:chemically induced*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects; D010024:Osteoporosis / Q000139:chemically induced*; D012307:Risk Factors
D000700:Analgesics; D000970:Antineoplastic Agents; D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D007004:Hypoglycemic Agents