title: The use of glucan as immunostimulant in the treatment of a severe case of chromoblastomycosis.
abstract: We report the case of an alternative treatment for a patient with a severe form of chromoblastomycosis that responded poorly to the traditional antifungal therapy. We hereby show, in this study, the improvement of lesions after treatment with itraconazole associated with an intramuscular administration of glucan. We observed that the regression of lesions was associated with an improvement of the cellular immune response. This favourable response that we observed suggests that the therapeutic regimen we used might be an option for the treatment of patients with a severe form of chromoblastomycosis.
authors.forename: Conceição de Maria Pedrozo e Silva
authors.initials: Cde M
authors.lastname: Azevedo
authors.forename: Sirley Garcia
authors.initials: SG
authors.lastname: Marques
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Resende
authors.forename: Azizedite Guedes
authors.initials: AG
authors.lastname: Gonçalves
authors.forename: Daniel Vagner de Castro Lima
authors.initials: DV
authors.lastname: Santos
authors.forename: Raimunda Ribeiro
authors.initials: RR
authors.lastname: da Silva
authors.forename: Maria da Glória Teixeira
authors.initials: Mda G
authors.lastname: de Sousa
authors.forename: Sandro Rogerio
authors.initials: SR
authors.lastname: de Almeida
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002862:Chromoblastomycosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005936:Glucans / Q000276:immunology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D000276:Adjuvants, Immunologic; D000935:Antifungal Agents; D005936:Glucans; D017964:Itraconazole