Cognitive dysfunction associated with elemental mercury ingestion and inhalation: a case study.
A 63-year-old man with a history of alcohol dependence ingested elemental mercury as a suicide gesture. Serial abdominal X-rays showed gradual but incomplete clearance of mercury from the colon. Routine chest X-ray showed evidence of punctate radiopaque materials in the lower lobe of the right lung. Blood and urine mercury levels both exceeded thresholds considered to be associated with cognitive dysfunction. Elicited cognitive deficits were most prominent in processing speed, flexibility, and response inhibition. Semantic fluency, visuospatial processing, and recall memory for visual and low-context verbal material were also affected. The deficits may have been attributable primarily to alcohol abuse. Elemental mercury is not readily absorbed from the gastrointestinal tract; however, mercury vapor, which was inhaled inadvertently, readily crosses the blood-brain barrier and is neurotoxic. We argue, therefore, that mercury toxicity is more likely than not to have been a factor contributing to the patient's cognitive dysfunction.
Cercy
Steven P
SP
Mental Health Service, Veterans Affairs New York Harbor Healthcare System, New York Campus, USA.
Wankmuller
Michelle M
MM
D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology*; D003106:Colon / Q000473:pathology; D006801:Humans; D001239:Inhalation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008630:Mercury Poisoning / Q000097:blood / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed / Q000379:methods