[The assay of intracelluar cytidine deaminase activity and its clinical significance in patient with acute leukemia].
OBJECTIVE
To investigate the relationship between the intracellular cytidine deaminase (CDD) activity and drug resistance in acute leukemia (AL) of different stage.


METHODS
CDD activity of 80 AL patients was determined by radioactive isotope assay.


RESULTS
CDD activity of previously untreated and refractory/relapse AL patients was much higher than that of patients in complete remission (P<0.05). There was no significant difference of CDD activity between previously untreated and refractory/relapse patients (P>0.05). The activity of CDD had no correlation with age, sex, classification of AL and effect of chemotherapy containing cytidine deaminase (Ara-C).


CONCLUSIONS
Intracellular CDD activity in AL patients may be related to the stages of the disease. It seemed that CDD might not be considered as an independent predictive factor for the drug healing efficacy of Ara-C.
Zhao
Xiao Su
XS
Institute of Hematology, Peking University Peopleos Hospital, Beijing 100044, China.
Sun
Zhi qiang
Zq
Jiang
Bin
B
Wang
De bing
de B
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology; D003564:Cytidine Deaminase / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007424:Intracellular Fluid / Q000201:enzymology*; D007938:Leukemia / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D003564:Cytidine Deaminase