title: Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review.
abstract: Adenoid cystic carcinoma, also called cylindroma, is the second most common histological type of tracheal malignancy but represents 1% of all respiratory tract cancers. We report a case of a 59-year-old patient submitted to an incomplete resection of the trachea and subsequently treated with adjuvant tomotherapy. There have been no reports in the literature regarding intensity-modulated radiation therapy with linac or tomotherapy systems in adenoid cystic carcinoma of the trachea. The present clinical case demonstrates the feasibility of adjuvant intensity-modulated radiation therapy techniques for optimizing the dose coverage of the tumor bed while sparing surrounding normal tissues. A dosimetric comparison between the tomotherapy plan and a 3-dimensional conformal radiotherapy plan is also reported. We demonstrate that tomotherapy permits an increase in the dose per fraction without important acute adverse effects. At 24 months' follow-up, our patient shows no evidence of disease with negative histological findings.
authors.affiliation: Department of Radiation Oncology, Istituto Scientifico Fondazione San Raffaele, Milan, Italy. filippo.alongi@hsr.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Alongi
authors.forename: Nadia
authors.initials: N
authors.lastname: Di Muzio
authors.forename: Micaela
authors.initials: M
authors.lastname: Motta
authors.forename: Sara
authors.initials: S
authors.lastname: Broggi
authors.forename: Elena
authors.initials: E
authors.lastname: De Martin
authors.forename: Angelo
authors.initials: A
authors.lastname: Bolognesi
authors.forename: Mauro
authors.initials: M
authors.lastname: Cattaneo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Calandrino
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Fazio
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D014134:Tracheal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome