Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance.
In this review, we discuss current views of the bone marrow (BM) stem cell (SC) compartment and present data showing that BM contains heterogeneous populations of hematopoietic (H)SCs and non-HSCs. These cells are variously described in the literature as: endothelial progenitor cells (EPCs); mesenchymal (M)SCs; multipotent adult progenitor cells (MAPCs); marrow-isolated adult multilineage inducible (MIAMI) cells; and multipotent adult (MA)SCs. In some cases, it is likely that similar or overlapping populations of primitive SCs in the BM detected using various experimental strategies were assigned different names. Recently, we purified rare CXC chemokine receptor 4 expressing (CXCR4(+)) small SCs from the murine BM that express markers characteristic for embryonic (E)SCs, epiblast (EP)SCs, and primordial germ cells (PGCs). We named these primitive cells very small embryonic-like (VSEL) SCs. Our data indicate that VSELs may differentiate into cells from all three germ layers.
Ratajczak
Mariusz Z
MZ
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA. mzrata01@louisville.edu
Zuba-Surma
Ewa K
EK
Machalinski
Bogdan
B
Ratajczak
Janina
J
Kucia
Magda
M
D000328:Adult; D000818:Animals; D015415:Biomarkers; D001854:Bone Marrow Cells / Q000166:cytology* / Q000502:physiology; D002454:Cell Differentiation; D002469:Cell Separation / Q000379:methods; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000502:physiology; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D016256:Lewis X Antigen; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D039902:Multipotent Stem Cells / Q000166:cytology / Q000502:physiology; D050814:Octamer Transcription Factor-3; D009928:Organ Specificity; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology; D019718:Receptors, CXCR4
D015415:Biomarkers; D016256:Lewis X Antigen; D050814:Octamer Transcription Factor-3; D019718:Receptors, CXCR4