Cystatin C and creatinine in an HIV cohort: the nutrition for healthy living study.
BACKGROUND
Human immunodeficiency virus (HIV)-infected persons have an increased risk of chronic kidney disease (CKD). Serum creatinine level may underestimate the prevalence of CKD in subjects with decreased lean body mass or liver disease. Level of serum cystatin C, an alternative kidney function marker, is independent of lean body mass.


METHODS
Cross-sectional.


METHODS
250 HIV-infected subjects on highly active antiretroviral therapy in the Nutrition for Healthy Living (NFHL) cohort; 2,628 National Health and Nutrition Examination Survey (NHANES) 2001-2002 subjects.


METHODS
Comparison of serum creatinine levels in NFHL to those in NHANES subjects; comparison of CKD in NFHL subjects ascertained using serum creatinine versus cystatin C levels.


METHODS
Standardized serum creatinine, serum cystatin C, glomerular filtration rate (GFR) estimated from serum creatinine and cystatin C levels.


RESULTS
Creatinine levels were lower in NFHL than NHANES subjects despite greater rates of hepatitis, diabetes, and drug use (mean difference, -0.18 mg/dL; P < 0.001 adjusted for age, sex, and race). Of NFHL subjects, only 2.4% had a creatinine-based estimated GFR less than 60 mL/min/1.73 m(2), but 15.2% had a cystatin-based estimated GFR less than 60 mL/min/1.73 m(2).


CONCLUSIONS
GFR was estimated rather than measured. Other factors in addition to GFR may affect creatinine and cystatin C levels. Measurements of proteinuria were not available.


CONCLUSIONS
Serum creatinine levels may overestimate GFRs in HIV-infected subjects. Kidney disease prevalence may be greater than previously appreciated.
Jones
Clara Y
CY
Tufts University School of Medicine, Boston, MA 02111, USA. clara.jones@tufts.edu
Jones
Camille A
CA
Wilson
Ira B
IB
Knox
Tamsin A
TA
Levey
Andrew S
AS
Spiegelman
Donna
D
Gorbach
Sherwood L
SL
Van Lente
Frederick
F
Stevens
Lesley A
LA
D000328:Adult; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009752:Nutritional Status; D015995:Prevalence; D011446:Prospective Studies
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine