Lipidomics: new approaches to the studies of cell signaling and prospects of use in medicine.
A new modern stage in the development of lipid biochemistry is presented: lipidomics, which emerged on the basic of new highly sensitive fractionation methods, primarily, mass spectroscopy. Lipidomics is defined mainly as systemic evaluation of all molecular types of lipids in an object, their cell functions, and molecules with which they react. Lipidomic approaches identifying picomole levels of individual lipids in combination with modern genome technology provide detailed information about the involvement of minor phospholipids in the cell signaling processes. Brief data on the functions of lysophospholipids as second messengers of signal transfer, their effects on cell processes, and possible involvement in the pathogenesis of some diseases are presented. It is expected that introduction of lipidomics in biomedical studies will promote the detection of targets for new drugs and development of new diagnostic tests.
Torkhovskaya
T I
TI
Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow. torti@mail.ru
Khalilov
E M
EM
Korotaeva
A A
AA
D035843:Biomedical Research / Q000379:methods; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism; D008511:Medicine; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D008055:Lipids; D008246:Lysophospholipids; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins