title: A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses.
abstract: Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses.
authors.affiliation: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Hoelscher
authors.forename: Neetu
authors.initials: N
authors.lastname: Singh
authors.forename: Sanjay
authors.initials: S
authors.lastname: Garg
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Jayashankar
authors.forename: Vic
authors.initials: V
authors.lastname: Veguilla
authors.forename: Aseem
authors.initials: A
authors.lastname: Pandey
authors.forename: Yumi
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Katz
authors.forename: Ruben
authors.initials: R
authors.lastname: Donis
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Mittal
authors.forename: Suryaprakash
authors.initials: S
authors.lastname: Sambhara
mesh_terms: D000256:Adenoviridae / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006388:Hemagglutinins / Q000235:genetics / Q000276:immunology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008168:Lung / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D009698:Nucleoproteins / Q000235:genetics / Q000276:immunology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology / Q000494:pharmacology
chemical_list: D000914:Antibodies, Viral; D006388:Hemagglutinins; D007252:Influenza Vaccines; D009698:Nucleoproteins; D014614:Vaccines, Synthetic