title: Survival of cancer cells is maintained by EGFR independent of its kinase activity.
abstract: Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).
authors.affiliation: Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Weihua
authors.forename: Rachel
authors.initials: R
authors.lastname: Tsan
authors.forename: Wei-Chien
authors.initials: WC
authors.lastname: Huang
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Wu
authors.forename: Chao-Hua
authors.initials: CH
authors.lastname: Chiu
authors.forename: Isaiah J
authors.initials: IJ
authors.lastname: Fidler
authors.forename: Mien-Chie
authors.initials: MC
authors.lastname: Hung
mesh_terms: D001343:Autophagy; D016923:Cell Death; D002455:Cell Division; D002470:Cell Survival; D066246:ErbB Receptors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007700:Kinetics; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D034741:RNA, Small Interfering / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051269:Sodium-Glucose Transporter 1 / Q000502:physiology*
chemical_list: D034741:RNA, Small Interfering; C495674:SLC5A1 protein, human; D051269:Sodium-Glucose Transporter 1; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D005947:Glucose