[Gut microflora is a key player in host energy homeostasis].
Gut microflora is now considered as a key organ involved in host energy homeostasis. Recent data suggest that the alterations of the gut bacteria ecosystem could contribute to the development of metabolic disorders such as type 2 diabetes and obesity. First, gut microflora may increase energy efficiency of non digested food via the fermentation, thus providing more energy to the host. Secondly, fatty acids flux and storage in the adipose tissue is under the control of the fasting-induced adipocyte factor FIAF, which expression depends on gut microflora. Third, high-fat diet feeding changes gut bacteria profile, leading to a drop in bifidobacteria content, which correlates with a higher LPS plasma levels, thereby participating to the onset of inflammation, insulin resistance and type 2 diabetes associated with obesity. Changing gut microflora composition could be a useful tool to prevent or to treat high-fat/low fibres diet-induced metabolic syndrome. double dagger.
Delzenne
Nathalie M
NM
Université catholique de Louvain, Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Bruxelles, Belgique. UCL, Unit PMNT-7369, Avenue E. Mounier, 73/69, B-1200 Bruxelles, Belgique. nathalie.delzenne@uclouvain.be
Cani
Patrice D
PD
D001424:Bacterial Infections / Q000503:physiopathology; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D009765:Obesity / Q000453:epidemiology / Q000382:microbiology