title: Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes.
abstract: BACKGROUND
  Mean platelet volume (MPV) has been associated with the prognosis in stroke patients. However, its spontaneous variability during the acute phase of the disease is unknown. Materials and Methods - One hundred and thirty-seven patients with ischemic stroke, aged 75.4+/-11.0 (SD) years, were classified according to several criteria: National Institutes of Health Stroke Scale (NIHSS) score, maximum lesion diameter on CT scan, Oxfordshire Community Stroke Projects (OCSP) and Trial of ORG 10172 in Acute Stroke Treatment (TOAST) categories. Platelet parameters were determined 1.2 days after the onset of symptoms, and after 3.0 further days.
  
  
  RESULTS
  The initial MPV was higher in non-lacunar than lacunar strokes (8.30+/-1.10 vs. 7.95+/-0.79 fl, P=0.04), and correlated with the sampling delay with respect to the onset of symptoms, especially in the strokes with lesions >=4 cm (r=0.39, P=0.009), NIHSS >=11 (r=0.35, P=0.02) and of cardioembolic origin (r=0.35, P=0.01). Subsequently a late MPV increment was observed in the remaining categories: from 8.20 to 8.38 fl (P=0.02) in the strokes with lesions <4 cm, from 8.11 to 8.31 fl (P=0.01) in the presence of an NIHSS<11 and from 8.20 to 8.61 fl (P=0.03) when the occlusion of a large artery was involved.
  
  
  CONCLUSIONS
  Platelet volume is not stable during the acute phase in non-lacunar ischemic strokes, as it increases early in the most severe forms, and later in the remaining subtypes. The release of large and more reactive platelets may contribute to the thrombophilic state associated with ischemic events.
authors.affiliation: University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy. antonio.muscari@unibo.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Muscari
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Puddu
authors.forename: Andrea
authors.initials: A
authors.lastname: Cenni
authors.forename: Maria G
authors.initials: MG
authors.lastname: Silvestri
authors.forename: Rosa
authors.initials: R
authors.lastname: Giuzio
authors.forename: Marzia
authors.initials: M
authors.lastname: Rosati
authors.forename: Nadia
authors.initials: N
authors.lastname: Santoro
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Bianchi
authors.forename: Donatella
authors.initials: D
authors.lastname: Magalotti
authors.forename: Marco
authors.initials: M
authors.lastname: Zoli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000473:pathology*; D020520:Brain Infarction / Q000150:complications*; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D013997:Time Factors