Relationship between lipoprotein(a) and spontaneous recanalization of infarct-related arteries in the early phase of acute myocardial infarction.
BACKGROUND
Lipoprotein(a) (Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation.


OBJECTIVE
We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI).


METHODS
In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infarction (TIMI) grade, Group I (TIMI 0-1, n = 94) versus Group II (TIMI 2-3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given.


RESULTS
The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups.


CONCLUSIONS
The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI.
Kim
Jin Won
JW
Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea. kjwmm@medimail.co.kr
Seo
Hong Seog
HS
Suh
Soon Yong
SY
Choi
Cheol Ung
CU
Kim
Eung Ju
EJ
Rha
Seung-Woon
SW
Park
Chang Gyu
CG
Oh
Dong Joo
DJ
D000368:Aged; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy; D015425:Myocardial Reperfusion; D011859:Radiography; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014654:Vascular Patency / Q000502:physiology*
D017270:Lipoprotein(a)