title: Antimycobacterial substances from Phaeosphaeria sp BCC8292.
abstract: Eleven substances including naphthalenones, naphthoquinones, unsymmetrical naphthoquinone dimers and a chlorinated diphenyl ether, three of which are new, have been isolated from the fungus Phaeosphaeria sp. The absolute stereochemistry of naphthalenones has been determined by the Mosher and exciton chirality methods. The biological activity of these compounds against Mycobacterium tuberculosis and cytotoxicity against KB, BCA, NCI-H 187 and Vero cell lines were evaluated.
authors.affiliation: National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Klong Luang, Pathumthani, Thailand. pattamap@biotec.or.th
authors.forename: Pattama
authors.initials: P
authors.lastname: Pittayakhajonwut
authors.forename: Pairoh
authors.initials: P
authors.lastname: Sohsomboon
authors.forename: Aibrohim
authors.initials: A
authors.lastname: Dramae
authors.forename: Rapheephat
authors.initials: R
authors.lastname: Suvannakad
authors.forename: Sanisa
authors.initials: S
authors.lastname: Lapanun
authors.forename: Morakot
authors.initials: M
authors.lastname: Tantichareon
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001203:Ascomycota / Q000737:chemistry*; D002522:Chlorocebus aethiops; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D009281:Naphthalenes