title: Diffuse reflectance spectroscopy measurements for tissue-type discrimination during deep brain stimulation.
abstract: Diffuse reflectance spectroscopy as a method for improving intracerebral guidance during functional neurosurgery has been investigated. An optical probe was developed for measurements during stereotactic and functional neurosurgery in man. The aim of the study was to investigate the spectral differences between white and grey matter and between white matter and functional targets. Diffuse reflectance spectroscopy measurements in ten patients were recorded at incremental steps towards and in three different functional targets (STN, GPi and Zi). The recorded spectra along the trajectory were sorted into white or grey matter, based on preoperative MRI images or the recorded spectral shape and intensity. The difference between tissue types was calculated as a quotient. Significant intensity differences between white and grey matter were found to be at least 14% (p < 0.05) and 20% (p < 0.0001) for MRI and spectral-sorted data respectively. The reflectance difference between white matter and the functional targets of GPi was higher than for STN and Zi. The results indicate that diffuse reflectance spectroscopy has a potential to be developed to a suitable complement to other intracerebral guidance methods.
authors.affiliation: Department of Biomedical Engineering, Linköping University, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Antonsson
authors.forename: Ola
authors.initials: O
authors.lastname: Eriksson
authors.forename: Patric
authors.initials: P
authors.lastname: Blomstedt
authors.forename: A Tommy
authors.initials: AT
authors.lastname: Bergenheim
authors.forename: Marwan
authors.initials: M
authors.lastname: I Hariz
authors.forename: Johan
authors.initials: J
authors.lastname: Richter
authors.forename: Peter
authors.initials: P
authors.lastname: Zsigmond
authors.forename: Karin
authors.initials: K
authors.lastname: Wårdell
mesh_terms: D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis* / Q000628:therapy*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods*; D013813:Therapy, Computer-Assisted / Q000379:methods*