Targeting oxidative stress in surgery: effects of ageing and therapy.
In the current era cardiac surgeons are being called upon to operate upon older, sicker patients. The effect is to augment oxidative stress and increase the rate of post-operative complications and ultimately mortality. We have developed antioxidant-based pre-treatment regimes initially based on coenzyme Q(10). A randomised trial of coenzyme Q(10) in elective cardiac surgery patients demonstrated augmented plasma and cardiac mitochondrial membrane coenzyme Q(10) content, improved mitochondrial respiration and increased myocardial tolerance of oxidative stress. The addition of omega-3 polyunsaturated fatty acids, alpha-lipoic acid, selenium and magnesium orotate in a second clinical trial, improved post-operative recovery with demonstrable reductions in myocardial damage, rate of atrial fibrillation and length of hospital stay. Finally we performed a pilot study of this combined metabolic therapy regimen to which we added preoperative physical exercise and mental stress reduction with indications of further improvements in post-operative recovery. We conclude that simultaneously targeting a number of key deficiencies with a metabolic formulation prior to surgery results in peri- and post-operative clinical and economic benefits.
Pepe
Salvatore
S
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia; Department of Surgery, Monash University, Melbourne, Australia; Baker Heart Research Institute, Melbourne, Australia Melbourne, Australia.
Leong
Jee-Yoong
JY
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia; Department of Surgery, Monash University, Melbourne, Australia.
Merwe
Juliana Van der
JV
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia; Department of Surgery, Monash University, Melbourne, Australia.
Marasco
Silvana F
SF
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia; Department of Surgery, Monash University, Melbourne, Australia.
Hadj
Anthony
A
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia.
Lymbury
Robyn
R
Griffith University, Qld., Australia.
Perkins
Anthony
A
Griffith University, Qld., Australia.
Rosenfeldt
Franklin L
FL
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia; Department of Surgery, Monash University, Melbourne, Australia; Baker Heart Research Institute, Melbourne, Australia Melbourne, Australia.
D000375:Aging / Q000502:physiology*; D000975:Antioxidants / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods; D016032:Randomized Controlled Trials as Topic
D000975:Antioxidants