Insights into cellular microRNAs and human immunodeficiency virus type 1 (HIV-1).
Recent findings suggest that mammalian microRNAs (miRNAs) may influence viral replication in host cells. Studies on HIV-1 infection have contributed in part to the development of this notion. Herein, we review, in brief, some of the evidence supportive of an interplay between human miRNAs and HIV-1 in cells. Several cellular miRNAs potentially act to restrict HIV-1 replication, and the virus has countermeasures to evade such restriction.
Kumar
Ajit
A
Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, Washington, District of Columbia, USA.
Jeang
Kuan-Teh
KT
D000071480:APOBEC-3G Deaminase; D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D014779:Virus Replication / Q000502:physiology*
D035683:MicroRNAs; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase