title: The pharmacokinetics and interactions of ivermectin in humans--a mini-review.
abstract: Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief review of the information available regarding the pharmacokinetics and interactions of ivermectin in humans. Awareness of these characteristics could improve the clinical efficacy of Ivermectin. All Authors declare that they do not have any Conflict of interest and that the work is original. All Authors agree that the contents of the manuscript are confidential and will not be copyrighted, submitted, or published elsewhere (including the Internet), in any language, while acceptance by the Journal is under consideration.
authors.affiliation: Department of Biomedical Sciences, Veterinary Faculty, University of Leon, Campus de Vegazana s/n 24071, Leon, Spain. agonc@unileon.es
authors.forename: Aránzazu
authors.initials: A
authors.lastname: González Canga
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sahagún Prieto
authors.forename: M José
authors.initials: MJ
authors.lastname: Diez Liébana
authors.forename: Nélida
authors.initials: N
authors.lastname: Fernández Martínez
authors.forename: Matilde
authors.initials: M
authors.lastname: Sierra Vega
authors.forename: Juan J
authors.initials: JJ
authors.lastname: García Vieitez
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D004347:Drug Interactions / Q000502:physiology; D018565:Food-Drug Interactions / Q000502:physiology; D006801:Humans; D007559:Ivermectin / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010272:Parasitic Diseases / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin