UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA.
cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated.
Payet
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Centre de Biophysique Moléculaire CNRS, 1A avenue dela Recherche Scientifique Orléans cedex 2 F-45071 France.
Leng
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