Exploring feasibility of multicolored CdTe quantum dots for in vitro and in vivo fluorescent imaging.
We report the use of novel multicolored CdTe quantum dots (QDs) as fluorophores for biological fluorescence imaging. The CdTe QDs were prepared to exhibit emission wavelengths in the green, yellow, and red range by using trifluoroacetic acid (TFA), L-cysteine and thioglycolic acid (TGA) as surface stabilizers, respectively. The particles have good water solubility and photostability. Fluorescence imaging potential was evaluated in vitro and in vivo using a multispectral Maestro CRI Fluorescence Imaging system. The results show that different colored CdTe QDs allow sensitive detection simultaneously or separately both in vitro and in vivo against background fluorescence. The studies indicate that CdTe QDs can provide alternative fluorescent probes for biological imaging.
Su
Junfeng
J
College of Software, Nankai University, Tianjin 300071, PR China.
Zhang
Jun
J
Liu
Li
L
Huang
Yalou
Y
Mason
Ralph P
RP
D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000379:methods; D045663:Quantum Dots; D013691:Tellurium / Q000737:chemistry* / Q000633:toxicity
D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride