title: Presentation and prognosis of local recurrence after total mesorectal excision.
abstract: OBJECTIVE
  The aim of this study was to describe the presentation, treatment and prognosis of local recurrences following total mesorectal excision for rectal adenocarcinoma.
  
  
  METHODS
  Between 1999 and 2002, 201 patients were treated with total mesorectal excision for mid or low rectal cancer and were followed up prospectively.
  
  
  RESULTS
  Overall 2-year survival was 85%. The 2-year recurrence rate was 8%. Eighteen patients developed local recurrence at 3-60 months. Nine recurrences originated from the pelvic sidewall. These recurrences were symptomatic in 90% of patients. Only two patients were reoperated with a R0 resection and were alive without local recurrence after 19 and 31 months. The seven others died within 9 months. Nine recurrences originated from an anastomotic suture line. Only two had symptoms. A R0 surgical resection was performed in all patients with a 67% sphincter conservation rate. After 26-months of median follow-up (range 7-58), all patients were alive.
  
  
  CONCLUSIONS
  Half of the local recurrence after total mesorectal excision was located at the anastomotic site. Rectoscopic examination should be performed regularly to detect these anatomotic recurrences that are accessible to a R0 itérative resection.
authors.affiliation: Department of Surgery, AP-HP, Hôpital Ambroise Paré, Boulogne, France.
authors.forename: C
authors.initials: C
authors.lastname: de Chaisemartin
authors.forename: C
authors.initials: C
authors.lastname: Penna
authors.forename: D
authors.initials: D
authors.lastname: Goere
authors.forename: S
authors.initials: S
authors.lastname: Benoist
authors.forename: A
authors.initials: A
authors.lastname: Beauchet
authors.forename: C
authors.initials: C
authors.lastname: Julie
authors.forename: B
authors.initials: B
authors.lastname: Nordlinger
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology*; D012004:Rectal Neoplasms / Q000601:surgery*