Asymmetric total synthesis of (+)-phoslactomycin B.
(+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki-Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Delta12-double bond.
Shibahara
Setsuya
S
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Fujino
Masataka
M
Tashiro
Yasumasa
Y
Takahashi
Keisuke
K
Ishihara
Jun
J
Hatakeyama
Susumi
S
D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
D007783:Lactones; D009943:Organophosphorus Compounds; C060449:phoslactomycin B