Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx.
Isoprenylcysteine carboxyl methyltransferase (Icmt) is enzyme target in anticancer drug discovery. An Icmt natural product high-throughput screening campaign was conducted and a hit extract from the roots of Hovea parvicalyx was identified. 2'-Methoxy-3'-prenyl-licodione and 2'-methoxy-3',3''-diprenyl-licodione, two prenylated beta-hydroxychalcone compounds, together with the known flavanone (S)-glabrol, were isolated and identified as bioactive constituents. Their structures were determined largely by 1D and 2D NMR spectroscopy.
Buchanan
Malcolm S
MS
Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
Carroll
Anthony R
AR
Fechner
Gregory A
GA
Boyle
Anthony
A
Simpson
Moana
M
Addepalli
Rama
R
Avery
Vicky M
VM
Forster
Paul I
PI
Guymer
Gordon P
GP
Cheung
Tony
T
Chen
Huwei
H
Quinn
Ronald J
RJ
D000970:Antineoplastic Agents / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011496:Protein Methyltransferases; C056501:protein-S-isoprenylcysteine O-methyltransferase