title: Development of controlled release sildenafil formulations for vaginal administration.
abstract: Sildenafil is an active substance that has already been approved by FDA for human use. It is known to be an active compound for the treatment of sexual dysfunction in men. Some encouraging results have been published concerning the treatment of infertility with sildenafil in women, but there is no pharmaceutical preparation available. Therefore, various formulations were prepared and the most suitable sildenafil release was found to be with the sildenafil-containing suppositories prepared using Eudragit RS100 and Witepsol H15. The vaginal insert with EVAC 210 polymer containing sildenafil has also provided sildenafil release for a longer period.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Technology, Gazi University, Ankara, Turkey. tunc@tr.net
authors.forename: I Tuncer
authors.initials: IT
authors.lastname: Değim
authors.forename: Fatmanur
authors.initials: F
authors.lastname: Tuğcu-Demiröz
authors.forename: Sibel
authors.initials: S
authors.lastname: Tamer-Ilbasmis
authors.forename: Füsun
authors.initials: F
authors.lastname: Acartürk
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000282:Administration, Intravaginal; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000737:chemistry*; D013488:Suppositories; D013607:Tablets; D014280:Triglycerides / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011145:Polyvinyls; D011687:Purines; D013450:Sulfones; D013488:Suppositories; D013607:Tablets; D014280:Triglycerides; C009683:witepsol; C016438:ethylenevinylacetate copolymer; C050528:Eudragit RS; D000068677:Sildenafil Citrate