Thymic stromal lymphopoietin: a new cytokine in asthma.
Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans. These findings suggest that interfering with the ability of cells to respond to TSLP might prevent the development of airway inflammation. Our review presents current knowledge on mediators that induce TSLP production and on the actions of TSLP on different populations of cells that are related to airway inflammation. TSLP affects dendritic cells, T cells, NKT cells, and mast cells, indicative of the broad role of TSLP in the regulation of inflammatory/allergic processes.
Rochman
Yrina
Y
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institute of Health, Building 10, Room 7B05, Bethesda, MD 20892, USA.
Leonard
Warren J
WJ
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000209:etiology*; D016207:Cytokines / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D018121:Receptors, Cytokine / Q000502:physiology; D015398:Signal Transduction; D000094632:Thymic Stromal Lymphopoietin
C498762:CRLF2 protein, human; D016207:Cytokines; D018121:Receptors, Cytokine; D000094632:Thymic Stromal Lymphopoietin