LNA functionalized gold nanoparticles as probes for double stranded DNA through triplex formation.
Nanoparticle modified LNA probes have been used for colorimetric identification of double stranded DNA via parallel triplex formation, eliminating the need for prior denaturation of the target duplex.
McKenzie
Fiona
F
Centre for Molecular Nanometrology, WestCHEM, Glasgow, UK.
Faulds
Karen
K
Graham
Duncan
D
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D015342:DNA Probes / Q000737:chemistry* / Q000235:genetics; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D019001:Nitric Oxide Synthase / Q000235:genetics; D009841:Oligonucleotides / Q000737:chemistry*
D015342:DNA Probes; D009841:Oligonucleotides; C477371:locked nucleic acid; C051802:triplex DNA; D006046:Gold; D004247:DNA; D019001:Nitric Oxide Synthase