Open chromatin and hypertranscription in embryonic stem cells.
In this issue of Cell Stem Cell, Efroni et al. (2008) use tiling microarrays to reveal genome-wide hypertranscription in mouse embryonic stem cells (ESCs), including expression of normally silent, noncoding regions. Hypertranscription may reflect the unusual "open" structure of ESC chromatin.
Turner
Bryan M
BM
Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK. b.m.turner@bham.ac.uk
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D021901:DNA, Intergenic; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D021901:DNA, Intergenic