title: Biological performance of boron-modified bioactive glass particles implanted in rat tibia bone marrow.
abstract: The aim of the present study was to characterize the neoformed bone tissue around boron-modified bioactive glass particles implanted in rat tibia bone marrow by histologic, histomorphometric and microchemical evaluation. Melt-derived glasses were prepared from a base 45S5 bioactive glass of nominal composition (45% SiO(2), 24.5% CaO, 24.5% Na(2)O and 6% P(2)O(5) in wt%). The glass composition was modified by adding 2% wt of boron oxide (45S5.2B). Histological and histomorphometric analyses using undecalcified sections showed that at 15 days post-implantation the area of neoformed bone tissue around the 45S5.2B particles was significantly higher than control 45S5 glass. No statistically significant differences were observed at 30 days post-implantation. The thickness of osseointegrated tissue on 45S5.2B BG particles was significantly greater than on the control at all experimental time-points evaluated. A statistically significant increase in the Ca:P ratio was observed in the neoformed bone around 45S5.2B particles 15 days post-implantation. The results of the present study provide evidence that particles of boron-modified 45S5 BG (45S5.2B) enhance bone formation more than 45S5 glass when implanted into the intramedullary canal of rat tibiae.
authors.affiliation: Research Laboratory, National Atomic Energy Commission (CNEA-Regional Noroeste), Salta, A4408FTV, Argentina. alegorustov@ciudad.com.ar
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Gorustovich
authors.forename: José M Porto
authors.initials: JM
authors.lastname: López
authors.forename: María B
authors.initials: MB
authors.lastname: Guglielmotti
authors.forename: Rómulo L
authors.initials: RL
authors.lastname: Cabrini
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology* / Q000502:physiology* / Q000601:surgery; D018786:Bone Substitutes / Q000008:administration & dosage* / Q000737:chemistry*; D001895:Boron / Q000008:administration & dosage* / Q000737:chemistry; D022081:Cell Surface Extensions; D002516:Ceramics; D005898:Glass / Q000737:chemistry*; D020007:Implants, Experimental; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018786:Bone Substitutes; C425330:bioactive glass 45S5; D001895:Boron