[Cholestasis in infants: a study of the Children's Hospital of Tunisia].
BACKGROUND
Cholestasis in infant constitutes an heterogeneous group of disease; diagnosis and management are often difficult. THE AIM of the study is to describe clinical, paraclinical characteristics and outcome of infants hospitalized for cholestasis in children's Hospital of Tunis.


METHODS
A retrospective study of 94 infants with cholestasis was conducted. Patients were hospitalized in four departments of paediatrics of our hospital between January 1995 and December 2005. Cholestasis complicating severe sepsis and visceral leishmaniasis were excluded.


RESULTS
Incidence of cholestasis was 8.5 cases/year which represented 0.72% of the hospitalizations. Sex ratio was 1.08 and mean age at diagnosis was 105 days (extremes: 1 day- 24 months). Biliary atresia was the most common cause of extra hepatic cholestasis (13.8%). Normal A GT cholestasis (11.7 %), benign neonatal cholestasis (11.7%) and bile duct hypoplasia (9.5%) represented the most common aetiologies of intra hepatic cholestasis. Aetiology remained unknown in 12.7% of cases. Only three infants with biliary atresia had Kasaï operation. After a mean follow-up of 6 years, 18% of patients had portal hypertension, 14.8% had hepatic failure and mortality rate was 14.8%.


CONCLUSIONS
Cholestasis of unknown aetiologies are frequent in our hospital. Poor prognosis, in our study, is due to delay to diagnosis and difficulties in medical and surgical management.
Bouyahia
Olfa
O
Hôpital d'Enfants, Bab Saadoun, Tunis, Tunisie.
Khelifi
Ibtissem
I
Mazigh
Sonia Mrad
SM
Gharsallah
Lamia
L
Chaouachi
Beji
B
Hamzaoui
Mourad
M
Barsaoui
Sihem
S
Ben Becher
Sayda
S
Bousnina
Souad
S
Boukthir
Samir
S
El Gharbi
Azza Sammoud
AS
D002779:Cholestasis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D014416:Tunisia / Q000453:epidemiology