Structural basis for HLA-A2 supertypes.
The human leukocyte antigen (HLA) alleles are extremely polymorphic among ethnic population, and the peptide-binding specificity varies for different alleles in a combinatorial manner. However, it has been suggested that majority of alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides, yet exhibiting distinct repertoires. Nonetheless, the structural basis for HLA supertype-like function is not clearly known. Here, we use structural data to explain the molecular basis for HLA-A2 supertypes.
Kangueane
Pandjassarame
P
School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
Sakharkar
Meena Kishore
MK
D000483:Alleles; D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D019295:Computational Biology; D005805:Genes, MHC Class I; D015789:HLA-A2 Antigen / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D006801:Humans; D007125:Immunogenetics
D015789:HLA-A2 Antigen