title: Breast cancer expression of E-cadherin does not differ between patients with positive and negative oncological history.
abstract: OBJECTIVE
  The question of whether or not non-sporadic breast malignancies have different immunohistochemical features than sporadic malignancies has not been investigated previously. Consequently, the purpose of this study was to compare the expression of E-cadherin (EC) in breast cancer patients with positive and negative oncologic histories.
  
  
  METHODS
  The study included 98 breast cancer patients divided into two groups: 1) without the personal or familial history of previous malignancies, and 2) with the personal history of previous malignancies and/or with the data on cancer episodes in first- and/or second-degree relatives.
  
  
  RESULTS
  There were no significant differences in the expression of EC between breast malignancies of the two groups. Moreover, statistical relationships were not observed between the positive or negative oncologic history, the age, and the menopausal status of patients, or histological tumor grade.
  
  
  CONCLUSIONS
  Although the results of our series revealed no significant differences in the expression of EC between assumed sporadic and assumed non-sporadic malignancies, there is a need for further comparative studies on the immunohistochemistry of both the breast carcinoma types in order to find the other biological markers that could suggest or exclude cancer susceptibility in a given patient. Nevertheless, the results of our study suggest that EC immunohistochemistry cannot be used as a surrogate marker for screening for hereditary breast cancer.
authors.affiliation: Department of Hygiene, Medical University of Wroclaw, and Internal Disease Clinic, 4th Military Academic Hospital, Wroclaw, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Bruzewicz
authors.forename: R
authors.initials: R
authors.lastname: Matkowski
authors.forename: G
authors.initials: G
authors.lastname: Swiatoniowski
authors.forename: E
authors.initials: E
authors.lastname: Suder
authors.forename: M
authors.initials: M
authors.lastname: Setta
authors.forename: A
authors.initials: A
authors.lastname: Połozowski
authors.forename: K
authors.initials: K
authors.lastname: Zychowicz
authors.forename: B
authors.initials: B
authors.lastname: Szynglarewicz
authors.forename: J
authors.initials: J
authors.lastname: Kornafel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D015820:Cadherins