[Evaluation of the effects of antituberculous drugs on the cytochemical status of lymphocytes in vitro].
The effects of basic drugs of chemotherapy for tuberclosis, such as isoniazid and rifampicin, on the activity of the most important mitochondrial enzymes of lymphocytic energy metabolism were studied in patients with infiltrative tuberculosis and healthy donors. The authors detected the significantly inhibited activity of succinate dehydrogenase and the redistribution of lymphocytic populations with the increased proportion of cells with the low and high activities of the enzyme. The more significant negative effect on the lymphocytes of patients with tuberculosis was observed when rifampicin was administered. In patients with pulmonary tuberculosis, the suppressed enzymatic activity of peripheral blood lymphocytes was shown to be more pronounced when the cells were incubated with rifampicin and isoniazid for 2 hours than for 1 hour.
Vasil'eva
O A
OA
Urazova
O I
OI
Serebriakova
V A
VA
Novitskiĭ
V V
VV
Strelis
A K
AK
Shevtsova
N M
NM
Voronkova
O V
OV
Mel'nik
M I
MI
Khasanova
R R
RR
D000995:Antitubercular Agents / Q000494:pharmacology*; D006651:Histocytochemistry; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism*
D000995:Antitubercular Agents; D013385:Succinate Dehydrogenase