title: Staged laparoscopic adjuvant intraperitoneal chemohyperthermia after complete resection for locally advanced colorectal or gastric cancer: a preliminary experience.
abstract: BACKGROUND
  Cytoreductive surgery followed by intraperitoneal chemohyperthermia (IPCH) is a promising treatment for patients with peritoneal carcinomatosis, a disease with dismal prognosis.
  
  
  METHODS
  We describe our preliminary experience with staged adjuvant laparoscopic IPCH after complete resection in patients with locally or regionally advanced colorectal or gastric cancer.
  
  
  RESULTS
  Twenty-one patients underwent resection for colorectal (N = 16) or gastric cancer (N = 5) followed by staged laparoscopic IPCH. No conversion to laparotomy was required. No major operative incident occurred. Mean duration of hospital stay was 12 days (range 9-23 days). No mortality occurred in the 30-day postoperative period. Four patients developed major complications (19%). One patient (5%) was reoperated. Mean follow-up period was 15.5 months (range 9-29 months). Three patients died, including two of cancer-related causes. No patient developed peritoneal carcinomatosis during the follow-up period.
  
  
  CONCLUSIONS
  Staged laparoscopic adjuvant IPCH after open or laparoscopic resection in selected patients with colorectal or gastric cancer is feasible and reasonably safe. However, additional data are required to determine the effect on long-term survival.
authors.affiliation: Department of General and Minimally Invasive Surgery, Centre Hospitalier Intercommunal (Poissy Medical Center), 10, rue de Champ Gaillard, 78303 Poissy Cedex, France. chouillard@yahoo.com
authors.forename: Elie
authors.initials: E
authors.lastname: Chouillard
authors.forename: Toufic
authors.initials: T
authors.lastname: Ata
authors.forename: Bernard
authors.initials: B
authors.lastname: De Jonghe
authors.forename: Léon
authors.initials: L
authors.lastname: Maggiori
authors.forename: Nada
authors.initials: N
authors.lastname: Helmy
authors.forename: Yvan
authors.initials: Y
authors.lastname: Coscas
authors.forename: Hervé
authors.initials: H
authors.lastname: Outin
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010865:Pilot Projects; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016685:Mitomycin; D002945:Cisplatin