Analyses of cell growth in tissue-engineering scaffolds.
Cell growth is critical to the regeneration of most tissues. Current methods for analyzing cell growth in scaffolds used for tissue engineering are reviewed in the context of their limitations. A mathematical model for analyzing cell growth in scaffolds is presented to highlight the key parameters that govern cell growth. To overcome the diffusion barrier that limits the formation of thicker tissues, strategies to promote better nutrient delivery are discussed.
Dunn
James Cy
JC
Mail Code 709818, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. jdunn@mednet.ucla.edu
D000818:Animals; D021522:Bioartificial Organs; D001672:Biocompatible Materials / Q000737:chemistry; D032701:Biomimetics; D049109:Cell Proliferation; D004058:Diffusion; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
D001672:Biocompatible Materials; D011108:Polymers; D010100:Oxygen