Study on the preparation of collagen-modified silk fibroin films and their properties.
Blended films were prepared from a silk fibroin (SF) solution by adding a small amount of type I collagen (<5%). The mechanical properties of the wet films modified by collagen were improved obviously. The elongation at break reached 42%, and the smaller contact angles revealed that modified films had better hydrophilicity. 1% heparin was also added to modify the SF films to further improve the in vitro antithrombogenecity. The internal structure of the modified SF films was investigated with scanning electron microscopy, x-ray diffraction and Fourier transform infrared attenuated total reflection spectroscopy. The result indicates that the addition of a small amount of collagen and heparin did not change their conformation.
Tang
Yin
Y
Research Center of Material Science, Beijing Institute of Technology, Bejing 100081, People's Republic of China.
Cao
Chuanbao
C
Ma
Xilan
X
Chen
Chen
C
Zhu
Hesun
H
D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry*; D001777:Blood Coagulation / Q000187:drug effects*; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry*; D004548:Elasticity; D005349:Fibroins / Q000008:administration & dosage* / Q000737:chemistry*; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D047011:Silk / Q000008:administration & dosage* / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D047011:Silk; D006493:Heparin; D003094:Collagen; D005349:Fibroins