Gene transfer after subarachnoid hemorrhage: a tool and potential therapy.
This mini-review describes steps towards gene therapy to prevent vasospasm after subarachnoid hemorrhage, and summarizes some remaining obstacles. With recombinant adenoviruses, it is now possible to prevent vasospasm in experimental animals. If an adenoviral or other effective vector is demonstrated to be safe, it is likely that gene therapy will be used in patients to prevent vasospasm.
Heistad
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Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242-1081, USA. donald-heistad@uiowa.edu
Watanabe
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Y
Chu
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Y
D005786:Gene Expression Regulation; D022761:Gene Transfer, Horizontal; D006801:Humans; D013345:Subarachnoid Hemorrhage / Q000235:genetics*; D020301:Vasospasm, Intracranial / Q000235:genetics / Q000517:prevention & control*