title: A microwave-assisted and heteropolyacids-catalysed cyclocondensation reaction for the synthesis of 4(3H)-quinazolinones.
abstract: We have investigated a microwave-assisted synthesis of 4(3H)-quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H(3)PW(12)O(40).13H(2)O, H(4)SiW(12)O(40).13H(2)O,H(4)SiMo(12)O(40).13H(2)O or H(3)PMo(12)O(40).13H(2)O) as catalysts. We found that the the use of H(3)PW(12)O(40).13H(2)O acid coupled to microwave irradiation allows a solvent-free, rapid (approximately 13min) and high-yielding reaction.
authors.affiliation: Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
authors.forename: Karima
authors.initials: K
authors.lastname: Ighilahriz
authors.affiliation: Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
authors.forename: Baya
authors.initials: B
authors.lastname: Boutemeur
authors.affiliation: Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
authors.forename: Fariza
authors.initials: F
authors.lastname: Chami
authors.affiliation: Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
authors.forename: Cherifa
authors.initials: C
authors.lastname: Rabia
authors.affiliation: Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
authors.forename: Maâmar
authors.initials: M
authors.lastname: Hamdi
authors.affiliation: Laboratoire de Biochimie-Purpan, Institut Fédératif de Biologie, CHU Toulouse 330, Avenue de Grande-Bretagne - F- 31059 Toulouse cedex 9, France.
authors.forename: Safouane M
authors.initials: SM
authors.lastname: Hamdi
mesh_terms: D000143:Acids / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D008872:Microwaves; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D062367:ortho-Aminobenzoates / Q000737:chemistry
chemical_list: D000143:Acids; D000814:Aniline Compounds; D052999:Quinazolinones; D012997:Solvents; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; C023650:aniline