title: Pseudorotaxane-like supramolecular complex of coenzyme Q10 with gamma-cyclodextrin formed by solubility method.
abstract: The purpose of this study is to reveal whether Coenzyme Q10 (CoQ10) forms pseudorotaxane-like supramolecular complex with gamma-cyclodextrin (gamma-CyD). The poorly soluble complex of CoQ10 with gamma-CyD in water was prepared by the solubility method. The X-ray diffraction pattern of the CoQ10/gamma-CyD complex was different from that of the physical mixture, but almost the same as that of polypropylene glycol (PPG)/gamma-CyD polypseudorotaxane. Also, the differential scanning calorimetrical study and FT-IR study demonstrated the interaction between CoQ10 and gamma-CyD in the solid state. The 1H-NMR study and the yield study of the supramolecular complex of CoQ10 with gamma-CyD demonstrated that the stoichiometry was 5 : 1 (gamma-CyD : CoQ10). The dispersion rate of CoQ10 was markedly increased by the formation of the supramolecular complex with gamma-CyD, possibly due to submicron-ordered particle formulation. In fact, CoQ10 was found to form submicron-sized supramolecular particles with gamma-CyD, when prepared by the solubility method. Consequently, the present study showed that CoQ10 forms the pseudorotaxane-like supramolecular complex with gamma-CyD in water.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Nishimura
authors.forename: Taishi
authors.initials: T
authors.lastname: Higashi
authors.forename: Ayumi
authors.initials: A
authors.lastname: Yoshimatsu
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Hirayama
authors.forename: Kaneto
authors.initials: K
authors.lastname: Uekama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Arima
mesh_terms: D002152:Calorimetry, Differential Scanning; D009682:Magnetic Resonance Spectroscopy; D010316:Particle Size; D011208:Powders; D043862:Rotaxanes / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013535:Suspensions; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000737:chemistry; D014961:X-Ray Diffraction; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D011208:Powders; D043862:Rotaxanes; D013535:Suspensions; D047408:gamma-Cyclodextrins; D014451:Ubiquinone; C024989:coenzyme Q10