title: Molecular epidemiology of chicken anemia virus (CAV) in southeastern Chinese live birds markets.
abstract: Between January 2004 and December 2005, cloacal swabs from essentially healthy chickens and silky chickens from live birds markets in Guangdong and Hunan provinces in southeastern China were screened for chicken anemia virus (CAV) by polymerase chain reaction. Phylogenetic analysis of the major structural protein VP1 sequences showed no clear genotype cluster and no correlation with the geographic origin of CAV strains. Virus evolution at the amino acid level was very slow, which corresponds to a strong negative selection of the VP1 gene in China and worldwide. A high proportion (87%) of birds was CAV positive, suggesting that many farms in the region were infected. Further investigations are necessary to evaluate the economic losses caused by CAV and the cost-benefit of vaccination.
authors.affiliation: Institute of Immunology, Laboratoire National de Santé, 20A, rue Auguste Lumière, L-1950 Luxembourg, Grand-Duchy of Luxembourg.
authors.forename: M F
authors.initials: MF
authors.lastname: Ducatez
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Guan
authors.forename: C P
authors.initials: CP
authors.lastname: Muller
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017727:Chicken anemia virus / Q000145:classification / Q000235:genetics*; D002645:Chickens / Q000821:virology*; D002681:China / Q000453:epidemiology; D018173:Circoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D003132:Commerce; D014644:Genetic Variation; D017720:Molecular Epidemiology; D010802:Phylogeny; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology*; D012641:Selection, Genetic; D013997:Time Factors; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014764:Viral Proteins