title: CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load.
abstract: We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Andrade
authors.forename: Justin R
authors.initials: JR
authors.lastname: Bailey
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Frances H
authors.initials: FH
authors.lastname: Philp
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Quinn
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Williams
authors.forename: Stuart C
authors.initials: SC
authors.lastname: Ray
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D008212:Lymphocyte Depletion; D008297:Male; D019562:Viral Load
chemical_list: D015235:HLA-B Antigens; C500126:HLA-B*58:01 antigen; C103707:HLA-B57 antigen