title: Pattern of macular thickness changes measured by ocular coherence tomography in patients with multiple sclerosis.
abstract: BACKGROUND
  An analysis of the pattern of retinal thickness changes in macula in patients with multiple sclerosis (MS) was performed.
  
  
  METHODS
  In fifteen patients with MS retinal thickness measurements in the central (fovea plus inner macular ring) and peripheral (outer ring) macula obtained by ocular coherence tomography (OCT-3 device) were compared to those of 15 age-matched healthy controls.
  
  
  RESULTS
  Eyes of MS patients had on the average a thinner macula (241.8 +/- 20.6 micrometers) than control eyes (252.0 +/- 16.4, p value 0.038). Significant segmental differences occurred in the central macula (p = 0.013). Eight eyes with a positive history of optic neuritis (ON) had on average a thinner macula (226.8 +/- 14.0) than eyes of MS patients without a history of ON (non-ON eyes: 247.3 +/- 20.1, p value 0.01). The only measure significantly different between non-ON and control eyes was the ratio between the central and peripheral macular thickness (p = 0.017). Average macular thickness in non-ON eyes, unlike control eyes (r = - 0.63, p = 0.0002), did not correlate with age (r = 0.01, p = 0.97), however, it did show a borderline correlation with disease duration (r = - 0.41, p = 0.056).
  
  
  CONCLUSIONS
  Preferential thinning in the central relative to the peripheral macular region is present in eyes of patients with MS. The macular thickness pattern is likely due to the histological distribution of nerve fibre layer and retinal ganglion cell in the macular area and seems to be particularly informative of neurodegeneration in the eyes of MS patients without a history of optic neuritis.
authors.affiliation: Outpatient Neurology Clinic, University Hospital Basel, Basel, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Gugleta
authors.forename: M
authors.initials: M
authors.lastname: Mehling
authors.forename: A
authors.initials: A
authors.lastname: Kochkorov
authors.forename: M
authors.initials: M
authors.lastname: Grieshaber
authors.forename: R
authors.initials: R
authors.lastname: Katamay
authors.forename: J
authors.initials: J
authors.lastname: Flammer
authors.forename: S
authors.initials: S
authors.lastname: Orgül
authors.forename: L
authors.initials: L
authors.lastname: Kappos
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008268:Macular Degeneration / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*