title: Regional variations of low-density lipoprotein oxidizability in hemodialysis patients may explain discrepancies in interventional therapy on oxidative profile.
abstract: OBJECTIVE
  This study aimed at evaluating oxidative stress (OS) markers (i) in a cross-sectional study of hemodialysis (HD) patients to investigate potential regional effects of these markers and (ii) in a prospective crossover study to evaluate vitamin E-coated membrane (VE) effects.
  
  
  METHODS
  At baseline, OS parameters including low-density lipoprotein (LDL) oxidizability were measured in HD patients from five dialysis facilities. Patients were then randomly assigned to two treatment groups: group I patients (n = 33) switching to VE, and group II patients (n = 29) still using reference polysulfone (PS) membrane. After 3 months, patients were switched from VE to PS and vice versa for 6 months. The same OS parameters were measured after each period.
  
  
  RESULTS
  At baseline, the cross-sectional analysis of LDL oxidizability showed a regional effect. By contrast, the crossover study did not show beneficial effects of VE on this parameter.
  
  
  CONCLUSIONS
  Regional variations of LDL oxidizability in HD patients exist and may explain discrepancies in interventional therapy on OS.
authors.affiliation: Laboratoire de Biochimie, Centre Hospitalier Universitaire, Université Montpellier I, Montpellier, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Morena
authors.forename: Valérie
authors.initials: V
authors.lastname: Gausson
authors.forename: Nadya
authors.initials: N
authors.lastname: Mothu
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bouchet
authors.forename: Monique
authors.initials: M
authors.lastname: Chanas
authors.forename: Mireille
authors.initials: M
authors.lastname: Grandvuillemin
authors.forename: Alain
authors.initials: A
authors.lastname: Robert
authors.forename: Carlos
authors.initials: C
authors.lastname: Vela
authors.forename: Bernard
authors.initials: B
authors.lastname: Canaud
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Michel
authors.initials: M
authors.lastname: Olmer
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011108:Polymers; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods; D013450:Sulfones; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D008055:Lipids; D008077:Lipoproteins, LDL; D008567:Membranes, Artificial; D011108:Polymers; D017382:Reactive Oxygen Species; D013450:Sulfones; D014810:Vitamin E; C017662:polysulfone P 1700; D005978:Glutathione