Reduced energy utilization in the brain is a feature of an animal model of fatigue.
Recently, the authors established an animal model of fatigue. The fatigued animals showed reduced 2-[18F]fluoro-2-deoxy-D-glucose uptake in their brain, although their blood glucose level did not differ from that of the control animals. For further clarification, the study measured regional cerebral blood flow, ATP level, and the ability of mitochondria to produce ATP in the brain of the fatigued and control rats. The fatigued animals showed almost equal regional cerebral blood flow, a significantly higher ATP level, and almost equal mitochondria ability to produce ATP. These data suggest that decreased energy utilization in the brain is a feature of fatigue.
Tanaka
Masaaki
M
Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Watanabe
Yasuyoshi
Y
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology*; D005221:Fatigue / Q000473:pathology*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats
D019788:Fluorodeoxyglucose F18; D000255:Adenosine Triphosphate