title: Asymmetric total synthesis of (+)-phoslactomycin B.
abstract: (+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki-Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Delta12-double bond.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Setsuya
authors.initials: S
authors.lastname: Shibahara
authors.forename: Masataka
authors.initials: M
authors.lastname: Fujino
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Ishihara
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007783:Lactones; D009943:Organophosphorus Compounds; C060449:phoslactomycin B