title: Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats.
abstract: Rats were treated by gavage once daily with 2,4-dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40-47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and females of any group. A significant decrease in body weight gain and significant increase in liver weight were found in males and females at 30 mg/kg bw/day. The number of live pups on postnatal days (PNDs) 0 and 4, live birth index, and body weight of live male and female pups on PNDs 0 and 1 were significantly lowered at 30 mg/kg bw/day. External and internal examinations of pups revealed no increased incidence of malformations in DNP-treated groups. On the basis of these findings, we concluded that DNP has general and reproductive/developmental toxicity, but not teratogenicity, under the present conditions. The NOAEL of DNP is considered to be 10 mg/kg bw/day in rats.
authors.affiliation: Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo 158-8501, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masao
authors.initials: M
authors.lastname: Sunaga
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Hirata-Koizumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hirose
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kamata
authors.forename: Makoto
authors.initials: M
authors.lastname: Ema
mesh_terms: D019297:2,4-Dinitrophenol / Q000633:toxicity*; D000014:Abnormalities, Drug-Induced; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight; D005260:Female; D008099:Liver / Q000002:abnormalities / Q000187:drug effects; D008297:Male; D009929:Organ Size; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*
chemical_list: D019297:2,4-Dinitrophenol