Utility of serum cystatin C as a clinical measure of renal function in dogs.
A human kit for cystatin C determination was evaluated for use with canine sera. A reference range was also established. The association between cystatin C and glomerular filtration rate (GFR) was evaluated in 60 dogs with various diseases, by using exogenous creatinine plasma clearance (ECPC) as a measure of GFR. The correlation between cystatin C and ECPC (correlation coefficient [r] = -0.630; P<0.001) was stronger than the correlation between serum creatinine and ECPC (r = -0.572; P<0.001). Nonrenal diseases (e.g., neoplasia, infection) did not influence serum cystatin C concentration. Test sensitivity was significantly better (P<0.001) for cystatin C (76%) than for creatinine (65%). Specificities for the two tests were 87% and 91%, respectively.
Wehner
Astrid
A
Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Munich, Germany 80539.
Hartmann
Katrin
K
Hirschberger
Johannes
J
D000818:Animals; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D007677:Kidney Function Tests / Q000592:standards / Q000662:veterinary; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000592:standards / Q000662:veterinary; D012372:ROC Curve; D011933:Reagent Kits, Diagnostic / Q000592:standards / Q000662:veterinary; D012016:Reference Values; D012680:Sensitivity and Specificity
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D011933:Reagent Kits, Diagnostic; D003404:Creatinine