Remifentanil in obstetrics.
OBJECTIVE
The present study summarizes the knowledge to date of the use of remifentanil in obstetric anaesthesia and analgesia.


RESULTS
Modest labour analgesia, particularly for the first stage, can be achieved using a patient-controlled analgesia bolus of 40 microg with a 2-min lockout. Neonatal effects are minimal; however, maternal desaturation is a possibility and requires one-to-one supervision and appropriate monitoring. Background infusions can improve analgesia, but maternal desaturation or even apnoea is more likely. Remifentanil is effective at obtunding responses to airway manipulation and surgery under general anaesthesia. Neonatal effects are more pronounced and 50% of neonates may need assisted ventilation, and occasionally naloxone.


CONCLUSIONS
Remifentanil has a place in obstetric anaesthesia and analgesia. Further studies are needed to confirm if background infusions are safe in addition to patient-controlled analgesia. Studies are needed to establish a dose range under general anaesthesia that prevents neonatal respiratory depression at birth.
Hill
David
D
Department of Anaesthesia, Ulster Hospital, Belfast, UK. davidhill@doctors.org.uk
D016362:Analgesia, Obstetrical / Q000379:methods*; D016058:Analgesia, Patient-Controlled / Q000379:methods*; D000767:Anesthesia, Epidural; D000768:Anesthesia, General / Q000379:methods*; D018686:Anesthetics, Intravenous; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000032:analysis; D010880:Piperidines; D011247:Pregnancy; D000077208:Remifentanil; D012131:Respiratory Insufficiency / Q000517:prevention & control; D016896:Treatment Outcome
D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D010100:Oxygen