title: Triphenyltin ortho-aminophenyl- and 2-pyridyl-thiolates: synthesis and in vitro antitumour activity.
abstract: The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) A), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin.
authors.affiliation: Free University of Brussels V.U.B., Pleinlaan 2 Department of General and Organic Chemistry Faculty of Applied Sciences Brussels B-1050 Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Gielen
authors.forename: A
authors.initials: A
authors.lastname: Bouhdid
authors.forename: E R
authors.initials: ER
authors.lastname: Tiekink
authors.forename: D
authors.initials: D
authors.lastname: de Vos
authors.forename: R
authors.initials: R
authors.lastname: Willem