title: Patterns of combined prescriptions of aspirin-Ginkgo biloba in Taiwan: a population-based study.
abstract: OBJECTIVE
  Although interactions between aspirin and Ginkgo biloba extract (GBE) have been documented, the extent to which these two drugs are used in combination remains unclear. The aim of this study was to estimate the extent and utilization patterns of combined prescriptions of aspirin and GBE in Taiwan based on an analysis of a nationwide database.
  
  
  METHODS
  A representative nationwide sample of 200 000 National Health Insurance (NHI) beneficiaries in Taiwan was used. The prescription details of ambulatory care claims for this sample of beneficiaries for the period 1997-2003 were analysed. The prevalence of aspirin and GBE prescriptions was evaluated. The extent of co-prescription of the two drugs was assessed together with the associated patient characteristics.
  
  
  RESULTS
  There was an increase in the number of aspirin prescriptions (from 29 986 out of 2 454 879 (1.2%) in 1997, to 50 614 out of 2 499 605 (2.0%) in 2003). Aspirin was mostly prescribed to patients over 50 years old. The percentage of prescriptions with aspirin increased rapidly from 57% to 84%, among those over 50 years old. The number of prescriptions with GBE also increased from 3039 to 6171 and 78-84% was prescribed to those 50 years or older. During the study period, combined prescriptions of aspirin and GBE dramatically increased four times. Most prescriptions were longer than 14 days and 42.4% of combined prescriptions were found to be at the same ambulatory care visit.
  
  
  CONCLUSIONS
  The findings of this study suggest that there is an increasing trend in co-prescription of aspirin and GBE for Taiwan's elderly population during 1997-2003. This trend is of concern and worthy of note.
authors.affiliation: Institute of Traditional Medicine, School of Medicine, National Yang Ming University, and Committee on Chinese Medicine and Pharmacy, Department of Health, Executive Yuan, Taipei, Taiwan.
authors.forename: L-C
authors.initials: LC
authors.lastname: Chang
authors.forename: N
authors.initials: N
authors.lastname: Huang
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Chou
authors.forename: F-Y
authors.initials: FY
authors.lastname: Kao
authors.forename: P-C
authors.initials: PC
authors.lastname: Hsieh
authors.forename: Y-T
authors.initials: YT
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage*; D016208:Databases, Factual; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005260:Female; D020441:Ginkgo biloba; D006801:Humans; D008297:Male; D008875:Middle Aged; D009313:National Health Programs; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D013624:Taiwan
chemical_list: D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin