title: ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.
abstract: ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of 'complex functions'. A 'Complex function' is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.
authors.affiliation: Helmholtz Zentrum Munich, National Research Center for Environment and Health, Institute for Bioinformatics, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Antonov
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schmidt
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Hans W
authors.initials: HW
authors.lastname: Mewes
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D005796:Genes / Q000502:physiology*; D006801:Humans; D020407:Internet; D051379:Mice; D011817:Rabbits; D012984:Software