[Bile duct involvement in autoimmune pancreatitis: classification and treatment].
Autoimmune pancreatitis is a rare disease characterized by inflammation of the pancreatic parenchyma, irregular narrowing of the pancreatic duct, periductal lymphoplasmacytic infiltration and fibrosis at histological examination, the presence of autoantibodies and hypergammaglobulinemia, as well as the possible association of cholangitis and other autoimmune diseases. There is a favorable response to steroid therapy. We report the case of a patient with autoimmune pancreatitis with bile duct involvement and peripheral eosinophilia, requiring long-term immunosuppressant treatment. The diagnosis of a diffuse form of AIP was made without direct histological evidence and based on indirect imaging, clinical and laboratory findings in an autoimmune context. The histological and imaging studies of bile duct involvement and the favourable response to steroids were additional arguments.
Gincoul
R
R
Service d'hépatogastroentérologie, pavillon H, hôpital Edouard-Herriot, Lyon cedex 03, France. rodica_h13@yahoo.fr
Pujol
B
B
Dumortier
J
J
Scoazec
J-Y
JY
Hervieu
V
V
Crombe-Ternamian
A
A
Pilleul
F
F
Napoléon
B
B
Ponchon
T
T
D001327:Autoimmune Diseases / Q000150:complications*; D001649:Bile Duct Diseases / Q000145:classification / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D010195:Pancreatitis / Q000150:complications*