title: Synthesis of new N-arylpyrimidin-2-amine derivatives using a palladium catalyst.
abstract: New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesized from the corresponding amines, applying optimized Buchwald-Hartwig amination conditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxide in refluxing toluene under a nitrogen atmosphere. The target N-aryl derivatives were obtained in moderate to good yields ranging from 27% to 82%. The procedure described could be widely employed for the preparation of new heterocyclic compounds. The structures of the new compounds were confirmed by FT-NMR, FT-IR and elemental analysis.
authors.affiliation: Department of Biomolecular Science, University of Science and Technology, Daejon, Korea. dr_i_eldeeb_2003@yahoo.com
authors.forename: Ibrahim Mustafa
authors.initials: IM
authors.lastname: El-Deeb
authors.forename: Jae Chun
authors.initials: JC
authors.lastname: Ryu
authors.forename: So Ha
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D011743:Pyrimidines; D010165:Palladium