Estimate of infant HIV-free survival at 6 to 8 weeks of age due to maternal antiretroviral prophylaxis in Sub-Saharan Africa, 2004-2005.
The objective of this study is to estimate the number of infants alive and HIV-free at 6 to 8 weeks in sub-Saharan Africa due to intervention with antiretroviral prophylaxis to prevent mother-to-child transmission. The number of additional uninfected live infants at 6 to 8 weeks of age due to prophylaxis was calculated using prevalence and prophylaxis data from the World Health Organization and United Nations Children's Fund and data on the efficacy of nevirapine and birth and mortality rates among infants of infected mothers who received prophylaxis in sub-Saharan Africa. Approximately 31 474 African infants were spared from HIV infection or death by 6 to 8 weeks of age due to prophylaxis in 2004 and 2005. The number of infections and deaths averted per year increased from 13 710 in 2004 to 17 764 in 2005. The estimated number of infant HIV infections and deaths averted in 2004 and 2005 due to prophylaxis is encouraging.
Boeke
Caroline E
CE
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Jackson
J Brooks
JB
D017954:Africa South of the Sahara / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality* / Q000635:transmission; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D019829:Nevirapine / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control* / Q000821:virology; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D015996:Survival Rate; D014480:United Nations; D014944:World Health Organization
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine