title: Contact lens-associated fusarium keratitis in Switzerland.
abstract: BACKGROUND
  Fusarium has been an exceptionally rare cause of infectious keratitis. A recent outbreak of Fusarium keratitis in contact lens wearers in North America and Asia has been associated with the multipurpose disinfection solution ReNu with MoistureLoc (Bausch&Lomb). We report a series of Fusarium keratitis in Swiss contact lens wearers.
  
  
  METHODS
  A multicentre retrospective case review of patients with corneal ulceration and a positive microbiological identification of Fusarium species was undertaken.
  
  
  RESULTS
  Between September 2005 and August 2007, six cases of Fusarium keratitis were identified. Patients were 39 to 63 years of age. All patients were using disposable soft contact lenses for at least two years. Four patients used daily wear disposable lenses. Two patients were wearing 1-monthly disposable lenses and used ReNu with MoistureLoc solution. Due to multiresistant Fusarium, enucleation was required in two cases and an emergency keratoplasty was performed in three cases. An optical keratoplasty was undertaken in one case that developed corneal scarring. Final visual acuity in patients with preserved eyes ranged from light perception to 8 / 20.
  
  
  CONCLUSIONS
  Exposure to ReNu with MoistureLoc is not the only risk factor for Fusarium keratitis. In addition to antifungal therapy, an early keratoplasty with excision of the infected tissue seems mandatory to improve prognosis.
authors.affiliation: Department of Ophthalmology, University of Zurich, Zurich, Switzerland. claude.kaufmann2@usz.ch
authors.forename: C
authors.initials: C
authors.lastname: Kaufmann
authors.forename: B E
authors.initials: BE
authors.lastname: Frueh
authors.forename: J
authors.initials: J
authors.lastname: Messerli
authors.forename: W
authors.initials: W
authors.lastname: Bernauer
authors.forename: M A
authors.initials: MA
authors.lastname: Thiel
mesh_terms: D000328:Adult; D018639:Contact Lens Solutions / Q000009:adverse effects*; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013557:Switzerland
chemical_list: D018639:Contact Lens Solutions