Cabergoline and the risk of valvular lesions in endocrine disease.
OBJECTIVE
The cardiac valvular risk associated with lower exposure to cabergoline in common endocrine conditions such as hyperprolactinemia is unknown.


RESULTS
We performed a cross-sectional, case-control echocardiographic study to assess the valvular status in 102 subjects receiving cabergoline for endocrine disorders and 51 matched control subjects. Cabergoline treatment ranged from 12 to 228 months, with a cumulative dose of 18-1718 mg. Valvular regurgitation was equally prevalent in both groups and was almost exclusively mild. Two cabergoline-treated subjects had moderate mitral regurgitation; there was no relationship between cabergoline dose and the presence or severity of mitral valve regurgitation (P=NS). Mitral valve tenting area was significantly greater in the cabergoline group when compared with the control subjects (P=0.03). Mitral valve leaflet thickening was observed in 5.9% of cabergoline-treated subjects; no relationship with the cumulative cabergoline dose was found. No patient had aortic or tricuspid valvular restriction.


CONCLUSIONS
No significantly increased risk of clinically relevant cardiac valve disorders was found in subjects treated with long-term cabergoline therapy at the doses used in endocrine practice. While exposure to cabergoline appears to be safe during low-dose long-term therapy, an association with subclinical changes in mitral valve geometry cannot be completely excluded.
Lancellotti
Patrizio
P
Department of Cardiology, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart-Tilman, University of Liège, B-4000 Liège, Belgium.
Livadariu
Elena
E
Markov
Muriel
M
Daly
Adrian F
AF
Burlacu
Maria-Cristina
MC
Betea
Daniela
D
Pierard
Luc
L
Beckers
Albert
A
D000328:Adult; D000368:Aged; D000077465:Cabergoline; D003430:Cross-Sectional Studies; D018491:Dopamine Agonists / Q000009:adverse effects / Q000627:therapeutic use; D004452:Echocardiography; D004700:Endocrine System Diseases / Q000188:drug therapy*; D004873:Ergolines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000187:drug effects / Q000473:pathology; D008944:Mitral Valve Insufficiency / Q000139:chemically induced / Q000473:pathology; D012307:Risk Factors
D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline