title: Infectious complications after chemotherapy and stem cell transplantation in multiple myeloma: implications of Fc gamma receptor and myeloperoxidase promoter polymorphisms.
abstract: Multiple myeloma is associated with a high risk of infections. We hypothesized that Fc gamma receptor (FCGR) and myeloperoxidase (MPO) promoter gene polymorphisms influence the risk of infections after induction chemotherapy (IC) and autologous stem cell transplantation (ASCT). Retrospectively, we analysed 136 patient courses of IC and 113 procedures of ASCT. Genetic analyses were made with PCR techniques on genomic DNA. The incidence rate ratio of sepsis during ASCT in patients homozygous for the G-129MPO promoter type was 0.30 (95% CI: 0.09-0.96). The G-463AMPO promoter polymorphism was not associated with the risk of infections. The polymorphisms of FCGR2A, FCGR3A and FCGR3B were not convincingly associated with infections. The NA1 variant of FCGR3B was strongly skewed with other risk factors, and the results in IC and ASCT were conflicting. Further studies of the G-129AMPO promoter as a potential risk modifier for infections are relevant.
authors.affiliation: Department of Hematology, University Hospital of Aarhus, THG, Aarhus, DK-8000, Denmark. rlg05im@as.aaa.dk
authors.forename: Ingolf
authors.initials: I
authors.lastname: Mølle
authors.forename: Mette
authors.initials: M
authors.lastname: Ostergaard
authors.forename: Dorte
authors.initials: D
authors.lastname: Melsvik
authors.forename: Charlotte Guldborg
authors.initials: CG
authors.lastname: Nyvold
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D058851:GPI-Linked Proteins; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000628:therapy*; D009195:Peroxidase / Q000235:genetics*; D011014:Pneumonia / Q000209:etiology / Q000473:pathology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D017452:Receptors, IgG / Q000235:genetics*; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology* / Q000473:pathology; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous
chemical_list: D000970:Antineoplastic Agents; C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D017452:Receptors, IgG; D009195:Peroxidase