Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia.
Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter-defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward.
Wilde
Arthur A M
AA
University of Amsterdam, Amsterdam. a.a.wilde@amc.uva.nl
Bhuiyan
Zahurul A
ZA
Crotti
Lia
L
Facchini
Mario
M
De Ferrari
Gaetano M
GM
Paul
Thomas
T
Ferrandi
Chiara
C
Koolbergen
Dave R
DR
Odero
Attilio
A
Schwartz
Peter J
PJ
D000293:Adolescent; D002395:Catecholamines; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000294:innervation*; D006801:Humans; D008297:Male; D013562:Sympathectomy; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy
D002395:Catecholamines