[Modulating effects of protein kinase A on intracellular signal systems in the course of skin wound healing in patients with diabetes mellitus].
The purpose of this study was to examine the modulating effects of protein kinase A (PKA) on the performance of signal systems triggered while activating alpha2-adrenoceptors and eNOS in the course of a wound process in patients with type 2 diabetes mellitus. Patients with the diabetic foot were shown to have impaired adrenergic responsiveness, accompanied by reduced eNOS activity and PKA inhibition. The positive therapeutic effect was noted with the increased stimulating effect of the PKA system on PKG on days 3 to 5 and on eNOS on days 10-14 of therapy. The preserving eNOS activity deficit was compensated for by the PKA-induced increase in PKG stimulation. The modulating effects of PKA are a compensatory intracellular mechanism of adaptation when NO production is decreased, which may be used to develop new therapeutic corrections of the dysregeneratory syndrome.
Barinova
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D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology* / Q000628:therapy; D017719:Diabetic Foot / Q000201:enzymology* / Q000628:therapy; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000201:enzymology*; D014945:Wound Healing
D011941:Receptors, Adrenergic; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D017868:Cyclic AMP-Dependent Protein Kinases; D017869:Cyclic GMP-Dependent Protein Kinases