title: Receptor for advanced glycation end product expression in experimental diabetic retinopathy.
abstract: The advanced glycation end product (AGE)-receptor for AGE (RAGE) pathway is involved in the pathogenesis of diabetic microvascular damage. The special distribution of RAGE and its engagement has an impact on the development of diabetic retinopathy. In the present study, we used immunofluorescence and confocal laser microscopy to study RAGE expression with special emphasis on Müller glia in Sprague Dawley rats. RAGE expression was low in nondiabetic retinae and was found in ganglion cells and Müller cell end feet. In diabetic retinae, upregulated RAGE was predominantly expressed in retinal glia. Since Müller cells are important in the regulation of important features of early retinal vascular damage, such as vascular permeability, homeostasis, and response to stress, RAGE appears to be a central modulator in diabetic retinopathy.
authors.affiliation: 5th Medical Clinic, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Wang
authors.forename: Franziska
authors.initials: F
authors.lastname: Vom Hagen
authors.forename: Frederick
authors.initials: F
authors.lastname: Pfister
authors.forename: Angelika
authors.initials: A
authors.lastname: Bierhaus
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Feng
authors.forename: Reinhold
authors.initials: R
authors.lastname: Gans
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hammes
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D012016:Reference Values; D012160:Retina / Q000378:metabolism / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic