title: Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB.
abstract: The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression.
authors.affiliation: Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences. kevsan@orc.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Kalinina
authors.forename: N N
authors.initials: NN
authors.lastname: Chernov
authors.forename: A N
authors.initials: AN
authors.lastname: Saprin
authors.forename: Y N
authors.initials: YN
authors.lastname: Kotova
authors.forename: Y A
authors.initials: YA
authors.lastname: Gavrilova
authors.forename: N S
authors.initials: NS
authors.lastname: Chermnykh
authors.forename: N P
authors.initials: NP
authors.lastname: Shcherbak
mesh_terms: D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics*; D013879:Thioredoxins / Q000235:genetics* / Q000378:metabolism
chemical_list: D007527:Isoenzymes; D013879:Thioredoxins