title: A novel five-way chromosomal translocation observed in chronic myelogenous leukemia.
abstract: Most patients with chronic myelogenous leukemia (CML) show a Philadelphia (Ph) chromosome with a characteristic translocation between chromosomes 9 and 22. However, there are variant complex translocations involving other chromosomes in addition to the standard translocation. We describe a case of CML showing a complex and novel chromosomal translocation involving five chromosomes, t(4;12;7;9;22).
authors.affiliation: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, Japan 078-8510. ikuta@asahikawa-med.ac.jp
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ikuta
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Torimoto
authors.forename: Junko
authors.initials: J
authors.lastname: Jimbo
authors.forename: Junki
authors.initials: J
authors.lastname: Inamura
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hosoki
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shindo
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kohgo
mesh_terms: D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002894:Chromosomes, Human, Pair 4; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008954:Models, Biological; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic