title: Brain MRI abnormalities in ataxia-telangiectasia.
abstract: BACKGROUND
  Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder, initially characterized by normal brain magnetic resonance imaging (MRI).
  
  
  METHODS
  In a 34-year-old woman patient with AT, MRI revealed extensive and diffuse white matter dismyelination, T1 and T2 hypointense lesions, T1 hypointense but T2 hyperintense lesions, and numerous dilated telangiectases upon gadolinium enhancement.
  
  
  CONCLUSIONS
  In our patient, brain MRI confirmed extensive extracerebellar lesions in AT.
  
  
  CONCLUSIONS
  Our report broadens the spectrum of brain MRI abnormalities in AT and supports the hypothesis on cerebrovascular abnormalities occurring in later stages of AT.
authors.affiliation: Referral Center for Demyelinating Diseases of the Central Nervous System, University Department of Neurology, Zagreb School of Medicine and Zagreb University Hospital Center, Zagreb, Croatia. mhabek@mef.hr
authors.forename: Mario
authors.initials: M
authors.lastname: Habek
authors.forename: Vesna V
authors.initials: VV
authors.lastname: Brinar
authors.forename: Marko
authors.initials: M
authors.lastname: Rados
authors.forename: Ivana
authors.initials: I
authors.lastname: Zadro
authors.forename: Kamelija
authors.initials: K
authors.lastname: Zarković
mesh_terms: D000328:Adult; D000367:Age Factors; D001254:Astrocytoma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D001260:Ataxia Telangiectasia / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000002:abnormalities* / Q000473:pathology* / Q000503:physiopathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D002526:Cerebellar Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013684:Telangiectasis / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed