Dose-dependent effects of recombinant human interleukin-11 on the systemic hemodynamic function and urination.
The purpose of this study was to determine whether recombinant human interleukin-11 (rhIL-11) could dose-dependently improve the hemodynamic function. Using a swine hemorrhagic shock model, rhIL-11 was given at the beginning of resuscitation. The animals were randomized to receive a single dose of rhIL-11 (5, 20, or 50 microg/kg, group I to III for respectively) or saline (group IV). Blood, urine and both pleural and peritoneal effusion were thus obtained and analyzed. The mean arterial pressure (MAP) was higher post-resuscitation (PR) in group III (62.9+/-8.2 mmHg) than in groups I, II and IV (54.9+/-1.7, 53.9+/-4.3, 55.9+/-9.4 mmHg, respectively) (P<0.01). The urine output (I: 999+/-428, II: 1249+/-180, III: 1434+/-325, IV: 958+/-390 ml) and the cardiac output (CO) (I: 3.01+/-0.66, II: 3.30+/-0.49, III: 3.43+/-0.57, IV: 2.73+/-0.49 L/min.) increased in a dose dependent manner of rhIL-11. CO level and urine output were significantly higher in group III than in group IV (P<0.05). In addition, the volume of third space fluid loss (pleural and peritoneal effusion) of group III was significantly lower than other groups (I: 157+/-32, II: 138+/-32, III: 82+/-21, IV: 125+/-32 ml) (P<0.05). In conclusion, even a low dose of rhIL-11 improved the hemodynamic functions dose-dependently in a porcine model of hemorrhagic shock, although the relationship did not demonstrate a simple linearity.
Honma
Kaneatsu
K
Division of Operative Management, Koga Hospital 21, Kurume, Japan. khonma@tc5.so-net.ne.jp
Koles
Nancy L
NL
Alam
Hasan B
HB
Keith
James C
JC
Pollack
Matthew
M
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D017370:Interleukin-11 / Q000494:pharmacology* / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology; D013552:Swine; D014554:Urination / Q000187:drug effects*
D017370:Interleukin-11; D011994:Recombinant Proteins