[Acute arrest of hemopoiesis mimics aplastic anemia: 23 cases report].
OBJECTIVE
To reveal the clinical features of patients with acute arrest of hemopoiesis (AAH), and explore the dissimilarity between AAH, severe aplastic anemia (SAA) and very severe aplastic anemia (vSAA).


METHODS
The clinical and laboratory features of 23 AAH patients diagnosed and treated in our hospital from May 1993 to May 2006 were analysed retrospectively and compared to the 111 cases of SAA and vSAA patients diagnosed at anaemia therapeutic centre of the hospital from Jul 2002 to May 2006.


RESULTS
Twenty-three patients accorded with the criteria for AAH, and 16 of them with the criteria for severe acute arrest of hemopoiesis (SAAH). They could spontaneously reconstitute their bone marrow hematopoiesis at a median of 17 days (range, 8-50), and had remarkable older age (median age 35.5 vs 21), positive history of other disease and taking medication. Fever as one of presenting symptom were noticed in 10 of 16 STAA patients. The laboratory results were similar with SAA or vSAA, had more frequent decreased serum albumin level and total iron binding capacity and higher CFU-GM.


CONCLUSIONS
Patients with AAH often had similar clinical symptoms with SAA or vSAA. Although they were diagnosed retrospectively, identification of the pathogenesis and laboratory examination may help for the early diagnosis.
Yan
Zhang-Song
ZS
Institute of Hematology and Blood Disease Hospital, CAMS & PUMC, Tianjin, China.
Zhang
Li
L
Wang
Hui-Jun
HJ
Zhou
Kang
K
Li
Jian-Ping
JP
Huang
Zhen-Dong
ZD
Wan
Li
L
Shang
Lei
L
Bao
Xue-Lin
XL
Zhang
Feng-Kui
FK
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies