title: Urine analysis of patients exposed to phenylarsenic compounds via accidental pollution.
abstract: New methods involving high-performance liquid chromatography/inductively coupled plasma mass spectrometry were examined for the determination of phenylarsenic compounds derived from chemical warfare agents. Several methods were examined for the separation of diphenylarsinic acid (DPAA), phenylarsonic acid, phenylmethylarsinic acid (PMAA), phenyldimethylarsine oxide, and diphenylmethylarsine oxide. Analysis of the urine samples of the patients exposed to phenylarsenic compounds indicated that the main phenylarsenic components were DPAA and PMAA; moreover, some unknown arsenicals, which were also found in contaminated groundwater and rice samples, were also detected.
authors.affiliation: Laboratory of Environmental Chemodynamics, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. k2_theory@yahoo.co.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Ayano
authors.initials: A
authors.lastname: Noguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishii
authors.forename: Akira
authors.initials: A
authors.lastname: Tamaoka
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ochi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kaise
mesh_terms: D000059:Accidents; D000818:Animals; D001152:Arsenicals / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004785:Environmental Pollutants / Q000652:urine*; D006801:Humans; D013058:Mass Spectrometry; D051379:Mice
chemical_list: D001152:Arsenicals; D004785:Environmental Pollutants