Cutaneous cancer stem cells: beta-catenin strikes again.
Cancer stem cells (CSCs) are a subpopulation of tumor cells that retain properties of tissue-specific stem cells, including the ability to self-renew. In a recent article in Nature, Malanchi et al. (2008) identified a population of CD34(+) cells in epidermal tumors that require beta-catenin signaling to maintain a CSC phenotype.
Braun
Kristin M
KM
Centre for Cutaneous Research, Barts and The London School of Medicine and Dentistry, Institute of Cell and Molecular Science, 4 Newark Street, London E1 2AT, UK. k.braun@qmul.ac.uk
D000818:Animals; D018952:Antigens, CD34; D018859:Hair Follicle / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000473:pathology / Q000502:physiology; D051379:Mice; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology*; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology; D014410:Tumor Stem Cell Assay; D051176:beta Catenin / Q000502:physiology*
D018952:Antigens, CD34; D051176:beta Catenin