A Cu(I)-catalyzed C-H alpha-amination of esters. Direct synthesis of hydantoins.
This paper describes a novel intermolecular alpha-amination process of esters using CuCl as catalyst and di-tert-butyldiaziridinone as nitrogen source. A variety of hydantoins can be formed effectively under mild reaction conditions.
Zhao
Baoguo
B
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Du
Haifeng
H
Shi
Yian
Y
D000586:Amination; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D002414:Cations, Monovalent / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004952:Esters / Q000737:chemistry*; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry
D001388:Aziridines; D002414:Cations, Monovalent; D004952:Esters; D006827:Hydantoins; C527442:di-tert-butyldiaziridinone; D003300:Copper