title: Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP study.
abstract: We report rates of regression and associated findings in a population derived group of 255 children aged 9-14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems.
authors.affiliation: Newcomen Centre, Guy's & St. Thomas' NHS Foundation Trust, London, SE1 9RT, UK. gillian.baird@gstt.nhs.uk
authors.forename: Gillian
authors.initials: G
authors.lastname: Baird
authors.forename: Tony
authors.initials: T
authors.lastname: Charman
authors.forename: Andrew
authors.initials: A
authors.lastname: Pickles
authors.forename: Susie
authors.initials: S
authors.lastname: Chandler
authors.forename: Tom
authors.initials: T
authors.lastname: Loucas
authors.forename: David
authors.initials: D
authors.lastname: Meldrum
authors.forename: Iris
authors.initials: I
authors.lastname: Carcani-Rathwell
authors.forename: Devanitha
authors.initials: D
authors.lastname: Serkana
authors.forename: Emily
authors.initials: E
authors.lastname: Simonoff
mesh_terms: D020817:Asperger Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001321:Autistic Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D012043:Regression, Psychology