title: Prognostic value of normal adenosine-stress cardiac magnetic resonance imaging.
abstract: We investigated the prognostic value of normal adenosine stress cardiac magnetic resonance (CMR) in suspected coronary artery disease (CAD). Prospectively enrolled in the study were 218 patients with suspected CAD, no stress hypoperfusion, and no delayed enhancement in CMR, and consecutively deferred coronary angiography. The primary end point was a 12-month rate of major adverse cardiac events (MACE; cardiovascular mortality, myocardial infarction, revascularization, hospitalization due to cardiovascular event). CMR indication was symptomatic angina (Canadian Cardiovascular Society II in 42% and III in 7%) or evaluation of myocardial ischemia in patients with arrhythmia, syncope, and/or equivocal stress tests and cardiovascular risk factors (51%). As the main result, the 12-month MACE rate was 2/218 (1 stent implantation, 1 bypass surgery) and CMR negative predictive value 99.1%. There was no cardiac death or myocardial infarction. In conclusion, normal adenosine stress CMR predicts a very low MACE rate and an excellent 1-year prognosis in patients with suspected CAD. Our results provide clinical reassurance that patients at risk for CAD-associated MACE were not missed by CMR. Hence, CMR may serve as a reliable noninvasive gatekeeper to reduce the number of redundant coronary angiographies.
authors.affiliation: Department of Cardiology, Clinic Agatharied, Academic Teaching Hospital of the University of Munich, Haushan, Germany. pilz@khagatharied.de
authors.forename: Guenter
authors.initials: G
authors.lastname: Pilz
authors.forename: Andrea
authors.initials: A
authors.lastname: Jeske
authors.forename: Markus
authors.initials: M
authors.lastname: Klos
authors.forename: Eman
authors.initials: E
authors.lastname: Ali
authors.forename: Berthold
authors.initials: B
authors.lastname: Hoefling
authors.forename: Roland
authors.initials: R
authors.lastname: Scheck
authors.forename: Peter
authors.initials: P
authors.lastname: Bernhardt
mesh_terms: D000241:Adenosine / Q000008:administration & dosage; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D003937:Diagnosis, Differential; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine