title: Kinetic analysis of the MAPK and PI3K/Akt signaling pathways.
abstract: Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.
authors.affiliation: Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. BOX 131, Cheongryang, Seoul 130-650, Korea.
authors.forename: Suresh Babu
authors.initials: SB
authors.lastname: C V
authors.forename: Sheikh Md Enayetul
authors.initials: SM
authors.lastname: Babar
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Song
authors.forename: Eulsik
authors.initials: E
authors.lastname: Oh
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Yoo
mesh_terms: D003198:Computer Simulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D007700:Kinetics; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D048490:raf Kinases / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D020800:Receptor, Nerve Growth Factor; D019869:Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors; D051057:Proto-Oncogene Proteins c-akt; D048490:raf Kinases; D048049:Extracellular Signal-Regulated MAP Kinases