[Role of cytokines in the modulation of lymphocytic subpopulational composition in patients with pulmonary tuberculosis].
The parameters of the lymphocytic CD-population composition and the production of cytokines in the cell cultures of peripheral blood mononuclear cells were studied in patients with infiltrative pulmonary tuberculosis. A marked reduction in the relative and absolute count of CD3+ and CD4+ lymphocytes and an increase in the level of CD8- and CD16-positive cells were established in both drug-sensitive and drug-resistant types of the disease. A significant increase in the production of IL-12 and a reduction in the spontaneous elaboration of interferon-gamma were observed in all the examinees. Addition of lipid and protein myobacterial antigens (Beijing strains) caused a notable decrease in the generation of the study cytokines as compared with the respective parameters in healthy donors and their basal secretion irrespective of the type of a tuberculous process.
Khasanova
R R
RR
Voronkova
O V
OV
Urazova
O I
OI
Novitskiĭ
V V
VV
Strelis
A K
AK
Kolosova
A E
AE
Stambula
Iu V
IuV
Serebriakova
V A
VA
Naslednikova
I O
IO
Kolokova
O V
OV
Vasil'eva
O A
OA
Budkina
T E
TE
D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines