Short-term hyperglycemic dysregulation in patients with type 1 diabetes does not change myocardial triglyceride content or myocardial function.
OBJECTIVE
To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes.


METHODS
Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10).


RESULTS
Mean insulin infusion rate was 45 +/- 5 units at baseline, whereas it was 27 +/- 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 +/- 0.6 to 15.9 +/- 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 +/- 0.05 to 0.46 +/- 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function.


CONCLUSIONS
Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.
Hammer
Sebastiaan
S
Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands. s.hammer@lumc.nl
Jonker
Jacqueline T
JT
Lamb
Hildo J
HJ
van der Meer
Rutger W
RW
Zondag
Wendy
W
Sepers
Jan M
JM
de Roos
Albert
A
Smit
Johannes W A
JW
Romijn
Johannes A
JA
D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006334:Heart Function Tests; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides