[Role of the duodenal and hepatic cells lysosomes in the phenomenon of gadolinium accumulation].
The behaviour of the intestinal mucosa and of the liver after an administration of a gadolinium salt has been studied in the Wistar rat using transmission electron microscopy, ion mass spectrometry, and electron probe microanalysis. Six hours after parenteral administration, gadolinium is concentrated with phosphorus in the lysosomes of hepatocytes and Küppfer cells. Six hours after its oral administration, gadolinium is detected in the duodenal enterocytes lysosomes, but never in those of the liver cells. It is suggested that this mechanism of local concentration limits the diffusion through the digestive barrier of foreign elements, some of them being toxic and none of them having a physiological function.
Ayadi
Ahlem
A
Laboratoire de physiologie, faculté de médecine de Tunis, 15, rue Jbel-Lakhdhar, 1007 Bâab Sâadoun, Tunis, Tunisie. ayadi.ahlem@yahoo.fr
El Hili
Ali
A
Galle
Pierre
P
Tekaya
Leila
L
D000284:Administration, Oral; D000818:Animals; D004386:Duodenum / Q000166:cytology* / Q000502:physiology*; D004577:Electron Probe Microanalysis; D020895:Enterocytes / Q000187:drug effects / Q000378:metabolism; D005682:Gadolinium / Q000493:pharmacokinetics*; D022781:Hepatocytes / Q000502:physiology*; D007263:Infusions, Parenteral; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000166:cytology* / Q000502:physiology*; D008247:Lysosomes / Q000378:metabolism / Q000502:physiology*; D008297:Male; D013058:Mass Spectrometry; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017208:Rats, Wistar
D005682:Gadolinium