title: A carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation in vitro.
abstract: The antioxidative effect of the carotenoids phytoene and phytofluene in biological systems has not yet been studied. We therefore sought to investigate the effect of these carotenoids, isolated from the alga Dunaliella bardawil, in a biological system and used the in vitro low density lipoprotein (LDL) oxidation method to assay their antioxidative effects. We found that similar to beta-carotene and alpha-tocopherol, a carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation. These findings and the presence of phytoene and phytofluene in human tissues suggest that they can be part of the defense system against oxidative stress.
authors.affiliation: The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel. aviv.shaish@sheba.health.gov.il
authors.forename: Aviv
authors.initials: A
authors.lastname: Shaish
authors.forename: Ayelet
authors.initials: A
authors.lastname: Harari
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Kamari
authors.forename: Etienne
authors.initials: E
authors.lastname: Soudant
authors.forename: Dror
authors.initials: D
authors.lastname: Harats
authors.forename: Ami
authors.initials: A
authors.lastname: Ben-Amotz
mesh_terms: D002338:Carotenoids / Q000494:pharmacology*; D056890:Eukaryota / Q000737:chemistry*; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D008077:Lipoproteins, LDL; D002338:Carotenoids; C003140:phytofluene; C100185:(all-E) phytoene