Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism.
BACKGROUND
Somatic symptoms are common in conditions such as fibromyalgia (FM) and chronic fatigue syndrome (CFS).


OBJECTIVE
Authors investigated a potential shared pathologic mechanism: a generalized perceptual abnormality where there is heightened responsiveness to varied sensory stimulation, including pain.


METHODS
A composite measure of sensory sensitivity was created and compared with measures of somatic symptoms, comorbid psychological disturbances, and self-reported physical functioning in 38 patients with FM and/or CFS.


RESULTS
Sensory amplification influenced physical functioning indirectly through pain intensity, and physical symptoms and fatigue also independently contributed to physical functioning.


CONCLUSIONS
Sensory amplification may be an underlying pathophysiologic mechanism in these disorders that is relatively independent of depression and depressive symptoms.
Geisser
Michael E
ME
Chronic Pain and Fatigue Research Center, Dept. of Internal Medicine, Div. of Rheumatology, Univ. of Michigan, Ann Arbor, MI 48108, USA. mgeisser@med.umich.edu
Strader Donnell
Cathy
C
Petzke
Frank
F
Gracely
Richard H
RH
Clauw
Daniel J
DJ
Williams
David A
DA
D000328:Adult; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010146:Pain / Q000175:diagnosis / Q000453:epidemiology; D005082:Physical Exertion; D010809:Physical Fitness / Q000502:physiology; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires