[Why renal transplant from living donors gives better results than cadaver renal transplant?].
BACKGROUND
According to literature, patient and graft survival is better in living donor renal transplants (LRT) than in cadaver renal transplants (CRT).


OBJECTIVE
To study factors that determine the best results in LRT related to those of CRT, found in univariate studies.


METHODS
Renal transplants (RT) done in Catalonia during the 1990-2004 period, performed in patients over 17 years (135 LRT and 3.831 CRT), have been analyzed (retransplants were not included). The data come from the Renal Patients Transplant Registry (RMRC). Student's t-test and chi2 test have been used for mean and for proportions comparisons, respectively. To analyze univariate and multivariate survival, actuarial method and Cox regression have been used, respectively. Estimated creatinine clearance has been studied and its data have been showed through Selwood modified Analysis.


RESULTS
As it happens with other great RT patients series, the RMRC analysis, globally and without any adjustment, shows that patient and graft survival in LRT is better than that obtained with CRT. When we studied which variables explain these results, we found that main factors were smaller recipient age and the short time on dialysis. The great influence of both factors has been published in a large number of papers, explaining the differences obtained on the transplanted renal patient survival.


CONCLUSIONS
Once adjusted the analysis by the different factors that influence the survival of the patient and the graft, there are no differences in the obtained results, since the best outcomes of the TRV are due to factors like the smaller recipient age and the advanced TR.
Guirado
L
L
Unidad de Trasplante Renal, Fundación Puivert, Barcelona.
Vela
E
E
Clèries
M
M
Díaz
J M
JM
Facundo
C
C
García-Maset
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D002102:Cadaver; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome