title: Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles.
abstract: Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an SN2' substitution followed by a subsequent cycloisomerization step.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061, USA.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Chernyak
authors.forename: Surendra Babu
authors.initials: SB
authors.lastname: Gadamsetty
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007536:Isomerism; D009584:Nitrogen / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013696:Temperature
chemical_list: D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D003300:Copper; D009584:Nitrogen