Swelling and aspirin release study: cross-linked pH-sensitive vinyl acetate-co-acrylic acid (VAC-co-AA) hydrogels.
The objective of this work was to develop new pH-sensitive hydrogels to deliver gastric mucosal irritating drugs to the lower part of the gastrointestinal tract. For this purpose, cross-linked vinyl acetate-co-acrylic acid (VAC-co-AA) hydrogels were synthesized by using N, N, methylene bisacrylamide (MBAAm) as a cross-linking agent. Different ratios of 90:10, 70:30, 50:50, 30:70, and 10:90 of VAC-co-AA were synthesized. All of the compositions were cross-linked using 0.15, 0.30, 0.45, and 0.60 mol percent MBAAm. Swelling and aspirin release were studied for 8 hour period. The drug release data were fitted into various kinetic models like the zero-order, first-order, Higuchi, and Peppas. Hydrogels were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. In addition to the above, these hydrogels were loaded with 2%, 8% and 14% w/v aspirin solutions, keeping the monomeric composition and degree of cross-linking constant. In conclusion, it can be said that aspirin can be successfully incorporated into cross-linked VAC/AA hydrogels and its swelling and drug release can be modulated by changing the mole fraction of the acid component in the gels.
Ranjha
Nazar Mohammad
NM
Department of Pharmacy, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. nazar_ranjha@hotmail.com
Mudassir
Jahanzeb
J
D000179:Acrylates / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D003432:Cross-Linking Reagents; D003460:Crystallization; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014753:Vinyl Compounds / Q000737:chemistry*
D000179:Acrylates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D014753:Vinyl Compounds; C036658:acrylic acid; C011566:vinyl acetate; D001241:Aspirin