title: Pulmonary mechanic and lung histology injury induced by Crotalus durissus terrificus snake venom.
abstract: In the present work we investigated the effects of Crotalus durissus terrificus venom (CdtV) on the pulmonary mechanic events [static and dynamic elastance, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)] and histology after intramuscular injection of saline solution (control) or venom (0.6 microg/g). The static and dynamic elastance values were increased significantly after 3 h of venom inoculation, but were reduced at control values in the other periods studied. The DeltaP1 values that correspond to the resistive properties of lung tissue presented a significant increase after 6h of CdtV injection, reducing to basal levels 12h after the venom injection. In DeltaP2 analysis, correspondent to viscoelastic components, an increase occurred 12 h after the venom injection, returning to control values at 24 h. CdtV also caused an increase of leukocytes recruitment (3-24 h) to the airways wall as well as to the lung parenchyma. In conclusion, C. durissus terrificus rattlesnake venom leads to lung injury which is reverted, after 24 h of inoculation.
authors.affiliation: Laboratory of Physiology and Pharmacodynamics, Institute of Research and Development-IP&D, University of Vale do Paraiba-UNIVAP, Sao Jose dos Campos, SP, Brazil.
authors.forename: Paula Naomi
authors.initials: PN
authors.lastname: Nonaka
authors.forename: César Ferreira
authors.initials: CF
authors.lastname: Amorim
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Paneque Peres
authors.forename: César Augusto Melo
authors.initials: CA
authors.lastname: E Silva
authors.forename: Stella R
authors.initials: SR
authors.lastname: Zamuner
authors.forename: Wellington
authors.initials: W
authors.lastname: Ribeiro
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Cogo
authors.forename: Rodolfo P
authors.initials: RP
authors.lastname: Vieira
authors.forename: Marisa
authors.initials: M
authors.lastname: Dolhnikoff
authors.forename: Luis Vicente Franco
authors.initials: LV
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D003435:Crotalid Venoms / Q000008:administration & dosage / Q000633:toxicity*; D017839:Crotalus; D007273:Injections, Intramuscular; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051379:Mice; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000187:drug effects*; D013990:Tidal Volume / Q000187:drug effects / Q000502:physiology
chemical_list: D003435:Crotalid Venoms