title: A mammary gland adenomyoepithelioma in a C57BL/6 mouse.
abstract: Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an adenomyoepithelioma in a C57BL/6 female mouse. Histologically, tubes and cords formed by neoplastic epithelial cells were separated by bundles of neoplastic myoepithelial cells in a clear and partially mucinous matrix. The tumor displayed characteristics of a benign neoplastic proliferation with a compressive growth pattern, and moderate cellular pleomorphism and mitotic index. At immunohistochemistry, the epithelial cells were strongly cytokeratin positive; the myoepithelial cells were weakly cytokeratin positive and strongly smooth muscle actin positive. This is to our knowledge, the first report of a mammary gland adenomyoepithelioma in a C57BL/6 mouse.
authors.affiliation: Department of Pathology, Veterinary School of Alfort, 94704 Maisons-Alfort, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Bauchet
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Elies
authors.forename: Pierre
authors.initials: P
authors.lastname: Maliver
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Fouque
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Balme
authors.forename: Sophie
authors.initials: S
authors.lastname: Château-Joubert
authors.forename: Frédéric
authors.initials: F
authors.lastname: Schorsch
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Fontaine
mesh_terms: D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009208:Myoepithelioma / Q000378:metabolism / Q000473:pathology* / Q000662:veterinary*