Models of multiple sclerosis: new insights into pathophysiology and repair.
OBJECTIVE
Experimental models are indispensable in multiple sclerosis research aimed to elucidate the pathogenesis of the disease or to test new therapeutic approaches. The purpose of this review is to discuss the relevance of different models for multiple sclerosis and new insights into pathophysiology of the disease obtained from experimental studies.


RESULTS
These studies show that tissue damage in the course of brain inflammation is induced by a variety of different components of the immune system, including T cells, autoantibodies and activated effector cells, such as macrophages and microglia. In general, different mechanisms of tissue injury act in parallel and are partly counteracted by the induction of neuroprotective factors and spontaneous regenerative processes.


CONCLUSIONS
Despite this complexity, experimental studies identified bottlenecks in the destructive process, which can be targeted by therapeutic strategies. To what extent these results can be transferred into therapy of multiple sclerosis has to be shown in the future.
Lassmann
Hans
H
Center for Brain Research, Medical University of Vienna, Austria. hans.lassmann@meduniwien.ac.at
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000503:physiopathology*; D005609:Free Radicals / Q000276:immunology; D006801:Humans; D028361:Mitochondrial Diseases / Q000276:immunology / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000276:immunology / Q000503:physiopathology / Q000628:therapy
D001323:Autoantibodies; D005609:Free Radicals