title: Successful treatment with plasma exchange in adult-onset Still's disease with hyper-IL-18-naemia and hyperallergic state.
abstract: Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.
authors.affiliation: First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ito
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Shimamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Amuro
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tanijiri
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoi
authors.forename: Yonsu
authors.initials: Y
authors.lastname: Son
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Tajima
authors.forename: Shirou
authors.initials: S
authors.lastname: Fukuhara
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity / Q000150:complications / Q000628:therapy*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D020382:Interleukin-18 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010951:Plasma Exchange; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000628:therapy*
chemical_list: C508600:IL6 protein, human; D020382:Interleukin-18; D015850:Interleukin-6; D007371:Interferon-gamma