Synthesis of N-substituted indole-3-carboxylic acid derivatives via Cu(I)-catalyzed intramolecular amination of aryl bromides.
A variety of N-alkylated and N-arylated derivatives of methyl 1 H-indole-3-carboxylate were synthesized efficiently via Ullmann-type intramolecular arylamination, using the CuI-K 3PO 4-DMF system. This catalytic amination procedure can be performed with good to high yields under mild conditions under an air atmosphere.
Melkonyan
Ferdinand S
FS
Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia
Karchava
Alexander V
AV
Yurovskaya
Marina A
MA
D000586:Amination; D001965:Bromides / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy
D001965:Bromides; D007211:Indoles; C012382:indole-3-carboxylic acid; D003300:Copper