title: Surgery and radiotherapy: complementary tools in the management of benign intracranial tumors.
abstract: Historically, radiation therapy has been used extensively in the treatment of malignant and aggressive intracranial tumors, and the importance of its role has been repeatedly verified by prolonged patient survival rates and increased tumor control. As more modern capabilities are employed in surgery and radiotherapy, attention is being directed to the utility of radiation as either primary or secondary treatment of benign tumors. Specifically, primary treatment encompasses irradiation of small benign tumors without biopsy confirmation of tumor type; secondary treatment involves postoperative radiation therapy, with the possibility that less-aggressive tumor resection may be performed in areas that have a higher probability of resultant neurological deficit. Current literature suggests that this is not only a possible treatment strategy, but that it may be superior to more radical resection in some cases, for example, in vestibular schwannomas and meningiomas. This article provides an overview of factors to consider in the use of radiation therapy and reviews the relationships between radiation and surgery, notably the unique complementary role each plays in the treatment of benign intracranial tumors.
authors.affiliation: Department of Neurosurgery, Loma Linda University, Loma Linda, California 92354, USA. wjohnson@llu.edu
authors.forename: Walter D
authors.initials: WD
authors.lastname: Johnson
authors.forename: Lilia N
authors.initials: LN
authors.lastname: Loredo
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Slater
mesh_terms: D000236:Adenoma / Q000532:radiotherapy / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000379:methods; D019583:Dose Fractionation, Radiation; D004601:Elementary Particles / Q000627:therapeutic use; D006801:Humans; D008577:Meningeal Neoplasms / Q000532:radiotherapy / Q000601:surgery; D008579:Meningioma / Q000532:radiotherapy / Q000601:surgery; D009442:Neurilemmoma / Q000000981:diagnostic imaging / Q000532:radiotherapy; D010911:Pituitary Neoplasms / Q000532:radiotherapy / Q000601:surgery; D011868:Radioisotopes / Q000627:therapeutic use; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods; D011881:Radiotherapy, Computer-Assisted / Q000379:methods; D014463:Ultrasonography
chemical_list: D011868:Radioisotopes