title: [Pharmacological review of alcoholic dependence treatment].
abstract: The aim of the present pharmacological update is to revise the problem of alcohol dependence. Starting from the biological bases and the impact of alcohol on the neurobiological and neurotransmission systems, a revision of the main pharmacological tools for alcohol dependence treatment will be done. Disulfiram, naltrexone, acamprosate, all of them approved by the FDA (Food and Drug Administration), have shown mechanisms of action, efficacy, tolerance and adherence dissimilar. We will also refer to topiramate, which is being studied for this indication.
authors.affiliation: Hospital Alvarez.
authors.forename: Leandro
authors.initials: L
authors.lastname: Oural
authors.forename: María V
authors.initials: MV
authors.lastname: Paris
authors.forename: Oriana
authors.initials: O
authors.lastname: Sullivan
authors.forename: Martina
authors.initials: M
authors.lastname: Polach
authors.forename: Federico
authors.initials: F
authors.lastname: Pavlovsky
authors.forename: José
authors.initials: J
authors.lastname: Capece
mesh_terms: D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000009:adverse effects / Q000627:therapeutic use*; D000437:Alcoholism / Q000534:rehabilitation*; D004221:Disulfiram / Q000009:adverse effects / Q000627:therapeutic use*; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D009271:Naltrexone / Q000009:adverse effects / Q000627:therapeutic use*; D013654:Taurine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077236:Topiramate
chemical_list: D000427:Alcohol Deterrents; D000077236:Topiramate; D013654:Taurine; D005632:Fructose; D009271:Naltrexone; D000077443:Acamprosate; D004221:Disulfiram