Regulatory T cells in paraneoplastic neurological syndromes.
Focusing on CD4(+)CD25(+) regulatory T lymphocytes (T(reg)), we studied the gene expression of T(reg) functional molecules in peripheral blood lymphocytes of patients with paraneoplastic neurological syndrome (PNS), including Lambert-Eaton myasthenic syndrome (LEMS) with small cell lung carcinoma (SCLC) and anti-Hu- or anti-Yo-antibody-positive PNS. T(reg)-rich subsets were sorted from the patients' peripheral blood mononuclear cells, and the mRNA expression levels of their functional genes were measured. The expression levels of FOXP3, TGF-beta and CTLA4 mRNA in T(reg)-rich subsets of PNS patients were down-regulated compared with that of SCLC patients without PNS. These results suggest that T(reg) dysfunction plays a role in PNS development.
Tani
Takashi
T
Neurology, Brain Research Institute of Niigata University, Asahimachi Dori 1-757, Niigata-shi, Niigata, Japan.
Tanaka
Keiko
K
Idezuka
Jiro
J
Nishizawa
Masatoyo
M
D000328:Adult; D000906:Antibodies / Q000378:metabolism; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D060908:CTLA-4 Antigen; D051959:ELAV Proteins / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000145:classification / Q000473:pathology* / Q000503:physiopathology*; D012333:RNA, Messenger / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism
D000906:Antibodies; D015703:Antigens, CD; C095184:CDR2 protein, human; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D051959:ELAV Proteins; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta