Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture.
Complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone exhibit high biological activity and increase the rate of protein biosynthesis in the culture of rat hepatocytes. An important role in this process is played by reduced delta44-3-keto group in the A-ring of steroid hormones. A complex of apolipoprotein A-I and pregnenolone modulated the rate of protein biosynthesis in liver cells. Hence, the observed changes are not organ-specific for this steroid. Our results suggest that this mechanism of regulation play an important role in intracellular regeneration and proliferation.
Panin
L E
LE
Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Knyazev
R A
RA
Sumenkova
D V
DV
Polyakov
L M
LM
D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D022781:Hepatocytes / Q000166:cytology / Q000502:physiology*; D008297:Male; D046912:Multiprotein Complexes / Q000378:metabolism*; D011284:Pregnenolone / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013760:Tetrahydrocortisol / Q000737:chemistry / Q000378:metabolism*
D016632:Apolipoprotein A-I; D046912:Multiprotein Complexes; D011506:Proteins; D011284:Pregnenolone; D013760:Tetrahydrocortisol