Microarrays--analysis of signaling pathways.
Microarrays provide a powerful means of analyzing the expression level of multiple transcripts in two sample populations. In this study, we have used microarray technology to identify genes that are differentially regulated in response to activin-treated ovarian cancer cells. We find a number of biologically relevant genes that are involved in regulating activin signaling and genes potentially contributing to activin-mediated growth arrest appear to be differentially regulated. Thus, microarrays are an important tool for dissecting gene expression changes in normal physiological processes and disease.
Ramachandran
Anassuya
A
Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Black
Michael A
MA
Shelling
Andrew N
AN
Love
Donald R
DR
D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D010051:Ovarian Neoplasms / Q000235:genetics; D011786:Quality Control; D012313:RNA / Q000737:chemistry; D015398:Signal Transduction; D013194:Staining and Labeling / Q000379:methods; D013223:Statistics as Topic / Q000379:methods*; D014407:Tumor Cells, Cultured; D054928:Validation Studies as Topic
D012313:RNA