title: Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
abstract: BACKGROUND
  Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear.
  
  
  OBJECTIVE
  The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk.
  
  
  METHODS
  This was a multicenter prospective study of 142,520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake.
  
  
  RESULTS
  After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish.
  
  
  CONCLUSIONS
  The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.
authors.affiliation: Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom. francesca.crowe@ceu.ox.ac.uk
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Crowe
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Paul N
authors.initials: PN
authors.lastname: Appleby
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Travis
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Marianne U
authors.initials: MU
authors.lastname: Jakobsen
authors.forename: Nina F
authors.initials: NF
authors.lastname: Johnsen
authors.forename: Anne
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authors.lastname: Tjønneland
authors.forename: Jakob
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authors.lastname: Linseisen
authors.forename: Sabine
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authors.lastname: Rohrmann
authors.forename: Heiner
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authors.lastname: Boeing
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authors.lastname: Pischon
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Pagona
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authors.lastname: Lagiou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Carlotta
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authors.lastname: Sacerdote
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Vitorrio
authors.initials: V
authors.lastname: Krogh
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: Maria-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Nerea
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authors.lastname: Larrañaga
authors.forename: Carlos A
authors.initials: CA
authors.lastname: González
authors.forename: José R
authors.initials: JR
authors.lastname: Quirós
authors.forename: Jonas
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authors.lastname: Manjer
authors.forename: Elisabet
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authors.lastname: Wirfält
authors.forename: Pär
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authors.lastname: Stattin
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrari
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000368:Aged; D003611:Dairy Products; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects; D005060:Europe / Q000453:epidemiology; D005247:Feeding Behavior; D006801:Humans; D008297:Male; D008460:Meat / Q000009:adverse effects; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D017747:Seafood; D011795:Surveys and Questionnaires
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated