[Neural plasticity mechanism of depression].
The current hypothesis of depression is limited by back reasoning from the action of antidepressant, because both the pharmacological and pathological mechanisms are not fully understood.Recent evidence shows that genes and early life stress are associated with depression, and the mechanisms are converged on those of neural plasticity. These developments open a new avenue to understand the pathological and pharmacological mechanisms of depression.
Xu
Lin
L
Key Laboratory of Animal Models and Human Disease Mechanism, Institute of Zoology in Kunming, Chinese Academy of Sciences, Kunming, China. lxu@vip.163.com
D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects
D000928:Antidepressive Agents