Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.
A recent scan of single nucleotide polymorphisms (SNPs) in the region 40-107 Mb on chromosome 10q in a large Japanese case-control cohort identified six SNPs in or near the dynamin-binding protein gene (DNMBP) that were associated with late onset Alzheimer's disease (LOAD) in individuals lacking the APOE epsilon4 allele [Kuwano et al. (2006); Hum Mol Genet 15:2170-2182]. We genotyped these six SNPs in 1,212 unrelated Caucasian patients of UK origin with LOAD and 1,389 ethnically, gender and age matched control subjects. We did not observe a statistically significant association with the risk of LOAD for any of the six SNPs in the sample as a whole. When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the epsilon4 allele (genotypic P = 0.027, allelic P = 0.066). However this association was in the opposite direction to that detected in the Japanese population. It remains to be determined whether DNMBP is associated with LOAD.
Morgan
A R
AR
Department of Psychological Medicine, School of Medicine, Cardiff University, UK. morganar1@cardiff.ac.uk
Hollingworth
P
P
Abraham
R
R
Lovestone
S
S
Brayne
C
C
Rubinsztein
D C
DC
Lynch
A
A
Lawlor
B
B
Gill
M
M
O'Donovan
M C
MC
Owen
M J
MJ
Williams
J
J
D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10; D003598:Cytoskeletal Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D006113:United Kingdom; D044465:White People
D053327:Apolipoprotein E4; D003598:Cytoskeletal Proteins; C482331:DNMBP protein, human