Cost-effectiveness analysis of chemotherapy for advanced gastric cancer in China.
OBJECTIVE
To assess the economics of various chemotherapeutic regimens for advanced gastric cancer (AGC), and to select the best cost-effective regimen for the common Chinese patients.


METHODS
Data source used in this study was the Chinese Biomedical Disk Database. Patients were diagnosed as AGC and any regimen was eligible. Outcome measures included median survival time (MST) and percentage of complete and partial response (CR+PR). Economic statistics was per capita direct medical cost (DMC) of a single cycle. TreeAge Pro Healthcare 2007 software was used to carry out cost-effectiveness and incremental cost-effectiveness analysis. Sensitivity analyses were applied by altering willingness-to-pay and annual discount rate, and also re-analyzed by excluding the studies with apparent heterogeneity.


RESULTS
Seven retrospective economics studies on 760 patients were included. 5-fluorouracil-based regimens were universal, and also some new agents were involved, such as docetaxel, paclitaxel, and oxaliplatin. By processing analysis, we could recommend etoposide, leucovorin and 5-fluorouracil (ELF) regimen as preference, with a DMC/MST ratio of 2543 RBM/11.7 mo and a DMC/CR+PR ratio of 2543 RMB/53.3%. Uracil-tegafur, etoposide and cisplatin (FEP) or 5-fluorouracil, adrimycin/epirubin and mitomycin (FAM) regimens could be regarded as optional first-line chemotherapy for AGC in common Chinese patients. With no regard for willingness-to-pay, the docetaxel, cisplatin and 5-fluorouracil (DCF) regimen could be chosen as either a first- or a second-line chemotherapy, with a DMC/CR+PR ratio of 9979 RMB/56.3%.


CONCLUSIONS
5-fluorouracial regimens are still considered the mainstream for AGC, while new agents such as taxanes are optional. More randomized clinical trials are required before any mandatory recommendation of certain regimens for patients with AGC in China is made.
Chen
Xin-Zu
XZ
Department of Gastrointestinal Surgery, and Multidisciplinary Treatment Team of Gastrointestinal Tumors, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Jiang
Kun
K
Hu
Jian-Kun
JK
Zhang
Bo
B
Gou
Hong-Feng
HF
Yang
Kun
K
Chen
Zhi-Xin
ZX
Chen
Jia-Ping
JP
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000191:economics* / Q000401:mortality / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000191:economics* / Q000627:therapeutic use*; D002681:China; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D005472:Fluorouracil / Q000008:administration & dosage / Q000191:economics; D006801:Humans; D009367:Neoplasm Staging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000191:economics* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D043823:Taxoids / Q000008:administration & dosage / Q000191:economics; D016896:Treatment Outcome
D043823:Taxoids; D005472:Fluorouracil