Clofibrate and dalargin increase luminol-dependent chemiluminescence of mouse blood.
The effects of hypolipidemic drug clofibrate and polypeptide dalargin on activity of the neutrophil peroxidase system in mice were studied using the method of luminol-enhanced chemiluminescence. Clofibrate and dalargin increased the chemiluminescence of mouse whole blood. Their combined use several-fold potentiated this effect. It is expected that combined use of hypolipidemics and polypeptides will open a new trend in the search for stimulators of oxygen-dependent nonspecific immunity.
Mushtakova
V M
VM
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow. kar_12225@orc.ru
Rogovin
V V
VV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D002994:Clofibrate / Q000378:metabolism*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000378:metabolism*; D049449:Luminescence; D049408:Luminescent Agents / Q000378:metabolism; D008165:Luminol / Q000378:metabolism*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000378:metabolism
D000975:Antioxidants; D000960:Hypolipidemic Agents; D049408:Luminescent Agents; D008165:Luminol; D016308:Enkephalin, Leucine-2-Alanine; D002994:Clofibrate; C040996:enkephalin-Leu, Ala(2)-Arg(6)-