Significance of soluble CD40 ligand, adiponectin and reactive oxygen metabolites in aging.
We analyzed the association between platelet activation, adiponectin, insulin resistance and oxidative stress in aging. In addition, we included American football (AB) players to investigate whether this association is modulated by exercise. Eighty-six old age patients (> or = 65 years old) hospitalized at the nursing institution and 62 AB players were recruited as study subjects. Reactive oxygen metabolites (ROM), soluble CD40 ligand (sCD40L) and adiponectin were estimated with these patients. In comparison to old age, plasma adiponectin levels in AB players were significantly low. In addition, the adiponectin values of elder group (> 80 years) in old age were significantly increased higher than those for younger group (< or = 80 years). There were no differences of sCD40L in two groups. Levels of ROM in AB players were also significantly lower than that in old age. However, the ROM values of younger group in old age were significantly increased higher than those for elder group. The sCD40L also exhibited the same results. There were no significant differences in ROM and adiponectin levels between the high homeostasis model assessment-insulin resistance (HOMA-IR) (> 2.0) and the low HOMA-IR (< or = 2.0). In contrast, in the old age, the sCD40L and ROM levels in the high HOMA-IR group were significantly higher than those in the low HOMA-IR group. In addition, the adiponectin level in the high HOMA-IR group was significantly lower than that in the low HOMA-IR group. Our results suggest that platelet activation, adiponectin and oxidative stress are the very important factors for aging, and the maintenance of exercise could prevent the occurrence of metabolic syndrome or insulin resistance.
Inami
Norihito
N
Second Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8507, Japan.
Nomura
Shosaku
S
Inami
Osamu
O
Kimura
Yutaka
Y
Urase
Fumiaki
F
Maeda
Yasuhiro
Y
Iwasaka
Toshiji
T
D052242:Adiponectin / Q000378:metabolism*; D000368:Aged; D000375:Aging / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism*
D052242:Adiponectin; C526581:CD40LIg fusion protein; D017382:Reactive Oxygen Species; D011993:Recombinant Fusion Proteins