title: Poly(D,L-lactide) nanoencapsulation to reduce photoinactivation of a sunscreen agent.
abstract: The use of sunscreens is the 'gold standard' for protecting the skin from ultraviolet light. Octyl methoxycinnamate (OMC) is one of the most widely used UVB filter but it can act as a sensitizer or photoallergen. When exposed to sunlight, OMC can change from the primary trans-form to cis-form and the isomerization, not reversible, conducts to a reduction of the UVB filtering efficiency because the trans-form has a higher extinction coefficient. Photostability is the most important characteristic of effective sunscreens and it can be influenced by formulation ingredients and by applying technological strategies. In this work, photostability experiments, performed on emulsion-gels containing different percentages of OMC free or loaded in poly(D,L-lactide) nanoparticles, were carried out. The presence of a polymeric envelop may act to protect the active ingredient. In this study, the influence of poly(D,L-lactide) matrices on the photochemical stability of the sunscreen agent was investigated. As highlighted in this study, free OMC in different formulations has different photoisomerization degree. Moreover, a dissimilar behaviour was observed by studying different sunscreen concentrations in the same cosmetic formulation. Photostability results show a significant reduction in photoisomerization degree for formulations containing sunscreen loaded in nanoparticles, highlighting that the encapsulation is a suitable strategy to improve OMC photostability. Moreover, sun protection factor (SPF) results show that the UVB filter protective power is also maintained after encapsulation.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Pavia, 27100 Pavia, Italy. manuela.vettor@unipv.it
authors.forename: M
authors.initials: M
authors.lastname: Vettor
authors.forename: P
authors.initials: P
authors.lastname: Perugini
authors.forename: S
authors.initials: S
authors.lastname: Scalia
authors.forename: B
authors.initials: B
authors.lastname: Conti
authors.forename: I
authors.initials: I
authors.lastname: Genta
authors.forename: T
authors.initials: T
authors.lastname: Modena
authors.forename: F
authors.initials: F
authors.lastname: Pavanetto
mesh_terms: D002934:Cinnamates / Q000737:chemistry* / Q000528:radiation effects; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D007536:Isomerism; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013473:Sunscreening Agents / Q000737:chemistry* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D002934:Cinnamates; D004655:Emulsions; D011091:Polyesters; D013473:Sunscreening Agents; C033616:poly(lactide); C118580:octylmethoxycinnamate