title: Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion.
abstract: Recently, we found that unsaturated long-chain fatty acids (such as alpha-linolenic acid) promote the secretion of glucagon-like peptide-1 (GLP-1) via G protein-coupled receptor GPR120, which is expressed predominantly in the colon. In order to ensure that the triglycerides or free fatty acids, such as alpha-linolenic acid, reach the distal intestinal tract effectively, we developed a Calshell technique. Following single treatment of Calshell perilla oil powder, the GLP-1 secretion level was significantly higher than following vehicle treatment, 120 min after treatment. Next, we examined the effects of long-term Calshell perilla oil powder treatment on GLP-1 secretion. Plasma GLP-1 level of Calshell perilla oil powder treatment was significantly higher than of vehicle treatment for 1, 14, 28 and 56 d. We thereby demonstrated for the first time the utility of Calshell oil powder treatment for effective and sustainable GLP-1 secretion. The Calshell technique is apparently useful as a drug delivery system, since Calshell unsaturated oil powder is protected from gastric acid, reaches enteroendocrine cells in the gastrointestinal tract, and then induces effective incretin secretion.
authors.affiliation: Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. adachi-tet@umin.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Adachi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanaka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kanai
authors.forename: Mayu
authors.initials: M
authors.lastname: Nozaki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takahara
authors.forename: Mariko
authors.initials: M
authors.lastname: Tsuda
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Jonouchi
authors.forename: Kinsuke
authors.initials: K
authors.lastname: Tsuda
authors.forename: Akira
authors.initials: A
authors.lastname: Hirasawa
authors.forename: Gozoh
authors.initials: G
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000096:biosynthesis*; D007328:Insulin / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010938:Plant Oils / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D011208:Powders; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D004337:Drug Carriers; D007328:Insulin; D010938:Plant Oils; D011208:Powders; D017962:alpha-Linolenic Acid; C058216:perilla seed oil; D052216:Glucagon-Like Peptide 1