A doxycycline hyclate rodent bait formulation for prophylaxis and treatment of tick-transmitted Borrelia burgdorferi.
The prophylactic and curative potential of doxycycline hyclate formulated in a rodent bait at concentrations of 250 and 500 mg/Kg was evaluated in a murine model of Lyme borreliosis. Both bait formulations prevented tick-transmitted Borrelia burgdorferi infection in 100% of C3H/HeJ mice (N = 16), as well as cured acute, established infection in mice (N = 8) exposed to bait for 14 days. Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. These data provide evidence for exploring alternative techniques to prevent transmission of Lyme disease spirochetes.
Dolan
Marc C
MC
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado 80521, USA. mcd4@cdc.gov
Zeidner
Nordin S
NS
Gabitzsch
Elizabeth
E
Dietrich
Gabrielle
G
Borchert
Jeff N
JN
Poché
Rich M
RM
Piesman
Joseph
J
D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D025065:Borrelia burgdorferi / Q000187:drug effects*; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008193:Lyme Disease / Q000188:drug therapy* / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D013987:Ticks / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D004318:Doxycycline