New alpha-pyrrolidinonoids and glycosides from Euphorbia humifusa.
A phytochemical investigation on the constituents from Euphorbia humifusa Willd. has resulted in the isolation of three new alpha-pyrrolidinonoidal compounds, 5beta-methoxy-4beta-hydroxy-3-methylene-alpha-pyrrolidinone (1), 5beta-methoxy-4alpha-hydroxy-3-methylene-alpha-pyrrolidinone (2), and 5beta-butoxy-4alpha-hydroxy-3-methylene-alpha-pyrrolidinone (3), and three new glycosides including an indole glycoside, 3-(2-hydroxyethyl)-5-(1-O-beta-glucopyranosyloxy)-indole (4), an ionone glycoside, 3-oxo-7,8-dihydro-alpha-ionone-11-O-beta-glucoside (5), and a hemiterpene glycoside, 1-(4-hydroxy-2-methyl-2-buten-1-yl)-6- (3,4,5-trihydroxybenzoyl)-beta-d-glucose (6), along with 10 known compounds. Their structures were elucidated by analysis of 1D and 2D NMR spectral data. The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis.
Deng
Fei
F
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Tang
Na
N
Xu
Jun
J
Shi
Yu-Hua
YH
Zhao
Ming
M
Zhang
Jin-Sheng
JS
D004365:Drugs, Chinese Herbal / Q000737:chemistry; D028481:Euphorbia / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification*
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D011760:Pyrrolidinones