title: Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction.
abstract: The development of a radiation-induced sarcoma (RIS) in the post mastectomy thoracic treatment volume is an infrequent, but recognized, event. Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment. We present a case of leiomyosarcoma in a patient who underwent mastectomy followed by radiotherapy for invasive ductal carcinoma. A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later. This report analyzes the diagnostic and therapeutic approach of patients with RIS.
authors.affiliation: Surgery Department, Hospital General de Alicante, 03010 Alicante, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Olcina
authors.forename: B
authors.initials: B
authors.lastname: Merck
authors.forename: M J
authors.initials: MJ
authors.lastname: Giménez-Climent
authors.forename: S
authors.initials: S
authors.lastname: Almenar
authors.forename: M F
authors.initials: MF
authors.lastname: Sancho-Merle
authors.forename: F
authors.initials: F
authors.lastname: Llopis
authors.forename: C
authors.initials: C
authors.lastname: Vázquez-Albadalejo