title: Application of MEMS technology and engineering in medicine: a new paradigm for facial muscle reanimation.
abstract: Translational research may lead to development of micro-electromechanical system-based devices to treat muscle and nerve dysfunctions whose current treatments are inadequate and, at best, palliative. This paper discusses the development of engineered microsystems as a treatment option for palsies of the seventh cranial nerve and the potential application of these devices as a platform technology for treatment of other nervous dysfunctions. The engineering techniques for electrical and chemical stimulation of denervated muscle are discussed along with current caveats from clinical and engineering standpoints. As opposed to current treatments, miniaturized implants offer the possibility of the reduced toxicity and increased specificity of direct drug delivery. As with the increased miniaturization of other technologies, engineering of these increasingly small implantable microsystems holds great promise for the future development of yet smaller, even nanoscale, implantable devices.
authors.affiliation: Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA. kpcorb@aol.com
authors.forename: Kimberly
authors.initials: K
authors.lastname: Cockerham
authors.forename: Seppo
authors.initials: S
authors.lastname: Aro
authors.forename: Wentai
authors.initials: W
authors.lastname: Liu
authors.forename: Oxana
authors.initials: O
authors.lastname: Pantchenko
authors.forename: Andrea
authors.initials: A
authors.lastname: Olmos
authors.forename: Mark
authors.initials: M
authors.lastname: Oehlberg
authors.forename: Mohanasankar
authors.initials: M
authors.lastname: Sivaprakasam
authors.forename: Lauren
authors.initials: L
authors.lastname: Crow
mesh_terms: D016503:Drug Delivery Systems; D004558:Electric Stimulation; D005152:Facial Muscles / Q000473:pathology*; D006801:Humans; D013677:Medical Laboratory Science / Q000379:methods*; D036103:Nanotechnology; D009422:Nervous System Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*