NMR-guided fragment-based approach for the design of AAC(6')-Ib ligands.
Lombès
Thomas
T
Chimie Thérapeutique, UMR 8638, Université Paris Descartes, CNRS, 4 avenue de l'Observatoire, 75006 Paris, France.
Bégis
Guillaume
G
Maurice
Frédérique
F
Turcaud
Serge
S
Lecourt
Thomas
T
Dardel
Frédéric
F
Micouin
Laurent
L
D000123:Acetyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000617:Aminoglycosides / Q000378:metabolism; D001665:Binding Sites; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011485:Protein Binding
D000617:Aminoglycosides; D004791:Enzyme Inhibitors; D008024:Ligands; D000123:Acetyltransferases; C056532:aminoglycoside N(6')-acetyltransferase