title: Role of ErbB4 in breast cancer.
abstract: Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of normal mammary gland physiology, and aberrations in their signaling have been associated with breast tumorigenesis. Therapeutics targeting epidermal growth factor receptor (EGFR = ErbB1) or ErbB2 in breast cancer have been approved for clinical use. In contrast, relatively little is known about the biological significance of ErbB4 signaling in breast cancer. This review focuses on recent advances in our understanding about the role of ErbB4 in breast carcinogenesis, as well as in the potential clinical relevance of ErbB4 in breast cancer prognostics and therapy.
authors.affiliation: Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
authors.forename: Maria
authors.initials: M
authors.lastname: Sundvall
authors.forename: Kristiina
authors.initials: K
authors.lastname: Iljin
authors.forename: Sami
authors.initials: S
authors.lastname: Kilpinen
authors.forename: Henri
authors.initials: H
authors.lastname: Sara
authors.forename: Olli-Pekka
authors.initials: OP
authors.lastname: Kallioniemi
authors.forename: Klaus
authors.initials: K
authors.lastname: Elenius
mesh_terms: D017398:Alternative Splicing; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016503:Drug Delivery Systems; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020880:Neuregulins / Q000378:metabolism; D011379:Prognosis; D066247:Receptor, ErbB-4; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; D020880:Neuregulins; C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4