title: Thyroid as a target of metastases. A case of foregut neuroendocrine carcinoma with multiple abdominal metastases and a thyroid localization after 21 years.
abstract: The thyroid gland is quite often the target of metastases. For this reason any thyroid nodule in a patient with a previous history of cancer needs to be evaluated. In case of thyroid metastases, the site of the primary tumor is most often the breast, lung or kidney. A thyroid metastasis from a foregut neuroendocrine tumor is very unusual and requires a differential diagnosis with primary neuroendocrine tumor of the gland itself, i.e., a medullary thyroid carcinoma. This case report is peculiar because of the multiple sites of abdominal relapses, the long time interval between relapses (21 years), and the positive outcome after surgical treatment.
authors.affiliation: Otorhinolaryngology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. franco.mattavelli@istitutotumori.mi.it
authors.forename: Franco
authors.initials: F
authors.lastname: Mattavelli
authors.forename: Paola
authors.initials: P
authors.lastname: Collini
authors.forename: Natalia
authors.initials: N
authors.lastname: Pizzi
authors.forename: Carlo
authors.initials: C
authors.lastname: Gervasoni
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pennacchioli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Mazzaferro
mesh_terms: D000328:Adult; D001063:Appendiceal Neoplasms / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D018278:Carcinoma, Neuroendocrine / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000556:secondary*
chemical_list: D014408:Biomarkers, Tumor