Preparation, characterization, and mucoadhesive properties of chitosan-coated microspheres encapsulated with cyclosporine A.
The aim of this study was to prepare and characterize chitosan-coated microspheres containing cyclosporine A (CyA). Microspheres encapsulated with CyA were prepared by solvent evaporation-emulsification methods. Microspheres were immersed in chitosan solution (0.5% w/w) to be coated. Morphology, mean size, and encapsulation efficiency of chitosan-coated microspheres were evaluated. To assess the mucoadhesive properties of this drug delivery system, the percent of mucin adsorption to the surface of coated microspheres was determined. Microspheres were spherical in shape. Encapsulation efficiency of different microsphere formulations varied from 78% to 92%. According to the mucin adsorption results, this particulate system showed suitable mucoadhesive properties. It can be concluded that surface modification of microspheres by chitosan coating would increase the prospects of their usefulness as oral drug delivery systems for CyA.
Malaekeh-Nikouei
Bizhan
B
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran. malaekehb@mums.ac.ir
Sajadi Tabassi
Sayyed A
SA
Jaafari
Mahmoud R
MR
D000268:Adhesiveness; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D016572:Cyclosporine / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D019344:Lactic Acid / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009077:Mucins / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012995:Solubility; D013499:Surface Properties; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
D004337:Drug Carriers; D007166:Immunosuppressive Agents; D009077:Mucins; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D016572:Cyclosporine; D048271:Chitosan