title: Depression after diagnosis of advanced non-small cell lung cancer and survival: a pilot study.
abstract: BACKGROUND
  Major depressive disorder is estimated to occur in 10%-25% of people with cancer, and it has been inconsistently linked to increased mortality.
  
  
  OBJECTIVE
  This pilot study investigates the association of depression and survival in advanced non-small cell lung cancer (NSCLC) patients.
  
  
  METHODS
  Forty-three recently-diagnosed advanced NSCLC patients completed the Hospital Anxiety and Depression Scale and were followed prospectively.
  
  
  RESULTS
  Patients with depression had poorer survival. Median survival was four times shorter than those without depression. Controlling for baseline performance status, depression predicted 6-month mortality, but was not significant for overall survival.
  
  
  CONCLUSIONS
  Although depression after advanced-NSCLC diagnosis was associated with poorer survival at 6 months, this association was not present for overall survival; however, further research with larger samples should be pursued.
authors.affiliation: Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA. wpirl@partners.org
authors.forename: William F
authors.initials: WF
authors.lastname: Pirl
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Temel
authors.forename: Andrew
authors.initials: A
authors.lastname: Billings
authors.forename: Constance
authors.initials: C
authors.lastname: Dahlin
authors.forename: Vicki
authors.initials: V
authors.lastname: Jackson
authors.forename: Holly G
authors.initials: HG
authors.lastname: Prigerson
authors.forename: Joseph
authors.initials: J
authors.lastname: Greer
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lynch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000401:mortality / Q000523:psychology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000209:etiology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010865:Pilot Projects; D011446:Prospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D015996:Survival Rate