[Benign nodular formations of the thyroid gland and changes in cell and humoral immunity before and after surgical treatment].
BACKGROUND
The main trends concerning the volume of surgery in benign thyroid disease - thyroidectomy or organ - preserved surgery, performed in detected immunological disorders, are not well motivated. The AIM of this study was to analyze changes in humoral and cellular immunity in diseases before and after surgical treatment as well as to assess the effects of surgical procedure and to precise its volume.


METHODS
Changes in immune reactivity were investigated in 100 patients. They were selected with nodular (adenomatous) hyperplastic parenchymal processes in the thyroid gland, with or without hyperfunction - euthyroid or Basedowificated nodular goitre, solitary toxic adenoma and nodular form of lymphocytic thyroiditis. Serum anti - thyroglobulin and anti - microsomal antibodies were examined in these patients, and in 56 of them immunophenotypic flowcytometric analyses of peripheral lymphocytes was performed.


RESULTS
Serum antithyroid antibodies gradually decrease in one year after surgery. Pre-surgical changes in lymphocyte subsets number in peripheral blood recovered to great extent. This tendency is best demonstrated in lymphocytic thyreoiditis.


CONCLUSIONS
Study on immune parameters can help to evaluate the positive effect of organ - preserved and at the same time - radical surgical treatment.


CONCLUSIONS
In immune thyroid disorders the organ - preserved radical resection of thyroid gland leaving normal parenchyma is method of choice compared to thyroidectomy since it allows definite treatment with hormonal compensation.
Murdzhev
K
K
Murdzheva
M
M
Uchikov
A
A
Paskalev
G
G
Iankulov
A
A
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood; D005434:Flow Cytometry; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D011446:Prospective Studies; D013961:Thyroid Gland / Q000276:immunology / Q000601:surgery; D016606:Thyroid Nodule / Q000097:blood / Q000276:immunology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome
D001323:Autoantibodies