Sex-dependent hippocampal volume reductions in schizophrenia relate to episodic memory deficits.
Morphological abnormalities of the hippocampus might form the neurobiological basis of memory dysfunction in schizophrenia. Hippocampal volume was found to be bilaterally reduced in male, but not in female, subjects with schizophrenia. Right hippocampal volume was significantly related to impaired visual learning.
Exner
Cornelia
C
Department of Clinical Psychology and Psychotherapy, University of Marburg, Gutenbergstr. 18, D-35032 Marburg, Germany. exnerc@staff.uni-marburg.de
Nehrkorn
Barbara
B
Martin
Vera
V
Huber
Martin
M
Shiratori
Kiyoshi
K
Rief
Winfried
W
D000328:Adult; D000704:Analysis of Variance; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D012727:Sex Characteristics