[Pay close attention to drug-induced lupus].
Drug-induced lupus (DIL) is a lupus-like illness that has been recognized as a side effect of over 80 drugs since its first description in association with sulfadiazine in 1945. The epidemiology and clinical course of idiopathic systemic lupus erythematosus and DIL differ markedly, and prognosis is generally favorable in the latter although occasional life-threatening cases have been reported in the literature. Constant pharmacovigilance is crucial for prompt diagnosis and cessation of offending therapy, hence achieving the best outcome. This review discusses the clinical presentation, diagnosis and treatment of DIL so as to call for vigilance of medical workers.
Zhou
Min-Jie
MJ
Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Ni
Zhao-Hui
ZH
D018501:Antirheumatic Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D013411:Sulfadiazine / Q000009:adverse effects
D018501:Antirheumatic Agents; D004365:Drugs, Chinese Herbal; D013411:Sulfadiazine