Drug loading of nanoporous TiO2 films.
The loading of therapeutic amounts of drug on a nanoporous TiO(2) surface is described. This novel drug-loading scheme on a biocompatible surface, when employed on medical implants, will benefit patients who require the deployment of drug-eluting implants. Anticoagulants, analgesics and antibiotics can be considered on the associated implants for drug delivery during the time of maximal pain or risk for patients undergoing orthopedic procedures. Therefore, this scheme will maximize the chances of patient recovery.
Ayon
Arturo A
AA
MEMS Research Laboratory, Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, TX, USA. aayon@utsa.edu
Cantu
Michael
M
Chava
Kalpana
K
Agrawal
C Mauli
CM
Feldman
Marc D
MD
Johnson
Dave
D
Patel
Devang
D
Marton
Denes
D
Shi
Emily
E
D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D016062:Porosity; D014025:Titanium / Q000737:chemistry*
D001672:Biocompatible Materials; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; C009495:titanium dioxide; D014025:Titanium