Sézary syndrome in a cat.
Sézary syndrome is an uncommon leukemic variant of cutaneous lymphoma in cats. This cat had recurrent dermatitis with erythematous, pruritic plaques. Multiple skin imprints and biopsy samples were obtained over a 6-month period, and histopathological findings were consistent initially with eosinophilic miliary dermatitis and later with erythema multiforme. One week before death, Sézary cells were identified in the peripheral blood that expressed cluster of differentiation (CD)3 and CD8 antigens. Massive infiltration of CD3+ lymphocytes was noted in the skin and multiple internal tissues by histopathological examination. This case demonstrates the difficulty in diagnosing cutaneous lymphoma early in the disease course.
Wood
Casey
C
Department of Diagnostic Medicine, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66506-5705, USA.
Almes
Kelli
K
Bagladi-Swanson
Mary
M
Debey
Brad
B
Andrews
Gordon
G
Nietfeld
Jerome
J
Wilkerson
Melinda
M
D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000473:pathology*; D002415:Cats; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D012751:Sezary Syndrome / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D013601:T-Lymphocytes / Q000473:pathology