title: Myocardial perfusion defects after radiation therapy and anthracycline chemotherapy for left breast cancer: a possible marker of microvascular damage. Three cases and review of the literature.
abstract: Radiation therapy to the thorax may induce early and late cardiac adverse effects if large parts of the heart have been included in the irradiation field and particularly if anthracycline-containing chemotherapy is concomitantly administered. We describe 3 cases of cardiotoxicity in patients with left breast cancer treated with anthracycline-containing chemotherapy and left thoracic radiotherapy. In 2 cases we observed asymptomatic electrocardiographic abnormalities of ventricular repolarization mimicking anterior myocardial ischemia and SPECT reversible myocardial perfusion defects. In 1 case we observed echocardiographic abnormalities of left ventricular wall motion and reversible myocardial perfusion abnormalities. We recommend close cardiac monitoring of patients treated with anthracycline chemotherapy and left thoracic radiotherapy to better understand the clinical impact of these abnormalities.
authors.affiliation: Cardiology Unit, CROB Regional Cancer Hospital, Rionero in Vulture, Potenza, Italy. pina.gallucci@tiscali.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Gallucci
authors.forename: Alba Maria
authors.initials: AM
authors.lastname: Capobianco
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Coccaro
authors.forename: Angela
authors.initials: A
authors.lastname: Venetucci
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Suriano
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fusco
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D015415:Biomarkers; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D003326:Coronary Circulation; D004562:Electrocardiography; D015251:Epirubicin / Q000009:adverse effects*; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000209:etiology*; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000903:Antibiotics, Antineoplastic; D015415:Biomarkers; D015251:Epirubicin