title: Tissue magnesium loss during prolonged hypokinesia in magnesium supplemented and unsupplemented rats.
abstract: This study aims at showing that during hypokinesia (HK) tissue magnesium (Mg2+) content decreases more with higher Mg2+ intake than with lower Mg2+ intake and that Mg2+ loss increases more with higher than lower tissue Mg2+ depletion due to inability of the body to use Mg2+ during HK. Studies were conducted on male Wistar rats during a pre-HK period and a HK period. Rats were equally divided into four groups: unsupplemented vivarium control rats (UVCR), unsupplemented hypokinetic rats (UHKR), supplemented vivarium control rats (SVCR) and supplemented hypokinetic rats (SHKR). SVCR and SHKR consumed 42 mEq Mg2+ per day. The gastrocnemius muscle and right femur bone Mg2+ content decreased significantly, while plasma Mg2+ level and urine and fecal Mg2+ loss increased significantly in SHKR and UHKR compared with their pre-HK values and their respective vivarium controls (SVCR and UVCR). However, muscle and bone Mg2+ content decreased more significantly and plasma Mg2+ level, and urine and fecal Mg2+ loss increased more significantly in SHKR than in UHKR. The greater tissue Mg2+ loss with higher Mg2+ intake and the lower tissue Mg2+ loss with lower Mg2+ intake shows that the risk of higher tissue Mg2+ depletion is directly related to the magnitude of Mg2+ intake. The higher Mg2+ loss with higher tissue Mg2+ depletion and the lower Mg2+ loss with lower Mg2+ tissue depletion shows that the risk of greater Mg2+ loss is directly related to the magnitude of tissue Mg2+ depletion. It was concluded that tissue Mg2+ depletion increases more when the Mg2+ intake is higher and that Mg2+ loss increases more with higher than lower tissue Mg2+ depletion indicating that during prolonged HK the tissue Mg2+ depletion is not due to the Mg2+ shortage in food but to the inability of the body to use Mg2+.
authors.affiliation: Higher Institute of Biochemistry, Gomel, Belarus.
authors.forename: Yan G
authors.initials: YG
authors.lastname: Zorbas
authors.forename: Kostas K
authors.initials: KK
authors.lastname: Kakuris
authors.forename: Viktor A
authors.initials: VA
authors.lastname: Denogradov
authors.forename: Kosmas B
authors.initials: KB
authors.lastname: Yerullis
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D005243:Feces; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D018476:Hypokinesia / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008274:Magnesium / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D008274:Magnesium