title: Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin.
abstract: Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.
authors.affiliation: Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
authors.forename: Frederike
authors.initials: F
authors.lastname: Schirmbeck
authors.forename: Alexander
authors.initials: A
authors.lastname: Georgi
authors.forename: Jana
authors.initials: J
authors.lastname: Strohmaier
authors.forename: Christine
authors.initials: C
authors.lastname: Schmael
authors.forename: Katja V
authors.initials: KV
authors.lastname: Boesshenz
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.forename: Stefan
authors.initials: S
authors.lastname: Herms
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Rami Abou
authors.initials: RA
authors.lastname: Jamra
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D017668:Age of Onset; D002352:Carrier Proteins / Q000235:genetics*; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012917:Social Adjustment
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins