title: IRAK-4 inhibitors. Part 1: a series of amides.
abstract: The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.
authors.affiliation: UCB, Department of Medicinal Chemistry, Granta Park, Great Abington, Cambridge, CB21 6GS, UK.
authors.forename: George M
authors.initials: GM
authors.lastname: Buckley
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Alicia Perez
authors.initials: AP
authors.lastname: Higueruelo
authors.forename: Kerry
authors.initials: K
authors.lastname: Jenkins
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Mack
authors.forename: Trevor
authors.initials: T
authors.lastname: Morgan
authors.forename: David M
authors.initials: DM
authors.lastname: Parry
authors.forename: William R
authors.initials: WR
authors.lastname: Pitt
authors.forename: Oliver
authors.initials: O
authors.lastname: Rausch
authors.forename: Marianna D
authors.initials: MD
authors.lastname: Richard
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Fraser
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D053592:Interleukin-1 Receptor-Associated Kinases / Q000037:antagonists & inhibitors*; D008954:Models, Biological; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D011725:Pyridines; D054852:Small Molecule Libraries; D053592:Interleukin-1 Receptor-Associated Kinases