title: Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy.
abstract: The behavioral effects induced by methamphetamine (5.0 mg/kg) were compared in the mutant mice lacking d-amino acid oxidase activity and normal mice. The mutant mice exhibited marked decline in the methamphetamine-induced stereotypy compared to the normal mice, whereas the mutant mice displayed a drastic augmentation in the locomotor activity evoked by methamphetamine compared to the normal mice. Because the d-serine levels in the brain of the mutant mice are significantly higher than those in the normal mice, the enhanced d-serine in the brain of the mutant mice could antagonize the methamphetamine-induced stereotypy via the N-methyl-d-aspartate receptors.
authors.affiliation: Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259-1143, Japan. hashimot@is.icc.u-tokai.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Konno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yano
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Raita
authors.initials: R
authors.lastname: Tamaki
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003605:D-Amino-Acid Oxidase / Q000172:deficiency* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D018345:Mice, Knockout; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D000697:Central Nervous System Stimulants; D006213:Hallucinogens; D008694:Methamphetamine; D003605:D-Amino-Acid Oxidase