title: Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy.
abstract: Four aromatic medicines (acetaminophen; niacinamide; p-aminophenol; nicotinic acid) containing nitrogen were investigated by FT-NIR (Fourier transform near-infrared) spectroscopy and generalized two-dimensional (2D) correlation spectroscopy. The FT-NIR spectra were measured over a temperature range of 30-130 degrees C. By combining near-infrared spectroscopy, generalized 2D correlation spectroscopy and references, the molecular structures (especially the hydrogen bond related with nitrogen) were analyzed and the NIR band assignments were performed. The results will be helpful to the understanding of aromatic medicines containing nitrogen and the utility of these substances.
authors.affiliation: Department of Pharmacy, Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong, China. liu2112003@hotmail.com
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Gao
authors.forename: Lingbo
authors.initials: L
authors.lastname: Qu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Huang
authors.forename: Bingren
authors.initials: B
authors.lastname: Xiang
mesh_terms: D000082:Acetaminophen / Q000032:analysis; D000577:Amides; D000627:Aminophenols / Q000032:analysis; D006860:Hydrogen Bonding; D008956:Models, Chemical; D015394:Molecular Structure; D009525:Niacin / Q000032:analysis; D009536:Niacinamide / Q000032:analysis; D009584:Nitrogen / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013696:Temperature
chemical_list: D000577:Amides; D000627:Aminophenols; D009536:Niacinamide; D009525:Niacin; D000082:Acetaminophen; D009584:Nitrogen; C026729:4-aminophenol