Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry.
Mouse strains are well-characterized to exhibit differences in their physiological and behavioral responses to nicotine. This report examines the expression of the high-affinity nicotine binding receptor subunit, neuronal nicotinic receptor subunit alpha 4 (nAChR alpha 4), in the dorsal hippocampus of 27 inbred mouse strains. Multiple differences among mouse strains in the cellular expression of nAChR alpha 4 between subregions of the hippocampal field are evident. Differences that we describe in the expression of nAChR alpha 4 suggest mouse strains of diverse genetic origin could exhibit significant variation in how this receptor contributes to modulating intrahippocampal circuitry. These findings define a genetic frame-work in which the strain-specific responses to nicotine include underlying contributions by the varied anatomical context in which nAChRs are expressed.
Gahring
Lorise C
LC
Salt Lake City VA-Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA.
Rogers
Scott W
SW
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008959:Models, Neurological; D018733:Nicotinic Antagonists / Q000378:metabolism; D017966:Pyramidal Cells / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013045:Species Specificity
D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic