The antioxidant properties of serum albumin.
Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical-associated damage is an important factor in many pathological processes. Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant. This review brings together recent insights on albumin antioxidant properties. First, it focuses on the different activities of albumin concerning protein antioxidation. In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported.
Roche
Marjolaine
M
Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, Saint Denis de La Réunion, France.
Rondeau
Philippe
P
Singh
Nihar Ranjan
NR
Tarnus
Evelyne
E
Bourdon
Emmanuel
E
D016166:Free Radical Scavengers / Q000737:chemistry / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D010084:Oxidation-Reduction; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*
D016166:Free Radical Scavengers; D005609:Free Radicals; D008024:Ligands; D012709:Serum Albumin