Adjoint time domain method for fluorescent imaging in turbid media.
Application of adjoint time domain methods to the inverse problem in 3D fluorescence imaging is a novel approach. We demonstrate the feasibility of this approach experimentally on the basis of a time gating technique completely in the time domain by using a small number of time windows. The evolution of the fluorescence energy density function inside a highly scattering cylinder was reconstructed together with optical parameters. Reconstructed energy density was used in localizing two fluorescent tubes. Relatively accurate reconstruction demonstrates the effectiveness and the potential of the proposed technique.
Soloviev
Vadim Y
VY
Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK. v.soloviev@cs.ucl.ac.uk
D'Andrea
Cosimo
C
Brambilla
Marco
M
Valentini
Gianluca
G
Schulz
Ralf B
RB
Cubeddu
Rinaldo
R
Arridge
Simon R
SR
D021621:Imaging, Three-Dimensional; D009391:Nephelometry and Turbidimetry; D055095:Optics and Photonics / Q000295:instrumentation; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D014054:Tomography / Q000295:instrumentation / Q000379:methods