title: Antioxidant activity of diphenylpropionamide derivatives: synthesis, biological evaluation and computational analysis.
abstract: We report the synthesis, antioxidant and antiproliferative activity and a QSAR analysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds was achieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropriate amines using 1-propylphoshonic acid cyclic anhydride (PPAA) as catalyst. Compound structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in LPS stimulated J774.A1 macrophages. All compounds were tested for their effect on viability of cells and results demonstrated that they are not toxic towards the cell lines used. The cytotoxic activity of all compounds was evaluated by a Brine Shrimp Test.
authors.affiliation: Department of Pharmaceutical Sciences, University of Salerno,Via Ponte don Melillo, 84084 Fisciano, (SA) Italy. purbani@unisa.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Urbani
authors.forename: Anna
authors.initials: A
authors.lastname: Ramunno
authors.forename: Rosanna
authors.initials: R
authors.lastname: Filosa
authors.forename: Aldo
authors.initials: A
authors.lastname: Pinto
authors.forename: Ada
authors.initials: A
authors.lastname: Popolo
authors.forename: Erminia
authors.initials: E
authors.lastname: Bianchino
authors.forename: Stefano
authors.initials: S
authors.lastname: Piotto
authors.forename: Carmela
authors.initials: C
authors.lastname: Saturnino
authors.forename: Rocco
authors.initials: R
authors.lastname: De Prisco
authors.forename: Barbara
authors.initials: B
authors.lastname: Nicolaus
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Tommonaro
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D019295:Computational Biology / Q000379:methods*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000577:Amides; D000975:Antioxidants; D008070:Lipopolysaccharides; D011422:Propionates; D017382:Reactive Oxygen Species; D009569:Nitric Oxide