Pyrrolo[2,1-alpha]isoquinoline as a skeleton for the synthesis of bioactive lamellarin H.
Lamellarin H has been shown to be active against the topoisomerase of the Molluscum contagiosum virus (MCV) and to have anti-HIV properties. 1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-2-(2,4,5-trimethoxy-phenyl)-pyrrolo[2,1-alpha] isoquinoline (intermediate 2) is the skeleton for the synthesis of lamellarin H and its derivatives. The synthesis of intermediate 2 is reported here in detail. The intermediate formed is identified by means of IR spectrum, UV spectrum, MS, (1)H NMR, (13)C NMR and melting point measurements.
You
Ye-Cheng
YC
College of Environment and Chemical Engineering, Dalian University, Dalian 116622, People's Republic of China. yycclyy@163.com
Wang
Ai-Ling
AL
Li
De-Peng
DP
Yang
Guang
G
D003374:Coumarins / Q000138:chemical synthesis*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D008422:Materials Testing
D003374:Coumarins; D006576:Heterocyclic Compounds, 4 or More Rings; D007546:Isoquinolines; C455555:lamellarin H