Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function.
Activator of G protein signaling (AGS)-3 plays functional roles in cell division, synaptic plasticity, addictive behavior, and neuronal development. As part of a broad effort to define the extent of functional diversity of AGS3-regulated-events in vivo, we generated AGS3 null mice. Surprisingly, AGS3 null adult mice exhibited unexpected alterations in cardiovascular and metabolic functions without any obvious changes in motor skills, basic behavioral traits, and brain morphology. AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure. AGS3 null mice also exhibited altered blood pressure control mechanisms. These studies expand the functional repertoire for AGS3 and other G protein regulatory proteins providing unexpected mechanisms by which G protein systems may be targeted to influence obesity and cardiovascular function.
Blumer
Joe B
JB
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Lord
Kevin
K
Saunders
Thomas L
TL
Pacchioni
Alejandra
A
Black
Cory
C
Lazartigues
Eric
E
Varner
Kurt J
KJ
Gettys
Thomas W
TW
Lanier
Stephen M
SM
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001823:Body Composition / Q000235:genetics; D001921:Brain / Q000033:anatomy & histology; D019556:COS Cells; D002320:Cardiovascular Physiological Phenomena; D002352:Carrier Proteins / Q000235:genetics* / Q000502:physiology*; D002522:Chlorocebus aethiops; D003433:Crosses, Genetic; D004734:Energy Metabolism / Q000235:genetics; D005260:Female; D020730:Guanine Nucleotide Dissociation Inhibitors; D006706:Homeostasis / Q000235:genetics; D008297:Male; D008660:Metabolism / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000235:genetics; D051381:Rats
D002352:Carrier Proteins; C498915:Gpsm1 protein, mouse; D020730:Guanine Nucleotide Dissociation Inhibitors