Improved synthesis of antibacterial 3-substituted 6-anilinouracils.
3-Substituted 6-anilinouracils, presently the most promising class of inhibitors of the bacterial DNA polymerase in Gram-positive bacteria, have been prepared by a general and straightforward three-step procedure starting from a readily available 1-benzyloxymethyl-protected derivative of 6-chlorouracil.
Svenstrup
Niels
N
Bayer HealthCare AG, Aprather Weg, D-42096 Wuppertal, Germany. NielsSvenstrup@Hotmail.com
Kuhl
Alexander
A
Ehlert
Kerstin
K
Häbich
Dieter
D
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004258:DNA Polymerase III / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D000814:Aniline Compounds; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D014498:Uracil; D004258:DNA Polymerase III