title: Immune surveillance of EBV-infected B cells and the development of non-Hodgkin lymphomas in immunocompromised patients.
abstract: After infection with the Epstein - Barr virus, a common gammaherpes virus which infects and persists in the B cells, an equilibrium is established in which newly infected and differentiating B cells are controlled by cytotoxic T cell (CTL) responses. Disturbance of this equilibrium, which can occur in immunocompromised situations, can lead to uncontrolled lymphoproliferation and subsequent development of non-Hodgkin Lymphomas (NHL). Here, we review the role of immunesurveillance of EBV-infected B cells and two situations where immunesurveillance is altered because of immunodeficiencies, transplantation recipients and HIV infection, which can lead to EBV-mediated NHL. In transplant recipients, immunosuppression prior and during transplantation can lead to lack of immunesurveillance and results in proliferation of infected B cells, which would normally be controlled by CTL responses. Interestingly, in HIV infection both deregulation of the normal B cell biology and a reduction in immunity play a role in developing NHL. Therefore, the nature of EBV infection in HIV-positive subjects is very different from that in transplanted individuals, in whom (re-)appearance of EBV-specific CD8(+) T cells - either by a decrease in immune suppression or infusion of donor lymphocytes - immediately leads to a decrease in EBV load.
authors.affiliation: Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Floor
authors.initials: F
authors.lastname: Pietersma
authors.forename: Erwan
authors.initials: E
authors.lastname: Piriou
authors.forename: Debbie
authors.initials: D
authors.lastname: van Baarle
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007157:Immunologic Surveillance / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology