title: Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.
abstract: Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men.
  
  
  METHODS
  ghrelin (1 microg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.
authors.affiliation: Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci, 14-43100 Parma, Italy. vittorio.coiro@unipr.it
authors.forename: Vittorio
authors.initials: V
authors.lastname: Coiro
authors.forename: Gloria
authors.initials: G
authors.lastname: Saccani-Jotti
authors.forename: Pasquale
authors.initials: P
authors.lastname: Rubino
authors.forename: Guido
authors.initials: G
authors.lastname: Manfredi
authors.forename: Paola
authors.initials: P
authors.lastname: Vacca
authors.forename: Elio
authors.initials: E
authors.lastname: Volta
authors.forename: Paolo
authors.initials: P
authors.lastname: Chiodera
mesh_terms: D000328:Adult; D004347:Drug Interactions / Q000502:physiology; D054439:Ghrelin / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D010121:Oxytocin / Q000494:pharmacology / Q000502:physiology*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D054439:Ghrelin; D009478:Neuropeptide Y; D010121:Oxytocin