title: Proctocolectomy-ileal pouch-anal anastomosis for ulcerative colitis after liver transplantation for primary sclerosing cholangitis: a multi-institutional analysis.
abstract: BACKGROUND
  The association between primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) often mandates their contemporaneous management. Orthotopic liver transplantation (OLTX) has emerged as the only curative therapy for PSC, and total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the definitive treatment for refractory UC. The published experience to date describing IPAA after OLTX has been limited; we sought to examine outcomes associated with proctocolectomy-IPAA after OLTX.
  
  
  METHODS
  We reviewed our multi-institutional experience performing proctocolectomy-IPAA for UC after OLTX for PSC.
  
  
  RESULTS
  Twenty-two patients underwent proctocolectomy-IPAA for UC after OLTX for PSC at four academic medical centers between 1989 and 2006. No perioperative complications or allograft dysfunction were observed. During a median follow-up of 52 months, complications have included transient dehydration (n = 6), chronic pouchitis (n = 2), recurrent PSC (n = 2), small bowel obstruction (n = 2), and pouch-anal anastomotic stricture (n = 1). Median 24-h stool frequency was 5, and fecal continence was reported as satisfactory by all patients.
  
  
  CONCLUSIONS
  This multi-institutional experience suggests that proctocolectomy-IPAA can be performed safely after OLTX. Management strategies should include optimization of small bowel length during pouch and ileostomy construction, vigorous postoperative hydration, early ileostomy closure, and careful monitoring for pouchitis.
authors.affiliation: Department of Surgery, Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-7375, USA. cho@surgery.wisc.edu
authors.forename: Clifford S
authors.initials: CS
authors.lastname: Cho
authors.forename: Merril T
authors.initials: MT
authors.lastname: Dayton
authors.forename: Jon S
authors.initials: JS
authors.lastname: Thompson
authors.forename: Walter A
authors.initials: WA
authors.lastname: Koltun
authors.forename: Charles P
authors.initials: CP
authors.lastname: Heise
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Harms
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery*; D000714:Anastomosis, Surgical / Q000379:methods; D015209:Cholangitis, Sclerosing / Q000601:surgery*; D003093:Colitis, Ulcerative / Q000209:etiology / Q000601:surgery*; D039021:Colonic Pouches; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000379:methods*; D016896:Treatment Outcome