[Role of adipocytokine in bone metabolism].
Growing evidence suggests that positive association between fat mass and bone mineral density (BMD) is mediated not only biomechanical but also biochemical factors. Recent studies on adipocyte function have revealed that adipose tissue is not merely an energy-storing organ but it secretes a variety of biological active molecules, conceptualized as "adipocytokines", including leptin and adiponectin. Adipocyte also exist in bone marrow, and experimental finding indicate the dynamic involvement of adipocytokines in bone metabolism. This report aims to review some of the effects of adipocytokines in bone metabolism, in relation to visceral fat accumulation.
Ebina
Kosuke
K
Osaka University, Graduate School of Medicine, Department of Orthopaedics.
Fukuhara
Atsunori
A
Shimomura
Iichiro
I
D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D052242:Adiponectin / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D015519:Bone Density; D001854:Bone Marrow Cells / Q000166:cytology; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism; D020738:Leptin / Q000378:metabolism / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology
D052242:Adiponectin; D020738:Leptin