Regional variations of low-density lipoprotein oxidizability in hemodialysis patients may explain discrepancies in interventional therapy on oxidative profile.
OBJECTIVE
This study aimed at evaluating oxidative stress (OS) markers (i) in a cross-sectional study of hemodialysis (HD) patients to investigate potential regional effects of these markers and (ii) in a prospective crossover study to evaluate vitamin E-coated membrane (VE) effects.


METHODS
At baseline, OS parameters including low-density lipoprotein (LDL) oxidizability were measured in HD patients from five dialysis facilities. Patients were then randomly assigned to two treatment groups: group I patients (n = 33) switching to VE, and group II patients (n = 29) still using reference polysulfone (PS) membrane. After 3 months, patients were switched from VE to PS and vice versa for 6 months. The same OS parameters were measured after each period.


RESULTS
At baseline, the cross-sectional analysis of LDL oxidizability showed a regional effect. By contrast, the crossover study did not show beneficial effects of VE on this parameter.


CONCLUSIONS
Regional variations of LDL oxidizability in HD patients exist and may explain discrepancies in interventional therapy on OS.
Morena
Marion
M
Laboratoire de Biochimie, Centre Hospitalier Universitaire, Université Montpellier I, Montpellier, France.
Gausson
Valérie
V
Mothu
Nadya
N
Bouchet
Jean-Louis
JL
Chanas
Monique
M
Grandvuillemin
Mireille
M
Robert
Alain
A
Vela
Carlos
C
Canaud
Bernard
B
Cristol
Jean-Paul
JP
Olmer
Michel
M
D000368:Aged; D000596:Amino Acids / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011108:Polymers; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods; D013450:Sulfones; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D000596:Amino Acids; D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D008055:Lipids; D008077:Lipoproteins, LDL; D008567:Membranes, Artificial; D011108:Polymers; D017382:Reactive Oxygen Species; D013450:Sulfones; D014810:Vitamin E; C017662:polysulfone P 1700; D005978:Glutathione