[The role of peroxisome proliferators-activated receptors (PPARgamma) in neoplasms of endocrine glands].
The peroxisome proliferators-activated receptors gamma (PPAR) belong to the family of nuclear receptors, which directly regulate transcription of target genes. PPARgamma take part in many processes such as adipogenesis, glucose and lipid metabolism, atherosclerosis and inflammation and carcinogenesis. The expression of PPARgamma was detected in normal and tumor cells of endocrine glands. Activation of receptors by specific ligands of PPARgamma induces inhibition of cell proliferation, induction of apoptosis and terminal differentiation as well as inhibition of angiogenesis. In the present paper the structure, tissue expression and biological function of PPARgamma are presented. The reports about oncostatic effects of PPARgamma agonists in pituitary adenomas, thyroid cancers and adrenal tumor are reviewed.
Winczyk
Katarzyna
K
Zakład Neuroendokrynologii, Katedra Endokrynologii, Uniwersytet Medyczny, Lodz, Poland. kwinczyk@os1.kappa.pl
D000310:Adrenal Gland Neoplasms / Q000235:genetics*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047495:PPAR gamma / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
D047495:PPAR gamma