title: Default mode network connectivity: effects of age, sex, and analytic approach.
abstract: The 'default mode network' is a set of brain regions showing correlated, low-frequency activity during rest. It includes the posterior cingulate/precuneus, medial prefrontal cortex, and bilateral inferior parietal cortex. Earlier studies have characterized this network using either region of interest-based correlation analyses or data-driven techniques; however, there is some disagreement over which method is superior. We conducted both types of analysis on a large (N=40) data set and also investigated age and sex differences in the network. Both region of interest-based analyses and independent component analysis identified the default mode network. Age and sex differences were small and there was less agreement between analytic techniques regarding age and sex effects than regarding default mode network structure.
authors.affiliation: Department of Psychiatry, Schulich School of Medicine and Dentistry, Canada.
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Bluhm
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Osuch
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Lanius
authors.forename: Kristine
authors.initials: K
authors.lastname: Boksman
authors.forename: Richard W J
authors.initials: RW
authors.lastname: Neufeld
authors.forename: Jean
authors.initials: J
authors.lastname: Théberge
authors.forename: Peter
authors.initials: P
authors.lastname: Williamson
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001931:Brain Mapping; D005260:Female; D006179:Gyrus Cinguli / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D010296:Parietal Lobe / Q000166:cytology* / Q000502:physiology; D017397:Prefrontal Cortex / Q000166:cytology* / Q000502:physiology; D012727:Sex Characteristics; D012737:Sex Factors