HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy.
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P = .01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.
Rauch
Andri
A
Division of Infectious Diseases, University Hospital Bern and University of Bern, Switzerland. andri.rauch@insel.ch
Nolan
David
D
Furrer
Hansjakob
H
McKinnon
Elizabeth
E
John
Mina
M
Mallal
Simon
S
Gaudieri
Silvana
S
Günthard
Huldrych F
HF
Schmid
Patrick
P
Battegay
Manuel
M
Hirschel
Bernard
B
Telenti
Amalio
A
James
Ian
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged
D015235:HLA-B Antigens; C042388:HLA-Bw4 antigen; C038652:HLA-Bw6 antigen