Unilateral cleft lip/palate children: the incidence of type 6 septal deformities in their parents.
BACKGROUND
The overall incidence of pathological septal deformity has been found to be significantly higher in unilateral cleft lip/palate (UCLP) children than in control children. Of the seven types of septal deformity according to Mladina's classification, type 6 has been found to be the most frequent in UCLP children, occurring in only 3.7% of the control children.


OBJECTIVE
To investigate the incidence of type 6 septal deformity in the parents of UCLP children.


METHODS
UCLP children (N=62) and their parents (N=91) were examined for type 6 septal deformities.


RESULTS
Type 6 was found in at least one parent of a UCLP child in 58% of cases. However, it was not found in the parents whose UCLP children did not show a type 6 septal deformity.


CONCLUSIONS
Type 6 septal deformity is almost a rule in children suffering from UCLP. Type 6 was not seen in the parents whose UCLP children did not show a type 6 septal deformity. There is a morphogenetic predisposition for the development of CLP in children whose parents carry a type 6 septal deformity.
Mladina
Ranko
R
Department of Otolaryngology-Head and Neck Surgery, University Hospital Salata, Zagreb, Croatia.
Skitarelić
Neven
N
Vuković
Katarina
K
Subarić
Marin
M
Carić
Tomislav
T
Orihovac
Zeljko
Z
D000293:Adolescent; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D009666:Nose / Q000002:abnormalities*; D010290:Parents; D019655:Quantitative Trait, Heritable