title: Aminobisphosphonates as new weapons for gammadelta T Cell-based immunotherapy of cancer.
abstract: Several observations in mice and in humans have collectively laid the foundation for examining the potential of gammadelta T cells to exert tumor immunotherapy. Human gammaDelta T cells can be activated in a non-MHC dependent fashion either by low molecular mass phosphoantigens, or by agents that provoke the accumulation of endogenous pyrophosphates such as isopentenylpyrophosphate. Among the latter, aminobisphosphonates are well-established in the clinic, and extensive data are available on the compounds' antiangiogenic, antiosteolytic and pro-apoptotic properties. In this review we discuss on the possibility that the intentional activation of gammadelta T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in patients with different types of cancer.
authors.affiliation: Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Corso Tukory 211, Palermo 90134 Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Caccamo
authors.forename: Serena
authors.initials: S
authors.lastname: Meraviglia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cicero
authors.forename: Gaspare
authors.initials: G
authors.lastname: Gulotta
authors.forename: Francesco
authors.initials: F
authors.lastname: Moschella
authors.forename: Adriana
authors.initials: A
authors.lastname: Cordova
authors.forename: Eliana
authors.initials: E
authors.lastname: Gulotta
authors.forename: Alfredo
authors.initials: A
authors.lastname: Salerno
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D045744:Cell Line, Tumor; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D017368:Protein Prenylation; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000187:drug effects* / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D004164:Diphosphonates; D016692:Receptors, Antigen, T-Cell, gamma-delta