Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative and muscle degenerative diseases.
Because bone marrow stromal cells (MSCs) are easily accessible from both healthy donors and patients and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. Benefits of MSCs have been discussed mainly from two aspects: one is their tissue protective and immunomodulatory effects, and the other is their capability under specific manipulations to differentiate into various cell types. In this review, their differentiation into functional neural and muscle cell lineages is the focus, and their potential to the application for tissue reconstruction in neurodegenerative and muscle degenerative diseases is discussed.
Dezawa
Mari
M
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. dezawa@anat2.med.kyoto-u.ac.jp
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D004298:Dopamine / Q000096:biosynthesis; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D024510:Muscle Development; D018485:Muscle Fibers, Skeletal / Q000166:cytology; D009135:Muscular Diseases / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000628:therapy*; D009474:Neurons / Q000166:cytology; D010300:Parkinson Disease / Q000378:metabolism / Q000628:therapy; D012583:Schwann Cells / Q000166:cytology / Q000637:transplantation; D013119:Spinal Cord Injuries / Q000628:therapy; D020521:Stroke / Q000628:therapy; D017154:Stromal Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*
D004298:Dopamine