Cytokine production by human colonic intraepithelial lymphocytes in controls and ulcerative colitis.
Using an ELISA technique, concentrations of gamma-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA). IntraepitheHal lymphocytes produced low concentrations of gamma-interferon and interleukin-2 when stimulated with PHA, but significantly more than when unstimulated (p < 0.05). There was no difference in production of these cytokines by IEL from control or inflammatory bowel disease.
Hoang
P
P
Service de Gastro-Enterologie Université Catholique de Louvain Bruxelles Belgium.
Dalton
H R
HR
de Silv
H J
HJ
Jewell
D P
DP