title: Prodrugs for amines.
abstract: The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A compilation of the most important approaches is presented in the form of a table, where the main advantages and disadvantages of each strategy are also referred.
authors.affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República - EAN, 2780-157 Oeiras, Portugal. anas@itqb.unl.pt
authors.forename: Ana L
authors.initials: AL
authors.lastname: Simplício
authors.forename: John M
authors.initials: JM
authors.lastname: Clancy
authors.forename: John F
authors.initials: JF
authors.lastname: Gilmer
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D004789:Enzyme Activation; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D011355:Prodrugs