title: Predictors of hyperparathyroidism in renal transplant recipients.
abstract: The changes in parathyroid hormone secretion after successful renal transplantation remain to be clearly elucidated. Our study was aimed at identifying the predictors of hyperparathyroidism in renal transplant recipients. A retrospective single center study involving 37 renal transplant recipients, with a follow-up of at least one year, was performed. All transplants were performed using kidneys from living related donors. The average age of the study patients was 30 +/- 10 years, with a male-female ratio of 1.31. The mean duration on hemodialysis (HD) prior to transplantation was 25 +/- 18 months. All the grafts but one, were functional after a mean follow-up of 41 +/- 21 months. We noted a rapid reduction of the mean parathyroid hormone (iPTH) level from 383 +/- 265 pg/ml before transplantation to 125 +/- 67 pg/ml at one year and 108 +/- 66 pg/ml at two years after transplantation (p = 0.01). Bivariate analysis revealed that the level of iPTH obtained during follow-up correlated with the duration on HD (p = 0.03), the serum creatinine at 24-months (p = 0.013), and to the level of iPTH in the first year post-transplantation (p = < 0.001). Other clinical or laboratory parameters were not predictive of hyperparathyroidism after kidney transplantation. Linear regression showed that only the serum creatinine at 24-months independently correlated with the level of iPTH at last follow-up (p = 0.02). Our study suggests that short duration on HD and a functional graft are the main predictors of correction of hyperparathyroidism after renal transplantation.
authors.affiliation: Service de Nephrologie, Dialyse, Transplantation, CHU Ibn Sina, Rabat, Maroc. tariksqalli@hotmail.com
authors.forename: Tarik Sqalli
authors.initials: TS
authors.lastname: Houssaini
authors.forename: Mohamed
authors.initials: M
authors.lastname: Arrayhani
authors.forename: Hakima
authors.initials: H
authors.lastname: Rhou
authors.forename: Yamama
authors.initials: Y
authors.lastname: Amar
authors.forename: Loubna
authors.initials: L
authors.lastname: Benamar
authors.forename: Naima
authors.initials: N
authors.lastname: Ouzeddoun
authors.forename: Rabea
authors.initials: R
authors.lastname: Bayahia
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000453:epidemiology*; D016030:Kidney Transplantation; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies