[Molecular mechanism of switching adipocyte / osteoblast differentiation through regulation of PPAR-gamma function].
Adipocytes and osteoblasts are derived from mesenchymal stem cells, and some adipocyte differentiation regulators suppress osteoblast differentiation. PPAR-gammaplays a pivotal role for adipocyte differentiation and glucose tolerance. PPAR-gammais a member of nuclear receptor super family and regulates mRNA expression level of target genes by binding to fatty acid derivatives and thiazolidinediones. Recently, it was found that PPAR-gammainhibits osteoblast differentiation and regulates bone metabolism. In this report, we show recent studies about the extracellular signals regulating the transactivation function of PPAR-gamma.
Takada
Ichiro
I
The University of Tokyo, Institute of Molecular And Cellular Biosciences, Nuclear signaling.
Kato
Shigeaki
S
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000502:physiology; D002454:Cell Differentiation; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D010006:Osteoblasts / Q000166:cytology*; D047495:PPAR gamma / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*; D015533:Transcriptional Activation; D051153:Wnt Proteins / Q000502:physiology; D000071818:Wnt-5a Protein; D000099151:MAP Kinase Kinase Kinase 7
D048868:Adaptor Proteins, Signal Transducing; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D020930:MAP Kinase Kinase Kinases; D047495:PPAR gamma; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D000099151:MAP Kinase Kinase Kinase 7; C498761:Tab2 protein, mouse; C438615:Wnt5a protein, mouse; C491837:Wnt5a protein, rat