Magnetic resonance imaging in the canine double-haemorrhage subarachnoid haemorrhage model.
In this study, we investigated T2 weighted imaging (T2WI) and T2 values of the cortex, thalamus and cerebrospinal fluid (CSF) of the ventricles in the canine double-haemorrhage subarachnoid haemorrhage (DHSAH) model. T2 values in the cortex increased compared to prescan values from 123.07 +/- 18.72 msec on day 2 to 89.43 +/- 1.98 msec on day 7 (p < 0.05). A trend toward a temporal increase in T2 values was observed in the thalamus, but did not reach significance. The T2 values of the ventricular CSF increased by 102.2% on day 2 and 159.6% on day 7 compared to prescan values. These changes reached significance (p < 0.05) on day 7. Additionally, the ventricular size increased over the study period. Our data suggest that we can use this model to investigate acute brain injury and normal pressure hydrocephalus (NPH) after SAH.
Sugawara
T
T
Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA.
Wang
A
A
Jadhav
V
V
Tsubokawa
T
T
Obenaus
A
A
Zhang
J H
JH
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D008279:Magnetic Resonance Imaging; D013345:Subarachnoid Hemorrhage / Q000235:genetics*; D013788:Thalamus / Q000473:pathology