Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology.
Juvenile idiopathic arthritis (JIA) is a heterogenous childhood disease without reliable biomarkers for monitoring disease progression. Immunoglobulin (Ig) M rheumatoid factor (RF) is used to define a subset of JIA patients, but its significance in JIA is dependent on the method of measurement. In addition to IgM RF, IgA RF has been implicated in determining disease severity in JIA, including functional disability and joint damage. Anticyclic citrullinated peptide (anti-CCP) antibodies have been a valuable diagnostic tool in rheumatoid arthritis, with varied results in their significance in JIA patients. Recent studies have demonstrated the possible usefulness of isotypes of anti-CCP antibodies in monitoring JIA patients to determine disease outcome. Overall, RF isotypes and anti-CCP isotypic antibodies have demonstrated increasing importance in the evaluation of JIA patients to determine which patients may have more aggressive or severe disease and to aid in possible treatment plans to prevent joint damage and disability.
Syed
Reema H
RH
Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Room 211A Doisy Hall, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA.
Gilliam
Brooke E
BE
Moore
Terry L
TL
D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000145:classification / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002648:Child; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000145:classification; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000145:classification* / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D007132:Immunoglobulin Isotypes; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor