Development of calcium silicate/calcium phosphate cement for bone regeneration.
A new type of composite bone cement was prepared and investigated by adding calcium silicate (CS) to calcium phosphate cement (CPC). Low-crystalline CS prepared by heat treatment at low temperature had excellent bioactivity and degradability. Adding CS to CPC did not affect the phase composition and chemical structure of CPC, and had a little effect on the setting time and compressive strength of the composite cement. CS could effectively improve the in vitro and in vivo bioactivity of CPC, and enhance the cell proliferation on the CPC material. The introduction of CS is an effective way to improve the bioactivity and degradability of CPC, which will provide a new strategy to modify CPC.
Guo
Han
H
State Key Laboratory of Bioreactor Engineering, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Wei
Jie
J
Yuan
Yuan
Y
Liu
Changsheng
C
D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D017610:Calcium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019245:Compressive Strength / Q000187:drug effects; D004548:Elasticity / Q000187:drug effects; D006244:Hardness / Q000187:drug effects; D008422:Materials Testing; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D017640:Silicates / Q000737:chemistry* / Q000494:pharmacology*
D001843:Bone Cements; D017610:Calcium Compounds; D002130:Calcium Phosphates; D017640:Silicates; C020243:calcium phosphate; C031293:calcium silicate