title: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman's Disease) as cause of isolated hilar lymphadenopathy and complete remission after high dose steroid.
abstract: Rosai-Dorfman's Disease, also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytic proliferative disorder and a distinct clinico-pathological feature of unknown origin. Painless cervical lymphadenopathy is the most common clinical presentation. Different treatment modalities have been tried with variable responses, however, there is no consensus on the best modality of treatment. Here, we present a case report of SHML causing isolated hilar lymphadenopathy with complete remission for more than 6 years, after a short course of high dose steroid (dexamethasone 20 mg daily for 3 days).
authors.affiliation: Pulmonary Division, King Abdulaziz Medical City, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia. jahdali@yahoo.com
authors.forename: Hamdan H
authors.initials: HH
authors.lastname: Al-Jahdali
authors.forename: Nehad N
authors.initials: NN
authors.lastname: Al-Shirawi
authors.forename: Hana S
authors.initials: HS
authors.lastname: Bamefleh
authors.forename: Nizar M
authors.initials: NM
authors.lastname: Yamani
mesh_terms: D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use*; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone