title: Serotonin transporter gene polymorphisms and sertraline response in major depression patients.
abstract: Major depression (MD) has a complex multifactorial etiology with genetic and environmental factors contributing to the disorder. As with all antidepressant treatments, there is variability in drug response due to heredity, generally focusing on genetic polymorphism of the drug-metabolizing transporter genes. The serotonin transporter (5-HTT) gene is a particularly important candidate for genetic involvement in MD disorders owing to its key role in the regulation of serotonergic transmission and is therefore considered to be an interesting candidate in the mechanism of antidepressant drugs. In this study, we have focused on the associations between genetic polymorphisms in two regions of the 5-HTT gene (5-HTTLPR and VNTR) related to sertraline responses. Our sample consisted of 64 unrelated Turkish subjects who strictly met DSM-IV and CGI scores. There was no significant difference between the frequency of the SS, LS, LL, 9/10, 10/10, 9/12, 10/12, and 12/12 genotypes and responses to sertraline. However, the number of patients can be increased and different drugs can be studied in order to find a specific pharmacogenetic relation.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Dogan
authors.forename: Nevzat
authors.initials: N
authors.lastname: Yuksel
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Ergun
authors.forename: Akin
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Mustafa N
authors.initials: MN
authors.lastname: Ilhan
authors.forename: Hatice Ersin
authors.initials: HE
authors.lastname: Karslioglu
authors.forename: Aysegul
authors.initials: A
authors.lastname: Koc
authors.forename: Adnan
authors.initials: A
authors.lastname: Menevse
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000928:Antidepressive Agents; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline