title: Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia.
abstract: Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter-defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward.
authors.affiliation: University of Amsterdam, Amsterdam. a.a.wilde@amc.uva.nl
authors.forename: Arthur A M
authors.initials: AA
authors.lastname: Wilde
authors.forename: Zahurul A
authors.initials: ZA
authors.lastname: Bhuiyan
authors.forename: Lia
authors.initials: L
authors.lastname: Crotti
authors.forename: Mario
authors.initials: M
authors.lastname: Facchini
authors.forename: Gaetano M
authors.initials: GM
authors.lastname: De Ferrari
authors.forename: Thomas
authors.initials: T
authors.lastname: Paul
authors.forename: Chiara
authors.initials: C
authors.lastname: Ferrandi
authors.forename: Dave R
authors.initials: DR
authors.lastname: Koolbergen
authors.forename: Attilio
authors.initials: A
authors.lastname: Odero
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Schwartz
mesh_terms: D000293:Adolescent; D002395:Catecholamines; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000294:innervation*; D006801:Humans; D008297:Male; D013562:Sympathectomy; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy
chemical_list: D002395:Catecholamines