title: Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats.
abstract: Baicalin is a flavonoid present in many traditional Chinese medicines. A number of studies show that baicalin has anti-inflammatory actions and protects against a variety of tissue and organ injuries. The effect of baicalin in lipopolysaccharide (LPS)-induced acute lung injury is not well studied. In this study, typically acute lung injury was induced in rat by intratracheal injection of LPS, which increased lactate dehydrogenase activity and protein content in bronchoalveolar lavage fluid, wet/dry lung weight ratio, Evan's blue dye leakage, and neutrophil infiltration. Baicalin (20 mg/kg) was administrated 1 hour before or 30 min after LPS injection. Both pre and post-treatment with baicalin attenuated the increase of these parameters and improved histological finding. Our results suggest that baicalin has a therapeutic effect on LPS-induced acute lung injury.
authors.affiliation: Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Kun-Lun
authors.initials: KL
authors.lastname: Huang
authors.forename: Chien-Sheng
authors.initials: CS
authors.lastname: Chen
authors.forename: Ching-Wang
authors.initials: CW
authors.lastname: Hsu
authors.forename: Min-Hui
authors.initials: MH
authors.lastname: Li
authors.forename: Hung
authors.initials: H
authors.lastname: Chang
authors.forename: Shih-Hung
authors.initials: SH
authors.lastname: Tsai
authors.forename: Shi-Jye
authors.initials: SJ
authors.lastname: Chu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006836:Hydro-Lyases / Q000378:metabolism; D008070:Lipopolysaccharides; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D009929:Organ Size; D008517:Phytotherapy; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008070:Lipopolysaccharides; D011506:Proteins; C038044:baicalin; D006836:Hydro-Lyases; C045581:lactate dehydratase