Control of interstitial pneumonia by drip infusion of megadose vitamin C, dehydroepiandrosterone and cortisol. A short review of our experience.
Interstitial pneumonia can be controlled by the combined use of a prophylactic antibiotic system and the drip infusion system including megadose vitamin C, dehydroepiandrosterone (D) and cortisol (F), a fortified substitute of 3 adrenocortical elements. The response of patients was satisfying with few side-effects of F. It was shown that an excess of vitamin C improved the therapeutic efficacy of D-F complex, and that D and F improved the immunodeficient state of the host. The benefit of D as an adrenal androgen in immunology found another example in the combined use of cyclosporine A (CS) and glucocorticoid (G) in the kidney transplantation clinic: CS and G helps improve graft take by creating a state of androgen excess, as testified in both humans and mice--an alleviation of immune conflict.
Kodama
Mitsuo
M
Kodama Research Institute of Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan.
Oyama
Atsushi
A
Takagi
Hiroshi
H
D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D003687:Dehydroepiandrosterone / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000627:therapeutic use; D007262:Infusions, Intravenous; D017563:Lung Diseases, Interstitial / Q000188:drug therapy*
D003687:Dehydroepiandrosterone; D001205:Ascorbic Acid; D006854:Hydrocortisone