Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.
Chambers
John C
JC
Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl., London W2 1PG, UK.
Elliott
Paul
P
Zabaneh
Delilah
D
Zhang
Weihua
W
Li
Yun
Y
Froguel
Philippe
P
Balding
David
D
Scott
James
J
Kooner
Jaspal S
JS
D050154:Adiposity; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006720:Homozygote; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012307:Risk Factors; D049629:Waist-Hip Ratio; D044465:White People
C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4