title: Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe.
abstract: Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).
authors.affiliation: College of Pharmacy, Woosuk University, Samrye, Korea.
authors.forename: Ju Sin
authors.initials: JS
authors.lastname: Kim
authors.forename: Sa Im
authors.initials: SI
authors.lastname: Lee
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Park
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Shin
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Kang-Hyun
authors.initials: KH
authors.lastname: Leem
authors.forename: Mun Yhung
authors.initials: MY
authors.lastname: Jung
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003890:Desiccation; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020939:Zingiber officinale / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D027343:Rhizome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002396:Catechols; D005233:Fatty Alcohols; C040115:shogaol; C007845:gingerol