title: Treatment with pioglitazone induced significant, reversible mitral regurgitation.
abstract: There has in recent years been great concern about possible cardiac side effects of thiazolidinediones (TZDs). We present a case-report of a 60 year-old male who developed significant mitral regurgitation during six months treatment with pioglitazone in parallel with laboratory indications of fluid retention. Echocardiography six months after discontinuation of medication showed regression of mitral regurgitation and the laboratory parameters were also normalized. It is noteworthy that six months treatment with pioglitazone could induce significant valve dysfunction, which was reversible, and this underlines the importance of carefully monitoring patients when placing them on treatment with TZDs.
authors.affiliation: 1Department of Clinical Sciences, Division of Diabetes & Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden.
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Dorkhan
authors.forename: Magnus
authors.initials: M
authors.lastname: Dencker
authors.forename: Anders
authors.initials: A
authors.lastname: Frid
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004452:Echocardiography; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging; D000077205:Pioglitazone; D020127:Recovery of Function; D045162:Thiazolidinediones / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077205:Pioglitazone