Ultrasound, cavitation bubbles and their interaction with cells.
This article reviews the basic physics of ultrasound generation, acoustic field, and both inertial and non-inertial acoustic cavitation in the context of localized gene and drug delivery as well as non-linear oscillation of an encapsulated microbubble and its associated microstreaming and radiation force generated by ultrasound. The ultrasound thermal and mechanical bioeffects and relevant safety issues for in vivo applications are also discussed.
Wu
Junru
J
Department of Physics, Materials Science Program, University of Vermont, Burlington, VT 05405, USA. Jun-ru.wu@uvm.edu
Nyborg
Wesley L
WL
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D016503:Drug Delivery Systems; D004735:Energy Transfer / Q000502:physiology; D006801:Humans; D045423:Microbubbles; D014465:Ultrasonics
D003287:Contrast Media