title: CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.
abstract: To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P trend = 0.003). In haplotype analysis, 462Val-6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk (OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer risk as pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (P interaction = 0.001) and with the GSTM1-null genotype compared with the present type (Pinteraction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer risk in Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea.
authors.forename: Kyoung-Mu
authors.initials: KM
authors.lastname: Lee
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
authors.forename: Margie L
authors.initials: ML
authors.lastname: Clapper
authors.forename: Magnus
authors.initials: M
authors.lastname: Ingelman-Sundberg
authors.forename: Masko
authors.initials: M
authors.lastname: Ono-Kihara
authors.forename: Chikako
authors.initials: C
authors.lastname: Kiyohara
authors.forename: Shen
authors.initials: S
authors.lastname: Min
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Pinpin
authors.initials: P
authors.lastname: Lin
authors.forename: Maria Li
authors.initials: ML
authors.lastname: Lung
authors.forename: Hatice
authors.initials: H
authors.lastname: Pinarbasi
authors.forename: Paola
authors.initials: P
authors.lastname: Pisani
authors.forename: Petcharin
authors.initials: P
authors.lastname: Srivatanakul
authors.forename: Adeline
authors.initials: A
authors.lastname: Seow
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sugimura
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Jun
authors.initials: J
authors.lastname: Yokota
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D019363:Cytochrome P-450 CYP1A1; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D012907:Smoking / Q000009:adverse effects*
chemical_list: D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1