title: Heat stability of chaetoglobosins A and C.
abstract: Chaetomium globosum is commonly found in water-damaged buildings and produces the mycotoxins chaetoglobosin A and chaetoglobosin C (Ch-A and Ch-C, respectively). While attempting to purify Ch-A and Ch-C, we observed that these mycotoxins were broken down after heating. The objective of this study was to determine the temperature and the amount of time necessary to break down Ch-A and Ch-C. We demonstrated that the amounts of Ch-A were significantly reduced when exposed to 75 degrees C for 24 h and 100 degrees C for 90, 120, or 150 min. Under the same conditions, the levels of Ch-C were also lower (although not significantly). At 175 degrees C, no Ch-A was detected after 15 min and Ch-C was significantly reduced after 30 min. Our findings will aid other researchers who work with these mycotoxins in the future.
authors.affiliation: Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Fogle
authors.forename: D R
authors.initials: DR
authors.lastname: Douglas
authors.forename: C A
authors.initials: CA
authors.lastname: Jumper
authors.forename: D C
authors.initials: DC
authors.lastname: Straus
mesh_terms: D002597:Chaetomium / Q000737:chemistry* / Q000378:metabolism; D006358:Hot Temperature; D026121:Indole Alkaloids / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
chemical_list: D026121:Indole Alkaloids; C019290:chaetoglobosins