Catalytic enantioselective addition of diorganozinc reagents to vinyl sulfones.
An efficient method for the catalytic asymmetric conjugate addition of diorganozinc reagents to vinyl sulfones is reported. Using a Binap*Cu complex, enantioselectivities up to 98% ee and high yields can be attained for a variety of substrates. Several dialkylzinc reagents are also compatible with this procedure.
Desrosiers
Jean-Nicolas
JN
Département de Chimie, Université de Montréal, Montréal (Québec), Canada.
Bechara
William S
WS
Charette
André B
AB
D002384:Catalysis; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013450:Sulfones / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D007202:Indicators and Reagents; D009942:Organometallic Compounds; D013450:Sulfones; C009873:divinyl sulfone; D015032:Zinc