Hepatitis B virus genotype A2 harbours an L217R polymorphism which may account for a lower response to adefovir.
Bottecchia
Marcelle
M
Madejón
Antonio
A
Sheldon
Julie
J
García-Samaniego
Javier
J
Barreiro
Pablo
P
Soriano
Vincent
V
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics*; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000821:virology; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D063065:Organophosphonates / Q000494:pharmacology*
D000998:Antiviral Agents; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine