The CAMplexities of central ghrelin.
The gut hormone ghrelin is known to activate hypothalamic AMPK, a crucial metabolic sensor controlling energy balance. In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with acetyl-CoA carboxylase (ACC) in a pathway distinct from the more established AMP/LKB1 pathway.
Sleeman
Mark W
MW
Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. mark.sleeman@regeneron.com
Latres
Esther
E
D000091162:AMP-Activated Protein Kinase Kinases; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D054369:Agouti-Related Protein / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D054439:Ghrelin / Q000378:metabolism*; D007031:Hypothalamus / Q000201:enzymology* / Q000473:pathology; D009478:Neuropeptide Y / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*
D054369:Agouti-Related Protein; C515199:Agrp protein, mouse; D054439:Ghrelin; D009478:Neuropeptide Y; D011494:Protein Kinases; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase; C517700:Camkk2 protein, mouse; D000091162:AMP-Activated Protein Kinase Kinases; D000103:Acetyl-CoA Carboxylase