title: Suicidality in opioid-dependent subjects.
abstract: We determined suicide attempt characteristics in 160 opioid-dependent subjects. Three aspects of suicide vulnerability were also examined: familial aggregation of suicidal behaviors, degree of aggression/impulsivity, and smoking. Forty-eight percent of subjects had a personal history of suicide attempt. A personal history of suicide attempt was associated with an early onset of heroin use, but not with gender differences. A family history of suicide was a progressive risk factor for suicide attempt. Subjects with a personal history of suicide attempt had a higher degree of aggression/impulsivity and smoked more cigarettes. In conclusion, opioid-dependent subjects who attempt suicide show familial aggregation and clinical expressions of suicidal liability similar to those described in other psychiatric groups.
authors.affiliation: Clinical Research and Evaluation Facility, Nathan S. Kline Institute for Psychiatric Research and Rockland Psychiatric Center, Orangeburg, New York, USA.
authors.forename: Fabien
authors.initials: F
authors.lastname: Trémeau
authors.forename: Angélina
authors.initials: A
authors.lastname: Darreye
authors.forename: Luc
authors.initials: L
authors.lastname: Staner
authors.forename: Humberto
authors.initials: H
authors.lastname: Corrêa
authors.forename: Hubert
authors.initials: H
authors.lastname: Weibel
authors.forename: Frédéric
authors.initials: F
authors.lastname: Khidichian
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Macher
mesh_terms: D000328:Adult; D000374:Aggression / Q000523:psychology; D002047:Buprenorphine / Q000627:therapeutic use; D015897:Comorbidity; D003430:Cross-Sectional Studies; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000453:epidemiology / Q000523:psychology; D062787:Drug Overdose / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005602:France; D020022:Genetic Predisposition to Disease / Q000523:psychology; D003932:Heroin / Q000506:poisoning; D006556:Heroin Dependence / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology* / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009294:Narcotics / Q000627:therapeutic use; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology / Q000523:psychology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology / Q000534:rehabilitation; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology* / Q000706:statistics & numerical data*
chemical_list: D009294:Narcotics; D002047:Buprenorphine; D003932:Heroin; D008691:Methadone