Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species.
Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.
Araki
Atsushi
A
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Kubota
Takaaki
T
Tsuda
Masashi
M
Mikami
Yuzuru
Y
Fromont
Jane
J
Kobayashi
Jun'ichi
J
D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism
D000470:Alkaloids; D000890:Anti-Infective Agents; D011758:Pyrroles; C530326:nagelamide K; C530327:nagelamide L