title: Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.
abstract: Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa.
authors.affiliation: Department of Pharmacy, Drug Design and Discovery Center, FUNDP, University of Namur, Namur, Belgium.
authors.forename: Séverine
authors.initials: S
authors.lastname: Robert
authors.forename: Carine
authors.initials: C
authors.lastname: Bertolla
authors.forename: Bernard
authors.initials: B
authors.lastname: Masereel
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dogné
authors.forename: Lionel
authors.initials: L
authors.lastname: Pochet
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015956:Factor XIIa / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000925:Anticoagulants; D003374:Coumarins; D015956:Factor XIIa