Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici.
Pestaloficiols A-E (1-5), five new cyclopropane derivatives, have been isolated from cultures of the plant endophyte Pestalotiopsis fici. The structures of these compounds were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 4 displayed inhibitory effects on HIV-1 replication in C8166 cells.
Liu
Ling
L
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Tian
Renrong
R
Liu
Shuchun
S
Chen
Xulin
X
Guo
Liangdong
L
Che
Yongsheng
Y
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000494:pharmacology*; D010944:Plants / Q000382:microbiology*; D020033:Protein Isoforms / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D003521:Cyclopropanes; D006575:Heterocyclic Compounds, 3-Ring; D020033:Protein Isoforms; D012717:Sesquiterpenes; C529353:pestalotheol C; C430595:pestalotiopsin A; C030797:cyclopropane