title: Carotid artery intima-media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis.
abstract: In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima-media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.
authors.affiliation: Department of Medicine 'B' and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, 52621 Tel Aviv, Israel.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Sherer
authors.forename: Christian
authors.initials: C
authors.lastname: Pagnoux
authors.forename: Gilles
authors.initials: G
authors.lastname: Chironi
authors.forename: Alain
authors.initials: A
authors.lastname: Simon
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
authors.forename: Boris
authors.initials: B
authors.lastname: Gilburd
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D017536:Carotid Artery, Common / Q000473:pathology*; D016022:Case-Control Studies; D018834:Chaperonin 60 / Q000276:immunology; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M; D008077:Lipoproteins, LDL / Q000276:immunology; D008180:Lupus Erythematosus, Systemic; D008297:Male; D008875:Middle Aged; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014657:Vasculitis / Q000276:immunology / Q000473:pathology*; D024101:Mitochondrial Proteins
chemical_list: D001323:Autoantibodies; D018834:Chaperonin 60; D006360:Heat-Shock Proteins; D007075:Immunoglobulin M; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; C060293:HSPD1 protein, human; D024101:Mitochondrial Proteins