Histone modifications: cycling with chromosomal replication.
Histone modifications tend to be lost during chromosome duplication. Several recent studies suggest that the RNA interference pathway becomes active during the weakened transcriptional repression occurring at centromeres in S phase, resulting in the re-establishment of histone modifications that direct the formation of heterochromatin.
Thon
Geneviève
G
Department of Biology, University of Copenhagen, BioCenter, Copenhagen N, Denmark. gen@bio.ku.dk
D004261:DNA Replication / Q000502:physiology*; D006570:Heterochromatin / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D034622:RNA Interference / Q000502:physiology*; D016196:S Phase / Q000502:physiology*; D012568:Schizosaccharomyces
D006570:Heterochromatin; D006657:Histones