title: Prevalence of abnormal glucose metabolism in Chinese renal transplant recipients: a single centre study.
abstract: BACKGROUND
  Post-transplant diabetes mellitus (PTDM) after renal transplantation is associated with adverse outcome on patient and graft survival. Fasting blood glucose alone will underestimate diabetes and also ignores diagnosis of impaired glucose tolerance (IGT). IGT has a strong correlation with diabetes and cardiovascular risk.
  
  
  METHODS
  In this cross-sectional study, we estimate the prevalence of abnormal glucose metabolism (AGM) using oral glucose tolerance test (OGTT) and identify its predictive factors. Patients who received kidney transplantation in our centre without pre-transplant diabetes were recruited. OGTT was performed in patients with fasting glucose levels between 5.6 and 6.9 mmol/L for at least two occasions 6 months post-transplantation.
  
  
  RESULTS
  Of 119 patients recruited, 31 had OGTT performed. The prevalence of PTDM, IGT and IFG was 21.8 (26/119)%, 6.7 (8/119)% and 3.4 (4/119)% respectively. Thus the overall prevalence of AGM was 31.9%. Age (P = 0.003), body mass index (P = 0.032), hepatitis B seropositivity status (P = 0.01), CMV infection (P = 0.02) and acute rejection (P = 0.002) were all associated with development of AGM. Using multivariate analysis, only older age at transplant (OR 1.09), history of acute rejection (OR 3.40) and hepatitis B seropositivity (OR 3.13) were significantly associated with the development of AGM.
  
  
  CONCLUSIONS
  AGM is common in our renal transplant recipients.
authors.affiliation: enal Unit, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, China SAR.
authors.forename: Hoi Wong
authors.initials: HW
authors.lastname: Chan
authors.forename: Chi Yuen
authors.initials: CY
authors.lastname: Cheung
authors.forename: Yan Lun
authors.initials: YL
authors.lastname: Liu
authors.forename: Yiu Han
authors.initials: YH
authors.lastname: Chan
authors.forename: Ho Sing
authors.initials: HS
authors.lastname: Wong
authors.forename: Wai Leung
authors.initials: WL
authors.lastname: Chak
authors.forename: Koon Shing
authors.initials: KS
authors.lastname: Choi
authors.forename: Ka Foon
authors.initials: KF
authors.lastname: Chau
authors.forename: Chun Sang
authors.initials: CS
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D044882:Glucose Metabolism Disorders / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D005947:Glucose