title: Constituents from Hoya parasitica and their cell growth inhibitory activity.
abstract: An androstanoid, hoyasterone (1), a sesquiterpene, 15-bulnesolic acid (2), and a phenolic compound, 1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol (3), together with a known triterpene, dihydrocanaric acid, were isolated from Hoya parasitica. Structures were elucidated by 1 D and 2 D NMR and mass spectroscopic analysis. Among the isolated compounds, only dihydrocanaric acid exhibited growth inhibitory activity against both HeLa and SW480 cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Sadhu
authors.forename: Amina
authors.initials: A
authors.lastname: Khatun
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic