title: Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment.
abstract: Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1-2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.
authors.affiliation: Dept. of Neuro-Oncology, Daniel den Hoed Cancer Center, 5201, 3008AE Rotterdam, The Netherlands.
authors.forename: M C J
authors.initials: MC
authors.lastname: Hanse
authors.forename: M B
authors.initials: MB
authors.lastname: Van't Veer
authors.forename: K
authors.initials: K
authors.lastname: van Lom
authors.forename: M J
authors.initials: MJ
authors.lastname: van den Bent
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001099:Arachnoid / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D015331:Cohort Studies; D015897:Comorbidity; D015140:Dementia, Vascular / Q000209:etiology; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy / Q000556:secondary*; D008578:Meninges / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D008875:Middle Aged; D010841:Pia Mater / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome