title: Allergen inactivation with colloidal silica.
abstract: We evaluated the allergen inactivating effect of colloidal silica by performing enzyme-liked immunosorbent assay (ELISA) whose wells were coated with 150 ng/mL of Japanese cedar pollen allergen (Cry j 1) or mite allergen (Der f 2). The allergens were almost 100% inactivated by 100 microg/mL of colloidal silica having a particle size 5 nm, and the inactivating effect was increased by aluminum binding to the surface of the colloidal silica. The results show that colloidal silica is a promising material for allergen inactivation. Since colloidal silica forms an insoluble nondispersive solid when dried, it is expected that airborne allergens can be reduced by binding them to colloidal silica.
authors.affiliation: Fabric-care Research Laboratories, Research & Development Headquarters, Lion Corporation, Tokyo, Japan. seto@lion.co.jp
authors.forename: Seiichi
authors.initials: S
authors.lastname: Tobe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akimoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Shigematsu
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masazumi
authors.initials: M
authors.lastname: Kikukawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyazawa
mesh_terms: D000485:Allergens / Q000737:chemistry*; D000535:Aluminum / Q000737:chemistry; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000737:chemistry; D052179:Antigens, Plant; D060829:Arthropod Proteins; D002942:Circular Dichroism; D003102:Colloids / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D006454:Hemoglobins / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008925:Mites; D010316:Particle Size; D010940:Plant Proteins / Q000737:chemistry; D011485:Protein Binding; D012822:Silicon Dioxide / Q000737:chemistry*; D013634:Tannins / Q000737:chemistry
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D052179:Antigens, Plant; D060829:Arthropod Proteins; D003102:Colloids; C065290:Cry j I protein, Cryptomeria japonica; C451160:Dermatophagoides farinae antigen f 2; D006454:Hemoglobins; D010940:Plant Proteins; D013634:Tannins; D012822:Silicon Dioxide; D000535:Aluminum