Vitamin D and blood pressure connection: update on epidemiologic, clinical, and mechanistic evidence.
Hypertension is an important risk factor for cardiovascular and kidney disease. High blood pressure is a growing public health problem that is expected to affect 1.6 billion people worldwide by the year 2025. In light of emerging evidence of a widespread global problem of vitamin D deficiency, there has been increasing interest concerning the role of vitamin D in chronic disease. The recent publication of several studies, highlighted in this brief review, supports an association between vitamin D status and blood pressure. It remains to be determined what level of vitamin D status needs to be achieved in different subpopulations to assure the maximum benefit of vitamin D status on blood pressure.
Martini
Ligia A
LA
Nutrition Department, School of Public Health, Sao Paulo University, Sao Paulo, Brazil.
Wood
Richard J
RJ
D019587:Dietary Supplements; D016021:Epidemiologic Studies; D019317:Evidence-Based Medicine; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D014807:Vitamin D / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
D014807:Vitamin D