title: Multifocal Ewing's sarcoma of the brain, calvarium, leptomeninges, spine and other bones in a child.
abstract: Ewing's sarcoma (ES) is a malignant osseous neoplasm that mostly affects children and young male adults, and usually presents as a solitary bony lesion. Multifocal ES of the central nervous system is extremely rare, with an incidence ranging from 1.1% to 4.3%. Clinically, ES may mimic osteomyelitis. In this report, we describe the case of an 11-year-old boy who had multiple calvarial, leptomeningeal, spinal and various other bony lesions of ES, which were diagnosed radiologically and histopathologically. To the best of our knowledge, this is the first time that multiple brain, calvarial and spinal lesions of ES in a single patient have been reported in the English-language literature. We discuss possible mechanisms and differential diagnoses for this rare pathology.
authors.affiliation: Department of Neurosurgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey.
authors.forename: Aslan
authors.initials: A
authors.lastname: Güzel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tatli
authors.forename: Uygur
authors.initials: U
authors.lastname: Er
authors.forename: Fahri
authors.initials: F
authors.lastname: Yilmaz
authors.forename: Murad
authors.initials: M
authors.lastname: Bavbek
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000473:pathology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000556:secondary*; D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000556:secondary*; D008578:Meninges / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology; D010019:Osteomyelitis / Q000175:diagnosis; D011859:Radiography; D012512:Sarcoma, Ewing / Q000556:secondary*; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology; D012888:Skull Neoplasms / Q000556:secondary*; D013125:Spinal Neoplasms / Q000556:secondary*; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology; D013628:Talus / Q000000981:diagnostic imaging / Q000473:pathology; D016896:Treatment Outcome