New tricks for old NODs.
Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and the questions and implications they raise regarding the function of NOD-like receptors in the antiviral response.
Pietras
Eric M
EM
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Cheng
Genhong
G
D006801:Humans; D007109:Immunity; D007370:Interferon Type I / Q000096:biosynthesis*; D024101:Mitochondrial Proteins / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction; D014780:Viruses / Q000276:immunology
D007370:Interferon Type I; D024101:Mitochondrial Proteins; C527006:NLRX1 protein, human