title: Aluminosilicates and biphasic HA-TCP composites: studies of properties for bony filling.
abstract: Aluminosilicate materials synthesized at room temperature present good mechanical properties. Hydroxyapatite, tricalcium phosphate or both offer a high biocompatibility in the biomedical field. In this work, we focused on the composites resulting from associations of these materials. The best compromise between porosity and biomechanical properties versus different parameters was determined. The in vitro behaviour of compounds in contact with the simulated body fluid (SBF) was studied and in vivo experiments in a rabbit's thighbones were carried out. The inductively coupled plasma-optical emission spectroscopy (ICP-OES) method permitted us to study the eventual release of Al from composites to SBF and to evaluate the chemical stability of composites characterized by the succession of SiO(4) and AlO(4) tetrahedra. The kinetic biomineralization, the bioconsolidation and biological studies were made. The results obtained show the chemical stability of composites. In the bone-implant interface, the intimate links reveal the high quality of the biointegration and the bioconsolidation between composites and bony matrix. Histological studies confirm good bony bonding and highlight the total absence of inflammation or fibrous tissues.
authors.affiliation: Université de Rennes1, UMR-CNRS 6226, Campus de Beaulieu, 263 avenue Général Leclerc, 35042 Rennes, France. hassane.oudadesse@univ-rennes1.fr
authors.forename: H
authors.initials: H
authors.lastname: Oudadesse
authors.forename: A C
authors.initials: AC
authors.lastname: Derrien
authors.forename: M
authors.initials: M
authors.lastname: Mami
authors.forename: S
authors.initials: S
authors.lastname: Martin
authors.forename: G
authors.initials: G
authors.lastname: Cathelineau
authors.forename: L
authors.initials: L
authors.lastname: Yahia
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D019245:Compressive Strength; D004548:Elasticity; D005264:Femoral Fractures / Q000473:pathology* / Q000628:therapy*; D005898:Glass / Q000737:chemistry*; D006882:Hydroxyapatites / Q000737:chemistry* / Q000627:therapeutic use*; D008422:Materials Testing; D044367:Phase Transition; D016062:Porosity; D011817:Rabbits; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000538:Aluminum Silicates; D018786:Bone Substitutes; D006882:Hydroxyapatites; C070637:hydroxyapatite-glass-titanium composite; C049037:aluminosilicate; D014025:Titanium