title: Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats.
abstract: Eight cases of glomerular disease in young, related Abyssinian cats are described. Haematuria was the most consistent feature. Six cats developed the nephrotic syndrome. The short-term prognosis was good for cats with haematuria and fair for cats with the nephrotic syndrome as oedema resolved in three of the six cats. Light microscopic examination of renal biopsies from three cats was considered normal or revealed only mild abnormalities. In the three cases subjected to necropsy, histological abnormalities included mild mesangial hypercellularity and adhesions between the glomerular tuft and Bowman's capsule consistent with a focal proliferative glomerulopathy. Further investigation into this glomerulopathy will require ultrastructural and immunohistochemical studies to characterise the glomerular abnormality and genetic analyses to investigate its potential to be an inherited disease. Glomerular disease, potentially a familial one, should be considered in the investigation of persistent haematuria or proteinuria in Abyssinian and related cats.
authors.affiliation: Faculty of Veterinary Science, The University of Sydney, NSW, Australia. joannaw@vetc.usyd.edu.au
authors.forename: Joanna D
authors.initials: JD
authors.lastname: White
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Norris
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Bosward
authors.forename: R
authors.initials: R
authors.lastname: Fleay
authors.forename: Chris
authors.initials: C
authors.lastname: Lauer
authors.forename: Richard
authors.initials: R
authors.lastname: Malik
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats / Q000145:classification*; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000662:veterinary*; D006417:Hematuria / Q000209:etiology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000209:etiology / Q000662:veterinary*; D013045:Species Specificity