title: An efficient synthesis of gamma-amino acids and attempts to drive its enantioselectivity.
abstract: Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding gamma-cyanoacids, which on hydrogenation yielded gamma-amino acids. This two step methodology improves upon previously described results. Poor e.e's resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amide induction.
authors.affiliation: Department de Organic Chemistry, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Gil
authors.forename: Margarita
authors.initials: M
authors.lastname: Parra
authors.forename: Pablo
authors.initials: P
authors.lastname: Rodríguez
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000097:Acetonitriles; D000577:Amides; D000596:Amino Acids; D002264:Carboxylic Acids; D010648:Phenylacetates; C025136:phenylacetic acid; C032159:acetonitrile