title: Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex.
abstract: We studied the effect of prostaglandins on presynaptic NMDA receptors. Prostaglandin E2 inhibited NMDA-induced (45)Ca2+ uptake by synaptosomes in low concentrations (IC50 approximately 10 microM), but potentiated it in higher concentrations. Prostaglandin D2 increased (45)Ca2+ uptake by synaptosomes during stimulation of NMDA receptors. Our results indicate that prostaglandins D2 and E2 modulate function of presynaptic NMDA receptors.
authors.affiliation: Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chemogolovka. plv@icp.ac.ru
authors.forename: L N
authors.initials: LN
authors.lastname: Petrova
authors.forename: A V
authors.initials: AV
authors.lastname: Gabrelian
authors.forename: I V
authors.initials: IV
authors.lastname: Serkov
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D015232:Dinoprostone; D015230:Prostaglandin D2; D002118:Calcium