Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury.
This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to "carbonyl stress" during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.
Burcham
P C
PC
Pharmacology & Anaesthesiology Unit, School of Medicine & Pharmacology, The University of Western Australia, Nedlands, WA, Australia. philip.burcham@uwa.edu.au
Kaminskas
L M
LM
Tan
D
D
Pyke
S M
SM
D000171:Acrolein / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced / Q000188:drug therapy; D016923:Cell Death / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013119:Spinal Cord Injuries / Q000139:chemically induced / Q000188:drug therapy
D016166:Free Radical Scavengers; D020011:Protective Agents; D006830:Hydralazine; D000171:Acrolein