Plasma myeloperoxidase is related to the severity of coronary artery disease.
OBJECTIVE
It has been shown that the main apolipoprotein of HDL, Apo A-1, is subjected to nitration by myeloperoxidase (MPO) and this oxidative modification renders HDL proatherogenic. The aim of this study is to evaluate the relationship between plasma MPO levels, and the severity of coronary artery disease.


RESULTS
Forty-eight patients with coronary artery narrowing and 30 control subjects were enrolled in this study. The severity of the disease was assessed by Gensini scoring after angiography. MPO concentrations were determined by using an enzyme immunoassay. A subgroup of 30 patients underwent computerized tomography to determine the calcium load of coronary arteries. Plasma MPO levels were found significantly higher in patients with coronary artery disease than controls (4.27 [1.60 to 42.43] ng/mL vs. 2.93 [1.00 to 9.25] ng/mL, P = 0.002). MPO was positively correlated with both Gensini (r = 0.228, P = 0.044) and coronary calcium scores (r = 0.433, P = 0.017). The atherosclerotic burden was more strongly correlated with MPO levels than the traditional markers such as total cholesterol and HDL.


CONCLUSIONS
We found that MPO levels were elevated in patients with coronary artery disease and this increase correlated with the extent and severity of atherosclerosis. Although it is a preliminary study with a relatively small group of subjects, we suggest that MPO might be evaluated as a new marker indicating the presence and severity of coronary artery disease.
Düzgünçinar
Ovünç
O
Department of Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Yavuz
Bünyamin
B
Hazirolan
Tuncay
T
Deniz
Ali
A
Tokgözoğlu
S Lale
SL
Akata
Deniz
D
Demirpençe
Ediz
E
D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000378:metabolism; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D011379:Prognosis; D012720:Severity of Illness Index; D036542:Tomography, Spiral Computed
D015415:Biomarkers; D009195:Peroxidase; D002118:Calcium