Annexin V expression in human placenta is influenced by the carriership of the common haplotype M2.
In a group of placentas from patients with preeclampsia or fetal growth restriction, reduced annexin V gene expression in those carrying the M2 haplotype was observed. This is the first "ex vivo" demonstration that annexin V gene expression in placentas is dependent on the M2 haplotype.
Chinni
Elena
E
Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S Giovanni R, Foggia, Italy. celine.chalas@cch.aphp.fr
Tiscia
Giovanni Luca
GL
Colaizzo
Donatella
D
Vergura
Patrizia
P
Margaglione
Maurizio
M
Grandone
Elvira
E
D017304:Annexin A5 / Q000235:genetics*; D016022:Case-Control Studies; D015536:Down-Regulation; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017304:Annexin A5; D012333:RNA, Messenger