Continuous intra-arterial nimodipine for the treatment of cerebral vasospasm.
Two patients with refractory symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) were treated by continuous intra-arterial nimodipine infusion via a catheter placed in the internal carotid artery or vertebral artery for 3 and 12 days, respectively. Recovery of the neurological deficits, normalization of MR perfusion, a decrease in the elevated mean flow velocity measured by transcranial duplex sonography, and angiographic recanalization were observed. Continuous intra-arterial nimodipine might be a treatment option in severe refractory vasospasm following SAH.
Mayer
Thomas E
TE
Department of Neuroradiology, University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, Jena 07747, Germany. t.e.mayer@med.uni-jena.de
Dichgans
Martin
M
Straube
Andreas
A
Birnbaum
Tobias
T
Müller-Schunk
Stephanie
S
Hamann
Gerhard F
GF
Schulte-Altedorneburg
Gernot
G
D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*
D014665:Vasodilator Agents; D009553:Nimodipine