title: Is there any relationship between metabolic parameters and left ventricular functions in type 2 diabetic patients without evident heart disease?
abstract: BACKGROUND
  The aim of the present study was to evaluate left ventricle (LV) systolic and diastolic function, using tissue Doppler echocardiography (TDE) and color M-mode flow propagation velocity, in relation to blood glucose status in normotensive patients with type 2 diabetes mellitus (T2DM) who had no clinical evidence of heart disease.
  
  
  METHODS
  Seventy-two patients with T2DM (mean age 49.1 +/- 9.8 years) without symptoms, signs or history of heart disease and hypertension, and 50 ages matched healthy controls (mean age 46.1 +/- 9.8 years) had echocardiography. Systolic and diastolic LV functions were detected by using conventional echocardiography, TDE and mitral color M-mode flow propagation velocity (V(E)). Fasting blood glucose level (FBG) after 8 hours since eating a meal, postprandial blood glucose level (PPG), and HbA(1C) level were determined. The association of FBG, PPG and HbA(1C) with the echocardiographic parameters was investigated.
  
  
  RESULTS
  It was detected that although systolic functions of two groups were similar, diastolic functions were significantly impaired in diabetics. No relation of FBG and PPG with systolic and diastolic functions was determined. However, HbA(1C) was found to be related to diastolic parameters such as E/A, Em/Am, V(E) and E/V(E) (beta=-0.314, P = < 0.05; beta=-0.230, P < 0.05; beta=-0.602, P < 0.001, beta= 0.387, P < 0.005, respectively). In addition to HbA(1C), LV, diastolic functions were also correlated with age and diabetes duration.
  
  
  CONCLUSIONS
  Diastolic LV dysfunction may develop even in absence of ischemia, hypertension, and LVH in T2DM. FBG and PPG have no effect on LV functions, but HbA(1C) levels may affect diastolic parameters.
authors.affiliation: Department of Cardiology, Selcuk University, Medical Faculty, Konya, Turkey. myazici61@hotmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
authors.forename: Kurtulus
authors.initials: K
authors.lastname: Ozdemir
authors.forename: Mustafa Sait
authors.initials: MS
authors.lastname: Gonen
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kayrak
authors.forename: Mehmet Siddik
authors.initials: MS
authors.lastname: Ulgen
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Duzenli
authors.forename: Raziye
authors.initials: R
authors.lastname: Yazici
authors.forename: Ahmet
authors.initials: A
authors.lastname: Soylu
authors.forename: Hasan
authors.initials: H
authors.lastname: Gok
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging* / Q000378:metabolism*; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011336:Probability; D012016:Reference Values; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D001786:Blood Glucose