title: On the Mechanism of Action of the Antitumor Drug cis-Platin (cis-DDP) and its Second Generation Derivatives.
abstract: The present article attempts to summarise the elements of the mechanism of action of the antitumor drug cis -Platin presented the last few years. Highlights on the discovery, of the drug and the development of it's second generation derivatives are presented, as well as the ways that cis -DDP reacts with biomolecules as DNA and proteins and their models e.g. nucleosides, nucleotides. Also the hydrolysis data are presented for cis -DDP and its' inactive congener trans -DDP, as well as for the second generation drug carboplatin. Finally, usefull conclusions are given from this work, pointing out the unanswered questions about the action of cis -DDP as well as its differences in action, in comparison with trans -DDP.
authors.affiliation: University of Ioannina Department of Chemistry Laboratory of Inorganic and General Chemistry Ioannina 45-110 Greece.
authors.forename: V
authors.initials: V
authors.lastname: Aletras
authors.forename: D
authors.initials: D
authors.lastname: Hadjiliadis
authors.forename: N
authors.initials: N
authors.lastname: Hadjiliadis