title: Newly developed signal-averaged vector-projected 187-channel electrocardiogram can evaluate the spatial distribution of repolarization heterogeneity.
abstract: The purpose of this study was to verify the spatial distribution of myocardial repolarization heterogeneity using a newly developed 187-channel signal-averaged vector-projected ECG (187-ch SAVP-ECG). We constructed corrected recovery time (RTc) and Tpeak-end (corrected Tp-e) dispersion maps using a 187-ch SAVP-ECG based on vector-projection theory using a Mason-Likar lead system. We compared the spatial distribution and quantitative values of dispersion maps by 187-ch SAVP-ECG with those by 64-ch magnetocardiography (MCG) in 27 normal controls (control) and 16 patients (12 myocardial infarction (MI), and 4 dilated cardiomyopathy (DCM)). The wave pattern of the 187-ch SAVP-ECG in the representative cases was similar to those in 64-ch MCG. Spatial distribution increased RTc and corrected Tp-e dispersion maps defined by 187-ch SAVP-ECG were in agreement with those by 64-ch MCG. The value of RTc dispersion in MI was higher than that in control (41 +/- 21 ms in MI versus 30 +/- 12 ms in control, P < 0.05). The value of corrected Tp-e dispersion in DCM was higher than that in control (58 +/- 12 ms in DCM versus 30 +/- 13 ms in control, P < 0.001). There was a good correlation between RTc and corrected Tp-e dispersion values determined by 187-ch SAVP-ECG and 64-ch MCG modalities (y = 0.46x + 18, r = 0.62, P = 0.02 for RTc dispersion; y = 0.52x + 15, r = 0.63, P = 0.01 for corrected Tp-e dispersion). RTc and corrected Tp-e dispersion maps by 187-ch SAVP-ECG based on vector-projection theory can evaluate the spatial distribution of myocardial repolarization heterogeneity.
authors.affiliation: Department of Laboratory Medicine, Iwate Medical University, Iwate, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakai
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Miyake
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kasanuki
authors.forename: Morio
authors.initials: M
authors.lastname: Shoda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Futagawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Matsuyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Nirei
authors.forename: Junichi
authors.initials: J
authors.lastname: Tsuboi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okabayashi
authors.forename: Manabu
authors.initials: M
authors.lastname: Itoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawata
mesh_terms: D000368:Aged; D018780:Body Surface Potential Mapping / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008564:Membrane Potentials; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D009206:Myocardium