title: Impact of pulsatile perfusion on postoperative outcome of kidneys from controlled donors after cardiac death.
abstract: Pulsatile perfusion (PP) might be a cost-effective cold preservation technique to reduce the incidence of delayed graft function (DGF) in kidneys from deceased donors. With the aim to address whether PP can reduce the incidence of DGF in kidneys from controlled donors after cardiac death (cDCD), we compared the clinical outcome of 30 recipients of kidneys from cDCD preserved by static cold storage (cDCD-SCS) with 30 recipients of cDCD kidneys preserved by PP (cDCD-PP). The end-points were the incidence of primary nonfunction (PNF), DGF and acute rejection (AR), the length of hospitalization, 1, 3, 6 and 12-months graft function, graft survival and patient survival. Donor, recipient and preimplantation data were well matched. DGF was significantly lower (53.3% vs. 86.6% P<0.001) and the length of hospitalization shorter (10 vs. 14 days P<0.033) in the cDCD-PP group. Similarly, postoperative and short-term graft function (7 and 30 days and 6 and 12 months, respectively) was statistically better in the cDCD-PP than in the cDCD-SCS. In summary, in this cohort, clinical introduction of PP was associated with a significant reduction of DGF, shorter hospitalization and better graft function than SCS.
authors.affiliation: Nuffield Department of Surgery, University of Oxford, Oxford Transplant Centre, Churchill Hospital, Oxford, UK. juan.plata-munoz@nds.ox.ac.uk
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Plata-Munoz
authors.forename: Anand
authors.initials: A
authors.lastname: Muthusamy
authors.forename: Isabel
authors.initials: I
authors.lastname: Quiroga
authors.forename: Harold H
authors.initials: HH
authors.lastname: Contractor
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sinha
authors.forename: Anil
authors.initials: A
authors.lastname: Vaidya
authors.forename: Christopher
authors.initials: C
authors.lastname: Darby
authors.forename: Susan V
authors.initials: SV
authors.lastname: Fuggle
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Friend
mesh_terms: D000293:Adolescent; D000328:Adult; D051799:Delayed Graft Function / Q000517:prevention & control*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D011673:Pulsatile Flow