title: A different TIPE of immune homeostasis.
abstract: Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.
authors.affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Freundt
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bidere
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lenardo
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism; D016923:Cell Death; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C529002:TIPE2 protein, mouse; D051193:Toll-Like Receptors; D020169:Caspases