title: Boosting controlled autoimmunity: a new therapeutic target for CNS disorders.
abstract: In most tissues, the immune system plays an essential role in protection, repair and healing. Although immunologically privileged, the CNS remains subject to a highly regulated form of immunosurveillance that is of increasing interest. There is evolving evidence that repair mechanisms within the CNS may be enhanced by exploiting an innate process of protective immunity. Understanding the regulation of protective autoimmunity within the CNS is likely to lead to novel therapeutic approaches to neuroinflammatory and neurodegenerative diseases.
authors.affiliation: Center for Genetic Engineering & Biotechnology, Avenue 31 e/158 & 190, PO Box 6162, Cubancan, Playa 10600, Havana City, Cuba. diana.garcia@cigb.edu.cu
authors.forename: Diana García
authors.initials: DG
authors.lastname: del Barco
authors.forename: Jorge
authors.initials: J
authors.lastname: Berlanga
authors.forename: Eduardo
authors.initials: E
authors.lastname: Penton
authors.forename: Orla
authors.initials: O
authors.lastname: Hardiman
authors.forename: Enrique
authors.initials: E
authors.lastname: Montero
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology*; D001921:Brain / Q000187:drug effects* / Q000276:immunology*; D001927:Brain Diseases / Q000276:immunology* / Q000517:prevention & control*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D018448:Models, Immunological; D018696:Neuroprotective Agents / Q000276:immunology* / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents