title: Overall survival in women with breast cancer: the influence of pepsinogen C gene polymorphism.
abstract: We aimed to study the role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients. The six polymorphic alleles were amplified using PCR. Our results indicate that patients carrying the allele 6 present a higher 5-year survival mean (83.4% of 6 allele carriers were alive at 5 years vs. only 68.6% of noncarriers, p=0.001), suggesting a role for this polymorphism in the outcome of breast cancer patients. We hypothesize that PGC polymorphism can be a predictive biomarker in breast cancer, contributing to an individual profile of great interest in clinical oncology.
authors.affiliation: Molecular Oncology Group, Portuguese Institute of Oncology, Porto, Portugal.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Pinto-Correia
authors.forename: Daniela
authors.initials: D
authors.lastname: Pinto
authors.forename: Deolinda
authors.initials: D
authors.lastname: Pereira
authors.forename: Helena
authors.initials: H
authors.lastname: Rodrigues
authors.forename: Joaquim Abreu
authors.initials: JA
authors.lastname: de Sousa
authors.forename: Hugo
authors.initials: H
authors.lastname: Sousa
authors.forename: Berta
authors.initials: B
authors.lastname: Sousa
authors.forename: Susana
authors.initials: S
authors.lastname: Sousa
authors.forename: Carlos
authors.initials: C
authors.lastname: Lopes
authors.forename: Rui
authors.initials: R
authors.lastname: Medeiros
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000401:mortality; D017931:DNA Primers / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016254:Mutagenesis, Insertional; D020115:Pepsinogen C / Q000235:genetics*; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D011379:Prognosis; D017384:Sequence Deletion
chemical_list: D014408:Biomarkers, Tumor; D017931:DNA Primers; D004273:DNA, Neoplasm; D020115:Pepsinogen C