title: Low adiponectin levels in primary hypertriglyceridemic male patients.
abstract: OBJECTIVE
  Adiponectin is an adipokine highly and specifically expressed by adipose cells with antiatherogenic and antiinflammatory activities. The aim of the present study was to evaluate plasma adiponectin concentration in patients with primary hypertriglyceridemia and its relationship with metabolic parameters.
  
  
  RESULTS
  Male patients with primary hypertriglyceridemia and without the metabolic syndrome (n=22) were compared with normotriglyceridemic individuals (n=25). Plasma adiponectin concentration was measured by standardised enzyme-linked immunosorbent assay. Body mass index, waist circumference, glucose, insulin and non-esterified fatty acid levels, lipoprotein profile, and CETP activity were evaluated. Adiponectin levels were significantly decreased in hypertriglyceridemic patients in comparison with normotriglyceridemic subjects (4292+/-1717 vs. 6939+/-3249 ng/ml, p<0.005, respectively). Adiponectin was negatively associated with glucose (r=-0.44, p<0.01), insulin (r=-0.37, p<0.01), HOMA (r=-0.40, p<0.01), triglycerides (r=-0.36, p<0.01), VLDL-C (r=-0.34, p<0.05), and CETP (r=-0.47, p<0.001). Positive and significant correlations were observed with QUICKI (r=0.49, p<0.001) and HDL-C (r=0.33, p<0.05). In the multiple linear regression analysis, considering waist circumference, QUICKI, Log-triglycerides, HDL-C, and CETP as independent variables, Log-adiponectin showed a positive correlation with QUICKI, with an r(2)=0.229 and p<0.001. Therefore, the independent variable QUICKI explained the 23% of the variance in Log-adiponectin concentration.
  
  
  CONCLUSIONS
  We found low adiponectin levels in a population of primary hypertriglyceridemic men without the metabolic syndrome and an independent relationship between adiponectin concentration and insulin resistance. A reduction in insulin sensitivity and its impact on adiponectin concentration could be linked to high non-esterified fatty acid levels, increased triglyceride synthesis in the liver and impaired catabolism of triglyceride-rich lipoproteins.
authors.affiliation: Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, Institute of Physiopathology and Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Gómez Rosso
authors.forename: T
authors.initials: T
authors.lastname: Meroño
authors.forename: M B
authors.initials: MB
authors.lastname: Benítez
authors.forename: G
authors.initials: G
authors.lastname: López
authors.forename: G
authors.initials: G
authors.lastname: Giunta
authors.forename: M L
authors.initials: ML
authors.lastname: D'Ambrosio
authors.forename: R
authors.initials: R
authors.lastname: Wikinski
authors.forename: L
authors.initials: L
authors.lastname: Cuniberti
authors.forename: F
authors.initials: F
authors.lastname: Brites
mesh_terms: D052242:Adiponectin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood; D015536:Down-Regulation; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008074:Lipoproteins / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides