title: Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism.
abstract: Heme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. The HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (<27 repeats) and long repeats (L) (>/=27 repeats). A total of 47.5% of the donors carried the S allele. The allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. For the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN.
authors.affiliation: Nephrology Division, Universidade Federal de Säo Paulo, Brazil.
authors.forename: K S
authors.initials: KS
authors.lastname: Ozaki
authors.forename: G M
authors.initials: GM
authors.lastname: Marques
authors.forename: E
authors.initials: E
authors.lastname: Nogueira
authors.forename: R Q
authors.initials: RQ
authors.lastname: Feitoza
authors.forename: M A
authors.initials: MA
authors.lastname: Cenedeze
authors.forename: M F
authors.initials: MF
authors.lastname: Franco
authors.forename: M
authors.initials: M
authors.lastname: Mazzali
authors.forename: M P
authors.initials: MP
authors.lastname: Soares
authors.forename: A
authors.initials: A
authors.lastname: Pacheco-Silva
authors.forename: N O S
authors.initials: NO
authors.lastname: Câmara
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018900:Dinucleotide Repeats / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006085:Graft Survival / Q000235:genetics*; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D051547:Heme Oxygenase-1