title: Monoindole alkaloids from a marine sponge Spongosorites sp.
abstract: Seven (1-7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1-5 are unique indole pyruvic acid derivatives. Compounds 1-2 and 4-6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea. baorchon@yahoo.com
authors.forename: Baoquan
authors.initials: B
authors.lastname: Bao
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Yoonmi
authors.initials: Y
authors.lastname: Lee
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung