title: [Features of Krukenberg-type tumors--clinical study and review].
abstract: Krukenberg-type tumors (KT) are rare among ovarian metastases, but responsible for the most frequent diagnostic confusions with ovarian cancer. They are peculiar: uncertain pathogenesis, challenging etiological diagnosis, poorer prognosis for the primary. We studied 9 cases, with a mean age of 52 years, operated since 2001; no case was discovered as a result of prophylactic oophorectomy. Timing of TK diagnosis: 3--metachronous, 4--synchronous, as incidental discovery and 2--retrospective pathological diagnosis. Site of primary: 3--gastric, 5--colonic or appendiceal, 1--breast. Imaging appearance was useful only if interpreted in clinical conditions. Morphology: 7/9 bilateral, solid or mixed gross appearance, oval, mean diameters 9.4/7.8 cm. Microscopy: in 8 KT of digestive origin, 3--signet-ring cell carcinoma, 3--mucinous adenocarcinoma, 2--mixed pattern; 1 KT or breast origin was diagnosed by immunohistochemistry; 6/9 presented microscopic peritoneal despite a lack of strong correlation with the appearance of carcinomatosis or cytology of ascites. Survival: 3--no evidence, 5--disease-free after 4-13 months, 1--survived 2 years after debulking (4 years after colectomy). Clinical, evolutive and prognostic features of KT are determined by the biologically behavior of the primary (rapid lymphatic and hematogenous spread to the ovary), so the benefit of surgery is limited. Bilateral ovarian tumors, particularly in premenopausal women, must raise a high index of suspicion for KT, before or during surgery; diagnosis is a team challenge.
authors.affiliation: Clinica de Chirurgie Generală şi Esofagiană Sfânta Maria, U.M.E Carol Davila, Bucureşti. dmates@gmail.com
authors.forename: I N
authors.initials: IN
authors.lastname: Mateş
authors.forename: Cristina
authors.initials: C
authors.lastname: Iosif
authors.forename: G
authors.initials: G
authors.lastname: Bănceanu
authors.forename: Mioara
authors.initials: M
authors.lastname: Ionescu
authors.forename: Gh
authors.initials: G
authors.lastname: Peltecu
authors.forename: Daniela
authors.initials: D
authors.lastname: Dinu
authors.forename: A
authors.initials: A
authors.lastname: Constantin
authors.forename: P
authors.initials: P
authors.lastname: Hoară
authors.forename: C
authors.initials: C
authors.lastname: Mitru
authors.forename: S
authors.initials: S
authors.lastname: Constantinoiu
mesh_terms: D000328:Adult; D001063:Appendiceal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D001943:Breast Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007725:Krukenberg Tumor / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome