title: Does pelvic organ prolapse reduction affect abdominal leak point pressures?
abstract: OBJECTIVE
  To determine if pelvic organ prolapse reduction decreases cystometric leak point pressure.
  
  
  METHODS
  A retrospective review was performed of women with pelvic organ prolapse points Aa, Ba or C > or = -1 cm that leaked with and without vaginal support (barrier testing) during multichannel urodynamic investigation (N=44). An analysis of the mean and difference between leak point pressure (LPP) (vesicle pressure) with and without prolapse reduction was used to determine significance.
  
  
  RESULTS
  Among 460 possible study subjects, 15% (71/460) leaked only with and 4% (17/460) only without prolapse reduction. Among the 44 women who leaked both with and without prolapse reduction, prolapse reduction was associated with a mean decrease in LPP of 16.1 cm H2O (95% CI 7.4-24.7, p = 0.0005).
  
  
  CONCLUSIONS
  Reduction of pelvic organ prolapse is associated with a mean decrease in LPP of 16.1 cm H2O.
authors.affiliation: Department of Obstetrics and Gynecology, Dartmouth Medical School, Hanover, New Hampshire 03756, USA. james.l.whiteside@hitchcock.org
authors.forename: James L
authors.initials: JL
authors.lastname: Whiteside
authors.forename: Alexei
authors.initials: A
authors.lastname: Viazmenski
authors.forename: Kris
authors.initials: K
authors.lastname: Strohbehn
authors.forename: Paul D
authors.initials: PD
authors.lastname: Hanissian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002404:Catheterization; D003371:Cough; D005260:Female; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D012189:Retrospective Studies; D014549:Urinary Incontinence / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology*; D014596:Uterine Prolapse / Q000503:physiopathology*; D014636:Valsalva Maneuver