MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature.
A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.
Soler
Gwendoline
G
Service de cytogénétique, Assistance PubliqueeHôpitaux de Paris, Centre Hospitalier Universitaire Necker-Enfants Malades, 149 rue de Sèvres, 75743, paris Cedex 15, France.
Radford
Isabelle
I
Meyer
Claus
C
Marschalek
Rolf
R
Brouzes
Chantal
C
Ghez
David
D
Romana
Serge
S
Berger
Roland
R
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D019457:Chromosome Breakage; D020732:Cytogenetic Analysis; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*
C497422:KMT2A protein, human; C529663:MLL-MLLT3 fusion protein, human; C489901:MLLT3 protein, human; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase