Poly ADP-ribose polymerase-1: an international molecule of mystery.
Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity.
Woodhouse
Bethany C
BC
Medical Research Council Radiation Oncology & Biology Unit, University of Oxford, Oxford OX3 7DQ, UK.
Dianov
Grigory L
GL
D000818:Animals; D016923:Cell Death; D004260:DNA Repair; D006801:Humans; D023421:Models, Animal; D008954:Models, Biological; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000502:physiology*
D011065:Poly(ADP-ribose) Polymerases