title: Phenolic glycosides from Lindera fruticosa root and their inhibitory activity on osteoclast differentiation.
abstract: Two new compounds were found in the phenolic glycosides isolated from the roots of Lindera fruticosa: 5-O-[beta-D-apiofuranosyl-(1''-->2')-O-beta-D-xylopyranosyl]gentisic acid-7,5''-ester (3), named linderofruticoside A; and 5-O-[beta-D-apiofuranosyl-(1''-->3')-O-beta-D-xylopyranosyl]gentisic acid methyl ester (4), linderofruticoside B. Two previously known phenolic glycosides were also identified: beta-D-(3,4-disinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside (1) and beta-D-(3-sinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside (2). Compounds 1 and 2 inhibited osteoclast differentiation in a dose-dependent manner at concentrations higher than 1.04 microM and 0.132 microM, respectively.
authors.affiliation: Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon, South Korea.
authors.forename: Myoung-Chong
authors.initials: MC
authors.lastname: Song
authors.forename: Fikru
authors.initials: F
authors.lastname: Nigussie
authors.forename: Hye-Joung
authors.initials: HJ
authors.lastname: Yang
authors.forename: Hong-Hee
authors.initials: HH
authors.lastname: Kim
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Dae-Kyun
authors.initials: DK
authors.lastname: Chung
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002454:Cell Differentiation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006868:Hydrolysis; D027443:Lindera / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D013055:Spectrophotometry, Infrared
chemical_list: D006027:Glycosides; D010636:Phenols; C529691:linderofruticoside A; C529692:linderofruticoside B