Urine analysis of patients exposed to phenylarsenic compounds via accidental pollution.
New methods involving high-performance liquid chromatography/inductively coupled plasma mass spectrometry were examined for the determination of phenylarsenic compounds derived from chemical warfare agents. Several methods were examined for the separation of diphenylarsinic acid (DPAA), phenylarsonic acid, phenylmethylarsinic acid (PMAA), phenyldimethylarsine oxide, and diphenylmethylarsine oxide. Analysis of the urine samples of the patients exposed to phenylarsenic compounds indicated that the main phenylarsenic components were DPAA and PMAA; moreover, some unknown arsenicals, which were also found in contaminated groundwater and rice samples, were also detected.
Kinoshita
Kenji
K
Laboratory of Environmental Chemodynamics, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. k2_theory@yahoo.co.jp
Noguchi
Ayano
A
Ishii
Kazuhiro
K
Tamaoka
Akira
A
Ochi
Takafumi
T
Kaise
Toshikazu
T
D000059:Accidents; D000818:Animals; D001152:Arsenicals / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004785:Environmental Pollutants / Q000652:urine*; D006801:Humans; D013058:Mass Spectrometry; D051379:Mice
D001152:Arsenicals; D004785:Environmental Pollutants