Substrate selectivity APPLies to Akt.
The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.
Zhao
Shimin
S
Laboratory of Molecular and Cellular Biology, Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Guan
Kun-Liang
KL
D000818:Animals; D004789:Enzyme Activation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
D029961:Zebrafish Proteins; D051057:Proto-Oncogene Proteins c-akt