Serum uric acid levels and risk of metabolic syndrome in healthy adults.
OBJECTIVE
To investigate the relationship between hyperuricemia and metabolic syndrome in a population of healthy subjects.


METHODS
We studied 1,573 healthy adults (25 to 64 years old) in the population laboratory of the Tehran University of Medical Sciences. The study was designed according to the World Health Organization MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) project with use of the National Cholesterol Education Program Adult Treatment Panel III criteria for metabolic syndrome.


RESULTS
The crude prevalence of the metabolic syndrome was 29.9% (age-adjusted, 27.5%). The rate of metabolic syndrome significantly increased in higher quartiles of serum uric acid in both sexes but especially in women (P<.0001 versus P = .026). The bivariate correlation was significant between uric acid levels and age, total serum cholesterol, high-density lipoprotein cholesterol, triglycerides, body mass index, waist and hip circumferences, waist-to-hip ratio, and systolic and diastolic blood pressures; however, there was not a significant correlation between serum uric acid concentrations and fasting plasma glucose.


CONCLUSIONS
These data indicate that an independent relationship exists between hyperuricemia and the metabolic syndrome. Moreover, hyperuricemia is significantly correlated with hypertriglyceridemia, hypertension, and visceral obesity. Early detection of hyperuricemia seems to be essential for prevention of the metabolic syndrome.
Ebrahimpour
Pantea
P
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fakhrzadeh
Hossein
H
Heshmat
Ramin
R
Bandarian
Fatemeh
F
Larijani
Bagher
B
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D015228:Hypertriglyceridemia / Q000097:blood; D033461:Hyperuricemia / Q000097:blood* / Q000175:diagnosis; D007492:Iran; D008297:Male; D008403:Mass Screening; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000517:prevention & control; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid