Nitric oxide, N omega-hydroxy-L-arginine and breast cancer.
Nitric oxide has varied effects on human breast cancer cells. At low concentration (micromolar range) it increases proliferation by increasing synthesis of some cells cycle protein and in higher concentration (nanomolar range) it leads to cytostasis or apoptosis by decreasing the translation of some cell cycle proteins.
Pervin
Shehla
S
Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-1740, USA.
Singh
Rajan
R
Chaudhuri
Gautam
G
D017209:Apoptosis; D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism; D001943:Breast Neoplasms / Q000473:pathology*; D018797:Cell Cycle Proteins; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*
D018797:Cell Cycle Proteins; D009569:Nitric Oxide; C068309:N(omega)-hydroxyarginine; D001120:Arginine