title: Combined retinol-lactose-glycolic acid effects on photoaged skin: a double-blind placebo-controlled study.
abstract: The objective of this study was to assess the efficacy of the combination of retinol, lactose and glycolic acid applied topically on photodamaged skin. Forty female volunteers were enrolled in a double-blind, randomized placebo-controlled clinical study. A cream containing retinol, lactose and glycolic acid was applied on one side of the face and a placebo cream on the other side, twice daily for 12 weeks. Skin photoageing signs were assessed clinically, whereas skin microrelief and moisturization were measured instrumentally. Both the clinical assessment and the objective instrumental measurements revealed that the active-treated side was significantly improved at the end of the study compared with baseline and control-treated side. In conclusion, our results demonstrate that topical application of a combination of retinol, lactose and glycolic acid has significantly improved the appearance of photodamaged skin.
authors.affiliation: Johnson & Johnson Consumer France, 1 rue Camille Desmoulins, 92787 Issy-les-Moulineaux, France. cbertin@jnjfr.jnj.com
authors.forename: C
authors.initials: C
authors.lastname: Bertin
authors.forename: H
authors.initials: H
authors.lastname: Zunino
authors.forename: M
authors.initials: M
authors.lastname: Lanctin
authors.forename: G N
authors.initials: GN
authors.lastname: Stamatas
authors.forename: E
authors.initials: E
authors.lastname: Camel
authors.forename: C
authors.initials: C
authors.lastname: Robert
authors.forename: N
authors.initials: N
authors.lastname: Issachar
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001706:Biopsy; D004311:Double-Blind Method; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects; D006016:Glycolates / Q000008:administration & dosage*; D006801:Humans; D007785:Lactose / Q000008:administration & dosage*; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D013472:Sunlight / Q000009:adverse effects*; D014801:Vitamin A / Q000008:administration & dosage*
chemical_list: D006016:Glycolates; C031149:glycolic acid; D014801:Vitamin A; D007785:Lactose