title: Peak mitral annular velocity during early diastole and propagation velocity of early diastolic filling flow are not interchangeable as the parameters of left ventricular early diastolic function.
abstract: The difference between peak mitral annular velocity during early diastole (Ea) and the propagation velocity of left ventricular (LV) early diastolic filling flow (Vp) obtained using Doppler imaging as LV relaxation parameters was not fully elucidated. Thus, this issue was investigated in 117 patients with suspected coronary artery disease. During cardiac catheterization, LV volumes, the LV relaxation time constant Tp, and inertia force of late systolic aortic flow were obtained. Ea significantly and closely correlated with Tp (r = -0.70, p <0.0001) and significantly but weakly correlated with LV ejection fraction (r = 0.37, p <0.0001) and inertia force (r = 0.34, p = 0.0002). Conversely, Vp significantly and closely correlated with both LV ejection fraction (r = 0.66, p <0.0001) and inertia force (r = 0.72, p <0.0001) and significantly but weakly correlated with Tp (r = - 0.35, p = 0.0001). In conclusion, Ea and Vp reflect different aspects of LV behavior from end-systole to early diastole. Ea can be used to index LV relaxation, whereas Vp might not be a proper parameter of LV intrinsic relaxation because it is significantly dependent on LV systolic function and LV chamber size at end-systole. Both parameters are not interchangeable as those of LV early diastolic function. Vp may be a noninvasive parameter of LV elastic recoil.
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Hiroumi
authors.initials: H
authors.lastname: Mizuno
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Wakami
authors.forename: Hitomi
authors.initials: H
authors.lastname: Narita
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Fukuta
authors.forename: Kaoru
authors.initials: K
authors.lastname: Asada
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kimura
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D006328:Cardiac Catheterization / Q000379:methods; D003327:Coronary Disease / Q000175:diagnosis / Q000503:physiopathology*; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000502:physiology*; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*