title: Flexible porous metal-organic frameworks for a controlled drug delivery.
abstract: Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
authors.affiliation: Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Horcajada
authors.forename: Christian
authors.initials: C
authors.lastname: Serre
authors.forename: Guillaume
authors.initials: G
authors.lastname: Maurin
authors.forename: Naseem A
authors.initials: NA
authors.lastname: Ramsahye
authors.forename: Francisco
authors.initials: F
authors.lastname: Balas
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
authors.forename: Muriel
authors.initials: M
authors.lastname: Sebban
authors.forename: Francis
authors.initials: F
authors.lastname: Taulelle
authors.forename: Gérard
authors.initials: G
authors.lastname: Férey
mesh_terms: D000327:Adsorption; D017608:Chromium Compounds / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D008958:Models, Molecular; D010795:Phthalic Acids / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D017608:Chromium Compounds; D003692:Delayed-Action Preparations; D005290:Ferric Compounds; D010795:Phthalic Acids; C011363:terephthalic acid; D007052:Ibuprofen