Tumour necrosis factor-alpha (TNFalpha) stimulates the growth of human bone marrow stromal cells.
This study reports that TNF-alpha is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [(3)H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1alpha, IL-1beta, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-alpha on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.
Rougier
F
F
Laboratoire d'Hématologie Expérimentale Faculté de Médecine 2 rue Dr. Marcland Limoges 87025 France.
Cornu
E
E
Gachard
N
N
Praloran
V
V
Denizot
Y
Y