Association of Hb Q-Thailand with heterozygous Hb E in a Chinese patient.
We describe a Chinese patient who was heterozygous for both Hb Q-Thailand [alpha74(EF3)Asp-->His] and Hb E [beta26(B7)Gly-->Asp, GAG-->GTG]. Interaction of the alpha(Q-Thailand) and beta(E) chains leads to a hemoglobin (Hb) variant, namely Hb QE, which differs in electrophoretic mobility and high performance liquid chromatography (HPLC) profiles and in the amount of the Hb Q-Thailand variant present in the blood.
Li
Dongzhi
D
Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China.
Liao
Can
C
Li
Jian
J
Xie
Xingmei
X
Zhong
Huizhu
H
D000328:Adult; D044466:Asian People; D002648:Child; D005260:Female; D006446:Hemoglobin E / Q000031:analogs & derivatives* / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D006442:Glycated Hemoglobin
D006446:Hemoglobin E; D006455:Hemoglobins, Abnormal; C032271:glycated hemoglobin E; D006442:Glycated Hemoglobin; C049214:hemoglobin Q Thailand