Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children.
OBJECTIVE
Adenotonsillar hypertrophy can cause upper airway obstruction and may be associated with growth delay in children. The objective of this study was to evaluate the long-term effects of adenotonsillectomy on height, weight, and body mass index (BMI) in children with sleep-disordered breathing (SDB).


METHODS
Fifty-two children (mean age 6.2+/-2.3 years) clinically diagnosed with SDB were enrolled. Children were diagnosed and scheduled for adenotonsillectomy (T&A) based on their responses to the validated, 22-item Sleep Related Breathing Disorder (SRDB) scale and a physical examination that showed adenotonsillar hypertrophy. Weight, height, and BMI were evaluated before and 5 years after T&A. Serum levels of insulin-like growth factor-1 (IGF-1) were measured before and 1 month after T&A.


RESULTS
Serum levels of IGF-1 were significantly higher at 1 month after T&A compared to before T&A (p<0.001). Thirty children (58%) returned for follow-up testing 5 years later. Their Z scores (standard deviation scores) for weight, height, and BMI of 30 children were significantly higher 5 years after T&A compared to before T&A (p<0.01).


CONCLUSIONS
Children with SDB who undergo adenotonsillectomy show significant, long-term increases in weight, height and BMI, as well as a significant increase in serum levels of IGF-1.
Kang
Jun-Myung
JM
Department of Otolaryngology-HNS, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. entkjm@catholic.ac.kr
Auo
Hyeon-Jin
HJ
Yoo
Young-Hwa
YH
Cho
Jin-Hee
JH
Kim
Byung-Guk
BG
D000233:Adenoidectomy; D000234:Adenoids / Q000473:pathology; D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D006801:Humans; D006984:Hypertrophy; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology; D020181:Sleep Apnea, Obstructive / Q000209:etiology / Q000601:surgery; D014068:Tonsillectomy
D007334:Insulin-Like Growth Factor I