title: Seoul virus in patients and rodents from Beijing, China.
abstract: Hemorrhagic fever with renal syndrome (HFRS) is a significant public health problem with an increasing incidence in Beijing, China (report of disease surveillance from the Center for Disease Control and Prevention of Beijing, China). Hantaviruses were detected using RT-PCR method in blood samples of HFRS patients and lung tissues of rodents captured in Beijing. Phylogenetic analyses of 724bp partial S segment of the hantavirus gene showed that the detected Seoul virus (SEOV) fell into three different lineages, two of which circulated in Beijing. A nucleotide sequence identity of 99.7% for one of the cases of HFRS--the human- and Rattus norvegicus-originated SEOV sequences--had only two silent substitutions, suggesting genetic analysis is an essential tool for "case-investigation."
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.
authors.forename: Shu-qing
authors.initials: SQ
authors.lastname: Zuo
authors.forename: Pan-he
authors.initials: PH
authors.lastname: Zhang
authors.forename: Jia-fu
authors.initials: JF
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhan
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Wu
authors.forename: Wen-juan
authors.initials: WJ
authors.lastname: Zhao
authors.forename: Ri-min
authors.initials: RM
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Tang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Dun
authors.forename: Wu-chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000818:Animals; D017931:DNA Primers; D005843:Geography; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D010802:Phylogeny; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012376:Rodent Diseases / Q000453:epidemiology / Q000821:virology; D029263:Seoul virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification
chemical_list: D017931:DNA Primers