Kinetic analysis of the MAPK and PI3K/Akt signaling pathways.
Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.
C V
Suresh Babu
SB
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. BOX 131, Cheongryang, Seoul 130-650, Korea.
Babar
Sheikh Md Enayetul
SM
Song
Eun Joo
EJ
Oh
Eulsik
E
Yoo
Young Sook
YS
D003198:Computer Simulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D007700:Kinetics; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D048490:raf Kinases / Q000378:metabolism
D004791:Enzyme Inhibitors; D020800:Receptor, Nerve Growth Factor; D019869:Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors; D051057:Proto-Oncogene Proteins c-akt; D048490:raf Kinases; D048049:Extracellular Signal-Regulated MAP Kinases