Partial HLA matching and RH incompatibility resulting in graft versus host reaction and Evans syndrome after liver transplantation.
We report a case of a 67-year-old male who underwent OLT from a deceased, sex-matched donor. Two months later he developed Evans syndrome and GVHD of the skin. Donor and recipient were matched for HLA-A and -B loci in the direction of rejection but mismatched in the direction of GVHD and fully mismatched for DRB1. These mismatches were permissible for engraftment of donor T-cells but led to GVHD. Chimerism appeared restricted to the T-cell compartment. In this case, partially matched passenger lymphocytes triggered a graft versus host reaction. In addition, alloantibodies caused cytopenias that improved after immunosuppression. HLA typing was critical in confirming this rare diagnosis and elucidating its cause. Recipients of solid organs from donors that are partially matched in the direction of rejection may need to be closely monitored for GVHD.
Grosskreutz
Celia
C
Bone Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Mount Sinai Medical Center, New York, New York, USA.
Gudzowaty
Oksana
O
Shi
Patricia
P
Rodriguez-Laiz
Gonzalo
G
Malone
Adriana
A
Isola
Luis
L
D000368:Aged; D001771:Blood Banks; D001787:Blood Group Incompatibility / Q000276:immunology*; D046528:Chimerism; D006087:Graft vs Host Reaction / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D013577:Syndrome
D006680:HLA Antigens; D012204:Rh-Hr Blood-Group System