title: Inhibitory effect against Akt of cyclic dipeptides isolated from Bacillus sp.
abstract: Among thirteen strains of the genus Bacillus isolated from Shrimp-jeotkal in our laboratory, a strain BA34 showing good antifungal activity against Phytophthora infestans in a previous experiment was tested for the inhibitory effect against Akt, protein kinase B. Since Akt is known to play an important role in controlling apoptosis, its inhibitors can be used as potential apoptosis-inducing agents in the treatment of cancer. Two active compounds were isolated and their structures were determined. They have similar structures, despite showing different inhibitory effects. In order to elucidate the reasons for these different effects, three-dimensional studies were carried out.
authors.affiliation: Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea.
authors.forename: Sungwon
authors.initials: S
authors.lastname: Hong
authors.forename: Byoung-Ho
authors.initials: BH
authors.lastname: Moon
authors.forename: Yeonjoong
authors.initials: Y
authors.lastname: Yong
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Shin
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000818:Animals; D001407:Bacillus / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D045744:Cell Line, Tumor; D033364:Decapoda / Q000382:microbiology*; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004151:Dipeptides; D004791:Enzyme Inhibitors; D051057:Proto-Oncogene Proteins c-akt