Antecedents and sequelae of sudden parental death in offspring and surviving caregivers.
OBJECTIVE
To examine the psychiatric antecedents that put parents at risk for early death, and the psychological sequelae of bereavement in offspring and caregivers.


METHODS
A population-based study.


METHODS
Bereaved families were recruited through the coroner's records and by advertisement. Control families were recruited by random-digit dialing and advertisement.


METHODS
Families with biological offspring from 7 to 25 years of age in which 1 parent died of suicide, accident, or sudden natural death were included (n = 140). Controls (n = 99) had 2 living parents and their biological offspring and had no death of a first-degree relative within the past 2 years.


METHODS
Lifetime psychiatric history for deceased parents (probands) and new-onset psychiatric disorders, self-reported symptoms, and functional status in offspring and surviving caregivers.


RESULTS
Bipolar disorder, substance abuse, and personality disorders are more common in probands who died of suicide or accident than in control parents. Bereaved offspring and their caregivers were at increased risk for depression and posttraumatic stress disorder. Bereaved offspring had a 3-fold (95% confidence interval, 1.3-7.0) increased risk of depression, even after controlling for antecedent and concomitant risk factors. Offspring bereaved by suicide showed similar outcomes compared with those bereaved by other types of death.


CONCLUSIONS
Bereavement conveys an increased risk of depression and posttraumatic stress disorder above and beyond other vulnerability factors. Better integration of medical and psychiatric care may prevent premature parental death, but once it occurs, physicians should be alert to the increased risk for depression and posttraumatic stress disorder in bereaved offspring and their caregivers.
Melhem
Nadine M
NM
Western Psychiatric Institute and Clinic and the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Walker
Monica
M
Moritz
Grace
G
Brent
David A
DA
D000293:Adolescent; D000328:Adult; D001601:Bereavement; D017028:Caregivers / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D003645:Death, Sudden; D003863:Depression / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology*; D010290:Parents / Q000523:psychology; D011446:Prospective Studies; D000297:Psychology, Adolescent; D002666:Psychology, Child; D012307:Risk Factors; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology; D013405:Suicide / Q000523:psychology