RNA polymerase II stalling: loading at the start prepares genes for a sprint.
Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received.
Wu
Jia Qian
JQ
Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, New Haven, CT 06511, USA. Michael.Snyder@yale.edu
Snyder
Michael
M
D000818:Animals; D016678:Genome; D006801:Humans; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic
D012319:RNA Polymerase II