title: Pilot study: understanding the effects of voicing intervention on HFCC therapy in people with cystic fibrosis.
abstract: The efficacy of High-Frequency Chest Compression (HFCC) airway clearance therapy is linked to the induced-peak expiratory airflow pulse (IPEF) at the patient's mouth. The authors' goal was to determine the conditions that yield the highest IPEF using HFCC running at 6Hz in conjunction with voicing intervention. A pilot experimental study was conducted in a laboratory setting. Six adults with moderate to mild cystic fibrosis (CF) and 10 healthy adults participated. When the component characteristics of voicing were disregarded in data analysis of four conditions, voicing only intervention (V(1)I(0)), HFCC only intervention (V(0)I(1)), voicing intervention and HFCC intervention combinations (V(1)I(1)) and nonintervention (V(0)I(0)), V(0)I(1) had significantly higher (P<0.0001) IPEF. Data analyses of 64 separate voicing component characteristics, frequency (x4), amplitude (x4), and rhythm (x2) of voicing intervention, in addition to absence and presence of HFCC intervention (V(1)I(0) and V(1)I(1)), were examined. One condition in V(1)I(0) had significantly higher (P<0.000001) IPEF than other conditions in V(1)I(0) and V(1)I(1) in both experimental and control groups. Based on these findings, V(1)I(1) may yield higher IPEF than V(0)I(1). One condition of amplitude component of voicing and one condition of rhythm component of voicing had significantly higher (P<0.0001) IPEF than other conditions of amplitude and rhythm components in both CF and control subjects. Analysis of this combined condition of V(1)I(1) showed that this specific condition of V(1)I(1) had significantly higher (P<0.000001) IPEF than any other conditions in V(1)I(1) and V(0)I(1).
authors.affiliation: Program in Rehabilitation Science, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Wha Jung
authors.initials: WJ
authors.lastname: Yoo
authors.forename: Jane
authors.initials: J
authors.lastname: Braverman
authors.forename: Yong Wan
authors.initials: YW
authors.lastname: Lee
authors.forename: Leland
authors.initials: L
authors.lastname: Hansen
authors.forename: Mario
authors.initials: M
authors.lastname: Nozzarella
mesh_terms: D000328:Adult; D000399:Air Pressure; D000704:Analysis of Variance; D035641:Chest Wall Oscillation; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D009055:Mouth / Q000503:physiopathology; D010865:Pilot Projects; D014831:Voice; D014834:Voice Training; D055815:Young Adult