NK-cell intravascular lymphomatosis--a mini-review.
The majority of cases of intravascular lymphomatosis (IVL) is derived from B cells. However, IVL may also arise from T cells, or more rarely NK cells. The clinicopathological findings in six cases of NK-cell IVL (NK-IVL), including one new case, were summarised and compared with B-cell IVL (B-IVL) and T-cell IVL (T-IVL). Earlier onset of disease and female predominance were found in NK-IVL. NK-IVL was typically Epstein-Barr virus (EBV)-positive, whereas EBV was rarely detected in B-IVL. Cutaneous manifestations were common in NK-IVL with constant EBV infection. B-IVL showed a more favourable prognosis than T- or NK-IVL. Irrespective of immunophenotype, however, IVL showed a less favourable prognosis than ordinary lymphomas within the same immunophenotype. In summary, IVL of the B-, T- and NK-cell phenotypes is clinicopathologically distinct and shows similarities to their more common counterparts, i.e. diffuse large B-cell lymphoma, peripheral T-cell lymphoma, unspecified and extranodal NK/T-cell lymphoma, nasal type.
Nakamichi
Naoto
N
Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan.
Fukuhara
Shirou
S
Aozasa
Katsuyuki
K
Morii
Eiichi
E
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D016393:Lymphoma, B-Cell; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D016399:Lymphoma, T-Cell; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000821:virology
D000970:Antineoplastic Agents