title: Epigenetic control: slow and global, nimble and local.
abstract: The regulation of gene expression involves multiple levels of control, from those that are inheritable to those that are highly responsive to environmental changes. In this issue of Genes & Development, Dong and colleagues (pp. 1159-1173) demonstrate that the dynamically controlled immune response transcription factor NF-kappaB may, in fact, have a role in regulating heterochromatin and gene expression at large distances from its actual target sequences and genes.
authors.affiliation: Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
authors.forename: Christine S
authors.initials: CS
authors.lastname: Cheng
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Johnson
authors.forename: Alexander
authors.initials: A
authors.lastname: Hoffmann
mesh_terms: D000107:Acetylation; D000818:Animals; D004622:Embryo, Mammalian / Q000196:embryology; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006655:Histone Deacetylases / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D052002:NF-kappa B p50 Subunit / Q000235:genetics* / Q000378:metabolism; D010766:Phosphorylation
chemical_list: D052002:NF-kappa B p50 Subunit; D006655:Histone Deacetylases