Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens.
Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox.
Fernandes
Daniara Cristina
DC
NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University, Brazil.
Regasini
Luis Octávio
LO
Vellosa
José Carlos Rebuglio
JC
Pauletti
Patrícia Mendonça
PM
Castro-Gamboa
Ian
I
Bolzani
Vanderlan Silva
VS
Oliveira
Olga Maria Mascarenhas
OM
Silva
Dulce Helena Siqueira
DH
D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
D052160:Benzothiazoles; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D047309:Flavones; D016166:Free Radical Scavengers; D005960:Glucosides; D010851:Picrates; D013451:Sulfonic Acids; C529725:nitensoside A; C529726:nitensoside B; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D009195:Peroxidase