title: Familial poikylodermic cutaneous amyloidosis.
abstract: Among the less common variants of primary cutaneous amyloidosis are both the poikylodermic and the familial types. The case of two sisters of thirteen and seventeen years old with extensive asymptomatic lesions with a poikylodermic aspect is reported. The girls' father was also affected and a paternal aunt had consulted at our department some years previously for similar lesions. Thus a new case of familial cutaneous amyloidosis with an autosomal dominant hereditary pattern is described. The possible relationship between multiple endocrine neoplasia type 2A (MEN-2A) and familial cutaneous amyloidosis is discussed.
authors.affiliation: Hospital Universitario de Salamanca, Servicio de Dermatología, Paseo de San Vicente 58-132, 37007 Salamanca, Spain. pardolourdes@yahoo.es
authors.forename: Lourdes
authors.initials: L
authors.lastname: Pardo Arranz
authors.forename: Pilar
authors.initials: P
authors.lastname: Escalonilla García-Patos
authors.forename: Concepción
authors.initials: C
authors.lastname: Román Curto
authors.forename: Susana
authors.initials: S
authors.lastname: Blanco Barrios
authors.forename: Emilia
authors.initials: E
authors.lastname: Fernández López
authors.forename: Pablo
authors.initials: P
authors.lastname: de Unamuno Pérez
mesh_terms: D000293:Adolescent; D000682:Amyloid / Q000032:analysis*; D028226:Amyloidosis, Familial / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D018813:Multiple Endocrine Neoplasia Type 2a / Q000150:complications; D010375:Pedigree; D010859:Pigmentation Disorders / Q000209:etiology* / Q000235:genetics; D012867:Skin / Q000378:metabolism / Q000473:pathology*
chemical_list: D000682:Amyloid