Mechanisms for the effect of arginine-containing dermorphin analogue on proliferative processes in the gastric mucosa of albino rats.
Treatment with synthetic arginine-containing dermorphin analogue sedatin (100 mg/kg, 5 intraperitoneal injections) stimulated DNA synthesis in the gastric mucosa and decreased spontaneous and induced chemiluminescence in homogenates of the stomach from albino rats. Non-arginine sedatin analogue in the same dose had little effect on DNA synthesis and free radical oxidation. Fivefold treatment with NO synthase inhibitor L-NAME (9.3 x 10(-5) mol/kg) suppressed DNA synthesis in the gastric mucosa. Sedatin did not modulate DNA synthesis against the background of L-NAME administration.
Fleishman
M U
MU
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk.
Zhivotova
E U
EU
Lebedko
O A
OA
Deigin
V I
VI
Timoshin
S S
SS
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D009842:Oligopeptides / Q000235:genetics / Q000494:pharmacology*; D018847:Opioid Peptides / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology; D051381:Rats
D009842:Oligopeptides; D018847:Opioid Peptides; C493049:sedatin; C030058:dermorphin; D004247:DNA; D001120:Arginine