New properties of immunotropic preparation from porcine skin.
We studied new immunological and physicochemical properties of K-activin, immunotropic preparation from porcine skin isolated by the acetone method. The preparation restored the sensitivity of background rosette-forming cells in the spleen of thymectomized mice to the inhibitory effect of azathioprine in vivo and practically normalized serum thymic activity reduced in thymectomized mice. The molecular weight of proteins present in K-activin and previously detected by SDS-PAAG electrophoresis was determined by MALDI mass spectrometry
Belova
O V
OV
Laboratory of Molecular Immunology, Laboratory of Artificial Antibodygenesis, Institute of Physicochemical Medicine, Federal Agency on Health Care and Social Development, Moscow. olga.belova@ripcm.org.ru
Arion
V Y
VY
Zimina
I V
IV
Lukandina
T A
TA
Krotova
S B
SB
Sysoeva
O B
OB
Tret'yakov
V A
VA
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001379:Azathioprine / Q000378:metabolism; D003879:Dermatologic Agents / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000737:chemistry / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013552:Swine
D000276:Adjuvants, Immunologic; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D001379:Azathioprine