A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides.
A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally stable, are easily activated under normal reaction conditions at or below room temperature, and ensure the formation of the highly active monoligated Pd(0) complex necessary for oxidative addition. The use of these precatalysts as a convenient source of LPd(0) in C-N cross-coupling reactions is explored. The reactivity that is demonstrated in this study is unprecedented in palladium chemistry.
Biscoe
Mark R
MR
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fors
Brett P
BP
Buchwald
Stephen L
SL
D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D002722:Chlorobenzenes / Q000737:chemistry*; D003080:Cold Temperature; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry
D000814:Aniline Compounds; D002722:Chlorobenzenes; D008024:Ligands; D010720:Phosphines; D010165:Palladium