DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders.
The co-stimulatory adhesion molecule DNAX accessory molecule 1 (DNAM-1) is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. Thus, DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases. The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed.
Elishmereni
Moran
M
The Hebrew University of Jerusalem, Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, POB 12065, Jerusalem 91120, Israel.
Bachelet
Ido
I
Levi-Schaffer
Francesca
F
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D015815:Cell Adhesion Molecules / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy; D008024:Ligands; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D011991:Receptors, Virus / Q000276:immunology; D015398:Signal Transduction; D000098862:T Lineage-Specific Activation Antigen 1
D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1; D015815:Cell Adhesion Molecules; D008024:Ligands; D011991:Receptors, Virus; C066100:poliovirus receptor