title: Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children.
abstract: OBJECTIVE
  Adenotonsillar hypertrophy can cause upper airway obstruction and may be associated with growth delay in children. The objective of this study was to evaluate the long-term effects of adenotonsillectomy on height, weight, and body mass index (BMI) in children with sleep-disordered breathing (SDB).
  
  
  METHODS
  Fifty-two children (mean age 6.2+/-2.3 years) clinically diagnosed with SDB were enrolled. Children were diagnosed and scheduled for adenotonsillectomy (T&A) based on their responses to the validated, 22-item Sleep Related Breathing Disorder (SRDB) scale and a physical examination that showed adenotonsillar hypertrophy. Weight, height, and BMI were evaluated before and 5 years after T&A. Serum levels of insulin-like growth factor-1 (IGF-1) were measured before and 1 month after T&A.
  
  
  RESULTS
  Serum levels of IGF-1 were significantly higher at 1 month after T&A compared to before T&A (p<0.001). Thirty children (58%) returned for follow-up testing 5 years later. Their Z scores (standard deviation scores) for weight, height, and BMI of 30 children were significantly higher 5 years after T&A compared to before T&A (p<0.01).
  
  
  CONCLUSIONS
  Children with SDB who undergo adenotonsillectomy show significant, long-term increases in weight, height and BMI, as well as a significant increase in serum levels of IGF-1.
authors.affiliation: Department of Otolaryngology-HNS, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. entkjm@catholic.ac.kr
authors.forename: Jun-Myung
authors.initials: JM
authors.lastname: Kang
authors.forename: Hyeon-Jin
authors.initials: HJ
authors.lastname: Auo
authors.forename: Young-Hwa
authors.initials: YH
authors.lastname: Yoo
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Byung-Guk
authors.initials: BG
authors.lastname: Kim
mesh_terms: D000233:Adenoidectomy; D000234:Adenoids / Q000473:pathology; D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D006801:Humans; D006984:Hypertrophy; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology; D020181:Sleep Apnea, Obstructive / Q000209:etiology / Q000601:surgery; D014068:Tonsillectomy
chemical_list: D007334:Insulin-Like Growth Factor I