Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
BACKGROUND
Depression has incidentally been related to altered levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), but this relation has never been studied systematically.


OBJECTIVE
To determine in a large population-based cohort whether there is an association between depression and altered 25(OH)D and PTH levels.


METHODS
Population-based cohort study (Longitudinal Aging Study Amsterdam).


METHODS
One thousand two hundred eighty-two community residents aged 65 to 95 years.


METHODS
The Netherlands.


METHODS
Depression was measured using self-reports (Center for Epidemiologic Studies-Depression scale) and diagnostic interviews (Diagnostic Interview Schedule). Levels of 25(OH)D and PTH were assessed. Potentially confounding factors (ie, age, sex, smoking status, body mass index, number of chronic conditions, and serum creatinine concentration) and explanatory factors (ie, season of data acquisition, level of urbanization, and physical activity) were also measured.


RESULTS
Levels of 25(OH)D were 14% lower in 169 persons with minor depression and 14% lower in 26 persons with major depressive disorder compared with levels in 1087 control individuals (P < .001). Levels of PTH were 5% and 33% higher, respectively (P = .003). Depression severity (Center for Epidemiologic Studies Depression Scale) was significantly associated with decreased serum 25(OH)D levels (P = .03) and increased serum PTH levels (P = .008).


CONCLUSIONS
The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.
Hoogendijk
Witte J G
WJ
Research Institute Neurosciences and the Center for Neurogenomics and Cognitive Research, VU University Medical Center, Vrije Universiteit Amsterdam, A. J. Ernststraat 887, 1081 HL, Amsterdam, The Netherlands. witteh@ggzba.nl
Lips
Paul
P
Dik
Miranda G
MG
Deeg
Dorly J H
DJ
Beekman
Aartjan T F
AT
Penninx
Brenda W J H
BW
D000368:Aged; D015331:Cohort Studies; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D005163:Factor Analysis, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012307:Risk Factors; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications*
D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D