Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum.
Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000-fold concentration gradient across the membrane. Its crystal structures have been determined for nine different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, which is achieved by a series of very large domain rearrangements.
Toyoshima
Chikashi
C
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. ct@iam.u-tokyo.ac.jp
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
D000252:Calcium-Transporting ATPases; D002118:Calcium