title: Salmonellosis outcomes differ substantially by serotype.
abstract: BACKGROUND
  Most human infections are caused by closely related serotypes within 1 species of Salmonella. Few data are available on differences in severity of disease among common serotypes.
  
  
  METHODS
  We examined data from all cases of Salmonella infection in FoodNet states during 1996-2006. Data included serotype, specimen source, hospitalization, and outcome.
  
  
  RESULTS
  Among 46,639 cases, 687 serotypes were identified. Overall, 41,624 isolates (89%) were from stool specimens, 2524 (5%) were from blood, and 1669 (4%) were from urine; 10,393 (22%) cases required hospitalization, and death occurred in 219 (0.5%). The case fatality rate for S. Newport (0.3%) was significantly lower than for Typhimurium (0.6%); Dublin (3.0%) was higher. With respect to invasive disease, 13 serotypes had a significantly higher proportion than Typhimurium (6%), including Enteritidis (7%), Heidelberg (13%), Choleraesuis (57%), and Dublin (64%); 13 serotypes were significantly less likely to be invasive. Twelve serotypes, including Enteritidis (21%) and Javiana (21%), were less likely to cause hospitalization than Typhimurium (24%); Choleraesuis (60%) was significantly more so.
  
  
  CONCLUSIONS
  Salmonella serotypes are closely related genetically yet differ significantly in their pathogenic potentials. Understanding the mechanisms responsible for this may be key to a more general understanding of the invasiveness of intestinal bacterial infections.
authors.affiliation: Communicable and Environmental Disease Services, Tennessee Department of Health, 1st Floor, Cordell Hull Bldg., 425 5th Ave. N., Nashville, TN 37243, USA. tim.f.jones@state.tn.us
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Jones
authors.forename: L Amanda
authors.initials: LA
authors.lastname: Ingram
authors.forename: Paul R
authors.initials: PR
authors.lastname: Cieslak
authors.forename: Duc J
authors.initials: DJ
authors.lastname: Vugia
authors.forename: Melissa
authors.initials: M
authors.lastname: Tobin-D'Angelo
authors.forename: Sharon
authors.initials: S
authors.lastname: Hurd
authors.forename: Carlota
authors.initials: C
authors.lastname: Medus
authors.forename: Alicia
authors.initials: A
authors.lastname: Cronquist
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Angulo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012475:Salmonella / Q000145:classification* / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology*; D012703:Serotyping; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D014774:Virulence