title: Optical measurement of neural activity using surface plasmon resonance.
abstract: We demonstrate that surface plasmon resonance (SPR) is applicable to the optical detection of neural signals. A low-noise SPR sensor was developed as a label- and artifact-free method for the extracellular recording of neural activity. The optical responses obtained from a rat sciatic nerve were highly correlated with simultaneously recorded electrical responses. Additional studies with stimulation intensity and lidocaine further confirmed that the optically measured signals originated from neural activities.
authors.affiliation: School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea, 151-742.
authors.forename: Shin
authors.initials: S
authors.lastname: Ae Kim
authors.forename: Kyung
authors.initials: K
authors.lastname: Min Byun
authors.forename: Jonghwan
authors.initials: J
authors.lastname: Lee
authors.forename: Jung
authors.initials: J
authors.lastname: Hoon Kim
authors.forename: Dong-Ghi
authors.initials: DG
authors.lastname: Albert Kim
authors.forename: Hyoungwon
authors.initials: H
authors.lastname: Baac
authors.forename: Michael L
authors.initials: ML
authors.lastname: Shuler
authors.forename: Sung
authors.initials: S
authors.lastname: June Kim
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004594:Electrophysiology; D008012:Lidocaine / Q000494:pharmacology; D055095:Optics and Photonics; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*; D020349:Surface Plasmon Resonance / Q000379:methods
chemical_list: D008012:Lidocaine