Pathophysiology of restless legs syndrome: evidence for iron involvement.
Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.
Connor
James R
JR
G.M. Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University, Milton S. Hershey Medical Center, 500 University Drive, PO Box 850, Hershey, PA 17033, USA. jconnor@psu.edu
D018798:Anemia, Iron-Deficiency / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D006801:Humans; D007501:Iron / Q000378:metabolism*; D012148:Restless Legs Syndrome / Q000378:metabolism* / Q000503:physiopathology*
D007501:Iron