title: Malin: maximum likelihood analysis of intron evolution in eukaryotes.
abstract: Malin is a software package for the analysis of eukaryotic gene structure evolution. It provides a graphical user interface for various tasks commonly used to infer the evolution of exon-intron structure in protein-coding orthologs. Implemented tasks include the identification of conserved homologous intron sites in protein alignments, as well as the estimation of ancestral intron content, lineage-specific intron losses and gains. Estimates are computed either with parsimony, or with a probabilistic model that incorporates rate variation across lineages and intron sites.
  
  
  BACKGROUND
  Malin is available as a stand-alone Java application, as well as an application bundle for MacOS X, at the website http://www.iro.umontreal.ca/~csuros/introns/malin/. The software is distributed under a BSD-style license.
authors.affiliation: Department of Computer Science and Operations Research, University of Montréal, Montréal, Québec, Canada. csuros@iro.umontreal.ca
authors.forename: Miklós
authors.initials: M
authors.lastname: Csurös
mesh_terms: D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D004252:DNA Mutational Analysis / Q000379:methods*; D019143:Evolution, Molecular; D006801:Humans; D007438:Introns / Q000235:genetics*; D016013:Likelihood Functions; D008969:Molecular Sequence Data; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software