title: Ontology Design Patterns for bio-ontologies: a case study on the Cell Cycle Ontology.
abstract: BACKGROUND
  Bio-ontologies are key elements of knowledge management in bioinformatics. Rich and rigorous bio-ontologies should represent biological knowledge with high fidelity and robustness. The richness in bio-ontologies is a prior condition for diverse and efficient reasoning, and hence querying and hypothesis validation. Rigour allows a more consistent maintenance. Modelling such bio-ontologies is, however, a difficult task for bio-ontologists, because the necessary richness and rigour is difficult to achieve without extensive training.
  
  
  RESULTS
  Analogous to design patterns in software engineering, Ontology Design Patterns are solutions to typical modelling problems that bio-ontologists can use when building bio-ontologies. They offer a means of creating rich and rigorous bio-ontologies with reduced effort. The concept of Ontology Design Patterns is described and documentation and application methodologies for Ontology Design Patterns are presented. Some real-world use cases of Ontology Design Patterns are provided and tested in the Cell Cycle Ontology. Ontology Design Patterns, including those tested in the Cell Cycle Ontology, can be explored in the Ontology Design Patterns public catalogue that has been created based on the documentation system presented (http://odps.sourceforge.net/).
  
  
  CONCLUSIONS
  Ontology Design Patterns provide a method for rich and rigorous modelling in bio-ontologies. They also offer advantages at different development levels (such as design, implementation and communication) enabling, if used, a more modular, well-founded and richer representation of the biological knowledge. This representation will produce a more efficient knowledge management in the long term.
authors.affiliation: School of Computer Science, University of Manchester, Oxford Road, M13 9PL Manchester, UK. mikel.eganaaranguren@cs.man.ac.uk
authors.forename: Mikel Egaña
authors.initials: ME
authors.lastname: Aranguren
authors.forename: Erick
authors.initials: E
authors.lastname: Antezana
authors.forename: Martin
authors.initials: M
authors.lastname: Kuiper
authors.forename: Robert
authors.initials: R
authors.lastname: Stevens
mesh_terms: D001185:Artificial Intelligence; D002453:Cell Cycle; D019295:Computational Biology / Q000379:methods* / Q000639:trends*; D003628:Database Management Systems / Q000639:trends*; D016208:Databases, Factual / Q000145:classification / Q000639:trends; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods / Q000639:trends; D012660:Semantics; D014584:User-Computer Interface; D018875:Vocabulary, Controlled