title: Cryptogenic stroke in a boy with atrial septal defect and hyperhomocysteinemia.
abstract: In children, clinical recognition of stroke and determination of its exact etiology are extremely difficult. The authors described a case of cryptogenic stroke in a 14-year-old-boy with asymptomatic atrial septal defect and hypercoagulable state. Paradoxical embolism was hypothesized as the responsible etiopathological mechanism. It is crucial to increase clinician awareness of stroke in children.
authors.affiliation: Department of Pediatrics, University of Florence, Anna Meyer Children's Hospital, Florence, Italy. g.indolfi@meyer.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Indolfi
authors.forename: Elisa
authors.initials: E
authors.lastname: Bartolini
authors.forename: Sandra
authors.initials: S
authors.lastname: Trapani
authors.forename: Chiara
authors.initials: C
authors.lastname: Azzari
authors.forename: Massimo
authors.initials: M
authors.lastname: Resti
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000925:Anticoagulants / Q000627:therapeutic use; D025861:Blood Coagulation Disorders, Inherited / Q000150:complications* / Q000235:genetics; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D005492:Folic Acid / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000235:genetics; D006423:Hemianopsia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000235:genetics; D020762:Infarction, Posterior Cerebral Artery / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D020766:Intracranial Embolism / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009778:Occipital Lobe / Q000098:blood supply / Q000473:pathology; D020521:Stroke / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D014805:Vitamin B 12 / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D005492:Folic Acid; D014805:Vitamin B 12