In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber.
The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug.
Kuyukina
M S
MS
Institute of Ecology and Genetics of Microorganisms, Ural Division of Russian Academy of Sciences, Perm. kuyukina@iegm.ru
Ivshina
I B
IB
Gein
S V
SV
Baeva
T A
TA
Chereshnev
V A
VA
D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology*; D053583:Interleukin-1beta / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D007962:Leukocytes / Q000166:cytology / Q000276:immunology; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D012240:Rhodococcus / Q000737:chemistry*; D013501:Surface-Active Agents / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D006017:Glycolipids; D007155:Immunologic Factors; D053583:Interleukin-1beta; D015850:Interleukin-6; D013501:Surface-Active Agents; D014409:Tumor Necrosis Factor-alpha