Rapid regulation of pancreatic alpha- and beta- cell signalling systems by estrogens.
Rapid estrogen actions are triggered after estrogens are bound to a variety of proteins in organelles other than the nucleus. Those include classic estrogen receptors ERalpha and ERbeta, novel membrane proteins that behave as estrogen receptors such as GPR30, ion channels, and other ligand receptors. In pancreatic alpha and beta-cells, estrogens binding to a non-classical membrane estrogen receptors at physiological concentrations regulate ion channels and [Ca(2+)](i) signals, provoking important physiological responses. In beta-cells, 17beta-estradiol regulates K(ATP) channel activity and glucose-induced [Ca(2+)](i) oscillations, eliciting changes in insulin release and the activation of Ca(2+)-dependent transcription factors. In alpha-cells, 17beta-estradiol abolishes low glucose-induced [Ca(2+)](i) oscillations.
Ripoll
Cristina
C
Instituto de Bioingeniería, Universidad Miguel Hernández de Elche y CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Elche 03202, Alicante, Spain.
Ropero
Ana B
AB
Alonso-Magdalena
Paloma
P
Quesada
Ivan
I
Fuentes
Esther
E
Nadal
Angel
A
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D006152:Cyclic GMP / Q000378:metabolism; D004958:Estradiol / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D050416:Glucagon-Secreting Cells / Q000502:physiology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology*; D054086:KATP Channels / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D015220:Calcium Channels; D004967:Estrogens; D054086:KATP Channels; D014157:Transcription Factors; D004958:Estradiol; D006152:Cyclic GMP