Power of the 2-locus TDT for testing the interaction of two susceptibility genes.
We recently proposed a new strategy: 2-locus TDT for detecting two susceptibility genes through their interaction in trio families. We apply our method to two candidate genes, A and C, on the Genetic Analysis Workshop 15 (GAW15) simulated rheumatoid arthritis data and study the power to identify an interactive effect of these genes.This study was performed with full knowledge of the answers.
Kotti
Salma
S
Université Paris-Sud, UMR-S535, 94817 Villejuif, France. kotti@vjf.inserm.fr
Bourgey
Mathieu
M
Clerget-Darpoux
Françoise
F