title: Gastric bypass: a risk factor for neural tube defects? Case report.
abstract: Gastric bypass surgery has become a safe and acceptable surgical weight loss treatment for individuals who suffer from morbid obesity. Patients who undergo this procedure are subject to vitamin deficiencies due to an iatrogenic malabsorptive state. Folate, a vitamin known for its role in the prevention of neural tube defects (NTDs), can be part of the deficiency spectrum resulting from this procedure. The authors describe the case of a woman who was nonadherent to multivitamin treatment after undergoing gastric bypass surgery. Her lack of understanding and appreciation of the relationship between gastric bypass surgery, folate deficiency, and NTDs may have contributed to her noncompliance with daily multivitamin consumption. As a result, her potential problems with folate absorption could have contributed to her subsequently giving birth to a child with a myelomeningocele. Thus, patient awareness and counseling along with aggressive vitamin supplementation among this particular population may help prevent the occurrence of NTDs after gastric bypass surgery.
authors.affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Moliterno
authors.forename: Michael L
authors.initials: ML
authors.lastname: DiLuna
authors.forename: Shreya
authors.initials: S
authors.lastname: Sood
authors.forename: Kurt E
authors.initials: KE
authors.lastname: Roberts
authors.forename: Charles C
authors.initials: CC
authors.lastname: Duncan
mesh_terms: D000328:Adult; D005260:Female; D005494:Folic Acid Deficiency / Q000209:etiology*; D015390:Gastric Bypass / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D008588:Meningocele / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D012307:Risk Factors