Foreign-body granulomas within intramyocardial arteries in a transcoronary safety assessment in pigs.
Foreign-body granulomas within intramyocardial arteries were detected in three domestic pigs (Sus scrofa domestica) in a routine transcoronary safety assessment study. The foreign bodies stained light grayish-blue by hematoxylin and eosin (H&E) and were strongly birefringent by polarized light microscopy. By their morphological features, they were identified as cotton fibers. Embolization of foreign-body material into the myocardial arteries following catheter-based procedures is an unusual event, and its occurrence may lead to granulomatous foreign-body reaction and misinterpretation of histological results.
Ramot
Yuval
Y
Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.
Amir
Gail
G
Willenz
Ehud P
EP
Nyska
Abraham
A
D000818:Animals; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000662:veterinary*; D003331:Coronary Vessels / Q000473:pathology*; D032561:Cotton Fiber; D004353:Drug Evaluation, Preclinical; D004617:Embolism / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007431:Intraoperative Complications / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology / Q000473:pathology*; D018675:Toxicity Tests