Zebrafish as a new animal model for movement disorders.
The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high throughput in vivo drug screening.
Flinn
Laura
L
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK.
Bretaud
Sandrine
S
Lo
Christine
C
Ingham
Phillip W
PW
Bandmann
Oliver
O
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006816:Huntington Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D009069:Movement Disorders / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D015027:Zebrafish / Q000235:genetics* / Q000378:metabolism
D000978:Antiparkinson Agents