Cytotoxic sesquiterpenoids from Vernonia bockiana.
Two new sesquiterpenoids, vernobockolides A (1) and B (2), along with five known ones, piptocarphin C (3), piptocarphin F (4), piptocarphin A (5), hirsutolide (6), and beta-d-glucopyranosyl taraxinic ester (7), were isolated from the aerial part of Vernonia bockiana. Their structures were determined by spectroscopic analysis, especially 2D NMR. Among them, compounds 2-6 showed strong cytotoxic activities against mouse lymphoid tumor cell line P388 with the IC(50) values of 1.81, 1.32, 0.77, and 0.73 microM, respectively.
Huo
Jun
J
Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Yang
Sheng-Ping
SP
Xie
Bo-Jun
BJ
Liao
Shang-Gao
SG
Lin
Li-Ping
LP
Ding
Jian
J
Yue
Jian-Min
JM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D035741:Vernonia / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes