title: [Experimental basis for possible tumors induction in descendants after placental transmission of chrysotile asbestos fibers].
abstract: Experiments on white outbred rats helped to establish placental transmission of chrysotile asbestos fibers from mother to fetus with reliable increased incidence of neoplasma in first generation, mainly of respiratory malignancies. Chronic exposure to chrysotile asbestos damaged peripheral lymphocytes and did not affect red bone marrow. Extrapolating the experimental data on placental transmission of chrysotile asbestos to children requires epidemiologic research.
authors.forename: N N
authors.initials: NN
authors.lastname: Vanchugova
authors.forename: S V
authors.initials: SV
authors.lastname: Kashanskiĭ
authors.forename: E S
authors.initials: ES
authors.lastname: Tregubov
authors.forename: L A
authors.initials: LA
authors.lastname: Skriabin
mesh_terms: D000818:Animals; D017632:Asbestos, Serpentine / Q000493:pharmacokinetics* / Q000633:toxicity; D001195:Asbestosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects; D009374:Neoplasms, Experimental; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
chemical_list: D017632:Asbestos, Serpentine