Two new triterpenes from the Rhizome of Dryopteris crassirhizoma, and inhibitory activities of its constituents on human immunodeficiency virus-1 protease.
Two new hopane type triterpenes, named dryopteric acids A (1) and B (2), were isolated from the Rhizome of Dryopteris crassirhizoma (Aspiadaceae) together with sixteen known compounds (3-18). Of isolated compounds, ursolic acid (15), and dryopteric acid A (1) and B (2) showed potent inhibitory activities against HIV-1 protease with IC50 values of 8.9-44.5 microM. In addition, acetylated compounds 1 and 2 appreciably increased inhibitory activities with their IC50 values of 1.7 and 10.8 microM, respectively.
Lee
Ji Suk
JS
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak-Gu, Seoul, Korea. jslee103@snu.ac.kr
Miyashiro
Hirotsugu
H
Nakamura
Norio
N
Hattori
Masao
M
D032492:Dryopteris / Q000737:chemistry*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D018517:Plant Roots / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D017320:HIV Protease Inhibitors; D007202:Indicators and Reagents; D014315:Triterpenes; C529723:dryopteric acid A; C529724:dryopteric acid B