title: Beyond the implantable cardioverter-defibrillator: are we making progress?
abstract: Sudden cardiac death due to ventricular fibrillation occurs when a dynamic interaction between triggers and substrate leads to the development of reentry, initiation of ventricular tachycardia, and its degeneration to fibrillation. To move beyond the implantable cardioverter-defibrillator as the only effective therapy for aborting sudden cardiac death, an improved understanding of trigger-substrate interaction is essential. This brief review summarizes some of the recent progress in this direction.
authors.affiliation: UCLA Cardiovascular Research Laboratory, Department of Medicine (Cardiology), David Geffen School of Medicine at UCLA, Los Angeles, California, USA. jweiss@mednet.ucla.edu
authors.forename: James N
authors.initials: JN
authors.lastname: Weiss
mesh_terms: D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000295:instrumentation / Q000639:trends*; D004867:Equipment Design; D006801:Humans; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000150:complications / Q000503:physiopathology / Q000628:therapy*