Kinetic resolution of racemic pyrrolidine-2,5-diones using chiral oxazaborolidine catalysts.
Kinetic resolution of racemic C-3 substituted pyrrolidine-2,5-diones has been achieved for the first time using highly efficient oxazaborolidine catalysts derived from cis-1-amino-indan-2-ol.
Barker
Mike D
MD
GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK SG1 2NY.
Dixon
Rachel A
RA
Jones
Simon
S
Marsh
Barrie J
BJ
D001372:Aza Compounds / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D007189:Indans / Q000737:chemistry; D007700:Kinetics; D013237:Stereoisomerism; D013388:Succinimides / Q000737:chemistry* / Q000302:isolation & purification
D001372:Aza Compounds; D001896:Boron Compounds; D007189:Indans; D013388:Succinimides; C116915:aminoindanol