Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe.
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).
Kim
Ju Sin
JS
College of Pharmacy, Woosuk University, Samrye, Korea.
Lee
Sa Im
SI
Park
Hye Won
HW
Yang
Jae Heon
JH
Shin
Tae-Yong
TY
Kim
Youn-Chul
YC
Baek
Nam-In
NI
Kim
Sung-Hoon
SH
Choi
Sang Un
SU
Kwon
Byoung-Mog
BM
Leem
Kang-Hyun
KH
Jung
Mun Yhung
MY
Kim
Dae Keun
DK
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003890:Desiccation; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020939:Zingiber officinale / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D027343:Rhizome
D000972:Antineoplastic Agents, Phytogenic; D002396:Catechols; D005233:Fatty Alcohols; C040115:shogaol; C007845:gingerol