title: A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs.
abstract: In this report, we present results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Study on the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.
authors.affiliation: Human Genetics Unit, Indian Statistical Institute, Kolkata, India. saurabh@isical.ac.in
authors.forename: Saurabh
authors.initials: S
authors.lastname: Ghosh
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Bierut
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Danielle
authors.initials: D
authors.lastname: Dick
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: John
authors.initials: J
authors.lastname: Kramer
authors.forename: John
authors.initials: J
authors.lastname: Rice
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D002648:Child; D002878:Chromosomes, Human, Pair 1; D002884:Chromosomes, Human, Pair 15; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D012044:Regression Analysis; D035781:Siblings
chemical_list: D000426:Alcohol Dehydrogenase