Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes.
We compared results from linkage analyses of different phenotype measurements from the same gene expression traits and found that the strongest signals were detected by all expression measures that we considered. On average, that meant that the same quantitative trait loci (QTLs) were detected across methods, but the magnitude of the LOD score of each particular QTL and the false-positive ratio of QTL detection varied between the methods.
Peralta
Juan Manuel
JM
Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, 2060, San José, Costa Rica. jperalta@sfbrgenetics.org
Almasy
Laura
L