title: Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.
abstract: Streptomyces clavuligerus produces a large array of natural compounds with antibiotic, antitumor, beta-lactamase inhibition or inmunomodulating activities. The production of cephamycin C, clavulanic acid and other compounds with a clavam structure has been studied for many years. A network of regulatory mechanisms is present in S. clavuligerus to control the formation of different compounds by pathway-specific regulators or pleiotropic regulators. The possible existence of a gamma-butyrolactone signaling system in this streptomycete is emerging. In addition, S. clavuligerus possesses a stringent control mechanism somehow different from those previously reported in other Streptomyces species.
authors.affiliation: Instituto de Biotecnología de León, INBIOTEC, Parque Científico de León, Av. Real, 1, 24006 León, Spain. paloma.liras@unileon.es
authors.forename: Paloma
authors.initials: P
authors.lastname: Liras
authors.forename: Juan P
authors.initials: JP
authors.lastname: Gomez-Escribano
authors.forename: Irene
authors.initials: I
authors.lastname: Santamarta
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D015964:Gene Expression Regulation, Bacterial; D053858:Metabolic Networks and Pathways; D013302:Streptomyces / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents